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<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W6PQ09</accession>
    <name>W6PQ09_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">chitinase</fullName>
            <ecNumber evidence="3">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PROQFM164_S01g000062</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 18 family. Chitinase class V subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="3"/>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PQ09"/>
    <dbReference type="STRING" id="1365484.W6PQ09"/>
    <dbReference type="OMA" id="AGPANYH"/>
    <dbReference type="OrthoDB" id="76388at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06548">
        <property type="entry name" value="GH18_chitinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.10:FF:000005">
        <property type="entry name" value="Endochitinase B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF317">
        <property type="entry name" value="CHITINASE 12-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="Chitinase insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="7 9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 9 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004881509" description="chitinase" evidence="10">
        <location>
            <begin position="18"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="11">
        <location>
            <begin position="39"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDM26253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="377" mass="41864" checksum="BC39F18F13263389" modified="2014-04-16" version="1">MHFVVLFLVCLARLANTAYSLLSTKIDSTDIATRDSNGYRSVAYFVNWGIYARDFHPQDIPAERLTHVLYAFANAQDSGEVIMSDDWSDTDKHYSTDSWTDSGSNVYGCVKQLFLLKKKNRNLKVLLSIGGWTYSSNLKKSFETEEGRQNFANSSIELLKNLGFDGIDVDFEALDLYSSTNNDGYHFLLTAASPAGPANYHKEHLARMDQYLDFWNLMAYDYAGSWDTVAGHNANLHPSNDNPGSTPFNTDQAINYYISHGVASHKIVMGMPLYGRAFSDTNGPGQAYNGVGAGSWENGVWDYKALPQPCCAVTNLDEAAASYCYNSKSRLFISYDTTEIARKKGEYIKSNGLGGGMWWELSGDKQGDDSLIATCAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W6PR26</accession>
    <name>W6PR26_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ankyrin repeat-containing domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PROQFM164_S01g000005</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ankyrin SOCS box (ASB) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PR26"/>
    <dbReference type="STRING" id="1365484.W6PR26"/>
    <dbReference type="OMA" id="DVNKCDR"/>
    <dbReference type="OrthoDB" id="4772757at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045732">
        <property type="term" value="P:positive regulation of protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051573">
        <property type="entry name" value="Ankyrin-SOCS_box_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24136:SF15">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24136">
        <property type="entry name" value="SOWAH (DROSOPHILA) HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="85"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="186"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="220"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="296"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="329"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDM26196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="413" mass="44523" checksum="512947B91BFDEBB2" modified="2014-04-16" version="1">MCLLSLPPELILLVAGNLDSPKDFLGFLLTSPKCYNLLINELYQKNVRSDGGSALLWYASRGAELGVRNMLRAGANVNLRSPNRAQLTALLEAVKHKHTSVVQILLESGALPDAADARSRRPLALATNGRSDVAITKLLLENGARADSAVFDKHAPLFEAVRSSQESKVALLLKHGADTYVLDCRTGMNLVYIAASKNATSGIINILIDSGIQIESQDDMGRTPLQVAAENSCTRAVRLLLHLGANPNFKNMNQYREGLSALFYAATNPNSPGNGNKSIIRALFIHGAEIDTENHAYKTPLLYAISQSAIKQAQALVECGANIMARDSNGETVLHLAASLSSCSPSLMDWLVENGADANWAGGQQETWEAAGELLKAGADRCAISNDGKFPHDMVPDGPWAETKRSLIRFYMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2024-10-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>W6PSK8</accession>
    <name>W6PSK8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S01g001012</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PSK8"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM27203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="37" mass="4099" checksum="BF2947A5C0A30EA5" modified="2014-04-16" version="1">MSFWSGLSRQFIYAAIPKSLGLDTAQGQHEKLFKGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W6PU51</accession>
    <name>W6PU51_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g001211</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PU51"/>
    <dbReference type="STRING" id="1365484.W6PU51"/>
    <dbReference type="OMA" id="AMQWEEC"/>
    <dbReference type="OrthoDB" id="417697at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF96">
        <property type="entry name" value="PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase" evidence="1">
        <location>
            <begin position="51"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM27400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="281" mass="31720" checksum="B4F7C68B649FF376" modified="2014-04-16" version="1">MSLFMDPYAENMQRDSTEAQRLDEQFALLTENIGYLLHPSVRDKMHPHARVADIATGTAAFLRYLAHDWPDAILHGFDISTSLYPPVRTLPNNVTLHVLDARKDVPVNLYGQYDIVHIRLIAAGLTASEWGRTVRNLAKLLKPGGAMQWEECDFTNVRHFPGSATSTTDAASAMGFTFMTAMRPRFKHGWNRLATEMRNAGLVEVHTEAVSADRVYDTRTRLTANGMRAMFAWARLHSARGSPGALHMWQIDELEQRAYADIQSGCYVTFDIHVAWGFRPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>W6PVC4</accession>
    <name>W6PVC4_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Proteasome subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">PUP3</name>
        <name evidence="6" type="ORF">PROQFM164_S01g001636</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the proteasome complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the peptidase T1B family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PVC4"/>
    <dbReference type="STRING" id="1365484.W6PVC4"/>
    <dbReference type="OMA" id="CSEQLYG"/>
    <dbReference type="OrthoDB" id="204949at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03759">
        <property type="entry name" value="proteasome_beta_type_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000003">
        <property type="entry name" value="Proteasome subunit beta type-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033811">
        <property type="entry name" value="Proteasome_beta_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF10">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA TYPE-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 5 6" id="KW-0647">Proteasome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00026071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDM27825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="206" mass="22534" checksum="CF40A2827D8278AF" modified="2014-04-16" version="1">MSNPFDINGGACVAMVGKDCVAIACDLRLGMQSLTISNNFPKIFNYAPSTYLGLTGLATDVNTVSDLFRYKVNMYRLREERDIAPQTLANLVSSSLYEKRFGPYFVSPVLAGINPTTGKPFICGFDSIGCIDFAKDFIVSGTASDQLFGTCEGLWEPDLAPEDLFETISQALLSAVDRDALSGWGAQVYIIEKDKVTQRLLKGRQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W6PVV4</accession>
    <name>W6PVV4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="5">F-box domain, cyclin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PROQFM164_S01g001722</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PVV4"/>
    <dbReference type="STRING" id="1365484.W6PVV4"/>
    <dbReference type="OMA" id="WRRLEWF"/>
    <dbReference type="OrthoDB" id="366390at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="F-box" evidence="4">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="190"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="333"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDM27911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="418" mass="47108" checksum="F04D6C8E2180B939" modified="2014-04-16" version="1">MTTLSELPNEMLLEISLHLDYRDLNAFTRVSRHFHALSNRNLYKAIAKDSPGKSIAWAAEKGKEASARKLLQMCGSKILDDLPIFEGQEPIRIAAWKGHTNIVELFLPYCIQHDTEKEGDLFNRTLKAAVTSEHAAVVKLLLEHKADCKTNSHDRHAAIPLCKAVELGHVSIVRLFLEYNYCSLDTYDLRGMTPLAVAAATRPSPANLEIAQLLVGAGADLYIYDKLLLEAAGSDNLPVMKLLLANNLHWRQLGWLEVLWEFSRPRDNHEMGSLLLSWIDVDRILKYGNLQRCYLLKGAIVNRLDDLLEKVLKESSVLDKDHQPNRRAVHFCPLSLAVCYGRPRAVKLLLDHGADPSGEGNSRPVQLALEKGKDTMARLLFDKGATFDPDMCFGSSEYRQLLKLRMARVQRRPVSQEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>W6PWM8</accession>
    <name>W6PWM8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Probable transposable element</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PROQFM164_S01g000163</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001525">
        <property type="entry name" value="C5_MeTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
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        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
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        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF26">
        <property type="entry name" value="FAMILY HELICASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G09120)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
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    </dbReference>
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        <property type="entry name" value="HELICASE_CTER"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ZF_RING_2"/>
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    </dbReference>
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    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
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    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="11">
        <location>
            <begin position="1816"/>
            <end position="1854"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="12">
        <location>
            <begin position="1886"/>
            <end position="2053"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1342"/>
            <end position="1414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1346"/>
            <end position="1361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDM26354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="2065" mass="232704" checksum="E7A9E075CEA15C26" modified="2014-04-16" version="1">MVSKGISQQQSGDGLAMDDQESSAGADEIPELRRGRMIPSGRYLANNLPPLHTLREIFADMASKAMEIGLEQVLIRLGSRPLRVATMCSGTEAPLLALELIQKGLPEAQQLRILHAFSCEIVPFKQSYIERNFRPPLLFRDITELGGDEARTAYGSLEAIPGNLDILVAGTACVDFSPLNNRQKTLQQGGESGATFDGLLRYAKRYRPRMIVQENVRNAPWEQMKGKWEELRYMSVCVNVDTKHYYIPQTRERGYMVVIDKHRLEAAGLLGDTMDQSGIEIVTQRVRELADRFKRPASAPVGLFLLSDDDRRLELIEMRARLESRSETSWDQYQIRHQRHRDELELGSERPITRSLPGINELKTPDFYWHRFWKTQSERVWETVDMNFLKKMLQDYDMNFKERWIDLSQGVDRGNDSLAGSGIAGCLTPKGMPFVTTRGGPVSGTEALSLQGLPLDRMLLTRETQADLMDMAGNAMTSTVVCAIMLAGLIAVHEILDDGEEFSTNSGEAEAKSLLVPSEAHSLVRSNLQVVQTPLIDHAVLKVKAASSVLCCSCERQTRVQDSIYSCTLCGHTACKSCRGNPTHSYLHVSPLSRQKPSEFIANLKALVPMKLMLSDLSDLGFEMFRSLYHITNLPRFWPDFIMCVKAAVHDVFRFFEIKRGRKWRVVYDGTHSSLYLDIGPDSFQWLLYAKPPKSASRRSVIREVLAKPIARMSPTSGSLVEGTWEISSPISTPILLQISGRGHQVRSFQSECGIKAAKFVDGKVWDSIFVEGSDQNVAALDFDVRGMYQFLPDCGTALGALYRRKATAHAPRIFLFLDPAKIGPADEDAFVFALEHDRLPGYDVRMTIAELSSKWTSLNVTMDSQDVKAFCRRWAKAPKAHLNQCPAEQITLHTLQQGMQVSIENQNCHDACITLTSLSATTSILNLPDANSDWQAWNPEVSMRELKGLAWLFPKIAAWSDFKDWNEIILPDCSDLKHHANGNCNTCNPPTPSILWGRDNRDRIIPYENPQDAAVYERAIKNRPSPFLVFRRINEHGDAELRFTLNVQALTHQAHGKLFGTASHEGVTSFWRLLPHAYDMSQETPGIFTLRSNDNDSLSPQPPNFKFKLRDEQLRSLSWMITQEAKEMEPFMEEEVEESILPLMPWRAEVKATMPKVVRGGVLADEVGYGKTAVILGLIDTQYESDCKPPEENGLISTKATLIIVPSNVFKQWVSETKKFLGGKYKVLAISSISKITIREVEDADIVILSWSILANDAYYSRLQQFTGTPQAPAKSSGGTGRNFDSWFHNARASLRESVDILKTQGSEAMLRQLEARRRRVQETQANFTYVPSRRLRGQAFADAKNGRDECNAGEERNLDSESDSGFEDFGASDARQSPEAGQRKRRHSRKSVEGPRGKRQKHSLTELTEVTDDGKKLGAKSTAVKDDRKDFDINKTAEHDWRTVKAAFIHAFNFNRLVIDEYTYAGDERQASLLSLQARSKWILSGTPALREFADIKSVARYLGLHLGVDDDGDCDKPTQNSRLRNIRKNHTAVEAFQYYQAPHSNAWYQNRREHAQNFLDRFARQNIARITHIPLKTTFVVTEQSPAEKTAYDTLLRAVKENKRRIPGPLSTILSKSQVPQEALIMSCVTNQIGQPPWNLEKCRKGSQNDKKKSAEIWTKVDSITRQAAIVWYRELKNTDPNNWQKALNGVAKIDFGDAQLNKRFKQLLEDIIRSYSEWKLAEQHQPIDDLLQQRFQKIQNSKTGNKATGKRPPRATEYGKPVDAFSNSVWIAVEKTLSADVTSLLKQVLEIDREYRFYEHLVRIQTIGILPCQKCNGDLQEKEDVNVLKTCGHVLCKDCIAAGSRKPCPIIGCGGQIVQSKIVPGEILVSEDQEIQSTKLNKLVEIVRNVPEEELVLIFVQINHLLPVVSNALKAANIDHRMVTQTNLKGIDEFTEAPKLKKGMTQPPSRPKALILNLGNSMAAGLNLQCANHVIFLSPYFAPSDHDFEAGMTQAVGRARRFGQEREVHVYHLLVKNTYEVNIFQKAQSSKLVERQGVHVLVPEEEVLPNDIGCEGEEMPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W6PX36</accession>
    <name>W6PX36_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S01g002584</name>
    </gene>
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        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM28773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="127" mass="14298" checksum="949A6149ABCA5DA6" modified="2014-04-16" version="1">MNVSEQEESYHKVACFPELIFMSLCAAASQTSENTASVYEAMRLYKKTNPREKHSKKLIRGAIWANRSIFALAETTWGPECSNAFLFGKYNISDLAFMQELIASSRRICLLLCPIRGACQKAARGEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2024-10-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>W6PX96</accession>
    <name>W6PX96_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S01g002217</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PX96"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM28406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="66" mass="7298" checksum="5BD18D41D74C3D92" modified="2014-04-16" version="1">MEYLHRPEAMVTSIIHGSGPDCITTADSRSAQTLASRESGLGRVQHWGVPCVRDRGNFRMPISDSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>W6PXJ3</accession>
    <name>W6PXJ3_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 11">Mitogen-activated protein kinase</fullName>
            <ecNumber evidence="2 11">2.7.11.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PROQFM164_S01g000488</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="11">Activated by threonine and tyrosine phosphorylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8 11">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.24" evidence="2 11"/>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PXJ3"/>
    <dbReference type="STRING" id="1365484.W6PXJ3"/>
    <dbReference type="OMA" id="GKNHINQ"/>
    <dbReference type="OrthoDB" id="192887at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004707">
        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000049">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003527">
        <property type="entry name" value="MAP_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01351">
        <property type="entry name" value="MAPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 11 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="34"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00061056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDM26679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="379" mass="42858" checksum="4DCC39B95E2486DE" modified="2014-04-16" version="1">MMPTGLPTPPYGERMATFSQKSVMGTLFETTERYTEWKPLGLGVSGLVCSARDQLAHRTVAVKKLSEPFKTPAIARHMFREMKLLRQLRHENIINLTDIFISPSEDIYIVTELMATDLDTILKAKRVEDQFAQYFMYQIMRGLKYLHSAGVIHRDLKPSNILVNENCDLKICDFGLARIQESHMTGYVSTRYYRAPEIMLTWRKYNEKVDIWSAGCIFAELLLGEPLFPGKNHINQFCVITDLLGSPPEEVINNITSENTLNFINSLPKRARTPISQLIPKANVNAAELIDQMLQLDPQVRISAAEALSSPYLAPYHDPNDEPVAAETFDWAFLEAELPADIWKTIIYGEVLGFHAEMNQTGQSGPMKSINQVDGMDIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W6PXM1</accession>
    <name>W6PXM1_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AAA+ ATPase domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S01g000513</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PXM1"/>
    <dbReference type="STRING" id="1365484.W6PXM1"/>
    <dbReference type="OMA" id="DRHIYVA"/>
    <dbReference type="OrthoDB" id="27435at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19511">
        <property type="entry name" value="RecA-like_CDC48_r2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001721">
        <property type="entry name" value="AAA family ATPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF27">
        <property type="entry name" value="ATPASE FAMILY GENE 2 PROTEIN HOMOLOG A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="3">
        <location>
            <begin position="240"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="3">
        <location>
            <begin position="523"/>
            <end position="657"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM26704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="751" mass="83735" checksum="9449CBE3B664BEFB" modified="2014-04-16" version="1">MSDARSFTARPLSKQQARKDFKDAFRVYLSSSSLAALRLQTESICTLRQADGPPQTAIAWYASENIQSTVMQISRTLQDCYDIKIGEKVSITRAEGSLENIDLVTLADCSDPEKIAKHGSISESDRSHWEWALDEKLLRCGCLTTGLTFELELKGQPRSFRVVNIHSQNPHSRHTLFQFTEASKVSLGPVIERKEEKSSDIAVQSTGLGGLSRQIDDINECLSDFNIDLRKPAMPSFYENSRGILLYGPKGTGKTSLLEQIEKAGWKQTFKIGMSTLGRSVNEGEVKLRNIFQEAARSNPSVIIIDQLEFIAPKRTSVESQSLASVLCENLDAIRNKSILVVAATRNPNQVDDALRTPHRLGTEIEIQVPTAQDRAEILHAIRGPVSAGLTDELVEILAEKTHGYVGADLFALLQLVCRKARQRQLLDKSSTAISTSPIDQYSSLHGGSSDDELAISLEIQETDILLSLQEIRPTAMREVFLETPKVRWSDIGGQHDIKKRLQQAVERPLKYPQRMRRLNVNSKKGVLLYGPPGCSKTLTVKALATEAGLNFLAVKGAEILSMYVGESERSLREIFRKARAARPSIIFFDEIDAIAARRSSTSGGVNVLTTLLNEMDGIEELRNVLVIAATNKPDVLDPALMRPGRLDNILYIGPPDFEARREILRIWTKKSVVNPDVDLDNLASLTEGYSGAEIVSICETAGDAALDEEEETQQEQDVQWKHFQYALGQVRRQITDTVIQEYERWREGYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W6PXT3</accession>
    <name>W6PXT3_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DJ-1 domain, InhA-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S01g000573</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PXT3"/>
    <dbReference type="STRING" id="1365484.W6PXT3"/>
    <dbReference type="OMA" id="LRPLHYH"/>
    <dbReference type="OrthoDB" id="543156at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052158">
        <property type="entry name" value="INH-QAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43130">
        <property type="entry name" value="ARAC-FAMILY TRANSCRIPTIONAL REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43130:SF15">
        <property type="entry name" value="THIJ_PFPI FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G14240)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM26764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="274" mass="30201" checksum="1AE0DE7B2696EF22" modified="2014-04-16" version="1">MALRPLHYHLPLFPGFQLLDVAAPLDILNIRTQYPDTSAITLTISAETLDPVSVKPIPPPKAKWRFDLPVSNINTACNQQMLPQCTFADVISALKAGKVADDGSGEFKPIDVLIIPGGPGTRLDRIYDTDTTFNEAKVSNTQEVRDFLTAVAPYVRHSIITVCTGSHVLSQTRLLDGLQVTTNSARYDDIAKQTGGVNWQRNKRWLRDSVSKDAVSDGLLLPGIEIWSSAGITAGIDVMLEFISAHYGGIAVGVETAKRMEYRWEREKEASYFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>W6PY63</accession>
    <name>W6PY63_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Replication protein A subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">ssb1</name>
        <name evidence="14" type="ORF">PROQFM164_S01g003015</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">As part of the replication protein A (RPA/RP-A), a single-stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the heterotrimeric canonical replication protein A complex (RPA).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the replication factor A protein 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PY63"/>
    <dbReference type="STRING" id="1365484.W6PY63"/>
    <dbReference type="OMA" id="DQCDAFY"/>
    <dbReference type="OrthoDB" id="1751331at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005662">
        <property type="term" value="C:DNA replication factor A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007004">
        <property type="term" value="P:telomere maintenance via telomerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04474">
        <property type="entry name" value="RPA1_DBD_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04475">
        <property type="entry name" value="RPA1_DBD_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04476">
        <property type="entry name" value="RPA1_DBD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04477">
        <property type="entry name" value="RPA1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000041">
        <property type="entry name" value="Replication protein A subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000064">
        <property type="entry name" value="Replication protein A subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000090">
        <property type="entry name" value="Replication protein A subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000117">
        <property type="entry name" value="Replication protein A subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047192">
        <property type="entry name" value="Euk_RPA1_DBD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013955">
        <property type="entry name" value="Rep_factor-A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007199">
        <property type="entry name" value="Rep_factor-A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031657">
        <property type="entry name" value="REPA_OB_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004591">
        <property type="entry name" value="Rfa1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00617">
        <property type="entry name" value="rpa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47165">
        <property type="entry name" value="OS03G0429900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47165:SF4">
        <property type="entry name" value="OS03G0429900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04057">
        <property type="entry name" value="Rep-A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08646">
        <property type="entry name" value="Rep_fac-A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16900">
        <property type="entry name" value="REPA_OB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Replication factor-A protein 1 N-terminal" evidence="11">
        <location>
            <begin position="10"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="OB" evidence="10">
        <location>
            <begin position="187"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="Replication protein A OB" evidence="13">
        <location>
            <begin position="297"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="Replication factor A C-terminal" evidence="12">
        <location>
            <begin position="451"/>
            <end position="597"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF16900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDM29203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="607" mass="67553" checksum="B072535C1B545427" modified="2014-04-16" version="1">MASEAASQITIGALSAIFDETKPQVPEPIVQCVQIKTLPSPPNQPERYRAVFSDIANYVQTMIATQEATGVVKDGSLRKGCFVRLTSFQSNVVKGKNILVILGLEVLTELGEAEKIGDPKPLAVKSEEEEVGQPTTISSNGFYGSKMEGAQAQPNSRAQPISAPMSTSSVHATIYPIEAVSPYSNKWTIKARCTNKSAIKTWHNKNGEGRLFSVNLLDDSGEIRATGFKEQCDMLYELFQEGSVYYISTPCKVQIAKKQFSNLNNDYELVFERDTIVEKAEEQNDIPQIRYNFTTVADLQTVEKDTTTDVIGVLTEIGEASQIVSKSTGKPYEKRELTLVDNTGFSVRLTIWGATAQNFSVTPESVVAFKGVKVSDYGGRSLSLLSSGSMTVDPDIGEAHRLRGWYDAQGRSETFTSHVSNATNSMGKRDPFKTIAQVREEQLGMSETFDYFSLKATVIFIKQDNVWCYPACLSDNCNKKVTELDPGQWRCEKCDKTYPKPEYRYVLPISVGDHTGQLWLSCFDDTGRKIMGTSADDLMQLREDDSNAFGEVFQTANCQTWNFRCRAKTDNFGDQQRVRYQVSSCQPINYSEEASRLADIIDSYSIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>W6PYS8</accession>
    <name>W6PYS8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Arf GTPase activating protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PROQFM164_S01g003235</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PYS8"/>
    <dbReference type="STRING" id="1365484.W6PYS8"/>
    <dbReference type="OMA" id="MSKLWEV"/>
    <dbReference type="OrthoDB" id="983479at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032012">
        <property type="term" value="P:regulation of ARF protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030100">
        <property type="term" value="P:regulation of endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08830">
        <property type="entry name" value="ArfGap_ArfGap1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.150:FF:000014">
        <property type="entry name" value="ADP-ribosylation factor GTPase-activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46395">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46395:SF1">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Arf-GAP" evidence="7">
        <location>
            <begin position="10"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="133"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="206"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="336"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="133"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="144"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="172"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="242"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="337"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="399"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM29423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="437" mass="46590" checksum="47A6472AFD57B6F6" modified="2014-04-16" version="1">MSRMWEVDPETRTKLLQISKTNGNDKCCDCGAPSPQWASPKFGTFICLNCAGTHRGLGVHISFVRSITMDAFKHSEIQRMELGGNEPWKSFYDEHPVTVSEGRTFEDSTIKERYDSDEGEEWKERLSCKADGREYVQGQEKKNNAPSRSNTTSKLTGTTVAGAGAVAGGRAGSPAASSIRSGDSLRGVPGKKEQNEAYFAKLGNENATRVDSLPPSQGGKFTGFGGGMPAPAASDRRTSPFGGFGGWGVGGGGGGGGGQPFEDLQKDPLGTITKGLGWFTSTVGKSAKQVNDAYLQPTAKQLAESEFAAQARLHAATLGQGLQTGVRGAADQFNKFVEGEDGRGDGRRNRVEPERRDFWDDFASMGDQETPSHRRSASQRSQRSQRSDVVGTAAMRKSPTASSLGHSTPGLSGEAGEGKNTTASATGKGKDEWDDNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q0M9</accession>
    <name>W6Q0M9_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein arginine methyltransferase NDUFAF7</fullName>
            <ecNumber evidence="7">2.1.1.320</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PROQFM164_S01g001555</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Arginine methyltransferase involved in the assembly or stability of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>L-arginyl-[protein] + 2 S-adenosyl-L-methionine = N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:48108"/>
            <dbReference type="Rhea" id="RHEA-COMP:10532"/>
            <dbReference type="Rhea" id="RHEA-COMP:11992"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29965"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:88221"/>
            <dbReference type="EC" id="2.1.1.320"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the NDUFAF7 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.320" evidence="7"/>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q0M9"/>
    <dbReference type="STRING" id="1365484.W6Q0M9"/>
    <dbReference type="OMA" id="YYHPQRN"/>
    <dbReference type="OrthoDB" id="5595109at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035243">
        <property type="term" value="F:protein-arginine omega-N symmetric methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003788">
        <property type="entry name" value="NDUFAF7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038375">
        <property type="entry name" value="NDUFAF7_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12049">
        <property type="entry name" value="PROTEIN ARGININE METHYLTRANSFERASE NDUFAF7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12049:SF7">
        <property type="entry name" value="PROTEIN ARGININE METHYLTRANSFERASE NDUFAF7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02636">
        <property type="entry name" value="Methyltransf_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 9" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="346"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="346"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM27744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="507" mass="55694" checksum="1C67BC4BB8F97A49" modified="2014-04-16" version="1">MNQTTRRVASYVLRRPRNPVLLRCPGRWNSTFEQREWSTPLAKTLASVMRVTGPVPIAAFMRQVLTSPDGGYYTTRGEGGGVFGKNGDFVTSPEISQVFGELIGIWTIAEWMAQGRTKSGVQLMEVGPGKGTLMDDMLRTFRNFKSFSSSVEAIYLVEASGTLREVQKRLLCGEKAVMEETDIGHRSVCKYFDVPIVWVEDIRLLPHEEGKTPFIFAHEFFDALPIHAFESVPPSPENQIANEPRKIMTPTGPVELHNPPKHANTPQWRELMVTLNPKAVEENIKGEPEFQLTKAKASTPSSLVIPEISQRYRALKSQPGATIEISPESRIYAADFARRIGGDSASALAAKKTSPSSPPPSSQKKTPSGAALIMDYGTLSTIPINSLRGIKSHKKVPPLSEPGRVDVSADVDFTSLAEAAIEGSDGVEVHGPVEQGDFLAAMGIEERMQQLLRKVQDEEHKKTLETAWKRLVEKSGGSMGQIYKVMAIIPENGGQRRPVGFGGGIQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q132</accession>
    <name>W6Q132_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Exportin-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">xpo1</name>
        <name evidence="9" type="ORF">PROQFM164_S02g000169</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">tRNA nucleus export receptor which facilitates tRNA translocation across the nuclear pore complex. Involved in pre-tRNA splicing, probably by affecting the interaction of pre-tRNA with splicing endonuclease.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the exportin family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q132"/>
    <dbReference type="STRING" id="1365484.W6Q132"/>
    <dbReference type="OMA" id="WAFKHNN"/>
    <dbReference type="OrthoDB" id="27218at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005049">
        <property type="term" value="F:nuclear export signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006611">
        <property type="term" value="P:protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000056">
        <property type="term" value="P:ribosomal small subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000490">
        <property type="entry name" value="CRM1p Major karyopherin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041123">
        <property type="entry name" value="CRM1_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041235">
        <property type="entry name" value="Exp1_repeat_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013598">
        <property type="entry name" value="Exportin-1/Importin-b-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045065">
        <property type="entry name" value="XPO1/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014877">
        <property type="entry name" value="XPO1_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040485">
        <property type="entry name" value="XPO1_repeat_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11223">
        <property type="entry name" value="EXPORTIN 1/5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11223:SF2">
        <property type="entry name" value="EXPORTIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08767">
        <property type="entry name" value="CRM1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18777">
        <property type="entry name" value="CRM1_repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18784">
        <property type="entry name" value="CRM1_repeat_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18787">
        <property type="entry name" value="CRM1_repeat_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08389">
        <property type="entry name" value="Xpo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01102">
        <property type="entry name" value="CRM1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="8">
        <location>
            <begin position="26"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM30020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="1072" mass="122749" checksum="CE94C345D25389FE" modified="2014-04-16" version="1">MSISVQELDNTVRALFEGKGAVQNQAQQTLTEFKQNPDAWVTVGNILQEASYLQTKYIALQVLDNVIMTRWKVLPRDQCQGIRNFIVRFILENSESEEKIQAERPLLNKLNLVLVSILKQEWPHNWPTFINEIISSCHASLSICENNMTILRLLSEEVFDFSQDQMTSAKARNLKTSMTSEFASIFQLCSEVLSTANQPSLVKATLETLLRFLNWIPLGYIFETPIINTLLTRFLGEPEFRNVTLKCLTEIGGLQIGAPYNYDERLVHMFTETLTTVSNVIPLSLDLKQTYAMSNGRDQEFVSNLALFLSSFFSAHLDLIEKLPNQDYLTHAHFYLIRVSQIDDREVFKICLDYWTRLVQELYEEMQQLPITDINPLVSMSVSGLANGGAPNPTTLANYPLRKHKYETVLTNLRTVMIEKMVRPEEVLVVENDEGEIVREFVKESDTIQLYKTIRECLVYLTHLDVVDTETIMVDKLAKQVDGTEWSWVNCNTLCWAIGSISGAMNEETEKRFLVTVIKDLLGLTEQKRGKDNKAVVASNIMYIVGQYPRFLKAHWKFLKTVVNKLFEFMHETHEGVQDMACDTFIKIANKCRRHFVALQPGESEPFIEEIVRNMRKITMDLSPQQIHTFYEACGYMISAQGQKGLQDRLTENLMALPNTAWDQIIAEANQNPAILQDANTIKIVGNIMKTNVAACSSIGTYFYSQIGRIYHDMLNMYRAASQLINDAVASDGAIAPKTPKVRGLRTIKKEILKLIDTYVDKSDDLEMVNASMVPPLMEAVLIDYARNVPDAREAEVLNAMTTIIHKLHNLMEDKIPAIMDSVFNCTLEMINKDFHEYPEHRVEFFKLLQAVNLYCFQALLKLDAAQFKFVIDSCMWASKHDNREVENTGLTMCLELMNNMAETDQQTSSIFFREFYIPILQDVFFVLTDSDHKAGFKSQAMLLSRMFYFVESGKIQQPIYSPEQAPPGTSNKEFLQEHIANLLHNAFGNLQEAQIKQFVIGLFLYTDDLNKFKTHLRDFLISLKEFSDDNAELYAEEREQAVRDAQVAERDRAMKVGGLLKPSEMDQEDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q239</accession>
    <name>W6Q239_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glutaredoxin, eukaryotic/virial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PROQFM164_S02g000210</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutaredoxin family. Monothiol subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q239"/>
    <dbReference type="STRING" id="1365484.W6Q239"/>
    <dbReference type="OMA" id="GKWIQEV"/>
    <dbReference type="OrthoDB" id="423313at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005801">
        <property type="term" value="C:cis-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005796">
        <property type="term" value="C:Golgi lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004362">
        <property type="term" value="F:glutathione-disulfide reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03419">
        <property type="entry name" value="GRX_GRXh_1_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000093">
        <property type="entry name" value="Glutaredoxin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011899">
        <property type="entry name" value="Glutaredoxin_euk/vir"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014025">
        <property type="entry name" value="Glutaredoxin_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02180">
        <property type="entry name" value="GRX_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45694">
        <property type="entry name" value="GLUTAREDOXIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45694:SF5">
        <property type="entry name" value="GLUTAREDOXIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00160">
        <property type="entry name" value="GLUTAREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="domain" description="Glutaredoxin" evidence="4">
        <location>
            <begin position="168"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="88"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="117"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDM30061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="272" mass="29861" checksum="969A2E917C8956CF" modified="2014-04-16" version="1">MPSSQRRLRLIVVVVIALLFMVFYYTGDASKIQNQKFYRSTLDAMKAKEQAKQAKAQEKIQNPVHALGQNGAAGAGAGDKVPVAAAEKAAVPPATGNEDTEEIPIAGRTKMTVPKKVNQDKPSEVQSEIKSEEEKEREEKAKREREEKERKEAEATTELNAILKRAPVIVFSKSYCPYSKKAKVILLEHYSIEPKPFVVELDQHPLGPYLQALLAQSTGRRTVPNVLVSGKSIGGGDDIAALDQSDELASTLRQMGGKWIVDVSHQAVEKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q2N5</accession>
    <name>W6Q2N5_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Aspartic endopeptidase PEP2</fullName>
            <ecNumber evidence="6">3.4.23.20</ecNumber>
            <ecNumber evidence="16">3.4.23.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Aspartic protease PEP2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="primary">pep2</name>
        <name evidence="24" type="ORF">PROQFM164_S02g000735</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Secreted aspartic endopeptidase that allows assimilation of proteinaceous substrates. The scissile peptide bond is attacked by a nucleophilic water molecule activated by two aspartic residues in the active site. Shows a broad primary substrate specificity. Favors hydrophobic residues at the P1 and P1' positions, but can also activate trypsinogen and hydrolyze the B chain of insulin between positions 'Gly-20' and 'Glu-21'.</text>
    </comment>
    <comment type="function">
        <text evidence="15">Vacuolar aspartic endopeptidase which is probably also secreted and contributes to virulence.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>Hydrolysis of proteins with broad specificity for peptide bonds. Cleaves -Leu-Leu-|-Val-Tyr- bond in a synthetic substrate. Does not act on esters of Tyr or Arg.</text>
            <dbReference type="EC" id="3.4.23.25"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of proteins with broad specificity similar to that of pepsin A, preferring hydrophobic residues at P1 and P1', but also cleaving 20-Gly-|-Glu-21 in the B chain of insulin. Clots milk, and activates trypsinogen.</text>
            <dbReference type="EC" id="3.4.23.20"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Vacuole lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 21">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.23.20" evidence="6"/>
    <dbReference type="EC" id="3.4.23.25" evidence="16"/>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q2N5"/>
    <dbReference type="STRING" id="1365484.W6Q2N5"/>
    <dbReference type="OMA" id="KYDHDAS"/>
    <dbReference type="OrthoDB" id="771136at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005775">
        <property type="term" value="C:vacuolar lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000036">
        <property type="entry name" value="Vacuolar aspartic protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000002">
        <property type="entry name" value="Vacuolar aspartic proteinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF51">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 21" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="12 20" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11 21" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 21 24" id="KW-0645">Protease</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 22" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0926">Vacuole</keyword>
    <feature type="signal peptide" evidence="22">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004881243" description="Aspartic endopeptidase PEP2" evidence="22">
        <location>
            <begin position="20"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="23">
        <location>
            <begin position="86"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="active site" evidence="19">
        <location>
            <position position="104"/>
        </location>
    </feature>
    <feature type="active site" evidence="19">
        <location>
            <position position="288"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="20">
        <location>
            <begin position="117"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="20">
        <location>
            <begin position="322"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00052037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00055395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00067071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00079414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00079734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="CDM30585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="399" mass="43496" checksum="0E2C37E4C19B510B" modified="2014-04-16" version="1">MMKSFTILAASALLGSAAAEVHKLKLNKVPLSEQLDTHNIDAHMHNLGQKYMGIRPEKHQDLFHDTSLNPASGHNVLVDNFLNAQYFSEITIGTPPQTFKVVLDTGSSNLWVPSSQCSSIACFLHSKYDSSSSSTYQKNGSEFEIRYGSGSLSGFVSKDTLQIGDLKIEGQDFAEATNEPGLAFAFGRFDGILGLGYDTISVNKMVPPFYHMINQKLVDEPVFAFYLGDADKDGDNSEATFGGIDESHYTGELIKIPLRRKAYWEVELNSIALGDNVAELENTGVILDTGTSLIALPSTMAELLNKEIGATKGFTGQYSVECDKRDSLPDLTFTLGGHKFTIGPHDYILEVQGSCISSFMGMDFPEPVGPLAILGDAFLRRWYSVYDVGNNAVGLAKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2024-10-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q2R6</accession>
    <name>W6Q2R6_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S01g002320</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q2R6"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM28509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="57" mass="6255" checksum="8FB8C5EDE3FE0BD2" modified="2014-04-16" version="1">MTGIDMMEPSCPGAVPTKTIVQTQRQVQNATIITAALTGAPSRDRLRVYARSMEYEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q3E2</accession>
    <name>W6Q3E2_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Ras-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">rasA</name>
        <name evidence="10" type="ORF">PROQFM164_S02g000970</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Ras family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q3E2"/>
    <dbReference type="STRING" id="1365484.W6Q3E2"/>
    <dbReference type="OMA" id="CCGGCVI"/>
    <dbReference type="OrthoDB" id="5976022at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04138">
        <property type="entry name" value="H_N_K_Ras_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000080">
        <property type="entry name" value="Ras-like GTPase Ras1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0636">Prenylation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDM30820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="213" mass="23891" checksum="038D15FDBF04EF13" modified="2014-04-16" version="1">MASKFLREYKLVVVGGGGVGKSCLTIQLIQSHFVDEYDPTIEDSYRKQCVIDDEVALLDVLDTAGQEEYSAMREQYMRTGEGFLLIYSITSRQSFEEIMTFQQQILRVKDKDYFPIIVVANKCDLEKERVVSEAEGEALARQFGCKFIETSAKSRINVENAFYDLVREIRRYNKEMSSYPSGSGAFGARAPEGKMDVAEPGESAGCCASCVIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q3M5</accession>
    <name>W6Q3M5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Aflatoxin biosynthesis regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PROQFM164_S02g001075</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q3M5"/>
    <dbReference type="STRING" id="1365484.W6Q3M5"/>
    <dbReference type="OMA" id="FCYRIEA"/>
    <dbReference type="OrthoDB" id="10067394at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47431:SF2">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47431">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00755">
        <property type="entry name" value="AFLATOXINBRP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="16"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="540"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="552"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM30925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="607" mass="68145" checksum="3A5FF61094A3ED29" modified="2014-04-16" version="1">MTPTRSTKTSGLASLACTECRKQHLKCDASKPSCSRCVQNGLLCQYLPSRRGGRRKSRLESPYQRHPQTHVNTRYQSTVPVLPIAPAQTPENPSAQAGRQAGLDITTEPVSWPVMLSDNAPTQQTVGSTRKLSLHDDRLPRLYYENFHVAHPILVPSSLYHDHNYPHFLQLTVHFVGSHYITSIPSQPYKEQVVAELKTNPDRSASMVQAWLLYSIALYARDEWDEAQDALSHSIDIALELGMNRWSFASSTNPERSLEAESMRRTWWELYVTDIFMAVPLKTTTFRCSTVSPEVALPCEESAYNCAGDIPKPRMMIEFKRRILAAEDTVFSSFSYRIEATTILCRVLVLNRLRDCHRDHLQAVENALVSWINHLPPKKLDIVDSYGNVDEMMFQAHLTIAYAAMLLHLPRSDLPSVLSHSQPDDRFWPGLTGQLSSTFTRLVHSIKATEASRRISDSISVCPNVSKHTPFSIPALTLCGLIQLATSTSHSEECFDHHCNRVTLILGCLKSTQRTWKLAESLYHALRSSAAEVLSDSMGKWNSEPLHRPTPAATTPNDQERPSSSGNPPPAMPDGHDFMPPEFSLAFIDPTCYNTSFFSAIPDFDIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q3Y7</accession>
    <name>W6Q3Y7_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PROQFM164_S02g001453</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="Proteomes" id="UP000030686">
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS quinate transporter QutD"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
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        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF7">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="7"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="198"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="290"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="319"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="347"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="395"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="431"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="462"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="10"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDM31303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="549" mass="60181" checksum="B7BBE871FA74EAF2" modified="2014-04-16" version="1">MFVVGNLYAITAVSVIGGALFGFDISSMSAIIGTPAYKCYFNHGPRGPPFNDDDVCSGLSTLAQGGVTAAMPGGSWLGALISGFISDRLGRKYAIMVGCVLWVIGSVIVCASQNMGMLIAGRVINGLSVGIESAQVPVYISELSPPSKRGRLVGSQQWAITWGILIMYYISFGCSFIGHGNSSTSHNYSESVFRIPWGVQAVPAVLLFFGMMVLPESPRWLARKDRWDECQAVLTLVHGKGDMNSPFVLAEMQEIRDICEFERENKDVSYLELFEPRMIHRTMTGIWTQIWSQLTGMNVMMYYITYVFTMAGYKGDATLLASSIQYIINVVMTMPALIWVDRWGRRPTLLIGAVFMMIWMFANAGIMAKYGVIVPGGIDGVAEASMLLSGAPAKGLIACTYLFVASYAPTWGPVSWVYPSELYPLRVRGKAVALATSFNWAFNTALGLFVPTAFATIRWQTYIIFGVFLFAMTIHVFFLFPETSGKTLEEIEQIFEDPNGIPYIGTPAWKTTHDTKRTMAAESGDIEILGEKLAGADKRAATHAEVVDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q4Q3</accession>
    <name>W6Q4Q3_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Nucleolar protein 12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PROQFM164_S02g001101</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRP17 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q4Q3"/>
    <dbReference type="STRING" id="1365484.W6Q4Q3"/>
    <dbReference type="OMA" id="EWDGFPD"/>
    <dbReference type="OrthoDB" id="551633at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019186">
        <property type="entry name" value="Nucleolar_protein_12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14577">
        <property type="entry name" value="NUCLEOLAR PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14577:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09805">
        <property type="entry name" value="Nop25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="37"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="88"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="132"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="44"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="99"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="135"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="189"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="205"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDM30951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="220" mass="25691" checksum="71632C33CBBB21BD" modified="2014-04-16" version="1">MGPKDLKKRKIVAGPKVEEVNFDDESRHEYLTGFHKRKVQRAKHAQDNAAKRYKEEKREARKKIREDRKRDFEQAMAEHKAVLKRMKEDAGDLGAMEGEKEEEDWEGIEEPPAVDYEAEYVDEDKYTTVTVEEMDASREGLLKAARGEDSENEEEKKYPVESTEDDTKAKKRKPRSAASEAARKKKRNFRYETKVERKQTMLKQRAVKAKRAKARKGAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q5E9</accession>
    <name>W6Q5E9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Dynein regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PROQFM164_S02g002034</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q5E9"/>
    <dbReference type="STRING" id="1365484.W6Q5E9"/>
    <dbReference type="OMA" id="FGQWTIT"/>
    <dbReference type="OrthoDB" id="63070at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080008">
        <property type="term" value="C:Cul4-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000557">
        <property type="entry name" value="WD repeat protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051859">
        <property type="entry name" value="DCAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19847">
        <property type="entry name" value="DDB1- AND CUL4-ASSOCIATED FACTOR 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19847:SF7">
        <property type="entry name" value="DDB1- AND CUL4-ASSOCIATED FACTOR 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="384"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="431"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDM31883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="682" mass="77669" checksum="DB84A1D548116C2B" modified="2014-04-16" version="1">MSSRTPDNGRESPRGPEGIWHPAHEWLEDDELDPDYHPALEPSQDDGAWEDDTLNDQQMRSEGASGYNHINLENIQIELTADDSESEDTGNLNEGRTRIPASRLFELLASSGLQHILQANGWPSAMEEEQDQMEDEEDDFVGDDDFLPMFRNRLRARRSAETLKLPPVPNPEGKKLMSEGHFGTDQFYVDRLRQRKKSLATSLMWRELGIDTDGVQKRANQSISQGLIPSSIADMIIHYDTRSYSGQFSDDGNFFFCCAQDFKVRMYDTSNPYDWKYYKTVDYPFGQWTITDATLSPDNRFLVYSSIRSQAYMASTDPEDDSDPTVLDFSAPPGRRSRRSWGSSHFGIWSLRFSGDGREVVAGTSEDSVIVYDLETRQPVLNLRDRHQHHVNAVCYGDTSSPHILYSGSDDTTIRVWDRRSMGDGREAGAFMGHTEGLTYVDSKGDGRYVLSNSKDQTMKLWDLRKMMTTADIENIDPVDYTTGFDYRFEQYPDQFRRNAKNDCSVVTYRGHRVLKTLIRCHFSPPGSTNSRYVYSGSEDGKVYVYNLDATLAGTIDVGQATLNSRPRDPDAYATAYEMSGEMLWRTCVRDASWHPSAPMLAATSWNGWGLSTGTCTVHSWNAGATKDEGDPPLGKSYDDRLRYIPEFNRFHENAVNARPRRPLRSRPVRRWADEEAEDTIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2024-10-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q5F1</accession>
    <name>W6Q5F1_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S02g002039</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q5F1"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM31888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="34" mass="3749" checksum="6C9A99F670548C5A" modified="2014-04-16" version="1">MMHVSDLQLETVWAGSAEGLFVGNIGPDELDWCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q5M0</accession>
    <name>W6Q5M0_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Mpv17/PMP22</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PROQFM164_S02g001406</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the peroxisomal membrane protein PXMP2/4 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q5M0"/>
    <dbReference type="STRING" id="1365484.W6Q5M0"/>
    <dbReference type="OMA" id="KMAIYGA"/>
    <dbReference type="OrthoDB" id="860at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007248">
        <property type="entry name" value="Mpv17_PMP22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266:SF93">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN 25D9-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 2, PXMP2 MPV17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04117">
        <property type="entry name" value="Mpv17_PMP22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="127"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="191"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM31256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="238" mass="26648" checksum="C30D6939993915B1" modified="2014-04-16" version="1">MSVKFQEETVRTVTGGGKSEDLAHRVGERLTGGKTAAGYLQAYLLQLQKNPLRTKMLTSGVLSGLQELLASWIAHDVGKHGHYFSSRIPKMSLYGMFISAPLGHVLIGILQKIFAGRTSLKAKILQILVSNLIISPIQNSVYLTSMAIIAGARTIHQVRATVKAGFMPVMKVSWITSPLCLAFAQKFLPEHTWVPFFNVVGFFIGTYVNTHTKKKRLEALRKRYDQRRDPSYEKRDFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q5Q7</accession>
    <name>W6Q5Q7_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transmembrane BAX inhibitor motif-containing protein 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">TMBIM4</name>
        <name evidence="7" type="ORF">PROQFM164_S01g003386</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the BI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q5Q7"/>
    <dbReference type="STRING" id="1365484.W6Q5Q7"/>
    <dbReference type="OMA" id="FGVMSLY"/>
    <dbReference type="OrthoDB" id="7933078at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd10429">
        <property type="entry name" value="GAAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006214">
        <property type="entry name" value="Bax_inhibitor_1-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23291">
        <property type="entry name" value="BAX INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23291:SF50">
        <property type="entry name" value="PROTEIN LIFEGUARD 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01027">
        <property type="entry name" value="Bax1-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="158"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM29574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="273" mass="30745" checksum="F50CF7A31798EE28" modified="2014-04-16" version="1">MAANTRYEPAPQRDSLDDPSYSRAPPSYEATAAPAESTPRGEDDNLPDDFKFGGTVAEGTIDIRMQFVRKVYSILTAQLLLTTILSSISFFNDSYRTWIQSNFWLMIISVFGALGFMLATFWKRKSYPTNLLFLSGFTILEAYSISVATSFYDAKVVVQALALTLGIFVALTLFACQTKYDFTDWMPYLFGALWFMVLFGFVAMFIPFNSTMEIIYGVLGALVFSGYILVDTQLVMRHYHVEEEIAASISLYLDVLNLFMSILRILNGANNNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q650</accession>
    <name>W6Q650_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alcohol dehydrogenase superfamily, zinc-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S02g001921</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q650"/>
    <dbReference type="STRING" id="1365484.W6Q650"/>
    <dbReference type="OMA" id="WIKYPFI"/>
    <dbReference type="OrthoDB" id="48317at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
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        <property type="project" value="InterPro"/>
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            <begin position="80"/>
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        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CDM31770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="439" mass="46789" checksum="FF76B760512063A7" modified="2014-04-16" version="1">MASSQNVANLDVAHPDVAHPDVAQPEVDHLGVAQQDVAHEDISHQDVAKHVAHQSVARQDASAFNQAPFNQAAWLTTKSGRPLKIGIAPFTPPSAHQIIVKNGAVAVNTVEWTKKLMGNMMSPWVRYPFVLGNDCAGEVVQVGDMVSRIKVGDRVLAHALSMDPAVNKSSEGAFQIYTVIRDNMVTVIPDWLSYEEACVIPLGLSTAATALFHRDFLSLNLPGTPPGTGPEWLPEVVLVWGGSTSVGCSAIQLAAAAGYEVIATCSPKNFEYVSNLGACAVFDYRDKATIQQIVELLENKKVVGAIAVGDDSTDACIEVLAKTNGSKFVARACFPPPKRIISTTFQLFRAVAASVRSNIKTFIKAKRSGVKTKFISGTSAAHNEVGAMVYDHFLPGALATGVFVAAPKPRIVGKGLSQIQLAMDCHMRGEAAQKAVVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q6C6</accession>
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        <submittedName>
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        </submittedName>
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    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR 38B"/>
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    </dbReference>
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            <begin position="65"/>
            <end position="302"/>
        </location>
    </feature>
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        <location>
            <begin position="92"/>
            <end position="115"/>
        </location>
    </feature>
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            <begin position="162"/>
            <end position="177"/>
        </location>
    </feature>
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            <begin position="201"/>
            <end position="212"/>
        </location>
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        <location>
            <begin position="213"/>
            <end position="222"/>
        </location>
    </feature>
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        <location>
            <begin position="223"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM31875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="435" mass="50554" checksum="5DE42C33A76F09F0" modified="2014-04-16" version="1">MDDEYVAQILAKEAKESSIKYASQGMSAFMPSRPTSNAPKPNTRFLRNLIKVTDSHNTALKLKEEREARQRMRQLKYQASGASGALVPTSTDRSDDRSKVRGSRDHRRGDREDRNRSHRKRTRSRSPSAERDRSRRHRRANEEYDGSGEKDKSRDRHRRDHRDHESMRDQRDGDKEHTRRRRERSYSRSPSRSPRRDRSTDRHRHRRQKRQSGHSARSISRSRSPESYKSRRPKREDASPHGSRRSRLEPSTRHRRLSPLSPLATLTARQNELGNESDPLEDLVGPLPPRQNEPPIRSRGRGVYKHSMSNIDAHFAPGYDPATDVHLDENRLDSMGQESSRRPVAGLMTKDDDWDMAMEALRDRERWRSKGEERLRTAGIDEAVIDKWKNNTAFAGVDGESKPEDVQWSKKGEGREWDRGKFVDGDGHIDIRAAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q796</accession>
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        <submittedName>
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        </submittedName>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q796"/>
    <dbReference type="STRING" id="1365484.W6Q796"/>
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    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
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        <location>
            <begin position="68"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="286"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="350"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="514"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="84"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="293"/>
            <end position="302"/>
        </location>
    </feature>
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        <location>
            <begin position="368"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="524"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM31836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="544" mass="61275" checksum="7B8DA423901FA67D" modified="2014-04-16" version="1">MESHTGPIFDEAQYRTDVLHHPSPESEAAQAQHLAEEAQQLGLKVPEIAASAPLAASIASGMVDLSSPVLSSGSSTDRNSVCGSVTPSHEPSSPVPSVLDDIVSSLSDVALSSDRIKTGSTRSLASLSTRPTSFCSSEGRTGLLAPGYNDPFANLHRHSILSVASDDKKGRRRSSFKSAIGRINFRKKRTSSAIFLPSEDRITVSTSDKDLEHVFFEPKPEPVIAAHENVIPHASNEVTLPRLEIPRFSKEELQRSLEDPDLSEMHERHQMERNRHLAFQHAALSTLRRRHQTAVSEQQSDNQRQEDEKREKNIQAIAQIEERQLAVEIEQQREFDRAKMNSRTRIKHMEGYLRNASPPPSPAGTLIRAERSERSERSSESLSESDSTAPARVLTRRHMEQLEQQYHSHKTMDQLHHARIKVLRDRQELKLQEATARMEKELDEMCKRHIKDAAALQLEHQREVNSLMQALETKKTTLRHRWYLEEAVLRRHLEVRHGQSYGPLPLVAFTTPNTPISVKERSPLETSTPDSTPDTIHPKDCVPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q7M9</accession>
    <name>W6Q7M9_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PROQFM164_S02g002516</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q7M9"/>
    <dbReference type="STRING" id="1365484.W6Q7M9"/>
    <dbReference type="OMA" id="RVWVNQL"/>
    <dbReference type="OrthoDB" id="1875751at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050502">
        <property type="entry name" value="Euk_RNA-bind_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48025">
        <property type="entry name" value="OS02G0815200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48025:SF1">
        <property type="entry name" value="RRM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="74"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="185"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="160"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="252"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="307"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="42"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="252"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="309"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="338"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDM32365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="368" mass="41262" checksum="98BC677CFB8B9D59" modified="2014-04-16" version="1">MSELTEVSQKKRKLQDGPELEIDVSAPEPVSKKALRKAKKNKGGDAGDEEKPKSSKSSKPESKEAESDGKRSKYGIWIGNLSFSVTSEELRMFFTVNADISESNITRIHLPKGPERFGRSQNKGFAYVDFTDKKSLQEAIGLSEQLMTGRRVLIKDANNYEGRPDKSEAQANAAGAAKSGHPPSKRIFVGNLSFDVTKENLEENFAKCGTVNNVHMATFQDTGKCKGYAWVEFEELAAAEAAVRGFMLIKQDDEEEDSSDSDSDSASEKKKSKKLKPRVQRVWVNQLMGRRMRMEFAEDAGTRYKKRFGKDAEKKDEPAITEVDGESRERPRHKKRRESIDESRYSKETVQKLSGAIVEGQGQKITFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q8G3</accession>
    <name>W6Q8G3_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">SAGA complex subunit Spt7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PROQFM164_S02g000683</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q8G3"/>
    <dbReference type="STRING" id="1365484.W6Q8G3"/>
    <dbReference type="OMA" id="YRRSEAK"/>
    <dbReference type="OrthoDB" id="21449at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046695">
        <property type="term" value="C:SLIK (SAGA-like) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05510">
        <property type="entry name" value="Bromo_SPT7_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22927">
        <property type="entry name" value="HFD_SPT7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000072">
        <property type="entry name" value="Transcriptional activator spt7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.10:FF:000032">
        <property type="entry name" value="Transcriptional activator spt7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018359">
        <property type="entry name" value="Bromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006565">
        <property type="entry name" value="BTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037782">
        <property type="entry name" value="Spt7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47343">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR SPT7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47343:SF1">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR SPT7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07524">
        <property type="entry name" value="Bromo_TP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00633">
        <property type="entry name" value="BROMODOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 8" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Bromo" evidence="11">
        <location>
            <begin position="339"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="87"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="443"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1033"/>
            <end position="1124"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="280"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="185"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="451"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="465"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="481"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00093633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDM30534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="1124" mass="123802" checksum="BB4C437080E66687" modified="2014-04-16" version="1">MSLGHNAWPPGNIRPPDDLQESPRPVNGLVKTLSGSRTPQIRGSVGAEAPNPSSISEADIAPEEDPRIAQFRELYRRSEAKINALFSGRYSGDNPAAGEATESSEAQPERVDNAPPPSTAPRKSARKLDDDDYDDYDDDDDEDEEMDNAVESPLETKSAAASQEPSGAAPLARRPSTSISAIADGLKEPKKETMEDLRKQLEEDKKATEEAARRSFHTLFYTLENDRDAMLDQQRLEESERQVEAEISGQANMGANNVSGASNGYSSLSNTNLGASSLTLKNLIARIDKKRDRVQASDAELRSLLSEVRKNRSKWANEDKVGQEELYEAAEKVLSELKAMTEHSTAFLTRVNKRDAPDYHTIIKHPMDLGSMTKKLKGLQYRSKQDFADDLTLIWANCLKYNTNTEHPLRKHALYMRKETEKLVPLIPDIVIRDRAEVEAEERRLQLADNDGAEESDDEPIMSSRGRKAPGKKSSKKGTAPSRNTPSPSRAPSTQPTAPARADSDATGEASQNGFFTPPPASNTSSDPAGLGAIATTSQDDSMDIDGPSMSTTALSAMSVSGGVEPEDPEYKVWKQVTKRDRARVAAERHRLLRGDKLNSEEPALLRSKAGMRRWLRHQKQATIETDKSRDGDSQAMELEAAGESLAEGIEVEEDQMLPYYYDVMSGVPDLPDRLLWKEDAQGNVVDASEEFLRMLPTGQFIQPDSKLTRKMNSNMRQMQETRKICSKIGIVKQMQLQSQMYQNQFQKYQPEPFLEQDIEPHVMNDNGPVIAPWVCRAALQRSVAKVFYHTGFEEYQPSALEAVTDIAADFFHKLGSTFKSYMETPKVPTTESHEATPSAAEWKPAYTRSEIVLHTLSTVGIHIDELESYIKDDVDRLGSKLATAHDRLRSLLTELLRPALEGGEDGSNAFADGSEQFVGGDFAEDIDEDFFGFKELGLDREFGLSTLSVPLHLLQNRMFNAANPQNTSVSPTVTLFAPPPPYGRISTDNFSHQIGLLHEFFKGKLDANGDEPLVEDLELPPKQRPMGIKPRLPASGKIPMSSHLGLTSSPHKRAAQAMASKSGGAEPSKKKAKKNIGVAIEMPNFQPDGEGDQATGDPATNSNMKTEETGLVDGTGESMTNGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q8U8</accession>
    <name>W6Q8U8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Probable transposable element</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PROQFM164_S02g002946</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q8U8"/>
    <dbReference type="STRING" id="1365484.W6Q8U8"/>
    <dbReference type="OMA" id="DYCRINE"/>
    <dbReference type="OrthoDB" id="4236307at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.10.10:FF:000007">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 17.6-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053134">
        <property type="entry name" value="RNA-dir_DNA_polymerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24559:SF444">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24559">
        <property type="entry name" value="TRANSPOSON TY3-I GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="8">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM32795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="135" mass="15199" checksum="E5705946B710156D" modified="2014-04-16" version="1">MCIDYRALNELTAKNGYPLPRIQDLLDIVGKAKYLSKIDLASGYWQVRLSEDAVEKTAFNTIWGKYQWRVMPFGLCNAPATFQTMMNETLRDFLGDSVVVYLDDILVFSESLEEHCQHLSLAPTAASAVFLIVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q931</accession>
    <name>W6Q931_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PROQFM164_S02g002662</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q931"/>
    <dbReference type="STRING" id="1365484.W6Q931"/>
    <dbReference type="OrthoDB" id="4364931at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052374">
        <property type="entry name" value="SERAC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48182">
        <property type="entry name" value="PROTEIN SERAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48182:SF2">
        <property type="entry name" value="PROTEIN SERAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM32511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="101" mass="11095" checksum="540CE4F2DA257B45" modified="2014-04-16" version="1">MPLGLHVLHSHNISHRAADLDQNAGVDIVAVHGLGKNSLETWTHHETGTLWLRDLLPRSIHNARVLTFDYDASPSLYTGKDSMDRVQSQATTLVADLEASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q967</accession>
    <name>W6Q967_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transposable element</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S02g003096</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q967"/>
    <dbReference type="OMA" id="CAWIKEA"/>
    <dbReference type="OrthoDB" id="5403091at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022085">
        <property type="entry name" value="OpdG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053204">
        <property type="entry name" value="Oxopyrrolidines_Biosynth-assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38797">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP85-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38797:SF7">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12311">
        <property type="entry name" value="DUF3632"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004879659" description="Transposable element" evidence="2">
        <location>
            <begin position="20"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM32945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="127" mass="14420" checksum="089B9A0EDC3757E8" modified="2014-04-16" version="1">MSGIHLLNFSSFLAKLAFTCVCKDRMCQVALVLFRRTFEERQVLRSSGDPGDPDDEDPHRSMDSLEIRHLLPSATAWLREADCNILQLSEVSWNDCPSAIGKGGRCFIESKLGKRSPTGFTPWRWLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q9F0</accession>
    <name>W6Q9F0_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Molybdopterin binding</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S02g000969</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q9F0"/>
    <dbReference type="STRING" id="1365484.W6Q9F0"/>
    <dbReference type="OMA" id="MARMPRG"/>
    <dbReference type="OrthoDB" id="448496at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047884">
        <property type="term" value="F:FAD diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042726">
        <property type="term" value="P:flavin-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00885">
        <property type="entry name" value="cinA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="entry name" value="MoaB/Mog-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056596">
        <property type="entry name" value="FLAD1_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001453">
        <property type="entry name" value="MoaB/Mog_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47675">
        <property type="entry name" value="MOLYBDOPTERIN BINDING DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G11210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47675:SF1">
        <property type="entry name" value="MOLYBDOPTERIN BINDING DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G11210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24102">
        <property type="entry name" value="FLAD1_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00994">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00852">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="Molybdenum cofactor biosynthesis proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MoaB/Mog" evidence="1">
        <location>
            <begin position="53"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM30819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="331" mass="36316" checksum="32606FDD244EB681" modified="2014-04-16" version="1">MLNRLNLLTRHLSRPFSPSRPISPSFSAPSLAARSGLSAMTSAVHPKLIHTAACLIIGDEVLGGKTVDTNSAFLAKFCFSLGIDLKRIEVIPDDEDDIVEAVRRMSSRYDFVVTSGGIGPTHDDITYSSIAKAFDLKLELHQAAFERMKRLSKPHPLQQNFDWETPSPGLTAKLRMVELPFDPKIPAESQAVFVADDLWVPIAVVNGNVHILPGVPRLFERLLLSLKPSLIPRLTDPEGKGTFRLLFSTPLPESAVAPYLTELAARVKARGVKVGSYPRWGKKRNTVTLVGADKAYMDSLASEVAENVQGTLVATEDELDCPSDEDRVYSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q9I9</accession>
    <name>W6Q9I9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Protein phosphatase 1 regulatory subunit SDS22</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">sds22</name>
        <name evidence="8" type="ORF">PROQFM164_S01g000246</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SDS22 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q9I9"/>
    <dbReference type="STRING" id="1365484.W6Q9I9"/>
    <dbReference type="OMA" id="EVWASYN"/>
    <dbReference type="OrthoDB" id="266138at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000055">
        <property type="entry name" value="Protein phosphatase 1 regulatory subunit 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000446">
        <property type="entry name" value="Protein phosphatase 1 regulatory subunit SDS22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025875">
        <property type="entry name" value="Leu-rich_rpt_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050836">
        <property type="entry name" value="SDS22/Internalin_LRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003603">
        <property type="entry name" value="U2A'_phosphoprotein32A_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46652">
        <property type="entry name" value="LEUCINE-RICH REPEAT AND IQ DOMAIN-CONTAINING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46652:SF3">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12799">
        <property type="entry name" value="LRR_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00446">
        <property type="entry name" value="LRRcap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="U2A'/phosphoprotein 32 family A C-terminal" evidence="7">
        <location>
            <begin position="319"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="18"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="24"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM26437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="343" mass="39221" checksum="016E15E1C5D601FE" modified="2014-04-16" version="1">MKNKEGWDGKMRMERKAVITNPEALEDSDYSDPDAPPVDEIEADEDLLAEEDVNAEDIDLVHCRISSISALKLERFPKLQRLCMRQNQISRINFPPNVAASLTELDLYDNLISHINGLEEFHNLTSLDLSFNKIKHIKNVSHLKKLTEIFFVQNKISRIEGLEELTEIKNLELGANKIREIENLETLTALEELWLGKNKIVEMKNLDSLSNLRIISIQSNRLTKITGLSALPKLEELYLSHNAVTDLSGLESNETLRVLDFSNNQVSHLEHLSSLKNLEELWGSNNQLASFQEVERELKDKEKLQTVYFEGNPLQLNGPAVYRNKVRLALPNIQQIDATFVRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q9L9</accession>
    <name>W6Q9L9_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">L-2-hydroxyglutarate dehydrogenase, mitochondrial</fullName>
            <ecNumber evidence="7">1.1.99.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PROQFM164_S01g000276</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>(S)-2-hydroxyglutarate + A = 2-oxoglutarate + AH2</text>
            <dbReference type="Rhea" id="RHEA:21252"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:16782"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="EC" id="1.1.99.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the L2HGDH family.</text>
    </comment>
    <dbReference type="EC" id="1.1.99.2" evidence="7"/>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q9L9"/>
    <dbReference type="STRING" id="1365484.W6Q9L9"/>
    <dbReference type="OMA" id="GVHFTRM"/>
    <dbReference type="OrthoDB" id="498204at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047545">
        <property type="term" value="F:(S)-2-hydroxyglutarate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43104">
        <property type="entry name" value="L-2-HYDROXYGLUTARATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43104:SF4">
        <property type="entry name" value="L-2-HYDROXYGLUTARATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="9">
        <location>
            <begin position="102"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00036066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDM26467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="475" mass="51416" checksum="AC4B72F0D007D555" modified="2014-04-16" version="1">MMKDENLWFDISIVPGSHTFEFQYMGLGITPDVIPEVIPEVGGRMFLPKSHFRAPSLQAAGQLRLPDMSARALLKQQFKLINKLPTRCFSSTRPTNADFTHAVIGAGVVGLAAARQLAAREGTSTILLERHDAPGTETSSRNSEVIHAGLYYPATSLKTQLCIRGRNLLHDLCAQNNIPHRNTKKWIVAQNPTQWEACLKLHAHAQGLGDAPTRLVGRDEAQQREPDVKADAGIVESETSGIVDSHSLMTYLHGDFEDRGGDVAFKTRVTGVEAIDGGRGGYKITAVSDEDGSVTSFTAETLINSAGHGACDISNMLLPKERHFVPHYAKGTYFSYAASRPRTSVLVYPVTLPGTGGLGTHLTLDMAGRIRFGPDVEWVDSPDDLVPSAARLEQALPEIKAYMPGVDVSAIALDYCGIRPKLGRNGAVNEGKGFQDFIIQEEEGLPGFVNLLGIESPGLTSCLAIGEMVDGILYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q9Y0</accession>
    <name>W6Q9Y0_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Manganese/iron superoxide dismutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S03g000187</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q9Y0"/>
    <dbReference type="STRING" id="1365484.W6Q9Y0"/>
    <dbReference type="OMA" id="MTAREPN"/>
    <dbReference type="OrthoDB" id="275227at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.55.40.20">
        <property type="entry name" value="Iron/manganese superoxide dismutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019832">
        <property type="entry name" value="Mn/Fe_SOD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036324">
        <property type="entry name" value="Mn/Fe_SOD_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036314">
        <property type="entry name" value="SOD_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43595">
        <property type="entry name" value="37S RIBOSOMAL PROTEIN S26, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43595:SF2">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02777">
        <property type="entry name" value="Sod_Fe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54719">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46609">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD), N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Manganese/iron superoxide dismutase C-terminal" evidence="2">
        <location>
            <begin position="222"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM33463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="298" mass="33706" checksum="A984ADE5034E036D" modified="2014-04-16" version="1">MFNRFARPQSALRAASSFSPKPTSAFSRFQTRAIHRIPQLQHDAYYKENGVPEFLSPEAFDFSWTQYQSLLVNKLNLLTQDTVDADAKPGELLVKYSKRPEMASVFNYASMAHNNHFFFNCLSPTATSVPEKFAKDIVDTCSSVESLKLDFLATASSMFGPGFVWLAKNLEREGMMHIFCTYSAGSPYPAAHSRRQPVDMATHTPETQLGNQFAGSMGAHAQNQKSLAPGAVDVQPILCVNTWEHAWMMDYGIAGKDEYLERWWDRINWDVVFDNYNAVGSMKNSRNSINRHRSMSML</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q9Y6</accession>
    <name>W6Q9Y6_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S02g002947</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q9Y6"/>
    <dbReference type="OrthoDB" id="10272240at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM32796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="45" mass="5109" checksum="9517F22658B6379E" modified="2014-04-16" version="1">MSSTGALHCYVEETVANYFDDIVLVKEQSPLFGITTVVRKFQSQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W6QA09</accession>
    <name>W6QA09_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cystinosin/ERS1p repeat</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PROQFM164_S02g002977</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QA09"/>
    <dbReference type="STRING" id="1365484.W6QA09"/>
    <dbReference type="OMA" id="ASWEWID"/>
    <dbReference type="OrthoDB" id="75720at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015184">
        <property type="term" value="F:L-cystine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005282">
        <property type="entry name" value="LC_transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13131">
        <property type="entry name" value="CYSTINOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13131:SF5">
        <property type="entry name" value="CYSTINOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00679">
        <property type="entry name" value="CTNS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="48"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="123"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="185"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM32826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="272" mass="30634" checksum="379389FE6B61A9E7" modified="2014-04-16" version="1">MLNDTWTHTVSQILGWTYFILWSLSFYPQVLHNHRRRSMDGFSVDFAVLNILGLTAYTISNACFLFSPVVRAQYAQRHPQGAEPTVQWNDFVYALHGALVCCLIGSHFLYARFWNFQSKSQRVSILAFVVIWACVGVVALAILYVWVSASWEWIDVVYVVGMIKVFLTAVKYTPQAAMNYLRQSTAGLSIVAILLDLTGAALSLMQLVLDSSLQADWSGTTGNIAKLLLGNITVLFDLIFIFQHFVLYQEQPAERKLGLSEHDPLLDSSDEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>W6QAB4</accession>
    <name>W6QAB4_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mitogen-activated protein kinase kinae mkk2</fullName>
            <ecNumber evidence="1">2.7.11.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PROQFM164_S03g000044</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:17990"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:46609"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.24" evidence="1"/>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QAB4"/>
    <dbReference type="STRING" id="1365484.W6QAB4"/>
    <dbReference type="OMA" id="KMLEHPW"/>
    <dbReference type="OrthoDB" id="10252354at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004707">
        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd06621">
        <property type="entry name" value="PKc_Pek1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000294">
        <property type="entry name" value="Map kinase kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000263">
        <property type="entry name" value="MAP kinase skh1/pek1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050915">
        <property type="entry name" value="MAP_kinase_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47448">
        <property type="entry name" value="DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE DSOR1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47448:SF5">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINAE MKK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="203"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="44"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="57"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="115"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="141"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="155"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00071969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDM33320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="495" mass="54001" checksum="33E513D66C4A7046" modified="2014-04-16" version="1">MSSPVPLLRPPVPGARNNTGSPRAPKLTLGIPPSPSAKPVNGNPAPAQVPQIQTQPQPQPRPSGRPAPPRLHLATPMGSQQNVSPPTLMPNGRPAPPPLSTNGLGGGSGGAPILQIQTNGPASSNPSYSTINFAMGLRQPDGSSDPSSAISSVYSDRENGDREHSVNGLLPDLDKLSLEKGRPLDVDDLDDEGWHAASEQNMIVELGSLGEGAGGAVTRCRLKEGKTVFALKIITTDPNPDVKKQIVRELNFNKDCASHHICRYYGAFMDKSTGTISIAMEFCEGGSLDSIYKEVKKLGGRTGEKVLGKVAEGVLNGLTYLHSRKIIHRDIKPSNILLCRDGKVKLCDFGVSGEFGTKGDANTFIGTSYYMAPERITGQSYTITSDVWSLGVTLLEVAQHRFPFPADGTEMQPRAGLIDLLTYIVRQPIPTLKDEPQNGIRWSDNFKYFIECCLEKEPPRRATPWRMLEHPWVQDMKNKKVNMTNFIRQVWDWKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>W6QAG0</accession>
    <name>W6QAG0_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Diphthamide biosynthesis protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">dph4</name>
        <name evidence="15" type="ORF">PROQFM164_S03g000387</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for the first step of diphthamide biosynthesis, the transfer of 3-amino-3-carboxypropyl from S-adenosyl-L-methionine to a histidine residue. Diphthamide is a post-translational modification of histidine which occurs in elongation factor 2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the DPH4 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QAG0"/>
    <dbReference type="STRING" id="1365484.W6QAG0"/>
    <dbReference type="OMA" id="IIGCRGC"/>
    <dbReference type="OrthoDB" id="445556at2759"/>
    <dbReference type="UniPathway" id="UPA00559"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.660.10">
        <property type="entry name" value="DPH Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044248">
        <property type="entry name" value="DPH3/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007872">
        <property type="entry name" value="DPH_MB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036671">
        <property type="entry name" value="DPH_MB_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21454:SF46">
        <property type="entry name" value="DIPHTHAMIDE BIOSYNTHESIS PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21454">
        <property type="entry name" value="DPH3 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05207">
        <property type="entry name" value="Zn_ribbon_CSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144217">
        <property type="entry name" value="CSL zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51074">
        <property type="entry name" value="DPH_MB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="J" evidence="13">
        <location>
            <begin position="9"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="DPH-type MB" evidence="14">
        <location>
            <begin position="129"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="55"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00021797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CDM33663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="201" mass="22102" checksum="56F6F4BE24BB8A5B" modified="2014-04-16" version="1">MTRTANAVDLYEVLSLSFTGSSSTVLSKQQIKIAYHKALLQHHPDKAGAVARETGLGRSTNSTSASTPNHLSASSDGNSSRQLYTIDQITTAYKTLSDPVLRSEYDRSLRLDRLKVAEREKTGDVFHTGLEIVDLEDLDCEKAEGGDGDCWFRGCRCGDERGFLVSEEDLEREAEHGEIIIGCRGCSLWLKILFAVEADEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W6QAK9</accession>
    <name>W6QAK9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S03g000442</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QAK9"/>
    <dbReference type="STRING" id="1365484.W6QAK9"/>
    <dbReference type="OrthoDB" id="4311613at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43638:SF3">
        <property type="entry name" value="ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43638">
        <property type="entry name" value="OXIDOREDUCTASE, ALDO/KETO REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="65"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM33718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="261" mass="28469" checksum="085B218A23BF09D2" modified="2014-04-16" version="1">MATPGTQYMMQACLAADMSSSPHPKPVDPYLSDPVSMLPPGLTPDSNSRITLRGVSGKDVLIPCLSIGAWSWGDKATFDYNPTRDLPRIHAAWAKLKAVGLTFVDTAQSYGDGESERICGILFRDMPRDSFVVQTKWLSTPDITNTVLQSGGPKSKLKDSLVRLQLDYVDIYLVQGPIHPSKISIVAKGMAGCVKSGMARAVGVANYDTNEMIKMADELAKHDVPLSVCQCEYSVVRRLPEVSGLIRECKNAVFAFKGFPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W6QB80</accession>
    <name>W6QB80_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Rieske [2Fe-2S] iron-sulphur domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PROQFM164_S02g003423</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM33271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QB80"/>
    <dbReference type="STRING" id="1365484.W6QB80"/>
    <dbReference type="OMA" id="KHDWSFD"/>
    <dbReference type="OrthoDB" id="426882at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03467">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="entry name" value="Rieske [2Fe-2S] iron-sulphur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21496">
        <property type="entry name" value="FERREDOXIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21496:SF0">
        <property type="entry name" value="RIESKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="ISP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="6">
        <location>
            <begin position="45"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM33271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="155" mass="17539" checksum="99CA956DF5CC8232" modified="2014-04-16" version="1">MNPFKRATAAWHPVGLASEFPSIDDDARIVPRCKAFNIPKTNDAIERVEDIDLPGELKDQVLVFKYKGKYHAIDHQCPHSSFPLSQGHLFDIEDFGIVLSAGLTCPKHGWSFDLFSGRADRGNYTLKVWEVQLRDSSALGSTDQEVWVRRKQRIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>W6QBM4</accession>
    <name>W6QBM4_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">ATP-dependent RNA helicase ROK1</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">ATP-dependent RNA helicase rok1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">rok1</name>
        <name evidence="18" type="ORF">PROQFM164_S02g001709</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">ATP-dependent RNA helicase involved in 40S ribosomal subunit biogenesis. Required for the processing and cleavage of 35S pre-rRNA at sites A0, A1, and A2, leading to mature 18S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Interacts with the U3 snoRNA and is associated with the 90S and 40S pre-ribosomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DEAD box helicase family. DDX52/ROK1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QBM4"/>
    <dbReference type="STRING" id="1365484.W6QBM4"/>
    <dbReference type="OMA" id="FRAGEIW"/>
    <dbReference type="OrthoDB" id="360161at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17957">
        <property type="entry name" value="DEADc_DDX52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044764">
        <property type="entry name" value="DDX52/Rok1_DEADc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF15">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 18" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="16">
        <location>
            <begin position="213"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="17">
        <location>
            <begin position="465"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="128"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="298"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="640"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="8"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="39"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="79"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="151"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="307"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="320"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="658"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="678"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="690"/>
            <end position="702"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CDM31559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="718" mass="78685" checksum="C044DFAA3ADB9327" modified="2014-04-16" version="1">MDAFRLLTRSTKLKPTSSASDSRLPSTGKAANPQLFRTAETDKLESAKNGKKRKRGAAIQQDEEDVPELDFFSSNKRPAASVTETAAATEDAEKVSAQDAASDDDDSMDEVERRTILNSHKIKVTDMRDLEEIQVQPTSTKESKKKKKKSKKEEAPTLSKKEQKRARRLFPEPLLNFKELRSKYKISSRLAENVAEQGFTVPTEVQLGSLPLLLGESSEPDLLVVAPTGSGKTLSFLIPVINKIVRHHHSNPDEHGILSVVVAPTRELASQIVNEGRKLVAGTGVKITLMRKGMRVGDNGDGNVLDENSEESSGSEDEGAESKPAKERANIPVTKSDILVTTPLMLVNALSANRTTTVATLPLVRSLVMDEADVLLDPLFREQTLDIWKACSHPDLRVGLWSATMGSNIEDLTKSTIRERLEDMGQKPSEPHPLLRLVVGLKDSAIPNIDHKLVYAATEQGKLMGLRQLLRPAAASASDIRLRPPFLIFTQTIPRAVALHSELKYDIPAEAGGSSRIAVLHSDLSDGQRSDIMRDFRKGEIWILVTTDLLARGVDFRGINGVVNYDIPNSAAVYVHRVGRTGRAGREGGIAVTYYTKEDIPYVKSIANIIDVSEKLRGGEEGEKSIQKWLLDALPNLSKNSKKDMKRHGVKARQAPRLTDKEDDGKGARGMRISTKSGFERRMENNKRGAIAASRNRKAAAAVSGNVSDTGSWAGLDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W6QC03</accession>
    <name>W6QC03_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Genomic scaffold, ProqFM164S03</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S03g000952</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QC03"/>
    <dbReference type="STRING" id="1365484.W6QC03"/>
    <dbReference type="OMA" id="LCKTHGF"/>
    <dbReference type="OrthoDB" id="2560628at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056119">
        <property type="entry name" value="DUF7702"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42109:SF2">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42109">
        <property type="entry name" value="UNPLACED GENOMIC SCAFFOLD UM_SCAF_CONTIG_1.265, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24800">
        <property type="entry name" value="DUF7702"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="215"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7702" evidence="2">
        <location>
            <begin position="3"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM34228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="305" mass="34115" checksum="457ABD7E56204CCB" modified="2014-04-16" version="1">MTIDYRHGISILEVIVYSPCLFIALWMAFHHGFKKSSGWYFFNIFCLARVIGAACYLATIRYPSNINLYITWAVCTSLGLSPLLLACLGLLSRANDSIMRKTANPLHPLIFRVVATFSLVGVILSIVGTTQNSDITHGLVTIESKIGLIFYLITWFCVFGLFFLILKRTESIEDGERRLLLAVGISVPLILVRLVYSYIFAFGGDADFNLLSGNVTIQLVMCVLEEILVVLVCLGIGLTLEVRPAAEYTQQPSTHSGEENLMELESGHLPGQARPNRRVQRPKRRGGPITKLVMYIVDEVKDRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W6QC92</accession>
    <name>W6QC92_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GTPase-activating protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">gap1</name>
        <name evidence="3" type="ORF">PROQFM164_S03g000819</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QC92"/>
    <dbReference type="STRING" id="1365484.W6QC92"/>
    <dbReference type="OMA" id="AYMITLN"/>
    <dbReference type="OrthoDB" id="775356at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046580">
        <property type="term" value="P:negative regulation of Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05132">
        <property type="entry name" value="RasGAP_GAPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.10">
        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000593">
        <property type="entry name" value="RasGAP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023152">
        <property type="entry name" value="RasGAP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001936">
        <property type="entry name" value="RasGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14149:SF17">
        <property type="entry name" value="GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14149">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEIN WITH IQ MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00616">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03836">
        <property type="entry name" value="RasGAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00323">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143885">
        <property type="entry name" value="RGC domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00509">
        <property type="entry name" value="RAS_GTPASE_ACTIV_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50018">
        <property type="entry name" value="RAS_GTPASE_ACTIV_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ras-GAP" evidence="2">
        <location>
            <begin position="189"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="10"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM34095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="785" mass="90255" checksum="CB83E5271EDD1291" modified="2014-04-16" version="1">MSVATMLQPASRQSRASSSSSSSFQPVARHNTMSSHDTRSLRQSKRMSVTALYLSMSAKDRDLEISDDLARAQKHLRDLKSRISSQSKKNFVLEKDVRYLDSRIALLIQNRMALEEQNEVASHLDDTADPQEGFFPNDERTQKYGNLLFLLQSEPRHIAHLCRLVSMAEIDSLLQTVMFTIYGNQYESREEHLLLTMFQSVLTYQFDNTPEYSSLLRQNTPVSRMMTTYTRRGPGQSYLKQVLADQINSLIELRDVDLEINPLKVYETMVKQIEEETGSLPDYLARSVTAEDAAENAQVQAIIAPRLKMLTDIANGFITTIIDSVDEAPYGIRWICKQIRSLSRRKYPDAQDQTICTLIGGFFFLRFINPAIVTPRSYMLIDATPTDRPRRTLTLIAKMIQNLANKPSYAKEPYMASLQPFIQQNKERVNKFLLDLCEVQDFYESLEMDNYVALSKRDLELQITLNEMYVMHGLLEKHSTSLAQDQYSHLSLLLQELGGAPPQVPRKENRTITVPLFSKWETALDDLTAALDITQEEVFFMEAKSTFVQIMRSLPQNTLVARRPLRLDRIAEAAATLKNDAVMVRKGIRTMELLSQLQDMGVIDRSDEFSLLRDEVEQELVHLGSLKEKVLEETRKLEEVFATIRDHNAYLVGQLVTYKSYLHNVRSQSEGKNRGGKTPKNQELGPYKFTHQQLEKEGVIRRSNVPENRRANIYFMFKSPLPGTFVISLHYKGRARGLLELDLKLDDLLEMQKDNLEDLDLEYVQFNVTKVLTLLNKRFARKKGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W6QD03</accession>
    <name>W6QD03_PENRF</name>
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        <submittedName>
            <fullName evidence="7">Mitochondrial import inner membrane translocase subunit tim23</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">tim23</name>
        <name evidence="7" type="ORF">PROQFM164_S03g001064</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QD03"/>
    <dbReference type="STRING" id="1365484.W6QD03"/>
    <dbReference type="OMA" id="FQPTPFD"/>
    <dbReference type="OrthoDB" id="159299at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045238">
        <property type="entry name" value="Tim23-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15371:SF0">
        <property type="entry name" value="SD19278P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15371">
        <property type="entry name" value="TIM23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02466">
        <property type="entry name" value="Tim17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="181"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM34340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="204" mass="21364" checksum="A6D3840A2882FC65" modified="2014-04-16" version="1">MSIWDSLSGRKQTGPEAFDPSTAQDATSFLSEVAIPDPSRLHPLAGLNQDTLDYLSLDDTALDELPGSRSVLPSRGWSDDLCYGAGTTYLVALATGGAWGLVEGLKKTPPTAAPKIRLNGVLNSVTRRGPFLGNSAGVVAMVYNGFNSSLGYVRGKHDATNSIVAGALSGMVFKSTRGLKPMMISGGIVATIAGAWAVTRRAFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W6QDD3</accession>
    <name>W6QDD3_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S03</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S03g001209</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QDD3"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM34485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="53" mass="6122" checksum="5FCFA857B1E3490E" modified="2014-04-16" version="1">MFDVEKTHKALKDQDQQGDYWKSVGNKLEDKIFGMSEPSRDGDIPIHFVDPEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W6QDT5</accession>
    <name>W6QDT5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribonuclease III, bacterial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S03g001380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QDT5"/>
    <dbReference type="OMA" id="HFQEHTP"/>
    <dbReference type="OrthoDB" id="4369707at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00048">
        <property type="entry name" value="DSRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="SMART" id="SM00358">
        <property type="entry name" value="DSRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50142">
        <property type="entry name" value="RNASE_3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase III" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM34655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="243" mass="27902" checksum="C56A6C90928548DB" modified="2014-04-16" version="1">MSKFCAQKLEFVGLEWLKLEIVLWLYLYVPQLSNASIFKIRKHLLRNELQYDELLLAIEPTPHFDSSSESAATLFFHNIGTKVIQGYLEPSLSMVPIRVLLSGHLDKRREGIVNLTRSVKECSNRESDNLTLAHFQEHTPYKPWNQEQQLRTKDEMFHQSYSHLAIKQIYEDHKYTSALKEIGDSECCSPEYSLIRLGFDPPRWCAVAQYRGVKSSAEGSSKRAAKHSASKSLWLQMGGEPIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W6QE04</accession>
    <name>W6QE04_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S02g002575</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QE04"/>
    <dbReference type="STRING" id="1365484.W6QE04"/>
    <dbReference type="OMA" id="WGYECIS"/>
    <dbReference type="OrthoDB" id="5392447at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022085">
        <property type="entry name" value="OpdG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053204">
        <property type="entry name" value="Oxopyrrolidines_Biosynth-assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38797:SF4">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38797">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP85-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12311">
        <property type="entry name" value="DUF3632"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM32424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="286" mass="31857" checksum="73AD32AE0D9A51E7" modified="2014-04-16" version="1">MNTSIQEMTCKSIELDGFGSAADDAWFDQHTAPMDGEEETGVHPYQAAALKAYLKGDSKPSETAAALTKPHDSEKKTDLRDRIVGILEDALFELPESHTPALVDLLKELSQLPDEEDGEPVWKGLKSFGHSWADGWKQSHWRKALATRDPATRAKRREAHVHQAFVEASCAMAAPGPNAEDGLLPLSWGYECISEALECQDALWDFEVPAAAVWIKVAGERLRESAKKGEKSWALEREGRLWTAGPMSMDRWKFWLQRLEEIEKIGKVISSTASEGLRDARAQSKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W6QE39</accession>
    <name>W6QE39_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S03</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S03g001730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM35003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QE39"/>
    <dbReference type="STRING" id="1365484.W6QE39"/>
    <dbReference type="OMA" id="VMQIVNH"/>
    <dbReference type="OrthoDB" id="3469225at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540">
        <property type="entry name" value="TRANSCRIPTION FACTOR (ACR-2), PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540:SF5">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM35003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="505" mass="56460" checksum="0AE07B47F5010A7F" modified="2014-04-16" version="1">MDSVDWKSRGAEPPTRDAQILPARPSHGSRMLARKLTSVQPSATQDLRFINLSHPDDLHRQKEVRTEIRRHVMKDIGQRRRRPQPNATSSQATRTFSSESNGYKISQLRGAIINSVSPSQNLAMLAHFPVEADMRALELMHSVVTGPYQPFRGVWIEVALCDPGAFHVTLGNAADFLNKINGNQSVKSPEALSHFEISTRKLRQRLNNFTESISEGAIANILAHVCLTMRHCDWDSWSIHMDGLSLIAKLRGGFADLGHRMSLLILLYDLAGAMVFDSYPRFGLPAEFVGISNISSRGLAPRLQALLVQPISPAFFPAGQALTMVSSIADVINTTSHSASFWKRDIDAIRLIGPCIHFLLSMPRFPSNFEAMADPEDLIARELVRLTCLMLMSKLKGQFAFPPSELVSLPARLAEFVPPNVKRLGKKYFELKIWALVTIALLRYCDGREVYIQEMKREMSAMEKATPYEITGIARDIVWIDILMSPFSEELAADMKLHVTPQGTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W6QEC1</accession>
    <name>W6QEC1_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein kinase-like domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S03g001537</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QEC1"/>
    <dbReference type="STRING" id="1365484.W6QEC1"/>
    <dbReference type="OMA" id="WPEYWEF"/>
    <dbReference type="OrthoDB" id="8300194at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF58">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="2">
        <location>
            <begin position="380"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="276"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="306"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM34810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="612" mass="68774" checksum="354DC0278B18FD90" modified="2014-04-16" version="1">MFVSLEKTTSLASRFQDALPSILKKSRHTEIWGVDLKHAEWQVLEVVLEKFLRCHSAILALQLSRASASLEKTLEWRSLSDPRALLTEAETILPDLDLCHITLNEGQYVLWINIDEMAIKRYSIIHASLTTSGFLVQLGLAVMQKLSVLLMHAAASSDLHDYSASCVVEFKIHAIQNTKRGQQSFQGKISNAIEELVTFIRCHYPKILGKAYIIKPRDEYLATLDINESLLRDTVLLENPEDLARYLGSQLPPRYGGTGESLAECDILPSCSLAEDPTGNNDLKTPDTSAAASTDMEKTGVKEETTASAMNTGSTSPHGLKIEEQKPRLIYSDIIEPPSIILDPEDLPKATNLCPDKMGARVLFADSDTVAKFSHGVRLAEAEALHLASTRTTIATPKLLSAYILDGVGYIIMSYEVGEPLNKYWDRVPKTEQDRVLEQLRDCVNQMREIPGDFIGGVDGSPCRDGVFEAGYGDYTSYSHGPYPSEESFDEGMIQALRDRMPFKVLQGEHDVESSFFNSEYMLYQTVRGIKNHKIVFTHGDLHAGNILVRADGTVVLLDWGLAGFWPEYWEFYRVIHHSPWRPSWDRMVEIFIPPFYVEYSVMKRIFATAWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W6QEF2</accession>
    <name>W6QEF2_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Dyp-type peroxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PROQFM164_S01g001778</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM164</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the DyP-type peroxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QEF2"/>
    <dbReference type="STRING" id="1365484.W6QEF2"/>
    <dbReference type="OMA" id="IPYGPEG"/>
    <dbReference type="OrthoDB" id="3207336at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049509">
        <property type="entry name" value="DyP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048328">
        <property type="entry name" value="Dyp_perox_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006314">
        <property type="entry name" value="Dyp_peroxidase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01413">
        <property type="entry name" value="Dyp_perox_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30521:SF4">
        <property type="entry name" value="DEFERROCHELATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30521">
        <property type="entry name" value="DEFERROCHELATASE/PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21105">
        <property type="entry name" value="DyP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20628">
        <property type="entry name" value="Dyp_perox_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51404">
        <property type="entry name" value="DYP_PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 11" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="domain" description="DyP dimeric alpha+beta barrel" evidence="10">
        <location>
            <begin position="8"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="Dyp-type peroxidase C-terminal" evidence="9">
        <location>
            <begin position="244"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF20628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF21105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDM27967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="528" mass="59851" checksum="36FB702EA761C7DC" modified="2014-04-16" version="1">MAPPNKKNIQGDIWPRLSKKHELFVFFRITNPELFKKHLAALIPNLTTARDAERFRKGIYQKKEEGTLKGLVHMSAINVAFSAKGLAKLGAEAFTDDVFNNGQWEDMTYPLEGDDKKKHNGLDDQHDWFHQFTPRSGYLDGVFTITGESEKTLVDTIKMVEQTFEVGLEVDKPKPSIQLVFRQQGHVLDDDREHFGWVDGISQPVVIGLDTDAKVEEAKKGLKPIQAGAILVGGEGDQGNHPAWANEGSFMVFRTYEQRTPEFVAWCARNTKKVVAEGINERSAAELRKFSSRVVGRWPNGAPLELYPDQDPSPMLNPDPIENKKKLFTQWKKENKDPEAEFKKLEQINHTDAFTYNPEDQTKCPYAAHIRKCGPRDDFPNYEKHLMLRRGIPYGPLTLNNEKAGGVSQHDRGLLFVSYQSSITNGFRFVQKEWANKEDKPVDFTAKMGNIAPQGIDAIIGQMPPDYRAEDDVTKYEHPAPVANFPDVEKPVPTPNKHYIPIERWVIPRGGEYFFAPSISGMQDTLCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W6QEK4</accession>
    <name>W6QEK4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Pyruvate oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PROQFM164_S03g001185</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the TPP enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QEK4"/>
    <dbReference type="STRING" id="1365484.W6QEK4"/>
    <dbReference type="OMA" id="DMCFPGD"/>
    <dbReference type="OrthoDB" id="2867507at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005948">
        <property type="term" value="C:acetolactate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003984">
        <property type="term" value="F:acetolactate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07035">
        <property type="entry name" value="TPP_PYR_POX_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045229">
        <property type="entry name" value="TPP_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme_TPP-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006203">
        <property type="entry name" value="PRK08327.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968:SF164">
        <property type="entry name" value="PYRUVATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968">
        <property type="entry name" value="THIAMINE PYROPHOSPHATE ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Thiamine pyrophosphate enzyme N-terminal TPP-binding" evidence="6">
        <location>
            <begin position="6"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme central" evidence="4">
        <location>
            <begin position="211"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme TPP-binding" evidence="5">
        <location>
            <begin position="421"/>
            <end position="577"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM34461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="599" mass="64356" checksum="88FEC4CDAD3720F3" modified="2014-04-16" version="1">MEAYTASFAFFEALWEGGVSHVFVNLGSDHPSILEAMVKGQKEKKGQFPTIITCPNEMVALSMADGYARLTGEPQAVIVHVDVGTQGLGAAVHNASCGRAPVLIFAGLSPYTIEGEMRGSRTEYIHWIQDVPDQKQIVAQYCRYTGEIKSGKNVKQIVNRALQFATSDPQGPVYLAGAREVMEEDIEPYQLNQAVWGPVSPAALPTSGVELIAAELAAAKRPLIITGYSGRKAQAVTELVALADSFKGIRVLDTGGSDMCFPANHPAWLGLRYPGHEAVGTSDLILVVDCDVPWVPTQFKPSASAKIIHIDVDPLKQQIPVFYIHSMATFRADASTALKQINDYVASRESLQQFISSKDNITMGQRRDEEYSRRRQEISDLAVIPEGGDGASLNIHYLMAQVREGVPIDTIWAIESVTMTHFVADQVSATQPKSWINCGGGGLGWSGGGALGIKLASDIQQGGRGKGKFVCQVVGDGTFLFSVPGSVYWIARRYGIPVLTIVLNNKGWNAPRRSMLLVHPEGDGSRATNEDLNISFVPTPDYAGIAKAAAGGDLWAGRASTVAELARKLPEAIQSVLNGKAAVLEAQLDGTAGKYVESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W6QEM1</accession>
    <name>W6QEM1_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Casein kinase II subunit beta</fullName>
            <shortName evidence="4">CK II beta</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ckb-1</name>
        <name evidence="6" type="ORF">PROQFM164_S01g001843</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 4">Regulatory subunit of casein kinase II/CK2. As part of the kinase complex regulates the basal catalytic activity of the alpha subunit a constitutively active serine/threonine-protein kinase that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Tetramer composed of two alpha chains, one beta chain and one beta' chain.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the casein kinase 2 subunit beta family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QEM1"/>
    <dbReference type="STRING" id="1365484.W6QEM1"/>
    <dbReference type="OMA" id="QNGSPMA"/>
    <dbReference type="OrthoDB" id="2275560at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005956">
        <property type="term" value="C:protein kinase CK2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034456">
        <property type="term" value="C:UTP-C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019887">
        <property type="term" value="F:protein kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006359">
        <property type="term" value="P:regulation of transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1820.10:FF:000004">
        <property type="entry name" value="Casein kinase II subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.20:FF:000001">
        <property type="entry name" value="Casein kinase II subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1820.10">
        <property type="entry name" value="protein kinase ck2 holoenzyme, chain C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016149">
        <property type="entry name" value="Casein_kin_II_reg-sub_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035991">
        <property type="entry name" value="Casein_kinase_II_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000704">
        <property type="entry name" value="Casein_kinase_II_reg-sub"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11740">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11740:SF0">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01214">
        <property type="entry name" value="CK_II_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00472">
        <property type="entry name" value="CASNKINASEII"/>
    </dbReference>
    <dbReference type="SMART" id="SM01085">
        <property type="entry name" value="CK_II_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57798">
        <property type="entry name" value="Casein kinase II beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01101">
        <property type="entry name" value="CK2_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="60"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="218"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="305"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="218"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="306"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="340"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00045899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00062110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDM28032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="367" mass="41046" checksum="A74EE48A3F968B76" modified="2014-04-16" version="1">MSSSEGAPESWISSFCSLMGHEFFAEVSEDFIEDDFNLTGLQSQVPMYKEALEMILDVEPEDDEEEEEEEEEEDEDDALGGEPAYRRAGDRRHARVASDLSVIESSAELLYGLIHQRYITSRPGIQQMLEKYEMQHFGTCPRVNCNGCKVLPVGRSDTPGHETVKLFCPGCMDIYTPPNSRFHSVDGAFFGTTFGCLFFMTFPDLDIGPRLDAALSSISPRNAATQSRTGSLTRTPAGRQARSPTPENQPLEINGVRTPNLCPGLGKGKIYDPKIYGFKVSEVSRVGPRMKWLRMKPKNVVELDEAWNHEHGMSPQEARDDKEGDTEMNPEQSQDAAIANRKKAPMRRRRPNLGALVPTDPMDVHGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W6QEX4</accession>
    <name>W6QEX4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">L-azetidine-2-carboxylic acid acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ppr1</name>
        <name evidence="3" type="ORF">PROQFM164_S03g001330</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QEX4"/>
    <dbReference type="STRING" id="1365484.W6QEX4"/>
    <dbReference type="OMA" id="MEQPMAL"/>
    <dbReference type="OrthoDB" id="10264707at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052742">
        <property type="entry name" value="Mito_N-acetyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43138">
        <property type="entry name" value="ACETYLTRANSFERASE, GNAT FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43138:SF1">
        <property type="entry name" value="N-ACETYLTRANSFERASE ACA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="71"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM34606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="226" mass="24958" checksum="50CD6D45C7626B8E" modified="2014-04-16" version="1">MPSILEDPSTRNPPPKAHLDAAPTLTAWKTTLPKSSAPMTVYPITGGPQTVPKDLIKFLHEEFTAEILRGGTYPMEQPMALDEFANYWFGTFVALAILDDEGEGLREGRDWESVCMGTFYIKPNYPGRCSHICNGGFLTATAARRRGVGQAMGEAYLEFAPRLGYTYSVFNLVFANNPGSIRIWEKLGFSVIGRVPKAARLANSEELVDALIFGRELGNSNGRFQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W6QF09</accession>
    <name>W6QF09_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S03</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S03g001376</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QF09"/>
    <dbReference type="OrthoDB" id="3796275at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM34651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="93" mass="10539" checksum="1E12D464CDF228C8" modified="2014-04-16" version="1">MPNQGRDNRTQTHKEGLAQRWCRGTGASRQALRPRNDNPERVCVGDEHGLQGRFQQAIGQEFGAVLEAKWVEFSFADFKCSGSGYKKRPMLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W6QG72</accession>
    <name>W6QG72_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily domain, general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PROQFM164_S04g000679</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QG72"/>
    <dbReference type="STRING" id="1365484.W6QG72"/>
    <dbReference type="OMA" id="CAWVGFF"/>
    <dbReference type="OrthoDB" id="28755at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008506">
        <property type="term" value="F:sucrose:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19432:SF35">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 45 MEMBER 3 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19432">
        <property type="entry name" value="SUGAR TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13347">
        <property type="entry name" value="MFS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="117"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="155"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="230"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="295"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="347"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="440"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="466"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="499"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM35798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="615" mass="66871" checksum="9D49F1D61D019EF0" modified="2014-04-16" version="1">MGALNFKPAPGYIDESSPLMVATRSAERRGVRPFAGADESSKNALYMFLLTLSIGGLQIVWSVELSNGSPFLLSLGMSKSLLAFVWIASPLTGALVQPYIGIRSDNCRLAWGKRKPFMVIGGAATVVSLLALAWVKEIVGGVLSIFGVETSAIKIVIIIMATIFMCCLDFAINTVQAAARAFIVDNCPTHQQELSNAWASRMVGVGNILGYIFGYMDLPKVVPFLGNTQFKVLCVLASVFLSTTVAISCIYIQERDPREDGPVTDKLGLVSFFKQVIKSIRSLPTQISRVCEVQIAAWVGWFPFLYYSTTYIGQLYVNPIFADNPHLSEGEVDKAWEDATRVGTLALLIYAIISFLSNMLLPLFVVPLYGPAPETVSQRDSLDGDLDGDSEPAARRLSFSSIPTGNASEPLLDVPVGQETEEKPTWLSRLRIPGLTLPRVWLLSHLLFAACMFSTFFIYSHQAGSAFVGLVGVSWAVALWAPFALISAEVARIDPSRRNRRRAAQTTYTEHADEAQDEGPGELDSVGGSDIENGHPKDYRDNGDVAQAGIILGLHNMAVSLPQILSSLVCSAIFKASQKQRGEPWDDSVGWVLRFGGCAALVAAWLTRRVSDGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>W6QGG4</accession>
    <name>W6QGG4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cyclin C/H/T/L</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S04g000794</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QGG4"/>
    <dbReference type="STRING" id="1365484.W6QGG4"/>
    <dbReference type="OMA" id="KSIMACA"/>
    <dbReference type="OrthoDB" id="340962at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20524">
        <property type="entry name" value="CYCLIN_CCNH_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20525">
        <property type="entry name" value="CYCLIN_CCNH_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000095">
        <property type="entry name" value="Cyclin Ccl1, putative (AFU_orthologue AFUA_5G07030)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043198">
        <property type="entry name" value="Cyclin/Ssn8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031658">
        <property type="entry name" value="Cyclin_C_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10026">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16899">
        <property type="entry name" value="Cyclin_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0195">Cyclin</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin C-terminal" evidence="3">
        <location>
            <begin position="185"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="40"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="368"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="40"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="50"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="372"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM35913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="423" mass="47297" checksum="F09A282E9EE8FAA4" modified="2014-04-16" version="1">MIEDDIYRASSQYRLWSYTEPSLQFLRATTNAVASERVRAALHRSRETHQSTASSAAGTPLPESNTDTKNKDVECLTPEEELVLVRYYCEKTLELGETYKPPIPTMVRATAIQYLRRFYLTNSPMTYHPKSIMACALFVATKTDNYYISLRQFADGIPGDTKTEDVIAPEFLLMQGLRFTFDVRHPFRGLEGGVMELQAIAEGQGQPAPHLPYETAEDLQQGLLSIAPPPVPSSSMSDRIARAHGTTRELLKSAAQMTDAYFLYTPSQIWFSAFLLADRPLAEFLLDVKLGGPVTATIPAPETDENGLVNPLYEIRFKLHHVLTECSALLQSYTPLSSDPAQMKSLKRIAKKLYHCQNPEKVNLAATKRESTQPSSAVQSDTGIVNSESETERLAKKRKLEQGQAVRQDDDVFGPELVTQRTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W6QH39</accession>
    <name>W6QH39_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S04</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S04g001029</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM36148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QH39"/>
    <dbReference type="STRING" id="1365484.W6QH39"/>
    <dbReference type="OrthoDB" id="4358478at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM36148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="252" mass="28198" checksum="4E7224ADC7D6203B" modified="2014-04-16" version="1">MPLPNGPGFYNSSGPRILSMIWKPQMTDGQGGSFATARRLQEQTMTVGGVRDRDIIQNTAVRSRSAMPHSTHNPEVEYEAISNAAAIILLQTLSHLVKTNLEWIFNRVHFSCKFTSMMYNVYTDGALRSKTTSKIFGILEVKKRMRTVNPAAIFAQEACQVAGWLMESSAEMAVFNNHYMLVSQDRHQFFLTFAPFNENYESYLHNGTDTDVFLVMHTVGPFSTSDARQMAQFGRIFVAATLVAKSAAANIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W6QH67</accession>
    <name>W6QH67_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S03</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S03g000268</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QH67"/>
    <dbReference type="STRING" id="1365484.W6QH67"/>
    <dbReference type="OMA" id="MTHQTID"/>
    <dbReference type="OrthoDB" id="412788at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM33544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="158" mass="17760" checksum="0E9ED7CB18609526" modified="2014-04-16" version="1">MIMPMDESFFDSSSQPVLSQAGQIVPATAALFIQIPTHNGCLQTNMTHQTIDGIPGEEIRGQEDQFQLERNGFTIQHGSPVQRFSRVEEVTKYLRLTERVSISVPVGWKFFVTIREPHPVYPISDGNEHDQPATVAHVDTSREGTIDEIRGQMGKRQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W6QHQ4</accession>
    <name>W6QHQ4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Mitochondrial metalloendopeptidase OMA1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">oma1</name>
        <name evidence="9" type="ORF">PROQFM164_S04g000407</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase M48 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QHQ4"/>
    <dbReference type="STRING" id="1365484.W6QHQ4"/>
    <dbReference type="OMA" id="ACFDFRY"/>
    <dbReference type="OrthoDB" id="7464992at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034982">
        <property type="term" value="P:mitochondrial protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07331">
        <property type="entry name" value="M48C_Oma1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2010.10">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051156">
        <property type="entry name" value="Mito/Outer_Membr_Metalloprot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22726">
        <property type="entry name" value="METALLOENDOPEPTIDASE OMA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22726:SF1">
        <property type="entry name" value="METALLOENDOPEPTIDASE OMA1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 6" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M48" evidence="8">
        <location>
            <begin position="180"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="62"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="62"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM35526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="388" mass="43727" checksum="2924AEBF1EF86B21" modified="2014-04-16" version="1">MLRQSMARAFRSACAYPFLSPKPSTKLKAASLAAQTSRSYNTPGPQLSICWAPSLLRQPRPRSQLSFPTPCPSNRRTFSSSHKSPYQQRRNQYNRFRGSARQPLVFRLVQNAKPHHFVAIGVGISGLYLYNTEIVEMTGRRRFNCVSRHQELNMGEESYREVLSSERGKILPHNHPLTRMVDGVLQRLIPQVNIEGADWKVHVIKDDGMVNAFVLPGGKVFVYTGILPICKDEDGLAAVLGHEIAHVVAHHPAERVSNSFITLGAVFAISFLFDVSGQFSSFLLNLMYSLPNSRTQEAEADNIGLMMMARACFNPEAAVKLWARMYEQEKQAPPQFMSTHPSSYNRMEAIQGWLDKANIIYEENGCNSIKGYMPGFHTAYNSHVSYLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W6QHR0</accession>
    <name>W6QHR0_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Negative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S03g000458</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="OrthoDB" id="2101473at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007396">
        <property type="entry name" value="TR_PAI2-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35802">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35802:SF1">
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    </dbReference>
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        <property type="entry name" value="FMN_bind_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010372">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM33734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="261" mass="28744" checksum="70BF212837EE4CAA" modified="2014-04-16" version="1">MYLRAVHAEGQLAVLQQFIRDNPLGIITTAIKSPIYSFIQSSHVPFVLDVPPSTEGDDTAPTGILRGHMAKQNPQAKALMEALAEQNAAGNNKFELTDEVLILFNGPHHHYVTPKFYTATKPVSGKVVPTWNYSAVQAYGKISVYCNSKAEETGAFLQKQIQDLSRQSEEGIMGYTGGDKKSAWNVSDAPVNYVELLKKNILGIEIRVERLQGKFKMSQEMGEGDREGVVQGFEELGSDVGRGIADCVRERAAMKDQQKVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W6QHT4</accession>
    <name>W6QHT4_PENRF</name>
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        <submittedName>
            <fullName evidence="1">Protein kinase-like domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S05g000191</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QHT4"/>
    <dbReference type="STRING" id="1365484.W6QHT4"/>
    <dbReference type="OrthoDB" id="5979581at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM36358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="148" mass="17444" checksum="4701733C610CCA5C" modified="2014-04-16" version="1">MRYIWDFDFATLVWDLFEGRHLFYGNDPDGKGYSTWAHLAEVMGVLGPPPLDMLQRGERSHEFFTEDGKHPFLARDFVKAYEDDVAGKWKQDIEIPIGTSLEISEQFLEGRNKEMIMAFMRDMLQWRPEDRKTAKDLLQDPWLNDRIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>W6QIC9</accession>
    <name>W6QIC9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="10">114 kDa U5 small nuclear ribonucleoprotein component homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">cwf10</name>
        <name evidence="10" type="ORF">PROQFM164_S05g000018</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1365484.W6QIC9"/>
    <dbReference type="OMA" id="YIFRPIR"/>
    <dbReference type="OrthoDB" id="364892at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071007">
        <property type="term" value="C:U2-type catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030623">
        <property type="term" value="F:U5 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04098">
        <property type="entry name" value="eEF2_C_snRNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04090">
        <property type="entry name" value="EF2_II_snRNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01683">
        <property type="entry name" value="EF2_IV_snRNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16264">
        <property type="entry name" value="snRNP_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04167">
        <property type="entry name" value="Snu114p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.240:FF:000004">
        <property type="entry name" value="116 kDa U5 small nuclear ribonucleoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000029">
        <property type="entry name" value="116 kDa U5 small nuclear ribonucleoprotein component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000009">
        <property type="entry name" value="116 kDa U5 small nuclear ribonucleoprotein component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1430.10:FF:000001">
        <property type="entry name" value="116 kDa U5 small nuclear ribonucleoprotein component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.870:FF:000002">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001452">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1430.10">
        <property type="entry name" value="Yeast translation eEF2 (G' domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031950">
        <property type="entry name" value="EFTUD2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044121">
        <property type="entry name" value="Snu114_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035655">
        <property type="entry name" value="U5-116kDa_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="116 KDA U5 SMALL NUCLEAR RIBONUCLEOPROTEIN COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908">
        <property type="entry name" value="TRANSLATION ELONGATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
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        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Tr-type G" evidence="9">
        <location>
            <begin position="130"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDM36185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="983" mass="110060" checksum="3B94408F797764D7" modified="2014-04-16" version="1">MDDLYDEFGNYIGDAESDEEHHEDVQPQAFKFDEAFDDEEEEEINDLQLMEVDEGPSNAVILHEDKQYYPSAQQVYGEDVETMVQEEDAQPLSEPIIAPVQQKKFAIAETELPPVYFSREFMSDLLSFPSQIRNVAIVGHLHHGKTAFMDMLVKQTHDLTERLDKRTGRKREEQLRYTDVHFLERERGLSIKSAPMSLVLPSTKGKSHLLNLLDTPGHVNFVDEVAASIRLADGAVLVVDVVEGVQANTEQIIKHAVLEGLPLTLVVNKMDRLILELKLPPNDAYFKLKHVIEEVNTIIENVLPGQGERLRLSPEKGNVGFASSSMNWCFTLQSFARMYADSYPSLDSTEFAARLWGDIFYNPQSRKFTRKGVEENAKRSFVKFVLEPIYKLYSHTLSESPEDLKQTLASVGVNLKPSQLKIDAKELLSLVCENFFGPATGFVDMVVQHVPSPVEGAQRFLERYYTGPVDTKIGASMLACDQNGPLVIHVTKLFSSTDAASFYSFGRIMSGTARPGQQVRVLGEGYTPEDEEDMVVATISDTWIAETRYNILTNGVPAGNWVLLGGVDNSIVKTATLVPLKLEDDEDVYIFRPIRHMTESVFKVAVEPVNPSELPKMLDGLRKINKSYPLISTKVEESGEHVVLGTGELYMDCVLHDLRKLYSEMEIKVSDPVTRFCETVVETSAIMCYSITPNKKNKITMIAEPLDDGIAEDIESGKVSIKDPIRKVARYFEENYDWDKLAARSIWAFGPDEMGPNILQDDTLPSQVDKKLLGTVRDSITQGFSWGTREGPLCEEPIRNTKFRLTDVSLADQAIYRGGGQIIPTARRAVYSSFLMASPRLMEPIYSVTMTGPADSVASVYTVLSRRRGHVLSDGPIAGTPLYSVRGLIPVIDSFGFETDLRIHTQGQAMVNLVFDKWSVVPGDPLDRDIKLKPLEMAPAMATARDFVLKTRRRKGLAEDVTVSKFLEPELWKGLKESGVLDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W6QID0</accession>
    <name>W6QID0_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Zinc finger, C2H2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S04g000627</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QID0"/>
    <dbReference type="OMA" id="WASHWAD"/>
    <dbReference type="OrthoDB" id="10541874at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="137"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="111"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="168"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM35746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="185" mass="20507" checksum="F8501CCD637D6F30" modified="2014-04-16" version="1">MEIEHLEPGMMGFFQPPILPTVYSQPGTVGDKLDVASSFTRDAALDFDAYNAAALHQLPFQPAHEAFNQCSLINGCSINTSSQAQWNDQILQSVPAYEIEHVPSASKIAQSPFRPLRPKPTQQQTQMPRLAASKKPLHCTKCSKTYNSPGGLRRHDVKGHNAERRTGGRPSTSSRRLSWIIVKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W6QII8</accession>
    <name>W6QII8_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Beta-lactamase-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g003209</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QII8"/>
    <dbReference type="STRING" id="1365484.W6QII8"/>
    <dbReference type="OMA" id="DKACEDQ"/>
    <dbReference type="OrthoDB" id="428260at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050789">
        <property type="entry name" value="Diverse_Enzym_Activities"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43283:SF3">
        <property type="entry name" value="BETA-LACTAMASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G07500)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43283">
        <property type="entry name" value="BETA-LACTAMASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase-related" evidence="1">
        <location>
            <begin position="21"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM29397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="414" mass="45492" checksum="07E869586EA765E2" modified="2014-04-16" version="1">MSLNAQVQSHLRDIVDKACEDQKSGIPGTTVVVVGKDGNELFAHSAGKRGAGSEDPMTLDTIFWIASCTKVVVGLACMQLVEQGILKLDDAEQTEGLCPELKSLKVLLPDGSFEEKKNGITLRMLLSHTAGFGYTFFNERLRQWSYPIGADEFSGRIEDMKMPLLFQPGEGWQYGVGIDWAGIALERATGLTLNEYLQKNIFLPLGIKNMSMIPSHDMRQKLAYMNQRNPDGTLRPRDHPLRAPLVVDLENKAEVARVFNSGGAGIFAKPQDYCKVLAVLLNDGTCPKTGSKLLRKETVDEMFSNQIPQFPNYSRQSIPDAKPDLTNPVPELYPVAGNPPQGWGLTFMLSNGGPTGRSTSTGHWAGLPNLWWWADREKGVAGIVCTQILPFVDLNVLGLWGTVEAEIYKALGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W6QIL7</accession>
    <name>W6QIL7_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S01g003249</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QIL7"/>
    <dbReference type="STRING" id="1365484.W6QIL7"/>
    <dbReference type="OMA" id="PSAQWAH"/>
    <dbReference type="OrthoDB" id="4538483at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM29437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="649" mass="70115" checksum="DC885E2F9C91FE3B" modified="2014-04-16" version="1">MSVPSTFDAVKSHLAQVQENPSTALDIPLIDKLKLQLVENTDPVVPATLLSQISALLPILQEDPTPITTLGIRATAYFTFTNLQSIDPPINLVAGFKAPSPPINLLALSLLAKAGQKYSEAAIVAGDSDLVASLVELWLSTSSGEVAQAALDTLWALLEVDVANHLETGEYEHTGNASHAGQGLLWRRVFTDKDVYGLLFGLCSLQSDAPGDLSKGERTIAQGRLMTLLVKAGRLRWDIISTTQVPEIEAKYQSSSLLHFATCHMVQVSDVLMYMTLLNFFRELLEIDGPGLVARRSVQSTSTFSSPALDFLVEHQLHSKVLSYYLDESKLDSVDLIYLSGPIMAYVARYAEMYPNHLLQNPSTLLDAIISRINRSLAIASAQWAHGEVPTGHLAILASLPRVLLVEAGIYGANPVLAIPTNPPNSEALGVLAKIFHGPQRTGISDSMNLNTSGSTPTDWDREAAAARILYFLYVNQHPTFWDNVVGAADVLVMKDVALSAISFMGAITTANWKLSPSAPANTDSSRFQLPSEKDLDQLSPATNGFFPTSGAWAVLTPPALTTLLPYLFKPPRSYADFVGGGAADSQNVVWKVATAKHDVIVALHNRLQETDGQVEGFEDIMRTLQQRVNEGPRGPVQFGGAEVMAAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W6QJH0</accession>
    <name>W6QJH0_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S01g003540</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QJH0"/>
    <dbReference type="OrthoDB" id="4355543at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM29727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="115" mass="13341" checksum="50F351C318EC46A2" modified="2014-04-16" version="1">MDYIVQEVHPSQDGWDDEFRNEIHAYDRLKMLRGTLIPTLFGQGSFNVCPALILSEIDGITLRQRSKSDVHEKTLETQLEKALKTLYEHGAEFWDQNLGNFLFCSNGEVKIWYCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W6QKQ3</accession>
    <name>W6QKQ3_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S06g000370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792020">
        <property type="protein sequence ID" value="CDM37408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QKQ3"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM37408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="54" mass="5710" checksum="3D61DADD834CB8FC" modified="2014-04-16" version="1">MSSRFEKRFLTRRRIASLRVDADAISLLVETMGVGGGGGDPRGPGEGRYRGSGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W6QL99</accession>
    <name>W6QL99_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Major facilitator superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PROQFM164_S05g000579</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QL99"/>
    <dbReference type="STRING" id="1365484.W6QL99"/>
    <dbReference type="OMA" id="ICFACTI"/>
    <dbReference type="OrthoDB" id="3639251at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000386">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000065">
        <property type="entry name" value="Putative MFS pantothenate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF15">
        <property type="entry name" value="TRANSPORTER SEO1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="149"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="184"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="219"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="287"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="325"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="354"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="382"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="414"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="448"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="58"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="18"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDM36746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="478" mass="53384" checksum="C9AEC3ABC4A3F5B1" modified="2014-04-16" version="1">MSSLPIEKAPQTMGAEENPTKTEHPSGSEPARQKWYEWFAPTDTPAERRLILKLDGLIIVFVFLAYWAKVLDSSATSTAYVSGMKEDLKLYGNQLNYLQTVYMVGFITMQIPLTLLMTRCPVNYFLPAADLFWGVFTLAQYKASNVTQLYALRFFVGALGGFFFPAVQWYLGSWYKRSELSRRGAIFFIASQVGSMSSGYIQAGAYARLDGRYGIEGWRWLYIICFACTIPIAFLGLCLLPSTPDKCDSRFLSADEVRLAQERMASENREARQPFTKSRVLQILKGWRLWVLVGFAFFFSQADGVSSNSGLPIWLKEEGYSVESINTITTVSPAVTIVASVICGVLSDVYDAKASLIAATALLNIFACIVLAIWNVPIGLKFFAFFLSGTADGIAAIIYAWANEICAHSAEERAIVISAMNTIGNTFGAWIPLFVWKTVDAPRYLIGYNWTIALDVCMLAMLAVLYQFWAREKKRSHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W6QLU1</accession>
    <name>W6QLU1_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S07g000116</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792021">
        <property type="protein sequence ID" value="CDM37768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QLU1"/>
    <dbReference type="OMA" id="HTMFSSI"/>
    <dbReference type="OrthoDB" id="4685598at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053181">
        <property type="entry name" value="EcdB-like_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47785">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM37768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="293" mass="32916" checksum="FC29560AACF43C5C" modified="2014-04-16" version="1">MASTSIQYLNSRSQASADNHDLKSSIILLSWAAFDTECDLIAEHHLPRSGIEHVIDLTPFPTFANNDAKETHVFLAELSIRRLLNRVHHTMYGSDWTRRSLGLQPVSSDSPSYDFQSLSAILNVSQELARQLDNWFDLLPRTIKPDMNDPSRCTGLQLNMLHRFHSAKDIITRPFLLCAIDSSPENDVPPMVLKQCESSIANCRTYLDASTRRLVGPSFCAEIIIHTMFSSILLLTLGSVCPALAHLVPDIDTLQKNTIETIERFAVEGSLMQEIHGIIVLLHSKTRVLRRAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W6QM89</accession>
    <name>W6QM89_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AIG1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S06g000512</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792020">
        <property type="protein sequence ID" value="CDM37550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QM89"/>
    <dbReference type="STRING" id="1365484.W6QM89"/>
    <dbReference type="OMA" id="KGCHAMI"/>
    <dbReference type="OrthoDB" id="8954335at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00882">
        <property type="entry name" value="Ras_like_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G" evidence="2">
        <location>
            <begin position="41"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="335"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="335"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="400"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM37550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="489" mass="56326" checksum="39EC4D3ACA6C7162" modified="2014-04-16" version="1">MSVRSSFTRQSGNRSVHGNESPLSTRSFRGGHEPRPTDVFIAVMGVTGSGKSSFISLCSGKSVQIGHTLDACTSKVDVYAYRESSDRTVYLIDTPGFDDTSKNDTEILSEIAIWLGDSYRSKILLHGIIYLHRITDVRMQGSARRNIQTFRNLCGEDALRKVILVTTMWDKVQSSEGDMREKQLKDTKDFWGWMLSKGSTCHRHDNTKTTARSIVQRLTKHKSPIITDIQKQLVDQNLQLDQTAAGKGIQSETLKERAKWMKEQKKFEEEIREAMRQKDREKEEIMREERDMSAAMIRKANQDMEAMRFNMEELIAQREEREALLEERLEKRMERQMRKKQAAHDKEIKRIQREKEAEMRISREQEKQAQRDRKKVEEKNKAQQQRKAEQERKAKVAEANRQSQNSSSKVQGWSPFSVTMGDYSCALSGPRCYQAGGWPKLQVGSEWIGAVSYGTSGTWIARYGGGTWRKQFLKSATIYLAKRCLRVLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W6QMG7</accession>
    <name>W6QMG7_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AAA+ ATPase domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S06g000582</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792020">
        <property type="protein sequence ID" value="CDM37620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QMG7"/>
    <dbReference type="STRING" id="1365484.W6QMG7"/>
    <dbReference type="OMA" id="YLGTEWV"/>
    <dbReference type="OrthoDB" id="6512918at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001332">
        <property type="entry name" value="Similar to ABC transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43158">
        <property type="entry name" value="SKFA PEPTIDE EXPORT ATP-BINDING PROTEIN SKFE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43158:SF2">
        <property type="entry name" value="SKFA PEPTIDE EXPORT ATP-BINDING PROTEIN SKFE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="3">
        <location>
            <begin position="11"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM37620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="280" mass="31013" checksum="F0D8AC9341A48C35" modified="2014-04-16" version="1">MADTNSTPPSIEVQNLSYKFQDGSSGLENVSMSLPAGSRTLLIGANGAGKTTLLRLLSGKRLAPNNTIAIGGKDPFKDSLDGVTYLGVEWVLNSIVRTDIDVPTLLASVGGNAYPERRDELIDILDVDLRWRMHAVSDGERRRVQLAMGLLRPWQVLLLDEITVDLDLLSRSNFLAFLKRETETRACTIVYATHILDNLAQWPTHLAHMHLGKVKALGSVESFHEEVPAWTSENSRLGELVLKWLKEDMQARGPRNDRGNQAKTYQSLEGIGGYGLEKHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W6QMJ5</accession>
    <name>W6QMJ5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PROQFM164_S09g000019</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792023">
        <property type="protein sequence ID" value="CDM38103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QMJ5"/>
    <dbReference type="STRING" id="1365484.W6QMJ5"/>
    <dbReference type="OMA" id="HPGKTHI"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF32">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="104"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="134"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="163"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="196"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="303"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="331"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="395"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="427"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="37"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM38103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="468" mass="51964" checksum="C9B90F7E9652F0F3" modified="2014-04-16" version="1">MSKSPECKSRHAMDIDANEGCDNRYSYHNRRTADFRVLPLLVLGFASYQLDRTNIASALTGNFASFISVNQNIINFGNQLMFLGVIILEIPSNIILHKIGPRQWISGQVCIFGIIACLQIFVRNKLGFLLTRTFLGLAEAGYIPGAMYTLSTWYTKEELTKRIAIFFFGMFGGTAISPLLGAAFLKLDGKGGLFGWQWIFLVEGLFSVAVSFVLFFFLPEHKKVPVSTDEVNISESGGLRLTEKPLAHPGKTHISLSLVWKTLTSFQKWPHFIATGCVFATWSPLTTYTPSIFMELGFPRVRANALCAIGSLLTLPVILVFAWISDKSNKRGLTVIVAIFVYLIALVILRIAVHHVDKWGKFGLWTTVNALAVGYHPIHNSWIQINCKSSEERNISVAMFVMSATAGLMAGTQIFRADESAIFYPRGVSIMIGLLVLGLILVSLQISIFWILNRRIKAKTGNGVLNIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W6QMV3</accession>
    <name>W6QMV3_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Zinc finger C2H2-type/integrase DNA-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PROQFM164_S06g000212</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792020">
        <property type="protein sequence ID" value="CDM37251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QMV3"/>
    <dbReference type="STRING" id="1365484.W6QMV3"/>
    <dbReference type="OrthoDB" id="654211at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000100">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="97"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM37251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="124" mass="13706" checksum="7CD5049235962FDE" modified="2014-04-16" version="1">MPKCSLEMTVGAYANPSTFSSQAVNSALSDTWSTNNMLTRDAQDLSAESTEPLGSRNIKRNNEFKCGWKNCTSSGGFASKSSLMRHIESLHVSPRGFACPHCRKSFNRKDQLQAHRSIVHVGRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W6QN36</accession>
    <name>W6QN36_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Genomic scaffold, ProqFM164S04</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PROQFM164_S04g000450</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endomembrane system</location>
            <topology evidence="8">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QN36"/>
    <dbReference type="STRING" id="1365484.W6QN36"/>
    <dbReference type="OMA" id="MNRMLIM"/>
    <dbReference type="OrthoDB" id="261831at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15853">
        <property type="entry name" value="SNARE_Bet1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000057">
        <property type="entry name" value="SNARE complex subunit (Bet1), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039899">
        <property type="entry name" value="BET1_SNARE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12791">
        <property type="entry name" value="GOLGI SNARE BET1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="44"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDM35569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="168" mass="18499" checksum="6BE2A8AC8188743F" modified="2014-04-16" version="1">MASRFPRQRDPRASSSLFDQYGGDSRQASRSPAQQPGGYGYGGYPSPALNGYASSGAAGGGYQSASPDKKGHYSDAVLSSLESQNDAEVEGISAKVKMLKDITLAIGDEIRDTTHITDLNDSFDNTRVRLRGNMNRMLRMAESTGIGWRVWLGFFFAVFLLFFYVWIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>W6QN39</accession>
    <name>W6QN39_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Sm protein F</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PROQFM164_S02g001217</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM164</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="9">Component of the heptameric LSM1-LSM7 complex, which consists of LSM1, LSM2, LSM3, LSM4, LSM5, LSM6 and LSM7. Component of the heptameric LSM2-LSM8 complex, which consists of LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8. The LSm subunits form a seven-membered ring structure with a doughnut shape.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QN39"/>
    <dbReference type="STRING" id="1365484.W6QN39"/>
    <dbReference type="OMA" id="GYMNVQL"/>
    <dbReference type="OrthoDB" id="10248838at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034715">
        <property type="term" value="C:pICln-Sm protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01722">
        <property type="entry name" value="Sm_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000055">
        <property type="entry name" value="Probable small nuclear ribonucleoprotein F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016487">
        <property type="entry name" value="Lsm6/sSmF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034100">
        <property type="entry name" value="Sm_F"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11021:SF0">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11021">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN F SNRNP-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006609">
        <property type="entry name" value="snRNP_SmF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 11" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11 13" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 11" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="12">
        <location>
            <begin position="7"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR006609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDM31067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="88" mass="10024" checksum="7DC435DFD1387A36" modified="2014-04-16" version="1">MSFQPLNPRPFLQARVGTEVLIRLKWGQTEYKGTLESIDSYMNVLLRDTQEFIDGKPTGALGLVLIRCNNILWMGSANAIEMTDMEFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W6QP57</accession>
    <name>W6QP57_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Extracellular membrane protein, CFEM domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">PROQFM164_S02g001522</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RBT5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QP57"/>
    <dbReference type="STRING" id="1365484.W6QP57"/>
    <dbReference type="OMA" id="HCQKPEL"/>
    <dbReference type="OrthoDB" id="3767534at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051735">
        <property type="entry name" value="CFEM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008427">
        <property type="entry name" value="Extracellular_membr_CFEM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37928">
        <property type="entry name" value="CFEM DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G14090)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37928:SF2">
        <property type="entry name" value="GPI ANCHORED CFEM DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G10580)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05730">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00747">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52012">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12 15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="6 15" id="KW-0349">Heme</keyword>
    <keyword evidence="10 15" id="KW-0408">Iron</keyword>
    <keyword evidence="14" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="9 17" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004880371" evidence="17">
        <location>
            <begin position="19"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="CFEM" evidence="18">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="94"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="15">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="50"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS52012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CDM31372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="233" mass="22541" checksum="4A1552DD08CD9983" modified="2014-04-16" version="1">MKFSTTLIAFVAAGLASAQLPDVPACSLSCFISALQSDGCSELLDFKCHCQKTELVTSITPCVQKACDHSDQVSVSNAVVGQCSSAGHPISVPPVETSASSTVSASTSSSAPAETTATPTASASETSSAVETSSAVETSSSAVETSSSAVETSSSAVETSSAVETETSSTGTTATGSSPVGSSSGVATSTPLVTKTGSSSGATPSPTYTGAGANVKGNMAGVAVLAAAAAYVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W6QPA3</accession>
    <name>W6QPA3_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S04</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S04g000815</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QPA3"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM35934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="45" mass="4962" checksum="3D9B206CA567DE5B" modified="2014-04-16" version="1">MRQFVSPATEREEHARWAALSCRQDENDTTTPSIQGGQLASIATT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W6QQB1</accession>
    <name>W6QQB1_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S09g000087</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792023">
        <property type="protein sequence ID" value="CDM38171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QQB1"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM38171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="72" mass="8557" checksum="3268D6EC6A892E16" modified="2014-04-16" version="1">MSDYCHSFFYFHGCYDTLLRYKQSPLQFYIPRGLDVFVRGEFLLQSVVVAGYVELPYHYIIIYGVRQCSTEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>W6QQW9</accession>
    <name>W6QQW9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="8">EF-hand-like domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PROQFM164_S02g002093</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QQW9"/>
    <dbReference type="STRING" id="1365484.W6QQW9"/>
    <dbReference type="OMA" id="YNKSYNP"/>
    <dbReference type="OrthoDB" id="186625at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048306">
        <property type="term" value="F:calcium-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd16180">
        <property type="entry name" value="EFh_PEF_Group_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051426">
        <property type="entry name" value="Peflin/Sorcin_CaBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46212:SF3">
        <property type="entry name" value="GH27120P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46212">
        <property type="entry name" value="PEFLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13202">
        <property type="entry name" value="EF-hand_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13405">
        <property type="entry name" value="EF-hand_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="198"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="228"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="24"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="53"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="106"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="118"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM31942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="341" mass="37826" checksum="B20941AE4C45A9A5" modified="2014-04-16" version="1">MAYNKSYNPDALPAHAEPEEAAQMLSNMSVSGHTPSHTQKPLPSRPSPQGTHSGVPPRVPVSSSSAPQHAYASAPPRLDSQPYHSHSHSNSYSGRPSATNAPPPSQHFSQSQSRPHPLHPSPPPQNYGFGPPPVHPQRNRPPPSSRPPQSPAPPPLTAPSDDPQQLFPLFRAANASHSGTLTEGELGSALVNGDYTSFHPRTVRLMIRMFDRDGSGTINFDEFVSLWRYLAAWRELFDRFDEDRSGRISQREFENALVAFGYRLSGKFISVIFGVFEAKAKQMSNAPKDYRSTGMSFDLFVQACISLKRMTDVFKRYDDDRDGYITLSFEEALTEILLLQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W6QSM1</accession>
    <name>W6QSM1_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RNA 3'-terminal phosphate cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PROQFM164_S02g002638</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RNA 3'-terminal cyclase family. Type 2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QSM1"/>
    <dbReference type="STRING" id="1365484.W6QSM1"/>
    <dbReference type="OMA" id="YTDQNKG"/>
    <dbReference type="OrthoDB" id="1911237at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000479">
        <property type="term" value="P:endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00875">
        <property type="entry name" value="RNA_Cyclase_Class_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.20:FF:000004">
        <property type="entry name" value="18S rRNA biogenesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.20">
        <property type="entry name" value="RNA 3'-terminal phosphate cyclase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.20">
        <property type="entry name" value="RNA 3'-terminal phosphate cyclase, insert domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013791">
        <property type="entry name" value="RNA3'-term_phos_cycl_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023797">
        <property type="entry name" value="RNA3'_phos_cyclase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037136">
        <property type="entry name" value="RNA3'_phos_cyclase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000228">
        <property type="entry name" value="RNA3'_term_phos_cyc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016443">
        <property type="entry name" value="RNA3'_term_phos_cyc_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036553">
        <property type="entry name" value="RPTC_insert"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03400">
        <property type="entry name" value="18S_RNA_Rcl1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11096">
        <property type="entry name" value="RNA 3' TERMINAL PHOSPHATE CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11096:SF1">
        <property type="entry name" value="RNA 3'-TERMINAL PHOSPHATE CYCLASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01137">
        <property type="entry name" value="RTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05189">
        <property type="entry name" value="RTC_insert"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55205">
        <property type="entry name" value="EPT/RTPC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="RNA 3'-terminal phosphate cyclase" evidence="5">
        <location>
            <begin position="10"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="RNA 3'-terminal phosphate cyclase insert" evidence="6">
        <location>
            <begin position="205"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM32487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="402" mass="42218" checksum="16FC68EB4F8F3F75" modified="2014-04-16" version="1">MATSQPPLRFTSHHNLVYRLVLSTLTGRTVHISQIRSSSPTNPGLAPHEISFLRLLDAITNGSQMEISYTGTVLVYKPGLITGSTAGTGASGGMITYELPSNCNRGLSYFLIPLCLLAPFAKAPMKVLFTGPGVITSSTQTGDMSVDSVRTAILPLYKQFGIFNNIELRILRRSNTGPTGRGGGGEVQLVFGHQVRLPKTLHLMNAGRIKRIRGVVYSVGVSGSNNARMIETARGILNPLSPDTYIFSDVASAPLVPAPDKTNPQAKKKIGLGFGLSLVAESSTGCLFSADVASPPSGGQAPEEVGKQCAFQLLETVAKGGCVAPAAATTMFTLMTMGSEDVGRLQVGRDVIADPNVVQLARDLSKFGAPGWGIRDAPDNGDGDVIVSIVGRGIGNVGRKIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W6QT07</accession>
    <name>W6QT07_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S02g002798</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QT07"/>
    <dbReference type="STRING" id="1365484.W6QT07"/>
    <dbReference type="OrthoDB" id="5244761at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053181">
        <property type="entry name" value="EcdB-like_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47785:SF4">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47785">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM32647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="288" mass="32045" checksum="6685A7C5AFA80C3D" modified="2014-04-16" version="1">MWLSIKRLIHPERYDEDYVMRLEEEHSLISIYGQGEISYTADNSQLPMDCESKGAQPGVNGAGQHVNIDIDEFGNLDLDATTARRYYDSYFKHMFKLYPFLMEGELGIKVDNFIESYYRVNNSPPSSVSSYAQPARNSPPLAKKRQSNENLSVRGELLEPVSNLLRPRVGKNINTALILLYLALGAICEAPAPLPRPVIDKKIDYLNQYIPAPLAPFNSPLPAITIYVTDTNGMLPSVNSGLAAVQTSLSNPLYSVPAQPIGQAFLNSSSNNHIEGLLRRDITNTQDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W6QT51</accession>
    <name>W6QT51_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Zinc finger C2H2-type/integrase DNA-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PROQFM164_S02g002853</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the sal C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QT51"/>
    <dbReference type="STRING" id="1365484.W6QT51"/>
    <dbReference type="OMA" id="ANSICCY"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000478">
        <property type="entry name" value="Zinc finger protein 133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051565">
        <property type="entry name" value="Sal_C2H2-zinc-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23233:SF84">
        <property type="entry name" value="FI23031P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23233">
        <property type="entry name" value="SAL-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="221"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDM32702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="279" mass="31461" checksum="7B84316A3E7FFA17" modified="2014-04-16" version="1">MDLHELLNDASSPTAYIRPNKQHPRQSSVQTNMLPSFSTLAKSVDYATNNDRDRSVQAASCRRDAAHVPICHPFQPHHPDPSFSQKMRFPTDHQSANSICCYPHYSIPNACPGSFGTHVQGSFPSSAPSVNHYSSLIYFPSPPATNSASNYMCTPYTTSFYDPMSHCCSFQPDPIEHIHKAWGHQQLVESPLLAQIVSQPGYHKRVFPRGIRAMRKNNNQYECRSCDRLFSRPSALNIHFRSHTGEKPFHCPNIGCDRAFSVLSNMKRHTSDCRKTAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W6QTV5</accession>
    <name>W6QTV5_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Calcineurin-like phosphoesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S06g000541</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792020">
        <property type="protein sequence ID" value="CDM37579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QTV5"/>
    <dbReference type="OMA" id="CNPRGYI"/>
    <dbReference type="OrthoDB" id="550558at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37844">
        <property type="entry name" value="SER/THR PROTEIN PHOSPHATASE SUPERFAMILY (AFU_ORTHOLOGUE AFUA_1G14840)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37844:SF2">
        <property type="entry name" value="SER_THR PROTEIN PHOSPHATASE SUPERFAMILY (AFU_ORTHOLOGUE AFUA_1G14840)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM37579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="254" mass="29246" checksum="5B21D21B257A3F19" modified="2014-04-16" version="1">MAQFIRKLFSQPSVSIHTLSDLHLEVNQQYTSFDVPVVSKYLLLAGGIGLILGNHEFYGGSFELAFETVRRLEQEPSLNGRLILLHQRRYDIPDSHVTVLGFTFWSNIPENSRDIVHYKIQDFQKIKDWTVDEHNAAHESDLNWLRNEVQSIYNNHKTNPTELSKRSILVATHHAPAMHRTSSPQHAKNPWSAAFATDLLSQPWNGVKNWVFGHTHYSTEFKERGIRVVSNQRSYILPWSNEANGFDSGNVIWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W6QV77</accession>
    <name>W6QV77_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Heat shock protein Hsp70</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PROQFM164_S08g000090</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792022">
        <property type="protein sequence ID" value="CDM38039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QV77"/>
    <dbReference type="STRING" id="1365484.W6QV77"/>
    <dbReference type="OMA" id="SRTPMIQ"/>
    <dbReference type="OrthoDB" id="10262720at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034663">
        <property type="term" value="C:endoplasmic reticulum chaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10230">
        <property type="entry name" value="ASKHA_NBD_HSP70_HYOU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000039">
        <property type="entry name" value="Hsp70 family chaperone Lhs1/Orp150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000004">
        <property type="entry name" value="hypoxia up-regulated protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639">
        <property type="entry name" value="HSC70CB, ISOFORM G-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639:SF3">
        <property type="entry name" value="HYPOXIA UP-REGULATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0346">Stress response</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004880511" evidence="9">
        <location>
            <begin position="36"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="604"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="798"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="857"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="629"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="804"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="863"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="875"/>
            <end position="885"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDM38039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="903" mass="98307" checksum="9DCF6864A7825240" modified="2014-04-16" version="1">MAFLNRRQLSSSPMLSLVVLPFLVFLLSFAGSASAAGSAVLGIDIGTEYFKATLVKPGIPLEIVLTKDSKRKESAAVAFKPTRESDAPFPERFYGGDALALAARYPDDIYINLKTLLGVPFNDGDEEAVKNYRSRFPALKLEAAPDGRGSVALRSNRLGEAQKKDAFLVEEILAMQLKQIKANADTLAGKGSDVRDVVITYPVFYTAEEKRSLELAAELAGFKIQALISDGLAVGLNYATSRTFPSVSDGEKPEYHIVYDMGAGSTTASVLRFQSRKVKDVGKFNKTIQEVHVVGAGWDKSLGGDSLNDLIVNDMVAHLVEDTKLKDKVTPAEIKAHGKTMSRLWKDSEKLRQVLSANTETSTSFEGLYDENINFKYKLTRANFEKMAAEYVARIGTPVEKALAAAGLDLSDIESVVLHGGAIRTPFVQKQLESLAGSSKKIRTNVNADEAAVFGAAFKGAALSPNFRVKDIRTGDAATYPISLKWNSDGKQRNQKLFTATSQVGPEKQVTVKNLEDFEFSFAQHVSQDEEQPILSVQTQNLTASVARLKDNFGCTTANITTKFTIRLSPVDGLPEVMAGTVSCEVESEKKGIVEDVKGFFGLGKKDEQEPLGEDGEPRESITLEPETESSPASSASSKTTTTSTKDAKKDAKATPQVNIEVIPISLKSVTLGTPAPSAAELSRIKGRLLAFDDSDRDRILREEALNELESFIYRSRDLAENEEFINAVKPDQLVVLSERVSKASDWLSDESDNAKTADFQSRLKDLKAIVNPALKRMKESSSRPARVQLLKDMLKNADSTPLPSQPQAPPPPPPRPAHRPQPQPLLMTLSVISMISMKTHTPVLLLPHLLRVPLRPNPQAPSTPSSLPLTSRPSPRPTSPPSPGSKPSSVCKRNFPSLMTQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W6QWH3</accession>
    <name>W6QWH3_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S14g000003</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792028">
        <property type="protein sequence ID" value="CDM38504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QWH3"/>
    <dbReference type="OrthoDB" id="4362204at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM38504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="59" mass="6283" checksum="78DF31BAF2C3DAB0" modified="2014-04-16" version="1">MARSGSCRAPGALLLDPGLIILLSEVAESPHKIPLPDLRTNMSHSTTPGKASYSPRNRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W6QXX7</accession>
    <name>W6QXX7_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S03</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S03g001111</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QXX7"/>
    <dbReference type="STRING" id="1365484.W6QXX7"/>
    <dbReference type="OMA" id="RTKGAPY"/>
    <dbReference type="OrthoDB" id="3045089at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM34387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="1053" mass="119471" checksum="78AB8C47691E0694" modified="2014-04-16" version="1">MPSSLGVIEIPALAKVTWDLYSQCQIIAKDAPAGFQKLATELGSLQGTLRTFVDNVDFKASFLEKMDENCKQTFERSLGACFATLQRLKELLSRLKGFETGDGKGFWQKIKWVTQRTQIEDLRSEITVHTCNLSQYMSSIGKPSLARIEKTIVLATGEDEQIVLSTAASPVRDTDSVVSPMSPGQGIVELPANNEEKCEMDIIEEVRAKMLELGNNRSSVGSSSKVKHTSTSSKSSITESDESPLDDTSPTSWLTLNTSPFVPTRGRINHTRMRSEQLLFGGSIDGGTLDDGIWANNSDQAEEQVVQQTRSYSDDEYGSPHIIEAVTPAMQHLRDVRHREHISRPIRFEPQNKLHRPTAETLKTFKASVNDGLQIIRLATRDWLRVATWWLLKARTTLANCNRHNYVCARGSLSPSMESRSPSHQAYLDLLKASYILYDIVLEEEPSPALLVDEDRKSIVELSEGINEELSQYTSVDIPEPSHLHTQNLDIWEPMQPEETWNGSINLDLGLDNLRWIAVDLEDAGNEQEKVLYRTFVNACIGGKRFRMRTKGAPYMLLLATREGESEPKIVLCNQSGTLCLERDYDLSPLVQLSNAYLTGFPGARVSEPVPFKFDNISVSISFQFDRDLAQFINIPKAYFDAVWQREPFDSTEFTESVIFKTSVDIFEQLNTPTMKPMNPPVMVKSCEVRILERSFREAWRSIRRIVITSSAAEKAPRTMELFMPLSAVQISRGNMSRQVVLQWSDTCQVRSDKTDGNYNPLHSYVYDETAPNIGVGLQFHSHQEAEDFEKAVLEMNFHPNFSWSQPSSSGLIYNVVDTGTEHKQYKAVLVFRTRAPWRYSDLYYIYRDADYIYDHSSFSIHFPRIYCTDYISTHVDQLYHPEGPVTFSHSDKKTSETTIEFGNDPVARSFLSSLSPLYELLYSRRIQSLSTKGNSLFGFQMSTKRSADIQLWRRGTAFQLAARWDESVPDKWLTMAVPSEFIDCSKENTRLTLPRLPYMRGTTLDMMNVMARSSKNPIVKNKEGAMSISFQTSEDRDEFLAVLQGQQLPKFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W6R1Y6</accession>
    <name>W6R1Y6_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Stress-induced protein, KGG, repeat</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S04g000718</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6R1Y6"/>
    <dbReference type="STRING" id="1365484.W6R1Y6"/>
    <dbReference type="OMA" id="EQAEKHQ"/>
    <dbReference type="OrthoDB" id="2137750at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019626">
        <property type="entry name" value="Stress-induced_KGG_rpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10685">
        <property type="entry name" value="KGG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM35837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="147" mass="15397" checksum="800C324F7732504B" modified="2014-04-16" version="1">MMAFTISTRIMSRPLLRLLPSAQSVNVGLWHRCSVATASNHPHHPNPGNFSNRPKQELSEIGHKGGKKGGKATGVGGFHNMDSEKQHAIASKGGHAGGHAGSRAGGRAGARGKAVGNGETELEAEQHGRSHEPSVVAPGFEEWKTTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W6R5Y4</accession>
    <name>W6R5Y4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Basic-leucine zipper domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S06g000183</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792020">
        <property type="protein sequence ID" value="CDM37222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6R5Y4"/>
    <dbReference type="OMA" id="ITRSMYC"/>
    <dbReference type="OrthoDB" id="2245989at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021833">
        <property type="entry name" value="DUF3425"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38116:SF5">
        <property type="entry name" value="BZIP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38116">
        <property type="entry name" value="CHROMOSOME 7, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11905">
        <property type="entry name" value="DUF3425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="2">
        <location>
            <begin position="29"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM37222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="450" mass="49796" checksum="C65D96FD4208A2BF" modified="2014-04-16" version="1">MPFQTREGTLQRDSVGKAKRKPVRRDPEKRRQQNAQAQRKYREKFRERLESLEALAASATPGRATERTPAAGTGPSEAVATISSTTAPTHIAKSLPAYDTWDISTSSPSTATSRECQYFTPQSNDTLSAPSVWDFTTYCPQADTSPSSLSIWDSPTHVSRSDGTPLSPRIWDSTTHISQSDGTPPSLSVWDSTTHVDPSLLICDKQNDALGLYWTTNIDCGCSSPHFQIWTEGPAGPFSCGEVRILRFGSSAPAADPYANNLRIETVCTIAALSTLGIHVGITEETLCAEESLSPFFQSSTESADDMAKANMICTVKRTFKTLKPDLRPSSEQITVKHHPYIDILPFPTLRKGLIAHQEEVDEDDFFHDMLNGLVCWGGAGIGKKDRNNSTGYVSTGTPWDVRSWEAKVWFLKKYWTLLGGEDGELVRQSEWWRSTRGEDTPEISPQLEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W6R6J9</accession>
    <name>W6R6J9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator TACO1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PROQFM164_S06g000409</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TACO1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792020">
        <property type="protein sequence ID" value="CDM37447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6R6J9"/>
    <dbReference type="STRING" id="1365484.W6R6J9"/>
    <dbReference type="OMA" id="NFDIPDE"/>
    <dbReference type="OrthoDB" id="2017544at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.200:FF:000002">
        <property type="entry name" value="Probable transcriptional regulatory protein CLM62_37755"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.980">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017856">
        <property type="entry name" value="Integrase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048300">
        <property type="entry name" value="TACO1_YebC-like_2nd/3rd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049083">
        <property type="entry name" value="TACO1_YebC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002876">
        <property type="entry name" value="Transcrip_reg_TACO1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026564">
        <property type="entry name" value="Transcrip_reg_TACO1-like_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029072">
        <property type="entry name" value="YebC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12532">
        <property type="entry name" value="TRANSLATIONAL ACTIVATOR OF CYTOCHROME C OXIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12532:SF0">
        <property type="entry name" value="TRANSLATIONAL ACTIVATOR OF CYTOCHROME C OXIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20772">
        <property type="entry name" value="TACO1_YebC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01709">
        <property type="entry name" value="Transcrip_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75625">
        <property type="entry name" value="YebC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TACO1/YebC-like N-terminal" evidence="4">
        <location>
            <begin position="36"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="TACO1/YebC-like second and third" evidence="3">
        <location>
            <begin position="115"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF20772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDM37447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="276" mass="30629" checksum="9E72D964BEF38058" modified="2014-04-16" version="1">MALRLSRLLQQSRWVDSACHECRYFSTTSAILSGHNKWSTIKHDKARNDKAKSRERQIVGKEIANATQMWGPDTKYNPRLALALSNAKRASIPKIIIEAAIARGQGLSVSGQALESLTIEAMLPGSVAAVVECQTDQKARVLQDIRYMIKDNGGIVTPTTFLFERKGRVVMEKKDGANVDDYLDQAIEAGAADITTDDKGRLVILTDPSETKTVGETFAKLSGLSIDELEIFWDPNRDSMVVVKDEEQAKDLEDLLSALREDPSVQDIYLNSIEKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W6R7B0</accession>
    <name>W6R7B0_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S07g000080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">FM164</strain>
        </source>
    </reference>
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        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
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        <location>
            <begin position="168"/>
            <end position="202"/>
        </location>
    </feature>
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        <location>
            <begin position="231"/>
            <end position="250"/>
        </location>
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        <location>
            <begin position="263"/>
            <end position="358"/>
        </location>
    </feature>
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        <location>
            <begin position="370"/>
            <end position="461"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
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        <location>
            <begin position="31"/>
            <end position="73"/>
        </location>
    </feature>
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        <location>
            <begin position="76"/>
            <end position="87"/>
        </location>
    </feature>
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            <begin position="174"/>
            <end position="183"/>
        </location>
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            <end position="202"/>
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    </feature>
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        <location>
            <begin position="263"/>
            <end position="289"/>
        </location>
    </feature>
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            <begin position="297"/>
            <end position="339"/>
        </location>
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            <end position="449"/>
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    </feature>
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        </source>
    </evidence>
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            <dbReference type="EMBL" id="CDM37732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="461" mass="48451" checksum="CDC227B07B6226DD" modified="2014-04-16" version="1">MGKKSGKKNKKGSKPVAAVESAKDVVEPEQTEGQTATEQTAPETATQPTETVAEPSKAPEATPVTEAATEIPAVAETKDLETKEAVKAEQAPATEGTVEETVEKVQASKAGQLGELDDGATAGTVLPETITREPASLDVLTGAPATLVERPKTSDSNAPAVAAPVPIAAPAETDAAHTKRPYEKPIFTNEDNLKPHKMPKTDEEAIQASVAEDKKTIETLAGVGPATAAALTTPEPEPVQAEAPKAVVEQKETPVVVEAPKVEEKKVEAPKVAEEKKVEAPKAVVEQKETPVVVEAPKVEEKKVEAPKVEEKKAEAPKKVEEKKVEEKKAEEKKAEEKIPVSTHKTTPAQAGAPSSPVAVAAANAAILASKGDKAAAPAATPVVSKEAEPKKPEAALKRGDEAQPEEALPKAEEPKPETKTEAVKEEAAKAQQDTHKTSESGSQAEKKKGGFMSWLKRKFK</sequence>
</entry>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="112"/>
            <end position="288"/>
        </location>
    </feature>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
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            <dbReference type="EMBL" id="CDM37822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
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        </source>
    </evidence>
    <sequence length="298" mass="33803" checksum="2C3BFCB0D287950C" modified="2014-04-16" version="1">MHQLFRAVSTARLTASYSTRPIRDLRTSNLVPLIEIPKPALASDASHLRAVYDTLEAKGVLQVHLGFSDENSTYLQSLISNLHKNHNHGLPITHSAERGWFWDVRPSPASFQSHGHQARSETMFRFEWHTDCSYEEQPPRFFALQVLQPDRRGGGTLSVLNVDRLLTLLSPFAQKWLSSHNYKITVPPEFIKTEGKQHIVANLLAVNPDGKSGSQLRFREDITVPLTPNATKALDELKEILYGGGARDETLHLTPQCLLQGSIILMDNRRWLHSRNEVKDPNRHLRRVRWDAAPFGSS</sequence>
</entry>
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    <accession>W6R7Q5</accession>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
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                <person name="Conseiller E."/>
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                <person name="Sallet E."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM164</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
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        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="16"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CDM37877.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="532" mass="59074" checksum="F840242C4E9AF7EE" modified="2014-04-16" version="1">MQHSQLAPLPNDVPFRIVSKTIGQGAYACIKKACPLDSDNPVFAVKYIHKDYAARHGKISARQLQLEVTVHRHVSGHGNIISFYQTGEDEVWRWIAMELAEGGDLFDKIEADEGVGEDVAHVYFSQLISAVSFMHSKGVGHRDIKPENMLLTGDGNLKIADFGLAALFEYKGTRKLSTTFCGSPPYIAPEVISSSSRGQNKGAGYHPDLADIWSCGIVLFVLLAGNTPWDSPTDDSFEYHEYVATKSRTTDELWQKLPPATLSLLRGMLTVNPRKRFSLEDVRRHPWYTRANKYLSTDGKLRDTINLATSMFESLHIDFSQDPLSRSGKGSSRSFDPMDVDDCGATSGFSSTQPEMLGGGMLMDWDSPQNGDVFSSTQPFGKKFASQDAALAGHLEDEPSMSQFSQQPSVPMSRTQNAQRFQDIIPSRSMTRFYSAWELKLLVPLICEAFHRLGVPVPIVPAVGSGDTSAMIRVIAKDGRMCPLQGKVLIECVSEGLFEAEFVKIKGDPLEWRRFFKKVVILCKDAVFRPDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W6R834</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    <organism evidence="2 3">
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792022">
        <property type="protein sequence ID" value="CDM38022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6R834"/>
    <dbReference type="OMA" id="SECHARC"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="51"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM38022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="397" mass="39448" checksum="C5408B5F290B14E2" modified="2014-04-16" version="1">MKKKKNIQALSSINFKQSSTSINLQIIIPFKHQPSTDHPLQPSTSINIQPTTSTTSTTSTTSTTSTTSTTSTTSTTSTTSTTSTTSTTSTTSTTSTTSTTSTTSTTSTTSTTSTTSTTSTTSTTSTTSTTSTTSTTSTTSTTSTTSTTSTTSTTSTTSTTSTTSTTSTTSTTSTTSTTSTTSTTSTTSTTSTTSTTSTTSTTSTTSTTSTTSTTSTTSTTSTTSTTSTTSTTSTTSTTSTTSTTSTTSTTSTTSTTSTTSTTSTTSTTSTTSTTSTTSTTSTTSTTSTTSTTSTTSTTSTTSTTSTTSTTSTTSTTSTTSTTSTTSTTSTTSTTSTTSTTSTTSTTSTTSTTSTTSTTSTTSTTSTTSITSTTSMCIPSTRRGSCTFLEHKRGALFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W6R887</accession>
    <name>W6R887_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Probable transposable element</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S08g000133</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792022">
        <property type="protein sequence ID" value="CDM38082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6R887"/>
    <dbReference type="STRING" id="1365484.W6R887"/>
    <dbReference type="OMA" id="WKQDNPL"/>
    <dbReference type="OrthoDB" id="4207519at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF62">
        <property type="entry name" value="HTH CENPB-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE-1" evidence="1">
        <location>
            <begin position="5"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM38082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="204" mass="22958" checksum="5EA5A93ED46A2972" modified="2014-04-16" version="1">MGLTATWVTTIECLNAAGWALPPCIIFKGKVFLESWFEGLPGDWRFEVSPNGWTLDEIGLRWLQKLFIPATSSRMKGVYRLLVLDGHGSHLTPKFDEICVQNKIIPICMPPHSSHLLQPLDIGCFAVVKRSYGRLVEMQMRTRINHIDKHDFLEAYPSARIEAFKSETIKNSFSAAGLIPFSPDRVLSKLNICLRTPTPPPKPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W6R8I2</accession>
    <name>W6R8I2_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">amidase</fullName>
            <ecNumber evidence="3">3.5.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PROQFM164_S09g000088</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a monocarboxylic acid amide + H2O = a monocarboxylate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:12020"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:35757"/>
            <dbReference type="ChEBI" id="CHEBI:83628"/>
            <dbReference type="EC" id="3.5.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amidase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.4" evidence="3"/>
    <dbReference type="EMBL" id="HG792023">
        <property type="protein sequence ID" value="CDM38172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6R8I2"/>
    <dbReference type="STRING" id="1365484.W6R8I2"/>
    <dbReference type="OMA" id="GMQPWKY"/>
    <dbReference type="OrthoDB" id="6428749at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004040">
        <property type="term" value="F:amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1300.10:FF:000003">
        <property type="entry name" value="Amidase signature enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072:SF10">
        <property type="entry name" value="ACETAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072">
        <property type="entry name" value="AMIDASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001221">
        <property type="entry name" value="Amidase_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="7">
        <location>
            <begin position="64"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="113"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="188"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="5">
        <location>
            <position position="211"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="208"/>
            <end position="211"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM38172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="579" mass="63960" checksum="FD8EE9FA6B25B6E7" modified="2014-04-16" version="1">MLPPFDYFAYRRIRNHKQSERELRFAGLPQQYQLPISDQDRKTIDQPIAQLVHDVHDSNVSALDVLRTYGKVAKRAHERTNCVTELMLPEAESWLQSEINLKGPLAGIPVSLKDSVHVKGFDATVGYAAMAGKPILEDGPMVKLLKDAGAVPYVKTALPITLLSFESDNGLWGQCRNPHVPAYSPGGSTGGEAALLAQGGRIGIGSDVAGSVRVPAAWSGIYSLRCSTGRWPKGGVNTSMPGQEGIPSVFSPMARTLDDLTYFTRAIIRMEPWKYEHTVHPIAWRSEVESEAQNKPLRIGVMTSDGVVPPTPAIKRAITTTVAALTEAGHTVSEITTPPTADPFTGLNLASQLLNSDGCHHFNVNLKSFEPSDPGAIQLTRVANLPRPLRYLFYLYVRYIRRDKVTATLIRDFGPKSSAQVWTLTAQREAFRAAWHKWWDAEPQQFDFILCPVNATPALPHKAMHDAVSSCGYTFLWNLLDYSSGVIPVGHVDPIRDALDAPYKTVLQRLGCDNGIARGAWKHYDSAKMAGLPTAVQVVGRRWEEEHVLGYMAAVEKALEQYHDPQTSESCRYTLLEID</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W6PR22</accession>
    <name>W6PR22_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Isochorismatase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S01g000119</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the isochorismatase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PR22"/>
    <dbReference type="OMA" id="LYTVKDC"/>
    <dbReference type="OrthoDB" id="1739143at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00431">
        <property type="entry name" value="cysteine_hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="entry name" value="Isochorismatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050272">
        <property type="entry name" value="Isochorismatase-like_hydrls"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43540:SF1">
        <property type="entry name" value="ISOCHORISMATASE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43540">
        <property type="entry name" value="PEROXYUREIDOACRYLATE/UREIDOACRYLATE AMIDOHYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="Isochorismatase-like hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase-like" evidence="3">
        <location>
            <begin position="3"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM26310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="189" mass="21142" checksum="E85CD39B7940986A" modified="2014-04-16" version="1">MATVLLILDVQNGIIDRLDNTEPYLERLASTVAFARKANVKIIYVVTAFRPGYPEKNVNNISISSVAARCEYIEGQPSVQVHPTISPVAGEVILTKRRISAFFATELDMLLRCADAKSLVVAGLITSGAVLSTVRQAMDMDYRVTVLEDCCMDRDEELHRVLMEKVFAHRTDVVSANEWVEKLSIQDRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2024-10-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>W6PRL5</accession>
    <name>W6PRL5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S01g000319</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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    </evidence>
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            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <begin position="29"/>
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    </evidence>
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    </evidence>
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    </evidence>
    <sequence length="77" mass="8598" checksum="F8A91D2D6599847C" modified="2014-04-16" version="1">MSCLVLLVLALGSASHSRGILFLSPDREPLGLPYFAAAWGFLLSVMIRNTVVAVQRRHYLVWLLEAWILLSSVSMKL</sequence>
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            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PST6"/>
    <dbReference type="STRING" id="1365484.W6PST6"/>
    <dbReference type="OMA" id="ITLSMRW"/>
    <dbReference type="OrthoDB" id="2138282at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055343">
        <property type="entry name" value="CREG_beta-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37273:SF1">
        <property type="entry name" value="ADL397C-AP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37273">
        <property type="entry name" value="CHROMOSOME 8, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13883">
        <property type="entry name" value="CREG_beta-barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004879396" evidence="2">
        <location>
            <begin position="24"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="CREG-like beta-barrel" evidence="3">
        <location>
            <begin position="68"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="261"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="272"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM27243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="283" mass="30441" checksum="397F2036D069E963" modified="2014-04-16" version="1">MVSHLASILTGALALLLPLTAHGFVVPLPDNLQAFLGRLDTSTPSPNINHIEDESALNRPSWFTSTLMARRLLALSPSGVISTNFPESLPPSAHAPSDVAGLSIGLREYIADCDGSLPSDFSHDDRGDPTILGLRIGTTFKNIAAGSNLSLQLDWWDHLNEAGPVYPGLPLSPAALPRVTLFGYLENLPSPLPDDAAAALEKCFLEPHPDAKVWLPGASYSPHASFWARLVVTHAYWIGGFGDVQQIGWINLTEWQGVRPHGSVEGVGDGRGWQDVRLPGEKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W6PT83</accession>
    <name>W6PT83_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S01g001214</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the aldo/keto reductase family. Aldo/keto reductase 2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PT83"/>
    <dbReference type="STRING" id="1365484.W6PT83"/>
    <dbReference type="OMA" id="GAVYRMW"/>
    <dbReference type="OrthoDB" id="48988at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19075">
        <property type="entry name" value="AKR_AKR7A1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050523">
        <property type="entry name" value="AKR_Detox_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364:SF4">
        <property type="entry name" value="NAD(P)-LINKED OXIDOREDUCTASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364">
        <property type="entry name" value="NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="3">
        <location>
            <begin position="9"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM27403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="325" mass="36383" checksum="F35002862AEBEB9D" modified="2014-04-16" version="1">MDTPRYVFGAQGFGVAWTVDNVDHLMKSLAEAGIHQFDTAALYPATNPGESEELLGKKKPENAVIDTKILFIGDDSLSFNNMGASIEASLERLQIKQIHTIYAHAPDRKTPIPLQAAYFDHYYRKGYFQRLGLSNYSPSAIRAWMEIAVEENFIMPSVYQGQYNVFCRGYEDELFPVLREFGIAFEATSPLAGGFLTGKLSYCPSPEELEGTRFEVGEGNMLGAVYRMWYDQPVYHQAMRRLDKIGKRLGTTGAQCALRWLLFHSNLKDPDRIVIGPSTLNQLQDYVDAQKAGPLPADAAAEINALWPALKEVAATIIEKGWWSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W6PTA6</accession>
    <name>W6PTA6_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 17">Protein transport protein SEC23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="primary">sec23</name>
        <name evidence="23" type="ORF">PROQFM164_S01g000924</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16 17">Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">The COPII coat is composed of at least 5 proteins: the SEC23/24 complex, the SEC13/31 complex, and the protein SAR1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="17">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 17">Cytoplasmic vesicle</location>
            <location evidence="1 17">COPII-coated vesicle membrane</location>
            <topology evidence="1 17">Peripheral membrane protein</topology>
            <orientation evidence="1 17">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 17">Endoplasmic reticulum membrane</location>
            <topology evidence="2 17">Peripheral membrane protein</topology>
            <orientation evidence="2 17">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="17">Golgi apparatus membrane</location>
            <topology evidence="17">Peripheral membrane protein</topology>
            <orientation evidence="17">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 17">Belongs to the SEC23/SEC24 family. SEC23 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PTA6"/>
    <dbReference type="STRING" id="1365484.W6PTA6"/>
    <dbReference type="OMA" id="FPPHYAE"/>
    <dbReference type="OrthoDB" id="10256289at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090110">
        <property type="term" value="P:COPII-coated vesicle cargo loading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01478">
        <property type="entry name" value="Sec23-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11287">
        <property type="entry name" value="Sec23_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.730:FF:000001">
        <property type="entry name" value="Protein transport protein SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.380:FF:000001">
        <property type="entry name" value="Protein transport protein SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.20.10:FF:000006">
        <property type="entry name" value="Protein transport protein SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000008">
        <property type="entry name" value="Protein transport protein SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1670">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.730">
        <property type="entry name" value="Sec23/Sec24 helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.380">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012990">
        <property type="entry name" value="Beta-sandwich_Sec23_24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007123">
        <property type="entry name" value="Gelsolin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036180">
        <property type="entry name" value="Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037364">
        <property type="entry name" value="Sec23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006900">
        <property type="entry name" value="Sec23/24_helical_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036175">
        <property type="entry name" value="Sec23/24_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006896">
        <property type="entry name" value="Sec23/24_trunk_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037550">
        <property type="entry name" value="Sec23_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006895">
        <property type="entry name" value="Znf_Sec23_Sec24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036174">
        <property type="entry name" value="Znf_Sec23_Sec24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11141">
        <property type="entry name" value="PROTEIN TRANSPORT PROTEIN SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11141:SF0">
        <property type="entry name" value="PROTEIN TRANSPORT PROTEIN SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00626">
        <property type="entry name" value="Gelsolin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08033">
        <property type="entry name" value="Sec23_BS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04815">
        <property type="entry name" value="Sec23_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04811">
        <property type="entry name" value="Sec23_trunk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04810">
        <property type="entry name" value="zf-Sec23_Sec24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82754">
        <property type="entry name" value="C-terminal, gelsolin-like domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81811">
        <property type="entry name" value="Helical domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82919">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 17" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="15 17" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="9 17" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11 17" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="13 17" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="14 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 17" id="KW-0653">Protein transport</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 17" id="KW-0813">Transport</keyword>
    <keyword evidence="10 17" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zinc finger Sec23/Sec24-type" evidence="19">
        <location>
            <begin position="60"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 trunk" evidence="20">
        <location>
            <begin position="127"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 beta-sandwich" evidence="22">
        <location>
            <begin position="403"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 helical" evidence="21">
        <location>
            <begin position="521"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="domain" description="Gelsolin-like" evidence="18">
        <location>
            <begin position="635"/>
            <end position="722"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00025471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU365030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF04810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF04811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF04815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF08033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="CDM27115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="769" mass="85438" checksum="D54148B932BA17A1" modified="2014-04-16" version="1">MDYEALKDQWSDVEDRDGLRLSWNTFPSTRMEASRLVVPIAAVYTPLKEKPDAPLLQYEPVTCKQPCRAVLNPYATVDVRARVWICPFCLSRNPLPPHYKDITENTIPPELHPQSTTIEYQLARPAPAPPIFVFVVDTCQEDDSLQAVKDSLIMSLSLLPPNALVGLITFGTMAQVHELGYIECAKSYVFRGNKEYNAKQVQEMLGLSGGVRPGVPQQQPARPPLGPAARFLMPVQQAEFQITNVLEQLQRDPWPVANDKRPLRCTGVALSVAVGLLESSFQNAGGRIMTFTSGAATEGPGHVVSPELKEPIRSHHDIERDNIKYYKKAVKFYDALAKRAANNGHIVDIFAGCLDQVGLLEMKNLSNFTGGYMLLTDSFTSSQFKQSFVRVFDKDAADNLLMGFNASLEVLTTKELKVTGLIGHAISLNKKSSSVGETECGIGNTCAWKMCGMDPSSSYGIYFEIANQGGPAAVQPGPQRGMIQFLTYYQHSSGHYHLRVTTTARPLSGPAGDPTLAQSFDQEAAAVLMARIAVFKAEVDDGPDVLRWVDRMLIRLCSRFADYRKDDPTSFRLEKNFTLYPQFMFHLRRSQFLQVFNNSPDETAFYRHVLNHEDTGDSLVMIQPTLDSYSLEQEGAQPVLLDSASIQPAHILLLDTFFHILIFNGETIAEWRKAGYHEQEGYENLKLLLEQPKEDARDLISDRFPLPRFIVCDAGGSQARFLLSKLNPSTTHTTGGYGGGVSSQTIFTDDVSLQTFMDHLMKLAVSGTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>W6PTS6</accession>
    <name>W6PTS6_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Probable transposable element</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PROQFM164_S01g001054</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1365484.W6PTS6"/>
    <dbReference type="OMA" id="PWHQSEL"/>
    <dbReference type="OrthoDB" id="6513042at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
        <property type="term" value="C:nuclear body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001147">
        <property type="term" value="F:transcription termination site sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006369">
        <property type="term" value="P:termination of RNA polymerase II transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18042">
        <property type="entry name" value="DEXXQc_SETX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001152">
        <property type="entry name" value="tRNA-splicing endonuclease, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001576">
        <property type="entry name" value="tRNA-splicing endonuclease, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024481">
        <property type="entry name" value="Helicase_Sen1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056474">
        <property type="entry name" value="SEN1_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887:SF495">
        <property type="entry name" value="HELICASE SENATAXIN ISOFORM X1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23576">
        <property type="entry name" value="SEN1_barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12726">
        <property type="entry name" value="SEN1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="1920"/>
            <end position="1934"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="1937"/>
            <end position="1953"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="873"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="924"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1840"/>
            <end position="1887"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1970"/>
            <end position="2159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="965"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1031"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1857"/>
            <end position="1868"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1970"/>
            <end position="1988"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="2000"/>
            <end position="2012"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="2022"/>
            <end position="2032"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDM27245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="2159" mass="241318" checksum="51AB1C380231FEA1" modified="2014-04-16" version="1">MEFLAAIRELKALPETTHLFCPRKDNDDHGRYEDLEQVDESGKAVKDIVAEATARRESFLSSMRILAYHKDGVEDDQNWILGKLDESLEKCDLCIKHYYIGKIWLMDLLKEENYHEDDIEAFAQRIDEWDIRRITRNLTTATTQLKQIPLEKISLDVLDRAALLSIFETLSCEAMLRNESLLQEYFDEPFKLIQTKRSLKVSDYIPAVSRFLFDSNQFRSFWAVQSWTRYSRPPTNQEFDWAVRDGLLMGLRAASQQPPQFAVIQRLWRGMQLVVRKLDKEQITHQLRGLEIDPCRLSVDHLAIPAPSLRFLLNTIQLFLEKAPVDFWDAMQTISPQAIMEQAFYNTQFNAFLLETSEGEPFEKSALKDMLSWINPFLGSLKGAHQPSACRFLILQLLGRLQDTQYPNLSRYHCFDIGLASLLQTLRRFTENESSRGTVTRIVLAETMGVVGDTIDAIISPPTFDVERSRQNGILTQCMEVVRNTLALECQSLKTDYEALLKHGTLSHGVSTYSAPIWDAVIKHLHRDNLPLSSSALLGILPLVGLEMFPTKGEGNKEKTHFNMIYGHLTNLSCRIIERLADFPPEHLETLFQSQDTSSAVISALFAADYDTYTAAVDLIKAVSGQSARRDAISHLLQSSFTTTIYGLSWSFRRISHMKTFAPAPRMLYTGTDIVEILCDSQTGMLRTRNLADRREVVSLQKLWEYLWLALTTIFDETEAWHLRGNDKAVMLEFCRDTIQFADLLFDQYGVFLGAVGNADPGQTSASENFLKSPTATMSAMVKWLRLKDEFLATTLVGLVAKLLRRLGGMNVTTVKPDALSFIEGVAVNGTIKTILNQREKAELVRSLEAYYKKPVVTASTAALKKQSSITAFAKPSASSPSSRITSDDDFDDDTLNDQTLLELSSSVEFNKARLATQAKRAAEKATKMHSSTALKNRPDIFPPRMFPKSVPPLRSNNDPTHVLSFREKREREREAKKKRDQIELARLKKNTTAYGVGEQTAEQGSGLKGIGIKGKDHTTPADSMMVSSGDESDSESEDELDKELFGAKPKKPDAVAAYELSKKQSLQQQPIRKVKRHRSVRDMRARLAPDLSSLHRSILSWDFFATGDLPPSSDRTDYSLVSNTFRTPDAYQSTFEPLLILEAWQGFQQAKDEGSFRPFEVKVMTRLAVDSWIEFSTQPLGVLPKDFSMGEGDLVMFSSSPKLTSDPSAPHVLARVCGVNRKNKKMEVTYRVNPGSNKFLSSLGPGTEAWGAKITSLIPVEREYGALMALQYYDLCEEIVLAKPSPLLTYSDARLQPIMDNYSINRAQAKAIKSAVDNDAFTLIQGPPGSGKTKTIIALVGSLLSDVLGKQVIKVNGAPVARNSLSKKLLLCAPSNAAVDELVMRLKDGVRTTHGRQEKVSVLRLGRSDAINTNVLDVTLDEMVNARLNQDPSKGNGVDLQKLYEEHKTTDTSFKELRGRLDEARAKGLPPPEELEREFHLMKKKRSQLSTSIDKARDQNHTLARNADMHKRRIQEQIINEAHVICTTLSGSGHEIFQGMNVEFETVIIDEAAQCIELSALIPLKYGCSKCVLVGDPKQLPPTVLSKMASKFQYEQSLFVRMQKNHPRDVHLLDIQYRMHPAISHFPSVTFYDGKLQDGPDMAKLRQRPWHQSELLSPYRFFDVQGMHSSAARGHSLINYAELQVAMQLYDRLITDVKEYDFAGKIGIITPYKGQLRELKNQFTQRYGEDILKKVDFNTTDAFQGRESEIIIFSCVRASNKGIGFLADIRRMNVGLTRAKSSLWVLGNSQSLEQGQFWSRLIQNARERNVYTEGDIVKILEKPQFTGYKEIEMVDLDTAEAPGSPDYEPPVPPISRPSSASVSVSASGHGTSPIPQPDGPSGGAKGLDPTKMCGICGSANHFTYNCDNDEAKANARGTCFRCGQPGHTKISCRAERCVECGECGHSSRNCTSTKVLSKIEKSRLERDEYILKQRQDSSTERQRERQLGGHNPKIPVVRATNSTAPINTLDNSAKRKREESSSNGPQAQRPRTGQPHPPIHVSKGSLGSNHPGLSGPAARGSNVPRVSGHPGLSGPPRDNLVANTQNGYKGPLANGSPGGLIKPSRDGQAYPTENDPTRAPPMRSGADVPNQAAPKPRPPIMRKKKATDPFIRPKPKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W6PUK6</accession>
    <name>W6PUK6_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S01g001709</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PUK6"/>
    <dbReference type="STRING" id="1365484.W6PUK6"/>
    <dbReference type="OrthoDB" id="4358334at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM27898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="107" mass="11900" checksum="4F9F8A08F832A9DA" modified="2014-04-16" version="1">MLPKPISVSGIKSQYISNEWIELDVYFIGPQATAKLTIEAYLVQDLEAKLPAGIDVLGPEGFILNFDQKVARIASYNNMEFRISVNVCVDSENERLVTSQTKTLSFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W6PUW8</accession>
    <name>W6PUW8_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">RNA polymerase II subunit B1 CTD phosphatase RPAP2 homolog</fullName>
            <ecNumber evidence="12">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PROQFM164_S01g001496</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Putative RNA polymerase II subunit B1 C-terminal domain (CTD) phosphatase involved in RNA polymerase II transcription regulation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11 12">Belongs to the RPAP2 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="12"/>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PUW8"/>
    <dbReference type="STRING" id="1365484.W6PUW8"/>
    <dbReference type="OMA" id="IQAQKDT"/>
    <dbReference type="OrthoDB" id="2590500at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043175">
        <property type="term" value="F:RNA polymerase core enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008420">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039693">
        <property type="entry name" value="Rtr1/RPAP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007308">
        <property type="entry name" value="Rtr1/RPAP2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038534">
        <property type="entry name" value="Rtr1/RPAP2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14732">
        <property type="entry name" value="RNA POLYMERASE II SUBUNIT B1 CTD PHOSPHATASE RPAP2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14732:SF0">
        <property type="entry name" value="RNA POLYMERASE II SUBUNIT B1 CTD PHOSPHATASE RPAP2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04181">
        <property type="entry name" value="RPAP2_Rtr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51479">
        <property type="entry name" value="ZF_RTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7 12" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RTR1-type" evidence="14">
        <location>
            <begin position="104"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="274"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="310"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CDM27685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="320" mass="35637" checksum="40787758627876C5" modified="2014-04-16" version="1">MAHQGPSHALKTSLPETYAAINAQRPPPSYLYPTQEEQDKYLEGRPGATQQHLEVALEHAQQIQTQKDAEDVILNRILELLELPSSPTADPAAPSQEDAVKLKYSLAPFRPSDYDNLILERNFEDLCGYALCPHKHRKQDNGPRGGFQFKYGPKGSGPGGRGRSVEIVSQDRIEKWCSDACAERALWIRVQLSEKPVWERRAGDTRGTSILLLEEARAKRLKAPAATSSISSVVDDLQSMGLGNRNRSRELALERGDTSLIRPDGRVNVDIRENQRGSQQVAAAPQMRPEDARGGSIEGYVPRERRDVDQDGDIDLLDRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>W6PWH4</accession>
    <name>W6PWH4_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">WD40 repeat protein poxJ</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Oxaleimides biosynthesis cluster protein J</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PROQFM164_S01g002429</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat rae1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PWH4"/>
    <dbReference type="STRING" id="1365484.W6PWH4"/>
    <dbReference type="OMA" id="YSHNTRD"/>
    <dbReference type="OrthoDB" id="256303at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000190">
        <property type="entry name" value="Nuclear pore complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10971">
        <property type="entry name" value="MRNA EXPORT FACTOR AND BUB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="261"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00074082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00081246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM28618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="358" mass="39337" checksum="BA58C9C2EDE070D1" modified="2014-04-16" version="1">MAFNAQNTTNQGDISQDAILDHPPEDSISELAWSPIANHLAVSSWDHNVRIYDVTRSVKGEGKAMFSFGGPVLSCAWSPDGSKVVGAGADGSARLVDLASGNPTTAQAQQVAQHDAPVRSVRMVQIPNSQVPIVVTGSWDRTVKYWDLRQSTPLGVLECSERVYAMEICQGQLLVALADRQISLVNLNQPTSVFKTLQSPLKHQTRTICWIPDGSGFAVGSIEGRCGVNYIDDAKKQSNFTFRCQRTPKDNDPKNQLVYSVNAVSFHPRYHTFSTAGSDGTYCFWDKDAHHRLKSFPAVGHSITSTAFNLDGSIFAYAIGYDWSKGYAYNTRDYPTKIALHPVSDAECKPKATMTTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W6PXB4</accession>
    <name>W6PXB4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Smr protein/MutS2 C-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S01g002406</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PXB4"/>
    <dbReference type="STRING" id="1365484.W6PXB4"/>
    <dbReference type="OMA" id="DYIFREN"/>
    <dbReference type="OrthoDB" id="3231855at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013899">
        <property type="entry name" value="DUF1771"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002625">
        <property type="entry name" value="Smr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036063">
        <property type="entry name" value="Smr_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053020">
        <property type="entry name" value="Smr_domain_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47417">
        <property type="entry name" value="SMR DOMAIN-CONTAINING PROTEIN YPL199C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47417:SF1">
        <property type="entry name" value="SMR DOMAIN-CONTAINING PROTEIN YPL199C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08590">
        <property type="entry name" value="DUF1771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01713">
        <property type="entry name" value="Smr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01162">
        <property type="entry name" value="DUF1771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00463">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160443">
        <property type="entry name" value="SMR domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50828">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Smr" evidence="2">
        <location>
            <begin position="98"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="193"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM28595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="245" mass="27508" checksum="47C7207498CA9D79" modified="2014-04-16" version="1">MSHEMSQLGPRAFNHASSSDAEAEYDRLRDLARQEASKRGECFSRSKEAYSSGDGAGAKQLSEEGKAHGRKMEEYNKQASEFIFRENNANGRVEADTIDLHGQFAEEAEEILEERIKYAKSHGQTHLHVIVGKGNHSANHIQKIKPRVEQVCRELGLQYTTEDNDGRIYVNLTGGEAVMPPSTGYQGGAGYPGQQQGHQQHQQQQHGQGHQQQQQQQQPDELEELAKKFVPRILRKLEKACCVVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W6PXJ6</accession>
    <name>W6PXJ6_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S01g002759</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PXJ6"/>
    <dbReference type="STRING" id="1365484.W6PXJ6"/>
    <dbReference type="OrthoDB" id="5361958at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM28948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="367" mass="41252" checksum="C9239E7D9EDFA5E6" modified="2014-04-16" version="1">MQQRLSAVETLRFQMPYVAFGSRQQTYETLLHSHPESTAPPEQPTASHQPKFFTWVTNNGYGARNASDPAPFSLWDDHVHDFRFPTPEERKWIVDAFRAESVTYSWPDIIIETRFPPNPIPLTVACVAATFIPAGSNWPYLTTNTDYSNPRLPDPLSPHFQLPKWERPSEKQREAVLRALGRLVTVQAVNYIAPIIIVEIALDGRSYSTRSLPGRVGGLLTVYHHSHTPFWPLTCQSRERCITPGTVQDTTNYFLTDLQTLCPEVRVECGLTNRDSGYLDATMASTAGVKLRNTDSGYIRLTVSNHGFINSDEVYHPSSQNGGVCIGHIDERFDALDVALVKLYPSTTFTNGEYFPSPASESPHPFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>W6PY19</accession>
    <name>W6PY19_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="10">PPIase</shortName>
            <ecNumber evidence="10">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">cyp6</name>
        <name evidence="14" type="ORF">PROQFM164_S01g002965</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 10">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 16">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the cyclophilin-type PPIase family. PPIL4 subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="10"/>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PY19"/>
    <dbReference type="STRING" id="1365484.W6PY19"/>
    <dbReference type="OMA" id="APKCCEN"/>
    <dbReference type="OrthoDB" id="2083at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01921">
        <property type="entry name" value="cyclophilin_RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12235">
        <property type="entry name" value="RRM_PPIL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000015">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000377">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035542">
        <property type="entry name" value="CRIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035538">
        <property type="entry name" value="Cyclophilin_PPIL4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45843">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-LIKE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45843:SF1">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-LIKE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 14" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 10" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="12">
        <location>
            <begin position="6"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="13">
        <location>
            <begin position="248"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="379"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="393"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="425"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDM29153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="444" mass="50596" checksum="1FFFF89B6A7BFCE5" modified="2014-04-16" version="1">MSALLETSLGDIVIDLLVDDAPKACDNFLKLCKLKYYNFSPIHSVQKNFTFQTGDPLGPDAPESDGGSSVWGLLDGPSKRTFPLQASRTLKHLERGTVSMATVPAKNDPDQRLAASQFIITLGDNLDYLDGKAVIFGKVVEGFDVLEKINESFIDDRGRPLKDIRIRHTTVLDDPFDDPPNLVEPPESPVPSKAQLATVRIADDEDLDDDMDEEAMDKLRREREARAQALTLEMVGDLPFADVKPPENILFVCKLNPVTQDEDLNLIFSRFGTILSCEVIRDKRTGDSLQYAFIEFEEQKACEQAYFKMQGVLIDDHRIHVDFSQSVSKLSESWRNSTVTKRRQRGGFGGVADLEAKRQYRELDEAPIDEDDARYLFDKRNKNRGAPAPPREAPSDRTRGRRDRGSRSPRREQDRYRRRSYSRSPQRDSRRDSRKERSYNHRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W6PY34</accession>
    <name>W6PY34_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Large ribosomal subunit protein mL38</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PROQFM164_S01g002696</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the phosphatidylethanolamine-binding protein family. Mitochondrion-specific ribosomal protein mL38 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PY34"/>
    <dbReference type="STRING" id="1365484.W6PY34"/>
    <dbReference type="OMA" id="FRTQWDE"/>
    <dbReference type="OrthoDB" id="2153661at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00866">
        <property type="entry name" value="PEBP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1180:FF:000001">
        <property type="entry name" value="Mitochondrial large ribosomal subunit YmL35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.280.10:FF:000004">
        <property type="entry name" value="Mitochondrial large ribosomal subunit YmL35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.280.10">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008914">
        <property type="entry name" value="PEBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036610">
        <property type="entry name" value="PEBP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035810">
        <property type="entry name" value="PEBP_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11362">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11362:SF82">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01161">
        <property type="entry name" value="PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49777">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDM28885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="418" mass="47876" checksum="2E11491CA571DA1B" modified="2014-04-16" version="1">MAHCERASKPLLQCLRNTYSRGVAGVQLQTRAFQSTASVRDAEVETPAQPFHKAPDPSLVTSPRLERRLLRQGTAPIGSRRRRAALQDSENLPFEQLPYQCFQEARKILLADREEKLKEIEMMRQRLARQEALSVEEAGGAKAKKSRVTAMQLHLERLKVLADINDPLVKRKFEDNEGDMSKPIYRFLADRKWREYRRKILVQRITQMNVIPDVLPHCDPVVETKLYFGKRQIQAGEFVEARLSTSAPKLDVQIFEAGEKLVTIAVVDPDVPNVENDNFDYKTHFLAVNVPISATSTKIDLAQLLEDSQVVLPWLPPVAQMGSPYHRLSLFIMEQKESQPLDFAAVKAKESNRDTTLLRSLQSRYHLKAIGAHLFRTQWDATTLEVMKEIGFDGANVELRRKRVEPLPYKRRNPSSFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W6PYH3</accession>
    <name>W6PYH3_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">protein-ribulosamine 3-kinase</fullName>
            <ecNumber evidence="1">2.7.1.172</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S01g002886</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>N(6)-D-ribulosyl-L-lysyl-[protein] + ATP = N(6)-(3-O-phospho-D-ribulosyl)-L-lysyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48432"/>
            <dbReference type="Rhea" id="RHEA-COMP:12103"/>
            <dbReference type="Rhea" id="RHEA-COMP:12104"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:90418"/>
            <dbReference type="ChEBI" id="CHEBI:90420"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.172"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="2">
            <dbReference type="Rhea" id="RHEA:48433"/>
        </physiologicalReaction>
    </comment>
    <dbReference type="EC" id="2.7.1.172" evidence="1"/>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PYH3"/>
    <dbReference type="OMA" id="CNRFGDE"/>
    <dbReference type="OrthoDB" id="5772781at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102193">
        <property type="term" value="F:protein-ribulosamine 3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016477">
        <property type="entry name" value="Fructo-/Ketosamine-3-kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12149">
        <property type="entry name" value="FRUCTOSAMINE 3 KINASE-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12149:SF8">
        <property type="entry name" value="PROTEIN-RIBULOSAMINE 3-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03881">
        <property type="entry name" value="Fructosamin_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00048655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM29075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="367" mass="41615" checksum="7BA8B9EA914985B3" modified="2014-04-16" version="1">MKYNGADGLEFEAGNTKIDPAVLHELPEGCRVSSTENHGVSFWAQTGRIDVLLRNGTPQSFFIKVISKGLGMDMTRGEFQSMSAIHKFLPEFVPRPIACGTYSTIPDTHFFLCEFREMTDDMPDPHKFAALLSKLHQQSVSPTGKFGFHITTYAGNLPQFVAWEESWEVFFAKTMRQALDLEIERKGPSEELDVLSSALFEMVIPRLLRPLESDGRTVKPSLVHGDLWYANAGIDVDQDQPLVFDACSFFAHNECTFSYEKLAVARTKIFNFGDEFGQWRPACNRFGDEYVAAYNTFAQISPPEEDFQGRLDLYRLRFDTHVSALFVDNETLRTQVLDVMRDLVQRYGKCVLGGSLGHKHKKPQKNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W6PYQ4</accession>
    <name>W6PYQ4_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Dipeptidase</fullName>
            <ecNumber evidence="2">3.4.13.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S01g002672</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>an L-aminoacyl-L-amino acid + H2O = 2 an L-alpha-amino acid</text>
            <dbReference type="Rhea" id="RHEA:48940"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:59869"/>
            <dbReference type="ChEBI" id="CHEBI:77460"/>
            <dbReference type="EC" id="3.4.13.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.13.19" evidence="2"/>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PYQ4"/>
    <dbReference type="STRING" id="1365484.W6PYQ4"/>
    <dbReference type="OMA" id="IEYASKP"/>
    <dbReference type="OrthoDB" id="445695at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070573">
        <property type="term" value="F:metallodipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008257">
        <property type="entry name" value="Pept_M19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10443:SF12">
        <property type="entry name" value="DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10443">
        <property type="entry name" value="MICROSOMAL DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01244">
        <property type="entry name" value="Peptidase_M19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51365">
        <property type="entry name" value="RENAL_DIPEPTIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0224">Dipeptidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU341113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM28861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="197" mass="21619" checksum="C477EC91D793EAC9" modified="2014-04-16" version="1">MQLTYNTQNYSGAGYTEIRDSGLTRFGRQVVDEMGRLGIVVDLSHVGPVTSEDVIEYASKPPCFGHVLPGGLHEHPRNKSNYLLRLIGKKGGFVGISQFGPHMARGNESTIDDYVTAVDFVIDLIGEDLVGVGSDANKGYARRLTPWGSQTAVKPLGPLKERPELAKAMARAGWSKSKMQKVLGENWLDYLERIIGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q034</accession>
    <name>W6Q034_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g003118</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q034"/>
    <dbReference type="OMA" id="YLAYNRP"/>
    <dbReference type="OrthoDB" id="4357081at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM29306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="237" mass="26355" checksum="72A0D000474DB231" modified="2014-04-16" version="1">MSVMLDTTSARLFHTTRIGFQTRCQQLIDDFLHDGLSLQDEFHDRVDQLHLSLEQLKRAGQMMAIDCSTNELVAVVPIGFFTVLIERPGQDPMAEFDWACIYTTDTLNMLTSESFLRHRAPADIARILETQSFLWDLVVPFPVTLSCAEDSAPDPYVNALQIPPAASLARMNSQIPVRPRPTPPVDTYMAYNRPVPGPYPPALPPRSVFESEPESDGESPTGANAVGLYGNPSMHPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q095</accession>
    <name>W6Q095_PENRF</name>
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        <submittedName>
            <fullName evidence="4">Zinc finger C2H2-type/integrase DNA-binding domain</fullName>
        </submittedName>
    </protein>
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        <name evidence="4" type="ORF">PROQFM164_S02g000087</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM29938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q095"/>
    <dbReference type="OrthoDB" id="40579at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="14"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="32"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM29938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="55" mass="6430" checksum="A6C7DA60D7A1E57F" modified="2014-04-16" version="1">MSDTTGPDVTRRGKQCSYCDRAFARREHICRHERSPRSVKPFGARDINQMFSRSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q099</accession>
    <name>W6Q099_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amino acid/polyamine transporter I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g003522</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q099"/>
    <dbReference type="STRING" id="1365484.W6Q099"/>
    <dbReference type="OrthoDB" id="3257095at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM29710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="94" mass="10513" checksum="6F0D85A2586C738C" modified="2014-04-16" version="1">MTVAILLSLINISSDTTIEDIVSIVVSGIYPSYLIVSIFLFYRRVRGDISRYNDNEDDIINSIVAIGGSVFLAIIYYVVRARHIYKGPIVEVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q0H5</accession>
    <name>W6Q0H5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SET domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PROQFM164_S01g001525</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q0H5"/>
    <dbReference type="STRING" id="1365484.W6Q0H5"/>
    <dbReference type="OMA" id="HSCDYNS"/>
    <dbReference type="OrthoDB" id="5945798at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050869">
        <property type="entry name" value="H3K4_H4K5_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197:SF251">
        <property type="entry name" value="EG:BACR7C10.4 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01360">
        <property type="entry name" value="ZF_MYND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SET" evidence="5">
        <location>
            <begin position="8"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="MYND-type" evidence="6">
        <location>
            <begin position="59"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM27714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="495" mass="55970" checksum="C53915B689E808E4" modified="2014-04-16" version="1">MASRIALPSVTTRTVPQPAPNGLGNGLFATADINPGEDVLHIKTPFVAVLDSPRLEDTCAGCFGKRQVETGNELKACTGCRVVKYCDRVCQSKDWKFAHSLECPIFKKVKPMVLPNNARALLRVVLRTARSKYDAEEFKVFDGLETHINEISESQGQLDRINLTARAVKNYSGTDVDEGTIASYAAKLDLNSFNLTTSMYDRIGLYMHPYAGLINHSCAYNSTVGFDGEELYVKAMRPIKKGEQIFISYIDTTTPYDIRRNELKERYFFDCQCTKCQMGTDTIEDRFLSIPEDMTSLETAEREALELMQKATATSTEPADAIEKLEAAMHKLHETALWPLTRQPYASLRDKLIISLLTAGKFTRAFIHAAIRYLRIDPVVYDKAHPIRHIHAWSLVRLTVFISQEGFQPDPKDPVQIHDFKLNFHYLIWYILAELTSTQAESCTVPSFKRLVGNQFLQVHNEFKANGIDPSKTKAVLSAEWNKLERLVDKALEKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2024-10-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q0L0</accession>
    <name>W6Q0L0_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S01g003613</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q0L0"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM29800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="45" mass="5123" checksum="816135B7C0026D55" modified="2014-04-16" version="1">MLYHLHSCPSSTPPNHIVIASLVNLGNAYRYLYLRLSCSSPYTRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q102</accession>
    <name>W6Q102_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S02g000139</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM29990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="OMA" id="DCYAFDV"/>
    <dbReference type="OrthoDB" id="4924482at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054208">
        <property type="entry name" value="DUF6914"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21858">
        <property type="entry name" value="DUF6914"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM29990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="180" mass="20505" checksum="5C5FC1C8FEA340DB" modified="2014-04-16" version="1">MSNKRQVFVSLHHRDSPSLGGNRQRLGYAAYHWGILISPKNSKGLDCYAFDVSDGLILDPVNRLNCNEGYNWHFREKVNVDPTQGGHLIGMVMVGKVPHEAIDAQIYGLLKAIPLPQKGSRPEQNCVTWTKAVIYTLRENGFVEIFDIDRFMDKTLAFADQRIHRTKSTPDRINYTSRSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2024-10-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q105</accession>
    <name>W6Q105_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g001695</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q105"/>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM27884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="51" mass="5840" checksum="A79708201CDA40EA" modified="2014-04-16" version="1">MPGAKWGALVNQAPESSERTRSRVYSSYHELHMYRTMYTYLRGSSGSNNPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q177</accession>
    <name>W6Q177_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Vacuolar iron transporter 1.1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">VIT1.1</name>
        <name evidence="7" type="ORF">PROQFM164_S01g003539</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CCC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q177"/>
    <dbReference type="STRING" id="1365484.W6Q177"/>
    <dbReference type="OMA" id="EADHYHT"/>
    <dbReference type="OrthoDB" id="73465at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005384">
        <property type="term" value="F:manganese ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030026">
        <property type="term" value="P:intracellular manganese ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02435">
        <property type="entry name" value="CCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008217">
        <property type="entry name" value="Ccc1_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31851">
        <property type="entry name" value="FE(2+)/MN(2+) TRANSPORTER PCL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01988">
        <property type="entry name" value="VIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="162"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="193"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="223"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM29726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="255" mass="27777" checksum="BBF84593B7523F67" modified="2014-04-16" version="1">MASTINMASEHVVEQLNQNHAANEKHFDSGEVMRDMIIGLADGMTVPFALTAGLSTLGSSKLVILGGLAELFSGSISMGLGAYLAAVTDRDHYASEEKREREEVVSKPNAEKEEIHEILSNYGISREASQNVVDCLSENHENWIRFMMDFELKMEEPNVSRAWISAATMGISYFIGGLLPMIPYFVMHKVVDALFVSIGITIVILVGFGFIKNYVVIKTKQAGLYGAAQALLVGTIAAGTSYGIVYGIDHSNLYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q1J6</accession>
    <name>W6Q1J6_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="6">N-terminal acetyltransferase A complex catalytic subunit ard1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ard1</name>
        <name evidence="6" type="ORF">PROQFM164_S02g000344</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the acetyltransferase family. ARD1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1365484.W6Q1J6"/>
    <dbReference type="OMA" id="LPENYFM"/>
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    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031415">
        <property type="term" value="C:NatA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990189">
        <property type="term" value="F:protein N-terminal-serine acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990190">
        <property type="term" value="F:protein-N-terminal-glutamate acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045047">
        <property type="entry name" value="Ard1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23091">
        <property type="entry name" value="N-TERMINAL ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23091:SF4">
        <property type="entry name" value="N-TERMINAL AMINO-ACID N(ALPHA)-ACETYLTRANSFERASE NATA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0808">Transferase</keyword>
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        <location>
            <begin position="23"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="195"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="204"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDM30195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="246" mass="27739" checksum="C18A228CFE700362" modified="2014-04-16" version="1">MVDIVPLSSYPSYIDLLPSIQTCNITNLPENYFLKYYLYHALTWPQLSFVAVVRPRGGHKPGPKGVGMAGNISGEYPKVVGYVLAKMEEEPTDGNQHGHITSLSVMRTHRRLGIAERLMRMSQRAMAESHRAHFVSLHVRMSNIAALRLYRDTLGFEVEKVEDGYYADGEDAYAMRLNLQNLWLDWKAIEKRDAENNKEKNGEEGNEDEGEEVGELGKKDAEKMIRVKVGRGLGVGDLVEKNESKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q1N5</accession>
    <name>W6Q1N5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S01g001940</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q1N5"/>
    <dbReference type="STRING" id="1365484.W6Q1N5"/>
    <dbReference type="OrthoDB" id="4368229at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004879540" evidence="2">
        <location>
            <begin position="18"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM28129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="113" mass="10884" checksum="684085F4218CD4B2" modified="2014-04-16" version="1">MRYTLIAPILLAVTALAVPVPKQNDVIGDAGVAVNIGGDKTAGVAKRGDGGGGHGGGSDDDDSSSDLIGKLGAAINVGGAETTGVAKRSETDVISELGIAANVGGDKTTGVAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q285</accession>
    <name>W6Q285_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="7">TATA element modulatory factor 1 TATA binding</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PROQFM164_S02g000569</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q285"/>
    <dbReference type="STRING" id="1365484.W6Q285"/>
    <dbReference type="OMA" id="EEMHGYI"/>
    <dbReference type="OrthoDB" id="74178at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052602">
        <property type="entry name" value="Growth_transcription_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022092">
        <property type="entry name" value="TMF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022091">
        <property type="entry name" value="TMF_TATA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46515:SF1">
        <property type="entry name" value="TATA ELEMENT MODULATORY FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46515">
        <property type="entry name" value="TATA ELEMENT MODULATORY FACTOR TMF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12329">
        <property type="entry name" value="TMF_DNA_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12325">
        <property type="entry name" value="TMF_TATA_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TATA element modulatory factor 1 TATA binding" evidence="6">
        <location>
            <begin position="756"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="34"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="203"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="327"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="469"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="631"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="533"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="768"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="60"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="73"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="121"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="137"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
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            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="480"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="663"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="689"/>
            <end position="713"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM30420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="871" mass="96608" checksum="B6008940FE1C49D3" modified="2014-04-16" version="1">MAQNSQAQKPKWGVGSFFQQAVAGVESRLDLILMDEEGNQTNSTAKPTEIQGGDAPLTKAPASSVSRSSSTARRNDRLQERLARAMVKQNASNLSSHSPQSRVSSPPASPVPSNEPRSSMDIDSSVASVNSAVEDSEISRPNDDSIADKLASPRISYDSGISPRVSTDISVADSAPRISVEVAQSSTDSAKASQEISDLQRNSVLSDIGLGDSPRVSVESPEVPEENENPDIARLKAEHKTAESQWQEEMHGYIERIDALQSKLKYLAKDAAESAKNAAANATPGSAQKQLLEKDEKIALLLEEGQKLSKSEMDHRTVIKKLRQQLTENTKSQIEMKRKTDKLERDLVNSEARAKRAEAAEKRATESLSSQTKSTKDLEAVTNERNALSQTVQEMKSQLSRAVSRAETAETKANSDALELERQRATELDEELCNLKIERDITEEKSKREITELKEKVEQEKERARMLEAELKGEQSVLESKMETLRSRAEEASSGATGETQAKLLRQIETLQTQYAAASGNWHTLEGSLLSRLASVEKERDDAGRREADLRKKIREMNQKLKKFEEELDNAKEAEHDLSSKLEERMEELQKLQHKLEKATEALASTQKDMAEQKKTCDSTWAQKLEEERAKWREQVNSPSQLRGVSPVASLRRSSTLDAAMTPGPSDFRPPSRRSSTMAFTSPEIGTPPRQNSYPASITQATLSPPHINTNPSFMAAPSITFEPEEYFESGTPVTPSAYGGTHAPPSRGINDIISESTVGAGPSVQLVERMSATVRRLESERAGSKDELARVTTQRDEARQQVVDLMRELEEKQLSYSRVEELEAELEDLDQRYQTTLEMLGEKSEQVDELNADIADLKKIYRELVDSTMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2024-10-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q2K9</accession>
    <name>W6Q2K9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S02g000709</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q2K9"/>
    <dbReference type="STRING" id="1365484.W6Q2K9"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM30560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="62" mass="7054" checksum="FF09F7A1933731E2" modified="2014-04-16" version="1">MEASSLNALSEDTMYFWNISLLQGKTYQTAMTPVHGGIYLLHGEAKTSSSRCIILRRKQQYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q2P8</accession>
    <name>W6Q2P8_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">alpha-amylase</fullName>
            <ecNumber evidence="4">3.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">PROQFM164_S02g000390</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endohydrolysis of (1-&gt;4)-alpha-D-glucosidic linkages in polysaccharides containing three or more (1-&gt;4)-alpha-linked D-glucose units.</text>
            <dbReference type="EC" id="3.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.1" evidence="4"/>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q2P8"/>
    <dbReference type="STRING" id="1365484.W6Q2P8"/>
    <dbReference type="OMA" id="NAQLCQT"/>
    <dbReference type="OrthoDB" id="204980at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004556">
        <property type="term" value="F:alpha-amylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11319">
        <property type="entry name" value="AmyAc_euk_AmyA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000120">
        <property type="entry name" value="Alpha-amylase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013777">
        <property type="entry name" value="A-amylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015340">
        <property type="entry name" value="A_amylase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357:SF220">
        <property type="entry name" value="ALPHA-AMYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357">
        <property type="entry name" value="ALPHA-AMYLASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09260">
        <property type="entry name" value="A_amylase_dom_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001024">
        <property type="entry name" value="Alph-amyl_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8 14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="16" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="17" id="KW-0732">Signal</keyword>
    <keyword evidence="16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004881245" description="alpha-amylase" evidence="17">
        <location>
            <begin position="24"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="525"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="18">
        <location>
            <begin position="36"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="12">
        <location>
            <position position="233"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="12">
        <location>
            <position position="257"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="323"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="370"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="13">
        <location>
            <position position="323"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="53"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="177"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="465"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001024-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001024-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001024-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR001024-5"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CDM30241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="547" mass="60529" checksum="9CC853B9D30A32B1" modified="2014-04-16" version="1">MSRSTLGRLVGLLITGLISSASAARTVDWKPRSIYQTMTDRFARTDGSLTAPCNTTAGFYCGGTWRGTIDRLDYIQGMGFDAVMISPIIENIHGQVSYGEAYHGYWPLNFNTLNSHFGTHQDLLDLSAALHSRGMYFMMDTVINNMAYITNGSNPATHIDYSVFTPFNNADYFHPYCKIKNWENMTDAQRCQTGDLDVPLPDLFTEHADVQQLLIAWANNAIKTYSIDGLRIDAAKHVNTGFLQNFSNGVDTFMTGEVLEGAVSIMEDYQSNYIDSLPNYPIYFEIIDAFTQGNTSQLAKAVENMRITMPDVNAMATFSENHDKPRIGSYSDDIAMAKNVLVFTMLFDGIPMIYQGQEQHLKGNSVPVNREAIWLTKYDTNAVLYQLIAKLNRIRNHAALLGTNYFEDSTHTIYQGASELGFTKGVQGRQVVMVLSTQPSTSGAYNLDMAVTYNAGTVIMDVLNCKNYTVDNQGLLRVDMNKGEPRVFFPTQYMEGSGLCGYSETNVTLAMLETGSSSTSAGMQFTSGTGVAALLLAVMTSMFVMLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q306</accession>
    <name>W6Q306_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type DNA-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PROQFM164_S02g000855</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q306"/>
    <dbReference type="STRING" id="1365484.W6Q306"/>
    <dbReference type="OMA" id="YAHTFAQ"/>
    <dbReference type="OrthoDB" id="10250282at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47431:SF5">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47431">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="36"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="67"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM30705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="718" mass="79309" checksum="766F62433ADEB9FE" modified="2014-04-16" version="1">MLGVVMAATFQDYNGLASTAPRSVRKKFAKPPVKVACLPCRASRTRCGGQMPCTNCVSKDRECSYLPSKRGGPRKKKEKSSLSPEQESRQDDALYNSVPSPPEFEEAPGMFSQIDELSLPGAGLRHLDFQSEIPSMFQSFFTGDGSQSHMQVPLISSPSNNAQTFVRTYGSELEILNAYYDFIHNYFPILPPRASPPCRDRPLNCSVPCSNTSEPMMMYRPRSPLSLAISAILALIPHPSDIEPSSAASVIQRRTYAHTFAQLAHSTIEAECDLDLSSTDPGQALSAARPFVGRERFHSQTPVDYESLLALLVLSVYEYSQRGNLLKMRYRAGQALAIALDKSLHAQLENDESSEARRRAWWMTYYCVVQGSIVSTTMPAIVINDPQFTTPYPSFSSDTEGWAIFIQAQQVLVSATQFIGDLNKCIASQSGMYYMFERMQQLDAWTQSVIAQAELLPLLPQTSDFGDHNESITAQSIRAISRIKLSSAQIKTHRFRAFSDIPLFIKRHCDLTAANPNSATTIVSTKPAGINNITCSCSNLTSLERATSTEYMTPSDSSTSSDINPEISSYAPQYSQYPFAAGFPYSTQQSAKICLQAALVISRMFHNLPVPQPLSDPQQQQGRSLPRTMPSFACCLMQSSYAMFMIYYKARVAKQLAPDTAENEQGGDSTGQLIEELRQGLERIIGAVSNYSLAFEALDGMRDEIEGAYKTAFPLASV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q366</accession>
    <name>W6Q366_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Reverse transcriptase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S01g002445</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q366"/>
    <dbReference type="STRING" id="1365484.W6Q366"/>
    <dbReference type="OMA" id="WNSYFAR"/>
    <dbReference type="OrthoDB" id="74545at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01709">
        <property type="entry name" value="RT_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37015">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37015:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM28634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="909" mass="104273" checksum="33F84494072C8E32" modified="2014-04-16" version="1">MTTNGALPQTLKSITATKINELSKQRALFDRRKARILEVANEAPDLRTRAQALLYGLTRLKGYPKDLLDEHDLDLDADPSPEESEDKVIIWRVGRLQPGDHTSIHRFLLQSRYDPSISPAAIQDRVDQLEKELQYLEKKHEHSAFYSNLVTEWLSDLDGSIISKSTSSGSSSGSSSDNIARAEMPEQRATWESLTFTAATHVNEDAIRSYLDDLFTQTNLSRQALMDLRASIQSFGTELSSKNNWFNVEELKWVSRALLKSDLLSDEKTSILKEFMRNNEVAQEVADVLNMRISSLDSWTWSGAADGVSVEMRRQLNGKYRFFMDEDLLDALLLQYLGTKWAVKLRTVFETFLHSNAWKPLNEDIPDDHKEMRKYFLGRDANLGAVNLNEIRRMTYADQYFMSQLPTSTAEGAREYDDTTNSSPENPMDKKHSLLHLLITESIIHKRQRGDFTAIRSDFEWFGPSIPHATMLTVLEFFGVSELWIKFFVVFLEAPLKFAQDGAEGSVQIRKRGVPMSHTLSDCFGESVLFCMDYAVNQATDGAFLYRLHDDFWFWGAENTCVKAWGAMDQFTQVMGLKFNQEKTGTVQMGLNKTPKDSALPTGDIRWGFLVLDAEKERFIIDQTQVDQHIEELLRQLSACKSVFAWVQAWNSYFGRFFTNNFAKPATCFGRDHIDMAISTLSRIERTLFNKISDDKSSSNQISGVTDYLRTVIADRFDIHDLPDGFFYYPVELGGLGLLNPFVRLLAMRENMKQTPQKLFHKASLMEEKEYEGDKEEFKRNGADVSIPFSSKWGVESTSFMSLEDYTRYPETFSSSFVRVYRQLAEVPDEMSVDPTWSLVREQKCLDQRSSEGSINAFWNTMTPYWKWVAEFYHEGMVRTYGSLDAVNRQSMPLGVVKTLREGKFRWQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q3Z6</accession>
    <name>W6Q3Z6_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S02g001463</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1365484.W6Q3Z6"/>
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    <dbReference type="OrthoDB" id="5419922at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="545"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="654"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="733"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="785"/>
            <end position="809"/>
        </location>
    </feature>
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        <location>
            <begin position="112"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="220"/>
        </location>
    </feature>
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        <location>
            <begin position="235"/>
            <end position="246"/>
        </location>
    </feature>
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        <location>
            <begin position="286"/>
            <end position="296"/>
        </location>
    </feature>
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        <location>
            <begin position="367"/>
            <end position="400"/>
        </location>
    </feature>
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        <location>
            <begin position="414"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="433"/>
            <end position="443"/>
        </location>
    </feature>
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            <begin position="444"/>
            <end position="456"/>
        </location>
    </feature>
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        <location>
            <begin position="469"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="549"/>
            <end position="563"/>
        </location>
    </feature>
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        <location>
            <begin position="684"/>
            <end position="695"/>
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            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="785"/>
            <end position="794"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM31313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="809" mass="89295" checksum="73F51B54F16A8695" modified="2014-04-16" version="1">MPYPRPVSPVSLEICPHSSSEIDSDDLVASDDELDDAARAAKRQRVEKLAESYLQGKPLFILSSSLRGPLDNGWANPWKKNRTRGTGAAVKARQKNVPEPVVLETDLQAPKYRKDLSVGTRRPDIPATSWNSPRISVQIGDRSSPSKSPRRHPKEPIPRSGHTAQNRATADWLKKDRKLMNFTRFEPPSSPTISVASRQSDKAGRLAPRSVQVQVPQTPASPEKCHPVKPVLAKTAQSARVNSNEHVSLRSIRATLNSPKDPTVPSHLPREPSLRIVDSSSQLPRFEYRRWPRERSSQQLKTSPMRDESILQEETFIQEDSPLKEKSIVDLEPASPSPAKDQALDPAEPEPEPEPEQPQPRPRTETETETETESEPEPEPEPEPEPEPEPEPEPELELEFEPSVPEEIPVQNEDSIKKDASHKTLSKETRFADEDDLIEDNLGVEEAAAEGAADAEAVAEDVTTEKDISTFQNTDHSGSTEHNTYDDLPSAQQVPPPLGVSDRVTSLHSTALARVDPGQDSPQSPDTQLSTLAALLHAQRSFQDDLDSPEFHAETPDSDRAVHSPDASLRSANVTPFYRLEESIRRDLERSSISKNKDGMHAMSTQFMLDAATPFNFSTEQAGQDRSLKPTNRNMTQAMNTQFMLDAATPYAFSTEKRQRTSRPDSGSPTARGSKRKRTANIGSPSPSIRSQSTSVDNEYHTAESQSSEDDESSRSVAEQLDHQLTYQSPTEAASLPLTLSESVPTTGQDGQGVRQGMESFNLSQAIADAGSWLQQSFDFMSSARPSRSFNAIPTSDARPSPLNMDVSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q508</accession>
    <name>W6Q508_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q508"/>
    <dbReference type="STRING" id="1365484.W6Q508"/>
    <dbReference type="OMA" id="NDTRPRM"/>
    <dbReference type="OrthoDB" id="4201296at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM31066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="82" mass="9443" checksum="88EA5AC4947AFC85" modified="2014-04-16" version="1">MRDTPSKFIEILDPKDSRRMSDADVRLEDVLADHEATINNRARSSTQTSTKPEKSPSRRNSTSPTPRWKRLSNILAQPRRHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q514</accession>
    <name>W6Q514_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Chitin-binding, type 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PROQFM164_S02g001585</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
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            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
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        <property type="protein sequence ID" value="CDM31435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd11618">
        <property type="entry name" value="ChtBD1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Endochitinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001002">
        <property type="entry name" value="Chitin-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036861">
        <property type="entry name" value="Endochitinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052210">
        <property type="entry name" value="LysM1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34997">
        <property type="entry name" value="AM15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34997:SF1">
        <property type="entry name" value="PEPTIDOGLYCAN-BINDING LYSIN DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57016">
        <property type="entry name" value="Plant lectins/antimicrobial peptides"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CHIT_BIND_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="LYSM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004879912" evidence="5">
        <location>
            <begin position="24"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="7">
        <location>
            <begin position="228"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="7">
        <location>
            <begin position="367"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-1" evidence="6">
        <location>
            <begin position="584"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="551"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="557"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="604"/>
            <end position="618"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM31435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="631" mass="66629" checksum="1AAA77D0F70787BD" modified="2014-04-16" version="1">MALLRASAALAVVLMLQSHHAAAWGNSDTLYIYNSDTLADISASEACVNAMSSNVSCYAGLSQAVTQTTSWSANALSEMCTSGCSSALSSYVSSVDEACGTSTQYNISGISQTASDRGKEMKWRYDATCLTDSASGTYCNTLFQNAISNGTTNIKCSACYLEYLSTLVNSKWGQDILLSPSALTSQVSSCSTSGYSVTYTRTSTASSTASASATVAASRCNTTDPDQTVYKVESGDTCLSISAAQNVSTSALINLNSLDTGCTHIVAGAEICLPDVCEIYRVQETDTIDKIVASLSRQVSVPQFVAWNANLNSAQSSQNLTAVSGKYICVSPPGTLTLPDTLALRPASTAVSLPTDAVASSNTDCGHWYQVQDGDTCESVCDKFSISQYNFNFLNPQAALNATSSCGSLWKGNSYCVQAVGNINTYTSYISNTTRTRTSLASTMNLNATRTANHSTTNLFWSFPSDLTTASTWTPDSAYLASLATYTLCDQVNSVYNITDDDLTDEMYHDEVWLSEYERVCYPPVNGSFPTTGFNFSITLTDDPSMGSSTVFTSSQTASPHASSTVTTATSTTVATPTSTISENGLCGPSNSDWTCLGSQFGDCCSNYGYCGSSSEYCSSANCNAKYGSCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q6J0</accession>
    <name>W6Q6J0_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">2-dehydropantoate 2-reductase</fullName>
            <ecNumber evidence="2">1.1.1.169</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Ketopantoate reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PROQFM164_S02g002464</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ketopantoate reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.169" evidence="2"/>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q6J0"/>
    <dbReference type="STRING" id="1365484.W6Q6J0"/>
    <dbReference type="OMA" id="RKEPFQV"/>
    <dbReference type="OrthoDB" id="73846at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008677">
        <property type="term" value="F:2-dehydropantoate 2-reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000038">
        <property type="entry name" value="Probable 2-dehydropantoate 2-reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003710">
        <property type="entry name" value="ApbA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050838">
        <property type="entry name" value="Ketopantoate_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013752">
        <property type="entry name" value="KPA_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013332">
        <property type="entry name" value="KPR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00745">
        <property type="entry name" value="apbA_panE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43765:SF2">
        <property type="entry name" value="2-DEHYDROPANTOATE 2-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43765">
        <property type="entry name" value="2-DEHYDROPANTOATE 2-REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02558">
        <property type="entry name" value="ApbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08546">
        <property type="entry name" value="ApbA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketopantoate reductase N-terminal" evidence="7">
        <location>
            <begin position="57"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="Ketopantoate reductase C-terminal" evidence="8">
        <location>
            <begin position="281"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM32313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="438" mass="48857" checksum="BBF4D55BBA81FFDF" modified="2014-04-16" version="1">MQSTFRPRTLWRTGILGTCVRSRFQVYGVPNTRFISTWREELHEVNQDTKAPLSGRVHILGMGNLGCFFAHSLATRRSPPPITICLHNDYLYQAFVRKRGQISVSTHGLDDVRTGFDVETVDEEGRWYTMPPVDNRPSPFNPQSPPDSGPIECLIICTKAHHTELAIKDISHRLTKDSTICLVHNGMGVLDSINQNVFPDPNNRPHYIQAVFSHGLGRNDSFKISHLGVGTTILSPVGDPSIPPTNPEADQTWAPSTKYLLRLLTLTPPLVAVADTPAGLLQYQLEKLAVNCVINPLTALSDCTNGEILYSFSFTRVMRLLLFEISAVICALPELQGIPGIEDRFSPERLRRLVVNIASNTAKNHSSMQQDINQRRLTEIEYFNGWIVRRGEELGIKCALNYMIKHLVAAKAATHRSREAGAIPLDLDNVISTNEPPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q6V7</accession>
    <name>W6Q6V7_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">DNA replication complex GINS protein PSF2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">psf2</name>
        <name evidence="13" type="ORF">PROQFM164_S02g001872</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">The GINS complex plays an essential role in the initiation of DNA replication. Has a role in chromosome segregation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the GINS complex which is a heterotetramer of SLD5, PSF1, PSF2 and PSF3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the GINS2/PSF2 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q6V7"/>
    <dbReference type="STRING" id="1365484.W6Q6V7"/>
    <dbReference type="OMA" id="DSLNCMY"/>
    <dbReference type="OrthoDB" id="1938138at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000811">
        <property type="term" value="C:GINS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11712">
        <property type="entry name" value="GINS_A_psf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21694">
        <property type="entry name" value="GINS_B_Psf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1020:FF:000001">
        <property type="entry name" value="DNA replication complex GINS protein PSF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.5.50:FF:000001">
        <property type="entry name" value="DNA replication complex GINS protein PSF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.5.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021151">
        <property type="entry name" value="GINS_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036224">
        <property type="entry name" value="GINS_bundle-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007257">
        <property type="entry name" value="GINS_Psf2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056784">
        <property type="entry name" value="PSF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12772">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN PSF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12772:SF0">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN PSF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25005">
        <property type="entry name" value="PSF2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05916">
        <property type="entry name" value="Sld5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028998">
        <property type="entry name" value="GINS_Psf2_subgr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158573">
        <property type="entry name" value="GINS helical bundle-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160059">
        <property type="entry name" value="PriA/YqbF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="5 9" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA replication complex GINS protein PSF2 N-terminal" evidence="12">
        <location>
            <begin position="10"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="GINS subunit" evidence="11">
        <location>
            <begin position="148"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="92"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="237"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="260"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR028998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF25005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDM31721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="271" mass="29923" checksum="DE37FF051FFC5F25" modified="2014-04-16" version="1">MAFPLPRGVTASEIAFLAEMETVTIVPRQRLEGLELLGGPIEPLVPPRRASLPLWLAILLKRQRRANIIPPTWLHPEPLALILEVESQHQDYKNAFSPPPPLPGQPSVLDRDALPSARPQYTPDGNRYYAAPPFLPQNTAQTVASSRDPPSLPYHWVEVGNMLLDAASDDLVDPDQIRRLLKDLREVRMAKMRSGVDVLDAAATGGGGVALTGVGSMELGEERGFVTGVVDGLRRIGSSKEQARREQMAEQRANGAYDDTRDEDEEDYMEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q7C9</accession>
    <name>W6Q7C9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S02g002037</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q7C9"/>
    <dbReference type="STRING" id="1365484.W6Q7C9"/>
    <dbReference type="OMA" id="DPWAWQN"/>
    <dbReference type="OrthoDB" id="2937326at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056121">
        <property type="entry name" value="DUF7704"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37019">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37019:SF2">
        <property type="entry name" value="EXPERA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24803">
        <property type="entry name" value="DUF7704"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7704" evidence="2">
        <location>
            <begin position="3"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM31886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="156" mass="16831" checksum="C99C01D15717A163" modified="2014-04-16" version="1">MPTIFPLWPHILFGVLEPISLALGSAYPIYNLQGFIAGQTPNIAAPATLHPSSVALAYQLGNVYSLLFLVGVGVCHATTEPRVLRNYLIGLAIADIGHVYATYLAMGWDAFADVAAWNALTWGNIGVTMFLFVNRIAYFLGIFGYAKAPKAAAKRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q854</accession>
    <name>W6Q854_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Major facilitator superfamily domain, general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PROQFM164_S02g003039</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q854"/>
    <dbReference type="OMA" id="CYSATWS"/>
    <dbReference type="OrthoDB" id="2213137at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF287">
        <property type="entry name" value="MFS MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="44"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="87"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="207"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="246"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="284"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="314"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="341"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="375"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="417"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="4">
        <location>
            <begin position="250"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDM32888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="444" mass="48597" checksum="1E9D050826BEACFF" modified="2014-04-16" version="1">MERRRPSCSDSLPRSEAQIRLFPEKFDESSTDDRQKLPPVDGGFQAWMFLMACVMLEALIWGFAFAFGVFQKYYHAHEAFQDSNMVAVVGTCATGISYLSCPLVIIAMILLPQWGRWFSSIGVIIMCLSLALGSFSSNITHLVLSQGVGFGIGGCIAYSPSILYMDEWFVHRRGLAFGITWAGSGVSGIIFPIGLEKLLNRYGFETTLRVISVVVFVLAAPFIYFHKPRLPVRKTVDYQRLNFRFLTSRIFCVYQLGNIMEALGFFLPGIYLPTYARSIGASDFLSSLTITLLNLASVFGSVTMGHLADRYHAVTCITISTVGSTLAVFFLWGFATTLPTLFVFSIAYGLFAGCYSATWSGITHEVRRIDPSADATIIFSVIAFGRGIGNVVSGPLSEAILEVDPWKGSAAAGYGSGYGLIILCTGISCLLSGVCIVAHYMRCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q8U7</accession>
    <name>W6Q8U7_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DNA mismatch repair protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PROQFM164_S02g003244</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutL/HexB family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM33093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q8U7"/>
    <dbReference type="STRING" id="1365484.W6Q8U7"/>
    <dbReference type="OMA" id="YAIAQPS"/>
    <dbReference type="OrthoDB" id="10263226at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032389">
        <property type="term" value="C:MutLalpha complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061982">
        <property type="term" value="P:meiosis I cell cycle process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000017">
        <property type="entry name" value="PMS1 homolog 1, mismatch repair system component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014762">
        <property type="entry name" value="DNA_mismatch_repair_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013507">
        <property type="entry name" value="DNA_mismatch_S5_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002099">
        <property type="entry name" value="MutL/Mlh/PMS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038973">
        <property type="entry name" value="MutL/Mlh/Pms-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00585">
        <property type="entry name" value="mutl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073:SF41">
        <property type="entry name" value="MISMATCH REPAIR PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G05820)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01119">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13589">
        <property type="entry name" value="HATPase_c_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01340">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00058">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histidine kinase/HSP90-like ATPase" evidence="4">
        <location>
            <begin position="18"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="DNA mismatch repair protein S5" evidence="5">
        <location>
            <begin position="219"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="347"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="380"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="438"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="608"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="348"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="413"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="438"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="474"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="502"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="520"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="538"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDM33093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="803" mass="88329" checksum="1B5AFADFE7DA9FE9" modified="2014-04-16" version="1">MTIEALPQKTIRAIGSTSAISDPCSVVKELVDNALDASATSLQVEISQNTVDVIQLKDNGHGISPEDQQNVCKRAFTSKIQSLDDLKNVGGSSLGFRGEALASVAEMSGLVTVTTRVESEVAGRCLKYGRNGELTGTQRTSHPVGTTVRIAEFLKHIPVRRQTILKGAAKSLTKIKKLLQAYAIAQPLKRFSFKVLKTKGENSNWVYVPSADASLSDAVLKIAGTEVFSSCVLKEKSDQTGYEAAAFLPKNIQLDTAKINNAGQFISVDGRPLSNSRGVAHEIVKNFKQHLRVVLKESSDPFLCLQIRCPRGTYDVNIEPGKDNILFEDQDIVLALVENMFRDHYGTETRNSTQGKENSCKPNESSGGFELLLARKPAELAAHPGDPDNPFSLATPCTPLSQNPQALSPPVPSSTVRSKQPSFVNPWSVSRINASFQTPRRGNNYLNQTSPVDLSSGSLQEPIQREGEPRVVQHSPNSAPISPLTSRLASGSPVKRRRQHPQESTECSPETNRISSARRAQRERDRDRYGNGALDTWFQRTTQVSLQKSPTEEAPTQEPDSPLSFLTQQRFGLPTNNLPDIMHIDGQNDGCSDSPDLEKALDFERRKKEAIQNSRMRVSDNEKTSSSQSAPEFHSPHKSRYLAAKAALTSSQASVSEPVSATTLSPRDPRAYLIRQARDHSTDETFTKDGKAKRLPTNRLPFERIPDGSDLHDLGLTLSVDLSSGSNLFKCNISENLYTENDNETTAFSTPDLETCVPFWNEQLMLLMKQKYKNMDQSKPLNMHIDLATIISPHVQIAQSNSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q8X4</accession>
    <name>W6Q8X4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AMP-dependent synthetase/ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PROQFM164_S02g003270</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the NRP synthetase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM33118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q8X4"/>
    <dbReference type="STRING" id="1365484.W6Q8X4"/>
    <dbReference type="OMA" id="VAPYSSH"/>
    <dbReference type="OrthoDB" id="408177at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05930">
        <property type="entry name" value="A_NRPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05235">
        <property type="entry name" value="SDR_e1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.980">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.38.10">
        <property type="entry name" value="Luciferase, Domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010080">
        <property type="entry name" value="Thioester_reductase-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01746">
        <property type="entry name" value="Thioester-redct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44845:SF6">
        <property type="entry name" value="BETA-ALANINE-ACTIVATING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44845">
        <property type="entry name" value="CARRIER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01294">
        <property type="entry name" value="PKS_PP_betabranch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="4">
        <location>
            <begin position="556"/>
            <end position="633"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDM33118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="1051" mass="116100" checksum="A627495AD0ACA444" modified="2014-04-16" version="1">MYDKSIDIIRPGALAHGSSVSEYTTPVFPIQHCGGRTSPEGMGLAGLLQQQIRKNGAVTAIQDSTDRLSYAELHQKALALAIQIQAGNPGDTSPVGIIIPRGLNHVLGQVAVIYAGRVCVPLDEKLPDSHLASMLENLKSALVLTNATHQHRLPTFRHTLVDHSKVPLMAVDSFHPVFRSAWTSSHILHTSGTTGKPKAVDSMAEGLINLSFDSSDFVRHGQRVGHGASVHFDSALVEIWTTLLRGATVVVIPAETVLDPMALRAFVKTEKLNVLQLTTSLLTVTAFACSDAFSTLDTLLTGGEAINCDIIRLIFDNGAPRRIINGYGPTECSIYTLWHVISQNEALRGEIPVGKPIGNLETFLVNEKGHLAQPGEVGELLVGGPGVARGYIGNPEKTAQSFVTMPQLKSQTTRGIGHVYRTGDLMRTDENGVHFYLGRKDNQVKIRGQRVELEALEASLLETRLVSAAVVIKITPDEVERGQFLLAFCIPTTHESTEGAILRAYISQFPHLMVPRIQLISDLPLSSTGKADRRALERQWYEQIERSRDFAAALEIDSDDVAVQVERIWLDVCSLPAEHLVPTADFVALGGSSIVAVMMITRINQALGVSMQARMLYENSTFEQLVQLVTRLQLNGDDLSAQSEQEIWLQDAQLGQFLRPQDTTIPHWQSPDEGRVFLTGATGFIGIFLLDALVKRPEVVQVACLVRAQDETTALRRIQETGRKYGLFLDLRKVIAVPGDFSLAKLGLDTTQYDHWASWASVVFHLGAKVSYVAPYSSHRQVNVIGTLFMLEFAKHQRLKAMHYSSSIAAYGPTGYVTGATMLPEDERPAPHLAAMQYDTGYSQSQYVAEMIVWSAIDNGFPVSIYRPGFVLGHSKSGLCNPDDFVSRLFTSCISLGLFPILPNQRKEFIPVDFIVNAILHISTSHNNFGHAYNLIQPDLTNAIDINTSFEILKRISRYPLRGVSYTDWVKSLSRRPDDPLHPLTPMLKEAVLGDKTRWEVYENMAEYGRANLRRALQDAPDILNCDPIEVIFERCLKTWVCQVESGLKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2024-10-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q8Z0</accession>
    <name>W6Q8Z0_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S01g000031</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q8Z0"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM26222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="72" mass="8051" checksum="D8FD576ADC5B3A25" modified="2014-04-16" version="1">MSIPGVHQYHVHLYIRRKNRHKPSLKAQDVAIFEPNKGIARHGLALKLADAFFSICEDPSGGEDAKLTDDEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q9I3</accession>
    <name>W6Q9I3_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S03</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S03g000007</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q9I3"/>
    <dbReference type="OrthoDB" id="4266429at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM33283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="128" mass="13935" checksum="311AA4838E642408" modified="2014-04-16" version="1">MDAKSQDNPDSGNISVVVNGSIHAHPAKTAMVHPIPIQVNAKSISPSIKEIPRGQDEETPSSTIGCREKSNGIKHKPQTTYTLKDCEFDGESMLSNGSARSTSELQFYRNPKSGQAFFVHGDMDIDTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2024-10-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q9R2</accession>
    <name>W6Q9R2_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S01g000321</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q9R2"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM26512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="56" mass="5890" checksum="F458C51338949F2A" modified="2014-04-16" version="1">MQGIIYSSADSESSPVVGTVREAVAERGGGLLLLERGQIGGRCLKGIRFVRDSPEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W6QA74</accession>
    <name>W6QA74_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Small GTPase superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PROQFM164_S02g001224</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QA74"/>
    <dbReference type="SMR" id="W6QA74"/>
    <dbReference type="STRING" id="1365484.W6QA74"/>
    <dbReference type="OMA" id="PVSNDGC"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01861">
        <property type="entry name" value="Rab6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000229">
        <property type="entry name" value="Probable Ras-related protein Rab-6A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050227">
        <property type="entry name" value="Rab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47977">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0636">Prenylation</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM31074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="209" mass="23327" checksum="A14AF49B2EE545A1" modified="2014-04-16" version="1">MASTSGVGSYSNPLKKFKLVFLGEQSVGKTSLITRFMYDSFDNTYQATIGIDFLSKTMYLEDRTVRLQLWDTAGQERFRSLIPSYIRDSSVAVVVYDISNAKSFQNTRKWIDDVRGERGNDVIIVLVGNKTDLNDKREVTTAQGEEEAKKNGLMFIETSAKVGHNVKQLFRRIAQALPGMEGEAKQGESTMIDVNINPKETTSNDGCAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2024-10-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>W6QAC2</accession>
    <name>W6QAC2_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S03</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S03g000342</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QAC2"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM33618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="81" mass="9109" checksum="F6BE3C5A86EEBA40" modified="2014-04-16" version="1">MKPDVDKGGKTSTYPRTLKVAPAIWMRVYHILPKPGSIAERVIENDLLRSASMMALGFTSFLARCRIIRKHVKSSVEGHNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W6QAM0</accession>
    <name>W6QAM0_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phospho-2-dehydro-3-deoxyheptonate aldolase</fullName>
            <ecNumber evidence="6">2.5.1.54</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">aro-8</name>
        <name evidence="7" type="ORF">PROQFM164_S03g000452</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4 6">
            <text>D-erythrose 4-phosphate + phosphoenolpyruvate + H2O = 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14717"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16897"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="2.5.1.54"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="5">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="5">
            <name>Cd(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48775"/>
        </cofactor>
        <text evidence="5">Binds 1 divalent cation per subunit. The enzyme is active with manganese, cobalt or cadmium ions.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 1/7.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the class-II DAHP synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.54" evidence="6"/>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QAM0"/>
    <dbReference type="STRING" id="1365484.W6QAM0"/>
    <dbReference type="OMA" id="FKVMMQM"/>
    <dbReference type="OrthoDB" id="2338at2759"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00084"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003849">
        <property type="term" value="F:3-deoxy-7-phosphoheptulonate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002480">
        <property type="entry name" value="DAHP_synth_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21337:SF0">
        <property type="entry name" value="PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21337">
        <property type="entry name" value="PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATE ALDOLASE 1, 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01474">
        <property type="entry name" value="DAHP_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0104">Cadmium</keyword>
    <keyword evidence="5" id="KW-0170">Cobalt</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="330"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="362"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="404"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="434"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602480-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM33728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="459" mass="50192" checksum="154B18D85C3E9D83" modified="2014-04-16" version="1">MAEWSPSSWTQKPIKQDVIYEDAQGLQDSLQKLQKLPPLVTTQEIINLKKNLRNVALGKAFVLQGGDCAELFDYCSQEMIEAKVKLLLQMSLVLIWGANKPVIRIARIAGQFAKPRSSPTEVINGVEMPSFRGDNINGFAADPVSRQPDPSRLVSAYFHSAATLNYLRASLSSGLADLHSPLDWGLGHVITPSIKEQYAKTVRAVKDALRFMHTVGIDKDRGFETADIFTSHEGLSLEYEQSLTRLLRHPARPGSTTTAPETGYYATSGHFLWIGDRTRQLGGAHIEFFRGIANPVGIKIGPSMAADELVQLLDVVNPDREVGKVTLISRYGAGKIATFLPGHIAAVQASGHIPVWQCDPMHGNTQSTPSGVKTRHFTDILSELKQALEIHRAAGSFLGGMHLELTGEAVTECVGGAGGLTEDGLGERYTTFCDPRLNEKQALELAFLVAGFYREESEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W6QB39</accession>
    <name>W6QB39_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S02g001499</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QB39"/>
    <dbReference type="STRING" id="1365484.W6QB39"/>
    <dbReference type="OMA" id="LHCDNCQ"/>
    <dbReference type="OrthoDB" id="438080at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007175">
        <property type="entry name" value="Rpr2/Snm1/Rpp21"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04032">
        <property type="entry name" value="Rpr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM31349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="180" mass="19363" checksum="52CF6D790B60CF40" modified="2014-04-16" version="1">MSHIDPSFLIQAVSAIPLGSSTSAHLLAVHTRLLHEESKSLNAQQKRDHCGACGSIRKPQWSKVTEIKPKKSKPLASGSASTGATVYKCLRCCQRTVLPQRNSRNHISKPSSRAATVTTRGSTPMRVDVQGSTPASTDPKAGDNQSSKKRAKARKQGGLQALLASKQRAQPSLDLLDFLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W6QB52</accession>
    <name>W6QB52_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S01g000746</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QB52"/>
    <dbReference type="OMA" id="NELTCSC"/>
    <dbReference type="OrthoDB" id="4348245at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM26937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="184" mass="20683" checksum="D0F3989CCAD7A854" modified="2014-04-16" version="1">MDATTLQAAREFFADSRDDFVVYIQELSAGDISDQGAAAIQTELRRIAHTLSGWMELRDDPNGMSCSYFSERCCNLSDIVVEVAEMVTIKDGQLPPTVMKMFGMLAIHLGRLNLNGHREEDKYARGFDRMAKDEDRRWQIGSQGPDDGRAELLLGLWTRMNRISEPGPNCTFECLRAHAGSHIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2024-10-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>W6QBB1</accession>
    <name>W6QBB1_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S01g000796</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QBB1"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM26987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="60" mass="6695" checksum="3A2B53B157094325" modified="2014-04-16" version="1">MKWRILENRVLGNPLESRPSVFSRLDSAKLGWRTLSSVRGDPDDCAECSPSVTSGFRISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W6QBC7</accession>
    <name>W6QBC7_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PROQFM164_S02g001609</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QBC7"/>
    <dbReference type="STRING" id="1365484.W6QBC7"/>
    <dbReference type="ESTHER" id="penro-w6qbc7">
        <property type="family name" value="Fungal_carboxylesterase_lipase"/>
    </dbReference>
    <dbReference type="OMA" id="DQPPWCP"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000266">
        <property type="entry name" value="Carboxylic ester hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005151060" description="Carboxylic ester hydrolase" evidence="3">
        <location>
            <begin position="24"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="30"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDM31459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="599" mass="64689" checksum="68E3E2DDD24B63B8" modified="2014-04-16" version="1">MGFAAGISSLVFLALTTAPAGLATPVQTSSPVVDLDYATYQGYYDNTYDLNVFKGIRYAAPPVGKLRWQPPQSPAVNKTSIQSATEQPPLCPQSGAAQLPELYGFGSALGNEDCLFLNLYAPPGAKDLPVLLWIHGGGYGLFGAEYDPSEWIATNENGFIAVMIQYRLGAFGFLSSEGVHKYGKANAGLLDMRFALEWVQENIEKFGGNASRVTIAGESSGAGSVLLQSIAYGGREDHLFNNVIAASPYTTDLHQYDGKVPTGHYQDFAARAGCYNGGNVSEAAVFDCLVNADTDTLQYASANVSISGAWGTWAFLPVVDGDFIQELPSKQLYTKKVSGKRVLSGNNANEGVPLSPPFVNTTASFLSYVKSTFPLFSRSDYSRLLDIYGFRNSSPQDTAPRYDTLGDHGQNALNQSEMATGLQQTVFDIYAESAFDCPSYWLADAFAGKNTTESWKYQYSVTPGYHGADLSAYFSVGATTPTPGLIHAFQKIWGNFIINDTPIISIVDAKGGADNSTVPECANGDISWPRWNSNSPVLMNLNTTGGTTVYEKVTDNLSYWIREGPGVTNEFSLADASKWEGGRGERCEFWRSVGPRVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W6QBN1</accession>
    <name>W6QBN1_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Dilute</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S03g000584</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QBN1"/>
    <dbReference type="STRING" id="1365484.W6QBN1"/>
    <dbReference type="OMA" id="WSQVMYW"/>
    <dbReference type="OrthoDB" id="426293at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051020">
        <property type="term" value="F:GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15473">
        <property type="entry name" value="Myo5p-like_CBD_DIL_ANK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002710">
        <property type="entry name" value="Dilute_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037986">
        <property type="entry name" value="Myo5p-like_CBD_DIL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052072">
        <property type="entry name" value="Vascular_dev_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16027:SF6">
        <property type="entry name" value="DILUTE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16027">
        <property type="entry name" value="DILUTE DOMAIN-CONTAINING PROTEIN YPR089W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01843">
        <property type="entry name" value="DIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01132">
        <property type="entry name" value="DIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51126">
        <property type="entry name" value="DILUTE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="185"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="218"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="Dilute" evidence="3">
        <location>
            <begin position="411"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="513"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="727"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="30"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="516"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="744"/>
            <end position="754"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM33860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="839" mass="94653" checksum="B361FA23ECE2E4CD" modified="2014-04-16" version="1">MVDMTESRRGASEDPIDSNDYSDHSPASFHEAKQELPDDLPRSLDDRRSVPVFQPETEMYDAWQGQSQYLTAPVAAKPLSFSLALDDHSHDNEHELRAQYGRDIEDNDARLMEMLAAQAAHREVDSLTADEETIAADEKLSDDEKRDILQKSLNMAASNGDVDRVRKLVQGEARTYVDVNKPDEEGTVPLIYASCFGHQDVVAALIAAGALVDRQDRNQWSALMWAMTNRHKTIAKILLDNGASPDIKSSSGGRAFDFAQPGSEISEYLHENGYNFGSGNIDDDFYDAGLAHGRFEEELAESEMKRRMMMEESAINLEVDLSSLGLDEKFEPFDEDELEEDQQEFVWDKCLNDQMFVFQDHELERILDIIITNMTPQRSPSQKPVPANLLFLSARYAHYHASPELLATLLSSAMEKINDVVERYQWDMTMQAFWLSNATLLLHYLKKDGGLAESTVEFQLHLAELINEIFVLIIRDAERRMNKVLDAAMLDHETIPGLEDVAFQNEWKLFRKNKSKNPEPDEKRFRPPSPRRRAQISPRNITSLLSSTLFVLDLYDVHSVITTQVLSQLLYWLSAEIFNRIMSTKRYLARTKAMQIRMNVSSLEDWARTNNRVPEHYENGSTNSTGESTIDAARRHLAPVIQLLQWLQCFSSLGDDHESLVTTLLQLQQLTPAQLLHAVKSYRPEVGEKGLTKQAMKFLLDMQNDPEVLYREQQEIQEDRARVAAGLGPQAAADARPNTPPKNQPSAAPTSPDTRLSPGPAAESSRPTSMVATRNEERPGSGNSVFVDPTLFLPFSLPTSTDMLVSYGAGFGGTNRERARKYIPTVPPEVLSRFDRGDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W6QCU2</accession>
    <name>W6QCU2_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g001233</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QCU2"/>
    <dbReference type="STRING" id="1365484.W6QCU2"/>
    <dbReference type="OMA" id="TKKYIWR"/>
    <dbReference type="OrthoDB" id="66881at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045632">
        <property type="entry name" value="DUF6314"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19834">
        <property type="entry name" value="DUF6314"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6314" evidence="1">
        <location>
            <begin position="23"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6314" evidence="1">
        <location>
            <begin position="164"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM27422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="219" mass="24172" checksum="BD8CEEC90BCA36D0" modified="2014-04-16" version="1">MPTMPTMPSRQLLSTLITSLTNTRWTLTRTLRSENPLDLNGELRGTATFTPQPPTTTADRDWLYCEEGEIPSNVGGPLPAGLRWTKKYIWRLGSDSGHVSVWFVKVASGPEEADYLFHDFDFDSGSSSPLGSESGSAQKDPGEFVAPPVPPAVSTPGNEMETTVLNARGNHLCINDMYRTAYAFRIEPDTGEVLSWASRHVVRGPKKGQDIVNRYEKEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2024-10-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>W6QDE1</accession>
    <name>W6QDE1_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S01g001428</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QDE1"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM27617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="119" mass="13797" checksum="A0DF755E493F39E8" modified="2014-04-16" version="1">MYNIRSAIRVMFFESQAKCGKQCKERLQRIHLSTLRQHCMAVTEAPVASLPGRARERMHLLLEMCQMCHGHVHLDCMQEPNPVQQRMYDEVELELIGALPLAPLNNVFEEISEGWNYTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W6QDH1</accession>
    <name>W6QDH1_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Acyl-CoA N-acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S03g000835</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QDH1"/>
    <dbReference type="STRING" id="1365484.W6QDH1"/>
    <dbReference type="OMA" id="RMNLHLL"/>
    <dbReference type="OrthoDB" id="630895at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43328">
        <property type="entry name" value="ACETYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43328:SF1">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM34111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="261" mass="29662" checksum="1E2A82FE958A3257" modified="2014-04-16" version="1">MVVHFNPLTKEPYLQLPAPCTNIIITPHREYQIEEASAAMTEILNDSRVYSWLQGPPYPFLPEHGIDWVKTKVAENEGVLSTLQREFETQSQQGDGSNSPEELEFFDKCPFICIRKVTERDPATRAPLQDVLIGDISLMRYAFYELQPNSSEFVLAQDQNNDLPVGHKDIVWGIGYYLSPTQHSRGIMSVAVRTVIQDWAIPRMNLHLLRGSFFVGNIGSMKVFEKNNFEEVGTFKDWAPASPNKGRGKMSIVVMKWKGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W6QDJ9</accession>
    <name>W6QDJ9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Bifunctional polymyxin resistance protein, ArnA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S01g001493</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QDJ9"/>
    <dbReference type="STRING" id="1365484.W6QDJ9"/>
    <dbReference type="OMA" id="QGQMKEK"/>
    <dbReference type="OrthoDB" id="2735536at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05227">
        <property type="entry name" value="AR_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000191">
        <property type="entry name" value="Methylglyoxal reductase (NADPH-dependent)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF564">
        <property type="entry name" value="STEROL-4-ALPHA-CARBOXYLATE 3-DEHYDROGENASE, DECARBOXYLATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="3">
        <location>
            <begin position="4"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM27682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="334" mass="37031" checksum="16A3E98B03CC5DBE" modified="2014-04-16" version="1">MVKVLLTGGSGFIAAHIIDILLQHGFDTVVTVRSEEKGKRIIEAHPDVSKEKLSYVIVNDVAKDGAFDEAVKSDPPFDYVLHTASPFHFNVQDPVKDFLDPAIKGTTGILKAIKEYAPTVKRVVITSSFAAIVNGKQHPKVYSEKEWNPVTWEEALDHSQVYRASKTFAEKAAWAFVEKEKPNFDIATINPPLVFGPIVHYLNSLEAINTSNQRIRNLIQGQMKEKIAPTGTFLWVDVRDVALAHVRAIEVPEAGGERFFVTAGFFSNKELADIARETHPELESKLPPADAPSDFPKNIYQIDNSKSQKILGLEYRPLKQTVSDTIDSLLAVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W6QDS3</accession>
    <name>W6QDS3_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SURF1-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PROQFM164_S02g002460</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Probably involved in the biogenesis of the COX complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Mitochondrion inner membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SURF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QDS3"/>
    <dbReference type="STRING" id="1365484.W6QDS3"/>
    <dbReference type="OMA" id="WYSRDVA"/>
    <dbReference type="OrthoDB" id="10040024at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06662">
        <property type="entry name" value="SURF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002994">
        <property type="entry name" value="Surf1/Shy1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045214">
        <property type="entry name" value="Surf1/Surf4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23427">
        <property type="entry name" value="SURFEIT LOCUS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23427:SF2">
        <property type="entry name" value="SURFEIT LOCUS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02104">
        <property type="entry name" value="SURF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50895">
        <property type="entry name" value="SURF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="282"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDM32309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="318" mass="36733" checksum="66439B3239807C2E" modified="2014-04-16" version="1">MRPIFSALQKTSARAWTPPTRALRNPRVPSKINSLCAKYRLHQFRHISQSRQLADGLNIVDHPARLVRVNKKHGPGLIILALIPIISFILGTWQVQRLGWKTKLMAKFEDRLVKPPLPLPPRVDPDAISEFDYRRVYATGHFRHDKEMLVGPRMNEGEDGFIVVTPLEREGQSTVLVNRGWISRKLKDQKDRPLGVPDGEVTVEGLLREPWKKNMFTPDNKPDEGKFYFPDINQMAEKSGSQPVWIEQTMVPDFLESCDREAKGIPIGRAAEVNLRNNHSQYIFTWYGLSLATTIMMWMVVRKNPNEALRRVRQNRNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W6QE28</accession>
    <name>W6QE28_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Major facilitator superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PROQFM164_S03g001000</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QE28"/>
    <dbReference type="STRING" id="1365484.W6QE28"/>
    <dbReference type="OMA" id="SFIGTIC"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033229">
        <property type="term" value="F:cysteine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000064">
        <property type="entry name" value="MFS allantoate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF63">
        <property type="entry name" value="HIGH AFFINITY CYSTEINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="95"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="133"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="163"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="192"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="225"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="254"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="325"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="362"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="389"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="421"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="453"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="485"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="95"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDM34276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="548" mass="62041" checksum="CB83512505ED8F6C" modified="2014-04-16" version="1">MADGRDDPQQGIESVPVEGTEAVNKQHPKIDMGEYENKQDISHVEQVLSASDDLAKDNMDITRVDKEIQAYAAHSQVEIDDATNTRLKRMIDRRILVVMICTYFLQALDKGTMSFSAIMGIKDDAHLKDGQKYSWLTTCIYIAVLIVEYPTNWIIQRVPLGKYLGINICLWGMVLALHSVCKNFTGLVIVRTLLGIFEACCQPIFVTLSSMWYKREEQAATVTYWYMMNGAQQIVGGLLAYCFTLIGADKVLKSWQALFLAYGCISVIWGLFVIWWMPDSPMRAKCFTEEDKRLMVERLRSNQTGIQNRKFHAYQMWEAFCDPQMWCYCAVQIFTTLPTSGLGAFFSIVVLSFNFTVLQTQLLAMVLGAYIIVVLLSSAWLVNRFKQNTIVMLCFIIPSFIGTIVLMTVENTTLPTKVGLLISYYITLSFWSAQTLTLSMVSRNIAGQTKKSTVVAATFVSWAAGNAIGPQVFLDRDAPRYHIAWSVHLACYACMVSAVIYLRFHLKRENAKKDKLLAEAGLSAADPTLIHAFEDKTDRENLNFRYVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W6QET0</accession>
    <name>W6QET0_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type DNA-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PROQFM164_S03g001275</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QET0"/>
    <dbReference type="STRING" id="1365484.W6QET0"/>
    <dbReference type="OMA" id="CPRYISE"/>
    <dbReference type="OrthoDB" id="5126878at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053178">
        <property type="entry name" value="Osmoadaptation_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38111:SF5">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38111">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="9"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="48"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="511"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="54"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="73"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="516"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM34551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="532" mass="58925" checksum="01086D48BF31B91F" modified="2014-04-16" version="1">MVGVPHSTGCALCRERRIKCDEAVPECTQCQKYGRTCPGYRRTFRFQDEGPNLARRHRSNTRRKGRSTLAGPATSSTRINQFSSHGDPSATAEIVRGNAIALMRRQSSLGGWDEQLLARKSFRAAQPQLFLDFISTSFPTFYFHNLFRSGDTPGFAENLVMNYGQDAYLDSAVCCLSSVYLAHLTQDKALLKISRQMYSQSLREVMRAIPKADHANSDNMLCTSIVLSVFEMFAQTAPDAWVVHSEGAKRLMISRGPAAHESGFGRYCWIAFRGFFIATAVYQGEPCFVDQEEWQSYATKVRTEDCQKPGEWSAYGEVSDLIFMEIAKCPRYISETRDLLSVPYEADSTSIANLITRISDTSQRLRSLAADLRSCISAHSERQQGIVQRPGSFVGPVAESFPDTAPSLLLNGAENMLETLEQLSDRLGDRLCFSSVEVYSPESSVVTPPSSGSEYSISPYSATSRSFALPFRIHSELGQGLSKSSDSHDHRAVSWLDRIASSMGVLGAKVLPGDDPSTSVRMDSSPQVFELQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W6QF21</accession>
    <name>W6QF21_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S03</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S03g001802</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM35075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QF21"/>
    <dbReference type="STRING" id="1365484.W6QF21"/>
    <dbReference type="OMA" id="YSYVAPY"/>
    <dbReference type="OrthoDB" id="376826at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM35075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="187" mass="20834" checksum="95A240FB5A0A7BC4" modified="2014-04-16" version="1">MPHAEVKMGEPVVNGEKHYSQFLDHLTSYPIISDSISYYKGNPYGAKSLEFADQGYTRLAKPVLPYFSTPYSYVAPYIARADSLGDKGLTKIDTRFPIFKEDTQKLRGSIYNSASLPVRVAGDVKHHVFDVYGSEYKKCGGDGVFASGKAVVTTSLVLSQESLAWVSTFLQSKKEETKEVVNEKYNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W6QF73</accession>
    <name>W6QF73_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="6">AMP-dependent synthetase/ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PROQFM164_S04g000304</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QF73"/>
    <dbReference type="STRING" id="1365484.W6QF73"/>
    <dbReference type="OMA" id="DAPINGY"/>
    <dbReference type="OrthoDB" id="429813at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051414">
        <property type="entry name" value="Adenylate-forming_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439:SF2">
        <property type="entry name" value="ENZYME, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439">
        <property type="entry name" value="PHENYLACETATE-COENZYME A LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23562">
        <property type="entry name" value="AMP-binding_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="241"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="4">
        <location>
            <begin position="27"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="Thioester reductase (TE)" evidence="5">
        <location>
            <begin position="726"/>
            <end position="960"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDM35423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="1090" mass="121523" checksum="C2ED9BB088BA42CB" modified="2014-04-16" version="1">MAASNKQCTTQHGESRVGSRILLNYIEATASNSPDKTAIQQLIQPEHAEPNQPHEVIVSYLGLFNAINYLSWQLDNLAIKPNGSTVIAYLGPSDLRHLLISLVATKMGKQALLISPRVSISMARYLLELSNSPVMVFESTFSSTVDEISKTRSIQTFQIQDLVELLRGPKQIKNYPYDGSWATLRSTPAVILHTSGSTGIPRLVPISHSSLAASDAQRLISQQDPKGRKCQLEIMSDARTVYVAFPLFHVAGFALSSYLLFSGTTLMFGYYHRPPSILMLQIAMRDSQLDGALLPPSIVEELSENLEAMNSASKFKWIFTGGGSISQKKGDTVVTKTQLFNGLGSTECGSFIQYSNDPSHWNYFHFHPLNGIHWRPIDPEAEGNEPEFEMVIRRDRSLESYQSVFHNFPELNEWHTKDVFKKHPTEPDLWKYGFRIDDIIVFSTGEKMNPVGIESRLGCIPGIKAALVIGNKQRYPGLILEVEGINKAEPSYSNLSSKMKNSVKDALDMENSNSSRDSHIHESMILIANKEKPFVRTPKGTIYRNKSLEQYKTEIDELYSSHSIPSQPNLDDLDLDLTSEESLTSGLAHLIAKILPNTSHLGTDDDIFAAGMDSKQAQMLTAAINNKLASQPVHDIDVGWKVEIGTIYGNPTLLLLGRSILRSLSALFRESGDQENFDEIWQRQVAVLFKMGIYSDLRSRYSHEIPTATTATTTKRNRPTSKHVLLTGTTGFIGSHTLEALLRQKHVRKVTCVNRKSPDSKPTIQTVLREGSTAQCEQLEANLTEPHFGIPDLIYHDLSADVTDILHCQWEVNFNLPLKSFETNIKGVSNLIKFACDAKHKVQIIFLSSVATVKNWQKSEPIPEAKLAFAELAQTGYGQSKLIASLLLDRATELTNLPTTICRLGQISGPTKEQSAEKPWPRRDWFPTFLASSVELGCIPDSLGSANQIDWVPVDIAAEALSDLVCDSNAPSGENHEAPQSRYYHIVNPTHVPFTEFVPFLAQRLRSTEPLEVVTLQKWVDILEDKARSHESSRSPVCGISLLGFFQGLISANQRSVVMDTTLSKKRLPLTKCGAIKEEWMGAWLHRWGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W6QFE1</accession>
    <name>W6QFE1_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ribonuclease H</fullName>
            <ecNumber evidence="3">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PROQFM164_S04g000389</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RNase H family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="3"/>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QFE1"/>
    <dbReference type="STRING" id="1365484.W6QFE1"/>
    <dbReference type="OMA" id="GMRIQFW"/>
    <dbReference type="OrthoDB" id="407198at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043137">
        <property type="term" value="P:DNA replication, removal of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13934">
        <property type="entry name" value="RNase_H_Dikarya_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050092">
        <property type="entry name" value="RNase_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10642">
        <property type="entry name" value="RIBONUCLEASE H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10642:SF26">
        <property type="entry name" value="RIBONUCLEASE H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="9">
        <location>
            <begin position="119"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="40"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDM35508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="296" mass="33318" checksum="E0A49263A3AB834B" modified="2014-04-16" version="1">MPWRPDEPVELPNGRLVCRQHGLVVCGYCTVDYSFMDDDDDDDVDDDDDDVESLDSSDHTDGFVAIPRTGSELRVGTGGVFPTKFMPPNPNDTPKSLFPLTKSENALPPVYRFIRRNSQKTQFLVYTDGACLDNGGANPRAGCSFVYRNSTTNPLLHGFLNFPLEKSGPTGIANLQTSNRAELRAVIAATRFRYWLGEGCRCLVIATDSEYVVEGITKWVKNWIQKDWKTSGGTPVKNKDLWQCLLGEMERWDDRGMRIQFWRIPRELNTEADELAKLAADKDGPQEFEDIKGVLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W6QGF1</accession>
    <name>W6QGF1_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DUF1682 domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PROQFM164_S04g000381</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QGF1"/>
    <dbReference type="STRING" id="1365484.W6QGF1"/>
    <dbReference type="OMA" id="MHLVRDM"/>
    <dbReference type="OrthoDB" id="10039147at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032469">
        <property type="term" value="P:endoplasmic reticulum calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012879">
        <property type="entry name" value="CCDC47"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12883">
        <property type="entry name" value="ADIPOCYTE-SPECIFIC PROTEIN 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12883:SF0">
        <property type="entry name" value="PAT COMPLEX SUBUNIT CCDC47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07946">
        <property type="entry name" value="CCDC47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="73"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="400"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="400"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="422"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM35500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="434" mass="49351" checksum="C0B1084070298DCC" modified="2014-04-16" version="1">MAGMFKNVFGSHEAKPDDDFADFVEAPNPSPASLVADSTVVPAANTLAAKAVPYTAWYRVWERTSPSDFKQEAMIMPFILLIVLFHLWGVRKNRRRARDWAQAHVPSLQKEFAVVGFDGIARPAAVDGITVELANPESLLKEKTASEFAAYATGRQNVAFLDVNIKMPKRYNPITFVMEYVLGFFFESWEPPVEKYEALLYAFDGKEKDLVPVIAKDASPVKLPSSTYDGFIWAVVHKSHMRKFRNDRYDASITFSKDNPKLPSWVTVMTESAEISDTLLTPELIQAIEQAGNDFEFLIVTDQPVDRPTKIEETVPKKRIQLSANLASSASGYASTLPLFNQFLRLSDKLVASAHFRGEVMRKVRNVREEEIKKLRRVDEEEKAEERRIAAEKLKKDERERILRGMSAEEQRKFLDREAQKGQRRQAKKSTRKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W6QGV3</accession>
    <name>W6QGV3_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Nucleotide-binding, alpha-beta plait</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PROQFM164_S04g000939</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM36058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QGV3"/>
    <dbReference type="STRING" id="1365484.W6QGV3"/>
    <dbReference type="OMA" id="RNDYPRD"/>
    <dbReference type="OrthoDB" id="5382468at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12418">
        <property type="entry name" value="RRM_Aly_REF_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051229">
        <property type="entry name" value="ALYREF_mRNA_export"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025715">
        <property type="entry name" value="FoP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19965">
        <property type="entry name" value="RNA AND EXPORT FACTOR BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19965:SF82">
        <property type="entry name" value="THO COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13865">
        <property type="entry name" value="FoP_duplication"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01218">
        <property type="entry name" value="FoP_duplication"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="88"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="60"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="160"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="34"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="74"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="291"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDM36058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="319" mass="35583" checksum="88D09B6EE980D1AB" modified="2014-04-16" version="1">MDRSLDEIIAEDTRNPGRTSGGGGGSRRHNNSGRRHERDGVRKPYTSDRVDLNLDWVHDKFDDDRSRPSRGGRRGRDGHDSDRPSSLTKVRVDNLHYDITESDLEDLFGRIGPVSELTVSYDRAGRSEGVAFVTYARLKDAHLSIQEYDGANAKGQPIRLSLVPGRRERNPLESAQRPRSSLLDRVERPRDDRSMSPEDSDRRRRGGRAHRSDVTKPAPDNIDRYVPGQRSSQRSPNRRGGGRRGGGRDNRSQQTEGSNRRSNARPRKTQEELDQEMEDYWGSANNGGGEAAAPAQDAPQQTAPAPSAPAADDDIDMIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W6QH21</accession>
    <name>W6QH21_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g002723</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QH21"/>
    <dbReference type="OMA" id="WGYKPFL"/>
    <dbReference type="OrthoDB" id="10250441at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11440">
        <property type="entry name" value="LECITHIN-CHOLESTEROL ACYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="410"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="722"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="777"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="40"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="150"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="338"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="734"/>
            <end position="746"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM28912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="940" mass="102343" checksum="3594DD2CC7809C23" modified="2014-04-16" version="1">MVSISADQPASESAATAAPTNSHQQALYSSETASSNLLGSDSPSQYSSFSSSDSDEPLSDEPIPHSTEVTDEDAAGDVVGVSIGREQSRMKARATPVEEKNRVLEHQGSYFSTIPDTIGEDGLFASELTAEPETVEPKVEKAPAPKPKRAPTSAPRPATGGERREHKPRPSYSSAQYDEPEPGKLAHGPRSDLFASAHEKTGSKDAAGSQRSGFVGALLKNSLPRRPRAWSNELKKFLPDLTSLRKRPSLAFRAHNGQNRIRSQTVAPAAKKPLSQPKRTSSLVLHPQRSPLAPSGSSIEDEGEAAQSIPELRSPDGTSAAKHSFTRRPSSVMPGRPPSLRRSSSDQSLYLRASSTASSLEQRPLYENVHSQVNSRFKAIKDSFQDSSNRLLSMPNLHLQDIRNEWGQFLPELGNGNNNGASSTSKEEQSPRAESPPPTPRHNPNSSHPVLEEAMEELTGDVVILGGYRGSILRSAKPPHRQLWVPMKVGLNLRKVDLEVGLKPEDEEHMEETIIPSGVLSHVGPVDVCRRLMKRLRRSENAQRGEMRVHDYGYDWRLSPELLSRRLIAFLESLPCNQEPSPGEPRRGAIVIAHSLGGLITRHAVNERPDLFAGVVYAGVPQHCVNILGPLRNGDDVLISSRVLTAQVNFTFRTSFALLPEDGHCFIDKQSKKEFRIDFFNAQTWEDYRLSPCMAPALPVPPTPTTLGFKDIPIIGKRFSMGPRDDSDESITQDPHHVTQDGHHSTAAVDKDVSARNNNSPHSAAAYAAYASEKAHDPADGLVGPGAHPRSSTTTTSKIATTCTIPHAAAREYLERTLAETKRFKENLAFRPTLHSENRYPPAAVLYGKTLPTVYGARVVSRETIKQVDAYDDLAFAAGDGVCLASAAMLPPGYRIIKDGLVKSERGHVGLLGDLEGVGQCLKAIHRGRKEGVGLGEKNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W6QH93</accession>
    <name>W6QH93_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Acyl-CoA N-acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PROQFM164_S05g000026</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QH93"/>
    <dbReference type="STRING" id="1365484.W6QH93"/>
    <dbReference type="OMA" id="NVSHACL"/>
    <dbReference type="OrthoDB" id="4215304at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009254">
        <property type="term" value="P:peptidoglycan turnover"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.300:FF:000008">
        <property type="entry name" value="Beta-N-acetylglucosaminidase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1700:FF:000013">
        <property type="entry name" value="Glycoside hydrolase family 3 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050226">
        <property type="entry name" value="NagZ_Beta-hexosaminidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30480">
        <property type="entry name" value="BETA-HEXOSAMINIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30480:SF8">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04060)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycoside hydrolase family 3 N-terminal" evidence="6">
        <location>
            <begin position="15"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM36193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="930" mass="101481" checksum="98A417527FF99F9D" modified="2014-04-16" version="1">MARKEGMLPPGWEDLDRQMGQLFMMGFDGTEVNPQIRSLIENYHLGTVMLSAKNLKSAEDATRLVLELQTIARDAGHPVPLLIALDQENGGVNSLYDEIYIRQFPSTMGIAATGSKSLAHEVAVATAQELKAVGVNWILGPVLDVLTNVRNQPLGVRTAGDDPQEASQYGVQFMKGYQEAGLVTCGKHFPSYGNLEFLGSPTDVPIITESLEQLSLNALVPFRNAINQGLDAMIVGGVSLSSAGMNVMHACLSDQVVNELLRKDLQFQGVVVSECLEMEALTHNIGVGGGTVMAKNAGCDVMLLCRSFPVQQEAINGLKLGVENGIISRQRIEQSLRRVLDLKARCTSWEQALNPPGLSSLTQMQPSHTNLSTRAYNSSITVMRDKNNLLPLSNVIEPDEELLLLTPLVKPLPTSAVSLSVAESARGSLDPLCSERTSSILSGEGVFKELGRSLSRQRNGRVLHTSYTSNGVRPIHDDLIQRASAVVVVTADANRNLYQQGFSKHVAMICQSQYTPSGERRAKPLIVVAVSSPYDFAMDSSIGTYICTYDFTETALQALVKVLYGDLTPSAALPGSIGRTQKIHQSRQHWLVENWNEDRDSFALDALLDTIRVDCTLGQPSELLGATASSFLLRKEDIDEAHFVVRNSSTHALYGFCATYFFRSTGTGVIACLIVDPSRRKLSIGHSLHSRAIRTLLQRTGMKRFQLGSRLPGIYLGIPTVNPVERKRLRQWFANMGWNTALSRPVCSVIMRNLSTWVPPEGLTATLQNAEVTYDLVYGWDFAPAILDHIKTYARQGVADIYRMALGGAPNCGIIRAKRPSDGVILGSIVIYNERSALAEHMPVLRATQASVGGISSPVISPCGEHYSTVMQGLVLLAIKQIRKLSADAVVMDCVDGDGNFDNLSMMGFTMLHSFEEVNCDAASWTMMHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>W6QHH1</accession>
    <name>W6QHH1_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Clathrin adaptor, mu subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PROQFM164_S04g000756</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Clathrin-coated vesicle membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the adaptor complexes medium subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QHH1"/>
    <dbReference type="STRING" id="1365484.W6QHH1"/>
    <dbReference type="OMA" id="KPLIWCD"/>
    <dbReference type="OrthoDB" id="10259133at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030131">
        <property type="term" value="C:clathrin adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030665">
        <property type="term" value="C:clathrin-coated vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09250">
        <property type="entry name" value="AP-1_Mu1_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14835">
        <property type="entry name" value="AP1_Mu_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000006">
        <property type="entry name" value="AP-1 complex subunit mu-1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1170">
        <property type="entry name" value="Mu homology domain, subdomain B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050431">
        <property type="entry name" value="Adaptor_comp_med_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036168">
        <property type="entry name" value="AP2_Mu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001392">
        <property type="entry name" value="Clathrin_mu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018240">
        <property type="entry name" value="Clathrin_mu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028565">
        <property type="entry name" value="MHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10529">
        <property type="entry name" value="AP COMPLEX SUBUNIT MU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00928">
        <property type="entry name" value="Adap_comp_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005992">
        <property type="entry name" value="Clathrin_mu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00314">
        <property type="entry name" value="CLATHRINADPT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49447">
        <property type="entry name" value="Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00990">
        <property type="entry name" value="CLAT_ADAPTOR_M_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00991">
        <property type="entry name" value="CLAT_ADAPTOR_M_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51072">
        <property type="entry name" value="MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MHD" evidence="8">
        <location>
            <begin position="167"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR005992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM35875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="447" mass="50603" checksum="DC4BA064CE0F013F" modified="2014-04-16" version="1">MASALFFLDLKGKTLLARNYRGDIPMSAVEKFPILLSDAEEESSAVPPCFSHEGINYLYIRHSNLYILALTKRNTNATEILLFLHKLVEVFTEYFKVLEEESIRDNFVVIYELLDEMMDFGYPQTTESKILQEYITQESHKLDVQARPPIAVTNAVSWRSEGIRYRKNEVFLDVVESLNLLVSANGNVLRSEILGAVKMKCYLSGMPELRLGLNDKAMFETTGRATRGKSVEMEDVKFHQCVRLSRFENDRTISFIPPDGEFELMSYRLNTQVKPLIWVECVVESHSGSRIEYMLKAKAQFKRRSTANNVEILVPVPEDADSPRFRTNIGTVHYAPEKSAIIWKIKQFGGGKEFLMRAELGLPSVKGDDERGGGMTGGFGGSMGGAGGVGKSKRPINVKFEIPYFTTSGIQVRYLKITEPKLQYPSLPWVRYITQSGDIAMRMPEIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W6QHU3</accession>
    <name>W6QHU3_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Vacuolar membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S05g000201</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QHU3"/>
    <dbReference type="STRING" id="1365484.W6QHU3"/>
    <dbReference type="OMA" id="MLVIWAA"/>
    <dbReference type="OrthoDB" id="431202at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022127">
        <property type="entry name" value="STIMATE/YPL162C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31735">
        <property type="entry name" value="VACUOLAR MEMBRANE PROTEIN YPL162C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31735:SF1">
        <property type="entry name" value="VACUOLAR MEMBRANE PROTEIN YPL162C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12400">
        <property type="entry name" value="STIMATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="133"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="192"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="230"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM36368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="356" mass="39092" checksum="6FF493393594909D" modified="2014-04-16" version="1">MDGTTGSLASIATTTLIAASSLAIPTPSGAHTLYYDATNSSSPGQDPNGEGGECKLLGPFSVFVQIALGSLALLSLVYKRWRERPQRPVKIWAFDVSKQVFGSVMLHMLNLVMSLFSAGQLEIRSSYKPNPCSFYLLNLGIDTTLGIPILILLLHVLNRLASYTPLANPPESIESGNYGQPPRITWWLKQAIVYFMGLLGMKICVFFLIELLPFIVTIGDWALRWTEGHAAVQIFFVMLLFPVIMNAIQYYIIDIFIKKPVSQYVVDDTVGDFTIDDDAHRREALLAGQDESDSADSDDEEAGKSPRTTSQPKATADALQGERLLPEDDNPVPPYEPPSSSGSGEERYLKASSTQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W6QHY2</accession>
    <name>W6QHY2_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g003019</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QHY2"/>
    <dbReference type="STRING" id="1365484.W6QHY2"/>
    <dbReference type="OMA" id="NMPVQAK"/>
    <dbReference type="OrthoDB" id="20105at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="327"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="404"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM29207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="513" mass="57658" checksum="0AF4333DB827969D" modified="2014-04-16" version="1">MAMTEEASASDFEMSIRTILLEKEYEKTLSVSARLLDEERDRVRRMELLLSKFENEALRSQLKEANGHLLGFTSADSEACAQLQEACQEIDHLELRAQASSIEINRLKEELSVQKNNSTSYKTVLAEKLRLSRELSTLQSELERFRAQNASYQVTISEKHEMERQMNSLELQLDNEKHAHERAQLKASQQMTEITQLSARVGELRAELAGELRAKQQQEQDNHHQNLAWANERATFEGKIDSLKQQLRSTKDKLQEAQVEIQQRRNVKSHAGNNSESSSRKIPLQRPGPSAGVTIVTPGAVRVQEQLKKHSAVPGDKSAFSITPFLNRTGAPSDSPMSSVGDEDEILGNDDTPRGPLGKQGTFGEQKRIGSALRRQLSPTEDRIPITKSTKPRARDGAMPVSAPDKEVKKPSHRLDRRLPPNEIDELHDQFEHEQAKPKKRKLGGQRDRSLFEEEDEEEPELSKKFGRKLATGNGRALTMGSKTQSTTGLPRALGLGAAPIGFSPLKKDRRRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W6QI84</accession>
    <name>W6QI84_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S05g000361</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QI84"/>
    <dbReference type="OMA" id="CILTIWM"/>
    <dbReference type="OrthoDB" id="4368783at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004879622" evidence="2">
        <location>
            <begin position="27"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM36528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="235" mass="25927" checksum="6B04CCF8A52149CA" modified="2014-04-16" version="1">MQVSPKFHTALATVLLIASLVRLELSRRAARGISHLALDLAVSVPKDVLLVVYVGLSWAEISEAVREGILGISSVFPFLLVSLRMSILLRSLTGTPSRLVICFSLFFLSSILIKITATLVGIYVYLPLQHAVLFLHFVDYLSLAYLLWSLDEYTTAGSRTGLQLRCALHWAMGLAGVLLLIAVFGVVLYCWLLFLELQLCILTIWMILSYYSVRSAGSSVDEQSTCSATVVVREV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W6QI94</accession>
    <name>W6QI94_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S03g000628</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QI94"/>
    <dbReference type="STRING" id="1365484.W6QI94"/>
    <dbReference type="OMA" id="LGWNEPK"/>
    <dbReference type="OrthoDB" id="1708389at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021709">
        <property type="entry name" value="DUF3292"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38694">
        <property type="entry name" value="CONSERVED EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38694:SF1">
        <property type="entry name" value="PEROXIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11696">
        <property type="entry name" value="DUF3292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="166"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM33904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="675" mass="73539" checksum="CF8ABD603B2A2AF9" modified="2014-04-16" version="1">MSATDRQAMPSASVDRATIKADNNLTTDPEIPEGPTDSHVLSQIKQDERGLAQKAGDTAEISNIGWDESPDVIEEPLVAGLSNEDLWMLIRRFDKQMYRVKAVPDVSLQKLDFTREDDDEFSPDKLRATIERFYTTVVVGLTNCIKHIARLRSWKEPRRTAAFCTVYVLSCLLDLLVPTMLVILLALVLYPPCRSLMFPPAPISLVNKDTGGVQKPKAGILGSEDSITGAPEKFKGEAAEQEASNLVASVASVAVGSAVGKHDQGVPDDAPLEDDVPDAMDIVANTADAQSAAHGKVPTDSHDKTRQPMKQSVMDIANSSMHVIGDITDTYEKMGNALSATTPFPRLSPRLRLATVLFPAFLASLMTSCYVFMKLSTLLIGLVFFGDPVIRRGVSYLNRRLPNWRKIIQLQNSLLKGIPTNAQLAITLLRIGEANASPLPPPPTSPDKVPSRPVSLNPEELTLGASNEEIKQAALVKPDDHVQAVEAPPAPEKSHKRTLGSSILGLFRETTASGVESKRGIDRLRAAIGSHHAKNRVGVLRDRGKRITPSGPVAFDARYKGKRGTAIIDSTKEPPLLYFTTDTPQNGDAKLENRKDGSVMFTMPVTEIQEMRKLGGMGWKGKLVVGWALHGKEVVDGLLIIGKMPGQSYQLTAMETRNQLFNRLIAIDGQVWASC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>W6QI97</accession>
    <name>W6QI97_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">H/ACA ribonucleoprotein complex subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Nucleolar protein family A member 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">snu13</name>
        <name evidence="12" type="ORF">PROQFM164_S04g001036</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Common component of the spliceosome and rRNA processing machinery. In association with the spliceosomal U4/U6.U5 tri-snRNP particle, required for splicing of pre-mRNA. In association with box C/D snoRNPs, required for processing of pre-ribosomal RNA (rRNA) and site-specific 2'-O-methylation of substrate RNAs. Essential for the accumulation and stability of U4 snRNA, U6 snRNA, and box C/D snoRNAs.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
            <location evidence="1 10">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the eukaryotic ribosomal protein eL8 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM36155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QI97"/>
    <dbReference type="STRING" id="1365484.W6QI97"/>
    <dbReference type="OMA" id="IKNQIYA"/>
    <dbReference type="OrthoDB" id="1924699at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031429">
        <property type="term" value="C:box H/ACA snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031120">
        <property type="term" value="P:snRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000002">
        <property type="entry name" value="NHP2-like protein 1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050257">
        <property type="entry name" value="eL8/uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002415">
        <property type="entry name" value="H/ACA_rnp_Nhp2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004037">
        <property type="entry name" value="Ribosomal_eL8-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018492">
        <property type="entry name" value="Ribosomal_eL8/Nhp2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23105">
        <property type="entry name" value="RIBOSOMAL PROTEIN L7AE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00881">
        <property type="entry name" value="L7ARS6FAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00883">
        <property type="entry name" value="NUCLEARHMG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01082">
        <property type="entry name" value="RIBOSOMAL_L7AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10 12" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="11">
        <location>
            <begin position="20"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDM36155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="126" mass="13556" checksum="4D681D77B9E1AE27" modified="2014-04-16" version="1">MAEDTSAAWPIADEALAQSLLDLVQQAAHYRQLKKGANECTKSLNRGTSELVIMAADTSPLAIVLHLPLLAEDKNVPYVYVPSKMALGRATGVSRPVIAASITTNEASDLTAQIRAIKNQVERLMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W6QIF4</accession>
    <name>W6QIF4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S03</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S03g000708</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QIF4"/>
    <dbReference type="STRING" id="1365484.W6QIF4"/>
    <dbReference type="OMA" id="KYNESYP"/>
    <dbReference type="OrthoDB" id="5400063at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="163"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM33984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="298" mass="32217" checksum="442F3AD34077DAE5" modified="2014-04-16" version="1">METPGEMRPRKPGTNTGVIPVVPEDKEDVMITFSLSEPSASPRTRSPLARSHLRSRSLAGIPGMPSMTRAYSSPGPDSQGRYIFINGRGAPVDAKRSPLQMRPDDYSDRMGALNISETISENAELETNPKSSSQPASSPVLMPQTFPRINRLRPTSPLPFQTPISPSLHSPPILGSKYNESYPSHPGSVSSISVPSTPTSLRSRSPSISSLETIPDIPDAENEALEEDRIAELKAAADAADAASTANRRRGASDAPSSFTTMRGGSGGYATRSEKRKRWSVCGAERRQDLDLETIWED</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W6QIT0</accession>
    <name>W6QIT0_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycine zipper 2TM domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S03g000843</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QIT0"/>
    <dbReference type="STRING" id="1365484.W6QIT0"/>
    <dbReference type="OMA" id="DTDRGMD"/>
    <dbReference type="OrthoDB" id="4368344at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019867">
        <property type="term" value="C:outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008816">
        <property type="entry name" value="Gly_zipper_2TM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37014:SF9">
        <property type="entry name" value="CONSERVED HISTIDINE-RICH PROTEIN (AFU_ORTHOLOGUE AFUA_1G11910)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37014">
        <property type="entry name" value="EXPRESSION LETHALITY PROTEIN HEL10, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G06580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05433">
        <property type="entry name" value="Rick_17kDa_Anti"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycine zipper 2TM" evidence="2">
        <location>
            <begin position="167"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM34119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="266" mass="29760" checksum="B4028F7863E7ECDA" modified="2014-04-16" version="1">MGDPYNTYNSHSTPTPSGVDYYRPEDQPQYPVYGHRQPYGNQGPYQNPGSEPYQPSPNPNQAYAPQQSPYQLAPDPYGSSTERSYTPTGQPDYLGPVVPTGYQHAQDRIPGNAEYYNNHPASQPRYTPSASPHPPAVYASEPEYSQRSGEQRFDTDTDTDRGMDRGLGGSIAGGVAGYYLGHKKEHGLLGAIGGALLGNFIENKVKDHKRRDIDSEYEHGHDHGDHRSRHHHHHGHRSHSRDSSHSGHSGHSHHTSHSRHYYEDEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W6QJB4</accession>
    <name>W6QJB4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S05g000343</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QJB4"/>
    <dbReference type="OMA" id="RITPFHL"/>
    <dbReference type="OrthoDB" id="4305546at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="95"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="56"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM36510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="148" mass="16837" checksum="C4DEE43A2A92C569" modified="2014-04-16" version="1">MSYAQILRSSRQPGGYEAQIASLMPPEEEQQQTRITPFHLKGNPDLGSRAKYEKAAQQSSRSTQQNQDLHKRVKKIEHFINGITQNGFADVLTENATLLSETTALKDKIQELEETLENMQARVDELCKERQVSTVQNNPARKKRAMPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>W6QJX0</accession>
    <name>W6QJX0_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 16">Histone acetyltransferase type B catalytic subunit</fullName>
            <ecNumber evidence="4 16">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">hat1</name>
        <name evidence="22" type="ORF">PROQFM164_S06g000078</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalytic component of the histone acetylase B (HAT-B) complex. Acetylates 'Lys-12' of histone H4 which is required for telomeric silencing. Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. Involved in DNA double-strand break repair.</text>
    </comment>
    <comment type="function">
        <text evidence="16">Catalytic component of the histone acetylase B (HAT-B) complex. Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. Involved in DNA double-strand break repair.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45948"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.48"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="15 16">Component of the HAT-B complex composed of at least HAT1 and HAT2. The HAT-B complex binds to histone H4 tail.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 16">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 16">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the HAT1 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="4 16"/>
    <dbReference type="EMBL" id="HG792020">
        <property type="protein sequence ID" value="CDM37118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QJX0"/>
    <dbReference type="STRING" id="1365484.W6QJX0"/>
    <dbReference type="OMA" id="WTCDAND"/>
    <dbReference type="OrthoDB" id="10253098at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031509">
        <property type="term" value="P:subtelomeric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000125">
        <property type="entry name" value="Histone acetyltransferase type B catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.360.10">
        <property type="entry name" value="Histone acetyl transferase 1 (HAT1), N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019467">
        <property type="entry name" value="Hat1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037113">
        <property type="entry name" value="Hat1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017380">
        <property type="entry name" value="Hist_AcTrfase_B-typ_cat-su"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12046">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE TYPE B CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10394">
        <property type="entry name" value="Hat1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038084">
        <property type="entry name" value="HAT-B_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 16" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="6 16" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="11 16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 16 22" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histone acetyl transferase HAT1 N-terminal" evidence="21">
        <location>
            <begin position="7"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interaction with histone H4 N-terminus" evidence="18">
        <location>
            <begin position="44"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interaction with histone H4 N-terminus" evidence="18">
        <location>
            <begin position="210"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="450"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="20">
        <location>
            <begin position="483"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="17">
        <location>
            <position position="284"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <begin position="249"/>
            <end position="251"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="287"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="site" description="Interaction with histone H4 N-terminus" evidence="19">
        <location>
            <position position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00053467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00063577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR038084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR038084-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR038084-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR038084-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF10394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="CDM37118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="502" mass="57903" checksum="43E8863CEED46A09" modified="2014-04-16" version="1">MASEAGWSCDANDAVHVTIIQPGEKKPKTLSTFHPQFTYPIFGDDEQIFGYRGLIIRLRFAAHDLRPHVHISYDEKFKSVGDTAAVDLLDTLKPFVQEEAFADLQDYEKAVQNDPDAKDFKPPGEFVISYEVEDRKYEVWAGSLADPEVRKILDRMQVLVSLFIEAGTPLETDDPEWTLDRWRVYFVYEKVTPPTATASSYSIVGYATTYRYWYYQRDQSQTPAVKNEVFPLPEVNIAKLPARLRIAQFLILPPHHRAGHGTHLYTTIHAACIADPTILELTIEDPNEQFDALRDTADYCLLRPEFLRHNVNLNPDPLGAYSQKKRPRNVPTSALIPTKLLHDIRRSFKIEPTQFAHVLEMYLLGQIPQSHRLAGGTNLARLLIKKYKAENEDDRRYYWWRMLTKQRLYKKNKELLNELELLDRVEKLDATVQNVEEGYEITLDALEGRLPEGEDEEEEANKQVSKAPTGSRDRRVKRKLTVMDDDDDEEEDGTQLAKRPKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W6QKB5</accession>
    <name>W6QKB5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein kinase, ATP binding site</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S03g001394</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QKB5"/>
    <dbReference type="STRING" id="1365484.W6QKB5"/>
    <dbReference type="OrthoDB" id="5979581at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <position position="24"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM34669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="66" mass="7722" checksum="75332675B789F9FA" modified="2014-04-16" version="1">MRKLGYGQYSTVWLARDSKYVALKILRADCYGGSYDIFEREILSKLSNISRKSNHEGRYYVLPLLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W6QKJ0</accession>
    <name>W6QKJ0_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein kish</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">Tmem167a</name>
        <name evidence="10" type="ORF">PROQFM164_S02g000246</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Involved in the early part of the secretory pathway.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Golgi apparatus membrane</location>
            <topology evidence="2 9">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the KISH family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QKJ0"/>
    <dbReference type="STRING" id="1365484.W6QKJ0"/>
    <dbReference type="OMA" id="KVGFQGT"/>
    <dbReference type="OrthoDB" id="10034655at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051523">
        <property type="entry name" value="KISH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009653">
        <property type="entry name" value="Ksh1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13229">
        <property type="entry name" value="PROTEIN KISH-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06842">
        <property type="entry name" value="DUF1242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0732">Signal</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005151048" description="Protein kish" evidence="9">
        <location>
            <begin position="25"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU910717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDM30097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="72" mass="7994" checksum="EB735D893648F69C" modified="2014-04-16" version="1">MSALFNFQSLLLVILLIICTSSYAHSIMPGIMDRNQNGIFGIFWKSARVGERLSPYVSICCVVMAVSIFFGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>W6QL90</accession>
    <name>W6QL90_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Proteasome subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PROQFM164_S03g001696</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Non-catalytic component of the proteasome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase T1B family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QL90"/>
    <dbReference type="STRING" id="1365484.W6QL90"/>
    <dbReference type="OMA" id="QPIMRRY"/>
    <dbReference type="OrthoDB" id="10248542at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03760">
        <property type="entry name" value="proteasome_beta_type_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000014">
        <property type="entry name" value="Proteasome subunit beta type-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016295">
        <property type="entry name" value="Proteasome_beta4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF6">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001213">
        <property type="entry name" value="Psome_endopept_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 4 5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR001213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDM34969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="260" mass="28645" checksum="01DF159A3077F04D" modified="2014-04-16" version="1">MNHSPEAWGRPRNDVYGAYDHSYLQTTGPKAHTSSPAVTGTSVVGVKFNGGVVIATDNLASYGSLARFSDVKRLRTFGDKAMVGFGGDVSDMQYIDRLLDSMDIKENYSPHGNMLNAKNLHTYLAKVFYKRRSEFNPLWNHVLVAGFDAEGEPFLSSADLLGTTFSAPHLATGFGAHLAVPILRRKFPEGTPLEQVSKEDAVDALKECLKVLFYRDARSTDKYSIAVITKDGIDLKEDEQIQGQSWAFAERIRGYGAQTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W6QM17</accession>
    <name>W6QM17_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Prefoldin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PROQFM164_S07g000221</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792021">
        <property type="protein sequence ID" value="CDM37873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1365484.W6QM17"/>
    <dbReference type="OMA" id="HAQQNYE"/>
    <dbReference type="OrthoDB" id="343070at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057974">
        <property type="entry name" value="NUA/TPR/MLP1-2-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012929">
        <property type="entry name" value="Nucleoprot-TPR/MLP1-2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057577">
        <property type="entry name" value="Nucleoprot-TPR/MLP1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18898:SF2">
        <property type="entry name" value="NUCLEOPROTEIN TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18898">
        <property type="entry name" value="NUCLEOPROTEIN TPR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25481">
        <property type="entry name" value="Nucleoprot-TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25785">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07926">
        <property type="entry name" value="TPR_MLP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleoprotein TPR/MPL1" evidence="7">
        <location>
            <begin position="184"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="NUA/TPR/MLP1-2-like" evidence="8">
        <location>
            <begin position="489"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoprotein TPR/MLP1-2" evidence="6">
        <location>
            <begin position="1070"/>
            <end position="1198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="98"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="234"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="370"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="858"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="936"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1002"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1498"/>
            <end position="1527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1608"/>
            <end position="1632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1678"/>
            <end position="1698"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1821"/>
            <end position="2007"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="305"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="420"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="571"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="1309"/>
            <end position="1493"/>
        </location>
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        <location>
            <begin position="1701"/>
            <end position="1728"/>
        </location>
    </feature>
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        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="247"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="866"/>
            <end position="890"/>
        </location>
    </feature>
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        <location>
            <begin position="936"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1004"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="1504"/>
            <end position="1514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1616"/>
            <end position="1630"/>
        </location>
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        <location>
            <begin position="1678"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1840"/>
            <end position="1868"/>
        </location>
    </feature>
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        <location>
            <begin position="1892"/>
            <end position="1901"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1902"/>
            <end position="1925"/>
        </location>
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    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="1926"/>
            <end position="1940"/>
        </location>
    </feature>
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        <location>
            <begin position="1947"/>
            <end position="1964"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="1986"/>
            <end position="2007"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07926"/>
        </source>
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        <source>
            <dbReference type="Pfam" id="PF25481"/>
        </source>
    </evidence>
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            <dbReference type="Pfam" id="PF25785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM37873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="2007" mass="223618" checksum="439333E762ACB79A" modified="2014-04-16" version="1">MAETAIQLPYLSSHYALPESTLTTLRQAPTVELVNQLLESINKKAHESDELKSDKLRLEVELENSVRSNESKVKVLKASVEKGHAEVADLRKKLHEAETTRSSLETEISTLKSSSTSNESETTSLKARISSLEASNRDTLGLLESKSAAYDKLAEELSLQHKKTIELRRELSTAEQSLQSANAASASARFREQSLQQELDLTKKNNEWFETELKTKSAEYIKFRKEKGARISELQRENEEANSTIDSLRRSENSLKSRLDETEQRYETSLASIHQLKEEAIQATESFRIELDSSNRLAELQGSAAQTAKQRVQECQLALEKTKDDAAQEISRLRVELETESNDKGAAERRIAELEALVAQLEFEPARGRSASPAVSLNGGAPSTPLRSSIMRAGTPTGSFSPRTSRGKGGMNVTQMYSEYDRMRTALAAEQRTCQELRNTVDEMVLELDSTRPEIEEGRAEQMRLDHAVVEMSTLLEAAGKERDTALKEARKWQGQVEGLAREGDILRQQLRDLSAEVKVLVLEVAVAKHGEEYDREELEKIARGEVEESAKDLNETGRFISKHLTTFKDLHELQDQNHTLRRMLRELGDKQEGEEAQAKEATRRAELDELKELRIRAQTNRDEIANLSAQMQSYVKERDTFRSMLMHRKPTIDDPSVFSQSMPLGTAPQGAMDTSGPDYAELLRKVQAHFDTFREETTTDHKALRQQVNELSRKNSELMSDISRSNSQLAAASQRAELLQSNFTMLKNENVEIQKRYSSLFENANRQDLRTQQAAEDLVEAKGLVESLQRENANLKAEKALWKNIEKRLIDDTENLRNERGRLDSLNANLQTILNEREHSDSESRRRLQANVESLESELQSTKRKLNDEVEESKKASMRREYEQETSQKRIDDLVTSLGAVREELVAAKTTRDHLQSRVDELAVELKSAEERLQVVNSRPSVSAGTTEGPTEDQESGEGSGLSREQELSIEVSELKRDLELAKGELEHAKQLAEDYQAISQASEERLESATETQEQYREETDRLVEEKNTKIQDLETRIEEISAELSTSNTEMTKLREEQAEATRRLEEQKANFESEITRLKADNERHVTAAQYHQEDLNAQAEIAKHAQQNYETELVKHAEAAKNLQVVRAESNQLRLDIAELRTQSEGYKTDLSQKEESWAEQRATYEGELSELQKRREEVLHQNSVLHTQLENITSQISSLQRDRMNVSDDEAEGDQAAPNLEGLQEVIKFLRREKEIVEVQYHLSTQESKRLNQQLDYTQSQLDETRLKLEQQRRAAADSDHNALNHSKLLDTINELNVFRESNATLRNQLKQTEAVRDQKIARENELVQEIEPLKTRIHELESQSEAKDGEMQLLQADRDRYQQRIQNILQKYDRVDPTEMQELKEKLSSLEKEKNEAVSEREALQTQMESLQAQIAQFPEQLKQHSDERAQDLRSKLTEQFKARSKDLSARVKAKQDELNVALQEKEVIQLELQTTKNELEALKTKVAEAPANVSPTPIPTPAPAPAPAAEQEAPVNATPASQFPTATVQIPGPSDIQRIQALEQKIQRLEAALAEKDGLLATQASEQDAKVKERADRLKDMYNSKLNEVKAAHRQEIEKLSAGEQSIPGTPGAAPDATPATPSKTFELAGFTIPELTDAQARELVAKHETIRTIVRNNIRGQVAREQQKLQQEAQASSGANEAALAGLQQKSTEEKEALIKAHENELKEKVNSAVELVEKKTAARLSMLDTRFRTANAKIDVVSKAATETPQKPVVEVWEIAKTARPAPIAVPAAKPPVPVQPAGPAPTLAAPQVPVSAPAPASVPASVPVVGAPEQAAPPTASSGPAVPQQGGTQPATPANPFGQVQQPDQNQHASSLPSKPPAGNPPGLMRALQSGLPIARGGRGGRGGNQQFGHQQHDQQQQQGGQGQNQRGQGLQRGRGGRGGQGRGGNQNQNNVAQAQSPTANRGNLSASARQFIPAGNKRSRDDGPDTTTDGGSGGKRQRGGGGPQARGGASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W6QM38</accession>
    <name>W6QM38_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Two-component system protein A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">tcsA</name>
        <name evidence="8" type="ORF">PROQFM164_S06g000016</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792020">
        <property type="protein sequence ID" value="CDM37056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QM38"/>
    <dbReference type="STRING" id="1365484.W6QM38"/>
    <dbReference type="OMA" id="VGFHANP"/>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16922">
        <property type="entry name" value="HATPase_EvgS-ArcB-TorS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.20:FF:000136">
        <property type="entry name" value="Sensor histidine kinase/response regulator Fos-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45339">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45339:SF1">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="PAS" evidence="6">
        <location>
            <begin position="187"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="7">
        <location>
            <begin position="246"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="4">
        <location>
            <begin position="312"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="5">
        <location>
            <begin position="569"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="3">
        <location>
            <position position="621"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM37056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="688" mass="76672" checksum="819EE30BA8685BEC" modified="2014-04-16" version="1">MPVDQMLHLRIDCPMNNVAMVITPPAESDLNLENKSLEQPVVGSLSRIYRFTPKPTLVLDGALRIVEVSNSHVEVFKHSRDQLLAANVYDLPPSILPAPDIASLIGALGTAISTREVQVIQRVHVAKVDAFFSLSVTPIFEDDSLIYMLLEAQRIKHHRHRSNSISDDAYPNEIYKILVDTVRDYAIFMLDTRGHIATWNSGAAILKGYTSSEIIGQHFSIFYGRDDREIKKPVRELEVCLQEGKLEDEGWRYHKDGNRFWANVMITAIYQNGSHVGFVKVTRDMTERRATEARLIDAFEESAKLKSDFLANMSHELRTPMNGMLLALTMLMRTELTDDQREFGSILEDSTSILLQVINDVLDYSKLSSGTFPLNTDVVHIPDVISAVVRNCQSALKPGVKIMGDVSAGFPPNLKGDPLRFRQVLQNMVTNAVKFTESGHVRVHATYTIDEKDPDMYVISTQVVDTGIGVPEDASNTLFTPFTRFADTATKRYQGTGLGLSICKSLAELMGGAVGFHANPDGRGSVFWMTAKMARLTSPVSTVKQRLQPAIPEALDNSASLEKIAPHKHILLVEDNKVNQLIMLKLLSSLGFKRVDAAWDGAEAVRMVKQKPLAYNVILMDISMPVMDGLTATEHIRRMKLDMPILALTGNALKGDAETYLAKGMDDYIAKPLHRQQLVDLLWKWCGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>W6QMW0</accession>
    <name>W6QMW0_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">chitinase</fullName>
            <ecNumber evidence="3">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PROQFM164_S06g000227</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 18 family. Chitinase class V subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="3"/>
    <dbReference type="EMBL" id="HG792020">
        <property type="protein sequence ID" value="CDM37266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1365484.W6QMW0"/>
    <dbReference type="OMA" id="FARIVSM"/>
    <dbReference type="OrthoDB" id="73875at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00035">
        <property type="entry name" value="ChtBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.10">
        <property type="entry name" value="Endochitinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001002">
        <property type="entry name" value="Chitin-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018371">
        <property type="entry name" value="Chitin-binding_1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029476">
        <property type="entry name" value="DNase_NucA_NucB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036861">
        <property type="entry name" value="Endochitinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF402">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00187">
        <property type="entry name" value="Chitin_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14040">
        <property type="entry name" value="DNase_NucA_NucB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00270">
        <property type="entry name" value="ChtBD1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="Chitinase insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57016">
        <property type="entry name" value="Plant lectins/antimicrobial peptides"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00026">
        <property type="entry name" value="CHIT_BIND_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50941">
        <property type="entry name" value="CHIT_BIND_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="4 11" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9 12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004879958" description="chitinase" evidence="14">
        <location>
            <begin position="34"/>
            <end position="1779"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-1" evidence="15">
        <location>
            <begin position="78"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="16">
        <location>
            <begin position="142"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1613"/>
            <end position="1647"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="92"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="97"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CDM37266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="1779" mass="197893" checksum="8D4B64212EEF269C" modified="2014-04-16" version="1">MERPFHLLWKMNSLTWPLLFICLILLQLPSAIAQGPGEPGGTCTDSIPCYQGCCSKDYACGFTDAHCGTGCRSNCNATAECGEFAAPGNSDCPINVCCSSFGYCGVTSEFCGNGCQKNSNGGGCGEPDRPKCSENTDAMSYDRRIGYYELFNIHKGCNVIEPESLIIEPFTHINLAFVNFGDDFKLEDEYGDVVDRVSFLKFTHPGLRVNIAVGGWTFSDAPTQHLWTQMTRSYENRQTFINSVVKYLKDYHLDGIDIDWEYPSASDRGGEPQDAANFVTLLGELREAFDRENPGWEISATLPTSYWYLRGFDPAGMAKYVDYFNLMSYDLHGMWDQDITWTGPYLKGHTNITEIDLGLDLLWRNGIDPSKVVFGFAFYGRSFTMADPNCYQPNGKCEFSDGGIPGSCSDTSGILTYAEVTSRNNSLDVHTFYDPETTVKYNVYEGTQWISYDDEQSFFDKKKFISSRCLSGWMIWAIDQDDGDFDALAGVIGEDLSVMQMEGGGLSGDAANVLADAFAAYTGQNCFVTPRCTDGSSGEKNPDQVCPSGYMSVSTAHNPLQAGNKELRGDCSEGWYRHICCPEDAMPKNCEWNGAPERSEFGCDGKCGSNQFKLNQDTALDAKGEGQCFIGERYLCCDSAAMFSDCRWTNCQGPLMPSTPGECPADNDALTFRWDKPDGKPWCSDTYVSSVDGSVGSPLHDRFKSELCCPSDHSFSVSGCAWTNTLSQADMTDDDWAEHLTDLVCKPRPCSPGKVKVAGALDPPPATGAGSKSEINCAGVTIPPGSNPEWSFCCDPPSRYDKNWPVDPKYLWEKYYNDPKKSDVVWEYSDEYQNNNMDSEPSTEEDGSDAYGFVMLDGPDGSIDNDFATSHTVVRRSREIPRVKRSVLTTNQTLMDTVFDHAEETFHFYCDYPAGSHECERVFIDGAEDTIIRLPDHVGDGPFARIVSMKTAHDEYQLPDHHLEHRSLERNTNPVYEVKIDYNFHLIKLKRDDEPVNIRVDYTNLMGYWDEMTNSPASRAKRGLGEEGLTKDEWRSRVQRAVVRHGNIEKRSEAIHVKTPMEFSGSHLDKRWWGAFKAWLQKLACIPLTKVTKSSLGVIELGFSKTINLFRAQWGCPGQTFSANLRMDLEADLVMDATYAYYLSATFIPPGKPETFAYFGMNPTAYLGLHIEGNAQMQTTTDRKKIIDTLSYPGLAVKGIAAVGPTLDIYGEIRGKVTLHGEATAGAQLSFGKAEVYWPQNDDAKDKYETLLGLQSDVQAPAPGSVEPVFEAGVALDAQLDIIVTPEAHVGIKIGGGKLVGGATLMDAQLTGYVMGDLSFQAHGDYDTTGNEFNYSFGAYLFYNLGYKATAQILNFIDWALAPRLAYDPRKTFKLYEKKGSIPMSSSAKSKREAAIDGPLHRNLVEVGSLTNGSISTYLDSASGLSKRGDEMDIDGPNAPEFTQNLKCPPGTSGDVRLPEIRFNCDFLNDFIEEGKNGKMDAITGLCTPVLNIPDNKRQKLFTFSNDKLRKEARYNAQCKSGTCTQATTDLRDHQGNKKLELQCDEFPWKSSEQGGDYLASDARTGTCVASYQNNWHGQCLRMIGYMQSNWAKLEPEREDGDNRGDFWQDWREDSWTKPGQHGSKGSQYEQRLKEYPEKQPLPDGVTTRNNDKISWVFKRDYEVSFIRQDPSTIDGSTWWGATSHKFQKTTHSGPSGMDAIFCAINHFGQDNVYKLPNGYNGLCRRNNGSPLTGWNVGFNMARCEVKFANPSSSNKRSIGTFAGWEVESVRMLDEDDHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W6QN78</accession>
    <name>W6QN78_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Stress-response A/B barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S02g001252</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QN78"/>
    <dbReference type="STRING" id="1365484.W6QN78"/>
    <dbReference type="OMA" id="GIQNGMT"/>
    <dbReference type="OrthoDB" id="1601230at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013097">
        <property type="entry name" value="Dabb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044662">
        <property type="entry name" value="HS1/DABB1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33178">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33178:SF10">
        <property type="entry name" value="STRESS-RESPONSE A_B BARREL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07876">
        <property type="entry name" value="Dabb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00886">
        <property type="entry name" value="Dabb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51502">
        <property type="entry name" value="S_R_A_B_BARREL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Stress-response A/B barrel" evidence="2">
        <location>
            <begin position="3"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM31102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="110" mass="11925" checksum="84572C0E464401FA" modified="2014-04-16" version="1">MSITHIVLFQFKPEVAAEVVHDACERMLGLKDSCVHPTSQKPYIKSASGGKDNSSEGIQNGITHAFVVEFASAADRDYYVQSDPSHLAFVKTLGGIIEKAQVIDFTNGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W6QP11</accession>
    <name>W6QP11_PENRF</name>
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        <submittedName>
            <fullName evidence="8">Ribosomal protein S13</fullName>
        </submittedName>
    </protein>
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        <name evidence="8" type="ORF">PROQFM164_S07g000074</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the universal ribosomal protein uS13 family.</text>
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    <dbReference type="EMBL" id="HG792021">
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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    </dbReference>
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        <property type="term" value="F:structural constituent of ribosome"/>
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        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="40S ribosomal protein S18"/>
        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="entry name" value="Rbsml_uS13_C"/>
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        <property type="entry name" value="Ribosomal_uS13-like_H2TH"/>
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        <property type="entry name" value="Ribosomal_uS13_CS"/>
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    </dbReference>
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        <property type="entry name" value="30S RIBOSOMAL PROTEIN S13/40S RIBOSOMAL PROTEIN S18"/>
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        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US13"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF00416">
        <property type="entry name" value="Ribosomal_S13"/>
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    </dbReference>
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    <keyword evidence="4 6 8" id="KW-0689">Ribosomal protein</keyword>
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        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
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        </source>
    </evidence>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM37726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="155" mass="17841" checksum="A586EE790C5BF60F" modified="2014-04-16" version="1">MSLVTGDKTNFQFILRLLNTNVDGKQKIMYALTQIKGVGRRYSNLVCKKADVDLTKRAGELTTEELERIVTILQTPTQYKIPSWFLNRQRDITDGKDTQVVSNGLDSKLREDLERLKKIRSHRGLRHYWGLRVRGQHTKTTGRRGRTVGVSKKKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W6QPD8</accession>
    <name>W6QPD8_PENRF</name>
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        <submittedName>
            <fullName evidence="4">Pleckstrin homology-like domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S04g000855</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
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        <property type="term" value="F:tubulin binding"/>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="PH_PLC_plant-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Nuclear_Pos-Cytoskel_Interact"/>
    </dbReference>
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        <property type="entry name" value="PH_dom-Mcp5-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28190">
        <property type="entry name" value="NUCLEAR MIGRATION PROTEIN NUM1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NUCLEAR MIGRATION PROTEIN NUM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12814">
        <property type="entry name" value="Mcp5_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PH domain-like"/>
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    </dbReference>
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        <property type="entry name" value="PH_DOMAIN"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1611"/>
            <end position="1722"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
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        </location>
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            <end position="1824"/>
        </location>
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        <location>
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        </location>
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        <location>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
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    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
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        </location>
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        <location>
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        </location>
    </feature>
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        <location>
            <begin position="1797"/>
            <end position="1808"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM35974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="1905" mass="209772" checksum="A0BBEF7F5A12A1FA" modified="2014-04-16" version="1">MPFEAPDSHIMTTSNAEATGPFASMDDPFVANSGRPTARRDSNRYSPFDSQLYSLNASSPAQAKRALEAHLAETERRLEEASRLGTALIDQQRQLSEQLKEVEQEQNEGEMGPELRRKLADLEKEYNEIGLESARAFLGPKRLAGGPEDAQLGTLSFDQKSPLNSALFASQATNSPSKVSVPSRKQRNQPSNRVHDIEFATEISTSLLAQVRQLQALLAERDETLKFVNLEKSRLELEAEGYEQRIRALDDSEQRYKDENWALETQAHEFMAAAREAAEREQRLNTTITLSNSEKNAAERELEELRQTNARLLEDQILTQKANDAEIHLLRRNLTSGDAEKAALQKKLLEMTSQNQELAKAVAMRLRDYENQNSRDIAYDDEDNEPEQITPESSPPPSPNKFTPRHGHLESETLKSSLGHAHRMIQSLKSTIHREKTEKIELKRMLQEARDEVEQRRRESTTVNATSKRQKTKTEPSRKPPRPDLLGAGRKEKSVVELNDTDWEDNAGQISPTETHTKALSTRGRSRSQSPDEPSDVYHTATEAEDGFETANEVATATESEAFQTGVESMADDSSDSADLTETENVQTTPRRRVPSPLLLAKARNRNSYNSTASASSDEEEYDKVFDSPSQRNASRPRVKSKRSVRRIRPSGEATFASTSRPSSSRESAAPSFAPLPLAQEGQSLFAELGELEDIDDDEVNSQASTPRMEPASGSRRPSDAMLDALPKPAMVDSGVMTEPWEPTSISTSIVAGAVGIAAGAALPHALAPDATQTDREIGEETKATPLKPSSDDPSNVSTPQNMLVGDRSVQDQQDDVNAQPDLPEMGIAHVSSQETTPSAPKRPDLSVAYITGGTTAPVKHVLPAPEVPEMTISSISSQTSHPIQPTVLVPEPIIKHVEVIKYVEREPEVPELTFSSITTQSTSPVQATVAVPEPIIKYVDVIKEVEREREVPELSLSSVAAQSTVPIQATVAEPEPVIKYVEREREIPELTLSSINNHSTVPVQATLAVPEPVVKYVDVIKHVEREREVPELSFSSVAAESTIPVQAIQATVPEPEPVIKYVDVIKHVEREREIPELGFSSINNQTTVPVQATLAVPEPIVTYVEREPEVPELTFSSITAQTTEPVQATVPEPQPPVIQYVDVIKHVEREREVPEASFSSITTQSTAPVHATLAKAEPIIEYVDVIKHVEREREVPELTFSSINNQSTAPVQATIAKAEPVIEYVDVIKHVEREREVPELTFSSITTQSTTPVEATVPEPEPPVIQYVDVIKHVEREREVPNLTISCLDPAYTKPIVPKPRLVPTPEFSFSSVRSVETHPAKSMPFVIPAVADLSTQTEPTESKAGAAIMVPGEQPVGATRSRPSTANSDQLAGAGLALNDISGNALPRSVRQQPSSVSMDQGSQTILSSKQIDQILMDRVSARPLSSDSQVTDSSREIASVTASITTPHVPPKAPTRPRLSQIQAAKPTTPSYRRPHSSASQTSGASHPPLPFDHREAITAAEKKSIDVAPPSPTSVMGPPLAPASAYRMNSQRPLTPSEHAARASSSRTGSSQARMRRGSQSQMSRRSSVSSFASELEERFNMAPQVGPMPQGYGPNTDPRMIQAITQTMIGEFLWKYTRKTGSSDMSTTRHRRYFWVHPYTRTLYWSTQDPQTAGKTELRTKSVPIEAVRVVADDNPYPPGLHCRSLEVVSPGRRVRFTATTSQRHETWFNALSYLLLRETNDTCEDNNSVSLDDINEFNPPSFRSSSRQNARLSFSSYNSRTARHASKQQRRAASAMSMRSSGTLGGRASPALSSPVPNSSLQVPDDRQRSSSRLSTISSSIRGSIASLKVRHGQSPSINDEILHGQESADDLRQVIETQEQDRLENVRACCDGKHDVGSLARTSRYSPRVNRMHSPHHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W6QPJ2</accession>
    <name>W6QPJ2_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">LYR motif-containing protein 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LYRM5</name>
        <name evidence="2" type="ORF">PROQFM164_S07g000260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I LYR family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792021">
        <property type="protein sequence ID" value="CDM37911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QPJ2"/>
    <dbReference type="STRING" id="1365484.W6QPJ2"/>
    <dbReference type="OMA" id="HRAFMSK"/>
    <dbReference type="OrthoDB" id="10258445at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090324">
        <property type="term" value="P:negative regulation of oxidative phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022904">
        <property type="term" value="P:respiratory electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20265">
        <property type="entry name" value="Complex1_LYR_ETFRF1_LYRM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045296">
        <property type="entry name" value="Complex1_LYR_ETFRF1_LYRM5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052000">
        <property type="entry name" value="ETFRF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21024:SF0">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN REGULATORY FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21024">
        <property type="entry name" value="GROWTH HORMONE-INDUCIBLE SOLUBLE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13233">
        <property type="entry name" value="Complex1_LYR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM37911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="85" mass="10352" checksum="9BC7C139B008E957" modified="2014-04-16" version="1">MVNLELRRQVINVYKELLFLGREYPLGYQYFRDRLHRAFASQTQITDDEQIRKGIARAEFVKKEVEALYYLKRYRTLKKRYGSEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W6QQU4</accession>
    <name>W6QQU4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S05g000282</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QQU4"/>
    <dbReference type="STRING" id="1365484.W6QQU4"/>
    <dbReference type="OMA" id="LMAICKK"/>
    <dbReference type="OrthoDB" id="4364700at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM36449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="299" mass="34247" checksum="CB97B849F209232B" modified="2014-04-16" version="1">MEEEDFLHLKAVWQNVESTNKSQAHIHLRLGAWFNKASQDLDNYPDFNRYLSAVQRRDAPSSRIGMFWAAYEQQCQVAKSLHATSKVKKAYGMNEELVNMSLVNFIQAVCACHPGLDINCNPARVHLTFDFRRVKDEKQAKAIDSRVHSLSCETDGLLESTATGRMYAILEAKARPRKKHEPKVSWQETAQMVTAALNERGTPKHLHPGRVILFSQDGDELYVSEATIRAGYIKHMKDERKAPTRVDEFVKVQQFGPYWIQLREDMQYFAKLVLAVALRASQEEATSVSEHRLRPREAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W6QRR7</accession>
    <name>W6QRR7_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WW-domain-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S05g000572</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QRR7"/>
    <dbReference type="STRING" id="1365484.W6QRR7"/>
    <dbReference type="OMA" id="SNRLEDH"/>
    <dbReference type="OrthoDB" id="1259151at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13214">
        <property type="entry name" value="PH-GRAM_WBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044852">
        <property type="entry name" value="WBP2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31606">
        <property type="entry name" value="WW DOMAIN BINDING PROTEIN 2, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31606:SF1">
        <property type="entry name" value="WW DOMAIN BINDING PROTEIN 2, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM36739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="228" mass="25217" checksum="475C1DA9B1620F58" modified="2014-04-16" version="1">MALNWVMLDDQGFVRLPNERLIYSSPPRTSVSLTPPSGYKGTEKLSVQSSAGCIHLTNQRVVYLPASRSDDFQSFSSPLLNVRDSHVSAPFFGPNVWTALVQPVSGGGISPSLPAVQLKVTFKEGGAFDFHTNFERIKERLEQAVENTGESTRGRQNVDLSAVHLEELPAYEAPPTPSHARPSETPEESENRRASDTSNEPMEPPPCYEEVQSQSVAHELEERLRRAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W6QRW3</accession>
    <name>W6QRW3_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ubiquitin-conjugating enzyme variant MMS2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">MMS2</name>
        <name evidence="3" type="ORF">PROQFM164_S05g000642</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QRW3"/>
    <dbReference type="STRING" id="1365484.W6QRW3"/>
    <dbReference type="OMA" id="GPESCSY"/>
    <dbReference type="OrthoDB" id="6508832at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006301">
        <property type="term" value="P:DNA damage tolerance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd23807">
        <property type="entry name" value="UEV_UBE2V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000026">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="2">
        <location>
            <begin position="6"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM36809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="139" mass="15532" checksum="6E59EA7405599DDE" modified="2014-04-16" version="1">MAAKVPRNFRLLEELEKGEKGLSADACSYGLADGEDMMMSNWNGTILGPPHSVHENRIYSVNIHCGPDYPDNPPTVQFVSRVNIPCVDPSSGKVDPTKLPTLAQWKRDNTMETVLIELRRYMALPQHKKLPQPPEGSTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W6QSE7</accession>
    <name>W6QSE7_PENRF</name>
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        <recommendedName>
            <fullName evidence="4">Flo11</fullName>
        </recommendedName>
    </protein>
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        <name evidence="2" type="ORF">PROQFM164_S05g000867</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM37034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1365484.W6QSE7"/>
    <dbReference type="OMA" id="ETIHYTL"/>
    <dbReference type="OrthoDB" id="5382203at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="427"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="538"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="810"/>
            <end position="1132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1145"/>
            <end position="1227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="556"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="597"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="668"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="689"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="711"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="739"/>
            <end position="748"/>
        </location>
    </feature>
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        <location>
            <begin position="766"/>
            <end position="779"/>
        </location>
    </feature>
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        <location>
            <begin position="880"/>
            <end position="892"/>
        </location>
    </feature>
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        <location>
            <begin position="896"/>
            <end position="913"/>
        </location>
    </feature>
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        <location>
            <begin position="938"/>
            <end position="950"/>
        </location>
    </feature>
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        <location>
            <begin position="1005"/>
            <end position="1024"/>
        </location>
    </feature>
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        <location>
            <begin position="1025"/>
            <end position="1038"/>
        </location>
    </feature>
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        <location>
            <begin position="1039"/>
            <end position="1049"/>
        </location>
    </feature>
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        <location>
            <begin position="1070"/>
            <end position="1085"/>
        </location>
    </feature>
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        <location>
            <begin position="1088"/>
            <end position="1097"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1106"/>
            <end position="1117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1163"/>
            <end position="1183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM37034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1227" mass="132506" checksum="93731DA2AE7FF36C" modified="2014-04-16" version="1">MQSFKTPDFLETGAVSRSRSPSVVSSDSQFSRVNLMSPPSVTPAPAFISPSAASDIVSADQEFNAADFVAEDEETGAGATALVTPAALSLLNGFLDNLLFNILASSKSTQLACIRSAMADVLKPRLAKEVVASAEEELGEYMGGADDEQTEFRGGQEPGGDFDLVRSWKLTRLRCMVYTRLGDMEEDDEDEFIAQDSLGETDGAPRRFSSHVDNITPAASIFLTSIIEYIGERALVIAGETSRSRLSAQLNNGGPEFGSGHERKRIDRLVVEDLDMEKLALNATLGRLWRTWRQRRRGTNLSRTLSRESFRPRGYSLANSRKSSIVTIEEPITPKEPLPVAMPPPLDPATVPLPTSHYDVQEIEVPGYTGDLDGEVQTMEAVIAHKVRPRSLMVFSSPSLVPKSPGSASISPVSTSAIEIGNPIRHVRTRSLPGGAPTPDFTEEEPEWPTDHPSPTASEKKQLETMYEDDESAEYVDAAETSPGIAITTEEEQEETPLMEPAEEASEIARMSILHEEEEETHPVGETVASLHAIAQAEDAMTDQSNSPRVSLVSLGDRRNQKDPEVIEGTGLCEKPKLTSTIHRPKRQPSKDASLLNAKSISEQTSDSELQAVAESQPSAQGVKTTPAPPAPPIEAITSCTDHDGTAPTRPSEEYTETAKSLSPDIICSTSGSGNSQLSKTRPRPSPLEVTTNNRSSSSSTVERAAVQRMSRPSSSITTKTRRSGSFGSAREKTRPVTAGSTTSQVSSRFKGIMNRPQGESEPPRMRSSSETSRASGGSVDSVEELADLDKLINSDETIHYTLTPRSVREMTFPKQPNRSVPRSETAGVSDLANFLNTTPPPGEDKHRPQTSVSSRATEEMSPISHTRSIDSPKHIPLTTRLTNMSSTSRSSKIGPARDARVPPSDSTRDFADFMKSTGPAGGVNEFKPSISAEGTRSVRPPSAVSSASRGNRPKLQARSAETKGSPTSDLIDFIREGPPMPAGAHRIPRTVAPFNALDSDDLQMETTTSSSFVSTGNESAPNKSLTSLGSRSGLLDSNQNKAPASTSAMDFDEPQPPVRKQRRAPDPYAIDDDDDDAYLEELLEQEQNPKPKREEESLMDFLLNAPPPSSEQPPQPFAVRAPASNNLSGASGMKARLLRTSHNSLRTQTAPTKVHSDYATKVGQQRNNGTLPSLSNRPTNTGDLADFLRNTGPPPAPARASSTPMGAKTKDGSFSRFFSRRKKVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2024-10-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>W6QSV3</accession>
    <name>W6QSV3_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S02g002728</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
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            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QSV3"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM32577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="26" mass="2775" checksum="DCBDBE5047B96FAB" modified="2014-04-16" version="1">MRAGIDSASILLLLLAVLVVKVGPYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W6QT86</accession>
    <name>W6QT86_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S06g000275</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792020">
        <property type="protein sequence ID" value="CDM37314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QT86"/>
    <dbReference type="STRING" id="1365484.W6QT86"/>
    <dbReference type="OMA" id="FGQNYGQ"/>
    <dbReference type="OrthoDB" id="4366053at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004879827" evidence="2">
        <location>
            <begin position="18"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="251"/>
            <end position="288"/>
        </location>
    </feature>
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        <location>
            <begin position="341"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="123"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="341"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM37314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="391" mass="39724" checksum="D651AD7ADEC29FB6" modified="2014-04-16" version="1">MVKTTYALTLFAAVSLAAPVAQLTGRAEAQGSVEHKNIIGDIPLLGPMLAGKQDAKRDEHHNLIDELPVIGKLLGNDKQNQRRDIGKDGISGLPIIGGLFGKHTHTGGENGMNKRRGVDQNYGQNAGQNEGENAGQNAGQNSGQNAGQNQGQNAGQNHDENKGQNEGQNGGQNAGQNGGKGLEDELESSLRGIPIVGNLLVNDQDKQKSGTPAKQLDTRQAGHSKGIFGVLQSLTSSGPVTKSHKRAEELEQLDSAAPNANETKQGAKKTAAEQAAKPSESSGGLLGGLMGKDGLGALKGNAHHGLGLLPMRRDQAPIEGSTLAGVLLEGGALGKVTNFLSGGAMPKPGSSSPSKIGDGSVAGPPDPASGAGPHSGPGLAGEQKQASGAAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W6QUT6</accession>
    <name>W6QUT6_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S03</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S03g000016</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QUT6"/>
    <dbReference type="OrthoDB" id="4526167at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM33292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="245" mass="27415" checksum="594B7E2BD87F089A" modified="2014-04-16" version="1">MPSSPRLAAKRRRPRYAGLLEDNALEKLQKISSLIDLRGYLKTDEARKVSEAFTLLSAHSEQSDSFQEFLIKVRDLSGPKQGNALVVLCVVAFGKYAIRSTREIIRLSLPRTIANMKEKFSTTVLEKIGEKHSKGLSQSDAPKPPQAEQNWPSASGSFAPRVPGNLYHPVLTPSPGSVPLDFQVKDLMNFLHEYQGPEKHLQMDCPVLGDTLPSIYLSRETDAKIEFSQTLAAAFVQYVMKHRQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W6QY64</accession>
    <name>W6QY64_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Carbonic anhydrase</fullName>
            <ecNumber evidence="5">4.2.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Carbonate dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PROQFM164_S03g001216</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Reversible hydration of carbon dioxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>hydrogencarbonate + H(+) = CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:10748"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="EC" id="4.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="4">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the beta-class carbonic anhydrase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.1" evidence="5"/>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QY64"/>
    <dbReference type="STRING" id="1365484.W6QY64"/>
    <dbReference type="OMA" id="ECGMSGL"/>
    <dbReference type="OrthoDB" id="10248475at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03379">
        <property type="entry name" value="beta_CA_cladeD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1050.10">
        <property type="entry name" value="Carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001765">
        <property type="entry name" value="Carbonic_anhydrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036874">
        <property type="entry name" value="Carbonic_anhydrase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43175:SF3">
        <property type="entry name" value="CARBON DISULFIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43175">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00484">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00947">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53056">
        <property type="entry name" value="beta-carbonic anhydrase, cab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="4">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR601765-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDM34492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="164" mass="18098" checksum="6D8638E3183E200B" modified="2014-04-16" version="1">MSVAKEFEAANAKYAASFTKGDLQLPPQRKTAVVACMDARLDPARALGLEEGDVHVIRNAGGRATDALRSVIISQQLLGTREIVIVHHTNCGMLTFTDEDLKDKIRADLHQNADHIAFLAFKDVEQSVRDDIKILKDSPLVLDVPITGYVYEVETGKIVRVEEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W6QZP8</accession>
    <name>W6QZP8_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">UDP-N-acetylglucosamine transferase subunit ALG14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">Asparagine-linked glycosylation protein 14</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">alg14</name>
        <name evidence="11" type="synonym">ALG14</name>
        <name evidence="12" type="ORF">PROQFM164_S03g001769</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Involved in protein N-glycosylation. Essential for the second step of the dolichol-linked oligosaccharide pathway. Anchors the catalytic subunit ALG13 to the ER.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 11">Heterodimer with ALG13 to form a functional enzyme.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Endoplasmic reticulum membrane</location>
            <topology evidence="1 11">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the ALG14 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM35042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QZP8"/>
    <dbReference type="STRING" id="1365484.W6QZP8"/>
    <dbReference type="OMA" id="FSMLRRM"/>
    <dbReference type="OrthoDB" id="37659at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043541">
        <property type="term" value="C:UDP-N-acetylglucosamine transferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004577">
        <property type="term" value="F:N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013969">
        <property type="entry name" value="Oligosacch_biosynth_Alg14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12154">
        <property type="entry name" value="GLYCOSYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12154:SF4">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE TRANSFERASE SUBUNIT ALG14 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08660">
        <property type="entry name" value="Alg14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="13"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDM35042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="276" mass="30715" checksum="A7BC4C7191DF905E" modified="2014-04-16" version="1">MSFSLASLSFGGLLLWCFVLAIALGASILLFLLISLTISQNIIPSKCRPRGSPTHLLVVLGSGGHTAEMLYMLERMNFDPQIYTYRTYLVSSGDNFSADKAKDFEAQHVQNSQGHTHNKNYTIVTVPRARRVHQSYLTAPFSTLRCFWACLNVLRGLHPDQRLPNEYNSLYPDLILTNGPATAVCVVAGAKLIRFFLCLAKCAALCLGLRTVSSFALAPKLRTIYIESWARVSSLSTSGVLLLPLADRFLVQWPAQAGRRAWWGMKRTQYAGWLVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W6R4R1</accession>
    <name>W6R4R1_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S05g000630</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6R4R1"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM36797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="96" mass="11313" checksum="AC9196C434A86BC6" modified="2014-04-16" version="1">MEHIEKFDLSKALPAISHPYEVSGEERIKKLEGYLKDESIKSQWSNIQFVINMYKTEKLRFLLRPPNGRSIYVCDGQVYHSLPDLEELWIDQCGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W6R6P3</accession>
    <name>W6R6P3_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S06g000464</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792020">
        <property type="protein sequence ID" value="CDM37502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6R6P3"/>
    <dbReference type="OrthoDB" id="5552418at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="100"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM37502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="165" mass="17984" checksum="59996672E6B50D70" modified="2014-04-16" version="1">MLYGFGQQGPTQGHFEVVPQYQTRQSAAIDVLSNQFAVPQYFAPEESAGSGVAGLSPYLNAQLQPYNQADPMARPNTTQTFSAPVSDFAAIGSGSMNRVDQPQQESQPSDQPSLDEAIGRYQRILCHTFDQTRAGRLVEAGGSLLEISEWLVTNARELGKMQSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W6R8A3</accession>
    <name>W6R8A3_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PROQFM164_S09g000013</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792023">
        <property type="protein sequence ID" value="CDM38097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6R8A3"/>
    <dbReference type="STRING" id="1365484.W6R8A3"/>
    <dbReference type="OMA" id="HRCYYES"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd20615">
        <property type="entry name" value="CYP_GliC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
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        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
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    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24303:SF31">
        <property type="entry name" value="CYTOCHROME P450 307A1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24303">
        <property type="entry name" value="HEME-BINDING MONOOXYGENASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0349">Heme</keyword>
    <keyword evidence="4 6 7" id="KW-0408">Iron</keyword>
    <keyword evidence="2 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="455"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM38097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="512" mass="59476" checksum="040A61F0E23F6B83" modified="2014-04-16" version="1">MGIAHGQLYRNTFRELPSQRGGSFAMEFFNPRIIYLFLGIVIIWKLYQRKDHVIDRIISTVLYPLRNEHGQNIKGPRWKYSDGQCLDKFLRGREASLEWRQYGPVYRICVITRPDDVKIFHSDSPSHLKSKSSNGGWLFHELLGDCMGLINGDRWEQVRAQFKHHFIHRSVSSISSHIELAATGYLQSLERQDAESFEVHAASDFSRFPFMTTAEYLYGPLTENEKEELWNLGQQSLALMGNVLSGGVYRFGLCQWMRPHSFRRLRSFQNQWQNFNQRLVNSRALSNNHQPPIVEAWMAMEKGCISMNEILQTLSEMLFANLDVSTHVLSWLIIFLAEDIDIQQQVRAEISANPGSLAELCGRKDTLLQFCFLESARLRPFTIFTIPESSPRTKIIGGYIIPSHTSVVVDTLAINYNQKFWGNDHSRFNPHRFQHLSSTELRYNLFTFGFGTRRCLGQHFAEAMLKHFVYHLLNRYEIDLPRLDAKKTWSSQPIQDTWVPIANARVILKPRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W6PRW3</accession>
    <name>W6PRW3_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S01g000757</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PRW3"/>
    <dbReference type="OrthoDB" id="4308432at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM26948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="146" mass="17062" checksum="CF15AEA0D5095985" modified="2014-04-16" version="1">MASKPQDSPSWITEDGSPLCGFYWMRIDPKVQPNYWVQPKKLCECWEHFPTQWPVDHVMIQIPACAFRCPYCTALDNVEKEGRPCPVRVKRHINAAHIRRQRDFYMGLQISFSGCFQSNAISTRSAVKRKSRPRAHIYNVHENRSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W6PRY3</accession>
    <name>W6PRY3_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S01g000782</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PRY3"/>
    <dbReference type="STRING" id="1365484.W6PRY3"/>
    <dbReference type="OrthoDB" id="4362161at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24322">
        <property type="entry name" value="PKSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24322:SF736">
        <property type="entry name" value="RETINOL DEHYDROGENASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM26973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="75" mass="8118" checksum="0FA2A64F9FA0E4AC" modified="2014-04-16" version="1">MFASNIADVASKVNPLAHYWLWQEFLSDTMEAKYGIVFTVALLAGLTVAHYVVDYLASKAAAISFHGGLVAELVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W6PS98</accession>
    <name>W6PS98_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Major facilitator superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PROQFM164_S01g000440</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PS98"/>
    <dbReference type="OMA" id="MFMAYFI"/>
    <dbReference type="OrthoDB" id="6509908at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF252">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="119"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="227"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="254"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="288"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="314"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="359"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="388"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="4">
        <location>
            <begin position="226"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDM26631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="417" mass="44312" checksum="8C5935492C408CD0" modified="2014-04-16" version="1">MGANGPTQESSLPAAPPNGGLAAWSGVFASFLLFVTTWGFSTAFGAFQSYYQSDLLRDSSPSRIAWVGTVSAFLLISTGAIAGPLFDRGYLHHLMIAGCFLTTLGLMMLSLSTEYYQVMLSQGVCVGLGSGLIYVPSLSLVSTLFTTRRGIAVGLVTSGASVGGVIFPVIFIRLQPSIGFPWTVRAMGFIQLACSCIAIPLLMATTKARHGAPRRLIHWHAFREWSFNAYAVANFFMFMAYFIPLFYLPTFASVALHTSTELSFYMVSILNAGSAFGRIGSSLLTPHLGASTVLLTSVLASAVILFGWTGIHSIPAFIVFCVLFGIFSGVLISANPLVIAHPIVSPTPSVIGTRMGMQWFATSLGVLIGAPIAGLIEGHGGDNGFLGLQIFSGMAMIVGAAFLLVPIMAIWRHDKPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W6PT33</accession>
    <name>W6PT33_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Isopenicillin N synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S01g000710</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PT33"/>
    <dbReference type="STRING" id="1365484.W6PT33"/>
    <dbReference type="OMA" id="QHVGFFY"/>
    <dbReference type="OrthoDB" id="406156at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.330:FF:000040">
        <property type="entry name" value="Chromosome 21, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00682">
        <property type="entry name" value="IPNSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Non-haem dioxygenase N-terminal" evidence="3">
        <location>
            <begin position="27"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="Isopenicillin N synthase-like Fe(2+) 2OG dioxygenase" evidence="2">
        <location>
            <begin position="202"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM26901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="373" mass="42741" checksum="73F311314FB50A32" modified="2014-04-16" version="1">MPGKYIEKYDQVPVTKEDLDWAELITLDLTQYDQPGGKEDLVKQLDHAVRNVGFFYVKNFNISQEEIDNQFALGREFYALPLEEKLKFHSASDLERGEYNSYRPAGHRILGNGIKDNVQVYNIPKFDGYHERPQPSVIAENIKEIETFSRKCHTEVVEKLLRLFAILLELPDEDQLVRDHQYDLKGEDHLRYMHYAARSAEDNKKVGELYSPGHTDLGTVTLLFRQPVAALQILNSEGQWKWVKPQDGTITINTCDALTALTGGLIKSSIHRVHAPPADQAHIDRLGVLYFARPNNHVILDPIQNSPLLQRLGLTTNAFTELGQHLTTEQWVKVRQTQQQRKNRDVKISSEGKYTYKPKDLEIIPGLQAAIYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W6PT34</accession>
    <name>W6PT34_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g001152</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PT34"/>
    <dbReference type="STRING" id="1365484.W6PT34"/>
    <dbReference type="OMA" id="QGMICED"/>
    <dbReference type="OrthoDB" id="8033832at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="299"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM27343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="450" mass="50667" checksum="ABE905BF2855ABB1" modified="2014-04-16" version="1">MEYHSVPPEERARDEDGNLLPWGYVYKDESRNPRRPPEESGPFGKRRNARYDNARSRTRTGTPAKRENPNVAEFGRLFSQQQQEAEKTHGLPKSSSSSSLDNPRKQTEKVATECILYGYKNKDNEWKVIEKFERISQGTICEDYPRNDPNSSINYTHLLSGGDVVIRNLSADANRKSKRYAGGYHWIKVTYDSTQSADRARFYSPQEIDGHLVFCELYNGHGPAEDAPIPADSVASSRIRNKAPRTLTTSHSTAFLSNPSKDQDRMTLPRSFAMNNLSSVPDMPEDERHSVDSSTVAGTSDDTMTSTTATSATATATPSFQQSSFNTTTSSSTWTTGASSSNDRASIHQRRAPDQAEPTANNEFMTHIPTVRRTKLRPMLEALPPQPTMTERILRSIPILSWFTGDIVGEGPVLREDGTFDSEKSGIYWRFWHTFDYFMRTDMCGLKEDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W6PTJ7</accession>
    <name>W6PTJ7_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fatty acid desaturase, type 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S01g001014</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PTJ7"/>
    <dbReference type="STRING" id="1365484.W6PTJ7"/>
    <dbReference type="OMA" id="DTVFVPW"/>
    <dbReference type="OrthoDB" id="1461976at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03507">
        <property type="entry name" value="Delta12-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012171">
        <property type="entry name" value="Fatty_acid_desaturase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32100">
        <property type="entry name" value="OMEGA-6 FATTY ACID DESATURASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
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            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <end position="125"/>
        </location>
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            <begin position="257"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid desaturase" evidence="2">
        <location>
            <begin position="74"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM27205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="395" mass="45009" checksum="4FFE1F8D5AABA09A" modified="2014-04-16" version="1">MAVTQRQPVKQAEQQTDIPSLQSLKDAIPKECFESSLTTSLLYLLRDSIYCAALIYAALHIHLLPSLPMRIVAWAVYGFFQGCVGTGLWILAHECGHGAFSKHQGINDFIGWATHSFLMVPYFSWKITHARHHRYTGHMEKDTVFVPWTEDDLASKRNVSVEQLKHLAEETPIVSFVQLIGHQLLGWQMYLILNVTAGTKSGPDGSEKVKFESHYNPSSAIFTAAQWKLIAYSDIGLLIMGSIVWYTGTIIGAWNVFFLYVVPYLWVHHWLIAITYLQHTHPEVAHYTAEAWTYTKGALATIDRTTGFIGRHFFHEIIDYHVVHHLFSRIPFYNAEKATKAIQPMLGENYHEQKDESFLYSLMVTFRKCIYVSESKGRASGQPGVLHFVLSDESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W6PU60</accession>
    <name>W6PU60_PENRF</name>
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        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S01</fullName>
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    </gene>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
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                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
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    <dbReference type="OrthoDB" id="2532734at2759"/>
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    </dbReference>
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            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM27286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="69" mass="7482" checksum="888C07F4CAE019A8" modified="2014-04-16" version="1">MPVIPESSDFPSAPEKGSNEAEKKPEKQTQKATAADFLSKGPQIPDNMPPKASKEELEARAKELNESSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W6PUR8</accession>
    <name>W6PUR8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Regulator of chromosome condensation/beta-lactamase-inhibitor protein II</fullName>
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    <organism evidence="3 4">
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        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
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                <person name="Renault P."/>
                <person name="Dupont J."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">FM164</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
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        <property type="entry name" value="Ub_ligase/GEF_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22870:SF408">
        <property type="entry name" value="OS09G0560450 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22870">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
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    </dbReference>
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        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="159"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="214"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM27635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="325" mass="34893" checksum="2729EB0AD36E81A3" modified="2014-04-16" version="1">MRLFAFGSNGSGQLGIGHEEDVSTPTQCLFEQPEPPQNTNLPDGSEIITIAAGGNHTLLLTTNGSIYAAGCNADGRCGPHKATKNPKEPESDNNGNILRFRQLIIPDAVSDTEVSKFKHVSATWEGTIAVASMPRRGSNNNNNNYNVIYGRNPNPDTEDRVFVFGSSPKGELGVGPDTPAPVPGICIPSFPPAGLRITALASGMAHSAAVLSNGDVYGWGAARKGQLGEENRGARIAYSPVRICVPFFAEAVACGREFTVVSGRGRFVVLGDRENRWGVLRIPESLSLRVDGGLGDHLRGEDEEGHFGMGFMYMLRLGWDGWNRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W6PUS5</accession>
    <name>W6PUS5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major facilitator superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PROQFM164_S01g001784</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PUS5"/>
    <dbReference type="STRING" id="1365484.W6PUS5"/>
    <dbReference type="OMA" id="AQNWPLR"/>
    <dbReference type="OrthoDB" id="9986881at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF31">
        <property type="entry name" value="POLYAMINE TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="172"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="206"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="230"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="264"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="296"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="372"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="409"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="450"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="479"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="508"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="545"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="141"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="12"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="28"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="67"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM27973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="604" mass="66643" checksum="52E845366D95D551" modified="2014-04-16" version="1">MDDQLPVIESHLSSEKPRTSAEIERRITSNSIGSSTGSSSSFEYDPQIHRLQSRNTELDLERHRTGTSRALSRTETQRAQHALTVGESLRSRPSRTPLPAFGGGKPYPPPLPEREDYVVEFDGPDDPLYPLNWSVKKKCYISAMLAFTSICSTFDSAVFSASSSNVSKHFGVSLEVAILSSSLYIVGYASGPLVWAPLSELQGRRIPILIAMFGFGVFNIGVAVAKDLQTLMICRFFCGMFGSCPLAVVAAVFSDIWDNRTRGVAIAIFSSTVFLGPLVAPFIGGFINMSYLGWRWTAYIPAIMGFSAFIMNLFFLRESYPPVVLVAKAAELRRRTKNWGIHAKQEEIEVDLRDLIVNNFSRPLRLLINEPLILAVTVYLSFIYGLLYCFLTAYTLVFQGVYGMNAGVGGLPLFGMVVGLFTAAAYIIISSKAYNKKLEMNGGVPIPEWRLPPVILGGGLFAAGLFWFGWAGFSGNVHWIVPTLSGLFTGFGLLVIFIQLFNYLIDTYLMFAASAIAANTFCRSMVAASFPLFSRQMFHGMGIQWAATLLGCVAAVLVPIPIGFYFFGKRLRMKSKFAPFYEAVQEGHAAEEADEQAEETVHQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W6PW10</accession>
    <name>W6PW10_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cell cycle control protein cwf14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">cwf14</name>
        <name evidence="4" type="ORF">PROQFM164_S01g001911</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the BUD31 (G10) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PW10"/>
    <dbReference type="STRING" id="1365484.W6PW10"/>
    <dbReference type="OMA" id="FGTSCIC"/>
    <dbReference type="OrthoDB" id="277109at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001748">
        <property type="entry name" value="BUD31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018230">
        <property type="entry name" value="BUD31/G10-rel_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19411:SF0">
        <property type="entry name" value="PROTEIN BUD31 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19411">
        <property type="entry name" value="PROTEIN BUD31-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01125">
        <property type="entry name" value="BUD31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00322">
        <property type="entry name" value="G10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00997">
        <property type="entry name" value="G10_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM28100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="148" mass="17161" checksum="3DA5F42CDBD0E95D" modified="2014-04-16" version="1">MPPIRTARNRKPPPAGFDDLEDTLLEFSNKMKDAENASHEGKKKYEVLWPIFQISHQRSRYIYELYYEKEAISKELYDFLLKNKYADANLIAKWKKQGYEKLCCLRCVQTKETNFNSTCICRVPKAQLKEDQTIQCVSCGCNGCGSSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W6PX31</accession>
    <name>W6PX31_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S01g002579</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1365484.W6PX31"/>
    <dbReference type="OMA" id="CHPDAFE"/>
    <dbReference type="OrthoDB" id="2546325at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF9">
        <property type="entry name" value="NACHT DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_2G01760)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="2">
        <location>
            <begin position="300"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM28768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="2038" mass="228619" checksum="11A5CCF1A3D9697D" modified="2014-04-16" version="1">MHTDMASVPHGISLSSTSLLGLRPTSNMAEQHATVAREKSFSHHYQQTTKNTTLADVVNSLARRGSDDLSASRVSDTDYASLLEWIRCERMRKLPPEGSGYDNALVWAALFIERVHSFDLAIEQFAGDSHLAAQLSYGYCASLLELGEENAPALMDLFGFFYRCSSGLGNLLDRAELFVVSSDIKDQLILALADLVTLVVCVATHFHRSLLASEWVSIDIYSTFPGPIDSFRGRCEHISDLMWRHQLIREGLEGDKAVGINTLKDWLQPEDPVVAHITEATAPSGQEREEATCTWVKPYLMRFLKGEKQVLSITSKSGSGKTVLSTVINDYLQYPVGGTRYMSILASIDGRIPANTTPGAVAKTIMSQMLSKRIGNLQLYQILAEAYNQSRLTVDEELYENLLWDALGRALKTSGAGSRELVLVVDGVDEASCGEKALSHRLHEAASKSPSLKLITLGSHPVDSVTSQMVVRVTLGLIFDDISAVTRKTLQQSHVYSKMSNEDKEVTVARIVEASDGSFLWAKLAAKRVRDENPPNEAALSKSVENIVQAGHKISDLISHTLQSKLSEDTKKILVWLVTANRPLAQQELAALLSTKPDEAALAEHREIDFPQLLKPVASLVFFHKNLVYLRHALVRTAILDVFSKGKFLPAIKDRHVDFAQRLLLYAKQTVTDSHGPSLEPLNGQVTEDLLRKHPLLDFALRYWTGYAKIAFKCTNNQEINIASKSFRSVLPATPSVPLLEMTLWASKATSLLRSIHEVQTSLYRQILSNNHPATVQAVICQALFFRQISNSVPAESSRIFYEAATICQKVLSVRNLITMQMAQFFLDATVDKMTDSVTEVMTRRIQILQMLVECQKVHHGATSSVVKSTLTQLSEHYSLVKEYRKVQEINENLERSFVNSTHQRSGSVQMDESLLVHLHGPKHTMPETSTPLDLTGIEVDELITNSFDLKTILTKAERQRAEGHFSDAERTYVELWQQTSQAYRLSHSTEHKVSVLRTVLEYSKFLKSRKRDNEAASILAGVWEEYEKTTSSAEALVSELLELAQFMKEVGLSVLALEVFKYCAQSTSSQSATRKEVERNIQSTSRQLMHSSSAKSLLTESTLKEMVYTSSSSDEQNFATASTALIEMYLSQHRWHDATRVLKRVLRDMWPSLFAASIEKVVLPSTNVEHCVDFAERLAGCYRYRRHPVKEEDIRTRLYSAVRRDRPVCGEQTVERATLNLLRLYERTSQTGKVVNIHQDMLDDYTKRFGGEHPTVIRQLWTLAELTAPQPIAVDYYRQIVQVLSKGWETCPPDAFEPLVIVATELLKQNRYADALKPCRMLFTTLQSPQISQKLRDPGFVQTIYQRYVHCLQMTHSDTTTIHDVTVQYRKSCITLFGASASITIQATNTLANICQESEQFEAEAVQLYEELLQIKSSEVEIDYQDIRATLDAIHEQQSAAFTTLKVENMSTKELQKTLSIHTQRLASIRSSYGWAHEEALSQMGEVVSLYTKQGKAQAAVSLLQEAAMQVLSTETLSIKLIAAAKSIASGYIAAGQIQKAEQLSNEIYRHVITKDTKDESALGFDRSSKGRSTLAFLAQFEYSIRECGDNSTTLNEIYAALTTEYIYFEQFRETLSSKTGKLQDTAETAARLHGFLLNRGRPSTATQVADRYTSFFLATEGSNLEIGPNQAKAFIETVLEYFSTHSSRDFMRSVAIASYNRVDQLLRSKDYQSACHIALAATKYIGAHHGYSSDATLKLVFKLGLLLAGQDNDIHPAGSADKYMLSVSATILRDTLEYFKEHNFELAHLDLEHINRLIKVLDEQQDYHTMAWVLTSLWNSRDAYALSQPRHSYTLALGRMLVITRYLISDYSGAVRLAEDLVYNCARVHGPRHPSTVEMTILLSQMYTSVAQGYQTQKSRRKLAYQYYRKAAALHENALRVFIDPSSAPASDVDMDVISGISSPSSASSPDENMEEGKHVRQHLHMLKLAVERLGNWPKEYSEYERLNRDLFSTFANDLKGVEGVEKWNLQSFGSGQAEASDDLVSFHHEHLAIPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>W6PX95</accession>
    <name>W6PX95_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Acetolactate synthase</fullName>
            <ecNumber evidence="4 12">2.2.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">ILV2</name>
        <name evidence="17" type="ORF">PROQFM164_S01g002644</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>2 pyruvate + H(+) = (2S)-2-acetolactate + CO2</text>
            <dbReference type="Rhea" id="RHEA:25249"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58476"/>
            <dbReference type="EC" id="2.2.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="12">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
        <text evidence="12">Binds 1 thiamine pyrophosphate per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 12">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 1/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the TPP enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.6" evidence="4 12"/>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PX95"/>
    <dbReference type="STRING" id="1365484.W6PX95"/>
    <dbReference type="OMA" id="QETDMIG"/>
    <dbReference type="OrthoDB" id="16262at2759"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00055"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00059"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005948">
        <property type="term" value="C:acetolactate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003984">
        <property type="term" value="F:acetolactate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd02015">
        <property type="entry name" value="TPP_AHAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07035">
        <property type="entry name" value="TPP_PYR_POX_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1220:FF:000008">
        <property type="entry name" value="Acetolactate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000007">
        <property type="entry name" value="Acetolactate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000053">
        <property type="entry name" value="Acetolactate synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012846">
        <property type="entry name" value="Acetolactate_synth_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039368">
        <property type="entry name" value="AHAS_TPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000399">
        <property type="entry name" value="TPP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045229">
        <property type="entry name" value="TPP_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme_TPP-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00118">
        <property type="entry name" value="acolac_lg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968:SF13">
        <property type="entry name" value="ACETOLACTATE SYNTHASE CATALYTIC SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968">
        <property type="entry name" value="THIAMINE PYROPHOSPHATE ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00187">
        <property type="entry name" value="TPP_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="11 12" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="8 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 12" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="6 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Thiamine pyrophosphate enzyme N-terminal TPP-binding" evidence="16">
        <location>
            <begin position="92"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme central" evidence="14">
        <location>
            <begin position="291"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme TPP-binding" evidence="15">
        <location>
            <begin position="499"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="31"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CDM28833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="694" mass="76465" checksum="CA3DA59C33B261AA" modified="2014-04-16" version="1">MMPLRPSKSALRAFHLQKQLAGRRPFSTSFVASAASPHRSSVQKRAQSTATASNPESRPVPSPSFNQEPHRNEISPLQHRQLPELDDSMVGMSGGEIFHEMMLRQGVKHIFGYPGGAILPVFDAIYNSKHFDFLLPKHEQGAGHMAEGYARASGKPGVVLVTSGPGATNVITPMQDAMSDGTPMVVFCGQVPTSAIGTDSFQEADVIGISRACTKWNVMVKSVGELPRRIQEAFEIATSGRPGPVLVDLPKDVTAGILRNPIPMHSTIPSLPSAATVAAREMSRKQLESTINRVAHLVNIAKKPVLYVGQGLLARPDGPMILKEFADKACIPVTTTLQGLGGFDELDPKALHMLGMHGSAYANMAMQEADLIIAVGARFDDRVTLSIPKFAPQAKLAATEGRGGIVHFEIMPKNINKVVQANEAVEGDCADNLRLLLPHVKAVSERPEWFEQINDWKKRFPLTLYDRQTEDGPIKPQAVIEKLSELTADRKEKTIITTGVGQHQMWTAQHFRWRHPRTMITSGGLGTMGFGLPAALGAKVARPDCLVIDIDGDASFNMTLTELSTAAQFNIGVKVLLINNEEQGMVTQWQNLFYEDRYSHTHQQNPDFVPLAKAMRVAADKCFKPSELEEKLKWLIDHDGPALLEVITDRKVPVLPMVPSGRGLHEFLVYDEAKDLERKELMRQRNVDFHVRKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W6PXW2</accession>
    <name>W6PXW2_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Subtelomeric hrmA-associated cluster protein AFUB-079030/YDR124W-like helical bundle domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g002899</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PXW2"/>
    <dbReference type="STRING" id="1365484.W6PXW2"/>
    <dbReference type="OrthoDB" id="5338458at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047092">
        <property type="entry name" value="AFUB_07903/YDR124W-like_hel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021264">
        <property type="entry name" value="AFUB_079030/YDR124W-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36102">
        <property type="entry name" value="CHROMOSOME 10, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36102:SF1">
        <property type="entry name" value="YDR124W-LIKE HELICAL BUNDLE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11001">
        <property type="entry name" value="AFUB_07903_YDR124W_hel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Subtelomeric hrmA-associated cluster protein AFUB-079030/YDR124W-like helical bundle" evidence="1">
        <location>
            <begin position="160"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM29088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="458" mass="51890" checksum="DD4169279956B1E9" modified="2014-04-16" version="1">MSSKLPSTSNVASQAPQDYAPAQHFALIYMDQYGTLHYEASPSIVHYRDTILSPQVTAEFLKAVANSTEVGLRRSSLEFASTQLFPDHLGNYDSHDSRFPKGIQAEGHDVPTTYGYHSQPHLWPGHDIATPAILKDKVLHKKRSCLQKHGLELQEAMLSIKDTKFLRRYYEKVFHNIQQTNCRVLAKAYVKCVEPHKQVNYPYNGRKTVAGEIRQLSSEQSKPPWWPPQVRHREPDHLLKAERIALLLHILCDLRCSHGVTSQKLKDAEQSVRSHIIPVERLELLDELYRVRGEEEKLLMGLLEKDAAVLISRINLPASNKIPSKQTQPDSWVSLKYKEGAATYESSSHKQDLYNVPIYPQRNFTGYTTRQEDMMDSFPVPAMSSTPLGKKRPMIDETYPSTAIFSPTHLVSSQCVTSHSLFVNLPVMEDVGPRLQNGPGLVHAEMALFADRTQICTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W6PYX2</accession>
    <name>W6PYX2_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Nucleoporin Nup186/Nup192/Nup205</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PROQFM164_S01g002742</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NUP186/NUP192/NUP205 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1365484.W6PYX2"/>
    <dbReference type="OMA" id="WSQMFAE"/>
    <dbReference type="OrthoDB" id="2019644at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044611">
        <property type="term" value="C:nuclear pore inner ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006999">
        <property type="term" value="P:nuclear pore organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021827">
        <property type="entry name" value="Nup186/Nup192/Nup205"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31344">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31344:SF0">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11894">
        <property type="entry name" value="Nup192"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="566"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDM28931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1665" mass="185756" checksum="F263A384EAD69D4B" modified="2014-04-16" version="1">MAELQDTRNGLRGLYQDLSALSNSQLPNVDRLCFELETHIQDFRKLLDKPAKNNASRQAVLSGKITVADVEYSVNQDFQQGALQLADALNIDELEAAVMFLTAQENSQVLDRPPLIAAIISFHERRLFTLECLRLIFRESREIEHEATHPIMHETLAHVLEIKNSPLRNASLFARKALSSMADIQKWLSLLGDQVQKASVVGQENDRDIMEAIEFQRTSLQQQHESLGAILFYMFKGTYTSCEDFRILVSQLKKIDRFDGLLFHYIPVTIVSFVQHGSPEGSGSEKEARDLHKLITTSKDGQGWKLSNFHAALVALWLSVYSGWYFDGLPSPSVDAEKESEERTKLFMSSLDDGALDFMLAICSSVNTEEWADPARSELVTLLLRESVVSLPDPEPCSSFMKELLMENLEVFVESCVANMPDAVRRLKSEEDSQRLDQITALRDGLTSNLHRGLVEVRTHLESLLMIISFAFEHRQEAAQEFWADPDGNLYGFLQWASKRQTVPRVSAFCEMLCSISEGEENAAAAHRFLSEEDKFMSSKFKRSTTMNWSQMFAELKLYASRVTEKPSTTTSPQGAPGIFRPRKPEPVEMNEPESPVMLTCYLRLIGHLCKQSRPIREWMLQNESFNVVSTLLDLCSGPIPSHLRATTFLTLSALMTDKCSPVGKETWARLDGWLSGGTGASGIGKVPLVSNPAVWHQQQALQKIGESFDQTNAFVVLINALTAPSSDSIDDPMSLPFPETLGGTYRMSGIEPYIDFILGHAFSRKIQELNEYQSRLLNFNCLDFVVASLKSFNEDLVLLLSQPSMSDSPTQTSSLLTYVRLHPFARVVDWLFNEDVLKSLFATSKQDVSDVATASPDSVLVLTLHRSLEVMNLLVDLQSTYFNIVKPLVHSQPVPSRTIVANSSLASFEDTVLNNLTLIPSLCLYCGTAHEQLTVISMALLEKLTSSRKLNKMTSPELVKWQSSNKIVEVLASEVDVDSISLPLVLQMEPDIRELDFGPNAAGYVIRESLLALLNTCLGTITDRPTVAHLLLGFDCVGNILDVSSEGLFANQSSLLHAIVNFLKAYPEILDGGIISWVVHLKRMAFEVLKHLWSSKLASYYTLGEMRAQAFLREMFAYQPIIGPSTAWNGFPIDSDEFWLTDAATALAEFLLYRSHLFTYAATEVRSTAKARSPALHAQILSVLLGNTLADNGEPLSSPSVFDLFDFADLDVGREFNMPQLYLLGDVALQLESKREEGVYSMEGVEEMIQMRKAELTANGPLRPHDEEQLLAEANDLKLFILATKQNSLIQINRYHALRSWVELVATMITCSSIDEGSRPAFILHSIQLILPKLTTAIEADLPEALELARLAELLIGRLASEPSATDASRSGDVIDEKLHQLFQLCIRGTNLATGNVLLRETLYSICSHYITRITSSDKGHENLRRLSQHVIKAAGSSLIETMCDDAYTGQESCRASALVLLNSLAVLDRQTDCVLAEFISRSNYLSLFLDALRSLPLELHNAQGSDTPALLAYYESLLSLLQRLSQTKGGANCVLNSGLFQAVHESRLFAADPDIGIDIENPDALQRYYDLLLSVLQVIVYAVFSRGIHNEQIKEQTRIFLAENRPCMVGIFKRSAKIGNTSTAHHETLCELVKTFMALVTATDFIEFEDQEVQHIARPALFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W6PZ53</accession>
    <name>W6PZ53_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S01g002822</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PZ53"/>
    <dbReference type="STRING" id="1365484.W6PZ53"/>
    <dbReference type="OMA" id="HEIVIDG"/>
    <dbReference type="OrthoDB" id="5330139at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM29011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="162" mass="17835" checksum="4197A3D877A31767" modified="2014-04-16" version="1">MAVFMFRNAVRPLSRALARDSPTRHFHHIATEFIALDATGRPVSEKVPVVIGNPGQAYVLISPSVGEAFRDASSTASTRDRCKLTFFHDTKHFGLTPSSYPRLHVPAQFPRQSDSNTSPATILLSGKMYEIVLDGTEDAEFAEHSSASGEYLKPVLDQLETM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q0B0</accession>
    <name>W6Q0B0_PENRF</name>
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        <submittedName>
            <fullName evidence="3">Probable transposable element</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S01g003532</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q0B0"/>
    <dbReference type="STRING" id="1365484.W6Q0B0"/>
    <dbReference type="OMA" id="PESWRIH"/>
    <dbReference type="OrthoDB" id="4365225at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056924">
        <property type="entry name" value="SH3_Tf2-1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24626">
        <property type="entry name" value="SH3_Tf2-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tf2-1-like SH3-like" evidence="2">
        <location>
            <begin position="19"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM29720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="144" mass="17465" checksum="4CB31CA5B75376FD" modified="2014-04-16" version="1">MRIKRQYNRYHRQIFFNIGDKVYLKLGHGYDTPLNQVLPRRLRQRYIGRFEVLERVRKLAYRLNIPTESRIHPVISIIYLEPAPDGDDPWERQPDDEHHPTTDERFPKDIVYEVDRILTKRVVNAPGRPRHNSTRHQITKYLIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q0L8</accession>
    <name>W6Q0L8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Histidine phosphatase superfamily, clade-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PROQFM164_S01g003628</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the histidine acid phosphatase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q0L8"/>
    <dbReference type="STRING" id="1365484.W6Q0L8"/>
    <dbReference type="OMA" id="WHEYNVF"/>
    <dbReference type="OrthoDB" id="258392at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050645">
        <property type="entry name" value="Histidine_acid_phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567">
        <property type="entry name" value="ACID PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567:SF142">
        <property type="entry name" value="PHOSPHOGLYCERATE MUTASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004879294" evidence="4">
        <location>
            <begin position="22"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="429"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="403"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="405"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDM29815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="483" mass="51225" checksum="7C3D923BAE8F67F7" modified="2014-04-16" version="1">MRYSIQSGLLLAASLSPVVDAERVLGAYIFARHGDRTPKVLGSTQLTDLGYREVFETGSFYNERYILSNSSKQIEGISADVVNPKQISASAPSDTVLQNSATGFLQGVYPPVGKVASQTLANGTSVEAPLNGYQLIQLIPATTSKNAEDSTWLQGSSGCQKATVSSNNYFFSEIYTSLLSSTKEFYQSLSPMLDSTFASSDMTFKNAYTIFDYLNVGNIHNSTSQFPHKSDLTDEVYHQLIALAGSHEFNLAYNSSDKVRAIDGAVLAGEILAGLNETITTKGTSKLSIGFGSYGTIFSLFGLLQMPAASVNFTGIPDYASSMVFELVTNASGTDFPTDKSDLSVRFMFHNGTITGSSEPTVYPLYGQSSELLSWDDFASKTKAIAVTSDDEWCTMCGNTDGKCASSDSTSSDSGSASTSSTGGSGMSLAVAGVIGAMVTLAVILGLQAIFFLLGGFRIAKRNKASPSPEVMSSSVMEAGKKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q0S1</accession>
    <name>W6Q0S1_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6987 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S02g000039</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM29890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q0S1"/>
    <dbReference type="STRING" id="1365484.W6Q0S1"/>
    <dbReference type="OMA" id="IGRAEPW"/>
    <dbReference type="OrthoDB" id="3937590at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022124">
        <property type="entry name" value="DUF3659"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054256">
        <property type="entry name" value="DUF6987"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39461">
        <property type="entry name" value="LEA DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_8G04920)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39461:SF1">
        <property type="entry name" value="LEA DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_8G04920)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12396">
        <property type="entry name" value="DUF3659"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22485">
        <property type="entry name" value="DUF6987"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6987" evidence="2">
        <location>
            <begin position="946"/>
            <end position="1144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="235"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="475"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="909"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="23"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="59"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="491"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="932"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="944"/>
            <end position="955"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM29890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="1155" mass="121823" checksum="7024AB2A43F239C9" modified="2014-04-16" version="1">MATPARPKAKPLGKAPSAPAKSATQKVPQAKQAKPTPPKLKEQRQKQAPEVEKPGTDASGSGSELSSLPSRGKAAAASPSGRLAKGAKDKAGAAKDKKPQDSLKAAKGATNKKDLPQADDTLNQQKVQDAAQTAKDKAPTDDLPQTDDVPKAGEVPEAPDISDNVPLDLSSLDGLEVGEGGKILDSNGNPIGEVVEGDPEGLVGQTVNSNGEIVDEDGDLIGRVDLIQQKAGELKDQGQEAAGLPQAGEVPEAPDISDKVPLDLSSLEGLEVGEGGKILDSNGNPIGEVVEGDPEDLVGQTVNGNGEIVDDDGDLIGRVDLIQQKAGELKDQGQEALGLSSLDGLEVGEGGKILDNNGNPIGEVVEGDPEDLVGQTVNENGEIINEDGDLIGRVDVIQQKAGELNDQAQDLSSLEGLEVGEGGKILDNEGNPIGEVVEGDPGDLAGQKVNDNGEIINEDGDLIGRVDLIQQKAGELKDQGQEAVGKSAEQPEGEEPDEQEDQAEPGEGVSLGAEPELPDISTLEGLTCNKLGSIVRADGTPVGELVEGDPKKLSRGGFQLDSEGQFWDNQGHVIGKAKPIEVEEEKPGLFSELGDIFVAEDSWIQDENGRKVGKLVEGDPKRLVGYAVDDDGDILDKRGNTIGRAEPWEEPEVEPEEVDFSSVEGLKPNKHGNVMGPDQVPIARVVEGELKEVAGRGINKKGEILNDDGEVIGKVQLIPKGERESLGPFSGLGELSVKESGYIEDADGEVVGRIVEGDPKSLRGQTVDISGEILDQYGNVNGRAERYEVPEEEEEEEDLSALEGGTVNKLGNVVDEHGTILGRIVAGNPKKLSGKKVDGNGQVWSDNGKVIGQAELIPEDEREKPEGIFFGLDGLTVGKEGMVMDPSGEVVGRLTEGDPQRLMGRAVDEDGEVIDKTGNVIGRAERYKPEEPEPEPEPELSPEEQEKQKKEKEDAELAKKMCTILQQTIDSVGPICKEITSRTEKASRTPKEELDEEQLVKDVKPLIEKAGNGLQECKGSLRALDPDGHIAATAKARSASHEATPEEYQLADLLKELTQTIVETIEKGREYISDMPHAKKKINPLWALLSEPLFQIIAAVGLLLSGVLGLVGKLLDGLGLGGLLKGLLGGLGIDKLIDGLGLGSVTGALGFEGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q131</accession>
    <name>W6Q131_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g001735</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q131"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM27924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="44" mass="4851" checksum="68E8CBABBE4D991B" modified="2014-04-16" version="1">MKLVSPIPNRTDKLNTASIHIHPHPHNKTPGESIPTQPSMCLPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q1B6</accession>
    <name>W6Q1B6_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">26S proteasome complex subunit SEM1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S02g000477</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the DSS1/SEM1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q1B6"/>
    <dbReference type="STRING" id="1365484.W6Q1B6"/>
    <dbReference type="OMA" id="TTQHLWE"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043248">
        <property type="term" value="P:proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd13768">
        <property type="entry name" value="DSS1_Sem1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007834">
        <property type="entry name" value="DSS1_SEM1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16771">
        <property type="entry name" value="26 PROTEASOME COMPLEX SUBUNIT DSS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16771:SF0">
        <property type="entry name" value="26S PROTEASOME COMPLEX SUBUNIT SEM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05160">
        <property type="entry name" value="DSS1_SEM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01385">
        <property type="entry name" value="DSS1_SEM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="61"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00034491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU369057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM30328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="87" mass="9782" checksum="BB466A197B573591" modified="2014-04-16" version="1">MSNPTTQKADATEQPAPQAKPQVLEEDDEFEDFPVEDWPQEEAEQANGSTANDGSEHLWEESWDDDDAAEDFSKQLQEELKKVEASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q1T0</accession>
    <name>W6Q1T0_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Altered inheritance of mitochondria protein 41</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">AIM41</name>
        <name evidence="2" type="ORF">PROQFM164_S01g001980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AIM41 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q1T0"/>
    <dbReference type="STRING" id="1365484.W6Q1T0"/>
    <dbReference type="OMA" id="RWNSTGP"/>
    <dbReference type="OrthoDB" id="538640at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016884">
        <property type="term" value="F:carbon-nitrogen ligase activity, with glutamine as amido-N-donor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1510.10">
        <property type="entry name" value="Uncharacterised protein YqeY/AIM41 PF09424, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003789">
        <property type="entry name" value="Asn/Gln_tRNA_amidoTrase-B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019004">
        <property type="entry name" value="YqeY/Aim41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042184">
        <property type="entry name" value="YqeY/Aim41_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28055">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 41, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28055:SF1">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 41, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09424">
        <property type="entry name" value="YqeY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89095">
        <property type="entry name" value="GatB/YqeY motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU365099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM28169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="179" mass="19563" checksum="B499B7BF2A4AB9FC" modified="2014-04-16" version="1">MFQSIRFSSRLPARLVRWNSTGPVLPPLMATLRTDLKTAMRAKDTTRLNVLRALISETNNAAKTSSPIQTDIQLLSLIRKRMNASKDAAKEFDAAERPDLKEKEDAQVLVLEEYASQVQTLPIADIKVVVIDQIAAMVNANTKPNPGTVLKALFAAGGPLDGKPVDRKEVATEVKNALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q2E9</accession>
    <name>W6Q2E9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Major facilitator superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PROQFM164_S02g000310</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q2E9"/>
    <dbReference type="STRING" id="1365484.W6Q2E9"/>
    <dbReference type="OMA" id="YKYGEWL"/>
    <dbReference type="OrthoDB" id="5296287at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF135">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="56"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="151"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="283"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="328"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="368"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="401"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="430"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="464"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="59"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="8"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDM30161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="498" mass="54014" checksum="689F3370811F9C0C" modified="2014-04-16" version="1">MNLSSNDETERTRIDVELKADEEAAKLPSHKLQDDVVDWDGPDDPKNPLNWPATKGFGHVVIVAILSMVVNIASTMVAPAMEGVARDLEITNMTLATFAVSIYLLGFALGPLVISSLSEMYGRLVVYHISNTLFVIFVVACAVSQTPAQFLVFRFLSGCAGAAPLSLGGGTIADVIPIEKRGAAAALFGLGPLLGPVLGPVIGGFVAEGKDWRWTFWVVAILGGAAGIGTLIFMRETHPNTLLERKAAYLRRTTGNLHLRSKLDRGLTKQQIIVAALVRPTKLLIFSPIVLVMSIYVALIFGLLYLLFATFSMVFEGQYGFSAGISGLAYLGLGIGELVGLVTFGILSDRILKSKMAVDNVQEPKPEYRLVLMMWFPPVIGPGLFIYGWTAYHQVHWMAPIFGTFIVGFGAFFVIMPSQLYLVDLFGSEAAASALGANILLRSMFGAFLPLAGSHMYSALNYGWGNTLLGFLALAFAPVPILFYRYGEWLRSRTTVTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q2Q5</accession>
    <name>W6Q2Q5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Acyltransferase ChoActase/COT/CPT</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PROQFM164_S01g002310</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carnitine/choline acetyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q2Q5"/>
    <dbReference type="STRING" id="1365484.W6Q2Q5"/>
    <dbReference type="OMA" id="HILVMRR"/>
    <dbReference type="OrthoDB" id="240216at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004092">
        <property type="term" value="F:carnitine O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009437">
        <property type="term" value="P:carnitine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.275.20:FF:000003">
        <property type="entry name" value="Carnitine acetyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.10:FF:000019">
        <property type="entry name" value="Carnitine acetyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.10:FF:000025">
        <property type="entry name" value="Carnitine acetyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.70:FF:000003">
        <property type="entry name" value="Carnitine acetyl transferase FacC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.20">
        <property type="entry name" value="Choline/Carnitine o-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.70">
        <property type="entry name" value="Choline/Carnitine o-acyltransferase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000542">
        <property type="entry name" value="Carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042572">
        <property type="entry name" value="Carn_acyl_trans_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039551">
        <property type="entry name" value="Cho/carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042231">
        <property type="entry name" value="Cho/carn_acyl_trans_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589">
        <property type="entry name" value="CARNITINE O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589:SF29">
        <property type="entry name" value="MITOCHONDRIAL CARNITINE O-ACETYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00755">
        <property type="entry name" value="Carn_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00440">
        <property type="entry name" value="ACYLTRANSF_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Choline/carnitine acyltransferase" evidence="9">
        <location>
            <begin position="93"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="11"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="433"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="615"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="53"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="615"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="634"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR600542-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDM28499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="851" mass="94074" checksum="A8F3F7E3AA18F571" modified="2014-04-16" version="1">MSYSSMAVRFFTAPKPLGDSLDTDPKPLGDPTDADPKPSSDSMDTGKSKKSGPDSQGQTVMRANISSEQPSAEIAEPKSQGLTFANQDSLPKLPIPDLENTCRRYLETLQGLQTPRDHEDTKAAVRDFLKNEGPILQERLKAYASSKTSYIEQFWYDSYLNFDNPVVLNLNPFFLLEDDPTPARNHQVTRAASLAVSSLAFVRAVRREELPPDTVRGTPLCMYQYSRLFGTARLPTENGCVISQDPTAKHIVVMARGQFYWFDVLDDNSDLIMSEKDISLNLEVIVEDATQTPLHEAAKGAVGVLSTENRKVWSGLRDIMTKDRRSNNAECLNIVDTALFILCLDATEPASMADLCTNMLCGTCEVVKGVQVGTCTNRWYDKLQIIVCKNGSAGINFEHTGVDGHTVLRFASDVYTDTILRFAKTINGQSPSLWATSSPDPAKRDPHSFGNVSTTPRKLEWDMTPELNIALRFAESHLSDLLCQHEIQVLDFECFGKNFITSMGFSPDAFIQMAFQAAYYGLYGRAENTYEPAMTKMFLHGRTEAIRTVSPECIDFVTAFWGENAAEQKVDALRIACQKHSAATKDCSKGQGPDRHLYALYCLWQRSFDEGLFPDTSSTGGYSSPGETQSQTQSQCPESPKLSSSSPSDDGFSSQGSSTRGYRTVTTPTPAIFADAGWDKINTTILSTSNCGNPCLRHFGFGPTSADGFGIGYIIKDDSISICASSKHRQTSRLMHTLETYLFEIRKLLRATNRKATSPRTSRARETEAFAEILQAETNRRGRLVRGGGVETPTSAAESSYMEDDGMGGYGFFDAGMLLHALKGLSAEREQRGEKSVRRRFVGKKLHLNDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q3S4</accession>
    <name>W6Q3S4_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">cAMP-dependent protein kinase regulatory subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">pkaR</name>
        <name evidence="11" type="ORF">PROQFM164_S01g002575</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM164</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">Tetramer, composed of 2 regulatory (R) and 2 catalytic (C) subunits. In the presence of cAMP it dissociates into 2 active monomeric C subunits and an R dimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cAMP-dependent kinase regulatory chain family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q3S4"/>
    <dbReference type="STRING" id="1365484.W6Q3S4"/>
    <dbReference type="OMA" id="WSPPHHP"/>
    <dbReference type="OrthoDB" id="417078at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005952">
        <property type="term" value="C:cAMP-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030552">
        <property type="term" value="F:cAMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004862">
        <property type="term" value="F:cAMP-dependent protein kinase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034236">
        <property type="term" value="F:protein kinase A catalytic subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033554">
        <property type="term" value="P:cellular response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000039">
        <property type="entry name" value="cAMP-dependent protein kinase regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000006">
        <property type="entry name" value="cAMP-dependent protein kinase type I-alpha regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050503">
        <property type="entry name" value="cAMP-dep_PK_reg_su-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018488">
        <property type="entry name" value="cNMP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11635">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE REGULATORY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11635:SF152">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00103">
        <property type="entry name" value="CAMPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00888">
        <property type="entry name" value="CNMP_BINDING_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00889">
        <property type="entry name" value="CNMP_BINDING_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0114">cAMP</keyword>
    <keyword evidence="4" id="KW-0116">cAMP-binding</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="10">
        <location>
            <begin position="160"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="10">
        <location>
            <begin position="292"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="80"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="36"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="87"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="119"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDM28764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="417" mass="44833" checksum="7707844BFB1EDBD4" modified="2014-04-16" version="1">MALNSAPDLAPAVNTRVDDNSAGNQKNSEDDGFEVTSPTNLTFRQPNSGAALPSAALFGGSAFAEGGSQGLQVGRSLFSRSPFQDNAGEDDEEEGELAPLPERSAQQGFPTNYALGRRTSVSAESLNPTEAGSDSWSPPHHPKTEEQASRLKSAVSSNFLFSHLDDDSFSTVLNALVEKPIPAKDIKVISQGDAGDYFYIVEKGNFDVYINPSGAVQPGPDGLGNKVASTGPGGSFGELALMYNAPRAATVISTEPQSTLWALDRVTFRRILMDSAFQRRRMYEAFLEEVPLLSSLKPYERSKIADALDTIKYPANSIIIHEGDPGDAFYLLESGEAEATKNGVSGPVKSYHRGDYFGELALLDDKPRQASITTKTDVKVARLGRDGFKRLLGPVEGMMRGAEYELDGEKSPVSKPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q3V7</accession>
    <name>W6Q3V7_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cystinosin/ERS1p repeat</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PROQFM164_S01g002615</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q3V7"/>
    <dbReference type="OMA" id="FVIYFPR"/>
    <dbReference type="OrthoDB" id="19344at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051415">
        <property type="entry name" value="LAAT-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201:SF11">
        <property type="entry name" value="PQ-LOOP REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201">
        <property type="entry name" value="SEVEN TRANSMEMBRANE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00679">
        <property type="entry name" value="CTNS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="84"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="138"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="169"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="234"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="268"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM28804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="307" mass="33221" checksum="8C58496A93582C73" modified="2014-04-16" version="1">MDSLTPYCRELASPGIFQTALSIQIILGILLSYLPQHIRIIARRSSFGISPYFILLGVTSGTSAFANILVFPSTAQDVACCRDISGFACFAGLLGVFQMAMQWLAFFSILLLFVIYFPRATSPTDPVGSVSSTSNGPTYRTALIVTGICLLHALVTIIISLAVELRYPAAVATWANFLGILAAILASIQYFPQIYTTFRLRCVGSLSIPMMCIQTPGSLVWAASLAARKGWSGWSIWGVLVVTACLQGTLLTMAIYFEYFGSNNKGKAGHVDQTGEPDESAPADESAQQEPVHEERPSEETPLLQSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q402</accession>
    <name>W6Q402_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DUF1753-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S02g001225</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q402"/>
    <dbReference type="STRING" id="1365484.W6Q402"/>
    <dbReference type="OMA" id="DQPVGFN"/>
    <dbReference type="OrthoDB" id="3338076at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070916">
        <property type="term" value="C:inositol phosphoceramide synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070917">
        <property type="term" value="F:inositol phosphoceramide synthase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006673">
        <property type="term" value="P:inositol phosphoceramide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013862">
        <property type="entry name" value="Kei1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28077">
        <property type="entry name" value="INOSITOL PHOSPHORYLCERAMIDE SYNTHASE REGULATORY SUBUNIT KEI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28077:SF1">
        <property type="entry name" value="INOSITOL PHOSPHORYLCERAMIDE SYNTHASE REGULATORY SUBUNIT KEI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08552">
        <property type="entry name" value="Kei1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="16"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="90"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="183"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="286"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="315"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM31075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="344" mass="38131" checksum="8F1D319E44A9B1A6" modified="2014-04-16" version="1">MGFASRFLRIPRPESFFYLMSLETGASLITLSLLLNKISGLYGLLALLTGYHLSPVQLSMYLWSLIALGLASLLFPHIRKQSPLQCLALTYLYVFDSLINAAYTAAFGVTWFLVVSQHYDSGNAAGPGGETIAETAGFTSPKYDAAYVEIQNTKEGNNFIAHPPRSAEDFSNVVLQPESLPSIIFICLLWVIRVYFVLVMLAFARQALRLWVAVPRHTQLPTHSRNVSVASVADIDREPFSPYSPDGQGWEGKLGRVMISIGHSYWLGEEEDGNWLSGINHKFRNRSGNTELPGALERERRRRSGTGPPTPSPSIVRSTVLQQPIAETTPAGMNVKMQDWTAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q496</accession>
    <name>W6Q496_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S02g000901</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q496"/>
    <dbReference type="STRING" id="1365484.W6Q496"/>
    <dbReference type="OMA" id="STCRCVS"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="604"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="647"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="69"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="611"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="647"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="683"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="717"/>
            <end position="726"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM30751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="748" mass="84111" checksum="04A4E528049B7C19" modified="2014-04-16" version="1">MQGLWSRTVSKQSSCRCVGCLSTTTNGVTSRAATSSKRRLRIGNSVTAFYGSIFAGAAIADASVKDRRRHDWEEKIAAVKAEVSELVDEEERILASLQSRRETRGLNRLIQARGFGTVACFPPGTQFPTSFNRIRAFHTERTRLNAAGARLVENKPVEEDEHTIDEQDESEIFLPQETLPSWVLEDDLRLKAIQKLALRQFAIRILLRPAIAHRYSGVSMNYAADFETPQVNVAQLLEELNRLRHRMNTLKTNRHATYSDITQDYAASQLGEMQREREALDAELTNDIRIYTSQEMPLQELLLRISNNILSSRDPDRPTAFRVMIMAFGQTRQNDLVELLLRTLLPNRFFLNPSLVITIITFFRKSKNLKDFDLFLKMLGGEGYSVNLGSRGVYKHRTVNGMDLIVPSLNSSNPVIYAALIAAALRFDQPDRADAWLQAARGGGFFDSWETLFTYLRFYSLRRDWDKGVNVLRRAVTYLLSSTDHRVDSVERLLGRMVGLCDSCDKLDASDALVKAAVHSGFDPRLISRQSDSGPFVHGDHKRWSNAAKQTPRENIDRPLWQKCYDFGNTFGEYLSQIEVPVEDTFARRNAKLADQHAENALFTALGRSRTPASSEGKTPAGNTANEDISTLKGEVAQLRELIYELRKHHISDPSTKDSSRTPTSEETLPPPAETITTITTLKNPQPQTPPLSRNFTRTSTRISLAKSQVASSSPRKSSKRSRRRQTSTDQPSLERTAPGAEPAVFAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q5Z4</accession>
    <name>W6Q5Z4_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF3500 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S02g002274</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q5Z4"/>
    <dbReference type="STRING" id="1365484.W6Q5Z4"/>
    <dbReference type="OMA" id="TRIMQIE"/>
    <dbReference type="OrthoDB" id="4539697at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021889">
        <property type="entry name" value="DUF3500"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37489">
        <property type="entry name" value="DUF3500 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37489:SF1">
        <property type="entry name" value="DUF3500 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12006">
        <property type="entry name" value="DUF3500"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM32123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="427" mass="48837" checksum="6D7BBB133EEB3031" modified="2014-04-16" version="1">MANASKNTTGEYRQYLPDLNIPRFQAMCQQDAHEYANEFKTGHQPPWLHALYMHWLELFQEPFKGVTTDGNVRPGLFTLQEEDVPIQQIVDAAEAVTSLLDDKQKEAINYHIDSPQWRTWSNPEFLLADKGIRLDEVTPETRDAVMNVLKTTLSPEGYEKAVSAMRINHFLGELVKSPAVMNEFSYNFVLFGRPSITRPWGWSFYGHHLCLNVFLYKGQIVASPWFTGAEPNEIDAGPYAGTRILQIEEKLGLQLMQSLSAELQASARVFAHMKDPAMPPGRWNKDDQRHLCGAYRDNREVPYEGILVSSFSTAQKQLVYGILEQYLLYLPAKSRAMKINQVRAHEAETYFCWIGGYGDEDPFYYRIQNPVILVEFDHHSGVFLNNEEPKKFHIHTLLRTPNGGDYGQALRPLIPAIEGLNGKEIVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q660</accession>
    <name>W6Q660_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S02g002349</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q660"/>
    <dbReference type="OMA" id="NCHICHT"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM32198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="52" mass="5508" checksum="BF5E11B212D9B35E" modified="2014-04-16" version="1">MCSFTKCAAPVCSNSAVITKMPGVRCPNCQAQGKEVWVIPGKNCHICHTPCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q6B7</accession>
    <name>W6Q6B7_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Clr5 domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S01g003627</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q6B7"/>
    <dbReference type="STRING" id="1365484.W6Q6B7"/>
    <dbReference type="OMA" id="MPRQQIN"/>
    <dbReference type="OrthoDB" id="5392716at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025676">
        <property type="entry name" value="Clr5_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14420">
        <property type="entry name" value="Clr5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Clr5" evidence="2">
        <location>
            <begin position="7"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM29814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="151" mass="17824" checksum="856436345CE9C928" modified="2014-04-16" version="1">MPRQQINLEPYRDDIITLYHHGISSDSISRTLESCHNIQVKERTIQSRLRKWGIRKRHRTTTGDEALHARIKMLFIQDRLTDKAMLNMLQKEGYAISERTLRRLRFKLGLHARASDQEQHQHQEQDQMQKQMIVPQPRAEGTAGVNLTCWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q6K2</accession>
    <name>W6Q6K2_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sulfate adenylyltransferase</fullName>
            <ecNumber evidence="9">2.7.7.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ATP-sulfurylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Sulfate adenylate transferase</fullName>
            <shortName evidence="9">SAT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">met3</name>
        <name evidence="9" type="synonym">MET3</name>
        <name evidence="13" type="ORF">PROQFM164_S02g002474</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the first intracellular reaction of sulfate assimilation, forming adenosine-5'-phosphosulfate (APS) from inorganic sulfate and ATP. Plays an important role in sulfate activation as a component of the biosynthesis pathway of sulfur-containing amino acids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>adenosine 5'-phosphosulfate + ATP = 3'-phosphoadenylyl sulfate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24152"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58243"/>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.25"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>sulfate + ATP + H(+) = adenosine 5'-phosphosulfate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:18133"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16189"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58243"/>
            <dbReference type="EC" id="2.7.7.4"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="9">Allosterically inhibited by 3'-phosphoadenosine 5'-phosphosulfate (PAPS).</text>
    </comment>
    <comment type="pathway">
        <text evidence="9">Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate: step 1/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8 9">Homohexamer. Dimer of trimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="9">The adenylyl-sulfate kinase (APS kinase) is non-functional. It is involved in allosteric regulation by PAPS. PAPS binding induces a large rotational rearrangement of domains lowering the substrate affinity of the enzyme.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">In the C-terminal section; belongs to the APS kinase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">In the N-terminal section; belongs to the sulfate adenylyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.4" evidence="9"/>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q6K2"/>
    <dbReference type="STRING" id="1365484.W6Q6K2"/>
    <dbReference type="OMA" id="MEMRYAG"/>
    <dbReference type="OrthoDB" id="468at2759"/>
    <dbReference type="UniPathway" id="UPA00097"/>
    <dbReference type="UniPathway" id="UPA00140">
        <property type="reaction ID" value="UER00204"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004020">
        <property type="term" value="F:adenylylsulfate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004781">
        <property type="term" value="F:sulfate adenylyltransferase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019344">
        <property type="term" value="P:cysteine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070814">
        <property type="term" value="P:hydrogen sulfide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010134">
        <property type="term" value="P:sulfate assimilation via adenylyl sulfate reduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019379">
        <property type="term" value="P:sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02027">
        <property type="entry name" value="APSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00517">
        <property type="entry name" value="ATPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.400.10:FF:000003">
        <property type="entry name" value="Sulfate adenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000802">
        <property type="entry name" value="Sulfate adenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000052">
        <property type="entry name" value="Sulfate adenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.400.10">
        <property type="entry name" value="Sulfate adenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03106">
        <property type="entry name" value="Sulf_adenylyltr_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002891">
        <property type="entry name" value="APS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059117">
        <property type="entry name" value="APS_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025980">
        <property type="entry name" value="ATP-Sase_PUA-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027535">
        <property type="entry name" value="Sulf_adenylyltr_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050512">
        <property type="entry name" value="Sulf_AdTrans/APS_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024951">
        <property type="entry name" value="Sulfurylase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002650">
        <property type="entry name" value="Sulphate_adenylyltransferase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00455">
        <property type="entry name" value="apsK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004040">
        <property type="entry name" value="PRK05537.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00339">
        <property type="entry name" value="sopT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42700">
        <property type="entry name" value="SULFATE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42700:SF1">
        <property type="entry name" value="SULFATE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01583">
        <property type="entry name" value="APS_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01747">
        <property type="entry name" value="ATP-sulfurylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14306">
        <property type="entry name" value="PUA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword evidence="2 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="6 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 9 13" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ATP-sulfurylase PUA-like" evidence="12">
        <location>
            <begin position="4"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="Sulphate adenylyltransferase catalytic" evidence="11">
        <location>
            <begin position="174"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="APS kinase" evidence="10">
        <location>
            <begin position="395"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal" evidence="9">
        <location>
            <begin position="1"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Allosteric regulation domain; adenylyl-sulfate kinase-like" evidence="9">
        <location>
            <begin position="395"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="198"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="199"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="200"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="197"/>
            <end position="200"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:16189"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:16189"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="291"/>
            <end position="294"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:16189"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="333"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="434"/>
            <end position="437"/>
        </location>
        <ligand>
            <name>3'-phosphoadenylyl sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
            <note>allosteric inhibitor</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="515"/>
        </location>
        <ligand>
            <name>3'-phosphoadenylyl sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
            <note>allosteric inhibitor</note>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="9">
        <location>
            <position position="203"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="9">
        <location>
            <position position="206"/>
        </location>
    </feature>
    <feature type="site" description="Induces change in substrate recognition on ATP binding" evidence="9">
        <location>
            <position position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00062002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF14306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDM32323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="573" mass="64083" checksum="AFC0AF086EA00B2B" modified="2014-04-16" version="1">MANAPHGGVLKDLLARDAPRHAELAAEAETLPAVTLTERQLCDLELIMNGGFSPLEGFMNQADYDRVCEDNRLADGNVFSMPITLDASKKVIEENKLQAGTRITLRDFRDDRNLAILTIDDIYRPDKTREAKLVFGGDPEHPAIVYLNNSVEEFYIGGKIEAVNKLNHYDYVALRYTPAELRVHFDKLGWSRVVAFQTRNPMHRAHRELTVRAARSRQANVLIHPVVGLTKPGDIDHFTRVRAYEALLPRYPNGMAVLGLLGLAMRMGGPREAIWHAIIRKNHGATHFIVGRDHAGPGSNSKGEDFYGPYDAQHAVEKYKDELGIEVVEFQMVTYLPDTDEYRPVDQVPAGVKTLNISGTELRRRLRSGAHIPEWFSYPEVVKILRESNPPRATQGFTIFLTGYMNSGKDAIARALQVTLNQQGGRSVSLLLGDTVRHELSSELGFTREDRHTNIQRIAFVATELTRAGAAVIASPIAPYEESRKFARDAVSQAGSFFLVHVATPLEYCEKSDKRGIYDAARRGEIKGFTGVDDPYETPDKADLVVDFSKQSVRSIVHEIILILESQGFLERI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q6K7</accession>
    <name>W6Q6K7_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Mating type protein [Penicillium chrysogenum]</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PROQFM164_S02g002484</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q6K7"/>
    <dbReference type="STRING" id="1365484.W6Q6K7"/>
    <dbReference type="OMA" id="REHAIKH"/>
    <dbReference type="OrthoDB" id="6247875at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01389">
        <property type="entry name" value="HMG-box_ROX1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.30.10:FF:000041">
        <property type="entry name" value="HMG box family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050140">
        <property type="entry name" value="SRY-related_HMG-box_TF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10270:SF161">
        <property type="entry name" value="SEX-DETERMINING REGION Y PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10270">
        <property type="entry name" value="SOX TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HMG box" evidence="5">
        <location>
            <begin position="131"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="4">
        <location>
            <begin position="131"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDM32333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="293" mass="33387" checksum="3A4D5F0DEBB09910" modified="2014-10-29" version="1">MANTLFELVGEDDDMSPRRTMELLWADAVAHLPQTDGEVFLPRNVVDDVLDMDLLMDMATRLASMLNKKVDIVLDESIDAYRMFPKHIAAENDEDVWVESHGLELDDHRRISKSIYNAGSSVKLPVRPAKVPRPPNCFILYRQANHHLVKDANPGVSNNEISRILGARWNNESPEIREQFTRLADDLKREHAIKHPDYQYAPRRPSERKRRTPRARASCLPVAQEDSNYVDVDDQLMTIDDKFMSELHSNGYLFGPNGVEPVSAPFTNEECLEMSNELLSGNVLASLPYIPMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q703</accession>
    <name>W6Q703_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Probable cytosolic iron-sulfur protein assembly protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">cia1</name>
        <name evidence="3" type="synonym">CIA1</name>
        <name evidence="6" type="ORF">PROQFM164_S02g000193</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Essential component of the cytosolic iron-sulfur (Fe/S) protein assembly machinery. Required for the maturation of extramitochondrial Fe/S proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat CIA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q703"/>
    <dbReference type="STRING" id="1365484.W6Q703"/>
    <dbReference type="OMA" id="IREIRWS"/>
    <dbReference type="OrthoDB" id="284782at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097361">
        <property type="term" value="C:cytosolic [4Fe-4S] assembly targeting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03037">
        <property type="entry name" value="ciao1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028608">
        <property type="entry name" value="CIAO1/Cia1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19920:SF0">
        <property type="entry name" value="CYTOSOLIC IRON-SULFUR PROTEIN ASSEMBLY PROTEIN CIAO1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19920">
        <property type="entry name" value="WD40 PROTEIN CIAO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="57"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="139"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="186"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="430"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="101"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDM30044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="446" mass="49337" checksum="1C4CAAFFFE909917" modified="2014-04-16" version="1">MSPNVTITHLSDLTPPSQERTWLTAPHPTLPIVATCSSDKTIRVYSLTNFTLLSTITGGHKRSVRTAAWKPHMSGESVLATGSFDATVGIWRRWDNYGREDGAGMGMTNDNNQTPTDTSDADSADREEDEEEWRFAVLLDGHDSEVKSVSWSASGMLLATCSRDKSIWIWEDLDDGDNNFETVAVMQEHSGDVKCVSWHPSEECLASGSYDDTIRLWREDLDDWGQVACIKGHGGTVWFLDWEGDDAEKWNGPISDSNSESELSALQAQWRSQRALSGPRLISCSDDRTVRVWRRQPKESQQMGAFSSATTGIPSIIRPTGTDEAWEEDAVLPHAHELPVYAVAWSKRTGLVASTGADGRIAIYEERFVTPEKEEKQDDADAMDTASSDVLRTEWVLVGIQDGAHGIYEINHVAWAKRADRGSGGEEEVLVSTADDGSVKVWTVTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2024-10-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q729</accession>
    <name>W6Q729_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S02g001912</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q729"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM31761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="49" mass="5343" checksum="46F76ED2B562A721" modified="2014-04-16" version="1">MCDILGCTSNPHDSSMWKQGLFYVGECGVGKGHIIRAIIAATVLVHRKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q769</accession>
    <name>W6Q769_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">MICOS complex subunit MIC12</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">Altered inheritance of mitochondria protein 5, mitochondrial</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9 11">Found in mitochondrial proteome protein 51</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PROQFM164_S02g000253</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 11">Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Mitochondrion inner membrane</location>
            <topology evidence="11">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the MICOS complex subunit Mic12 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q769"/>
    <dbReference type="OMA" id="AYESRWE"/>
    <dbReference type="OrthoDB" id="4037694at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061617">
        <property type="term" value="C:MICOS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044284">
        <property type="term" value="C:mitochondrial crista junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042407">
        <property type="term" value="P:cristae formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031463">
        <property type="entry name" value="Mic12"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17050">
        <property type="entry name" value="AIM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDM30104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="125" mass="14693" checksum="18FC79532E42D25C" modified="2014-04-16" version="1">MGFFTGFLGGFAFTSSVLCITIQVHRSTRISQRNAIHAQVEQIDWLNSSAGAYDRRFLPEDVPRWRREELEAQRQAEPTMKEIFKHRWNKEVEALTRKAYETRWEDVRHAAAESWKAAARVVKRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q7B2</accession>
    <name>W6Q7B2_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S02g002769</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q7B2"/>
    <dbReference type="OrthoDB" id="10473932at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM32618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="162" mass="18179" checksum="CFD72745D4750B67" modified="2014-04-16" version="1">MELVPEGWGLGTVARDWGSSRGEYEARTEEPMSDVSNQRPPATLKIIASSLCIALNGHRKCCSPFTLHGPSGPLCRTSEQDDFPRFTRCGCYIEATRHTTYDRAMALIASIARNETYIEVHATANCYCKCRVMTVDTLQLNCRRILKEAAREGGPEKAFRWM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q7N6</accession>
    <name>W6Q7N6_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="10">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PROQFM164_S02g002531</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q7N6"/>
    <dbReference type="OMA" id="LTVNQYV"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000134">
        <property type="entry name" value="MFS sugar transporter protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF64">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="67"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="158"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="186"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="280"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="322"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="346"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="376"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="416"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="446"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="28"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDM32380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="522" mass="57275" checksum="A4BFDF635F127CB7" modified="2014-04-16" version="1">MTAPVHEIETHRFDKWWKDLGMRKLLAWQATILISQMTTGYDESVVGSFQSMKPWVKDMGNPDSSRIGLITTIVFVGGFVGALIASPTADYLGRRVAMFVGASLTFSGTVIQTAAQSAGMFIGGRFLIGVGISFTCVAGPSLLFELAHPATRGTISSLFNVLWYVGSIIAAWTTFGTGYMTTSWSWRIPSLIQGIPALLVMMSVLCGLPESPRWLCAKHRPEEAQRLLAKYHSNGNMHSPLVIHEMEEIHTLLEAEAAAQKSGQSSWRILYQSPANRKRIALVATVALLTLWNGQGVIAYYFSPILTSIGITSTPQQTGINGGLQIWNLLFSLAGALLADRIGRRTLWLISFIGMILVNIPLTICSAMYAQHGSKGASFAVVVFLFFYDAAFNLANNPLLYCYPTELLPFAIRAKGLSIQVAISQAALTVNQYVNPIALESIGYYYYIFYLGMLVLGTLIIYFVFPETKGKTEVELAALFEDPKLDHTDPVMLEGLEAASDQYPKPCEKSAVVIKNEMSDSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q7Y0</accession>
    <name>W6Q7Y0_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Oligopeptide transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PROQFM164_S02g002964</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q7Y0"/>
    <dbReference type="OMA" id="ACQICLA"/>
    <dbReference type="OrthoDB" id="8904098at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006857">
        <property type="term" value="P:oligopeptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000109">
        <property type="entry name" value="POT_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018456">
        <property type="entry name" value="PTR2_symporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11654">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00854">
        <property type="entry name" value="PTR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01023">
        <property type="entry name" value="PTR2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="118"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="148"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="204"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="228"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="386"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="434"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="473"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="499"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM32813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="523" mass="57207" checksum="6BA8864E5481DBB3" modified="2014-04-16" version="1">MKNREAQSVSMSSPTLQGRIATEDEIRDLQHVPAHLPKRVWLAATIGMAERFAYYGTQTLFQNYLQNKPTDLVPGAMGLGKSTATTVNLAFTVLVNILPLPTSVLVDGVLGRYRSLQIFTCIYAVGSTVLFATSFPSEMKTGISTPGFVVGAILIALGLGGVQASIQPFIADQYTESDMRIRTNKQGQKVVEDRELTIQYIYNVYYWMVNVGSLGSVATTLMEKYIGFWSAYLLDLCAVAICVLVVQVARPKFVHPPIQGSKLPLAARCLWCAAKGGFKLDAALPEKQLEVHGRVVPWDEEFIAELRGALSAFKICIGWPIFWVCMGEGSQVSISQAGQMETHGIPNDLIKSANPVAYVLFGVIVQKQLYPFLQKRKIVFSPVNRITLGFAIMAIAMAYSAVVQNAIYQAGPCYSRPLACDASQGGQIPNHVHVLLQLPTFVIIAIAEVFCWPTGSEYTYSHAPKSMKSILQACYIGTAGLGYLLGMALSPLAKDPLLVVLWSLVAGMMFLTACAFRVAFRKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q938</accession>
    <name>W6Q938_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Mitochondrial carrier domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PROQFM164_S02g000884</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q938"/>
    <dbReference type="STRING" id="1365484.W6Q938"/>
    <dbReference type="OMA" id="IGPRTMW"/>
    <dbReference type="OrthoDB" id="276989at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000112">
        <property type="entry name" value="Mitochondrial carrier protein (Pet8), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000123">
        <property type="entry name" value="Solute carrier family 25 (Mitochondrial S-adenosylmethionine transporter), member 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45667">
        <property type="entry name" value="S-ADENOSYLMETHIONINE MITOCHONDRIAL CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="13"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="12"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="110"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="235"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDM30734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="334" mass="35740" checksum="87731D09BCEC6804" modified="2014-04-16" version="1">MAQPDGEPLVSSLWTRSLISGAIAGLTVDCSLYPLDTIKTRLQKARDHTAPQTRVSLRQTFRGIYAGLPSVLFGSAPSAASFFIVYDSVKRTLLVPQSANSKTNSQSRSHIILTHSLASSLGEIAACAVRVPTEVIKQRAQAGLFGGSSLLALKDILSLRHAVPTSTTTAPSAPAPKRGYSQVFRELYRGAGITIAREIPFTVLQFTMWESMKEAYGKRYLRTAETASSLAETQIPATTSAMFGSVAGAIAAGLTTPLDVIKTRVMLARRGVDAPVRVKEIVRGIAREGPGAFWRGITPRVTWIGIGGAVFLGSYQYASNTLEGRQAAQAEKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q9F1</accession>
    <name>W6Q9F1_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S02g003196</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM33045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q9F1"/>
    <dbReference type="OMA" id="SAFNEWP"/>
    <dbReference type="OrthoDB" id="4365116at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="18"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM33045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="103" mass="11754" checksum="D2FB8F0BBD9D67B1" modified="2014-04-16" version="1">MEQIGEDLFGSAFNEWPILLRPIWVTMILVIGGIKLFYYFLLPAAAAIIILLLAVVIVGASVGFLVRGRQLSANEDQTKRKRDDDETRPWRRVQRRLEAGELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q9J8</accession>
    <name>W6Q9J8_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="11">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">dbp7</name>
        <name evidence="15" type="ORF">PROQFM164_S02g001009</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="11">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="11"/>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q9J8"/>
    <dbReference type="STRING" id="1365484.W6Q9J8"/>
    <dbReference type="OMA" id="AVHIKAD"/>
    <dbReference type="OrthoDB" id="422663at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17949">
        <property type="entry name" value="DEADc_DDX31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025313">
        <property type="entry name" value="SPB4-like_CTE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13959">
        <property type="entry name" value="CTE_SPB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01178">
        <property type="entry name" value="DUF4217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 11 15" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="8 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="178"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="401"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="376"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="456"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="695"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="17"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="92"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="119"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="381"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="456"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="467"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="705"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="739"/>
            <end position="752"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CDM30859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="761" mass="84987" checksum="202BB40BE099E950" modified="2014-04-16" version="1">MADDGMLMNFSIGDSVIKPEAKFKGGTWRDRLTAKKRSAHRVSEKEPGDGDAAARNAASKNPNQIQLGARPVKRQRTEDSDSFNRPSAPRSGGDRRQQQHPRDPRHFVSSLFSSNPEARNPEGPKEERDAEDAKPTNAPLIDGLDTFTNLGLSPNLAAHLLTKLELKAPTAIQTSSITQLLKEESDAFIQAETGSGKTLAYLLPLVQRIMDLSKAKNEHNDTQVHRDSGLFAIILAPTRELCKQISVVLENILHCANWLVCGTVIGGEKKKSEKARLRKGLNILVATPGRLVDHLDNTEALDVSNVRWLVLDEGDRLMDMGFEEELQGIVKKLDARQRPSRVPGVPTRRTTILCSATLKMNVQKLGEISLKDAVHIKADPSEEDDEKPNEDEEESFRVPAQLKQSYAIVPAKLRLVSLTAYLKRTFMRKGSVMKAIVFMSCADVVDFHFELFSRNQDREQQRKSDGEEKDEKDEKDEEKEKLSPHGTIALGRAFSTPANPVLLHRLHGSLPQNVRTATLGSFSRSTEACVMICTDVASRGLDLPNVDLVVEYDPAFSSDDHTHRIGRTARVGRDGRALVFLQPGCEENYVEVLKRGYRDGGKALTRTDANEILKRGFGGNDNKKKNWEEKTTDWQMDVERWALDNPEYLEMARRAFQSHVRAYATHTSAERSMFDIKELHLGHLAKSFALRDRPGKINVPGLRPGQEDTKKDFKAARNGVSGNKRKADDDPSSTNVTDEAARKMRAKMREHMSGANEFNLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q9Y3</accession>
    <name>W6Q9Y3_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Taurine catabolism dioxygenase TauD/TfdA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PROQFM164_S01g000406</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TfdA dioxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q9Y3"/>
    <dbReference type="STRING" id="1365484.W6Q9Y3"/>
    <dbReference type="OMA" id="GWAPHPA"/>
    <dbReference type="OrthoDB" id="10257314at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051323">
        <property type="entry name" value="AtsK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT SULFONATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468:SF1">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT SULFONATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="8">
        <location>
            <begin position="68"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM26597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="369" mass="41469" checksum="BEC0777446277722" modified="2014-04-16" version="1">MSSTTVLTPGTITREKNENGDPLYPDYMPFYDPLEKVEDIGSFEHFDPGHRADPKFPNLLKNATKIWELSPHVGTEIHGVQLSQLDSAGLDELALLAAQRGALVFRDQDFVNIGFEAQKKIVSHFGPLHIHGWAPHPAAGSEEHMIIYDHKDDLRVRQSWAGRSPVQWHTDQSPEQQPPGTTFIAMLESPTTAGGDTLVSSSVRAYSSLSPRFRKRLEGLVAVHTNNDGVTQEMKHGQQAVMRRGVLRAEHPVVLVHPVTKQKALYVNPVYTKKIVGFDQEESDCILKFLFDHIAKRQDFSCRIRYEAGTVLVWDQRVTNHSQTLDYPVGDRRHGFRLTPLANKPIPAKVEEDDGECSKDEARVQLSLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W6QAI2</accession>
    <name>W6QAI2_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S03</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S03g000412</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QAI2"/>
    <dbReference type="STRING" id="1365484.W6QAI2"/>
    <dbReference type="OrthoDB" id="4326278at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="47"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM33688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="257" mass="29836" checksum="C560626867E6E021" modified="2014-04-16" version="1">MARKKNSMNRLLPKEPKWTESAVNPQCMINDFGISREPTPSQQDNTIKKYEEQNIQLRREMKERGNTINNLVRHHKETVSQFEYNMARMANQLQKQAKMIADLEWQKGMLLRNLEEQTRISYALGQQDTKTREVFGNISSTMFLEFDKQTGIIDEKTSAILKLEAQKQKSLAILSYKMERWLWCLNISQGTVKNVPLSGTRTEEEKMYLMIKAVLNACGESDTNGMSRTSRFLKNIRLVKCESRVTEGPRSKPTCLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W6QAW2</accession>
    <name>W6QAW2_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Genomic scaffold, ProqFM164S03</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PROQFM164_S03g000532</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QAW2"/>
    <dbReference type="STRING" id="1365484.W6QAW2"/>
    <dbReference type="OMA" id="RDCWHLG"/>
    <dbReference type="OrthoDB" id="5392646at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048401">
        <property type="entry name" value="SLS1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048748">
        <property type="entry name" value="SLS1_KH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048400">
        <property type="entry name" value="SLS1_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20777">
        <property type="entry name" value="KH_SLS1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20778">
        <property type="entry name" value="SLS1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20776">
        <property type="entry name" value="SLS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SLS1 N-terminal" evidence="2">
        <location>
            <begin position="122"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="SLS1 second KH" evidence="3">
        <location>
            <begin position="309"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="SLS1 C-terminal" evidence="4">
        <location>
            <begin position="390"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF20778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDM33808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="757" mass="84819" checksum="206589BD036456CD" modified="2014-04-16" version="1">MLRRPTGNKLGLLSFQSLSYRRPLLSYPHAVLPRYQSNWSRDDERDAFDGPKSERNREPKDNGKRETGTFTLDVDTLGKPGQIVVVPSRRRRMLNRNRNKKPGNEYAGTISTMLDELNEENSSPSDKSVHERIDEIRGSYQVGQILPAADLKALWSKLASSFTYKQLSEFISEYNRNSVIEEKGWTWGSSNSKSLLGKTKGFRGKSRAAETIVRNCWQLVADGERGQLEFRIPAQFISLLLHAEHFSFHELASLHGCGIDVTQSAGLVSLTGKRDDCESVHEIIIDATGRIREDDVGINPYIHGDGISQVFTPDFLEWVNSTHGVFVEHRAHRPPQKILYLNENKLGADNARRTLNLALSNTTSPSTPFSTYLPASELASAYSYKPETHASWFEQQKSWFRWAMSSSQNAEAESLETPFFDKHQTRLSDELLKLLRFTPPKNGFVAGLHESVTAVVGKCLFMQKPSFDDTAISPAQLGRLSLPRAFTNDVPLVSRFINTLTPIRPKNEAQLYRLRLSPTSNTASPPELEIEIAVNSNLNGVDVHSVKAILATNSVDYLLPENGLDLRFTRTISQDLLYKSSPNSENPQSSSEHLFPETSFSLPIQVMLQSIKTSLQGSIVNSGASQGPVHIPIFCNIILPCDLVHQPASQKTKSKKSDESMAESSIAVEYMFPPLSDIRGAVIQKYNFDGRPLDYRYYESGSFLAARTNEVSLGMQIPQIDLAAGNNHSEQLDHEFHSFYNAACDMAFKIHGKRYVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W6QB43</accession>
    <name>W6QB43_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Zinc finger protein ZPR1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">ZPR1</name>
        <name evidence="11" type="ORF">PROQFM164_S02g001504</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Acts as a protein folding chaperone for elongation factor 1-alpha.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ZPR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QB43"/>
    <dbReference type="STRING" id="1365484.W6QB43"/>
    <dbReference type="OMA" id="FREVVIM"/>
    <dbReference type="OrthoDB" id="308464at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.420:FF:000001">
        <property type="entry name" value="Zinc finger protein ZPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.420:FF:000002">
        <property type="entry name" value="Zinc finger protein ZPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.1040:FF:000001">
        <property type="entry name" value="Zinc finger protein ZPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1040">
        <property type="entry name" value="ZPR1, A/B domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.420">
        <property type="entry name" value="ZPR1, zinc finger domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004457">
        <property type="entry name" value="Znf_ZPR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040141">
        <property type="entry name" value="ZPR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042451">
        <property type="entry name" value="ZPR1_A/B_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056180">
        <property type="entry name" value="ZPR1_jr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042452">
        <property type="entry name" value="ZPR1_Znf1/2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00310">
        <property type="entry name" value="ZPR1_znf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10876">
        <property type="entry name" value="ZINC FINGER PROTEIN ZPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10876:SF0">
        <property type="entry name" value="ZINC FINGER PROTEIN ZPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22794">
        <property type="entry name" value="jr-ZPR1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03367">
        <property type="entry name" value="Zn_ribbon_ZPR1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00709">
        <property type="entry name" value="Zpr1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Zinc finger ZPR1-type" evidence="10">
        <location>
            <begin position="40"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="Zinc finger ZPR1-type" evidence="10">
        <location>
            <begin position="262"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="444"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="469"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="480"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00054139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDM31354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="491" mass="54418" checksum="93DE58C8EC012703" modified="2014-04-16" version="1">MVTVSKADNDALEAQFESQFQKPGDLVERDDDTGAMSIESLCMNCHEQGVTRLLLLRVPYFRDIILESFECEHCHFKNNSIKSAGQIQERGTVYTLRVENEEDLQRQVIRSDVSGFKLTTKEGKEIEVPKGTGQLTNVEGMVQLIHENLSGEQDLRKEQAPELYNALVPVIASLEKIMKREDAFPFTITLDDLTGNSWIAPNANDRGNKYKRHEYPRTHEQNEELGISADENAVNKEDTAEVGAGDPDDLDIVDGQVYSIPAECPGCNKQAEVNIKKVNIPYFKEVLLFGTNCDHCGYKSSAIKTGGEVPEKGRRITLEVKNEVDLSRDILKSDSAGLYSPELDLDVQPGTLGGRFTTVEGLLVEIRDQLKGAIFDVDDSAHSGGDSMVSSDKDKWQRFFSRLDQAINGELKFTITLQDPMASSYVQDLCSPAADPQITIEDYTRSAEEEDDLGLTHMKTEGYEEAEAEAAKAKADAAKADATTTDATQKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W6QC75</accession>
    <name>W6QC75_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S02g001905</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QC75"/>
    <dbReference type="STRING" id="1365484.W6QC75"/>
    <dbReference type="OMA" id="DSDWDRS"/>
    <dbReference type="OrthoDB" id="5428925at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="79"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="187"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="334"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="486"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="427"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="8"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="192"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="220"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="265"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="509"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM31754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="538" mass="59431" checksum="5A404FD8B4BB64F7" modified="2014-04-16" version="1">MSRYPTRSIASAGSESIRSIQRTPPARGDCSANPTSYKADDDTALPSMEFHSHHSQPSIAHRRTGSTLKTVMRKIFNRKRQSQADELEEHPYESTFAVPPMPPVRRGGQPKGKSPSAVPPPLNLNSHRSPLSAENLQIADNHLSPLSPLSSATLRDSVPGSMPRRRRATLPSVVFSDDDSRFAVASAVSDPQEDRGYMPERRHSLLSHRLSRSADGLREMTNNLPETLSSWKPTPSAPARPASVVSQSPPLDESSNSEQSRRRSSGTTVTSVTRMSAAPSLEVEQPTEQPSLPSNVANLVNTMHQDDGVTLEQRLTTLEVKLIDLEFAIARMQTNGPEPTEKLSRPRHPPSAESYPPRSKPTAFLSTSDRDDSPSPLPTIPARPSSTSTIRADTMNTRTLRPVPSATSLSDYHGVSIEQYSTLVTLLRREQTARRNLETQVGGLRNDIRDLQRAALESMQSGMGMGMMQPANMESRQFLRFRRALDDSNSSPPLRSDDKHTGIADSDSDWDRSDIYSRDDPFGPPKWERQRVVTAPMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W6QCQ7</accession>
    <name>W6QCQ7_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PROQFM164_S01g001188</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the paxB family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QCQ7"/>
    <dbReference type="STRING" id="1365484.W6QCQ7"/>
    <dbReference type="OMA" id="CNDIGWE"/>
    <dbReference type="OrthoDB" id="5294024at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039020">
        <property type="entry name" value="PaxB-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42038">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42038:SF2">
        <property type="entry name" value="TERPENE CYCLASE AUSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25129">
        <property type="entry name" value="Pyr4-TMTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="112"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="209"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM27377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="245" mass="27850" checksum="8FBEB5A84243160D" modified="2014-04-16" version="1">MEESSLLSAILDHRDALASVAEFLRILAGICWTLNYFSMLRTSRKDKIPSTGIFPLCNDIGWEFIYAFIYPTASAHWEGGVRVWFLVHCIVIIFIIKYAHNEWDHFPLIQRNLYFLYGVVTIGFAIGQYSFAREVGPDLGFFYGGVLCQTLASLGPIAQILSRNSTRGASLLTWLLRAIATFGGFIKLTIYYLTGNAAGPWFESPMCKFYIGLTLVLDFTYPICYYVIQRQELANAQKEKKEKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W6QCV7</accession>
    <name>W6QCV7_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring)</fullName>
            <ecNumber evidence="2">1.2.4.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">bkdB</name>
        <name evidence="6" type="ORF">PROQFM164_S03g001257</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[protein] + 3-methyl-2-oxobutanoate + H(+) = N(6)-[(R)-S(8)-2-methylpropanoyldihydrolipoyl]-L-lysyl-[protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:13457"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10497"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83142"/>
            <dbReference type="EC" id="1.2.4.4"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:13458"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="1.2.4.4" evidence="2"/>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QCV7"/>
    <dbReference type="STRING" id="1365484.W6QCV7"/>
    <dbReference type="OMA" id="SRMRHHC"/>
    <dbReference type="OrthoDB" id="878at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003863">
        <property type="term" value="F:branched-chain 2-oxo acid dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009083">
        <property type="term" value="P:branched-chain amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006091">
        <property type="term" value="P:generation of precursor metabolites and energy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007584">
        <property type="term" value="P:response to nutrient"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07036">
        <property type="entry name" value="TPP_PYR_E1-PDHc-beta_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.920:FF:000001">
        <property type="entry name" value="Pyruvate dehydrogenase E1 beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000001">
        <property type="entry name" value="Pyruvate dehydrogenase E1 beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42980:SF1">
        <property type="entry name" value="2-OXOISOVALERATE DEHYDROGENASE SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42980">
        <property type="entry name" value="2-OXOISOVALERATE DEHYDROGENASE SUBUNIT BETA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="TK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transketolase-like pyrimidine-binding" evidence="5">
        <location>
            <begin position="63"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00051764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDM34533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="387" mass="42403" checksum="AD160FBF7B0DF462" modified="2014-04-16" version="1">MASLRTPLRFFAQAPRRFYSGAPTPAAKLNLPIDYKTTPILHHTSASLSNTSEYPAAATSKRLNLYQAINSALRTALSKSDRTIVFGEDVGFGGVFRCSMDLQTEFGSDRVFNTPLTEQGIAGFAIGAAAEGMKPIAEIQFADYVFPAFDQIVNEAAKFRYREGGTGINVGGLVIRMPCGAVGHGALYHTQSPESLFAHIPGLRVVMPRSPAQAKGLLLSSIFEHNDPVIFLEPKILYRAAVEYVPNEYYTIPLSKAEVIKPGKDLTVISYGQPLYLCSSAISAIEKAMPGVNVELIDLRTIYPWDRQTVIESVKKTGRAIVVHESMINYGVGAEVASTIQESAFLRLEAPVKRVAGWSTHTGLSYEQFILPDVTRIYDAIKQTLEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W6QE83</accession>
    <name>W6QE83_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S03</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S03g001060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QE83"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM34336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="51" mass="5544" checksum="555092CCE485F742" modified="2014-04-16" version="1">MRSETVKPSTLKLRKDIGLVVFHLSTAGTGTAALSGFFIDRSDMVINFSID</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W6QEB7</accession>
    <name>W6QEB7_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein kinase-like domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S01g001743</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. ADCK protein kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QEB7"/>
    <dbReference type="STRING" id="1365484.W6QEB7"/>
    <dbReference type="OMA" id="KVQYPWI"/>
    <dbReference type="OrthoDB" id="427480at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13969">
        <property type="entry name" value="ADCK1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004147">
        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045307">
        <property type="entry name" value="ADCK1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051130">
        <property type="entry name" value="Mito_struct-func_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43173:SF19">
        <property type="entry name" value="AARF DOMAIN-CONTAINING PROTEIN KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43173">
        <property type="entry name" value="ABC1 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03109">
        <property type="entry name" value="ABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ABC1 atypical kinase-like" evidence="2">
        <location>
            <begin position="211"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM27932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="619" mass="69469" checksum="C48A132159CF2DE2" modified="2014-04-16" version="1">MSAALRVSLRTFKIDPATVTSKPSTSGSSFLLASNSLLRHSPSFGRINTSSWTRSVSSHGSTLASSSRSFSVKASPLLSAEAKSQHKSENEPNMNASQRSMIKWFIIGSILGLGTVTFSDQAQHALGAAKRSGRVVGALAVCINDYRVTLKQAALSPEEHNALIHACHKRCAERTLHVLEKNGSIFIKLGQHLSSMGYLLPIEWTSTFIPLQDRCPVSSIESIDELFRKDTGQSMNELFASFEEKPIGAASLAQVHIATLKETGQKVAVKVQHPALDEWVPLDLALTRFTFSMLKRFFPDYDLEWLSKEMDFSLPQELDFRMEAQNATHASEYFKKHTDAPLVIPEVMWSQRRILVMEYIAGHRPDDLAYLDANHIDRDEVSAALAHIFNEMIFGDNAPLHCDPHGGNIAIRPNHTRSHPNFDVVLYDHGLYRNIDRDLRRNYAKLWLAVIDGDVPRMREFAYKVAGVTDKQFPLFASAITGRDYSVITKESVVSPRTAKEKDDISGALGEGMLQQLVVLLGQVPRIILLILKTNDLTRSLDENLHTRQGPMRSFLILARYATRTVFEEQLDLINESGGVFRNFFRFLWAYASYLRVEVKLSVYETVLSLKSRFGLRSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W6QEQ3</accession>
    <name>W6QEQ3_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S02g002835</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QEQ3"/>
    <dbReference type="OMA" id="KMAIVEY"/>
    <dbReference type="OrthoDB" id="4239453at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM32684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="193" mass="21849" checksum="CAEE13CB88C7E026" modified="2014-04-16" version="1">MSRMLEKEWDLAISLIHPLNVYKLSARVIRLAIESEHIESADFAFEVGILFGEASTEEVTYLLEHPSKDETNENQQVATRRRTKLFSSYHSFAGHLRDIPNTSTAVPVRLVPSAGPSNKGMLHHYWSVETGVLPECDSSVAISRGKMAIVEYPSSRALVVEMPQMVAPETKPRFLLWLFPHDLEVSWSAMEPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W6QFJ3</accession>
    <name>W6QFJ3_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">F-box domain, cyclin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S01g002173</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QFJ3"/>
    <dbReference type="OMA" id="LLTTHEH"/>
    <dbReference type="OrthoDB" id="8864979at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="49"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM28362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="411" mass="47412" checksum="C1697A4714349E35" modified="2014-04-16" version="1">MSGFAKFALSVQKVRAAIHNRRKVGAKDHRGSTLRKDPADPPLPSPWDLPVEIQIRIFAYSGITDFHPLRLVCKAFCQLLTSNEHEIVRQYLRLRRHGTLPSPIDNDRIYTRNPGDDVVLLSDLFPPSKSARGGHLYTFKYLHGLRRRQMLCSRLCYYLADRILDRFIQTEPAVMKASFPAKRNERNALVKRGIASIWFHLAPLMYYTLYFFESYASARREHTNMLVQKYEAGQLPVPLPLEVRQRMYRELQTRILQSPPFTNTAALVATHHCMHLLVSYIRYAMSLDGHDIDDSWISSLLTLAPFVRIVEFFSAEIGDGGSQRAQRKEFMYNFYQDTTMYEKDPMDSVVFARVSAQNLHSSVQDIWFAAAEAELKARKAIPHNVEHVWIWNGIPIVFGCPDCHPTRGWQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W6QFK0</accession>
    <name>W6QFK0_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Probable transposable element</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S04g000469</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QFK0"/>
    <dbReference type="OMA" id="RKMICHE"/>
    <dbReference type="OrthoDB" id="2499658at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase zinc-binding" evidence="2">
        <location>
            <begin position="238"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="286"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM35588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="413" mass="46625" checksum="9E8EF2FEAC663C30" modified="2014-04-16" version="1">MSSFTRRNEGNDAYLMNHQMAMPGSYGQPESHDFKQESHDFNTHGSGSYHFPQHSFNPYGSQFGQPYGPQSSLSPGLQHLQYTSEHSIPSMTTPDDPRLHHPPQFMSQSRYLQGPRYLPRDPLGETEIESQESHNEVTLLSEAVVPALSGFPDVKEFDQLMQNYVEDLSIKKQDKALIYARRARNIRTVLIDPKDTAVESAQFRFWVKKMFKLQAVGSDHRKMICHEGKPVAIREKLFKILTKAHQQCQHGGRDKTSAQVRRIYSWVPKELISRFVKICPTCQVRRGGSRLTPPNSRRSSPRLEMVSRSPKLPSPPISRRESTFAGQLPLDRTQADYFGHLHGHGGWLDSHQNVQSRSNLGNGVRSFQGSMGNLSHSIAGTLDSFSADLSIPPSQLSYTTGYVPHGAAPQREY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W6QFV8</accession>
    <name>W6QFV8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S03</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S03g001573</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QFV8"/>
    <dbReference type="STRING" id="1365484.W6QFV8"/>
    <dbReference type="OrthoDB" id="4312532at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM34846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="205" mass="23182" checksum="C9AAE6CD6DBEDC31" modified="2014-04-16" version="1">MSDSEAQATGAPGTKTNPGARNKRDWDEACLENPADEDQPTHLPELGTFGIFCPLAPLKDRGGFDEWFTAVEQCLRPTSLSEFNGPEEFINTLAYRYKVNRELKGNIPPYTALIMMFQELQYLPRFDTIINIWNGELCLLKDPATTITYGDFLAYSSAMQTEARCQANTSFCLTWRLAHPQPTNLFDVLAENPYLHTCLNYVLQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W6QG29</accession>
    <name>W6QG29_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type DNA-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PROQFM164_S04g000624</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QG29"/>
    <dbReference type="STRING" id="1365484.W6QG29"/>
    <dbReference type="OMA" id="WAIRALN"/>
    <dbReference type="OrthoDB" id="3525185at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053178">
        <property type="entry name" value="Osmoadaptation_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38111:SF6">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G01940)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38111">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="9"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDM35743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="454" mass="50898" checksum="222DEF7B179EA927" modified="2014-04-16" version="1">MPGVPHSKGCLQCISRKVKCDKTRPECLRCINWGSECPGYDRGHKFKDQTRYITLKHGRPTMDEAFAPNLAYEAINVQTQESFEVWLDYHFPSYLASFNSRVEMNWMKFIRGRWSTFPQALIWALRALTCLRMGAARGNKEAIMCARHMYGRGVNHLASLLHTRAALADETLAAAILLGGYEVLDGSSDRSWIIHSHGIRHLFCARGPSAHTHGMGRTLLISWRPYLVADAFIHAEPCFLGGSEWTCVSAIQEIARAEDRWQESSLLGQTMDYAFNEVAKCPGYYAMTKYFTTSDTDVDRSILNGLVSCILKSRESLVQFHGMLMETDPPASFVGVIPSTYATTLVQGTRDGINSAVALLDQLMTLLKSHLNRKTNPILMADFDDKHQEDPWRLFAGVQALKTNTNQSLLSRDQKDPSLSIYAVRDQLDKFSLTMGMGSLLPDACGCPQFLAHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W6QG32</accession>
    <name>W6QG32_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate reductase</fullName>
            <ecNumber evidence="4">1.1.1.302</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">2,5-diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">RIB7</name>
        <name evidence="15" type="ORF">PROQFM164_S02g003306</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes an early step in riboflavin biosynthesis, the NADPH-dependent reduction of the ribose side chain of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, yielding 2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>2,5-diamino-6-(1-D-ribitylamino)pyrimidin-4(3H)-one 5'-phosphate + NAD(+) = 2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27274"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58890"/>
            <dbReference type="ChEBI" id="CHEBI:59545"/>
            <dbReference type="EC" id="1.1.1.302"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>2,5-diamino-6-(1-D-ribitylamino)pyrimidin-4(3H)-one 5'-phosphate + NADP(+) = 2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27278"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58890"/>
            <dbReference type="ChEBI" id="CHEBI:59545"/>
            <dbReference type="EC" id="1.1.1.302"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; riboflavin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HTP reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.302" evidence="4"/>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM33154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QG32"/>
    <dbReference type="STRING" id="1365484.W6QG32"/>
    <dbReference type="OMA" id="HYLRYHH"/>
    <dbReference type="OrthoDB" id="5432at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008703">
        <property type="term" value="F:5-amino-6-(5-phosphoribosylamino)uracil reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="entry name" value="Dihydrofolate Reductase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002734">
        <property type="entry name" value="RibDG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050765">
        <property type="entry name" value="Riboflavin_Biosynth_HTPR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38011:SF7">
        <property type="entry name" value="2,5-DIAMINO-6-RIBOSYLAMINO-4(3H)-PYRIMIDINONE 5'-PHOSPHATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38011">
        <property type="entry name" value="DIHYDROFOLATE REDUCTASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_8G06820)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01872">
        <property type="entry name" value="RibD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="Dihydrofolate reductase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0686">Riboflavin biosynthesis</keyword>
    <feature type="domain" description="Bacterial bifunctional deaminase-reductase C-terminal" evidence="14">
        <location>
            <begin position="36"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CDM33154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="279" mass="30208" checksum="9FFAF286A157BFBF" modified="2014-04-16" version="1">MTSAPRDALEFPDSDRGFLEPHLPPRDGSAPESDLPFTTLTFATSLDASLALSPGARTVLSGPQSKAMTHYLRSRHDGIIIGVGTAVADDPGLNCRITGVGGYGKPGLDGQPRPVVIDPTARWDFSDDSKLFQLCREGRGLAPWIITAVEKPNAKKQALLEKYGGRFIPVKMLRTHTGRHQVDWPDLLVTLKSNGLNSVMVEGGGQVIKSLLCPLYMSLLDSVIVTIAPTWLGEGGVVVSPDRRFDEDGNAISAARLKNVKWYPFGEDVVLCGQIKLYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W6QG89</accession>
    <name>W6QG89_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BTB/POZ fold</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S03g001713</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QG89"/>
    <dbReference type="STRING" id="1365484.W6QG89"/>
    <dbReference type="OMA" id="HYDINQP"/>
    <dbReference type="OrthoDB" id="6359816at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843:SF5">
        <property type="entry name" value="BTB_POZ DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="28"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM34986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="252" mass="29062" checksum="0D8FB768ADA1E0C4" modified="2014-04-16" version="1">MELTSNSVEGTDRFVHRLGNFHRTGIFSDLTIYTADQVLSVHRIVVCSRSEAFCRHFADLSSESDEDAHVFEIKDEHPRVVEAMIRSFYGLHYDINEPEHQMCPLLFNVKVYSIADKFEVEYLKVQAKLTFVTLAQDHWDSVEFLVAAFQAYKTTPKLDRGLRDVVVAVCQIHRRELREKKGFEKLLEEAPGLATDLVLLSQRWLPQSASTRVRIVQSFSCLSCFAKWQIQVDMAEYFTACPFCQDERVTAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2024-10-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>W6QGQ9</accession>
    <name>W6QGQ9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S01g002593</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QGQ9"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM28782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="33" mass="3886" checksum="7161494157DBB865" modified="2014-04-16" version="1">MKVEEDEGLSTQFAFEKVIWNIPCQDLVWGEPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W6QGU1</accession>
    <name>W6QGU1_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S04</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S04g000536</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
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    </dbReference>
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    <dbReference type="Proteomes" id="UP000030686">
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM35655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="112" mass="12668" checksum="EFFB8199A1D32063" modified="2014-04-16" version="1">MTVVSSSRYSTGEIATAEAAESFSWEAPVPVNRFWDSFSYGTARSFLGNFSDAELEQLAIDPVVIDSDNTADQQKKLQLLLQLLRNKLANEETAHSRPQSLYDVDYKRWYGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W6QGW5</accession>
    <name>W6QGW5_PENRF</name>
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        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S04</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
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                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35680.1"/>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QGW5"/>
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    <dbReference type="OMA" id="PGENRWR"/>
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    <dbReference type="Proteomes" id="UP000030686">
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM35680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="127" mass="13671" checksum="B5F6CF0129AC7EEA" modified="2014-04-16" version="1">MSGSSDTRWRGGPSRQGSQRNSNNRDKTGGQGSARDNNATWGASNPPQEQHVPVRGFNTAEVKNVLKAGPHETKSAVPYKSHSKDGPTQRSTAWGAKAQNMANGRDFFLELRKQITSLQRSGPPVGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W6QHB6</accession>
    <name>W6QHB6_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S04</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S04g000686</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QHB6"/>
    <dbReference type="Proteomes" id="UP000030686">
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    </dbReference>
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        <location>
            <begin position="15"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM35805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="66" mass="7413" checksum="BD74DD63453470F1" modified="2014-04-16" version="1">MVNIFLTLYSSTGILPREAGGLNPVTKAPTAPRSKNRRKPGRRPGRRETAFGRSYIHFTVRRRTGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W6QHS9</accession>
    <name>W6QHS9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g002974</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QHS9"/>
    <dbReference type="OrthoDB" id="10357146at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM29162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="177" mass="19486" checksum="F88980EBE34B660D" modified="2014-04-16" version="1">MPQRGRESSVSHKRPLVPPSTIPLASHWKQHSTQPSSGHVTLPSEEDSEGILTSDCAKVNHVFGGVKDGLSETRRGLVPEEEDSDGRQGEDIEQSPTGVMTKFYEMGGGGYRKGGAEDTGQGSKEDTILRAYYMHGFSESLGGHRRHQNPNLWNFSIRDSTLVTCSMKRTLRAFLKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W6QHY5</accession>
    <name>W6QHY5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S04</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S04g000921</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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        </lineage>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
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    <dbReference type="Proteomes" id="UP000030686">
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM36040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="149" mass="16538" checksum="E692751FEE229EA7" modified="2014-04-16" version="1">MADGGNWRFRGEGHTSKRGGGSEPNPTTDDSSTRKRYIDWKKILRTNSIGVRSRGGQEEILRLWEGVVEILDSGNTGDQQLLVKYLVDDALDGHGFFLETIDTTGQDWSRRIPVYVEPFLKAITHPSLLDCLSVDSFVGTMYATFGGPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W6QJJ1</accession>
    <name>W6QJJ1_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S05g000811</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792019">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QJJ1"/>
    <dbReference type="STRING" id="1365484.W6QJJ1"/>
    <dbReference type="OMA" id="FWINEES"/>
    <dbReference type="OrthoDB" id="4271839at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM36978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="257" mass="28989" checksum="930D591B64B24F1D" modified="2014-04-16" version="1">MLPKTPAETLASLGFDPQLLEYPFPAETGWCIHCFRVSLRAWDETKWGQPFKVNCIRDPVTSKRCQRCCHARHRCELPYEGIRGHGFELQALLEWVQEIWINEESGIGKGEDVGLVHDIEIVNAVAGAVRDLCSALDCLIKSHGKAHSLAGRHGGDAADMAAYTQYCTHQHASFQAPSSLGLRSDGTPHPKLVQFEHAARQYLRLETQFALPWYIEVLALKQTIEALIREKYDHSDPNIARWYKDMMAAFPLAIPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W6QJM4</accession>
    <name>W6QJM4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
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                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
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            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">FM164</strain>
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</entry>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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                <person name="Dupont J."/>
                <person name="Gouzy J."/>
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                <person name="Abraham A.L."/>
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                <person name="Renault P."/>
                <person name="Dupont J."/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ANTHRANILATE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02885">
        <property type="entry name" value="Glycos_trans_3N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00591">
        <property type="entry name" value="Glycos_transf_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52418">
        <property type="entry name" value="Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyl transferase family 3 N-terminal" evidence="4">
        <location>
            <begin position="42"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 3" evidence="3">
        <location>
            <begin position="120"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 3" evidence="3">
        <location>
            <begin position="319"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDM36825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="441" mass="47236" checksum="8638DA11537DA29B" modified="2014-04-16" version="1">MATSTSSPSQRPESISIAPLLQRLAYPAAAGIRVSAQDLPAVSAEEIASAFALIFEDRLSQIQTAALLTLLHSTGKDRQADVIAKCSQCMREAACQVEKGPLTKIIKSRNLKAGNYQGGLCDIVGTGGDSHSTFNISTTSSIVASPLLMTAKHGNRAQTSTSGAADVLNAIQPLAPKIAAITADNLAQVYEKTNYSFLFAPNFHPGMMHSNPVRRALGLRTIFNLMGPLANPVDWALEARVVGVAYQSLGPVFAEAFKQSGAKKAMIVCGAEDMDEISCAGKTNCWRLSEYPNPAYKASEDDADDSSDDDTDNPRTLVKIDTFQLQPSDFGLSTHPLSDVGGGKMPKQNAEKLMSILRNELPRDDPILEFVLMNVAGLLVTSGICEADTSNMGPGDDGQVITERGPAGGRWKEGVRRARWAIESGQSLKHLEQFIEVTNQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W6QL84</accession>
    <name>W6QL84_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pheromone</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S03g001686</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QL84"/>
    <dbReference type="STRING" id="1365484.W6QL84"/>
    <dbReference type="OMA" id="QGCYMLK"/>
    <dbReference type="OrthoDB" id="3641074at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004880314" evidence="1">
        <location>
            <begin position="19"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM34959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="123" mass="13164" checksum="6D7FA5E2CF4A13EC" modified="2014-04-16" version="1">MKFTSVVIAVLAAGTVQAAATPQTTLPKWCGHIGQGCKRTTDASVDVKRSADALAEAMAKNLPLVLQKWCGHIGQGCYKAKRAADAVDEVKRTADALAYAMAALEEEEEDVSYTMNSVVLQHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W6QL93</accession>
    <name>W6QL93_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Decapping nuclease</fullName>
            <ecNumber evidence="7">3.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">rai1</name>
        <name evidence="9" type="ORF">PROQFM164_S06g000580</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Decapping enzyme for NAD-capped RNAs: specifically hydrolyzes the nicotinamide adenine dinucleotide (NAD) cap from a subset of RNAs by removing the entire NAD moiety from the 5'-end of an NAD-capped RNA. The NAD-cap is present at the 5'-end of some RNAs and snoRNAs. In contrast to the canonical 5'-end N7 methylguanosine (m7G) cap, the NAD cap promotes mRNA decay. Also acts as a non-canonical decapping enzyme that removes the entire cap structure of m7G capped or incompletely capped RNAs. Has decapping activity toward incomplete 5'-end m7G cap mRNAs such as unmethylated 5'-end-capped RNA (cap0), while it has no activity toward 2'-O-ribose methylated m7G cap (cap1). Also possesses RNA 5'-pyrophosphohydrolase activity by hydrolyzing the 5'-end triphosphate to release pyrophosphates. Stimulates exoribonuclease activity of Rat1, allowing it to degrade RNAs with stable secondary structure more effectively.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside-ribonucleotide in mRNA + H2O = a (N(7)-methyl 5'-triphosphoguanosine)-nucleoside + a 5'-end phospho-ribonucleoside in mRNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66928"/>
            <dbReference type="Rhea" id="RHEA-COMP:15692"/>
            <dbReference type="Rhea" id="RHEA-COMP:17313"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:138282"/>
            <dbReference type="ChEBI" id="CHEBI:172876"/>
            <dbReference type="ChEBI" id="CHEBI:172877"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="3">
            <dbReference type="Rhea" id="RHEA:66929"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 5'-end NAD(+)-phospho-ribonucleoside in mRNA + H2O = a 5'-end phospho-ribonucleoside in mRNA + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:60880"/>
            <dbReference type="Rhea" id="RHEA-COMP:15692"/>
            <dbReference type="Rhea" id="RHEA-COMP:15698"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:138282"/>
            <dbReference type="ChEBI" id="CHEBI:144029"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:60881"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 5'-end triphospho-ribonucleoside in mRNA + H2O = a 5'-end phospho-ribonucleoside in mRNA + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78683"/>
            <dbReference type="Rhea" id="RHEA-COMP:15692"/>
            <dbReference type="Rhea" id="RHEA-COMP:17164"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:138282"/>
            <dbReference type="ChEBI" id="CHEBI:167618"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:78684"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the DXO/Dom3Z family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.-" evidence="7"/>
    <dbReference type="EMBL" id="HG792020">
        <property type="protein sequence ID" value="CDM37618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QL93"/>
    <dbReference type="STRING" id="1365484.W6QL93"/>
    <dbReference type="OMA" id="VVTWRGH"/>
    <dbReference type="OrthoDB" id="5853397at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034353">
        <property type="term" value="F:mRNA 5'-diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110155">
        <property type="term" value="P:NAD-cap decapping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013961">
        <property type="entry name" value="RAI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039039">
        <property type="entry name" value="RAI1-like_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12395:SF9">
        <property type="entry name" value="DECAPPING AND EXORIBONUCLEASE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12395">
        <property type="entry name" value="DOM-3 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08652">
        <property type="entry name" value="RAI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RAI1-like" evidence="8">
        <location>
            <begin position="22"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00044676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00046211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM37618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="373" mass="42879" checksum="198EFF4A01236950" modified="2014-04-16" version="1">MNRSTFNIQPLHRFHSANTSIRRPREIACFSYDENRRFSLGDSSMAYYYTPALPADLNIGYETFQKLNDVPDEHLDALLDTLVAHEKETEKKCDVDIVTWRGMMTKILTAPFDNMNGFEMNATCFQGTIFIEENNEYKNQQKEIQRKRGSPPGMAPQELMMYWGYKFEKLAVLPKTWDESTREEIEGRQNEVVNNAAQYCSVVRTGIGNVRMILGGEVDAIWDSKPSRKESPINWVELKTSAQICNERDMIKYERKLLKFWAQSFLLGVPKIIVGFRDENGICHSLEELDTASIPGKVLSVGRRSWDGNVCINFTGAFLEWLKQTINQEGTWRIRKKEKSPVIEVYQVEEQGHGDIISPAFKAWRSTTTNASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W6QLP4</accession>
    <name>W6QLP4_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DUF1446 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S06g000316</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792020">
        <property type="protein sequence ID" value="CDM37355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QLP4"/>
    <dbReference type="STRING" id="1365484.W6QLP4"/>
    <dbReference type="OMA" id="HAMSRMV"/>
    <dbReference type="OrthoDB" id="10265871at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056362">
        <property type="entry name" value="AtuA-like_ferredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010839">
        <property type="entry name" value="AtuA_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47585">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47585:SF1">
        <property type="entry name" value="DUF1446 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07287">
        <property type="entry name" value="AtuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23544">
        <property type="entry name" value="AtuA_ferredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyclic terpene utilisation N-terminal" evidence="2">
        <location>
            <begin position="7"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="AtuA-like ferredoxin-fold" evidence="3">
        <location>
            <begin position="493"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM37355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="609" mass="66897" checksum="558E042D8818B347" modified="2014-04-16" version="1">MPPKRDIRIGNVSGATGDSPHAMRRMAQDGNVDVIVGDWLSEMNIAWNAIAKDQDPSLGYEAGFLTQLSESIDLIVEKGIKVITNAGALNTQALAAQVQEMCRARGHKDVVIAMVLGDDISQTVTDPAKCQNLLHLDHPDWALKDWQLEPYCGVAYIGGWGIVEGIKAGADIIICGRVTDASPVIGAAAWWHNWARDDWDRLAGGLVAGHLIECGPYVTGANFSGFKSILPELVDLAFPIAEITSEGSCTITKPEAHAGAVTKHNTIAQFLYELQGEQYLNPDVVANLHNVTMEQVAPNRVHVHGITGSPPPATTKAMIAAKGGYQAEATFYINGLDVSEKVEMMRNQLLHIFRDHKFSKFSIELYGTPASNPSSQQAGTVFLRVFAQAKKKEDICAEKFKIPIYALRMQSYPGYHMNLDFRTMDPKPFMEIFPVIISMASLDHQTHVLGSTVSSPILIEPPKITSKYPDIRDSYETANAVDLASFGPTQLAPLGHIVHARSGDKADNSNIGFFVRNQDEYPWLQSFLTVSRIKSLFGDDWTKGENHADRRVERCEFPNIFAVHFRVLDFLDGGIASSSRIDGLGKGIGEYLRSKVVPIPVQFLERGCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W6QMR6</accession>
    <name>W6QMR6_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycoside hydrolase, family 71</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PROQFM164_S09g000094</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792023">
        <property type="protein sequence ID" value="CDM38178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QMR6"/>
    <dbReference type="STRING" id="1365484.W6QMR6"/>
    <dbReference type="OMA" id="CAFNCNL"/>
    <dbReference type="OrthoDB" id="1046782at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051118">
        <property type="term" value="F:glucan endo-1,3-alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:RNA nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11577">
        <property type="entry name" value="GH71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.30">
        <property type="entry name" value="Microbial ribonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005197">
        <property type="entry name" value="Glyco_hydro_71"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051130">
        <property type="entry name" value="Mito_struct-func_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016191">
        <property type="entry name" value="Ribonuclease/ribotoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43173">
        <property type="entry name" value="ABC1 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43173:SF33">
        <property type="entry name" value="ASCUS WALL ENDO-1,3-ALPHA-GLUCANASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03659">
        <property type="entry name" value="Glyco_hydro_71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53933">
        <property type="entry name" value="Microbial ribonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004882177" evidence="4">
        <location>
            <begin position="20"/>
            <end position="1237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="836"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="843"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="854"/>
            <end position="865"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDM38178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="1237" mass="131574" checksum="34A17717B79160AC" modified="2014-04-16" version="1">MRLSSLLAVALLGHCQVQAAAVFAHFMLMNAENYTVTDWQTDIQAALDAHINAFALNMAVDSRVAEILPTAFQAAHDKHFSLFFSFDYAGNGPWKAGDVAALLEQYTASTAYYLYKGQYIVSTFEGPAHAEDWIDLKQQYNVFFVPDWSSIGAKPASQLGGGVADALFSWAGWPWGPQDMDTYTDASYYQYLNESGSKPYMMAVSPWFFTNLPGYDKNWLWRGDDLWYDRWVEVLYNQPEFVEIISWNDYGESHYIGPLYDYAMEAFTIGKAPSNFAKDMPHDGWRLNLPFLIDLYTEGTATVTEENVVTWYRLSPGTACDSGTTGNTANQLQMEFAPSQIVQDRVFYSALLVEPATVTVSIGGVVQEGSWTWAPDGKIGIYHGSVPFTGTGEVIVTISRDGTQLAQVTGKAISSACTDGLFNAWVGSATSPAAVSAKPPLSISEQACINGTGAYNFAGLCDFACSYGYCPVTACTCRQMGKPLAAPNSTGVIGYPIAGEDASYSGLCAFNCNLGYCPSSACGTEQVPLVIPTVSDFAPPACIAGTGSGTLTGLCSFACNYGFCPMHVCTCTAQGGLVPAPPTTGTGATPIDGLEDHGLCNFACSHGYCPEGACVEAGSKSSGEVYVPPGIWDNTDPEVQCIPPCKIILPPFPLGSTTTIQFPSMVSSVWTRSGTSTGTKTTILNVPSLVTDKVPFWPVVIGADTSPTGFYPLQSFMPESSELVLSGDEAPFSPVPSGSATPAPVFPGAPYTVTYQPQATKSISLSVNIPSVTWSSASPTESCTSGCGTDSCKLFGGCDSTDPIDDCGLYGCGGGCSIQSCDQSCGVACSTDQHHLDSDSTGSSGGGGGGGSDSGSSSSGGSADGQQANLPMDYDGPDGLANGEWNPTPILVEDAAAVTSGMSAIMAQGTPCFESALSLLTASQTVPADLYSTVHASATSLKQSMSTQISDLKDKINAADPENFQAVTSWFTTWQDDFNVRVDSMIQGIEEPYAEIELQVSLGRAQDDVDIFSEAASIEANEDICEINPNMGSSTHPITRKRAIPPSCAPDFQGDPGEPSNAAKIPEWIGCDTRLGFEYASSADILGAMKQGIKYFLSNARGVPRSGQPDWQTAAKAAYPHIYSNSDNIDFSDECMNAGGDYTGFIEFPIMPDGSILEAGRNSRIDVGVQRVVFKAKASRDRAATDWSYLYCGVMSHFTNLLETHIIDGEPKRVLPFKLCEATCASDVVGQCSWMWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>W6QMT1</accession>
    <name>W6QMT1_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Homeodomain-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PROQFM164_S04g000360</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QMT1"/>
    <dbReference type="STRING" id="1365484.W6QMT1"/>
    <dbReference type="OMA" id="KMAISYA"/>
    <dbReference type="OrthoDB" id="10056939at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008422">
        <property type="entry name" value="KN_HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050224">
        <property type="entry name" value="TALE_homeobox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11850">
        <property type="entry name" value="HOMEOBOX PROTEIN TRANSCRIPTION FACTORS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05920">
        <property type="entry name" value="Homeobox_KN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 4 7" id="KW-0371">Homeobox</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="6">
        <location>
            <begin position="221"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="4">
        <location>
            <begin position="223"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="285"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="13"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="56"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="74"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="288"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="306"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM35479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="315" mass="35775" checksum="E0444C7BA9498702" modified="2014-04-16" version="1">MSQSHEVDEHTNMAISYTTQSSTGHPHQTLPSFRELLPAHLHDEIESTSPFYTPRHSQDRPPSSHEMADPRSISYGNQPNQIPYESHREYTVSRGPDHQPRMPDPGHHHMHLSENASRGPSPILPPIRDLDSMPGRAMNPSASSGYSERPPRSDPFIAQEYRQPAPTAAMSDPRGEHFTQPIMHPQSPYGHPAIGYDEQISPQMMGHGQGNFGIMGDPIDPKTKRRRGNLPKPVTDILRAWFHEHLDHPYPSEEDKQMFMTRTGLSISQISNWFINARRRQLPALRNQMRSGADTESQRQSPFSDVDEHIPSPRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W6QN45</accession>
    <name>W6QN45_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S07g000148</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792021">
        <property type="protein sequence ID" value="CDM37800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QN45"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM37800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="62" mass="6762" checksum="5F9B14122ED0DFD3" modified="2014-04-16" version="1">MAVGSLLGEKHSFHSSGCSPQCDSAVVGISEIGPLRLWHVIDRDRISQLPVDQDIYVESDPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W6QN52</accession>
    <name>W6QN52_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Sugar phosphate transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PROQFM164_S04g000465</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the import of GDP-mannose from the cytoplasm into the Golgi lumen.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homooligomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TPT transporter family. SLC35D subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QN52"/>
    <dbReference type="STRING" id="1365484.W6QN52"/>
    <dbReference type="OMA" id="IWFRSPT"/>
    <dbReference type="OrthoDB" id="1588579at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004853">
        <property type="entry name" value="Sugar_P_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03151">
        <property type="entry name" value="TPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="204"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="260"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="284"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="331"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="391"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="418"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="Sugar phosphate transporter" evidence="11">
        <location>
            <begin position="130"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="509"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="23"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="538"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDM35584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="552" mass="60668" checksum="D0A8D90DFF795AC9" modified="2014-04-16" version="1">MATTTVTGHGRRASIRQAELQIPTKSSVPQSTSSPIDKFPPYEDTIDAVAGSTRPTRSASVKYTPSEVWEPRKATFYSREYGNGSLRNPKHRPRKSISEAITTIRTRNGSMSASAHELAEVLRAPVSYRLIGLCVVWYLTSALTNTSSKSILNALPMPITLTMIQFAFVSFWCLLLVYLSTVIPRLRQSIPILQHGIRYPSRDVISTALPLAVFQLAGHILSSMATAQIPVSLVHTIKGLSPLFTVLAYRILFRIRYARATYLSLIPLTLGVMLACSTGVSTNFFGIFCAFGAAIVFVSQNIFSKKLFNEVDRAESDLQTPGQRKLDKLNLLCYCSGLAFFLTLPIWFVTEGYPLVSDFIHDGVISLSGKQGSLDHGALLMEFLFNGVSHFAQNILAFVLLSMVSPVSYSVASLVKRVFVIVVAVLWFGSSTTSIQAFGIGLTFVGLYLYDRNSHDDVADQRANTDHFRAEQSILPMNVRHPSKPWDSNGYAFPAGRVFEGALNSHAALNNSKKEDDGPGHVRPRGASLSRAWLPGTKQESTWQVSDSQAAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W6QN84</accession>
    <name>W6QN84_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S11g000046</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792025">
        <property type="protein sequence ID" value="CDM38343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QN84"/>
    <dbReference type="OMA" id="RIVIYAC"/>
    <dbReference type="OrthoDB" id="4297596at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM38343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="124" mass="14327" checksum="749056E5A979615B" modified="2014-04-16" version="1">MGFHPTRIVIYACITDIDGCPQRRHVEIGEDFCENILNRAFNPTLHPAGYDHIHIPADFDSPDPLKRWFILDLGVNEPLNQEDVLQLPHQWIENAKFRAASYTWGGKQEQKIVGNMQKVDNEME</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W6QNB3</accession>
    <name>W6QNB3_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="7">HOOK</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PROQFM164_S04g000505</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QNB3"/>
    <dbReference type="STRING" id="1365484.W6QNB3"/>
    <dbReference type="OMA" id="DAKYRKC"/>
    <dbReference type="OrthoDB" id="2129491at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030705">
        <property type="term" value="P:cytoskeleton-dependent intracellular transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22211">
        <property type="entry name" value="HkD_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043936">
        <property type="entry name" value="HOOK_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18947:SF28">
        <property type="entry name" value="GIRDIN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18947">
        <property type="entry name" value="HOOK PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19047">
        <property type="entry name" value="HOOK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116907">
        <property type="entry name" value="Hook domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90257">
        <property type="entry name" value="Myosin rod fragments"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HOOK N-terminal" evidence="6">
        <location>
            <begin position="8"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="451"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="740"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="186"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="263"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="513"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="670"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="457"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF19047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM35624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="760" mass="86770" checksum="6EBDE5EC5996898C" modified="2014-04-16" version="1">MGSEHTVTKVLLEWINSFALGKTLRTTDELTDGIILWEILQDIDPQYFLEEIPERNSSDHWVAKWQNLKHIHKLLLNYIRHQNDDILPSGLDPSPDLESIAEKASPKETNKLLKLLLIAAISSPNAGTYVQTLQELSTSTQEGLRDIIEEAHNGQYEPMDAADELREDLAKHDRPVDLELQFEERVGKVLAENDRLTHEKKELEKALGDLHNRLARLQENNDTLQNRLASTEDRLVTLKSGKGDIGHNAKALESKTRQQDDLIASQEAKLTAAQDEIDSLRMAVESLRVKNQRYQKLQDDYDELRTEKDQLARKANAAEKYRQKLQASQDFEKENQTLKNQIKDIQQQLKESDAQQRWSSERDVELEEYRKLLPQVEQECNEIQNLKKQLEFNNHALTERLESADEQHERDDALISELRERLGEIDGLPGSASPGSETPKMQGTLHKDFEALGVKESQLKSEDDLKRETESVKAPSAPASHTGGFSENFTASVQLARSGSTQSDDYWKLYENYTGALKKIAEVQDTLETAKRDLSDTQAELGLVNAEQVEMLQGLEAYNSAELAKVRDDWEALTQNVHHLEAEVDASQTLVREVCAEREELRKMLDNKQSEISSEDQEVMNEMQMLLGEFETHNNEGGEVPQKSSFELLKQCAGVLEKNVERLAQRAEYIQQQNELVKSLRERMKNYEENLDDGISKERELELQNIIDSQTRELNLVGSAWYHLQSRWQNNNMTVSRYRHGASTGDSKGWLAKQRSAVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W6QNH1</accession>
    <name>W6QNH1_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S06g000463</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792020">
        <property type="protein sequence ID" value="CDM37501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QNH1"/>
    <dbReference type="OrthoDB" id="5552418at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM37501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="85" mass="9666" checksum="EA35B75C9D7CAE3F" modified="2014-04-16" version="1">MLEVIATGQQPAHTSLIRRDRLEAMGRDLIQLCDQLEPHGLVDYQMGIWEEEILSVLGQCLDLMDSRPDLHHIPVRPEATTVPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W6QNJ3</accession>
    <name>W6QNJ3_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S02g001367</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QNJ3"/>
    <dbReference type="STRING" id="1365484.W6QNJ3"/>
    <dbReference type="OMA" id="IWASAGK"/>
    <dbReference type="OrthoDB" id="72269at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050562">
        <property type="entry name" value="FAD_mOase_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47356:SF2">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47356">
        <property type="entry name" value="FAD-DEPENDENT MONOOXYGENASE ASQG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="208"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="256"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="288"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="321"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="369"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="425"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="456"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM31217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="496" mass="54724" checksum="AE58DCBB21013F78" modified="2014-04-16" version="1">METAASLTNHLVAALKNSQSGTLSSAEISKIFEGVQQQREKRAWGLIKVSHARQRLECLETPFLKFIARYVVPRFSKSTVLSKWIDTYSPAVSLDMLPLPHRPREIAYFDERSRTPSSRGVVSILLYAAYFLLAWLGHRQLSAAIRANGTMGFVRQSIQNQSVQLPGGIEAPLRQVYTGIRPVDLILKVMVAIFLPAVSNFSKPEQPFQVLYFLGSMMPIIAIWTVEGFRPRNKWTLLAIPSLWAVLYQLRGIGLIAPLFFISSTYVSSGIAYFSPSTRTLPESTARAILPALILGFVVPTMMLFFPLADAPNTRQVFIALWQPAPVYVLILTHIFSRVIKSISSSTPAKTDSSAAESKPNRDIPHLQTLYAVAGGVSACFHVALLLSWAALGTGFITRAFIPSDAFAQVATLADGVFVFFQNDFLLVSVATLLWCLASVWDLYRIGVSNVSWQVALAGLILGSVAIGPGATVAAVWYWREEVMSRISFRRHGLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W6QNJ7</accession>
    <name>W6QNJ7_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Zinc finger, C2H2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PROQFM164_S02g001372</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QNJ7"/>
    <dbReference type="STRING" id="1365484.W6QNJ7"/>
    <dbReference type="OMA" id="VKHIVCP"/>
    <dbReference type="OrthoDB" id="8117402at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24376:SF235">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24376">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24666">
        <property type="entry name" value="zf-C2H2_fungi_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="62"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="140"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="209"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="236"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="257"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDM31222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="461" mass="50034" checksum="F7E971ACB9945A46" modified="2014-04-16" version="1">MAEEPEEVSCTFQGCRLSFKSAGEMQYHKANADRHSYCMKCDLDFQSQQALHLHKIMSDRHFACPECCLELRSEAGLEVHMRNNHQEGREVACMGCGCTYNSASAVIKHIEDKGCPVLMLPEKTRDATSQDLPSAAAILSMGRHSPGPQYPPSEASSEDQDTDGGVPLDFSTPRMEGKRPARDTNYASFSLDDWPELGTPATPVKGKEGSSSTESSGGARLDDLLSYDSPSPSPRGATNQSSEAGSTLAVQEAGPSHHTRSTRGRATAHRKIQGVDPESFWNHEKSRYYCNCGASFLYLATFEYHLTMEDETISDCPRCFKRFKTLAALVAHMEARYSKCAFRVTTGQIEQELSEVTRGFADISRMIGDDETELGEIDFDVSSQPENNTTGASDADAASLSADDVSLNAVAISLDADDVASNAAAVSSNAGAVSPTMESLVSDWEGLVFSDAHEENDKEDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W6QNT8</accession>
    <name>W6QNT8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="6">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PROQFM164_S04g000625</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QNT8"/>
    <dbReference type="STRING" id="1365484.W6QNT8"/>
    <dbReference type="OrthoDB" id="3066029at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF152">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="32"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDM35744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="142" mass="15459" checksum="AE4CB74513849C46" modified="2014-04-16" version="1">MHDGQPGQAGFSSFIWGPITNLFGRRNTYNTAILVLYTCSASTAAAINLYIFIAIRILGGFTGSFQQKKCIANRISSMEKERKENKCKNNNGVFITLRGQSPILIYPRRKTVRGTAADCFMVGSVSGPAIGPYIGGIIVIFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W6QNU1</accession>
    <name>W6QNU1_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PROQFM164_S35g000001</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="HG792049">
        <property type="protein sequence ID" value="CDM38609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QNU1"/>
    <dbReference type="STRING" id="1365484.W6QNU1"/>
    <dbReference type="OMA" id="IWDIMGQ"/>
    <dbReference type="OrthoDB" id="5979581at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050684">
        <property type="term" value="P:regulation of mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051334">
        <property type="entry name" value="SRPK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634:SF9">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="49"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDM38609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="442" mass="49879" checksum="BB52DE450124A320" modified="2014-04-16" version="1">MAFKTFSSSADSGPLPFKYVPIEEVERLEKYQPGGYHPILIGDILRSRYRVAHKLGYGAYSTTWLCRDYQSNTYVAVKVGTADSNDREVDVLNYLNHSTPLDHPGRTMIPSIKDRFVLHGPNGTHPCYVTTLAMCSVSSAKEGSYKRIFQAMTARSLIVQLLLAVEYIHSKGVVHGDLHIGNILLCLPADFDQLSIEELYEKYGSPASEPVIRFDGQPLESSVPSSVVPPIWLGKASEEFSLPESRVLLSDFGEAYRPSTDYRYNSHAPMSFVPPEARFESECGLSFSADIWTLACSIWIILGQRPLFEDILATPDDITAEQIDTRGNLPLRWWEKWAARHKYFDESGKPNQGRQVRSWEDRFEKHIQLPRQQAGIQGFDLEEKAAVMNMLRSMLSFEPEKRPTAQDIVKCEWMERWAIPDFNKSHLGGAGAADNSRDAVPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W6QQ62</accession>
    <name>W6QQ62_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Carboxypeptidase</fullName>
            <ecNumber evidence="6">3.4.16.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PROQFM164_S05g000032</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the peptidase S10 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.-" evidence="6"/>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QQ62"/>
    <dbReference type="STRING" id="1365484.W6QQ62"/>
    <dbReference type="OMA" id="CTEAANM"/>
    <dbReference type="OrthoDB" id="443318at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000125">
        <property type="entry name" value="Carboxypeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018202">
        <property type="entry name" value="Ser_caboxypep_ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF131">
        <property type="entry name" value="CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00131">
        <property type="entry name" value="CARBOXYPEPT_SER_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6 8" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5006531565" description="Carboxypeptidase" evidence="6">
        <location>
            <begin position="23"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="520"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="526"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM36199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="558" mass="61813" checksum="62B14C80A2980D25" modified="2014-04-16" version="1">MRVSHWIPLLPAVAALAVPSDSLEGLEALIRRQLPKHPTHVKTIKTANNVTIRYKEPGKEGVCETTPGVNSYSGYVDLSPTEHTFFWFFEARHDPENAPITLWLNGGPGSDSLIGLFEELGPCGVNKNNESYINKNSWNEVSNLLFISQPLGVGFSYAEKAAGTLNPITGSYEDPSFAGIDGRYPVINATAIDTTVLAAKATWEVLQGFLGGLPKLDSKIKSKSFNLWTESYGGHYGPAFFDHFYEENLKIANGTQHGIQLDFNTLGIINGIIDEGIQARHYPEFAVNNTYGIKAVNETVYNYMRFANEMPNGCQDQIATCKLTNRTSLSDLALCTEATNMCRDNVESPYYVFGERGAYDIRHPSDDPTPEGYYINYLAKDSVLNALGVDINYTQSNNEVYFAFQQTGDFVWPNFLEDLEDILSRPVRVALIYGDADYICNWFGGEAISLAAKYKHSKQFQKAGYAPFLVDGVEYGETREYGNFSFTRVYESGHEVPYYQPVAALQLFNRTLNGWELTKGEDKVKQNSGSTGPKTATHTQASVPLPTATKASGFGELS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W6QQC8</accession>
    <name>W6QQC8_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7770 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S05g000087</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QQC8"/>
    <dbReference type="STRING" id="1365484.W6QQC8"/>
    <dbReference type="OMA" id="ASWMESG"/>
    <dbReference type="OrthoDB" id="3527137at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056672">
        <property type="entry name" value="DUF7770"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24968">
        <property type="entry name" value="DUF7770"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7770" evidence="1">
        <location>
            <begin position="38"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM36254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="191" mass="21458" checksum="D5EB0029893D3E11" modified="2014-04-16" version="1">MRVVEVISSFTITLVEMNDNFDADYLNPKDLQAQVSHIHISGYINPNNEGDEDGNPPTNHWAAFLQFGDTGSVRIDMAPGYGDDGLRGKIDISSKSYTSTNNAIKTLTFTVEAYATVQTITELSILNGHDRYMFTEEWEGCRFWIYTFIEDLESAGLISEGSGQTAWETVSLYWQNPSGSEPRQILQGEFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W6QR15</accession>
    <name>W6QR15_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S05g000347</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QR15"/>
    <dbReference type="OMA" id="LTSHGMH"/>
    <dbReference type="OrthoDB" id="10350997at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM36514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="108" mass="11453" checksum="F26A9A3412CDC42E" modified="2014-04-16" version="1">MSPSILPGSSLRQKTKRSKPGRSPALVGTGRELLTSHGMHSAQSMAVNKRYGGYTIDCANGFGIQPLPSAETSARMAMANFDASSDPLANADRVIINGWDESMAETIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W6QRI4</accession>
    <name>W6QRI4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Probable transposable element</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S31g000001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792045">
        <property type="protein sequence ID" value="CDM38602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QRI4"/>
    <dbReference type="STRING" id="1365484.W6QRI4"/>
    <dbReference type="OMA" id="HRAQNTI"/>
    <dbReference type="OrthoDB" id="4368687at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09276">
        <property type="entry name" value="Rnase_HI_RT_non_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481:SF1">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481">
        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14529">
        <property type="entry name" value="Exo_endo_phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="478"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="domain" description="RNase H type-1" evidence="2">
        <location>
            <begin position="950"/>
            <end position="1097"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM38602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="1266" mass="142997" checksum="ACD1D0856A26B2B8" modified="2014-04-16" version="1">MEALINDHQSQDLDVLLIQEPSITTYQTHVNHSAWRLYRPITETDAGRFRSLIYINRKVSTSSHRQIACDHPDVTAIKIWTADSQFLIFSVYLSCVPLFTPNEASAELALTAIQNTITSNIQEDQRITTVILSGDFNRHHPAWSTNHIQPQFIEDASELINFFQTHGLHGCLPRGTATFWPLNDPGKSTTIDQTVTNRPELLIKCHLYHENYGSDHRATYSEWNLSPRRQPAAKAKKAYDRADWAKIAEDVLRQIGPWKEVKTRPALDEVVERLTEATATAVDRYTPDLRPSPYSKRWFTPDLKIQQTEVNYLRRKWQESCAELGRHDARSTTLFQEMQQKRRIWTRTIEKVKASHWKQFLDEAGEGKLWKAAIYTKPREAWGCIPALHVATNELTENKEKAQAFLDAFFPKMDEPDEDSLIRAPLELPWQPITELEIQRSLKSAKGSTAPGEDGVPTLVWKQLWGYLKHYITGIFTASISLGYHQKGWRSAKSVVLQKPKKPDYSVPGAYRPISLLNTLGKLLEAVMARRLSYLAEKHGLLPDTQFGGRPGRTTEQALLVLSNAIDRAWYKHKVVTLVAFDLKGAFNGVNKVSLDACLRARRIPTVARKWIASFMSDRHASIGFDDFRTEVTPLANAGLAQGSPLSPILFAFFNSDLVDQPVTFHGGASAFIDDYFRWRVGRSAEDNLAKIQSEDSPRIKAWARQTGSCFAAEKTELIHITRKRSQQLQGQVVMNGKTVEASPTAKLLGVVFDQELRWKEHVQQAIKRAIKVSIALGGLRHLRPEQMRQLYQACVTPVVDYASTIWYDPLRDKTHLRHLNTVQRTTLIRILSAFRTVATTTLEVEAHVLPTHLRLRHRAQNTIASLHTLPRDHPIWDTLRRAQKRRNNIGSYARFPLAEALKTMDLVRLDELETIDPRPLPPWRAEPFTEIEIGSDRESATERAGTVRSMSTIVVYSDASGREDHLGAAAVALGNNLEVIESQQVQVGPMDRWSVHVAELIGIFYAVSIVFKISNQRPRTEHKGKTTATILCDSRSALQAIQNPGNKSGQCIIHAILQAATEVQAKGIALRLQWIPGHCDNPGNDAVDRLAKDAASPGKTHPFRPLLTRTKALIRDNIRAQWEREWESSTKGGHLRKIDSTLPAAYTRKLYGNLPRGRAYLLTQLRTGHNWLSTFRNAIGFRDDDHCACGAQETVTHVLVDCPKLQELRRELRMKVGDAFNSISSLLGGSKEGERGKPDTVSRTKTVNAVLDFAEASQRFQSRAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W6QTW1</accession>
    <name>W6QTW1_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S02g003128</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QTW1"/>
    <dbReference type="STRING" id="1365484.W6QTW1"/>
    <dbReference type="OrthoDB" id="3254104at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="260"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="292"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="320"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM32977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="370" mass="42614" checksum="F0A9CFECF3791810" modified="2014-04-16" version="1">MIYLENRVRPNGTHLIALFQAAIQYILEDISYPFDFVEATRKDRPVSLYAELHLAYYLEIGHRANLLLSGLAATILSALFIDHYVPEMLEASKSYRRGSVISRSHILFRRKWRSRLDNSIKSNSYCLDVPLGNIPYTIDTVEVIEDYRDIIILYISSGRIARDMLLGRSYLHCLFTNLIKRNESFLKDQRLPSILQPAQLTIANMVTQSPSYPDTQVVGSTYEPFESSYMRMIIEVDGISYLADNEAGEWILNTIQNPPLLAMVCVLFVSGLAIMSWLFWEYWGNYIWLTNRIFVPILLNALAGFLTTIISLYTAHDGDWSIMVLLTVITSGLSVACSLILLYIYKFGKLERLKQEHNLMFRNYEHPLHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W6QUH7</accession>
    <name>W6QUH7_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Altered inheritance of mitochondria protein 9, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Found in mitochondrial proteome protein 29</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PROQFM164_S07g000102</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AIM9 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792021">
        <property type="protein sequence ID" value="CDM37754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QUH7"/>
    <dbReference type="STRING" id="1365484.W6QUH7"/>
    <dbReference type="OMA" id="WGTLKLP"/>
    <dbReference type="OrthoDB" id="2831558at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051035">
        <property type="entry name" value="Mito_inheritance_9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36091">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36091:SF1">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="7">
        <location>
            <begin position="278"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM37754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="453" mass="51594" checksum="E51A9234B2A99255" modified="2014-04-16" version="1">MLYSHSDWNSDDEFFKFTRSRFLVDEAENLRRREIKFNLNRLASVAADSIGAAQCISIIKYPDGMFNKTFLMTMEDGREVVAKVPNPNSGIPHFTMASEFATTDFVGLFETRSTPNLANATGLGGSQKSSTHQHVMSRLKVILAMTSLRKQWLSVSFSHYGSLYYARDVQFPAGNHYVKDGMAVKDSEFAIGPATGRDWFDAGRSILDIERRPWASPTQYLQAVGTREIKAIQFLKPPKQTALFCGPKLHQPDAEKKLTALAWYQKIVDAIIPKDTSITNPYLWHDDLHDDNIFVDPDNPERITGIIDWQSCRISPLISHNLDPAFLDWDGLEPETLDLAPRPTLARLSPDERSAAMHEYTVQNVFIGWRNLMRAKNPDLYRVVEFRKTAAFGLIFLAHRMFEYGEPHFLSLLVDLKDMWADLPGVISDIPFPFEFSETDLERIKLDCDKSTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W6QVL5</accession>
    <name>W6QVL5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="10">TRP-like family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PROQFM164_S09g000080</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transient receptor potential (TRP) ion channel family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792023">
        <property type="protein sequence ID" value="CDM38164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QVL5"/>
    <dbReference type="STRING" id="1365484.W6QVL5"/>
    <dbReference type="OMA" id="DIWAGMM"/>
    <dbReference type="OrthoDB" id="5312224at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010308">
        <property type="entry name" value="TRP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040241">
        <property type="entry name" value="TRP_Flc/Pkd2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032800">
        <property type="entry name" value="TRP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31145">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_7G01610)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31145:SF6">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_7G01610)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06011">
        <property type="entry name" value="TRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01320">
        <property type="entry name" value="TRP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="258"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="393"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="439"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="467"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="549"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="581"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="612"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="domain" description="ML-like" evidence="9">
        <location>
            <begin position="71"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="666"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="723"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="860"/>
            <end position="1117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="20"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="744"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="834"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="945"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1010"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1020"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1032"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1054"/>
            <end position="1067"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDM38164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="1117" mass="121248" checksum="1B622F6F70D4D7B6" modified="2014-04-16" version="1">MPEVDMHDSTEIELDGHSSSSRRKASRRPRRSGLHILQGRPWPDTSKRRAQPWSSVWWIALLYLVSFASPGAAVLLDFENCLSKSILESDPLQLQFVPTNVSVKFNLTNPLHPLAITVYGNVSGTTSQTADYPAPDSSVWTNPNWTDGKIEDVSTTNNKYSTLMTDLNVLSFTPFSNASRFRDAVTQGTLPLGPVFNYNMSDLTTLRAFSVQHDMLSTYRFGTITPLLIVRSGDASAVQLACVLVNATPDLGTSLKSAIAYVPLIILILVGIATITAAMFSPWGTTDLFRWTSNYGRDEDVLRLVTPGFADCLQYLQFIVLTGSLSLNYPGFFQPIVSQGAWSTLMFNQSFVSTEIGRDPVVDGLYAINGTYGLDRMNHLVGMASSQDIWPGMIIWVLVIMACVTVVFQIAFALRWLYRELANNTDQDLRARNMPFTMGNLIRIVFNFLLLPIVSLSFFQLVIARQSTAYCVALAAVVIVIIACFAIWAIRVVLNTRPKAHLFDDLPTVLLYGPLYNTYCDDAAAFGIVPIVLNIARGIAIGALQPSGIAQVVMLAICEVVSVLTLLAFRPFSRPTHMNLYHCLFSIVRFLTVILSVVFVPSLTLSDAARGWIGYLILVLHAVVLIFGFFLNAMQTLIEVLARLAGAGGATRGGLTKVLGMRQLSRRTPRRDLTRQSMGSEAAMLGHGDDRMSSQFDGSRPRSLSGSSGLLLNRASDGRVSTIYDYPSSQGGTHSRAASGGFPTPTSTTYQGAGFPSSPSSGKMMGTNPRDPYYRPPRPGRRTPPASGALAKGKSPSRGFLKSKSSRRAVSIDDDLGDGMSGRATPVPAYLATPKDDMELDTPRKPKDYAVREVDFYYGVRGPPLSHSGTRKLKTGPADPTGPVSSATGWFRSLLQGKTKDNAKGFEVVRSARAPPPGLFPRRDDFNDPYQDDIGMPSASHSREVSTGNVPYQDSDNDHDPEPSCPPVLPQINTSGGGGIELPSRTASCHTQAPGDQDAGTAAGLPVVTETLSHNSDISQHYEHSEHHLQPEGSTTARLPFSGSSSPSRERGLSMTSTSRSRSNASSQQTGARPSSLGYVPQHRAHDHIHEGSPDEPSFKGSAAELVDEASLGGHER</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>W6QYD9</accession>
    <name>W6QYD9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type DNA-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PROQFM164_S03g001291</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QYD9"/>
    <dbReference type="STRING" id="1365484.W6QYD9"/>
    <dbReference type="OMA" id="IMRGFAH"/>
    <dbReference type="OrthoDB" id="3266505at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF6">
        <property type="entry name" value="PROLINE UTILIZATION TRANS-ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="11"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="71"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="91"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM34567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="720" mass="80494" checksum="FEA356239F48DD31" modified="2014-04-16" version="1">MAGSSPRSTNACETCRKRKVKCSGDKPCRACIKHNWECTFGHSGRRRFSEAQVKHLLEKVRTYEEQLSSQTVGAPVSSFHSSVVPDETPGRQSAQRSSSSQRQTELLYTDNDPSISPGNLTSLSSSWSACKYELTLHEATDLTSGPAFESQVRSLLDRSHSSDRSFHGSTSNFQYRADRLPQWASVKELVDNVAGVAFPSLEESQHLLDQFLFYLGVSQHFFDPRSFSDDLMLLFQSPETRQQQINSPWFTEYLLVMAMAKLMDVKHPTSQTPGTDLFAEALKRLPPLHHMGGEGVVAVEILTLIATYLQWCDHKHDAYLYIGLALRLAIALGCNLREVDQRCLPSQSAHRLRLWWTVYMLDRRLSSGLGLAAGADERQLRTELPRNAMGFQSPVALAINVRIARVTDDIMSTLYGNKSITQLELVQKIQGILQELHDTGRSFPKSLVLDFNRPLQSVTRTGASLYLMLFQAIILCTRPILLQRARFEAQSQQQSRSTEPAPSMLLRLCDTCDEAATRSLAILESLRLQQTIPRYGFFDLDATFSAAFVLVMVGFLDKSQSQPPPALDQASNVLRFLSKSGNLAAERRLQDIAQSYSHVWPNHVFDANTSHSDAATRDTTQTYTISLGPRQDALLASSDPPPYMTVASGGRGDHQDEISLLEPWSNMDVPDAMFDMQGDWNLDLSGEAEGIYSSFHNPTLPLTGVDYIDWLEIEKVFNGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W6QZ08</accession>
    <name>W6QZ08_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Methyltransferase type 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S03g001479</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QZ08"/>
    <dbReference type="STRING" id="1365484.W6QZ08"/>
    <dbReference type="OMA" id="YLAFADH"/>
    <dbReference type="OrthoDB" id="66144at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030798">
        <property type="term" value="F:trans-aconitate 2-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.290">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023149">
        <property type="entry name" value="Trans_acon_MeTrfase_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002463">
        <property type="entry name" value="PRK01683.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43861:SF1">
        <property type="entry name" value="TRANS-ACONITATE 2-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43861">
        <property type="entry name" value="TRANS-ACONITATE 2-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="3">
        <location>
            <begin position="39"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM34752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="262" mass="29676" checksum="2A87C72A85C31EEC" modified="2014-04-16" version="1">MTQQTKDWSANQYLKFENERTQPARDLLSHVPLTAPRRIIDLGCGPGNSTTVLATQYPSATITGLDSSPDMIKRAKKVLPDHDFQIADLSTYTPDPATPVDLFFSNAVFHWLKADDRIVVIKRLLQPQQEGAVFALQVPHNLNEPSHLLMRETAAEGPWKEKLAGVQRDGFQSPQELYDLLKPVCSRVDVFETSYYHSLESHEAIIEWVKGTGLRPFLEPLVDGEEEAFLADYLRRLRAAYPVSFDGRVLLKYPRLFLVAVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>W6R1W1</accession>
    <name>W6R1W1_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 15">Chromatin-remodeling ATPase INO80</fullName>
            <ecNumber evidence="15">3.6.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">ino80</name>
        <name evidence="20" type="ORF">PROQFM164_S04g000683</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">ATPase component of the INO80 complex which remodels chromatin by shifting nucleosomes and is involved in DNA repair.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="15">Component of the INO80 chromatin-remodeling complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="15">The DBINO region is involved in binding to DNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.-" evidence="15"/>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1365484.W6R1W1"/>
    <dbReference type="OMA" id="NLLGFHC"/>
    <dbReference type="OrthoDB" id="372624at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060255">
        <property type="term" value="P:regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18002">
        <property type="entry name" value="DEXQc_INO80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000006">
        <property type="entry name" value="Putative DNA helicase INO80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001269">
        <property type="entry name" value="SNF2 family helicase/ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020838">
        <property type="entry name" value="DBINO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031047">
        <property type="entry name" value="DEXQc_INO80"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050520">
        <property type="entry name" value="INO80/SWR1_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45685:SF2">
        <property type="entry name" value="CHROMATIN-REMODELING ATPASE INO80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45685">
        <property type="entry name" value="HELICASE SRCAP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13892">
        <property type="entry name" value="DBINO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51413">
        <property type="entry name" value="DBINO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0010">Activator</keyword>
    <keyword evidence="7 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 15" id="KW-0227">DNA damage</keyword>
    <keyword evidence="13 15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="10 15" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="20" id="KW-0347">Helicase</keyword>
    <keyword evidence="6 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="DBINO" evidence="19">
        <location>
            <begin position="554"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="17">
        <location>
            <begin position="808"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="18">
        <location>
            <begin position="1383"/>
            <end position="1543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="377"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="575"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="691"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1288"/>
            <end position="1308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1597"/>
            <end position="1664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="8"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="377"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="397"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="495"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="594"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="1632"/>
            <end position="1648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="1649"/>
            <end position="1658"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU368001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CDM35802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="1664" mass="188316" checksum="75B5AF7B666FEF15" modified="2014-04-16" version="1">MTGPPPYNAQSPTQQQRYPAYTSPNKNHPYYPSNEPPQPPQQYHQHPPQTPPAFGPSSVARSPHFSHASPMPSTLPPPLNGSAPHHPSHLESSQYQGHSAPGSQLPLPRPYSSSVMAGNGASPYGSATPHGHPPSHPEGHSQSPTRESESPYRMRGNGIGYGPPMMREPRPASPQEAKPARAADPMSFASILSGPSDDQPARKPSPLPVPMISSHTPHAPPVFIHRHLEHTTPVAIHHKHEHRLDFDRHIDGPRPPHATNGFVKPDAEYAAPIPRAPLRKPFPPGVDLEQVNRASAEIDHAEKSDVEDPGFDAEQERYREKGYKRSLESSRAEEVRRKRRRNEFLIDLGRSFERQAILGTERFRVLNEGAVMAEVQQKEIQDEKERKKDMQRKRRRENTVRQEMQKKLEAERKASKAQEPGERAKFLREAERAQKKIRTTKRALEGGDGQDELGEVTPLAPNLEGGTTSQFHIGRSSPSRRRSGRAGPVTRPKKSKEQKQAEKDLAEAAWNAGLDDELYLTPSARKDVRRSKEGTPISQLHYDSKGYNQIYEQIWRDIARKDIPKVYRIKTSSLSTRQENLRKTAQLASKQSRKWQERTNKSTKDTQARAKRTMREMMSFWKRNEREERDLRRVAEKQELESAKKAEADREANRQKRKLNFLISQTELYSHFIGRKIKTDEAQGDSVVTATGETIQPGKPNAHTINLPDSVANPNAKTTAFEDLDFDAEDETVLQQAAMANAQNAVQEAQDRARAFNNQGEGDNMAAFDDGEMNFQNPTSLGDIEISQPTMLNAQLKEYQLKGLNWLVNLYEQGINGILADEMGLGKTIQSISVMAYLAEVHNIWGPFLVIAPASTLHNWQQEITRFVPNIKVLPYWGNAKDRKILRKFWDRKHITYNRDSEFHVLVTSYQLVVLDAQYFQKVKWQYMILDEAQAIKSSSSSRWKNLLGFSCRNRLLLTGTPIQNNMQELWALLHFIMPTLFDSHDEFSEWFSKDIESHAQSNTKLNEDQLKRLHMILKPFMLRRVKKNVQQELGDKVEKDIFCDLTYRQRALYSNLRNRVSIIDLIEKAATGDDTDSSTLMNLVMQFRKVCNHPDLFERAETKSPFSAASFAETASFVREGNFVDVRYSTQNLIEYPLPRLLCSSTGRLDLPGSDNPRVGFQTKYLSQLMNVWTPENIQKSARDNGAFSFLRFIDTSAGEASEMARLGVYERAERRRSKPNRLSALNVIYDESDDPKNSVLSHSMLNIVDRNDQQAVRDVAIEGRMKDLMTVSRSSFEDQGLQLIEPCSSPKASAPPITMSSSGQQTTRETYQALFNPSVRQALSGHCSRQLEEQILIKKLDPTPYSHAPMLPPPVSLKGRYSHIEVPSMRRFVTDSGKLAKLDQLLRELKPGGHRVLLYFQMTRMIDLMEEYLTYRNFKYCRLDGSTKLEDRRDTVADFQSNPDIFVFLLSTRAGGLGINLTAADTVIFYDSDWNPTIDSQAMDRAHRLGQTRQVTVYRLITRGTIEERIRKRALQKEEVQRVVITGGASGGVDFNTRARENRTKDIALWLADDDEAELIEQKEKEAIERGETLGAKGGKKAAQKRKRDLTLDDMYHEGEGNFDDASAKPSGAATPAEEPVEVPSATPAKRGRGRGPGKGTSKRAKTTKERLRLIDGDGGLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W6R3U9</accession>
    <name>W6R3U9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Amino acid transporter, transmembrane</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PROQFM164_S05g000310</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6R3U9"/>
    <dbReference type="STRING" id="1365484.W6R3U9"/>
    <dbReference type="OMA" id="IYAGYNI"/>
    <dbReference type="OrthoDB" id="655540at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF8">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="42"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="116"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="173"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="224"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="260"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="303"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="347"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="375"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="408"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="7">
        <location>
            <begin position="36"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM36477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="452" mass="48136" checksum="B005A19F6528AC62" modified="2014-04-16" version="1">MDKLPNAMATEALPKDQDLADPELQGILEGNARFRRLGWKRLTVISIVEAIALGSLGLPSAFAALGMVAGVILTIGLGFVAIYAGYSIGEVKLRYPQVGHYADVGQLLLGNVGSKIFVGSFVALLIFVIGSHCLTGAIAFETITQSSSCSIIFSVASAAILMLLAIPPSFAEIAILGYIDFASILVAIGVTMIATGIQSSNGSGGFAAADVLAWSAWPKPGLTFSAAIVATNNIVFAYSFAGCLPSFMEDMHTPEDYVKTLWWLGGIQIVIYTLTGSIIYAFVGQGVQSPALLSAGPIVSRVVFGIALPVIFISGSINTTVVCRYIHGKVYRDSAVRFVNTSKGWSTWLGLVFCVTILAWIIAEAIPIFSELLSIISALFVSGLSFYIPPIMWYMLLKEGAWYEKHNLKPAILNGVVFLVGMIIFGCGTYSSVAELIDKFRSGSVSKPFTCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>W6R453</accession>
    <name>W6R453_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Chromatin modification-related protein EAF3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Chromatin modification-related protein eaf3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">eaf3</name>
        <name evidence="15" type="ORF">PROQFM164_S05g000415</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Involved in deacetylation of histones, chromatin assembly and chromosome segregation. May act as a transcriptional oscillator, directing histone deacetylases to specific chromosomal domains. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MRG family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6R453"/>
    <dbReference type="STRING" id="1365484.W6R453"/>
    <dbReference type="OMA" id="GLQTYFD"/>
    <dbReference type="OrthoDB" id="124855at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032221">
        <property type="term" value="C:Rpd3S complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.274.30:FF:000004">
        <property type="entry name" value="Putative Chromatin modification-related protein eaf3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.30">
        <property type="entry name" value="MRG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008676">
        <property type="entry name" value="MRG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038217">
        <property type="entry name" value="MRG_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026541">
        <property type="entry name" value="MRG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053820">
        <property type="entry name" value="MSL3_chromo-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10880">
        <property type="entry name" value="MORTALITY FACTOR 4-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10880:SF15">
        <property type="entry name" value="MSL COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05712">
        <property type="entry name" value="MRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22732">
        <property type="entry name" value="MSL3_chromo-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038133">
        <property type="entry name" value="HAT_Nua4_EAF3/MRG15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51640">
        <property type="entry name" value="MRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Chromo" evidence="14">
        <location>
            <begin position="21"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="90"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="98"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00057322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00072864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CDM36582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="308" mass="35985" checksum="12614ED64DFA9C19" modified="2014-04-16" version="1">MAPISMYSKDEKVLCFHHEILYDAKILDVRHKDSTDKKSPFEYQVHYKGWKNTWDDWVLEDRLRKHTEDNRELASNLRREAEASFRLKNTKITAKKRAGSDRDSVRDSEERGSVPSRGTKRARDSEIEKEESFNIRPSVRVVMPDNLKSLLVDDWEQVTKNQCVVSLPAKYPVRQILQDWHEEELPKRSGSSADEDVLEEVVAGIQEYFDKCLDKILLYRHERPQYRGLRKKFEAATGELADKGPIDVYGAEHLIRLFSTMPELIAQTNMDMQATNRLREEISKLSMWLSKNSEKYFATSYQPAESTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W6R4Y9</accession>
    <name>W6R4Y9_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PROQFM164_S05g000720</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6R4Y9"/>
    <dbReference type="STRING" id="1365484.W6R4Y9"/>
    <dbReference type="OMA" id="HRYRQGG"/>
    <dbReference type="OrthoDB" id="5979581at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050684">
        <property type="term" value="P:regulation of mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051334">
        <property type="entry name" value="SRPK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634:SF9">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="68"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDM36887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="418" mass="47922" checksum="89302CB56C63BB72" modified="2014-04-16" version="1">MAIPWRISSRAIPPRSIISPLYIISRNMSTQMDQRLYISTVDAEPLHRYRKGGYHPVTLGEYLKDGRYKVLHKLGWGGYSTVWAARDQREETYVAVKISVAETKYDMRELQTMKELASYHPHTVQLLDNFDLKGPNGSHKCLVYELLGPNVPDTIDTRFPDGRLPGKLAKVIAKQCLIGLDGLHQRTIGHGDLHTRNLAFTMPYIDDLSEERFIRMLGKPDIGFVQKRENCDRKCLELGIPEYIVRPASRQTLWNPAQTVKILDFGESFLHTTIPKTLHTPLSLRAPEVIFRDRIDHRVDLWSMGCMLFEVFAGQPPFDTFLITPTILVDQMREMATDSLPKRWQGVWNTMNAEEGIESSGPNLQEWLEDVYFNSPLSPDLTREDIVRLGQIVGRLLHFEPSARASARDVLNDPWLNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W6R520</accession>
    <name>W6R520_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Rhomboid family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PROQFM164_S05g000755</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6R520"/>
    <dbReference type="STRING" id="1365484.W6R520"/>
    <dbReference type="OMA" id="EIHFWEV"/>
    <dbReference type="OrthoDB" id="73612at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1540.10:FF:000004">
        <property type="entry name" value="Transmembrane protein 115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013861">
        <property type="entry name" value="TMEM115/Pdh1/Rbl19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13377">
        <property type="entry name" value="PLACENTAL PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13377:SF3">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08551">
        <property type="entry name" value="DUF1751"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01160">
        <property type="entry name" value="DUF1751"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="45"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="73"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="102"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="174"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="325"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="358"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM36922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="368" mass="39861" checksum="0BF6FB9B9A00589C" modified="2014-04-16" version="1">MSLRINLPPATRICLVSLLTLSLLYNIARWRQIDTTGGTPTTSPLVPYLTLVPSFFFYYPWTIVTATFVEQNIFTVLLNAATIFYGGKYLERAWGSREFSKFIAVVAVIPCIAIIPVYLIWGAVGGSSSRALTQICGGVSIQASFLVAFKQLVPEHTVTIFKGIIKMRVKHFPALFLLLNSISGLAIGTDTAAVLSWLGILTSWTYLRFYKRQPDLTGTSNGTGIKGDASETFAFACLFPDVMQPPVAFVADQIYTLLVTAKLLTPFSADDIASGNELVLARGEAGLPTLLNNQRGARGAGKREEAERRRAIALKALDRRLQAATIGRVQSPGLGEPSSSMPRPTTPNPTAPAGQSMLGETSYNPDHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W6R5B3</accession>
    <name>W6R5B3_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Geranylgeranyl pyrophosphate synthetase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S05g000845</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM37012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6R5B3"/>
    <dbReference type="STRING" id="1365484.W6R5B3"/>
    <dbReference type="OMA" id="VASKWDM"/>
    <dbReference type="OrthoDB" id="5393654at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35179">
        <property type="entry name" value="PROTEIN CBG02620"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35179:SF2">
        <property type="entry name" value="START DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM37012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="421" mass="47064" checksum="DBE131FCFDEB993D" modified="2014-04-16" version="1">MSPQGRGRGRGRGRGRGRGQWRGRGGVYAAQTSSPAPPLGDIIVTIYHNEIESPAPDQDEDISRITNSQYLTSYNWLGGKKRKIIVPGEPPKWTPLSDSPALPQDRGDYYRDRNAARYPTYPLEPMVQAILTDNPEFPITSVDIIGCNSTMGNLRRFASGQGKPFRMLVEVLGKTVFFIRRENSPTEVFPDIHGYGHTFPEAYTTWNASVGGSLSHQRVMKYDFAGMQCLVRFEGDGFLPDLVLDTETEGHPVTPKDSIDPEALLSIEKVTISGYPSAITEMAPEQLDIARQGRRIPQCAVFDLKTRSRAKKGSDIIEEELPRLWISRTPNFILAHHTAGRFKHIQVRDVRDDVKQWEETQQPALGKFASLLQMIVEFARSADNGKLEIEHEEGEQVLNLREQGGVVHGVLSPAVASKWDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W6R5M2</accession>
    <name>W6R5M2_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Exocyst complex protein EXO70</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">exo70</name>
        <name evidence="6" type="ORF">PROQFM164_S06g000072</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in the secretory pathway as part of the exocyst complex which tethers secretory vesicles to the sites of exocytosis. Also plays a role in the assembly of the exocyst.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Bud</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Bud neck</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the EXO70 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792020">
        <property type="protein sequence ID" value="CDM37112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6R5M2"/>
    <dbReference type="STRING" id="1365484.W6R5M2"/>
    <dbReference type="OMA" id="GIIRAGP"/>
    <dbReference type="OrthoDB" id="1922221at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005935">
        <property type="term" value="C:cellular bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.170">
        <property type="entry name" value="Exocyst complex component Exo70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004140">
        <property type="entry name" value="Exo70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046364">
        <property type="entry name" value="Exo70_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12542:SF41">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12542">
        <property type="entry name" value="EXOCYST COMPLEX PROTEIN EXO70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03081">
        <property type="entry name" value="Exo70_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20669">
        <property type="entry name" value="Exo70_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst complex subunit Exo70 C-terminal" evidence="5">
        <location>
            <begin position="246"/>
            <end position="623"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU365026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDM37112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="626" mass="68795" checksum="7B31973EDD4D7584" modified="2014-04-16" version="1">MVAPRNTAYAEESAEVEVLYANLEKLNRLTKKIQGSMVRLETGGKVVKEAIGPIYSNTQSLQITNSNIDKVNDAIDRLRQPLDAKNREDGIIRAGPQSSGLTHYLGAMKRVEKALVDLNTTNLRSNQNAIADFNSLLNTGSTKLQEVLRGELSQHSTPVEPLHYLTKDLPFPSIPEDTVTHMAPLCSAVGSASVHGSQRGKGDNPALKAYAEVRGPYIASSLENLAIASLNTVKRRPTDGPYKQGTNGIGIYSNALEAFITTEHGIIVEMFTGDQQGLALQATFFPAMGEYSKTLRELNQYIKTNLMTDCFLAFEIIEIVTAMSYRIDSKAAELKSLLIEALRPVRETAKSSLSELLEETKRKAANTTLPPDGGSVPLVEEVMSSLATLTGYSGPLASILTSLGDGNWRAKSNTAGSAPLDVGPDSSTLLSHFILDMIEALMTSLEGRGRAFHRSKAALGVFLSNVFCVVDRSIRQSPELARYLGNPDSIARIDTFRKRATSTYLDAWKETSQYLLDVQYTSRGAQRNSSGNVDSSAIVKSLSSKDKDAIKDKFKAFNASFEDMVSRHKTLHMEREVRSLLTRELQTVLEPLYARFYDRYVEIDKGRGKYIKYDKASLSVQLAQLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>W6R708</accession>
    <name>W6R708_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Protein kinase gsk3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">gsk3</name>
        <name evidence="10" type="ORF">PROQFM164_S06g000589</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG792020">
        <property type="protein sequence ID" value="CDM37627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6R708"/>
    <dbReference type="STRING" id="1365484.W6R708"/>
    <dbReference type="OMA" id="MKTTMPM"/>
    <dbReference type="OrthoDB" id="272141at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004712">
        <property type="term" value="F:protein serine/threonine/tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14137">
        <property type="entry name" value="STKc_GSK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000055">
        <property type="entry name" value="Glycogen synthase kinase-3 beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000009">
        <property type="entry name" value="Glycogen synthase kinase-3 beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050591">
        <property type="entry name" value="GSK-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039192">
        <property type="entry name" value="STKc_GSK3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24057">
        <property type="entry name" value="GLYCOGEN SYNTHASE KINASE-3 ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24057:SF0">
        <property type="entry name" value="PROTEIN KINASE SHAGGY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="35"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDM37627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="394" mass="45053" checksum="7D1EE3CA30498828" modified="2014-04-16" version="1">MSQNRPGLFPTLRMGEVIREKVQDGLTGESKEISYTQCKIVGNGSFGVVFQTKMAPSGEDAAIKRVLQDKRFKNRELQIMRIVRHPNIVELKAFYYSNGDRKDEVYLNLVLEYVPETVYRASRYFNKLKTTMPMLEVKLYIYQLFRSLAYIHSQGICHRDIKPQNLLLDPATGILKLCDFGSAKILIENEPNVSYICSRYYRAPELIFGATNYTTKIDVWSTGCVMAELMLGQPLFPGESGIDQLVEIIKVLGTPTREQIRTMNPNYMEHKFPQIKPHPFNKVFRKAPPEAIDLISALLEYTPTQRLSAVEAMCHPFFDELRDPNTRLPDSRHHNNPPKDLPALFDFSQHELSIAPELNAQMIPPHARPALEARGLGLDTFKPLTKEEMLAHLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W6R742</accession>
    <name>W6R742_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S07g000010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Cyclase 1 superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG792021">
        <property type="protein sequence ID" value="CDM37662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6R742"/>
    <dbReference type="STRING" id="1365484.W6R742"/>
    <dbReference type="OMA" id="FWMTHTP"/>
    <dbReference type="OrthoDB" id="5396at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004061">
        <property type="term" value="F:arylformamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:L-tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.50">
        <property type="entry name" value="Putative cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007325">
        <property type="entry name" value="KFase/CYL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037175">
        <property type="entry name" value="KFase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34861">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34861:SF11">
        <property type="entry name" value="CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04199">
        <property type="entry name" value="Cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102198">
        <property type="entry name" value="Putative cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM37662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="316" mass="34676" checksum="B3AF6B79EC6444FC" modified="2014-04-16" version="1">MSPQRPSFDALPLRKDGPPGNAWGMFGDEDQMGMLNLLTPENTAAAAREIVDGVRVSTDWALNSMATPCFGRSSFEHIIKNKAPRIVNDDILTFNTQSSSQWDGFRHYGSKQGTYFNGCTQDDIQNSTLNGIHVWADNGGIVGRGVLLDYAGWAAANGKEVNCFETQSIPASVLQEVAASQNTTFRPGDILFIRTGWTRAYEQLSKAECQKLADYAAPPVIGVESSEATLRWIWDLGLAAVAGDMPSFEAYPCQNQVFSLHEWLLAGWGVPIGELFDLEQLSKECRKRDRWTFFFSSVPLKVPGGVASPPNGVAIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2024-10-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W6R791</accession>
    <name>W6R791_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transposable element</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S07g000060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792021">
        <property type="protein sequence ID" value="CDM37712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6R791"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004880173" description="Transposable element" evidence="1">
        <location>
            <begin position="21"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM37712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="105" mass="11781" checksum="B1775701E9DA1919" modified="2014-04-16" version="1">MASHFSSLVMLLWEFLGHLGEPAHVNAMVDHVEKPVSWKAASVAWPRRSSRCHSKRGRYQYGGHGRGAYDGVRIVTSRTWETATSGQSANISIERGNEIRGEYRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W6PRH2</accession>
    <name>W6PRH2_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10 13">Catalase</fullName>
            <ecNumber evidence="3 10 13">1.11.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">catA</name>
        <name evidence="16" type="ORF">PROQFM164_S01g000582</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the degradation of hydrogen peroxide (H(2)O(2)) generated by peroxisomal oxidases to water and oxygen, thereby protecting cells from the toxic effects of hydrogen peroxide.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 13">
            <text>2 H2O2 = O2 + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:20309"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="EC" id="1.11.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10 12">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 10 13">Belongs to the catalase family.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.6" evidence="3 10 13"/>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PRH2"/>
    <dbReference type="STRING" id="1365484.W6PRH2"/>
    <dbReference type="OMA" id="TTHMQQW"/>
    <dbReference type="OrthoDB" id="6880011at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004096">
        <property type="term" value="F:catalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070301">
        <property type="term" value="P:cellular response to hydrogen peroxide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03132">
        <property type="entry name" value="GATase1_catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.180.10:FF:000003">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1370.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.180.10">
        <property type="entry name" value="Catalase core domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018028">
        <property type="entry name" value="Catalase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024708">
        <property type="entry name" value="Catalase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024712">
        <property type="entry name" value="Catalase_clade2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043156">
        <property type="entry name" value="Catalase_clade2_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011614">
        <property type="entry name" value="Catalase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002226">
        <property type="entry name" value="Catalase_haem_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010582">
        <property type="entry name" value="Catalase_immune_responsive"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041399">
        <property type="entry name" value="Catalase_large_C"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF00199">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038927">
        <property type="entry name" value="Catalase_clade2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00067">
        <property type="entry name" value="CATALASE"/>
    </dbReference>
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        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Heme-dependent catalase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00437">
        <property type="entry name" value="CATALASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00438">
        <property type="entry name" value="CATALASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51402">
        <property type="entry name" value="CATALASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10 13" id="KW-0349">Heme</keyword>
    <keyword evidence="9 10 13" id="KW-0376">Hydrogen peroxide</keyword>
    <keyword evidence="8 10 12" id="KW-0408">Iron</keyword>
    <keyword evidence="6 10 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 10 13" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Catalase core" evidence="15">
        <location>
            <begin position="31"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="154"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="12">
        <location>
            <position position="368"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
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            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00005329"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00012314"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004142"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM01060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CDM26773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="725" mass="81549" checksum="C030EA08B9377FCA" modified="2014-04-16" version="1">MAAKSHSKTADGKFADLQKDTIEVNDKQHMTTDNGVKISNPDQWLRIVDEKNLGPSLLEDQIAREKITRFDHERIPERVVHARGSGAFGTFKLFESAEDVTTAGILTDTKRETPLFVRFSTVQGSRGSADTVRDVRGFAVKMYTAEGNWDIVGNNIPVFFIQDSIKFPDVIHSVKPEPHNEVPQGQSAHNNFWDFQYLHSEATHMNQWIMSDRAIPRSLRMMQGFGVNTYSLINKAGKRHFVKFHFTPELGVHSLVWDEALKIGGQDPDFHRKDLMEAIEAGHFPRWKFGLQLIPEEKADSFEFDPLDATKVWPEELVPIRYIGEMELNRNIDEFFPQTEQVAFCTSHIVPGIDFSDDPLLQGRNFSYFDTQISRLGPNWEELPINRPVCPYMNLVNRDGQGRHRITKSKVNYWPNRFSANPPATAEQGGFVSYPAKPQGAKKRALSEKFKEHFNQPQVFYNSLSPIEKMHVAKAFSFELDHCDDPVVYKRMSERLTAIDLDLAKTVAKNVGGDAPVKASKENRGIKAKGLSQLEFMPEKPIIATRRIAILIADGFDFNQYTTMKEVLKERGAFVITVGTQRQGVTAESGQKVIPDHFYSGMRSTLFDAVYVPGGKHIQALSKNGVFKHWISESFAHLKAIAGANEAVPFIERQIGLSEVEVAKSGSPLKESYGVVTGHGDAVSLLKVGTVAPDSKGLAEQFIWHVSQHRNWARELDGLSDQIAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W6PRT8</accession>
    <name>W6PRT8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S01g000722</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PRT8"/>
    <dbReference type="STRING" id="1365484.W6PRT8"/>
    <dbReference type="OrthoDB" id="17560at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM26913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="91" mass="9965" checksum="ADA2F8A113949FDB" modified="2014-04-16" version="1">MTTSRSRRGIFGRPGTADNLDPVIAPGLNIFSIFLAPKCHESEDILAKTGQPYQINLFGGVEHEFAVCADITKLTIRFAKQSDFFVGSCMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W6PRU4</accession>
    <name>W6PRU4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Zn(2)-C6 fungal-type DNA-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PROQFM164_S01g000285</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PRU4"/>
    <dbReference type="OMA" id="QSAFTEC"/>
    <dbReference type="OrthoDB" id="10261408at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF5">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="41"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="161"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="185"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM26476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="235" mass="26498" checksum="B47482ED3BF42C7A" modified="2014-04-16" version="1">MGSAVYRCVYPTPLIPLDLPQEENKMASKSKEKRPARITTACNSCRSRKQKCSGLKPVCEQCLENNRPCNWPEQLRRGPEKGYTEALENRLQLTESILLNLLPHVSDEQLSAAIPPRESSRGHAAGTYVPFPRLEKGGIDTWSQFPLDTSHGIRRWQKACTEPEMVGSEKKKRSQNDRLHGSVPISPTTRKVDGTSSETPNHPVPGSSHKESAPVERLSSWQEAPSFEFQRHFLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W6PRW7</accession>
    <name>W6PRW7_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g000762</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PRW7"/>
    <dbReference type="OMA" id="LMYDGNT"/>
    <dbReference type="OrthoDB" id="4272375at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="242"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM26953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="443" mass="50960" checksum="02EDF7D10E4E5355" modified="2014-04-16" version="1">MEPTKFPKRPTVRWDPYKRQVLCCLYRFFTCNKKQTAEIFSYMFRSHLKQRGIQGFVPFATLNTQWIWMRNKRDPVWLRVHINTAFETSGEWGEIITKIKSAAKTLRFELHEKMEDDTHPSRCGPLVPDAEQNIASHGPAVPMLSQSLFTAETLNPIPLLSPSQDQAFEGRYRANQSADQSIDQSIGPQNDLHIDIPNRPHRSTEPVVTSNGKLCLWCEHEGTIHESEDIQELQNEDYDYDSEYEEHSDGNQHNDRQDDPGMTDYIQGCKQFVRELRGEELFDSESEPYLLKPHKSLSRMHSFCDPHLPLPLNLEQGSLDSEDNSDWCADRGIPANLADFGSLSIAMKNRSGALGNERTSTQKSSRSFSFSHTCTDHDEALGDRLGGQNALQYEWPSNDRMRMETLRQMSVEALRQVEDQSTTHLSQEEIDVLMYDGNTWKQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W6PSM3</accession>
    <name>W6PSM3_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Tyrosine-protein kinase, catalytic domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PROQFM164_S01g000659</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PSM3"/>
    <dbReference type="STRING" id="1365484.W6PSM3"/>
    <dbReference type="OMA" id="QPYQDPL"/>
    <dbReference type="OrthoDB" id="9332038at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004713">
        <property type="term" value="F:protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14212">
        <property type="entry name" value="PKc_YAK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000087">
        <property type="entry name" value="Dual specificity tyrosine-phosphorylation-regulated kinase 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000380">
        <property type="entry name" value="Serine/threonine-protein kinase ppk15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050494">
        <property type="entry name" value="Ser_Thr_dual-spec_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058:SF17">
        <property type="entry name" value="HOMEODOMAIN INTERACTING PROTEIN KINASE, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="344"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="687"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="18"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="49"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="111"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="142"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="703"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="736"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="791"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="803"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="373"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDM26850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="890" mass="99232" checksum="EA28E102B83F8C00" modified="2014-04-16" version="1">MDPGWQPYQDPLMGHPAQFNTALASHPQQLASKYGQPPQSQPPVGYTYETFQTPVTTSKAPSAGSNSKTVSMASSPTATPRTRDYVTDADTTMEDADPYNRAKYPSRPNHNRASSQFLNQAEESSAARRYSPGNVLSPPMSYPTSPGKSQGSYGFPSAPQNASRRSPARPEYASPPQGYQSPPSNRPPRLPPLQSGDLSPDQYYPPSASSHMSPGFGPGARSPRSGSLPSQAPLVPGRGPVPKFQKIQSVQELKPRMNIQPAYRRANPEGGFISPLQSLTTHLPATYRICNPGFNYESSRNPRRVLTKPSKGVKNDGYDNEDSDYILYVNDILGSEEAGHKNRYLILDVLGQGTFGQVVKCQNLKSGEVVAVKVIKNKTAYFNQSMMEVSVLDLLNSKYDKNDDHHLLRLKDTFIHRQHLCLAFELLSVNLYELIKQNQFRGLSTTLVRVFAQQLLNALSLLNKAHLIHCDLKPENILLKNLESPIIKVIDFGSACDERQTVYTYIQSRFYRSPEVLLGLPYSSAIDMWSLGCIVVELFLGLPLFPGSSEYNQVCRIVEMMGIPPTWMLEMGKQSGEFFEKTQDEFGRKTYRLKSLEQYSREHNTKEQPSKKYFSASTLEEIIRSYPMPRKNMKQAEVDRELNNRIAFIDFVRGLLSINPLERWSPQQAKLHPFITQQKFTGPFMPPMNLKYSTATKPAPGVQQQQQAEAASKQRAAQAAHAQNAYAVQMNQFHTPPQPQPQPQPQAPPMYNGMYPQGAPPPPYPTQQSPGYGHQMGMMPGNQVPPQSLYAQATTRAGRQRASTMDPNGGIPTTIQRVASHLDPNAPIRLQPSPAYYPPPPDGYVDANASQRRRGSRAGNANGNQRNRDFIRTLEDGVLSEGYMGQNQWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W6PT01</accession>
    <name>W6PT01_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S01g001117</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PT01"/>
    <dbReference type="STRING" id="1365484.W6PT01"/>
    <dbReference type="OMA" id="TRNAGFY"/>
    <dbReference type="OrthoDB" id="4327079at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM27308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="193" mass="20529" checksum="687DAF7F93344320" modified="2014-04-16" version="1">MVSTDSIIVVGAGACGLSVALHLSLRGYTNVSVFAEDDYIPFGDLTNVYRAAQIAGVRFFLGQQIDQIVYVSTLTGKKSAGIRMRNAGFHPSSLIIVETGARDGDSSEIGQLHPDPLAIPLSCYTNTDPNFVVEYVPEVSSSVILLSKNLVQTSKMSLVGPLVVDLLETTGGQQTAVQVQKESGTSLQPLSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W6PUK9</accession>
    <name>W6PUK9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transcription factor, MADS-box</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PROQFM164_S01g001386</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PUK9"/>
    <dbReference type="STRING" id="1365484.W6PUK9"/>
    <dbReference type="OrthoDB" id="1898716at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1810.10">
        <property type="entry name" value="Transcription factor, MADS-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002100">
        <property type="entry name" value="TF_MADSbox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036879">
        <property type="entry name" value="TF_MADSbox_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00319">
        <property type="entry name" value="SRF-TF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55455">
        <property type="entry name" value="SRF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="MADS-box" evidence="7">
        <location>
            <begin position="23"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM27575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="153" mass="17645" checksum="D797EAEC217DDC88" modified="2014-04-16" version="1">MAALKTTRSKNSSTRKLMHQKQYRRKANMLKKASEYSKMCDADVCVGIRMRETGQVHILSADSSGFWAFLISQLSSYYPTPTVMTDRDLEKTREETVSREQRETGQVHILSADSSGFWAFLISQLSSYYPTPTVMTDRDLEKTREETVSREQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W6PUN2</accession>
    <name>W6PUN2_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PROQFM164_S01g001739</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PUN2"/>
    <dbReference type="STRING" id="1365484.W6PUN2"/>
    <dbReference type="OMA" id="TCIFNQA"/>
    <dbReference type="OrthoDB" id="5226580at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF37">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="74"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM27928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="575" mass="65631" checksum="3760E6B735B1CA8A" modified="2014-04-16" version="1">MTPVSKTCQRCADSKVRCVRDTNIAACIRCRRLEKEGVHRRTGRRFNGFHKDRKIAALESKINELKADRAGPKNNNSTSTRNTSLADGDAPEEIINRHFLDVDTAERYLSTFKTKLTPHFPFVVVPPDVSFKQLRQEKPFLCLAILASASYENMPLQRALGDEVKKVVASRMVIGGEISFELLQGLLVFLAWLHYYSRPHRYTQFLQLAISIMIDLRLDRPPQTRTWKTELRFGLQYNLQDRTFNRPSWGSNEQRAVLGCYYLSSSIAMLVQKKSTILRLPYQEECCKTLREANEYPHDKYVSYVIQLQFIAEKVDNLSAKHGFDLETPGSGSELYISNLKSDLDAFYRHLPFDINDSFLLAIQYHATGLGLYQLALNITNRDPQPQFDSDSWKDDMSFSALISASSILNLYIELPSNEEVGFNNTQWVQIAFALLVTYRHTVAASKPDQTAAFLQTLSKLKSRVGALSTSDVDMKGARDAFFDFKNRIVQIENWLQGHDRQEDNSPSEENFEEFQHTLCVESEPTHFDGFTEAVETEDLDVTLWNLFSSSASGLQMPHDFLFASSSEQIVGDWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W6PUQ6</accession>
    <name>W6PUQ6_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alanyl-tRNA synthetase, class IIc</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g001312</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PUQ6"/>
    <dbReference type="STRING" id="1365484.W6PUQ6"/>
    <dbReference type="OrthoDB" id="4524175at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004812">
        <property type="term" value="F:aminoacyl-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003156">
        <property type="entry name" value="DHHA1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02272">
        <property type="entry name" value="DHHA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHHA1" evidence="1">
        <location>
            <begin position="64"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM27501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="173" mass="18498" checksum="50D6B1D175AEB97B" modified="2014-04-16" version="1">MMWLSIGKVPSAISILDKKLFARRLEGSIKEMMKEQKETQRSQVDAAINHVKTVIDDNPASTSFVVNLPTDCSAKVITEAIKHVSSIHDNKSVYFIGVGATGRVAQGCFVSPKHTSNRLVANEWAAQVAKVVGGKAGGKAGGKGLTSMGSGPDKAKVEDGMVAARMYLQELRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>W6PWE9</accession>
    <name>W6PWE9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S01g002399</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PWE9"/>
    <dbReference type="OrthoDB" id="5228066at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM28588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="80" mass="8831" checksum="84AB92D7866B508D" modified="2014-04-16" version="1">MINTIDAPDNAMAIIVDISAPGGKFVIGRHAPTPWGNDVVAERATEGKTHLVIWPWQPEWQFYAIGSTKIRYLVKPSNAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W6PWG9</accession>
    <name>W6PWG9_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Mannosyltransferase</fullName>
            <ecNumber evidence="11">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">smp3</name>
        <name evidence="13" type="ORF">PROQFM164_S01g001962</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM164</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Endoplasmic reticulum membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the glycosyltransferase 22 family. PIGZ subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="11"/>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PWG9"/>
    <dbReference type="STRING" id="1365484.W6PWG9"/>
    <dbReference type="OMA" id="HGIHPRY"/>
    <dbReference type="OrthoDB" id="10066429at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005599">
        <property type="entry name" value="GPI_mannosylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760:SF3">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03901">
        <property type="entry name" value="Glyco_transf_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 11 13" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="5 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004879796" description="Mannosyltransferase" evidence="12">
        <location>
            <begin position="18"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="169"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="275"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="345"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDM28151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="535" mass="60971" checksum="0A93EECADABECEFD" modified="2014-04-16" version="1">MWRRTYLLLLVIRVYFALSPSYLHPDENFQGPELFAGRIFSFPSKIPWEFTVEHPIRSIFPIWAAYELPMNLLKWFYTETGEGSPPPHMIYNALRGGMFLLSFVLEDWAIYELVPSPRHRRATVVLVASSYVTWTYQTHTFSNSLETLLVAWGLVLIRRIVNNKRHSSFFSHAVLAFIAVVGVFNRITFPAFLLFPGLQLLPQFQRKPLGLAAFLLFGLFFSFIAIYTDTIFYRPTASFLSVFRHPIITPLNNLLYNTDTANLAQHGLHPHYQHFTANLLQLLGPAYIAMIVSLFSRPLIPYWMRNVRALSALSATMLLSLFPHQEPRFLLPVVPLLLSCFPMRGSRLLVVVWVIFNAAMGFLMGVYHQGGVVPTQLAMRDIVSSSPTPYIPSATVFWWKTYSPPLWLLGGDDQSTEIQTLDLMGMSGVDMIQQLELVVPGCSTPSPVFLVAPTSATFLDQYVFSAPQSQDQDQDQDQDQAQAQNQTLQLHQLWSYRNHLNLDDMDFGDDGILPTLKRVVGRRGLDVWSVQRSCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2024-10-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>W6PWS0</accession>
    <name>W6PWS0_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S01g002514</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PWS0"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM28703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="73" mass="7979" checksum="63F458FFFFE0AAED" modified="2014-04-16" version="1">MTPEGSLSNHCNTTSLVHHMTFAGRISEIHGGCPPHSTTQSTRPAQYFLRLSTCEVQTGHSYFETAAKVMPMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W6PX70</accession>
    <name>W6PX70_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">V-type proton ATPase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">vma-6</name>
        <name evidence="8" type="ORF">PROQFM164_S01g002187</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7">Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments. This subunit is a non-integral membrane component of the membrane pore domain and is required for proper assembly of the V0 sector. Might be involved in the regulated assembly of V1 subunits onto the membrane sector or alternatively may prevent the passage of protons through V0 pores.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d, e, f and VOA1).</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the V-ATPase V0D/AC39 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PX70"/>
    <dbReference type="STRING" id="1365484.W6PX70"/>
    <dbReference type="OMA" id="MTYGYMI"/>
    <dbReference type="OrthoDB" id="10250083at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033179">
        <property type="term" value="C:proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1690.10:FF:000001">
        <property type="entry name" value="V-type proton ATPase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1690.10:FF:000003">
        <property type="entry name" value="V-type proton ATPase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.50">
        <property type="entry name" value="ATP synthase (C/AC39) subunit, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1690.10">
        <property type="entry name" value="V-type ATP synthase subunit C domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036079">
        <property type="entry name" value="ATPase_csu/dsu_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002843">
        <property type="entry name" value="ATPase_V0-cplx_csu/dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016727">
        <property type="entry name" value="ATPase_V0-cplx_dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035067">
        <property type="entry name" value="V-type_ATPase_csu/dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044911">
        <property type="entry name" value="V-type_ATPase_csu/dsu_dom_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11028">
        <property type="entry name" value="VACUOLAR ATP SYNTHASE SUBUNIT AC39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01992">
        <property type="entry name" value="vATP-synt_AC39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018497">
        <property type="entry name" value="V-ATP_synth_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103486">
        <property type="entry name" value="V-type ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4 7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00059115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR018497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM28376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="364" mass="40778" checksum="0D7D19368466582D" modified="2014-04-16" version="1">MEGLFFNINGGYVEGIVRGYRNSLLTGQNYSNLIQCETIDDVKLQLAPSYGDVLASLSPNPSTSDLASRMTDKLVAEFKYLVAQATGSSAKFLEYMTYGYMIDNIALLITGTLHERDTRELLERCHPLGWFETLPVLCVATNIEELYNSVLIETPLAAYFKGSLSHQDLDELNIEIVRNTLYKNYLEDFYNFINTHPDFSGTPTQDVMAEILQFEADRRAINITLNSFGTELSKLERRKLYPEFGKLYPEGSLMLSRAEDVEGVALAVSAVADYKAFFDAVGMSQGGGGLGGMGGGPADGKSLEDLFYQKEMDMSKLVFTRQFTPAVVYAWMKLKEQEIRNITWIAECIAQNQKERIGNFISVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W6PXH5</accession>
    <name>W6PXH5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Nucleotide-binding, alpha-beta plait</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PROQFM164_S01g002297</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HTATSF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PXH5"/>
    <dbReference type="STRING" id="1365484.W6PXH5"/>
    <dbReference type="OMA" id="DTDFRFG"/>
    <dbReference type="OrthoDB" id="10258585at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12281">
        <property type="entry name" value="RRM1_TatSF1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12285">
        <property type="entry name" value="RRM3_RBM39_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000105">
        <property type="entry name" value="HIV Tat-specific factor 1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034393">
        <property type="entry name" value="TatSF1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034392">
        <property type="entry name" value="TatSF1-like_RRM1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15608:SF0">
        <property type="entry name" value="HIV TAT-SPECIFIC FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15608">
        <property type="entry name" value="SPLICING FACTOR U2AF-ASSOCIATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="97"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="243"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="55"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="331"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="198"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="368"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM28486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="423" mass="48665" checksum="3251404706477740" modified="2014-04-16" version="1">MSFPTDVAEFDSDPRISFSRPDNSFLLETKDGREFLFNTILKRWVESIDEKLIRQQQGYGPEDPESEIVHPRDRKKRKQSQEPTDEPKVKKPRVNTAVWVTNIPTDATFSEIHESFKKYGILAEELDTGKPRIVMYNDENGNFNGEALVVYFRPESVTLAIQLLDETDFRLGVPNPCGLMRVQEADFSYKREQEAEPKVLTTKEKKKLKERADRLNKKLSDWGDDEAELAAKARQAAEEARKHVVLKHMFTLEELEEDPLATIEIHEDITSECAKIGPVLKVMVWDGEADGVATVRFVSAADARRCAQSMDGRIFSKRTIVAYIWNGEEKFKKHRPRRDKKPEDSDDENERLERYGDWLESGGNKTSKNQETENEKADKDETDKSQETNNEKADKNEADKSLETGNEKVDLDETDKSQEIDKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W6PXL1</accession>
    <name>W6PXL1_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Beta-lactamase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S01g002774</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PXL1"/>
    <dbReference type="STRING" id="1365484.W6PXL1"/>
    <dbReference type="OMA" id="GHTPDHG"/>
    <dbReference type="OrthoDB" id="449487at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050313">
        <property type="term" value="F:sulfur dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070813">
        <property type="term" value="P:hydrogen sulfide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07724">
        <property type="entry name" value="POD-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051682">
        <property type="entry name" value="Mito_Persulfide_Diox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044528">
        <property type="entry name" value="POD-like_MBL-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43084">
        <property type="entry name" value="PERSULFIDE DIOXYGENASE ETHE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43084:SF1">
        <property type="entry name" value="PERSULFIDE DIOXYGENASE ETHE1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="2">
        <location>
            <begin position="18"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM28963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="307" mass="34921" checksum="C3A9B0E260BCDABE" modified="2014-04-16" version="1">MANTVEPRVHPFFEPKTCSWQYLVACPETKEAAIIDPVLDYDTVNFAITSESADQIIDYAMKNEYTIMMLLETHAHADHLSAAYYIQQILWSRGEPHAPICIGENVKIVQSFFARKYAIAKADIDNAFDHLFQPDEIFQIGQVTSSALHLPGHTPDHGGYKFGSNIFTGDCMFNPDVGSGRCDFPGGDPRELYRSMKRLLSFPPETRLYTGHDYPPTNEYTAREPLPYVTVGEQEKKNKHMKKHTTEDEFVKWRTQRDSQMPEPKLVHQAMQVNVRGGKMPSKSHNGKAYLLYLLDVPKVLVPGVQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>W6PXS3</accession>
    <name>W6PXS3_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Guanine nucleotide-binding protein subunit alpha</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">fadA</name>
        <name evidence="9" type="ORF">PROQFM164_S01g002402</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the G-alpha family. G(q) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PXS3"/>
    <dbReference type="STRING" id="1365484.W6PXS3"/>
    <dbReference type="OMA" id="QVIWADA"/>
    <dbReference type="OrthoDB" id="5817230at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031683">
        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000750">
        <property type="term" value="P:pheromone-dependent signal transduction involved in conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00066">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.400.10:FF:000001">
        <property type="entry name" value="Guanine nucleotide-binding protein G(I) subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000051">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000692">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.400.10">
        <property type="entry name" value="GI Alpha 1, domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002975">
        <property type="entry name" value="Fungi_Gprotein_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001019">
        <property type="entry name" value="Gprotein_alpha_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011025">
        <property type="entry name" value="GproteinA_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218">
        <property type="entry name" value="GTP-BINDING PROTEIN ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218:SF302">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN ALPHA-5 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00503">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00318">
        <property type="entry name" value="GPROTEINA"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01241">
        <property type="entry name" value="GPROTEINAFNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00275">
        <property type="entry name" value="G_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47895">
        <property type="entry name" value="Transducin (alpha subunit), insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51882">
        <property type="entry name" value="G_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0807">Transducer</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="43"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="150"/>
            <end position="151"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="175"/>
            <end position="181"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="200"/>
            <end position="204"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="269"/>
            <end position="272"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="325"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM28591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="353" mass="40880" checksum="6034086AAE5A311F" modified="2014-04-16" version="1">MGCGMSTEDKEGKARNEEIENQLKRDKMMQRNEIKMLLLGAGESGKSTILKQMKLIHEGGYSRDERESFKEIIYSNTVQSMRVILEAMESLELPLEDARHEYHVQTIFMQPAQIEGDSIPPEVGNAIGQLWRDTGVQECFKRSREYQLNDSAKYYFDSIERIAQPDYLPTDQDVLRSRVKTTGITETTFIIGDLTYRMFDVGGQRSERKKWIHCFENVTTILFLVAISEYDQLLFEDETVNRMQEALTLFDSICNSRWFVKTSIILFLNKIDRFKEKLPVSPMKNYFPDYEGGADYAAACDYILNRFVSLNQAEQKQIYTHFTCATDTTQIRFVMAAVNDIIIQENLRLCGLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>W6PXY6</accession>
    <name>W6PXY6_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Zn(2)-C6 fungal-type DNA-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PROQFM164_S01g002924</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PXY6"/>
    <dbReference type="OMA" id="FPLCLHY"/>
    <dbReference type="OrthoDB" id="4337792at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051430">
        <property type="entry name" value="Fungal_TF_Env_Response"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31944:SF129">
        <property type="entry name" value="ASPYRIDONES CLUSTER REGULATOR APDR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31944">
        <property type="entry name" value="HEME-RESPONSIVE ZINC FINGER TRANSCRIPTION FACTOR HAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="21"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="63"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM29113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="687" mass="77693" checksum="A537E029F7E775BB" modified="2014-04-16" version="1">MQLSTKSPESGIRKRRRPAHSCVECRRRKVRCDRANPCSQCVAHNAPSCTFTDNRRITSDHNLRESQATKQQEHRTSIIPDGSPSSNISPPTPAPSGRIHGTQSKTRVFGQGHWMSTKRLATELSILGPVMAYQTTLFQQPIDANRGLMSQKMAKCKELAREIKKQRPNRQSLPAEIHRSFPERQVIDDLVQLYFATFESCYRILHRSSFQADYERYIDHPESAKSSFVVELLLIISAAGPLHSHGETRRELAEKSISWINIAQTWLSAPLEKDRLTLKGIQIYCLLLLSRQVNRIGADLVWVSAGSLMRMAMQMGLHQDPNYLGDMDFRQKEIRRRLWYTILEMNLQAALDSGMAPMITESDYNTMPPSGIEDADLDSAVSEDRETIATSSTRQPLLCVLASSFSLRLRATRVINSLQEEPSYHLVLDLGNELASICRKAAVEISHNLSEEHISLGSQFAYSFCSHLLNRFLLCLHFNYAIQATRNPLYAHSHKVCLEVALDLISLLDYDLYSRLLVNGGGMFRDIITRGALMIYLELHKSHESDISILAKRRNRARQEPLLKDAHRVVRYAKDRMCQGETNVKGYLFLRIATARAEAMLDGLPVEQAMENAALESLNDCETILGNMSTDLSNNGGDSDAEAWRHEEIMCTPTAFDVGLGFLDDDNFSFDHLDPSIFQNLTDPSFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W6PYC7</accession>
    <name>W6PYC7_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">glucose oxidase</fullName>
            <ecNumber evidence="14">1.1.3.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">PROQFM164_S01g003070</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>beta-D-glucose + O2 = D-glucono-1,5-lactone + H2O2</text>
            <dbReference type="Rhea" id="RHEA:11428"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15903"/>
            <dbReference type="ChEBI" id="CHEBI:16217"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="EC" id="1.1.3.4"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:11429"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 16">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Cell wall</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Secreted</location>
            <location evidence="4">Extracellular space</location>
            <location evidence="4">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 17">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.3.4" evidence="14"/>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PYC7"/>
    <dbReference type="STRING" id="1365484.W6PYC7"/>
    <dbReference type="OMA" id="LQDQMNN"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046562">
        <property type="term" value="F:beta-D-glucose oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.450.10">
        <property type="entry name" value="Glucose Oxidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027424">
        <property type="entry name" value="Glucose_Oxidase_domain_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF201">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE OXIDOREDUCTASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00623">
        <property type="entry name" value="GMC_OXRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0134">Cell wall</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="11 16 17" id="KW-0274">FAD</keyword>
    <keyword evidence="10 17" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0964">Secreted</keyword>
    <keyword evidence="18" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012587799" description="glucose oxidase" evidence="18">
        <location>
            <begin position="16"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="19">
        <location>
            <begin position="104"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="20">
        <location>
            <begin position="299"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="15">
        <location>
            <position position="529"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="15">
        <location>
            <position position="572"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="36"/>
            <end position="37"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS00623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="CDM29258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="592" mass="64035" checksum="6FD858715D95129D" modified="2014-04-16" version="1">MRSLIGLALLPLAVAVPHTSQKSESTYDYIIVGGGTSGLVVANRLSEKKDTTVLVIEAGGSVYNNLNVTDTLGYGKAFDTDIDWAYKTIDQEYAGGSPQTIRAGKALGGTSTINGMAYLRAQAAQIDAWETVGNKGWNWKTLLPYFKKGEHLQDPAQYPFLDGSGVAFDPAYHGFTGPLKVGWSSTQLNDGLAQKLNTTYQNLDVPVQYNLDPNGGDMVGYSLYPKTVDSELNIREDAARAYYYPYQNRNNLLVWLNTHANKITWKNGHEVTANGVEVTFSNGTTTVVKATREVILAAGALKSPVLLELSGIGNPNILSKYGIATKINLPTVGENLQDQMNNGLQFDSKKTYSSNKSADYVAYPSAAQLFPNSTALGAELLRELPAYAAQVASANGNITKARDIYRFFKIQWDLIFKSGIPVAEILLSASGTSYSSEYWGSVPFSRGSVHLSSADPTAAAIIDPKYFMLDFDLHSQVEAARFIREIFKTEPFADMVGAETSPGLSTVAAGAEDEGWADFIKGQYRSNFHPITTAAMLPKEIGGVVDSSLKVYGTSNVRVVDASVMPFQVCGHLQSTVYAVAERAADIIKACS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W6PZ11</accession>
    <name>W6PZ11_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Oxoglutarate/iron-dependent dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S01g001003</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PZ11"/>
    <dbReference type="STRING" id="1365484.W6PZ11"/>
    <dbReference type="OMA" id="KWYPELY"/>
    <dbReference type="OrthoDB" id="627829at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044283">
        <property type="term" value="P:small molecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.330:FF:000057">
        <property type="entry name" value="Oxidoreductase, 2OG-Fe(II) oxygenase family, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="3">
        <location>
            <begin position="170"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM27194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="348" mass="38958" checksum="8DC52CAE74F1DB5D" modified="2014-04-16" version="1">MTETFSSVPIVDFARLNDPSTKDEELSNLRQAIFVVGFLYLTNTGLESLIKRTHENLPKLFALSAEAKEKCNMINSPSFLGYTRLGAETTAKQTDLREQFDFGTPGVRPWTEQDPFWQRLEGPNQYPDYPGVQDLVEEYIAKTDSLAQAFVRLVAECLSLPRETFDGFKGNMSRLKFVKYPPAVQSSQGVGPHKDSAGLFTFLSQDNTGGLQVLNKNGEWINVPPIEGSLVVNIQQGFEAITGGICAATTHRVIAPTSQTRYSIPFFQGVRLDLTLNQLKESAAHIVQRIPASDDKKKRAVDVPSEFLSPLYSCFGEAHLRNRILSHPDVGQRWYSELYAKYSQQVLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W6PZ49</accession>
    <name>W6PZ49_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Nitrogen regulatory protein areA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">AREA</name>
        <name evidence="14" type="ORF">PROQFM164_S01g001043</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PZ49"/>
    <dbReference type="STRING" id="1365484.W6PZ49"/>
    <dbReference type="OMA" id="WRMMAMS"/>
    <dbReference type="OrthoDB" id="515401at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042128">
        <property type="term" value="P:nitrate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000007">
        <property type="entry name" value="Nitrogen regulatory AreA, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013860">
        <property type="entry name" value="AreA_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011420">
        <property type="entry name" value="AreA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039355">
        <property type="entry name" value="Transcription_factor_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071:SF281">
        <property type="entry name" value="BOX A-BINDING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071">
        <property type="entry name" value="TRANSCRIPTION FACTOR GATA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07573">
        <property type="entry name" value="AreA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08550">
        <property type="entry name" value="GATA_AreA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00619">
        <property type="entry name" value="GATAZNFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00344">
        <property type="entry name" value="GATA_ZN_FINGER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0534">Nitrate assimilation</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GATA-type" evidence="13">
        <location>
            <begin position="654"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="116"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="559"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="612"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="706"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="122"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="174"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="577"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="710"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="732"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="747"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="766"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="813"/>
            <end position="839"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDM27234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="860" mass="91625" checksum="7CBED38BB5E16C17" modified="2014-04-16" version="1">MDGIHHGGHGRARPSHPMAFPDFDADSHMMSDDFSFDTPFSPSGSSNANDTVLGNSIFPEWTNGASRGDSPDEMQRKDPLGAQIWKLYTRTKSQLPNQERMENLTWRMMAMNLKRKEREQQARASETLSPTPSGIAQMRLSDQPSPAGGDLAHDTTSDPMNLDDFIVPFDSPAEHSSHPIDRHFTATPTGSIPIKSRKDHAMMDSSTAASFPHPPQDQRTNSEFGYVARRVRKTSVDDRQFFAGLSVPTRKRPAEASPQVPPVSNAMMAQHSELSSALPDYSLDHPPSAYALSGNGTVGPRRPQHHHTHSNIPYGLDTYGISEDHGLNSAGSYQQNFHFSPSDSPMTAGNPFSSLYAQTPLASSLNSTEFFSPPPSGYQSTVSTPQPIYEGEQSIFFSDAPSAESHTQRRIPNYIQQRQSNLSASLQPRYMYNMSNGESHSGSAVTGPPTTHVSGFSVPPPQHINPSQVLGHGEFSTTAPSSSMFTFGGDSDNEDDDGNFGEGGGMTMPNDFASLDESGDMSAGLHWDGGFPGSIHSLPGFNAQHRKHVTIGSTDMIDGPPEWNQGGTLGRAHGSAASVSEVRNQNQDPRRYGKVPRTASTPNAAALLRQSLNGSASGPPTNHPSPSTPPESGLSSAVPSRPGSPGGSKNGDPNAGPTTCTNCFTQTTPLWRRNPEGQPLCNACGLFLKLHGVVRPLSLKTDVIKKRNRSSASTLAVGTSRSSKKSSRKNSIQHAPSTSISSRMNTSESPPSMNGSSSLGKTGVVPIAAAPPKSGPPAGVAQARAGVQVAPRRQRRLEKAPTGSDPDLEDSPKSAAPPSRSKVVPLAPAMAPPAAANPANHSIAGGQGASQEWEWLTMSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q045</accession>
    <name>W6Q045_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cupredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PROQFM164_S01g003467</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the multicopper oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q045"/>
    <dbReference type="STRING" id="1365484.W6Q045"/>
    <dbReference type="OMA" id="QTHMANG"/>
    <dbReference type="OrthoDB" id="2121828at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF488">
        <property type="entry name" value="LACCASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Plastocyanin-like" evidence="5">
        <location>
            <begin position="7"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDM29655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="128" mass="14354" checksum="5D49885F4785276C" modified="2014-04-16" version="1">MPNSPAIQAPHVMHKHSNKGFILSFSPGIFNWFSTEEAYAECPELFQLENPQMRDTFVTNGPNGPTWMIVRYQVVNPGPFISHCHIQTHMANGMAVALLDGIDVWPQSVRTRSLQPQTIGLVVEALLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q0A8</accession>
    <name>W6Q0A8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PROQFM164_S02g000102</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM29953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q0A8"/>
    <dbReference type="STRING" id="1365484.W6Q0A8"/>
    <dbReference type="OMA" id="YCRIFPT"/>
    <dbReference type="OrthoDB" id="10017208at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="79"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="205"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="31"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="296"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM29953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="350" mass="39018" checksum="7D64ECC668F555C9" modified="2014-04-16" version="1">MAAYNAQDSYQGSYRAGTITMTVLGVLFVILRFLARWKKSLKPGLDDFFIVLALFPLLALVGLMLSLTNYGMGLHSQVLPLANIIMIAKLLLIFEIMYVTTVATTKISILLMYCRIFPTREIRIASLVLGGMTLSWLVAIILVSVFQCNPIPRAWDTRIPGKCINLKGMFIGNAVPNILTDILILSLPVKVVWGLHASLTHRLSVIGIFLLGSFVVFTSAYRFATIFGFDPTDIAWTLGRSCTWCVVESSTGIISACMPTLRPLFMIFSSKFSSRSGTRSRTTDLDQSKGYELDNSALRPANEPRNKTRTQLEVSHADDGSEDEVPLNSIRVQQYMTWQESRGDSFRGYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q0M0</accession>
    <name>W6Q0M0_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S02g000242</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q0M0"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM30093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="53" mass="6411" checksum="E9B72B7E0ECD5F69" modified="2014-04-16" version="1">MYSGLYKKHKRHTTYLMHDLLATYKYAPNGYLSAFLSFLCFISFHFSFKFRFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q0Y1</accession>
    <name>W6Q0Y1_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Putative gamma-glutamylcyclotransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PROQFM164_S01g003438</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the gamma-glutamylcyclotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q0Y1"/>
    <dbReference type="OMA" id="DPEPWQK"/>
    <dbReference type="OrthoDB" id="1044435at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06661">
        <property type="entry name" value="GGCT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.10">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045038">
        <property type="entry name" value="AIG2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009288">
        <property type="entry name" value="AIG2-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013024">
        <property type="entry name" value="GGCT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036568">
        <property type="entry name" value="GGCT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31544">
        <property type="entry name" value="AIG2-LIKE PROTEIN D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31544:SF2">
        <property type="entry name" value="AIG2-LIKE PROTEIN D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06094">
        <property type="entry name" value="GGACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110857">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Gamma-glutamylcyclotransferase AIG2-like" evidence="4">
        <location>
            <begin position="6"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00030602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDM29626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="195" mass="21803" checksum="E6E79B9FCB90F8FD" modified="2014-04-16" version="1">MGDHVLFFYGTLMAPQILHRVIHGQANPEPWQKAMLRFQPAILQGYRRHRVQNADYPGIVAVPETETETNLSAPKTSAGTSVVGTLVSGLTDGDVHRLDRFEGSEYEKKRVTVRTLRAVVGGDHVNSSEGAAENQLREMLNATTGAEVAAEGEEVLAMTYVYTAGKDMLEDSEWDFESFKRDKMAWWVQADESEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q1H1</accession>
    <name>W6Q1H1_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Metalloenzyme, LuxS/M16 peptidase-like, metal-binding</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PROQFM164_S01g003609</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M16 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q1H1"/>
    <dbReference type="STRING" id="1365484.W6Q1H1"/>
    <dbReference type="MEROPS" id="M16.008"/>
    <dbReference type="OMA" id="WIFDEMK"/>
    <dbReference type="OrthoDB" id="952271at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000003">
        <property type="entry name" value="Insulin-degrading enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000005">
        <property type="entry name" value="nardilysin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050626">
        <property type="entry name" value="Peptidase_M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032632">
        <property type="entry name" value="Peptidase_M16_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054734">
        <property type="entry name" value="PqqF-like_C_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43690:SF18">
        <property type="entry name" value="INSULIN-DEGRADING ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43690">
        <property type="entry name" value="NARDILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16187">
        <property type="entry name" value="Peptidase_M16_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22456">
        <property type="entry name" value="PqqF-like_C_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M16 N-terminal" evidence="8">
        <location>
            <begin position="102"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="9">
        <location>
            <begin position="298"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 middle/third" evidence="10">
        <location>
            <begin position="482"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="domain" description="Coenzyme PQQ synthesis protein F-like C-terminal lobe" evidence="11">
        <location>
            <begin position="876"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="185"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF16187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF22456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDM29796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="1173" mass="133067" checksum="12CFBDE1BE40F13C" modified="2014-04-16" version="1">MPPRSSAANLCHKGLIRSSTRPCPDLLSRITVTSIRSARPVPLQILSSVLWTRRSSSHSTPNFTATPPTMAQIERITENLERPELDDRSYRVIRLPNKLEALLVHDPDTDKASAAVNVNVGNFSDEDDMPGMAHAVEHLLFMGTKKYPKENAYNQYLASHSGSSNAYTAATETNYFFEVSATGDSSAPKSSGDSTPAETNDNNGVSNGSALDGKSPLYGALDRFAQFFVAPLFLESTLDRELQAVDSENKKNLQSDLWRLMQLNKSLSNPKHPYSHFSTGNLQTLKEDPQKRGLEVRSEFIRFYEKHYSANRAKLVVLGRESLDTLEQWVSELFSDVENKNLAKNRWDGVQPFTEKDMCTQVFVKPVMDTRSMDMYFPFLDEEEMHETQPSRYISHLIGHEGPGSVLSYLKTKGWANGLSAGAMPVCAGSAFFTISVRLTPEGLKKYQEVANVVFEYIAMIKQREPEQWIFDEMKNLAEVNFRFKQKTPASRFTSRLSSVMQKSLPNEWLLSGSLLRRFDSDLIKKALSYLRADNFRLIVVSQEFPGTWDQKEKWYGTEYKVEKIPQEFLGGLQKALESTEATRTSNVHMPHKNEFVPTRLSVEKKEVAEPAINPKLIRHDDRVRLWFKKDDRFWVPKASVEITLRNSLVWATPGNLIKTKLYSELVRDSLDEYSYDAELAGLDYNLSANILGLDISVSGYNDKMSVLLDKVLNTMHGLVVNQDRFDIIKERLARAFRNAEYQQPYYQVGDYTRYLLAERSWINEQYLEELEHVESHDVVNFFPQLLEQTHIEVLAHGNLYKEDALRMTDSIEKILGGRPLPPSQWYLRRNMILPPGANYVYPRSLKDPANVNHCIEYFLYIGLFADDVLRSKVQLFAQLTDEPAFDQLRSKEQLGYVVWSGARYNAITMGYRVIIQSERTAPYLESRIENFLREFGSILEKMPEEEFEGYKRSVVNKRLEKLKNLGSETGRYWSHIGSERFDFLQHETDAANVRSLTKADLVTFYQQYIDPSSATRAKLAIHMNAQAGAQVEEPKPAEQRTRLIEVATKHLEAADFIVDSARFTTAFDSVDTTAADKSQVIFAVKNFLTETGLSQQKFEPVLETLDEKLSAQLKELGLGSGSDIQGAANGNGEAQKPVIITDVSTFKASLPVSAGPVPAMDLSVYEDFDAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q2C0</accession>
    <name>W6Q2C0_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="2">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">PROQFM164_S02g000285</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">FM164</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Component of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.49" evidence="2"/>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1365484.W6Q2C0"/>
    <dbReference type="OMA" id="CHMESAI"/>
    <dbReference type="OrthoDB" id="4358334at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056924">
        <property type="entry name" value="SH3_Tf2-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24626">
        <property type="entry name" value="SH3_Tf2-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="13" id="KW-0229">DNA integration</keyword>
    <keyword evidence="17" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="16" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="15" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="14" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="19">
        <location>
            <begin position="1456"/>
            <end position="1628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="43"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="265"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="343"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="371"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="734"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="18">
        <location>
            <begin position="49"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="267"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="292"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="348"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="18">
        <location>
            <begin position="371"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="736"/>
            <end position="757"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CDM30136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="1829" mass="207689" checksum="7053EC1D2DB290FF" modified="2014-04-16" version="1">MAGGEGNSAAPGGFTLEQREVMVQMIQQAVTQSLPQAISGALSTIPLRQPGPPGPPGPPGPDGQLAHPDTTWKIAEIGCFDPDNKATTAIRSVNHINHYTNVYSWVDHMRDIAKLKSEDVVRSHMSYSLKNKATNWYDAELTSLEKEALRVLPLEDGWYKELIKRWKPPLAEALRKMDFTTYSWTDVRAGKEPREYAQEIVRHARAAGRTDLYEQLLKIRENIEPSLRAVVMNPTTSTTLAEFLEHLDVKFLDWQDQVQLRDRRLQTPNNPQSGLNTYNQQRPQNRQSWQAQPRWQNQQRGNWQQTQARDQGNLARPEQRQLPALQQGQPGTEQRQLRISDRPYYQNEEANANQVRRQTWNQRRPTAYVTDLEDQADQELDQGEYCQGDGYDDSDDFEAYYGEPYLDEPYQEPPHQEQPGNEDSGPATAQLCHPQFSVTCLNCDVSFESGNTLHKHLDSCKPPAAGTTEEVAPAFFANGTLPLYESDRAKTHDPGYAFRTWRYATATIALGSRNQCITACLDSGCVMTLIDSDIAKKLDIPISKLSKPISVSGIGSQHTSEEWIKLDIYFMGPVATAKLTIEAHLVQDLKARLLIGMDVLGPEGISMNFDQRTARIASCKDMEFGISIQSKPNKMEPKPVYSADKITIPPHTMVNVPIRIRSKLPEGRDFIFQPDEKQGTMYTHMVNSNFVFVPVTNQTSVARTIPRRVRIGTIMENDDPTGYMVHPAEAALAATPDNQAQPKSNLRPKNSKETTLPNGITVYGDEATANALKEVLLKYNVWSNPEVVDIPPDRWMRIPMLEGWEKRVKRKRVYPTGEAEKELIDKVFNKLQAEGKLKWATDHTPTGYPVFVTYRDVIRDGVRTRVGRPVVDLRDANKEAVKDMYPVPTQDDILILCYGKLFITVFDAAAWFYQWRVHMDDVGKLGVITHRGHEIFLVTMMGHCNSVAYVQRELDHLLRKIRKFCRAYIDDLVVASDSLAEHISHLHELLSILQEYNIRLEPKKSFVGFPSVNLLGQRVDSLGMTTMEEKLRAVLSLDFPRTLKELETYLGLAGYFRTKIWRHAQIVKAMQDRKTNLLKAGPTKGPQRRAFSIRTLFENPTGAERASFDNLQAAMRHALVHMTVFFDHTRQLYAEIDSSKDEGHSAMIFHVKKDWVHTDMKKPPPANVVEPIMFLSRQLSQAERNYWPTELEVACLVWVLQKTRHLLLAIPASLPAIVYTDHSATVNISVNTNLRSAATENQNLRLVRAAQFIQTFNLKVYHRSGATNKVADALSRLRSNMPTKPKEDTDLDNFTQGIDAFPATPVTGAVAQESPRIHRRVFTELSDEIKETILSGYQTDTRWHRVIQTLRGEEASADPVPTKLPYRLDCNGLLYLTYNDGAEALCLPKSMTKDIFSLIHDNQAHQGYDRCWQRLKGICFYKGAKLLREYIKRCPICLEHRTPRHRPYGLLQPILSPPIPYHTLTMDFIVALPATPEGFDALLAMTDKFSKQNGFVPGKTTWEGADWAEAVVTFWWTADWGFPAEIISDRDPKFIQGLWKGIFMLLRVELFYTTAYHPQADGQSERTNQTIEITIRHWCAQQALQAGPDDEKPTSNWAKALPFLQATLNSSANASTGYSPHKLMYGVELKQPLDMMRQAFATSQDFTARLDAEHSLAYAAMAMKNYYDKSHIRKWYSPGDFVYLRLGHGYDIKANQGLPRKLAQRFVGKFKVLQRVGSLAYKLDLPSSWKIHPVISVEHLEPDPPGEDLWERTPEPAQLPEIGPQAVQAVISKRTRNVGRPRADGTRAQRTEYLVRFVGRGAADDQWISASELGYASWFEQYDQRGSRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q3I6</accession>
    <name>W6Q3I6_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">PROQFM164_S02g000670</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1365484.W6Q3I6"/>
    <dbReference type="OMA" id="QLPGYTW"/>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009927">
        <property type="term" value="F:histidine phosphotransfer kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16922">
        <property type="entry name" value="HATPase_EvgS-ArcB-TorS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.130:FF:000003">
        <property type="entry name" value="Histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.40:FF:000044">
        <property type="entry name" value="Putative sensor histidine kinase/response regulator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000285">
        <property type="entry name" value="Putative sensor histidine kinase/response regulator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000010">
        <property type="entry name" value="Sensor histidine kinase RcsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000579">
        <property type="entry name" value="Sensor histidine kinase/response regulator, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43047:SF46">
        <property type="entry name" value="HISTIDINE KINASE_RESPONSE REGULATOR, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12550)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43047">
        <property type="entry name" value="TWO-COMPONENT HISTIDINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9 19" id="KW-0418">Kinase</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 13" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Protein kinase" evidence="16">
        <location>
            <begin position="62"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="17">
        <location>
            <begin position="1914"/>
            <end position="2137"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="18">
        <location>
            <begin position="2176"/>
            <end position="2299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="60"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="444"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="523"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="2305"/>
            <end position="2348"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="1870"/>
            <end position="1900"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="61"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="447"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="560"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="2327"/>
            <end position="2337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="2338"/>
            <end position="2348"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="13">
        <location>
            <position position="2230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CDM30521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="2348" mass="261132" checksum="01805F84A2F81F1D" modified="2014-04-16" version="1">MEESTLFGDDLPLPPARLFERLGQLPGYTWDQTIEPFHSTYNHWHISGYRHALEPDVLTPLANSSNPASSGPSSLTRFSPRTEARPSARALRRLSVSETSSEISLSNQHSLETDQTWLPVIARISTNIIRLEREFHMLRSIVQSSDPDCNHTIRPVDLIRLQPDDGHSKTLLVAIFESPGHDRLRDLVTFGPASFAAGSKGEDNNDTPSEQVSLQAFFDFAIGACDCLEILHYGLKTVHGEIRGDAFHFCAETGAVKLANTGNGARSFDNVLSEGWSSVSRELGAKYKLQFIAPEQTGRMPTEPDSRTDIYALGLFFWSMLVGRLPFEGTDPVDVVQNVLGKRLVPVSGKRMDVPDALSAVIQKMTQKVVHDRYHTISSVKRDLTNIAKLLGDGDSEALSNFQVAQGDVSSFFTLPTYMFGRQEEYDKIISIIEKVNKRQAAALAKSGTQSPGTTHALTSASSLSESRIESLEFASVSSDSGSFHMPPRSSSNVTSYHIAQVNSHESVPGSETSFSTQKHTIVPEVYSQSPGAASSRVKSPSHSRSSHNTDRDSHHSIGPPSQQSTNHTVSQPGSLHSLNKPKNSGKSRRNERCEVITISGPSGIGKTDLLNRIQPTVRKIGCIAITRLDRAKRVPFEPFAKLLASLLRQIFSERDVTTDYHNSVRIALRPMWPTLHRVLDLPDQLMSPGAKYRPAEKANNFLMPTKGEPSKHVNIPGLDQGQTSQDFFLANAASKNMRLTETFLEILRTLCHFKLITICLDDLEHADDETLDLVMKIIKAKLPCVLILSSRKEEIPSAQVRSLFVEDLPAITRIVLDPLEEQHVMELVAATMHQKPDQTLTPLCAVVQEKSRGNPFYVRVMLETCYRTNCIWYSWKDSKWLFDLDRIFTEFVAPVYGEGLGLGFLTKRLQDIPQAARSIMVWGALLGSPFSFSLVQKLLTSEFLYSSNDDDYYDLTSPQDITLIRQSEGDIVVGLQFLVQANLLNTGRTDDEFRFGNERLAQAALSLNESRNVEKMHFIVSQVLMKYYHDHRSRYSMAHHVALASRTIKSRVSRRLEYRQILWDAGQTAFQSGARPSALWYFRHCIALLQDDMWNDLKPDVYYDETMRLFITTSEMSSSQGHNDDALQLINEVFVHGKDALSKSRAWTIKAKIFAQIGDHHSSMDSLLTCLDELGVHLRQPTTYEECDAAYLRLKSYLETADLSSIAQKPVSKDPTIVTIGAVMAEAMTVTYWDDALTFYRMALEVMNIHIFKGGFTQIAIGCSHLAMIALGRFKDIEFGTRLSDLSLELLELCPELSTQSRGSIVHNLYVSHLRVPMASTLPALEASLEASFSMGDPYLTLISISSMAMTRLYLGQDMAQLEAFCVETPAEIPKWHQDTRGGASLIAVQQVSRALQGKTEFRSADGIMSDANHNTSDYMMHLDVHSSNADRPRDIYWGLAMVPLFLFGHHTRAIQVGTQLLFTRHRLWSARVSYVICFYLAASILTFHNDNPSQGYLDDKMDALMEYKAEIDFARDASETNYGMWALILEALIAEVRNDHSAAIQGFESAIDHCQIHGWPLEEALALELQGEFLVRRGAKRAARAVIQDAIASWSSIGASGKSSQLAEKHEWLLKTATSSKTVDVGCQTVDSLLEISRDVVQEECMVPQQMEEDERRQQWIEQNGVAAGERSLDISSVGLDIIDLSSILESSQVMSSELQIDKLFTKMLEIILESCNGSDFAIIATDFDDNNGFAIAAAGDSEKGQKSFPGGLPFSEMEDRMALHISDYVMRTKEEVLVHNVLEDERFSNVSETYLANFPAGRSVIALPVVQGDRLLGVIHLEGKPNWFTQRNVVVLHLLCNQIGISLSNALLFREIRKVSAKNASMIESQKRALALAREAEQKAKNAEAEAKHNVKLKEDAARAKSIFLANISHDLRTPMNGVIGLSELLKGTYLDTEQDEYVESIRVCADTLLTLINDILDFSKLEAGKMKISTVPLNLKQTISEVIRALRYTHRDRGLETIENLDKVPPELVVLGDPVRLHQIFMNLLSNSYKFTPAGSVTVKARVAREGKGRVRLECSVTDTGIGIPDEQKARLFRPFSQADASTERSYGGSGLGLSICKAIIEDVLGGAIWLESKSGVGTTVTFHLVFNKAPKKTAVKTAWSQDLENADKELRRSSARDLTQIPRDQIRVCIAEDNPINQKIAVKFVTGLGLQCNAYSDGKQAVDALRASSKEGNPFHVVLMDVMMPTLDGYNATRELRRDPDPNVNEVLVIAMTASAIEGDREKCLEAGMNNYLPKPVRSPILSELLDRYLAPMPPSYPKSRLAIREKRSKASIDGSAGTPTSYSSSASDEPKPLSLEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q3Y4</accession>
    <name>W6Q3Y4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Zinc finger, CCCH-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PROQFM164_S01g002645</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1365484.W6Q3Y4"/>
    <dbReference type="OMA" id="PVCQVPI"/>
    <dbReference type="OrthoDB" id="2423195at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031380">
        <property type="term" value="C:nuclear RNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002376">
        <property type="term" value="P:immune system process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031048">
        <property type="term" value="P:regulatory ncRNA-mediated heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17936">
        <property type="entry name" value="EEXXEc_NFX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06008">
        <property type="entry name" value="NF-X1-zinc-finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001660">
        <property type="entry name" value="NF-X1 finger and helicase protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046439">
        <property type="entry name" value="ZF_RZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000967">
        <property type="entry name" value="Znf_NFX1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887:SF445">
        <property type="entry name" value="NFX1-TYPE ZINC FINGER-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20173">
        <property type="entry name" value="ZnF_RZ-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00438">
        <property type="entry name" value="ZnF_NFX"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51981">
        <property type="entry name" value="ZF_RZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0391">Immunity</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 9" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="11">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="domain" description="RZ-type" evidence="12">
        <location>
            <begin position="1846"/>
            <end position="1922"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="9">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="27"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="455"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="455"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDM28834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="1924" mass="217170" checksum="D1110138182A0643" modified="2014-04-16" version="1">MDSKRLCRDFAKGNCRWKNCKFVHASNGQSQSHSPTIPASPASQVQRPEPLPQRSCILPNADKEFRAWQNSIPLRSTVTRPSSGKKTTLFQKARELIGSDASIRQEVIRTLASEDGLRLILDLVQENFEEMNAATRDLLFKTQVLPFLETITNPEVASSLVLEQAVGTIYNVLFGLDGSRAARWLNFICGVLEIDTTNEGSAMLLEASLHTFSRIADLNSTAPVQDCLHAVAQRFETVLTSMNDKNGMSGRLYQSRMHLDRLLQRMETGNSLSTGTTENKVKNESNVAFVANRETPGGRHNNDFDDICQIKIMPTFEEICSLREEYLPVNNPLQWHIDGVDGLLDRNFRLLREDTVGQLRDAIHHELSPRAQRSQLRRFVYPNSIVVKLEFNWLWGFYFEVDFPQPAGVRNFTPKARETWWQNSKRLQPGALVCLIVQKDVVVFCTVTHRDMSPRYRKDTPSQDHVPPENKANPRTLWKSATRGSVMLMPVDSRCNNTQVVLDLFDSKKANMSLVEFPGVILPAFEPALRALQSMKRTKNLPFSELFVPWTFDDFNLFDMAPPLYALQPGFASNLRCLMKNDTNFYVRVDQPSNVKYVQDNSTLDGAQAHALISCLKRKLGLIQGPPGTGKSYTGVALIKVLLANKDAAAGGNLGPILCVTYTNHALDQLLESLLDNKVTSQIVRIGSQSKSERLERFNLHIVARDTPRTKMEKKERWSTAEILSYCEEDFRALDLKNEVSIARLKSYIQRTNPSQHNQLFSLVQEDGSLRVQKDNPQTAINSWVDSAPAGSARARPVEELKNINVFEMSREERQLLYNRWCHDYRAEVEERVRRIVSSHEIAKKGYDSVQDEMHLRCLAEADVIGITTAGLARRLDMFRRLQCKFMLCEEAGEVLESHILTAFLPSVEHAVLIGDQQQLRPQVQNYDLSSENHRGGAQYSLDISLFERLVSSNKSPMDCGAPFSTLETQRRMHPSIARLVRKTLYPSLKDAPSVSEYPEIMGMRKRLFWLDHRHQEGGSDGDSMSTSHWNSHEIDMTVALVNHLVQQGEYKHGDIAVLTPYLGQLHRLRKRFDELFAIMVGNRDRVELKQAGFAGYETKDKPTIKAALSETLRMATVDNFQGEEAKVVVISLVRSNAKNQCGFLRTSNRINVLLSRAQHGMYIIGNSQTSIHVPMWAQVVKILRQEHNIGKALELQCPRHPDTPIVVSTPEDFPKFSPEGGCNLRCVNRLRCGHACIQKCHSDVLHNAVFCLEPCPRSLGGCNHPCPKRCGDRCPEKCMVNVYQKDRTLLCGHPMPDLPCWQDQDISKVRCLVPVDKTILGCSHTTSLPCHIDVEAQDYRCLAQCRSLLPCGHLCKKICYRCITKGPESVPANHGNCEQRCDRNQSTCAHTCSIPCHAEKPCPPCKAPCEVHCGHSKCPRKCYEPCTPCAEEKCLSACPHSVCSMPCAAPCDHVPCSKRCEKKLECGHQCPSVCGEKCPSSSFCQTCGNEDIHNHQVDFILGETYREINLDENPCVFPKCGHFLTIENMDAQMDMASYYDVDASGKPVSICVSLAPFSIQDIKTCATCRGPLRDISRYGRLVRRAILDESTKKLIIFLNQEYVPLAQELPQLVRELHECDGQRMYPWPAVIEISGARSHQIQSMGEIIESTNPGRWDAILDLRKRVDLYRRHVKPEEQPFERVRRMIENARQRQGLTTNPKHVDNVLQTKGFLQGTALLIRLDIALIVDLLDLGSQGRPHLVAPRFELDLQKMKDDCQTLIRHAASHHRLLQQAEGHIFLAQLYALERAHCLTPEKRNNILMHGQASIQKAKGLCDAHPGQTRGLADEVHSVEKMLRGGTFYTIITNEERMSVLSAMAQEFRGTGHWYYCRNGHPFTIGDCGLAREISRCPECDAPVGGESSELADGVRLAVDWDLDRERLNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q425</accession>
    <name>W6Q425_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Armadillo-type fold</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PROQFM164_S02g001498</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CAND family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q425"/>
    <dbReference type="STRING" id="1365484.W6Q425"/>
    <dbReference type="OMA" id="AYIPHFQ"/>
    <dbReference type="OrthoDB" id="6260732at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010265">
        <property type="term" value="P:SCF complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039852">
        <property type="entry name" value="CAND1/CAND2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013932">
        <property type="entry name" value="TATA-bd_TIP120"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12696">
        <property type="entry name" value="TIP120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08623">
        <property type="entry name" value="TIP120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25782">
        <property type="entry name" value="TPR_CAND1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="TATA-binding protein interacting (TIP20)" evidence="5">
        <location>
            <begin position="855"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="57"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="188"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="58"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDM31348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="1035" mass="112153" checksum="447FA86AEEF703F4" modified="2014-04-16" version="1">MSSYSDDEHDPQADELRETALVTLEALISSCNKKMQPYLTNTTRSALRFLKYDPNVAEVEDDEEMGGTQDDGSEDDDATEEPDLEDDDEFEDFEEEGGYSDIDDMSWKVRRCAAKLLYTVISAYGLGRASDSSALFQQIAPALISQISKEREESVKLEVVSTLTALVRKTGEGSMIVTSNDFLEAVGGSKNSRKRRRQDSDASMIDFEPSAGTSSAMDSPAVPSSPKSGSQADLARSVPLIVQNLVKAWKQASVPLKQAVMILLKSLSLVRYGGLADHLQQIEDLIADALKTSSLSGSTAAHTGAAVSAGTLQIETLGLISVIAETHLSDALLPFLIALVPGVIGAVNDRNYKVSSEALGAVEQIIKAMTPPRVSANPSDVTLQLQKLYDVVHSRITDTSADLEVRQRAIHVFGVILARTSGDRGAEFLSSERRSNGLAVLVDRVKNETTRLSAVRAIDDVVVLASRKQDVSSDWVNNVALELGSNLRKSDRALRGACLETLRSLSMNSNIRSHLTPETITALENAALPLLAAADFHTLTPTLIIIAKLVPGNAKLMVTSGLISAICSIVTKPLIGTVLKALLLLVKVIGDEGAGASLMQNLLRDVGITGDSSVVGRAVGTLLVHGGPNLGVTMEDFSTELKTARDVSRKCLALAILGEIGLRMGPECPLTPSLFIPHFESQSDHVRLAAATALGNAAAGSVKAYLPIILNGLEKSNAQSYLLLHSVRELLQHPEVVRPDLAPSAHKLWHALLVVSEQEDNRAVGAECVGRLALLNPVAYIPHFQEYLANADPAVRGVVISAFRYTLADSSDAYNDVLRPLMVPLLTNMLSDSDLGNHRLALTTLNSAIHNKMDLLLPHLDELLPAVLGDTKIKPELIREVQMGPFKHKVDDGLDLRKSAYETLYASLDTSFSRTHTAELFDRILAGLDDEQDIRAISNLMTSKLIKIAPEDTERHLDALSEHYTTVLSFKPKDNAVKQELEKAQEASLGILKITRELSKAFPGPEASGDLSKWKTYMDWLRRNFSSQLANLELE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q4K9</accession>
    <name>W6Q4K9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S02g001728</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q4K9"/>
    <dbReference type="OMA" id="VPWDSWI"/>
    <dbReference type="OrthoDB" id="4367476at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="8"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="56"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM31578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="174" mass="17606" checksum="A7A1AC3864AAC727" modified="2014-04-16" version="1">MSQKRKTPATAPSASSAPSAPSVSNGPNAPTTRPRGGKKIRAILSREKAAKELKDALASAASAGSAAGTGESSTAPPVASPSTDSHTVASQAPPPAITTPVVDPPAVSPSMPSTTSAVVPTVGAAYRITPASLVPGLELTDEEVEDLSGYLPSVIATFIQDRRVTLEVPWDLWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q542</accession>
    <name>W6Q542_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DUF202 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PROQFM164_S02g001620</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q542"/>
    <dbReference type="OMA" id="HACCAPI"/>
    <dbReference type="OrthoDB" id="5525680at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003807">
        <property type="entry name" value="DUF202"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052053">
        <property type="entry name" value="IM_YidH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34187:SF3">
        <property type="entry name" value="DUF DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G11150)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34187">
        <property type="entry name" value="FGR18P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02656">
        <property type="entry name" value="DUF202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="74"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="DUF202" evidence="6">
        <location>
            <begin position="59"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM31470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="170" mass="19098" checksum="24734B92ED94C15E" modified="2014-04-16" version="1">MSLMVTQVGVGRARFNPLVNPVNSKPVLVEEHIESQHHIFLSRPYLGALLFENSSSDARDHCANERTFLSWLRLSMYLAIVSMAIIISFHFRDQPTGLERRMALPLGIIFWILSLTCLANGFANYSRTVRKYARKAALVQSGWKTQVVFTVVGTVILGSCILFLSTDPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q544</accession>
    <name>W6Q544_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S02g001256</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q544"/>
    <dbReference type="OMA" id="GVRNNMF"/>
    <dbReference type="OrthoDB" id="2157103at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM31106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="119" mass="13330" checksum="622302E45E6DD6B4" modified="2014-04-16" version="1">MIVKGLGPRSPLNRRLFSQLQVHCVRSLSTSLFRPSEAQDPQGYQITKSKQEKTNQTPDDSSNKDNKSPKPKTVSEADAELRERLEHMSGEGGASGIEYEDGKPNAMKRGVRNNMFRII</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q6A7</accession>
    <name>W6Q6A7_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Single-stranded nucleic acid binding R3H</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PROQFM164_S01g003617</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Regulates global gene expression after oxidative stress. Interacts and stabilizes mRNAs and may regulate their transition between different cytoplasmic components after oxidative stress.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Interacts with csx1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q6A7"/>
    <dbReference type="STRING" id="1365484.W6Q6A7"/>
    <dbReference type="OMA" id="GMQRDDS"/>
    <dbReference type="OrthoDB" id="434258at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02639">
        <property type="entry name" value="R3H_RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12253">
        <property type="entry name" value="RRM_PIN4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.50:FF:000002">
        <property type="entry name" value="Immunoglobulin mu DNA-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000183">
        <property type="entry name" value="R3H domain containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.50">
        <property type="entry name" value="R3H-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034186">
        <property type="entry name" value="PIN4-like_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034069">
        <property type="entry name" value="R3H_Cip2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001374">
        <property type="entry name" value="R3H_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036867">
        <property type="entry name" value="R3H_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050374">
        <property type="entry name" value="RRT5_SRSF_SR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024642">
        <property type="entry name" value="SUZ-C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003">
        <property type="entry name" value="RNA RECOGNITION MOTIF RRM DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003:SF17">
        <property type="entry name" value="RNA-BINDING PROTEIN PIN4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01424">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12901">
        <property type="entry name" value="SUZ-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00393">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82708">
        <property type="entry name" value="R3H domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51061">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 13" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="15">
        <location>
            <begin position="153"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="R3H" evidence="16">
        <location>
            <begin position="298"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="239"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="366"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="531"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="239"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="263"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="277"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="368"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00055199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00062407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CDM29804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="599" mass="65463" checksum="42923B98B05ED6AA" modified="2014-04-16" version="1">MSYQQDMYHDHSARSPGSQRHQQPLHRQPSRQFDAYGPMPTNMYEQDQMRYESARLERLNPSLQNNYGYDISGSQTWNPNGFANAQALGGIRSASASLKPNARGRAGLPTTWLDQQPNMPQAFSNLGPGPIQSSAMRPEASASSADDDELIPTAIVIKNIPFAVKKEQLVQLMTELNLPLPYAFNYHFDNGVFRGLAFANFTSAEETATVIEVLNHFELQGRKLRVEYKKMLPLQERERIEREKRERRGQLEEQHRPMGGGPQLQTQSSMSSLTSHIPATSPSPVSQRGQKIDVDLNDTQTLSYYSQLLLFKEDTVRDSVIFPHNLTPSQRRTVHTLAHNMGLGHASRGSGEQRQVQVFKIAAGANVSPPTSSIPPSGQSDSGRRGLNRAATIDFGEARQEAGPGTFNTLRGQNSGFLGVMDSPGNFANGQNLRAAKSFADLRSYTPSPVPSSASFPAALQSNGARLQYEGAPTGTSNTPTLTPVQSGSSLGMQRDDNLLVNSLGGLSLGTGIGGPNSSPRRLRGMFSWEQDSQQSNAGAIGSNRGMSMGYDGQQERMPVRQPRGPTPDKGPGFRRQNGHQSRGSDELRTNSGVEIIVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q6I5</accession>
    <name>W6Q6I5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Potassium channel, voltage dependent, Kv1.3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S02g001771</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q6I5"/>
    <dbReference type="STRING" id="1365484.W6Q6I5"/>
    <dbReference type="OMA" id="PHEKVFP"/>
    <dbReference type="OrthoDB" id="2414723at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034220">
        <property type="term" value="P:monoatomic ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003131">
        <property type="entry name" value="T1-type_BTB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31758">
        <property type="entry name" value="BTB/POZ DOMAIN-CONTAINING PROTEIN YLR108C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31758:SF2">
        <property type="entry name" value="BTB_POZ DOMAIN-CONTAINING PROTEIN YLR108C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02214">
        <property type="entry name" value="BTB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0407">Ion channel</keyword>
    <keyword evidence="3" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Potassium channel tetramerisation-type BTB" evidence="2">
        <location>
            <begin position="21"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="360"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM31621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="429" mass="48309" checksum="E17ADCA581964A7D" modified="2014-04-16" version="1">MDKPTPTRSKCSLPREKVFSIQIGSETFRLSGASIASDAPSYFSRFFELQLLQNPDVANTRTLYIDRDPTTFHEIARHLQGYHVRPQDGAQFVKLFADAQFYTLPRLMSQLFESECFIQIGDRHFQIPRDIFSGPGDTPNFFTLGFAAFFASPSEVFPGLDRQGLLRPPAIVPPSVPNRSANVFDELLHLLRGYPLHIRNEDHRAALLRDCRYFHLRGLEQKLIPHQITTNPFSHRLEIVIRLEDVRPSGVQCILNTVSGSGRMVTYARPFIDDNAADLVVEIGDESSLIHRGTMRVDFLGLSKQRIVSLLQTVGKKLNLPDSHPPLGQVPLKVRVDSETDLTVDGEQDPHHLMISRAKAEAGAGADSVPPAKRPRVDNTDDKPWVVRTGQWRLQVQTGPTGIYEVVLVAVKLDIYTSSQVRNRSRKFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q7U4</accession>
    <name>W6Q7U4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S02g002919</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q7U4"/>
    <dbReference type="OMA" id="IAQWINY"/>
    <dbReference type="OrthoDB" id="5381672at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="67"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="199"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="620"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM32768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="748" mass="84011" checksum="53D7056AA2857E93" modified="2014-04-16" version="1">METADGEVPLRQLPRSSNNLHAPEYSRHDSSAESDPRHDEELPSYTQVRSTGQILGRGHSTLLHRSAWVFAFTIIYVVLVVYAWAMTAVLSTRPFKDKSWAYSFGTSRSSYYYRYNEADFDQERNIYRSVRTIHTFIQLVTLPWISTVCASAAVIYAQNQKDPMGLRLRQVTTLADRRWMDFSFYPALIYKWRQYGSKLLATAIFICVFGLITFPIQSVFLSSQSVKVRTLPQEIATIYDFSPNSGYSSSSYDTGKDVLKVRNALNKANVDFYQPNLWSNNSGVQFLTLNDLSSQTYYSQVPSGFNTGLLRQFAPRVNSTATYEIVRASDFPVDCSSRPGAFYAEYSSSYPQYVNSTSSYSWGVTACMPGNMTRSPWQLARKARNRQDFSEVLYLNMTQEDYRTRDHQTLFQITVNTTAGFFELPNYMNKGVPGPLLDQDPAELCDQHCPSQFNTYYSGYRRDGITVEGALKAGSLGPISTDNKGPLLSAALASFGPGSFIDSFIATAATVKADDKVTDEVSSSLGKVCAANTPLTNLMGSSSLECVSVVIDSYGDYYYPVGSYIAQWINYFQDNAEPVQKAFTSAAFLANQEFLSSQRGRFSVAQDLGADMDLPSISPVGIIVVSILMALYLLPLLALSLYAGFSYRWTERLDSFVMLRFGAFVGDKFFPLLIGRESDKVPELDEMPGVIRDVATYSGDEVIKIGRLGFGEGSRLREGHRYECFQGNDEPLNHYESRRMQRVIHRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q808</accession>
    <name>W6Q808_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S02g002994</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q808"/>
    <dbReference type="STRING" id="1365484.W6Q808"/>
    <dbReference type="OrthoDB" id="2143914at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM32843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="264" mass="29534" checksum="0B5C2BB0C8478E3B" modified="2014-04-16" version="1">MSSTNFRLEFDYGPKKQNILCPKPERHPLPARPPTEGLGQTLSAVSGQEPFNFENILQPQNIDGGDDVASPSFADDIYWEREREFLELGLDGSDPVDFAQLLNFENVDPAILDDHESPVAEQAEITMDIASIVTPPEECPAVSIRPQNKVSTLYRRRNLKGMVDSDRQPTKIKKGLGTGKGDIRIGSTRPKKSSGRQSTSFTIVCAQFSALLVEDRLQFLSWLFEEVVKQFSREFPGRSEGSIKVYYSTTLKKRRLSSPIVLIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q8L4</accession>
    <name>W6Q8L4_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Signal peptidase complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PROQFM164_S02g003179</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Enhances the enzymatic activity of SPC and facilitates the interactions between different components of the translocation site.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SPCS2 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM33028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q8L4"/>
    <dbReference type="OMA" id="KHACDDA"/>
    <dbReference type="OrthoDB" id="29558at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005787">
        <property type="term" value="C:signal peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045047">
        <property type="term" value="P:protein targeting to ER"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009582">
        <property type="entry name" value="Spc2/SPCS2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13085">
        <property type="entry name" value="MICROSOMAL SIGNAL PEPTIDASE 25 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13085:SF0">
        <property type="entry name" value="SIGNAL PEPTIDASE COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06703">
        <property type="entry name" value="SPC25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDM33028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="187" mass="21042" checksum="098D9D2D3A270307" modified="2014-04-16" version="1">MASSKVPVYSTNDLKSTSDDALLPYLTNLPAPYAFTPDYSKTNIRFLLGYSAVAIAGFTFYADRRLGWEATTSPWIIAAVGTYFFLNAILTYWIWAVEAGEVYSGKRKTGETISVSSSTKKFSKLYKLHVIYKSASGKVLQDKRCEAPFTTWFSVDGVFHPEPFRRWVASEIDVLRLAAKENEKKFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q8W6</accession>
    <name>W6Q8W6_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Heat shock protein DnaJ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PROQFM164_S02g000814</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q8W6"/>
    <dbReference type="STRING" id="1365484.W6Q8W6"/>
    <dbReference type="OMA" id="HFLQIAY"/>
    <dbReference type="OrthoDB" id="376357at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
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        </location>
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        </location>
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        </location>
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        <location>
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        </location>
    </feature>
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            <end position="112"/>
        </location>
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    </evidence>
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        <source>
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        <source>
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        </source>
    </evidence>
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    <sequence length="432" mass="47696" checksum="241654EAD346A8F8" modified="2014-04-16" version="1">MPNDDLKAHAASNQDFYALLDIQPAATETEIRRAYRRTALKYHPDKIKNPTAADIDKFHFLQIAYDVLSDTSVRQLYDNAREARVRKQRERDMMGAAKRKMREDLEARERAGAAEIGSAGVKQGVKRSWGTDGDEDAEEKLQREIDRIAEDGRRRRREAEEKAKKELEDERKKIQQQEEEARKAADRSSQRVDRSKEGGGAQVPELERAVKVRWVREGRGLELDIEQLAVLFKPFGTIENTLTLKDKRQRIGDNKEKKTVATGVVVFTSIVSAHTAVLDSEKKLRQHAGQDGEWGLIESVFWASGNQPDLGPGISPKPDQAVPAPPPPGPSFDTSSKPTKSSFNFQGLKTAPPPDKAPSFGSFASAAAAAAAPSATSFNPSTQAPAAPSLQEVMMMRLKSAQREKERKALEEEMLREDEAADAAAAAAAKGT</sequence>
</entry>
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    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
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                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
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                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
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                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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        </location>
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        </source>
    </evidence>
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            <dbReference type="EMBL" id="CDM32835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="224" mass="26164" checksum="4F6743CE25FEC0B3" modified="2014-04-16" version="1">MKLFETPLDIWLSIKDFLTPADVENIINTSSILWKQIFKNTSWLEFALTFDGCSPVLIGHNLSAYRPRKSSTRLYLALIAGDYSGDLRYESEKFFAALQDGWKYDKNRYEVQFPSGITLNIYDVIECHESVKLPLEKVFTNTKQGVYSEYCYYRYPAIKELRSSDIAKWDPDYRPHPHALGYEDKPHHSSKSYEKQAMGKDGTKCARLLIDSRYKTQREEAKER</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q984</accession>
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        <submittedName>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
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                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
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                <person name="Goarin A."/>
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                <person name="Lacoste S."/>
                <person name="Sallet E."/>
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                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM32965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="89" mass="10246" checksum="631F6724356BDCD1" modified="2014-04-16" version="1">MASHSNTIIIANDEKLPNLQPGSPQPQRAPRCNNSYEDSEGMFIDAAEDETRSRKRKRTEKKKPSALDNAFQLLNKEVRHKVKRLKKEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q9N2</accession>
    <name>W6Q9N2_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">AP-1 complex subunit gamma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">APL4</name>
        <name evidence="13" type="ORF">PROQFM164_S03g000067</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM164</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="9">Adaptor protein complex 1 (AP-1) is a heterotetramer composed of two large adaptins (gamma-type subunit APL4 and beta-type subunit APL2), a medium adaptin (mu-type subunit APM1) and a small adaptin (sigma-type subunit APS1). AP-1 interacts with clathrin.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q9N2"/>
    <dbReference type="STRING" id="1365484.W6Q9N2"/>
    <dbReference type="OMA" id="AICAMRI"/>
    <dbReference type="OrthoDB" id="28053at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030121">
        <property type="term" value="C:AP-1 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016482">
        <property type="term" value="P:cytosolic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000030">
        <property type="entry name" value="AP-1 complex subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050840">
        <property type="entry name" value="Adaptor_Complx_Large_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017107">
        <property type="entry name" value="AP1_complex_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008152">
        <property type="entry name" value="Clathrin_a/b/g-adaptin_app_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013041">
        <property type="entry name" value="Clathrin_app_Ig-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008153">
        <property type="entry name" value="GAE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22780">
        <property type="entry name" value="ADAPTIN, ALPHA/GAMMA/EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02883">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037094">
        <property type="entry name" value="AP1_complex_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00809">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49348">
        <property type="entry name" value="Clathrin adaptor appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50180">
        <property type="entry name" value="GAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6 10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="GAE" evidence="12">
        <location>
            <begin position="734"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="604"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="649"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="613"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="649"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="704"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="720"/>
            <end position="737"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00062546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR037094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDM33343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="848" mass="92534" checksum="52D9130B2748D533" modified="2014-04-16" version="1">MSSLKQFIRNVRSAKTIADERAVIQKESAAIRASFREESHDSSIRRNNVAKLLYLFTLGERTHFGQIECLKLLASHRFADKRLGYLGTMLLLDENQEVLTLVTNSLKNDLNHSNQYIVGLALCTLGNIASVEMSRDLFPEVESLMSTANPYIRRKAAICAMRICRKVPDLHEHFLEKAKNLLSDRNHGVLLCGLTLAIDLCEAEEEEDEEGGPVGVIEMFRPLAGGLVRALKGLTTSGYAPEHDVSGITDPFLQVKILRFLRVLGRGDVATSELINDILAQVASNTDSSKNVGNSILYEAVLTILDIEADSGLRVLGVNILGKFLANKDNNIRYVALNTLNKVVAIEPNAVQRHRNTILECLRDPDISIRRRALDLSFMLINEDNVRVLVRELLAFLEVADNEFKSVMTTQIGIAADRFAPNKRWHMDTILRVLKLAGNYVKEQILSSFVRLIATTPDLQTYAVQKLYSSLKEDISQEGLTLAATWTIGEYADSLLQGGQYEEEELVKEVRESDLVDLFTNILNSTYASQIAVEYIITAAMKLTVRMSDPAQIERIRRLLSSRTADLSVEIQQRAVEYTNLFGYDQIRRGVLERMPAPEIREEQRVLGAASTTKKRQSKLLRGKSTTKVAKPAEHDLLLDLVGGDAPVTSPTSNGSNTADLLADILGGDSGMSSPSPGPAGQKNSNSAIMDLFGSNGPSPQPTQPASASMDLLGAGGLGASAPSPSGSPAPVTASTPAHTALNKDGLVLTLQVQRSGANAQILARFRNDASFGRFTSVGLQAAVPKSQRLQLSAISKADLDAGDEGTQQMRVTALNGGLPAKLRLRLRVTSARDGGNPVTDQVDWSEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q9S1</accession>
    <name>W6Q9S1_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ribonucleoprotein LSM domain, eukaryotic/archaea-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S03g000117</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Component of the heptameric LSM1-LSM7 complex, which consists of LSM1, LSM2, LSM3, LSM4, LSM5, LSM6 and LSM7. Component of the heptameric LSM2-LSM8 complex, which consists of LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8. The LSm subunits form a seven-membered ring structure with a doughnut shape.</text>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q9S1"/>
    <dbReference type="STRING" id="1365484.W6Q9S1"/>
    <dbReference type="OMA" id="THEYRCP"/>
    <dbReference type="OrthoDB" id="368909at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031417">
        <property type="term" value="C:NatC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06168">
        <property type="entry name" value="LSMD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034110">
        <property type="entry name" value="LSMD1_Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050914">
        <property type="entry name" value="snRNP_SmB/NAA38-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10701:SF5">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 38, NATC AUXILIARY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10701">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN-ASSOCIATED PROTEIN B AND N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <feature type="domain" description="Sm" evidence="2">
        <location>
            <begin position="8"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00025892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM33393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="102" mass="11567" checksum="37389FB94A77CB1A" modified="2014-04-16" version="1">MDHDQSVKYLEGLLGRTLRIHTTDNRMFLGLFKCTDADRNIILANSFEYRMPSTSAVQAAAHEKELEEGPEAKSATFKLDMTHRLIGLIVIPGRHITKIELE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2024-10-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>W6QA27</accession>
    <name>W6QA27_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S03</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S03g000242</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QA27"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM33518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="67" mass="7192" checksum="F715DB4047DAD5AA" modified="2014-04-16" version="1">MESCNGNLVMYTAAKDPVLGRRNLAGNKYTTDALGAIAGAQLCHEAVNMNIEALNVLDALRRTTEAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W6QA63</accession>
    <name>W6QA63_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PROQFM164_S02g003047</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QA63"/>
    <dbReference type="STRING" id="1365484.W6QA63"/>
    <dbReference type="OMA" id="IRFVPPC"/>
    <dbReference type="OrthoDB" id="294730at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000039">
        <property type="entry name" value="Neutral amino acid transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF479">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="94"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="156"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="190"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="227"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="268"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="314"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="341"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="374"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="7">
        <location>
            <begin position="24"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM32896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="417" mass="44801" checksum="0BBF1E22EA9FD73C" modified="2014-04-16" version="1">MPLATRSSRRSSTKYSGGGMFHMMVAETVSLGVLSLPAAVAALGLLPAILVLVFLGLMATYTGYVIGQMKWRYPHICTFADAGEVIAGKWGREFLGAAQIVFFIFIMASHLLTFTVAMNTITNHGTCSIVFGIVGMVISFICSLPRTLEKMSWLSIVSFVSIMTSVIIVMIAVGITAPGQGVVAVVDTNLYHGFSAVCNIVFAFCGHAAFFGLMAELRNPKDFTKSLCLLQGIDMGLYITAALVIYRYAGDDVTSPALGSASPMVAKIAYGISLPTIIIAGVINGHVAFKYVYLRVFEGTDRMHKRDWIATGSWVGIALALWTMAWIISAAIPVFSNLLSLITALFASWFTYGLSGIFWLFMNKGLWFSSPRKIALTLLNIVVISVGAALCGLGLWVSGKALHDNPSSESFSCGNNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W6QAJ8</accession>
    <name>W6QAJ8_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">uracil phosphoribosyltransferase</fullName>
            <ecNumber evidence="4">2.4.2.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">upp</name>
        <name evidence="11" type="ORF">PROQFM164_S02g001329</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM164</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uracil: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UPRTase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.9" evidence="4"/>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QAJ8"/>
    <dbReference type="STRING" id="1365484.W6QAJ8"/>
    <dbReference type="OMA" id="ISTHPCL"/>
    <dbReference type="OrthoDB" id="10257085at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004845">
        <property type="term" value="F:uracil phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000049">
        <property type="entry name" value="Putative uracil phosphoribosyltransferase urg2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050054">
        <property type="entry name" value="UPRTase/APRTase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001097">
        <property type="entry name" value="PRK00129.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32315">
        <property type="entry name" value="ADENINE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32315:SF4">
        <property type="entry name" value="URACIL PHOSPHORIBOSYLTRANSFERASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14681">
        <property type="entry name" value="UPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="6 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="10">
        <location>
            <begin position="9"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF14681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDM31179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="235" mass="24867" checksum="61D45FA8FB71F9A7" modified="2014-04-16" version="1">MSLPSNVHVSSHPCLQAKLSLIRSSSTTPRETRGLVHDIANILGVEAFSGLKLVKTGTDTTPLGIEYETQGIDPLDLALVPILRSGLGMVDALNDLLPTSVPVYHLGLFREKVSLQPVEYYNNLPFHRSELSPASPASLNPTTNTAAASLAVLLDPVIATGATAEAAIQLLRDWGVKKVIMLSLLASEEGVKRAAGTWGDVEVWVGAIDKGVDEKGMIVPGIGDIGDRLFVAVGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W6QAP9</accession>
    <name>W6QAP9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S02g001374</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QAP9"/>
    <dbReference type="OMA" id="WMGGESE"/>
    <dbReference type="OrthoDB" id="5411041at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM31224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="218" mass="24776" checksum="3CED128281BDD959" modified="2014-04-16" version="1">MATPSPTDLNASREADYKRFKNYAAYTFLIGAPILIALPPRKLDPLTVLVLCSFGASANHIVHERTGRSIIDRIDARISSMQRSFSSLPSERAQEIQARLRAARDAQIRIAEHEQLKARILSLSDKQRREPDPVLMEEIQKLKARQAQEEDVVRRLWMGGESEGWKERRLREEQKALSEGKGYGDLIQEHIWDVWTWGGKDGKAGEGVTDENVAEKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W6QAT7</accession>
    <name>W6QAT7_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S01g000636</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QAT7"/>
    <dbReference type="STRING" id="1365484.W6QAT7"/>
    <dbReference type="OMA" id="WSKTWLK"/>
    <dbReference type="OrthoDB" id="4088536at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1410.10">
        <property type="entry name" value="I/LWEQ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026907">
        <property type="entry name" value="GCIP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049317">
        <property type="entry name" value="GCIP-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15492">
        <property type="entry name" value="CYCLIN D1-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15492:SF1">
        <property type="entry name" value="CYCLIN-D1-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13324">
        <property type="entry name" value="GCIP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-D1-binding protein 1-like N-terminal" evidence="2">
        <location>
            <begin position="45"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM26827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="367" mass="39845" checksum="636E671164F3D7EF" modified="2014-04-16" version="1">MSKQLSGILGTTLTLISQFQTALTTLPTAATEAAKDAEALPLLAASSSALKAHVTKLSLLAITSPFTHSAVSTVLRELNESVLPSLVTASLLVTPAQYTKAFHSEVLVLVKTALTEFSALVREIKLVGEKKDQEKKDTGKESGVTKSEKDAVMLATGRVWDACDSTTDVANKGVVGFVMRRVEQWRDLVRDAVEEIEDWDPEEEDDGFLDDILSDEEKAGDDKDEDDDEDDEEETAALQEHKKSTLRFLKPIAQVYPAIINNRLKNAGNAPLASSSGVKKLDSLMLNLQAIPDDVDEAAGALYEANFETSAQYLQKTRKCATQAVELVASPWGAADAKDDAPADKFTTWSNTWLKVIDEVSKSIVKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W6QBA1</accession>
    <name>W6QBA1_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S02g001569</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QBA1"/>
    <dbReference type="OMA" id="AGTICRW"/>
    <dbReference type="OrthoDB" id="2342176at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36182">
        <property type="entry name" value="PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G10930)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36182:SF1">
        <property type="entry name" value="PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G10930)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004880056" evidence="2">
        <location>
            <begin position="18"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="252"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM31419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="374" mass="39632" checksum="12AB863C354FC0BB" modified="2014-04-16" version="1">MKGTLILSGLLATTVSAHMQLNKPYPIRSPLNKDAKGEKDYSYTNPLSTSGSDYPCKGYANDAFEAVDTWQPGSTQEMSLEGSATHDGGSCQLSLTYDKGKTFKVIESIEGDCPIAKKYQFDVPSDAPTGDALFAWTWFNKVGNREMYMNCAMITIGGSSNHTVVDSEGRVAKETPKQALSQKTHTHTTNAKSSFDSLPDLFIANANQAGKCVTVEGQAVHFPKPGPKLIGKADGPGYKCADHAPFLDDSSDSATKSSNTSTSTSATSTTSTTPKSEKKPAVISTSSFTTKAISKIAQALATPSVAADSRVQSAEDSSNNQFVDHVGQWSCHSGEILCSPDGLTFAMCTNGKPIFMGSVAAGTICRWGAITARQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W6QBA5</accession>
    <name>W6QBA5_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Hypervirulence associated protein TUDOR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S03g000702</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QBA5"/>
    <dbReference type="OMA" id="IENSHTH"/>
    <dbReference type="OrthoDB" id="10052172at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM33978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="68" mass="7570" checksum="7A3BB70B417A737D" modified="2014-04-16" version="1">MPHFKEGDKVNYKPVGGPQSRTSMSVGLVREILGGRSSSDEETRYTIENLHTHKTSSIKERNIEGPAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W6QBM6</accession>
    <name>W6QBM6_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DJ-1 domain, InhA-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S03g000579</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QBM6"/>
    <dbReference type="STRING" id="1365484.W6QBM6"/>
    <dbReference type="OMA" id="LVEFITC"/>
    <dbReference type="OrthoDB" id="5424793at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052158">
        <property type="entry name" value="INH-QAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43130">
        <property type="entry name" value="ARAC-FAMILY TRANSCRIPTIONAL REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43130:SF3">
        <property type="entry name" value="HTH-TYPE TRANSCRIPTIONAL REGULATOR RV1931C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="DJ-1/PfpI" evidence="2">
        <location>
            <begin position="6"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM33855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="230" mass="25096" checksum="09FD49F15281223A" modified="2014-04-16" version="1">MDHIKKRALVVVFPMFNILDVSGPVSVLFNTTDFSVSYAAKDELTTSQENTTIKRDISLAEAKLHLSDYDILIVPGSRPNNILPLVETDQGPLSELVEFITCFASDMDQDSMRQRTILAVCMGSYFLAFAGVLDGLTATTHRLAVPGLRDVTQRYVDRTPAAKGTRVVPEDPSDLVSYLDAGQNQAGVRIITTGAMANGIDATLHFVGLCSGRSLAIEVAELIGYRWKEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W6QC74</accession>
    <name>W6QC74_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alcohol dehydrogenase superfamily, zinc-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S03g000415</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QC74"/>
    <dbReference type="STRING" id="1365484.W6QC74"/>
    <dbReference type="OMA" id="DWEVDEI"/>
    <dbReference type="OrthoDB" id="3509362at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052585">
        <property type="entry name" value="Lipid_raft_assoc_Zn_ADH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43482">
        <property type="entry name" value="PROTEIN AST1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43482:SF1">
        <property type="entry name" value="PROTEIN AST1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="2">
        <location>
            <begin position="123"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="329"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="395"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="438"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM33691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="677" mass="72132" checksum="DFD9810156E09BFF" modified="2014-04-16" version="1">MYQDPNDTMQSDIPPTQPIVEHSPKHLSESSTRSPKDIKPPSEPSKRASGATRGTSEAIKPPSHAGKLSSSTLNDSPFIPLSMRALYFTPDGSDNDTPDGVPEGEISDAISPDTSTSVVRQKGTNIVFDAGFPTPQPSPQQYLLKIATAAFCHDEIRLARLLNPPKTTPHIPLHSLCGTVVSTPRDDEGREEGPKFKIGDVVFGVVSYTRDGGAADYAVATETELALKPDNITFAEAAALALPALTAWQALFRYAGLDPDLPGGLGEGDDEFANGTGRWLWQRQRRESVLGSRDYGYGRRKSSNSGLLNHTISGNGNESGNGHWVWQWNRGGSRTSASGSVSGNGNGSDIDNIPPAARAVNPAPSPTNVRRESLISLVSGNPSGKKTVARAASTVDPNPKSTVRRNSLISLITGNTDAPSSRAASTVDPTANPDANSKPRRGSSSPRRRSSLLGSIIGANSNGSGKPKPPIIRVLITNARDSDIGRIAVQILRADSLFPIAFRPWVCVTCTQVEADIIEKDWEVDEIVIIPHLPSPEECNIEKVFRTRRWEPVDIVLDCAGGEVFRAAHAAGVVKDHGAVLTVVDGQVALQSPLVPEKDVLGERKRGIKSRFVPVNPDGPALERIAELVEQSLVRGREVTIVDLSHAVDLLASGAAGTAGSRRGGMVVVRVNSVAFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W6QCG0</accession>
    <name>W6QCG0_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">guanylate kinase</fullName>
            <ecNumber evidence="2">2.7.4.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PROQFM164_S03g001097</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the guanylate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.8" evidence="2"/>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QCG0"/>
    <dbReference type="STRING" id="1365484.W6QCG0"/>
    <dbReference type="OMA" id="HFFEHVK"/>
    <dbReference type="OrthoDB" id="6334211at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004385">
        <property type="term" value="F:GMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00071">
        <property type="entry name" value="GMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.63.10:FF:000002">
        <property type="entry name" value="Guanylate kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.63.10">
        <property type="entry name" value="Guanylate Kinase phosphate binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008145">
        <property type="entry name" value="GK/Ca_channel_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008144">
        <property type="entry name" value="Guanylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017665">
        <property type="entry name" value="Guanylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020590">
        <property type="entry name" value="Guanylate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03263">
        <property type="entry name" value="guanyl_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23117:SF13">
        <property type="entry name" value="GUANYLATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23117">
        <property type="entry name" value="GUANYLATE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00625">
        <property type="entry name" value="Guanylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00072">
        <property type="entry name" value="GuKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00856">
        <property type="entry name" value="GUANYLATE_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50052">
        <property type="entry name" value="GUANYLATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Guanylate kinase-like" evidence="7">
        <location>
            <begin position="8"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM34373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="193" mass="21423" checksum="D296948B1BBFDFEB" modified="2014-04-16" version="1">MASSPQDRRPLIISGPSGAGKGTLIQKLIDTHPHTFELTVSHTTRQPRPGEKDGISYHFVSVETYNTLKHNGDLIEDAMYTGAFYGTSKAALAEILDKGLIPILDIEMTGVQQVKTSGFDARYVFVKPRDLGVLEERLRGRGTESERDIRARLDRARRELEFAETAGVFQRIIVNDDLGRAYAELEGFVFGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W6QCJ8</accession>
    <name>W6QCJ8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="13">U2 snRNP component prp10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">prp10</name>
        <name evidence="13" type="ORF">PROQFM164_S03g001147</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SF3B1 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the phosphatase 2A regulatory subunit A family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QCJ8"/>
    <dbReference type="STRING" id="1365484.W6QCJ8"/>
    <dbReference type="OMA" id="LVMNYVW"/>
    <dbReference type="OrthoDB" id="438939at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000066">
        <property type="entry name" value="Splicing factor 3B subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000069">
        <property type="entry name" value="Splicing factor 3B subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000810">
        <property type="entry name" value="Splicing factor 3B subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054573">
        <property type="entry name" value="PP2A/SF3B1-like_HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015016">
        <property type="entry name" value="SF3b_su1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038737">
        <property type="entry name" value="SF3b_su1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12097">
        <property type="entry name" value="SPLICING FACTOR 3B, SUBUNIT 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13513">
        <property type="entry name" value="HEAT_EZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22646">
        <property type="entry name" value="PPP2R1A-like_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08920">
        <property type="entry name" value="SF3b1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Splicing factor 3B subunit 1" evidence="11">
        <location>
            <begin position="218"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="9">
        <location>
            <begin position="588"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatase PP2A regulatory subunit A/Splicing factor 3B subunit 1-like HEAT repeat" evidence="12">
        <location>
            <begin position="995"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="16"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="130"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="183"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="183"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="231"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF22646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDM34423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="1209" mass="134297" checksum="80BD18DE730295DD" modified="2014-04-16" version="1">MSDADIEAVRRLQAERNAAAASKKGSKTFDQSAQRTDNSTKASLTESFDTFLYERDGAEKFSGYDTSIAVDVDEEMEDADGGHRLVGQYTATRGQIDEMAQGTGVEEEDILLGREKAARIADRETDYQKRRFNRGALTPTRADPFAANAHANVEGESQTYREVMAIREVEREEERVKQLIAEKLEKGEDVTEHQATLKLVEQDKENAEAGSTVAVATEKKRKNRWGDSSTEPEKRSRFDAPKEEPESMPSRWDLAPSLTAATPVGNQGLATPMHPSQAGAATPAVGFGVGMPGQVVGWSDEELDIMLPGEAQGYKVLDPPPGYEPIRTQSRRILATPAPISNAGVGGFMMQEPETVQSVGKDLPTDIPGVGELQFFKAEDMAYFGKLMEGGDETSMTVEEMKERKIMRLLLKIKNGTPPMRKTALRQITDNARDFGPGALFNQILPLLMERTLEDQERHLLVKVIDRILYKLDDLVRPYVHKILVVIEPLLIDQDYYARVEGREIISNLAKAAGLATMISTMRPDIDHADEYVRNTTARAFAVVASALSIPALLPFLRAVCRSKKSWQARHTGVKIVQHIPILMGCAILPHLKELVGCVSGNLSDEQAKVRTVTALSLASLAEAANPYGIESFDDILSPLWTGARKQRGKGLSAFLKAVGYIIPLMDEEYANYYTTQIMEILIREFASPDEEMKKVVLKVVSQCANTPGVTAGYLKEHVLTEFFKGFWMRRMALDRRNYRQVVDTTVDLGQKVGVGEILERVVNNLKDESEPYRKMTVETVEKLIASLGAADISERLEERLIDGVLFAFQEQSIEDLVILNGFGTVVNALGTRCKAYIPQIVSTILWRLNNKSPTVRQQAADLISRVALVMKQCDEEALMGKLGIVLYEYLGEEYPEVLGSILGALRAIVTVVGITQMQPPIRDLLPRLTPILRNRHEKVQENTIDLVGRIADRGPESVNAREWMRICFELMDMLKAHKKGIRRAANNTFGFIAKAIGPQDVLAALLGNLRVQERQSRVCTAVAIGIVAETCAPFTVLPALMNEYRVPDLNVQNGVLKSLSFLFEYIGEMGKDYVYAVTPLLEDALVDRDQVHRQTAASAVKHVALGVIGLGCEDAMVHLLNLLFPNIFETSPHVIDRVIEAIEAVRMAVGTGIVMNYVWAGLFHPARKVRMPYWRLYNDAYVQAADAMVPYYPDMEGDVERPELSIIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W6QCU8</accession>
    <name>W6QCU8_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">DNA replication regulator SLD2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">sld2</name>
        <name evidence="10" type="ORF">PROQFM164_S02g002170</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 8">Has a role in the initiation of DNA replication. Required at S-phase checkpoint.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the SLD2 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QCU8"/>
    <dbReference type="OMA" id="AVRMPQK"/>
    <dbReference type="OrthoDB" id="8775810at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902977">
        <property type="term" value="P:mitotic DNA replication preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22289">
        <property type="entry name" value="RecQL4_SLD2_NTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1460:FF:000001">
        <property type="entry name" value="DNA replication regulator Sld2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021110">
        <property type="entry name" value="DNA_rep_checkpnt_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040203">
        <property type="entry name" value="Sld2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28124">
        <property type="entry name" value="DNA REPLICATION REGULATOR SLD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28124:SF1">
        <property type="entry name" value="DNA REPLICATION REGULATOR SLD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11719">
        <property type="entry name" value="Drc1-Sld2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4 8" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="64"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="271"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="347"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="64"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="92"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="183"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="276"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="372"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="453"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="511"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDM32019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="554" mass="61119" checksum="82B86C38E04F70DF" modified="2014-04-16" version="1">MADNALTSSAEVGAQAVNVRAELKTWEKAFSSANRGRKAGRDDIKQNADIAAKYKEYSRLKALEASLSRRENSRQEGYESHSKKRKHASPPGQDSTSLQVTPRKSSRGLFATPSNNRTKHHPAQLDPYDSPSTLRRLFSPSTHRQGLPAPSPLKAAIGPTPQRDGKTLGLFDMLSESGGSGGTPSATRRTNNLAAAFRTPSKRKPVSTIPEAPEEEPQQETPRLARTPASETKQFYLANLFATPTTMRYAAMVEATDNADSQSTNLLNPAHEISPQEAQSGTPSFLRRSNSGRYPPLSAKHDGPGLSPIVSRKPQRFASKGLTHLVQGLRDMEEERMDDDWDVMREMEEEAEAEEAAKIQVEDSQGPDVNRKYKKKGQKRTTRRVIMRPVIHQPKPKPKPNPALANEDSEHEDDVVAVPETQQPPAASDGWDDVPSDIERADEAASLHTMSEPELDTEAEFDSDSNDDPEFAGQPKPVARPKSFSERIKEAVSSSSVKPQEQEPMGKPPKKPAETVEAKKPRPRKIKAEAHANYRSISINRGGSSRGRGRFRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W6QD30</accession>
    <name>W6QD30_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DNA replication checkpoint mediator, MRC1 domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PROQFM164_S02g002250</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1365484.W6QD30"/>
    <dbReference type="OMA" id="ERFNFRP"/>
    <dbReference type="OrthoDB" id="2130597at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010997">
        <property type="term" value="F:anaphase-promoting complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007095">
        <property type="term" value="P:mitotic G2 DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024146">
        <property type="entry name" value="Claspin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018564">
        <property type="entry name" value="Repl_chkpnt_MRC1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14396">
        <property type="entry name" value="CLASPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14396:SF10">
        <property type="entry name" value="CLASPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09444">
        <property type="entry name" value="MRC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA replication checkpoint mediator MRC1" evidence="5">
        <location>
            <begin position="868"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="295"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="531"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="696"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="766"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="878"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1017"/>
            <end position="1088"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1106"/>
            <end position="1156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1168"/>
            <end position="1284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="31"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="129"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="192"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="252"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="302"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="317"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="339"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="397"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="538"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="563"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="579"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="604"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="696"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="735"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="878"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1017"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1029"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1106"/>
            <end position="1127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1168"/>
            <end position="1182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1208"/>
            <end position="1220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1243"/>
            <end position="1254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF09444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDM32099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="1284" mass="141407" checksum="68FBD55CB28D2C26" modified="2014-04-16" version="1">MMAAFDSDSEDDTQIAKSTDAVSKLDLGRGLVRDANTRENDLLHDSDESASADEVFRPKGRMAARLQGNSRSAETEDGNSAFARVSKAFRSEKEQGEKPQQTEPQPTPIDESSDDDLPTAGPRRKHKSTTNSPRPDNRTSQTPSRSRADSPLFVSSPGEPHDDLHTENEDTENAEEKKPRGNARFLSLVAQKRKEREEREKADAETKKAIRKVQLEQFSSQIVSGEESGADDPRSASKLSQKARQPRKASKKALDEMKQETQRMSRNMQLAHQAKTKKKITKESLFAKFNFMQPDPPVEQLAANSSSAVGSQNSSDGELHNKTKDTPHTSPVLGHLDSTKSTANSGHAQTQAKDVDMDMDTDNEGLPDPNVLMAPNQYPELFEGPSVQDVSASVPESKSDGAESKRVFRPLTQRPIRVLLSRKEVAAHQNDVDDSDSDLEVITSPGKCRGIAAFENLPTRQAQEDPSMTKLKALAHLASPTRKMASMNSAELSANLLWRARQQAAKERQERLDELRAKGVVIETAEERAAMEDDMENLVEKARKEGDEIRRLEKAAMKKANGDDDEEEDDDYVLSGSDQEGDVEADDEDDQEEENERVNGGGDLVEEEADEDDDSADDESEVAPSDAENEMPALRRKRRTLVVSDDEDDDQPQAPSTPVRAPSFVPQSVERPNFLGMGTLGDMSLGLTQAFASTLDGNGVGTQEESATIPFSLPDPGQPVPQLRKEDSEVLVPDSQPQTQDNNFIESYTQSVTRVSESPAPYAFSEYSQSQLPDPTQDEGFVFSPFDPAKRFKATPPMSTIDTVLVGQTQSPIAERKRKMLRRGRASELVQVDENNNEGDFEIDANAFNVMKKDKAAKKNHVMQYDKKTSKAKDIIDEAAEESEDEYAGLGGHSDESDGEENAVDRQMINDNSGEVVDEKQLAALNAIHDRNRDEKDVAKLMRDITTGALRRRKNVDDDFDLDDSDDELLARRREKQREFAKMRRALLADEKIGEIADNPKKAAFFKAVEDREIDDDFNIDFLEEEENGSQTETPQVPVSGEQSNDATSDGQSRKRPLEPSAEDATNRLPPRLRRTPASAMSKKPATIAEIRETLSFLTETFEYDSFQDDASLDEAEHEQGDDETPGAEEAQGDHDQPQSDNTFIKPSHPRRTRGVVVDRLALLRQASSNSATSTNSGPTNSKLAFHSGSGGEGPIGFRPPQLLRRVTSGSSSSSSSTTSNRVTKPAASGPKKGGAVNSYTAAREREREKELRIKQRSGGSNIAKLLGKHTGGGLGALDKGQWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>W6QDC1</accession>
    <name>W6QDC1_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">T-complex protein 1 subunit delta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">cct4</name>
        <name evidence="11" type="ORF">PROQFM164_S02g002335</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM164</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QDC1"/>
    <dbReference type="STRING" id="1365484.W6QDC1"/>
    <dbReference type="OMA" id="HPAANMI"/>
    <dbReference type="OrthoDB" id="10248520at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03338">
        <property type="entry name" value="TCP1_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000010">
        <property type="entry name" value="T-complex protein 1 subunit delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012717">
        <property type="entry name" value="Chap_CCT_delta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054827">
        <property type="entry name" value="thermosome_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02342">
        <property type="entry name" value="chap_CCT_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041082">
        <property type="entry name" value="thermosome_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDM32184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="536" mass="57677" checksum="9725FC8545A461A5" modified="2014-04-16" version="1">MASVLAQGAGGNNSFKDKEKPMAVRASNILAARAVSDAIRTSLGPRGMDKMIQTAKGRTIITNDGNTMLKDMSVMHPAARMLVDLSAAQDVEAGDGTTSVVVIAGSLLGAAEKLLGKGLHPTVIAESFQRAAGAAVEILHNMSRPINLSDRSTLLQAASTSLSSKIVSQHSGLLGPMAVDSVLKVCDPKTAENVDLRDIRIVKKVGGTIEDSEMVDGVVLNQPVIKSSGGPTRIEKARIGLIQFQLSPPKPDMENQIVVNDYRQMDKILKEERQYMLNMVKKIQKTKCNVLLIQKSILRDAVNELSLHFLSRLKILAIKDIERDEVEFLCKSLGCKPVANVDSFTEDKLGSADLVEEVQSSGARYVKITGIKAPLSSYNQTVSIVARGANSLILDEAERSLHDALCVIRCLVKKRAMIAGGGAPEIEVAHLLAMRARELTGTEAICFKAFADAMEVIPTTLAENAGLNSIKVVTELRHRHAQGQHNAGVSIRSGGVKDDITEENILQPLLVSTSAIELAAETVKMIMRIDDIALSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2024-10-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W6QDC7</accession>
    <name>W6QDC7_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S02g002340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QDC7"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM32189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="56" mass="6334" checksum="5771ED33C2842903" modified="2014-04-16" version="1">MLPRCSVGLDPDDGVTLPHANPTTFTPQEYDLGRISNILCAYRYISDIYSSHLRLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W6QED7</accession>
    <name>W6QED7_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g001763</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QED7"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM27952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="51" mass="5774" checksum="2E50C6DD67E27C1D" modified="2014-04-16" version="1">MHFISPDQPRLAQTRKTAFSATSDPAHQHESMTVANFPFVQYFPIGDTVRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W6QEL6</accession>
    <name>W6QEL6_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid/polyamine transporter I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PROQFM164_S01g001838</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QEL6"/>
    <dbReference type="STRING" id="1365484.W6QEL6"/>
    <dbReference type="OMA" id="NTIIHYW"/>
    <dbReference type="OrthoDB" id="10062876at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF15">
        <property type="entry name" value="GENERAL AMINO ACID PERMEASE AGP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="27"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="278"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="312"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="354"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="384"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="6">
        <location>
            <begin position="1"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM28027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="454" mass="50275" checksum="7CBFDF15C82FF786" modified="2014-04-16" version="1">MVTYLPISSPFIRFAGRYVDEALGVAAGYNFFIFEAALVPFEIVAVSMIIKYWTDAIPVAAMNVVVIVLYGVLNLFAVKWYGEAEFWLSLGKVLLSTGLILYTFIVMLGGNPLGDRFGFRYWNEPGAFNGYYKTGDTGKFLGVLAAVITASFTIAGPDYVSMAAGETVNPRKVLPKAFNGVFYRLTAFFVLGVLSVGILVPYNDKTMADAFDNGKPGAAASPYVISMDRLKIPILPDIVNAVILTASFSAGNSYMYCASRSLYGLAIEGKAPRFLTKCTNNGVPIYCVGIVLVIGLLSFLQVSNSAAVVLDWFVNLVTASQLINFSVVTFTFIRFKKALDAQGIPRETLPYRSWFQPYIAYFACACTTVMAFVGGYTVFLPGNWSIATFFFSYTMIGVFPVIYFGWKFFHKTKLLKPEEVDLVTGVAEIEDYTRDFVVIPPKNIVYKWFQIIFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W6QEU3</accession>
    <name>W6QEU3_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ribosomal protein L23/L25, N-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PROQFM164_S01g001913</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL23 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QEU3"/>
    <dbReference type="STRING" id="1365484.W6QEU3"/>
    <dbReference type="OMA" id="RLDHHKV"/>
    <dbReference type="OrthoDB" id="1267328at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000035">
        <property type="entry name" value="60S ribosomal protein L23a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01369_A">
        <property type="entry name" value="Ribosomal_uL23_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013025">
        <property type="entry name" value="Ribosomal_uL23-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_uL23/eL15/eS24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005633">
        <property type="entry name" value="Ribosomal_uL23_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11620">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L23A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00276">
        <property type="entry name" value="Ribosomal_L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03939">
        <property type="entry name" value="Ribosomal_L23eN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="Ribosomal proteins S24e, L23 and L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL23 N-terminal" evidence="7">
        <location>
            <begin position="10"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="11"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM28102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="149" mass="16391" checksum="9874465AEDD0AF4D" modified="2014-04-16" version="1">MAPSDNKTGKNKANAAAKAVAKGASLHKSRKVRTSASFHRPKTLQLSRSPKYPRVSVNHGPALDFNKIVLYPLNTESAMKKIEENNTLVFIVNVKSNKRQIKQALKKLYDVDTVKINTLIRPDGTKKAFARLTPDVDALDIAATKLAIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W6QF64</accession>
    <name>W6QF64_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S02g002895</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QF64"/>
    <dbReference type="STRING" id="1365484.W6QF64"/>
    <dbReference type="OMA" id="HICISSA"/>
    <dbReference type="OrthoDB" id="5244761at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM32744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="125" mass="14367" checksum="CEE7D6FC27A044AF" modified="2014-04-16" version="1">MDESDPPVNEINAARIYTKYYSARYSRRSDQLEFNGITCSTLATISTNWQLPEVRLYKLPKKLKSVYHICISSAIKSTEAFDRVGGYRQFSNILVLSVSFILGLKELIELEQLKRLLVRTIGFLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W6QFW9</accession>
    <name>W6QFW9_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Probable electron transfer flavoprotein subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">etfa</name>
        <name evidence="12" type="ORF">PROQFM164_S04g000599</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 9">The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9 10">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="9 10">Binds 1 FAD per dimer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 9">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the ETF alpha-subunit/FixB family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QFW9"/>
    <dbReference type="STRING" id="1365484.W6QFW9"/>
    <dbReference type="OMA" id="WRPYAEQ"/>
    <dbReference type="OrthoDB" id="1715808at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01715">
        <property type="entry name" value="ETF_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000041">
        <property type="entry name" value="Electron transfer flavoprotein alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1220:FF:000001">
        <property type="entry name" value="Electron transfer flavoprotein, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014730">
        <property type="entry name" value="ETF_a/b_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001308">
        <property type="entry name" value="ETF_a/FixB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033947">
        <property type="entry name" value="ETF_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014731">
        <property type="entry name" value="ETF_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43153">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43153:SF1">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01012">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00766">
        <property type="entry name" value="ETF_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000089">
        <property type="entry name" value="Electra_flavoP_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00893">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6 9 10" id="KW-0274">FAD</keyword>
    <keyword evidence="5 9" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Electron transfer flavoprotein alpha/beta-subunit N-terminal" evidence="11">
        <location>
            <begin position="37"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="265"/>
            <end position="266"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="279"/>
            <end position="283"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="296"/>
            <end position="303"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="317"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR000089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000089-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDM35718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="350" mass="36469" checksum="7BFB77102F2568BF" modified="2014-04-16" version="1">MIPIARHSVLRAARAQLQPTRKLSLPTSSALARLLSTLAVLEQRNGKLESSSFSAVAAALKLGGSVTGFVAGSGVKATSAAEAAKIKGVEKVLAVDNDAYEKGLAENYASLLVENIKKGEFTHVIAGHSAFGKSVLPRVAALLDVQQISDITGIESEDTFVRPIYAGNAILTVQSTDKIKVITVRGTAFQDVEVEGGSAEVVDGVDPNVPALTEWVSEELAKSERPELATATRVVSGGRGLKSKEEFDRLMLPLADSLGAAVGASRAAVDSGFADNSLQVGQTGKNVAPQLYLCAGISGAIQHLAGMKDSKVIAAINKDPEAPIFQVADVGLVGDLFDKVPELTEKLKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>W6QG11</accession>
    <name>W6QG11_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Zn(2)-C6 fungal-type DNA-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PROQFM164_S04g000619</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QG11"/>
    <dbReference type="OMA" id="SALMYID"/>
    <dbReference type="OrthoDB" id="189997at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14653">
        <property type="entry name" value="ZIP_Gal4p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052202">
        <property type="entry name" value="Yeast_MetPath_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782:SF12">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="24"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="116"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDM35738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="671" mass="75214" checksum="9B04340B319032B8" modified="2014-04-16" version="1">MFQPGHNKRQSSRGTPSGSRTPLACVKCKEKKLKCDNRVSGCINCLRAGSVCLVEDPVTRAYRPRNYIETLEKRVAFLESLLRQCRPDLANNDPLRQYTLPPEVQPNSVPLAQHIETPDQRHGDQSTSSRAKSDVEEDDGVDKLSSKVGLLSLNAAGAEPQYLGSSSIFAFSRLINSSLRQVVSSDFPTANVLDWTENRSSVLPSPCLLPAYESAVKLSDIYFQNVNTHYPFLHEPTFRAWESMLLNESTELGILLPNSVSLFFLNMVYAVGALLLPSLGFSAERLYTSALMYIDDILAYDNLEAIQAILCCAIYSLRSSTGTSHWKLAGLALRQCIDLGYHRNTKHLAAPKDLLQVELRKRVFWCAYVIETQAAVMLGRPLGIPYQEVDVEYPIDIDDSCINETGLVGTPRSSPTDAPTNMTRAIHTFRIRRLLNRIHTYIYSKADPRYSRKHDQQTDVKNIRAEIEKWRSEIPPTAFHPGEELVLFTTADWYDLEYNYTILQLYRAQIVDHRVETTDEVFLDCLGAAENICRSYRHHFLGKPTRCTWAALHELFLAGLTYLHCLWTSPAARQAAGHGQASSTCNDCTIALVVMAERWDVAAPFREIFVALASRTMLMMSVKADENVSKNVASADSGNWAEEDLTEWMRIVADAGVLEGFNGLLTGLPSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W6QGN4</accession>
    <name>W6QGN4_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glutamate pyruvate transaminase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Glutamic--alanine transaminase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Glutamic--pyruvic transaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">ALT1</name>
        <name evidence="11" type="ORF">PROQFM164_S04g000017</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM164</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. Alanine aminotransferase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QGN4"/>
    <dbReference type="STRING" id="1365484.W6QGN4"/>
    <dbReference type="OMA" id="FGFECPP"/>
    <dbReference type="OrthoDB" id="1732682at2759"/>
    <dbReference type="UniPathway" id="UPA00528">
        <property type="reaction ID" value="UER00586"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042853">
        <property type="term" value="P:L-alanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.1970:FF:000001">
        <property type="entry name" value="Alanine aminotransferase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000012">
        <property type="entry name" value="alanine aminotransferase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000010">
        <property type="entry name" value="Alanine aminotransferase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045088">
        <property type="entry name" value="ALAT1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11751">
        <property type="entry name" value="ALANINE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11751:SF29">
        <property type="entry name" value="ALANINE TRANSAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="10">
        <location>
            <begin position="163"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00077894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00078532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00080525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDM35136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="544" mass="59890" checksum="DB04E577648B9B46" modified="2014-04-16" version="1">MSWQYKLASSVRAFPLRAQTSRPHNGLLYRPAARAAVGGVSASSESIMTQTASYSAQRNLSTPTPKCLNVDNINQNVRDAKYAVRGELAVKAETYRQRLIDGDKSLPFDSVIFANIGNPQQLDQVPITFFRQVLSLVENPLLLENAEVLKKSFGYKQDVIDRAQVLLANVQSVGAYSHSQGAAGIRDSVAKFIEKRDGFPANPQDLFLTSGASSGVNTILNVICNTPSTGILVPIPQYPLYTATLTLLNARCVPYLLDEEKAWGTDVNTILKSIEDAKAAKTDVRAVVVINPGNPTGASLSAEDIKNVLDVAAEESLVVIADEVYQTNVFKGEFISFKKRLRELQQEQPGKYDNIELVSLHSISKGMVGECGHRGGYFELAGFDPLVQEQIYKLVSIGLCPPVTAQCLLECMVNPPIEGDPSFELYQQEYTDISEGLRKRAFSLYNAFQRMEGVHLQEPQGAMYLFPSIHLPAKAIEAAKAEGRPADEFYCLALLDATGVCVVPGSGFGQKENTFHFRTTFLAPGTDWVERIVKFHAEFMDKYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W6QGQ3</accession>
    <name>W6QGQ3_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S04</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S04g000889</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM36008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QGQ3"/>
    <dbReference type="STRING" id="1365484.W6QGQ3"/>
    <dbReference type="OMA" id="GLQIGRW"/>
    <dbReference type="OrthoDB" id="3886018at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM36008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="438" mass="47750" checksum="421BF6DD231EA04D" modified="2014-04-16" version="1">MLYTTTVGEKHPLSKTQMQQYRPAWTCRWSSFQMASIRMMLKPLASDTNSTVSTTTCLPSTTATTIEYSVAGSATTFSSTSTSDTPVLCPPDTCEKLSSMRTSLLGSASMGVAAMIEHYESIPTDITTILPAEGCEIATTSGAASPTRPVSKTTLSSSQDEKMMISSLIAYASQDASPPYSSYVKSLAPIWIDQPGPVSAQWFNYPSIGHSAVGVKGIYGCTVVIIASEKGVYLSHIWESPVFVDLAFNPTDDDSFTMNASKSLRDGTLYAQSITALIGTDHNPGVLNAIYAPKVFVLTPFTTDWDRQYFGISTKFRYQKRAQELAQKIANIVPGSGGNGIILGYTRTSRQASSQEQGIAGRTILEIDPSYTRLTSIHDSSSAGLQIGRWRLWVEDQLITYQDFWLPHITAPRDTSRYAIGQETLVMPTRVGATLRYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W6QGT2</accession>
    <name>W6QGT2_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Genomic scaffold, ProqFM164S04</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S04g000919</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM36038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QGT2"/>
    <dbReference type="STRING" id="1365484.W6QGT2"/>
    <dbReference type="OMA" id="SDWFQGK"/>
    <dbReference type="OrthoDB" id="5377009at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="107"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="292"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="184"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="129"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM36038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="447" mass="49085" checksum="493B5136A840D639" modified="2014-04-16" version="1">MSPDLTHAPVTLHSDGTHPHETVALTLPRSSVPRTARNQLNNPPSHRRANTEYIARPPLFEQGIDGTISNPKNTPWSETFPKKKLEARARVLSDWFQGKSDPVELGLNMGPGASDGTGLDSRPAASMSHMRQNSTSTNRFSFFGLRRQPSKPNFPEPADDEFLNLDITAALRLPETDDTNDEALDSLRDHADKVLRRMQEAYKQRTFAMHQALADKNEKQEELEETRARVDHLKMQLDGMAAKVLDQEKAMKAMAEELEEEREMRKTEESRHRSRAIRTVYPDDDAASMALQTPRRGGKRASHSTFTSDSGFESGDESIAESIFSLREGVESPTSALTAPSPNMSQIALSTPTVPTPAQKNLVAATSTPPPVRSAYDRVLKGLASTRLGSSFAGGNSNAPNCTNCYGVPASEAWSVMGVLQEENRGLKNRLGELEVIIDDCLGLVGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W6QGZ6</accession>
    <name>W6QGZ6_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Solute carrier family 40 member</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PROQFM164_S01g002693</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">May be involved in iron transport and iron homeostasis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the ferroportin (FP) (TC 2.A.100) family. SLC40A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QGZ6"/>
    <dbReference type="STRING" id="1365484.W6QGZ6"/>
    <dbReference type="OMA" id="YPVFISY"/>
    <dbReference type="OrthoDB" id="648861at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005381">
        <property type="term" value="F:iron ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd17480">
        <property type="entry name" value="MFS_SLC40A1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009716">
        <property type="entry name" value="Ferroportin-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11660">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 40 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11660:SF57">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 40 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06963">
        <property type="entry name" value="FPN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="67"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="202"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="286"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="352"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="447"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="12"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM28882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="496" mass="54159" checksum="5920CAE23B5D7254" modified="2014-04-16" version="1">MVLGSEFPEPSRQPSEDISNSSNPLLPTLADDGPPQNDSPAPEAHSVLTRLYISHTLSTWNSRMFEFGAVLFLASIFPGTLLYASIYALVRAFSAVALSSWLGAQVDRSDRLVAVRHSIVWQRVPVAISCLCFVATLSTDSWSLTIALFTVQGLLACMEKLAATANTVAVERDWAIVISESINVPRQDLNASMRRIDLFCKLLAPVFISLIDSISTPYAIWTVFTMNTASVLVEYLAIAQVYQSVPALTKTQAPTTQADDTNGKSDTRCLSSSLAPWKEYIASPVFLASFALSLLYLTVLSFGATMVTYLLHTGFTPLEVSYMRIGSVVAELSGTWTAPMVMNRIGPIRSGLWFLNWQFICIAAATVAFVFWDPSSQFVAGALITGVALSRIGLWGFDLSVQFLVQENIQEHARARFSATEMALQNVFEMLSFASTIAFPLPAQFRYPVMISSGAVAVAAVCFATYVRKERGHLLHRSRCMGGDKVSYRAIGSGSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>W6QH16</accession>
    <name>W6QH16_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribosome biogenesis protein RLP24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">RLP24</name>
        <name evidence="6" type="ORF">PROQFM164_S03g000213</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL24 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QH16"/>
    <dbReference type="STRING" id="1365484.W6QH16"/>
    <dbReference type="OMA" id="TCYFCSG"/>
    <dbReference type="OrthoDB" id="10262490at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902626">
        <property type="term" value="P:assembly of large subunit precursor of preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00472">
        <property type="entry name" value="Ribosomal_L24e_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.170.20:FF:000001">
        <property type="entry name" value="probable ribosome biogenesis protein RLP24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.170.20">
        <property type="entry name" value="Ribosomal protein L24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038630">
        <property type="entry name" value="L24e/L24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056366">
        <property type="entry name" value="Ribosomal_eL24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000988">
        <property type="entry name" value="Ribosomal_eL24-rel_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011017">
        <property type="entry name" value="TRASH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10792">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10792:SF8">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN RLP24-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01246">
        <property type="entry name" value="Ribosomal_L24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00746">
        <property type="entry name" value="TRASH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="TRASH" evidence="5">
        <location>
            <begin position="6"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="150"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDM33489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="190" mass="22510" checksum="A4596D15A3448363" modified="2014-04-16" version="1">MRVETCHFCSRPAFPSKGITFVRNDARQFRFCRSKCHKNFKMKRQPRKLKWTKTHRASRGKEMIVDSSLVLSQFAKKRNVPVKYDRNLMAATITAMERVEEIRARRERVFTKRRLAGKTSRERQREADRKVVNEGEHLIRKELREREEGLPMVAEQSKVSNRVHGEERVRQKQKSKLLVDGGVEEQMDID</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W6QHI7</accession>
    <name>W6QHI7_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribosomal protein L19</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S04g000776</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL19 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QHI7"/>
    <dbReference type="STRING" id="1365484.W6QHI7"/>
    <dbReference type="OMA" id="VCLNIRQ"/>
    <dbReference type="OrthoDB" id="432645at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001857">
        <property type="entry name" value="Ribosomal_bL19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038657">
        <property type="entry name" value="Ribosomal_bL19_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15680:SF9">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL19M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15680">
        <property type="entry name" value="RIBOSOMAL PROTEIN L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01245">
        <property type="entry name" value="Ribosomal_L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM35895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="224" mass="25723" checksum="E5BCC4EE89B44409" modified="2014-04-16" version="1">MAALPAMRPLGCLRSLLRASEPVQPFINRRFISTAYSKRPERVPLPPNMPEQFLSQIPLRFRPDPEREPLKIYPAPPSARKACKDPIAAVTESQLAVLDPTGERKAMFDYRRNPRSVKTGDIVRVTFKNGDPFNGIVLSIKLRGIETSFLLRNELTRVAVEMSIKVFSPNVNSVEIVQRSEKKRRRARLYFLRDRKHDRRSVENVVANYVRQKKAFLGGGNRRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W6QI79</accession>
    <name>W6QI79_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">UBA-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S01g003084</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QI79"/>
    <dbReference type="STRING" id="1365484.W6QI79"/>
    <dbReference type="OMA" id="WAMTLFN"/>
    <dbReference type="OrthoDB" id="4489171at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14273">
        <property type="entry name" value="UBA_TAP-C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055335">
        <property type="entry name" value="Ucp6/RUP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39597">
        <property type="entry name" value="UBA DOMAIN-CONTAINING PROTEIN RUP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39597:SF1">
        <property type="entry name" value="UBA DOMAIN-CONTAINING PROTEIN RUP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14555">
        <property type="entry name" value="UBA_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="46"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="697"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="736"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="505"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="47"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="75"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="712"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="739"/>
            <end position="752"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM29272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="793" mass="88691" checksum="FFCB55ADB8966823" modified="2014-04-16" version="1">MASEPTEEAITSFVSFTSTTREQAIAFLKANNLDSQKAINAYFEDPTGSQLQPITSYWNDNGGSSWDFAQQDNAPPMPPTAPPTRPPSRVDIRDSEQNAGYQDSVAIAPKEGSGHGLSLAEREEKELQQAVAMSLNSDMGQQETGVTSHRQPQFNKATRDHYEEGAWAMTLFNTSSEEVMISPDPEDRKRVEGEPAFIRPNTDGLYLGGLLTILHSIPLAREALLLRNKPLFDYGHEPQWWNGQPINLPKIVTVNDGKTGDSDWDDIIHETQRLMAFMDTTKRAFGSSDSLAKINSMSSLSADSEEIVTRFLEAWHGAAIQADPENPLTTIFTTYAYKRETFDEFVEPITRELFTFEPPVEQDNDQTLYDVLDSALWSDRPGKEFDDTWLEHLADVLVIRLDALQKPNAVGVDIHSVFYPDRYLSSCRDLSREFRAKRQQIQGDVLKLEQLIHRYTIPRDPVGNSTITELLEQAAQAVPVVTPEQVGESDQSDSGAAGAETMRVAEELRAIATNIEAKLKELEIRKQSAMESLREISKTLIEPPKSPSEPPFHKYTLRGVCTEPHVTYVLSSPRTTTPGHLMDMDSETENNNDYQWWRISFSGEDGKTRQAEKRKAQGNTAATQDSEVVGYTVRKVQEIEVLQAAREEWSSVLLVYASENAVNSKVDPAPSQLQGFVNRDNDAYGGEFENTPTIIFSDQEDPWAEPNNVETQPKEQQPEMSEKSTKVNVFDYEVSAFDDEPKPSQEMQEKDGASLLGHPATANNSTAFTASQVDLAWNSADDEEMANHLKHAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W6QJ67</accession>
    <name>W6QJ67_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S05g000671</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QJ67"/>
    <dbReference type="STRING" id="1365484.W6QJ67"/>
    <dbReference type="OMA" id="VERYWQK"/>
    <dbReference type="OrthoDB" id="4485682at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM36838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="58" mass="6976" checksum="473FD87773C98744" modified="2014-04-16" version="1">MLRLPSSPTDPILCEETRARLEHFRSLRWLPLNFKLKTLEGIAVVERYWQKYCIQSNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W6QJD6</accession>
    <name>W6QJD6_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Galactose-binding domain-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S03g001028</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CIA30 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QJD6"/>
    <dbReference type="STRING" id="1365484.W6QJD6"/>
    <dbReference type="OMA" id="IMVRSFF"/>
    <dbReference type="OrthoDB" id="426386at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010257">
        <property type="term" value="P:NADH dehydrogenase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013857">
        <property type="entry name" value="NADH-UbQ_OxRdtase-assoc_prot30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039131">
        <property type="entry name" value="NDUFAF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13194">
        <property type="entry name" value="COMPLEX I INTERMEDIATE-ASSOCIATED PROTEIN 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13194:SF19">
        <property type="entry name" value="NAD(P)-BINDING ROSSMANN-FOLD SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08547">
        <property type="entry name" value="CIA30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:ubiquinone oxidoreductase intermediate-associated protein 30" evidence="3">
        <location>
            <begin position="13"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="190"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="196"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM34304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="223" mass="25346" checksum="8892574C749E9D87" modified="2014-04-16" version="1">MEYPTNNQIIFGPDWDLSRWTSSDDRVRGGSSVSNLDPTPEGVLFHGNLDIETLGGAGFASQRTIGDEQVWDLTGHDGVELHVGPSDRKRYTFSLTDEIPQQRPDGREQSALVWEYDFCESETGREVRISWKDLKPTYRGKPVEDARPLDLSCIKRFRIMIRSFFGAQQGDFSLKIQSIGLFRQSYLDDPSVPKDSMGHGDDKTGPEETEEKKSWFRSCCPLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W6QJX4</accession>
    <name>W6QJX4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S05g000553</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QJX4"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM36720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="65" mass="7602" checksum="47269F4201182541" modified="2014-04-16" version="1">MKRENKTGNCMQKSLTRCRYLPFDVFIYLLAPLPCHCKCIFISCIWCYNGMYQTMPGTRDLSPSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W6QK57</accession>
    <name>W6QK57_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PROQFM164_S02g000111</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM29962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QK57"/>
    <dbReference type="STRING" id="1365484.W6QK57"/>
    <dbReference type="OMA" id="GNVGCAK"/>
    <dbReference type="OrthoDB" id="2533084at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000318">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF2">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G08910)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="111"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="139"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="201"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="227"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="296"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="337"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="377"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="467"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="73"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM29962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="500" mass="55630" checksum="6FBCC7A6D9A35FB8" modified="2014-04-16" version="1">MDRRHHYIKGANTREGDESGKPCAFYVEDPVAHLSEEHRQYLLSKHGTLDLEPIPDMTDTDPYNWPRWRKNFNLTLVAFHAMMATFTASSIQSAFENISEDLDVSMQRTSYLVSLFIAVLGGAPLFWRPLCNRYGRRPIFLISLICSLIGNIGCAKSTSYATMGLSRAITAFFISPAAAIGSAVVAETFFRKDRARCMGGWTLMVTLGVPSAPFIFGFVASRVGYRWIYYILAIVNATQFLLYFFFGSESLYVRGNIPTNTVIAAKQSLFKFRRIDPTPLEFWDFFQPLSYVMKPCVVIPAVAYAMIFLWGSVMLTIEISQIYPAKFGLNTQQVGLQFLGIIIGSVIGEQIGGFISDRWMLMRQKRTGEPSPPEYRLWLSYIGHALTICGIVVFAIEIRDSGGVWNIAPVIGAAIAAGGNQIVTTVDITYAVDCYREDAASVGVFITLVRQTWGFIGPFWFPEMFEVVGWAGGAGIAVALVVGVSVIPTVLVQWRGASWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W6QKD0</accession>
    <name>W6QKD0_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Kinetochore protein SPC25</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">spc25</name>
        <name evidence="14" type="ORF">PROQFM164_S02g000186</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 11">Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the NDC80 complex, which consists of NDC80, NUF2, SPC24 and SPC25.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Chromosome</location>
            <location evidence="11">Centromere</location>
            <location evidence="11">Kinetochore</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the SPC25 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QKD0"/>
    <dbReference type="STRING" id="1365484.W6QKD0"/>
    <dbReference type="OMA" id="HEDQRMK"/>
    <dbReference type="OrthoDB" id="4056921at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031262">
        <property type="term" value="C:Ndc80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23784">
        <property type="entry name" value="RWD_Spc25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.457.50:FF:000001">
        <property type="entry name" value="Probable kinetochore protein spc25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.457.50">
        <property type="entry name" value="Chromosome segregation protein Spc25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045143">
        <property type="entry name" value="Spc25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013255">
        <property type="entry name" value="Spc25_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14281:SF0">
        <property type="entry name" value="KINETOCHORE PROTEIN SPC25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14281">
        <property type="entry name" value="KINETOCHORE PROTEIN SPC25-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08234">
        <property type="entry name" value="Spindle_Spc25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5 11" id="KW-0132">Cell division</keyword>
    <keyword evidence="10 11" id="KW-0137">Centromere</keyword>
    <keyword evidence="4 11" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 11" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="6 11" id="KW-0498">Mitosis</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromosome segregation protein Spc25 C-terminal" evidence="13">
        <location>
            <begin position="183"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDM30037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="258" mass="30128" checksum="341DABE05D41794B" modified="2014-04-16" version="1">MASSFEPSLSTSGMRPPLASADAPSMADSLPSINFGFEDLRNTMAQFTVKFDAFIERGRKRVLEERNQFHINMAEYEEDERMRQRDIEILNLKSQTHEQTLQKEAAEAAEMHAAISSITLERDARLTKRDRLKQQIAETQKAISQKIEAQKSHAQYLDAQSRLNFPELEFWQDYLCIRIEGAGREDRLKFVYSHLLEKDWEAEAWFELGTASRDYEVFHTRPKVDRDALEHVVDLMNDDRDFGAFLKRMRKLFVEAMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W6QKG4</accession>
    <name>W6QKG4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S06g000239</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792020">
        <property type="protein sequence ID" value="CDM37278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QKG4"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM37278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="42" mass="4857" checksum="5BD7B2553B020F8E" modified="2014-04-16" version="1">MSKTFPESPQLAAYMGLLYGYEDSEPSERPNHRRHAVQNIHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W6QKV5</accession>
    <name>W6QKV5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S03</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S03g001521</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QKV5"/>
    <dbReference type="STRING" id="1365484.W6QKV5"/>
    <dbReference type="OMA" id="ERMFFQF"/>
    <dbReference type="OrthoDB" id="4177740at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="341"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM34794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="360" mass="40688" checksum="2B738566A039E6BD" modified="2014-04-16" version="1">MPPDFSTLRHRERQRAAAYLQARSEVIAAIDAIYKRVEIYSSAQINPTSYKSLGIDYRLLELDDDGKHLQPPNSDLSTPIFFEPRGATWVAPVRITDVECEGDLRAITDGWENVKDNPLVQSFHAQVWYVYLGLERMFFQFRREFYPEGDSRVPPNLRQISKWLKSGTIVPSVFAERFYSAIWGSMRWAPASAFVPKKLLYPGKPHTLIIILIQEEPSEELSRAEMMTLTAAMITRLEGEECLEYNTIPVMAITIFGRMKARVLEAHSSQQELVVKKTQLLDFSTNQVANKSMNILLGFMAGDLVGDPRGPTVPTDISKTSRTAEKVNTAKGGTIRKMFRKMRPRVVAGTEPEPSEGATQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W6QL13</accession>
    <name>W6QL13_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PROQFM164_S05g000524</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QL13"/>
    <dbReference type="STRING" id="1365484.W6QL13"/>
    <dbReference type="OMA" id="PHELIAF"/>
    <dbReference type="OrthoDB" id="5378633at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF108">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="31"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM36691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="109" mass="12177" checksum="ACCB852F672EC169" modified="2014-04-16" version="1">MTVENPTDVLHTVNLVTQCLCIPIVTIFVILRFYTRFRFKHPLGVEDLACTIAWLLFMGYCAISIVVGQHGGGYELSDISPHELIAFKKFCYIATILYCPMASSSKSPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>W6QL89</accession>
    <name>W6QL89_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type DNA-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PROQFM164_S06g000575</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792020">
        <property type="protein sequence ID" value="CDM37613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QL89"/>
    <dbReference type="STRING" id="1365484.W6QL89"/>
    <dbReference type="OMA" id="HPITFWG"/>
    <dbReference type="OrthoDB" id="271595at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050797">
        <property type="entry name" value="Carb_Metab_Trans_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668:SF30">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="24"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="79"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM37613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="682" mass="75781" checksum="ACADF202022194EE" modified="2014-04-16" version="1">MEIRSPGSATGPIRSHKSPIAKRACDQCKFRKIKCSLSQPCKACESMGFDCTFLQPQKKRGPTGHRVSQIRQQQTVIPTQESKNGFQFQAPSSSVESGQALPRAPWGAPTHGPATMPLEGAGLAPAGIPPPMAAWGEETPSIDSHNSGLSWNDRNDVEYWLPDNLDAQVPIFDLPGSNVYLRPSLPSIIQPVPDAAAAAIGIPQEGPNMAFSPTVRSMRSDTQETDAIWPSTINEANIIPWIDVYFDRLHPTIPVLNRSSLYTSMITQEHRKNSQFGAMLLSLCAFSLTQPIEINERPTSSSRALQARAMMNAATKMRSCSDFGENPTIEAVLTSFFLFGCLFGSNQHNAAWLRIREALDLAATLGLNDPESYQDLSGEEKGQRLRTYLVLSITERAYALQRRHPITFWGKPGFTMRSVHDFIHSATHSVVSGIVVHNEKDAEGMMGLARMMELFDAIDEDVIDCWNRRCDGSNGYCQRLTAVKALSIHQNLNRVNQAERYRGYDWFERAKEGRESRNVTFAMGLRETQAADVFITQKWLQNRVWLLSSTHGLLSAHSEQPELSFGYAVSVAESTLRLCQSLRLSSMEAHGIGLTEKLYDIAICATNILCNTNPSYGIGLNMPVNFPEIIPTTTTSTAQSLAEDFLLLMTSFRGGNHPYLEKYRAHLRSLQIMEPKAPEWAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W6QLP8</accession>
    <name>W6QLP8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Berberine/berberine-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PROQFM164_S06g000321</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792020">
        <property type="protein sequence ID" value="CDM37360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QLP8"/>
    <dbReference type="STRING" id="1365484.W6QLP8"/>
    <dbReference type="OMA" id="VNRYQFG"/>
    <dbReference type="OrthoDB" id="9983560at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF39">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005716482" evidence="6">
        <location>
            <begin position="23"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="7">
        <location>
            <begin position="107"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM37360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="559" mass="60097" checksum="3EA95936C658A612" modified="2014-04-16" version="1">MKWTLPSLVAIAAPAIASNCHCLPSDSCWPAPSAWASLNHTVGGRLVATVPIGTPCHAPNYDAAACAALKTDWNKPQTHLESSSSVMQMFFANQSCDPYTSKNKPCRLGNYVNYAVNVSSSAQVIAAVNFARDNNIRFVIRNTGHDYLGRSTGAGALSVWTHHLNDIEYQDWSGPTYTGPAFKIEAGVVGYQILEAAAAKGLVVVGGECPTVGLAGGYTQGGGHSALSSNFGLGADNTLEFEVVTAAGDLVKASRTENPDLFWALSGGGAGNYGVVISLVVKAYQDASIAGAALEFTAADITTDTFYEAVSQFHALLPAMVDHGVTVIYQMTKSVFIIDPITAYNQTTDDVKAILEPFTSKLTELNITYQASFTEHDSYYDHYNTYMGPLPWGNLDVGAYQYGGRLIPRSTLEQNYNGMGDALRTLTQGGLVAVGVGMNVSNPVNVSNAVFPALRNAAVTMQFGLPWNETAPWSEMIADQKKITTKYVPALEAVTPDSGCYQNEADFRQPNWQQTFFGSNYAPLLTIKRKWDPASFFYALKAVGSDAWSVSDSGRMCRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>W6QLX9</accession>
    <name>W6QLX9_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">chitinase</fullName>
            <ecNumber evidence="4">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PROQFM164_S02g000716</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 18 family. Chitinase class V subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="4"/>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QLX9"/>
    <dbReference type="STRING" id="1365484.W6QLX9"/>
    <dbReference type="OMA" id="SYPESKY"/>
    <dbReference type="OrthoDB" id="76388at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06548">
        <property type="entry name" value="GH18_chitinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.10:FF:000005">
        <property type="entry name" value="Endochitinase B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000095">
        <property type="entry name" value="Endochitinase B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF365">
        <property type="entry name" value="ENDOCHITINASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="Chitinase insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 12 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="GH18" evidence="13">
        <location>
            <begin position="4"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDM30567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="399" mass="44101" checksum="CB97B00F0F4644A3" modified="2014-04-16" version="1">MCEMRSVAYFVNWAIYGRNYNPQDLPAEKLTHILYAFANIRPESGEVYLTDSWSDVEKHYPTDSWNDVGTNVYGCVKQLFLLKKQNRKLKVLLSIGGWTYSSNFAQPASSHEGRTAFAESATRLVLDLGFDGLDIDWEYPKDDTEAEHLVLLLRKCREVLDREAGPDRRFYLSIACPAGPSNYEKLRFQDMTPVLDFYNLMAYDFAGSWDSNAGHQANIVPSVSNPASTPFSINTALDYYINVGGVPPSNIVMGMPLYGRAFENTDGPGAPFSGVGEGSWENGVWDYKALPRPGAQEQFDQEPGASFCYDAGARKMVTYDTPYMAQIKANYIRERGLGGGMWWESSGDKGGKEADPAQGSLIGIFVDGVGGPGALDQSCNALDFPESKYANVQAGFPEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>W6QMC7</accession>
    <name>W6QMC7_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Mitochondrial phosphate carrier protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">PIC2</name>
        <name evidence="13" type="ORF">PROQFM164_S06g000086</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Transport of phosphate groups from the cytosol to the mitochondrial matrix.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792020">
        <property type="protein sequence ID" value="CDM37126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QMC7"/>
    <dbReference type="STRING" id="1365484.W6QMC7"/>
    <dbReference type="OMA" id="PERAYAW"/>
    <dbReference type="OrthoDB" id="427452at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035434">
        <property type="term" value="P:copper ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990547">
        <property type="term" value="P:mitochondrial phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000076">
        <property type="entry name" value="Mitochondrial phosphate carrier protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000131">
        <property type="entry name" value="Mitochondrial phosphate carrier protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044677">
        <property type="entry name" value="SLC25A3/Pic2/Mir1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45671:SF13">
        <property type="entry name" value="PHOSPHATE TRANSPORTER PIC2, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G12080)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45671">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25 (MITOCHONDRIAL CARRIER PHOSPHATE CARRIER), MEMBER 3, LIKE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="19"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="113"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="214"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00054508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDM37126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="307" mass="34051" checksum="A2BF96C2E92631C5" modified="2014-04-16" version="1">MTTQERRLPFGKIEPNSLKYFASCALGGVIACGPTHTAVTPLDLVKCRRQVDPKIYTSNIQAWKTIFSKEGLHGVFFGWSPTFLGYSMQGAGKYGLYEYFKYIYGNQMFPHANPTLVFLGASATAEFFADMALCPMEAIKVRMQTTLPPFASSMREGWGKIVTKEGYAGLYKGLYPLWARQIPYTMTKFATFEETVKLIYRTMGKPKEEYSQLQQTGVSFLGGYIAGIFCALVSHPADVMVSKLNADRKAGEGAMTAVSRIYGKIGFPGLWNGLPVRIVMLGTLTGFQWLIYDSFKVFLGLPTTGGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W6QN90</accession>
    <name>W6QN90_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S07g000203</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792021">
        <property type="protein sequence ID" value="CDM37855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QN90"/>
    <dbReference type="OrthoDB" id="4329376at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM37855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="144" mass="16478" checksum="4152BDB1D9E615DE" modified="2014-04-16" version="1">MEPLTTMRIQASFDCNICTQGSIKCNPLRHIQSEIQSEPGLRNAVRMAIPLGKNQFDLAVEFATVIQVGEYFTDLSRWRLMSCDPLFTAELGRSYQETAFSALTQMRYQYNMAASLIQVSGDPRLANWFKSEIVRIEGLLEQYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W6QNF5</accession>
    <name>W6QNF5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein kinase-like domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S06g000448</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792020">
        <property type="protein sequence ID" value="CDM37486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QNF5"/>
    <dbReference type="STRING" id="1365484.W6QNF5"/>
    <dbReference type="OMA" id="CQPFGKR"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044773">
        <property type="term" value="P:mitotic DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167">
        <property type="entry name" value="OVARIAN-SPECIFIC SERINE/THREONINE-PROTEIN KINASE LOK-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167:SF24">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE CHK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="43"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM37486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="270" mass="31180" checksum="75857B986B5BF37D" modified="2014-04-16" version="1">MSFVDQASPKNEIKFEQKPLIKSLQDLNIVESWKDGKLKSTTFYHVTENEEVFFGYTSKNKRETSIPEFNSALQRVQDQDIYPTIPADTHLTLAPEGLSASSVYVKRPGLQWYEEMIGTDYLPKAVLDETMVMEQISQSPHENIIRYYGCRVRRGYITSIVLERLDQTLSQYVTTSDFQELDKVKFFESLKSAVEHLHTLGLAHNDINPDNIMVKNGSPVLIDFDSCQPFGKRLQSLGTEGWYEEVFYTSEKKHDIYSLEKLQEWLQAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W6QNQ0</accession>
    <name>W6QNQ0_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">L-Aspartase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S04g000615</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
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        </source>
    </evidence>
    <sequence length="1412" mass="153518" checksum="FF4D877039CEF1ED" modified="2014-04-16" version="1">METQDDSIDLAKLQRDALGLEHDPYLSRSTQKGNEPNHTLCYTSHKVNGASNGDGVCNGQQLPPKTPSNPASLVHQYRPSLYRPRQHEPRTMMFNKSGNEPGIVPGSQFGNMSSAPGDTQVISQSVYDKIIRQNGESMQQDYTQTGADGATLRTLYEGDSGHIDLLSELDTVHHGTNLSQDDDDNDDGSNSDPNESSPMAYAPDLFPESQRFLAETPGTVVKKNEAGGTAETPSISRNPLASGIESSGGLLGLSQVFGATQAPSSPIVHGLQTELVSDRPSPNIPIQSARVVNGISSPLMGLPVQFTRDSSEPNMNYISMKESQKRRDKTLGERLTRSADNIQSDQSDKEFYKESSFIERARRQREIDEEAAAQFAGLSAPARSTSNLSARLRTPSEQPGEQQDQEMIEAVASEEETEQEEDMQVPRSQEPPQSSAEEDKENYEGPPMDTAAAAAAAASAHDRLSQVLGFEPILSPSRMRVDEQPDDGIAHGGSGSQPNGATSSSQAMVKDSQPSPQSSAKLIEPEITRKITHRSPSRSHMNSPTRDLPSSPCSRPQSRHSNSHTQRNGSVSNEYAIQHVQTTALNENIPTYSSNPSEQQHLNSSHSRVEAGTSGNSSSMPSRVAETPMNQRLKHLGDMARLTSIPETSPSHSQCNSVAGSNGDGLNNEDDDLPPMLFNEVPSIRNNHIRPAGARALSSPLKKLLSSPGGGQRRALTEIAGDLSPQVGAGGFDMGIGIFTAEDREFKALIDGSPTRPKKKRRGNDGSSYIASDPIIPFTPRTQPPKSVAPIRATQERPAPIPEVPDSDDVPLVQLPEKAVRRQSKPPRRAPENVWEIERSPEQPFRQRSRIGKTSTSMSTQGKYVSEKRSVPPPKVVVHSRPPPPSSELTEVSSTIASDDIIESEAYSVDDSPTTPRPSHTLSENTVVAPSQVLSVWMGQKRAYYPATCFGTPLGVSQVKYSVRFEDSLPIEVPKGAVKRFELRVGDAVKIEMDNIPKVTHVVRGFDDKLTKEELAKAADDGLYPITDIYGHTTIIVGPKQRKSLPNGGMGNGENVIKVPISRVYLDTILWNQLKDRAFTYRPAPVQQESMVHTPSERSSAPASPSCRLSRSLHQGSGIFAGMVFAVSYREDEASKNRVTRLIVDNGGTVLHDGFTELFEPSTIVSVDTPIKGGAKDAGINSKGLRLTALAEEVGFACLIADTYSRREKYMQALALNLPCLSGRWVEDCIAQGRVLDWDIYLLPAGDSMYLNGATKSRVMAPNPPSTARLTETISARKKLLAGQSVLVVMGRGKVEEKRKAYIFLTYALGASRVERVPDLGTASALIDSQSDAGLSTDWDWIYVDDADQAAAKSMLTPKPQTPRIHLFHGKKRKRSIASSTPTPPNEPKCTARVVGNEFVCQSLILGRLFEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W6QPU2</accession>
    <name>W6QPU2_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Bifunctional polymyxin resistance protein, ArnA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S12g000049</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792026">
        <property type="protein sequence ID" value="CDM38440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QPU2"/>
    <dbReference type="STRING" id="1365484.W6QPU2"/>
    <dbReference type="OMA" id="RRNTWHY"/>
    <dbReference type="OrthoDB" id="1731983at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd08948">
        <property type="entry name" value="5beta-POR_like_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055222">
        <property type="entry name" value="PRISE-like_Rossmann-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32487">
        <property type="entry name" value="3-OXO-DELTA(4,5)-STEROID 5-BETA-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32487:SF0">
        <property type="entry name" value="3-OXO-DELTA(4,5)-STEROID 5-BETA-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22917">
        <property type="entry name" value="PRISE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PRISE-like Rossmann-fold" evidence="1">
        <location>
            <begin position="25"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM38440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="397" mass="45900" checksum="A15EFF771D5DBB7F" modified="2014-04-16" version="1">MHSVRKHGRRKPQYYAMPLTKGKTAFVTGVNGISGHAIVEHLIREPETEWSQIIISSRRPLATHWIDPRVVFVAIDLLDPTENIKQSLSTLVENVTHAFFTSYVHTANFDTLREKNIPLFANFIDALDELCPRLERVCLQTGGKNYGVHLGPVKYPLVEDGPRYTDKNNFYFHQEDYMFDVQKKRKSWDYNIIRPNGIFGFTPHGSGMSEVLSLAIYFLVCRELQEPARFCGNEFLWTNVDNKSSAWGLAHMSVWAVTQVQCKNEAFNYVNGDVFVWKNLWADLAGYFEADAPEPKFMNAAGVSDKLTNEFDILEWSKDKRPVWERVVAKYGGKVEAWDWTSWDSVMWAMGRSWPTIASMSKARRFGWTRYDDSHDNYFQTIRSLENADILPKITKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W6QQ08</accession>
    <name>W6QQ08_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S08g000127</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792022">
        <property type="protein sequence ID" value="CDM38076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QQ08"/>
    <dbReference type="STRING" id="1365484.W6QQ08"/>
    <dbReference type="OrthoDB" id="4284689at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM38076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="178" mass="19658" checksum="F6FFDDEDD8471F01" modified="2014-04-16" version="1">MAQRMIEDLISVMEGGLEFTQGIPTDRKQVLEVSINLFSGVKAPELVSTNHKKVPKGVQKRFVKYMNEFCQANLGQVKLRPSGNIGDIDELTNIQRELICTTPILVNNNLGVNSTWLEGGTTISGLPLLSAGSMTLLETKSPDVIIELNYHNQAFARSETDKVFTSGNINLNIFLVHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W6QQN3</accession>
    <name>W6QQN3_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major facilitator superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PROQFM164_S05g000222</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. TCR/Tet family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QQN3"/>
    <dbReference type="STRING" id="1365484.W6QQN3"/>
    <dbReference type="OMA" id="DVYVMAI"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF12">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="228"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="268"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="302"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="343"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="382"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="407"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="439"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="482"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="548"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="74"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM36389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="571" mass="61704" checksum="4C337F17C1BC7643" modified="2014-04-16" version="1">MDIDTGTWITSSTFKRLTKWHSLFTMSVDNPTPSDSVLESQTPDRVDESIIKAADAEKDAAPRREIVGLRWLLVCIAVFSANLLYGLDNTIVADIQGPIAGDFDEYTRLGWLGVGFTLGSVVFILPLGKAYAIFDTKWLFLGCLTMFAAGSALCGAAPSMNAIIVGRVWAGAGGAGMYLGNLNLITILTTPTEQPVYVGLVGLIYGTGCILGPIIGGAFSDSSATWRWSFYLNLVIFGVMSPIYVFLLPSLPRPAGEGRSFIKKLVELDWVGTLLSAGMHISIILFIVFGGVEWSWTDGRNIALYVVSAVCTIAFVLSQYYCVGTDKQNRLFPCEFLRNPTMLLLYVIMACGGASLFVAVYYIPLYFQFIQGDSGIMSAVRLLPFVCFYVATILLCGWVMPKTGFFILWYLVSGIFILIGAVLMYTVKLGTSPSSIYGYSILMGLGMTTTQAAYAVGPTIVSPDRVAECLQFMNIGQGQSQLLGLAIASAIFQSKTLTGLTTLLGNKGYSHADIQGAVAGAQSTLMERLPQALKTEALEVIVNSISDVYVMAISAGALYVVASCLLPRRRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W6QR07</accession>
    <name>W6QR07_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type DNA-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PROQFM164_S12g000005</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792026">
        <property type="protein sequence ID" value="CDM38396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QR07"/>
    <dbReference type="OMA" id="HASVESC"/>
    <dbReference type="OrthoDB" id="3266505at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053187">
        <property type="entry name" value="Notoamide_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47256:SF10">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47256">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="37"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDM38396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="135" mass="15156" checksum="10D3720E4E172226" modified="2014-04-16" version="1">MTGQNALRPLRPMVQASLSQLQTSPSSCGKRQNVSLACTNCRQKRTKCSGALPCANCKAKLCQCIYDPSSDRRRKSYSIESSALRQALLYTVVKLRSRARDEVKTFISKIRSLQTDRDGENFLLRESSHAIDNSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W6QR88</accession>
    <name>W6QR88_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">4-hydroxyphenylpyruvate dioxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PROQFM164_S05g000412</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM164</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="11">Binds 1 Fe cation per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 3/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the 4HPPD family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QR88"/>
    <dbReference type="STRING" id="1365484.W6QR88"/>
    <dbReference type="OMA" id="DMCSEYS"/>
    <dbReference type="OrthoDB" id="414569at2759"/>
    <dbReference type="UniPathway" id="UPA00139">
        <property type="reaction ID" value="UER00362"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003868">
        <property type="term" value="F:4-hydroxyphenylpyruvate dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006572">
        <property type="term" value="P:L-tyrosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07250">
        <property type="entry name" value="HPPD_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08342">
        <property type="entry name" value="HPPD_N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.180.10:FF:000001">
        <property type="entry name" value="4-hydroxyphenylpyruvate dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005956">
        <property type="entry name" value="4OHPhenylPyrv_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041735">
        <property type="entry name" value="4OHPhenylPyrv_dOase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041736">
        <property type="entry name" value="4OHPhenylPyrv_dOase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC_core"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01263">
        <property type="entry name" value="4HPPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11959">
        <property type="entry name" value="4-HYDROXYPHENYLPYRUVATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11959:SF1">
        <property type="entry name" value="4-HYDROXYPHENYLPYRUVATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009283">
        <property type="entry name" value="HPP_dOase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="8 11" id="KW-0408">Iron</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-0585">Phenylalanine catabolism</keyword>
    <keyword evidence="13" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0828">Tyrosine catabolism</keyword>
    <feature type="domain" description="VOC" evidence="12">
        <location>
            <begin position="20"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="VOC" evidence="12">
        <location>
            <begin position="206"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="292"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="375"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR009283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR009283-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDM36579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="407" mass="45461" checksum="AF44C1A2926DFA79" modified="2014-04-16" version="1">MTVPENEDIFPAKMGPEYVGFDHIHWYVGNPKQAATYWITRMGFRPVAYRGPENGSPYLVSYVVANSDATFVLTGPVCGPPNQDPEDGILRQASIYERAMLAEIHKHLTIHGDGVKDVAFRIAGDIQAVWNRAIGNGARAITEPRTFSVEGHGSIVSATVGTYGDTVHTLVNRERYSAGAPFLPGYRLLDSEDPITQLLPPINLLEIDHCVGNQSWGGVDSIVQYYEECLDFHRYWTVDDKDMCSEYSAMRSIVIASPNETIKMPMNEPATGKKKSQIEEFVDYYHGAGVQHIAFRTHDIVAAVTSLQARGVQFLSVPATYYADLRKRLTQVSWTLGADVDVLEQLNILVDFDERGYLLQIFSKHVGDRPTVFIEVIQRNSFDGFGAGNFKSLFEAFEREQALRGNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W6QRD8</accession>
    <name>W6QRD8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ankyrin repeat-containing domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S15g000010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792029">
        <property type="protein sequence ID" value="CDM38546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QRD8"/>
    <dbReference type="OrthoDB" id="2157530at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="17"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="14"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM38546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="53" mass="5956" checksum="BAB0B16AB539D193" modified="2014-04-16" version="1">MRYTVQRIDLKHDHGQIALHFAAFVGRIGFVHLLLSSGSSPDLQDDLGHSPWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W6QVH2</accession>
    <name>W6QVH2_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">GPI mannosyltransferase 1</fullName>
            <ecNumber evidence="13">2.4.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">GPI mannosyltransferase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">gpi14</name>
        <name evidence="15" type="ORF">PROQFM164_S09g000040</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 13">Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the first alpha-1,4-mannose to GlcN-acyl-PI during GPI precursor assembly. Required for cell wall integrity.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Endoplasmic reticulum membrane</location>
            <topology evidence="1 13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the PIGM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="13"/>
    <dbReference type="EMBL" id="HG792023">
        <property type="protein sequence ID" value="CDM38124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QVH2"/>
    <dbReference type="STRING" id="1365484.W6QVH2"/>
    <dbReference type="OMA" id="MLWFIGQ"/>
    <dbReference type="OrthoDB" id="1741594at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990529">
        <property type="term" value="C:glycosylphosphatidylinositol-mannosyltransferase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051751">
        <property type="term" value="F:alpha-1,4-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004376">
        <property type="term" value="F:GPI mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007704">
        <property type="entry name" value="PIG-M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12886:SF0">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12886">
        <property type="entry name" value="PIG-M MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05007">
        <property type="entry name" value="Mannosyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 13 15" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5 13" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <keyword evidence="7 13 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004879897" description="GPI mannosyltransferase 1" evidence="14">
        <location>
            <begin position="33"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="168"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="222"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="284"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="351"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="382"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU365064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CDM38124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="420" mass="46632" checksum="BCB6C03E9AB81F7E" modified="2014-04-16" version="1">MAIFDSPARVFLAATALRLIFLVYGGWQDAHSTVKYTDIDYMVFTDAARYVAKGESPYTRDTYRYTPLLAWMLLPTAWEGATPWSTLTFAFGKALFALSDVLAGWLVVQLLVRCYQFPVERALRYVSAVWLWNPMVANISTRGSSEGLLGVLVAALLWATLTKKPVLAGLILGLAVHFKIYPFIYGVSILWWWDAERDGSVTTGSGLLSKALGFITPSRVKFTVAALASFVALNLVMYLQHGQPFLHHTFFHHLTRIDHRHNFSPYSTLLYLSAAGGAETRFEALAFLPQLILVVVALPLVLAKKSLTTTMLAQTFTFVTFNKVCTSQYFLWYLILLPFYLPSSSLIRKPALGISAAILWIAGQALWLHQGYNLEFLGLSSFVPGLFLAGLFFFAVNVWILGIIVRDGGDGAGEITTALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>W6QW17</accession>
    <name>W6QW17_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 25">tRNA-dihydrouridine(47) synthase [NAD(P)(+)]</fullName>
            <ecNumber evidence="4 25">1.3.1.89</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="25">tRNA-dihydrouridine synthase 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="28" type="primary">dus3</name>
        <name evidence="28" type="ORF">PROQFM164_S11g000002</name>
    </gene>
    <organism evidence="28 29">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="28" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="28">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="19">Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. Specifically modifies U47 in cytoplasmic tRNAs. Catalyzes the synthesis of dihydrouridine in some mRNAs, thereby affecting their translation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>5,6-dihydrouridine(47) in tRNA + NAD(+) = uridine(47) in tRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53364"/>
            <dbReference type="Rhea" id="RHEA-COMP:13539"/>
            <dbReference type="Rhea" id="RHEA-COMP:13540"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.89"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="20">
            <dbReference type="Rhea" id="RHEA:53366"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>5,6-dihydrouridine(47) in tRNA + NADP(+) = uridine(47) in tRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53360"/>
            <dbReference type="Rhea" id="RHEA-COMP:13539"/>
            <dbReference type="Rhea" id="RHEA-COMP:13540"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.89"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="23">
            <dbReference type="Rhea" id="RHEA:53362"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>a 5,6-dihydrouridine in mRNA + NAD(+) = a uridine in mRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69851"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="21">
            <dbReference type="Rhea" id="RHEA:69853"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>a 5,6-dihydrouridine in mRNA + NADP(+) = a uridine in mRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69855"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="22">
            <dbReference type="Rhea" id="RHEA:69857"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 25">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="25">Belongs to the dus family. Dus3 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.89" evidence="4 25"/>
    <dbReference type="EMBL" id="HG792025">
        <property type="protein sequence ID" value="CDM38299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QW17"/>
    <dbReference type="STRING" id="1365484.W6QW17"/>
    <dbReference type="OMA" id="WSYIAEC"/>
    <dbReference type="OrthoDB" id="259935at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106414">
        <property type="term" value="F:mRNA dihydrouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102265">
        <property type="term" value="F:tRNA-dihydrouridine47 synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02801">
        <property type="entry name" value="DUS_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000145">
        <property type="entry name" value="tRNA-dihydrouridine(47) synthase [NAD(P)(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018517">
        <property type="entry name" value="tRNA_hU_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45846">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(47) SYNTHASE [NAD(P)(+)]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45846:SF1">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(47) SYNTHASE [NAD(P)(+)]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25585">
        <property type="entry name" value="zf-CCCH_DUS3L"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01136">
        <property type="entry name" value="UPF0034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 25" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8 25" id="KW-0288">FMN</keyword>
    <keyword evidence="11 24 25" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="17 25" id="KW-0520">NAD</keyword>
    <keyword evidence="15 25" id="KW-0521">NADP</keyword>
    <keyword evidence="18" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16 25" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0677">Repeat</keyword>
    <keyword evidence="10 25" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="14 24 25" id="KW-0862">Zinc</keyword>
    <keyword evidence="13 24 25" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="27">
        <location>
            <begin position="122"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="24">
        <location>
            <begin position="122"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="26">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="26">
        <location>
            <begin position="39"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="26">
        <location>
            <begin position="92"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00045934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00049447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00049513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="RuleBase" id="RU291113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="EMBL" id="CDM38299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="728" mass="81603" checksum="92C25F6E56D00C07" modified="2014-04-16" version="1">MEPETIQAQAPVANVATPDSEIPKRDAANDPGAADVEEPPAKKARLDEPSKPAQVDMRDRGIAPIKAEYRIHITPKPRPADETNPDDAAEGAAHDDRDGGKKDKGKKKKKGQNTNRTYGTSKDAKGLCSTRMFANEFAAGECQYGEKCRFEHDLRVYLKEHKREDLTTLNNMCPVYEALGKCSSGWKCRMVGSHSTERETEDGKKELILLEDAERMEKARPRVAHATPEGIVNIISNQDKMALTRKREDTPRADAYTTWSVQVSAELEKAIHQRSTIREKGELVEPDEQAKIDLQENRAQFLEPPFMPSEKRRIYFGPETPVLAPLTTQGNMPFRRLCTDLGAQFTYSEMAMSMPLIQGSKSEWTLLKAHESEMTPPTVIPGDNVVQGYDNSKDFKFGAQIAANKPWQALKATEVLSKFTPNLRVIDLNCGCPIELVFRDGAGSALLDHHSKLEKMIRGMNTVSLEIPITVKIRMGTKDNQPTAQKLVERMVLGGYESSVLDLGPPGAAAITLHGRSRQQRYTRQADWGYISDCAALIKRLNKKQDALTDTIREPDARHMPNGGKTYFVGNGDCYSHTDYDDHVNNAGVDSVMVARGALIKPWIFEEIQTGQYLDKSATERLAYIEKFAKYGLQAWGSDEHGVGTTRRFMLEWLSFAYRYVPIGLLEHLPPNIQDRPPAWRGRNELETLMGSGNYKDWIKITEMFLGPAPDTFKFEPKHKSNSYEAEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W6QXY5</accession>
    <name>W6QXY5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S03</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S03g001121</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QXY5"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM34397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="54" mass="5995" checksum="6BCE48E62A2114FA" modified="2014-04-16" version="1">MKYPGVQDSCCTSDRGPDSRQVGKTKASGTIKRTLTSWTSRVELPLELDYLCKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>W6QZF0</accession>
    <name>W6QZF0_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Fatty acid synthase subunit alpha</fullName>
            <ecNumber evidence="3">1.1.1.100</ecNumber>
            <ecNumber evidence="4">2.3.1.41</ecNumber>
            <ecNumber evidence="2">2.3.1.86</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="30" type="primary">FAS2</name>
        <name evidence="30" type="ORF">PROQFM164_S03g001659</name>
    </gene>
    <organism evidence="30 31">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="30" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="30">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>a (3R)-hydroxyacyl-[ACP] + NADP(+) = a 3-oxoacyl-[ACP] + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17397"/>
            <dbReference type="Rhea" id="RHEA-COMP:9916"/>
            <dbReference type="Rhea" id="RHEA-COMP:9945"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78776"/>
            <dbReference type="ChEBI" id="CHEBI:78827"/>
            <dbReference type="EC" id="1.1.1.100"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>a fatty acyl-[ACP] + malonyl-[ACP] + H(+) = a 3-oxoacyl-[ACP] + holo-[ACP] + CO2</text>
            <dbReference type="Rhea" id="RHEA:22836"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9916"/>
            <dbReference type="Rhea" id="RHEA-COMP:14125"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78776"/>
            <dbReference type="ChEBI" id="CHEBI:138651"/>
            <dbReference type="EC" id="2.3.1.41"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>acetyl-CoA + n malonyl-CoA + 2n NADPH + 4n H(+) = a long-chain-acyl-CoA + n CoA + n CO2 + 2n NADP(+).</text>
            <dbReference type="EC" id="2.3.1.86"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 22">Belongs to the thiolase-like superfamily. Fungal fatty acid synthetase subunit alpha family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.100" evidence="3"/>
    <dbReference type="EC" id="2.3.1.41" evidence="4"/>
    <dbReference type="EC" id="2.3.1.86" evidence="2"/>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1365484.W6QZF0"/>
    <dbReference type="OMA" id="FPTLPDW"/>
    <dbReference type="OrthoDB" id="4251012at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005835">
        <property type="term" value="C:fatty acid synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004316">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004321">
        <property type="term" value="F:fatty-acyl-CoA synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008897">
        <property type="term" value="F:holo-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042759">
        <property type="term" value="P:long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00828">
        <property type="entry name" value="elong_cond_enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08950">
        <property type="entry name" value="KR_fFAS_SDR_c_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.470.20:FF:000005">
        <property type="entry name" value="Fatty acid synthase alpha subunit FasA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2490:FF:000001">
        <property type="entry name" value="Fatty acid synthase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.25.70:FF:000001">
        <property type="entry name" value="Fatty acid synthase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.20">
        <property type="entry name" value="4'-phosphopantetheinyl transferase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00101">
        <property type="entry name" value="AcpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008278">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037143">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002582">
        <property type="entry name" value="ACPS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040899">
        <property type="entry name" value="Fas_alpha_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047224">
        <property type="entry name" value="FAS_alpha_su_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026025">
        <property type="entry name" value="FAS_alpha_yeast"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041550">
        <property type="entry name" value="FASI_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050830">
        <property type="entry name" value="Fungal_FAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004568">
        <property type="entry name" value="Ppantetheine-prot_Trfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00556">
        <property type="entry name" value="pantethn_trn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10982:SF21">
        <property type="entry name" value="FATTY ACID SYNTHASE SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10982">
        <property type="entry name" value="MALONYL COA-ACYL CARRIER PROTEIN TRANSACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01648">
        <property type="entry name" value="ACPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18325">
        <property type="entry name" value="Fas_alpha_ACP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18314">
        <property type="entry name" value="FAS_I_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000454">
        <property type="entry name" value="FAS_yeast_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56214">
        <property type="entry name" value="4'-phosphopantetheinyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="17" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="7" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="16" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 25" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10 25" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="15" id="KW-0520">NAD</keyword>
    <keyword evidence="13" id="KW-0521">NADP</keyword>
    <keyword evidence="14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6 22 26" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="31" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 22" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carrier" evidence="28">
        <location>
            <begin position="137"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="29">
        <location>
            <begin position="1090"/>
            <end position="1628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="27">
        <location>
            <begin position="96"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="27">
        <location>
            <begin position="102"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="active site" description="For beta-ketoacyl synthase activity" evidence="23">
        <location>
            <position position="1273"/>
        </location>
    </feature>
    <feature type="binding site" evidence="24">
        <location>
            <begin position="1738"/>
            <end position="1740"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="25">
        <location>
            <position position="1738"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="25">
        <location>
            <position position="1739"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="25">
        <location>
            <position position="1740"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="24">
        <location>
            <position position="1764"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="24">
        <location>
            <position position="1774"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="24">
        <location>
            <begin position="1783"/>
            <end position="1799"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="24">
        <location>
            <begin position="1807"/>
            <end position="1810"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="24">
        <location>
            <begin position="1837"/>
            <end position="1839"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="25">
        <location>
            <position position="1838"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="25">
        <location>
            <position position="1839"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="26">
        <location>
            <position position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00049541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PIRNR" id="PIRNR000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PIRSR" id="PIRSR000454-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="PIRSR" id="PIRSR000454-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="PIRSR" id="PIRSR000454-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="PIRSR" id="PIRSR000454-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="EMBL" id="CDM34932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="1852" mass="203804" checksum="6B01FE2867DC5988" modified="2014-04-16" version="1">MRPEVEQELAHTLLVELLAYQFASPVRWIETQDVILAEQRTERIVEIGPADTLGGMARRTLASKYEAYDAATSVQRQILCYNKDANEIYYDVEPVEEEPEAAAEPASSAPAAAAPAAGAPPPPPSAGPAASVEDAPVTAVDIVRTLVAQKLKKSLADVPLSKAIKDLVGGKSTLQNEILGDLGKEFGSTPEKPEDVPLDELGASMQATFNGQLGKQSSSLIARMVSSKMPGGFNITAVRKYLETRWGLGSGRQDGVLLLALTMEPPARLASETDAKAYIDGVTNKYATNAGVNLSAPVAGGDGGGGGGGMVMDPAALDALTKDQRALFKQQLEIIARYLKMDLRGGEKAYVTSQENQQVLQAQLDLWQVEHGDFYATGIEPSFNPLKARVYDSSWNWARQDALSMYYDIIFGRLQVVDREIVSQCIRIMNRSNPLLLDFMQYHIDNCPTERGETYQLAKELGQQLIENCREVLEVAPVYKDVAVPTGPQTTIDARGNIGYKEAPRTSARKLEHYVKHMAEGGPISEYSNRTKVQNDLKSVYKLIRKQHRLSKSSQIQFDALYKDVVHALGMNESQIIPQENGHSKKGGRSAAKRVTATRPGKMETIPFLHLKKKTDHGWDYNKRLTGVYLNVLESAAKNGLSFQGKNVLMTGAGAGSIGAEVLQGLISGGAQVVVTTSRFSREVTEYYQAMYTRYGARGSQLVVVPFNQGSKQDVEALVDYIYDTKKGLGWDLDFIVPFAAIPENGREIDSIDSKSELAHRIMLTNLLRLLGSVKTHKQAHGYETRPAQVVLPLSPNHGTFGNDGLYSESKLALETLFNRWYSENWGHYLTICGAVIGWTRGTGLMSGNNMVAEGVEKLGVRTFSQQEMAFNLLGLMSPAIVNICQLDPVFADLNGGLQFIPDLQSLMTKLRTDIMETSDVRQAVIKETAIEHKVVNGEDGGVLYKKVVAEPRANIKFEFPKLPDWEKEVKPLNESLKGMVNLDKVVVVTGFAEVGPYGNSRTRWEMESKGKFSLEGCVEMAWIMGLIKHHNGPLKGQAYSGWVDSKTGEPVDDKDIKPKYEKHILEHTGIRLIEPELFKGYDPKKKQLLQEIVIQEDLEPFEASKETAEEFKREHGDKVEIFEIPESGEYTVRLRKGATMLIPKALQFDRLVAGQVPTGWDASRYGIPEDIIEQVDPVTLFVLVCTAESMLSAGITDPYEFYKYVHLSEVGNCIGSGIGGTHALRGMYKDRFMDKPLQKDILQESFINTMSAWVNMLLLSSTGPIKTPVGACATAVESVDIGYETIVEGKARVCFVGGFDDFQEEGSYEFANMKATSNAEEEFAHGRTPQEMSRPATTTRAGFMESQGCGMQLIMTAQLALDMGVPIHGIIALTTTATDKIGRSVPAPGQGVLTTARENPGKFPSPLLDIKYRRRQLDLRKKQINEWQEAELLYLQEEADAMKAQSDETFNEAEYMQERAQHIEREAIRQKKDAQYSLGNNFWKQDPRIAPLRGAMATWGLTVDDIDIASFHGTSTVANDKNESDVLCQQMKHLGRTKGNAVMGIFQKYLTGHPKGAAGAWMFNGCLQVLESGLVPGNRNADNVDKVMEKFDYIVYPSRSIQTDGVKAFSVTSFGFGQKGAQVIGIHPKYLFATLDQAQYETYKTKVEARQKKAYRYFHNGLINNSIFVAKTKAPYEDDLQSKVFLNPDYRVSVDKKTSELKYSATGPEAKKSESTRQTLESLAKANAAENSKIGVDVEHIDSVNIENETFVERNFTQSEQDYCRKAPSPQSSFAGRWSAKEAVFKSLGVSSKGAGAALKDIEIGVDANGAPVVNLHGAAAAAAKQAGVKNVSVSISHSDSQAVAVAVSQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W6R014</accession>
    <name>W6R014_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Smr protein/MutS2 C-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S04g000038</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6R014"/>
    <dbReference type="STRING" id="1365484.W6R014"/>
    <dbReference type="OMA" id="ELENEYC"/>
    <dbReference type="OrthoDB" id="443981at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14279">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003892">
        <property type="entry name" value="CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052772">
        <property type="entry name" value="Endo/PolyKinase_Domain-Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002625">
        <property type="entry name" value="Smr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036063">
        <property type="entry name" value="Smr_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058864">
        <property type="entry name" value="UBA_10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46535">
        <property type="entry name" value="NEDD4-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46535:SF1">
        <property type="entry name" value="NEDD4-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26286">
        <property type="entry name" value="UBA_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00463">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160443">
        <property type="entry name" value="SMR domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51140">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50828">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CUE" evidence="3">
        <location>
            <begin position="134"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="Smr" evidence="2">
        <location>
            <begin position="464"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM35157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="553" mass="60376" checksum="A6B1FF50E9E0EC78" modified="2014-04-16" version="1">MITAMGDCGDELFKELESTYCPPIDPALFVAIVSDFDLAIPTQVEQLRDTLNLLNASAVEQADLPFDPTGTTNLRNSDVSGSLGGESSDDAPSDFTSWPSLESLDQDNGDSNSASRHAEKLKGSKLAYTFLGMSTADKAQNLISMFPSITRLEAERILEDCHDNLSRSMDVLLNLAFIEETQIAREVPQETPKEAAQGGQFSTPKSIDGFQANENQNGSKKSRKKKKQQQQQRRIELASQAMNNTSANKWEAGKKDIEFLSSRASALQREKIASTYHENSMSLGATIRVLAQIHGPKDIQEIEDDPVLITQVGELSHKYPGINATTLTGLVRISSNQISAADELAEKLARRPDLTCISNIISFVSSPIALDEEENVAPAQQADSASDFMEFDEAAAAANSHFAARSVALAQASQAARRARSNPLYGGASAYYRDVGNEQRQLAMRHLATASDRLVARQSSQYDLDLHGVTVVNAVRIARERVQAWWDGLGDQKYVRGGGQSSHGGFNIVCGVGHHSLDRKSHIGPAVWNMLLKEGWRVELNRGSMLVTGVNRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>W6R0C9</accession>
    <name>W6R0C9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Zn(2)-C6 fungal-type DNA-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PROQFM164_S04g000123</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6R0C9"/>
    <dbReference type="STRING" id="1365484.W6R0C9"/>
    <dbReference type="OMA" id="ITCLPPR"/>
    <dbReference type="OrthoDB" id="3921198at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF15">
        <property type="entry name" value="PRNA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="27"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="797"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="75"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM35242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="830" mass="92788" checksum="90E26C186C0F2959" modified="2014-04-16" version="1">MDDSTPTPTQQKRPRVAEENRKRAVRACDGCRRVKEKCEGGVPCRRCLRYRRQCNFTHIDPNEKTRSTSISLLDRAAAQSRNDIAEAERVRLMERLLSHYVPNITFDIQSLRQAAEDLKKKHRHSESDAISTREDPNELEDLAIDEEDFTIKAMPDNTTQYSGEFSYLNFTMKIRKKIDEWMKTAAPEATSEVEPFEERWRSTQLQSASPQVSASITCLPPRYVADFLVQIFFKYAQTNNFYIEEDWLVEKLGICYNDPESLSFDDAGAVCCILMVLAVGTQFAHMESPTPVNCLPPGSTANQDHHFSEDEVGLTFYQFASRLLPDIIATASVRSVQACLLIGTYLLPLDTSGLCYTYFGLALKLAIQNGMHRRYHGEGLSPRMIEVRNRVFWTAFTIEKRISILHGRPSSLSDPDVDGPLPVDFPGLMPVNQVSNHTNMVTLITLTLKLGEVSNEITSLRKYRKGQQQDCLERLLSLRKHLVDWWSTLPEEVTCRDLNPAGPLFRSNVHLKLDYCLTRVFIGRPFLFSNIKGISQNPSQGPSYKGSSSLSGLSKYRATLVTDCVEAALEIIDLCRLLRDETGLARASFTEFSSCRAALLVILAQGLTKRTERLGAALEQGISLIKIMSMGVGSARSAVSVIEALERAIRRLEAWSETQPDMSSGGTVESAYDRFKNWEMLWKAGPISPSTVAWQQQEAFAPSEQNIPQNIRSQASTMAGPATLLHGMSLTPSSAAMIGMGSAAPTPVAHDQSIPEGEDSLTDTFSLSHMPHFGFDHFVSNFPQELGEFTAIPCFEPDSQAQSNGLPRAEMKAPGNRSDPPHWLNFMRDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W6R5T2</accession>
    <name>W6R5T2_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S06g000133</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792020">
        <property type="protein sequence ID" value="CDM37172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6R5T2"/>
    <dbReference type="STRING" id="1365484.W6R5T2"/>
    <dbReference type="OMA" id="WREEDAC"/>
    <dbReference type="OrthoDB" id="5400577at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM37172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="89" mass="10545" checksum="114D0C96B02AD891" modified="2014-04-16" version="1">MGMKRQTCDLAKERRRARRKETGFQPDAYRENDAIRGKHKHTDESKALHLQYIELWIEFLIESGRVTDGYELEKGIPAPKITEIKEFIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W6PRW5</accession>
    <name>W6PRW5_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Small ribosomal subunit protein mS37</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g000310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the mitochondrial small ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the mitochondrion-specific ribosomal protein mS37 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PRW5"/>
    <dbReference type="STRING" id="1365484.W6PRW5"/>
    <dbReference type="OMA" id="INYHAAR"/>
    <dbReference type="OrthoDB" id="2210at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017264">
        <property type="entry name" value="Ribosomal_mS37_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28066">
        <property type="entry name" value="37S RIBOSOMAL PROTEIN MRP10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28066:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037706">
        <property type="entry name" value="MRP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR037706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM26501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="102" mass="11430" checksum="FE3EAF2D9F402016" modified="2014-04-16" version="1">MAPKGSLSTRLNPMRLNTINHLRVRRPNQNEQNPCVVVMSSMLNCWASAGYGAEGCSALEAQLRKCMDAPKSREQKKNTVNYHLMRMYPKVVGPRKKDGVLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W6PRX0</accession>
    <name>W6PRX0_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ornithine cyclodeaminase/mu-crystallin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S01g000315</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ornithine cyclodeaminase/mu-crystallin family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PRX0"/>
    <dbReference type="STRING" id="1365484.W6PRX0"/>
    <dbReference type="OMA" id="IYCCTPS"/>
    <dbReference type="OrthoDB" id="41492at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000556">
        <property type="entry name" value="Proline utilization protein PrnX-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1780.10">
        <property type="entry name" value="ornithine cyclodeaminase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003462">
        <property type="entry name" value="ODC_Mu_crystall"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023401">
        <property type="entry name" value="ODC_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13812">
        <property type="entry name" value="KETIMINE REDUCTASE MU-CRYSTALLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13812:SF19">
        <property type="entry name" value="KETIMINE REDUCTASE MU-CRYSTALLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02423">
        <property type="entry name" value="OCD_Mu_crystall"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="94"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="117"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="141"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM26506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="475" mass="52248" checksum="4710E69779A3B49B" modified="2014-04-16" version="1">MTLTVLSQTQLRELLHALSRDEILELQRNLGEALREYSSGSQEEGCSAAYQPQRTAITRQNGCTTLFMPASTGKTIGIKMISLQDGGAAGCANEQETVDAQEKDQISSRRRGSFRNSVASISSDLSDLSLGSQEDKEDTTNNDSSVAGSSTDSPTLLTGCVNQQNVTSNISRTLGAWPGAGTRDTSPRGSVTLLDDESLPFALINAHELTAFRTALASLMMFNRRKKVRTLLVFGAGTQAYWHIRLSLVLRGDDIRRVYIVNRSFDRAAKLLQDIYGPENSEWRGDVKFSAVSTDFGEYSRILKDHVRKADVIFCCTPSPVPLFPAEYLASSEGRQKGRLICAIGSYKAHMAEIHPDILRDEVTVQGPHRHWHKHIHRSGVILVDSLDAAMKEAGEIIQAGIKPKQVVELGELLMVRNAAREAATVDEEQSLREWAQRGNVIYKSVGLGLMDLVTGGDLVRLARERKLGTTVEDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W6PSA2</accession>
    <name>W6PSA2_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Carbon-nitrogen hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S01g000445</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PSA2"/>
    <dbReference type="STRING" id="1365484.W6PSA2"/>
    <dbReference type="OMA" id="FHLTNWI"/>
    <dbReference type="OrthoDB" id="412018at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07197">
        <property type="entry name" value="nitrilase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050345">
        <property type="entry name" value="Aliph_Amidase/BUP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43674:SF16">
        <property type="entry name" value="CARBON-NITROGEN FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G02350)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43674">
        <property type="entry name" value="NITRILASE C965.09-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM26636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="306" mass="33451" checksum="A5CE786801D81ACB" modified="2014-04-16" version="1">MPPFCKIAVIQLPEDNFARAVNFIREAAAQGCQLAVLPEFHLTNWIPTDPRFASLCEDWEVYLHRYQALAKECNICIVPGSIVRPVSASSAHVTEINKSDQRPTTPILENATFFISNTGEILGSYIKKNLWGPTERAYLRSSGDSPHQVIQTPLGPVGLLVCWDLAFPEAWRELTSNGAKIIIVPTLWTRSGASEAGRRQNPSAPSLFLDSILTARTFENTCAVVFANAGGPPGKNYCGLSQITIPYAGPLVRLGTSTEGMGVATLDMAVLEDAEENYGIRADMADPAWCYKHTQRTLAEVTKGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W6PT38</accession>
    <name>W6PT38_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Synaptobrevin homolog 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">syb1</name>
        <name evidence="11" type="ORF">PROQFM164_S01g001157</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the synaptobrevin family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PT38"/>
    <dbReference type="STRING" id="1365484.W6PT38"/>
    <dbReference type="OMA" id="VRKKMWW"/>
    <dbReference type="OrthoDB" id="190375at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061024">
        <property type="term" value="P:membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15874">
        <property type="entry name" value="R-SNARE_Snc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000063">
        <property type="entry name" value="Synaptobrevin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001388">
        <property type="entry name" value="Synaptobrevin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016444">
        <property type="entry name" value="Synaptobrevin/VAMP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45701">
        <property type="entry name" value="SYNAPTOBREVIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00957">
        <property type="entry name" value="Synaptobrevin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005409">
        <property type="entry name" value="Synaptobrevin_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00219">
        <property type="entry name" value="SYNAPTOBREVN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00417">
        <property type="entry name" value="SYNAPTOBREVIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50892">
        <property type="entry name" value="V_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="V-SNARE coiled-coil homology" evidence="10">
        <location>
            <begin position="30"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDM27348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="119" mass="12981" checksum="D513AA2AD8B5139D" modified="2014-04-16" version="1">MAASEQPYDPYIPSGSAGAPAATGQNGNQRTAALQAQIDDTVGVMRENINKVSQRGENLDSLQDKTDNLAVSAQGFRRGANRVRKDMWWKDMKMRVCLVICVIVLLIVIIVPSVVATKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W6PTD2</accession>
    <name>W6PTD2_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Nucleotide-binding, alpha-beta plait</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PROQFM164_S01g000949</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PTD2"/>
    <dbReference type="STRING" id="1365484.W6PTD2"/>
    <dbReference type="OMA" id="MPDSHAP"/>
    <dbReference type="OrthoDB" id="1049195at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050374">
        <property type="entry name" value="RRT5_SRSF_SR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003:SF3">
        <property type="entry name" value="FI21236P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003">
        <property type="entry name" value="RNA RECOGNITION MOTIF RRM DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="251"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="211"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDM27140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="401" mass="44206" checksum="D75DA40029B73100" modified="2014-04-16" version="1">MPLLGRDKYHPRSRRSDDEFVVFLQGIPPHCRWQELKDLVRQTALHIRQAVVYDDSHGFPTGLGQIIVKNEDEAWRTYHRLSTSGWEGQSLVVTLSRTSTPTKPIAGPTRSPAMMSTGYISGHSTPPSVHGNMAMPPSPVSPESSHPATPPYSYSEYGVMMVPIPMPPQGFMTMMPDSHAPPMQCFPPSPVMNGPMYEPYWNMMPGYQMSPPQHMHHQSDNQSQNHQNYHHRESRAKGTNLGSPFIYSDRRAIIIENLNPATTCTDLKILLQAAGAVQKCRIITMDSADFNGRLRGLVTMRTADEAQCAVTMFNNLSFFGSRIRVKLDRGSRLTRAVKVDGMLGVAGSDTTASVPGNRDMCQSWADEMTAEANAVGVSKPLVIDGSGLKKSVEISPISAPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W6PTK9</accession>
    <name>W6PTK9_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ATP synthase subunit gamma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">ATP3</name>
        <name evidence="12" type="ORF">PROQFM164_S01g000915</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM164</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="11">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) and CF(0) have multiple subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ATPase gamma chain family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PTK9"/>
    <dbReference type="STRING" id="1365484.W6PTK9"/>
    <dbReference type="OMA" id="MQITSAM"/>
    <dbReference type="OrthoDB" id="239812at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12151">
        <property type="entry name" value="F1-ATPase_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.80:FF:000001">
        <property type="entry name" value="ATP synthase gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1380.10:FF:000003">
        <property type="entry name" value="ATP synthase subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1380.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.80">
        <property type="entry name" value="ATP synthase, gamma subunit, helix hairpin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035968">
        <property type="entry name" value="ATP_synth_F1_ATPase_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000131">
        <property type="entry name" value="ATP_synth_F1_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023632">
        <property type="entry name" value="ATP_synth_F1_gsu_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01146">
        <property type="entry name" value="ATPsyn_F1gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11693">
        <property type="entry name" value="ATP SYNTHASE GAMMA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11693:SF22">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT GAMMA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00231">
        <property type="entry name" value="ATP-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039089">
        <property type="entry name" value="ATP_synthase_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00126">
        <property type="entry name" value="ATPASEGAMMA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52943">
        <property type="entry name" value="ATP synthase (F1-ATPase), gamma subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00153">
        <property type="entry name" value="ATPASE_GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="9 11" id="KW-0139">CF(1)</keyword>
    <keyword evidence="4 11" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="6 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDM27106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="297" mass="32252" checksum="0DB536CF9F8C756F" modified="2014-04-16" version="1">MFSRAVRPALRAGGAAVARPAPANAATFATLREIEGRLKSIKNIEKITNTMKIVASTRLTRAQKAMDESRVYGKTSNTLFEQAETKPLEDKKVLLVVASSDKGLCGGIHSGLSKATRRILADIPNADVVILGEKAKASLSRAAPENIVLSFSNVCKDIPTFADAQAIADQIALLPEDYASVRIIYNTFVNAQSYEPITLEAYSEEAITQSANISSYEVDDQVLSSLREYALANNLFWAMAEGHACEISARRNAMENASKNAGEMINKFQILYNRQRQATITGELVEIITGATASEDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>W6PTU3</accession>
    <name>W6PTU3_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Structural maintenance of chromosomes protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PROQFM164_S01g001074</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SMC family. SMC5 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PTU3"/>
    <dbReference type="STRING" id="1365484.W6PTU3"/>
    <dbReference type="OMA" id="RFWTSQP"/>
    <dbReference type="OrthoDB" id="10254973at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030915">
        <property type="term" value="C:Smc5-Smc6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45916">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45916:SF1">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecF/RecN/SMC N-terminal" evidence="6">
        <location>
            <begin position="95"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="407"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="735"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="253"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="407"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="735"/>
            <end position="754"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM27265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="1186" mass="133890" checksum="A29711C4C127C40D" modified="2014-04-16" version="1">MASPSIPRRRPHSEDEEDEDFTFTPQAQPSNNKRPRLDLAESDSGSDSGDESEGEGERERDGDSAGSEIPEAVSQVPRATAHDGLGPGGYKPGAIVRIKVTNFVTYTSAVFYPGPKLNMVIGPNGTGKSTLVCAICLGLGWGPQHLGRAKELGEFVKHGAREATIEIELCGPPKIGHNPVIQRLIKRDGNKSSFTLNGAPASKNDVLKLAQSFAIQVDNLCQFLPQDKVAEFAALTPIELLHSTQRAAAGPEMTQWHDALKRLRAEQKKLEMDNSGDKELLENMENRQEMQRADVERMRQRAVIKRKIEILERCRPIVEYKEHHNAVEALKVTKAVAEREYHRIQAENEPILRAVNAKEAYIARLNVVKDDRKDSVDEASRVATQRGQKIDEFENRMKDLKGRIEAEKKSGQRHKSEAASAQQAIHRLRRQQEEEAVEFDPEFYNETLREKRREKRELEAKAREIQDRRQPLQEQQQQVQRSIKQAELQLSSLDSASGQQELKLQKSSNDTLKAYRWLLENQSKFEKEVFGPPIVTCSITDPKFADAVESLFQKTDFTSFTVQTRNDFRTLQFAINQTLGLHDISIRTCSLSLDTMRPPMTNDQLAQLGFDGWARDFLVGPDPVIAMLCSEKSLHLTPIGLREISNEVFARLEEGSMSSWVSGKKSYQVTRRREYGPGATSTRVREIKPAQVWTEQPVDVSLKREHQENITLWNEQLQDIKEKLESERAAVKKISEEHEQTEREMTDIEKEKSAKQTAHTQYRAIPEKISQQEAKLQNITAMFDGVRERVREFRNQQDELAIQKAEVAVEYADAVELFRQAHEELMKVEVLFLEATSDLQTLRHRNIDSTKLLETKRRQAQEATVKLRESKVKARAVFQKAQQISRELHDQPDAQSLLEELNDHDIDKLEADIDSEKARLELTHGGSSQMIKEFEDRGKSIEKLRSKLADFMNKLTEIDNAITDIRKDWEPRLEALIEKISDAFSDSFRRIGCAGQVTLGKAEGEAGPNGEPGASEFGEWSIVIHVQFRQGAGLSVLDSHRQSGGERAVSTIFYLMALQSLSASPFRVVDEINQGMDPRNERMVHGRLVDIACASDETEETDEGGNPIGGGGGGQYFLITPKLLEQLSYKPGMRVLCIYSGEHMPEDYDKANFKKAIENMRKVAARAITSGPSEPMQSNGQVDVYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W6PTU5</accession>
    <name>W6PTU5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl transferase, family 54</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g001449</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PTU5"/>
    <dbReference type="OMA" id="SEILMGW"/>
    <dbReference type="OrthoDB" id="2016523at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22189">
        <property type="entry name" value="PGAP4-like_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029675">
        <property type="entry name" value="PGAP4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31410:SF1">
        <property type="entry name" value="POST-GPI ATTACHMENT TO PROTEINS FACTOR 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31410">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="259"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="292"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM27638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="443" mass="50305" checksum="A39C66BFFE8AF97F" modified="2014-04-16" version="1">MLLNRLVPTSGLSAISSVQVLRTFLFFPFFYVLLIMAARRQSSRDPSSIFFDPTKAYDPVYSAIRLEQAASFIDKANNATESQIQRGPRQPKFCLGIATIARKGASYFQATVGTFLEGLSEEERADIHLILFIAHTDPSQHPAYTEPWLYKLADEVLLYNASEIDIDHIRSLETNEAKIAGREKALFDYTYLLNACANIDTPYVIMLEDDLVALDGWYHRTKAALSSAEEQTREMGAANWLYLRLFYTEEYFGWNGEEWLTYLFFSILVVCFVACVPLVLRQFNHHARSFLPNMTIIIWSGIFTPLLIGLFFAMGRVTMLPRANGVHQMPRFGCCSQAFVFPQSRIPELVGLYTSKHIGYVDVLTEEYANARNEIRWAVTPSIVQHVGRKSSKGVDNDISSHVKIKSKAELTVVEKLWNFEFEMNDAEALRAEHDAVKQRGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W6PTW6</accession>
    <name>W6PTW6_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major facilitator superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PROQFM164_S01g001469</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PTW6"/>
    <dbReference type="STRING" id="1365484.W6PTW6"/>
    <dbReference type="OMA" id="PPQKWNM"/>
    <dbReference type="OrthoDB" id="440553at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000009">
        <property type="entry name" value="MFS multidrug transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF51">
        <property type="entry name" value="QUINIDINE RESISTANCE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="73"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="108"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="281"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="316"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="370"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="403"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="438"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="465"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="42"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM27658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="542" mass="59468" checksum="1C74C12D1214953F" modified="2014-04-16" version="1">MEKEIKQPSVSQPESGEDAGTRSGDLADVDYSVFTVSQRRYIVFMASWAGFFSPVSSQIYFPALNTLAKDLHVSNSLINLTLTSYMIFQGLSPMFIGDFADKAGRRPAYIVCFTIYIAANIGLALQNNYAALFVLRCLQSAGSSTTIALSSGGGADVATASQRGSYMGFVTAGSLMGPSVGPVIGGLLSQYLGWRAIFWFLTIFAAAFMVPFLIFFPETARGIVGDGSLPPQKWNMSLISYLDSRKAREGVISTAIVSKQKLKFPNPFQTLAIVFQKDTSLILFCNAILFAGFYDVSASIPAIFNELYGLDDLQIGLCYIPFGLGATIASVINGKFLDFNYRRLAKQLNFPLTKNRETDLRNFPIEKARLQLAFPLLTLGSISVLVFGWFLNFGIHLAAPTCILFLMGLTLTGAFNTISTLLVDLYPTQAAKATAANNFGRCLLGAGATALIDPMLSAMGRGWCFTFIALVMMATTPLLLIVIQKGPDWREERRLKEAAKKTVDGNAQEVRSDQGLFRDPMTIRKLHLSYRYPFRNLRPRNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W6PUA9</accession>
    <name>W6PUA9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major facilitator superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PROQFM164_S01g001150</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PUA9"/>
    <dbReference type="STRING" id="1365484.W6PUA9"/>
    <dbReference type="OMA" id="CAILMWK"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000064">
        <property type="entry name" value="MFS allantoate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF97">
        <property type="entry name" value="ALLANTOATE TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G14700)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="69"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="163"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="297"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="333"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="361"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="391"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="421"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="454"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="71"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM27341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="512" mass="57106" checksum="2B2728E518DD9191" modified="2014-04-16" version="1">MADEKHTNPPEIQLALDHEKAQEGEILEAQEKTNGKDVAAHFLAHLDPAIAVEPVTEAEARRVLWKIDLILIPLIMVTVVLAAIDKVIISNAAIYGMKTDTHLTGDQYSWVGSIFYFGYLAFEYPTALLIQRLPVAKLYVGMVLGWAILLLCTAATQNFGGLAAVRFLMGMTEAAVFPISSILTVMWWKTSEQPLRVAFWFNQLSSVFSGLISYGIGQTNTSVGPWRLLFLVLGGFSVLWSVVLYIFLPDSPVQCWYFSDREKFVCLERVKDNNTGMEDKTIKWYQVRECLLDPKTWLLALFSLAQNIPNGGLVTFSAIIVKGLGYSSLITTVLGIPTGVLATVWQIMLGFLAASVPNSRCTIIALANLVPMICAILMWKLPRENQHGLLAAYYVFYTYWAPYVLSTSLPMANTSGHSKKLTMNAIFFLAYCIGNIIGPQCFRSDDAPSYSRGYEGLLACLVVAIVAIISYGALCRWENYRRDKEAESNVEISEAAFSDLTDKEKRSFRYTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W6PUG2</accession>
    <name>W6PUG2_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Copper fist DNA-binding</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PROQFM164_S01g001336</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PUG2"/>
    <dbReference type="STRING" id="1365484.W6PUG2"/>
    <dbReference type="OrthoDB" id="4278067at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006878">
        <property type="term" value="P:intracellular copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.430.10:FF:000001">
        <property type="entry name" value="Copper fist DNA-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.430.10">
        <property type="entry name" value="Copper fist DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051763">
        <property type="entry name" value="Copper_Homeo_Regul"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001083">
        <property type="entry name" value="Cu_fist_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036395">
        <property type="entry name" value="Cu_fist_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28088:SF9">
        <property type="entry name" value="TRANSCRIPTION FACTOR GRISEA, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G13190)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28088">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR HAA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00649">
        <property type="entry name" value="Copper-fist"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00617">
        <property type="entry name" value="COPPERFIST"/>
    </dbReference>
    <dbReference type="SMART" id="SM01090">
        <property type="entry name" value="Copper-fist"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00412">
        <property type="entry name" value="Cu_FIST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57879">
        <property type="entry name" value="Zinc domain conserved in yeast copper-regulated transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50073">
        <property type="entry name" value="COPPER_FIST_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Copper-fist" evidence="8">
        <location>
            <begin position="5"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM27525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="93" mass="10392" checksum="B473B91BBB58A561" modified="2014-04-16" version="1">MPFDFQGCKWSCESCIRGHRSSKCAHYDRPMKRIPKVGRPLAKCSHVNGADCSCQEAWAIMVPLAPGSMVCRPESETQPVQQQQVDHVYAEGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W6PUR9</accession>
    <name>W6PUR9_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Dihydroorotate dehydrogenase (quinone), mitochondrial</fullName>
            <ecNumber evidence="5">1.3.5.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Dihydroorotate oxidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PROQFM164_S01g001327</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12 17">
            <text>(S)-dihydroorotate + a quinone = orotate + a quinol</text>
            <dbReference type="Rhea" id="RHEA:30187"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
            <dbReference type="ChEBI" id="CHEBI:30864"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.3.5.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; orotate from (S)-dihydroorotate (quinone route): step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.5.2" evidence="5"/>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PUR9"/>
    <dbReference type="STRING" id="1365484.W6PUR9"/>
    <dbReference type="OMA" id="IYGTDTR"/>
    <dbReference type="OrthoDB" id="14784at2759"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00946"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106430">
        <property type="term" value="F:dihydroorotate dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04738">
        <property type="entry name" value="DHOD_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000242">
        <property type="entry name" value="Dihydroorotate reductase PyrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050074">
        <property type="entry name" value="DHO_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005719">
        <property type="entry name" value="Dihydroorotate_DH_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005720">
        <property type="entry name" value="Dihydroorotate_DH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001295">
        <property type="entry name" value="Dihydroorotate_DH_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01036">
        <property type="entry name" value="pyrD_sub2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48109:SF4">
        <property type="entry name" value="DIHYDROOROTATE DEHYDROGENASE (QUINONE), MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48109">
        <property type="entry name" value="DIHYDROOROTATE DEHYDROGENASE (QUINONE), MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01180">
        <property type="entry name" value="DHO_dh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00911">
        <property type="entry name" value="DHODEHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0288">FMN</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="84"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="Dihydroorotate dehydrogenase catalytic" evidence="14">
        <location>
            <begin position="157"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="Dihydroorotate dehydrogenase catalytic" evidence="14">
        <location>
            <begin position="466"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CDM27516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="518" mass="55604" checksum="D9A70029ADAD56D1" modified="2014-04-16" version="1">MTCNSATMAWRASVRARALPTSRLIQRPSALLPKRAQRYPGALRYASDSAAPPPTEAAKEMGKEVTQEAAKEIPRKARRGSRKALYGASLALTLLVGYIYGTDTRASIHRYGVVPLIRLLWPDAEDAHHVGVENLKMLYQYGLHPRERGDPDSDGVLATEVFGYTLSNPIGISAGLDKHAEVPDALFDIGPAIVEVGGTTPLPQEGNPKPRVFRLPSQHAMINRYGLNSKGADHMAKVLKQRVADFAYAAGFGLHEQSAQRVLDGEANVPPGSLVPGKLLAVQVAKNKVTPDGDIEAIKRDYVYCVDRVAPYADILVVNVSSPNTPGLRDLQAAAPLTAILTAVVASAKNVERKTKPYVMVKVSPDEDSDEQISGICEAVWNSGVDGVIVGNTTNRRPDPVPRGFVLPAEEQKTLKETGGYSGPQLFNRSIALVARYRALLDQGPPSSATDSDKSVGKVSGLPRKVIFASGGITTGEEAREALKAGASVAMMYTGIVYGGVGTVTRVKQELREELQKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W6PUV2</accession>
    <name>W6PUV2_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid/polyamine transporter I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PROQFM164_S01g001819</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PUV2"/>
    <dbReference type="STRING" id="1365484.W6PUV2"/>
    <dbReference type="OMA" id="LSWWFIP"/>
    <dbReference type="OrthoDB" id="10054429at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF13">
        <property type="entry name" value="THIAMINE TRANSPORTER THI9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="71"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="193"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="241"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="280"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="320"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="383"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="408"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="449"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="479"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM28008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="518" mass="55832" checksum="91358D30BC0F881D" modified="2014-04-16" version="1">MDDLKNTEEFLAQEVNASDENTLERLGYKQVLNRSYSLFENFSTSFAALYFVGGVRVTFTTGIAAGGPLAYWTSYIITCVFTFITAAVIAEACSASPSAGSIYLWAAEAGGKRFGRLFGFVVAWWSTTAWTTFCASNTQSAVNYMLSELTVFNVDFPTDVSNIKFRAVQWICTEILLALAALMNLASARVFKYVFWFSTGAVFLDFILNVVWLPIGAHNTFGLRTAHEAFMTTYNGTGAPAGWNWCLSYLATAGILIGFDASGHVAEETKNAAVNAAKGIFWSTIVSGVLGFSAVILFLFTSPPIDVLFSYNAPQPFVPLYAALLGEGGHVFMNVLSVVALWLNTAIAITAASRLVFAVARDGVLPLSGWVSRVSNEGQPRNAVLVVWGVAAIITCTILPSGVAFTSLVSAAGVPSAAAYGLISLGRLTLTSGEKIEAKWSLGRLSKPFQLISVLWNGWVVAVLFSPYEFPVEASTLNYAPIIMAIVTIFALISWFFTPATAWVPRGRLSQPVADIAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W6PX42</accession>
    <name>W6PX42_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="7">TATA-box-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">tbpA</name>
        <name evidence="7" type="ORF">PROQFM164_S01g002589</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TBP family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PX42"/>
    <dbReference type="STRING" id="1365484.W6PX42"/>
    <dbReference type="OMA" id="FHFKIAE"/>
    <dbReference type="OrthoDB" id="2127950at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04516">
        <property type="entry name" value="TBP_eukaryotes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.10:FF:000001">
        <property type="entry name" value="TATA-box-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.10:FF:000002">
        <property type="entry name" value="TATA-box-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.10">
        <property type="entry name" value="TATA-Binding Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00408">
        <property type="entry name" value="TATA_bind_prot_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000814">
        <property type="entry name" value="TBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030491">
        <property type="entry name" value="TBP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012295">
        <property type="entry name" value="TBP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033710">
        <property type="entry name" value="TBP_eukaryotic"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10126">
        <property type="entry name" value="TATA-BOX BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00352">
        <property type="entry name" value="TBP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00686">
        <property type="entry name" value="TIFACTORIID"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55945">
        <property type="entry name" value="TATA-box binding protein-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00351">
        <property type="entry name" value="TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="21"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="52"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM28778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="264" mass="28340" checksum="DF24557D798A7959" modified="2014-04-16" version="1">MDSLTTHPSNAQQARAFTATSSLSFPGGAGDLTPPNSDKEALAMAQGGNGMNGQQAGANAIHGTGVTPASPATPAATPGATTGSSGIVPTLQNIVATVNLDCRLDLKTIALHARNAEYNPKRFAAVIMRIREPKTTALIFASGKMVVTGAKSEDDSKLASRKYARIIQKLGFNAKFTDFKIQNIVGSCDIKFPIRLEGLASRHHNFSSYEPELFPGLIYRMMKPKIVLLIFVSGKIVLTGAKVREEIYQAFELIYPVLSDFRKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2024-10-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>W6PXV3</accession>
    <name>W6PXV3_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S01g002889</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PXV3"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM29078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="62" mass="7095" checksum="84FD668EBCA549CD" modified="2014-04-16" version="1">MAQVCLNYLIGEEMKPRRNSRRRLSANLPAARVEFAAYAYTAYSYHLSRADPLVAVTFQLVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W6PYK0</accession>
    <name>W6PYK0_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lipopolysaccharide-modifying protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S01g002911</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PYK0"/>
    <dbReference type="OMA" id="CYWRELW"/>
    <dbReference type="OrthoDB" id="202415at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006598">
        <property type="entry name" value="CAP10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051091">
        <property type="entry name" value="O-Glucosyltr/Glycosyltrsf_90"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203:SF107">
        <property type="entry name" value="GLYCOSYL TRANSFERASE CAP10 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203">
        <property type="entry name" value="KDEL LYS-ASP-GLU-LEU CONTAINING - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05686">
        <property type="entry name" value="Glyco_transf_90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00672">
        <property type="entry name" value="CAP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase CAP10" evidence="2">
        <location>
            <begin position="190"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM29100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="462" mass="53032" checksum="AE965ECF0F4A78F3" modified="2014-04-16" version="1">MHQSWNKWCYRHYSLRRMISTVAIGACGVFIYLIWFGMNSDRDNVPQLLTQLIPAGHCTCQSSTSFQCADCLTCLASPPLLEPEHHETWSFQYGRDDQNLGLSQIQCQAAFPGLFQDIQRGVAYWKSQGSISRNDLSMVPFRDGMARAIISNGELYVVATRAKWDDHRRKILSTLGSIHRALSASSNRTSHPTIEFIFSIEDRVDDVDAASHPVWVLSRKASEESVILMPDFGYWSWAKSNIGPYGQVVQSIMAAESNMKFADKERKLVWRGKLSFAPKLRRTLLDIARGKPWGDVKELDWSKKVNFLSMEDHCRTMFIAHVEGRAYSASLKYRQACRSVIVAHKLQYIQHHHYLLVSSGPEQNYVEVERDFSDLPNLMDELLENPDKAERIANNSIKTFRERYLTPAAEACYWRALWEGWAEVSANVTRDVEPPVNRGLRYESFVLLDSNDMFKFDMSNSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W6PYT3</accession>
    <name>W6PYT3_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S01g002702</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PYT3"/>
    <dbReference type="OrthoDB" id="37659at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM28891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="49" mass="5220" checksum="2E7C121A5E45B3E7" modified="2014-04-16" version="1">MVTNSLSLMRVVESLAHHVAPKGLIGVMSSGQGSIGNNSERYIVVVKPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>W6PYX5</accession>
    <name>W6PYX5_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 9">Uracil-DNA glycosylase</fullName>
            <shortName evidence="7">UDG</shortName>
            <ecNumber evidence="7 9">3.2.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">ung1</name>
        <name evidence="7" type="synonym">UNG1</name>
        <name evidence="12" type="ORF">PROQFM164_S01g003032</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 9">Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 9">
            <text>Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil.</text>
            <dbReference type="EC" id="3.2.2.27"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 9">Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.27" evidence="7 9"/>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PYX5"/>
    <dbReference type="STRING" id="1365484.W6PYX5"/>
    <dbReference type="OMA" id="AGKKWFP"/>
    <dbReference type="OrthoDB" id="10031947at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004844">
        <property type="term" value="F:uracil DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097510">
        <property type="term" value="P:base-excision repair, AP site formation via deaminated base removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10027">
        <property type="entry name" value="UDG-F1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.470.10:FF:000007">
        <property type="entry name" value="Uracil-DNA glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.470.10">
        <property type="entry name" value="Uracil-DNA glycosylase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00148">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002043">
        <property type="entry name" value="UDG_fam1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018085">
        <property type="entry name" value="Ura-DNA_Glyclase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005122">
        <property type="entry name" value="Uracil-DNA_glycosylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003588">
        <property type="entry name" value="PRK05254.1-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003589">
        <property type="entry name" value="PRK05254.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003592">
        <property type="entry name" value="PRK05254.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00628">
        <property type="entry name" value="ung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11264">
        <property type="entry name" value="URACIL-DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11264:SF0">
        <property type="entry name" value="URACIL-DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03167">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00986">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00987">
        <property type="entry name" value="UreE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="Uracil-DNA glycosylase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00130">
        <property type="entry name" value="U_DNA_GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7 9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5 7 9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 7 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uracil-DNA glycosylase-like" evidence="11">
        <location>
            <begin position="119"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="309"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7 8">
        <location>
            <position position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDM29220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="362" mass="40429" checksum="85345CC5F8205349" modified="2014-04-16" version="1">MVSPVMKRKSEHLSAPDSKKPKGGSITAFFGAPKPKPASATSAPRPCSFDKAKWVASLTPEQRELLQLEIDTLDESWLAHLKDEVVSTEFLNLKRFLKKEKDSNIKVFPPEEDVYSWSRHTPLNKVKVVIIGQDPYHNHNQAHGLCFSVRAPVRAPPSLLNIYKGIKIDYPDFESPPDKGGLLIPWAERGVLMLNTCLTVRAHQANSHSNKGWEKFTQKVIDLVARVRTTGVVFLAWGRPAGNRVAKINKEKHCILQSVHPSPLSAHNGFFKNGHFKKCNDWLALRYGEDEIIDWSLVPSEKPLLPPCVSDKEDSTALVNHLPQPVKPEDVKAQPDNDDEFDDDDAIEALMSAEAEASSNTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W6PYZ7</accession>
    <name>W6PYZ7_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Serine/threonine-protein kinase ATG1</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Autophagy-related protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Serine/threonine-protein kinase atg1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PROQFM164_S01g003300</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Preautophagosomal structure membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PYZ7"/>
    <dbReference type="STRING" id="1365484.W6PYZ7"/>
    <dbReference type="OMA" id="CSMGDLY"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000693">
        <property type="entry name" value="Serine/threonine protein kinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045269">
        <property type="entry name" value="Atg1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348:SF22">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE UNC-51-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0072">Autophagy</keyword>
    <keyword evidence="8 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="21"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="395"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="451"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="407"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="492"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="529"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CDM29488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="642" mass="72186" checksum="6410EBFEA48B6FD5" modified="2014-04-16" version="1">MSTMECLKEEFVEGQLLDGRFRTVAPLNHGSFGMVFLATDTKTGQDVAIKRLIKASTNSGFEELECHRRFGFHPNLVNLIHTFNTDTHTYLVLEYCANGDLYEAIRLNRGPLETEHVRDFMLQLISAVDFMHANGLYHRDIKPENIFLTQDGSMKLGDFGLATKDSWCYEACVGSDRYMAPEQYEPTTTGYSPAKADIWSVGICLLNILFARNPFVTPTESDVLFADYVRDRQSLFDIFPNMSQDTYEILTHALTIDPSKRSLLDVRDSILRAVSFTTDDESLDEFCTEDREVVPASANREPLRTPSLQSPYVNQGDAFPWAKALQSTPPQAIRQLSAIPDNESYTEDLFPASEAAGTSWFSSRMESPSVASVLDSQLSESFVLLNLRKRDDLRKRAGPSLPRSDPVSITGSLPSHTTKPLPSLSMVFGNKGADKISKSWCDMWDEEESENEDLAVAQRREQNSRSWSQESQGAALPRLREPASASPNHRSHGPDVDLKMEPHVLGDLSLDEDSDSSASSSTPRPMRSSPHEPSRADKWSMLGEVRRQYKPEDELHKCKPRKSREVFGPKSVAANTRRHDWGRGTSGYHQGKSKPASPVEVRRRHLLEQQDWRSHVPSSFLPLDGSVDDDLDLVGGWHETHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2024-10-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>W6PZ07</accession>
    <name>W6PZ07_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S01g003315</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PZ07"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM29503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="259" mass="28651" checksum="030328BC41BF9220" modified="2014-04-16" version="1">MPQTFDPDLISRKGSPPSLFKEILFLSVSSVIGNAARFKRAVAQYMPSKLQLDFFVFDELYISFLFLRARFGDIGLRHNAQDPLIFGVKGLCDVQDLLDMIIGPCTDDSQDDAPGAFHVLFRQARDLDFEDIVAKSNARRIGAGKAHAFLRFFDQCGEVPTRGKGLGGEGSKLLSFLLILPRIPRLDGYFNPVVRASAKNNFGREPRADIALGWKAHSGDGLQYRAFSTGLIAADDDLRQLHKASNSDGAQLVNLVQQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q048</accession>
    <name>W6Q048_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Probable transposable element</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PROQFM164_S01g003472</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1365484.W6Q048"/>
    <dbReference type="OMA" id="GFDQVCK"/>
    <dbReference type="OrthoDB" id="1678912at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034647">
        <property type="term" value="F:histone H3K4me/H3K4me2/H3K4me3 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16100">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15518">
        <property type="entry name" value="PHD_Ecm5p_Lid2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.650:FF:000014">
        <property type="entry name" value="PHD transcription factor (Rum1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000322">
        <property type="entry name" value="PHD transcription factor (Rum1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.60">
        <property type="entry name" value="ARID DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001606">
        <property type="entry name" value="ARID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036431">
        <property type="entry name" value="ARID_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013637">
        <property type="entry name" value="Lys_sp_deMease-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004198">
        <property type="entry name" value="Znf_C5HC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10694">
        <property type="entry name" value="LYSINE-SPECIFIC DEMETHYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10694:SF33">
        <property type="entry name" value="LYSINE-SPECIFIC DEMETHYLASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01388">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02373">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08429">
        <property type="entry name" value="PLU-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02928">
        <property type="entry name" value="zf-C5HC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01014">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00501">
        <property type="entry name" value="BRIGHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46774">
        <property type="entry name" value="ARID-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51011">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ARID" evidence="11">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="10">
        <location>
            <begin position="309"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="JmjC" evidence="12">
        <location>
            <begin position="451"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="10">
        <location>
            <begin position="1177"/>
            <end position="1226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="102"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1145"/>
            <end position="1170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1323"/>
            <end position="1570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="170"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="203"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="300"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="1365"/>
            <end position="1374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1398"/>
            <end position="1409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1430"/>
            <end position="1460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1530"/>
            <end position="1544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDM29660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="1570" mass="176492" checksum="645FFA8B9E9BBD2F" modified="2014-04-16" version="1">MNYVDGLAMFHKQHGTNYSRLPSVDKRPLDLYKLKKAVESRGGFESVCKTKKWAEIGRDLGYSGKIMSSLSTSLKNSYQRYLQPYEEYLARAKPGVQQQLELEHGGPYTPSPLQSPMTHKPMLDENGTPSKIRDDTPSLPRMAASHTPMAFTPVAHSPMAHTPMEKSPEKPTPPIEPTPPPASRPAPTSFTPVNSGLGGFTAVNHSPFTPVNNGPPIKREGENGTLTPKVVSEHGFVSTPVNGQDEESLKRGISREASSQCENGDDDDGSGRRSKRPKKDSLPTVAGSHMSLLRPAPVKSRKDGSQPAGEKCETCGKSDDQGIILVCDGCELGYHKACLDPSTTTPSEHDWHCPKCLVGTGEFGFEDGGVYSLKQFQEKANEFKKKYFASKMPFDPVLNTHRRETEDDVEAEFWKLVVDLHETVEVEYGADIHSTTHGSGFPTIERNPLDPFSSDPWNLNVLPFYGDSLFRYIKSDISGMTVPWVYVGMCFSTFCWHNEDHYAYSANYQHFGATKTWYGIPGADAEAFEAAMRDAVPELFEGQPDLLFQLVTLMPPDKLRKAGVNVYALDQRAGQFVLTFPQAYHAGFNHGFNFNEAVNFAPADWEPYGAAGVDRLQNFRRHPCFSHDELLLTAAARDTTIATAKWLAPALARTCARELRDRAAFLYRQKEISARTPGFGPDSMADDVQPRFVVENEDLSEDDYQCQHCKAYAYLTQFRCHKSGKTVCLSHVDTYDCCGETLAQKLCGSGHTVRYRMGDEELQSLVQKVQERARIPEAWSEKLDKTLEDEPKPQLKALHNLLNEGEKIPYHLPGLQDLAAFVQRCDKWVEEANNYITRKQQNRKKNEKAWRRGSTKASQLDDRDREVRRIEHIYALQAEADKLSFDCPQMAVLEEKTREIEKFQQDINNALMHPHTRPLQEIEELIERGKNFNVEVPELEHLEQVSRQIKWIEQAVRKRDHYMTLTDCRELVAGAEQVGLSDTNEHLIHFKELARHGDAWEMKAKELMSVEAVHYQQLEALSAQASRFPVSPDTLAAVDAILTKQREAQKRIQTLYEKSKDPEMKNRPKYKDIRDLMESLEHMTSRPIGAIDLEREQKRHEDWMRKGKKLFGKANAPLHILRSHMEYVAKRNSYCFDLEDSYRPPVEPSSRDNSPEGLLENPSNPNNMWGPKSRKRDVFCICRHSEAGMMIECEVCHEWYHGKCLKIARGKVKEFDKYTCPICDWRQKIPRDAARPKLEDLQDWHAEIATLPFQPEEEEVLESIINQATAFRDFLHGFTNAACTTTEEVPTLIFYLRKIEGAEVLLTFETNFFRQEIHKWAPVAPEPPPILEQSLSTRKPRPTKQQKIMAQLGVNRPEDLPEHLRPKHIGVTKRKSVDAQSQAATGQSAPMQPPPPTSSSGQPPGTGPTLAQMADPNAAPYPFSANYSLPASDSTPAFAPTSSSAFLPHAAASQSPSFLPRSPPPQPDLEPSLFSPPRFGHDPQFASSSPRQNLDDVFADLTNQEIDPEAETQPMENTHANEALEALVVSNDSSRAASVQEESIQNGENGGPQGGPKLDGTNGGLEDEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q0F0</accession>
    <name>W6Q0F0_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nitrogen regulatory protein areA GATA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S02g000157</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q0F0"/>
    <dbReference type="STRING" id="1365484.W6Q0F0"/>
    <dbReference type="OMA" id="GVMMKRV"/>
    <dbReference type="OrthoDB" id="5563539at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042149">
        <property type="term" value="P:cellular response to glucose starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007039">
        <property type="term" value="P:protein catabolic process in the vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013860">
        <property type="entry name" value="AreA_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052292">
        <property type="entry name" value="Glucose_repression_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28051">
        <property type="entry name" value="PROTEIN MTL1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28051:SF1">
        <property type="entry name" value="PROTEIN MTL1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08550">
        <property type="entry name" value="GATA_AreA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitrogen regulatory protein areA GATA-like" evidence="2">
        <location>
            <begin position="154"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="296"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="363"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="414"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="363"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="416"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM30008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="521" mass="58347" checksum="C45D1FA6B3155B66" modified="2014-04-16" version="1">MTALLAPRETHSPFSDPVRCPASPTTQRYFLKDHAIPAKSPMQDDPHATDPPVASNLPSVLPSSNFAPITEQLAYPSTLNTLPSENELILPAYDTECFHNAKDPEDVSDVSTESHPFSWTSQPPSADDTLIEDEPSRHVDYLSHDWKEEDIWSSWRYVTSRRNDYSNGVRLENASWRTWAKAKHNLKTISPESLNWLKDCDVTWLYGPLKSSVERGTSPSPPPSYLETPTSYLDRKPILKKKTASEAILQRSLSQHTLLQHAGAILKAQEAENNWARPYFPRSNTDLDHLHHRTGSSTYSLGGTLTASSASGMTSPGERRHIHFNDEVVQCIAVEAKGYEDDWPATIGDESSSDDGVVFMRQISNRSSLSNRSTPRNSFSGDGKTIAPLPSTTLKYRGDPPELHTQTILDRWSPIPTRTLSPTPSVETLRPSRPSEPEANFLLDECEDPSLDFTGNYPDHDRAWFIEDTASDRTPRFTASGMIMPEGETETPSSSIYHRVVDTVNTARDIAHVIWNVGWRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q0L2</accession>
    <name>W6Q0L2_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S01g003618</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q0L2"/>
    <dbReference type="STRING" id="1365484.W6Q0L2"/>
    <dbReference type="OMA" id="IVATPCC"/>
    <dbReference type="OrthoDB" id="426718at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021838">
        <property type="entry name" value="DUF3431"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37490:SF2">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37490">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11913">
        <property type="entry name" value="DUF3431"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004881699" evidence="2">
        <location>
            <begin position="25"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM29805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="428" mass="49410" checksum="72A9C4088351ECE8" modified="2014-04-16" version="1">MRTLARAAIAIALILTLFWVKSHLESILQWRNDEYNSDLYVLNGDAYIELVSAHTATPATPSHTQTRRKWSPTARPTPRLMIANPEPERIPVDVPGAEWAGELWFRSEEEPEFYDSNGFDDAQLLAPVEHNDVMAPSSTAPSRPKVTPKSDRIIILGKMSYEDTDWLEDQLPEWQHAVYLVDDPEASLQVEQNKGKESSAYLQYILDNYDKLPEYMVFLHAHQYSGHVEFWEQDNVLTVQRLQLDYLRRVGYLNLRCDWSPGCPDEVQPFRQTAGRTTELAFAGAWIRIFNNTDVPEIVATPCCAQFAVTREQVLQRPRTAYESYHNWLMTTELDDETSGRVFEYIWHIIFGQDPVFCPEKAQCYKDVYAMDYEESAMNFFDDGIWGNWYDEAPMDEIPMDEIPIHPTPVKETPVHATPTHTTPVNRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q0Q2</accession>
    <name>W6Q0Q2_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycoside hydrolase/deacetylase, beta/alpha-barrel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g003358</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q0Q2"/>
    <dbReference type="STRING" id="1365484.W6Q0Q2"/>
    <dbReference type="OMA" id="GYLHEPM"/>
    <dbReference type="OrthoDB" id="3162524at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10938">
        <property type="entry name" value="CE4_HpPgdA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037950">
        <property type="entry name" value="PgdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47561">
        <property type="entry name" value="POLYSACCHARIDE DEACETYLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G05030)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47561:SF1">
        <property type="entry name" value="POLYSACCHARIDE DEACETYLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G05030)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NodB homology" evidence="1">
        <location>
            <begin position="25"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM29546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="308" mass="35427" checksum="D335CBCE9FC9E044" modified="2014-04-16" version="1">MAPKRVLITYGVDVDAVAGWLGSYGGEDSTNDISRGYWAGTVGTQRLLKLFKKYDIKSTWFIPGHSLETFPEDMAAVRDAGHEIGLHGYSHENPTDMSLEQQRDVLDKTYRMLTEFAGKPPRGSVAPWWETSKEGAQLLLDYGIEYDHSMSHEDCQAYYLRTGDTWTKIDYKQKAETWMKPLEHGSETGLVEIPSNWYIDDLPPMMFIKDAPNSHGYVNPRDIEDIWRDHFDYFYREYDEFIFPITIHPDVSGRPHVLLMHERLIEHFKKHEGVEFVTMEQVCDDFKNKNAPPPGALMPAKAGAMLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q146</accession>
    <name>W6Q146_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PROQFM164_S02g000397</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q146"/>
    <dbReference type="STRING" id="1365484.W6Q146"/>
    <dbReference type="OMA" id="DSSRWAH"/>
    <dbReference type="OrthoDB" id="2566866at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd03386">
        <property type="entry name" value="PAP2_Aur1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026841">
        <property type="entry name" value="Aur1/Ipt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052185">
        <property type="entry name" value="IPC_Synthase-Related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31310:SF10">
        <property type="entry name" value="INOSITOLPHOSPHOTRANSFERASE AUR1_IPT1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14378">
        <property type="entry name" value="PAP2_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="218"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="269"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="310"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="334"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="Inositolphosphotransferase Aur1/Ipt1" evidence="6">
        <location>
            <begin position="168"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="Inositolphosphotransferase Aur1/Ipt1" evidence="6">
        <location>
            <begin position="311"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM30248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="384" mass="43515" checksum="AC5B8888DFB48E58" modified="2014-04-16" version="1">MVPSTNFTQDTPDLGKPQLASHAWLEPIVVVGIMVGSLIVNRRRDSSKSSNESQYLGSYAILEEGDAYSIDNLQPKSETVCGINVKTGDSSRWAHHIHSRILQKLPFLVEMFYWSMNYLFYSVTKATAQWLSPAEIGVVEVARGHAIDILNFEHTTASWIFPINEADFQSFFIQNHPSILTIFNRIYSLIHIPGTVLFLSWYYYVAKNHASFATARRTMTLGNLAAFLVFCVYPLMPPRLLPDSYGFYDTVRQGNAESIWVGGKSVNQFAAMPSLHFTYAFVIGCTFLHHSGFLQRLQRRPTQKSYMTEFGFLALAILYPILVLSVIVATANHYWLDAVVAIFTVTLSYRFNKILILLLPLEYALCWCLRLAKPIPTTGDRVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q190</accession>
    <name>W6Q190_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Zn(2)-C6 fungal-type DNA-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PROQFM164_S01g001795</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q190"/>
    <dbReference type="STRING" id="1365484.W6Q190"/>
    <dbReference type="OMA" id="NSPLIEW"/>
    <dbReference type="OrthoDB" id="5297881at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF4">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="25"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="83"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="638"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="769"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="638"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="670"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="783"/>
            <end position="797"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM27984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="849" mass="93699" checksum="53DB347E725FA739" modified="2014-04-16" version="1">MSRPQVSIDRLTPRRATVEPRETMNCKSCRKRKIKCNRMRPSCEACKVFQCPCLYDAVPKKRGPKTDVLEALLKRVDGLEKRLHDEKNPISPTSPDTADDQPSFPARRNTVDASFNIYSSSDRSALPTSLPQHVDPFIRPTGHPAGLLQQPSPTNNGPLSDATLDLYFERLHGKPFYILDEATTRQLHQLNQLPPCLAMAISAMTVRYTTSPGQVEQSLRSGLDAALQARRMIEVDDPTVEGLQTLLLLSQAFHAYGLGKKAYMTFSNCVAMIVALDLYREAPSKPNISPAEREMRRRLFWSVYLMDRFISCGSRRPCLITDHSVVLRLPSWAPHAAGLNMEGELFHVGPNIQYSSDSRRKSPSAASLLIDITRILGVTNKYLAAGGVKGDSHFPWHALSNLSKIRQELDIWAAGTQDVFASIDSLFGHPESTTLLLSKLIYHLVHCLIYRPFLPIDLVELRGTGQHQSWQIEATNLCFSHSNAIAELVELGRNSPLIEWPAFVAYCVFTAGTVHVHGVHYKGREGEVFSSSAEFLTREMHQLAWLRNIWTGVQHQRELLQTIYTCHSELVRNLASSPMRFSPVFHLEHFLDRYPGLALDGSHVRLIDAGDDLAPSAASFIDHQDHYYQRPIATPSYHNPSPYFSNTRPGPSSPLPSSQASDIDRRNSHSHSLSQKPSHPTSLSPSIQFHTIQGNQQQQSSSVFSLPAGTDLSGPGTSENTHLSIPGFSPSSFGLSPPAYLTDASMHIAPTPPNPQYATFPFDTTHANPNGMTQAGPTALTPGGQSHTSGTHTTAGSENTSEKDPFLRLLEQLAENENSQGGPSELEFFLTGTGAEGDTAIPLEKDSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q1A9</accession>
    <name>W6Q1A9_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">EKC/KEOPS complex subunit BUD32</fullName>
            <ecNumber evidence="6">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13 14">Atypical Serine/threonine protein kinase BUD32</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">EKC/KEOPS complex subunit bud32</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PROQFM164_S02g000264</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. BUD32 has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit KAE1. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptional coactivators.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the EKC/KEOPS complex composed of at least BUD32, CGI121, GON7, KAE1 and PCC1; the whole complex dimerizes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Telomere</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DAMOX/DASOX family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="6"/>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q1A9"/>
    <dbReference type="STRING" id="1365484.W6Q1A9"/>
    <dbReference type="OrthoDB" id="2015447at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003884">
        <property type="term" value="F:D-amino-acid oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019478">
        <property type="term" value="P:D-amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023209">
        <property type="entry name" value="DAO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11530">
        <property type="entry name" value="D-AMINO ACID OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11530:SF26">
        <property type="entry name" value="FAD DEPENDENT OXIDOREDUCTASE SUPERFAMILY (AFU_ORTHOLOGUE AFUA_5G13940)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51971">
        <property type="entry name" value="Nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0158">Chromosome</keyword>
    <keyword evidence="10" id="KW-0274">FAD</keyword>
    <keyword evidence="9" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0779">Telomere</keyword>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="389"/>
            <end position="675"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00019973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00033194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CDM30115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="675" mass="74319" checksum="C3B8A4C462B358B8" modified="2014-04-16" version="1">MSQGHVIIVGAGVIGLSIAVKLSQYLKITVIARELPGDVGIDYASPWAGAHFRPTPAKTEEERREQAWMRQTYQEFEKIAKHHPEAGVDFIPAVEYFDTADATSFLAEENGYTTWPDFQILDPTQYPPQYPSIQLGVSYRSWVLNSPVYLKWLQTRAEAQGTRFIRANLTDLEQVVSVYRENTSQDEIDHVSAVVDASGRGFNDPDSFPSRGQFIIVSNHGDRTISHHWSDGSSTVIIPRPLGGGTVIGGTKEPNNWSEDIDDASTEVILKRVRILCPEMVDEQADGLAATNGFDVKQVYVARRPMRHGGLHFVLKPGNPLPLISCYGAGANGYKISWGLAGKVDEFFSGRPISENDSPTVAKNQALGESEENQAILPGRIGNPVIYEPSVGKALTHGSTSLIVRLKPGVIVKCPRYSWWHSDTADATSFVKDIKHSFEVEERLFDILGTHPSIVRYIGTSEEPRGLLFDEASDGNLQDYIDQHNDDIDLNLRLKWCCQAAEAVYYIHQKGVIHSDLRPDNFLLHSDSKSKLNLLLCDFGGSTNGGDIDGGHLPDPGFFNPSKPWVSTEAVDIFSLGSVFYTIMTGHWPYKSPGPFRSVAENNEYEERVDALFASQQYPSVDGLAGGAVIEGCWGDRYSDMASLIRDQSLSFGAMGASGNGYVSEAQGKGNHELS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q228</accession>
    <name>W6Q228_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Peptidase S10, serine carboxypeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S02g000195</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q228"/>
    <dbReference type="STRING" id="1365484.W6Q228"/>
    <dbReference type="OMA" id="LEYIHIC"/>
    <dbReference type="OrthoDB" id="373498at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035241">
        <property type="term" value="F:protein-arginine omega-N monomethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18090">
        <property type="entry name" value="Arginine_MT_Sfm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007364">
        <property type="entry name" value="SFM1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35517">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE SFM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35517:SF1">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE SFM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04252">
        <property type="entry name" value="SFM1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM30046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="204" mass="23194" checksum="CC2458983336E807" modified="2014-04-16" version="1">MTRPTFVVEHLDPELGPWSTLEYACIARESHDRGARFLLSSVPAELQMPADLAATKGLEVEQRSVEEIFADRKEKVCLLDPSAEAELSPEDGDTFEVFLFGGILGDDPPRDRTSELRKKGYVGRRLGPKQMTTDTAVRVTRLVVHEKVPLEDIQYVDYPELLINEHERTEMPFRYVKDANEQPIMPDGMVDLIKKDADKSIDFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q255</accession>
    <name>W6Q255_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S02g000534</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q255"/>
    <dbReference type="STRING" id="1365484.W6Q255"/>
    <dbReference type="OMA" id="FWHSKSN"/>
    <dbReference type="OrthoDB" id="5397330at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="182"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM30385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="226" mass="24834" checksum="A8C894D5AA0BA2BB" modified="2014-04-16" version="1">MPPFRNFLGRKSQPNEEPAPVDENYLSPNQRPAPIPIRNSQDEPTEYKLSVVNDSGVYLPPSPPERPSFWRRYPGSNKTINHRDLVDENEPFSISRESFDSYRRSFDISARSPIIHPDAGPSRTSLDSRFSRLTPSGTQSISLTKSGIMEEEAFEEVGLNDEKPKKKGFLSRFGDSSNDAQSSGSKSSTSSFGFHIPGRKRGQSGGGSELASVKATSFEPAPPGGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q2J0</accession>
    <name>W6Q2J0_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S01g002235</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q2J0"/>
    <dbReference type="OMA" id="PALMGMN"/>
    <dbReference type="OrthoDB" id="5398191at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="323"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="410"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="410"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="454"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM28424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="464" mass="51642" checksum="FD8EDC03BFD03CEF" modified="2014-04-16" version="1">MAMQYFNQIKHRRRSSQMITAPKPVLTPEDEAYLREVTAEPESVTPPTEQNKQTPTESPTGASLQPAISEPAENIPLPTSPGEEFAKELGEEGRQERKSSQQTLTRTETPKSEVSKPPPKKKRWSAMFWKKSTEKDKDTDDANKSQTEAGTPPTTSDKSTNGKNAEKDNDADDVTDILERLNLAADNNRVFSISEETQELLRKFKLIFKDLINGVPTAYHDLEMLLTNGNRQLQDTYTKLPSPMQKLIEKLPERWTETLAPEMLAVAADRAVKSGINVENVGKAAAVAEKMGVPSLKELVSKPAALVGMLRSIMAFLRARFPAVMGMNVLWSLALFILLFVLWYCHKRGREVRLENERLVTEEEIIKLNQDTSEGLIRPTETLTTTAPPGASSDEIRKGVIKVEEARAAPVESAVPAEVESETQQDTQQSTRPAVPTRSKSRLSMFGRAKTERMPSNVTPYPGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2024-10-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q2S8</accession>
    <name>W6Q2S8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S02g000785</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q2S8"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM30635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="80" mass="8449" checksum="93389478F56B1597" modified="2014-04-16" version="1">MPIAACSLPDGAQWCPRRASQTNPVVLLDPGSTLIHRDAEPGSELGNRLMSTAMSNGLYNIISTPGEYSVNPNPNPNACP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q2V9</accession>
    <name>W6Q2V9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S02g000460</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q2V9"/>
    <dbReference type="STRING" id="1365484.W6Q2V9"/>
    <dbReference type="OMA" id="DMSMRTW"/>
    <dbReference type="OrthoDB" id="4721035at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="123"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="701"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM30311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="835" mass="92599" checksum="ED91B727F6887B56" modified="2014-04-16" version="1">MASSWESQHSLLSEDSIDARPQRSWNPLNNRRTDSEYRYHPPSETTWSEEVLHEIGLGISSADAIPIELPGDNRHSTDSAATTTPYTYKIPQFSQTPTPQTPHAHSHVRCPNRGTVLQKRLSWVPLTVLVLAVYATVFSGIFLGIALRKPRWRNVSGDGPVAPSTATLLSSAFAKTIELSYVTICVAFLGQVLSRRALMRDSRGISISDMNMRAWIMQPGSMIVHWEALRYSALTFLGAIALVSTFVAMLYTTAAQALVAPKLTLGPIEPRLLEGKVTSSFANPKYIASDCATPVTNEMDPEYRNTTCIQIEHVGHAYHNYQQWITQWSEVVSSHNDTSNQLRKRPQPTGSLWDNTTITGSWIDIQDMSALSKKHGRMVNNITMAMPHGGIPAAAMNSKNKLKQPTDTSGEGKYNIEASVPSPAINVLCTGMTKDELKPLVYSTWPGGHKFNMTTWSTSPPDDIPRAPSWLNRTVVDSLFQFGPKYGQVPPVFGKYPLPYNTILNTTGPWPANAIYLLGATPPSNDSHMPEYVMCSMRGKQTGVCSTKYSADTSGAFLGTNCESASNDLQYDRRQDVFYEGEWNPDWKNIAAEWASALSLNSGISDGAASNARLLMQMMPQYNKKEGTFALDPTLPSIGEGLAVMAGSTLILSSQNAPFVPFWNYSIENNNVLPEPVYQVFNASIQAFGYASGPTEKWQGIFYVILVFAFLTSAICLGFMIFEARGRQVTDFTEPQNLFALAVNSPQTTQLKGACGCGPYGDQLKERWFIGMEEDDEHYYIRSKAEEKIPFVHKSMDSTHLEPMEIDDGGGRMLSPMVNEFRKVSKRHSFLARLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q340</accession>
    <name>W6Q340_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S02g000870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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            <begin position="1"/>
            <end position="186"/>
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        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
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    <feature type="compositionally biased region" description="Pro residues" evidence="1">
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            <begin position="15"/>
            <end position="27"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <begin position="30"/>
            <end position="41"/>
        </location>
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    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
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            <begin position="172"/>
            <end position="181"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM30720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="469" mass="52871" checksum="44CC80A35E0687A7" modified="2014-04-16" version="1">MIQSLPSPSLATPVQPQPTVEPTPLDRPSPSLNTLSGTIIQFSEHGRIATSTKETAFFPEDTEPQYLAKQVKLEPQDSVTKRKRSEDTDVNEDDKWDSEPPTSPEYNISIASDGGDSDTSDASSSPHAKRVKRAALHPSVKSGRSIKPKVGKTRRKKKKGTWDSDRSMSEPSDLDESEEEYIIPTGERDELLNNKLTRERAKRLLEAVELPQGHDLSPDEQRTAHQLLTRGCMPTIHRHWEKDFSTLPESLFFSGKDDEGQRNESNFILENDKCSEFYAIRAFQELLKICGNVRDYCNILDICPAIYIKKSIEKYLRWALSDAGVRVQPNTPPVHVIYRKPQDEEPKEAFNRVAKTLEDLSNTWQSQLAGPHDGEEAWPALMGLVLCGPVLSVISLDTNPNPQTLTHGIKFLGHFDLSDFDNDVWNTLAIAIIVMHIRRTVTKLAKAYYHRFVASIFDGPAMNFPDPDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q382</accession>
    <name>W6Q382_PENRF</name>
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        <submittedName>
            <fullName evidence="3">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">PROQFM164_S02g000580</name>
    </gene>
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        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
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            <taxon>Eurotiales</taxon>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="entry name" value="DUF7905"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25482">
        <property type="entry name" value="DUF7905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7905" evidence="2">
        <location>
            <begin position="466"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="203"/>
        </location>
    </feature>
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        <location>
            <begin position="774"/>
            <end position="809"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="164"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="783"/>
            <end position="807"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM30431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="841" mass="95725" checksum="6BE67F955B267613" modified="2014-04-16" version="1">MASLPEPHDKDWERTNAKSWELPYYGPGPDFGRGTIYDGDADQNTDNKSTDEDDEDAFEDINYDRPPVDYQLHPTSSKVAVTGRAISSVPPVPTPSPVPSQSTFQTRPVPTGSRTGRPQSPMGPVFNERGPNTGISNTLARPHYSACNLKPGQRTPVNRGQTDTPRPPFYSKKGSTTSTPSQHKARCPAISSGQNDSHSKAKWRKGFSPDGKYAHINLKSTINDQIASYRLPYECQVFQEKQVTLGEISNVDFRQRIIEETDAYMRMSAGNAKLVHIWGRQKQVLEAQNLLQDMVNRLMQQRTSPTVARWTKVHAHSNRKVAHARSQESHEERLSDMRKPPRITTDYTLAFLWPSDGPSLNHLITARRELLDSIRLRYDVNIYIKPGIPDYLFMSGNNERDMSIIASRFRELWERVMVQHETEIKLFLVAAPRAELMRTHVILQKSGRLSVPVICGPELAPDVTATWKTTADEIKLNNKNIVTTRLRKALHVIPQFRGFLQMRAKFGSFALQQWRKPNDGTSYEFSEFREMLTHMNTEGRLLPGIRLQQDEIFDRIMESTFLKPWGKAKIKSLLSLMPKYSANFEYQVNKDSVIRVEAKFSLPLGSQEFEVNGVRCFKSKQIGAPVDRQMPMQISMIDFERSDWQLEVKALELCPEKEISPELDKFMRSIAFQWNPSAKSIGSVPQRKARFSYGAPVKRFVEKATIQLQVKDSPHVFELARFDEYTYGVGHWSMTPKVSWGASLFNPSWDDILGEQADVKALDISKEGCLSVFFPPPGDEQEQTEKPKTDDELRKEAENRKMDEEKQLGSFMSTVQQVARMLGNPGAEMPDFLENDLGSLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q3N6</accession>
    <name>W6Q3N6_PENRF</name>
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        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">PROQFM164_S02g001090</name>
    </gene>
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        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q3N6"/>
    <dbReference type="OrthoDB" id="4526612at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM30940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="43" mass="4579" checksum="5BF8D780E80E1490" modified="2014-04-16" version="1">MLYVTSEICEEPRFAPDLRNGDHGCSCGSSCQCPAGACNCPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q4T6</accession>
    <name>W6Q4T6_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">dbp3</name>
        <name evidence="17" type="ORF">PROQFM164_S01g003016</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">ATP-dependent RNA helicase required for 60S ribosomal subunit synthesis. Involved in efficient pre-rRNA processing, predominantly at site A3, which is necessary for the normal formation of 25S and 5.8S rRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DEAD box helicase family. DDX5/DBP2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="3"/>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q4T6"/>
    <dbReference type="STRING" id="1365484.W6Q4T6"/>
    <dbReference type="OMA" id="RGKNAMD"/>
    <dbReference type="OrthoDB" id="196131at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00268">
        <property type="entry name" value="DEADc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044742">
        <property type="entry name" value="DEAD/DEAH_RhlB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 13 17" id="KW-0347">Helicase</keyword>
    <keyword evidence="7 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="15">
        <location>
            <begin position="117"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="16">
        <location>
            <begin position="322"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CDM29204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="451" mass="49390" checksum="EF4E0BE2C2E4DC28" modified="2014-04-16" version="1">MGKRSHLEPAEQRPKKKSKSEKSEKSEKPSKASKDKQENGDEKTAAYSDASALSDIPQSDIDAFLTENVIKVSDPSSPDATQFRPILSFDHLPKCDAGLYTQLKSFPAPTPIQSTTWPLLFAGRDVVGIAETGSGKTLGFGLPCLKKLIDSKSSKPCQPKAVVISPTRELAMQIYDQLVKFGGTEKTRVTCIYGGVGKDEQRRALQKAAIVVATPGRLKDLLNDGSIDLGKVTYLVLDEADRMLDKGFEQDIKDIVKQMPVSKRQTVMFTATWPRSVRDLAATFMKNPVTVTIGGDPSADPRANLRIKQVVEVVDGRDKESRLMQLLTKSQRGHQSPEKVLVFCLYKKEAMRIENLIRNKGFSVAGIHGDLNQSDRFRNLDAFKNGKATILVATDVAARGLDIPNVKLVINVTFPLTVEDYVHRIGRTGRAGADGLAITMFTETDKGLSGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q4U8</accession>
    <name>W6Q4U8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type DNA-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PROQFM164_S02g001829</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q4U8"/>
    <dbReference type="STRING" id="1365484.W6Q4U8"/>
    <dbReference type="OMA" id="IAGIWMN"/>
    <dbReference type="OrthoDB" id="5391043at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF23">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="40"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="692"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="967"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="696"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="714"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="735"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="765"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="978"/>
            <end position="991"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM31678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="1027" mass="113750" checksum="0AA103DB206D8B57" modified="2014-04-16" version="1">MADDLKDQLDIPADLTVGGSAGTSTGQGPRRLPKKRTKTGCLTCRKRRIKCGEEKPICTNCVKSKRICEGYAQRVVFKNPIGLFGSFNNGHSHDLQIDQQHMRGPMPNDYGSELPPQQAAAAAQHPMLAPRPADPAVMGYPSFPSQMHSSAQLQPINTPSFYYPAHVQPPSHMWHIQPIAQTENTLVPPNVTDFSQGQQSVQLDQTSALHTSHASVQNVPQIASPIGQTAEEYASNLSPMLASSSMHGRRESETNLVPQMTQPLPTIYHYQPPLGQLPQQLRSHEQYIPYQIPHQQQMIYMEDESEDYYDVDSDDEMVDQSQAEGFNQLSLIMASANRDEQQLRSFTTHLNEPNVLASYRPTLGSSPLNNPKTARIFAHFIHSTGPSLSIFERHPTDSSIVLGAAVPSAQQGLWVYTLALKALEHPALLQAILAVSSLHIAYLQQAPTTVSLKHYHYALKRVSSAVGLPLRRKQVGTLAATLLLGYYEVISADHSKWNNHLGGSTHLIREIDFAKTTRDLRAYRRRSHEQRRQSGWSNSWWGLSGVSEDDPFSEKEESIDEDLIGAIMGQAVNYDDFGGINEEGTLPSKKHFTRKDIEVFRIQCDLYWWYAKQDAFQSFIGGNKLLMPYSQWGQCPPRAGIGRLDAIYGSADHLWLLLARVTDFGFRDRKRKLRTLKAGGVNWRPGPGMFKFMGRFAGGPPGQRPGSSGGLGPGGPPGRPPGPPPGPPPGPPTEMSPSSSPGSTSAPSPPMYGMIPPQPPARLPRGFEDTPREPRLSPDEDDPAHDVSYNEAEQEWEEILVAMEILYQALGRDFQPLPTDVAPPISTPFGPALQYRTHTIAVIWGFYYAMRLLLNRIHPSMPPAIMVAAGVSAPTTAEFSQIVGKILAGVYYPQRFNLEAGSLNPNLGSSLTDMSVPLFFAAVQYSDPTQRAWTISTLRDISRLTGWKSADAIAGGCEKAWIAAAKQGRGPPYQQSFKTDRDREREQERQSEAVLHEVKDRRFVPVKSDRAHWAMGILEEDIANLEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q512</accession>
    <name>W6Q512_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DDHD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S02g001221</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q512"/>
    <dbReference type="STRING" id="1365484.W6Q512"/>
    <dbReference type="OMA" id="HSSYWIL"/>
    <dbReference type="OrthoDB" id="69269at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004620">
        <property type="term" value="F:phospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004177">
        <property type="entry name" value="DDHD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058055">
        <property type="entry name" value="PA-PLA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23509">
        <property type="entry name" value="PA-PL1 PHOSPHOLIPASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23509:SF6">
        <property type="entry name" value="PHOSPHOLIPASE C1020.13C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02862">
        <property type="entry name" value="DDHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01127">
        <property type="entry name" value="DDHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51043">
        <property type="entry name" value="DDHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDHD" evidence="2">
        <location>
            <begin position="745"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="417"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="264"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="417"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM31071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="970" mass="107255" checksum="2020F0F9B25EBA98" modified="2014-04-16" version="1">MAGPIHTYGPSCLLVDEEPDLTEFQSLQSPPEIRSHFFYISSLPIDDPLAPLPPPTSHGTSNERVPPTPFSARDNIALEEAWRDLREARKTKSANHRSRPNTSTGTPGIAVPSHESVSNVEHRKAASQEDPSLVGSRGSTLSNPPFFPDDLPSRSHKSSLTFATGSTGMRIHGLGKENRVGSALGDEFKHDTPRGISIDQKRVRSSSINEFNTPKTSSSPLETENVGEGDEVVGSLQADRSHDASMSGSPFIRAPVSQPQTPLGRSFESSSSREGGEWQAELRPSTAPRSAPKPSGLRTTVSLDQLTQDSEREMTEEPNKQSKIPVGVSRLHLVELPNLKMKPIYWSPLQDISSVVRATWFYKNTMLPVETELANKLEAGYVYLKPWSDTWQDELNSCVENGADAELKIVHPLWTKQDSQPSTAQVPQSSDSPLDEAEDPLRFDNNRAAGGTSIQSETIKSYLTSSAIYVDAKNAQVLRPSLLPSVSRGRRPLSAIRKGHQIGIPVVRGFSRKSWEHLHPSKSNPIDVRHYIRKTQSKSPSAQGEQICYACKMEESRPSPTDLVLVIHGIGQKLSERMESFHFTHAINAFRREVNMELNNEPVWPHVRQDHGGIMVLPVNWRTNLSLDDPDVESGIEDPASNNFSLADITPQTLPAIRSLISDVMLDIPYYLSHHKPKMVKAVIREANRVYRLWCKNNPGFQDSGRVHLIAHSLGSVMAVDILSYQPTHVPQFDFSNTALRSDIFEFDTGHLFLCGSPVGFFLLLNKASLLPRKGRDKPGSEGDDLLRGVAGEAGQYGCLAVDNLYNIMHTTDPIAYRVNATVDSGLSNSLKMGTIPSSTASFWQSFGSVFRWNSNPSTLLPSTAPARPAAVSKLPSNVELETHDFTREEIAEKRMLLLNDNGQIDYYLSGGGGPLNIQYLNMLSAHSSYWTLGDFVRFLVVEIARKQGREGTLLAFRAEKKKGWKYSKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q641</accession>
    <name>W6Q641_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">isopentenyl-diphosphate Delta-isomerase</fullName>
            <ecNumber evidence="4">5.3.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">IDI1</name>
        <name evidence="14" type="ORF">PROQFM164_S02g001621</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>isopentenyl diphosphate = dimethylallyl diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23284"/>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="EC" id="5.3.3.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:23285"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Isoprenoid biosynthesis; dimethylallyl diphosphate biosynthesis; dimethylallyl diphosphate from isopentenyl diphosphate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the IPP isomerase type 1 family.</text>
    </comment>
    <dbReference type="EC" id="5.3.3.2" evidence="4"/>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q641"/>
    <dbReference type="STRING" id="1365484.W6Q641"/>
    <dbReference type="OMA" id="KAPFDNG"/>
    <dbReference type="OrthoDB" id="510307at2759"/>
    <dbReference type="UniPathway" id="UPA00059">
        <property type="reaction ID" value="UER00104"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004452">
        <property type="term" value="F:isopentenyl-diphosphate delta-isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050992">
        <property type="term" value="P:dimethylallyl diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009240">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006694">
        <property type="term" value="P:steroid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02885">
        <property type="entry name" value="NUDIX_IPP_Isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000012">
        <property type="entry name" value="Isopentenyl-diphosphate Delta-isomerase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011876">
        <property type="entry name" value="IsopentenylPP_isomerase_typ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02150">
        <property type="entry name" value="IPP_isom_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10885">
        <property type="entry name" value="ISOPENTENYL-DIPHOSPHATE DELTA-ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10885:SF0">
        <property type="entry name" value="ISOPENTENYL-DIPHOSPHATE DELTA-ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018427">
        <property type="entry name" value="Isopntndiph_ism"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 14" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0752">Steroid biosynthesis</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="13">
        <location>
            <begin position="90"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDM31471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="270" mass="30653" checksum="4C2F905CB47BB1A7" modified="2014-04-16" version="1">MSATMTITSPPEITADNVATLFPEVDTSLAREVLPISQTNTARGSELEGYDEEQVRLMDEVCIVLDNNDRPIGSASKKICHLMTNIDKGLLHRAFSVFLFDSNKRLLLQQRATEKITFPDMWTNTCCSHPLGIPGETGAELDAAVLGVKRAAQRKLDHELGIKAEQVPLDKFEFFTRIHYKAPSDGKWGEHEVDYILFIQADVDLDPSPNEVRDTTYVSADELKAMFEQPGLTFTPWFKLICNSMLFEWWSHLGTPALEKYKNEREIRRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q6G0</accession>
    <name>W6Q6G0_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Sec20</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PROQFM164_S02g002424</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the SEC20 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q6G0"/>
    <dbReference type="STRING" id="1365484.W6Q6G0"/>
    <dbReference type="OMA" id="WYLETTF"/>
    <dbReference type="OrthoDB" id="46868at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005606">
        <property type="entry name" value="Sec20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056173">
        <property type="entry name" value="Sec20_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12825">
        <property type="entry name" value="BNIP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12825:SF0">
        <property type="entry name" value="VESICLE TRANSPORT PROTEIN SEC20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03908">
        <property type="entry name" value="Sec20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Sec20 C-terminal" evidence="11">
        <location>
            <begin position="160"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="340"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="340"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="358"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDM32273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="382" mass="42651" checksum="137C833A39233963" modified="2014-04-16" version="1">MSSTTALQGRVKELSASLGQIQPLVDRLRDFTASIGQGDEARLELGGEIHSRLKEAEQELELLRVEVEALETGSDSRRKSSAVHGQKEVEKERVVSMAGRLAEDLKRTRGDFRTAQLQAKRNAELARRKERDLLLSRSYSSEKKKPSEKFTQDDLVLNASNDVTSALRRTHQLMQAELSRSHFAQSTLEQSTAAISSLSESYSSLDTLLSSTRSLANSLLRSQKSDTWYLETAFYILLATIGWLLFRRVFYGPLWWLVWQPLKLFARLAFATGAAGLSTTAVQSASQSISRDVSTAIHQMATAATTGTVTASSTAWEQEPTAPIDSNRVIDKIGDMVEQERQKSVDIDDVTPEERARQAKLPRNTKKRMFEAGMEEPVRDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q7D6</accession>
    <name>W6Q7D6_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S02g002794</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q7D6"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM32643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="103" mass="10972" checksum="A26BC4FD43E27052" modified="2014-04-16" version="1">MSVDVSVNVSVNVSVDVSVDVSVDVSVDVSVDISVDVSVDMSIDVSVDVSVNVSVDVSVDATGRHYIVSGFVGSACFVVMYIFIHNADVSQFLYISDHTFNFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q7W6</accession>
    <name>W6Q7W6_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="7">C4-dicarboxylate transporter/malic acid transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PROQFM164_S02g002636</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q7W6"/>
    <dbReference type="STRING" id="1365484.W6Q7W6"/>
    <dbReference type="OMA" id="LPCREHR"/>
    <dbReference type="OrthoDB" id="2901184at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015140">
        <property type="term" value="F:malate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09317">
        <property type="entry name" value="TDT_Mae1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.150">
        <property type="entry name" value="Voltage-dependent anion channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030185">
        <property type="entry name" value="Mae1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004695">
        <property type="entry name" value="SLAC1/Mae1/Ssu1/TehA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038665">
        <property type="entry name" value="Voltage-dep_anion_channel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31162:SF0">
        <property type="entry name" value="MALIC ACID TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31162">
        <property type="entry name" value="MALIC ACID TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03595">
        <property type="entry name" value="SLAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="59"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="88"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="164"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="222"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="265"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="308"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="344"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="376"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="11"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM32485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="412" mass="45441" checksum="C6E6558001D721DF" modified="2014-04-16" version="1">MSNPVLLGVYPNHSQELQPPSAPPSAPPSAHSETPFMESEKYQKQYPLSFRDRLRHFTWAWYTLTMSAGGLALLIANQPNKFTGYHEIGLAIYLINLVLFSLVCSLMAARFIIHGGALNSLRHEREGLFFPTFWLSAATLITGLEKYFGENPAPSFTATLEVLFWIYCFCTFTLAVVQYSFVFTSHTYRLQTMMPSWILPAFPIMLSGTIASVIAKSQPARAAIPIVTAGMTFQGLGFCISFMMYSHYIGRLMESGLPCREHRPAMFICVGPPAFTALALVGMAQGLPATFNVMGSEDTTADGRMLEILALAAGAFLWALSFWFFCVAAIAVIRAPPTSFHLSWWAMVFPNTGFTIATITLGNAFDSSAIKGVGSAMTICIVCMFLFVFVNHGLAVYRQDIMYPGKDEDTSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q803</accession>
    <name>W6Q803_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S02g002277</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q803"/>
    <dbReference type="OMA" id="DISRYMA"/>
    <dbReference type="OrthoDB" id="4367264at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM32126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="376" mass="43152" checksum="C5F103C9B1C75405" modified="2014-04-16" version="1">MLPMYGRFGAAIVLPRPMRRQDSRQQTETLFADQIPTFDDISRYMAFSGTSGLLASCLFEGLWEPGIPCNLASQWLDPAMKEITPALFQRKQPLPVIWALSERRPNLASLWLGATITGLLPQIILVSMCFMPSIYLEGVAWTQSPQSFMDSPNHRLVKPYRNGQRVTIAREDEFRLLFLTDTLSEKYTVPPLCPYSPFGEVDIQNTSLEVRLHLACNHRLVYRSWEWQCQKRETLSDFGTPTDSQSLKKNLKHISLLSIWIVTGIACGSMFNKTLWTSSFTHTQRSSFTFLGSLATSCILPRSFKLVAYKHILNFRAWAARAISIFISKIRPHAIQQKEEKSLNDRLSRIATRNLFSWTLFIDGIRSEEKPLWKHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q8L8</accession>
    <name>W6Q8L8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Nucleotide-binding, alpha-beta plait</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PROQFM164_S02g002457</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q8L8"/>
    <dbReference type="STRING" id="1365484.W6Q8L8"/>
    <dbReference type="OMA" id="IKAHFAS"/>
    <dbReference type="OrthoDB" id="167718at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12400">
        <property type="entry name" value="RRM_Nop6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000376">
        <property type="entry name" value="Putative RNA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034228">
        <property type="entry name" value="Nop6_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236:SF51">
        <property type="entry name" value="NUCLEOLAR PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="179"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="259"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="19"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="45"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="57"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="125"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="136"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="267"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="312"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDM32306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="343" mass="38817" checksum="30829E23413628B2" modified="2014-04-16" version="1">MGDKRKLVQDEVVEPEGKKMKKEKKDKKDKKEKKEKRKSQEESEVVAPAETAAPAQEEVKEKKEKKDKKDKSEKKDKSEKKDKSDKKEKSDKKEKSEKKEKRKAEETDAEPAAPSEDAMDIDVIPAEKADSDKKEKKDKKKDKKEKKQKKEKTEPAAETEEEPTAESAEGEQAQKSSRFICFVGNLPYSANHESLSKHFEKNPPATIRVATKKEDPKKCRGFAFIEFDNYDRMKTCLKLYHHSNFDDGKYPPRRMNVELTAGGGGAKSEHRNAKIQAKNEKLNEERQRQAKDIQKDKRKHEKKAAPAGGSGANAANLDGAADNAGSAVNDQWAGLHPSRRGRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q8V2</accession>
    <name>W6Q8V2_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="7">UDP-glucuronosyl/UDP-glucosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PROQFM164_S02g003249</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM33098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q8V2"/>
    <dbReference type="STRING" id="1365484.W6Q8V2"/>
    <dbReference type="OMA" id="PAVWHIK"/>
    <dbReference type="OrthoDB" id="5835829at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016906">
        <property type="term" value="F:sterol 3-beta-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000100">
        <property type="entry name" value="Glycosyltransferase family 1 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000009">
        <property type="entry name" value="Sterol 3-beta-glucosyltransferase UGT80A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010610">
        <property type="entry name" value="EryCIII-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050426">
        <property type="entry name" value="Glycosyltransferase_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004276">
        <property type="entry name" value="GlycoTrans_28_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48050">
        <property type="entry name" value="STEROL 3-BETA-GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48050:SF13">
        <property type="entry name" value="STEROL 3-BETA-GLUCOSYLTRANSFERASE UGT80A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06722">
        <property type="entry name" value="EryCIII-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03033">
        <property type="entry name" value="Glyco_transf_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyltransferase family 28 N-terminal" evidence="5">
        <location>
            <begin position="107"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="Erythromycin biosynthesis protein CIII-like C-terminal" evidence="6">
        <location>
            <begin position="430"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="653"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="82"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="682"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="700"/>
            <end position="709"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF06722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM33098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="933" mass="102528" checksum="D5710CFBA59C1F5D" modified="2014-04-16" version="1">MDSASTTLRPRSSRHGSIRSEDWPGEVSVPISPHRERKHVSGEGRNAGVKVLNDGRVDIKINEHMPQLAGLLHRIQTTTRPPDLEGKPTPEPIPKDKGKDFPLKLNIVIQVIGSRGDIQPFIALGKELKACGHRVRLATHLYFRDFVLEGGLEFFSIGGDPEQLMAFMVENPSLLPAFSTIRSGAIQKRRREMKDIIYGCWRSCIETGDGTDMHQIKEDLWSDTVDYRRRPFVADAIIANPPSLGHVHCAQRLGIPLHLMFTMPWSPTQSFPHPLAVLHPQDCKPTVANLVSYSVVDMLIWEGLGDLVNSWRKKCLALDPLDSITAPSLPQRLGVPFSYLWSPALLPKPADWGDQIDICGFCVLPRKSNYKPPKEIEDFLKAGPTPLYVGFGSIVVQDQVKLTRIVFEAINLSGQRAIISKGWGNLGIDDADVPDNILIVGSIPHDWLFQHVSCVIHHGGAGTTAAGLALGRPTIIVPFFGDQQFWGGIVAMAGAGPMPVPYKQLTVEKLTDAIKTALLPSTQAKAQEIADKMRTESGVRDGVRSFHRHLNLKTLQCAICPTRPAVWHIKQTSIGLSAFAAAVLVEMGAIKPEDVALNRAEEYDTYRNPVGPISAGAQVLVGAIANFVTGIGEVPYDIVVDFVEAGRAIGHTRDRSGSSRFSFGKSRKSHDSSLDSDDDEYHEPAEYHGPAECHDGLGSNGNDLMNLDTNDSEKDHIRHNRMNHELPASAVGQKQGIPIDQKKLLSYIETPHGQGVIYEIRTHGSRMSKKLLKSILWLPTDLTLSLSKGFHNAPMLYHDRMVKDMPKVMGFRSGLAAAGTELRDGFYYGITGLVTQPQIGAKQQGAKGMIKGIGKGIGGVIFKPPAGLWGLFGYPLVGIRRQLQKSLGKNVELSIMASRIAQGIEDMRTSTADDRAEVARKWHILEEELHASY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q974</accession>
    <name>W6Q974_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S02g003106</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q974"/>
    <dbReference type="OrthoDB" id="4355369at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM32955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="94" mass="10182" checksum="44ACC0D1C66F6978" modified="2014-04-16" version="1">MGRTGCILSEDLLITIVGRACSKSCIYDLLLLGECSNSDIQRLQSDKAWLEEVAAQKIQTIQGLNETVGVVSIKVQARKAGLKLVTEALETFKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q9J4</accession>
    <name>W6Q9J4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g000251</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q9J4"/>
    <dbReference type="STRING" id="1365484.W6Q9J4"/>
    <dbReference type="OMA" id="LYIHSRT"/>
    <dbReference type="OrthoDB" id="438224at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.330:FF:000033">
        <property type="entry name" value="Clavaminate synthase-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48420">
        <property type="entry name" value="NON-HAEM DIOXYGENASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48420:SF1">
        <property type="entry name" value="NON-HAEM DIOXYGENASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM26442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="352" mass="37997" checksum="7D2D27E6ADFBA9D3" modified="2014-04-16" version="1">METNTAEAVTVSLHELVDGTVSFDTLTKAFGPSSLGIIVVKDLPSTFSDLRTKVLSNASYLAALPDPELETLTSPESKYLVGWSCGKETLKSGHFDTLKGSYYVNCAFYQDASLDSAPADDFPDLPQYTAPNIWPPPAKLPEFRGSVESLCGLIIDTAALVAKACDRYAEANIEGYKPGYLHHVVTTSLTTKARLLHYFPNQEEEVETSDDDWCATHLDHGCLTGLTSAMFLDEAASPPSLDPSGSASAPLPELPHSPDPSAGLYIRSRTDEIVKVNIPKDCLAFQTGEALQLITHGKFMAVPHFVKGAKASPGQKIARNTLAVFTQPNLAEEVQPGLSFAEFARGVVQKNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q9N6</accession>
    <name>W6Q9N6_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S02g001054</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q9N6"/>
    <dbReference type="STRING" id="1365484.W6Q9N6"/>
    <dbReference type="OrthoDB" id="4155294at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM30904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="180" mass="20234" checksum="A54D7A8C84D53C3A" modified="2014-04-16" version="1">MPMDDSQYTTLRLGVMVSSKFRRRINAFPFDKNVYHPSLSGAIIGKFTTGLTHTDITLMKLGDGVDFVNEPFGNTSTLASPFRLGDFIRMAETKRQDLVFLDSPFTGLVEGKLMSKISCVFHLTTKIRKYGSKPNGTKWGKTQLMSWWTVLMAPPSGIPIIEFWAFSVMPLEQDSTRIIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q9R3</accession>
    <name>W6Q9R3_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PROQFM164_S02g003302</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM33150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q9R3"/>
    <dbReference type="STRING" id="1365484.W6Q9R3"/>
    <dbReference type="OMA" id="IGVFGQC"/>
    <dbReference type="OrthoDB" id="444631at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF162">
        <property type="entry name" value="SATRATOXIN BIOSYNTHESIS SC1 CLUSTER PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="40"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="159"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="75"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="251"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="251"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="270"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM33150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="400" mass="44512" checksum="73E1F6FA5E3D319A" modified="2014-04-16" version="1">MTMEILPTPQGMGTELSMTGLIAITWTGTGVSILFTSARIAIRIVYTLQAPHIYYIVFNMTGPDIVDHGLRYTHYEFAIIGIFWSVLWSVKASFLALFWMISNGLPRYRRVWWATVVFAALAYIGCWIGSVYTCHPPSNYFKFGKCSKPIDQRGSVISISYSTAVDILTDLLIMSLPLRIIWHGKINMQQKIGLGIVFCLGIIVIAAAIIRAVAITGKAYSDQAALAVWSVVESSISIIVGSLPPFRSIISTKPDSKQSPSSSSGVTPNFHDRNHSTRGEHRSDIASWNESPLSLHDLGNINYVMCAQGVYISGGQRARGLNNVPSASQEALKGDIKIIQEFVGSKAATLNITIRKHQRKTNDGPLGNKQRFEYNFALRYSHTHRVERYPDHNHHRDRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W6QA73</accession>
    <name>W6QA73_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S03</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S03g000292</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QA73"/>
    <dbReference type="OMA" id="NATDMPR"/>
    <dbReference type="OrthoDB" id="5416172at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM33568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="129" mass="13871" checksum="025572365610FE06" modified="2014-04-16" version="1">MAQQNPHQGGSLSEMAAQGTRIPNDAGMMNTIPSVPRPDQRAEHFGFDNGGIAEPSTAMAADNTTDLPRSTRDVGQTGEVISGTGNSMPAGIEAKHAYMGSNNHAGHGDTRDLKHSKYNRSEFERYQEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W6QAM3</accession>
    <name>W6QAM3_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Alcohol dehydrogenase superfamily, zinc-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PROQFM164_S02g003232</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM33081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QAM3"/>
    <dbReference type="STRING" id="1365484.W6QAM3"/>
    <dbReference type="OMA" id="GCAPDME"/>
    <dbReference type="OrthoDB" id="1560166at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940:SF7">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE-LIKE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="7">
        <location>
            <begin position="33"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="6">
        <location>
            <begin position="193"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM33081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="355" mass="38112" checksum="4962E5483433AFA3" modified="2014-04-16" version="1">MASSLPKTYRAIQCAAPQSTWDVITLELRDPAPTEVLVRVHASGICNSDHFVKDGAWPGLQYPRIPGHEIIGRIAGVGSELLQSPVNKERFAIGALVGVGWNGGYCNQCDYCRKGQFWTCRNVDYTGFTIDGGHGEYMYAPYTAIIDIAEDVLKTASYAELAPLCCAGATVFDAINTSKWSPGDICLVQGVGGLGHLAIQYANRLGLKVYAVSSGSSKRDLALSLGACEYIDSSKIDVVEYMSSLGGANLILCTAPYSKAINAIIPAVTKNGTITLVSAATDGPIQVDNLLLNMNRATLRGFACGCAPDMEKCIEYSATNNVKAMIKVFTMDEFTQAYNGVMDSTAKFRHVIVFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>W6QB86</accession>
    <name>W6QB86_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S03</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S03g000005</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QB86"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM33281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="86" mass="9532" checksum="82068F8896790CC3" modified="2014-04-16" version="1">MDSGLFSRSQQSSVTPFSFLPPNDPAILETRLPFFPNGASEALVADRSAYHHNVHCSLDSSDTRVSWPSRFFELSQSRNAMRAASV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>W6QBJ8</accession>
    <name>W6QBJ8_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">beta-glucosidase</fullName>
            <ecNumber evidence="4 12">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PROQFM164_S03g000549</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Glycan metabolism; cellulose degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="4 12"/>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QBJ8"/>
    <dbReference type="STRING" id="1365484.W6QBJ8"/>
    <dbReference type="OMA" id="YYPSPWA"/>
    <dbReference type="OrthoDB" id="416222at2759"/>
    <dbReference type="UniPathway" id="UPA00696"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.300:FF:000002">
        <property type="entry name" value="Probable beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1700:FF:000003">
        <property type="entry name" value="Probable beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050288">
        <property type="entry name" value="Cellulose_deg_GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019800">
        <property type="entry name" value="Glyco_hydro_3_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715:SF29">
        <property type="entry name" value="BETA-GLUCOSIDASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00775">
        <property type="entry name" value="GLYCOSYL_HYDROL_F3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 12 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11 12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004881431" description="beta-glucosidase" evidence="14">
        <location>
            <begin position="19"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type III-like" evidence="15">
        <location>
            <begin position="784"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="724"/>
            <end position="758"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CDM33825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="865" mass="94315" checksum="EC3C589FB3C21654" modified="2014-04-16" version="1">MKLAWFEVAALSASVTSASSLAYSPPYYPSPWMTGEGEWSEAYTRAVEFVSNLTLAEKVNLTTGTGWEQERCVGETGSIPRLGMWGMCMQDSPLGVRSSDYTSGFPSGVNVAAAWDKRLAYQRGVAMGEEHRDKGVDVQLGPVAGPLGKNPDGGRNWEGFSPDPVLTGVMMAETIKGMQDAGIIACAKHFIGNEQEHFRQPGEAQGFGYNISQSMSSNIDDKTMHELYLWPFVDSIRAGVGSVMCSYNQINNSYSCANSYSLNKLLKGELGFQGFVMSDWGAHHSGVESALAGLDMSMPGDVILGSPYSYWATNLTISVLNGTVPEWRLDDMAVRIMSAYYKVGRDRFRTPPNFSSWTRDEYNFEHSMVSEGWGKVNEHVNVQRDHAQIIRKIGSDSIVLLKNKAGALPLTHNERFIGIIGEDAGSNAYGANGCSDRGCDNGTLAMGWGSGTANFPYLITPEQAIQNEVLEYSNGQTNVFAVTDNWALTEMAALASQADVALVFVNADAGEGYISVDGNEGDRKNLTLWKNGEEIIKAASQHCNNTIVVIHSTSAVLISDWYDNVNITAIVWAGLPGQESGRSLVDVLYGRVNPGGKTPFTWGKTRKDYGPPILTVPNNGVDAPQVNFEDGVFIDYRRFDKDNTEPIYEFGYGLSYTNFAFSDLKVTPLASSEQREYKATTGKSQKAPVLGEAGKVLDNLFPEGITRVRQYLYPWLNSTDLRASSGDPDYGMDSKDYLPEGATDDSPQDLLPSSGSSGGNPGLFKDLYQVTATITNTGPVTGDEVPQLYVSLGGDDNPSKVLRQFDRVTIAPGQTLQWTTTLTRRDVSNWDVASQNWVISDAQKKVYVGNSSRKLPLSADLPSVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W6QC10</accession>
    <name>W6QC10_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Splicing factor Cactin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PROQFM164_S03g000325</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CACTIN family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QC10"/>
    <dbReference type="STRING" id="1365484.W6QC10"/>
    <dbReference type="OMA" id="HIDFWND"/>
    <dbReference type="OrthoDB" id="265955at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019134">
        <property type="entry name" value="Cactin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018816">
        <property type="entry name" value="Cactin_central"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21737">
        <property type="entry name" value="POLYGLUTAMINE BINDING PROTEIN 1/MARVEL MEMBRANE-ASSOCIATING DOMAIN CONTAINING 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21737:SF4">
        <property type="entry name" value="SPLICING FACTOR CACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10312">
        <property type="entry name" value="Cactin_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09732">
        <property type="entry name" value="CactinC_cactus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01050">
        <property type="entry name" value="CactinC_cactus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Splicing factor cactin central" evidence="5">
        <location>
            <begin position="70"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="Splicing factor Cactin C-terminal" evidence="4">
        <location>
            <begin position="417"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="49"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00034534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF09732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDM33601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="554" mass="64689" checksum="C18E9B3CD33F7AE6" modified="2014-04-16" version="1">MSARFPNRSDSKRSRSRSPSSWGQPQKYPRRDDGEWRNQQDSDRRWNNERSGPSQQPRNMRDQVRLNLIQEDQQEREWVAQEDVFVLKQAKKKAEIRVKEGRAKPIDWLTVTLRIIDPTRDPLDDEIADSDLDVVDPDGVFEGLSQTQLQDLEKDIDTFVNLETNAKNREFWQTMKVICRDRQKTITPESRALNSVAADINKLLSPKSYEQLQNLEVQVKRKLNSNEPIDTDYWEELLRSLAVWKARASLKNVYQAIIDERVRDLRRQQRQEAESIREKLAPLAPVVTADDTTNPDEFEGLDPDPMLQIRPEDKGLETMDESVFLNQVARERQKIIRMGFVPLRHRAAEKSSAIVSNPTSTNAPTTSVSTRFSSIPNEDFSQATRALYERELAKGVSENEEIFTGEEAVSTSSQSQWAGKHRPRKPRYFNRVQMGYEWNKYNQTHYDHDNPPPKVVQGYKFNIFYPDLIDKTKAPTYRIERENGRKRGESSAEAGEEDSCLIRFMAGPPYEDLAFRIVDKEWDYSAKRERGFKSTFDKGILQLHFQFKRIYYRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W6QC62</accession>
    <name>W6QC62_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type DNA-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PROQFM164_S03g000784</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
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        </subcellularLocation>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="InterPro"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
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        <property type="entry name" value="Fun_TF"/>
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        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
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        <property type="entry name" value="Zn2Cys6_DnaBD"/>
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        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zn_clus"/>
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        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
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        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3 8" id="KW-0238">DNA-binding</keyword>
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    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="144"/>
            <end position="172"/>
        </location>
    </feature>
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        <location>
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            <end position="25"/>
        </location>
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            <end position="72"/>
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            <end position="16"/>
        </location>
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            <begin position="38"/>
            <end position="51"/>
        </location>
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        <location>
            <begin position="116"/>
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        </location>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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        </source>
    </evidence>
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    </evidence>
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    </evidence>
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            <dbReference type="PROSITE" id="PS50048"/>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="589" mass="67062" checksum="C68168C7D1ADCBB8" modified="2014-04-16" version="1">MHTSFFTHQDLNGSEVQENHRSDIPISSLGVRGSVIRGSTSSASTGISTDDASVDSLDWNSEHSPEQDQPLKGYSQFDAQLNDIMELPKVEEVEELGDDLLNIKQADVESGAPAVPRKRGRPRKHPLPAPGGQAKVTKGRSKTGCITCRRRKKKCDETKPSCQNCQKNAVVCEGYPLKEIWKSGRQRVADARSQSLTAVPRSLPLLIDGIETDVDRRFLDHFVYGFSRVLTLINDDSNPFKEILLPMATQHRGLMHSLMCLSGSHLSGLDPEPKLKERKYFHFHRAIQDLKDNINASSSAQSPNEEDRLLVEDPIIASTIALSLNTICEGETNGEYRPHVDAARYLLLSQQPRNEKFRQFIVEFFQYHDVSNSLTSLDRRPNLLHPELHMPNFVPGVSAGMFLGVFDGLFNYISEITQLRDRIRERFNEGYEPAVDYQTLSEAVSIDMAIRNWETSHEPDTPNWCLAQLYRQSTWVYLYRTIRPSRPSDKIAQVVNDGLDYLDQLPQDASAFSIVLMPLFLLGCSAFVPEQRRRITQGFENLKSYSNLRNIEPAFKVVVRVWDIMDTRMQDSWDWEKIIRDMNMDFLIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W6QCB0</accession>
    <name>W6QCB0_PENRF</name>
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        <submittedName>
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    </protein>
    <gene>
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    <organism evidence="8 9">
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
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            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
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    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="1365484.W6QCB0"/>
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    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="MFS"/>
    </dbReference>
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        <property type="entry name" value="MFS_dom"/>
    </dbReference>
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        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF138">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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            <end position="130"/>
        </location>
    </feature>
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        </location>
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        </location>
    </feature>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="256"/>
        </location>
    </feature>
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        </location>
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    </feature>
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        </location>
    </feature>
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        </location>
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        <location>
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        </location>
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        </location>
    </feature>
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            <begin position="1"/>
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        </location>
    </feature>
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            <begin position="7"/>
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        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM34303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="558" mass="61384" checksum="2F69AFFBC2DECFE8" modified="2014-04-16" version="1">MECLNQHPDKYEPDIDFPIDSHSHRSDDTIEEIDPLELTRINTYRLQQKTTVGSTRGPTPRDKWLPMGANKDYPPLLPDSEDYVVEFDGANDPLHPYNWSTSRRIMLVCILCYGTFAGSFTSAVFSAAISGLSKEFNTSAEVGSLGVTLYVLGFAAGPTIWAPGSELIGRRWPLSLGLFGCAIFTIACAVAKDLQTIMICRFFAGLFSASPISVVPAVFADLFNNTQRGVVMSIFCMAVFIGPFSAPFVGGFIAMSSLGWRWIMYISAIMVFLGFVLVFVFLEETYAPVILVRKAATLRRQTRNWGIHAKQDEVEVDLKELLRNNFARPIVMLVKEPILLLVSLYISFVYGLMYALLGAYPVVFQGVYGMSSGVGGLAFIGIIIGELLGGVYILMIQSSYKTKLAANGDKPIPEWRLPAAIIGAVSFAGGMFWFGWTGYTSSIHWMAPVASGLLTGAGIFLIFLQCFNYIVDCYPSLAASTIAANTILRSAIGCSFPLFSRQMMENLGVQWAGTMLGCIAVVMIPIPVLFKVYGPWLRERSKLACSPVFDVEKKPYDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W6QCY7</accession>
    <name>W6QCY7_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g001278</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QCY7"/>
    <dbReference type="OMA" id="YSWLSVK"/>
    <dbReference type="OrthoDB" id="4414363at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="222"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="292"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="229"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM27467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="317" mass="35357" checksum="3548144136A1D85F" modified="2014-04-16" version="1">MASIDFASARGTKLNDIVVDHRPSTGRGKKLTLAQEGVLKRLYEQKLPAVSNGELPAKKFWLDVASRFHEETGREYSWLSVKRRAAGWRQKSPEVDQRLDASHASKLGIEDLVIEPNHQDISHQSLSEQNSYVRKQLTLSQKPSLHPRGSNTLGLSQIERSPGVTEPTQDTSRNLESLLISQPRTRSTSPQRVSQPKYRHRSPSTMRRTKLVSKRLHHQLASPADGIVDSGPDPLSDSSGAYENVQPIYPGKRNPAGFNRIRESVEQNEPEKNARNSAISKHGVNKVSNRLLASPGLSGQDDLPLAPTRIMRRRVAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W6QDN2</accession>
    <name>W6QDN2_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Zinc finger, U1-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PROQFM164_S03g001525</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QDN2"/>
    <dbReference type="STRING" id="1365484.W6QDN2"/>
    <dbReference type="OMA" id="VDHRRKW"/>
    <dbReference type="OrthoDB" id="30343at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040107">
        <property type="entry name" value="Snu23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022755">
        <property type="entry name" value="Znf_C2H2_jaz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45986">
        <property type="entry name" value="ZINC FINGER MATRIN-TYPE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45986:SF1">
        <property type="entry name" value="ZINC FINGER MATRIN-TYPE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12171">
        <property type="entry name" value="zf-C2H2_jaz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="101"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="178"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="185"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM34798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="213" mass="24559" checksum="87F7169C9E75CBC2" modified="2014-04-16" version="1">MSGPNSYGTPVSDTAFRKTWDREEYAKKAADDEAKRKAEGKARYEAKLLGKKYHAPVDYSSLEDTTARNQRLDVASMVGKTMIVPAGSGMGKRGLGAGFYCKDCDLTYKDNLQLVEHLNSKQHLIATGQSGEVKRANVEDVRLRLRMLSHRKRQRDEEERKAWQLDLGVRLKEREEIDAKEREEKRRKRTEKRKKEKVKKEDDSWEGRLGIIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W6QDP5</accession>
    <name>W6QDP5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S03</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S03g000925</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QDP5"/>
    <dbReference type="STRING" id="1365484.W6QDP5"/>
    <dbReference type="OrthoDB" id="5979581at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM34201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="49" mass="5572" checksum="57FC713F927342CD" modified="2014-04-16" version="1">MGRGETEQTCQWDVAGGELRALEDFLRAMMTFEPAERPRRTNSSGPSIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W6QE85</accession>
    <name>W6QE85_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PROQFM164_S02g002665</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the putative lipase ROG1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QE85"/>
    <dbReference type="OMA" id="CEEYETH"/>
    <dbReference type="OrthoDB" id="5086500at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007751">
        <property type="entry name" value="DUF676_lipase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052374">
        <property type="entry name" value="SERAC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48182">
        <property type="entry name" value="PROTEIN SERAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48182:SF2">
        <property type="entry name" value="PROTEIN SERAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05057">
        <property type="entry name" value="DUF676"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF676" evidence="8">
        <location>
            <begin position="30"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM32514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="230" mass="25791" checksum="053B3521529F42DA" modified="2014-04-16" version="1">MSRNKEFPKQIYGIQELYRSCGEPVEVDIVAVHGLNGHATGSWTSKPQEICWLSNASFLPRYIPRARVLVWGYNASIFSQNGKAPSADRVLQHAQTLVSQLEADRDLEDAAKRPIIFVCHSLGGIIVKRALAYAESRVRLTHIYSIYVCTFAILFFGTPHQGSSKANILSSLQKIVSIATPKAAIDLESGLVNALEKESEVLQNITDQFTPLMSNFRVFFFWEQEKTDLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W6QEI3</accession>
    <name>W6QEI3_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S02g002765</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QEI3"/>
    <dbReference type="OMA" id="KPLLHHN"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM32614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="210" mass="23264" checksum="EFE62CBD232982AA" modified="2014-04-16" version="1">MPVCQCIYSDRLAFMPRLIVILISSHQPFKPRLAKFLSSKGFSPIEVVCGLTRGPVTPRRTKQLSLRRIIGYCFIAIIPVLICIVIVTSKLKAPRRVRCESSRSDLINRSPSTPASYRRSRRKTLSRTDLDEIPIYRTGDFPGSRKRGGTPDVERGITCQQTSSSPDLADQNLTLSRLDSSVSGSKIKNEGANSGYTPLPAKPLLHHNTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>W6QEL5</accession>
    <name>W6QEL5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PROQFM164_S03g001637</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QEL5"/>
    <dbReference type="STRING" id="1365484.W6QEL5"/>
    <dbReference type="OMA" id="RTVYHTN"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00302">
        <property type="entry name" value="cytochrome_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000090">
        <property type="entry name" value="Cytochrome P450 monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF87">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE ALND-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="491"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM34910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="552" mass="62292" checksum="48BF04FB0EC87059" modified="2014-04-16" version="1">MVAKNFHLLGEAITSARPIEVETTVDYEELQHLIAGQFAIVEPSGIGFQSEDSILSTPSEILTNEGPIAISIDGKAVREIPGPKGLPFVGNFFEIYPDHLGNHQRLFEQYGPIIQTTNMGRTVYHTNDPALSAIVFAESDFFTKKINEAHPLYPIKNQQAGVFLGDTDTPEWRAAHKFLPPALGPKAVRHYAPTMQATVEDSFNVFDELDERGEAWNVYPYMLKLGAQAVGKLVLGMDFKHFSAVDAPPHELVYRIAESLELNKKVTARGDWYAKLPFGDPQRLRDARYRIIEMVNESIQNASRNGIEDLPLQDAALQASNMIDYIIRATDNKGEKLPKTSLMEALVVATGAGFTTTSSLLSWLLYSVVSYPGMQERLLQELIDNDIDADTPMTADLTDRLAFLDKFIKETQRRHNPSYQPARTAKVDMILPGGYKLSEESIIIPALHHIHNNPAVWSNPARFDPDRWDTAEVKNRHKTAYIPFAAGPRMCIGFNFALQEVKVFLPKLLYRYKFTKENDGAVEYDPMFQLIRPTNLYVRAERRVKWPPKTEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>W6QEZ6</accession>
    <name>W6QEZ6_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S04</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S04g000189</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QEZ6"/>
    <dbReference type="OrthoDB" id="10376037at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM35308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="49" mass="5184" checksum="20015A71866F8942" modified="2014-04-16" version="1">MAIRIEQGPESTVAELVRLAEEKGGRVMADVATNLISIVMVCAVTLQGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2024-10-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>W6QF92</accession>
    <name>W6QF92_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S04</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S04g000324</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QF92"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM35443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="35" mass="4033" checksum="4171DDB7693897EB" modified="2014-04-16" version="1">MNEEVEGRCDSFPLAITRAVPRTAKGETFRYPPRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W6QGX3</accession>
    <name>W6QGX3_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">homoisocitrate dehydrogenase</fullName>
            <ecNumber evidence="12">1.1.1.87</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LYS12</name>
        <name evidence="14" type="ORF">PROQFM164_S03g000163</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(2R,3S)-homoisocitrate + NAD(+) = 2-oxoadipate + CO2 + NADH</text>
            <dbReference type="Rhea" id="RHEA:11900"/>
            <dbReference type="ChEBI" id="CHEBI:15404"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57499"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.87"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="11">Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-alpha-aminoadipate from 2-oxoglutarate: step 4/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.87" evidence="12"/>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QGX3"/>
    <dbReference type="STRING" id="1365484.W6QGX3"/>
    <dbReference type="OMA" id="DSFVMGE"/>
    <dbReference type="OrthoDB" id="10261637at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047046">
        <property type="term" value="F:homoisocitrate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004449">
        <property type="term" value="F:isocitrate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006102">
        <property type="term" value="P:isocitrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009085">
        <property type="term" value="P:lysine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.718.10:FF:000012">
        <property type="entry name" value="Homoisocitrate dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835">
        <property type="entry name" value="DECARBOXYLATING DEHYDROGENASES-ISOCITRATE, ISOPROPYLMALATE, TARTRATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835:SF48">
        <property type="entry name" value="HOMOISOCITRATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="13">
        <location>
            <begin position="8"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00052540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00060720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00066666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDM33439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="350" mass="37488" checksum="F02C3CB6E85A5661" modified="2014-04-16" version="1">MAAARTLRIGLIPGDGIGREVIPAGRRILESLPASLNLKFSFVDLDAGYETFQKTGTALPDKTVDTLKKECDGALFGAVSSPSTKVAGYSSPIVALRKKLDLYANVRPVKTTAGNSNGKPIDLVIVRENTEDLYVKEERTIDTPNGKVAEAIKRISEHASFRIANIAGEIALRRQSIRAAAATSTRAQPMVTITHKSNVLSQTDGLFRETARRALAAEKFSSIFVEEQIVDSMVYKLFRQPEFYDVIVAPNLYGDILSDGAAALVGSLGLVPSANPCHGSAPDIEGKGISNPIATIRSVALMLEFLGEEKAAAQIYAAVDGNLDAAQFLTPDMGGKATTQQVLEDVLKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W6QHM9</accession>
    <name>W6QHM9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Phosphatidic acid phosphatase type 2/haloperoxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PROQFM164_S03g000428</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PA-phosphatase related phosphoesterase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QHM9"/>
    <dbReference type="STRING" id="1365484.W6QHM9"/>
    <dbReference type="OMA" id="NEPWKKG"/>
    <dbReference type="OrthoDB" id="8907274at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008195">
        <property type="term" value="F:phosphatidate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046839">
        <property type="term" value="P:phospholipid dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03390">
        <property type="entry name" value="PAP2_containing_1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043216">
        <property type="entry name" value="PAP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165">
        <property type="entry name" value="LIPID PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165:SF158">
        <property type="entry name" value="PAP2 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_4G08970)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="119"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="8">
        <location>
            <begin position="124"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="291"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="316"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="336"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM33704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="435" mass="48315" checksum="04772EB0676DB017" modified="2014-04-16" version="1">MEIPAKLPFSKRRLRPRVVISYIFDYVIIIACVAGFAILNTIEPFHQHFSLTNISIQYPYAVHERIPMPYALCISGAFPLVLIILYTLFIDGLFSHHKPHDAASGKRKLRGPHRWKDRLWELNCGILGLLLAQGLAFVITQALKNACGKPRPDLIDRCQPRAGSKDLFPGLSNSTICTGDPALLTDGFRSWPSGHSSSSFAGLVYISLWLGGKLHVMDNRGEAWKSLVIMAPLLAATLVAVSRIMDARHHPFDVITGSMLGIVCGFVAYRQYFPPLTEPWRKGRAYPIRTWGTEPSGPETVRLKGFRQDSSTALRNPEEERMDPPDIPRSEHARPDTSTYIHASNPYPSNVYNRRPHDLDLDGGAWSSSEDDLSSGYEMRHGHTMGQNPGPDHNAHQYDPSNAYVSQTQPLTANAGIHVPDAMAGPGRPLTNIPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W6QHV8</accession>
    <name>W6QHV8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Homeodomain-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S04g000477</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QHV8"/>
    <dbReference type="STRING" id="1365484.W6QHV8"/>
    <dbReference type="OMA" id="YDRVGWF"/>
    <dbReference type="OrthoDB" id="5598695at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070210">
        <property type="term" value="C:Rpd3L-Expanded complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000087">
        <property type="entry name" value="Transcriptional adapter 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007526">
        <property type="entry name" value="SWIRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12374:SF21">
        <property type="entry name" value="SWIRM DOMAIN-CONTAINING PROTEIN FUN19-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12374">
        <property type="entry name" value="TRANSCRIPTIONAL ADAPTOR 2 ADA2 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04433">
        <property type="entry name" value="SWIRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50934">
        <property type="entry name" value="SWIRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SWIRM" evidence="2">
        <location>
            <begin position="287"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="222"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM35596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="385" mass="43432" checksum="8B063B9418410087" modified="2014-04-16" version="1">MTSSAGWKPADQPTTMHRLPSVSSLMSPPETKPLESFPVSLSPFAKPRDSSTRDIQLPPISDDRKRTQSEMDLPSPPVTPYTGNKKSNPNASDQIERDLGSPRDPVLFPPQDSGTDVATDEPLFGPVHPPSAEALVEEHMNSHMAIFRNKLNKPTRDEYLLALSCVPIVSTQYNRNPGAWAREERETLERQMAMMNRYRSGDYEPKLKKIAPAPVKRLGTQPRVQRTRVKRTPKSTPKQQVFDNFEPPQTPLTKPRTLGTNRDDTDYHSLKDYSPPAETLGSNAKALKADWKGQMLDLSNDPDRNILSPAELNLASTLRLSCATYLCSKRRIFEARVRALGVGKEFRKTDAQQACKIDVNKASKLWTAYERVGWFRAEYFHKYLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W6QI60</accession>
    <name>W6QI60_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S04</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S04g001001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM36120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QI60"/>
    <dbReference type="STRING" id="1365484.W6QI60"/>
    <dbReference type="OMA" id="WDNYAGQ"/>
    <dbReference type="OrthoDB" id="5364946at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40625:SF2">
        <property type="entry name" value="GTP-BINDING PROTEIN ESDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40625">
        <property type="entry name" value="GTP-BINDING PROTEIN ESDC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="164"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM36120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="260" mass="28829" checksum="DE4F198BFC7721CA" modified="2014-04-16" version="1">MAAVQLKFSLRTSSNVKTVHLVGSWDNYQRQIPLSSEGKPGAWVGKFRFQTSMLQLGGRYWYYYMMDGYHVSHDPAVEYTVEPTTGRKLNILDVPGGKPTSRSSAPKTSRADVVTGRALSPSRIQHPKPTKNYASRQLREADFPPTVDELTRRFAGSRLSDEYSYSNSPPSSAGSSVSSRSSSGSTSPSSLSSMSDPPVHCRCQRYGITRKGDRVKLDCGGTRCGYQSSDDSCSESDCESDEEYRRARNAVRRQGIVVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W6QI69</accession>
    <name>W6QI69_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S05g000346</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QI69"/>
    <dbReference type="OrthoDB" id="10487935at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM36513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="66" mass="7623" checksum="E62D5A950FECD5D5" modified="2014-04-16" version="1">MELTEARINPMKTSDEIWRSIGILNPTHGDKSLSWYVTNCGSGAELDRRRHVTSVTARRRPKDYFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W6QIA9</accession>
    <name>W6QIA9_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glutaminase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S03g000648</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QIA9"/>
    <dbReference type="STRING" id="1365484.W6QIA9"/>
    <dbReference type="OMA" id="WTGYLVR"/>
    <dbReference type="OrthoDB" id="431715at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052743">
        <property type="entry name" value="Glutaminase_GtaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032514">
        <property type="entry name" value="GtaA_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033433">
        <property type="entry name" value="GtaA_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31987">
        <property type="entry name" value="GLUTAMINASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31987:SF12">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_3G10910)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17168">
        <property type="entry name" value="DUF5127"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16335">
        <property type="entry name" value="GtaA_6_Hairpin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004879845" description="Glutaminase" evidence="1">
        <location>
            <begin position="20"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="domain" description="Glutaminase A N-terminal" evidence="3">
        <location>
            <begin position="118"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="Glutaminase A central" evidence="2">
        <location>
            <begin position="351"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="Glutaminase A central" evidence="2">
        <location>
            <begin position="530"/>
            <end position="759"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM33924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="811" mass="90488" checksum="6A2D8058417BEE85" modified="2014-04-16" version="1">MQLSLVVLAAVFQASVSTASTLTPPVIPLIVRNPYLSTWLANARDAPWLKWPMFYTGEEVGLSLMAHVPSQNTVYPLLGKPHESLDNKSGYKTKFPNYLGLNYDASTTNLTYHIDTGTGNPLDVTISFLSPITPTSTLRQSIPASYVTIDVQGDVDVSIYMDVDGRWVSGDTGSKIKWEWDSLKTEYEDLTLNQWQVQRENELLLTEIRDRAEWGTLHFTGPSSAKFQSGDAIDVRRVFASSGTLRNTNDDKFRAIQDRAPVFAFSKSFHLGHSSKIYNDSVTFTLAFIQIPVVQYASSRGLTMMRPLWESWYPTTEELLDFHYRDYAAASSLASNYSQQVADDAYLSGADDYVDIVALSARQVMGATTFSGTPDDPILFLKEISSNGNFQTIDVIFPAFPFFLYTNPRWLAYLLEPLIEHMLSGQYPNKYAMHDLGTHFPNATGHPDGKDEYMPVEECGNILIMGLAIVNSLRYEDPTAASSIWSTQGLPSSSSEGETSGLFPLGNLQVLSGIAHQDSKWGGGSKGQHQAEKWVKRSYSLWKQWTGYLVEFSLEPANQLSTDDFAGWLALQTNLALKGIVGINAMSKIAEVAGHDADAAHFKKVARDYITKWEKFGMSRDGSHAKLAYDWYGSWTTIYNLYADAQLCFHLEGTDTDSPGFVPRHIYQKQSVWYHYVRQKYGLPLDSRHMYTKTDWEFFSMAVASKAVRTEILDSVARWVNETTTDRPLTDLHNTEGDGGFPGPNFFARPVIGGHFAFLALERACGGKAMPGLSFLDEVDEETLAVWAQSAESAAKEFDMSGQNRHGEGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W6QIN9</accession>
    <name>W6QIN9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major facilitator superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PROQFM164_S05g000521</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. TCR/Tet family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QIN9"/>
    <dbReference type="OMA" id="SEWITYP"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000196">
        <property type="entry name" value="MFS toxin efflux pump (AflT)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF199">
        <property type="entry name" value="MFS EFFLUX TRANSPORTER INPD-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01036">
        <property type="entry name" value="TCRTETB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="141"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="175"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="208"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="272"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="312"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="348"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="375"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="405"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="511"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="51"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="10"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM36688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="550" mass="58710" checksum="9802D197AFC20ABB" modified="2014-04-16" version="1">MVINTSNDGHPADPEKQSKTSITVDREEYVPEADQSSAAICTSSWIAISLVVFSLALSMFLLGLDSTIVSTAIPEITNRFHALDDVGWYASAYMLTFCAIQLIWGKLYSFWSAKSVYLAALFIFEVGSLLCGVAPSSTAFIVGRAIAGAGSGGVSAGSFVLVAHRVPLRHRASMVGIVSAAFGVGSIAGPLVGGAFTTNTQLTWRWCFYINLPLGLFVALVIFLCIRPIKNAPNADIDQPQLFSQSSMKEKIRQMDLPGWGGTKYAWSSGRIITLLVLGPVLLLAFASIQVFTKVQSHVTVPMRVVQNRNIWGSSMYGSCIVAAFFTLMYYLPIWFQAIKGASPVRSGIMTLPTIISFVIFSTSGGALTSLAGCHAPFACLSVILIATGSGLLSTLEVHTGAGKWIGYQILFGAGSGLGIQTALTTAQALPVADIAIGTAIIMFCQNLMGSIMVSVAQNVFTNELVRYLAEEVDGIDAQAVLSMGATEISDHIPSDQYGTVLKAYNKALTHTFYVAVALSSAAVMGAVCLRWKPAMRSLDETYAPRHRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W6QIR8</accession>
    <name>W6QIR8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sad1/UNC-like, C-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PROQFM164_S01g003299</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QIR8"/>
    <dbReference type="STRING" id="1365484.W6QIR8"/>
    <dbReference type="OMA" id="EFFCPVS"/>
    <dbReference type="OrthoDB" id="266334at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000082">
        <property type="entry name" value="Sad1/UNC domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045120">
        <property type="entry name" value="Suco/Slp1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012919">
        <property type="entry name" value="SUN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12953">
        <property type="entry name" value="MEMBRANE PROTEIN CH1 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12953:SF0">
        <property type="entry name" value="SUN DOMAIN-CONTAINING OSSIFICATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07738">
        <property type="entry name" value="Sad1_UNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51469">
        <property type="entry name" value="SUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004882073" evidence="6">
        <location>
            <begin position="42"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="domain" description="SUN" evidence="7">
        <location>
            <begin position="216"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="99"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="156"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="202"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="445"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="759"/>
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        </location>
    </feature>
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        <location>
            <begin position="493"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="531"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="542"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="558"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="759"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="795"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="814"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="831"/>
            <end position="850"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM29487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="879" mass="95818" checksum="200C4E72C6B5D9F0" modified="2014-04-16" version="1">MRVSDHQIDSMLTTRPSLTFWIYRASIILALCHSALSNATAQPPPNGAQTAHHTTPATCPAKSTWQTESELFHLPPCLETRWGPGRDIYLASAPDTNATANEPVVNPPIIPSGTPGERAKTIADQSAEQDQDTDSLLDGGNFLSFEDWKKQNLAKVGQSAENVGGSRRAAAAGKEDRRQPTGINNALDSLGDDAEIELDFGGFGAETPEASPTAWGSHIPSREAGQSGNADGRGNVDVQGQGALQRDASRRKDAGTTCKERFNYASFDCAATVLKTNPESKGSSSVLIENKDSYMLNECRAQNKFLVLEMCDDILVDTVVLANYEFFSSIFHTFRVSVSDRYPAKPDQWKELGVYEARNTREVQAFAVENSLIWARYLRIEFLTHYGHEFFCPVSLIRVHGTTMMEEYKHGESSDHVEVEELEASEAIQVPEDLEIKPVEMPVEESIPAVEPSQPSLTVEEICPNPPSEAVSPFATHNDGDTCSIDDGPLFPTPSSSATTDQTNPPPKQNSTAAVGGSPSATNVAPPAPSKAEDIRKQGEPAKSVVAAPDASSVSFEPAQQNATSETAGKPTTNPKEEQNSPLPESTRPTNTQPPSANPTTQESFFKSVHKRLQMLESNSTLSLLYIEEQSRILRDAFNKVEKRQLAKTSTFLESLNVTVLNELREFREQYDHVWKSVALEFEHQRIQYHQEVHSLSGQLGVLADELVFQKRVTVIQSIMVLCCFALALFSRGSGSNYMEFPAVQRMVARSYSLRSSSPIFATPSASPGSTRPTSSSYRENGGHRRNLSDSSQDSATSPTAAYSPPTPTSSSSPERDVGETDRVEEPVSPKSMSVPTLGTPQPRSQSTPPVLNGRPDDLDMTTPDDVARVTDTPQSPEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W6QIS9</accession>
    <name>W6QIS9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Zinc finger, C2H2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S01g003309</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QIS9"/>
    <dbReference type="STRING" id="1365484.W6QIS9"/>
    <dbReference type="OMA" id="CMTPQKR"/>
    <dbReference type="OrthoDB" id="18440at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039258">
        <property type="entry name" value="ZNF511"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21354">
        <property type="entry name" value="ZINC FINGER PROTEIN 511"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21354:SF0">
        <property type="entry name" value="ZINC FINGER PROTEIN 511"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="190"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM29497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="241" mass="27436" checksum="CF42D16E8C735ADB" modified="2014-04-16" version="1">MSKRPRSRSRSPSLDQDSISVSSIAVNTTTPPSERNKLIDSDTNLLLPEVMHCSLPPHRETLSFTSYDDYEVHYLQSHVNRCSKCSKNFPTGHLLNIHIEENHDPLAAARRARGDKTYGCFIEDCERKCSTPQKRRLHLIDKHMFPRSYNFYIVNDGIDKQTSMLRPMNSHRRRLSTSSALEGRLRRRSSASQSNPPAAAIPENKPPNDMDMDIDDLEKSMSALKFVPTSVTRNRNKVAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W6QJK5</accession>
    <name>W6QJK5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Glucose-methanol-choline oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PROQFM164_S05g000029</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QJK5"/>
    <dbReference type="STRING" id="1365484.W6QJK5"/>
    <dbReference type="OMA" id="NHFESCA"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.410.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF152">
        <property type="entry name" value="OXIDASE (CODA), PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04090)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0134">Cell wall</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0274">FAD</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="7">
        <location>
            <begin position="265"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM36196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="542" mass="59816" checksum="FD8E5077AFE56B80" modified="2014-04-16" version="1">MATTNELLAADVNSYDYIVVGGGTAGCVIAARLAEYLPNKRTLVIEGGPSDFMDDRVLNLKEWLSLLGGELDYDYGTTEQPMGNSNIRHSRAKVLGGCSSHNTLISFRPFEYDCRQWVSKGCKGWDFETFTRIIDNLRNTIQPVHARHRNQLCKDWIQACSSAMNIPVIENFNDDIRKTGELTEGVGFFNISYNPDDGRRSSASVAYIHPILRGDEKRPNLTILTNAWVNKINIEGDTVTGVDVTLQSGVKHTLRAQKETILCAGAVDTPRLMLLSGLGPREQLSALGIPVVKDIPGVGENLLDHPESIIMWELNSPVDHNMTTMDSDAGIFLRRELPDAAGFDGKIADVMMHCYQIPFTLNTTRLGYDEPLNAFCMTPNIPRPRSRGRIFLTSADPSVKPSLDFRYFTDPEGYDAATIVAGLKAAREIAKQSPFKEWIKREVAPGPKVQTDEELSEYGRRVAHTVYHPAGTTKMGNVLTDPMAVVDPTLKVRGLKGIRIADAGVFPDMPSINPMLTVLAIGERAAELIAGEAGWSRNQPRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W6QJQ9</accession>
    <name>W6QJQ9_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Lysosomal dipeptide transporter MFSD1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="22">Major facilitator superfamily domain-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="26" type="ORF">PROQFM164_S06g000013</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="26" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="23">Lysosomal dipeptide uniporter that selectively exports lysine, arginine or histidine-containing dipeptides with a net positive charge from the lysosome lumen into the cytosol. Could play a role in a specific type of protein O-glycosylation indirectly regulating macrophages migration and tissue invasion. Also essential for liver homeostasis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>L-alanyl-L-lysine(out) = L-alanyl-L-lysine(in)</text>
            <dbReference type="Rhea" id="RHEA:79415"/>
            <dbReference type="ChEBI" id="CHEBI:192470"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-alpha-aminoacyl-L-arginine(out) = L-alpha-aminoacyl-L-arginine(in)</text>
            <dbReference type="Rhea" id="RHEA:79367"/>
            <dbReference type="ChEBI" id="CHEBI:229968"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-alpha-aminoacyl-L-histidine(out) = L-alpha-aminoacyl-L-histidine(in)</text>
            <dbReference type="Rhea" id="RHEA:79375"/>
            <dbReference type="ChEBI" id="CHEBI:229967"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-alpha-aminoacyl-L-lysine(out) = L-alpha-aminoacyl-L-lysine(in)</text>
            <dbReference type="Rhea" id="RHEA:79383"/>
            <dbReference type="ChEBI" id="CHEBI:229966"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-arginyl-L-alpha-amino acid(out) = L-arginyl-L-alpha-amino acid(in)</text>
            <dbReference type="Rhea" id="RHEA:79371"/>
            <dbReference type="ChEBI" id="CHEBI:84315"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-arginyl-glycine(out) = L-arginyl-glycine(in)</text>
            <dbReference type="Rhea" id="RHEA:79391"/>
            <dbReference type="ChEBI" id="CHEBI:229955"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-aspartyl-L-lysine(out) = L-aspartyl-L-lysine(in)</text>
            <dbReference type="Rhea" id="RHEA:79411"/>
            <dbReference type="ChEBI" id="CHEBI:229953"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-histidyl-L-alpha-amino acid(out) = L-histidyl-L-alpha-amino acid(in)</text>
            <dbReference type="Rhea" id="RHEA:79379"/>
            <dbReference type="ChEBI" id="CHEBI:229964"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-histidyl-glycine(out) = L-histidyl-glycine(in)</text>
            <dbReference type="Rhea" id="RHEA:79395"/>
            <dbReference type="ChEBI" id="CHEBI:229957"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-lysyl-L-alanine(out) = L-lysyl-L-alanine(in)</text>
            <dbReference type="Rhea" id="RHEA:79399"/>
            <dbReference type="ChEBI" id="CHEBI:229954"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-lysyl-L-alpha-amino acid(out) = L-lysyl-L-alpha-amino acid(in)</text>
            <dbReference type="Rhea" id="RHEA:79387"/>
            <dbReference type="ChEBI" id="CHEBI:229965"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-lysyl-L-lysine(out) = L-lysyl-L-lysine(in)</text>
            <dbReference type="Rhea" id="RHEA:79403"/>
            <dbReference type="ChEBI" id="CHEBI:229956"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>L-lysyl-glycine(out) = L-lysyl-glycine(in)</text>
            <dbReference type="Rhea" id="RHEA:79407"/>
            <dbReference type="ChEBI" id="CHEBI:191202"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="24">Homodimer. Interacts with lysosomal protein GLMP (via lumenal domain); the interaction starts while both proteins are still in the endoplasmic reticulum and is required for stabilization of MFSD1 in lysosomes but has no direct effect on its targeting to lysosomes or transporter activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Lysosome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG792020">
        <property type="protein sequence ID" value="CDM37053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QJQ9"/>
    <dbReference type="STRING" id="1365484.W6QJQ9"/>
    <dbReference type="OMA" id="FNICASC"/>
    <dbReference type="OrthoDB" id="424834at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052187">
        <property type="entry name" value="MFSD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23512">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23512:SF3">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0458">Lysosome</keyword>
    <keyword evidence="6 25" id="KW-0472">Membrane</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 25" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 25" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="9"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="168"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="219"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="262"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="287"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="319"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="392"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="427"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00044891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00044898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00044899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00044900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00044903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00044912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00044919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00044924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00044985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00045018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00045709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00046376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="CDM37053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="451" mass="48801" checksum="051A4B332DD894D3" modified="2014-04-16" version="1">MGALIDRHWRVLMAVCTLMWGIYFIYDLPAPLSVSLQEHLLLSSSQYTYFVSALYTAYAAPNTILPFFSGFAVQRVGKRTVLLATLTSVIVGQLIFAVATQLRLQSGMMIGRVLIGLGGEIIGVLGSEITTRWFKDKELSLALSMVLCISRLGSVGASVFVPRMVESFGVVCVVWIGSIVPLGVAVTGAFYLLAVDTTTSHHESENIDSIKSLRRFPAIFWQLALICILGYGGINTFTISAQRFLAAWFYDGDQRKAGFATGIPYFLSGILTPVFGLLLNLPWFRSYPGALGATNILMMAAHLLLLYRIGPIGPMCMLGIAFASYGVVFWAGLARCLLSIVESCSSKTNMPEAGCRASDELEYGTIQLPTQLSDDRSDADGDNLPGETGEGIITLGYGIMTSLNSLSTAVVPILLAKIENAVGFTGLQVFFLILSLLGLFASVGLSWSWRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W6QK52</accession>
    <name>W6QK52_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S05g000593</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QK52"/>
    <dbReference type="OMA" id="EPEFEWV"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="202"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="440"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="263"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="92"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="202"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="443"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM36760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="567" mass="69221" checksum="CFDB4435CA39DB19" modified="2014-04-16" version="1">MPVRAMYDDEYSSHDSEFETDVSTRRTGVRTHIRERSVSRQRRPEIITREYITPPIQTRVPRSASISSRHREYELPVAPTAPAVMIFNEQGLKSESRSENKPQSRRVQQRFSDKYNVNRFEDEEEEDIVQVPVAPRRRERAVSNVSRTASPLQRDHELAMNQHMMERNDIRQDIGQQLLERNDLRQDMDLWKHQQEIERLQRELQKSRRAEQERSHEHSRSREQIIVNQPDPHDSRMLREELEYEEEISDRLRKLQHFERKHLSEEEERKAGERYQLKQLAAEKRAAAEQEEVRRKLMEERLKEIACAQDEKIQREKLVREEKWKELARLTEEQEARDKLVREEKWKRLAREKEEEEEREKLIQQIRDEDMRKAREAEEKRKKELAVKAAAVEEWKLEQERRKQREAEEAMQKAREFREHLRSIGYSEEEIDGIINKKKHDEKKKEEKKEKEEDRREERREERRDERKEEKITWIKVHRKHLMPETLIAYGLPWDWDEHDNNYIIIKKWIDDDFQEQLFAHTRRLRETKMLTETSHSMTELKVNDRRKDKMFLVRKKSPSGRVRVFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W6QKD6</accession>
    <name>W6QKD6_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type DNA-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PROQFM164_S05g000299</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QKD6"/>
    <dbReference type="STRING" id="1365484.W6QKD6"/>
    <dbReference type="OMA" id="TIEVRHY"/>
    <dbReference type="OrthoDB" id="5376287at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540">
        <property type="entry name" value="TRANSCRIPTION FACTOR (ACR-2), PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540:SF5">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="8"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDM36466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="209" mass="23460" checksum="C0B1FAFDCC0683C5" modified="2014-04-16" version="1">MRQSLRRSCDACAKSKSSCDLRTPRCSRCVKRQVECAYANEPSTGPATSGWQNGTSTSALDGSGTLTNYRFGSLDPFDSYPQTRLPREHVQRLIYSFLHKIAFQYYPLDLNATSNPFLISWWPLALGDPALFHVSLQTACLDEELLAQKGFQTSELLMADSVALLRRKVEYMSLAVQDGTMNSVITLATIEVRHYSTLVCYCVRIRTNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>W6QKK0</accession>
    <name>W6QKK0_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Translation initiation factor eIF2B subunit beta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">eIF2B GDP-GTP exchange factor subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PROQFM164_S02g000256</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM164</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">Component of the translation initiation factor 2B (eIF2B) complex which is a heterodecamer of two sets of five different subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta and delta comprise a regulatory subcomplex and subunits epsilon and gamma comprise a catalytic subcomplex. Within the complex, the hexameric regulatory complex resides at the center, with the two heterodimeric catalytic subcomplexes bound on opposite sides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the eIF-2B alpha/beta/delta subunits family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QKK0"/>
    <dbReference type="STRING" id="1365484.W6QKK0"/>
    <dbReference type="OMA" id="SHSCAVA"/>
    <dbReference type="OrthoDB" id="269919at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005851">
        <property type="term" value="C:eukaryotic translation initiation factor 2B complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10470:FF:000008">
        <property type="entry name" value="Translation initiation factor 2B, beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10470">
        <property type="entry name" value="Translation initiation factor eif-2b, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051855">
        <property type="entry name" value="eIF2B_beta_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000649">
        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042529">
        <property type="entry name" value="IF_2B-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45859">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45859:SF1">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01008">
        <property type="entry name" value="IF-2B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 11" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="115"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="137"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="171"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDM30107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="434" mass="47366" checksum="CEE872B23D7BD68A" modified="2014-04-16" version="1">MPSSSLALTPGLGSFLKCLKTNPIDTSIETLISLLKRRQIRHSRSCATATAYLLRSVISACRTTDSAKLIERVQSVGRRLMAAQPREMVVGNIVRRVLGLIRDEAEDDRDAEFALSDIGSESQPQTPRAYDDPSLPLDRDSPSFRSDERSSRPPLTSMFSLLSHPEPEHSLPSTPGSSSPNGRLPGHGPSKDVRAEVLEGIGEIIDELGQVDDQIAAYALDHIHSNEIILTHTSSTTVQKFLLKAAAKRKFTVIHAESYPNNHEDTHATVSGSAVTDDDNIGLEAFQKPLIEHGITVILIPDSAVFALMSRVNKVILGTHSVLANGGLVAAAGTRVIARAAKVHQTPVVVVSGVYKLSPVYPFDFDSLIEYGDPSKVLPYEEGDLVDLIDVQNPIYDYVPAELVDLYITNLGGHAPSYLYRIVSDHYRKEDISF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W6QKN0</accession>
    <name>W6QKN0_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aldehyde dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ALDH3H1</name>
        <name evidence="8" type="ORF">PROQFM164_S05g000828</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QKN0"/>
    <dbReference type="STRING" id="1365484.W6QKN0"/>
    <dbReference type="OMA" id="EIDWCKQ"/>
    <dbReference type="OrthoDB" id="440325at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006081">
        <property type="term" value="P:aldehyde metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016117">
        <property type="term" value="P:carotenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07135">
        <property type="entry name" value="ALDH_F14-YMR110C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000025">
        <property type="entry name" value="Aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000004">
        <property type="entry name" value="Aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012394">
        <property type="entry name" value="Aldehyde_DH_NAD(P)"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43570">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43570:SF11">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036492">
        <property type="entry name" value="ALDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0125">Carotenoid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="7">
        <location>
            <begin position="13"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="222"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR036492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR036492-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM36995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="526" mass="57318" checksum="B8C173F2F5952210" modified="2014-04-16" version="1">MVELPEFKTVPLEEIPVRVATARKAFNENKTRDVEFRLVQLRKLYWAVKDNEEAIMEACTQDLNKPRFETNLAESGWLLNDIVFTTRNLHEWAKDEKANDIDLAFKFMNPKIRKDPLGTVLVIGAFNFPFQLTLGPVIGAIAAGNTVVIKPSENAPRSAAVMQKIIEESLDPSCYMVLQGGIPETQALLAERWDKIFFTGGANVGRIIAKAAAPNLTPVVLELGGINPAIVAKSADPRLVARRLLWGKLLNAGQICTSQNYLLVERSLVPAVVQEFKNAYKEFYPNGSKGSSDYARIVNLPAFNRLKTMLDNTKGKIVMGGTMDEKELFIEPTVVLVDSVEDSLCSQESFGPFIPILPVDSLDEGISVANSVQSTPLGLYPFGNKADVERIISSTRSGGVSCNDAALHIPTLPFGGVGESGHGAYRGRASFDVWVHRRTITSSPSWLEGILAIRYPPYAGKISTFNAASALSPDFDRSGKKLGMGLLRCIFTLGGGSAKAGAFRATALAAIAYVVLQILERRSAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W6QLL8</accession>
    <name>W6QLL8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S05g000704</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QLL8"/>
    <dbReference type="STRING" id="1365484.W6QLL8"/>
    <dbReference type="OMA" id="GASEGMW"/>
    <dbReference type="OrthoDB" id="2142759at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057203">
        <property type="entry name" value="DUF7881"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25324">
        <property type="entry name" value="DUF7881"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13391">
        <property type="entry name" value="HNH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7881" evidence="2">
        <location>
            <begin position="9"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="HNH nuclease" evidence="1">
        <location>
            <begin position="116"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM36871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="294" mass="33636" checksum="75D599CE9F47164A" modified="2014-04-16" version="1">MPSRDRSRWRNVHFYNASNDLLGGFYQAGSITDANLIWILRSVLLVQAENLTIKHRASDRIITPSNNSVVPGDYVISCDGTIRVTDEPWFARVISFSESGREDSFRTEVRQRDGRCVISGDINLLEPWDIWDGLQAAHVFPLEKENLWTQYNFGRWITNMDHTTGVSKINSVQNGLLMGATLHGCFYQYMFSINPDIVTFAPDSYRINGKVLDPICRNPNDLNHVADELLRWHFRQSVLANMRGAGEPIFESDFPPGTDQIATLRDEPYGKERLGMEFELRLGPRAKEEEESTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W6QMS9</accession>
    <name>W6QMS9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S02g001062</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QMS9"/>
    <dbReference type="OMA" id="CSAQRNT"/>
    <dbReference type="OrthoDB" id="2121879at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056124">
        <property type="entry name" value="DUF7707"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38118:SF4">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38118">
        <property type="entry name" value="ANCHORED CELL WALL PROTEIN 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24808">
        <property type="entry name" value="DUF7707"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004881774" evidence="1">
        <location>
            <begin position="18"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7707" evidence="2">
        <location>
            <begin position="30"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM30912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="200" mass="20312" checksum="C75C856278E47753" modified="2014-04-16" version="1">MRSSIIFLSALATAVMADNSTDTYTFPAGFNIGLVDSGTLSSWCSAQRNTCPDLCSSGTKLNSCDPTTLKFSCVCSDGSTPNVTSYIQTVPFYVCQATYGQCINSHPNDAEGQRACKQASADCGSKNASAVTTTSSAAATSASATSTLALATTTDSSTTATSSVAAASTTTNAAVALGDLTQYSTGLMAGLMFVAARMIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W6QNE0</accession>
    <name>W6QNE0_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Probable transposable element</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S12g000032</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792026">
        <property type="protein sequence ID" value="CDM38423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QNE0"/>
    <dbReference type="STRING" id="1365484.W6QNE0"/>
    <dbReference type="OrthoDB" id="4307211at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM38423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="75" mass="7870" checksum="AB330C2FD8FFFAAC" modified="2014-04-16" version="1">MILRSRVGDALNSVSSLLGGSTEGERGNPDTVSRAKTVEAVLDFAEASQRFRSRAPQGQPNSGSGNRPGQAVTRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W6QPM6</accession>
    <name>W6QPM6_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S07g000295</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792021">
        <property type="protein sequence ID" value="CDM37946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QPM6"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM37946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="85" mass="9238" checksum="5369E885EBDA57F1" modified="2014-04-16" version="1">MCTRHIAVDTNLGSNHCAQLLLPTLRSLLDFYLLFTVDSPSTLGRDGDKGSRTFRVSLTSDRPQVPKNLLVKPAIAEAGNDIIGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W6QPN5</accession>
    <name>W6QPN5_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Azaphilone pigments biosynthesis cluster protein L N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S08g000007</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792022">
        <property type="protein sequence ID" value="CDM37956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QPN5"/>
    <dbReference type="OrthoDB" id="5068804at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031348">
        <property type="entry name" value="PigL_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17111">
        <property type="entry name" value="PigL_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004881810" description="Azaphilone pigments biosynthesis cluster protein L N-terminal domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="Azaphilone pigments biosynthesis cluster protein L N-terminal" evidence="2">
        <location>
            <begin position="2"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM37956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="77" mass="8712" checksum="B4A802AAFED267D8" modified="2014-04-16" version="1">MVDPLSVTTSILLLAGFALQSFLSPRNVIDDFQTSKKDVRKLKKGLQAVCQVLGWVHRVAAEYQHELKVLNFQLRVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W6QQH6</accession>
    <name>W6QQH6_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PROQFM164_S05g000152</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM164</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QQH6"/>
    <dbReference type="STRING" id="1365484.W6QQH6"/>
    <dbReference type="OMA" id="PWIIHRH"/>
    <dbReference type="OrthoDB" id="3934656at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11060">
        <property type="entry name" value="CYP57A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000050">
        <property type="entry name" value="Cytochrome P450 monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF232">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="479"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDM36319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="531" mass="59888" checksum="0638AF408C75C9C9" modified="2014-04-16" version="1">MAIISEALISVWSHLPAILVTLVIFHFGRKYLNPGLTSIPGPLLARITNLWRFIDVANGRSEVTLHNLHQKHGDYVRLGPNVVSVRNLDALKTIYGINKGYQKTNFYSVQQQLVKGRPTPTLFTTTDEVFHAAIKRPVSSAYSMSTLTEFEPFVDKIIHTLFGRLDEFVAEAKVCDIAAWLQYCKSHSSRDMRAEADAAQKDAFDVIGELTFSKPLGFLEKGNDVDGIIVALEHTLDYVGKIGQMPWLDYLFIKNPLRSFLTGGSTGAVARFARARLDERLKQKSTPVAKTHQDFLDHFLKAKDEHPTIVDDNQVLSYTISNMNAGSDTTAISLRAILYYTLKNPPVSIKLHQELTIALKENRISVPVSWKQSQEQLPYLDAVIKEALRLHPAVGLMLERVVPAEGLQLPDGGPFLPAGTIVGANPWIVHRHRVFGEDVESFVPERWLKMDTESEANFLDRKQKMLRATFTFGAGPRTCIGKNISLLEIYKLIPSLFLRYKIEFNDPSAEWEIVNAWFVRQKNMDVRLSCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W6QQZ1</accession>
    <name>W6QQZ1_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Oxidation resistance protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">oxr1</name>
        <name evidence="8" type="ORF">PROQFM164_S02g002118</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">May be involved in protection from oxidative damage.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the OXR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QQZ1"/>
    <dbReference type="STRING" id="1365484.W6QQZ1"/>
    <dbReference type="OMA" id="MPSVMPW"/>
    <dbReference type="OrthoDB" id="26679at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23354:SF62">
        <property type="entry name" value="MUSTARD, ISOFORM V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23354">
        <property type="entry name" value="NUCLEOLAR PROTEIN 7/ESTROGEN RECEPTOR COACTIVATOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00584">
        <property type="entry name" value="TLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TLDc" evidence="7">
        <location>
            <begin position="111"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="61"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="214"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="284"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="10"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="241"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00037112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00040604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM31967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="381" mass="40831" checksum="D47288ECDC2DA603" modified="2014-04-16" version="1">MSSPSQENIPSDTPTSSTSTPGSPSQAPTEKPPYQSAASYLSYPVSHVVSGIYRRIADPEPTKEMPSVMPWSRSSSSEAFTPHRTASPFQPPPLTPLTLGIPTGADSLQQQLLTRPLAEEIRLLVPPRLQLAETWRLAYSLNRDGASLSTLYENCAEFSHRSPRVGYVLVIRDSSPYSSVFGAYMTDAPHPDSQFFGTGECFLWRASVLPPPASFPLASPGEGPQSEEALERAGLPPPPSADTTTAGRWSTLRNDKSKPARAESPAHNLNMNIKTNLAAASGGVLAPPSPSSIHSPSPSGASTPERIRFKAFPYSGVNDYMIFCETGFLSLGGGDGHYGLWLDSSLEKGVSSPCQTFGNEPLSDEGIKFDVLGVEVWYVGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W6QR11</accession>
    <name>W6QR11_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ankyrin repeat-containing domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S12g000010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792026">
        <property type="protein sequence ID" value="CDM38401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QR11"/>
    <dbReference type="STRING" id="1365484.W6QR11"/>
    <dbReference type="OMA" id="CECAARW"/>
    <dbReference type="OrthoDB" id="5135691at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM38401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="219" mass="25223" checksum="262F02C39D75C403" modified="2014-04-16" version="1">MNSRNEMSLPNPDKIEQISILDCPTETLWIIASTLEGGDISALARTNSILYPKLRLALIEYNIRYQNSSALHWAAKQQLRLCKDLAFLPGRCECAARWFLSLMTAANYGSELVTNILLRKKDLHVNWRNTNGESALWYSVVKESPAVLNQLLQHPSVKIDLPNREGQTVLWWEIDMRGQLFLRTKRYLQSCLLTSQTIRILAAFTHHHDYMTLDYEDSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W6QSJ7</accession>
    <name>W6QSJ7_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein mS41</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PROQFM164_S02g002613</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mS41 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QSJ7"/>
    <dbReference type="STRING" id="1365484.W6QSJ7"/>
    <dbReference type="OMA" id="GMWEDRR"/>
    <dbReference type="OrthoDB" id="18595at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039603">
        <property type="entry name" value="Ribosomal_mS41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019083">
        <property type="entry name" value="SAM_Ribosomal_mS41"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28235">
        <property type="entry name" value="PROTEIN FYV4, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28235:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09597">
        <property type="entry name" value="SAM_Ribosomal_mS41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01238">
        <property type="entry name" value="IGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Small ribosomal subunit protein mS41 SAM" evidence="6">
        <location>
            <begin position="50"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="218"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="218"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM32462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="247" mass="27585" checksum="DEF92E94740F4515" modified="2014-04-16" version="1">MSVMAMRNSPLGSLTARLFKPVSISNQYIRSLHKNAPPPVPSPTPFVPDVQTFLTLIGREMSKQASKIPSWEELFTLNSNQLRQAGIEPARQRRYLIRKREKFRNGLYGPGGDLETVVDGVAQLRVVEVPINARGLTHEGAQTAVQTSSATLSPGMVKAIVNLAPDVTTYYYGKKNLIKKFAHMKIHRGCQPMGPFLQPLKGSNGTAATISVQEGMWEDKRGHKVDGGERRRREVRNKKRLDERKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W6QSN3</accession>
    <name>W6QSN3_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase</fullName>
            <ecNumber evidence="1">3.1.3.67</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PROQFM164_S06g000074</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM164</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.3.67" evidence="1"/>
    <dbReference type="EMBL" id="HG792020">
        <property type="protein sequence ID" value="CDM37114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QSN3"/>
    <dbReference type="STRING" id="1365484.W6QSN3"/>
    <dbReference type="OMA" id="YPKRAYR"/>
    <dbReference type="OrthoDB" id="16692at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042995">
        <property type="term" value="C:cell projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016314">
        <property type="term" value="F:phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043491">
        <property type="term" value="P:phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051896">
        <property type="term" value="P:regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14497">
        <property type="entry name" value="PTP_PTEN-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051281">
        <property type="entry name" value="Dual-spec_lipid-protein_phosph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029023">
        <property type="entry name" value="Tensin_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12305">
        <property type="entry name" value="PHOSPHATASE WITH HOMOLOGY TO TENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12305:SF81">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51181">
        <property type="entry name" value="PPASE_TENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphatase tensin-type" evidence="5">
        <location>
            <begin position="12"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="4">
        <location>
            <begin position="109"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="248"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="400"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="259"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="278"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="403"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="422"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="447"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="464"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="501"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDM37114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="531" mass="58656" checksum="87EAD7316F64DD39" modified="2014-04-16" version="1">MSSILRQIVAGPRQHHPEAGLDLCYVTDNVIATSGPSSTYPKRAYRNPLDALVNFLDTKHGKEWCIWEFRAEGTGYPDSEVYGRIHHFPWPDHHPPPFAYVPVIMGSMRNWLQRLDEGKESPDTDKNERVAVVHCKAGKGRSGTIACAYLISQEGWKKEDALQRFTDRRMRVGFGSGVSIPSQLRYVGYVDKWANELGKQYVERPVEILEVHIWGLKDGVKVAVEGYVDGGKKIKCFHLFHRNERTVVEDGGSTSEEQEATKPDPNSDSRIKNPIPSPATSSPTVSGSDISGLSSQDHSISAILYKPHKPLIVPSSDVNIDFERRSKASYTGFAMVTSIAHVWFNPYFEGGAEHDSGVFETEWEAMDGIKGSARKGIRALDKLKVVWRYPATETVEASAAIKSEGKGKKTEDSAPVAISEPKPGDSIHEREPADWRGMPHGDKKENQPPSETSSQKSTATSISDKTKKLGHTLEKELGLRKQTGDSQDVSLAGSDDEMTTDEGRKAKIKSVHSEELEGVKTNFEKNGAATG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W6QSU9</accession>
    <name>W6QSU9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Actin cortical patch SUR7/pH-response regulator PalI</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S02g002723</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QSU9"/>
    <dbReference type="OMA" id="DPFNVNT"/>
    <dbReference type="OrthoDB" id="4480814at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051285">
        <property type="term" value="C:cell cortex of cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009571">
        <property type="entry name" value="SUR7/Rim9-like_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052413">
        <property type="entry name" value="SUR7_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28019">
        <property type="entry name" value="CELL MEMBRANE PROTEIN YLR413W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28019:SF2">
        <property type="entry name" value="CELL MEMBRANE PROTEIN YLR413W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06687">
        <property type="entry name" value="SUR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="195"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM32572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="264" mass="28990" checksum="701ACCDAC279DFCF" modified="2014-04-16" version="1">MPSYSAIKLSTKSRLDSLVSTIALSFTVAILVYLSLIFIGYSSSSSPKGLHFLKVDLKEFLKLRDLQIRDPFNVNTALIENKGRNAVEGMASSIHTSANEAIHEATSAASSIDSSEIVYSDPSTSFTFDLSAVLDSTSINLSNILPDINLSLVSGYRRFSQSVVYLYIAGFMVTTLSGVLAYRKVFFSKGSRSLTIFYTLSSILITTATIAVTVIYRVFASKVKNTLQPYSVEVTLRAKMFTTVWLADFFSISGSTIWLEDNAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W6QT26</accession>
    <name>W6QT26_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Bifunctional polymyxin resistance protein, ArnA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S06g000200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792020">
        <property type="protein sequence ID" value="CDM37239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QT26"/>
    <dbReference type="STRING" id="1365484.W6QT26"/>
    <dbReference type="OMA" id="ATPSPIW"/>
    <dbReference type="OrthoDB" id="2130169at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051783">
        <property type="entry name" value="NAD(P)-dependent_oxidoreduct"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079:SF8">
        <property type="entry name" value="NAD(P)-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079">
        <property type="entry name" value="PROTEIN YEEZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM37239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="334" mass="35982" checksum="0992469DB2837C8B" modified="2014-04-16" version="1">MTQIFLTGATGYIGGEVLHALQHAHPDYEVAALIRDEEKAGKVLAAFPKVRVVLADLDNVEIIEKESRKADIVIHAASNKHLESVKAIANGLAGRQNAYYIQVTGASVLSGPEVDSNSYGEPSDQIVDDLDNAADLRDIIRAYKDRRVVDNYILDLGSGGPKTAILFPPIIFGTGNGPVNQRSIQVPSLARAALLQHVGLYLGRGLSRWGIVHIADLADLFVKLVEHAVNATPSPIWNGNGLFFVENGFESFKDVALVIAKEAHSLGYIDSPDSVQSMNLDEANVVIPNGAVFLGTNGQGRASRARKLLGWQPDGESFQSATRETIITEAAQLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>W6QTL8</accession>
    <name>W6QTL8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Elongation factor 1-gamma 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">CAM1</name>
        <name evidence="8" type="ORF">PROQFM164_S06g000461</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG792020">
        <property type="protein sequence ID" value="CDM37499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QTL8"/>
    <dbReference type="STRING" id="1365484.W6QTL8"/>
    <dbReference type="OMA" id="TQYFSWT"/>
    <dbReference type="OrthoDB" id="249703at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03181">
        <property type="entry name" value="GST_C_EF1Bgamma_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03044">
        <property type="entry name" value="GST_N_EF1Bgamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.10:FF:000006">
        <property type="entry name" value="Elongation factor 1 gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000142">
        <property type="entry name" value="Elongation factor 1 gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1010:FF:000001">
        <property type="entry name" value="Elongation factor 1-gamma 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1010">
        <property type="entry name" value="Translation elongation factor EF1B, gamma chain, conserved domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050802">
        <property type="entry name" value="EF-GSTs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001662">
        <property type="entry name" value="EF1B_G_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036433">
        <property type="entry name" value="EF1B_G_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43986">
        <property type="entry name" value="ELONGATION FACTOR 1-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43986:SF1">
        <property type="entry name" value="ELONGATION FACTOR 1-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00647">
        <property type="entry name" value="EF1G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01183">
        <property type="entry name" value="EF1G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89942">
        <property type="entry name" value="eEF1-gamma domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50040">
        <property type="entry name" value="EF1G_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4 8" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="6">
        <location>
            <begin position="2"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="7">
        <location>
            <begin position="91"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="EF-1-gamma C-terminal" evidence="5">
        <location>
            <begin position="248"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM37499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="409" mass="45793" checksum="7953C0E18EB8D634" modified="2014-04-16" version="1">MAFGKLYGLPDNGRTISILVAAKHNDLDLELVNTQANSTAEFNTSAEYLKINPTGKIPAFEGANGFTLSEAIAIAVYVTSQNEKTTLLGKTKQDYASILRWLSFVNSEVLPKFGAWYRPLLGLDGYNKKTVDEASKVALKAISAFETHLTANTYLVGERITLADIFAASLLTRAFATVLDKTWREANPATTRWYNTIINQDAFKAVVPSPKFAEEVVKYVAPKKEPKPKAAAPAAAAPVEASTAEPKAKHPLEALGKPTLILDDWKRKFSNEDPRTVAMPWFWEHFNADEYSLWKVNYRYNNELKLTFMANNLIGGFQTRLEASRKYLFGAQSVYGENYNCVVYGAYMTRGQEWEPAFTVGPDYEGYEFTKLDPSNEADRKLVEDMWSQDVPVTVDGQVKEWADGHVFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W6QUU1</accession>
    <name>W6QUU1_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Unnamed protein product [Penicillium chrysogenum]</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S07g000243</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792021">
        <property type="protein sequence ID" value="CDM37894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QUU1"/>
    <dbReference type="STRING" id="1365484.W6QUU1"/>
    <dbReference type="OMA" id="KIPWRYA"/>
    <dbReference type="OrthoDB" id="7042322at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050478">
        <property type="entry name" value="Ethylene_sulfur-biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43795:SF39">
        <property type="entry name" value="AMINOTRANSFERASE CLASS I_CLASSII DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43795">
        <property type="entry name" value="BIFUNCTIONAL ASPARTATE AMINOTRANSFERASE AND GLUTAMATE/ASPARTATE-PREPHENATE AMINOTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00753">
        <property type="entry name" value="ACCSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="2">
        <location>
            <begin position="85"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM37894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="419" mass="46413" checksum="91990D6C3AE8A47F" modified="2014-04-16" version="1">MMLSFRGSENARELAKPWRFSLTQTYDPMENPTGLISFGLAENRPMRAEIARYINQNVVFTQDSISYRPSAPTAARLPAAAAVHLNNILKPHAPIDPEDILVADCPTSLGSMLGHSLAESGDGILVSRPIYGRFELDYGVESGVKMVYADTTVEEAFSPACVEKYELAFKESSKNIRAVLLVNPHNPVGRCYPVETLKAITRFCNKHNLHLISDEVYASCVFNSGDPEAVPFTSILSLDLAGLIDPNLVHVLYGFSKDFASGGLHLGFLVTKNRQLRQACRTILRLHGASQAAVTIGTVILEDQAFVASFTAKARQSLASAYRFTTSVLNREGINYVKGGNAGFFVYIDLSPYLPRDDYLTPRNREFSLAERLVDAGVFLHPGEEHSRDIGWFRLVFSQEEEILQEGFNRLLSVLRSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W6QUY4</accession>
    <name>W6QUY4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NmrA-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S03g000081</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QUY4"/>
    <dbReference type="STRING" id="1365484.W6QUY4"/>
    <dbReference type="OMA" id="AHEKPHQ"/>
    <dbReference type="OrthoDB" id="419598at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051609">
        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706:SF11">
        <property type="entry name" value="ISOFLAVONE REDUCTASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_1G12510)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="5"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM33357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="318" mass="34390" checksum="F8FC9B8690A18A74" modified="2014-04-16" version="1">MSLAKNILLFGATGNIGSFILDAILTERSQFGRVAIFTSPHTAETKASQLNKLKEQGVEVIVGNVEDENAVKAAYEGIDTVISALGRNALAQQIPLIRLAAASSTVKWFLPSEYGTDIKYGPASANEKPHQLKLKVRAYLEDESSRDDLAYSYVVTGPFAEMYLNLVPGLETAGGWDVKGRRAVLLGEKGKGEVSLTTMKDVGTLVLNTLLHATAETRNAALCVNSFTTSPDQIQAEFERQLDGQPWDVSRTSLAKLREAEAAAWEAGNPAATLLTLRRIWGEGGTLYAQRANGLIGEPKVMSLKDVVANEIQRVSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W6QV67</accession>
    <name>W6QV67_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Aromatic-ring hydroxylase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PROQFM164_S08g000080</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792022">
        <property type="protein sequence ID" value="CDM38029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QV67"/>
    <dbReference type="STRING" id="1365484.W6QV67"/>
    <dbReference type="OMA" id="QSCLHAN"/>
    <dbReference type="OrthoDB" id="1047367at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF172">
        <property type="entry name" value="HYDROXYLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12410)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="8"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM38029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="416" mass="45566" checksum="32D13A5991F1520D" modified="2014-04-16" version="1">MPGWRSLNVGVIGGGIGGMSVAVALRRAGHTVTIYEKSDFAGEVGASVSCAANGTRWLHEWNVDIAKGDPVVLKKLINRDWNTGEPVSVYDLDDYEKRWGYVYNMFHRQYMHAMLKDSALGEGEGAPATLKVNYRCSDIDLKTSTVVFENGEVVSHDLIVGADGIGSAVRGIIGITPEKRASDQSCLHTNVKTEDAIRLGLVNYAEDSALEYWGGQEGKWDKIVLSPCNGGELLSYYCFFPREQGDYSTQAWGAEDRPVEELLAPYPELDRQVFDHLKIGTEIKPWRLWVHDPYPYLQRGSTCLLGDAAHPMMPHQSQGACMAIEDAAALGILFVQAAAAKAAYNINERIGFSVNKDIPTYKVEDAKKVLTIEEMNADIEEKLAAKRGTTYTDKFLCGLPIGLELPNGITIGAVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W6QX43</accession>
    <name>W6QX43_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S03g000831</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QX43"/>
    <dbReference type="STRING" id="1365484.W6QX43"/>
    <dbReference type="OMA" id="INPECCT"/>
    <dbReference type="OrthoDB" id="5135119at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042578">
        <property type="term" value="F:phosphoric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009395">
        <property type="term" value="P:phospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007312">
        <property type="entry name" value="Phosphoesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31956:SF1">
        <property type="entry name" value="NON-SPECIFIC PHOSPHOLIPASE C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31956">
        <property type="entry name" value="NON-SPECIFIC PHOSPHOLIPASE C4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04185">
        <property type="entry name" value="Phosphoesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004880547" evidence="2">
        <location>
            <begin position="20"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM34107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="473" mass="53796" checksum="9A2AA608A031D144" modified="2014-04-16" version="1">MIFYWGFIILMALASLTSTHPTGNTQVWGQLRENIKHVIYLTLENHSFDNIAGYWDFHPEIDNLRNLTFCNDYTNPNWTVYGEPLAICAEPDATEVPLKDPDHNFGGVTYEIFRQWNPTKQDVPKMAGFIERQSEKYNATPGDSAFVIKALNRKKTATLVELASNFAFFDSYFAEHPGPTNPNRQFATSGSSCGFVDNTDQSAGFWNNVTGTTCAVSIFESLSKKNISWKNYYETDIVDGFMYKWVQDNAMDRLVHATELYHDLEAGTLPEFSYLNPECCTVDSMHPTSSMAAGEQMVKHLYDALRRSKYWDNAVLIINFDEHGGFADHVPTPVNVPQPEDGIIFNGTSSNHNFTYDFTRLGVRVPAFIISPWVPANLLIHDQGTMYADDSAYTHSSILHFLQELWGLEGLNNRVQWAKTFETAFTNKRRDDTPKTLVKPTWYGGSGQPEPEPFFFLNQDESYYARRKAQAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W6QYU7</accession>
    <name>W6QYU7_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S03</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S03g001447</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QYU7"/>
    <dbReference type="OMA" id="DVFRGCR"/>
    <dbReference type="OrthoDB" id="4158189at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM34722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="171" mass="18658" checksum="45B00035C75FA2FF" modified="2014-04-16" version="1">MCGDTNRPTFGGTIAVLFPRGTHQSSNTSDRSLSSSPESVSSFASSSSIASMSSYSLFFRDTDATTPKTRAIFRTQDAETYHALKECRNVDMRIEKFGDLSITSQSISPLHQFRLNMGQDKNCNTANSMEIEFELPERLDLGVSDKGVIGRQVTVREQGGSILGIGVVGYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W6QZJ3</accession>
    <name>W6QZJ3_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Genomic scaffold, ProqFM164S03</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S03g001709</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QZJ3"/>
    <dbReference type="STRING" id="1365484.W6QZJ3"/>
    <dbReference type="OMA" id="AGENCWA"/>
    <dbReference type="OrthoDB" id="3800761at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13391">
        <property type="entry name" value="HNH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HNH nuclease" evidence="2">
        <location>
            <begin position="67"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="259"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="28"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="266"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM34982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="373" mass="41322" checksum="92D45A591A250BF3" modified="2014-04-16" version="1">MPRPPSPVRDRQRREPRSPKTPQTPTRAISLPASESSRSASQAWSHSSGVLSVATKLELIRISGKNCWACTTADPQACHVLGKRDTQDNLWAHLGLINYSLRSLSNAILLCASCHGQFDRDNDPGFLLVPTDLDFFIEFEKADRIRRQAGRWPPGRQMPTSGMYKEYLESSGKGDAGYTPMFLKHYLLAGSGVTPEMLRLTAPKYWQGAPAAALRRCIMALGSGRIVALGHQVTQLETLRNLYFSPIEGASAINVHSCDLEPQLDPPQFQDQPAQNPDLEEPKSEPDSEDQDSDPESDHDTYGPHSKEPDFNPNRQHDNRKRQGKGRNQQGSRKQAKHAPGATRHATGENWALGPSATTQDAILRYSPIFARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W6R6E7</accession>
    <name>W6R6E7_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S06g000348</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792020">
        <property type="protein sequence ID" value="CDM37387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6R6E7"/>
    <dbReference type="OrthoDB" id="10364205at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM37387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="106" mass="10990" checksum="FFE089F422562637" modified="2014-04-16" version="1">MQGNIAQSESAKADAMLPTYTPTWVDSTSGNVEAMSGRYGLIEFNAVCSASAIIASTAICLFGSGDAFGGGIAISLWVSCEPSPEDSDWPELGRPRDLGGGVSKVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2024-10-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>W6R7P3</accession>
    <name>W6R7P3_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S07g000210</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792021">
        <property type="protein sequence ID" value="CDM37862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6R7P3"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM37862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="71" mass="8136" checksum="2C27E31B7DCFD842" modified="2014-04-16" version="1">MHKIACTSIPASTLPINHVSYPLAEEYQDYVKSSKYTLYFDLRFSTQSRTRNATAWWSRYPSVAASIKPCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W6PQJ6</accession>
    <name>W6PQJ6_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosomal protein L15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rpl15</name>
        <name evidence="6" type="ORF">PROQFM164_S01g000272</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL15 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PQJ6"/>
    <dbReference type="STRING" id="1365484.W6PQJ6"/>
    <dbReference type="OMA" id="YIRDAWK"/>
    <dbReference type="OrthoDB" id="10255148at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1120.10:FF:000001">
        <property type="entry name" value="Ribosomal protein L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1120.10">
        <property type="entry name" value="Ribosomal protein l15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024794">
        <property type="entry name" value="Rbsml_eL15_core_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000439">
        <property type="entry name" value="Ribosomal_eL15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020925">
        <property type="entry name" value="Ribosomal_eL15_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_uL23/eL15/eS24_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003269">
        <property type="entry name" value="PRK04243.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11847:SF4">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11847">
        <property type="entry name" value="RIBOSOMAL PROTEIN L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00827">
        <property type="entry name" value="Ribosomal_L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01384">
        <property type="entry name" value="Ribosomal_L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="Ribosomal proteins S24e, L23 and L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01194">
        <property type="entry name" value="RIBOSOMAL_L15E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="161"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="169"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="193"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDM26463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="203" mass="24114" checksum="63A97889CFDF1A77" modified="2014-04-16" version="1">MGALKYVEEIQKKKQSDVIRFLLRVRCWELRQLNAIHRASRPSRPDKARRLGYKAKQGYVIYRARVRRGGRKRPVSKGATYGKPTNHGVNQLKYQRALKSTAEERVGRRAANLRVLNSYWINQDSTYKYYEVILVDPQHKAIRRDARINWICNPVHKHRESRGLTATGKKSRGINKGHRYNNTKAGRRHTWKRQNTQSYWRYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>W6PRC4</accession>
    <name>W6PRC4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Phytochrome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PROQFM164_S01g000090</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1365484.W6PRC4"/>
    <dbReference type="OMA" id="WVMKPIN"/>
    <dbReference type="OrthoDB" id="2015534at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009881">
        <property type="term" value="F:photoreceptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009584">
        <property type="term" value="P:detection of visible light"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.130:FF:000048">
        <property type="entry name" value="Sensor histidine kinase/response regulator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.270:FF:000002">
        <property type="entry name" value="Sensor histidine kinase/response regulator, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013654">
        <property type="entry name" value="PAS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016132">
        <property type="entry name" value="Phyto_chromo_attachment"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001294">
        <property type="entry name" value="Phytochrome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013515">
        <property type="entry name" value="Phytochrome_cen-reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043150">
        <property type="entry name" value="Phytochrome_PHY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43065:SF10">
        <property type="entry name" value="PEROXIDE STRESS-ACTIVATED HISTIDINE KINASE MAK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43065">
        <property type="entry name" value="SENSOR HISTIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08446">
        <property type="entry name" value="PAS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00360">
        <property type="entry name" value="PHY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01033">
        <property type="entry name" value="PHYTOCHROME"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50046">
        <property type="entry name" value="PHYTOCHROME_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0157">Chromophore</keyword>
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    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 11" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="1" id="KW-0600">Photoreceptor protein</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
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    <keyword evidence="3" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="Phytochrome chromophore attachment site" evidence="13">
        <location>
            <begin position="427"/>
            <end position="589"/>
        </location>
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        <location>
            <begin position="803"/>
            <end position="1039"/>
        </location>
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        <location>
            <begin position="1270"/>
            <end position="1401"/>
        </location>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
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            <begin position="115"/>
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        </location>
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            <begin position="169"/>
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        </location>
    </feature>
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        <location>
            <begin position="1074"/>
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        </location>
    </feature>
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            <begin position="1136"/>
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        </location>
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        <location>
            <begin position="1234"/>
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        </location>
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            <begin position="1"/>
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        </location>
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            <begin position="46"/>
            <end position="56"/>
        </location>
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        </location>
    </feature>
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        <location>
            <begin position="117"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="174"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1076"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1088"/>
            <end position="1103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1136"/>
            <end position="1146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1161"/>
            <end position="1175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1238"/>
            <end position="1269"/>
        </location>
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    <feature type="modified residue" description="4-aspartylphosphate" evidence="11">
        <location>
            <position position="1321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022543"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
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    </evidence>
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        <source>
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        </source>
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        <source>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CDM26281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="1426" mass="157585" checksum="DD8B63225AAAECC5" modified="2014-04-16" version="1">MTSPHPKDIGMSSPRERSQSVASLKPIELSETEQRQTQPETRDRPQSTTEVQQPPSTGFDPADRVFPIRSVVSLDPTVTPHHSGSVHSRDTISPNREGARQYSFIDEGTWNQMHSQRSSDHLYHPDPEHAEPTIPTGIPRHETHAIDGRTEIATHSLASEVVQHPEIYAKPAPSDNQSGNGSTAPPSSNTQRRNAEDHVHVTARFKHVMTDSGHAVITGRDGGAFQYCEDEPIRIPGAIQSFGLLIALREESPNQLIVRIVSENSADFLGYSPKQLFELKNFCDILSEDQVDTLLDHVDFVRDDAHDPSIDGPEVFNMSIRTANGKRCKFWCATHVSQTQKDLIICEFEREDDEVNPLNVAGLATPAVPADTLGIIPTPDQLAASTINISQPLRVLRNARRRRGEASPMEAFSILTQIQEQLGRTNNLDQLLNTTAGLVKELTGFHRVLIYQFDSSWNGMVVAELVDPNTTIDLYKGLHFPASDIPAQARELYKINKVRLLYDRDQVTSRLVCRTLEDLEFPLDMTHAYLRAMSPIHVKYLAHMKVRSSMSISVNAFNDLWGLISCHSYGNAGMRVSFPIRKMCRLLGDTVSRNIERLSYASRLQARKLINTVPTEANPSGYIIASSDDLLQLFDADYGVLSIRDETKILGDNNNSQEVLALLEFLRVRHLDSVLASHDIVKDFPDLYYAPGLKAISGLLYVPLSTGGSDFIAFFRRGQLTEIKWAGNPYEIEKRKQTAGYLEPRESFTAWRETVLSQSREWTETDVETAAVLCLVYGKFIKVWRQKEAAMQTSQLTRLLLANSAHEVRTPLNAIVNYLEIALEGALDDETRESLTKSHSASKSLIYVINDLLDLTNTEKGQDLIKDETFDLESTFREAADMLSGDAKRKNISYTVSVHPGIPELVLGDQRRVRQVLSNVISNAIQHTKSGAVTTEIWRSNGQTIPGHVGVEMTVVDTGVGMSHDKLQRLFHELEQVSTDDTYYPEEEEENTQNLPQKRVLGLGLALAARIVHNMHGQLGVRSEEGKGSRFKIILHFRLPEGTTVDEDADGMSPGVAIPATPMLSDKEFTLVSGAHESRDARRRSSESLRSGASSRSGHSGRSARSHADRLISAMQEPPLKRSTSQDLDLRRLNLSSSPASASSNNVHPPLASPSAVKRSLTMQDPHSSLSSVTHTPPLMLQPLVSPPPPGLENITDSGVPMGALRMSQHFASLGSPPIEPTKEDNSYFPRVSSIAETSQAPSSGPASSAPASSAPPTTVPSTTDSDPLSVLVAEDDPINSKIIQKQLTKLGHTVELTNNGEACTIAFASATKYFDVVLMDIQMPILDGMRATRAIREFESKTPKEALSEKAIHNDRVPIFAVSASLVEKDRDNYIDIGFDGWVMKPINFARLNILLSGICDSSARKAATYTPDGEWENGGWFDTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W6PRZ9</accession>
    <name>W6PRZ9_PENRF</name>
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        <submittedName>
            <fullName evidence="7">Tho complex subunit 7/Mft1p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PROQFM164_S01g000802</name>
    </gene>
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        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
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        <lineage>
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            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the THOC7 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1365484.W6PRZ9"/>
    <dbReference type="OMA" id="QFLHNAN"/>
    <dbReference type="OrthoDB" id="205166at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000445">
        <property type="term" value="C:THO complex part of transcription export complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008501">
        <property type="entry name" value="THOC7/Mft1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23405">
        <property type="entry name" value="MAINTENANCE OF KILLER 16 MAK16 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23405:SF5">
        <property type="entry name" value="THO COMPLEX SUBUNIT 7 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05615">
        <property type="entry name" value="THOC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="220"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="123"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="229"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="319"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM26993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="340" mass="38089" checksum="E3D10DBC3F37138B" modified="2014-04-16" version="1">MASYGLLGQPEEDALHKSRLLNVEEKPFKRISKRLLNPDSLIVSRSSLPLTPPPEETDADSDATATEAEKQKRLEEWHHFREDVALDFATFEGSIARVQFLLTSNEQERQRYATERVQILSTMQSVRESTADLRTQLEEARRLLSLRKTYDELTDKITSNRLLKPREDQSANLQKLRLEIADLEKESKDYAMTWAERREQFGRIVDEGMQLRRLIRDEKEEVERREGMQEGEDGDEGDVTSKGKASSGNTPPGPENDAMTPSQHGQDDAGRPSGLQVQKPGAAGAASPLRQVTTAQGDGAREDTNMLDEGEISAVSDGELSELEEGEELPDDFSGKMDTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W6PS60</accession>
    <name>W6PS60_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Nucleotide-binding, alpha-beta plait</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PROQFM164_S01g000514</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PS60"/>
    <dbReference type="STRING" id="1365484.W6PS60"/>
    <dbReference type="OMA" id="EFPVDRY"/>
    <dbReference type="OrthoDB" id="252020at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061574">
        <property type="term" value="C:ASAP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12365">
        <property type="entry name" value="RRM_RNPS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034201">
        <property type="entry name" value="RNPS1_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15481:SF0">
        <property type="entry name" value="LD23870P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15481">
        <property type="entry name" value="RIBONUCLEIC ACID BINDING PROTEIN S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="96"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="177"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="49"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="84"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="235"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="265"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="278"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM26705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="288" mass="32670" checksum="424999DC8038296D" modified="2014-04-16" version="1">MSSRSARGQSPLRSPEQDQARSRSLHRSKPRSESPSRSLTRSPSQGRHDRYRSRTRSRSPSRGRTRSRSPSRAGRRHNSRSESRSITPNASPPRSSKIVVEKLTKNVTENHIREIFGGFGEIEYLDLPINKAFMTNRGTAYIIYYDPADAEAAIAHMHEAQLDGAILNVSIVLPRRKFSRSPPPASNRVNGGRPRYGRVPYAGPSSPRRHGGGRPTDRHDIYRPKTASRSRSPVRSRSYSSRSRSPALRRGSPRTESRHHRRRSPSYSSYGYSSRSRSPNRNRGHNRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W6PT62</accession>
    <name>W6PT62_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S01g000745</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PT62"/>
    <dbReference type="OMA" id="KFMERWG"/>
    <dbReference type="OrthoDB" id="5314201at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM26936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="508" mass="57089" checksum="7A072E2F9ACDF23D" modified="2014-04-16" version="1">MEDTLTDKLISIFKDRDIPAKREVIESSFEDDRNAQWAAKHLRPDTLLSKDELALYIKLVNSGALQPIISNPDLGATRPILEDELRNAIESLEASTATIQKQTEALKLQCASLNKQLGLENNVELQRSRDITRLQKKHEAGRQNTTMAAIELVGELEAEFRTATDKSGAESKRILASLSTRLKQDDKALANLETLMSNIKYRGNDASTVKRTNHLSAMLSGYVAEEIHYRLDRLYLETIHGGGSNSDATYEATNTALEEEIESLYPEIEILAEMSTRQQFHEPILRELQNEHDQLRVVSQEKLERALDMLIEMTLSKQDLTNQLGVRESSSELLEQLAALYQSEAGSELVTQPSSRRESLRRRSLQPGFLLAPRTPTAPVVAQPSLERLLRRVGVPPESILHPRENGGVGDLHEKRYHISETLHGLNIAVDAPLLTYLAPLDNASQLLRYSLHANSHYETSLRDPSEESALSSLEKELASLQNGAQKLNLDVLHHRDSNQARLIERWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>W6PTC5</accession>
    <name>W6PTC5_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">O-acyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PROQFM164_S01g000820</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Sterol O-acyltransferase that catalyzes the formation of stery esters.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Endoplasmic reticulum membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PTC5"/>
    <dbReference type="STRING" id="1365484.W6PTC5"/>
    <dbReference type="OMA" id="RCHDYRR"/>
    <dbReference type="OrthoDB" id="10039049at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004144">
        <property type="term" value="F:diacylglycerol O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019432">
        <property type="term" value="P:triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004299">
        <property type="entry name" value="MBOAT_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014371">
        <property type="entry name" value="Oat_ACAT_DAG_ARE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10408:SF7">
        <property type="entry name" value="DIACYLGLYCEROL O-ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10408">
        <property type="entry name" value="STEROL O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03062">
        <property type="entry name" value="MBOAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000439">
        <property type="entry name" value="Oat_ACAT_DAG_ARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="168"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="281"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="330"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="392"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="425"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="456"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="16"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR000439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000439-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CDM27011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="498" mass="56269" checksum="904AA46A2546DBB1" modified="2014-04-16" version="1">MATRTGSVKSAREESQLNSTNGAIQNETEVSPPSTSTTRKRSKYRHVAAYHSEARHSSLSREADVLPNFLGFRNLMVLVLVAMNLRLVIENFMKYGVLICIKCHDYRRQDVVLGSILFASVPCHLLVAYIIELSAATAAKRTVGRQKKTEKEKEHDQKVFQSTWPYTAFLHTLNATLCLTVTSFVVYFYIHHPGIGTICELHAIIVWLKNCSYAFTNRDLRLALLNPSADPGLPEIYSSCPYPRNITINNLAYFWLAPTLVYQPVYPRTASIRWSFVAKRLAEFVGLAVFIWLLSAQYATPVLLNSIDKIAVMDIASILERVMKLSTISLIIWLAGFFALFQSLLNALAEVMRFGDREFYTDWWNSSSLGMYWRSWNRPVYLFMKRHVYSPLVGRGWSPLAASGMVFTISAILHEMLVGIPTHNFIGVAFFGMMFQLPLISLTAPLENMRGPEGRVIGNCIFWVSFCLVGQPLGALLYFFAWQAKYGSVSRMVSNVGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>W6PW21</accession>
    <name>W6PW21_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DENN domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PROQFM164_S01g001792</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PW21"/>
    <dbReference type="OMA" id="RCEEWRK"/>
    <dbReference type="OrthoDB" id="6019893at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032483">
        <property type="term" value="P:regulation of Rab protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00029">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001194">
        <property type="entry name" value="cDENN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004146">
        <property type="entry name" value="DC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005112">
        <property type="entry name" value="dDENN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043153">
        <property type="entry name" value="DENN_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051696">
        <property type="entry name" value="DENN_Domain_GEFs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037516">
        <property type="entry name" value="Tripartite_DENN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005113">
        <property type="entry name" value="uDENN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12296:SF21">
        <property type="entry name" value="DENN DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12296">
        <property type="entry name" value="DENN DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03107">
        <property type="entry name" value="C1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03455">
        <property type="entry name" value="dDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02141">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03456">
        <property type="entry name" value="uDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00801">
        <property type="entry name" value="dDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00799">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00800">
        <property type="entry name" value="uDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50211">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="UDENN" evidence="7">
        <location>
            <begin position="232"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="6">
        <location>
            <begin position="866"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="57"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="724"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1048"/>
            <end position="1114"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="371"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="93"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="728"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="781"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="794"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1048"/>
            <end position="1058"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM27981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="1114" mass="123209" checksum="8D0536325578950E" modified="2014-04-16" version="1">MPPPPSTPEGAPLADYFWIAGVDGAEILDTFQRLGEDYRANGTASPGPALADTIQEDADAEEEHNPDGFTRPNSTLFTGVSHRGSSQRLSTLSKNSEGANGAGSNSNRSSMTVKGGSSPLRAPNLFSEDFDFDSALYKFANERESFLTDLSLSAGAITPNTRPRSRVRTQKIVSEDSPSAGGNLLRSGIGSVRRSFRDMNSMKRQPSIARQASVRTSRRLSNYNSVIPVPQPLEISPTMHPLKRRFEPVLLDRYPTRGMPDEMKLRGNFPDYVPMFAFPNDVNIVSSDQRPRSTWHGFAMTTDNGSRLHAICVLVWIPLNPNAAEELEKRCEEWRRDNMTDEERELAASLGERLASERAKLSRLLAQLPTVQSGSESREQLEDDISAVEEKIGLMTDLLRPVRHGAASKIEGLTDGDTGFWIPRAYGILGRESTMTSFWKEWLKAVVVPMTESSVQHVPPPSPRMGVWQPLERYVMNLCTEAFCPISSKTQVEIAIRELRLFARKEAPNEIPGSRNTDLYALFRTLSVPNIIILFEYALTESRIIFLSSHTSMLYLATRALVDLLFPLEWTGVLIPVLPARLIQALEAPCPYIVGIERRYEKVELPTDDFVLVDLDNNMIESTIQPTSLPRHQRRKLLSLLQLAAPQHGRCHVPTGPPAYAIETYPWDSFMSESKATFTSKAPATNLAKYVGLNSSAFGASAVTPGSYTPPIFNVFLHARAEGGPSRGYSSRGTERPGTSSTLRVSASPPSPRENSPTSGFFPPPTSSSRNDSGMALQASLREKRSGHFDAASRRSSSFGMGRRPSAPFLGHASNLSLSTLNTDYGAGSTYAPSVYAQSTIAASTIVPQSTYQPVGNNEGTCWAEGHYFQVQPWDDKLTCAICDELAEENMYKCSACRLTVHNRCASMVCLPCDAAFHPDQIRAAFVRCFASLFYTYKKFLVPASGDKKKSGMFYNFNMDAFMKSLPSEHAEYIAILQQTQGFNEFISDRERTNPKTKDPRMTLFDEIVLSKRNRGRTSIFSGRSTTDFLSDTSNHIWRTANATFFPPSSRSQQNISSDYGRGVRTRAPANLDPSLMTEPRMIHGAPRVSKTANTARRKPLPKLMNGLAVSPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W6PWS5</accession>
    <name>W6PWS5_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein mL44</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PROQFM164_S01g002519</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ribonuclease III family. Mitochondrion-specific ribosomal protein mL44 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PWS5"/>
    <dbReference type="STRING" id="1365484.W6PWS5"/>
    <dbReference type="OMA" id="YLYSPGN"/>
    <dbReference type="OrthoDB" id="67027at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19873">
        <property type="entry name" value="DSRM_MRPL3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000043">
        <property type="entry name" value="60S ribosomal protein L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044443">
        <property type="entry name" value="Ribosomal_mL44_DSRM_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044444">
        <property type="entry name" value="Ribosomal_mL44_DSRM_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11207:SF32">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11207">
        <property type="entry name" value="RIBONUCLEASE III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22892">
        <property type="entry name" value="DSRM_MRPL44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00636">
        <property type="entry name" value="Ribonuclease_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00358">
        <property type="entry name" value="DSRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00535">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50142">
        <property type="entry name" value="RNASE_3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RNase III" evidence="8">
        <location>
            <begin position="91"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM28708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="402" mass="44440" checksum="1A162FB5797891C8" modified="2014-04-16" version="1">MKRLQLQRWSSSVLSPRARTANRLHQHIYGQRYQSTAPPVQTRDDPTIQIFEEPAVLDEQLAQIVKDSHTRHSQLQYPSPPVEAARQSAKLAALHARLYLPSRLPVETLARTLVDASADPNPNFNNASLATLGHDLLSYYATEHLICTYPRLPLTVIFAAMYAYAGPKTLAAMAREWGVDLAALPGGEVDPGLLQFQRLEPGTELASGPNHPTARPYEAQKNWRKTVTSKIFYDDEFGDPLKGIKQSAAGVTTEQASAEFVRAVMGAIYLHAGRAAAKRFFEQHFLSRHLNISELFNFQAPARDLTRLCARESFERPVAKVISETGRKSRHPVFVVGIFSGQDKLGEGAGASLMEGRERAAVAALKGWYLYSPLSVRVPSAMEEPSAAPWKPVHVDLGEVIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>W6PWV1</accession>
    <name>W6PWV1_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="13">ATP-binding cassette sub-family D member 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">Abcd2</name>
        <name evidence="13" type="ORF">PROQFM164_S01g000248</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PWV1"/>
    <dbReference type="STRING" id="1365484.W6PWV1"/>
    <dbReference type="OMA" id="IHDMYLD"/>
    <dbReference type="OrthoDB" id="422637at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005324">
        <property type="term" value="F:long-chain fatty acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015910">
        <property type="term" value="P:long-chain fatty acid import into peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007031">
        <property type="term" value="P:peroxisome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042760">
        <property type="term" value="P:very long-chain fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03223">
        <property type="entry name" value="ABCD_peroxisomal_ALDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050835">
        <property type="entry name" value="ABC_transporter_sub-D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11384:SF67">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY D MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11384">
        <property type="entry name" value="ATP-BINDING CASSETTE, SUB-FAMILY D MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06472">
        <property type="entry name" value="ABC_membrane_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="176"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="531"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="793"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="812"/>
            <end position="821"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDM26439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="821" mass="91945" checksum="2CA2AF03B8DB2694" modified="2014-04-16" version="1">MAVQSTLRRPEDPLLTLYRHYSDLIRSKFHRTSKTTRLIATIALLFSIIGSGYGGYTWFRARAKERAQGSRLLRRNSGIRGKDGSRTIYVPYKDSLTSKVLIHPTKPTTFDAHRRLFLNPPASSRSKDDGSASQIPPPTTKPGLNLAFLHQFLSLGSIMVPRWGSKETGLLMSHGLFLLMRTYLSLLIARLDGEIVRDLVAGKGRAFLWGIFKWCGIGTLASYTNAMIKFLQSKVSIAFRTRLTRYIHDLYLTDNNNYYKLMNLDGGIGQGPDQFITQDLTLFCSAAASLYSSMGKPLVDLFVFNYQLYRSLGPLALSGILAGYFSTAVVLRKLSPPFGKLKAVEGKKEGDFRGLHSRLLANAEEISFYGGADTERVFLVRSFKELQRWMEGIYSLKIRYNMLEDMILKYSWSAFGYLITSLPIFLPAWGGSGGAMELADVSEGMGRERGRMKEFITNKRLMLSLADAGGRMMYSIKDISELAGYTSRVYGLIATLHRVHADAYYTPRGSHPELYSLADVQGTTHNGFNGVRLEQVPIVAPSLYPMGGDELIESLSFIVHSGDHLLISGPNGVGKSAIPRIVAGLWPVYRGLVSRPRGFGLDGIMFLPQRPYLSVGTLRDQVIYPHTELDMREAGETDAALQKILDDAHLGYLPQREGGWDARKEWKDVLSGGEKQRMGMARLFYHEPRYAFMDEGTSAVSSDVEGLLYDNAKERGITLITISTRASLKKYHTYNLTLGLGAEGEAWEFERIGTEKEKLGVEKELQELRMRLDKVDEWKQRREEIDQELQKVWANGSEVAPPPYQEAEHSSSEALTGVTAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>W6PX66</accession>
    <name>W6PX66_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="10">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PROQFM164_S01g002361</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PX66"/>
    <dbReference type="OMA" id="LNWSIGF"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000061">
        <property type="entry name" value="MFS sugar transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF68">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="163"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="192"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="282"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="321"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="348"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="381"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="418"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="446"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="19"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDM28550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="542" mass="60631" checksum="FC6E2264FE6F3F2B" modified="2014-04-16" version="1">MFGIPKFFGWRGRSLNLAISSLGSLDFLLFGYDQGVTGGLLDLPSFIKYFPDINPLDPAIADNKPLRSQRSLNQGIAVASYNLGCFFGAVLTIFIGNPLGRRRTIFCGCMIMATGALLQCTAYSLPHFIVGRIVTGVGNGMNTSTVPTWQSESAKAHDRGKMVMIEGMLITGGITLSYWINYGMSFIGEKEVAWRFPLAFQIIFAIIIFCSILNLPESPRWLVMQGRTDEALEILECLNEKTRDDPYIKNELIAIEETVKEMNKGSYRSLFKMSEYREFHRVALAYVNQMFQQISGINLITYYAPSLYAEIGLGSGNLPKLLAACNGTEYLMAAFIPIFIIEKVGRRPLMLIGAAGMSLSMAILAGTNYRLTVLNDSRAGIGQAVFLFVFNTFFAIGWLGMTWLYPAEIVPLRIRAPTNALATSANWIFNFMVVMITPVAFENIGYKTYVIFAVINAFMFPCVYFFFPETRYRSLEEMDAIFKKSSNVFDVVTISVKEPYRYDKHGELKPEYLEEATRHASTDVHIAGAKFDSDESGHEVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>W6PXB9</accession>
    <name>W6PXB9_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Transcription elongation factor SPT5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">spt5</name>
        <name evidence="13" type="ORF">PROQFM164_S01g000418</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 9">The SPT4-SPT5 complex mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing. This complex seems to be important for the stability of the RNA polymerase II elongation machinery on the chromatin template but not for the inherent ability of this machinery to translocate down the gene.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the SPT4-SPT5 complex. Interacts with RNA polymerase II.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the SPT5 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PXB9"/>
    <dbReference type="STRING" id="1365484.W6PXB9"/>
    <dbReference type="OMA" id="YPVGYMN"/>
    <dbReference type="OrthoDB" id="28901at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032044">
        <property type="term" value="C:DSIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032784">
        <property type="term" value="P:regulation of DNA-templated transcription elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06081">
        <property type="entry name" value="KOW_Spt5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06082">
        <property type="entry name" value="KOW_Spt5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06083">
        <property type="entry name" value="KOW_Spt5_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06084">
        <property type="entry name" value="KOW_Spt5_4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SUPPRESSOR OF TY 5"/>
        <property type="match status" value="1"/>
    </dbReference>
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        </location>
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            <begin position="1"/>
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        </location>
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    <sequence length="1026" mass="111252" checksum="738A33CDB9E0D5B8" modified="2014-04-16" version="1">MSNFLNQDFGSEDEEDDFNPAPQEESDAEDLKVKPTKKEHSGGDGADEQDDVKYPRDTHANEEDDAKDVEDDEEIENEVDDDDEEEDEDEEEDVASRPQKRMKRVANPFIEDEAGVDDEEDEADDEEDELAEYGMETHPDDLDALPQGTETDDRRHRQLDRQREIDASMDAEKQAQMLKERYGRNRAAATDSLVIPKRLLLPSVEDPSIWGGRCKPGKEKEVVYSIQKRIEERPAGSRNPIRIISAFERGNIMQGWFYCEARRQADVTEGLEAINFYYPSQKLTLVPVKEMPDLLRVQKSEELLPGGWIRIKRGKYMGDLAQIEEVETNGLNVTVRLVPRLDYGMNDDAFGAPAADAKRKRGAVNTVRPPQRLFSETEAKKKHAKYLSSTSGLGGKSWNYLNDNYVDGFLIKDMRVQHLNAKNVNPRLEEVTMFARGGEDGTANLDLASLAETLKNSTAEDSYQPGDPVEVYRGEQQGLIGRTVSTRGDIISLQVTEGELAGQTIDAPVRTLRKRFREGDHVKVIGGSRYQNELGMVVQVKDDTVTLLSDMSMQEITIFSKDLRLSAEMAADGQLGIYDVHDLVQLDAATVACVIKVDRESLRVIDQNGSIRNILPTQIANKIEPRRDAVATDRNGAEIRSGDTVREVYGEQRSGVIRHIHRSFLFLHNKAQAENAGISVVRTTNVVTVSARGGRPTGPDLTKMNPALAMQTPGGGAAMPPPRRGRDQLIGKTVTIRKGRYKGLVGIVRDADDSSAQVELYTSNKPVHIPREILTPKDPVSKQPLSMGRGRGGGGPGGRTPHTSSGGPGRDSWAGGRTPIAADSSRTPAWSGAAARTPAWGGLNGSRTPAWKNDGSRTANPYDGNRTAYGGVGSRTPSWTSGSKTPYDSSSGFDAFASGSRTPGWNAGGATGGRTPGWNSMSGGRDQRDFDDAPTPGGNYSAPTPGAYAAPTPGAPTPGGWAESAPTPGGAFSAPTPGGPSKRDYDAPTPAAFDAPTPAMGGMAATPGAGYGGNDGGPRYDDSPSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W6PXX1</accession>
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            <fullName evidence="1">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
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        <name evidence="1" type="ORF">PROQFM164_S01g002601</name>
    </gene>
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        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
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        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CDM28790.1"/>
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    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM28790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="103" mass="11157" checksum="522D9B618AC6FA93" modified="2014-04-16" version="1">MLCVESAEIAGTLVALSVPAVKPVLGNLFSHMAEYTLNLDYRASIGIIHLAAGIQRLACACLPLMQQNFASTLSEIPVGSLSGAERAEKGRNPFSWIEEYRTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W6PY03</accession>
    <name>W6PY03_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">PROQFM164_S01g002945</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
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                <person name="Brygoo Y."/>
            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
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    </dbReference>
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        <source>
            <dbReference type="EMBL" id="CDM29133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="63" mass="6929" checksum="3360E32111574ED9" modified="2014-04-16" version="1">MMIVPADVCRHSHPPCLGRQGAFLPHLPPDDAPFFHSGTAQHLYSSPRYGDLEIMVPTYPGQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W6PY13</accession>
    <name>W6PY13_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S01g002467</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the aldo/keto reductase family. Aldo/keto reductase 2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PY13"/>
    <dbReference type="STRING" id="1365484.W6PY13"/>
    <dbReference type="OMA" id="TAPNYWH"/>
    <dbReference type="OrthoDB" id="2310150at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19075">
        <property type="entry name" value="AKR_AKR7A1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050523">
        <property type="entry name" value="AKR_Detox_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364:SF4">
        <property type="entry name" value="NAD(P)-LINKED OXIDOREDUCTASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364">
        <property type="entry name" value="NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="3">
        <location>
            <begin position="12"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM28656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="347" mass="39107" checksum="89093D1C18F7D9D8" modified="2014-04-16" version="1">MPLIAQQLQPRVILGLMTFGPTEAKDARITSLDEFNKCLDYFQQQGFNEVDTARIYIGGEQEAFTAKANWKSRGLTLATKWYPNQPGFHKPEVVRENLELSLKELQTDVVDIFYLHAADRATPFAETLEAVNQLHKEGKFVQFGLSNFTAFEVAEICVLCAERGWVRPTVYQAMYNAITRNIETELVPACHRYGLDIVVYNPLAGGILSGKYKSQDIPAEGRYSDAGSAGPRYRKRYFRDATFEALSIIEPVVEKHGLTLVETALRWIRHHSALRMDNGGRDGVLVGVSSFEQLKTNLADLQKGPLPEEVVQALDQAWLVAKATSPNYWHLDLKYTYDTQKAVFGPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W6PZI7</accession>
    <name>W6PZI7_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">EKC/KEOPS complex subunit BUD32</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">Atypical Serine/threonine protein kinase BUD32</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">EKC/KEOPS complex subunit bud32</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PROQFM164_S01g003480</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. BUD32 has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit KAE1. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptional coactivators.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the EKC/KEOPS complex composed of at least BUD32, CGI121, GON7, KAE1 and PCC1; the whole complex dimerizes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Telomere</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PZI7"/>
    <dbReference type="STRING" id="1365484.W6PZI7"/>
    <dbReference type="OMA" id="NPANIDQ"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0158">Chromosome</keyword>
    <keyword evidence="13" id="KW-0418">Kinase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0779">Telomere</keyword>
    <keyword evidence="13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="44"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00019973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDM29668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="182" mass="21451" checksum="25A0F0345CC05CD1" modified="2014-04-16" version="1">MRSYDKGETWEFSSGIPEFLYTIVIFQDGDDYFWSHQPKKEHLLENPANIDQSLFQKIPPEHIWPRLYDNLTIYKNTHKAFSKYLLEEAHICQFLREYPMEHPHENVTCYLGCVVKDDRITGLCFQKHADTLGDRLRDGRSVDKESCLEQVRAGIDHLHALNLVHNDLRQDNVMFADRDNKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>W6PZJ5</accession>
    <name>W6PZJ5_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">4-aminobutyrate aminotransferase</fullName>
            <ecNumber evidence="3">2.6.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">GABA aminotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Gamma-amino-N-butyrate transaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">gatA</name>
        <name evidence="13" type="ORF">PROQFM164_S01g003272</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>4-aminobutanoate + 2-oxoglutarate = succinate semialdehyde + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:23352"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57706"/>
            <dbReference type="ChEBI" id="CHEBI:59888"/>
            <dbReference type="EC" id="2.6.1.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.19" evidence="3"/>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PZJ5"/>
    <dbReference type="STRING" id="1365484.W6PZJ5"/>
    <dbReference type="OMA" id="GLMCAFD"/>
    <dbReference type="OrthoDB" id="10260828at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034386">
        <property type="term" value="F:4-aminobutyrate:2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009450">
        <property type="term" value="P:gamma-aminobutyric acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000029">
        <property type="entry name" value="4-aminobutyrate aminotransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004631">
        <property type="entry name" value="4NH2But_aminotransferase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00699">
        <property type="entry name" value="GABAtrns_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43206:SF1">
        <property type="entry name" value="4-AMINOBUTYRATE AMINOTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43206">
        <property type="entry name" value="AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="7 11" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDM29460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="497" mass="54856" checksum="6135F4A2F3649E32" modified="2014-04-16" version="1">MSSVFRASTRLRSAARLPAARALSTTASLRAEKPFFPNEPSAPSVSGSLPGPKNKAAAAELDEVFDVRSLNMLADYYQSVGNYIADLDGNKLLDVYAQIASIPVGYNNPHLKQVAASPEMACALINRPALGNFPSSDWAEILKTGVLRAAPKGLNQVFTAMAGSDANETAYKAAFMYYRQMQRGGVGADFSNDELLSTMNNQSPGSPHLSILSFKSAFHGRLFGSLSTTRSKPIHKLDIPAFDWPQAPFPQLKYPLEEHVQENTAEEQRCLAEVERLIKEFHNPVAAVVVEPIQSEGGDNHASPAFFQGLRDITKRTNVLFIVDEVQTGVGATGKFWAHDHWNLTSPPDMVTFSKKAQTAGYYYGNPALRPNKPYRQFNTWMGDPARALIFRGIIQEIERLDLVENTRTTGDYLYAGLAGLAQKYPEHFQNLRGKDHGTFIAWDTPKRDQFTAKAKSFGVNVGGCGPSAIRLRPMLVFQKHHADILLEKIEQIVQNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W6PZL6</accession>
    <name>W6PZL6_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Acyl-CoA dehydrogenase, N-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PROQFM164_S01g003297</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM164</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PZL6"/>
    <dbReference type="STRING" id="1365484.W6PZL6"/>
    <dbReference type="OMA" id="LAYMYAM"/>
    <dbReference type="OrthoDB" id="434771at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000002">
        <property type="entry name" value="Acyl-CoA dehydrogenase fadE12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050741">
        <property type="entry name" value="Acyl-CoA_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083:SF13">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE FAMILY MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083">
        <property type="entry name" value="MEDIUM-CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0274">FAD</keyword>
    <keyword evidence="4 7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="10">
        <location>
            <begin position="18"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="9">
        <location>
            <begin position="146"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="8">
        <location>
            <begin position="260"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDM29485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="446" mass="49069" checksum="51603230A6A6D188" modified="2014-04-16" version="1">MSASSRIPPIAQPFVSEQAKRTLDLVEEFVEKDCIPADIVFSAQLGEGEQRWKTNPAILESLKEKAKKIGLWNMFLPKNHFSQGAGFSNLEYGLMAELLGKSKIASEATNNAAPDTGNMEVFAKYGNDAQKKQWLEPLLEGKIRSAFLMTEPEVASSDATNIELDIRREGNEYVLNGSKWWSSGAGDPRCAIYLVMGKTDASNPDTYKQQSVILVPAGLPGITVHRMLTVYGYDDAPHGHGHISFKDVRVPASNMVLGEGRGFEIIQGRLGPGRIHHAMRSIGAAERALEWLIARVNDERKMTFGKPLVAHGVILEWIAKSRIEVDAARFVVLNAAIKIDQGNAKGALKEIAQAKVLVPQTALTIIDRAVQAYGAAGICQDTPLAYMWAMIRTLRIADGPDEVHLQQLGKRENKTRKDAVIAKLNWQRAEADRLLVASGFKPKSHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W6PZL9</accession>
    <name>W6PZL9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aromatic prenyltransferase, DMATS type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S01g003515</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the tryptophan dimethylallyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PZL9"/>
    <dbReference type="OMA" id="EYFYPAL"/>
    <dbReference type="OrthoDB" id="5392033at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009820">
        <property type="term" value="P:alkaloid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13929">
        <property type="entry name" value="PT-DMATS_CymD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033964">
        <property type="entry name" value="ABBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012148">
        <property type="entry name" value="ABBA_DMATS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017795">
        <property type="entry name" value="ABBA_NscD-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03429">
        <property type="entry name" value="arom_pren_DMATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40627">
        <property type="entry name" value="INDOLE PRENYLTRANSFERASE TDIB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40627:SF3">
        <property type="entry name" value="PRENYLTRANSFERASE ASQH2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11991">
        <property type="entry name" value="Trp_DMAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000509">
        <property type="entry name" value="Trp_DMAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00036">
        <property type="entry name" value="Aromatic_Prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01162">
        <property type="entry name" value="I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="3">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>dimethylallyl diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>dimethylallyl diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>dimethylallyl diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>dimethylallyl diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>L-tryptophan</name>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="267"/>
        </location>
        <ligand>
            <name>dimethylallyl diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="269"/>
        </location>
        <ligand>
            <name>dimethylallyl diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="271"/>
        </location>
        <ligand>
            <name>dimethylallyl diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="354"/>
        </location>
        <ligand>
            <name>dimethylallyl diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000509-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM29703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="425" mass="47783" checksum="DCCF320A1ABF6A3A" modified="2014-04-16" version="1">MTVSSTVQPLKASVPAVAQTADMPHRTLSKSMTFANLDQYQYWHAVGPMLGRMLSNGNYSIHQQYEYLCLFAHIIIPKLGPFPGGRDIYKCLLGGTGSVELSQNVQKSGLTARIAFEPTGYIASTGVDPLNRHTVHATLAELRAIGSATIDMELHQMLVTELTLTDREERLMSPGQISGTAWKTQILLALDLGQSGGITVKEYFYPALKASVTGQSVARLCFSAIRKVDKEGIFESPSKVIETYMQTQTQTDLYFLSCDLVDPAQTRIKLYLMELDMRLAKVEEHWTIGGKLNDEETLLGLQMLRELWVEFGIIEGMRNEPERPSLPGDPDTIVPFIMNYEMNPGEVLPKPKFYFPLVGISELKIANVLTAFFERYDMPEQAAVYRDNLQTYYPSKDLAVATDHQAWLSFSYTKKKGPYLTMYYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W6PZP6</accession>
    <name>W6PZP6_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit WBP1</fullName>
            <shortName evidence="8">Oligosaccharyl transferase subunit WBP1</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PROQFM164_S01g003337</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER).</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the oligosaccharyltransferase (OST) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endoplasmic reticulum membrane</location>
            <topology evidence="8">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the DDOST 48 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PZP6"/>
    <dbReference type="STRING" id="1365484.W6PZP6"/>
    <dbReference type="OMA" id="AHDEYPR"/>
    <dbReference type="OrthoDB" id="29105at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018279">
        <property type="term" value="P:protein N-linked glycosylation via asparagine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005013">
        <property type="entry name" value="DDOST_48_kDa_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055459">
        <property type="entry name" value="OST48_MD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055457">
        <property type="entry name" value="OST48_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10830">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE 48 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10830:SF0">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE 48 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23358">
        <property type="entry name" value="OST48_MD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03345">
        <property type="entry name" value="OST48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005151044" description="Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit WBP1" evidence="8">
        <location>
            <begin position="19"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="420"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="OST48 N-terminal" evidence="9">
        <location>
            <begin position="25"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="OST48 middle" evidence="10">
        <location>
            <begin position="302"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF23358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDM29525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="454" mass="50488" checksum="BAB00C0A8FB36810" modified="2014-04-16" version="1">MRWCLALLICCFLAAVNALSSSGSRLLAILEDTEQKDLYSTLWADLEARGYDVSIESSKSEQLALFKLGERAYDHLLIFPPKSKGLGPSLTPKHIVDFMNKDGNILLALSGKSATSSAISSLLLELDIHLSNDRSQVVVDHFNYDTLSAAEKHDVLVLQRPGPLRSDVKAFFDGEGVLALPRVAPQTLGDSALLSPILKAPATAYSYNPKEGTPAPEDILATGSQLNIISAMQARNSARFTVLGSVESLEDKWFSASVKTPSGKKTPTVNREFAKQLTAWAFKETGVLKVDKVEHRLITEGAELNPSIYRIKNETIYSIEISEYVYDKWVPFELPGDDALQLEFTMLSPFHRLNLEPVERTDSSTVFSTQFVTPDQHGIFSFRVNYKRPFLTAIEEKLEVTNRHFAHDEYPRSWAITGGWVWIAGLWSVIGGFLAFVVVWLYSAPVADKLKKTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q0C3</accession>
    <name>W6Q0C3_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Phosphoribosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PROQFM164_S01g003213</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q0C3"/>
    <dbReference type="STRING" id="1365484.W6Q0C3"/>
    <dbReference type="OMA" id="GKDYCAE"/>
    <dbReference type="OrthoDB" id="363185at2759"/>
    <dbReference type="UniPathway" id="UPA00057">
        <property type="reaction ID" value="UER00099"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004631">
        <property type="term" value="F:phosphomevalonate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006695">
        <property type="term" value="P:cholesterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019287">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005919">
        <property type="entry name" value="Pmev_kin_anim"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF25">
        <property type="entry name" value="PHOSPHOMEVALONATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04275">
        <property type="entry name" value="P-mevalo_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="6">
        <location>
            <begin position="305"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="903"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="908"/>
            <end position="920"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM29401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="1112" mass="120478" checksum="83BA810BA8EE8277" modified="2014-04-16" version="1">MATLESLKCALRQKATATGSSPNQPLSDIQYNAGLDILLQGPTYQDFIIPQISRLLAPLLDSNIQISVLEIGPGSKSVFGYLSGRLRRKIRKYTAFEPNGLLATGLEKWLCSKSEAESPLPCLESSPDVQRILFGVESDTNSTDTRDKDEKFDVILSCHGMHDMMPKTRFIGQALEMLVKQPEGGMVVIFHRDLTLHLDGLACHRTACFPMGAVRVANSDEILDSFAPFIAGFAMRDVEADKDTRIEWREVCRALGRSEAHPDHLLFSSPNIMSAFTHHATALPELTAQVPLLEGGKAVKNREARLHHPASTVRPTEVRQIQQCVKWALKHGANLTVVGGGHSGHCLCPNVVSVDMSAFEQVHIITAEDSGLESGLDSVPLVVAEAGCKVGDIVRKTMAAGMTVPLGARPSVGAGLWLQGGIGHLARIYGLACDAIVGAVMVSVDSSQAFCIGRVPSQHWPAGAVRPENEADLLWAIKGAGTNFGIVVSVTFQAYAAPMFSIRNWVVPLSDNLEAQGRLSNFDKLVARLPRNYSMDAYLYWDLGKLHLGVTMFESSTNGRTSGTSISTPTPAATLFEREDKFQVVDCVGLFDADMYMSGMHSGQTSTNTSAFKRCLFLKSIGVMNVAKILLAAVETRPTPLCYLHLLQGGGAISDVAADATAFGCRDWDFACVITGVWPRDQDGTEVAQAAVRWVYKVASDLLPTSSGVYGADLGPDPRDAALAAKAFGSNRPRLARLKRSSDPHNVLAYTCPLPKAPIEHKLVILVTGVSGAGKDYCADIWVSVFLEHTQKMIMARAVSISDATKREYAAATGADFNRLLQDRGYKEEHRPALTAFFQNQVRHRPRLPEEHFLNVVNGAGDVHVLLITGMRDEAPVAAFSPLVPGSRLLEVRVNSSKAARLARRGCHGGDSDHGDKENGSRPGLVFNNDATGNDAARRFAEEYLIRFIDGDLQRLANMVRPVPDFPRPGVEFRHVLNICQQPGGLALCTSLLQTHFTGEWAKVDVIVRKLPPPTVSVLKSTSHISSTSSSNENRIEIEQDLIPRGASVVVVDDVLSTGNTLCAVLQLLGEVGIADVSVMVVAEFPVHRGREGLRQRGFGVNVQSLLVFDGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q0Z8</accession>
    <name>W6Q0Z8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Short-chain dehydrogenase/reductase SDR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S02g000372</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q0Z8"/>
    <dbReference type="OMA" id="HRNVPKD"/>
    <dbReference type="OrthoDB" id="5296at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051468">
        <property type="entry name" value="Fungal_SecMetab_SDRs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544:SF12">
        <property type="entry name" value="NAD(P)-BINDING ROSSMANN-FOLD SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM30223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="278" mass="30182" checksum="FB5164E65DA10B01" modified="2014-04-16" version="1">MLSAAHGFALVTPASRGLGFAFAQQLLTRTELPVIATARKNCDELKERLLASKGMPKDAEQRLRILQVDVTDESTISAMADTIRQKYPNTPLRLGLTIPGILHAEKSPSQIDAANALESFKVNSLGPLLLLKHLSQFVPLRSAPKFPTIEVSSAINSQGPLGLPSHAIYAMMAARVGSISDNASGGWYSYRASKAAVFQLAKTFDLYLRTKSAERAIAVALHPGTVHTEFTKDYWGTREMLEPADAADKLLEVLVGLSPEAKGGRGRCWDWMGKEVLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q122</accession>
    <name>W6Q122_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Checkpoint protein Rad24</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PROQFM164_S02g000159</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the rad17/RAD24 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q122"/>
    <dbReference type="STRING" id="1365484.W6Q122"/>
    <dbReference type="OMA" id="YNKREDP"/>
    <dbReference type="OrthoDB" id="10265971at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000077">
        <property type="term" value="P:DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004582">
        <property type="entry name" value="Checkpoint_prot_Rad17_Rad24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057927">
        <property type="entry name" value="RAD24-like_helical"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12172">
        <property type="entry name" value="CELL CYCLE CHECKPOINT PROTEIN RAD17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12172:SF0">
        <property type="entry name" value="CELL CYCLE CHECKPOINT PROTEIN RAD17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03215">
        <property type="entry name" value="Rad17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25812">
        <property type="entry name" value="RAD24_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Checkpoint protein RAD24-like helical bundle" evidence="9">
        <location>
            <begin position="513"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="150"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="793"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="30"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="56"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="165"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="802"/>
            <end position="818"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF25812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDM30010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="837" mass="92094" checksum="54642388E79AEECD" modified="2014-04-16" version="1">MDGGRPPKRQRRSKDLKQDEPKRQSKRKAIIISDSSSPIEPAEPFALSSRPKPSYSRGTTPSTRLPSSSPSPIKRTKSPAKPDSDSKSKSLHNFFPPATEGQRWAPQKTEKQSLPPVTETVDVDLIEDDYDSYDEIFTQHLANERMGLAAMGSSQTRQPAPKPAPKPKPKASVKPPRKTTKRFLLSTDSGNGTAKEALAAQPASEPDRRPWAQRFAPANLGELAVHKKKVSDVQHWLEDAFAGRRPERLLVLRGPAGSGKTTTMSLLSESIGYDIVEWKNPPVSEFGARDHQSVSAHFEEFLGRGNKFGGLDLGNATEPDSQKDEKPRDQRILLIEEFPTVFGRASSTLTAFRTSLQQYLAAAANDHARGSSGSNHPPIVIIVSETLLSSASSISDNLTVHRLLGPTIYNHPGTTILDFNSIAPTFMHKALRSILDREARNSRRVQIPGPGVIDSISEIGDIRSAISSLEFLCLKGDETGRWGGSVAKTKKARGEVALTPMEKESLKLITQREASLGMFHAVGKIMYNKRMDPSLIEGDVEILPPPPDYLRHYARPKASQVLVNDLVDETGTDISTFISALHENYIPSCDGDNFTDSLNDCIDALSDSDILSADRRPGQGARAGIGTGITSFSSGTDVLRQEEISFQVAARGLLFALPYPVNRRVGSGAGRSRAGDAFKMFYPASLRLWREAEEIDGLIDSWMNRTLDPRRQHLSQNGSGLTGVSSWKNLQVGRSISADSGNKNDTPSVVTMMPRHDLLLHQLPYMAAIRRQDPDWWQLDKITSVRSNENLRNDDIDDIEESPASRSRGKQSSSRGFGPRLQLPEEKLILSDDDIVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q1D0</accession>
    <name>W6Q1D0_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Auxin efflux carrier</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PROQFM164_S01g003564</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q1D0"/>
    <dbReference type="STRING" id="1365484.W6Q1D0"/>
    <dbReference type="OMA" id="VLWFTMM"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004776">
        <property type="entry name" value="Mem_transp_PIN-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31794">
        <property type="entry name" value="AUXIN EFFLUX TRANSPORTER FAMILY PROTEIN (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31794:SF4">
        <property type="entry name" value="AUXIN EFFLUX TRANSPORTER FAMILY PROTEIN (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03547">
        <property type="entry name" value="Mem_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="115"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="144"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="235"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="276"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="323"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="356"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="388"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDM29751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="422" mass="45906" checksum="9B68936B1366C7C6" modified="2014-04-16" version="1">MSSEGLVTPFLGALQACVSVLLTMGYGFAARRLHLLQETTINDMLGLGMKLLLPALLIVNLGEQLHLQTAMNYIPVIILYTSASISLGHLSSYLLGLPQWVTPACSFNNTTSLPLLLLHSLGSVGILKLILRHGETTSSAISRAQSYFLVCGVISKTIAYVVGPRMLQDRGDGLSSSEERHHILAQDEQLTEETSLLPQRAQQARTSAGNLIRRSTHWLGSLFPHRVKQELLAPFEYPLADVAIICMIVGTVLGLVPALHRAFFNDEDDGGIFTAWLTASVSNIGGLFTTLQIFMVGCRLGVTFERTVAEGNSARIPIKAITTIFVVRLVIWPALSISLIYGLAKRTRLLGDDPMLWFSMMLMPAGPPALVISGLVELAQASEMEKMVIAKTLTIMYALSPFICFSITGALKASEAVLKEKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q3D3</accession>
    <name>W6Q3D3_PENRF</name>
    <protein>
        <submittedName>
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        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CDM30476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OMA" id="ACHVAID"/>
    <dbReference type="OrthoDB" id="4344543at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="264"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM30476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="308" mass="33120" checksum="B07ECD9766558642" modified="2014-04-16" version="1">MRSGLDKPGALPLLILIVFSLLTLVPSLPSLYHSKFADFSFYTGAVRHVPLLQDGVTELAPKAPPLNEPRKSWVLAASHRSRGNRPPVTARVGNAAVVPPSETTAVANKSRLASSTRESSFSFSRRARAFRTYFIQQLDDYPFLASFSNRSLVTGLTHPDSTITINESLPTASDIESLPNILSYNNSSDSIQTPLLPSPASFRDMFQQACHVAIDFGKRVGLHGANYAKSIFPAEQINGASKLLIPESTIPNAAASNQDLITASEQAPPQQKVGAEDSTDAAAGRHSHELHGSCMAVVIGLVAGIMWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q3I8</accession>
    <name>W6Q3I8_PENRF</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein family, basic secretory protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">PROQFM164_S01g002520</name>
    </gene>
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            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR33321">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR33321:SF12">
        <property type="entry name" value="PLANT BASIC SECRETORY PROTEIN (BSP) FAMILY PROTEIN"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF04450">
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        <location>
            <begin position="16"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM28709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="320" mass="35378" checksum="7D7BF845AFF02F7E" modified="2014-04-16" version="1">MTSSAHAPHASAIPKGNTQEQEPQTSSSKGEKQTKLTTNLTLPVPQPKLRLHVEDLRHPASSAFLAFIPDLASTLDRALANIIKHLYTSPPKSENPHRPIFTPSIPPTRSVTVFLRDYSGVAYTTGTELDDAHKEIHVSLPYIQHCTSGPSAKEDPLHELVGVLTHELVHCYQHTAPPSSLKNNGEDIPRPPGGLIEGIADFVRLKAGLEPPHWKRPLSAAERPPKWDMGYQHTAYFLAWLEDVRVGRGAVGMLNDRLLRVGYVGEGEDADNQGIGFWKGLFGVRVGELWEEYGRYLDDPTEVCVGRSSGNWEDEILNPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q3L9</accession>
    <name>W6Q3L9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="3 4">
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
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            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q3L9"/>
    <dbReference type="STRING" id="1365484.W6Q3L9"/>
    <dbReference type="OMA" id="MASNWGS"/>
    <dbReference type="OrthoDB" id="4369598at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004879347" evidence="2">
        <location>
            <begin position="26"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="473"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="115"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="185"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="479"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="501"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="539"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM30561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="586" mass="60473" checksum="0AA7AD375D1E15C0" modified="2014-04-16" version="1">MVAWMRFKLLLAMVTALVTMAAASAECQYIETVFLQDPHTGEQYQFVNVLPRALFGRAIQASELITVTVTHTTCDPDESTTTVTTDVPCTTVQSTTLLTTEITPVPAQSTPAPGVPQSTVPTTSSTPVPVNTQTSVPIVPSATRVTTKSSAPGTTLVTSQSSLPGTAQTPVPSTTKVPIGSSPVTNPGSSTVTATTTESVSSSSPNATSLAPIPVTTEIPGTTGSITSTRPTNVVPIPGTTGIAYTNSTVPQAPRTVTDVTTFYTTSSCLNSTELAPAPVTTEITITVEVPCTETTKCVSTKVLTTGTLPALNTTVPASIPRTTTTTEIQSTISVPVPITTEEVTGTVEIPCTGTTKCTSTKVYTTIPTETTTISVTPVPITAPQPTTEVVTMVQPTVPGAPAKETTEVVTTVIQPTAPAPVSQGTTELVTTVNQPSVPAPVPQTSTHEVTTEIKPTDLVPLPHATTVEATSLVKVPAPSTQPATTQETTENQPVAAAPTTLATSTVSKPEVESTTTESKISVVSPQQPTHTQEDTVLPSPHGTSSSGTHSASPVFNGANAAAIMDSRVFAMSIVIMLSHIFRLIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q3X9</accession>
    <name>W6Q3X9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g002640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q3X9"/>
    <dbReference type="OMA" id="SWEPYSP"/>
    <dbReference type="OrthoDB" id="5398515at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="286"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="382"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="70"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="134"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="343"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="396"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="417"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="441"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM28829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="463" mass="50440" checksum="770AD210F7BEF019" modified="2014-04-16" version="1">MASTPPPPSPSKLRVPRAPRHGAKHDNYEPYPTRYSARLAGQRASRVQTTPPPSHPSTSAKHGAAKRTLSPSSPGTTKPSPKKGAHSHRTAASRISPFDSELSLPRTSAQHTSRSSAERALPTPAKTPSKKKVISSGSSTSRSLFPSTSTPKRRKMETPKYSAAESLDIFVDEPLRAYNIETAEQELGISIHEDSRDRIPVIGPLSTDSFVTKARAVGRPATRSTTSHKNGAYFVQRGKKIFKRFDDMEDEGEDEDDLGLFANRPDLLADNPDILKSVKPLRRGDIKPRILFPEPAEPTDKHADPTDGAEEDVTDVEDHEPTSPTPAYEDQTYLTPPVLPDLSTPSFESETSSVYHTAPVRRTGLRFHRPAVDDVTPFSFSEDVSFGSSNGDQARSRGLSVSSGSSLLKYWPSVSRKTREAEARTDRTKRLRDARGSPAPRTRQAARAEASAASTAEASTSDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q4C1</accession>
    <name>W6Q4C1_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Dimethylaniline monooxygenase, N-oxide-forming</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PROQFM164_S02g001623</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FMO family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q4C1"/>
    <dbReference type="STRING" id="1365484.W6Q4C1"/>
    <dbReference type="OMA" id="CFEKQSD"/>
    <dbReference type="OrthoDB" id="66881at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000960">
        <property type="entry name" value="Flavin_mOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000332">
        <property type="entry name" value="FMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00419">
        <property type="entry name" value="ADXRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDM31473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="487" mass="53408" checksum="3D21C094D597DD07" modified="2014-04-16" version="1">MSESVRVAVIGAGISGVVTAGHLLAAGIQVTVFERNNATGGVWIYDKRTPIEAQYPSPRPSASQEYVKDEREGNERKVLLHAPPGPCYESLTNNVSTPLLRTKLNAWPEGTAPFVKHNVLKEYIQDTSKKAGVDDITKFGARVTRVHKDGPKWTVHWSTLSEGQDPTEKEESATFDSVIVASGHYHTPLVPNIRGLPEAKAQWPERIFHSKSFRRSEGFKGKNVLLLGGGVSSLDIATEISGTAHHVYQSTRNGAFDLPESALPENASRIAEVEAFEPSTSTSANTEHLPLTVHLKSGETLHGIDTIILCTGYQMALPFLDEYNDYTSSAAEANDTVLVTDGTQVHNLHQDIFYIPDPTLAFVGIPFYTATFSLFEFQAIAVTAFLSGVAQLPSTASLRTEYENRVKEKGLGRSFHSLKDKEQPYVEELIKWVNTGRAERGLPLIEGHTESWITERAALTERLKLILAGKLPRADILKSPLEVGVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q4J7</accession>
    <name>W6Q4J7_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Crh-like protein</fullName>
            <ecNumber evidence="15">3.2.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">PROQFM164_S02g001713</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the glycosyl hydrolase 16 family. CRH1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.2.-.-" evidence="15"/>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q4J7"/>
    <dbReference type="STRING" id="1365484.W6Q4J7"/>
    <dbReference type="OMA" id="QTPMNIH"/>
    <dbReference type="OrthoDB" id="4781at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02183">
        <property type="entry name" value="GH16_fungal_CRH1_transglycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017168">
        <property type="entry name" value="CHR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF27">
        <property type="entry name" value="GLYCOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037299">
        <property type="entry name" value="Glycosidase_CRH1_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="17" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="8 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="21" id="KW-0430">Lectin</keyword>
    <keyword evidence="11" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="9 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 19" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="19">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004879904" description="Crh-like protein" evidence="19">
        <location>
            <begin position="22"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="20">
        <location>
            <begin position="23"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="252"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="252"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="277"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="16">
        <location>
            <position position="121"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="16">
        <location>
            <position position="125"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="27"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00038074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR037299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR037299-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR037299-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="CDM31563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="437" mass="44423" checksum="FECD26A060074F11" modified="2014-04-16" version="1">MPSFMKFATAAFAVATPFVSAQTYSDCNPMETTCPANKGLASSSAHFDFTQASSLDQWKISGGQVPTTANGAQFTINKEGDAPTIVSDFYFFYGELSIEMKTSPGQGIVSSAFLQSDDKDEIDWEALGGKTDTVETNYFGKGDTSTYDRETWVPVSTPQDSFHTYTIQWSKESITWLIDGASLRTVKYADAQGGARFPQTPMNIHLGIWAGGAPTNGQGTIDWAGGLTDYSKGPYTMYIKSITVNNANPAESYTWSDKSGSSDSIKFTGSNAVSSRSPTTTDAATVSSSEAASTTESPSTSETPSTTEAPSTTTESTSSAPTTLATRTSISSAESTAASSSSSAESTAESTAASSSGAESTAASSSGAAGASPSGSSSSGSGSGSSSSSSPSSSSGSGSSSSASASASPTFNAAASVAATYLGPVSLLGLVTALLQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q541</accession>
    <name>W6Q541_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Homoserine acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S01g003106</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. MetX family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q541"/>
    <dbReference type="STRING" id="1365484.W6Q541"/>
    <dbReference type="OMA" id="HPILVMG"/>
    <dbReference type="OrthoDB" id="444135at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004414">
        <property type="term" value="F:homoserine O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009001">
        <property type="term" value="F:serine O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009092">
        <property type="term" value="P:homoserine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000099">
        <property type="entry name" value="Homoserine O-acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00296">
        <property type="entry name" value="MetX_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008220">
        <property type="entry name" value="HAT_MetX-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01392">
        <property type="entry name" value="homoserO_Ac_trn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001209">
        <property type="entry name" value="PRK00175.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32268">
        <property type="entry name" value="HOMOSERINE O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32268:SF16">
        <property type="entry name" value="SERINE O-SUCCINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000443">
        <property type="entry name" value="Homoser_Ac_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="140"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="401"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="14"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="51"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="427"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM29294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="528" mass="57389" checksum="C9F47EB43901EE61" modified="2014-04-16" version="1">MQSFRGAARAASRTIRTQPWRQANSPVNTAGSHRTLSAPWKTAHPLHTVSPRKSASATAESSERDSSNPAMSFPCLDAQEAKSAQLSARSLQSGPEPSYTTGRHESYHCEQPLLLDWGGVLTEFDIAYETWGQLNGDKSNAILLHTGLSASSHAHSTASNPKPGWWEKFIGPGLPLDTNKYHIICTNVLGGCYGSTGPSSLDPSDGKRYATRFPILTLDDMVRAQFRLLDGLGIKKLAASVGSSMGGMQSLAAGVLFPERVTKIVSISGCARSHPYSIAMRHTQRQVLMMDPNWARGFYYDGIPPHSGMKLAREIATVTYRSGPEWELRFGRQRADPSKQPALCPDFLIETYLDHAGEKFCLEYDPNSLLYVSKAMDLFDLGHAHQSATLKRRAASEERIAHGGDVPIGSDSACSLTLPDKPYEEQPGSTSNTTPLDKSVSADSVDGPPRDLVVGLAPLKDHPVLVMGVASDILFPAWQQREIAETLRAGGNKNVEHIELGDDLSLFGHDTFLLDLKNIGGALGKFLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q601</accession>
    <name>W6Q601_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aminotransferase, class IV</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S02g002284</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q601"/>
    <dbReference type="STRING" id="1365484.W6Q601"/>
    <dbReference type="OMA" id="VWLSNGV"/>
    <dbReference type="OrthoDB" id="5288718at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046394">
        <property type="term" value="P:carboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="entry name" value="D-amino Acid Aminotransferase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050571">
        <property type="entry name" value="Class-IV_PLP-Dep_Aminotrnsfr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42743">
        <property type="entry name" value="AMINO-ACID AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42743:SF11">
        <property type="entry name" value="AMINODEOXYCHORISMATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="D-aminoacid aminotransferase-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM32133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="255" mass="28473" checksum="C143FF6B7F003CA7" modified="2014-04-16" version="1">MTENSSSPESFEIFSSLRFDPSLPDAACRHASSYPDPQKSPYYLLAYHQDRLTAAAAHFQWDEALNWLQQDLQDFEAFLDASISDLSKAWRLRIVVNSKGKARVETNPTASIDLMSLFIPSLHTHPSEPIWHVHVDTQSTTPSGFTTHKTTARDDYTSARQRAGINSPTDLAEVLVVNPDGEVMEGSITTPYFLRDHMWITPPLSSGGNAGTTRRYALSQGFCLEHTISRDELVDGEECWLSNGVRGFIRGVIVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q6J1</accession>
    <name>W6Q6J1_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S02g002116</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q6J1"/>
    <dbReference type="OMA" id="VDILDLW"/>
    <dbReference type="OrthoDB" id="16079at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM31965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="605" mass="68244" checksum="400BF08FCE35E436" modified="2014-04-16" version="1">MRRIRKERMPLARFPVTEALYSAIRLQRGKTKDQPQYRVSPYLRRNPPVDILDLWPGGGFCSSRLNELIKPRRHILVEPNHAFHGLLTRLAKSKPCYKLVDDRIYGKADWSEFFATHLPEQGPGNREGSAIIPRNDTLLIMANLPDAVSPTDHFKPNRWFLSFMKSCLEQNGLNLYGAVRVIASLPFNGVSNMLPRSTTERTRTGVFAETIGLHNIEIATPAETENSLRWQGWDYLNDNRKLVAERAAANNIITPPDRELPPLKLVPEVVHRGKKEIPNQPRVLSDVHQRLLADIAAADEFGLSSSHETTDPNIKAIIRRRGIAFTHLTRENSAHQFREKLVNIIIKLDEMGRSFARAAADPKESVESLKALEDQIISLKSSYTTLISTSHWTIWEKHNFTIDDLRFRSVEAPKNGGLVHDRRPFEPLYIDPEEIYPRGSGRGVIYFEADPNPPVLKKAFDLPSAMVQPVLDRYYGLLAFVSNKMPVAELLTTLFPNETINSHVRDIPSLANFAERRLKPGYGPMPLPDGSTSDPAFSYQENVDYDLSGVRLRILSAETLLDIAIKYEKLPDKLPAFSFSRALGGTLTQAQLCNGANNPTGLKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q720</accession>
    <name>W6Q720_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type DNA-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PROQFM164_S02g001902</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q720"/>
    <dbReference type="STRING" id="1365484.W6Q720"/>
    <dbReference type="OMA" id="NMPEIES"/>
    <dbReference type="OrthoDB" id="1924787at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001080">
        <property type="term" value="P:nitrogen catabolite activation of transcription from RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050797">
        <property type="entry name" value="Carb_Metab_Trans_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668:SF4">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN DAL81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="18"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="58"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="87"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="123"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="140"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM31751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="729" mass="82689" checksum="E4A151F47A21D393" modified="2014-04-16" version="1">MDHSGPTGRAYRSKIKRPCDRCRLRKTACVLPEGPPCRSCFTNNKECTFKLRPRLKTRRMSTENQAPHATASYEVPNPTLQLSPDSTRLHHDPFDQDRGYSYNDPVQMWPGQHAQNEPQPDLMTRHTSMESMDDHPISPDQESPQQIGAITSPASQPVQRIRSLDLIEGSIAQFYGMSSESDPWLLRHCRYDEYGMRSLHRTHIRNVGGVPVEGLVPVHFLETEKELMLPKGSDMDNRSQKDVMQDRNQLNDMVSPEHGKRLLSLFLRFVFPAVPIISRSQLGITSGVSTAVLEKIPVHLLAAIYASAIPFAVHDSVLCVSAAYGELLSEKLWHTVYELILQETHTPKLAVLQASLLYLQQIPAGSLKALPDGPFIWSFLGSTVALAVSLGLHVEPRPWGIPPWEKRLRRRLWWAVYVEDKWRSLLTGRPSFIHPDEFDIFDLSAGDFIQDEKADEHDHNCQPLFYYTTGLARIIENLHRTFYTIKASQRVSDDFRASIDAARPIRAQLQQWYLSLPDTLRLKRGSVSNSHIASDPIEGASDLHFSYLVLEMFLYRAILRPLAQSPPPPPISDDTDPTPMGAFWLVEDLTFDTHGFDQLPAMNSMQLGEAEEATLKAAEKCAAIIVNFVGALAPHEFGSFWHPWNRICFAAVSNFVTLLLVQAPTRQHALRSRDLLELWSHTLRCQHWSHEGLMKLGLVRLNQMQIEGLENIFNLPAHVSEILRDTQQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q915</accession>
    <name>W6Q915_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Short-chain dehydrogenase/reductase SDR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S02g002642</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q915"/>
    <dbReference type="STRING" id="1365484.W6Q915"/>
    <dbReference type="OMA" id="EVMAVPW"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF152">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM32491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="310" mass="34308" checksum="B86CE5C9AF7FE845" modified="2014-04-16" version="1">MYRHSPNPRGIKTNLHRIVLISGLRRGDLAAMTADVLAHGGAGTIIYTGRSKHELQPVIDHINRKYKTVKMVFVTADSGSLTSFREAAHTIKKLGVSIDGFVGFPEVMAVPWSLTEDGFESHFQRNYLCYFLLLNLLRDVMGPRSRAVLVTSSLRNEAPAPTWDDLGFENGENYHCLDGYSQSMLAIILFIKSFAKKHSGSIAAFSANPGNTKTNVQTYVGWEEVKSWLQRKKEAGEDLPVLLQQAPKSLCQGSGAVLRGLLDPELEAQSGAFLDHCQTPKLPHLDFPAGEESAEALWKRSQKLVEPFLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q923</accession>
    <name>W6Q923_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="6">CbxX/CfqX</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PROQFM164_S01g000046</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CbxX/CfxQ family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q923"/>
    <dbReference type="STRING" id="1365484.W6Q923"/>
    <dbReference type="OMA" id="WCQLEND"/>
    <dbReference type="OrthoDB" id="2423195at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000641">
        <property type="entry name" value="CbxX/CfxQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050773">
        <property type="entry name" value="CbxX/CfxQ_RuBisCO_ESX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43392">
        <property type="entry name" value="AAA-TYPE ATPASE FAMILY PROTEIN / ANKYRIN REPEAT FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43392:SF2">
        <property type="entry name" value="AAA-TYPE ATPASE FAMILY PROTEIN _ ANKYRIN REPEAT FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00819">
        <property type="entry name" value="CBXCFQXSUPER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATPase AAA-type core" evidence="5">
        <location>
            <begin position="21"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="373"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDM26237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="482" mass="55089" checksum="0F51073873397350" modified="2014-04-16" version="1">MVQSLRRLGLDPRTQLPFNFIFRGPLGTRKTSTARKIGQVYYDIGLLASSEVVETSATDLVGQYVGQTGPKTQQVLERGLSKVLFIDEVYRLAKGHFAKEAIDKIINSITKPRFTQRLIIALASYNADINRLISINPGLTSRFPESLQFDPLSSADYVKLVCELLLKEKGKILVKSQAQFDLVCLKSPNINFMKEMLQRFDRLSKTASWANTRDIGTLTKTIFGKLLQSFHGKKLVLSEDMVLQAFDSMILERSSREVYPQKTPSTTIQTSDKIDLALRTQSLSNLATTLKSQGSVNKDVASSKKLDTMGPETDRFTTTTTRDVGVTDDEWCQLENDKLLANAKEKEYSCLNDEEEQQKKKILKLKEEGEKAARELEDARGKADEDAKRRHEQDRLQHELERRRQERFMEKLHRQQEALAEARRKEQANQTKLKTMGVCVMEYRWIKQNGGYRCAGGSHWGRMRSLEVPDLVILKHEKIIYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q962</accession>
    <name>W6Q962_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S02g003091</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q962"/>
    <dbReference type="STRING" id="1365484.W6Q962"/>
    <dbReference type="OrthoDB" id="4327238at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM32940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="102" mass="11864" checksum="01ABECCDCE0A20C6" modified="2014-04-16" version="1">MISIRENNEYIPAALRIRFNSQQPWLDFQIDKAHVVFPATWTDMKLVLKGTSIQYDTFIHTRQQSAIEGKKDYQACFFELSPSASPVFAGPFWELNHDQSVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q9E6</accession>
    <name>W6Q9E6_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tetratricopeptide-like helical</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S02g003191</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM33040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q9E6"/>
    <dbReference type="STRING" id="1365484.W6Q9E6"/>
    <dbReference type="OMA" id="WGIKKDP"/>
    <dbReference type="OrthoDB" id="2148946at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010972">
        <property type="term" value="P:negative regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052945">
        <property type="entry name" value="Mitotic_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43628">
        <property type="entry name" value="ACTIVATOR OF C KINASE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43628:SF1">
        <property type="entry name" value="CHITIN SYNTHASE REGULATORY FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="59"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="181"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM33040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="375" mass="41176" checksum="0F96892EDFAEB331" modified="2014-04-16" version="1">MPSLRNILHKHDDLSTTQTPRNAPANPAPELKLIRTDTHTREIIVPPSYPDDPTPYPSSPSQEEPTSPRRSFQFFNRSPRRPSVSSQSPPHRERHLSSFLHHHRSRSNSRDSSANIPADLPQIEEDRGASKQEREALWEKRATVLVQHNPQFAHSGSSLPVRQGEGEASLGLGLGQGGQVGSRSSSQSRVGVDPNQDINIQEAIRLHESGDLERSTHMFEQLADPNGANNPLSQVLYGLALRHGWGCPVDATRAVTYLSAAASNSAAVEAEALRAGVKKGGVAKGELVLAIFELANCFRQGWGIAKDPAAARQYYETAANLGDTDAMNEAGWCYLEGFGGKKDKFKAAKYYRLAEENGCPTLGNSWIWKDKYNPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q9F9</accession>
    <name>W6Q9F9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S02g002807</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q9F9"/>
    <dbReference type="OrthoDB" id="10268330at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM32656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="52" mass="5855" checksum="FA10DC019DD4F597" modified="2014-04-16" version="1">MGEVPYHTLHEDGNKSIDGEAEEFIPWLNRDLGRATDIRHVAVRHFIAVSPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q9K7</accession>
    <name>W6Q9K7_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Zn(2)-C6 fungal-type DNA-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PROQFM164_S03g000037</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q9K7"/>
    <dbReference type="OMA" id="CELTTIV"/>
    <dbReference type="OrthoDB" id="2154091at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051615">
        <property type="entry name" value="Transcr_Regulatory_Elem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313:SF86">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="10"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="49"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="94"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="108"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDM33313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="655" mass="73788" checksum="A66D2E01F6C3BE34" modified="2014-04-16" version="1">MQIRKRVAVACVRCRHKKLKCDGQRPQCGNCLAKSLDCRLCVAQNNPSTSAERVLSDPEHSVTSESTPHTPLPFSRVTGIGLSRNDSPSVPTRDASHPEIPENDRRNTSLYHGPTSTVYDDTSPNYNEQNRLGPSNEEGTRHFLFSQTARQSKTGQLEPLNLAAGRLDFDGIDPDIGMHLLSIYWSRQLYTAQIIYRPAFMRDMACEGPYFSKLLLNAIFFVVSKHCDRPELRSDPNDITTAGWKFRQRFTQLLRDCFDKSEITTLQALLIMSNALFSRCDERSLSWLYAGNAFNMFIDLGLHVLPAVDSIPAEELEIRKRVLWGAYFIDKIQCLFQGRPPLLNRVNVSASLDFLDDFDELEPFQGITYMTTKPRVVVPSLNVSLLTNLCELTTIVERILREIYSESRESNLVHRANISREIKSQLRNWRENLPRRLDYLSFPDQAVLLPQSACLLALFNVLIILLHRPLITGHDGVINSTTAHESVNACTAAANQIVQILHDYSQHFSLSSAPYMLSYATYISATIHARIVAQKGSNSTMFQSLVFCRNILIEHTRLYSAAEKARENLDKLISHLGINVADDNQRAGSAGNNFPSEHMVMPESINVARESGVADRPLEFGSFQMSLELSDLDLEAIAQGFQVDVESNSFWNALV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q9Q0</accession>
    <name>W6Q9Q0_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Arsenite-resistance protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PROQFM164_S02g003287</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ARS2 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM33135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q9Q0"/>
    <dbReference type="STRING" id="1365484.W6Q9Q0"/>
    <dbReference type="OMA" id="FEDKIMQ"/>
    <dbReference type="OrthoDB" id="342064at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
        <property type="term" value="C:nuclear body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031047">
        <property type="term" value="P:regulatory ncRNA-mediated gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016070">
        <property type="term" value="P:RNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025239">
        <property type="entry name" value="DUF4187"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039727">
        <property type="entry name" value="SE/Ars2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007042">
        <property type="entry name" value="SERRATE/Ars2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021933">
        <property type="entry name" value="SERRATE/Ars2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13165">
        <property type="entry name" value="ARSENITE-RESISTANCE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13165:SF0">
        <property type="entry name" value="SERRATE RNA EFFECTOR MOLECULE HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04959">
        <property type="entry name" value="ARS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13821">
        <property type="entry name" value="DUF4187"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12066">
        <property type="entry name" value="SERRATE_Ars2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01173">
        <property type="entry name" value="DUF4187"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="666"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="142"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="463"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="549"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="773"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="49"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="486"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="784"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="833"/>
            <end position="848"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM33135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="888" mass="99549" checksum="F9C8503E6C8B5C0D" modified="2014-04-16" version="1">MDSYDGYGSPGRNRESDSFTGRATGESYRRRSPASQDRRRARPRSRSPVIDRYEPSERRSHREDFYNNSREHAAREREDRRRAPSPTVANIDRYVPGQDSSSGGKRPIPTNPMPNPLTLDFQVGFNWFAEWWRLEESVNEEKERAKNGGRRVKGEREAREDREKERAQIQAAYDTYKVDLQIRLARLFVQQHRNEEWFKERYLPEVRDPLRARLMTVRQGAYEQWEHDIENNLFKDFTLEGIYKSDSDGAGGVVEKEEGETTATAETMGVLDLLPVRGGDLRDEALAQPALLIKTLAPNVSRSKIEEFCKEHLGEEDGGFKGLSLSDPNPSKKFHRMGWIMLHPSANTTVERGDGRDEEFENMDQDGGANGGVTISPAEKALEAVNDKTIHDSVHGDFVCHVGVHVPPAQPRKKALWDLFSAPERIDRDLELAKRLTSKLDSEMNISVDGFTKIEEYVDDLRGKGELQPPATGPVSVKKQRNGYGDEGDEGEIEEGEEKEISEEEDVDDEELAVKKKKLDLVVEYLRRVYNFCFFCVFESDSVHELGRKCPGGHLRRPRTGLSTQAKEVARASALGQPFPAKKKEPSEEGEDPSSPVQEKRGQRHGSKSEQQLQRAFNWVKTFEDKLLQILEPENVDLSKLGGKPVDQALEDELLKYMKQEDDSKYRCKAPECTKLFKAEAFWRKHVEKRHTEWFNGIKNDLALVNAYVLDPARIAPSRSDANSNGHFPLGSGQGHTGTPRGFTLASMPYAPNGNMPTFPPIPGMMGSGWNGNAMGHDGGLHQPGPMRRGQNRNNRPGPYDRRRFNGNGRLSPPRGMPGMYGGRLPPPGVSVPAGHPAANMAAANPFPDSMGSSGGPMAPREAVQGRSLKSYEDLDAVDASGSGELQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W6QAU0</accession>
    <name>W6QAU0_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">peptide-methionine (S)-S-oxide reductase</fullName>
            <ecNumber evidence="2">1.8.4.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Peptide-methionine (S)-S-oxide reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PROQFM164_S03g000309</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-methionyl-[protein] + [thioredoxin]-disulfide + H2O = L-methionyl-(S)-S-oxide-[protein] + [thioredoxin]-dithiol</text>
            <dbReference type="Rhea" id="RHEA:14217"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="Rhea" id="RHEA-COMP:12313"/>
            <dbReference type="Rhea" id="RHEA-COMP:12315"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16044"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:44120"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.8.4.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>[thioredoxin]-disulfide + L-methionine + H2O = L-methionine (S)-S-oxide + [thioredoxin]-dithiol</text>
            <dbReference type="Rhea" id="RHEA:19993"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:58772"/>
            <dbReference type="EC" id="1.8.4.11"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MsrA Met sulfoxide reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.4.11" evidence="2"/>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QAU0"/>
    <dbReference type="STRING" id="1365484.W6QAU0"/>
    <dbReference type="OMA" id="LFWESHD"/>
    <dbReference type="OrthoDB" id="77405at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008113">
        <property type="term" value="F:peptide-methionine (S)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1060.10:FF:000006">
        <property type="entry name" value="Peptide methionine sulfoxide reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1060.10">
        <property type="entry name" value="Peptide methionine sulphoxide reductase MsrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01401">
        <property type="entry name" value="MsrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002569">
        <property type="entry name" value="Met_Sox_Rdtase_MsrA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036509">
        <property type="entry name" value="Met_Sox_Rdtase_MsrA_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00401">
        <property type="entry name" value="msrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43774">
        <property type="entry name" value="PEPTIDE METHIONINE SULFOXIDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43774:SF1">
        <property type="entry name" value="PEPTIDE METHIONINE SULFOXIDE REDUCTASE MSRA 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01625">
        <property type="entry name" value="PMSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55068">
        <property type="entry name" value="Peptide methionine sulfoxide reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptide methionine sulphoxide reductase MsrA" evidence="7">
        <location>
            <begin position="6"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM33585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="174" mass="19559" checksum="EE6268174A35F9AF" modified="2014-04-16" version="1">MPGTETATVAAGCFWGVEHLYRKNFGNGKGLLDAKVGYCGGPVPSPTYRAVCSGSTGHAEALRIVFDPSIVTYRQLLEFFYRMHDPTTENRQGPDVGTQYRSAIFTHGEEQQKIAQEITDKVSKQWYKTPLSTKILPAGQWWDAEEYHQLYLQNNPAGYECPAHFIRPFPPLSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W6QBJ7</accession>
    <name>W6QBJ7_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Aldehyde dehydrogenase</fullName>
            <ecNumber evidence="3">1.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PROQFM164_S02g001684</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>an aldehyde + NAD(+) + H2O = a carboxylate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:16185"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.3" evidence="3"/>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QBJ7"/>
    <dbReference type="STRING" id="1365484.W6QBJ7"/>
    <dbReference type="OMA" id="WNFPLDM"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019413">
        <property type="term" value="P:acetate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07091">
        <property type="entry name" value="ALDH_F1-2_Ald2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000050">
        <property type="entry name" value="Aldehyde dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000026">
        <property type="entry name" value="Aldehyde dehydrogenase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000001">
        <property type="entry name" value="Mitochondrial aldehyde dehydrogenase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="8">
        <location>
            <begin position="31"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM31534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="493" mass="53879" checksum="BA7233552C05489B" modified="2014-04-16" version="1">MALFQSIKTPVLTYEQPLGLFINNEFIKGVAGRTFETINPHNEKPIVAVHEGAEEDVNIAVKAARTALNGEWKTITPSERGRLLLRLADFLERDIETLAAIEALDNGKSVTMAKGDVNNSAGCLRYYGGWSDKIYGQTIDTDSNSLTYTRHEPVGVCGQIIPWNFPLLMFAWKIGPALATGNTIVIKTAEQTPLSALYVAKLIKEAGFPPGVVNVISGFGRTAGAAIASHMDIDKVAFTGSTLVGRHIMKAAADSNLKKVTLELGGKSPNIILPDANLEDAIEWVNLGIFFNHGQCCCAGSRILVHEDIYHKFLELFKKRTEQNKVGDPFHSETFQGPQVSQLQYDRIMGYIKDGKGAGATVVTGGDRHGSEGYYIQPTIFADVDENMTIVKEEIFGPVCTVQKFSTEEEAIRVANSTNYGLAAAVHTTNINTAIRVSNAVKAGTVWVNNYNTLHYQMPFGGFKESGIGRELGSYALENYTEVKTVRVHLQKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W6QBV9</accession>
    <name>W6QBV9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="4">EF-hand-like domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S01g000946</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QBV9"/>
    <dbReference type="STRING" id="1365484.W6QBV9"/>
    <dbReference type="OMA" id="NEGDAHV"/>
    <dbReference type="OrthoDB" id="429467at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050403">
        <property type="entry name" value="Myosin_RLC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23049">
        <property type="entry name" value="MYOSIN REGULATORY LIGHT CHAIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="18"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM27137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="120" mass="12954" checksum="8803946DC2F1DB0B" modified="2014-04-16" version="1">MNFPTFLNTLSGLMASMSPSQELLNALAAFDDDDSGQIDATELRDALLHTSPEDGEERLTERQIDEVFSGFIGRPAFIGRGAKSGGMGKRGEVFQYHDFVRSIMGGDNGNSAKNEGDAHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>W6QBW4</accession>
    <name>W6QBW4_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Calcium-transporting ATPase</fullName>
            <ecNumber evidence="18">7.2.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">PROQFM164_S03g000669</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Catalyzes the hydrolysis of ATP coupled with the transport of calcium.</text>
    </comment>
    <comment type="function">
        <text evidence="17">This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. Transports the calcium to the vacuole and participates in the control of the cytosolic free calcium.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16 18">
            <text>Ca(2+)(in) + ATP + H2O = Ca(2+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18105"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="18">Membrane</location>
            <topology evidence="18">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15 18">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.10" evidence="18"/>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QBW4"/>
    <dbReference type="STRING" id="1365484.W6QBW4"/>
    <dbReference type="OMA" id="QLAVTFM"/>
    <dbReference type="OrthoDB" id="3352408at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005388">
        <property type="term" value="F:P-type calcium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02081">
        <property type="entry name" value="P-type_ATPase_Ca_PMCA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000039">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000028">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000031">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000018">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000001">
        <property type="entry name" value="Phospholipid-transporting ATPase IC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006408">
        <property type="entry name" value="P-type_ATPase_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01517">
        <property type="entry name" value="ATPase-IIB_Ca"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093:SF423">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093">
        <property type="entry name" value="CATION TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 18" id="KW-0106">Calcium</keyword>
    <keyword evidence="4 18" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="13 18" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 18" id="KW-0813">Transport</keyword>
    <keyword evidence="3" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="262"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="288"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="457"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="499"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="938"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1012"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1090"/>
            <end position="1110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1122"/>
            <end position="1141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1147"/>
            <end position="1167"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="22">
        <location>
            <begin position="231"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="20">
        <location>
            <begin position="321"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase C-terminal" evidence="21">
        <location>
            <begin position="965"/>
            <end position="1143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="26"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="79"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="200"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1200"/>
            <end position="1247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="102"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="125"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="1200"/>
            <end position="1216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="1232"/>
            <end position="1247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00038148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00059328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU361146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF00689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF00690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="CDM33945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="1247" mass="135994" checksum="6B5D88A081711835" modified="2014-04-16" version="1">MSSSNNDPSYQGSLLSPVIVTDFSGRERSMSTASSAWSGPTDLNHSPTSPVSPDMAWNPPDPARLMVQNASHRLSQSIDGDTLRPRADSFASSADTVVRSRANSEVDPTHTSKDVYDDVSLSDALRPDPRNEADFQVEDNRFAFSPGQLNKMQNPKSLAAFHALGGLQGLERGLRTDLKAGLSIDEGCLEGNVEFQDVAPSAQHTATEKSPSKPVTSAPAPVSSGHGSPFEDRIRVFSQNKLPARKSTGFLKLFWAAYNDKIIILLTIAAVVSLSLGIYETVSEGTGVQWVEGVAICVAILIVTIVTAANDWQKERQFAKLNKRAVQVTRSGKPDMVSIYDIMVGDILHLEAGDSIPADGILVSGYGVKCDESSATGESDQMKKTPGHEVWQQIVDGKATKKLDPFLISGSKVLEGLGTYVVTSVGPYSTYGRILLSLQTPNDPTPLQVKLGKLADWIGYLGTAAAGILFFVLLFRFVADLPNHPERNGAVKGKEFVDILIVAVTVIVVAIPEGLPLAVTLALAFATTRMVKENNLVRVLRACETMGNATVICSDKTGTLTQNKMTVVAGTWGSNQNFSQRTEDEDVEGSMTTSAISQKLSAPIKDLIIKSIALNSTAFEREKDGSIDFVGSKTEVAMLQLARDYMGMDLVSERGSAEITQLIPFDSDRKCMGVVYRVPGAGYRLLVKGASELMVGVCTAEIVNIDISKERPDVEQLSDEQKKNLLEIIDNYAHKSLRTIGIVYKDFASWPPIEAKHSEDPSANFEDFFHDMTWVGVVGIQDPLRPEVPSAIRKCHSAGVQVKMVTGDNVATATAIATSCGIKTEDGLVMEGPKFRQLTNEEMDEVVPRLQVLARSSPEDKRILVERLKALGETVAVTGDGTNDGPALRTADVGFSMGIAGTEVAKEASSIILLDDNFKSIITAIAWGRAVNDAVAKFLQFQVTVNITAVILTFVSSVYSSENTSVLTAVQLLWVNLIMDTFAALALATDAPTEKILDRKPVSKHASLFTMTMWKMILGQAVYQLAITFMLYFAGEKLLNAHLSSEPEMRAKQLSTVVFNTFVWMQIFNEFNNRRLDNKFNIFEGMFRNYWFLGINAIMIGGQVMIVFVGGQAFNVTRLNGTLWGVCLICSIACLPWAIVLRLIPDYYFGLVFNAVVGGMAVVLRPLSKGCKVIGRGIRSFFRPVKRFTRRIFNKRKSEDELELKPKSTDPEEAPERLQLNTQKPSPERLATPTPVVIPPITITTSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W6QC41</accession>
    <name>W6QC41_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WD repeat protein 23</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PROQFM164_S02g001875</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QC41"/>
    <dbReference type="STRING" id="1365484.W6QC41"/>
    <dbReference type="OMA" id="CFVPRGV"/>
    <dbReference type="OrthoDB" id="270624at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000457">
        <property type="entry name" value="rRNA processing protein Pwp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044285">
        <property type="entry name" value="PWP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14091">
        <property type="entry name" value="PERIODIC TRYPTOPHAN PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14091:SF0">
        <property type="entry name" value="PERIODIC TRYPTOPHAN PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="256"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="299"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="391"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="39"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="492"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="54"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="69"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="502"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDM31724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="531" mass="59130" checksum="FDA9D48A9E1139F8" modified="2014-04-16" version="1">MSSMITTTTWVRRGVAAQFPTKYEIDEAEMSRISKLARMQLEDAKDDMNAAQDGSEDEGDDAMEEDAEEKTSAKDTDSKTDDDVLKEFDMDNYDKEEIDEDGEKITMFGNVQSLAYHQPNEEDPYLVIPEDEDDEEREELQIMPYDNLLLAGKVEDEVAHLEVYVYEDKADNLYVHHDIMLPGIPLCTEWLDIPVGKNPEGRTQGNFVAIGTMEPDIEIWDLDVVDCMYPNAILGQGGQDAEKPKKKQKKKAKANDEYHIDAVLALAANRQHRNLLASASADKTVKLWDLNTATCAKSYSNHKDKVCSLDWHPAESTILLSGSYDRTVVAADMRAPDAQARWGVDADVECVRWDPHDTNFFYVTTDGGMVYRYDMRNVPATPAESKPVWSLQAHDSSVSSFDINSSIPGFLVTGSTDKTVKLWSVENDKPTLVVTRKLEVGKVFSTTFAPDQEVSFRLAVAGSKGNVQIWDASTNGAVRRAFVSRMPDLAGDVPERTVGINADDDESDDSEGEGDEGEPRGGDGWESMDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W6QCD8</accession>
    <name>W6QCD8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g001091</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QCD8"/>
    <dbReference type="OMA" id="GCRTNLE"/>
    <dbReference type="OrthoDB" id="4312384at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004881464" evidence="1">
        <location>
            <begin position="21"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM27282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="135" mass="14956" checksum="AD991DB1B705D4BD" modified="2014-04-16" version="1">MKLIQQSLLALTLLLPATIAGHPTSHPPEELQAQKYNWTFDLFHNKHCVGTAVSYAGQGSSGCRTNLENGVAEALINVNIDRSCKVKLFRDKKCSRHSMVEEIKTGSTTKCRPISRKKSTVLRYLVSDMLISLLG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2023-06-28" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W6QCN3</accession>
    <name>ANUI_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Short-chain dehydrogenase anuI</fullName>
            <ecNumber evidence="7">1.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Annullatin D biosynthesis cluster protein I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">anuI</name>
        <name type="ORF">PROQFM164_S03g001182</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>FM164</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2022" name="Org. Lett." volume="24" first="6072" last="6077">
            <title>Biosynthesis of Annullatin D in Penicillium roqueforti Implies Oxidative Lactonization between Two Hydroxyl Groups Catalyzed by a BBE-like Enzyme.</title>
            <authorList>
                <person name="Xiang P."/>
                <person name="Kemmerich B."/>
                <person name="Yang L."/>
                <person name="Li S.M."/>
            </authorList>
            <dbReference type="PubMed" id="35939524"/>
            <dbReference type="DOI" id="10.1021/acs.orglett.2c02438"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="function">
        <text evidence="4 7">Highly reducing polyketide synthase; part of the gene cluster that mediates the biosynthesis of annullatin D, an alkylated aromatic polyketide with a fused dihydrobenzofuran lactone ring system that exhibits potent agonistic activities toward the cannabinoid receptors (PubMed:35939524). AnuI does not seem to play a role within the pathway (PubMed:35939524). The annullatin backbone 2-hydroxymethyl-3-pentylphenol is assembled from one acetyl-CoA starter unit and 5 malonyl-CoA elongation units by cooperation of the highly reducing polyketide synthase anuA, the short-chain dehydrogenase anuB and the oxidoreductase anuC, before being hydroxylated at the C-5 alkyl chain by the cytochrome P450 monooxygenase anuE to form (8S)-annullatin E. The prenyltransferase anuH subsequently installs one isoprenyl group at the benzene ring to form (8S)-annullatin J. Enzymatic or nonenzymatic dihydro-benzofuran ring formation between the prenyl and the phenolic hydroxyl groups in (8S)-annullatin J results in two diastereomers (2S,9S)-annullatin H and compound 12. The intermediate (2S,9S)-annullatin H is then converted to (2S,9S)-annullatin D by the FAD-linked oxidoreductase anuG-catalyzed five-member lactone ring formation. The isomer 12 acts as a substrate for the short-chain dehydrogenase anuF and is oxidized to (2R)-annullatin F, which is subsequently acetylated by an acetyltransferase leading to (2R)-annullatin G formation. The remaining enzymes identified within the cluster, anuD, anuI and anuJ, seem not to be involved in annullatin biosynthesis.</text>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="4">Does not affect the annullatin D biosynthesis pathway.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.-" evidence="7"/>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QCN3"/>
    <dbReference type="SMR" id="W6QCN3"/>
    <dbReference type="STRING" id="1365484.W6QCN3"/>
    <dbReference type="OMA" id="QCEISEF"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43963">
        <property type="entry name" value="CARBONYL REDUCTASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43963:SF6">
        <property type="entry name" value="CHAIN DEHYDROGENASE FAMILY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G15350)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0521">NADP</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000458206" description="Short-chain dehydrogenase anuI">
        <location>
            <begin position="1"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="171"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="171"/>
        </location>
    </feature>
    <feature type="active site" description="Lowers pKa of active site Tyr" evidence="2">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="L0E2Z4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="O93868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="3">
        <source>
            <dbReference type="UniProtKB" id="Q92506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="35939524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="5">
        <source>
            <dbReference type="PubMed" id="35939524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="6"/>
    <evidence type="ECO:0000305" key="7">
        <source>
            <dbReference type="PubMed" id="35939524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM34458.1"/>
        </source>
    </evidence>
    <sequence length="252" mass="26919" checksum="4B4518D9D9DA9908" modified="2014-04-16" version="1">MAAVTKPLVLITGANQGLGFATAQQLASTGQYNLLVAARSQEKAEGAVKQLESSTNSSLTPIVIDLDQDESITAAAKFVEERFGSLDILINNAGINRSSDPNATLRESYRAVFETNVFGVAVMTATFLPLLRASKYHDRRIVNVTSGLGQIGIAYSPTSEYSAKIWELPIYRSSKSAINMISAVDAVSLEKENILVVLAAPGFCRTNFGGGQGVKSAEEGARPIVRAATEGSPKELFGKLVDDENTLVEFGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W6QDB0</accession>
    <name>W6QDB0_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Homeodomain-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S03g001403</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QDB0"/>
    <dbReference type="STRING" id="1365484.W6QDB0"/>
    <dbReference type="OrthoDB" id="2143914at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb-like" evidence="2">
        <location>
            <begin position="342"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="310"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="34"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="316"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM34678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="400" mass="44094" checksum="B095A94FA895C415" modified="2014-04-16" version="1">MSSATYRLETFRSWNPTQEKAQPSRNPVNTCRYPSPVSIAAAPSPSNPRDPLSESQKVSLPKPKLHPLPVRPPMEVCLHGDLQPHTQIVRVGPEVLEPPPPFNEDIETFDPESILHAQDLSGHGNVDHSSIFGDIGQDSEHQLPSFESGDPKLAFTAGQQSRVEAPVNPTQTEYLSDDATIDPAILDGYHFPDVRQTQAAEPTPRVAIRSSESPAGNSRFLDKDVCSRGRRHSSKGKVKPIRQLSKINKVAGVVESRGKNRTRRFACGLGCKNDVSFPTFLSWLFEGALPRCLPSPSTTNDTPVSTCISDHDEDMTPTSSNSSTSGDTVNAEHTCASRKGLPWSVEEGRLLVKLREKQNLAWPEVTKRFCQKFPGRSSGSIQVYWSTTLRKQRLSLAKDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W6QDB4</accession>
    <name>W6QDB4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S03</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S03g001408</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QDB4"/>
    <dbReference type="OrthoDB" id="4356012at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM34683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="83" mass="9055" checksum="79EB4D383AB74BC1" modified="2014-04-16" version="1">MSDGFKVRHQDHRGFSDGANHVPDQRFNRSIALWGAIGRGVPVGAQNIRPNTGCSAFRVMSSASCSLRDLEFASVVMLRVCCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W6QDJ4</accession>
    <name>W6QDJ4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="7">2-hydroxyacid dehydrogenase homolog 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PROQFM164_S03g001475</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QDJ4"/>
    <dbReference type="STRING" id="1365484.W6QDJ4"/>
    <dbReference type="OMA" id="GIFYADC"/>
    <dbReference type="OrthoDB" id="298012at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12183">
        <property type="entry name" value="LDH_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000052">
        <property type="entry name" value="D-lactate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058205">
        <property type="entry name" value="D-LDH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43026">
        <property type="entry name" value="2-HYDROXYACID DEHYDROGENASE HOMOLOG 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43026:SF1">
        <property type="entry name" value="2-HYDROXYACID DEHYDROGENASE HOMOLOG 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00670">
        <property type="entry name" value="D_2_HYDROXYACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase catalytic" evidence="5">
        <location>
            <begin position="3"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="6">
        <location>
            <begin position="110"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM34748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="331" mass="35994" checksum="F264DAEAD3F39B9A" modified="2014-04-16" version="1">MRIAVFSAQPYDKASLDQSNQAFKHEITYHEAGLSEKTALLASGFPAICVFVNDQINANVIHKLAEHGTRLIALRCAGFNNVDLAAAKKAGITVVRVPAYSPNAVAEYTLGLVLCLERKIHKAWLRVREENFALNGLLGTDLYGRTIGIVGAGRIGSLVARSFRAGLGCEVLACDIVQNPELVSIGVKYVSKEELLRQADVICLHCPLTPDTRHLLNSDTLRITKPGVTIVNTGRGALIDFVALLDGLESGHVGGAALDVYEYEKPLFFRDLSEQIVSDHTFRRLITLPNVIVTGHQAFFSRQALESIANTTLSSVGQFEKNGQVEKSVTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>W6QE72</accession>
    <name>W6QE72_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="10">GTP-binding protein rhoA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">rhoA</name>
        <name evidence="10" type="ORF">PROQFM164_S03g001765</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rho family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM35038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QE72"/>
    <dbReference type="STRING" id="1365484.W6QE72"/>
    <dbReference type="OMA" id="EVNHYIP"/>
    <dbReference type="OrthoDB" id="8830751at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01870">
        <property type="entry name" value="RhoA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000329">
        <property type="entry name" value="GTP-binding protein rhoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0636">Prenylation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDM35038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="198" mass="22084" checksum="378A1F8255BEFB85" modified="2014-04-16" version="1">MAEIRRKLVIVGDGACGKTCLLIVFSKGTFPEVYVPTVFENYVADVEVDNKHVELALWDTAGQEDYDRLRPLSYPDSHVILICFAVDSPDSLDNVQEKWISEVLHFCQGLPIILVGCKKDLREDRKTIDELAKTSQRPVSQEQGEEVRKKIGAYKYLECSARTNEGVREVFEAATRAALLKAVKGKGGRKPGKGCLIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W6QE81</accession>
    <name>W6QE81_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Galactose oxidase/kelch, beta-propeller</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S03g001775</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM35048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QE81"/>
    <dbReference type="STRING" id="1365484.W6QE81"/>
    <dbReference type="OMA" id="FGGMCPF"/>
    <dbReference type="OrthoDB" id="205993at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004879561" evidence="2">
        <location>
            <begin position="22"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="538"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="598"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="642"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="708"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="649"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="715"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="791"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="816"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="826"/>
            <end position="836"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM35048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="947" mass="101970" checksum="450F1642940DDD07" modified="2014-04-16" version="1">MKHRKAKGLLALLALGGPSTAIPYTPSSIFLSPQHNDSLAYILRPSSTGGTEFVSLNLSSSIDAENLSYQTLLKSTPFYSSDQNSSFISTINDQGFITVYSGNCHSASDKPILWEFHPNSNSPVGNGTWQKLPVITSDAKTAPNYLAAGFTYSASRNEDESSMYAFGGMCPFANSTDETWVSAANYSHSTVVLGPSPYYNTKFTAATTGKRAPPIAEAGMAVVPLQPTYAAGSTGKQQDFLFIGGHTRQAFLNMSQLAIFSLPQQSWSFVSAVSNLTPKTELTVRDTVSIEPRSGHTAVLSEDGNKVFVFGGWVGDITVPAEPQFAVLDLAEGFGGTTEWIWTAPSSEGLGITEGTGIFGHGAAMLPGGVMMISGGYTIPKSSSKRALPTTQSNPQIYLYNVTSSSWVTSYSNPAASSSNAFPHSGKLSSSQKAGLGVGLGIGCPVAIAIVLCGWNYHRKRRGKSQRDSQLRELALGAERSHFWGRDCPTQASSIRGSGMSQTRDALVYPWSANRCQTTQPNWKVQGEGTAERTGLLVDPPSLAKNNRSPMIPPVSNRPFSYRNSEYRWSDATGDIHPIDEREEDEEILREHLMASTPAETRPTVKTTEPEDPFSDTPYATPRSTIFGVGLGPFYSRRKDIGSVDPVSPTKSEQTATNLSETSTFSFASTQPVGKVNQARAILVDRPLSWGSGHQSLEYLAAGSVHSDPDGVAPSENSVSADSYSTARTNMSHRQSENESLLFDAFDPTTPSSPSPPSSPSKLPRESKPKPADWVINTMRRALTMTRRSPDSQLDSGASTTSTAHRASGIDRRSTLLGSDQQSTCSGPSSPRRAVSASAELFRRKQGAKDWNAGKRVSDDVFNTARSTRDDLFIGAPGYLGNEAGFGDDEEDVHDWDLEGAAEGRRVQITFTVPREKLRVVNATAGDVDSMSERSVSWSTGNRRVST</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W6QE91</accession>
    <name>W6QE91_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Bacterial Fmu (Sun)/eukaryotic nucleolar NOL1/Nop2p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PROQFM164_S03g001507</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QE91"/>
    <dbReference type="STRING" id="1365484.W6QE91"/>
    <dbReference type="OMA" id="QLFTEYV"/>
    <dbReference type="OrthoDB" id="6093671at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016428">
        <property type="term" value="F:tRNA (cytidine-5-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049560">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001678">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057285">
        <property type="entry name" value="Pre-PUA_NSUN2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057286">
        <property type="entry name" value="PUA_NSUN2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023270">
        <property type="entry name" value="RCMT_NCL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018314">
        <property type="entry name" value="RsmB/NOL1/NOP2-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22808">
        <property type="entry name" value="NCL1 YEAST -RELATED NOL1/NOP2/FMU SUN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22808:SF1">
        <property type="entry name" value="RNA CYTOSINE-C(5)-METHYLTRANSFERASE NSUN2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01189">
        <property type="entry name" value="Methyltr_RsmB-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25376">
        <property type="entry name" value="Pre-PUA_NSUN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25378">
        <property type="entry name" value="PUA_NSUN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02008">
        <property type="entry name" value="RCMTFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02011">
        <property type="entry name" value="RCMTNCL1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01153">
        <property type="entry name" value="NOL1_NOP2_SUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51686">
        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="3" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="SAM-dependent MTase RsmB/NOP-type" evidence="12">
        <location>
            <begin position="54"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="575"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="815"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="592"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="343"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="172"/>
            <end position="178"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDM34780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="871" mass="97132" checksum="4BA2A97B5FAA75A1" modified="2014-04-16" version="1">MGKRGGKKGGRGRGGGGGAGRTRAQWQDITRQNERFERYYNEPEFIPEEEKEAFWATMRKDLPNSFRFTGSRGHALAVQQSLKDRYIPEITSIKYEDEFVEPPRPVSWYPDQLAWSMTTPKNVIRRFAPFASFQKFLVAETDVGNISRQEVVSMIPPLLIDARPGMTVLDMCAAPGSKSAQLMELLHAGEEDAIAQVTEQIKNGTAGPEPIGPEGLNDDGRSTGLLIANDSDYKRAHMLIHQMKRLSSPNLIVTNHDATLFPSIKLPPLPTADGSKPQNRYLKFDRILADVPCSGDGTARKNVGVWKDWTPGNALGLYSTQSRILVRALQMLKVGGRVVYSTCSLNPVENEAVIATAIERCGGAANVKIIDCSQELPGLKRASGLRNWKVMDREGRMWNNWQEIEEHRDQEGINGLARLAEGMFAPTGEAANLPLDRCMRVYPHQQDTGGFFITVLEKTSEIKAKPESTNVIPKGSIAALAAELDSRKNEVNGQPLEKLESLDELVTPDEEVEEELAKNTSVAEAVHQLPYSATLDASTPASPVKRAAGDLEAEIPAKRSRLDDGTEVMLGDRPVHAPAHGVRTGLDTPDNSTPSTSAPTAQSFKKKGPRQEEPFKYLDPNHEELVPIYEFYKLSDRFPRDRFMVRNAEGLPTRTVYYTSALGRDILTCNEGHGMKFVHCGVKMFVKQDAQRENVCRWRVQTDGLKIIEPWLGPERSVVLTKRETLRRLLVEMFPKVTDDGWKSLGEIGEQVKDIPMGCSILRVQANVGEDGLPEAMVLPLWRSLYSLNLMLPKEERRAMLLRIFNDSTPLINTTQRQGVKTEPTEPTAEAEDIALKEENLEVGQEAQDEVDDRETYTKDGDEEDRFNTTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2024-10-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>W6QEA7</accession>
    <name>W6QEA7_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S01g001733</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QEA7"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM27922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="109" mass="12327" checksum="9454CBA6A49B0C8A" modified="2014-04-16" version="1">MELTVLTMEYLLRTPDTTDLNVVPLSGGKVVIGDVKSGNVSEEANSLDTSHPTLVLLHYVICFFLSRPILSKDFNDLLYPPPYVFDYEEWPRGLVAKPKSIDSEKFDTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W6QED5</accession>
    <name>W6QED5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S03</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S03g001825</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM35098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QED5"/>
    <dbReference type="STRING" id="1365484.W6QED5"/>
    <dbReference type="OMA" id="LKEHTWV"/>
    <dbReference type="OrthoDB" id="3210378at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="697"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="702"/>
            <end position="716"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM35098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="762" mass="84736" checksum="28985B47528D0BE5" modified="2014-04-16" version="1">MSVVAIRTETPVVSYNSIPGNHVDDAVHSRTSSVSSYRTNYTASTAPTTYPPSSPASSYRQCDSVNSLPKLTEPIQRRIPHEVYEVIIHHLEELHKGQHQTGCTTCFQRDLHALALTCRSWEKAVRGPLYHSIHIVGNDSPAQLKKYRLKRGSRLKLLRRTLRERKLLANLVYELRVPQLDLLFTMKQGTQWQEYRDLVASVVMVCPNLERLLGLSIPYHHEFDRLTHALSTRKKLKEHTWVLGEAARAPELSPRDDSCPGSLGPSQMFEFLDYHTSWTNLETLMLYGLNGNGALEPSISLRIFNLLPSLRNLCITSFNKDSFDNSTLMCLPPLESLRLENLPGITDAGLSQYTSRPESLSLKTLVLVEQNIKSLLVISKLLASLRGLERFKIVQTEKCPTLPDGHMVFQPILASSTLKYLHWDVACPDPGTALTQLDTLPFQKPTKPSNTPNYHLAQSIISAGFPQLEALRAPCDVEPPGALQAVCRPVLKGQALLRPDRYSLPRSSHGSVNTRPLALPAGNNLTSARIRAQTFIDMAAKDTEAGMRVLIQDYSDTYVPDNAQNSQFEEEPEQEMDDYGIWAACERFKDEANDCSGPKTVYEFRMPTLMGRSGFRDPATGASIPHFILRPDITGQEADGGLIGWKQLLASNQSLLYAAGVGVNCFGSGSPFIPPPEDIMSPASTISRFGWGSLGGRSVMGTSPTTPTTPSTPMSSVQGSALPWDKDTCTGTWNHKTGRDWWFHMERDRPGNSELVDIKQLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W6QEF7</accession>
    <name>W6QEF7_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g001783</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QEF7"/>
    <dbReference type="STRING" id="1365484.W6QEF7"/>
    <dbReference type="OrthoDB" id="4653208at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM27972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="97" mass="11001" checksum="1DF81AE9A5211FC3" modified="2014-04-16" version="1">MPYTNSSGTRVQLSFAVEFTNTLFTMTVIAWVVDKEAIPNFRSGMILGQRDCIDAIQYRSIPRSILEARGESVDEKFWGDLILESYVDFDGSLKEIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W6QF89</accession>
    <name>W6QF89_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Tetratricopeptide-like helical</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S03g001446</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QF89"/>
    <dbReference type="STRING" id="1365484.W6QF89"/>
    <dbReference type="OMA" id="LMEMSPT"/>
    <dbReference type="OrthoDB" id="414774at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45588">
        <property type="entry name" value="TPR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45588:SF1">
        <property type="entry name" value="WW DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM34721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="555" mass="62741" checksum="9E9093AC7A41B3C4" modified="2014-04-16" version="1">MDQPSPAEDYYNLGDYRRNVSTTNEDAQLWFSRGLIWAYAFNHAESIRCFEKVVEFDRTCVMGYWGIAFALGPNYNKPWQLFDGEDLSATTSRAHRAILEAKKHAPTATPLENALIDALQHRYPQEQPIEDCTEWDKNYAEAMTSVYNDYPDDLDVTALYCDALMNLTPWGLWDVKTGEVAPGAKTLEAEKALNRVFEQADSYDHPGVLHLYIHLMEMSPIPELALPKSNSLRGLVPDAGHLEHMSSHIDVLCGGYKNAVAANTSAIRADEKFLANQPLGHFYNLYRAHDYHFRIYAAMLGGRSKVALESAAELARIITEPLLRIQSPPMADWLEGFISVQMHVFVRFGRWEDIIAAELPEGADLYCVTTAMMHYAKGIAFAATSRVVEAEEERERFLGAMKLVPASRTIFNNRCIDILRVGEAMLDGEIAYRRGEYDTAFSYLREAVRRDDSLPYDEPWGWMQPARHALGALLLEQDRVEEAVAVYAADLGVDRSLPRALRHPANVWASHGYFECLIKMGQKNEARAMLPRLKADLAWADVPIKSSCFCRQRTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>W6QFQ4</accession>
    <name>W6QFQ4_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Tubulin beta chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">TUB2</name>
        <name evidence="16" type="ORF">PROQFM164_S01g002298</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 13">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4 13">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the tubulin family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QFQ4"/>
    <dbReference type="STRING" id="1365484.W6QFQ4"/>
    <dbReference type="OMA" id="WVPRSVN"/>
    <dbReference type="OrthoDB" id="1662883at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000070">
        <property type="term" value="P:mitotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097435">
        <property type="term" value="P:supramolecular fiber organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02187">
        <property type="entry name" value="beta_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000003">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000002">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000009">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013838">
        <property type="entry name" value="Beta-tubulin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002453">
        <property type="entry name" value="Beta_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01163">
        <property type="entry name" value="BETATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00228">
        <property type="entry name" value="TUBULIN_B_AUTOREG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10 13" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 13" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="14">
        <location>
            <begin position="47"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="15">
        <location>
            <begin position="246"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CDM28487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="447" mass="49921" checksum="39731DC7534F91E8" modified="2014-04-16" version="1">MREIVHLQTGQCGNQIGAAFWQTISGEHGLDGDGQYNGTSDLQLERMNVYFNHASGDKYVPRAVLVDLEPGTMDAVRSGPFGKLFRPDNFVFGQSGAGNNWAKGHYTEGAELVDQVLDVVRREAEGCDCLQGFQITHSLGGGTGAGMGTLLISKIREEFPDRMMATFSVVPSPKVSDTVVEPYNATLSVHQLVEHSDETFCIDNEALYDICMRTLKLSQPSYGDLNHLVSAVMSGVTTSLRFPGQLNSDLRKLAVNMVPFPRLHFFMVGFAPLTSRGGQSYRQVSVPELTQQMFDPKNMMAASDFRNGRYLTCSALFRGKISMKEVEDQMRNIQSKNQSYFVEWIPNNVQTALCSVPPRGLKMSSTFVGNSTSIQELFKRVGDQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQEASVSEGEEEYLAEDIVDEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W6QFU9</accession>
    <name>W6QFU9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transcription factor iws1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">iws1</name>
        <name evidence="9" type="ORF">PROQFM164_S01g002343</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Transcription factor involved in RNA polymerase II transcription regulation. May function in both SPT15/TBP post-recruitment and recruitment steps of transcription.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the IWS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QFU9"/>
    <dbReference type="STRING" id="1365484.W6QFU9"/>
    <dbReference type="OMA" id="MPAYNIQ"/>
    <dbReference type="OrthoDB" id="21124at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.930.10:FF:000003">
        <property type="entry name" value="Putative Transcription factor IWS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.10">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051037">
        <property type="entry name" value="RNAPII_TF_IWS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035441">
        <property type="entry name" value="TFIIS/LEDGF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017923">
        <property type="entry name" value="TFIIS_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46010">
        <property type="entry name" value="PROTEIN IWS1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46010:SF1">
        <property type="entry name" value="PROTEIN IWS1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08711">
        <property type="entry name" value="Med26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47676">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51319">
        <property type="entry name" value="TFIIS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TFIIS N-terminal" evidence="8">
        <location>
            <begin position="266"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="419"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="60"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="125"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="147"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00037349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM28532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="442" mass="50451" checksum="A5693BBB1A9FA3BE" modified="2014-04-16" version="1">MSASPDRKAVSPAASPEPEVLEQAATPVTGGDNEGENVTEPTAETKEVTVNADEELHGGDDDEVDDDKLSDDESILSEVDEAQFDNFDPENVDIEDRPQLAIDEDNLKLIGRHKRKRTEDGESRPRRKEGRREKKSRRADEGGDEGGSSRRRERKQREDKPETDEETLDPETRRRRALDRAMDEAMKKPAKRRFRKQDGIDLESMADAEIEDMRKRMTHAAQMDAINRQEGKPAMHKLKLLPEVIMLLNRNQYTSALVDPEINLLEAVRFFLEPLDDGAMPAYNIQRDLLTAITKLPINKDALIASGIGKVVVFYTKSKRTERRIKEMAEKLLAEWTRPILQRSDDYSKRVYQEADYDPTKVVRRAPPTAEEIRAEARALEMLPPRLLNRARVDRTNVSYTVVPRQTAVRESQFARPLGASGEDRFRKMQARQVAARKASRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W6QG03</accession>
    <name>W6QG03_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Major facilitator superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S03g001623</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QG03"/>
    <dbReference type="STRING" id="1365484.W6QG03"/>
    <dbReference type="OMA" id="LQMIRMN"/>
    <dbReference type="OrthoDB" id="330047at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052599">
        <property type="entry name" value="SLC43A_AATransporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20772:SF4">
        <property type="entry name" value="HYPOTHETICAL AMINO ACID TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20772">
        <property type="entry name" value="PROTEIN FMP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="178"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="207"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="245"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="363"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="402"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="453"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="482"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="521"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="556"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="556"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="566"/>
            <end position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM34896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="581" mass="64762" checksum="9A0F02BA8F9E9233" modified="2014-04-16" version="1">MSLVQHVSAIDGIDRELEPDLVDDCDFVPIRRKISYDVIQPPSDAIPVAETRPGTPAYKHSTTKRIAQVAVTVIACWSASGIVFGFAALKPVLVEEGVYHERCTPAEKVEGLELCAQQDLGLNLFFTIASITANVSALPVGTVLDRCGSRICWFIACLLLAIGAVIMAFAFHEPGFDGYIAGNFFLALAGTFLFVPSFQIANAFPKYAGSIVALVTGAFDASAAVFLFYRLVYEKSGRSFTPDKFFLGYLIVPVCIFIALVTIMPVRDYVSTLNLQSKLEKAEDATRDVHDSDDEIESTSELNRVRKRRAERRKKKLRQIDAVLGDRDERQMRAEREEDRQQTSWVWGVLHGLPAHKQMATPWFILITLMTVLQMIRMNYFIATIRSQYEYMLESIEEANKIGAFFDVALPVGGVLFTPVIGFLLDRLSVPTMLGLIVLFTTVIGVLNSIPAVWAGYMTVLLFVLLRPLYYSAMSDYTTKVFGFATFGRVYGAIICLSGIANFSQYGLDALTHHTFDGNPIPINVVLAIAGFIVGTSLVIFVFVSVRQLREKGRVDEEERERLLLEEDEEEDEYEDDGSYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W6QG53</accession>
    <name>W6QG53_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF4291 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S02g003326</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM33174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QG53"/>
    <dbReference type="STRING" id="1365484.W6QG53"/>
    <dbReference type="OMA" id="RDRMTWI"/>
    <dbReference type="OrthoDB" id="413653at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025633">
        <property type="entry name" value="DUF4291"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38567">
        <property type="entry name" value="DUF4291 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38567:SF1">
        <property type="entry name" value="DUF4291 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14124">
        <property type="entry name" value="DUF4291"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM33174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="198" mass="22800" checksum="007AB1AF47F83AE9" modified="2014-04-16" version="1">MPSNNYKAIRAKQTANTITVYQAYSPEIAEPALKAQTFVPPFSRERMTWIKPSFLWMAYRSGWATKARQERVLAIEITHEGFEWALRHSCLSHYTPSETSQEEWQKKLRASPVRVQWDPERDLFLRSLDYRSIQVGLSGEAVGRYIDEWIVSITDVTATMRLIDGYLKDGKVDEAKGCLPEETLFALPEHLQKSLTMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>W6QGX5</accession>
    <name>W6QGX5_PENRF</name>
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        <submittedName>
            <fullName evidence="6">Septin homolog spn1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">spn1</name>
        <name evidence="6" type="ORF">PROQFM164_S04g000571</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
    </comment>
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        <property type="protein sequence ID" value="CDM35690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1365484.W6QGX5"/>
    <dbReference type="OMA" id="RSNPMGS"/>
    <dbReference type="OrthoDB" id="416553at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032156">
        <property type="term" value="C:septin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01850">
        <property type="entry name" value="CDC_Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000196">
        <property type="entry name" value="Cell division control 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016491">
        <property type="entry name" value="Septin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18884">
        <property type="entry name" value="SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006698">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51719">
        <property type="entry name" value="G_SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Septin-type G" evidence="5">
        <location>
            <begin position="89"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="409"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="409"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDM35690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="465" mass="52683" checksum="AA4F6155668AFB8A" modified="2014-04-16" version="1">MSSPPASSSPVASPVASRDSPTPNNGTESPFVERSNPMGSGIAQTVSSRDPKAAAQAATDMKNVVRRKLTGYVGFANLPNQWHRKSVRKGFNFNVMVVGESGLGKSTLVNTLFNTSLYPPKERTGPNADIIPKTVSIQSTSADIEENGVRLRLSVIDTPGFGDFVNNDDSWRPIVENIEQRYDTYLEAENKVNRSNIVDNRIHACVYFIQPTGHSLKPLDIEVMRRLHTKVNLIPVIAKADTLTDDEVALFKQRILADIEQHSLQIFEGPRYELDDEETIAENQEIMSKVPFAVVGANSEVTTADGRRVRGRSYPWGIIEVDNEEHCDFVKLRQMLIRTHMEELKEHTNNFLYENYRSEKLTLMGVAQDPSVFKEVNPAVKQEEERALHEQKLAKMEAEMKMVFQQKVAEKESKLKQSEDELYARHREMKDQLDRQRGELEEKKGRLETGRPVEEKGKRKGFSLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W6QH24</accession>
    <name>W6QH24_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ENTH/VHS</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S03g000223</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QH24"/>
    <dbReference type="STRING" id="1365484.W6QH24"/>
    <dbReference type="OMA" id="WRQIYKG"/>
    <dbReference type="OrthoDB" id="4033880at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030125">
        <property type="term" value="C:clathrin vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006895">
        <property type="term" value="P:Golgi to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16992">
        <property type="entry name" value="ENTH_Ent3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000006">
        <property type="entry name" value="Clathrin interactor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013809">
        <property type="entry name" value="ENTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12276:SF45">
        <property type="entry name" value="CLATHRIN INTERACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12276">
        <property type="entry name" value="EPSIN/ENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01417">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00273">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50942">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENTH" evidence="2">
        <location>
            <begin position="27"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="285"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="319"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="345"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="367"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="384"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="414"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="452"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="490"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM33499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="518" mass="54670" checksum="3C869EE98BAA1A01" modified="2014-04-16" version="1">MDFSNLKDQVSNLSLYDLKAGVRKVQNAVMNYTEMESKVREATNNEPWGASTTLMQDIANGTHSYQLLNEIMPLIYKRFTDKAAEEWRQIYKSLQLLEFLVKNGSERVVDDARSHMSLIRMLRQFHYIDINGKDQGINVRNRSSELVKLLGDVDQIRTERKKAKNNRNKFSGFEGGMGAGAGMSSSGSGRYGGFGSDSMGYGGYSGGVYGDGGGFGGESGGQAGVDFQDNGRRSNRFDEYDEYDEGDAPARPRESISRAKPQAKKPEPAPAPVADLFDFGDDEPVTTTASTSTGKQPAGSALNILDPSPVDDDDFDDFQSATPVIQSSSQFAIPPPASTASTTSNTQFVAPQPISASQGANINGLVGFTSASPAPSSSGFATPVSQMAPIQQQKPSGYQAPTPNYFTSVNVAQSSGSSHGATSSMSSVASPTANKPASAAAKKPSGDVFGSLWSTASASAGIQKTNTGTNKGPNLASMAKEKASAGIWGTPAPSSTASTPSQPQHKQQSSSAFDDLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W6QHM0</accession>
    <name>W6QHM0_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S04</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S04g000806</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QHM0"/>
    <dbReference type="STRING" id="1365484.W6QHM0"/>
    <dbReference type="OMA" id="CYLFDCC"/>
    <dbReference type="OrthoDB" id="4760831at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="347"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="347"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM35925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="388" mass="43859" checksum="5D9CC969E2269B2F" modified="2014-04-16" version="1">MTTSKTPDSFQAHKARKRLDQFSTDLETAINHATKFKPYRKTAVIAFHWENDDIGVEPLERELLDVFKSVYGFETESFTIPLIESQFKLLERLVSWSRRSSGEDTLRIFVYSGHAGFAGTVASRWDLAGKCDQYTGNLQGPNLNWWEIRGYLEQYTGEVCYLFDCCSGGSGALSAYHGAEFIAASTWDQTAVLNVHFSFTRILIDELHQLNGQAETLASIYSRIFRYTQQNQIGAAPIHIPKPNSPSVTIGCNRSRPVTRSVDRESYRVLLSIKVREEIPLDFTQWKEWLTRNIPANVLSTNVTVEGAFRGSSLLLFTVPIEIWTMMPADDPSYTFIGHVTSHNLLSQRPTQTSTLTSTLPMHSGAPSRRKNQPPRSPNRKPFGSPKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W6QI49</accession>
    <name>W6QI49_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S04</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S04g000991</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM36110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QI49"/>
    <dbReference type="OMA" id="FRTHDWA"/>
    <dbReference type="OrthoDB" id="3796275at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM36110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="112" mass="12650" checksum="F811EDFBBC4EF303" modified="2014-04-16" version="1">MPEKVLSKDAVKSALPGLRIAPNTTKFSALHNIRYTGRVSRWQSFDADVWASMSTSWSQAIIDYKIDGRDLREEEVYVADETGVQGRFEQSVGQILGAVFRAQHVNIRFADF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W6QJ18</accession>
    <name>W6QJ18_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">D-amino-acid oxidase</fullName>
            <ecNumber evidence="8">1.4.3.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PROQFM164_S05g000611</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a D-alpha-amino acid + O2 + H2O = a 2-oxocarboxylate + H2O2 + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:21816"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:35179"/>
            <dbReference type="ChEBI" id="CHEBI:59871"/>
            <dbReference type="EC" id="1.4.3.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:21817"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Peroxisome matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DAMOX/DASOX family.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.3" evidence="8"/>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QJ18"/>
    <dbReference type="STRING" id="1365484.W6QJ18"/>
    <dbReference type="OMA" id="VHFQECE"/>
    <dbReference type="OrthoDB" id="409956at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003884">
        <property type="term" value="F:D-amino-acid oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019478">
        <property type="term" value="P:D-amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.9.10:FF:000018">
        <property type="entry name" value="D-amino acid oxidase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006181">
        <property type="entry name" value="D-amino_acid_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023209">
        <property type="entry name" value="DAO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11530">
        <property type="entry name" value="D-AMINO ACID OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11530:SF16">
        <property type="entry name" value="D-AMINO ACID OXIDASE (AFU_ORTHOLOGUE AFUA_5G11290)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000189">
        <property type="entry name" value="D-aa_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51971">
        <property type="entry name" value="Nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00677">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="11">
        <location>
            <begin position="6"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>D-dopa</name>
            <dbReference type="ChEBI" id="CHEBI:149689"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>D-dopa</name>
            <dbReference type="ChEBI" id="CHEBI:149689"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="329"/>
        </location>
        <ligand>
            <name>D-dopa</name>
            <dbReference type="ChEBI" id="CHEBI:149689"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00039101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000189-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDM36778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="356" mass="37933" checksum="CB5CCE6B93B7FAA1" modified="2014-04-16" version="1">MPEKTVVVIGAGVAGLTTALLLSKCPGYKIIVAAKHMPGDYDIEYASPWAGANYMPVSIRGTEAAEWEKATWAPLEDLARNHPEAECEIHRREKDAGSATADWFAELLSPEPWFKDTVPDFRPLPKSSLGPGVDAGTVFTSVCINTAIYLPWLVSQCLKNGVTFKRAVFSHILEAAGPSVCPGKVDFVVNCTGLMASKLGGVNDKTVIAARGQIVVVRNEAGKMVDVSGTDDGDGEACYVMTRAAGGGTILGGCYQKGNWDSQVDPNLAIRIMKRAVELCPALTGGRGIEHLDIVRHGVGLRPVREGGVRIERERVGDLWLVHNYGAGGAGYQSSYGCAQAAIRLIQDAAGPQSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2024-10-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>W6QJ55</accession>
    <name>W6QJ55_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S01g003429</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QJ55"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM29617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="49" mass="5560" checksum="51CFADB1242A8026" modified="2014-04-16" version="1">MLPIYILISINIKYTAPRKDQDPGADAGDIQLDYKNRSVYKNTPFPTFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W6QJ78</accession>
    <name>W6QJ78_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">methylcrotonoyl-CoA carboxylase</fullName>
            <ecNumber evidence="2">6.4.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">3-methylcrotonyl-CoA carboxylase 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">3-methylcrotonyl-CoA:carbon dioxide ligase subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PROQFM164_S04g000957</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>3-methylbut-2-enoyl-CoA + hydrogencarbonate + ATP = 3-methyl-(2E)-glutaconyl-CoA + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13589"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57344"/>
            <dbReference type="ChEBI" id="CHEBI:57346"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.4.1.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid degradation; L-leucine degradation; (S)-3-hydroxy-3-methylglutaryl-CoA from 3-isovaleryl-CoA: step 2/3.</text>
    </comment>
    <dbReference type="EC" id="6.4.1.4" evidence="2"/>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM36076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QJ78"/>
    <dbReference type="STRING" id="1365484.W6QJ78"/>
    <dbReference type="OMA" id="QGGIIKH"/>
    <dbReference type="OrthoDB" id="439921at2759"/>
    <dbReference type="UniPathway" id="UPA00363">
        <property type="reaction ID" value="UER00861"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004485">
        <property type="term" value="F:methylcrotonoyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006552">
        <property type="term" value="P:L-leucine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000021">
        <property type="entry name" value="Acetyl-CoA carboxylase carboxyltransferase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011762">
        <property type="entry name" value="COA_CT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045190">
        <property type="entry name" value="MCCB/AccD1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22855">
        <property type="entry name" value="ACETYL, PROPIONYL, PYRUVATE, AND GLUTACONYL CARBOXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22855:SF46">
        <property type="entry name" value="METHYLCROTONOYL-COA CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50980">
        <property type="entry name" value="COA_CT_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CoA carboxyltransferase N-terminal" evidence="6">
        <location>
            <begin position="28"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="7">
        <location>
            <begin position="300"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00025711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00026116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00031237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00031404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00052347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM36076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="557" mass="60292" checksum="23508E5EFEA4DC0C" modified="2014-04-16" version="1">MATESSFPVANTNIDLRGSQFQANKESWTPVLDRFEEALKQVSAEGNDVSLRRHISRGQLLPRDRVALLLDQDSPFLELGAFTGFGNEDSTPCGNLIAGIGNVCGRICLLMSHIPTQSGGAWNEMTVLKVNRMMEIAFENDLPLISLVQSAGVFLPQQFKVFHKGGQLFRDLALRTRHGKPSCAIVFGSSTAGGAYHPALSDYTIFVENQAQAFLGGPPLVKMATGEVIGAEELGGAKVHAITTGLADQIASDEYDGSGFCQILILTRAYRFDAIHKSREWVASLQARVPSVPGLIGSLPPRYPIEDVLSIVNPDIRKPFDMREVLLRIVDDSRLSVFKPKYGPNMITASAHIMGFPVGIVANQLSVINPNEAAKATQFIRMCNQQHTPIIFLHNVTGFMVGAKAEHAGIIKMGAQLVSAVSCSTVPHISIILGASYGAGNYAMCGRAYSPRFLFSWPTGRCSVMGPDQLSGVMENVQIASAKSKGLTLSPEKLKKQVSSFRDRVAKDAECYSTSSMLIDDGIIDPRDTRDVLGMCLEVVSQPGVNGTQTHNLLARI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W6QJF1</accession>
    <name>W6QJF1_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major facilitator superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PROQFM164_S04g001022</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM36141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QJF1"/>
    <dbReference type="STRING" id="1365484.W6QJF1"/>
    <dbReference type="OMA" id="GTPKYRC"/>
    <dbReference type="OrthoDB" id="4139357at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17316">
        <property type="entry name" value="MFS_SV2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000171">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511:SF5">
        <property type="entry name" value="MAJOR FACILITATOR-TYPE TRANSPORTER HXNZ-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511">
        <property type="entry name" value="SYNAPTIC VESICLE GLYCOPROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="109"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="137"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="238"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="349"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="390"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="416"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="442"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="504"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="69"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM36141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="531" mass="58090" checksum="F30DC74B580E4732" modified="2014-04-16" version="1">MDEIQVDKKQIRPTESSTPDYEVSKLTTIDDYEVEDFYGSSTTKAYRLKSELVGKCLEEIGMGWFQWKLFVVTGFGWIVDNFASQGIGSVQPPIKQEFTGIVQVSYSSVAYYVGLILGASFWGLSSDLIGRKPAFNCTLLIAGIFLCAAAGSMNFIAFSALWAVIGTAAGGNVPVDSMIFLEFVPGSHQYLLTALSAWWNLSQLIVSLISWVFLAHFSCPTDATPETCSRSQNMGWRYTLITLGGLALAFTIIRIFVFKLPETPRYLLSQGRDQDAVNAINYVAKQNGKPEPLTLEMLQEIDARFGNTPSEGESKRMSTKEIVKENMQAFRGEHYRALFATPKLGRQTLIIWAIWLTVGIAYPLFFAFLPSYLATKFTEKSSLSLTYRNYCITSAVGIVGPLSAAVSVNTRMGRRWMMSISAAVTGVFLFAYVGVNTPSADLAFSCVTSLLGNFEYAIMYAFTPESFPAPHRGTACGTAAALLRFGGLVASIISSQTGFTTAPIYASAALWIVVGVLCLGLPFETHGHDAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W6QJX9</accession>
    <name>W6QJX9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S05g000558</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QJX9"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM36725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="116" mass="12896" checksum="ECE8D02308EEDE60" modified="2014-04-16" version="1">MSASLKYADRQEMVDARNIPCGPHNRNRAQAGDGPGPGIPHGEKRTANTALLNANYRTFLERYTSLILLAKYHVIYAVWGHGANTYVRCLQFSEIREDHQSGKTRLGRWINGAGGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W6QK14</accession>
    <name>W6QK14_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S06g000124</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792020">
        <property type="protein sequence ID" value="CDM37163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QK14"/>
    <dbReference type="OMA" id="DMDREWK"/>
    <dbReference type="OrthoDB" id="5408734at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="108"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM37163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="139" mass="16010" checksum="D711792821480404" modified="2014-04-16" version="1">MFTETKEVESSNTMSDMDREWKPKVRPQSTMAQAFSTALDSAFMLDSDVDNLSQTISQKKQQMLIQTRELEELQNRIREAERRLQSQSTWSDHASSQTSQGQDQSAASQEGSNNEQQPEQSEPSEQFEESEQSEQRRNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W6QKQ1</accession>
    <name>W6QKQ1_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Phytanoyl-CoA dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PROQFM164_S02g000301</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PhyH family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QKQ1"/>
    <dbReference type="STRING" id="1365484.W6QKQ1"/>
    <dbReference type="OMA" id="ANIHIPR"/>
    <dbReference type="OrthoDB" id="445007at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20883:SF19">
        <property type="entry name" value="MULTIFUNCTIONAL DIOXYGENASE AUSE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20883">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE DOMAIN CONTAINING 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM30152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="286" mass="31291" checksum="AFEC75106BA68CAC" modified="2014-04-16" version="1">MRSPSLPRLPVSARPEAILDIYNDYGCVIIEGLLSSSEVASMNQEIDPGLAKLAPGKNGVPLEEFLGINTKRLPLAPNSRTFREVILENDLMHALSESILCDSPGEGYHINCAQVIEIGPGNAAQPLHRDQSVWPFWDLIPSPAPEACINFFCALTPFTEANGATRVAPKTHLDVDLNNLNPPQLLPVEINPGDGFLFSGRLVHGGGENRTNEYRRGITIHIARKGLMTEEAHPLSIPREIAETMSYRGQAMFGFRSNWPIKDGPVGTYWSSNFDEIGGHLGLKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W6QLI6</accession>
    <name>W6QLI6_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L27</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpl27a</name>
        <name evidence="5" type="ORF">PROQFM164_S03g001806</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL27 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM35079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QLI6"/>
    <dbReference type="STRING" id="1365484.W6QLI6"/>
    <dbReference type="OMA" id="NQWFFTK"/>
    <dbReference type="OrthoDB" id="2365484at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06090">
        <property type="entry name" value="KOW_RPL27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.770:FF:000001">
        <property type="entry name" value="60S ribosomal protein L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001141">
        <property type="entry name" value="Ribosomal_eL27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018262">
        <property type="entry name" value="Ribosomal_eL27_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041991">
        <property type="entry name" value="Ribosomal_eL27_KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038655">
        <property type="entry name" value="Ribosomal_eL27_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10497">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01777">
        <property type="entry name" value="Ribosomal_L27e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01107">
        <property type="entry name" value="RIBOSOMAL_L27E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDM35079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="135" mass="15570" checksum="E6029FB70430C5F1" modified="2014-04-16" version="1">MKFMKVGRVAIITRGRYAGKKVVIVQPVDAGSKSHPFSYAIVAGIERYPLKVTRGMGKKLVDRRSRIKPFIKVINYNHLMPTRYTLELEGLKGTITNDTFKEVSQREDAKKTIKKALEDRYTSGKNRWFFTALRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W6QLT5</accession>
    <name>W6QLT5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glycoside hydrolase, family 17</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PROQFM164_S05g000784</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell envelope</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 17 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QLT5"/>
    <dbReference type="STRING" id="1365484.W6QLT5"/>
    <dbReference type="OMA" id="KRTMITE"/>
    <dbReference type="OrthoDB" id="941679at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042973">
        <property type="term" value="F:glucan endo-1,3-beta-D-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050732">
        <property type="entry name" value="Beta-glucan_modifiers"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631:SF14">
        <property type="entry name" value="FAMILY 17 GLUCOSIDASE SCW10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004879937" evidence="5">
        <location>
            <begin position="20"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="68"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="68"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="98"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="117"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDM36951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="388" mass="42080" checksum="C157856C97AF528B" modified="2014-04-16" version="1">MKRLTQSLVGLLLACGVCAEAGADKQPRANLAQPAYTKEVVVWVNEKGETISTETHYVQALTSALQENQPSISTPDTNGAPPHALSKNSNDHPVPAKGKPKNLPHHPHKHPKPAVSHSHQNQHPNANFGISYSPYKADRTCKNQEEVNQDLDRISSYSFIRIYGTDCDQTKTVTTAARRHNMQVFAGIYDLTNFPSSLDAFSEAITDPNGKKDWSIFHTIAVGNELVNGGTNSATDVAAAVQTARSILRAQGYTGPVVTVDTFSVHLDHPELCHVSDYCAANCHAFFDATQQPAGAGAYALEQARSISAGAGGKRTMITESGWPHAGDANGGAVPSKENQLAAVESLRRSFEKRRGDLVLFTAFDDLWKDDNMYTFNAEKFWGIHGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W6QM82</accession>
    <name>W6QM82_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="9">TRAPP II complex, Trs120</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PROQFM164_S06g000507</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792020">
        <property type="protein sequence ID" value="CDM37545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1365484.W6QM82"/>
    <dbReference type="OMA" id="EHSRDRM"/>
    <dbReference type="OrthoDB" id="27962at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058565">
        <property type="entry name" value="Ig_TRAPPC9_Trs120_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058567">
        <property type="entry name" value="Ig_TRAPPC9_Trs120_3rd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058568">
        <property type="entry name" value="Ig_TRAPPC9_Trs120_4th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058564">
        <property type="entry name" value="TPR_TRAPPC9_Trs120"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013935">
        <property type="entry name" value="Trs120_TRAPPC9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058563">
        <property type="entry name" value="Trs120_TRAPPC9_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21512">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21512:SF5">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26254">
        <property type="entry name" value="Ig_TRAPPC9-Trs120_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26280">
        <property type="entry name" value="Ig_TRAPPC9-Trs120_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26282">
        <property type="entry name" value="Ig_TRAPPC9-Trs120_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26283">
        <property type="entry name" value="Ig_TRAPPC9-Trs120_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26251">
        <property type="entry name" value="TPR_TRAPPC9-Trs120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08626">
        <property type="entry name" value="TRAPPC9-Trs120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Trs120/TRAPPC9 N-terminal" evidence="4">
        <location>
            <begin position="5"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="Trs120/TRAPPC9 TPR region" evidence="5">
        <location>
            <begin position="414"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="domain" description="Trs120/TRAPPC9 first Ig-like" evidence="6">
        <location>
            <begin position="748"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="domain" description="Trs120/TRAPPC9 third Ig-like" evidence="7">
        <location>
            <begin position="1095"/>
            <end position="1297"/>
        </location>
    </feature>
    <feature type="domain" description="Trs120/TRAPPC9 fourth Ig-like" evidence="8">
        <location>
            <begin position="1303"/>
            <end position="1465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="201"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="215"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="232"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="278"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF26251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF26254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF26282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF26283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM37545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="1467" mass="161947" checksum="7C172C5357D4C465" modified="2014-04-16" version="1">MGVDPLSPIAPVRLRALLLPIGKIKRSRFLSFAARLQAENVVRLGDISPDARPNRNMFSPLAFPTGLILYDLSFSVPPTSHLELFPFELYREPLVIIAIADGSELPESTGDEQKHPTPEGLDRLLEELDGVKERNPRALLNQLVVFDHPGLDKITNGPDNVLWVPPPQTSKATTMKTVLCDITSVLLSEMDEFAKTIQSIPSIDSPKASSWGPHRNPELRPRPVDRLLNRMTLPTQISSNPHGTQDGTPLRSNASSPAPSDHETPTTFDEITRAIHLSSRTNSGSRAPSTASPKEHSRDRMSVSGMSATDRTKNRIKGRAGVIIGTLFLQAGRWPDALKELTEAANNARASSDYIWHAKALETILLCLLMFGWAGMDFQIPSVLYPVADKSSKPSRDSTTPSSAGNRVISLHNLANLLPDLSNTILNLYTRAANITDEPLPQLVFSETVIRLARLMVSARVRDGALDDNALKHIVMNEHLVPLLQLELPRGTVLLRKSEIANFLYRALPLALGADLPATDAVPIIVGVVAVLNFLDLPRKKAFILRELLSVMVPSLVQARKIGAAEVGIHPAAGLASLSDTAFDVNSLDAGPGNMESSVRLLLATIGEIYGVQPSSFYEWEKRQSQLSSASGLQESNEYDSVASIAERAFRHVVLDRYGDLNLKIDVLKACINCCEALPDFTGVLRFTVELLQTIRGDMMLGAAYRSPPYLPQDEQVRLLNNIKRTVGAGTRLGVSDMVAEYWDDFLVRDVKLLSLPDPKRPVRRSKTELDAVTTSSDKAKKDPFLYNPFAKPTSKALEMLTVADEPAPFQVTLQNPYEFEIEIEHLRLESSGVPFDAVAENFVIAPLSVQDITVLGVAHGEGSLQITGCIVKVRYCRTRRFPIFKTFWKPEPEVKFKRTGLGAKKPLTERPVSWSSTTSKDGKIDVKKGPETSTCEVKVIARQPSLVIESMSLSQSAMMVLEGEVKTFTITLQNASSCPVDFVLFTFQDSTTRQLQTALSNRDLLPVEIYELELKLATKPALRWRRLGQDPSDCSIAAGQKATFTVDVLGKPGLQETTVQIDYSYVGTGPGELPDIFYTRQLFVPLTVTVNASVEVARCDILPFSGDFAWKNHIEPSVDCIQKSDALLSTTDNEPFAQVLGRLGKGAYGPDHCIVLLDLRNAWPSPLSVWLRVSEQTMAALQPEATTTDDPEGKYSVDGDLQPGQVCRFVLVLPRVYLDNPHASIPVVNTGTRRQFVVSANKLSFEAEAASREAFWFREELLKRVLGGWKEPATGREGSIDLRNVRLNNRMVEAMRLEDVEMRFSLTSPSSSPDTSAAVEQTGRSRFHVKTDDLLTLNVTVHNRSSRPIHPILRLQPSLRHQPNNIALDLTRRLVWTGMLQQALPVLPCGESTNASIGVTVLCRGEYEFGASVEEARLIRPSFDDDGDIPADRYNDDGIMDTFGADVVRRRRIWHAKELCILNASD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W6QM95</accession>
    <name>W6QM95_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S06g000517</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792020">
        <property type="protein sequence ID" value="CDM37555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QM95"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM37555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="73" mass="8379" checksum="DA05341526B5A5CF" modified="2014-04-16" version="1">MQNELVRTSSSEETKVRTLKDGYWFLNRGSPCTVVANRTSCPKSWQKLSLVLKIIPVFLSCLLPSWTYLPWSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W6QMD8</accession>
    <name>W6QMD8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Chloride channel, voltage gated</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PROQFM164_S06g000091</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792020">
        <property type="protein sequence ID" value="CDM37131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QMD8"/>
    <dbReference type="STRING" id="1365484.W6QMD8"/>
    <dbReference type="OMA" id="CLDWTPW"/>
    <dbReference type="OrthoDB" id="44789at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005247">
        <property type="term" value="F:voltage-gated chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04591">
        <property type="entry name" value="CBS_pair_voltage-gated_CLC_euk_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03684">
        <property type="entry name" value="ClC_3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3080.10:FF:000011">
        <property type="entry name" value="Chloride channel protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.580.20:FF:000002">
        <property type="entry name" value="Chloride channel protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3080.10">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014743">
        <property type="entry name" value="Cl-channel_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001807">
        <property type="entry name" value="ClC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45711">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45711:SF6">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00654">
        <property type="entry name" value="Voltage_CLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00762">
        <property type="entry name" value="CLCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81340">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0868">Chloride</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="160"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="242"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="344"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="421"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="454"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="513"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="540"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="582"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="606"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="836"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="28"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="52"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDM37131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="861" mass="94030" checksum="18A0E4F127D89393" modified="2014-04-16" version="1">MSGQGSGGEGQSGTQLGSDQDILQPQEVNREAERLHEPISFKRKQKQRSRFSLSNLLSPPSGGSDTGFGSPAPQGGQNGDASPLDPYAPIGLNSGAEASKDGAPLDWYVEGPGRRVGYDDFTAIDWIYEYTKERQRKRLLYSSGQGLLGHARRLLDASNVWLVLIATGIAVGIIAASIDIATDWLGDLKSGYCKNGSGGGKFYLNKSFCCWGLDDQSKCLDWTPWGNALGAKSSGGAYTVGYVFYVSFSVFFAACACFLVRNYAVYARHSGIPEIKTILGGTVIRHFMGPWTLAIKSLGLCLSVASGLWLGKEGPLVHVACCCANILMKPFESLKGNEARKREVLSAAAAAGISVAFGAPIGGVLFSLEQLSYYFPDKTMWQSFVCAMVAAVTLQALNPFRTGKIVLYQVTYTRGWHRFEIIPFIILGIIGGLYGAFLIRLNTKVTKWRRARTSSRPIIEVVVVALITALINYPNHFMRAQNSELVQSLFAECNSVTYDRFGLCATGSASIGVAIYLVVAALLAFFLASLTFGLEIPAGIILPSVAIGALYGRALGIIVRLWQESYPQAFLFSRCEPDIPCVTPGLYAIIGAAAALGGATRMTLSIVVIMFELTGALTYVIPIMIAVMLSKWCGDIFGKRGIYESWIRLNEYPFLDHRDDTTPPDVSANRVMTTVDDISIITATGHTIASIRNLLANTTYRGFPIVSDTSSPVLLGYITRNEISFALKYSTSGTARNLSDETQVFFSHQPFADPSDTLDLRPWMDQTPMTLNSNITFLIVLKMFQRLGLRYVLFANKGILQGLLTKKDVWSVLNGVEIRREEALRDEEYQDFENRNEAEEVGLLDGNDTSSLGSSLRRDSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W6QNE9</accession>
    <name>W6QNE9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S12g000047</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792026">
        <property type="protein sequence ID" value="CDM38438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QNE9"/>
    <dbReference type="OMA" id="KHDKETH"/>
    <dbReference type="OrthoDB" id="4360605at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="221"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="71"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="48"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM38438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="245" mass="27717" checksum="460DDA099E5547C4" modified="2014-04-16" version="1">MAKTKPSQRKTGHRSDEGQYRATAPLCNSHRSAISGSKDDRNPLKHAIGLRKHPVSPITKRPRPKHDKETHRKCLRMVSSIEEEIQKAQEERDGERHKHCQLLEQLEAEKAEETSKLQLAITVRNEALADSQRVGQEICKLQQQLESTNTALQDLIPWNDIQLVLDQAHGDMVAMTTRFWNTIDALQNRRLASYLPGSGVIHADWPEQRGLTTESHEVHLGLSESNGPLPSHQEPFAANQDQSLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W6QNM6</accession>
    <name>W6QNM6_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type DNA-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PROQFM164_S14g000017</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792028">
        <property type="protein sequence ID" value="CDM38518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QNM6"/>
    <dbReference type="STRING" id="1365484.W6QNM6"/>
    <dbReference type="OMA" id="TWAIRVW"/>
    <dbReference type="OrthoDB" id="4220372at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053175">
        <property type="entry name" value="DHMBA_Reg_Transcription_Factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791:SF5">
        <property type="entry name" value="TRANSCRIPTION FACTOR DBAG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="14"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDM38518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="486" mass="54374" checksum="9C051A8C62FED7D5" modified="2014-04-16" version="1">MAPLNSFRPRASRSCGNCRAVKRRCDQQTPHCGQCIRMRQECPGYRDKWDLVFRDQTDQTIQRYRKPKIESPAQALPAPARSLSPNADDIGVNYFLRNFVSGQSSSRGCLNYIPSVYREDGEHPTLVASMAAVGLVALANSTQQSDLANLARAKYTEAIRNVNVALTSPVESVKDSTLMSVISLGVFEHVSEHKSWVRHVQGAAALVVARGKGQFTSTATILMFNQVRADLVLACVHNEEPFPKDMIQLQEEAAKHIDASGAFWLLGILGTRCADLLMGVRANTRQVPWPEYLEEATMMEREFQHTALLLATQEPYTVTQNACWAPKLSYNGRVDLYKDTWAIRVWNNLRNLQMIVYEIMLYLLNKILVTDLTLTSAVRQSLELKVQMAMQNLSMLGDDILATIPQALEFLSSASNTPSVDLSFRGSVSGGYILTWCLYMVGKCPATKAETRRWIIQRLQDFGRNMGISIALRLVDDIAKIDQFAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W6QNM7</accession>
    <name>W6QNM7_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein family UPF0248</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S08g000056</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792022">
        <property type="protein sequence ID" value="CDM38005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QNM7"/>
    <dbReference type="STRING" id="1365484.W6QNM7"/>
    <dbReference type="OMA" id="IVWDKRR"/>
    <dbReference type="OrthoDB" id="10263155at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040459">
        <property type="entry name" value="MJ1316"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04457">
        <property type="entry name" value="MJ1316"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MJ1316 RNA cyclic group end recognition" evidence="2">
        <location>
            <begin position="51"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM38005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="142" mass="16288" checksum="37DA580D08405A14" modified="2014-04-16" version="1">MASNNQSDTDADMITGQETSSFPAVSTSSPQKRDQRSVSPEYNPKAGENRLRPAGDIINRITWDSAFERSNYVIGFVDRFEGQLEVTMGSWKKETTDEEFIPQHRVLYIRHINGDIVWDRRRRIDKIFLSGNSAFNELAFLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W6QNX9</accession>
    <name>W6QNX9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="8">SMAD/FHA domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PROQFM164_S09g000036</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the Nibrin family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792023">
        <property type="protein sequence ID" value="CDM38120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QNX9"/>
    <dbReference type="STRING" id="1365484.W6QNX9"/>
    <dbReference type="OMA" id="GIGDHYW"/>
    <dbReference type="OrthoDB" id="552194at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030870">
        <property type="term" value="C:Mre11 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007095">
        <property type="term" value="P:mitotic G2 DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.20:FF:000082">
        <property type="entry name" value="DNA damage response protein RcaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10980">
        <property type="entry name" value="Nibrin, BRCT2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040227">
        <property type="entry name" value="Nibrin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032429">
        <property type="entry name" value="Nibrin_BRCT2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043014">
        <property type="entry name" value="Nibrin_BRCT2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12162:SF0">
        <property type="entry name" value="NIBRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12162">
        <property type="entry name" value="NIBRIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16508">
        <property type="entry name" value="NIBRIN_BRCT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="7">
        <location>
            <begin position="24"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="363"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="491"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="622"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="366"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="494"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="519"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="659"/>
            <end position="673"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00044757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM38120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="704" mass="79241" checksum="B26E4D03F13F836F" modified="2014-04-16" version="1">MWILDSTGDFLEGKRVWLRPGKRYLFGRFHRDGVRHAVNHNSISRKHMTIEISPVSPRDGLSLRARSNITITDLDSKKGTVVDERRIQGECKLEKSDEHLIQLAKYQHALRIKWEPVVLTLSSSSKQVRGEDPLAHVRSRLEDLDIKTIMDYIVDHTTHVVQRKRNTAKGLQALVNGKYIVDDSYIDALVYAATPGDLENIESLCPLETDFELAWPDPNQHLPPPGKEPTQRPAAAFAPNPARINVFEGYTFIFGDPSQFENLQGPINNGQGKALLYEIEDGVTTAADIVRFIKKAAGQKGVGPERHGSGGVVLVRFRSKGDLEQWSIDVGNEVALMMDQRVIEQREFLDAILGNDASPLCRTLPTEESSSQITASTPAVEAEQTSQQAVSAVPESVDLPNSEPSQPSKAPAKTRVRAYVSKMKTFDDGFDMQSVPVYAPEEEDTNINSTQTIDIETQAPSQEIQPLNIVKEEAEEDMVADLLPGARAMKRRRADMTRHHPEDEAVAPESEAPKRKRPKLDVLEAARKHREEEEQQRKAEEDSHSADVGDVDVDKLKNLAIVEEMEIPVRNAPAHEHDSSDRWDDQWNGRKNFKKFRRKGEPRSRARIQTVIVPLEEVTRKDYGIGDHYWGGNPAETYPQNEAGGPESDHHDEVAPSRSKLSAITRTSLQPTSDPTPARPPKRAREERDSDSDDELRFRFRRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W6QNY5</accession>
    <name>W6QNY5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S04</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S04g000670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QNY5"/>
    <dbReference type="OMA" id="HDEEPYD"/>
    <dbReference type="OrthoDB" id="4324085at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="431"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM35789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="545" mass="60290" checksum="05642E976DCFACBD" modified="2014-04-16" version="1">MDHHHPPTQVSDQVAAPSFLSGETDSMLSSYVALQSDLDEAYRKYLGYADIIGRGDLMAPLLGDSIFYPEVERTAARIFGEPRPRLVQGNVQAPIEWTDVLRESLTPGDFQRQENGMFLCRVRGSLIEVSEASYLEILTGVTERLLQPLQNLSDEQKETRARLKLGAYLHQTHESLVQFASAVRESIIALGVNPAIHDMQLSSIGFARARLPTPMSAPPVTPTQWVPYMSMSHTEGDIHESTIKEEETEFVRFETPGILGSYLAESRHPDSRGRVQSARSDVFRGNFIDSMSERNGYTPSSVDDLSSIDPASSSDYYASSIGITRSNSTDSASHRIAMDAYHSMVAASAYLNHNNYFNPELIDSNVLSVNNHAVENTDANVNSDVNARTEPSKLTSEMNVNSITPWLRDIDTSSDVGGDAESFGSNIPWLAQSEDASRPADTAAEQYGTRYRGVKRPRTECSSSESESKPGAGTRYSPREEADGPAFVKCLVDKGSTSDEIEEQYFKIFGVSRSAKCLCKKFEMRGTWGLLKSHREAKMQRTMSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>W6QQG9</accession>
    <name>W6QQG9_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Endonuclease III homolog</fullName>
            <ecNumber evidence="8">3.2.2.-</ecNumber>
            <ecNumber evidence="8">4.2.99.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Bifunctional DNA N-glycosylase/DNA-(apurinic or apyrimidinic site) lyase</fullName>
            <shortName evidence="8">DNA glycosylase/AP lyase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">NTH1</name>
        <name evidence="11" type="ORF">PROQFM164_S02g001908</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66592"/>
            <dbReference type="Rhea" id="RHEA-COMP:13180"/>
            <dbReference type="Rhea" id="RHEA-COMP:16897"/>
            <dbReference type="Rhea" id="RHEA-COMP:17067"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136412"/>
            <dbReference type="ChEBI" id="CHEBI:157695"/>
            <dbReference type="ChEBI" id="CHEBI:167181"/>
            <dbReference type="EC" id="4.2.99.18"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the Nth/MutY family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.-" evidence="8"/>
    <dbReference type="EC" id="4.2.99.18" evidence="8"/>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QQG9"/>
    <dbReference type="STRING" id="1365484.W6QQG9"/>
    <dbReference type="OMA" id="HEKWHEI"/>
    <dbReference type="OrthoDB" id="2099276at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140078">
        <property type="term" value="F:class I DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000703">
        <property type="term" value="F:oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006285">
        <property type="term" value="P:base-excision repair, AP site formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.30:FF:000014">
        <property type="entry name" value="Endonuclease III homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="entry name" value="Helix-hairpin-Helix base-excision DNA repair enzymes (C-terminal)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.30">
        <property type="entry name" value="Hypothetical protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03183">
        <property type="entry name" value="Endonuclease_III_Nth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004036">
        <property type="entry name" value="Endonuclease-III-like_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000445">
        <property type="entry name" value="HhH_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030841">
        <property type="entry name" value="NTH1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43286">
        <property type="entry name" value="ENDONUCLEASE III-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43286:SF1">
        <property type="entry name" value="ENDONUCLEASE III-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00633">
        <property type="entry name" value="HHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="DNA-glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01155">
        <property type="entry name" value="ENDONUCLEASE_III_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4 8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HhH-GPD" evidence="10">
        <location>
            <begin position="246"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="52"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="75"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="98"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDM31757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="469" mass="52009" checksum="A9415D14439AE4EF" modified="2014-04-16" version="1">MRTSRTSKDTAKVLQALSPPIRRQTRSCNVSALKSFAYNPNATPTVKIEPETVSVTPSWSAVKSEDESSLSELSDLSEADTADIEDLLEPPTKRQRRNASLITTRVLKQSASPGKLQKVIVKDEPDQKPTPARRPPARKTRDEDGSVKIEPPSNSETMYNIVKDEPDQKPTPAPKQRRLPARKTRDEDGSVKVEPPSNWETMYNIVKEMRANNPTAPVDTMGCSELYWRASSPRDRRFQTLIALMLSSQTKDTVTAVAMQRLHTELGDGSSPALDIKVKQENEDSKPTDSTLNLTNILAVDPTRLNELIRTVGFHNNKTKYIKATALILRDQYGGDIPSTPEGLMALPGVGPKMAYLCLSAAWGKHLGIGVDVHVHRITNLWGWNKTKTPEETRKALQSWLPHEKWHEINKLLVGLGQTVCLPVKRRCGDCDLAGLGLCKSEIRGLEPTVKKVKSSPAVDEPKVKIEAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W6QQJ1</accession>
    <name>W6QQJ1_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PROQFM164_S05g000172</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QQJ1"/>
    <dbReference type="OMA" id="WATVDIA"/>
    <dbReference type="OrthoDB" id="3897607at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF113">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="44"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="87"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="208"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="246"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="28"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="340"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="353"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM36339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="396" mass="44336" checksum="7C1A9D53F11B83C4" modified="2014-04-16" version="1">MTDEQQRKMACQTVAAVFLPIATITVALRIYVRGWIVKAFGWDDGVMVGAMLFYAMFCGTMIGGTIYGTGYMLDHLTVHNRVLAKKYWWLCEIAYCFASVGCKISVCIFLMRITIKPLHIWILYTVMLLTVLAGLVFMLLMLLQCRPLSYFWFQVARDASIHGKCMDMKVIVIMTYVYSAFAALCDFTVGLLPIFLVHNLQMKRQTKIAVMAILSMACIASSAVIVRMPFVNGFYDPDFLYATYQIAIWSNVEAGLGITAGSLATLRPLLRMWTGSHSDPYYNNNSGFPSAFPGGRSRSASRQLGGCDNRPFPLGSLDDSGHRLRPDKLAVTVTTIHSQRDPNDLYSTSPTSSEERLTSDRSSPRDIGLGIHRTFEVTQTSTERIDSERIAVREHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W6QR26</accession>
    <name>W6QR26_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7587 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S05g000357</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QR26"/>
    <dbReference type="OMA" id="DHYLCLW"/>
    <dbReference type="OrthoDB" id="3483554at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056009">
        <property type="entry name" value="DUF7587"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24494">
        <property type="entry name" value="DUF7587"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7587" evidence="2">
        <location>
            <begin position="45"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM36524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="296" mass="34283" checksum="0F2960098DED05A9" modified="2014-04-16" version="1">MQNIGFDKACAMELLQRTNPFLEERGLSKHSWAESPNAAYSGPLLRVWDKFSGSHPDQSGRMQARLPRERLGSQESRKEYLATHANYQIWEPTPFISFSASAPGLLRFLSRRKGPSFPRTLTAINPNVRIAYGLPMVEMESELKYYEVQDPYGRAYSYYKGEYLCLWEVTPDEVVAHWDWDVLIENDHWYEDEILPAFKEHNDLFLRRSRIKATFDMSTLESALPRMLPGSVDRDALSGSDLDHSSQLDPLSNEDWNSSSEEENWQFEDDAYWDTDDEAEEANAIDDAYKILEGDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W6QSW8</accession>
    <name>W6QSW8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S06g000155</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792020">
        <property type="protein sequence ID" value="CDM37194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QSW8"/>
    <dbReference type="STRING" id="1365484.W6QSW8"/>
    <dbReference type="OrthoDB" id="10472433at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM37194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="358" mass="41559" checksum="0A3EE8BF7906C89D" modified="2014-04-16" version="1">MSSKLPPRRTRADHNAEEWWALLEIPKTEKEWEDAASNPYIPPTSAKSETEKSKGKEPAKTTDKPQKAPDPRHGKRIRDLHVREMKGCLSASKIGLPEYLTGRIIWHKAKISDLSIDENQSKPLTDVQKGLGFEKAAREFAAKYQTKNTEFKRYYKHIKKYGSSLRDDERRCTGEYAFDLRDVGEVAMQKESRFFLRPQSEQGDMDMDRNDQESDRPAKKQKKSDEDGRLILYADGQLVNPQNRNDIHCIVEVKSNLLRSKTGYENFLRQMGWEMLFWIANCHKLNLMKKPVYLVIARFEQPWLDYISGEDPEDNQPGDSFLHLYLAGPLSVYNHKHVKLFGKFVVTFTKQQLLDIPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W6QTD0</accession>
    <name>W6QTD0_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Probable transposable element</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S02g002918</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QTD0"/>
    <dbReference type="OMA" id="HRTPTEN"/>
    <dbReference type="OrthoDB" id="4362013at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="119"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="82"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="135"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="163"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM32767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="498" mass="56531" checksum="642663953B97043D" modified="2014-04-16" version="1">MADPPAGGPEPPPTNTQETQASFSVEDFQPRVSIDAGQIIGKRTRNGEAYTPAEGTGRITTREVWKLIDNLKDIIHRQTTLIESTKADLEEVKHDQNVLREQNDRLHEEVRALRAQIETSPQPNPPRTWAAIAASGTSDPQPSLQRPEKDRNCVRISTQRLSVDPRDNESREGNSFGRYLSTDSANPYIRSALLSAPPTQDAQVAGIGTTKTGYLVRFKDPGSAEAARNNTEWLNELGKNTKLVKPRFGVVVHRTPTENFDLENANSQAIQTIMEENDLAEQGFQIEELAWLKRKDKVLGKFASLGIWFDSAEGAEYILNNGLLVGQRYIGSVERREIKKKRCFRCQRFGHLAWSYKETPRCGHCAGQHERERCPPGVRARVPNTIDLQPYQMLEKYLRILQLNMMKSGPRMEALINDPQSRELDVLLIQEPSITTYRTHINHSAWHLSRPTTQTDAVRFRSLLYVNRRISTSSHRQLPYDHPDVAAVKIWTADSQRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W6QUU5</accession>
    <name>W6QUU5_PENRF</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S07g000248</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
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            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792021">
        <property type="protein sequence ID" value="CDM37899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QUU5"/>
    <dbReference type="STRING" id="1365484.W6QUU5"/>
    <dbReference type="OMA" id="IASHNLY"/>
    <dbReference type="OrthoDB" id="5352400at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="14"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="271"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="293"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="310"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM37899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="321" mass="35620" checksum="BCD5B9960EB1A338" modified="2014-04-16" version="1">MQFLFPKKHKHHKLVLWLMTGEFPITIVMLTLTGIASHNLYQTLLWQDGADNGFNSAPNEALYAAANYTPFKAPMVWSSFITSYNLVLAVLSTFFLITKLPTHWMNLFYPPVAVAVHVSLVALYIVSAVYQAGSDMSAPRHPQPGAPWYIAKSCSVAYKKSNIGYCMQAKALFAVTVIMVVYYVIILGFCIHSCFITPEERDAILEQREERRIEKEFEEEIIKSPSMIPMTPGPMPRSGMVPRTPGVPPMAVGGNISPFAPRTLAFNRLGNGSTASDLPLRDNSRMPQPQYPSPQSYEVSPESSAGSPMYFPPPPKKAARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W6QVG7</accession>
    <name>W6QVG7_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S03</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S03g000281</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QVG7"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM33557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="55" mass="5574" checksum="6E6B291245C38FD1" modified="2014-04-16" version="1">MVGSPVYLAATSFVPGLGITSVVLSAILGSYKNANRMNGCSNNSVALCIAIIRTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W6QWL6</accession>
    <name>W6QWL6_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S15g000018</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792029">
        <property type="protein sequence ID" value="CDM38554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QWL6"/>
    <dbReference type="OMA" id="GYESECF"/>
    <dbReference type="OrthoDB" id="4349275at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM38554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="188" mass="20975" checksum="266010E3B2275ABD" modified="2014-04-16" version="1">MKMDESDRDAYDLDLDLHAVWLESSGIPTPPPCLATDPGDPRPTSSNRGEPAGCSNQRSSMIECLFHPSLDDLSGFKWTGPDPLSISTQAGDIFLHMSAFLFPKEIHWIELRLARFDGISDEILGEHLFFLPRVETVLGNLGFRLSLWPRLEPLPYSSHLKLSSLAALPPTLSLDPRFFVHNISGSYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W6QWR2</accession>
    <name>W6QWR2_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein kinase-like domain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S29g000001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792043">
        <property type="protein sequence ID" value="CDM38595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QWR2"/>
    <dbReference type="STRING" id="1365484.W6QWR2"/>
    <dbReference type="OrthoDB" id="2156052at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM38595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="159" mass="18337" checksum="2FE1A2560FC7C4FC" modified="2014-04-16" version="1">MAQMMILSCFFHWERDKALAVLRSHRVVHSDKDVKWLKCPRTLEPTSGNMQYGHRVGAGKSKQRLLFSSTAEIQRPNKAIKALGVIHEDLRRVNVLWNEKLGRALISDFHHSRLKCPPAPKRSRSKRQRLQTESEDAKRLRDTTAYSPEAHKSGIRFGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2024-10-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>W6QXK2</accession>
    <name>W6QXK2_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S03</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S03g000981</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QXK2"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM34257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="56" mass="6167" checksum="3D5213822297EAF7" modified="2014-04-16" version="1">MSQLPRTNLLCANLRDYWSGEGGSQLRLVSFLAEDPDPKQHEGPCASVYGLVTLMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W6QYB9</accession>
    <name>W6QYB9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Histidine phosphatase superfamily, clade-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S03g001271</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QYB9"/>
    <dbReference type="OMA" id="HDKITHL"/>
    <dbReference type="OrthoDB" id="496981at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050275">
        <property type="entry name" value="PGM_Phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100">
        <property type="entry name" value="BROAD-SPECIFICITY PHOSPHATASE YOR283W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100:SF54">
        <property type="entry name" value="PHOSPHATASE SPAC5H10.03-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM34547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="274" mass="30774" checksum="E4C26FBD12ACAC23" modified="2014-04-16" version="1">MAPIIHCVRHAQGLHNVCTANHIIQDPVLTELGHEQCRKLRESFPRHANIDLVTASPLRRTIYTALESFAPVFESKPDLKIIALPDIQETSDVPCDTGSDPSVLKEEFKTGVDLDLVQDGWNNKASGRYAPTNKALKERARAARRWLKARPEKEIVMVTHGGFLHYFTEDWEDSSQFQGTGWSNTEYRTFAFSGEAHTDDLEGYPLDGDNASLEETLESRQRRGKTGPMPSREEQKTLYKKGYQGWDDQGLQMSTADREAAKATGGEEVNGVRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W6QZ44</accession>
    <name>W6QZ44_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pectin lyase fold/virulence factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S03g001529</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1365484.W6QZ44"/>
    <dbReference type="OMA" id="NIEFYMS"/>
    <dbReference type="OrthoDB" id="1046782at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23668">
        <property type="entry name" value="GH55_beta13glucanase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000049">
        <property type="entry name" value="Putative exo-beta-1,3-glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039279">
        <property type="entry name" value="QRT3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024535">
        <property type="entry name" value="RHGA/B-epi-like_pectate_lyase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33928:SF2">
        <property type="entry name" value="PECTATE LYASE SUPERFAMILY PROTEIN DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33928">
        <property type="entry name" value="POLYGALACTURONASE QRT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12708">
        <property type="entry name" value="Pect-lyase_RHGA_epim"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004880247" evidence="2">
        <location>
            <begin position="23"/>
            <end position="1407"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="3">
        <location>
            <begin position="1186"/>
            <end position="1231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM34802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="1407" mass="153596" checksum="FD36B2C5B1C4CBFE" modified="2014-04-16" version="1">MAGVIFVLRWLLLICQITGIWAIHAHHSHEHLHQHFNRQNVASVSVTVSSSSAAASSSSQFGNSDAATKVSEALRALAVVNKLRVDNVKFNRYSMANAKDVTGERINAPPLDYSRGAVTRLSALQNASESELSKEKRQESTNTNDSFAYTIPKDLADAARALAESVRPTASTGEEEALAAKVHAKYRSKTNDTNRPPQRLQHPNGLFGYVADEQTVLQSSDLQSENSTLVKRAASGSDYWLANLQQNAASPFAPSGYKVWRNVKDYGAKGDGVTDDTAAINKAISSGNRCGANCGSSTIFPAILFFPPGTYLVSSPIIQYYNTQFLGDPTNYPTILAAASFVGLGVITSDVYVGDQEQWYLNTNNFLRNVRNFKMDITRTDPGAYVCAIHWQVAQGTTLENIEFYMSQATGNTQQGIYMENGSGGFMSNLTFVGGNFGAYLGNQQFTTSQLVFVNCKTAVQVHWDWAWTMQDVVIESCGSGIVVTGGAGGLESTGQAVGSYILVDAIIANTPTGIRTSLYADNSTAVLLQNVGFFNVKDAIVADTRTEPLLAGGNEVLVPSWGFGLYHDDTGLHFAQQEQLQVLNRKSILTSDKSYVKGTANFFARRRPQYLDLGGGQVFDVKAYGAKGDGVTDDTAALNSVLSAAANMSSIVHFPYGVYVIKDTLHVPLGSRIIGQVWPQIMATGSKFEDAENPHVAVQVGKEGDTGILEIQNMMFTVSGPTAGAVLMEWNVHESTQGSAGLWDCHFRVGGAIGSKLQSDKCSKKASSLNKDCIAASLLLHVTKSASAYIENLWAWVADHDLDKVTQDQVDIYVARGILVESQGPTWMYGTASEHSVFYQYQFSGAKNLVMGMIQTESPYFQPTPPMPKPFELGKFPNDPDSNECKTCTSSWAVRMINSESIYMLGAGIYSWFNSYSQDCLETNNCQEKAFYVEQSSDIWIVNLVTKAIVQSISPLGETAIFAKDARNGYLSSLLGWFRKAKDIVGQRKFTGFYFYDKTYQQEFLSQLSPICQTAITRLIDCDDEVYMFQKPRWRQGFDNDTLSDLVCSSSCGQSIETWFHQVTTNCGSNEETGAPFNMKGGATWAGWNETCAKDATSGKYCGDVINGFNPDLDSMPTAELCSSCHVGRYRMMQSTPYSAYDINFQSQLKYINSKCNLNIPTDIPDPLQPTIDPYKPADSCVSGIKYTTVAGDTCDSIATKYKVSSAALFIGHDNLFECKDIQVGTKLCMPIQCETVYTIKGEDSCTSIEKAQGVGYKDGTTLRKYNPWINYDCSNLHIVSDVAYGHVICLTPQSGASNATAPPYDPTSPGSADGYVIPQIEPPKNSTVAEGTTTRCGKWHVVTNEALQETCTTICIQSKIPWGLFLDVNPSLGPDKCSDQLVAGNAYCVGPTYSWDEFFDDADTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2024-10-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>W6R0L3</accession>
    <name>W6R0L3_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S04</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S04g000248</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6R0L3"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM35367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="38" mass="4416" checksum="32089462A7D90F60" modified="2014-04-16" version="1">MERIPYRFPRHGESIVEQIFVAHPGPQALLGNSDHLFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W6R1B0</accession>
    <name>W6R1B0_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Homeodomain-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S04g000498</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6R1B0"/>
    <dbReference type="STRING" id="1365484.W6R1B0"/>
    <dbReference type="OMA" id="GYPPRTI"/>
    <dbReference type="OrthoDB" id="2350934at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053095">
        <property type="entry name" value="Actin-binding/GATA_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23246:SF24">
        <property type="entry name" value="MYB DNA-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23246">
        <property type="entry name" value="NEW-GLUE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH myb-type" evidence="3">
        <location>
            <begin position="85"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="2">
        <location>
            <begin position="85"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="260"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="55"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="204"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM35617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="291" mass="31999" checksum="EE5B112C7E566143" modified="2014-04-16" version="1">MIALQNRPILPPVKVDISLLLKPQDEEEAAPGLNTGYPPRTIGPPLGLGPMMTMPGPAAMVMPPLTKSGPSGAAKRLQPSHTSESPAKKQSKWSPDEDALIIELRGSGMKWEDISKRLPGRSAISCRLHYQNYLERRSEWDEDKKNKLARLYERFKAEMWSKVAEEMAIPWRAAEAMHWQLGEQEMARRAGVVPFSLSSAAIDPPTTRTRRASTSLSRPRKGSSSRAIPGHLPGLPPQLPSLEELTAGVPAYAPAPPPPREFYGIGRPPEMGIPPPNFMGHHLGMPPRTMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W6R2G8</accession>
    <name>W6R2G8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Protein transport protein SEC61 subunit alpha</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">sec-61</name>
        <name evidence="14" type="ORF">PROQFM164_S04g000918</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the SecY/SEC61-alpha family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM36037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6R2G8"/>
    <dbReference type="STRING" id="1365484.W6R2G8"/>
    <dbReference type="OMA" id="PMMRQMF"/>
    <dbReference type="OrthoDB" id="420669at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3370.10:FF:000002">
        <property type="entry name" value="Transport Sec61 subunit alpha isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3370.10">
        <property type="entry name" value="SecY subunit domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002208">
        <property type="entry name" value="SecY/SEC61-alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030659">
        <property type="entry name" value="SecY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023201">
        <property type="entry name" value="SecY_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019561">
        <property type="entry name" value="Translocon_Sec61/SecY_plug_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00967">
        <property type="entry name" value="3a0501s007"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006341">
        <property type="entry name" value="PRK08568.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10906">
        <property type="entry name" value="SECY/SEC61-ALPHA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10559">
        <property type="entry name" value="Plug_translocon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00344">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004557">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103491">
        <property type="entry name" value="Preprotein translocase SecY subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00755">
        <property type="entry name" value="SECY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00756">
        <property type="entry name" value="SECY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 10 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="75"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="145"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="244"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="284"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="359"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="416"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="440"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="Translocon Sec61/SecY plug" evidence="13">
        <location>
            <begin position="42"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF10559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDM36037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="478" mass="52206" checksum="B32A7BBC4B389D7B" modified="2014-04-16" version="1">MSGLRFLDLIKPFTPLLPEVAAPETKVPFNQKLMWTGLTLMIFLVMSQMPLYGIVSSDTSDPLYWLRMMLASNRGTLMELGITPIISSGMVFQLLAGTHLIDVNLDLKTDRELYQTAQKLFAIILSFGQACVYVLTGLYGQPSDLGAGICVLLIVQLVVAGLVVILLDELLQKGYGLGSGISLFIATNICESIVWKAFSPTTINTGRGPEFEGAIIALFHLLLTWPDKQRALYEAFYRQNLPNVMNLLATLLVFAAVIYLQGFRVEIPVKSSRQRGMRGSYPVRLFYTSNMPIMLQSALCSNIFLISQMLYSRFSENILVQLLGVWEPREGSAQLYAASGIAYYMSPPLNFKEALLDPIHTAVYITFMLVACALFSKTWIEVSGSAPRDVAKQLKDQGLVMSGHREQSMYKELKRVIPTAAAFGGACIGGLSVASDLMGALGSGTGILLAVTIIYGYFEIAAREGDIGAGLKGLVPGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W6R3K4</accession>
    <name>W6R3K4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S05g000215</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6R3K4"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM36382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="59" mass="6780" checksum="D17C9A8AAAE4E2AC" modified="2014-04-16" version="1">MNFPRRPDHLNISQSRQSIIISYRTRPTQEAGNRKQGVSGDISLLSRIVHHCPSLRPRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>W6R505</accession>
    <name>W6R505_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Ubiquitin interacting motif</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PROQFM164_S05g000740</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the epsin family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1365484.W6R505"/>
    <dbReference type="OMA" id="STEFYDI"/>
    <dbReference type="OrthoDB" id="4033880at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030125">
        <property type="term" value="C:clathrin vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:K63-linked polyubiquitin modification-dependent protein binding"/>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000147">
        <property type="term" value="P:actin cortical patch assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="ENTH_Ent1_Ent2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EH domain binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013182">
        <property type="entry name" value="DUF1720"/>
    </dbReference>
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        <property type="entry name" value="ENTH"/>
    </dbReference>
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        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12276:SF110">
        <property type="entry name" value="EPSIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12276">
        <property type="entry name" value="EPSIN/ENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08226">
        <property type="entry name" value="DUF1720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01417">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00273">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00726">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="10" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="ENTH" evidence="13">
        <location>
            <begin position="10"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="155"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="285"/>
            <end position="325"/>
        </location>
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            <end position="412"/>
        </location>
    </feature>
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        <location>
            <begin position="451"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="540"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="183"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="222"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="356"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="374"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="540"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="551"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00010130"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022499"/>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
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            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50942"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CDM36907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="576" mass="64191" checksum="3637F160FFF0CF9A" modified="2014-04-16" version="1">MSKVVRSVKNVTKGYSSVQVKVRNATSNDPWGPTGTEMSEIAAMTFGSPNEFYEIMDMLDKRLNDKGKNWRHVLKSLKVLDYCLHEGSELVVTWARKNVYIIKTLREFTYVDEEARDVGQNVRVAAKELTALVLDEDRLRSERSDRKLWKTRVSGLDEGYGNSPVEPPRRERRRRNGDDDSDIEYHLAIEASKAEAEDERRRRAKETMAGQDDEALAKAIKLSREEEDLRKRELEESNAQSLFDDTPAPAQVQPTGYNQGYQQQGAVDWFGNPINAQQPLSTGYLNNQYAQPTGFQNQPTGMNNPYANGYQTQPSAFDQNPYGQQQNNLLQPQATLQPQHTAFNPNNPYGADVFSQQQQQQQQQQQQQQQQPQENYQTAGSNNPWAGSHSQQLQPADALKPMPTGSNNPFAQRTQTQFNNHAKTGPPTLNSLSEDRATNQFAQNNSQYGQSSLFAQPSQPNPIAGFQAPQPPKSTSPLNPHHARLNALLGSGEGQDTFGNVGDLRIPAQHTTPGTFVNSAGLGLDRLHAAPTGNPFFGQQFTGMPQQTGFQQQPANNNPWAGQQQQQRGGGSLIDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W6R8A7</accession>
    <name>W6R8A7_PENRF</name>
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        <recommendedName>
            <fullName evidence="3">Methyltransferase type 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S09g000018</name>
    </gene>
    <organism evidence="1 2">
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        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
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    <dbReference type="Pfam" id="PF13489">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM38102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="297" mass="33263" checksum="3DFBF4461CABEEAA" modified="2014-04-16" version="1">MTDSSQAQAVDKNVEEVGSRYFLPRNLEEAERMQNQHEWLKGGANGLILAPIDLNRSGLRVLDAATADGYWMQDVKSIFPKDAEFVGFDNASQSVPRSPEGYPPLKDSSQFQIVKQNLVEEFPAEWKDSFDLVHQRFVIPLFKTEEVPLVLRNLIRCVKPGGWIQLVEMDFQTPVSKPIESCPAVQAVHKLTSTVVSDPLASTKLAGRLNDEGLVNVGYKAIEMVAGSSNSDPELGARGKRNMLSVLGFFQSVAKPEMIGMTEEEWKTLPERFAKEMDEHHVALNVYFVWGQKPEAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W6PRN9</accession>
    <name>W6PRN9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PSP1, C-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S01g000344</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PRN9"/>
    <dbReference type="STRING" id="1365484.W6PRN9"/>
    <dbReference type="OMA" id="GIWNTES"/>
    <dbReference type="OrthoDB" id="243127at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047767">
        <property type="entry name" value="PSP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007557">
        <property type="entry name" value="PSP1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43830">
        <property type="entry name" value="PROTEIN PSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43830:SF3">
        <property type="entry name" value="PROTEIN PSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04468">
        <property type="entry name" value="PSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51411">
        <property type="entry name" value="PSP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PSP1 C-terminal" evidence="2">
        <location>
            <begin position="615"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="420"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="584"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="730"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="83"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="425"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="584"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="763"/>
            <end position="774"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM26535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="832" mass="90331" checksum="32A60F5235DB5BD4" modified="2014-04-16" version="1">MAQSSPPATATASAILEKTHPGVRRSTPDSDALASSDDDGDHGAQAQNFIPPTTRPPVRRTSWLNEVPLSAQRKHSLPGSHLSSAPSNPTSPATDQASWATATSPNLAGSFNWNQPGGSTLPWGTSTGIWNTESRREPPSRLAEMIPSPTMTNPPPSGGTIPDEMLSPITRTISGDSAIPFSIPLQPTLKTYRSQSYSVGQMDPEFLSLAAGKAGAGAQYPGSRSRAPGQMSAVQPRASRPSMLGELGHDTAMLGRVREDDDDDGDESFNGSESEMSYSASQARQIEQLARENALLRQAAAAGQMDNRYRERAGSVASSSGGGHPLHRIRGGVPEGDLAAEDLGELRDITGYNMRGNARRRFSEHLAPPEAQFSSFTSPLENRALDNVRKAHWQTSLGFGGMSDMPQSRRHSFAEIPMRHGSVGSVDSHSTATPRATIGDRDDGYSNLGDYPNQPYYSREQTLRGDGSSGIPSSLNQYAMSNAYGRQSSALSHAHQNQLLYIVAFKCSRADVFYIQEDTGLQVKTGDLVIVEADRGTDLGTVIHANISLQQARELKQHYAEEHYKTLMIFSRHGQPEGSTLANPNTGLNTRSATGGMGPHGPHSVQEPATDIKPKLIKRLAQQHEVLTLHDKEGNEAKAKRVCQQKVVEHRLNMEILDAEFQMDWKKLTFYYFADSYINFNSLVTDLFKIYKTRIWMSAINPASFVTPPTSGLSGPGTIPNPLYAQEADRRHQLDSRSYGGARDSVDTGRDMPNPVGMLRTSYGESYQPFSQPSRHSEGLNSDAFAPHVPSSFGPADSFEYPGNIGSSNGSSRVHPAQGEWINRFQGLSLNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W6PRR9</accession>
    <name>W6PRR9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="6">60S ribosomal protein L20</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rpl20b</name>
        <name evidence="6" type="ORF">PROQFM164_S01g000260</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL20 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PRR9"/>
    <dbReference type="STRING" id="1365484.W6PRR9"/>
    <dbReference type="OMA" id="CIFAKND"/>
    <dbReference type="OrthoDB" id="1294322at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.10:FF:000001">
        <property type="entry name" value="60S ribosomal protein L18a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L18a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00273">
        <property type="entry name" value="Ribosomal_eL20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028877">
        <property type="entry name" value="Ribosomal_eL20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023573">
        <property type="entry name" value="Ribosomal_eL20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021138">
        <property type="entry name" value="Ribosomal_eL20_eukaryotes"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10052">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L18A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01775">
        <property type="entry name" value="Ribosomal_L18A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160374">
        <property type="entry name" value="RplX-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein eL20" evidence="5">
        <location>
            <begin position="56"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDM26451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="225" mass="26183" checksum="55A2340B5157E95F" modified="2014-04-16" version="1">MWGRRGNVAGAMWRKRSGAGKGGNPKHNWNLTILIFHRRHTNDSSTTATITVRRLTEYQVIGRHLPNEANPTPKLYRMRIFAPNTVVAKSRFWYFMSQLRKLKKANGEIVSLNVIDEKRPLKVKNFGIWIRYDSRSGTHNMYKEFREMSRTDAVEALYQDMAARHRSRFGSIHILKVVEIENNDSIRRPYIKQLLQKDLKFPLPHRAGGKVGKKVFAYSRPSTFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W6PRT9</accession>
    <name>W6PRT9_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PROQFM164_S01g000394</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PRT9"/>
    <dbReference type="STRING" id="1365484.W6PRT9"/>
    <dbReference type="OMA" id="HEIDGCA"/>
    <dbReference type="OrthoDB" id="1405469at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000306">
        <property type="entry name" value="IKS protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000699">
        <property type="entry name" value="Probable serine/threonine-protein kinase iksA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050339">
        <property type="entry name" value="CC_SR_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE EIF2-ALPHA KINASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042:SF138">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE IKS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="669"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="153"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="116"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="265"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="478"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="89"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="527"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="537"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="563"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="582"/>
            <end position="595"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDM26585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="715" mass="79468" checksum="BC91B6F3E87E21B8" modified="2014-04-16" version="1">MPADMSMIPYNGGNLDVVLRHNDSVVVFDHDSQQLVLRNTSDEDIDHLELANCPFCHRSMRENSRERHCGDTEPEGEFINPNYFHMLNNSLPSSATSSTPPSPRHRLVQPALPRRPINNASVQPTSSPQPPPQPSPQGISSAAFSPDYFKRFFVEERVLGKGGKGVVLLVKHVLDSVSLGHYACKRVPVGDDHEWLEKVLGEVQLLQHLSHQNLVSYRHVWLENAKISTFGPSVPCAFILQQYCNAGDLHDYICGSVQTSTTAQQLKDRLRRKSKGEPDPRSKLGGARTLQLDEIYSFFRDITSGLRYLHANGYIHRDLKPNNCLLHETGDGIRVLVSDFGEVQSQNAMRMSTGATGTLSYCAPEVLRQEYPGGPFGNFTFKSDIFSLGMILYFLCFAALPYANADLINEEKEDLDQLRAEITSWAGFDHARAIRSDLPEKLYKFLERLLSVDPSRRPSADEVLNGIQVGANSNENFRFRKASSGSSDLPGAARIRPLDSQQPSVERALSPTKSLHRNPASFRGDSMSDSSHFRSSTAPVSDTNADGPSASPDQDMIIRHRYSTSPTSSPVHSPHESSSPLDPQPQPPLPQHHLLPPPPSRFPFLNYLTSLNPLLSSPVLQLTLFLVKIISLLHPCSPLAVNPWILYPLLLSAAFTLRARSIQTQTLAVFLHLLVVGLGFRLGALCIWRRNSDITFTFNVHLHDTPPTVPLLSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>W6PT06</accession>
    <name>W6PT06_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S01g001122</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PT06"/>
    <dbReference type="OrthoDB" id="10458544at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM27313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="73" mass="8016" checksum="C452897AF5CB7B0E" modified="2014-04-16" version="1">MLFPGSGSHQASPITRPARSSLLYTDFESTALFRLSAEKKNPSPRQIPSTDLALPVNFFTHYYIGAYGVPVTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W6PT96</accession>
    <name>W6PT96_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Heat shock protein DnaJ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S01g000914</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PT96"/>
    <dbReference type="STRING" id="1365484.W6PT96"/>
    <dbReference type="OMA" id="CHRWMPI"/>
    <dbReference type="OrthoDB" id="442087at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43948">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43948:SF10">
        <property type="entry name" value="MRJ, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="9"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM27105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="477" mass="54210" checksum="CF1FAF019906350D" modified="2014-04-16" version="1">MSTATVIVDAYAILGVERHAKLPDINIAYKRLALKLHPDKAGNSATTIERFRKIQDAVEILRDEDRRRLLDEALQKKAKRHLAPEDETPTWAYKGNYNRPPKRERHGYESNWPSQCSEPASKHKPRDRRQHSHTYYYSYGTSVHMDPESAESKARRAQFEAENVQWENEWAGIDPEVQKARAELRRENMRARMKRDLADMAKDHDGDTKFADTVDNVIEGALDDLEFGYEHNLVHLLPEKNIKTCNPADTFDTFAYEYSRKLRSYDEYPIHSDCASVANNDSPFGLSTSSNSSNFTDSPFGFSTISNSTSFTDSPNKHSNFKATVEDFESPTDDPESATDDSNFDVDKLINSYMVGHDSLLPLISFLEQKLADPHGRYTPNDLAGELNGLMLEIYCGWLEEVRLSVPNASPITIGNDPSFCSHLGLWYKDFCRPMCSDCNLWMPSFTLTCPGCGIKACVRCKFTSYGFLLESVTQEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W6PTI8</accession>
    <name>W6PTI8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Pre-mRNA-splicing factor cwc15</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">cwc15</name>
        <name evidence="6" type="ORF">PROQFM164_S01g000890</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in pre-mRNA splicing.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CWC15 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PTI8"/>
    <dbReference type="STRING" id="1365484.W6PTI8"/>
    <dbReference type="OMA" id="KYREHGQ"/>
    <dbReference type="OrthoDB" id="30179at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006973">
        <property type="entry name" value="Cwf_Cwc_15"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12718">
        <property type="entry name" value="CELL CYCLE CONTROL PROTEIN CWF15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12718:SF2">
        <property type="entry name" value="SPLICEOSOME-ASSOCIATED PROTEIN CWC15 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04889">
        <property type="entry name" value="Cwf_Cwc_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="69"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="97"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="144"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDM27081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="237" mass="27064" checksum="C840506DC58CC0F3" modified="2014-04-16" version="1">MTTAHRPTFDPAQGKEALRGPAYHQRLLPAHKHLKVRQPGQGGAADADPSPRDLRAELLQAEAAHFAKKNGVPVDQPAIAESSVPKRLLEAAPQDGSEGDIQEEDPEAKRRRILEETRDIDADSDGSEEDSSDEDSDDEDEAAELMRELEKIKRERLEQKEKEERERAAEEEEQREVDIARGNPLLNSQDFNMKRRWDDDVVFKNQARGTENRDGKEFVNDLLRSDFHKRFMGKYVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W6PTN2</accession>
    <name>W6PTN2_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Zinc finger C2H2-type/integrase DNA-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S01g000940</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PTN2"/>
    <dbReference type="STRING" id="1365484.W6PTN2"/>
    <dbReference type="OMA" id="HSSFWRG"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051061">
        <property type="entry name" value="Zinc_finger_trans_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179:SF19">
        <property type="entry name" value="C2H2 FINGER DOMAIN TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="319"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="350"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="384"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="240"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="206"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM27131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="442" mass="48152" checksum="50BF37EF9829496B" modified="2014-04-16" version="1">MKPNYGESETLPPFVSASEKEADAEGSPPHHPEIAAAARISPLEPLPGNLKNHKQPPDFDPRDSKRLNSSAKEGQSKPELKAAPGPVSGSASHKSKPPRRRSLPFKPIQPDNKVKDEFVPRERLQSLSGSVQRPQQVLPHLKTPPEREPQIPLPSLKLIQSSSGSCLAKSPDSNKQTLPSIHKALSALSDFGAPTVNTMSSPFPFSSCPGSSTSGNDSPFDRTFPGKFSIPASPFSHFSPVSMKDSPTNPSPASHSSFWRGPPHSEMLSVQTPYDASPMTAQNPATSYPTPTEQVGASMGDRHSLAASTPQANGPLGSYRCTHSGCTAAPFQTQYLLNSHANVHSQDRPHFCPVEGCPRALGGKGFKRKNEMMRHGLVHNSPGYVCPFCPDQQHKYPRPDNLQRHVRVHHVDKNKDDPILRQVLAQRPLGSTRGRKRRMNNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W6PU89</accession>
    <name>W6PU89_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="23">Folic acid synthesis protein FOL1</fullName>
            <ecNumber evidence="10">2.5.1.15</ecNumber>
            <ecNumber evidence="12">2.7.6.3</ecNumber>
            <ecNumber evidence="11">4.1.2.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="24">Folic acid synthesis protein fol1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="26" type="ORF">PROQFM164_S01g001564</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="26" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="21">Catalyzes three sequential steps of tetrahydrofolate biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(7,8-dihydropterin-6-yl)methyl diphosphate + 4-aminobenzoate = 7,8-dihydropteroate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19949"/>
            <dbReference type="ChEBI" id="CHEBI:17836"/>
            <dbReference type="ChEBI" id="CHEBI:17839"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:72950"/>
            <dbReference type="EC" id="2.5.1.15"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>6-hydroxymethyl-7,8-dihydropterin + ATP = (7,8-dihydropterin-6-yl)methyl diphosphate + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11412"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:44841"/>
            <dbReference type="ChEBI" id="CHEBI:72950"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.6.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>7,8-dihydroneopterin = 6-hydroxymethyl-7,8-dihydropterin + glycolaldehyde</text>
            <dbReference type="Rhea" id="RHEA:10540"/>
            <dbReference type="ChEBI" id="CHEBI:17001"/>
            <dbReference type="ChEBI" id="CHEBI:17071"/>
            <dbReference type="ChEBI" id="CHEBI:44841"/>
            <dbReference type="EC" id="4.1.2.25"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="6">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate: step 3/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate: step 4/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 7,8-dihydrofolate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate and 4-aminobenzoate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">In the C-terminal section; belongs to the DHPS family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">In the N-terminal section; belongs to the DHNA family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="22">In the central section; belongs to the HPPK family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.15" evidence="10"/>
    <dbReference type="EC" id="2.7.6.3" evidence="12"/>
    <dbReference type="EC" id="4.1.2.25" evidence="11"/>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PU89"/>
    <dbReference type="STRING" id="1365484.W6PU89"/>
    <dbReference type="OMA" id="NIPHKLM"/>
    <dbReference type="OrthoDB" id="615426at2759"/>
    <dbReference type="UniPathway" id="UPA00077">
        <property type="reaction ID" value="UER00155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005740">
        <property type="term" value="C:mitochondrial envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003848">
        <property type="term" value="F:2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004150">
        <property type="term" value="F:dihydroneopterin aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004156">
        <property type="term" value="F:dihydropteroate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046656">
        <property type="term" value="P:folic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00739">
        <property type="entry name" value="DHPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00483">
        <property type="entry name" value="HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.20:FF:000006">
        <property type="entry name" value="Dihydropteroate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.560:FF:000005">
        <property type="entry name" value="Folic acid synthesis protein fol1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.560">
        <property type="entry name" value="7,8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.20">
        <property type="entry name" value="Dihydropteroate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045031">
        <property type="entry name" value="DHP_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006390">
        <property type="entry name" value="DHP_synth_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011005">
        <property type="entry name" value="Dihydropteroate_synth-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000550">
        <property type="entry name" value="Hppk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035907">
        <property type="entry name" value="Hppk_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000489">
        <property type="entry name" value="Pterin-binding_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01496">
        <property type="entry name" value="DHPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01498">
        <property type="entry name" value="folK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20941">
        <property type="entry name" value="FOLATE SYNTHESIS PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20941:SF1">
        <property type="entry name" value="FOLIC ACID SYNTHESIS PROTEIN FOL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01288">
        <property type="entry name" value="HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00809">
        <property type="entry name" value="Pterin_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55083">
        <property type="entry name" value="6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51717">
        <property type="entry name" value="Dihydropteroate synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00792">
        <property type="entry name" value="DHPS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00793">
        <property type="entry name" value="DHPS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00794">
        <property type="entry name" value="HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50972">
        <property type="entry name" value="PTERIN_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="19" id="KW-0289">Folate biosynthesis</keyword>
    <keyword evidence="16" id="KW-0418">Kinase</keyword>
    <keyword evidence="18" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pterin-binding" evidence="25">
        <location>
            <begin position="191"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00005013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00005051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00009640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00009951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00012458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00013043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00013253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00022909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00058009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00061548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00067568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00068111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="CDM27753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="465" mass="50837" checksum="DFB05350642BCC6A" modified="2014-04-16" version="1">MNLKFPSPDIHRAFIALGSNVGDRVEMIEQACLEMDRVGIKVKRTSSLFETAPMYVLDQDTFINGVCEVETTLAPLDLLDTIQSIEIAMGRKKLIDKGPRSIDLDILLYDEEIVCHERLNIPHNLMLERDFVLRPLSQLIPNEYPPLPGKDTQTYSTHLKALSPPDPTPMSTTPISPLFPSLRATDPKRSTHVMAILNLTPDSFSDGGKHSPTDLNYITETVRNFIASGATIIDIGGESTRPGSKPVGAAEEIARVVPAIKHIRTAIPEAANIAISIDTYRASVAEAACAAGADIINDISAGLLDPEMLPTVARIGKSVILMHMRGTPQTMTTLHEYPTGVIPEVAAELGARIAAAEDAGIRRWRIILDPGLGFAKIQEHDLEILRDLPRLRAMPGLECFPWLMGPSRKRFIGHLTGVKTPRERVWGTAATVSASVAGGADIVRVHDVHEMWQVAKVADAIYRVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W6PUG6</accession>
    <name>W6PUG6_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Aromatic-ring hydroxylase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PROQFM164_S01g001341</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PUG6"/>
    <dbReference type="STRING" id="1365484.W6PUG6"/>
    <dbReference type="OMA" id="TLLFEPM"/>
    <dbReference type="OrthoDB" id="47494at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47178:SF5">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47178">
        <property type="entry name" value="MONOOXYGENASE, FAD-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004879417" evidence="6">
        <location>
            <begin position="19"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="7">
        <location>
            <begin position="155"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM27530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="403" mass="44299" checksum="0C9E54B52121953A" modified="2014-04-16" version="1">MSHPILIIGAGLGGLCLAQGLKKRNIPFKLFEQDGRHDLRTQGYRLRVGSEGIYALRDNLSPELYALFENTCAETVMGGVRIKPDGTLLGGTGPPRPLGSAAFIEPQTVDRSTFREVLLTGLDEHVFFGKSFDHYTVNDGNIIAFFADGSKETGSLLVGADGVRSRVRKQYIPDFMGIDTGMRIIFGKTPLSPEFLARFPEAYHHGMSLVLNPDDESRTTLLFESIRFPHAEKVSKPQLPDPYVYWVLVTHSSNISSSNGTSWPLSPEKSAELARHVTKSWHPDLQVLFEMQDEAQTSTRLMLSASPELASWEPSPHVTLLGDAIHPMPPTGAMGANTALRDAADLARRLEVAVSSQTLGRHVIGEYESELRDSARTAIALSWQGGMKGFRLKSAVECKKILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W6PUL7</accession>
    <name>W6PUL7_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S01g001267</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PUL7"/>
    <dbReference type="STRING" id="1365484.W6PUL7"/>
    <dbReference type="OMA" id="MGQRNKV"/>
    <dbReference type="OrthoDB" id="3944408at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054505">
        <property type="entry name" value="Myb_DNA-bind_8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22980">
        <property type="entry name" value="Myb_DNA-bind_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb-like DNA-binding" evidence="2">
        <location>
            <begin position="11"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM27456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="266" mass="29447" checksum="6663F96C01A30C0A" modified="2014-04-16" version="1">MGQRHKVLETDTPTAKFLYTIIKQLDLKSVDWNRVASDVEVSNGHAARMRYSRFRQQMEGNTGASKPKRKSKKGKTMDPPAEMQGIFPMAPPLMMPTMASIDSSLPGNPFVKCEPGIQGNANLQSFMQQSPQLMLEASAEGQYYFPQDFASMQFQLASSIPSAIPSPSPARSSSFMQNPYQFPTMPTGYPFSSPGTQSGFDLRDFDQMNPFTSSAPAISWEPRSPSRQEGPTMKAEEGQKQTEEEMSSAGNQEDGHVVVKVEKNLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W6PUM1</accession>
    <name>W6PUM1_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ARS binding protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g001272</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PUM1"/>
    <dbReference type="STRING" id="1365484.W6PUM1"/>
    <dbReference type="OMA" id="GHPHPYY"/>
    <dbReference type="OrthoDB" id="2104370at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018562">
        <property type="entry name" value="ARS-binding_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42048">
        <property type="entry name" value="ARS-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42048:SF1">
        <property type="entry name" value="ARS-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09441">
        <property type="entry name" value="Abp2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="272"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="319"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="32"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="293"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="335"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="352"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="431"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="470"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM27461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="771" mass="85008" checksum="3318F54C33E0AA50" modified="2014-04-16" version="1">MMDSTDRSNRGELGRPQMVIQQYARYPPTLESTLQSASSLGSSRSQIDINKSPPLQRRETPRSLQSSPRGMHSAIPPSSANRSGASMSPPVFDPRRHQPMKDSADHADSRALPSRDITDETIDDAYVSFILYCNPNVPSSVDTSDLRKTFRCLPRSDGKSFNIFTLYGLIRRRLQNEELKTWIQLAIELGVEPPCLEKKQSTQKVQQYTVRLKRWMRAMHIDAFFEYCMGLPHSYYTQLPPSGPFVSESRDGVLLEEDLALRALVPQWKPKRGRKRVEDRYTEEDRAIKRPQLDTSVGAQQQGSFQSHSVAFPQSAIPFSAFPDDAESNDPWIPATSSFPNGSRPDQQNPDIRWRHPERDASPASYPQSAIIPRSHLPSDVLKSAEPRSAVTPSTGEKTRSRRRHGPAVSSAWPNSNGLSAGKGRGRPPNKGSSSGSFSTFQVNPSRESSQAPNSNTQAPSIALDRNPPQIFQTPTHNNPSTSISQGRPNRLQLQVPQHSGAPVRLASPPRLVVNGVNGAVVPGSEGSNEPRQHVTTDTTKNGITTQISSSGGQRNAVITPNPSIDEVVHALSAELLRARLTGQTANLAPNEAAALASEMVINLSSLYSQFYLGTPSLLLALHLGVGHHFGLAGTNPGSLVINVERATPSSDEDRNGPATKESFSDIHYTVFHEYKTSSQFSMQITLAKLNPSMGRKDSPDHANVIMGPSNENIDNDKTANLDFDDDDSSHPVSEATWKQRYTRLRTQMHKKDQALSKYKRKIVESVMADI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W6PV50</accession>
    <name>W6PV50_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Dyp-type peroxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PROQFM164_S01g001482</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DyP-type peroxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PV50"/>
    <dbReference type="STRING" id="1365484.W6PV50"/>
    <dbReference type="OMA" id="WDRVPID"/>
    <dbReference type="OrthoDB" id="76259at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048328">
        <property type="entry name" value="Dyp_perox_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048327">
        <property type="entry name" value="Dyp_perox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006314">
        <property type="entry name" value="Dyp_peroxidase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01413">
        <property type="entry name" value="Dyp_perox_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30521">
        <property type="entry name" value="DEFERROCHELATASE/PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30521:SF0">
        <property type="entry name" value="DYP-TYPE PEROXIDASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20628">
        <property type="entry name" value="Dyp_perox_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04261">
        <property type="entry name" value="Dyp_perox_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51404">
        <property type="entry name" value="DYP_PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 9" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dyp-type peroxidase N-terminal" evidence="7">
        <location>
            <begin position="10"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="Dyp-type peroxidase C-terminal" evidence="8">
        <location>
            <begin position="143"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM27671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="316" mass="35028" checksum="1CCC2557F2380472" modified="2014-04-16" version="1">MSSLTTASIQPVIAPLTRTAIFLVLSITNTSAIPTIRSTLASVSSLAKNVAFRDSDANLTCTVGIGSSVWDELTNNLPRPKELHPFREVKGAKHTAISTPGDLLFHIRSERRDICFEFERQLIDHLGDSVQLVDETVGFRYFDSRDLLGFVDGTANPVGPGILPSVLVTMEDDPHAQDGSYIVVQKYIHDLASWKTLPSEQQEEIIGRTKIDNIELDDAEDGKQASHKTLNTIEDEYGDEHDILRDNMPFGSPASGEFGTYFIGYTRRLWVIEKMLERMFKGHPPGLHDRLLDFSRPLTGNVFFAPSATVLNGLDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W6PV79</accession>
    <name>W6PV79_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Mechanosensitive ion channel MscS</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PROQFM164_S01g001581</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PV79"/>
    <dbReference type="STRING" id="1365484.W6PV79"/>
    <dbReference type="OMA" id="HSMHDVD"/>
    <dbReference type="OrthoDB" id="544685at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023408">
        <property type="entry name" value="MscS_beta-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006685">
        <property type="entry name" value="MscS_channel_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058650">
        <property type="entry name" value="Msy1/2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31323">
        <property type="entry name" value="MECHANOSENSITIVE ION CHANNEL PROTEIN MSY2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31323:SF14">
        <property type="entry name" value="MECHANOSENSITIVE ION CHANNEL PROTEIN MSY2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00924">
        <property type="entry name" value="MS_channel_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25886">
        <property type="entry name" value="Msy1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="128"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="160"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="215"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="254"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="484"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="8">
        <location>
            <begin position="428"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="692"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="833"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="701"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="774"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="901"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="960"/>
            <end position="974"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM27770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="1021" mass="112207" checksum="CF6E32B181DBBE81" modified="2014-04-16" version="1">MGRSSLSIRRLTAHRFEQLHDMPDHSSGNGMLNPNDVTIDIPLTETTSRGQTGARKWNTNTSAQDFHSQTTEKAPIVGVHRGPGGRRRMDTEINEITGKPAESPEDGTINRMGRFYQAVLNYSLVTRYLIYVLPIAILIAIPIIVGATAATYAKIGGVHIYWFFTWIEIVWFSLWVSKLFARYVPYVFQFLCGIVSSGTRKYALILRALETPIALVLWAVISLVTFLPVMTLTPGKKASGDTAPKSWEKSIKNILFALLVCSLIFLAEKALVQLISISYHRKQFDAKIQVSKRNVYLVNLLFEASRNMFPVYCPEFQDEDSLLFDSILVQACNNGGKRSSAMPLRMLRNVGKNVGRVGDKVTAAFGHVASELTGKQVFNPTATHTMVIEALERKRHAAALARRIWMSFVVEGREALYLEDIVEVLGVEHEAEAEECFLALDRDGNGDISLDEMVMTITEFGRMRKALNHSMYDVDQAIRVLDNLLLCVAGLVGVLVFISFVTTGFGTVIAAGATSLLSLSFVFSVTAQEVLGSCIFLFVKHPFDIGDRVEVSDKPFIVERISLLFTVFRNVTDARITQVPNNILNSLWVDNFTRAKAMHEQLVIPVAFDTTFAEVQLLRTEMEHFVRDKDNCRDFQPDIDIELDGVGDMDKLQLRVDIRHKSNWSNETIRAARRSKFLCALVLAVRKIQVRAPGVAPPAAEDADAADGDDKGDDAGAGADVGHRKSTQPGAADSSKPDPGVAAATATAAGGILDHENTAQSTGYDQDRAGTVTHRGSTQTNATQTNAEREAAIVELLNARSPTVDIGRDHYNGHESALHRTASNASHQTHLNVPHGSEGINRGLSTGHRKAGDRASFQEQDTHPALRNPQAPLSPVPAGMTPSSSQVPILETPKPGSRGSARYEPRPHASQDEKSTIQMLGSPDPNRFDGYYSHDTGYNQIPLGGYSAENTPGRDRRDSNPNISSVTASSNYQLSDRYDPASSPSIYSPPQPQPTVPQQAVTYNTAPLRKKEKSPYGEHEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W6PVY9</accession>
    <name>W6PVY9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Nucleoporin, Nup155-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PROQFM164_S01g001891</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus envelope</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleoporin Nup133 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1365484.W6PVY9"/>
    <dbReference type="OMA" id="HVATLLW"/>
    <dbReference type="OrthoDB" id="103454at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000972">
        <property type="term" value="P:transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001057">
        <property type="entry name" value="Nuclear pore complex subunit Nup133, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007187">
        <property type="entry name" value="Nucleoporin_Nup133/Nup155_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014908">
        <property type="entry name" value="Nucleoporin_Nup133/Nup155_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037624">
        <property type="entry name" value="Nup133-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13405">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13405:SF11">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03177">
        <property type="entry name" value="Nucleoporin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08801">
        <property type="entry name" value="Nucleoporin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117289">
        <property type="entry name" value="Nucleoporin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0811">Translocation</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nucleoporin Nup133/Nup155-like N-terminal" evidence="10">
        <location>
            <begin position="98"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin Nup133/Nup155-like C-terminal" evidence="9">
        <location>
            <begin position="643"/>
            <end position="1290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDM28080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="1303" mass="144423" checksum="2209DE8C040158C7" modified="2014-04-16" version="1">MFVPKAGGRNTRRRQRTSSDDSVKPPKAKRQRSVLRRPDESPSDTNLGREIAKLATPTAPNDDITPTDLMNDLHISARGAKQGDGSGNNNEGTIVLSSTDFYTVDQLPSLPDQIRGLQSEPLKCFFGTGHHYALALTRSHAIVWPYSAPASSPSPSETFTVSIPESCRDPKGAVPLGVLLSTATGDHPGLLVIIPSTGKVIYWETVSSAASLGLSRQKQNGIQGSTPGMLSGEYATEILNGEPSGVIVTFSSGRVAHITLRDPQGKPSVVVNFLRSTAGSGGGGIFGGLKNVFAGGSWRKEVTAVRAGGSHQRGQRDIIIATSTGLVEIWDTHWNHGNTLKKRYDLKNEIMDALPEYHAQPTNDTELKVMDFVFSALQSFDDAVQLPDGSWRLFLVVRSPQWLETRTLFVVQVHLSGNESRVMSTHAVDVRHIPVSQLEASKPRLFVPKPEETAFILIGQSLVILSLTSVEETPSSQLLLDSNNLPLPFQDTIHFRSGTEHEILGSISEDQSNDLPCAACVLMLRNFGVIRVTVLPRPSTEQDVEEPQVTAKHKLEQAVFFGTMAKNPLNLSSEGDLNFPPSEMEQASLEICRELLQSETRFIPTTAISLEQNLRLRAKALDDLASLLSRQGNPLSRPAKWELLWAAEKIAAQRAMWKIQEACKTKNGDEETFLGHVIGSMHEKFKTPINAQHGETDPVRQWFLRDSYRMEHIIPWIKNAIKSGRGNTSNPARALSEKILAASELFLAVTETAFRYRDEHVALYGLHGDFLEDGVLSDGYEDLPEFWTSRAVGYSEAGHLLDLELDSCRSWITPASAADTPDTHVLNQVARNSHRHLRVIGQMHLERTRWLSAQGDPKLMDESVSIEQAHVEDRKWQLFKLAGIGHLADAIELAESFRDMGALVELIIELQDQKATQNPRAEPPIDVSTTQTEIDADQLIAKYFDKFGDLWADAYFSRQIAMGYPGTLFTMRKYQSAVTRFLRSNPAYSRLSWINDVIGENDYDTAAVSLENLAIGSEKDLWSHRVEISIAKLGKLATQEQMDSPVVASTLQEDLKRLEDYVEVDGIQDILYQYVEPVLQGAIDEKAELELALGQYGEHIFEDRPSLHEILSDALSTLIDRQVVGADGLVDILTLMGPTQLADDSESEIVRSEFHLALQVLDYGRYGQRDPAYLMALQRLIWRRCLIKDDWVARGKAAEGPNGDAHNSVADTALYRSLTACLEEPRNAGPHSVYTALSPAEALMTDSDSDILVSRFRPEQKARVAADLQTENDILRQCIDVGKLDFWFQNLRETAEVHISPPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W6PW97</accession>
    <name>W6PW97_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="7">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PROQFM164_S01g002001</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PW97"/>
    <dbReference type="STRING" id="1365484.W6PW97"/>
    <dbReference type="OMA" id="FYTIVVE"/>
    <dbReference type="OrthoDB" id="5290825at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050814">
        <property type="entry name" value="Myo-inositol_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020">
        <property type="entry name" value="PROTON MYO-INOSITOL COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020:SF25">
        <property type="entry name" value="SUGAR TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G05830)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM28190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="175" mass="20009" checksum="CF2A3884C000C160" modified="2014-04-16" version="1">MSMAFLFTGFSFWIPESSHNARLACIASGTYLFGVVYSPGEGPVPFTYTAEVYPLYMRSYGMALGTATMWFCNFILAVTWPSLRAAFTIQGAFAWHASWCLVGWWMVLLFMPETKGKTLEELDQVFSVPTRLHAQYGLRQIGVFVQRYLLRRDVRPEVLYEREELVKAQDVGFNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>W6PWC1</accession>
    <name>W6PWC1_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="13">GTP-binding protein rhb1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">rhb1</name>
        <name evidence="13" type="ORF">PROQFM164_S01g001897</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Endomembrane system</location>
            <topology evidence="11">Lipid-anchor</topology>
            <orientation evidence="11">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the small GTPase superfamily. Rheb family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PWC1"/>
    <dbReference type="STRING" id="1365484.W6PWC1"/>
    <dbReference type="OMA" id="SARHNEN"/>
    <dbReference type="OrthoDB" id="5976022at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04137">
        <property type="entry name" value="RheB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000273">
        <property type="entry name" value="GTP-binding protein Rheb homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0488">Methylation</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0636">Prenylation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00046278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDM28086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="187" mass="20897" checksum="A10B0016D22896FC" modified="2014-04-16" version="1">MPSAPKQRKIAIVGSRSVGKSSLTVRFVEHHFVESYYPTIENTFSRIIKHNGQDYATEIVDTAGQDEYSILNSKHFIGIHGYIIVYSVASRQSFDMVRVIRDKILNHLGADDVPLVIVGNKSDLKPDHRQVTLEDGRQLAEELHCAFTEASAFLDFNVSKAFDLMIGEVEKSQNPSQPTGDNKCAVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W6PWJ7</accession>
    <name>W6PWJ7_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Probable transposable element</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S01g000123</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PWJ7"/>
    <dbReference type="STRING" id="1365484.W6PWJ7"/>
    <dbReference type="OMA" id="ASVIYCY"/>
    <dbReference type="OrthoDB" id="4357141at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE-1" evidence="2">
        <location>
            <begin position="177"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="363"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="408"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="469"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM26314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="498" mass="57030" checksum="8DE03248F9325699" modified="2014-04-16" version="1">MSHSAMAARMRRRSEALGPRHGNGVLPEPQTSNDSLTAVEDKAIIDYVERWKDHGFQLKKQSMVSEIASAYFKHHGGSDNGTSRHGGIFARNRDFHEQFKRSRAAEKGEPSNKDPAVEDGKLCEFIDQFAALRSDHRLNNEHIYVLSDTGYATTIQKDKQPLNISRRRSSENRAFASVIYCYPATGKPLSPYVIFKTSKVQGPRRHENRITISYNSSGWAEKTHALDWLNSVFEKETCPFGRRERGQRDRSQRRLLLIDSQFPVTPEFFVTCWERNVICLCLPKKGSEYLNPFENGIFNALDKLYAEHMKKQLRQRCPYTISPSQFATFIDRELGFPDRSTECTNAWFVTCLLPPSRTRLIKRRTGDRIRSQTVEPNSPIRARRRHVSPDENNVGEDDDPISVIVHQEQISSRRSLQGPQHRGTPTQEFPEEPEASENSSDTEHDSEQNEPEQSSSEEESSYFHVPITPSRTPRQLKTPKSSRKLNFLPPSVMFASGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W6PWM9</accession>
    <name>W6PWM9_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">EKC/KEOPS complex subunit GON7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PROQFM164_S01g002017</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. GON7 likely plays a supporting role to the catalytic subunit KAE1 in the complex. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptional coactivators.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the EKC/KEOPS complex composed of at least BUD32, CGI121, GON7, KAE1 and PCC1; the whole complex dimerizes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GON7 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PWM9"/>
    <dbReference type="OMA" id="TETFEHV"/>
    <dbReference type="OrthoDB" id="2288868at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014849">
        <property type="entry name" value="EKC/KEOPS_Gon7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08738">
        <property type="entry name" value="Gon7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0010">Activator</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0779">Telomere</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="9" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="66"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="74"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CDM28206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="89" mass="9751" checksum="8E536C93B7711A7B" modified="2014-04-16" version="1">MASNTSLTAVYTAPHATETFEHVISTTTGTLAAKQAHLSALQSLVPKLQEQINVFLTERMEEDKVQGQISAQEAQEEENYGEEVVEDDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W6PXM7</accession>
    <name>W6PXM7_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Barwin-like endoglucanase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g002794</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PXM7"/>
    <dbReference type="STRING" id="1365484.W6PXM7"/>
    <dbReference type="OrthoDB" id="623670at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22191">
        <property type="entry name" value="DPBB_RlpA_EXP_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051477">
        <property type="entry name" value="Expansin_CellWall"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836:SF28">
        <property type="entry name" value="SRCR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM28983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="95" mass="10540" checksum="7FAE853C863325E8" modified="2014-04-16" version="1">MRPGLDPAAGLITGETTSVPSLVFVFDRANVDGNPNHNALCGRLIHIQRGDRGIDVTLVDRCEGCDEFDIDVSRGVFQTLGNLDEGRVRTDWWWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>W6PXV2</accession>
    <name>W6PXV2_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Queuine tRNA-ribosyltransferase catalytic subunit 1</fullName>
            <ecNumber evidence="6">2.4.2.64</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Guanine insertion enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">tRNA-guanine transglycosylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PROQFM164_S01g000603</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming queuine, allowing a nucleophilic attack on the C1' of the ribose to form the product.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>guanosine(34) in tRNA + queuine = queuosine(34) in tRNA + guanine</text>
            <dbReference type="Rhea" id="RHEA:16633"/>
            <dbReference type="Rhea" id="RHEA-COMP:10341"/>
            <dbReference type="Rhea" id="RHEA-COMP:18571"/>
            <dbReference type="ChEBI" id="CHEBI:16235"/>
            <dbReference type="ChEBI" id="CHEBI:17433"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:194431"/>
            <dbReference type="EC" id="2.4.2.64"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="6">Heterodimer of a catalytic subunit and an accessory subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the queuine tRNA-ribosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.64" evidence="6"/>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PXV2"/>
    <dbReference type="STRING" id="1365484.W6PXV2"/>
    <dbReference type="OMA" id="IDLFDCV"/>
    <dbReference type="OrthoDB" id="10249838at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008479">
        <property type="term" value="F:tRNA-guanosine(34) queuine transglycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.105">
        <property type="entry name" value="Queuine tRNA-ribosyltransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00168">
        <property type="entry name" value="Q_tRNA_Tgt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004803">
        <property type="entry name" value="TGT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036511">
        <property type="entry name" value="TGT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002616">
        <property type="entry name" value="tRNA_ribo_trans-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00430">
        <property type="entry name" value="Q_tRNA_tgt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00449">
        <property type="entry name" value="tgt_general"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43530">
        <property type="entry name" value="QUEUINE TRNA-RIBOSYLTRANSFERASE CATALYTIC SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43530:SF1">
        <property type="entry name" value="QUEUINE TRNA-RIBOSYLTRANSFERASE CATALYTIC SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01702">
        <property type="entry name" value="TGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51713">
        <property type="entry name" value="tRNA-guanine transglycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 6" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="5 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="tRNA-guanine(15) transglycosylase-like" evidence="7">
        <location>
            <begin position="27"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="RNA binding" evidence="6">
        <location>
            <begin position="262"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="RNA binding; important for wobble base 34 recognition" evidence="6">
        <location>
            <begin position="286"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="106"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="6">
        <location>
            <position position="281"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="106"/>
            <end position="110"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="319"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="321"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="324"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="356"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM26794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="415" mass="45449" checksum="BBD931DCA14E06DD" modified="2014-04-16" version="1">MSTTTAPSHKSMPSALTFDRHAKCSTTKARASTLHLPHGSVPLPIFMPVATQASLKGLTYDQLRETGCMLCLNNTYHLGLKPGQAVLDAVGGAHKLQGWDRNLLTDSGGFQMVSLLQLATVTEEGVRFLSPHDGSPMLLTPEHSISLQNSIGSDIIMQLDDVIATTSPDHARIKEAMDRSVRWLDRCIAEHKYPERQNLFCIIQGGLDLELRKQCCEEMVARDTPGIAIGGLSGGEAKEEFCKVVHTCTEMLPEHKPRYVMGVGYPEDIVVAVALGADMFDCVWPTRTARFGDAIVSSGTLKLSHKSFADDFGPVEEGCTCTCCRPTDQGGLGLTRAYMHHITAKETVGAHLLTIHNVHYMLTMMGKIRQAIIDDQYPAFLRKFFSDIYRGDKSNYPEWAVGALRGVGVDLLADS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2024-10-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W6PXV5</accession>
    <name>W6PXV5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g000608</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PXV5"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM26799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="50" mass="5475" checksum="7B11F827887CBD4E" modified="2014-04-16" version="1">MMRGLKKPAQEVGVMPSYLCREEDRAYARSIHGEAQSSSTVRSGMGDAVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2024-10-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>W6PYB6</accession>
    <name>W6PYB6_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S01g000773</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PYB6"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM26964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="109" mass="12378" checksum="DDBB5331743C9FA3" modified="2014-04-16" version="1">MRSMHNINGRHASRMWKPPRAPTSDLDMIHTHPFIVVRLGSINYVHHFMHSNPVRGWLTLALAFSRLRWHLAASLSLWLCFIVHDTSSLGCTLHGICILRSTSDASPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W6PYJ2</accession>
    <name>W6PYJ2_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">7alpha-cephem-methoxylase P8 chain related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S01g000843</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asaB hydroxylase/desaturase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PYJ2"/>
    <dbReference type="STRING" id="1365484.W6PYJ2"/>
    <dbReference type="OMA" id="ISVWRPI"/>
    <dbReference type="OrthoDB" id="412788at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044053">
        <property type="entry name" value="AsaB-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041278">
        <property type="entry name" value="CmcJ_NvfI_EfuI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34598">
        <property type="entry name" value="BLL6449 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34598:SF3">
        <property type="entry name" value="OXIDOREDUCTASE AN1597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM27034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="296" mass="33752" checksum="2A4DB7E240D8EE6D" modified="2014-04-16" version="1">MASAAVQLPGSHGSLLSENPRVPVSEKPHHVQATLNFYKENEDGSPPAPSYVGKPETYDRPVVPLVTTIHDISGHELDYKLDSHGFQLYYHESQEKDFLDDEKIKREYYPETEQLLKDATGASRIFIFDHTIRRAQTDRSITTQLRGPVQRVHIDQSYTASKNRVSHHLPDEAPELLKGRYQIINVWRPIKTILKDPLAVADAHSVPDSDLVPIGLIYPDREGETYAVKPDPNIKWYYRYGQTPDLVTLIKCFDSKVDGRARRVPHTAFVNPETEHEAGRESIEVRALVFHPDDRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>W6PZI4</accession>
    <name>W6PZI4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="20">Protein arg-6, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">arg-6</name>
        <name evidence="20" type="ORF">PROQFM164_S01g001158</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">FM164</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2 17">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 2/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 17">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 3/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 17">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 17">In the C-terminal section; belongs to the NAGSA dehydrogenase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 17">In the N-terminal section; belongs to the acetylglutamate kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PZI4"/>
    <dbReference type="STRING" id="1365484.W6PZI4"/>
    <dbReference type="OMA" id="IAFIPHV"/>
    <dbReference type="OrthoDB" id="438291at2759"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00107"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003991">
        <property type="term" value="F:acetylglutamate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003942">
        <property type="term" value="F:N-acetyl-gamma-glutamyl-phosphate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070401">
        <property type="term" value="F:NADP+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04252">
        <property type="entry name" value="AAK_NAGK-fArgBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23936">
        <property type="entry name" value="AGPR_C_ARG5_6_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd24149">
        <property type="entry name" value="AGPR_N_ARG5_6_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04263">
        <property type="entry name" value="DUF619-NAGK-FABP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000019">
        <property type="entry name" value="Bifunctional acetylglutamate kinase/N-acetyl-gamma-glutamyl-phosphate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000029">
        <property type="entry name" value="Bifunctional acetylglutamate kinase/N-acetyl-gamma-glutamyl-phosphate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1160.10:FF:000011">
        <property type="entry name" value="N-acetyl-gamma-glutamyl-phosphate reductase, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="entry name" value="Acetylglutamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00150">
        <property type="entry name" value="ArgC_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004662">
        <property type="entry name" value="AcgluKinase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023013">
        <property type="entry name" value="AGPR_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058924">
        <property type="entry name" value="AGPR_dimerisation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000706">
        <property type="entry name" value="AGPR_type-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041734">
        <property type="entry name" value="NAGK-fArgBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011241">
        <property type="entry name" value="NAGK/NAGSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000534">
        <property type="entry name" value="Semialdehyde_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006855">
        <property type="entry name" value="Vertebrate-like_GNAT_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00761">
        <property type="entry name" value="argB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01850">
        <property type="entry name" value="argC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23342">
        <property type="entry name" value="N-ACETYLGLUTAMATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23342:SF0">
        <property type="entry name" value="N-ACETYLGLUTAMATE SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04768">
        <property type="entry name" value="NAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01118">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22698">
        <property type="entry name" value="Semialdhyde_dhC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036440">
        <property type="entry name" value="ARG5-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00859">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="Carbamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01224">
        <property type="entry name" value="ARGC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51731">
        <property type="entry name" value="GNAT_NAGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 17" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 17" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="11 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 17" id="KW-0418">Kinase</keyword>
    <keyword evidence="15 17" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="16 17" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="12 17" id="KW-0521">NADP</keyword>
    <keyword evidence="9 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14 17" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="13" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="19">
        <location>
            <begin position="346"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="active site" evidence="18">
        <location>
            <position position="713"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRNR" id="PIRNR036440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CDM27349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="895" mass="97869" checksum="D735D671B219AD6C" modified="2014-04-16" version="1">MCVAKMMSLRSAVRRASCKPLRSLSAPTAPLRVSVKTATSLRQTRNYSRSTDPHLTSTRSTVVQLLSNIGSKREVQQYLSHFTSVSSQQFAVIKVGGAIITEHLQTLSSALAFLNHVGLYPIVVHGAGPQLNRMLEAAGVEPHFEDGIRVTDGKTLALARKLFLEENMKLVEELERIGIRARPITAGVFSADYLDKPKYNLVGKINGVDKAPIESAIAAGCLPILTSMAETPDGQVLNVNADVAAGELARALQPLKIVYLAEKGGLFNGDTGEKISAINLDEEYDHLMSQWWVRHGTRLKIKEMKDLLSDLPRSSSVAIIHPADLQKELFTDSGAGTLIRRGNKVHVKTSLADFGDMKALKEVLIRDREGLDARAVVDRYVEGMKEKDFKIYYDEPMEALAVVLPPQPNSQMAHLATFTITKSGWLTNVADNVFASIKKDFPKLAWTVKEDDENLTWFFDKADGSLSHDGQVLFWYGAANGEEVKQLVQEFNAHGRQMFGDINLEARLHRAAEAAANIGKGFGASGASLEQKRAFSTTTNALRMTRAKRPAVAVNSFRTYATTNPNPPLGEKNISNTQPAKVALIGARGYTGQALINLLNAHPNMDLRHVSSRELAGKKLQGYEKREIIYENLSPEDVRKMSANGEIDCWVMALPNGICKPFVDAVDEGSKTGNVIIDLSADYRFDPNWTYGLPELIERSKIARATRIANPGCYATAAQLGIAPLVPFLGGQPTTFGVSGYSGAGTKPSPKNDVQFLTNNLIPYSLTDHIHEREISSQLGTSIAFIPHVAVWFQGISHSISIPLKQKMTSRDIRNLYQDRYAGEKLVKIVGEAPLVKDIAGRHGVEIGGFAVHSSGERVVVCATIDNLLKGAATQCLQNMNLALGYSEYEGIPLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W6PZW8</accession>
    <name>W6PZW8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="4">LCCL</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S01g003402</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PZW8"/>
    <dbReference type="STRING" id="1365484.W6PZW8"/>
    <dbReference type="OMA" id="WLKGPDP"/>
    <dbReference type="OrthoDB" id="441660at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.20">
        <property type="entry name" value="LCCL-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051957">
        <property type="entry name" value="CRISP-LCCL_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004043">
        <property type="entry name" value="LCCL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036609">
        <property type="entry name" value="LCCL_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31331:SF8">
        <property type="entry name" value="LCCL DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G02970)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31331">
        <property type="entry name" value="LCCL DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G08630)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03815">
        <property type="entry name" value="LCCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00603">
        <property type="entry name" value="LCCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69848">
        <property type="entry name" value="LCCL domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50820">
        <property type="entry name" value="LCCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="113"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="339"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="382"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="422"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="454"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="LCCL" evidence="3">
        <location>
            <begin position="144"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM29590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="691" mass="76670" checksum="0E153074CDC020BA" modified="2014-04-16" version="1">MFGEGREQAARLYVPPLLEDDERLNDPEASEDLPPPDVEAGSTLPVWLQESSKSFRWGWVPLPLRKVGRATVNWVKGPDPPHMLLLKPLFPRFQELPVQYLDHFFPKRKFKTLLLLLLYLSWFLPWFLVLLHSRSSGYIEGYGRPQTLSCSTNFWEVDNGCGINGNDCRPFSSSTIPFRCPANCRDTKLLEPYVVGNNTYNYQGLVIGGPGPDGSDPALYRADSFICQAAIHVGAISNDGGCGVVKLEGAAHSFPSVKQHGILSAGFPSTFPKAFSFLQLSSPQASCPSDPRWTLLGITAAAVGILWLFCTSPPVLFFSTFFMVFCHTGLVGDPPSYPFLADLVSSLLSRLLPASFVVYVLYKFCAAPLLQPISSPIYQLSKLFLFLPPLFTGALNNYTFARLIPLQRLTPMDIQKQPGAKLALALVIPIVISIILSQAWQIRQGGLLPRYLKIYGTMGVIILILLPLPGLRLRIHHYILAILLMPGTAFPTRPSLVYQGLLLGLFINGVARWGFASIIETPAALGEQAPLGDGIHGWWGATYPNITATSVNVSLPELDSNHTYRGNGNITFSLWEHDRMADLAVDGVSLLLNDVERWRGYLDEDKRGEFTWHRHGHDGLELQTNPRLVNRDLDTNIEPRSVLLADSDPDDEPEDLFFRFAFLRGSEAGSYSPTGVWLSDGAWWPPAPPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q014</accession>
    <name>W6Q014_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S02g000007</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM29858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q014"/>
    <dbReference type="STRING" id="1365484.W6Q014"/>
    <dbReference type="OrthoDB" id="2156052at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM29858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="108" mass="12653" checksum="CC679C4DDC5F3296" modified="2014-04-16" version="1">MAEMMVLSYFFNQERKKALTVLRSHRVVHNDSEWRNILWDDLSGQLIVIDLEDVKLLKRRRVLESTSGNTWRSYRVGTGKASKSSCLARQFPTYDDHQTTDHRVSRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q0K5</accession>
    <name>W6Q0K5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lactobacillus shifted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">lbsA</name>
        <name evidence="3" type="ORF">PROQFM164_S01g003603</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q0K5"/>
    <dbReference type="STRING" id="1365484.W6Q0K5"/>
    <dbReference type="OMA" id="SMQAPNR"/>
    <dbReference type="OrthoDB" id="307899at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.40:FF:000003">
        <property type="entry name" value="NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.40">
        <property type="entry name" value="q5lls5 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019401">
        <property type="entry name" value="Znf_CHCC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13156:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 6, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13156">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 13 KD-A SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10276">
        <property type="entry name" value="zf-CHCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zinc finger CHCC-type" evidence="2">
        <location>
            <begin position="128"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM29790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="205" mass="22594" checksum="FD05E8E8C5F01A4D" modified="2014-04-16" version="1">MSCGRRIATFASARPRFVVRAYSSTVPRLSENPIQVNDPTPRKPTPNVSATNAEPTNDGTLQEAPEVGERIRSMQAPNRATTWASSQQPREKAMVGPRFEQTIMESQPRPYAAIELIHRQPVRWTKSRVVSCDGGGGPLGHPKIFINTDKPEIATCTYCGVPFAHEQHRAYLKSLPATSYPLEPTGDAAEVNESQRVTEGGLEQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q0Z7</accession>
    <name>W6Q0Z7_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PROQFM164_S02g000134</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM29985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q0Z7"/>
    <dbReference type="STRING" id="1365484.W6Q0Z7"/>
    <dbReference type="OMA" id="YRLHGVW"/>
    <dbReference type="OrthoDB" id="2533084at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF159">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14230)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="119"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="149"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="179"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="208"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="275"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="318"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="351"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="379"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="413"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="446"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="52"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM29985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="483" mass="53598" checksum="9E4EA765A3F9996A" modified="2014-04-16" version="1">MEKPSPVYFTQEMAASASSSLETHELEECDFDSDLEVKDPLNPRNWSSARKTMLFVSLMTSSLLADGAMVWGGTLVTEQAMDWNITIAHSATSMNYGILLQGFGGIFAVPLIEAYGRLPIWLWPQVITMFMVLGATLSNDWSTFTTFRSLQGLFGTVPQVIGLPIIHDMYTSAEWPRMINIWGTAFLVGPFLGPAIAGYIGAGSDWRISFGVLTAIYGLSTVMVILFGYETYYKPGRMNNQSRLASYFGIGNTLLPKVSTLIYWSRTVVVYVFKFPLLMTGIAILVTFTWPIGITTTIDSFLHSPPYLFDTIEASSMRFAGVIGALCGWAFGHFFNGWIFKRHSSNWRTELRLHGVWFPIGSMASGLLTYGLTMHFGKHWIGIAIGWIMVNIGMVATVVAISAYTLEKYPEQATCVSAILNMWRTCGGFAVGYFQPAWIQRDGLGLVFGIQAAILCVAVALTITPVLLWERKRRLRVDAEADP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q109</accession>
    <name>W6Q109_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyldiphosphate specific]</fullName>
            <ecNumber evidence="5">2.5.1.87</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PROQFM164_S02g000144</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>n isopentenyl diphosphate + (2E,6E)-farnesyl diphosphate = a di-trans,poly-cis-polyprenyl diphosphate + n diphosphate</text>
            <dbReference type="Rhea" id="RHEA:53008"/>
            <dbReference type="Rhea" id="RHEA-COMP:19494"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="ChEBI" id="CHEBI:136960"/>
            <dbReference type="ChEBI" id="CHEBI:175763"/>
            <dbReference type="EC" id="2.5.1.87"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the UPP synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.87" evidence="5"/>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM29995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q109"/>
    <dbReference type="STRING" id="1365484.W6Q109"/>
    <dbReference type="OMA" id="AWSSCAG"/>
    <dbReference type="OrthoDB" id="19639at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904423">
        <property type="term" value="C:dehydrodolichyl diphosphate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045547">
        <property type="term" value="F:ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyl diphosphate specific] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1180.10">
        <property type="entry name" value="Decaprenyl diphosphate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038887">
        <property type="entry name" value="Nus1/NgBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036424">
        <property type="entry name" value="UPP_synth-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21528">
        <property type="entry name" value="DEHYDRODOLICHYL DIPHOSPHATE SYNTHASE COMPLEX SUBUNIT NUS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21528:SF0">
        <property type="entry name" value="DEHYDRODOLICHYL DIPHOSPHATE SYNTHASE COMPLEX SUBUNIT NUS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64005">
        <property type="entry name" value="Undecaprenyl diphosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="70"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="32"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CDM29995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="356" mass="40092" checksum="566F5FBE52268364" modified="2014-04-16" version="1">MVSQRDREILRGDLRARGTKLSIAERESLLKSYLPDPTELGQKPSPQSTSERRKTPRKTPVRTFLKSQTYYLTYAITHIIFGIVVRLLQAYHAVIDRIFAIVYHHHRTPELIRKDVKNLKRLPQHLSAILTLRKEDDALAVLMDEIAELAAWSSCSGICQLSIYEKSGVLKSCIPALHQIITTKLASYYGTPSHQPNLQLYAPHHPVHRSAPISKNIDTTTQPETLTILLLSSTDGRETLVDLTKTLADMSQNGKLSPEDITPELVDAEISEITTQPLSMDPTMPDTLLKPEPDLLLVFGPFLKLDGYPPWQLRLTEMYCTGGRSHGIIGDGEAVEYQGYMRGLWHFAGAQMRFGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q1T9</accession>
    <name>W6Q1T9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Purine permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">uapC</name>
        <name evidence="9" type="ORF">PROQFM164_S01g001990</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q1T9"/>
    <dbReference type="STRING" id="1365484.W6Q1T9"/>
    <dbReference type="OMA" id="GLGFDWN"/>
    <dbReference type="OrthoDB" id="1641903at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042907">
        <property type="term" value="F:xanthine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006043">
        <property type="entry name" value="NCS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006042">
        <property type="entry name" value="Xan_ur_permease"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00801">
        <property type="entry name" value="ncs2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42810">
        <property type="entry name" value="PURINE PERMEASE C1399.01C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42810:SF2">
        <property type="entry name" value="PURINE PERMEASE C1399.01C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00860">
        <property type="entry name" value="Xan_ur_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01116">
        <property type="entry name" value="XANTH_URACIL_PERMASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="69"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="136"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="184"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="208"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="264"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="295"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="334"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="421"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="449"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="481"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="521"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="554"/>
            <end position="577"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM28179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="577" mass="61062" checksum="915FD4842CA5CB21" modified="2014-04-16" version="1">MDGPDQIGPDHSPKRTISDRLRYTVKTFTTREGLLGEYDYGYLFIPRLPFTKRARKSAPFFGLEDRVPVVLALILGLQHALAMLAGVISPPILLGGSAGANFGDELYQYLVSTSLIVSGLLSAVQMFRFHIKGTKYYIGTGLLSVVGTSFSTITVAQGAFAQMYKSGYCPSSPDGSPLPCPKGYGALLGTSCLCSLLEIGMSFMSSKILARVFPPLVTGPTVLLIGASLIKSAMTDWAGGASCGSDPSARALCPSASAPHPLPWGSPQFIGLGFLVFVTIIVCERWGPPILKSCSVIVGLLVGSIVAAACNYFESAGIAAAPVASFAWVHTFPLSVYPPLILPLLALYIVIMMESIGDITATCDVSRLQVEGETFDSRIQGGVLGNGITCLLAGLMTISPMSVFAQNNGVIALTKCANRTAGYCCCLFLVIMGIFSKFAAALVAIPSPVLGGMTAFLFSSVAVSGLRIIGSVEPTRRNRFILTASFSIGMGVTLLPAWFTYFFTYSGDNHALAGLINAVDLVMENGFAISALLGIFLNLFIPEEPDDVPAILESTDSNETQVQTNMPEQSSTTTKMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q240</accession>
    <name>W6Q240_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S02g000514</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q240"/>
    <dbReference type="STRING" id="1365484.W6Q240"/>
    <dbReference type="OrthoDB" id="2744543at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM30365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="59" mass="6540" checksum="AD51A77708E3516E" modified="2014-04-16" version="1">MLVKWGCDLADKDGVMAYVDASKEGAFLYQKHNFVDFSPPGSEVASMARRHQVVPSDHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q2Z4</accession>
    <name>W6Q2Z4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S02g000845</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q2Z4"/>
    <dbReference type="STRING" id="1365484.W6Q2Z4"/>
    <dbReference type="OrthoDB" id="4353558at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM30695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="52" mass="5852" checksum="661DF8C28C472894" modified="2014-04-16" version="1">MGCKDAASADNYLRLWDDRVYVAPSGSRLIGIYMRCQEFCCVGALYEPKVSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q3N9</accession>
    <name>W6Q3N9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S02g001373</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q3N9"/>
    <dbReference type="OMA" id="CFECCEH"/>
    <dbReference type="OrthoDB" id="4153865at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM31223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="88" mass="9427" checksum="929364CF7D491438" modified="2014-04-16" version="1">MFANSLFSWFSFKESIPTSTSDATTGTENHQPVSPKAPSTDPMVTEQPNSQENMLKLELRGGGTGDVCCGLCAGLLCFECCECCECCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q3S8</accession>
    <name>W6Q3S8_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mitochondrial thiamine pyrophosphate carrier 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LEU5</name>
        <name evidence="15" type="ORF">PROQFM164_S02g001393</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mitochondrial transporter that mediates uptake of thiamine pyrophosphate (ThPP) into mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q3S8"/>
    <dbReference type="STRING" id="1365484.W6Q3S8"/>
    <dbReference type="OMA" id="VYERMKW"/>
    <dbReference type="OrthoDB" id="270584at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24089">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="352"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="66"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="165"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="292"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="19"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CDM31243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="384" mass="41703" checksum="3CBDAEEBD1FF9E35" modified="2014-04-16" version="1">MSTGHLDYAYDPPKIPDSTPQFAPMSVAHSASPPVGGATKSFKSNSTADMGIPESGKNKIEKRSFDYVMRSGIAGGLAGCAAKTVVAPLDRVKILFQSSNPQFAKYTGSWTGLASAIRDIKRNEGTRGLYKGHSVTLLRIFPYAAIKFLAYEQIRAVIIPSSEFETPFRRLISGSLAGVTSVCFTYPLELMRVRMAYETRQSKHLGLVKSSSVAAAESASAAASKVFPRSGIANFYRGFSPTILGMLPYAGMSFLTHDTVGDLFRLPSVARYTLRRPEELAHSADRPKRPQLNTTFELLSGAVAGLVSQTSSYPLEVLRRRMQVSGAVGDGRRLGIAETARAIWLERGFRGFWVGLTIGYAKVIPMVAVSFYVYERAKGSLGIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q439</accession>
    <name>W6Q439_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ubiquitin-activating enzyme E1 1</fullName>
            <ecNumber evidence="4">6.2.1.45</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">UBA1</name>
        <name evidence="14" type="ORF">PROQFM164_S02g001265</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + ubiquitin + [E1 ubiquitin-activating enzyme]-L-cysteine = AMP + diphosphate + S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine.</text>
            <dbReference type="EC" id="6.2.1.45"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the ubiquitin-activating E1 family.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.45" evidence="4"/>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q439"/>
    <dbReference type="STRING" id="1365484.W6Q439"/>
    <dbReference type="OMA" id="GANLHAF"/>
    <dbReference type="OrthoDB" id="10252231at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031510">
        <property type="term" value="C:SUMO activating enzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019948">
        <property type="term" value="F:SUMO activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004839">
        <property type="term" value="F:ubiquitin activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01491">
        <property type="entry name" value="Ube1_repeat1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01490">
        <property type="entry name" value="Ube1_repeat2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2660:FF:000001">
        <property type="entry name" value="Ubiquitin-activating enzyme E1 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12550:FF:000001">
        <property type="entry name" value="Ubiquitin-activating enzyme E1 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000015">
        <property type="entry name" value="Ubiquitin-activating enzyme E1 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.180:FF:000001">
        <property type="entry name" value="ubiquitin-like modifier-activating enzyme 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.290.60:FF:000002">
        <property type="entry name" value="Ubiquitin-like modifier-activating enzyme 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.80:FF:000001">
        <property type="entry name" value="ubiquitin-like modifier-activating enzyme 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.180">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, FCCH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.80">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, inactive adenylation domain, subdomain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12550">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, inactive adenylation domain, subdomain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2660">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, SCCH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.60">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, UFD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032420">
        <property type="entry name" value="E1_4HB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032418">
        <property type="entry name" value="E1_FCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042302">
        <property type="entry name" value="E1_FCCH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018965">
        <property type="entry name" value="Ub-activating_enz_E1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042449">
        <property type="entry name" value="Ub-E1_IAD_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038252">
        <property type="entry name" value="UBA_E1_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019572">
        <property type="entry name" value="UBA_E1_SCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042063">
        <property type="entry name" value="Ubi_acti_E1_SCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018075">
        <property type="entry name" value="UBQ-activ_enz_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033127">
        <property type="entry name" value="UBQ-activ_enz_E1_Cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000011">
        <property type="entry name" value="UBQ/SUMO-activ_enz_E1-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01408">
        <property type="entry name" value="Ube1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF4">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1 C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16191">
        <property type="entry name" value="E1_4HB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16190">
        <property type="entry name" value="E1_FCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09358">
        <property type="entry name" value="E1_UFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10585">
        <property type="entry name" value="UBA_E1_SCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01849">
        <property type="entry name" value="UBIQUITINACT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00985">
        <property type="entry name" value="UBA_e1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00865">
        <property type="entry name" value="UBIQUITIN_ACTIVAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin-activating enzyme E1 C-terminal" evidence="13">
        <location>
            <begin position="899"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="777"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="10">
        <location>
            <position position="605"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00073786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDM31115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="1033" mass="115100" checksum="7B3486E66047D412" modified="2014-04-16" version="1">MTDIKMQVENPQETIEAIKHGEIDESLYSRQLYVLGHEAMKRMGSSNVLIVGLKGLGVEIAKNIALAGVKSLTLYDPAAVAISDLSSQFFLQPEDVGKPRAEVTAPRVAELNSYVPVTVHEGQSLVGDLERLKHYQAVVLTQTPLKEQLVIADFCHKNNIYLTITDTFGLFGYIFNDFGKNFTVGDPTGEEPAGGIVAAINEEGLVSALDETRHGLEDGDFVTFTEVKGMDGLNNSDPRKVTVKGPYTFTIGDVSGLGSYEGGGLFAQVKMPKFIDFQPLEDQLKKPELLMSDYAKFDRPQQLHIGIQALHKFAETHDGQLPHPHNDSDAQEVLKIANDLAATDEEKVELDEKIIKELSYQARGDLNPLAAFFGGIAAQEVLKAVSGKFSPIHQWLYFDSLESLPSSVTRSEESCKPLGTRYDGQIAVFGKEYQDKLANVTEFLVGSGAIGCETLKNWAMMGLGTGPKGKLYVTDMDQIEKSNLNRQFLFRTKDVGRLKSECASAAAQAMNRELKDKIVTLRDRVGADTEHVFNEDFWNGLDGVTNALDNVDARTYVDRRCVFFRKPLLESGTLGTKCNTQVVLPFITESYSSSQDPPEKSFPMCTLKSFPNRIEHTIAWARDVFQTYFVGPPESVNMYLSQPDYIQQTLKQAGNEKQTLEHLRDFLVTEKPLTFDDCIVWARQQFEAQYNNAIQQLLYNFPRDSKTSSGQLFWSGPKRAPTPLKFDSTNPTHLGFVIAGANLHAFNYGIKNPGADKDYYRRVVDDMIVPEFTPSSNVKIQANENDPDPNAQPAGLSNDEEEIQKLVASLPSPKSLAGFRLQPVEFEKDDDTNHHIDFITAASNLRADNYEIPQADRHKTKFIAGKIIPAIATTTALATGLIGLELYKIVDGKDDIEQYKNGFVNLALPFFSFSEPIGSEKGKYQGKQGEVTIDKLWDRFEVEDIQLQEFLDFFAEKGLDITMVSSGVSLLYASFYPPSKVKDRLPLPMSKLVEHVSKKPVPEHQKNIIFEVTAEDQTEEDVEVPYVMVKLTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q546</accession>
    <name>W6Q546_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Pre-mRNA-splicing factor isy1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">isy1</name>
        <name evidence="9" type="ORF">PROQFM164_S01g003111</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in pre-mRNA splicing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ISY1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q546"/>
    <dbReference type="STRING" id="1365484.W6Q546"/>
    <dbReference type="OMA" id="YHWERRI"/>
    <dbReference type="OrthoDB" id="1739576at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000350">
        <property type="term" value="P:generation of catalytic spliceosome for second transesterification step"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.660:FF:000001">
        <property type="entry name" value="pre-mRNA-splicing factor ISY1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.660">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029012">
        <property type="entry name" value="Helix_hairpin_bin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009360">
        <property type="entry name" value="Isy1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037200">
        <property type="entry name" value="Isy1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13021">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR ISY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06246">
        <property type="entry name" value="Isy1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140102">
        <property type="entry name" value="ISY1 domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="196"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="196"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM29299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="250" mass="28612" checksum="4291A372E6BD198D" modified="2014-04-16" version="1">MARNSEKAQSMLFRFRAQQAADLGIIDVSRTRRPKAITSIDTVPVCERWRGQVVKEISRKVSRIHVQSLSDYQIRDLNDEINKLMREKWAWEMQIRNLGGPNYMRGSNRLYDDEGREIPGGGRGYKYYGRARELPGVKEMIEAAVTRAKGPAEEEAVSGRGGDIATRKVDANYFGYGLDEEDGTLLAYEKQKEKESVEHLRHQGEDDAEDGWQSLPGDAGDGVEWRLPTLDEVQEELVDRRRRRLLDKIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q565</accession>
    <name>W6Q565_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD(P)-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S02g001924</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q565"/>
    <dbReference type="STRING" id="1365484.W6Q565"/>
    <dbReference type="OMA" id="GSSQVWN"/>
    <dbReference type="OrthoDB" id="68575at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004881796" evidence="1">
        <location>
            <begin position="23"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM31773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="415" mass="45591" checksum="EFD2614B25239621" modified="2014-04-16" version="1">MFLSRLPSVVTFWLAVAITGNTFDPKNYAKADVLVCDVAVVGGGSSGTYAAINLRKMGQSVVVVERKKHLGGHTNTYTDKATGLTVDYGVQSFLNSSIALDYFAHFNISLVKYTESNATISLTDFNTGNPVLFNPSRNLTGWAIQVAQYPWLDSTWEIPQPVPPDLLLPLGDFLVKYNISDAAFNIYFSSQGISNPLQQLTVNVMKMVDAAYLREIAGARLNAADKNNSELYVKSLAELGSDALISSTVTAAARPQTGRGVSLVVKTTTGFKLVQASKLLVNIPPTLENMRPFNFNLQELQMFSHIRIPGVFYVWYRSPSHMTRLAVEQATIRAIQNLQEAQNVTITTPQIINLNSHTPFKLSVSAQAIRDGFYNDLYALQGKRSTWYTGAALISHNGGVLWKFTQALLPRIVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2024-10-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q599</accession>
    <name>W6Q599_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S02g001301</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q599"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM31151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="68" mass="7789" checksum="DEDFDFF2359A3D87" modified="2014-04-16" version="1">MRASEWSGMGKKWGPLNQPTLSGLSRYTTSSVYPFLSCPWVVYNTDQQRGIVQCGKCGRFYELYELSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q5G7</accession>
    <name>W6Q5G7_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S02g001730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q5G7"/>
    <dbReference type="STRING" id="1365484.W6Q5G7"/>
    <dbReference type="OrthoDB" id="4177740at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM31580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="164" mass="18861" checksum="DBDDEB4064FCE1DE" modified="2014-04-16" version="1">MASSLVDPQERAHLRDKYKKAVRSIVYKLQSQSKPTYTYTELAQFRVSVQSIDPEDHTFTDSEACLFRPLTHEELETFKMDKEALPRDGYHYINEFKDTLLMLQAMFPRIASCGRELVKLPSILKSLSHGLRGRTGGRRGGGRGRGEDRSPRYRTFRIGIISSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q7Y7</accession>
    <name>W6Q7Y7_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">SNF1</name>
        <name evidence="16" type="ORF">PROQFM164_S02g002267</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q7Y7"/>
    <dbReference type="STRING" id="1365484.W6Q7Y7"/>
    <dbReference type="OMA" id="TEWHPIS"/>
    <dbReference type="OrthoDB" id="193931at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12122">
        <property type="entry name" value="AMPKA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14079">
        <property type="entry name" value="STKc_AMPK_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14334">
        <property type="entry name" value="UBA_SNF1_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000407">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000069">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000236">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.80">
        <property type="entry name" value="Kinase associated domain 1, KA1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032270">
        <property type="entry name" value="AMPK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028375">
        <property type="entry name" value="KA1/Ssp2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013896">
        <property type="entry name" value="SNF1_UBA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF110">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16579">
        <property type="entry name" value="AdenylateSensor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08587">
        <property type="entry name" value="UBA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103243">
        <property type="entry name" value="KA1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="66"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="405"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="550"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="601"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="677"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="16"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="27"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="52"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="405"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="689"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CDM32116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="788" mass="88931" checksum="6B5AEAD9E4C29A1B" modified="2014-04-16" version="1">MAAAFDEEDLAIPLPSDRDRPRERARPPASNPSAMAMPAPSRPTSKIEDPLQSPSTTRDMQRLDQYQTIRVLGEGSFGKVKLAIHQPTGRQVALKIISRRKLLSRDMVGRVEREIQYLQLLRHPHIIKLYTVIATKTDIVMVLEYAERELFDYLVRKGRCGDDEARKFFQQIICAVEYCHRHKIVHRDLKPENLLIDNQKNVKIADFGLSNIMTDGNFLKTSCGSPNYAAPEVISGKLYAGPEVDVWSCGVILYVLLVGRLPFDDDYIPALFKKIAAGTFHIPGYVSSGAARLIRAMLQVHPVHRITIPEIREDPWFKKNLPKYLEPPREEFIAPGVDPKKVDSARLDIAKPISVQSKIHRIAVSKLERSMGYGREDIEEALRQAEPSAIKDAFSIVVENEMMQTNSPSDDNLLAQNAQKGAAPSSADRTPAPRHQGTPAAPTMDRTASASRRRASEDPQQSDEDELRVSHVRILPTSLPYVHDQLMEQRDRDKRARNQMLEQRRQEAIKLDPEGQGSAYRDMSPEEQAATARALKPHSRSVVDLDKLRFEPPTGQPLEKQPKRSRKWQFGIRSRNQPYEAMLYLYRAIAAQGGLWDIQPVESGTNIGPDATPSPDKPKPLQSKYPDLPSDYYIPKDPWFIRARLLKEGINPPGDTTSAYSSRSDLEELRRRFNISGISAPTEDRSREPQSSVPESASAASSVNVPSGLQKITYGVWVFLDIQLYQLEENNYMVDFKCDGYQNVIRAHGETEWHPISRRLKNKEKEVTSPYPFLDVASDLVAQLAVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q8L7</accession>
    <name>W6Q8L7_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S02g002881</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q8L7"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM32730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="58" mass="6790" checksum="5EB744EF4A28E0D8" modified="2014-04-16" version="1">MDTLDYRNLCNCAIGIIIGTLRFSYFIIYLLIGLQRLVYMKRHVILSIVRFIPGLLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q918</accession>
    <name>W6Q918_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S02g000864</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q918"/>
    <dbReference type="OMA" id="KAGHECP"/>
    <dbReference type="OrthoDB" id="5410040at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40020">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40020:SF1">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004881864" evidence="2">
        <location>
            <begin position="29"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM30714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="142" mass="15677" checksum="8E4C539DB4BD16F3" modified="2014-04-16" version="1">MPPHLHPRSRSTTGLFAGTLLASLLVVGMPHVFPCPAPRRTFADSEMTMTANGQQIPRIRRRRRKDGEVGPDDIQLGQPMPDVVDEEVSTFLQMKAEAEKLSHINRECPVPKPKGVIGELLGFRDIHANAHHQSTALSEGDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2024-10-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q977</accession>
    <name>W6Q977_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S01g000101</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q977"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM26292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="67" mass="7246" checksum="097084643AC42A07" modified="2014-04-16" version="1">MKFKLLVIPRGDIVHASCEEFAINPGSENDGSMQLAHETGVDWQLGLSSTDDKDADAHGSFEVVIDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q9M4</accession>
    <name>W6Q9M4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glucose-fructose oxidoreductase, bacterial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PROQFM164_S01g000281</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfo/Idh/MocA family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q9M4"/>
    <dbReference type="STRING" id="1365484.W6Q9M4"/>
    <dbReference type="OMA" id="IGHVHAR"/>
    <dbReference type="OrthoDB" id="446809at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006740">
        <property type="term" value="P:NADPH regeneration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055170">
        <property type="entry name" value="GFO_IDH_MocA-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42840:SF3">
        <property type="entry name" value="BINDING ROSSMANN FOLD OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G10240)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42840">
        <property type="entry name" value="NAD(P)-BINDING ROSSMANN-FOLD SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22725">
        <property type="entry name" value="GFO_IDH_MocA_C3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="3">
        <location>
            <begin position="6"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="GFO/IDH/MocA-like oxidoreductase" evidence="4">
        <location>
            <begin position="139"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDM26472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="353" mass="38895" checksum="51164E465710C326" modified="2014-04-16" version="1">MSAPKLRVGIAGLGRMGQRHALNYHVFTPRAEVVAASSPDLNEHVWAKENLTGAKIYTDYYEMLEKENLDAVVVAGITAVHADHAIAAIKKGLHVMCEKPLSLDVKIAQSVLDAYNTSLKTHPNQKVMCGFSRRFDASYREAYERMTSGQYGRPVIFRSQTADMLDTTGMFVQYAKTSGGIFLDCSIHDIDLMLWFLGETTHLKSLQAVGVIAVHTALDASKDRDNAVATVEFDGGKIATLFCSRMMAAGQEDTTEVICEKGSLRVNMQGRKNHLEIHDGQGARRDLPKHYYERFREAFLTEANEFTASCLDNTPPPVSLSSSVKAVVIGAALQKSLVTGEKIFFESGKEARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q9W6</accession>
    <name>W6Q9W6_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cell division control protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PROQFM164_S02g001119</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the CDC6/cdc18 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q9W6"/>
    <dbReference type="STRING" id="1365484.W6Q9W6"/>
    <dbReference type="OMA" id="LFEWSLH"/>
    <dbReference type="OrthoDB" id="1926878at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000094">
        <property type="entry name" value="Cell division control protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000547">
        <property type="entry name" value="Cell division control protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016314">
        <property type="entry name" value="Cdc6/18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015163">
        <property type="entry name" value="Cdc6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054425">
        <property type="entry name" value="Cdc6_ORC1-like_ATPase_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050311">
        <property type="entry name" value="ORC1/CDC6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10763:SF26">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 6 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10763">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22606">
        <property type="entry name" value="Cdc6-ORC-like_ATPase_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09079">
        <property type="entry name" value="WHD_Cdc6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001767">
        <property type="entry name" value="Cdc6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 10" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="9">
        <location>
            <begin position="205"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="115"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="575"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="64"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR001767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDM30969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="641" mass="70053" checksum="CE99A4B949B75C08" modified="2014-04-16" version="1">MAGTVLGKRTRGVADPALPVRTASKRRTVVPRAHQQDTVPTSLRRTRSTVKKAVEQPDQENGESKTASENVSSKHTLRDDQFKSPVKINSHFTVSKPVEEEITKPIEFEFKTPSKSRFRDDLPQSPVTPRHRVQVGAKAVTPRTPRHADLPPTPRQSATPKIVNSVYSQARQLFARGSNSGRLVGRDAEREKLISFITEGVNSRKGGCLYISGPPGTGKSAMVQEVCGDLDLSKVKVSHVNCASMRISRDVYSRLIQDFCEDSDMFKKSEGDRLKSTFIPSKKGQDMFLVTLDEIDHLLNGDSGVLQSLFEWSLQSKSKLMLIGIANALDLTDRSLPQLKAKNLKPRLLPFLPYSAASIANVMTNRLRSLLPAGAESDPKLVPFVQPAAIQLCSKKVASQTGDLRKAFELIKRAIDVIEQETLQKLDKQAKESENVSILGENTNLSSPAKVGGAPKPTSMSSYTVITAPRASIAHIARITSAAFGQGTVQRLQSLNLQQKAAICSLIALERKRRQFEVPSTPSKSRTSAPTIKQAFDTYCALCRNDNILHPLTATEFKDVLSNLETMGLVGEYQGRGRGGTVAGGTDLRRTPSKSGHAPSTPHKALDEQALVCFVSQQEIESQIVGPGEGILRRLLRGEGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q9X2</accession>
    <name>W6Q9X2_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S02g002932</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q9X2"/>
    <dbReference type="STRING" id="1365484.W6Q9X2"/>
    <dbReference type="OrthoDB" id="3034003at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM32781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="84" mass="9132" checksum="DEEB2590B9D7DBAF" modified="2014-04-16" version="1">MVELTVSQVAGIIAALVFVVQLLLPVILGALLTGILKPENNLTTWSVVSRFLHSSYWPNILGSDSVASRSVHRPVLAVIWSRPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W6QA45</accession>
    <name>W6QA45_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein kinase-like domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S02g003402</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM33250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QA45"/>
    <dbReference type="STRING" id="1365484.W6QA45"/>
    <dbReference type="OMA" id="QTDGWHD"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990604">
        <property type="term" value="C:IRE1-TRAF2-ASK1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070059">
        <property type="term" value="P:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036498">
        <property type="term" value="P:IRE1-mediated unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045133">
        <property type="entry name" value="IRE1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13954">
        <property type="entry name" value="IRE1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13954:SF6">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="50"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM33250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="271" mass="31392" checksum="3DA18FCA2843B959" modified="2014-04-16" version="1">MEIIRESTSFETLDGRVMYCCKNFVVRQDGILYYGSWNDRSSKPTDISQFNDLRTITTNDRGPKMQDTWAVASEEDCYLKTPGVVDFLYSKLEDDIQCELKVCEVLRRHPHPNIATYYGCREENGRATGLCFKRYKESLTEKVNPGYLNKNMFRASGREQVDDSLRENFHGILEGIKHLHSLGLVHNDINPFNIMLDEHGVPVIIDFGSCRKTGESLNNSRVGQTDGWHDSKNKLVLEKNDLDAFEELKTWLFGSVDDEYLFHEEYQFEEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W6QA90</accession>
    <name>W6QA90_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Neutral ceramidase</fullName>
            <ecNumber evidence="5">3.5.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PROQFM164_S03g000019</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>an N-acylsphing-4-enine + H2O = sphing-4-enine + a fatty acid</text>
            <dbReference type="Rhea" id="RHEA:20856"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:52639"/>
            <dbReference type="ChEBI" id="CHEBI:57756"/>
            <dbReference type="EC" id="3.5.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="4">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the neutral ceramidase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.23" evidence="5"/>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QA90"/>
    <dbReference type="STRING" id="1365484.W6QA90"/>
    <dbReference type="OMA" id="GTTVQTC"/>
    <dbReference type="OrthoDB" id="191371at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017040">
        <property type="term" value="F:N-acylsphingosine amidohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046514">
        <property type="term" value="P:ceramide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042759">
        <property type="term" value="P:long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046512">
        <property type="term" value="P:sphingosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.2300:FF:000004">
        <property type="entry name" value="Neutral/alkaline nonlysosomal ceramidase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2300">
        <property type="entry name" value="Neutral/alkaline non-lysosomal ceramidase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006823">
        <property type="entry name" value="Ceramidase_alk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038445">
        <property type="entry name" value="NCDase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031331">
        <property type="entry name" value="NEUT/ALK_ceramidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031329">
        <property type="entry name" value="NEUT/ALK_ceramidase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12670">
        <property type="entry name" value="CERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12670:SF1">
        <property type="entry name" value="NEUTRAL CERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04734">
        <property type="entry name" value="Ceramidase_alk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17048">
        <property type="entry name" value="Ceramidse_alk_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Neutral/alkaline non-lysosomal ceramidase N-terminal" evidence="6">
        <location>
            <begin position="59"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="domain" description="Neutral/alkaline non-lysosomal ceramidase C-terminal" evidence="7">
        <location>
            <begin position="590"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="314"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="264"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="512"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="552"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR606823-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606823-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU366019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM33295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="763" mass="83138" checksum="C65E980C99C0CF80" modified="2014-04-16" version="1">MAHFRMGVTFVGVTLALLVFLQLSAVFKLDSQSQLPSPSFISNFNQWRSRASSAATDIFVVGAGKADVTGPVVELALAGYANLDQLGTGLKQRLYSHAFIFADPDKPDDTFVYLVVDTLAGDTAVRHGVLEGLTALGGEYARYGEHNVAMTGTHSHSGPGAWMNYLLPQIPALGFDKQSYQAIVDGTILSIVRAHENLAPGRLSFGSIDLQDTNTNRSPFSYEHNPEEERARYSANVEKSLSLIRFDRESDNKTAAVLTWFPVHGTSMYNNNTLVSGDNKGVAAYLFERSVHGDARFTEDAVIGFSQASVGDTSPNILGAWCEDGSGEMCRYEDSTCGGKNENCHGRGPFFRENDNGAKSCFEIGRRQYLAAKKLYEEMDTTPIKIIGGSAVKSFHVYQDMNGYTFPSPFNSSTLTTCSAALGYSFAAGTTDGPGAFDFTQNATGPAERNPLWQVARAVIHQPSEAQQQCQSPKDVLLDIGTLTEPYAWAADIVDIQVLRVGQLFLIISTSEATTMSGRRWKEAIAKEAKNQLLISDPLVVLGAPSNSYAHYVATEEEYGAQRYEGASTLYGPNTLAGYVNLTLTYLPYLGSSSGVAKLPAIQPGPNPSINTNRSLSFIAGVVYDGAPIGKHFGNVTSNPGSGPYGPGDIVKTTFVGANPRNNLHLESTYAAVERKSDSGTWEVVRNDRDWNLVFMWKRTNEILGHSEVTIQWEIEDEYYNVDTTSPLQAGTYRMHYYGDSKNIFGQISPFEGISETFTVNTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W6QAF4</accession>
    <name>W6QAF4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WD40/YVTN repeat-like-containing domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S03g000099</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QAF4"/>
    <dbReference type="STRING" id="1365484.W6QAF4"/>
    <dbReference type="OMA" id="CTINQFR"/>
    <dbReference type="OrthoDB" id="341486at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037593">
        <property type="entry name" value="MIOS/Sea4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16453:SF9">
        <property type="entry name" value="GATOR COMPLEX PROTEIN MIOS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16453">
        <property type="entry name" value="WD40 DOMAIN-CONTAINING PROTEIN MIO FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM33375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="539" mass="59809" checksum="F7AB4EF2F6E46166" modified="2014-04-16" version="1">MESAIRWSPTSSATEQRFLSVDVTGKSFRLCRVNGFDGKYIRHEVLSTLTNVPGFRAFDWSTSNENLIAVGQSSGEATILRLDGDAKESLSFPVRNQRYCNAVAFSTHGLVASGLDRVRNDFCLNIWDVNQRLSPAGGSKGFTEPLRKLASSEPITSIKFFRDQPDTIVTGVKGQFVRIYDLREGPGNPSLQFPTRCVHNLAIDWLDENYIASCIPTNESTICVWDRRVGTRLTSPAIGSSASATDSGQTTPALELKNVFHPKSSIWSLRFSRTNRGSLAALSSSGHFKNYDISKDYLPEEYRSSIDETLGQGSSRNYPESVYTKHVRDVCIPFDNPTRGYREKDRIVSFDSLNISLSPQPSSIALDGNGQPQIITARPPCAPIDLSSRSVLACGISSNDSDVRSIHPLSEHIAPISGLIEEIRSRVYSASQEQEENANDELFVPKNLNFEPVPSHENRERAMAIGVMGVPLTAEEALTLCTINQFRCKEGYLFDEDQNRKVASDDQALQDLWDWIERARKESSGTSMVVNGLDLNYLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W6QB58</accession>
    <name>W6QB58_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Arrestin C-terminal-like domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S02g001524</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QB58"/>
    <dbReference type="STRING" id="1365484.W6QB58"/>
    <dbReference type="OMA" id="PRIECQL"/>
    <dbReference type="OrthoDB" id="4001642at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000935">
        <property type="term" value="C:division septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000917">
        <property type="term" value="P:division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011022">
        <property type="entry name" value="Arrestin_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053060">
        <property type="entry name" value="Cytokinesis_Signaling_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36419">
        <property type="entry name" value="ARRESTIN FAMILY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36419:SF1">
        <property type="entry name" value="RHO1 GEF LOCALIZING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02752">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01017">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arrestin C-terminal-like" evidence="1">
        <location>
            <begin position="185"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM31374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="401" mass="44410" checksum="2E3073A8F133E15C" modified="2014-04-16" version="1">MAAFVRVSGPANGNFLIGYPGISATMPRIEGKVEIRPCAGITAPVNISLVTISLLRRETIHPSADTFTKKRLAPPRKEITDIVGKEMLLFRCPAGREYEEVISMDLPFVLFIPFGRGGRDASRRVPPASLQLPSRTAETYYEMVVMVQQGQQQQHKYTFPVPIARYDTLSTFGMYNRPESAERVSDHLVTLAISLPRWSYGPLDPVSVYVKLSPNESWMGKARKVTINKITIGIDEEIVYNHEGDEPQRKVKVLAKKTENIGVKLPQSGYLTNLGLVFPAKDLRDAEGILPRSRAAFPTYGVSGFTTTASLYKIEYYLTVRAHLTSARDITIRQPIVVCPLDHAGCKEEMEAIEQAARDAAHVNPDNPMLPLPAIVRPNDHNALSHLGAAIVGNQKKPLID</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2024-10-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>W6QB67</accession>
    <name>W6QB67_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S01g000761</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QB67"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM26952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="74" mass="8642" checksum="F039BB6A03CA708D" modified="2014-04-16" version="1">MPLRIDLDPFKCEILKPEAKFVRSEHLQTTLDLGEYRDLYDGNSFMTENCAAYFYDNLLPSKQSIRILKNALRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W6QBG1</accession>
    <name>W6QBG1_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peptidyl-prolyl cis-trans isomerase</fullName>
            <ecNumber evidence="6">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">pin4</name>
        <name evidence="9" type="ORF">PROQFM164_S03g000504</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PpiC/parvulin rotamase family. PIN4 subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="6"/>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QBG1"/>
    <dbReference type="STRING" id="1365484.W6QBG1"/>
    <dbReference type="OMA" id="NAINVRH"/>
    <dbReference type="OrthoDB" id="1911748at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043323">
        <property type="entry name" value="PIN4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000297">
        <property type="entry name" value="PPIase_PpiC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45995">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13616">
        <property type="entry name" value="Rotamase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50198">
        <property type="entry name" value="PPIC_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PpiC" evidence="8">
        <location>
            <begin position="35"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="13"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM33780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="129" mass="13793" checksum="766242CF16446E2C" modified="2014-04-16" version="1">MAPKNNAKAAKGKGKDASADDAKGKGGKGGAVKGAQSINVRHILCEKHAKKEEALEKLRNGTKFDEVAREFSEDKARQGGSLGWKTKGGLDPAFENVAFELETSTTGNPKYAEVKTGFGYHIIMVEGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>W6QBI5</accession>
    <name>W6QBI5_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">mrh4</name>
        <name evidence="11" type="ORF">PROQFM164_S01g000846</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QBI5"/>
    <dbReference type="STRING" id="1365484.W6QBI5"/>
    <dbReference type="OMA" id="HSTIDFI"/>
    <dbReference type="OrthoDB" id="10256233at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47960">
        <property type="entry name" value="DEAD-BOX ATP-DEPENDENT RNA HELICASE 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="195"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="461"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="46"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="96"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDM27037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="634" mass="71073" checksum="305C9FE4A449DC67" modified="2014-04-16" version="1">MPLPARSSICFLCQTKATLLAPSILPTSWQTTRGMATVRLRRKAARMALSPTVSKPSLPSPNKPRRERAGPFASMNQTQARIRDTPRTRSQAALKRSGEEGKMEKKESPLYRALKMQTTLTAVPYGRRSAIKARLADITSFDHFPLLPAVRQSIFGQALAGLTDVTPTPIQRLAIPELLLDESKKKKKVNKANEDEEEYNFDQYLLAAETGSGKTLAYLLPIVDAIKRAEVLDIEEEKVLEEQKAREREERMKNKAFDLDPEEPPMTNAARPRAIILVPTSELVSQVGSQLKELAHTVKYRSGEISSTFTPRRIKNTLFHPAGIDILVSTPHLLSSVARSNPNILSRVTHLVLDEADSLMDRSFIPTTSEIIAKVAPSLKKLILCSATIPRSLDNQLRKRFPDLQRLTTPNLHAIPRRVQLGVVDIEKEPYRGNRNLACADVIWSIGKAGDRHEHTETWGPLNAYMEPKVKKIIVFVNEREEADEVASFLQSKGIDAVSLSRDTDSRKQQETLSQFTEVKLPPTAEEIMINKKKNRAAGSIPFELPERQEPIRRLPDTKVLVTTDIASRGIDTLAVKTVILYHVPHTTIDFIHRLGRLGRMGKRGRGVVLVGKKDRKDVVREVREGMFRGQALI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>W6QC21</accession>
    <name>W6QC21_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Zinc finger, RING/FYVE/PHD-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PROQFM164_S02g001855</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QC21"/>
    <dbReference type="STRING" id="1365484.W6QC21"/>
    <dbReference type="OMA" id="IKCICSF"/>
    <dbReference type="OrthoDB" id="1928087at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070210">
        <property type="term" value="C:Rpd3L-Expanded complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034967">
        <property type="term" value="C:Set3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46462">
        <property type="entry name" value="UPSET, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46462:SF3">
        <property type="entry name" value="UPSET, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SET" evidence="6">
        <location>
            <begin position="276"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="89"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="454"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="813"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="870"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="24"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="89"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="99"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="118"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="462"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="493"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="521"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="537"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="550"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="576"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="588"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="813"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="877"/>
            <end position="888"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM31704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="943" mass="104745" checksum="625E2BB79BA9EF11" modified="2014-04-16" version="1">MTDTSSLAITHPTTDSYPVHAHRGSPAAVDGAASDSGAPDEEPYTIKCICSFDEDDGNTVFCEGCETWQHILCYYPDKKVPDVHNCVDCEPRPLDNRRAHERQRQRRIREKSEDGDRKARRSGPRTQKRKSNDADVNAFGHKRHDSGSREQPPSKRTKVSRGPSTSLSGISVPPGLSAEARNRRSSTSVAVSPTGIPGPPIPHYSEEFLSLYDRDDQFVESKSILNYGVDFVNEIVAWLKDPQILARVTDGLSVEDFAKRSEEAMDRSRWPSLVTETVTDSTIEIGGKHPVHKILKTKDPVQKDDVVGEIFGKLGHVKDYKKLHSNRWNELGHALPFVFFNRQLDLYIDSRQEGNELRHVRRSCEANVNLKIYITNGRQYHFCFVAKRDIPANTEITTMWYFDDSFFPSDATVKEEFKDRVVDPTDAAICISTTLANFGGCACGNPQTCVLNKLDRRAKPPPNKRSKSKLKGKTRKPKSLGLPADIGRAGSETTKHVDEHDPPADARSTSGSARGRHTGSSRDLSPTASQLTLPELSSRERRKIADAEKQFQQLEQVRNVNAKRKRRSNRPPTRFTPATQSSSTQTGEDFKPYHEFGPDRKTRQVTYVDAQTELYADDVERSFLRAERLRRGYKLDMIHPTLMHKIRWCAGHHIAEDLAQRNAWEAGDLSVVPSGVIPWWYGWFPLPIDDRSHIELLKEDSDRMGIPADHGPLAMPPRWSFHQSKYLQPEYNYHGIAIRGIHYDPPARPVQGDVDTRGALSYKRGSFASGSSSDLLKLSISPYWPSTAAHTLRIPGAGNRGYLRVSMPPPSNIPSVLSPGSMSTGSLASPSSRDTASPISLVPSSGSTLAGTPAKKKLSLGDYLIRRGTMTTTPTSEPAPAPPSGPPPDDSRLRTQHFLAITSVFGDNHQPPKTDPGDQNQSPDIIMTDAPEATPTKNPSISS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W6QC35</accession>
    <name>W6QC35_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="16">UDP-glucose:Glycoprotein Glucosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PROQFM164_S03g000739</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">FM164</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyltransferase 8 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1365484.W6QC35"/>
    <dbReference type="OMA" id="RQTKTRF"/>
    <dbReference type="OrthoDB" id="27683at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003980">
        <property type="term" value="F:UDP-glucose:glycoprotein glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018279">
        <property type="term" value="P:protein N-linked glycosylation via asparagine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06432">
        <property type="entry name" value="GT8_HUGT1_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000065">
        <property type="entry name" value="UDP-glucose:glycoprotein glucosyltransferase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040497">
        <property type="entry name" value="Glyco_transf_24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009448">
        <property type="entry name" value="UDP-g_GGtrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040693">
        <property type="entry name" value="UGGT_TRXL_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040694">
        <property type="entry name" value="UGGT_TRXL_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040692">
        <property type="entry name" value="UGGT_TRXL_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040525">
        <property type="entry name" value="UGGT_TRXL_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11226">
        <property type="entry name" value="UDP-GLUCOSE GLYCOPROTEIN:GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11226:SF0">
        <property type="entry name" value="UDP-GLUCOSE:GLYCOPROTEIN GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18404">
        <property type="entry name" value="Glyco_transf_24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18400">
        <property type="entry name" value="Thioredoxin_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18401">
        <property type="entry name" value="Thioredoxin_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18402">
        <property type="entry name" value="Thioredoxin_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18403">
        <property type="entry name" value="Thioredoxin_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06427">
        <property type="entry name" value="UDP-g_GGTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0732">Signal</keyword>
    <keyword evidence="5 16" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004879518" evidence="10">
        <location>
            <begin position="29"/>
            <end position="1479"/>
        </location>
    </feature>
    <feature type="domain" description="UGGT thioredoxin-like" evidence="11">
        <location>
            <begin position="43"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="UGGT thioredoxin-like" evidence="12">
        <location>
            <begin position="280"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="UGGT thioredoxin-like" evidence="13">
        <location>
            <begin position="414"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="domain" description="UDP-glucose:glycoprotein glucosyltransferase thioredoxin-like" evidence="14">
        <location>
            <begin position="671"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="domain" description="Glucosyltransferase 24 catalytic" evidence="15">
        <location>
            <begin position="1186"/>
            <end position="1452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="259"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF18400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF18401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF18402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF18403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF18404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CDM34015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="1479" mass="165528" checksum="9B9D2429FC3168BF" modified="2014-04-16" version="1">MRVPTGSHIPWQWYAVVGALLPGWVANASPAVNVALQASFDSAPYLVELLESAAEENSTAYFPLLDRIADGTFEDLTTEKELYDRFLTVVKDDGHIRTPEGLSSFKLSLSVRSSAPRIEAHFQFYNTSVQQSLMVAQDAVCPVWVHSEGKQYCSSTMERAQQDVVGELDPRELPFDRVLGDASLPSAVLYADITSPMFRDFHETLSDMAKQGQVSYRVRYRPPQHWISRPLFVSGYGVELALKRTDYIVIDDRDAEQLEEKGAQSLPTDPDETKEDAPGDLRPLSSSDVTRLGLNSAGYVMDSADPLGTLIKMSQNFPKYSSIVAAHNFTGEMAQEIRHNRLKMLPGGYNAMWINGVQMDKQQIDAFSLIEHLRRERKLIEKFRGLGLSADDVVKLLSHRLLTEAQASGEEQRYDYRDNLEGNQVIIWMNNLEKDSRYESWRGDIEGYIAGSYPGQLPPVSRDLHNVVVSMDSSNPEHMMLVAGNLHAFINRGIPVRFGLVPTISSPESIAQLKVAHYLSDAYGIESLVQYFQEYAAKGKMGFPDKSCFQSATRERDLVDEHEALSLDQVLKSEKYDAVVSQTGAYQRRLSLTGDAPQFLVNGIPVSREGNWMQGMSVQISKDLKLIQQGIVQGIFEEDTWLPEFFLADAFAKRNTFLMPEDPKSVQIVDIANILASDEDALSKTRVLSDKGALESTHMIVVGDFESEAGVKLLTDALNLRKENSDVEILMLHNAASDAEDDAPKNLATLYLSLAKEETIDQVLAKIASGNLETEVQDISTIQTLHQILAKELGFNPGTEGLVVNGRAVGPIEKEHPLSVGEMSQLIAYERVKRLDSVAAAVEELGFADKISNPLDFAKLTSLVALSTISDVPEGIFENTPDFRMDVSGKWRTEHSVITISNSDDPTIHVGVSLDPASEVAQRWSPILKVLSELSGVQLKIFLNPKEELTELPVKRFYRYVLESEPSFTDKGALARPQASFTGVPVEALLTLSMDVPSSWLVAPSESVYDLDNIKLSSVKSGTDVDAVYALEHILIEGHSRDLTTKTPPRGVQLILGTENNPYFADTIIMANLGYFQFKAQPGLWQINLKPGRSEKIFKIDSVGGLGYNPQSGDENNEVALLSFHGRTLFPRLSRKPGHEEDDVLETGVQLGSKMDYFAKGLNFASDVLSSVGVGSKSGGEQHADINIFSVASGHLYERMLNIMMVSVMRHTKHTVKFWFIEQFLSPSFRAFLPSLAREYGFSYEMVTYKWPHWLRAQKEKQREIWGYKILFLDVLFPLSLDKVIFVDADQIVRTDMYELVTHDLQEAPYGFTPMGDSRTEMEGFRFWKQGYWSTFLRGKPYHISALYVVDLNRFRALAAGDRLRGQYQMLSSDPNSLSNLDQDLPNHMQHHIPIHSLPQEWLWCETWCSDEDLGVAKTIDLCNNPLTKEPKLERARRQVPEWTVYDDEIAALASRVAGEQAAAGVEFVQTGEDRKDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>W6QCK9</accession>
    <name>W6QCK9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="21">Probable uroporphyrinogen-III C-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">PROQFM164_S02g002065</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Siroheme synthase involved in methionine biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>precorrin-2 + NAD(+) = sirohydrochlorin + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:15613"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58351"/>
            <dbReference type="ChEBI" id="CHEBI:58827"/>
            <dbReference type="EC" id="1.3.1.76"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>uroporphyrinogen III + 2 S-adenosyl-L-methionine = precorrin-2 + 2 S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32459"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57308"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:58827"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="2.1.1.107"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Porphyrin-containing compound metabolism; siroheme biosynthesis; sirohydrochlorin from precorrin-2: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 17">Belongs to the precorrin methyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QCK9"/>
    <dbReference type="STRING" id="1365484.W6QCK9"/>
    <dbReference type="OMA" id="TPCAIVE"/>
    <dbReference type="OrthoDB" id="508204at2759"/>
    <dbReference type="UniPathway" id="UPA00262">
        <property type="reaction ID" value="UER00222"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043115">
        <property type="term" value="F:precorrin-2 dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004851">
        <property type="term" value="F:uroporphyrin-III C-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019354">
        <property type="term" value="P:siroheme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000103">
        <property type="term" value="P:sulfate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11642">
        <property type="entry name" value="SUMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1010.10:FF:000006">
        <property type="entry name" value="Siroheme synthase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000504">
        <property type="entry name" value="Siroheme synthase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.950.10:FF:000005">
        <property type="entry name" value="Uroporphyrin-III c-methyltransferase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="entry name" value="Cobalt-precorrin-4 Transmethylase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="entry name" value="Methyltransferase, Cobalt-precorrin-4 Transmethylase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006366">
        <property type="entry name" value="CobA/CysG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012066">
        <property type="entry name" value="Met1_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028162">
        <property type="entry name" value="Met8_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050161">
        <property type="entry name" value="Siro_Cobalamin_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028281">
        <property type="entry name" value="Sirohaem_synthase_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006367">
        <property type="entry name" value="Sirohaem_synthase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003043">
        <property type="entry name" value="Uropor_MeTrfase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01470">
        <property type="entry name" value="cysG_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45790">
        <property type="entry name" value="SIROHEME SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45790:SF6">
        <property type="entry name" value="UROPORPHYRINOGEN-III C-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13241">
        <property type="entry name" value="NAD_binding_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14823">
        <property type="entry name" value="Sirohm_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14824">
        <property type="entry name" value="Sirohm_synth_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036555">
        <property type="entry name" value="SUMT_yeast"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75615">
        <property type="entry name" value="Siroheme synthase middle domains-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="Tetrapyrrole methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00840">
        <property type="entry name" value="SUMT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="11" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="4 17 21" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="13" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="9" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 17 21" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Siroheme synthase central" evidence="20">
        <location>
            <begin position="142"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="Siroheme biosynthesis protein Met8 C-terminal" evidence="19">
        <location>
            <begin position="227"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="Tetrapyrrole methylase" evidence="18">
        <location>
            <begin position="284"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00052360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00055636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU003960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF14823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF14824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="CDM31914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="566" mass="61728" checksum="3D2AC8787BDA7792" modified="2014-04-16" version="1">MKDASCDPSPTAPFMVAWNTDSQVHLIVGSNSLAAARCARSLEVGAKPIIIAPETDDMHFTLSEHIANGSAQWVRHGFQDEDLTTLGREEVDHVVDLVFVTLGSNNPLSSHISKLCRRLRIPVNISDAPELCSFTLLSTYSDGPLHIGITTSGRGCKLASRLRREIAAFLPQNLGTAIDRLGAVRRRLWEEDNAAGLVENIFDREDDDSTGQKHTFNNLVTEDDAAAAKTRRVRWLSQICEYWPLRKLVSITDADMDAILKAYTSGNATINDTNGVDTPSKKGKIVLAGSGPGHPDLLTRATYYAIHNADIILADKLVPAPVLDLIPRRTEVHIARKFPGNADQAQEEFLMMGLAALKQGRQVLRLKQGDPYLYGRGAEEFEFFRKEGYSPVVLPGITSAMSASLFADIPATHRGVSDQVLVCTGTGRKGAAPNPPTYVPTQTVVFLMALHRLSALVESLTTFPAEDAGSQSRKLWPKETPCAIVERASCPDQRVIRSTLEHVCLAFEEAGSRPPGLLVVGASCHVLHNPQGQRWVIEEGFHGLDDIRNEVAAQVDAVAVSVNEKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W6QCS1</accession>
    <name>W6QCS1_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S03</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S03g000585</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1365484.W6QCS1"/>
    <dbReference type="OMA" id="AFEHTFP"/>
    <dbReference type="OrthoDB" id="20105at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="274"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="318"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM33861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="381" mass="43096" checksum="63DA9C4C2AF70C3E" modified="2014-04-16" version="1">MKPTSEPPKRTNGNNDLHEATKTKTQCLPSYLIPRPSIEDQPTNPNHAMSSRRYLVLPPEINRLPPQPMTTSLHPQPAGWEDRKMWLHAKIEEERRRQEEEKTHRAKVVLEQRRIEQSILSDALDAGVPPNMVPLIFNGIYTTGANLQLAAELQRQWSAPSAMPQPQNNPGPASSARLPVAPQPPQQGPRQPPRAQASELPPTVSNHLQETRHTWWSEAMSNSHRARVINSEREQLRRKLIAQNVEFADKDLLDTAFEHTFPVTSSMVQAHTSRYWASPSDKTSRSQEKRQQAPQKAHPMVSQESGRLQLINIASVTNVPSHVHPEQTNSLSPKRKDQRSHEKVPPPKHRQNETLCCEQDLSDAVHVSSPVEDTIVSIKLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2024-10-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>W6QD15</accession>
    <name>W6QD15_PENRF</name>
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        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">PROQFM164_S01g001308</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QD15"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM27497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="58" mass="6572" checksum="B8386587C47E91A8" modified="2014-04-16" version="1">MRQLIFNTRFLSQSIFPRFCPSDSIRDIFDHASNMAGLRSGCRSATGPCRVEWNHSGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W6QDP2</accession>
    <name>W6QDP2_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">acylphosphatase</fullName>
            <ecNumber evidence="1">3.6.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">acyP</name>
        <name evidence="4" type="ORF">PROQFM164_S03g001334</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>an acyl phosphate + H2O = a carboxylate + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:59918"/>
            <dbReference type="EC" id="3.6.1.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acylphosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.7" evidence="1"/>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QDP2"/>
    <dbReference type="STRING" id="1365484.W6QDP2"/>
    <dbReference type="OMA" id="VGFRWSM"/>
    <dbReference type="OrthoDB" id="7961613at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003998">
        <property type="term" value="F:acylphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020456">
        <property type="entry name" value="Acylphosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001792">
        <property type="entry name" value="Acylphosphatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036046">
        <property type="entry name" value="Acylphosphatase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47268">
        <property type="entry name" value="ACYLPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47268:SF4">
        <property type="entry name" value="ACYLPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00708">
        <property type="entry name" value="Acylphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54975">
        <property type="entry name" value="Acylphosphatase/BLUF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51160">
        <property type="entry name" value="ACYLPHOSPHATASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acylphosphatase-like" evidence="3">
        <location>
            <begin position="8"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="24"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM34610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="106" mass="12238" checksum="BE8677739C46966A" modified="2014-04-16" version="1">MSHMPQTRIAFKVHGTVQAIAYYRDFTQKCANLDELNGWVRNTTCGRVEGEAQSSDEKVQRFLQRIQKGPSRALVVKLEKRELDVRDDEEGFVVMRTADSMFEARD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>W6QEE4</accession>
    <name>W6QEE4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S03</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S03g001120</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QEE4"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM34396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="37" mass="3929" checksum="CDB748358A0A6369" modified="2014-04-16" version="1">MSTNSASTLPRGPEIGRDLWIGPAKTGLFQILLACGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W6QEX1</accession>
    <name>W6QEX1_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein kinase-like domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g001948</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QEX1"/>
    <dbReference type="OrthoDB" id="4177236at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF48">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="51"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM28137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="275" mass="31421" checksum="38EF25363E6945B4" modified="2014-04-16" version="1">MHSMDSNIDLPTVAEIEASTDILSIRTNSIKVVRLRERFAVKIGYAIPPVEAENIKFVAANSMVSVPKVYANFVDPENQKRYIIMDFIPGAGLQKLHPSLIPAEKTVSKRIKETFDELRAIPSPVGNLNGMPYLDGVLATPDNNPVISGPFTNQEQMNQGILKRLGQTQSPHHTRLVQGMADRTLKDHRIVFTHGDLQRKNVMVERTVNNNGDADFKVTLIDWNLSGWYPEFWDFCNSTIYCQRKPDWVELIPDIFDQYPLEYLMMQLVYSMVFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W6QFC0</accession>
    <name>W6QFC0_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Rhamnogalacturonan acetylesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rha1</name>
        <name evidence="4" type="ORF">PROQFM164_S01g002068</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 'GDSL' lipolytic enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QFC0"/>
    <dbReference type="OMA" id="QMGHNDA"/>
    <dbReference type="OrthoDB" id="2141316at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001087">
        <property type="entry name" value="GDSL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037459">
        <property type="entry name" value="RhgT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43695">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_2G17250)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43695:SF1">
        <property type="entry name" value="RHAMNOGALACTURONAN ACETYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00657">
        <property type="entry name" value="Lipase_GDSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004881992" evidence="3">
        <location>
            <begin position="17"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM28257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="250" mass="25747" checksum="2EDEC7450F174F76" modified="2014-04-16" version="1">MKSAILLSAVIPSALGATIYLAGDSTMAKGGTGSGTAGWGEYVTPYTSLTVSNQAVAGRSARSYTREGRFDAIAAVVQSGDWVIIEFGHNDGGSLTPTDNGRTDCSGTGSETCSTTYDGVAETVLTFPAYVENATKVFKAKGANVIISSQTPNNPWETGTFTYAPSRFVGYAQVAAAAAGVPYVDHGAYVADQFQTLGLTAVDAYFPLDHTHTSPTGASVVAQAFFKAVVCGDVALKSSLTTTSFPGSCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W6QFP9</accession>
    <name>W6QFP9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Atg6p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PROQFM164_S02g003160</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the beclin family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM33009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QFP9"/>
    <dbReference type="STRING" id="1365484.W6QFP9"/>
    <dbReference type="OMA" id="EWDVYKA"/>
    <dbReference type="OrthoDB" id="20368at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034271">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034272">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043548">
        <property type="term" value="F:phosphatidylinositol 3-kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006995">
        <property type="term" value="P:cellular response to nitrogen starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045324">
        <property type="term" value="P:late endosome to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.40:FF:000005">
        <property type="entry name" value="Autophagy protein Apg6, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.40">
        <property type="entry name" value="Autophagy protein 6/Beclin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007243">
        <property type="entry name" value="Atg6/Beclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038274">
        <property type="entry name" value="Atg6/Beclin_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041691">
        <property type="entry name" value="Atg6/beclin_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040455">
        <property type="entry name" value="Atg6_BARA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12768">
        <property type="entry name" value="BECLIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12768:SF4">
        <property type="entry name" value="BECLIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04111">
        <property type="entry name" value="APG6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17675">
        <property type="entry name" value="APG6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Atg6/beclin coiled-coil" evidence="5">
        <location>
            <begin position="150"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="Atg6 BARA" evidence="4">
        <location>
            <begin position="281"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="29"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="215"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="49"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="109"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDM33009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="515" mass="56699" checksum="DB5500ECCD2502EF" modified="2014-04-16" version="1">MYCQKCRTPLKLDGSVESLNPAAFDLLSNSTGKTLSDTGAVSSSARSSYPHERRDKYDQSSKHATSPVYRRSIPAPRAGQPNPVPRADSGNMSFVMLTESQVAPPPVSESGSKRNTQAQLHDQDGPLVDQVEKTTRLFEIVSARSDIDHPICVECTELLVEGLQKRLAGSTKERDAYISFLRNLNASIPTEEEVQAAQKSLNESLDAERAAFAELQAFEKEKAALDAEIASLEIESRRLDADEESFWRSRNAFALTLTEFQNERDALNMRYDHDSQQLERLQRTNVYNDAFCIGHDGYFGTINGLRLGRLANPSVDWPEINAAWGQTALLLATMAEKLGFQFQGYRLKPLGSNSRIDKIEYPTQPAGQPVEGAAPKVTQLDLFSSGDLPLNLPWLHRRFDSGMVAFLECLRQLGKFVEKTPAPVVSPRRGQTGATAPGLKLPYEIKRDRIGDASIKLGFNQNDETWTRACKYTLTCCKFLLAHASNLASTGSNSAAVAAAAVAAADQARQTKNKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>W6QFU1</accession>
    <name>W6QFU1_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">COP9 signalosome complex subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">csnD</name>
        <name evidence="10" type="ORF">PROQFM164_S02g003210</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM164</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4">Component of the COP9 signalosome (CSN) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CSN4 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM33059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QFU1"/>
    <dbReference type="STRING" id="1365484.W6QFU1"/>
    <dbReference type="OMA" id="KNIMHTV"/>
    <dbReference type="OrthoDB" id="295656at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000190">
        <property type="entry name" value="COP9 signalosome complex subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054559">
        <property type="entry name" value="PSMD12-CSN4-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040134">
        <property type="entry name" value="PSMD12/CSN4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10855">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 12/COP9 SIGNALOSOME COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10855:SF2">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22241">
        <property type="entry name" value="PSMD12-CSN4_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0736">Signalosome</keyword>
    <feature type="domain" description="PCI" evidence="9">
        <location>
            <begin position="194"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDM33059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="422" mass="46430" checksum="1B88955D201B56DD" modified="2014-04-16" version="1">MASQKMTNALAGIETNPHQPTKLQQYTELLNEMVATSSGHELAQDLVYYLDSILSEEVSIVAARPLLDAFITVLQSLDPETKIKVGQHAITLLHTRSASVEEQDSQIREILADAYESQEDYTAAARTLQGIHIDSSQRLVSDAAKARLWIRIVRYYLEDDDTTNAEAFLNRIKNLPSKIEDHDAKLYFQLSQARILDARRRFLDAAQEYFNVSLAPGVDEEDRLTALSAAIRCAVLAPAGPQRSRSLARLYKDDRTPSVEEFGILEKMFLDRLLTADEVAAFAKKLAPHQLAVTADGTTVLDKAVIEHNLVAASKLYENIHVDDLGSILGLQSSGDVSAGEKAEAYAARMVEQGRLRGRIDQIDGVISFDADTLGGSSAGASNGTKLRQWDLGVQDLAEDVERVATSISDQFPEFATSQMVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W6QGB1</accession>
    <name>W6QGB1_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Signal recognition particle 54 kDa protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">srpA</name>
        <name evidence="15" type="ORF">PROQFM164_S04g000724</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Signal-recognition-particle (SRP) assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum (ER) membrane. SRP is required for the cotranslational protein translocation for ER import and preferentially recognizes strongly hydrophobic signal sequences. It is involved in targeting the nascent chain-ribosome (RNC) complex to the ER and is proposed to participate in the arrest of nascent chain elongation during membrane targeting. SRP54 binds to the signal sequence of presecretory protein when they emerge from the ribosomes. SRP54 interacts with the scR1 RNA and mediates the association of the resulting SRP-RNC complex with the signal recognition particle receptor (SR) via its alpha subunit SRP101. Both, SRP54 and SRP101, are locked in their GTP bound forms in the SRP-RNC-SR complex, which dissociates upon transferring the signal sequence to the protein-conducting channel (translocon). After signal sequence transfer, SRP54 and SRP101 act as reciprocal GTPase-activating proteins (GAPs), thereby resolving their association.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.4"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="13">Fungal signal recognition particle consists of a 7S RNA molecule (scR1) and at least six protein subunits: srp72, srp68, srp54, sec65, srp21 and srp14.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 13">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="13">The M domain binds the 7SL RNA and the signal sequence of presecretory proteins.</text>
    </comment>
    <comment type="domain">
        <text evidence="13">The NG domain, also named G domain, is a special guanosine triphosphatase (GTPase) domain, which binds GTP and forms a guanosine 5'-triphosphate (GTP)-dependent complex with a homologous NG domain in the SRP receptor subunit srp101. The two NG domains undergo cooperative rearrangements upon their assembly, which culminate in the reciprocal activation of the GTPase activity of one another. SRP receptor compaction upon binding with cargo-loaded SRP and GTPase rearrangement drive SRP-mediated cotranslational protein translocation into the ER.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the GTP-binding SRP family. SRP54 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QGB1"/>
    <dbReference type="STRING" id="1365484.W6QGB1"/>
    <dbReference type="OMA" id="GMTGQDA"/>
    <dbReference type="OrthoDB" id="10250817at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030942">
        <property type="term" value="F:endoplasmic reticulum signal peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006616">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane, translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17875">
        <property type="entry name" value="SRP54_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.260.30:FF:000003">
        <property type="entry name" value="Signal recognition particle 54 kDa protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000022">
        <property type="entry name" value="Signal recognition particle 54 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.140:FF:000001">
        <property type="entry name" value="Signal recognition particle GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.140">
        <property type="entry name" value="Signal recognition particle SRP54, nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.30">
        <property type="entry name" value="Signal recognition particle, SRP54 subunit, M-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00306">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036891">
        <property type="entry name" value="Signal_recog_part_SRP54_M_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013822">
        <property type="entry name" value="Signal_recog_particl_SRP54_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004125">
        <property type="entry name" value="Signal_recog_particle_SRP54_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022941">
        <property type="entry name" value="SRP54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006325">
        <property type="entry name" value="SRP54_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042101">
        <property type="entry name" value="SRP54_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01425">
        <property type="entry name" value="SRP54_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11564">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 54K PROTEIN SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11564:SF5">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE SUBUNIT SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02881">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02978">
        <property type="entry name" value="SRP_SPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00962">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00963">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47446">
        <property type="entry name" value="Signal peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00300">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 13" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 13" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 13" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="8 13" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="10 13" id="KW-0733">Signal recognition particle</keyword>
    <feature type="domain" description="SRP54-type proteins GTP-binding" evidence="14">
        <location>
            <begin position="269"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU364034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS00300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CDM35843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="522" mass="56057" checksum="D4802ECB9E9828F9" modified="2014-04-16" version="1">MVLQDLGRRINSAVNDLTRSSNLDEKAFDDMLKEICAALLSADVNVRLVGTLRKSIKASVNFASLPAAVNKKRLIQKTVFDELVKLVDPRADSFRPKKGRSNVIMFVGLQGAGKTTTCTKLARHYQTRGFKTALVCADTFRAGAFDQLKQNATKAKIPYYGSLTQTDPAVVAAEGVAKFKKERFDIIIVDTSGRHRQEEELFTEMTQIQNAVTPDQTILVLDSTIGQSAEAQSAAFKATADFGAIIITKTDGHAAGGGAISAVAATHTPIIFLGTGEHMMDLERFEPRAFVQKLLGMGDVAGLVEHVQAMTKDSAGAKETYKHIAEGIYTLRDFRENITSIMKMGPLSKLSGMIPGLSNMTQGLDDEDGSLKLRRMVYIFDSMTVAELDGDGKNFVEQPSRMVRIAHGSGTSVREVEDVLSQHRMMAGMAKRVGGQKKQMQQAQNMMKGGNKNQQMAAMQKRMASMGGAGGGGMPGMPDMAKMMQMMGGGGGGMPDMQSLMSQMGGLMGGMGGGGGGRGRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W6QHC7</accession>
    <name>W6QHC7_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g002833</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QHC7"/>
    <dbReference type="OMA" id="GEWEGFM"/>
    <dbReference type="OrthoDB" id="4340895at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="270"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="374"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="206"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="390"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM29022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="666" mass="74034" checksum="38502D2A8BA641A0" modified="2014-04-16" version="1">MPLTLSLLYNLPLFNDSALYSPVGDYLNSQIKNVCQEYTNKIRLAGPESSVSCNQIKPSHDLLLSTQPSMCVQCESEWADNVSQEDDQTQTAKSYRTIEGLDATGHVIEVSARMLCSRAVVSESESDYGSLARSERSSSTAFKLARTNSGSSEIAADPDSFASITIKTSPAHLAHSGCESDYSKESVETESPDTEGTGCATPSNVSSCDTDSSGSSLCGSSLIRYNILKLRIDEYFEKRQRRREVDTDHQQPEADDSGVDVRIYLADVDHPHPALGDRPPADSVDSPEVDYDSSEESALDIDLVQQRIEATVLKCIEENDEKKAREKAMSKLLDTALLKKDRDDRREKNAELGIEEDPHIWDTESLVQMWEAKNSIPAPPDDTSIAISPRNCTSPKSQQAPPGPDPRPQKHMYMGSMFASEESAYQRGLREIRPYGDYSGEWEGFMMADSEDDANRQGLLDPIHVRGCCAERRADFHLYYGVMHAPSEVEAEKRWLEDIRRIPGEDGKFYGLLRADDLHHARAMGLSDIRHPWGCCKDAHFTMPERVRHRYTGFMSAISLKEVGHMGLCDAAPVPGECDAFQMGLKDPEHDRDCCAKAEVSVSISEAGQYTYYGYMYARSEEEVVDRGLKDALLVPGFEIKYSGNLQAGSEEEAKAMGLFEPSRIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W6QHP9</accession>
    <name>W6QHP9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S04g000402</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QHP9"/>
    <dbReference type="OMA" id="SHRSWTY"/>
    <dbReference type="OrthoDB" id="3056235at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM35521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="144" mass="16612" checksum="678623626872FC04" modified="2014-04-16" version="1">MSRPPPQQCGNSTSERPYIESVPRTQHRGPIPMPYPYRHEPRQTIPQSTSYEHPMHGAPLGPRLPALIVPERNADPRYMLSSDIAYLNTQHMSQTLPLRSHHQPPGSSDARGYYNPYEERTYPSSSHARDYDSHRSWTYDVESQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W6QHS1</accession>
    <name>W6QHS1_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Bladder cancer-related BC10-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PROQFM164_S04g000427</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QHS1"/>
    <dbReference type="OMA" id="CMDIYIR"/>
    <dbReference type="OrthoDB" id="5563033at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009598">
        <property type="entry name" value="BCALP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13259">
        <property type="entry name" value="BLADDER CANCER 10 KD PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13259:SF1">
        <property type="entry name" value="BLADDER CANCER-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06726">
        <property type="entry name" value="BC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01396">
        <property type="entry name" value="BC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDM35546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="161" mass="18175" checksum="A7770941F77CB7ED" modified="2014-04-16" version="1">MFCLRSWLPLLFIPTNASPLFIISFVALTYIIHRPCIYCSALLLILFVSSCHWSDRCIFDLRSNWFAPRYTSEPSNYAISGNATYEATVSGEGLTEFVFDTMNSTAKVLAGAVLEGVQQRISPNGMESRPTEWTGVGLEWVRSLLGRREWTLPCVDVKVRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W6QIJ8</accession>
    <name>W6QIJ8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S05g000476</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QIJ8"/>
    <dbReference type="STRING" id="1365484.W6QIJ8"/>
    <dbReference type="OMA" id="KERYNQI"/>
    <dbReference type="OrthoDB" id="4357552at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM36643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="357" mass="41688" checksum="EFF7D5096387A01C" modified="2014-04-16" version="1">MDSKTPQISPALETLPFEIRRHILSMVEIDSLKTLVRASPVYFHHYQLERKLLLFHKSTSMECSKGRDSKGIDDFLTSYHTMRSQAWLSPFHNILIMEEVETMIEETPSTTEETKLMRGFYRFQLCCNIYGLESAESIPYVSWISISQRILGDFLCIFDPWEAEEISCVSYFCEEKCEQIFDQTKQGLDEENSGIDQPDISDIASPSKLTRNRGLELLHLVYPIKDQDHLVVTRQLPPPMRPSGVLSDLHSVFEQHLQWHRHCVHPGERDHRQERREPLIFQCDRKPDGSCALPPLAWTIIWGGSYSNLFGEYIPDASCEWAWVMWDADRLKRMSALGVIIQEWEKEHHDDPRKDYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W6QIR4</accession>
    <name>W6QIR4_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Altered inheritance of mitochondria protein 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S04g000772</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AIM6 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QIR4"/>
    <dbReference type="STRING" id="1365484.W6QIR4"/>
    <dbReference type="OMA" id="QRVRFWA"/>
    <dbReference type="OrthoDB" id="4153866at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051236">
        <property type="entry name" value="HAT_RTT109-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31571">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31571:SF5">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004881656" description="Altered inheritance of mitochondria protein 6" evidence="2">
        <location>
            <begin position="26"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM35891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="318" mass="35145" checksum="84E23A218C731978" modified="2014-04-16" version="1">MPSAFMLFLSSVAVALLAGPDPALGAITSSLQSILKNTHGSPDYRYPTDLTRDLLPIPVHSHNDYWRDEPFYTGLSHGCTSTEADVWLYNGTLYVGHDESALTESRTLESLYINPILDVLERQNPESPFISSPTKNGVWDTVPDQTLYFFIDVKTSGPETFQAVIAALEPLREKGYLTTVKDGKTVTNGPVTIIGTGETPFDMVAPIKDRDYFFDAPLADLNDPKYADITGVISPVASTNFREAVGKITVDTDPILSDDQLKALRDQISTANERGIGARYWNTPHFPIRARNLVWRTLLREGVILLNADDLDAVASYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W6QIZ2</accession>
    <name>W6QIZ2_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S04</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S04g000867</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QIZ2"/>
    <dbReference type="STRING" id="1365484.W6QIZ2"/>
    <dbReference type="OMA" id="YYDNQQW"/>
    <dbReference type="OrthoDB" id="5401193at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="239"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="279"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="316"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="358"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="389"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM35986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="407" mass="42472" checksum="9A641DC945D890E5" modified="2014-04-16" version="1">MSSYYEPQGWQAPAARQVSWEQPAPPSRSGSSSVSQREDLPAFSSQFDEVDRAIDNLVKSGKLWNAPRRDSMPMMMGRPYPDYDPRMGGGPQRHHSISEFDGNRMPPAGNAQGFYASQRYQGRPNEVEQMMQAKRRMAAQRERELRNYHQEQQYNRSLLAEMSASKSDRSTSPAAVSEDSRRELLARQHRALYGNESPAFFPPGAFSDDNPRPDSQAGGGTPSSAGVRGSSPRGMDPFGLTQAGATGTDATTGLQSPSRANSTSSPSSAINASFGGEQPVTSASSPGADSPSRQASSKPAGPIGTVGPIGSRPAPGQTSAPPANQALNKRSITPLPSPLGLGFTPADPTAGPATERTSSAGPSPAVASAAGAPGTKDQAGGVGLGWSNGSGVWSSKSGLGVQASVWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W6QK33</accession>
    <name>W6QK33_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S05g000578</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1365484.W6QK33"/>
    <dbReference type="OMA" id="KYMGVPR"/>
    <dbReference type="OrthoDB" id="5367052at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="727"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="774"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="841"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1019"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="963"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="30"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="65"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="149"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="163"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="292"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="317"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="334"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="347"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="446"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="509"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="533"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="571"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="797"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1019"/>
            <end position="1030"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM36745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="1299" mass="144440" checksum="22089E1C5C9F8497" modified="2014-04-16" version="1">MDAQPNMNSWLGPNHAGVEQPLSNHYPGWSSTAASPSNQSSPRREHAVQPPLLTTALSGPQYQGLGLTPTPSSSTSLSSPFTHSLSPAVPSPVNSRSVSLSSMASRNAYNVPYNPQDWGPPGRPQSQAPYLQPGAMHRVTPQRNNPDVPLSPPPPPYSPPSNQNRTSPDFSGQPNSNFAGTPSPPDNRAGGFDMPVQYQRRSNRPRPLSMAYPSDLGSQRQSLPPPPPPQGHPASRSVSQGRVEYHGMPYNDQTQYNAAASLRPRLAQYDQGQPSPGFNEQMPLTPAHFETPSRAPGSRRAASAGAVVSSAGSSRATSQSRNRSPSNSTWEPGMPLPPPPPGPPPAARSVSVSGSSESSLRTPQSSNRTTRRGPPVLGTGLGSIPPTPADWIDEGYLNSRPTENLYVDTAKAAKAPEPTDGDPHDSSNQRTPGSGGLFRSPAVRDPSAKGIRERRIERRNRQSQVFEPPSAVSSNGNPWADALEQIKPSNLILPEQTSSPGQDRHPTSGKYNQTPGSTRSIKSEGQHFATRPRASSSAVVTEQSPYTTPRQLPSSAGPSTAFAHTPPFSPNPNGLGSSTYPKEATQAVPPKALPTPPLNSAKEVRPRSRSRAPSRGPEDRPISHILHMPNDAVSIMKPLSARRTPGQQTTQVSMESILRQDPAFLQDAIQRHEIFIDKEASAEDDTEALKIFADYMLAESQIRRQRYAKVWESFQVEDVRRNLFELPVKQPPKPKPKPQPKLDIPQNRAGRPESAWWNNYQPCLSPIASLNMSNEESSRGRAPSRWWESATGSSGEGGERRVQRSKRESKYMGLPREAMLGDQELTPSQPKDVSMNYATTEYGSDEYPPEKVSWPEDSPRNSIETGYREESRNLDISRLITLPPPYPRHHPAVNNSHPDLVTHRTTVRSITDLAEIKTTRHRYKADVERMLQEHQQQVDEGHRHFRSNIQSQIQEGSLTFAEAAEAEAAMIAEENERERIMVKRQLDTYQETVLKPMHAILVDRINRATTCIDQLSSMLSDDAQSGTPDQTQEEGDEKPELLEKLTQLKWLFEAREQLHRESFDLISDRDDKYKAVALLPYKQTKNEDKLRETQAFFTQDALDRRVQYETEALTRLETFLDVIEQNVMRGVEVQLSAFWDIAPSLLALVQQAPEDLHGFRVQIPADEYEENPSYHEHPLQYLYTLLSHAEKSSYQFIESQTNLLCLLHEVRSAVMRANQKLVEAQRIKRGEAEEDVRREMQETSADEELALTTDLKDKVATVEGQWTEALGSQIEGLRERVKEQLMSEDGWEELEQLEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W6QKA9</accession>
    <name>W6QKA9_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF3752 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S02g000166</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QKA9"/>
    <dbReference type="OMA" id="NKAADFG"/>
    <dbReference type="OrthoDB" id="73491at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022226">
        <property type="entry name" value="DUF3752"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046331">
        <property type="entry name" value="GPAM1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46370">
        <property type="entry name" value="GPALPP MOTIFS-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46370:SF1">
        <property type="entry name" value="GPALPP MOTIFS-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12572">
        <property type="entry name" value="DUF3752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3752" evidence="2">
        <location>
            <begin position="102"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM30017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="247" mass="27448" checksum="48FC82090D67FCD1" modified="2014-04-16" version="1">MSSTAMESTDKRKFDETTDDSQPGSVAKQRKVIGPSLPPPQEADAASETSRDDDDDDDDDFGPSLPPSGPVSSVRQESTAPDISKSAEKEKENQRDQWMLQPPSHSDWSSKVDPTQLRSRKFNTGKSATASKDLDSSWVETPEERMRRLQDAVMGVAASKKQPGDYKGPSNAKMMEDQIKKYKEMTGKTTRLETQAQAPEEEDDPSARAFDREKDMAVASKISSAQRREMVKKAADYNTRFTKGSFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W6QKF0</accession>
    <name>W6QKF0_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S06g000224</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792020">
        <property type="protein sequence ID" value="CDM37263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QKF0"/>
    <dbReference type="STRING" id="1365484.W6QKF0"/>
    <dbReference type="OMA" id="NEWAVNT"/>
    <dbReference type="OrthoDB" id="3531591at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM37263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="582" mass="65332" checksum="6D7E5BCF722EEF53" modified="2014-04-16" version="1">MDKAILGLTAQKIRELFTICGIEDSEEHLNLVIAHAADHVYKARLVIARGATEPISQAKEATIETPPTPPHDTRGSYRLMKRTGKEGPTTYSDMASTEKKKKKRRKRSHRSELIDQPPGSSVADGNGTAKDKAPEESISPEVQTTSEVDDPESVPDPLDSSLPLHLNSAFEMKVITTILIQCVKYNSDIAQYGQRDCMALATTKLERMREHAQEFSGYSYEQAIHAIRRDTALTTGRAIQTRYNETIFWPIILKCAALIDPATLPPVKGPADGFTMAEKAATKKFMEDTGYSLGAENQRQYRIFWKNIFHMREAGIEKILFYRTKEFDSFCRGYSKTSETPLVDKVLRWENEYLPHFEQLETRITKLKTGDSKRLSYLTNPQVLERLKVPELSWDNASNEWAVNTEEESFRQCGSVSISTDILGIPHNDESVYEGGTDKSAFITLLPKDDDSLFVSSIVPICEGDFLGIFAGTIRFSEDFNVTHGISGPAESLWLDYSQVTGALNQMQVSEPGGYANVCLRWAIFHDDTATEPRVSWRVSVKATKHIMPFHPIVRAAARQEQYHLHLSPGNAKRGFLESATN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W6QKG2</accession>
    <name>W6QKG2_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">COX assembly mitochondrial protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PROQFM164_S03g001434</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for mitochondrial cytochrome c oxidase (COX) assembly and respiration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the CMC family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QKG2"/>
    <dbReference type="STRING" id="1365484.W6QKG2"/>
    <dbReference type="OMA" id="WWGLPED"/>
    <dbReference type="OrthoDB" id="6224010at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013892">
        <property type="entry name" value="Cyt_c_biogenesis_Cmc1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22977">
        <property type="entry name" value="COX ASSEMBLY MITOCHONDRIAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22977:SF5">
        <property type="entry name" value="COX ASSEMBLY MITOCHONDRIAL PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08583">
        <property type="entry name" value="Cmc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU364104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDM34709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="137" mass="15888" checksum="AAFE8C8ADF252D39" modified="2014-04-16" version="1">MATSSTSPDTSSTSAPKKYNLRNPLPLSAPQEQEVKLLYYKRVRAHCAPEIKAFAECAVNRTVTATWVCRQQRLAMNSCMVAHAKPEEEDRAREEWFAGYEERRRAREDDLARVEKRRAEVIRMMREDEARTRAAEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W6QKJ8</accession>
    <name>W6QKJ8_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S06g000289</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792020">
        <property type="protein sequence ID" value="CDM37328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QKJ8"/>
    <dbReference type="STRING" id="1365484.W6QKJ8"/>
    <dbReference type="OMA" id="DAYGDKD"/>
    <dbReference type="OrthoDB" id="4338954at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM37328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="93" mass="10619" checksum="55483A7871118B8E" modified="2014-04-16" version="1">MLSQFALPGANKPYGNPTRTTFKPRNGRLLIPFMATIGLGFGAYNYYVAAKLRREQALLEEEQRLARNQQLMDAYGDKNSLHELQHALDTYSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>W6QKY5</accession>
    <name>W6QKY5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="14">ATPase WRNIP1 homolog C26H5.02c</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PROQFM164_S05g000494</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Functions as a modulator for initiation or reinitiation events during DNA polymerase delta-mediated DNA synthesis. Has an intrinsic ATPase activity that functions as a sensor of DNA damage or of arrested replication forks and regulates the extent of DNA synthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family. RarA/MGS1/WRNIP1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QKY5"/>
    <dbReference type="STRING" id="1365484.W6QKY5"/>
    <dbReference type="OMA" id="RIILSQC"/>
    <dbReference type="OrthoDB" id="10265467at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008047">
        <property type="term" value="F:enzyme activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000731">
        <property type="term" value="P:DNA synthesis involved in DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18139">
        <property type="entry name" value="HLD_clamp_RarA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3710.10:FF:000005">
        <property type="entry name" value="AAA family ATPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.272.10:FF:000001">
        <property type="entry name" value="Putative AAA family ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000029">
        <property type="entry name" value="Replication-associated recombination protein A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000137">
        <property type="entry name" value="Replication-associated recombination protein A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3710.10">
        <property type="entry name" value="DNA polymerase III clamp loader subunits, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032423">
        <property type="entry name" value="AAA_assoc_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051314">
        <property type="entry name" value="AAA_ATPase_RarA/MGS1/WRNIP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021886">
        <property type="entry name" value="MgsA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006642">
        <property type="entry name" value="Rad18_UBZ4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13779:SF7">
        <property type="entry name" value="ATPASE WRNIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13779">
        <property type="entry name" value="WERNER HELICASE-INTERACTING PROTEIN 1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16193">
        <property type="entry name" value="AAA_assoc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12002">
        <property type="entry name" value="MgsA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00734">
        <property type="entry name" value="ZnF_Rad18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBZ4-type" evidence="13">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="12">
        <location>
            <begin position="156"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="25"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="29"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="84"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00056113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDM36661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="539" mass="59112" checksum="2227BB50CCE85F74" modified="2014-04-16" version="1">MVSCPICDQSVSQLKINNHIDSGCQSFIEEPSSSPGEPASSQKGPVPSMFQPPSARKASAQSSIPKVSPSRPTTTPRALTGKRSFTEEAESTRERDVLKQPNGESKEPQAKRPRINAFHKAAPLAERMRPKTLDEVCGQELVGPNGILRGLIEQDRVPSMILWGSAGTGKTTIARVISSLVGSRFVEINSTSSGVAECKKIFAEARSELGLTGRKTIIFCDEIHRFSKSQQDVFLGPVESGQVTLIGATTENPSFKVQNALLSRCRTFTLAKLTDEDITSILHRALRVEGPNYSPSELVDEELVQYLAKFSDGDARTSLNLLELAMDLSKRPGMDKEDLKRSLTKTLVYDRAGDQHYDTISAFHKSIRGSNPDAALYYLARMIQSGEDPLYISRRLIVVASEDIGLADNTMLSLAISTHSAVEKIGLPEARINLAHATVAMALSKKSTRAYRGLNNVFAALNEPGIAGLPIPVHLRNAPTKLMKELGYGAEYKYNPNYVDGKVQQDYLPEQLLGRTFLEDLDLGTRRDSDLDSTSYQRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W6QL10</accession>
    <name>W6QL10_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cohesin loading factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PROQFM164_S06g000485</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SCC4/mau-2 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792020">
        <property type="protein sequence ID" value="CDM37523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QL10"/>
    <dbReference type="STRING" id="1365484.W6QL10"/>
    <dbReference type="OMA" id="QMVDICC"/>
    <dbReference type="OrthoDB" id="5565328at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019440">
        <property type="entry name" value="MAU2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21394">
        <property type="entry name" value="MAU2 CHROMATID COHESION FACTOR HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10345">
        <property type="entry name" value="Cohesin_load"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="4" id="KW-0498">Mitosis</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="269"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="910"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="52"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="82"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="103"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="125"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="161"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="192"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="910"/>
            <end position="926"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM37523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="940" mass="104320" checksum="A8411D8276DFE48C" modified="2014-04-16" version="1">MSYPPPGPGQYPHYLPPPQYQHGQIPPQGLYNSLGAPPPYDNGYGKPLMYPSTMTPYPSTYTPQPQQQQTRPPQTSPQQPLQLPPQPLQPRPQPGPQLLSQLPSPPPPQPRPPPPQLQLEELQHQFVNPSQLFVQQPLPTAPRSRYTQLSQYGEPAFVPSSSPPKISPAALPAPPPVRPIHIAPAPSPITPKPNTQTNQGQANNHIPQPRPIVKAEPTPSKISPKVKHQKKPSTPISTPKRPQPAPFPATQATPQVMARAPSPVQANIQNQTPKKQVQPHHIEKKRQPTQPNVEKHWKPTPTKSTKPPVDYQVLLLSLADEYLNAAHARGTTTSLTARETDVEEYYKLVATGLGCLEAVLKNWRLQPRKEALVRLRYARTLFEETDNDIEAETALSKGIDLCERNRMLDLKYSMQHLLARMLHKSNPKASLKAVDGMIQDVEAYRHAAWEYAFRFLRVSLSLSSPSHQDSVQALQNLHKITAMANRNGDKAVSAMAAVIESLAHLQQATNSDSIEQAQRAVAVARSHQLNDELRHIPQLTTLIQMVDICCSLLEYDVNQSGQKLKVMQALMDETLSDSNWRPDGSFSVPLNGKSAGPSSIDTGDILQVQNGTLLLSFNWLPQHDLYALCYFLSSITLSAKNSYDGRKAEKYLEEGLRMVQGNFKAPQEISESMVNANRRVQWRQSLYCNLLLQRVFLACARTDWELASQTLNDLRQVFQELGSNLLGTIECLMEYAAGTIAQATGDLNTALNIFQSPILSLDPATSKTGRNDPCRDTRILAGLNTALILRDPSHSSHPSLSALLATLEPFCQGSPNKYIQAAYFLVCATVHSESTIQTKQYLQQALQSATAISNSQITCMTLTFMSWKYFRGVVGEQAEKSARAGRAMAKRANDRMWASVTDDMLAETLERQGKGEEAQSVREEGQRLVSGLPPRLRRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W6QLX8</accession>
    <name>W6QLX8_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DNA-binding protein RAP1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PROQFM164_S04g000085</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Involved in the regulation of telomere length, clustering and has a specific role in telomere position effect (TPE).</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Chromosome</location>
            <location evidence="8">Telomere</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the RAP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QLX8"/>
    <dbReference type="STRING" id="1365484.W6QLX8"/>
    <dbReference type="OMA" id="FQGARFW"/>
    <dbReference type="OrthoDB" id="435460at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070187">
        <property type="term" value="C:shelterin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031848">
        <property type="term" value="P:protection from non-homologous end joining at telomere"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010833">
        <property type="term" value="P:telomere maintenance via telomere lengthening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd11655">
        <property type="entry name" value="rap1_myb-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11653">
        <property type="entry name" value="rap1_RCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021661">
        <property type="entry name" value="Rap1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038104">
        <property type="entry name" value="Rap1_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039595">
        <property type="entry name" value="TE2IP/Rap1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015010">
        <property type="entry name" value="TERF2IP_Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16466">
        <property type="entry name" value="TELOMERE REPEAT-BINDING FACTOR 2-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16466:SF6">
        <property type="entry name" value="TELOMERIC REPEAT-BINDING FACTOR 2-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16589">
        <property type="entry name" value="BRCT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08914">
        <property type="entry name" value="Myb_Rap1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11626">
        <property type="entry name" value="Rap1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="2 8" id="KW-0158">Chromosome</keyword>
    <keyword evidence="13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="13" id="KW-0371">Homeobox</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0779">Telomere</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BRCT" evidence="12">
        <location>
            <begin position="17"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="TERF2-interacting telomeric protein 1 Myb" evidence="10">
        <location>
            <begin position="115"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="TRF2-interacting telomeric protein/Rap1 C-terminal" evidence="11">
        <location>
            <begin position="426"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="167"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="328"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="395"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="204"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="237"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="332"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="348"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="406"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF11626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF16589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDM35204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="514" mass="57015" checksum="350A5FD0473B6F4C" modified="2014-04-16" version="1">MATFTNDSSRAETTATNLFQGARFWLSLTVPQRSRFKELIKQYGGTVVLMEKDADVKLVDHTRKDLPKDTFSYRYVERSISKGRLEDLEAHRVGPSAPRPMGASNIPTKSTRSFYTLKEDQILFDWVENFEQEPGAPIQGNKIYQDLSELFPAHPWQSWRSRYIKHLRGKGRPGGGTPLSYDELLQSAPPQGGRPKILPARISLNDSTAKSSSRVPRLAPPAPAQASTANSPKRKRDPVPEAYNRKRLDVSPTKRRAIEASDTVGLPSRRPNPDIRRPQPKSSDVAATPPFTTRPERGPPGIPLSDTGPLQGLGIPELFPVLNASIQSPSRVPRETSQRQRPADVAAPPAPPAPPRPLGDNAFAQSGRFKKQASNPRPRVKDIFKDPVDPIFLELPFLPSSPASETTDDDTSDAPDVDTWIDQRLALGAKESHVFDALRCTSMVPGMADKVLKYLTAGKGIPDDMPGVWTAEDDSCLQAEDYSRVRRVLTKHGAEAYKDRWEYFSMARQTGLIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W6QM56</accession>
    <name>W6QM56_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S02g000807</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QM56"/>
    <dbReference type="OMA" id="ANVPHCD"/>
    <dbReference type="OrthoDB" id="4252754at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM30657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="141" mass="15652" checksum="3E6CA3A0031ACBFC" modified="2014-04-16" version="1">MSGRDTRQILIVASSGQIFSPFSQLPRFPKAIMTQWIGSLTSQNGDSLAGVFMINGEPWVFEKNARGQPAVPFQRAPAVVNIPWKELESIRQSLQSREPFTATIMGSTMEIVWSNGVRITANVPHCDTYGYFSGEGGWRTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W6QM61</accession>
    <name>W6QM61_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="11">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">mak5</name>
        <name evidence="16" type="ORF">PROQFM164_S04g000145</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="11">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="11"/>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QM61"/>
    <dbReference type="STRING" id="1365484.W6QM61"/>
    <dbReference type="OMA" id="QMIQKAR"/>
    <dbReference type="OrthoDB" id="4310724at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17946">
        <property type="entry name" value="DEADc_DDX24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10 16" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="15">
        <location>
            <begin position="189"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="220"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="479"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="69"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="682"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="9">
        <location>
            <begin position="189"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="23"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="126"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="699"/>
            <end position="713"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CDM35264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="768" mass="84704" checksum="FD7E0D0F495743AB" modified="2014-04-16" version="1">MGQKRARDPKAQVSEANKRKKAVKSDKASSDDHGSLGVEDLNWKEVAMPDRMDDAEGFFGLEEIEGVDIIKQSDGGVHFKAKSGKPTKSIIKPPSEDDGDEWGGFSDEDSSKKSPTIEKAPTTTQVKEDKKSKKDKKKEQNKAMKESKEQKPKEQKSKESKPGQNQNIKAGLSFTALDDVEEDEGVDVSAWDGLNLSPETFTALSKMKFSSPSAIQKASIPLILDGHDVVGKASTGSGKTLAFGIPIIEHYLDKRGKQEEQSEQSEKNKSPIALILSPTRELAHQLGKHIGELIANSPDTNARIALITGGMSIQKQQRQLATADIVIGTPGRVWEILSTGTGLIRKMQKIQFLVVDEADRLLSEGHFKEMEDILNALDKHQAGDIADMDHEEEDEEPSQRQTLVFSATFHKDLQQKLAGKSRWASSDMLDNKASMEYLLKKLNFREEKPKFVDVNPESQMAIGLKEGIVECPAMEKDLYLYSVLLYYPKNRTIVFTNSISAVRRITQLLQALQLPVFALHSNMAQKARLRSIERFSSPTANPSSILVATDVAARGLDIKGINCVIHYHVPRTADAYVHRSGRTARAGESGKSILICAPEEVVGVARLAGKVHTKKARKAGDPDGPSKKIALESLDIDRRVVARLRPRMALAKRITDSTIAKEKVNTEDNWLRAAADDLGVEYDSDEFDPSKGRGRGRGGGRERRDKEASEVSKTEMAGLRAELKQQLSQRVNIGVSEKYLTAGRIDIDALLRGEGNDAFLGHLDPLTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W6QMF6</accession>
    <name>W6QMF6_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid/polyamine transporter I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PROQFM164_S06g000572</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792020">
        <property type="protein sequence ID" value="CDM37610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QMF6"/>
    <dbReference type="STRING" id="1365484.W6QMF6"/>
    <dbReference type="OMA" id="TYWVISF"/>
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    </dbReference>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="609" mass="65365" checksum="0C8F81640089F778" modified="2014-04-16" version="1">MSNTYQGNRNGSLAAPRDSLELASLASSSPGSVGGSSRSSSPDGVSSSRKLSLEDEDPLAESHQDAELGRRHRAQSSFSISSAFDFGRNLFPLSQTQGGYAPLGTPSADRPGFTDGSLERNKTLTYLNGLSLIVGLIIGSGIFSSPSQVNANAGSPGASLIVWAVAGLLAWTGAASYAELGGAIPLNGGSQIYLSKIFGELTGFLFAWCAVLVLKPGSAAIISLIFGEYVVRAFVGADVGDVNPWINKGVAFGGLVAVTLLNCISTKFATRIGDFFMFFKFVALLGVTVIGIIVAVTGFSAGGNANEEWKTTGWFEGTTTEISDFAVALYAGLWAFDGWDNTNYVTGEFKNPNRDLPRVIHTAMPLVIISYLLANVSYFLVLPHSTIEASNTIAVQFGAKVFGAPGALILALVVSASCFGALNATTFTSGRLVYAAGKEGYLPSIFGRIGLHASSQGPPASSRLRRRSWASRALSRFFGDNSRLGFTPIYAMAFNGVLTTIYIVVGEFGTLVTFYGVAGYTFYFLTVLGLIVLRIREPLLERPYRTWITTPIIFCCVSLFLLSRAVISEPLQTLIVVAFIITGVPVYYWRIYKRDGRIDLPSWKFWKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W6QMM8</accession>
    <name>W6QMM8_PENRF</name>
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        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S04</fullName>
        </submittedName>
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        <name evidence="2" type="ORF">PROQFM164_S04g000315</name>
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        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35434.1"/>
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        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
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            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
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            <begin position="20"/>
            <end position="33"/>
        </location>
    </feature>
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        <location>
            <begin position="42"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM35434.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="51" mass="6116" checksum="0B89E5F0E82C2604" modified="2014-04-16" version="1">MARDGEEEEAEKEEGKKAEEEQEQEQEQEQEERETERTGRQGSRKGLRHDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>W6QNH3</accession>
    <name>W6QNH3_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial</fullName>
            <ecNumber evidence="11">1.14.15.45</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">2-methoxy-6-polyprenolphenol 4-hydroxylase</fullName>
            <ecNumber evidence="11">1.14.15.46</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">COQ6</name>
        <name evidence="13" type="ORF">PROQFM164_S07g000284</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">FAD-dependent monooxygenase required for two non-consecutive steps during ubiquinone biosynthesis. Required for the C5-ring hydroxylation during ubiquinone biosynthesis by catalyzing the hydroxylation of 4-hydroxy-3-(all-trans-polyprenyl)benzoic acid to 3,4-dihydroxy-5-(all-trans-polyprenyl)benzoic acid. Also acts downstream of coq4, for the C1-hydroxylation during ubiquinone biosynthesis by catalyzing the hydroxylation of 2-methoxy-6-(all-trans-polyprenyl)phenol to 2-methoxy-6-(all-trans-polyprenyl)benzene-1,4-diol. The electrons required for the hydroxylation reaction are funneled indirectly to coq6 from NADPH via a ferredoxin/ferredoxin reductase system.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a 2-methoxy-6-(all-trans-polyprenyl)phenol + 2 reduced [2Fe-2S]-[ferredoxin] + O2 + 2 H(+) = a 2-methoxy-6-(all-trans-polyprenyl)benzene-1,4-diol + 2 oxidized [2Fe-2S]-[ferredoxin] + H2O</text>
            <dbReference type="Rhea" id="RHEA:81183"/>
            <dbReference type="Rhea" id="RHEA-COMP:9551"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10858"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:62731"/>
            <dbReference type="ChEBI" id="CHEBI:84166"/>
            <dbReference type="EC" id="1.14.15.46"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a 4-hydroxy-3-(all-trans-polyprenyl)benzoate + 2 reduced [2Fe-2S]-[ferredoxin] + O2 + 2 H(+) = a 3,4-dihydroxy-5-(all-trans-polyprenyl)benzoate + 2 oxidized [2Fe-2S]-[ferredoxin] + H2O</text>
            <dbReference type="Rhea" id="RHEA:81195"/>
            <dbReference type="Rhea" id="RHEA-COMP:9514"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10930"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:64694"/>
            <dbReference type="ChEBI" id="CHEBI:78396"/>
            <dbReference type="EC" id="1.14.15.45"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="11">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Mitochondrion inner membrane</location>
            <topology evidence="11">Peripheral membrane protein</topology>
            <orientation evidence="11">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the UbiH/COQ6 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.15.45" evidence="11"/>
    <dbReference type="EC" id="1.14.15.46" evidence="11"/>
    <dbReference type="EMBL" id="HG792021">
        <property type="protein sequence ID" value="CDM37935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QNH3"/>
    <dbReference type="STRING" id="1365484.W6QNH3"/>
    <dbReference type="OMA" id="VKQMQVW"/>
    <dbReference type="OrthoDB" id="683240at2759"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031314">
        <property type="term" value="C:extrinsic component of mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120538">
        <property type="term" value="F:2-methoxy-6-polyprenolphenol 4-hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106364">
        <property type="term" value="F:4-hydroxy-3-all-trans-polyprenylbenzoate oxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000021">
        <property type="entry name" value="Ubiquinone biosynthesis monooxygenase COQ6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000245">
        <property type="entry name" value="Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03193">
        <property type="entry name" value="COQ6_monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018168">
        <property type="entry name" value="Ubi_Hdrlase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010971">
        <property type="entry name" value="UbiH/COQ6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051205">
        <property type="entry name" value="UbiH/COQ6_monooxygenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000689">
        <property type="entry name" value="UbQ_mOase_COQ6"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01988">
        <property type="entry name" value="Ubi-OHases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43876">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS MONOOXYGENASE COQ6, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43876:SF7">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS MONOOXYGENASE COQ6, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01304">
        <property type="entry name" value="UBIH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0274">FAD</keyword>
    <keyword evidence="3 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8 11" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="domain" description="FAD-binding" evidence="12">
        <location>
            <begin position="215"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDM37935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="509" mass="54856" checksum="F3EFDBD1827A439C" modified="2014-04-16" version="1">MRPISRAVLRPYVCPTCRHGITAGRRQFASKSDSPDLYDVVCVGGGPAGLGLLAALRASPITSKLKVALIETQDLRKAKAWDLEPNQFSNRCSSLTPSTVAFLRSIGAYDKLDVSRVQEYQDMQVWDGQTGSRISFDWSMETSPFEDMRTVATMTENANLVRALLRRIADSGDENLSLFSNSTVASIENGSDLKPDGPDLSAWPIVTVKPTGPAAETEPPKRIAARLLVGADGINSPVRTFADIPTQGWDYGRHGIVATLALAEPATAPFPASKRTAYQRFLPALGGPIALLPLPNNHATLVWSTTPEHAAYLKSLPTPAFLAMVNAAFRLDMTDLTYMMGMQSSSSDSTPSHQDELAWRVQHTPLPAQVPPPATGVQTGTVASFPLRFRHAAQYVSPRVALVGDAAHVIHPLAGQGLNLGQADVASLSKTIQYAVSHGMDIGDLLALERYSSERYLPNAKIGGACDLLHKMYNVPGEGPVAWARSLGLGVVDRLPFVKSFLMKNAEGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W6QP60</accession>
    <name>W6QP60_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">trans-L-3-hydroxyproline dehydratase</fullName>
            <ecNumber evidence="3">4.2.1.77</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S10g000019</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>trans-3-hydroxy-L-proline = 1-pyrroline-2-carboxylate + H2O</text>
            <dbReference type="Rhea" id="RHEA:10320"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:39785"/>
            <dbReference type="ChEBI" id="CHEBI:57938"/>
            <dbReference type="EC" id="4.2.1.77"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the proline racemase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.77" evidence="3"/>
    <dbReference type="EMBL" id="HG792024">
        <property type="protein sequence ID" value="CDM38205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QP60"/>
    <dbReference type="STRING" id="1365484.W6QP60"/>
    <dbReference type="OMA" id="SHVLWTG"/>
    <dbReference type="OrthoDB" id="6409228at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050346">
        <property type="term" value="F:trans-L-3-hydroxyproline dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.310.10:FF:000003">
        <property type="entry name" value="Proline racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.10">
        <property type="entry name" value="Diaminopimelate Epimerase, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008794">
        <property type="entry name" value="Pro_racemase_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33442">
        <property type="entry name" value="TRANS-3-HYDROXY-L-PROLINE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33442:SF1">
        <property type="entry name" value="TRANS-3-HYDROXY-L-PROLINE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05544">
        <property type="entry name" value="Pro_racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00028">
        <property type="entry name" value="Proline_Racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54506">
        <property type="entry name" value="Diaminopimelate epimerase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM38205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="405" mass="43887" checksum="0217A79DF6F25308" modified="2014-04-16" version="1">MEIPQPLEAPGPIRPITCVEMHTAGEPTRIIWDGTPPLTGTLLEQRAQAKAQFDEFRRVLILEPRGHYDMYGAILRPETELVASGEAHIGVLFMHNEGFSTMCGHATIALGRFLVDVDEKVFPRRRELKFDPVSRTTTLNLHVPCGVVEVTVPTLDSGKSDASRPVSFVSVPSFATAISFQVPVPEKYRWAELAGRASVTADFAYGGAYYGMISAEELGFPGGLGEIKLQDMDHATKLLKEAVVTNPDLRYLIQDVRTAEEGFLYGIMITDTRLGHVSASEGTAAARAQLDASSEETGLCFFANQQIDRSPTGSCVAARVALAHAKGTLPAGEKRIYNSLVTRAYRGIPGFVGSVFDDAGTSGGDQQSVRVCVEGYAYYTGYHSFVVEKEDGLGVDGFSVRDIAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W6QPL0</accession>
    <name>W6QPL0_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S11g000038</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="HG792025">
        <property type="protein sequence ID" value="CDM38335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QPL0"/>
    <dbReference type="STRING" id="1365484.W6QPL0"/>
    <dbReference type="OMA" id="DWAFDAN"/>
    <dbReference type="OrthoDB" id="10029320at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF222">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE STCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="1">
        <location>
            <position position="377"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM38335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="454" mass="51745" checksum="1B2AD1D0FD6DC531" modified="2014-04-16" version="1">MAFSLQAYVSNQMEIGSSLPKSPMQGEFLNPISNGRDLNYMHGEEWHMWRSRFNPGFSRTNIRTWIPAIIEEVDAFANVLKGLSGGDGQWGQVFPFEQISSNLAFDVTGRVVLDTRLNSQSLYPSPFTIAYREQLSRMEITLSPRKLLWRITPLFKLIVQRKRNQLFKHLRPFITNGINAASNSPRTIIRSAVEEYTGELGGKGTANPPDEAFIEQVFYQLMIFFFGGDDALSITIPRVFRQLQLNPECVAKLRAEHDAILGSDPSVAAEKIREAPHILDSLQYTLGVIKETLRMNPATITIREGQPSFNLKINGEDEPWPTDGFDLFDSSITIHHDPANFVDPLKFMPERFSALEGDRLHPAKNIWRGFQLGPRKCIGQELAVVVLKLVLVFTVRSFDIEMAWDQWDELRELQGLKVDRRTVEGERMYTTGKATSHPKDGAPMHVRMRHWSKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W6QPR6</accession>
    <name>W6QPR6_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S12g000009</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792026">
        <property type="protein sequence ID" value="CDM38400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QPR6"/>
    <dbReference type="STRING" id="1365484.W6QPR6"/>
    <dbReference type="OrthoDB" id="276276at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="40"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM38400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="242" mass="27305" checksum="F4BEE3AE027B70DA" modified="2014-04-16" version="1">MSTARNNAGTSFKYHSIPKRIDAAIVHIPLDRLEKLYPDIQRFAAMAVVFSFHPKSPLTPRVLLIKRNGNEGSWGNTWEPGGGTPDEEDPTILHSAARESMEETQIWPLRFASNAFTCSFYHRDRKTGNQVLMRPLGFIAIDHEVTRDNGETIKNEKTMAQRIWSSGIQQPLGQSSVKISDEHLDHCWFTEDEVRSAAPYEQDTPQGPFAMLTAKRDMVLLAFQLFSQSQGHSLPPSIDIAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W6QQG1</accession>
    <name>W6QQG1_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="16 18">Delta(24(24(1)))-sterol reductase</fullName>
            <ecNumber evidence="16 18">1.3.1.71</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">C-24(28) sterol reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Sterol Delta(24(28))-reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">PROQFM164_S02g001898</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>ergosterol + NADP(+) = ergosta-5,7,22,24(28)-tetraen-3beta-ol + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16933"/>
            <dbReference type="ChEBI" id="CHEBI:18249"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.3.1.71"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="17">
            <dbReference type="Rhea" id="RHEA:18503"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="15 18">Steroid metabolism; ergosterol biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 18">Belongs to the ERG4/ERG24 family.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.71" evidence="16 18"/>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QQG1"/>
    <dbReference type="STRING" id="1365484.W6QQG1"/>
    <dbReference type="OMA" id="DMFFSMS"/>
    <dbReference type="OrthoDB" id="5326588at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000246">
        <property type="term" value="F:Delta24(24-1) sterol reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1630:FF:000003">
        <property type="entry name" value="C-24(28) sterol reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001171">
        <property type="entry name" value="ERG24_DHCR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018083">
        <property type="entry name" value="Sterol_reductase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21257">
        <property type="entry name" value="DELTA(14)-STEROL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21257:SF31">
        <property type="entry name" value="DELTA(24(24(1)))-STEROL REDUCTASE ERG4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01222">
        <property type="entry name" value="ERG4_ERG24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01017">
        <property type="entry name" value="STEROL_REDUCT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01018">
        <property type="entry name" value="STEROL_REDUCT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3 18" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11 18" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="9 18" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 18" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="14 18" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="10 18" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="13 18" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="4 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="45"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="103"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="231"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="294"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="330"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="428"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00029435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00038892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU369120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CDM31747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="473" mass="55136" checksum="7084A31EDBB2080C" modified="2014-04-16" version="1">MAMTIRQRTQPVASIPANRSKEDGSTTPTKFTDGASDEFEFGGSFGAALLMTGFPLLMWYMWIGATYYDGMLPMPKPNQTWADFGRHLCQLVYEGAYPSAKAWAIYWTFFVLEALMYCYMPGVSNFGRPLRHEGGKRLPYYCSAYCSFYATLAIAVVLHVTRVFPLYTLIDEFGPIMSVAILSGFLNSFIVYIQAIVRGRTHRLSGSPIYDFFMGAELNPRIGILDFKMFYEVRIPWFILFLITCSVAARQYETYGYVSPEVIFLVVAHYLYTNACAKAEQMIITSWDMYFEKLGFLLTFWNMAGVPFTYCHCALYLANHHPSEYHWNPYALAVFSALYIFFYWMWDSANGQKNAFRHKEKGQLIQRNTFPQVPWQAIENPKTIQTDAGDHIMVDGWFAIIRKPNYVPDMFFSMSWGLITGFKSPFPWFYFIFFMVMIIHRTNRDINRCRRKYGEAWKRYEKEVPYLFIPYVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>W6QQP2</accession>
    <name>W6QQP2_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Pre-mRNA-splicing factor prp1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">prp1</name>
        <name evidence="11" type="ORF">PROQFM164_S05g000232</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM164</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QQP2"/>
    <dbReference type="STRING" id="1365484.W6QQP2"/>
    <dbReference type="OMA" id="DGWAWYY"/>
    <dbReference type="OrthoDB" id="440128at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000244">
        <property type="term" value="P:spliceosomal tri-snRNP complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000649">
        <property type="entry name" value="mRNA splicing factor (Prp1/Zer1), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:001164">
        <property type="entry name" value="mRNA splicing factor (Prp1/Zer1), putative (AFU_orthologue AFUA_2G06070)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000256">
        <property type="entry name" value="Probable pre-mRNA splicing factor prp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010491">
        <property type="entry name" value="PRP1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045075">
        <property type="entry name" value="Syf1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246:SF1">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06424">
        <property type="entry name" value="PRP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13428">
        <property type="entry name" value="TPR_14"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14559">
        <property type="entry name" value="TPR_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="PRP1 splicing factor N-terminal" evidence="10">
        <location>
            <begin position="56"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="642"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="103"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="151"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="517"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="121"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF06424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDM36399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="973" mass="108756" checksum="FE42CF592BC8EE55" modified="2014-04-16" version="1">MDFNVGGNFFCDKIAGAGNTISPSPPSPSAPSASSSLSCVVLDMASGRKDFLSQAAPENYVAGLGRGATGFTTRSDLGPAREGPTPEQIQAALTKRAQLLGAAAPTAYGATSREKGGKDEDKEEEDERFQDPDNEVGLFAYGQFDQEDDEADRIYQEVDEKMDKRRRARREAREKAEQLEYERNNPKIQHQFADLKRTLASVSEEEWANLPEVGDLTGKNRRDKQNARQRHYAVPDSVIAGARDSAQYGTTIAEDGTETTVDEGENADSNMMNFADIGAARDKVLKVRLDQAASGTSTNIDPKGYLTSLTQSEAKAGEVEVGDIKRVRTLLESVTKTNPKHAPGWIALARLEELAGRTVAARNLIAKGCELCPKSEDAWLENIRLNEGHNAKIIAANAIKNNDRSTRLWTEAMRLETDTRAKKNVLRQAILHIPQSVQIWKEAVNLEDDPADARLLLAKAVEIIPLSVELWLALARLETPENAQKVLNAARKAVPTSYEIWIAAARLQEQMGTFARVNVMKRAIQSLVRENAMLKREEWITEAEKCESEGAVLTCGSIIQETLGWGLDEDDDRKDIWMDDAKASIARGNYETARAIYAYALRVFVNRRSIWLAAADLERNHGTKEALWQVLEKAVEACPQSEELWLLLAKEKWQSGDIDDARRVLGRAFNQNPNNEDIWLAAVKLEADAKKPDQARELLATARREAGTDRVWTKSVAFERQLGNIDDALDLVNQGLQLFPKADKLWMIKGQIYEAQNKLPQAREAYGTGTRACPKSVALWLLASRLEEKAGAVVRARSVLDRARLAVPKNAELWTESVRVERRANNISQARVLMARAIQDVPTSGLLWSESIWYLEPRAQRKARSLEAIKKVESDPILFITVARIFWGERRLEKAMTWFEKAIVLDSDYGDGWAWYYKFLMQHGTEEKRADVVSKCMSMEPKHGEIWQSIAKDPANAYKTTEELLKLVANIIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W6QSD8</accession>
    <name>W6QSD8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Aldose 1-/Glucose-6-phosphate 1-epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S02g002548</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QSD8"/>
    <dbReference type="STRING" id="1365484.W6QSD8"/>
    <dbReference type="OMA" id="IYHHISR"/>
    <dbReference type="OrthoDB" id="274691at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004034">
        <property type="term" value="F:aldose 1-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033499">
        <property type="term" value="P:galactose catabolic process via UDP-galactose, Leloir pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018052">
        <property type="entry name" value="Ald1_epimerase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008183">
        <property type="entry name" value="Aldose_1/G6P_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10091">
        <property type="entry name" value="ALDOSE-1-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10091:SF0">
        <property type="entry name" value="GALACTOSE MUTAROTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01263">
        <property type="entry name" value="Aldose_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00545">
        <property type="entry name" value="ALDOSE_1_EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM32397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="337" mass="37004" checksum="846BB525C020A0F1" modified="2014-04-16" version="1">MSEQAAFHFLPLGAIIQTFSVGGKNIVLNFPTQEDYVKHNTPHYGATIGRVANRIKDGLIQELNGQKVQLVQNNGPNSLHGGENNWAKRVFDGPFTVQRNGHDAVHFKYLCRDGSEGFPGTIEVRVWYIASNEDAKTVLTAEYEVEFVGNEYEVEFVGNECEETVVNITNHSYFNIGDGPDISGTTAQLATADYLPLDSTGIPSGEIAKFPRDVTAPFALAATGAHFDDVFVLESDPSKIPLDTRGLPLRRLAQFSNASSGLHLEVYSTEPAFQFYTGKYLDVPSVNGAPAHHEGAAFCVEPSRFVNAINEPAWRSMVLLKKGQLFGCKTVYKAWKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W6QSQ6</accession>
    <name>W6QSQ6_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosome production factor 2 homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Ribosome biogenesis protein RPF2 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">RPF2</name>
        <name evidence="7" type="ORF">PROQFM164_S02g002673</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Nucleus</location>
            <location evidence="1 4">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the RPF2 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QSQ6"/>
    <dbReference type="STRING" id="1365484.W6QSQ6"/>
    <dbReference type="OMA" id="VGLKPMF"/>
    <dbReference type="OrthoDB" id="407658at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007109">
        <property type="entry name" value="Brix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039770">
        <property type="entry name" value="Rpf2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12728">
        <property type="entry name" value="BRIX DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12728:SF0">
        <property type="entry name" value="RIBOSOME PRODUCTION FACTOR 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04427">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00879">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50833">
        <property type="entry name" value="BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Brix" evidence="6">
        <location>
            <begin position="28"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="236"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="278"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="246"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM32522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="338" mass="38469" checksum="F79012501ED4480A" modified="2014-04-16" version="1">MLREVKAKNPRTARILKSREPQLIEPPKKTLIFHGAKCPQTLDTVLKTFHALTKPYNVLFHKKNENLHPYENSESLEFLANKNECGLVAFGSHNKKRPNCVTLARIYNSELLDLVELLLLPPRDGEVIPPINELVMDVGLGLRPMMLFSGSPWDDPTSTAHKILKSTLLDMFRGEETTQVDVEGLQYVMMVGAEEPQDGLSPVIHIRWYRVITKRSGHKLPRVELQEVGPKFDFKVGRTRQAAPEVQKESMKQGKRPNDEARTKKNIIMDSMGDKIGRVHLGKQDLSDLQTRKMKGLKRRAGMESSDEEEEPSADMMEVDVVSSDEEEEETHKKARKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W6QU04</accession>
    <name>W6QU04_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Fructose-2,6-bisphosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PROQFM164_S06g000586</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792020">
        <property type="protein sequence ID" value="CDM37624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QU04"/>
    <dbReference type="STRING" id="1365484.W6QU04"/>
    <dbReference type="OMA" id="VKTHVFH"/>
    <dbReference type="OrthoDB" id="267323at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003873">
        <property type="term" value="F:6-phosphofructo-2-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004331">
        <property type="term" value="F:fructose-2,6-bisphosphate 2-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006003">
        <property type="term" value="P:fructose 2,6-bisphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006000">
        <property type="term" value="P:fructose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1240:FF:000031">
        <property type="entry name" value="6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003094">
        <property type="entry name" value="6Pfruct_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013079">
        <property type="entry name" value="6Phosfructo_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10606">
        <property type="entry name" value="6-PHOSPHOFRUCTO-2-KINASE/FRUCTOSE-2,6-BISPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10606:SF39">
        <property type="entry name" value="6-PHOSPHOFRUCTO-2-KINASE_FRUCTOSE-2,6-BISPHOSPHATASE YLR345W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01591">
        <property type="entry name" value="6PF2K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000709">
        <property type="entry name" value="6PFK_2-Ptase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00991">
        <property type="entry name" value="6PFRUCTKNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphofructo-2-kinase" evidence="4">
        <location>
            <begin position="45"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="466"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="490"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="506"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDM37624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="522" mass="60130" checksum="8043CBACB734AD5D" modified="2014-04-16" version="1">MDTLLTAEIVANSPRFRRKSSIFVDAIHDLPEKADLAPAQLYSTESGRLFHSGRIVIITVGLPARGKTHISVALARYLRWLGVKTRIFHLGDYRRATIPFGEDMPDDYFYVNATAKSVLLRQKIVRKCREDIYHFLNHENGQIAIYDAVNPLTLFIESWCDDERIIEENVRRVKISSPDYVSWKSEDAVKHYLNRIYSRIPQFQTMEEKDLNFIKMINAGERLIVNNRSFGYLSNRIVFYLLNLHIKSRRTYFARAGVSLDAGSYKADTSLSDQGEDYAKKMTARLLAHREEEKQAMIERGETGYESRPLKVWTSTRRRTVETAKYFHENGYKVRQRSQLSQLNPGVCEKMSEDRIRAEFGDEVAKHELDPYHHRYPRAESYHDLAVRLEPIILELEREQTDLLIIAHESVLRVLYGYLMACNAADIPFLEFPRDEIIEILPESYQNEAQRIHIPDLPEEIIPASPEDLKIPVPPSGVVSPAQGLGSPDGQVTPQSGHRTPSGIRTPRERERISQQHVEDVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W6QU55</accession>
    <name>W6QU55_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Zinc-regulated transporter 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">ZRT1</name>
        <name evidence="9" type="ORF">PROQFM164_S02g003213</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ZIP transporter (TC 2.A.5) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM33062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QU55"/>
    <dbReference type="STRING" id="1365484.W6QU55"/>
    <dbReference type="OMA" id="YNPGSFT"/>
    <dbReference type="OrthoDB" id="448280at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000006">
        <property type="term" value="F:high-affinity zinc transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071578">
        <property type="term" value="P:zinc ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004698">
        <property type="entry name" value="Zn/Fe_permease_fun/pln"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00820">
        <property type="entry name" value="zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040:SF32">
        <property type="entry name" value="ZINC-REGULATED TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040">
        <property type="entry name" value="ZINC/IRON TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="109"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="195"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="255"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="298"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="330"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM33062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="351" mass="38492" checksum="E1F11CF1652FC767" modified="2014-04-16" version="1">MSFDPHNVDLDTADPTDIVCYLNSEGNEYNGQLGARISAIFVIMFISSAATFFPVVAQRVPRLRIPVYVYLFARYFGAGVIVATAFIHLLDPAYDEIGPASCVGMTGHWADYSWCPAIVLTSMMMVFLMDFGAERYVEIKYGICREDPEPIMSTGGEVRRVDSRVSGRHADDKQAKEIESQSEEVAIERSVRQQIAALLILEFGVIFHSVIIGLNLGVAGDEFATLYPVLVFHQSFEGLGIGARMSSIPFKKGSWLPWFLCTAYGLTTPISIAIGLGVRTTYNPGSYTANVVSGVLDAISAGILVYTGLVELLARDFLFDPHRTQDNKRLAFMVISMLLGAGIMALLGKWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W6QUC7</accession>
    <name>W6QUC7_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase-like domain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S07g000082</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792021">
        <property type="protein sequence ID" value="CDM37734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QUC7"/>
    <dbReference type="OMA" id="LTENCQM"/>
    <dbReference type="OrthoDB" id="5404599at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM37734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="138" mass="15965" checksum="A81D0D1F1B1E074F" modified="2014-04-16" version="1">MFGGVDGKYMPENYLTNLYNRDFRPQELTENCQMLGMDCSTFVFYHADLGPVNIIVEDIPKAGTIGIIDWEIAGYVPKGWIRTKFRLSSGLDLPDASPGEESYWWRSEVQKLLEKRGFVDHAKEWTAWRRNKPISQTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W6QVX2</accession>
    <name>W6QVX2_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Amino acid/polyamine transporter I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PROQFM164_S03g000446</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QVX2"/>
    <dbReference type="STRING" id="1365484.W6QVX2"/>
    <dbReference type="OMA" id="GIMLQML"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF15">
        <property type="entry name" value="CHOLINE TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="43"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="122"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="197"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="275"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="328"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="382"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="406"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="448"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="476"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM33722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="546" mass="59289" checksum="88B396FBD5E6E49F" modified="2014-04-16" version="1">MAVFSWQSSRDTEKPPKGHAAMDEVRLESALGHKQELPRNFGMWSLTSLGIVIANSWASTGGTIVAALQNGGPMAVLYGLILVSIFYTTISASLAELASSMPSAGGVYYWSSVLSRNRGRTAGFFTGYLNACAWLLSASSMSSMLGNEGVAMYLLKYPNVKWKSWQVFIVFQIVNWACCAIVCLGNRFIPVINRLSLILSMCGLVTTIVVLTVMPKDHASNTQVWTEYHNNTGGWSDGVCFMTGLLNAAFAVGVPDCISHLSEEVPKPEIKVPQGIMLQMLTAFVTSFVYLIALFYSIQDLDAVFASNIGFFPTAEIYRQATGSNAGAIGLIAVLFLATFPTLIGTFVTGGRMWWSLARDNATPFSNYFAQVHPTLNCPVRATVAMSALVTCLGCIYIGSTTAFQALISSFIVLSSLSYFGAIFPHVLSGRGNMVPGPFYMGQKLGMAVNIVSLMYILVTVIFFCFPLVLPATVENMNYTSVIVVGLMALTASWWVFRGRRQYNGPQYSFEAAERLAAFQEGKQGRRSFIDLVGVSPVGIEHGNAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W6QW83</accession>
    <name>W6QW83_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S03</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S03g000466</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QW83"/>
    <dbReference type="OrthoDB" id="4375162at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004880167" evidence="1">
        <location>
            <begin position="17"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM33742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="72" mass="8021" checksum="730A0A3F99897C0C" modified="2014-04-16" version="1">MIILIFGLRDLVSVLAHASLHCVIGLTLPPIDANSFSSTVRLVRALGEDGMFRIYNNNHCYCSGDDTFYLLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W6QWS5</accession>
    <name>W6QWS5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S39g000001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792053">
        <property type="protein sequence ID" value="CDM38610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QWS5"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM38610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="75" mass="8390" checksum="E40FF8EE2F15BFF7" modified="2014-04-16" version="1">MLRGLIRHVLFLSRRFCHRPPSSETWTVLTIVEAVVIIDCTRGLRAVCLSDPGINIHSTILILEGTEAGDWSQFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W6R4M6</accession>
    <name>W6R4M6_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S05g000585</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6R4M6"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM36752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="57" mass="6356" checksum="B8B58B21805207C6" modified="2014-04-16" version="1">MDPIFSFSQVDICHTQLSLNSHLERMEADASTETGMILVTQGLVETMCCHRARGSRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W6R5I9</accession>
    <name>W6R5I9_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PROQFM164_S06g000042</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792020">
        <property type="protein sequence ID" value="CDM37082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6R5I9"/>
    <dbReference type="OMA" id="NTPSHES"/>
    <dbReference type="OrthoDB" id="4682787at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF93">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="38"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="75"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="5"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM37082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="214" mass="24058" checksum="1A4001D6A9D41386" modified="2014-04-16" version="1">MISLSIVSMMTALIFWFQRVPSRSIWDHRVPGYTVVPVTPFSVMLGCWCAAVDFYFTLLPWIFIWNLNMKFKEKMSIAISLSLGFMCVSHPILHGYIVILVSRACICGIIRTIDLGGLASSNYTEDTVNLIIWSAVELAVTLICVGIPTVRPLYRTIVHGSHSESSEGKYVKPRYSRSDEEILVGQYGSSNDGIRVHEEVRVERTSSYVAHSCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2024-10-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>W6R8L3</accession>
    <name>W6R8L3_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S10g000016</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792024">
        <property type="protein sequence ID" value="CDM38202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6R8L3"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM38202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="138" mass="15460" checksum="253864D2BFD09EC0" modified="2014-04-16" version="1">MFSREIKRYIKRYITFGSRGMRHAVDVQNTHLLLMEEGEIVSSMVEMEQEQSTRVGGLLETPVSKPLCPSSCVRRARGVGPRMAPSCVTLGHTSLCGVQTICLSPAWDRCVAKMPNTPDMFKYGSPTEHEQVRERGSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2024-10-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>W6PQ22</accession>
    <name>W6PQ22_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S01g000082</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PQ22"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM26273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="57" mass="7029" checksum="DAFDC58F8AD6B987" modified="2014-04-16" version="1">MDHDDQRDNRLQFPRRVNAARVVGFPARLVTYVVLHMKIKHLIFYNRLDRDSYRTWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W6PQF9</accession>
    <name>W6PQF9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S01g000227</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PQF9"/>
    <dbReference type="OrthoDB" id="4283334at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM26418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="55" mass="6317" checksum="DA80D1EC9E2B7D91" modified="2014-04-16" version="1">MLRFFATHGELHSPSSQHWVLPRAARPLANEKFGGIFKPRPAPSFVFARRRRSCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W6PRQ5</accession>
    <name>W6PRQ5_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 10">Signal recognition particle subunit SRP68</fullName>
            <shortName evidence="10">SRP68</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PROQFM164_S01g000359</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). The SRP complex interacts with the signal sequence in nascent secretory and membrane proteins and directs them to the membrane of the ER.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the SRP68 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PRQ5"/>
    <dbReference type="STRING" id="1365484.W6PRQ5"/>
    <dbReference type="OMA" id="DERFIHI"/>
    <dbReference type="OrthoDB" id="10255118at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030942">
        <property type="term" value="F:endoplasmic reticulum signal peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005047">
        <property type="term" value="F:signal recognition particle binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15481">
        <property type="entry name" value="SRP68-RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3450.40:FF:000002">
        <property type="entry name" value="Signal recognition particle subunit SRP68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3450.40">
        <property type="entry name" value="Signal recognition particle, SRP68 subunit, RNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026258">
        <property type="entry name" value="SRP68"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034652">
        <property type="entry name" value="SRP68-RBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038253">
        <property type="entry name" value="SRP68_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12860">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 68 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12860:SF0">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE SUBUNIT SRP68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16969">
        <property type="entry name" value="SRP68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038995">
        <property type="entry name" value="SRP68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 10" id="KW-0733">Signal recognition particle</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="372"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="588"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="373"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR038995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDM26550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="611" mass="67165" checksum="D28498C2DB80106F" modified="2014-04-16" version="1">MEVTDFIFKEREEALLVGDYNAYRAHTTRKLQKLRKKLGQATVKGRKYTAKPAVTAENLGSNVSYVHLLLLSSERAWAQAMHMKSTHSADTSAKGISGAARRHIISRLNKATGYAQHLVSLLHEQSLSGASDMDILESRAYLAMISGTLWLEKRRWEQCLQDYSIARVIYTALGQRVKKDAFRDLVSGTVDPSLRYAAYQMKLPRSKPTSSLAIEFFPSDSEICAEVEKIDPSCLAEEAAGTRRTAEGEVQELPQSVTWRSRTVPLDDASISQSLAAASAAEARLTTWLADAGKSAAAKEKAAAYDNVIIASQDAVDATKSAIDDLASEGVDPSDKRMQALQITRTAVNYTLVGWRVGRNRVLCGERDGLSFEEQQPTTSGKETAKHTTGNGKKLNRLRERVVLYDSTLQSLEFILELPGVAADSAFVQGLEAKRHYFRALRCLALGRSHGVLSRSKEALALFSQALNLAASVSPQSATDAEDVPKLDVSQVQASTLESTLRELVAQYRGLVTLEKVTAEEASQSSQRPVVERLQQFAGSGLDLNNLVPYPPQMQPIPVKPLFLDVAWNYIDYPREGGQRQEALTQTQAQAQGPVEEETKGRRGWFGFGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W6PRZ4</accession>
    <name>W6PRZ4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="5">60S ribosomal protein L44</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">RPL44</name>
        <name evidence="5" type="ORF">PROQFM164_S01g000797</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL42 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PRZ4"/>
    <dbReference type="STRING" id="1365484.W6PRZ4"/>
    <dbReference type="OMA" id="CKKHTIH"/>
    <dbReference type="OrthoDB" id="2967263at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.80:FF:000001">
        <property type="entry name" value="60S ribosomal protein L44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000552">
        <property type="entry name" value="Ribosomal_eL44"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053708">
        <property type="entry name" value="Ribosomal_LSU_eL42"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10369">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L36A/L44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00935">
        <property type="entry name" value="Ribosomal_L44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01172">
        <property type="entry name" value="RIBOSOMAL_L44E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDM26988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="106" mass="12122" checksum="627591F33C1DC8B8" modified="2014-04-16" version="1">MVNIPKTRRTYCKSKECHKHQQHKVTQYKAGKASLFAQGKRRYDRKQSGYGGQTKPVFHKKAKTTKKVVLRLECTACKAKKQLALKRCKHFELGGDKKTKGAALVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W6PS26</accession>
    <name>W6PS26_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TatD superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g000365</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PS26"/>
    <dbReference type="OMA" id="VPCFGWH"/>
    <dbReference type="OrthoDB" id="413993at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053044">
        <property type="entry name" value="Metallo-hydrolase/TatD-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001130">
        <property type="entry name" value="TatD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47345">
        <property type="entry name" value="CUT9-INTERACTING PROTEIN SCN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47345:SF1">
        <property type="entry name" value="CUT9-INTERACTING PROTEIN SCN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01026">
        <property type="entry name" value="TatD_DNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="242"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM26556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="395" mass="44217" checksum="B927C3586BF4BB1A" modified="2014-04-16" version="1">MPEDEPFPWDIGVYDAHCHPTDTLASVADIPQMKATTLTIMATRGEDQDLVQQTAVSLSAKTSQSMADRVVPCFGWHPWFSHQILDDTTQPTAAQNPAEHKSTHYAAVLAPSPADDQPFVDLLPVPKPLSELISETRNRLQQFPNALVGEVGLDRSFRLPSPWTPTDIDNRDDQLTPGSREGRRLSNYRVKPEHQRTVLKAQLQLAGEMNRAVSLHSVQAHGGVFEVLKELWAGHERVMLSRRKRDKQRDAEGAVSDDDDDDNDGDKTLEGCVSTKASIPKGKSYRPFPPRICMHSYTGSVEPIRQFLHQSNPSDVYFSFSKLINFSGAAEKKVGDVIKALPEDRILIESDLHVAGAQMDELLEDVARQVCQLRGWELRHGVQVLADNWRRFVFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W6PS80</accession>
    <name>W6PS80_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tachykinin family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g000534</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PS80"/>
    <dbReference type="OMA" id="WRSIWDE"/>
    <dbReference type="OrthoDB" id="3469225at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540">
        <property type="entry name" value="TRANSCRIPTION FACTOR (ACR-2), PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540:SF5">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM26725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="581" mass="64820" checksum="8037BCB93F4386B7" modified="2014-04-16" version="1">MDHLQPFTFGSTHSEPKAKPAPLDRPSFTFIDHDDDLTSKRIKDVNARKAIRSHVMRDVRRRERLAGLKRTSRQNRGQSNASKATINESDEQRLVLRASSQSSASSSILDTDSGDGFTSIYRGRPVRWCAGYPLPLHSNPNPPTSWFLDPFFTLPGTSELPSMVAHLVYYWKTIFVPMTFPNTSKDSKQEMELMVRSSFSDPGSFFGLMSMCAAHRAVLASQRSGNWDSVLTNDPDYCMMRAKSIQEMSAKVRDPNRRLSNEAFDTIVNLLTGSLIIGEFSEVHTHLTGLKSMVDLRGGITDESIRSSSMLSAIITTDIKAASGLMTKPVFPLTWDAQPIPSEIQQRIRPLASSPLNRLGTGFSVNTFLSPPLLKIISVLRDMVFFSITYQTNPTVIKPGDQDFFRILNCETEHQLLSYIYAEGSPNPEPNLHPIEAVTRVAAICYLNHFLIVSPSSSGLGRALTKHLKTALDSCKLSLLVGLPKQNFGLYVWALFIGAQGALGQPERQWFVERLARVAMICGWQSWEQISKLMAEFFFVTALDSLNWRSIWDEAMTGFVISESEELEFSSLLGTGALSLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W6PTV3</accession>
    <name>W6PTV3_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RTA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PROQFM164_S01g001084</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PTV3"/>
    <dbReference type="STRING" id="1365484.W6PTV3"/>
    <dbReference type="OMA" id="WECLGLI"/>
    <dbReference type="OrthoDB" id="5384040at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF15">
        <property type="entry name" value="LIPID TRANSPORTER ATNI-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="156"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="201"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="241"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="283"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="283"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="293"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM27275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="334" mass="38023" checksum="067DC5DA4347913E" modified="2014-04-16" version="1">MGWPTHCDLSSEDAQYAYCANGPAAVFFTVIFGLTWIAHFAQAVMYRKKFCWVIVVGTVWQCIGMIMRTYSTIDQTKSTTTAAGQLLILLTPLWVNAFVYMIFGRMVYYFLPEKKVAGIRAERLAQIFIWLDVSSFIVQATGGIMDSDFSTEMNKIGLHIYTAGIAAQQFFILCFCGLLFAFHRRMQERGSISRGGGWRPLVMAMWATLTFITIRIIYRLIEFADTDKAGTSPLTLHEAPFYCLELLPMLSAMVIWNIWHPGRYLQGDDCDFPKKVKLSRNEKKMIKQEAKDSKRRGHRRSSSRKGARVSESHPANSFDEGALESQGYPLRGHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W6PUD1</accession>
    <name>W6PUD1_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">CAAX prenyl protease</fullName>
            <ecNumber evidence="15">3.4.24.84</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">STE24</name>
        <name evidence="19" type="ORF">PROQFM164_S01g001619</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Proteolytically removes the C-terminal three residues of farnesylated proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 15">
            <text>Hydrolyzes the peptide bond -P2-(S-farnesyl or geranylgeranyl)C-P1'-P2'-P3'-COOH where P1' and P2' are amino acids with aliphatic side chains and P3' is any C-terminal residue.</text>
            <dbReference type="EC" id="3.4.24.84"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14 15">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="14 15">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Endoplasmic reticulum membrane</location>
            <topology evidence="1 15">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12 15">Belongs to the peptidase M48A family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.84" evidence="15"/>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PUD1"/>
    <dbReference type="STRING" id="1365484.W6PUD1"/>
    <dbReference type="OMA" id="FVIEEKF"/>
    <dbReference type="OrthoDB" id="360839at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07343">
        <property type="entry name" value="M48A_Zmpste24p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2010.10:FF:000002">
        <property type="entry name" value="CAAX prenyl protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2010.10">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027057">
        <property type="entry name" value="CAXX_Prtase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032456">
        <property type="entry name" value="Peptidase_M48_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10120">
        <property type="entry name" value="CAAX PRENYL PROTEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16491">
        <property type="entry name" value="Peptidase_M48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 15" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 14 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 15" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 15 19" id="KW-0645">Protease</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7 14 15" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="195"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="310"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="CAAX prenyl protease 1 N-terminal" evidence="18">
        <location>
            <begin position="40"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M48" evidence="17">
        <location>
            <begin position="228"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="436"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="439"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="active site" evidence="13">
        <location>
            <position position="298"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="13">
        <location>
            <position position="380"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="376"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00060927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR627057-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR627057-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU366005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF16491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CDM27808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="456" mass="51855" checksum="5642FD9FD8D4B2B6" modified="2014-04-16" version="1">MYILEQLARLLDRPLFPWKNVLVGFSVGQFVLEGFLSLRQYKFLQRTKPPQVLEGEVTQKVFDQSQAYGRAKAKFGFISGLYGQVQNLAFIYGDVLPKIWGLSGLVLARYLPGRFQGEICQTLVFFFGFNIISTILSLPISYYNTFVLEEKFGFNKQTVKLWITDMLKGQMLGIVLGTPIITAVLKIVQKFDTSFYYYLWLFGVFLQIFAITIYPIAILPLFNKLSPLQPGELKTGVENLAKRLNFPLSELHVIDGSKRSAHSNAYFYGLPWKKHIVIYDTLIEKTEPEEVVAVLGHELGHWSLSHTTKLFGIAQAHMFYIFALFSVFVNNKSLYQSFGFINEQPIMIGFLLFSDALAPMDAVVKLLMNILSRKFEFEADKFAQNLGYSDKLASSLLKLQIQNLSTMDADPIYASYHYSHPILTERLAALGWKGGKVTSNKEEDSEKPVKAADREL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>W6PVA3</accession>
    <name>W6PVA3_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DNA replication licensing factor MCM7</fullName>
            <ecNumber evidence="12">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">mcm7</name>
        <name evidence="12" type="synonym">MCM7</name>
        <name evidence="14" type="ORF">PROQFM164_S01g001522</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the MCM family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="12"/>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PVA3"/>
    <dbReference type="STRING" id="1365484.W6PVA3"/>
    <dbReference type="OMA" id="AQHVTYV"/>
    <dbReference type="OrthoDB" id="3207464at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097373">
        <property type="term" value="C:MCM core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006279">
        <property type="term" value="P:premeiotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17758">
        <property type="entry name" value="MCM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.10:FF:000004">
        <property type="entry name" value="DNA replication licensing factor MCM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000288">
        <property type="entry name" value="DNA replication licensing factor MCM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008050">
        <property type="entry name" value="MCM7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF26">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24901">
        <property type="entry name" value="WHD_MCM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01663">
        <property type="entry name" value="MCMPROTEIN7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 12" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="13">
        <location>
            <begin position="401"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU365012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDM27711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="811" mass="90677" checksum="3EEBE3E978E28223" modified="2014-04-16" version="1">MSLLQYPPPVDYSAQLNSFKDFLKGFKTFQSSSEAAATEALEDLNIDDGTSDEYDFMDDADETNGANTRGARRHREPKLKYMQILQDIANRDKSNILIELDDLSIFEKSLPEGEDLKLVQSIEKNTKRYIDVISQAIDAVMPRETKDVTFKDDVLDVIMSQREKRNETMETAMEADMEAAATAPSMFPPELTRRYTVNFKPLTPSGSSAERDSKALAVRYVRGEHIGTLITVRGITTRVSDVKPAVQINAYTCDRCGCEVFQPITTKQFLPLTECLSEECKKNNSKGQLFLSTRASKFVPFQEVKIQEMADQVPVGHIPRALTVHCYGALTRQLNPGDVIDVAGIFLPTPYTGFRAIRAGLLTDTYLDAQHITQHKKSYNEVGMDSRTLRKIEQHQRSGNMYEYLSRSIAPEIYGHLDVKKALLLLLIGGVTKEMGDGMHIRGDINICLMGDPGVAKSQLLRYITKVAPRGVYTTGRGSSGVGLTAAVMRDPVTDEMVLEGGALVLADNGICCIDEFDKMEDSDRTAIHEVMEQQTISISKAGITTTLNARTSILAAANPLYGRYNPRVSPVENINLPAALLSRFDVMFLLLDTPSREGDEELAQHVTYVHMHNKHPESEEAGVLFTPHEVRQYVAKARSYRPIVPTNVSDYMVGAYVAMRKRQKIDESKKRQFSHVSPRTLLGIVRLSQALARLRFSEEVVREDVDEALRLIEISKASLYSEGEQGSDNTPSSKIYNLIRSMKESGAAAIGDGEEGEMSMRRIRERVLARGFTEDNLTMTIDEYAEMNLWQVTGNGTRLLFTEVDDDMDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W6PWD9</accession>
    <name>W6PWD9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g002384</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PWD9"/>
    <dbReference type="OMA" id="IHIHVCD"/>
    <dbReference type="OrthoDB" id="4932058at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.30">
        <property type="entry name" value="HIT family - CDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004879453" evidence="1">
        <location>
            <begin position="23"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM28573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="326" mass="34567" checksum="5E2A48F0526F9920" modified="2014-04-16" version="1">MKIYEHCIALTLSLFLATPVFGQRFINATNGINPTNGTQNGRLCTSDDIARRDVRGCTCPSTFPASPNDLVCVTPSGQCPITCNPPPPPSPVIPRAQLSQCDAGCVDANSECNGCFIWFSSLCHCLQDFQSGNQTTCIASPPIPVGPPRTNQSASWVVLSSGDLITTTDLIPGILQLSSAADVDGGFRLGQDTLNSRGIRDTGTLAINSVATRSEEQIHIHVCDHPGSAVRRILDNLPRENYNTTSSVDLSALSQPSAAMSCRVSSNAGQDINLGGDIVDWLNQYAGNTTCAQYNVGAGVVTDSNDYSWSCITTGDRAAEDLFCSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>W6PWN1</accession>
    <name>W6PWN1_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">mcm4</name>
        <name evidence="14" type="ORF">PROQFM164_S01g000168</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the MCM family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3"/>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PWN1"/>
    <dbReference type="STRING" id="1365484.W6PWN1"/>
    <dbReference type="OMA" id="AFFKCNV"/>
    <dbReference type="OrthoDB" id="10251574at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097373">
        <property type="term" value="C:MCM core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902975">
        <property type="term" value="P:mitotic DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006279">
        <property type="term" value="P:premeiotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17755">
        <property type="entry name" value="MCM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.10:FF:000003">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000217">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008047">
        <property type="entry name" value="MCM_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF66">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21128">
        <property type="entry name" value="WHD_MCM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01660">
        <property type="entry name" value="MCMPROTEIN4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="9 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="13">
        <location>
            <begin position="579"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="326"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="51"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="99"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="115"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="326"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDM26359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="1001" mass="109940" checksum="1845B6833BE6BA49" modified="2014-04-16" version="1">MSSPTQRRSGRSSKNSTSSPSSSSRQEPPSSPTFQATPRASRRPLAGGAAPSSSPIFFQSSPTKGNNNAETPDERMADASSTVDDGDRTPRGNPGVRDSSPIHYIPSSSPTRGFGRSDIRSDIRSDALSSASSGLFVSPGGQGRRGGPRRSDLHSGGFGSTSGRRNRVFVDANGMPTGDTMPRSDATFSNINPGTSEAEAIAGNSTRVIWGTNISIIDSMSAFKNFLYNFATKYRLWADGATEDETRLLGELAERHECITMCNNMRRLGVNTFNLDAANLKSYPLTRKLWHQLSAYPQEIIPLMDQALKDVMVDLALKEMDVLRSESQRAAQPRDRRGQPILTSDNAIPTVDVPDLVGEVEAMTFKVLPFGLDQTVNMRDLDPADMDKLISIKGLVIRATPIIPDMREAFFRCSACSYGVQVDIDRGRIAEPTVCPRDGCKEKNSMQLLHNRCTFGDKQVIKLQETPDNIPDGQTPHSVSLCVYDELVDVCKAGDRVEVTGIFRCSPMRVSARQRSQKSLFKTYIDVLHVQKFDRKKMGIDMSTVGQEMSEQAAEADQARKISAEEEEKIKRTASRPDIYDLLSRSLAPSIYEMDDVKKGILLQMFGGTNKTFHKGGNPRYRGDINVLLCGDPSTSKSQLLRYVHKIAPRGVYTSGKGSSAVGLTAYVTRDPDTRQMVLESGALVLSDGGVCCIDEFDKMNDSTRSVLHEVMEQQTISIAKAGIITTLNARTSILASANPIGSRYNSKLSVPQNIDLPPTLLSRFDLVYLVLDRVDETEDRRLAKHLVGMYLEDNPENASSQEILPIEFLTAYITYAKTNCHPVITPAAGAALTEAYVAMRQLGDDIRAQERRITATTRQLESMIRLSEAHARMRLSPEVTVGDVEESVRLIRSAIKQAATDSRTGLIDMGLLTEGSSASDRRLRDDLKKAVLSRLDERGGVSGGAVRWTDLYRDVSEQSDLRLDHNQFGDALRSLEAEGSVNIFGEGARRSIRRAAMSMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W6PWV0</accession>
    <name>W6PWV0_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S01g002231</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PWV0"/>
    <dbReference type="STRING" id="1365484.W6PWV0"/>
    <dbReference type="OMA" id="RIETHSH"/>
    <dbReference type="OrthoDB" id="4337659at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM28420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="216" mass="24602" checksum="A542221B088CA0F1" modified="2014-04-16" version="1">MCWLDTRKTKADFVQVQKLELQAFSDLGLQRTLNRISHPIFRSLLGCFSVTQILATKLVITASEIITIVKPILEGIQHLAECGRVLATLTMNTIFFTQSGKVKIVGIEDSCEISAWEMDAATMKLYALADIVIKLMGKCHSTHKWPVEIENLPDQLRKRPLREILQVIGPLLFNVSRLMSQTTPFQQRPSPEELKSLINLTNKIVYHRIETHSHRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W6PY24</accession>
    <name>W6PY24_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g002970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PY24"/>
    <dbReference type="STRING" id="1365484.W6PY24"/>
    <dbReference type="OMA" id="TTDMVRC"/>
    <dbReference type="OrthoDB" id="2567806at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031349">
        <property type="entry name" value="Tfb6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37781:SF1">
        <property type="entry name" value="ADR380WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37781">
        <property type="entry name" value="TFIIH COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17110">
        <property type="entry name" value="TFB6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="39"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM29158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="285" mass="31042" checksum="B87F8755D5118EF8" modified="2014-04-16" version="1">MSPASVKNEQDSDSDSDVEFEDVPISLPNRPRNREDRGIPITIPATPQPQWTPTLSLPPQRSQPIPSGSEEEVQLRGHISTGIERVTYRKMKSDMGMDAPGTPASERRYNGFKELAADVEGLIDALWASATPAIQTEALITLAGLTQTSLPAFPFDAPPTLNILYKLDSVFAALCTGTHPLTGAVLPGAQLGHSLVTETQKVRIRSLAERTRYEVFSCLEKSKDGVNAGTVNTGGYGYGDDEDEDSGDEVEPWMLEATRVYEKSLMLLAEQDPEVDAGMDEFNCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W6PYF3</accession>
    <name>W6PYF3_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Major facilitator superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PROQFM164_S01g002871</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the major facilitator superfamily. DHA1 family. Polyamines/proton antiporter (TC 2.A.1.2.16) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PYF3"/>
    <dbReference type="STRING" id="1365484.W6PYF3"/>
    <dbReference type="OMA" id="MYMCFAA"/>
    <dbReference type="OrthoDB" id="446368at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF186">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="80"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="148"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="205"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="234"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="313"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="345"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="420"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="453"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="488"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="82"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDM29060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="554" mass="60625" checksum="B821D7C3DBE20EFE" modified="2014-04-16" version="1">MAVVPEATVSNNEIPQQVKNSQASSRRMSWIQYLFFHARLNDNVCNQNYTGKGTEDDPYIIDYLHNDHQDAMNFSNGRKWAISILQSLSTFVVTFSSSVYVSGIGGIEQQFNVSEEVATLGLSFFVLGFAVGPLIWAPLSEMYGRKSIYVISFMAYTAFSVAAACSPNIAALLVLRFFASAFGSSSMTNTGGVIADMFSKTQRGVATGFFVTAPFLGPALGPLAGGFLAEKQGWRWPLGLIAIMAGVVSIITMLITPETYAPLILQRRAEALSRVTGRVYVSRINAGKPPKTFSQELLISLTRPWILLFREPIVLLTSLYVAIIYGTLYMFFAGFPIVFQYTRGWSQGIAGLPFIGVAIGVCLATLAAGVDNKRYVRLCKEIDAGGGTVEPEARLSTAMVGSFVVPIGLFMFAWTTYPSVHWIVPIIGAVFFSCGLVMVFISLMSYLIDSYTVYAASVMAANSVVRSLFGTAFPLFTTQMYEKLGNQWASSIPAFLVLACVPFPFLFYKYGPQIRSKCKYSLEAAKVLETMSRRQGAMIVGEPNGLESKVEETV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W6PYS9</accession>
    <name>W6PYS9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADH:ubiquinone oxidoreductase, ASHI subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g002987</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PYS9"/>
    <dbReference type="STRING" id="1365484.W6PYS9"/>
    <dbReference type="OMA" id="GEPCHED"/>
    <dbReference type="OrthoDB" id="2014058at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008699">
        <property type="entry name" value="NDUFB8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12840:SF1">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 8, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12840">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE ASHI SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05821">
        <property type="entry name" value="NDUF_B8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0830">Ubiquinone</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM29175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="153" mass="16996" checksum="66AAF0E0DFAAD224" modified="2014-04-16" version="1">MLSQRILARRLPQVAVRAIAPRASFSQVPALRAIEDDMALQNNNYPNPPPLKRAHRDPYGGWWDAQEKRNFGEPVHEDNEILGVFSPEQYNHVSAGKGFFHLGCFVAVFFSMVGVVSLTYPDKPSVPKAYVDGLEKELGGPNAVPAHKSGDKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>W6PZ15</accession>
    <name>W6PZ15_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PROQFM164_S01g003325</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PZ15"/>
    <dbReference type="STRING" id="1365484.W6PZ15"/>
    <dbReference type="OMA" id="CALDYVI"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
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        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF232">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="13"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="464"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="464"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="527"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM29513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="579" mass="65275" checksum="522154C45CCC980C" modified="2014-04-16" version="1">MTLSEFALLSNPTAIKVVIVACIITAVYWVLRRAYPRPLSGIPYNHHATQTIMGDLAELGERQKDIQGMRPWFLEQAHRHNSAITQLFLGPFSKPAILLSDYREVNDILSHRDAVDFKRGKKVDVFSGLLPHAHPAMETFDPRFRESRDLVRDLMAPSFLNTVNAPHTYVVACNLLELWRLKSRSANGHPFDVVNDIVEFSFDSILSAATGLGPEGGDIKRQLSYLRDMEEAGTDISLPDSMNDEVTVFPSAGTSDKLAALTLNEESLWKGFYMPWPRLYHAINNLRPSVRHSSQTLRGYIESQIKRAIPRLTKDGKPECALDYVIAREIKAAEKTGRKPVLDDPRIRDEICGYLIAGHDTSTGSLIWLMRRLLSHPEEQTKIRENLRETYSAAWAEKRLPTAAELIKHAPYLDAFLEEVLRVNCPVVTIMVQTRMDTAVLGYAVPRDTQVFLNLTGPSLNMPSVSVDESSRSKTSQMHKPARHDWDDLDPKAFLPERWLKRDAEGKLVFNAASGPTLAFSAGNRGCWGKRLGQLELRVVLTILIWSAKFDVPEKLVSWETYDSLVTAPKQCLMSMTEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W6PZ91</accession>
    <name>W6PZ91_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S01g003400</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PZ91"/>
    <dbReference type="STRING" id="1365484.W6PZ91"/>
    <dbReference type="OrthoDB" id="4138941at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM29588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="216" mass="25428" checksum="EF60487541AF6C7A" modified="2014-04-16" version="1">MSKSRFSFGYCHERAVVLEALRPELCSRSVLSEDIDQLSKSFATILTQTPWTTPEMMSLSPFEQEWYYSLLKDRLRRLDALHRIGITHGDIHFRLPDDIYDTVLYDFSASYTFSERQPFRVNRRRPRPLSRLSNGELECVLKDIQDRAASRDIRSYFIESNPGTSVDDALWQSLDKEEELLELIMLKIPHRPSPRWLFDADVEFHLPFSRSRVPKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W6PZG9</accession>
    <name>W6PZG9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Organic solute transporter Ost-alpha</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PROQFM164_S01g003247</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PZG9"/>
    <dbReference type="STRING" id="1365484.W6PZG9"/>
    <dbReference type="OMA" id="HAIYFQV"/>
    <dbReference type="OrthoDB" id="5348404at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005178">
        <property type="entry name" value="Ostalpha/TMEM184C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23423">
        <property type="entry name" value="ORGANIC SOLUTE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03619">
        <property type="entry name" value="Solute_trans_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01417">
        <property type="entry name" value="Solute_trans_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="28"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="99"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="159"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="203"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="236"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="373"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="420"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="420"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="449"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="460"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="482"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM29435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="497" mass="56506" checksum="2F95E2731BF7DA23" modified="2014-04-16" version="1">MGWPVCNTTETETIEEIALWDGGISFHLLALLVGGACAIIACLVSFALIMLHATHYSKPIEQRHIIRILFMVPVYSLVAWLSIFFYQDSVYFEVLGDCYEAFCISAFFSLMCHYIAPDLHSQKEYFRGIHPKEWLWPLNWFQKTWGGERLWRTPRSGLTWFNIVWVGVFQYCVMRVLMTIVAVVTQAFGLYCEASLSPAFSHIWTIVIESVSVTIAMYCLIQFYQQTSQDIKQYQPFLKIVSIKLVIFLSFWQSTLISLLVSEGVLASTEKIALNDFKVGLPELLINIEMAIFGILHLWAFPWECYALYNLPSEVTDFYGNGKVAYQGGRYGERALIDAMNPLDLLKAIGRSARWLFVGRKNRMLDPSYHVQDQSLGLQPPQDGRELTQHGTGTPGGVMGRYGDRPYEEDDVLLANAQSNPEISLTGTSPYASDLDEFQNPPTRFYERSPSSYDDSSPDNLQSESPIRVSSPNGPLREQFPIPIPDPYHPPPPYHHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W6PZV0</accession>
    <name>W6PZV0_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Mss4-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PROQFM164_S01g003596</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfa family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PZV0"/>
    <dbReference type="STRING" id="1365484.W6PZV0"/>
    <dbReference type="OMA" id="FKPTCHI"/>
    <dbReference type="OrthoDB" id="9970124at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1590.10">
        <property type="entry name" value="glutathione-dependent formaldehyde- activating enzyme (gfa)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006913">
        <property type="entry name" value="CENP-V/GFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337:SF40">
        <property type="entry name" value="CENP-V_GFA DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337">
        <property type="entry name" value="GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04828">
        <property type="entry name" value="GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51891">
        <property type="entry name" value="CENP_V_GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CENP-V/GFA" evidence="5">
        <location>
            <begin position="49"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDM29783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="170" mass="19449" checksum="D438029F98D734F7" modified="2014-04-16" version="1">MSEISRNFVDPLPCPARTNAIPESTPVEHWKHLPPYKVQSEEQFGPIKWRGRCFCGNITYLLKREKPLNAKYCHCPVCRVTHGAPLQWAAIFHKHDMSFTNGASGLAFYSSTHRSQKHILPTKVSCANCRTPIMDEGRNMCLIFPQLIQLEGSSQEQRKKREVFKPTHAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q0B9</accession>
    <name>W6Q0B9_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Kynureninase</fullName>
            <ecNumber evidence="5 6">3.7.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Biosynthesis of nicotinic acid protein 5</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">L-kynurenine hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">bna5-1</name>
        <name evidence="5" type="synonym">BNA5</name>
        <name evidence="7" type="ORF">PROQFM164_S01g001470</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + L-alanine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:25143"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:36559"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:58125"/>
            <dbReference type="EC" id="3.7.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>L-kynurenine + H2O = anthranilate + L-alanine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16813"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <dbReference type="ChEBI" id="CHEBI:57959"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="EC" id="3.7.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5 6">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5 6">Amino-acid degradation; L-kynurenine degradation; L-alanine and anthranilate from L-kynurenine: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5 6">Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 2/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the kynureninase family.</text>
    </comment>
    <dbReference type="EC" id="3.7.1.3" evidence="5 6"/>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q0B9"/>
    <dbReference type="STRING" id="1365484.W6Q0B9"/>
    <dbReference type="OMA" id="LPGWNSH"/>
    <dbReference type="OrthoDB" id="5978656at2759"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00329"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00334">
        <property type="reaction ID" value="UER00455"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030429">
        <property type="term" value="F:kynureninase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034354">
        <property type="term" value="P:'de novo' NAD+ biosynthetic process from L-tryptophan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043420">
        <property type="term" value="P:anthranilate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097053">
        <property type="term" value="P:L-kynurenine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:L-tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019805">
        <property type="term" value="P:quinolinate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000031">
        <property type="entry name" value="Kynureninase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01970">
        <property type="entry name" value="Kynureninase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010111">
        <property type="entry name" value="Kynureninase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01814">
        <property type="entry name" value="kynureninase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14084">
        <property type="entry name" value="KYNURENINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14084:SF0">
        <property type="entry name" value="KYNURENINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22580">
        <property type="entry name" value="KYNU_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038800">
        <property type="entry name" value="KYNU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5 6" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="4 5 6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="174"/>
            <end position="177"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="284"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="324"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="352"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="5">
        <location>
            <position position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR038800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM27659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="483" mass="54249" checksum="90F18BFCC0A8DC12" modified="2014-04-16" version="1">MGSQQHVRDIKTGSPLPYADDIRAYKKEYAEALDAQDPLRSFRDEFIIPSKNDLKRKTLAVDESNEASDEKCIYFCGNSLGVQPRSTQKYIEQYLRTWATKGVTGHFVPHDDQLLPPFVDVDTAASKLMASVVGAFQSEVAVMGTLTANLHLLMASFYRPTKEKYKIILEGKAFPSDQYAVESQLRHHNFDPKDGMVLIEPKDLDQPTLTTEQIMKVIDDNASSTALVLSAIQFYTGQYFDIERITAHAHSKGILIGWDCAHAAGNVDLQLHDWNVDFAAWCNYKYLNSGPGGIAGLFVHERHGSVDEKQPESDETFRPRLSGWWGGDIKTRFNMENKFLPQPGAAGFQLSNPSVLDINAVIASLEIFKRATMKEIRQKSINLTGYLEHLLMRYPIDAASEDKPFTLITPSNPAERGAQLSLRLQPGLLDHVLHCLEENGVVIDERKPDVVRVAPAPLYNTYTEVWQFSQIFLQACKEAVKAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2024-10-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q0G8</accession>
    <name>W6Q0G8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S01g001520</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q0G8"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM27709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="87" mass="9777" checksum="60DD4BF171EB3D80" modified="2014-04-16" version="1">MLFLVSIALHAIKGKGLRCPTRTHLILVGPAQNQSSESGDDIVLSDDLYWLVVLYFHLMVGNWDQTQARVSSISTGRRVLTMLIMDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q155</accession>
    <name>W6Q155_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Major facilitator superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PROQFM164_S01g001760</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q155"/>
    <dbReference type="STRING" id="1365484.W6Q155"/>
    <dbReference type="OMA" id="SQFFYVA"/>
    <dbReference type="OrthoDB" id="546893at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050375">
        <property type="entry name" value="MFS_TsgA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43702">
        <property type="entry name" value="L-FUCOSE-PROTON SYMPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43702:SF13">
        <property type="entry name" value="MONOSACCHARIDE TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G06630)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="171"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="201"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="414"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="453"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="483"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="509"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="582"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="626"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="669"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="701"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="724"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="758"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="786"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="5">
        <location>
            <begin position="25"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="289"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="824"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="879"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="884"/>
            <end position="903"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDM27949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="916" mass="100097" checksum="2121E73D1D3EE421" modified="2014-04-16" version="1">MEGRQQATLGVSITLFSIASLFVALRFISRIFVVRKIGLHDWLMLVAWFIDFGFSFSLFYAVRKGLGLHSSDIKPEDELAFNTANYAFTVLYNPALMAVKTSILVFFLTLTRNQKVFRCANYVTLFVVNAAGFALTLVNVFQCRPLSAVFLSDIPAHASCTDIVTLYLSSSPVNIITDLAILLLPMPLLTTMRLPYKQKIILVVTFSFGFFVAVVDVVRIAFLQQAAISRSLEVKSIHIQNIGGVDFSWYASLSFMWSVVEVNISIICGCVPSLKPLVTRLVPKLIRDTGDETSTASPHGLSAGPTGESQVAVPPPAAVSGSPEFQLPLPFPSNNNGDKGLRNQVGGVSTGRPSSRDSEPMGIMDFLGIPETGALDTEGGTNTSASYAPDITFFDFVNMKNPESMLKLNNRESITPIALTTLLFFLWGFAYGLLDILNSQFETIVNLGPWHSLGLHGAYFGGYVVGPLLVGRPVLKIWGFKSTFITGLCIYACGTLIFWPSAVLTSTPAFILSNFIVGFGLAVLETAANPFIALCGPLENSEIRLNISQGVQAIGSVLSPLLAKRVLFKNVQDVASLVDVQWAYLGIALFDVLLAVAFYYLPIPEASDEDLEELANRRREDNMTKVIGIPVVWLTLGLGVWSQFFYVAGQEVVATALQRFVLAARPDSSLKPFDFLTIGHSIFAVGRFFAAFAQWFLKPRWILMVSYIGMIVCSILCMKTSGTGAIVMVMLVYLFESGAFSIIFAISLRGTAQHTKTAAVFMTAAIGGGTFFPFAEYAAYLAHGGSYSFCVIVALFCAGAIFPIYLNLVPAVKKQVDPVPNEYLRRHRRRPRTSIETVHREKSNPSLGGVLSHPRSLASNPDHLPDLLLPEEMHENSLARDFSGAKSSFSSTSRAKSNSSRNSGSKKKFSTRIDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q1E2</accession>
    <name>W6Q1E2_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S02g000507</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q1E2"/>
    <dbReference type="OMA" id="YVNFAVY"/>
    <dbReference type="OrthoDB" id="4309089at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="256"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM30358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="277" mass="30171" checksum="47BC99422E33051F" modified="2014-04-16" version="1">MAFSQLLTAFEPYIDIPFNVWLTIILILTYGCAVRNPGLLLLVVLGVSATILIFNTTATLGEMTKTMCLLPLGLGSVLSFLAADRSLQTKFLSAFTTYVNFAVYANIGMMVGTPTGGTLRGMCSKITCVALFVWIVQKGHRVGWKTVRVHENLFVFTAVSKSWIFAHACYRFVLLTLPCFGSGRRYRLLELYSLALTFALSSTSKLPFEYFFGMADTLVVPAISGWSAIATTFNLIPRYTVNDDFLSSSIGPGTDAFLSAVSLAVAAFACFKMASAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q1K9</accession>
    <name>W6Q1K9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ankyrin repeat-containing domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S02g000577</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q1K9"/>
    <dbReference type="STRING" id="1365484.W6Q1K9"/>
    <dbReference type="OMA" id="WAVAYNR"/>
    <dbReference type="OrthoDB" id="539213at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0085020">
        <property type="term" value="P:protein K6-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171:SF11">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="72"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="108"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="141"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="175"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM30428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="237" mass="25540" checksum="7F11F8D5B417C13C" modified="2014-04-16" version="1">MDSDQKFPLHEAAREGRNEVVESLLNANPKSAYVKDDDERLPIHWAVAYNRHPVVELLVAMKDFDPDVEDGSGWTPLMIAASLKDAAGDATIDLLLRKGADVSIKSHTGQNALHFASSKANLSTVRTLLANKCSARVKDKRGQLPLHRAAAVGSVPILKLLLEEGKSPVNATDGDGLTALHHAISEGHGPAAIFLLKSGAEAAKRDNEGRLAIQLVPDDKVKQYILQTAEKEGIELP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q1Y7</accession>
    <name>W6Q1Y7_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF155 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S02g000712</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RMD1/sif2 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q1Y7"/>
    <dbReference type="OMA" id="QGLYQTK"/>
    <dbReference type="OrthoDB" id="242766at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070131">
        <property type="term" value="P:positive regulation of mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003734">
        <property type="entry name" value="DUF155"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051624">
        <property type="entry name" value="RMD1/Sad1-interacting"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16255">
        <property type="entry name" value="REQUIRED FOR MEIOTIC NUCLEAR DIVISION PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16255:SF1">
        <property type="entry name" value="REQUIRED FOR MEIOTIC NUCLEAR DIVISION PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02582">
        <property type="entry name" value="DUF155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF155" evidence="3">
        <location>
            <begin position="178"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="48"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM30563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="431" mass="48447" checksum="E017DB1A2441832E" modified="2014-04-16" version="1">MFARPYVCLNCCRRPISQFPTRPQTQFLHASPRLALPRRKDFFSSNAHLKQKQNADEPIESSPDSRKQLRRGPRSPAAPTSLRRVAVEAQRSKDGIISKALLKEQGLYRTKTVTAYAVAEQFDIRKVRDILQERGYEPDPLETGLFPQVVHVQIPLDSIQRMTNPSGIDPPSDEVGDLFVFPSGTVVAWGLPEGFTSFLATRTLLPAAQGAHVDNLETEDLEFVEDPKRENSVIKGDTIILGTKPGHGDAEGLPAAQQSINTVLTKIAFSSGLARSTKLAVLESLLSNYFESTRPIPTLLSKGSRLPFTRDFVLRKTGQLLSVRAQLNLYSELTDSLPDLFWDSRHELGLEGYYEQAGRALDVGIRIKLLNEKMDYAQEIASVLRERLSETHGLRLEWIIILLITVEVGFEVLRLWKERAHKQEEARKQEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2024-10-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q296</accession>
    <name>W6Q296_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S01g002120</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q296"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM28309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="43" mass="4884" checksum="6DA60BD21C0180BF" modified="2014-04-16" version="1">MFIQDILYKGSRLVKVRFAGYPGRDIPPVPPPLRSTHLCAYPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2024-10-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q390</accession>
    <name>W6Q390_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S02g000590</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q390"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM30441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="127" mass="14109" checksum="878CF6B40EB54A5D" modified="2014-04-16" version="1">MTLPEPRSASVVEASAVAYVHGTEPPSSTGIPNPLSSLMQSRLRPHIISSIILCVRWTSPACGWLGRMNSSRSGSGIHAYGSRTLIQHGMVETWSISLGEFIFEDFALPPEYKWKDRHFLHARTTCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q3E8</accession>
    <name>W6Q3E8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Major facilitator superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PROQFM164_S02g000980</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q3E8"/>
    <dbReference type="STRING" id="1365484.W6Q3E8"/>
    <dbReference type="OMA" id="TTPACYN"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17327">
        <property type="entry name" value="MFS_FEN2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000934">
        <property type="entry name" value="Allantoate permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000064">
        <property type="entry name" value="MFS allantoate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF70">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="121"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="149"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="183"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="211"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="318"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="349"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="375"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="410"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="442"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="54"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDM30830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="504" mass="55705" checksum="C89A7BB43FF597CB" modified="2014-04-16" version="1">MASQKEAEVSVSPPISSTTSSERDENYEFYKQHHGLEYTAQEAKKVLRKIDIRLIPSLFLIYMLQYLDKNSINFASVYGLKQGTHLKGQQYSWLSSIFYFGYLIAQYPAGLALQKLPVGKFLAITTLVWGGLLMTTPACYNFAGIAINRFLLGMIEAVVTPGFVLMTGMWYTSEEQPLRLASWYCTNGIATMFGGLIGYAVGHITTGLPRWMYVFLIFGAFSIATGVFALILLPDLPSTAKFLSERERAIAVERVAINRQGVKSSQFKWYQVRQAAQDPKTWLLFIMAIGAQVPNSALTSFTSIIVGTFGFDTLGTQYLQIPGGAVQFVSLLLGGYIATKFDGKFHSRFTCMIFACTICILGAGLLVGLPSSNKWGRLVALWLCYFQGLGFSMSLTIVSSNIAGYTKKQVTGALLFTGYCVGNIIGPQTFKSSEAPGYSSAYIAMLAGYSVKLACIVALYIYMYLENKRRDREAINGQEVEAEGVENGMLDKTEIDNKGFRYVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q3U5</accession>
    <name>W6Q3U5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AAA+ ATPase domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S02g000796</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q3U5"/>
    <dbReference type="STRING" id="1365484.W6Q3U5"/>
    <dbReference type="OMA" id="VRYYMRL"/>
    <dbReference type="OrthoDB" id="10255969at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050334">
        <property type="entry name" value="Molybdenum_import_ModC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43514">
        <property type="entry name" value="ABC TRANSPORTER I FAMILY MEMBER 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43514:SF4">
        <property type="entry name" value="ABC TRANSPORTER I FAMILY MEMBER 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="3">
        <location>
            <begin position="94"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="3">
        <location>
            <begin position="377"/>
            <end position="672"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM30646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="730" mass="81947" checksum="71518541ED5536BA" modified="2014-04-16" version="1">MATMLLRTKLRPRALRLTAYRPTRFKSEIPFLRIEDGTFYKKYPTSEDTSNPPLFPNLNFTLPAIYVNGATKEAPPQHWAIIGPAGRTDLLHILRGQHICIPPKARSYPYLLTDEIAEKDPRLRVIENAVQYVGFSGEGSGAIGGVRGAYLSARYESHREETDWTVLQYLRGQTSLNPMEGDENGTLHDELSLQRTIESLELGNLLLLPVSSLSNGQTRRARIAKAILSKPELLLLDEPFMGLDPVAVRKISNLLHELAKKSAPRLILALRPQDKVPDWITHIMVLGNDHKVLLQGPKPAIEDTLNVWSYVANKSKPDSLPDQQAEILEKCTADLKAGVLDKELLGDLVAHTNEIKSTEVHAPLGGEPVIDMEGVHVKYGDKVVLGNWQQNVNGEAKDGLHWRVRRGQRWAILGPNGSGKTTLLSMVTSDHPQAYAQPVKLFGRSRLPEPGKPGISIFELQSRIGHSSPEIHAFFPRQLSIRAALESAFAETFLSKPKLNIQRDQDISAVLQFFQPYLDPNYAPGEVPKISTAGLPSLTKRTHVKLGTYALMDHIVGYADEILFSELTTAQQRIVLFLRAIVAKPDIVILDEAFSGLSAAQRNACLHFLENGERPKRRALNVQARSSKESEFRFTGLTEDQALIMTSHVADEIPDSVRYYMRLPSPPGTFNPLDFRFGILQSKTTLRHPQTWEAAWSPPDAFIKHARRTWRRKQHTLPVQDMTEFEWWSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q3W8</accession>
    <name>W6Q3W8_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PROQFM164_S01g002625</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q3W8"/>
    <dbReference type="STRING" id="1365484.W6Q3W8"/>
    <dbReference type="OMA" id="GMTCKLA"/>
    <dbReference type="OrthoDB" id="541276at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007095">
        <property type="term" value="P:mitotic G2 DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13993">
        <property type="entry name" value="STKc_Pat1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000549">
        <property type="entry name" value="Protein serine/threonine kinase (Ran1), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43895">
        <property type="entry name" value="CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43895:SF32">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE CHK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="32"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDM28814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="412" mass="46057" checksum="9A601EB3A9933327" modified="2014-04-16" version="1">MYPAMLPTPPPSPVPRRYAPEDRLGLVLANRLELTRVLGVGAYGVVYTAVDIHTNEVYAVKVLCKDGLDARQLKFQQREIRLHHLASQHRNVVPLVRIMDSVDCTYVVMEYCPEGDLFSNITDKGNFVGNDFLAKSVFLQILDAVQFCHTLGIYHRDLKPENVLVTENGMTVKLADFGLATTDYYTTDFGCGSTFYMSPECQQANARPLSCYMSAANDVWSLGVILVNLTCGRNPWKRASIEDSTFQAYLKDPFFLKTILPLSSEMVSILSRVFEIDPMKRISIPELRQLILECPRFTENPMVPTPWVPEQIDYIPQPQMPLFMAPMEPLYAQTSGSSLDSAQYSAFSQSAASVGSAITEDYSDFDTMSPAVSQQIPDYKGFPSVCAEPFFPADPFSYGLMHPNLQGLEISV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q484</accession>
    <name>W6Q484_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Beta-lactamase/transpeptidase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S01g002780</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q484"/>
    <dbReference type="STRING" id="1365484.W6Q484"/>
    <dbReference type="OrthoDB" id="5946976at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052907">
        <property type="entry name" value="Beta-lactamase/esterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43319">
        <property type="entry name" value="BETA-LACTAMASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43319:SF3">
        <property type="entry name" value="BETA-LACTAMASE-RELATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM28969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="85" mass="9381" checksum="C0A59AC307318DB0" modified="2014-04-16" version="1">MVLYLNIRFGLGVALPEVITFIPEGNICFWRGLGGSMMVMDLDRRMTIGYAMNKMGPGAMGNANAKAYIDAIYEIMADKKRSVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q4C7</accession>
    <name>W6Q4C7_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S02g001628</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q4C7"/>
    <dbReference type="STRING" id="1365484.W6Q4C7"/>
    <dbReference type="OMA" id="GYACEFV"/>
    <dbReference type="OrthoDB" id="310870at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052971">
        <property type="entry name" value="TRP_calcium_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056336">
        <property type="entry name" value="YVC1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35859:SF5">
        <property type="entry name" value="ION TRANSPORT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35859">
        <property type="entry name" value="NONSELECTIVE CATION CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23317">
        <property type="entry name" value="YVC1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="270"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="331"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="362"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="396"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="431"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="455"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="Calcium channel YVC1-like C-terminal transmembrane" evidence="3">
        <location>
            <begin position="276"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="574"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="586"/>
            <end position="597"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM31478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="652" mass="73808" checksum="6F364E5EDE58CD22" modified="2014-04-16" version="1">MDKTMDHTEIPVIEIDEPLFDVLPKLFNFISMAVGDMAYTFEQMLYGAQGHRLRQLVHALADDTHNPYIIVALMILKWDFTTATEDDWGLNESRGAACEFVAWQFLCHLNQRETIEFLLEELPIPRRGSTNTLGSEAGSPALASIQGRQEESETTPLLPKSSSFYRLFSSRRVTETRLSGASQDTYQEETYAAQRYSRFFGLNALEIATIANAKTFLSQKVVQKVVDGIWKGEIVFWGSLTVNSTKKPHIFNARTADPYSRLRVPLYRKIFEAAFFMSFLFLYYAVLIERRQDAVGVFEAVMYVWIVAFAYDELSGIIDAGVIFYQMDFWSLWNVSIIGVGIAFVVTRVIGLTKGDNDIIELSFDILSLEALICSLVSLNSYFGSLIPVLKEMTKAFFRFFPVVVVLYIGFLTTFTMLARDRLSLSTMSHLLVKVFFGSSVLGLVGSHISPIFGYGLMLTFALMTNTLILSSLISLMSMSLEGVMRHAREEYLFQLAIYVLESSNSRRLTYFMPPLNLIPLLCIRPMRLFLSAGTVRRVRIVLLRATHLPFVALIWAYESKWRHLKRTTIQLPPMSARGQGTSEPTESRCRDPHHPSVVETNRLGPGKAPSVDQQAVRELEMGQVGQVPQLADLIDTIERLRTQVEAIAQQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q5B5</accession>
    <name>W6Q5B5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S02g001984</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q5B5"/>
    <dbReference type="OMA" id="CYLYNGF"/>
    <dbReference type="OrthoDB" id="4338083at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004881804" evidence="1">
        <location>
            <begin position="20"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM31833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="152" mass="16556" checksum="FE0EEFF235566144" modified="2014-04-16" version="1">MKFLTCLTLISVAPWTVNALPNPEDLTVLAYRAWDFRFLSVAPPACNSSVNNIQYSILHYSGARALDCQGLDTTYYNSTNVKSLSWKSPSDVNRYDLCMFSSSDCSGGADSLLGSITSGWDVCYLYNGFESWTVVPNGSACVSDAGDDEGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q5V6</accession>
    <name>W6Q5V6_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">General negative regulator of transcription subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PROQFM164_S02g002224</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Acts as component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover. The NOT protein subcomplex negatively regulates the basal and activated transcription of many genes. Preferentially affects TC-type TATA element-dependent transcription. Could directly or indirectly inhibit component(s) of the general transcription machinery.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the CNOT2/3/5 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q5V6"/>
    <dbReference type="STRING" id="1365484.W6Q5V6"/>
    <dbReference type="OMA" id="YKPQTPY"/>
    <dbReference type="OrthoDB" id="293823at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030015">
        <property type="term" value="C:CCR4-NOT core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.1020:FF:000006">
        <property type="entry name" value="CCR4-NOT transcription complex, subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CCR4-NOT complex subunit 2/3/5, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038635">
        <property type="entry name" value="CCR4-NOT_su2/3/5_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012270">
        <property type="entry name" value="CCR4-NOT_su3/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040168">
        <property type="entry name" value="Not2/3/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007282">
        <property type="entry name" value="NOT2/3/5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007207">
        <property type="entry name" value="Not_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23326">
        <property type="entry name" value="CCR4 NOT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04153">
        <property type="entry name" value="NOT2_3_5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04065">
        <property type="entry name" value="Not3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005290">
        <property type="entry name" value="NOT_su_3_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0010">Activator</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0678">Repressor</keyword>
    <keyword evidence="8 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 10" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="CCR4-Not complex component Not N-terminal" evidence="13">
        <location>
            <begin position="3"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="NOT2/NOT3/NOT5 C-terminal" evidence="14">
        <location>
            <begin position="463"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="241"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="401"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="124"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF04153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CDM32073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="596" mass="67015" checksum="F3F1A46B84D52BB5" modified="2014-04-16" version="1">MAARKTQQEIEKTFKKVSEGIQTFEGIYEKIRQATNPTQRDKLEDHLKREIKKLQRFRDQIKSWAAGNEVKDKAPLMEQRKAIEVCMEQFKAVEKEMKTKAYSKEGLSAASRLDPKEKERVECSEFLSTMVDELQLKIEALEAEEETLHAQMKKGKKDTKKADRLADISHITERHKWHVNKLEFLNRSLQNGNLDVGAVQDLKESIKYYVEEGGSLDYSGEDETLYDDLNIGEEIEAQFGMGGEGDRVSSQDAQSIQDEEPEPKPKVKQEAPAARRPSTQMKSPLPVLATLHPSASSSAPGMKPAPLPTRPPGETLKYASAAAAAAASDKSGVGILPLPPPPGFSPALSVALPISKSSTASPSVASVQPVMKSIIPPTVAAVTEELAGHVRPKVPVSASVLSPAPAKAETSTNGKLETEETESEESIYHLPPGLQDLLQSFEVTKSRASANPSPSVQRLLATSLTTCPEAGDAEKPRHYKPQNPYSTALYYPQEPLPIFDDPRLYDTGRIDTDTLFYLFYYRQGTYQQYLAAKALRNQSWRFHKQYQTWFQRHEEPKNITEEFEQGTYRFFDYESTWMNRRKADFKFVYKYLEDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q5W0</accession>
    <name>W6Q5W0_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Inheritance of peroxisomes protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PROQFM164_S02g002229</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for peroxisome inheritance.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Peroxisome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the INP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q5W0"/>
    <dbReference type="STRING" id="1365484.W6Q5W0"/>
    <dbReference type="OMA" id="PYETEEH"/>
    <dbReference type="OrthoDB" id="4097008at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005780">
        <property type="term" value="C:extrinsic component of intraperoxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045033">
        <property type="term" value="P:peroxisome inheritance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024758">
        <property type="entry name" value="Inp1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12634">
        <property type="entry name" value="Inp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="165"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="235"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="431"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="537"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="579"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="646"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="432"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="537"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="579"/>
            <end position="594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM32078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="700" mass="76555" checksum="56CCB67205EA6910" modified="2014-04-16" version="1">MNHARVSNVPNTPEHVIFYHPSAKIVHFSPRALAPIPSSSTPSDFDYPVDTIETLPWRSATERTVATAPLRLEKVHGSTAFLKCGNVVHAILKNSQCWCVDGVSKFVLRIRPLTYYRIEIPYETEEHRSLVRDLKIALPTVLRYEVTPCPFKRSFSVELPNDAMAPRRKKAWQPKDQRERVPTVLEPPRETPSPSSIRSDCLDSASAGDDTDGDLTDDSCFTSNKASSTILETIPDDRASSPVEALSPSPYQGPPRRSVTEVPQTFTSLLAKFEATSGADDEYDIDPLLKPECASSTDAALQIDHELKVTDQLEPEFVADSGVEAGPESEAVLDSEIKAEAELEIKSELLLEAISPAEPFKESAVEAEPSIPIETDAVLAAETSDEVVFRAETTSAVGTKAVLEDNLVNVEEVQRVQPTAKLTLEVDHDASFASSPESFHSAEPQSPDSVSTHPTSVGGPDLPESEEISNLSSIKHIISGLEASADQCKMPQPPTLGIPQSDNVPNPTSLLHPPSMHSISSNNVPRRFADAFADTSPSMAPTNNGHRPSRFTDVSADTEPRPNIRAKVAALNTDLDHMSSEFRRRAKATRERDVSPMPHSSALYQPSSDGSSFISKAITLVLIPPAYLFVILLHIAARIVIHPTIQPTISSPPSEPNSHSQPKKKDPATEDDFSFPLEPQTSSEYEDAELFRKLDPWDLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q772</accession>
    <name>W6Q772_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S02g002729</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q772"/>
    <dbReference type="OrthoDB" id="4290543at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM32578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="68" mass="7774" checksum="4C8D37AF0E07F8A9" modified="2014-04-16" version="1">MSILKLVDNSASPKPCQLLYGMKSWLIIELPDGQIFIYYSYLDTPLPLREDMLVGRDIPVFCAPVRQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q7A4</accession>
    <name>W6Q7A4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Zinc finger, C2H2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PROQFM164_S02g000293</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q7A4"/>
    <dbReference type="STRING" id="1365484.W6Q7A4"/>
    <dbReference type="OMA" id="HASIKDF"/>
    <dbReference type="OrthoDB" id="1577640at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054471">
        <property type="entry name" value="GPIID_WHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058925">
        <property type="entry name" value="zf-C2H2_AcuF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF16">
        <property type="entry name" value="GPI INOSITOL-DEACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22939">
        <property type="entry name" value="WHD_GPIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26082">
        <property type="entry name" value="zf-C2H2_AcuF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="695"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="4">
        <location>
            <begin position="1004"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="4">
        <location>
            <begin position="1076"/>
            <end position="1096"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="775"/>
            <end position="799"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDM30144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="1131" mass="127816" checksum="8B7669811F085D5D" modified="2014-04-16" version="1">MADPISITSLIIDISSIIPRLIAYAKGVRDASSDIRRLSEELFALKGILEHLHSEVEPPRPTKLGPLSLITPEPLMSILQKTNESLQVLLSDIKEPANKFKRVKQKLEWPFTQEQLNTHLTRLERVKSWLILVITSDSNSLQRDLHSEITSLAKSLEQDLKVRNDEMIRTAHEELSRWLAPVSPSSIHLQASNLRANHTGKWFIDGILNDWLWNDGTHRSIFVLLGKLVIELTFYSAHTVDELVRMSSNDHRLVFAYFYCKFDDTAFQEPVNILGSLLVQLSESIPSVLESIWPLFKATTKSSAYRRPIDIGAIEDAIIKISSGGKRVILLIDAINESVYKEIIIRSLLKISNLAPNLRILITGTANLIPGQHANVIHMNAEIVRDDIDVFIRFRLQQDETLRNLSTRLQDQIWTTILEGADGSFRWTQLSLETLGSLRTAKSIREALQTLPKTLRETYIHILERIPPSDWELSRNALFWLSFSKRSLTLPELSEAVILEKTCTYLDDDLRLVSPQILLDICQGLITQDEFRNVKLSHASIKDFLTSEWIRSSSVRYFSLNHETADQIIMRLSLTYLCLDNFLSGYTSSIDSIASREHEHPFLEYAAQFWATHGGSCSFDDRDYQLVNKFFNSQYLPRRGNFGVWVQALIPEVPTVAIETTNPLYYAASFGLVPIVKAILASVLSAEVDAPGGRYGSTPLFAACWRGNYETAELLLQAGADPYIVDTNSGLTIFSLPKSAEFSRLLATLHKGLENTAIGPGVKGKANIGECANPGPYSGQIPQHTARGNDTEGTEDNDSDIRSLVENPGLAMDFLAVSPLIDPTVEGFKKHILHLYPRLEPALVHRFASEQLRRYNVLVNFQRNHIDAVTNRSCRSGEYCFALGGGESSLQLPKDPSGLLQGMDVSRNSDRLSDMGETAAPVAEFPPAVPIPPVSLFPSQFECPICFQVKKFLKPSHWSKHVQADLQPFTCTFSDCSEDKSFKRKADWVRHETERRRQSEWWVCSYSDCSKKCFRKDNFVQHLVREHKMLEPKVKKSNDLTSERHSEVQRDLDIDRLWEIVEQCRQEIKQTSQESCRFCGNTFDNWKKLVVHMSKHLENLAMSVLGLVQQNGASDGFPLYQAGIAGRPSCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q7K9</accession>
    <name>W6Q7K9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Peptidoglycan-binding lysin domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PROQFM164_S02g002869</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q7K9"/>
    <dbReference type="STRING" id="1365484.W6Q7K9"/>
    <dbReference type="OMA" id="DYYICVH"/>
    <dbReference type="OrthoDB" id="5985073at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052210">
        <property type="entry name" value="LysM1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34997">
        <property type="entry name" value="AM15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34997:SF18">
        <property type="entry name" value="LYSM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004881342" evidence="3">
        <location>
            <begin position="19"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="4">
        <location>
            <begin position="30"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="4">
        <location>
            <begin position="111"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="4">
        <location>
            <begin position="179"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDM32718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="227" mass="24463" checksum="784655C108E8C48E" modified="2014-04-16" version="1">MHFPQLLVAGLVPAVASARALSRRAVDCSFTTSPSSGDKCDSFASSWGLTVDDLKAMNPGISCPNLDTSKFYCVIGTVTGEPEPTTTTTTTTAPTVTNEPAMPGIVDDCDGFYKVSPGDECDTIATEHGISKAQFLEWNTSVNDQCSNLWLDYYVCVHVPGAATGPQPQMPGIISSCQKFYKVKSGDSCYTILQESGTDLSNFRKWNTKIDASCSNLWVDYYVCVSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q8A5</accession>
    <name>W6Q8A5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Exodeoxyribonuclease III xth</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PROQFM164_S02g002362</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q8A5"/>
    <dbReference type="STRING" id="1365484.W6Q8A5"/>
    <dbReference type="OMA" id="WFWTCAQ"/>
    <dbReference type="OrthoDB" id="430051at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010666">
        <property type="entry name" value="Znf_GRF"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51999">
        <property type="entry name" value="ZF_GRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GRF-type" evidence="7">
        <location>
            <begin position="29"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="165"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="299"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="191"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM32211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="333" mass="37575" checksum="E5365671509B225E" modified="2014-04-16" version="1">MSYPQIYQGSPRTTSRQNRGLFRDGLWCCNCADRPVAVRRETKRHGPNLGKWFWTCAQSRCSFFLWAADAVIREQAVVLANSRSETDSFSITPSKRTPGRMNNGLITPQTERKFIDTPQRNFKSPPKTAKARMISEASDDFGWNDDSDDDELIKALSSSQTETFISQPNFHPDSPFKTPRTAAVTSPGKRKLGEITNDKSSYDRSAPATPFSSRSSRTEMFPSSAELCMTPTPSKYNDVLSADSNFDTSDLAKSLLDILEKHSVVLPNRAHDEVLSLLNRQDLKTRGIIRGRDMTRLALKKKDGEIKKLQDRVSNLEAQRELDRSLIEGMKPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q8H5</accession>
    <name>W6Q8H5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S02g003144</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q8H5"/>
    <dbReference type="STRING" id="1365484.W6Q8H5"/>
    <dbReference type="OrthoDB" id="4357582at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM32993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="169" mass="19731" checksum="114717CBBD511B12" modified="2014-04-16" version="1">MVYNTSSAIRTKSAPIDTYSTALFNFNHYKYYLDNLNPQCGLLTFRSTLITLGFCPFYLGDKRSAVSLATVFCPHLYCEERKYINNLYLQWHFFDIHSIEEPQSNCIKRKRKWQLQSEPAGTTFRNLSNETLPSLEDYFLTNTLPTSFKDSDITSADNLFMEFIHLDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q8R6</accession>
    <name>W6Q8R6_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phytanoyl-CoA dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S02g002532</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q8R6"/>
    <dbReference type="OMA" id="TWGPADW"/>
    <dbReference type="OrthoDB" id="445007at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31630:SF6">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31630">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM32381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="326" mass="37455" checksum="36A364248106D45B" modified="2014-04-16" version="1">MPHPTTNQVTVDDSRVHGDWRDELFQNGYVVVKNAISPDRCEYYIDKMFEWLESFPFGFDRNDRSTWTEQHLPTHIKGGMYHGYRIQHEKFIWEARTEDGVIEAFAKLWGTDKLLVSFDGVNFTLPSGTTLPQTKPWPHIDQSPLRQGMQCVQGVLNFAPNGPQDGGLLVVKGSTKLMPEFFKTHSGEIGRETWGPSDWFGFDESEVKWFEERGCEILKVNAEAGDLILWDSRTMHFNCVPSSQNLRAVVYACYTPASFATPDVLQKKSEFFDQRIGTTHWPHDNLFTETSHANRPEEDEGDLTKRLYEEPVETDLVLKLAGKKPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q8Z5</accession>
    <name>W6Q8Z5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Probable transposable element</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g000036</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q8Z5"/>
    <dbReference type="STRING" id="1365484.W6Q8Z5"/>
    <dbReference type="OrthoDB" id="3261222at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM26227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="143" mass="15884" checksum="7126ED5CC6B3EAC7" modified="2014-04-16" version="1">MLQCTHTHRSNTSFFLGGKPPSDDQKWKPNLEAVRASIRFAIATADLRPLNLANECEQTVKHKRSSTNGQAQTVKHKWSSTNGQAQTVKHKRSSTNGQAQSVKNSRFRINKDVSGEVMNGRTKGRCPNNIQKLSSILILALTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q930</accession>
    <name>W6Q930_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA(Ile)-lysidine synthetase</fullName>
            <ecNumber evidence="1">6.3.4.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PROQFM164_S02g000879</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>cytidine(34) in tRNA(Ile2) + L-lysine + ATP = lysidine(34) in tRNA(Ile2) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:43744"/>
            <dbReference type="Rhea" id="RHEA-COMP:10625"/>
            <dbReference type="Rhea" id="RHEA-COMP:10670"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="ChEBI" id="CHEBI:83665"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.4.19"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="6.3.4.19" evidence="1"/>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q930"/>
    <dbReference type="STRING" id="1365484.W6Q930"/>
    <dbReference type="OMA" id="ARIPECH"/>
    <dbReference type="OrthoDB" id="434144at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032267">
        <property type="term" value="F:tRNA(Ile)-lysidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01992">
        <property type="entry name" value="TilS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01161">
        <property type="entry name" value="tRNA_Ile_lys_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011063">
        <property type="entry name" value="TilS/TtcA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012094">
        <property type="entry name" value="tRNA_Ile_lys_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012795">
        <property type="entry name" value="tRNA_Ile_lys_synt_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43033">
        <property type="entry name" value="TRNA(ILE)-LYSIDINE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43033:SF1">
        <property type="entry name" value="TRNA(ILE)-LYSIDINE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01171">
        <property type="entry name" value="ATP_bind_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal" evidence="7">
        <location>
            <begin position="51"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM30729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="686" mass="76606" checksum="63DA351E707D5D57" modified="2014-04-16" version="1">MAGNISISPVLFQRCFQQAWSRSRRARLNYGSAKYGKNPGDNDTLQLPRKFGIAVSGGADSMALAYLCKQLEQSYDVAGAISVTAFVVDHRSRPESTMEAQKVAGWLRDMDIRTHILNLDWSEIISSQNQLSPKPGASGPLPSAFETHARRLRFQALGIACYEFELETLLLGHHQDDNIETTILRLSAGATGLGLGGIPEVARIPECHGIFGASESWSTTSIPIKRPTKPQAKVRFYNQTHGHITSPDPTARTGNTHTNLISNVKMASPGIFVCRPLLSFAKTSLLETCHKNQVPYVSDPTNFDPTLTPRNAIRSLRTSNSLPRALESQSILSLLRSSQDLLQRSNELSNYLLSSQCRMLDFNPKAGSAVIQFLDKTPASMDPQLATLSASRIRQIQTIVLRRMTELVSPFPDSHFSLRRYEPLVHNVFPGLDGSHGASATSNDEKRRKGFTVAGVLFQRLPNEASRLGKSHDPRLGGDNIWLLSRQPFMKNRDPVTQVNVSPSGSFTPWVLWDNRYWMRLRLVPVDRDPNELADELISLPVTIRPFNKIDIERIRKDAANLRPRGQTNKDFTAGQEMPGTFEHVKALLSAEAPAQLRFTLPVLSREGIVSKPGKPPSQKVWQKLALPTLDYRLSGHSAKHSSLNEVEVVHLRCRWKLKWQWMYKMIDTEALCLMGWPVGKDAEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q9L5</accession>
    <name>W6Q9L5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S02g003257</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM33105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q9L5"/>
    <dbReference type="OMA" id="CMYGFLS"/>
    <dbReference type="OrthoDB" id="3796275at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="259"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="259"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM33105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="280" mass="31276" checksum="870BE71EF3436907" modified="2014-04-16" version="1">MAQIITLVARELLLETLPPLLVGPNHTNSSAIHKVDFVGQLMPWPNFEREVIAALSSPSTNWSTDTLDVRIVGPGAENSMSVEQLVLGDETGLQGRLNERLGRPVTASLQAQHHHLRAADFKASAAAAAGYTRVPDMVMLNDVSAIKVIGEVKTPWPGAHCDMLSMGVQDFEIAHGKLFRRRLGQVSRYMKELNTKHAFLSTYDKTIFLRKVDIGGVWTLQFSPVIQYDRPYNPQTETITAQQGLFYLALLRQSEPAFTTRASTRAPQRNQKWTVSRERQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q9R7</accession>
    <name>W6Q9R7_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Proline dehydrogenase</fullName>
            <ecNumber evidence="2 5">1.5.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PROQFM164_S03g000112</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Converts proline to delta-1-pyrroline-5-carboxylate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-proline + a quinone = (S)-1-pyrroline-5-carboxylate + a quinol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23784"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17388"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.5.5.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the proline oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.5.5.2" evidence="2 5"/>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q9R7"/>
    <dbReference type="STRING" id="1365484.W6Q9R7"/>
    <dbReference type="OMA" id="AESQHYQ"/>
    <dbReference type="OrthoDB" id="5464at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004657">
        <property type="term" value="F:proline dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010133">
        <property type="term" value="P:L-proline catabolic process to L-glutamate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029041">
        <property type="entry name" value="FAD-linked_oxidoreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002872">
        <property type="entry name" value="Proline_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015659">
        <property type="entry name" value="Proline_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13914:SF0">
        <property type="entry name" value="PROLINE DEHYDROGENASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13914">
        <property type="entry name" value="PROLINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01619">
        <property type="entry name" value="Pro_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51730">
        <property type="entry name" value="FAD-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 5" id="KW-0642">Proline metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proline dehydrogenase" evidence="6">
        <location>
            <begin position="124"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM33388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="476" mass="52607" checksum="CB9310BD2620EEF4" modified="2014-04-16" version="1">MRTLFPGKPVTGLARCIRTSNVPASTRLRFSSTLQAQAQVKTDPSPSLPPLSILPAHVLLRSLLVSTISSKRFLLIPALSFMSFLSKPNRIWLFDVDRNPILHGILKKTFYNQFCAGENAAECRSTIREMKDMGFRGVILTYAAETVFDHSTQAQHGQGVAALKSEDGNVSINAPVSQCPSIEAWRKGTVETIDMSDAEDYLAVKLTGAGIKATEAFAAGDLPPQQMMDALDEICTKAKDRKVRILVDAESQHFQKGIARVAVELMRKYNRDGYATIYSTYQAYLKSTPATLANHLTVASEDGFTLGLKLVRGAYMATDERSLIHDTKEDTDNAYNMIAQGALRKNIGEFGDKGSREFPSVNLFLASHNKESVVAAQKLYKHRVTSGLPTVPVRFAQLHGMSDEVSFTLLQMNDGDGTPEVYKCSTWGDMGECLAYLLRRAIENRDAVLRTDNEYRALKAEVFRRAKLTFSLSPSS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2018-06-20" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q9S9</accession>
    <name>FGOX3_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Chanoclavine-I aldehyde reductase fgaOx3</fullName>
            <ecNumber evidence="4">1.3.1.100</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Isofumigaclavine biosynthesis protein fgaOx3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Old yellow enzyme homolog fgaOx3</fullName>
            <shortName evidence="5">OYE fgaOx3</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">fgaOx3</name>
        <name type="ORF">PROQFM164_S03g000127</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>FM164</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2017" name="Appl. Microbiol. Biotechnol." volume="101" first="6111" last="6121">
            <title>Silencing of a second dimethylallyltryptophan synthase of Penicillium roqueforti reveals a novel clavine alkaloid gene cluster.</title>
            <authorList>
                <person name="Fernandez-Bodega A."/>
                <person name="Alvarez-Alvarez R."/>
                <person name="Liras P."/>
                <person name="Martin J.F."/>
            </authorList>
            <dbReference type="PubMed" id="28620689"/>
            <dbReference type="DOI" id="10.1007/s00253-017-8366-6"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2017" name="Org. Biomol. Chem." volume="15" first="8059" last="8071">
            <title>A bifunctional old yellow enzyme from Penicillium roqueforti is involved in ergot alkaloid biosynthesis.</title>
            <authorList>
                <person name="Gerhards N."/>
                <person name="Li S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28902217"/>
            <dbReference type="DOI" id="10.1039/c7ob02095c"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBUNIT</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>COFACTOR</scope>
        <scope>ACTIVE SITE</scope>
        <scope>MUTAGENESIS OF TYR-174</scope>
        <scope>PATHWAY</scope>
    </reference>
    <comment type="function">
        <text evidence="3 4">Chanoclavine-I aldehyde reductase; part of the gene cluster that mediates the biosynthesis of isofumigaclavines, fungal ergot alkaloids (PubMed:28902217). The tryptophan dimethylallyltransferase ifgA catalyzes the first step of ergot alkaloid biosynthesis by condensing dimethylallyl diphosphate (DMAP) and tryptophan to form 4-dimethylallyl-L-tryptophan (PubMed:28620689). The second step is catalyzed by the methyltransferase ifgB that methylates 4-dimethylallyl-L-tryptophan in the presence of S-adenosyl-L-methionine, resulting in the formation of N-methyl-dimethylallyl-L-tryptophan (PubMed:28620689). The catalase ifgD and the FAD-dependent oxidoreductase ifgC then transform N-methyl-dimethylallyl-L-tryptophan to chanoclavine-I which is further oxidized by ifgE in the presence of NAD(+), resulting in the formation of chanoclavine-I aldehyde (PubMed:28902217). The chanoclavine-I aldehyde reductases ifgG and/or fgaOx3 reduce chanoclavine-I aldehyde to dihydrochanoclavine-I aldehyde that spontaneously dehydrates to form 6,8-dimethyl-6,7-didehydroergoline (PubMed:28620689, PubMed:28902217). The festuclavine dehydrogenases ifgF1 and/or ifgF2 then catalyze the reduction of 6,8-dimethyl-6,7-didehydroergoline to form festuclavine (PubMed:28620689). Hydrolysis of festuclavine by a yet undetermined cytochrome P450 monooxygenase (called ifgH) then leads to the formation of isofumigaclavine B which is in turn acetylated by ifgI to isofumigaclavine A (PubMed:28620689). Penicillium roqueforti has interestingly at least two sets of genes for the consumption of chanoclavine-I aldehyde on three different loci, the OYEs ifgG/fgaOx3 and the festuclavine synthase homologs ifgF1/ifgF2 (PubMed:28620689, PubMed:28902217). The reason for the duplication of these genes is unclear, probably to ensure the conversion of chanoclavine-I aldehyde by differential gene expression under various environmental conditions (PubMed:28902217).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>dihydrochanoclavine-I aldehyde + NADP(+) = chanoclavine-I aldehyde + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:35947"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65032"/>
            <dbReference type="ChEBI" id="CHEBI:71487"/>
            <dbReference type="EC" id="1.3.1.100"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Alkaloid biosynthesis; ergot alkaloid biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Monomer (PubMed:28902217).</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the NADH:flavin oxidoreductase/NADH oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.100" evidence="4"/>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q9S9"/>
    <dbReference type="SMR" id="W6Q9S9"/>
    <dbReference type="STRING" id="1365484.W6Q9S9"/>
    <dbReference type="OMA" id="MMATYYK"/>
    <dbReference type="OrthoDB" id="276546at2759"/>
    <dbReference type="UniPathway" id="UPA00327"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003959">
        <property type="term" value="F:NADPH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035835">
        <property type="term" value="P:indole alkaloid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd02933">
        <property type="entry name" value="OYE_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000138">
        <property type="entry name" value="NADPH dehydrogenase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045247">
        <property type="entry name" value="Oye-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893">
        <property type="entry name" value="NADH OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893:SF91">
        <property type="entry name" value="NADPH DEHYDROGENASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0017">Alkaloid metabolism</keyword>
    <keyword id="KW-0285">Flavoprotein</keyword>
    <keyword id="KW-0288">FMN</keyword>
    <keyword id="KW-0521">NADP</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000444542" description="Chanoclavine-I aldehyde reductase fgaOx3">
        <location>
            <begin position="1"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="174"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="23"/>
            <end position="25"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="292"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="316"/>
            <end position="317"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="317"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="344"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="mutagenesis site" description="Impairs the catalytic activity and formation of festuclavine in vitro." evidence="4">
        <original>Y</original>
        <variation>F</variation>
        <location>
            <position position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="Q02899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="Q4WZ70"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="28620689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="28902217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="5">
        <source>
            <dbReference type="PubMed" id="28902217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="6"/>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM33403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="369" mass="40053" checksum="745681DBD7B0C751" modified="2014-04-16" version="1">MTKLFTPLHVGRMELANRIAMAPMTRYRASDNHVPLPIMKDYYAQRASVPGTLLITEATTISARAGGYANAPGIYNDAQIAAWKEVTDAVHAKGSYIYVQLWAVGRPANPQLLQAEGGYDLVSSSATAVSADAPTPRALSETEIYAWIADYAQAARNAVAAGFDGVEIHAANGYLIDQFTQDICNTRTDAWGGSVQGRARFALEVSRAVVEAVGADRTGIRFSPWSTFQGMRMKDPKPQFEYLAVQTAKLGLAYVHLVESRIAGGADVDATDRLDFFLRAYGKASPVIFAGGYDAESAVRAVDVEYADYDAIVGIGRPFISNPDLPFRVQNGIPFVPYDRATFYVPKDPKGYTDYAFSAEFQKAIEAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q9T0</accession>
    <name>W6Q9T0_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g000346</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q9T0"/>
    <dbReference type="STRING" id="1365484.W6Q9T0"/>
    <dbReference type="OMA" id="NQIHRYD"/>
    <dbReference type="OrthoDB" id="540004at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052356">
        <property type="entry name" value="Thiol_S-MT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45036:SF1">
        <property type="entry name" value="METHYLTRANSFERASE LIKE 7A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45036">
        <property type="entry name" value="METHYLTRANSFERASE LIKE 7B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="1">
        <location>
            <begin position="74"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM26537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="249" mass="27715" checksum="01C990611757578E" modified="2014-04-16" version="1">MGPDLVLDLPQVFVHWESLTQAVRRDGLAALGRPQQIRDAASAKLFSITSGNFIAYEDTTVVPSLVQAASGVILELGPGPGNQIHRYDTALVKHVHGIEPNPHFKDAIDAKLDKYNLRDRYKVIVCGIEDSDVLREEGITEGSLDAVLCIQVLCAVKDPKNVMKEVWKLLKPGGKFIFWEHGWSRNRLTTVAQACWNPAWSIFVGCDLTRNVLADILNSGEWENPREVQEPEEPFSLLPRIQGVLVKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>W6QA04</accession>
    <name>W6QA04_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Dynamin, GTPase domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PROQFM164_S02g001159</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QA04"/>
    <dbReference type="STRING" id="1365484.W6QA04"/>
    <dbReference type="OMA" id="RCERMIL"/>
    <dbReference type="OrthoDB" id="9984778at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008053">
        <property type="term" value="P:mitochondrial fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051646">
        <property type="term" value="P:mitochondrion localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000638">
        <property type="entry name" value="Transmembrane GTPase Fzo1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027094">
        <property type="entry name" value="Mitofusin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10465:SF0">
        <property type="entry name" value="SARCALUMENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10465">
        <property type="entry name" value="TRANSMEMBRANE GTPASE FZO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="13">
        <location>
            <begin position="274"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="498"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="503"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="521"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDM31009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="922" mass="101499" checksum="3426118ACB088676" modified="2014-04-16" version="1">MSQEYHPGEGPSSGAGSSRFSGEEEFPQKNPFFRPPPTYMTVGNGSTSDSATALMTSLNQDSGYGGSIADTEEDANSAWRAGLMEDRPTPVHTPTRPGEWNPAAEHEKQVVASHVSQLLYNSNRTKLARAISRTIDTLKELQEMNRQWPAHYPSVGSTPSSPMVRPSLHQTQSEFGGNDNILSTPPLRRAATLAVSDELGESSASVQRRVPTEPRLMTPQIAQEFSILKLDLKLGALSQAELVHSLEKASVAALLDGKISQSMKHLLSLRDRIEDTSSKVLITGDLNAGKSTFCNALLRRKVLPEDQQPCTSIFCEVLDARENCSVEEVHAVHKDTPYNRNDESTFDVYALTELENIVIENTKYMQCKVYVRDVRSIDESLLNNGVVDIALIDAPGLNSDSLKTTAVFARQEEIDVVVFVVSAANHFTLSAKEFILNAAHEKAYIFMVVNGFDQIRDKKRCERMILDQIGKLSPRTYKEAAELVHFVSSNAIPVAPSAFSQSGSGGGDGGGSDPHDDDADKDSKDKGKGKEREKLQDFENLEGALRRFVLEKRSRSKLAPAKTYLLNLLADIGSLATVNRDVAQSELKRVTDELAELVPAFENGKKKKGEIAEGVNKAIDDSCDDVYNHTRSTLTNTITRVSDADLGVEYPGLFSAFQYAEELKLAMLDEIASSVNNCEDYAREKTVQGVGFIQNIGLLHIGEDKFTPLNFRADAMFRRGRRHTFGRQVDTEVELWDFFDFAGLWERQEKMAGTGVAMTAVTVLGGRALGGFGWVDSALSAVKVIGPNNMRRLFFPSLLAAAVLTTAYVLSSIPTTLPPRLSRKIAATLAEMDYVHSNANRISTEVRRMLRLPANNLQTCLSQDIEDLGKRKQEVTKIKQESDVATKYFSNLFRDSSENRRSIENLDLDAPLPGGMAAAMQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W6QA83</accession>
    <name>W6QA83_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g000506</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QA83"/>
    <dbReference type="STRING" id="1365484.W6QA83"/>
    <dbReference type="OrthoDB" id="73875at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029476">
        <property type="entry name" value="DNase_NucA_NucB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14040">
        <property type="entry name" value="DNase_NucA_NucB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Deoxyribonuclease NucA/NucB" evidence="1">
        <location>
            <begin position="18"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM26697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="326" mass="36717" checksum="76AE933CF3BF7C2B" modified="2014-04-16" version="1">MPGLCDNIDGVTARRNSVYPRKTVGGQSVTKCSAPTAELNKAVRRRGLSLQCDEFPWGSSEQGGEWLPASQRRTECVTSFQNAWHGNCVQLVGQLSSNWKQLDPESRKDSKKIDYWASWQKRTDWTHAGKYGIGQNIPYEQKLIEYGEEMPPPDGGDQGDNKKLSWAFKRDYETSWLNPQTPLTSADWWNANQPTWYKPKYNGPLTMDSVLCAVNHFNQGNVYKLPGVKVKSDGTPIGVQKEYNAYCKRTNQGGMAPPAWGVDFTMGRCLIRFQNSASSSSGTSKRDAQKWGEWEVESIEYVEDVDDAEMAQLLKPADLDGSEHER</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W6QAI4</accession>
    <name>W6QAI4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S02g003197</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM33046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QAI4"/>
    <dbReference type="OMA" id="RIPFECE"/>
    <dbReference type="OrthoDB" id="4368451at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM33046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="160" mass="18083" checksum="274B7B082462AF46" modified="2014-04-16" version="1">MPCQFPFECEPFYMRPLLITTSIISGFFKTLIYFLIPVTVAIAIIFILAFLLFAILAALFGWDMNSEESKAKREKEKEKEKKEREQRESDAEQITAPPVAGNIPGDTIDLEKRLEIEIELLAEMVLARRRRLDALKEMHLGDNSADVVQSNTYVPGSGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>W6QAJ7</accession>
    <name>W6QAJ7_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Methionine aminopeptidase</fullName>
            <ecNumber evidence="11">3.4.11.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PROQFM164_S03g000174</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 11">Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 11">
            <text>Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.</text>
            <dbReference type="EC" id="3.4.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="11">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="11">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="11">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="9">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with zinc, cobalt, manganese or divalent iron ions. Has high activity with zinc; zinc cofactor is transferred into the active site region by the ZNG1 zinc chaperone.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Associates with the 60S ribosomal subunit of the 80S translational complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9 10">Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.18" evidence="11"/>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QAJ7"/>
    <dbReference type="STRING" id="1365484.W6QAJ7"/>
    <dbReference type="OMA" id="FYGDHAY"/>
    <dbReference type="OrthoDB" id="3209743at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004239">
        <property type="term" value="F:initiator methionyl aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01086">
        <property type="entry name" value="MetAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.230.10:FF:000010">
        <property type="entry name" value="Methionine aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01974">
        <property type="entry name" value="MetAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002467">
        <property type="entry name" value="Pept_M24A_MAP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031615">
        <property type="entry name" value="Zfn-C6H2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00500">
        <property type="entry name" value="met_pdase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43330">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43330:SF7">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15801">
        <property type="entry name" value="zf-C6H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00680">
        <property type="entry name" value="MAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52013">
        <property type="entry name" value="ZF_C6H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9 11" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9 11" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C6H2-type" evidence="12">
        <location>
            <begin position="6"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>a protein</name>
            <dbReference type="ChEBI" id="CHEBI:16541"/>
        </ligand>
        <ligandPart>
            <name>N-terminal L-methionine residue</name>
            <dbReference type="ChEBI" id="CHEBI:64731"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>4</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>4</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="286"/>
        </location>
        <ligand>
            <name>a protein</name>
            <dbReference type="ChEBI" id="CHEBI:16541"/>
        </ligand>
        <ligandPart>
            <name>N-terminal L-methionine residue</name>
            <dbReference type="ChEBI" id="CHEBI:64731"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="312"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>4</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="343"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>4</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="343"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>3</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDM33450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="374" mass="41581" checksum="6B4D0B71FDD4D663" modified="2014-04-16" version="1">MAEVATRKCRGVDCPNDAGTLQCPTCLKSGTDSFFCSQDCFKRSWSEHKSIHKKTTGTFNPYPSFPYAGSLRPVYPLSPKRTVPKTIPHPDYARDGIPRSEQKLIGRHNITILNKEEQEGMRKVCRLAREVLDAAARELKPGVTTDYLDEVVHKACIERDSYPSPLNYMNFPKSVCTSVNETICHGIPDQRPLQDGDIVNIDVTLYHKGFHGDINETYYVGDKALANPDAVRVVETSRECTNKSIELVKPGMLFREPGNLIEKHAKSRNCSVVKSYCGHGINQLFHCAPNIPHYAKNKAVGTAKPGMCFTIEPMINLGTYRDRTWPDDWTSTTQDGLLSAQFEHTLLVTEDGVEVLTARLPDSPGGPVPMPSTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W6QAU1</accession>
    <name>W6QAU1_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Actin-like protein arp6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">arp6</name>
        <name evidence="3" type="ORF">PROQFM164_S01g000641</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QAU1"/>
    <dbReference type="STRING" id="1365484.W6QAU1"/>
    <dbReference type="OMA" id="FFEEYEC"/>
    <dbReference type="OrthoDB" id="6220758at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd10210">
        <property type="entry name" value="ASKHA_NBD_Arp6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000036">
        <property type="entry name" value="Actin-like protein ARP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000058">
        <property type="entry name" value="Putative actin-related protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.36.70">
        <property type="entry name" value="Actin, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM26832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="470" mass="51932" checksum="142515D8C4113BA1" modified="2014-04-16" version="1">MVAAKARAPPRTPATPIQPVETSRYLPDKTFVIDNGAYMIKAGYASHASASDESVSACSSIPNALVRTRDNKIVIGAQLATVNDWNEAMFRRPVEKGYVVNWEAEREIWDQSFFDGKVTARNRNHHIADPEDTTLVLTEAPNALPILQRHADEMVMEEWGFGGYARCLGPTLNAWNEIHSLFGDPLSNTSDASILPADCLLVVDSGYSHTTVTPVYKGQALQRGIRRLDLGGKHLTNYLKEIVSMRQYNMVDESYIMNEVKEAVCYVSNDFSGDLEQAWKSRRKRQSGPEEGIVLDYVLPDPNANKKGFIRPHDPLLHAKKKKGAVSGLSAEVLSEDVLVLGNERFTVPELLFTPGDIGMKSAGIPDMILQSLSVLPTGLHSAFLANVLVVGGNALIPGFMERLETELRQIASAECVVRVRRAKDPVHSTWLGGTRLAANREELSKVSITRQEYQEYGSGWAVRRFAGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W6QC07</accession>
    <name>W6QC07_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="9">AAA+ ATPase domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PROQFM164_S01g000996</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QC07"/>
    <dbReference type="STRING" id="1365484.W6QC07"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042626">
        <property type="term" value="F:ATPase-coupled transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF345">
        <property type="entry name" value="ABC MULTIDRUG TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="247"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="287"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="1"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM27187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="333" mass="36935" checksum="FD9662D4C49E8152" modified="2014-04-16" version="1">MDSRLIVGPIGSGKFTLCKAILGEIPFHQGEITLRTRALYENIIGLSSVNEDRYAEVVEATALAFDFKTLPQGDETNVGSDGISLSGGQRQRISLARALYLQANLLILDDVFSGLDADTEEQDFRKVFSPEELLKRRQATVLLYTHSVRHLQAEDYVITLGNGSVSEQGTFDALIAGDGYVHRLGLNGLSESETTSEELIIENNVQEYLSPVDKIKRAKLAVAPNLDASRQVGDGTVYKQYMKSMGWLLAGSAVFFAFLRGFFLHFSTIWLMYWVEDAQSQRPKHHSAYWAGIFALFQIGVLISLFLLGAPIWIVSIKRAGANLHMDILNTLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W6QCF1</accession>
    <name>W6QCF1_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acyl-CoA N-acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S02g002005</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QCF1"/>
    <dbReference type="STRING" id="1365484.W6QCF1"/>
    <dbReference type="OMA" id="CEDEDYA"/>
    <dbReference type="OrthoDB" id="2019666at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="26"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM31854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="192" mass="21179" checksum="D0288C73B5ADA8E6" modified="2014-04-16" version="1">MCEDYANNTYPQAPTKVVGVSTYSRVIIEGKLVGHAFGCRWTCKGGTVCWITQLVVDRHHRGKGFATSLLRILRTDHDTIYGVMSSHPAACLAAVKAFDRTIEKVDLDFIAKNANETMSTSPVPYIRDAELCGIIFDGKDTTGIVSGVNTKFFVDHKEPLKALAVVEKKWDWPLGKLPEGYEYLLILPASAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W6QCG1</accession>
    <name>W6QCG1_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Beta-ketoacyl synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PROQFM164_S01g001111</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-A beta-lactamase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QCG1"/>
    <dbReference type="STRING" id="1365484.W6QCG1"/>
    <dbReference type="OMA" id="CGGHGIW"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050789">
        <property type="entry name" value="Diverse_Enzym_Activities"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43283:SF17">
        <property type="entry name" value="(LOVD), PUTATIVE (AFU_ORTHOLOGUE AFUA_5G00920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43283">
        <property type="entry name" value="BETA-LACTAMASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01294">
        <property type="entry name" value="PKS_PP_betabranch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="175"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDM27302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="542" mass="58901" checksum="78A90DCF6AD80AE9" modified="2014-04-16" version="1">MTLEQFNTAIRPKVNGAINLHNATINVNANLDFFMTSSTVTYVGHISQSNYAASNAVLDNLERQRISNGLPAATVSLGPIKGVGTLNRNPEYAENLLRSGLIEAEESEFIRHFNRFTHPQLKSKHFDSLTQGHILTGDRRSALLVTTLESRKAAGSSGGVIVDASGDDLLIPEISDDRDKAVIVLAEAVSQRLAKLMFISIEDIDISRPFSHFGLDSMSGSELIHWLSQNFGVGMSFLQLLAPSCSPKSLAGTIFDALEMKAAAAEISALVIVGGTSHESPNESLVSNGVNGSTGMNGSSGIDSGSAGSQMEKFSRSVRRAIADSKPVMHSYVCSVVNKKGEQLYTLSKGTLSQDSSTKVDFDAVYGMASLTKLMTTVAIMICVDRGQISLDDDIAPILPDLCAPPVLYGVGSEGRCLIKPRTKTITLRLLMSHQSGCGYHSNPPLARWARQNGKTNSVFDNDFEIMKTYPLLFEPGQGWMYGSGTDWAGEAIARMNNTTLEEFMRSNVWEPRSVVNTARLDKVPRHGARGRWIHTLQSQRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W6QD35</accession>
    <name>W6QD35_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Genomic scaffold, ProqFM164S03</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S03g001099</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QD35"/>
    <dbReference type="STRING" id="1365484.W6QD35"/>
    <dbReference type="OMA" id="ENAGWHG"/>
    <dbReference type="OrthoDB" id="3559580at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046497">
        <property type="entry name" value="DUF6590"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35391">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35391:SF5">
        <property type="entry name" value="DUF6590 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20233">
        <property type="entry name" value="DUF6590"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6590" evidence="2">
        <location>
            <begin position="261"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="161"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM34375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="424" mass="47576" checksum="6A4EB956CBE3CC22" modified="2014-04-16" version="1">MASNWVLHHESNRWVRPIYNHSGEFLYEWDCMGGELTPAIAGQDSSVALCQRSTSESAFPTLKDAYGHQLPFPPGLDPHASRLNRVHQQDPLDYGQAYTNDHFNPRTPPTGYQQLINHQVDNGIYPGAGTVTDDKASSPPEWSPNMQYKVARDTTGRRTGSASISDRSDVTSSSRSDVSIPEIHIEDLQGLSLGDHPASHMVLPYEASSHSHCNDSIPGDVQRKRHDRKVQKSSEPAYVIPGSSSEHDTLDPRYKRQSDPRRFFRVGRVFSMLWHENAGWHGTIVSEKLPSSSSPFTRGKYQEPIYSSIRRMVVVKEQKGCCWCVPITTYSGQGVAKAGVDRSKHAVIHMRGDRPRTVKSEPRMAKEPLEVDPARPDQKLDCMSRVNFGKVYTVEHNVKVLPVGKITEASRARFLEYAQGEFIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W6QDB9</accession>
    <name>W6QDB9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S03</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S03g001194</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QDB9"/>
    <dbReference type="OMA" id="EITEREW"/>
    <dbReference type="OrthoDB" id="4526194at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM34470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="520" mass="57282" checksum="CBDCBF33E5B3432D" modified="2014-04-16" version="1">MAIRALAEGSAATLDDGTIVLPLSDLCPHPEPIDSISLLLYQETMTSLLRWGLQVFPQQPTYREPNLWRSMAILDGPRGYNQRLVDTEDTWLDMMTQRREPLPEEVVCDPDMLPMLPSMTRGPVRPLDDDLTYIENLLRRDRTVHTVLATRCPFGWKRLWIECVCLHVSADETAALLAVLPDQDTPTIVLNAQIREMAGPAADAEDILGLAGLESWEASQRSFVLRKNLMLRPPQHPGRLSHGQSISLQKEESKGSVGVFLAPTSNNDDGEKYALTAYHVLPYLEKKQTQVITPGGLDILSELFKTVSEADSQSRARLLSAWVEPCGTVVHGDIGVNSQGWRSDLALVRLADGWECHNGRWFNSRGTDVMTELLSVTKEAPRPPATFNLHHIVGPADPDAGAIVYKDGARTGCSAGRVGPFESKMFRARTADSSDMSDPTVMVARLLTLYPLSEATEPVCGTGDSGAGVFMPCYAMGGWQWAGQLVSLGLVRNQTIGLFVPSSAVLLSLREITEREWRLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W6QDE8</accession>
    <name>W6QDE8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type DNA-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PROQFM164_S03g001224</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QDE8"/>
    <dbReference type="STRING" id="1365484.W6QDE8"/>
    <dbReference type="OMA" id="THARECV"/>
    <dbReference type="OrthoDB" id="4356994at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053187">
        <property type="entry name" value="Notoamide_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47256:SF1">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47256">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="49"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="145"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="161"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM34500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="178" mass="19635" checksum="983BFFA6365737A7" modified="2014-04-16" version="1">MNEQTLRGYRPLAPRTRLLGGSGGDGGEGGSPSGGGAPEEKRMRRASTACTECQKRRTRCTGPPNCTECSTHARECVFDEAADRRRKASAKRIQDQLDHFRSFVDDLIGLIRDSDGPSVQLIVNTIRSGATPGEIRDILTRLLDDDNQSDSRNSGMRDSDVNLNFTNNHMGNYFHPPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W6QEV5</accession>
    <name>W6QEV5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g001928</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1365484.W6QEV5"/>
    <dbReference type="OMA" id="YATPMRT"/>
    <dbReference type="OrthoDB" id="2142961at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016071">
        <property type="term" value="P:mRNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028322">
        <property type="entry name" value="PNRC-like_rgn"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15365">
        <property type="entry name" value="PNRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="121"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="344"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="371"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="401"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="426"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM28117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="463" mass="50491" checksum="F3B271375675EA57" modified="2014-04-16" version="1">MSTQSPHPPTPKGSRNNRRPQKKNTTPHAQKPALLSTPPSSPPHNMSPGVIQVDSLTNFNSSKKKPMRSGKKPRDSKASPATSGYHSNGYNSGPRYTPTQPAVTSPQPKPSAAYAGPTFHASPAPSALPIPSFFSKSAPDPNLVPPIETDSDDAEVDPEPDVTPSKPRNRSNQFKAEEPKPSPLDFLFKAAVQARDQKSTSSPEVNKVLQSPQTEPRALRPNPDGMFAFEMGNSDYTRNLHIGPSFAPSYQDRMNALRPSSTSQSSDMTEEERRIKTEELKHLLLNPPPQKPPSSAYASHDHARSFGPRPSNVPPYATPMRTTSGPQLTLSHSSFSNQQLQQQHIPQNTGRPQYQYPTHSHSPLRREVDLVPPPSMPPYRGPVSNRASNGGSPAPYGNPYMATSQDQRSGYASPQPSHAASPFQMPVSSPSPSRVVDTRQIENDIRRVLKLDTSGPPVTRSFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W6QF27</accession>
    <name>W6QF27_PENRF</name>
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        <submittedName>
            <fullName evidence="5">Nucleotide-binding, alpha-beta plait</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PROQFM164_S04g000239</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1365484.W6QF27"/>
    <dbReference type="OMA" id="YKPVWID"/>
    <dbReference type="OrthoDB" id="407442at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="entry name" value="RRM_PPIE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034168">
        <property type="entry name" value="PPIE_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48037">
        <property type="entry name" value="ATPASE E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48037:SF1">
        <property type="entry name" value="RRM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
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        <location>
            <begin position="9"/>
            <end position="90"/>
        </location>
    </feature>
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        <location>
            <begin position="115"/>
            <end position="152"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDM35358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="152" mass="16377" checksum="DD8512A15A6CC598" modified="2014-04-16" version="1">MSETTRLKSTVYVGGLDQGVTTLTLAEAFVPFGEVVDISLPKPDQPNSAEVHRGFGYVEFDLPQDAKEAIDNMDGSEIYGRTIKVAAAKPQKDANEGLGSKTAIWEQEGYLAKHAVSEEDREAAEEAQAASSRPQDPMQGLEQLDVAGPKPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W6QF44</accession>
    <name>W6QF44_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S04</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">PROQFM164_S04g000269</name>
    </gene>
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        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="4526473at2759"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM35388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="75" mass="8999" checksum="3CD65E768A2A3689" modified="2014-04-16" version="1">MPTLRKLGLSEKYHQALQRYSEVAPYRSPNPFQTEFAFAKWLVEVREDRPELYAFWSKLFPVCYDRTVYESASIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W6QFB9</accession>
    <name>W6QFB9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Probable transposable element</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S02g002975</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QFB9"/>
    <dbReference type="STRING" id="1365484.W6QFB9"/>
    <dbReference type="OMA" id="TIANWIM"/>
    <dbReference type="OrthoDB" id="5379619at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038717">
        <property type="entry name" value="Tc1-like_DDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047655">
        <property type="entry name" value="Transpos_IS630-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF033545">
        <property type="entry name" value="transpos_IS630"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46564">
        <property type="entry name" value="TRANSPOSASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46564:SF1">
        <property type="entry name" value="TRANSPOSASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13358">
        <property type="entry name" value="DDE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tc1-like transposase DDE" evidence="1">
        <location>
            <begin position="145"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM32824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="327" mass="37820" checksum="3BC91EDF0DE92CB8" modified="2014-04-16" version="1">MAPRLSPSKRQFISDMIQGQSLTRYRMADAAECSEQTIKNIRRNLRLFGNVHAPPNRVGRRRSITPLMLEALFDHLLEKPGLYLDEMAIFLWDELQMLATTSSIRRALVSNGWSRKTARQKAKEQNAELREIYLHNLSEFESYHLVYVDESGCDKRISFRRTGWSPLGVAPRQVSQFHRDERYQILPAYAQDGLVLSRVFRGSTDAIVFEDFIDELLRHCGRWPEPKSVLVMDNASFHYSERISQMCADAGVKVVYLPPYSPDLNPIEEFFSELKGFIKRNWSYFADDPDRDFSTFLERCINQVGAKKDSARGHFRHAGLSVEDLDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>W6QFQ3</accession>
    <name>W6QFQ3_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">rRNA 2'-O-methyltransferase fibrillarin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Histone-glutamine methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">nop-1</name>
        <name evidence="14" type="ORF">PROQFM164_S03g001503</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-glutaminyl-[histone H2A] + S-adenosyl-L-methionine = N(5)-methyl-L-glutaminyl-[histone H2A] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50904"/>
            <dbReference type="Rhea" id="RHEA-COMP:12837"/>
            <dbReference type="Rhea" id="RHEA-COMP:12839"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30011"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61891"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the methyltransferase superfamily. Fibrillarin family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QFQ3"/>
    <dbReference type="STRING" id="1365484.W6QFQ3"/>
    <dbReference type="OMA" id="WNPNKSK"/>
    <dbReference type="OrthoDB" id="1859733at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031428">
        <property type="term" value="C:box C/D methylation guide snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990259">
        <property type="term" value="F:histone H2AQ104 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008649">
        <property type="term" value="F:rRNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000494">
        <property type="term" value="P:box C/D sno(s)RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000452">
        <property type="term" value="P:snoRNA guided rRNA 2'-O-methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000056">
        <property type="entry name" value="Fibrillarin like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000001">
        <property type="entry name" value="Fibrillarin like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00351">
        <property type="entry name" value="RNA_methyltransf_FlpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000692">
        <property type="entry name" value="Fibrillarin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003276">
        <property type="entry name" value="PRK04266.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10335:SF17">
        <property type="entry name" value="FIBRILLARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10335">
        <property type="entry name" value="RRNA 2-O-METHYLTRANSFERASE FIBRILLARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01269">
        <property type="entry name" value="Fibrillarin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00052">
        <property type="entry name" value="FIBRILLARIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01206">
        <property type="entry name" value="Fibrillarin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 14" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 14" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="8"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDM34776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="329" mass="34338" checksum="DF9505E2C2D3E83D" modified="2014-04-16" version="1">MSSFAPRGRGGFGGDRGGGRGGRGGFGDRGGRGGGRGGFGDRGGRGGGRGGFGDRGGRGGGRGAPRGGRGAPRGGRGAPRGGGGARGGAKVVIEPHRHAGIFVARGGKEDMLVTKNLTPGTAVYGEKRISVEGPATEDGTVTKNEYRVWNPFRSKLAAGVLGGLDDIYMKPGSKVLYIGAASGTSVSHVADIVGPTGNVYAVEFSHRSGRDLIGMATHRTNVIPIVEDARHPLRYRMLVPMVDVIFADVAQPDQARIVGLNAHMFLKDGGGVIVSVKANCIDSTAKPEVVFAKEVQKMREEKIKPKEQLTLEPFERDHCIVAGIYKRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W6QG16</accession>
    <name>W6QG16_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cell division protein Cdc14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g002408</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QG16"/>
    <dbReference type="STRING" id="1365484.W6QG16"/>
    <dbReference type="OMA" id="YMNILLD"/>
    <dbReference type="OrthoDB" id="5357220at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012535">
        <property type="entry name" value="Cell_div_Cdc14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34065">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34065:SF1">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08045">
        <property type="entry name" value="CDC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="229"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM28597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="281" mass="31399" checksum="2BC177663776363B" modified="2014-04-16" version="1">MEALLAHSFDYLSSYEPSKIRKGLRQVEGLLAQICLSKPKPVLDRRSRSPDIQPVPKTLPELRDDPAFREFSKLQESFQWNIAMRLVSCLEHLLGRGSNGTNDMLIVCTLDLIQGALLLHRGSRSLFAREIYMNLLLDLLDPINCPAVQSATLLTLVTALLDCPSNTRTFEGLDGLLTVTSLFKQRATSREVKLKLVEFLYFYLMPEALTSAPMSPQGLQRSPSKRTSARSPRSAAAAASKVSRDIRTTDEKQNLLGRYLNNVEDLVEDLKETAPFGATVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W6QG96</accession>
    <name>W6QG96_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Late secretory pathway protein AVL9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S01g002478</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AVL9 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QG96"/>
    <dbReference type="OMA" id="TWDDAHP"/>
    <dbReference type="OrthoDB" id="192887at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018307">
        <property type="entry name" value="ABL9/DENND6_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051731">
        <property type="entry name" value="DENND11/AVL9_GEFs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037516">
        <property type="entry name" value="Tripartite_DENN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31017:SF1">
        <property type="entry name" value="LATE SECRETORY PATHWAY PROTEIN AVL9 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31017">
        <property type="entry name" value="LATE SECRETORY PATHWAY PROTEIN AVL9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09794">
        <property type="entry name" value="Avl9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50211">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDENN" evidence="3">
        <location>
            <begin position="9"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="512"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="594"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="676"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="734"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="512"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="601"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="703"/>
            <end position="716"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM28667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="788" mass="87906" checksum="71A0D70299DE0680" modified="2014-04-16" version="1">MAVHHKQDTIVLVIDFHHARGPEIEHCIAEEGTDPATENDWSLLPFMALSDGAHLSTEEFSYFTLCRKATSTAPETSLFGIACSRQIDSSLLINPSPDVTRSTVQKAVVVVTDTPQRVGHLREKLSVVTSAWFAQRDFSDIDILKKFREGLVISLLNDGPKDQNLGLSLREMIHEFKFQTLVLFKALLLQPKMLFFGTRCERLCMIQFSLISLIPGLINSLQDCADPAFDTYSQTVEKPTSLKTSDRSSLLAYMGLPLQIFGKGSMFGPYTPLQLLDLLADDGTKSYVVGSTNSLLLQQKDRYSDILINLDEDSIVINSPSLRNALVLSAADRRWIDLLTQIVNDTWDEEHPSQPNTLGFMGSEEFIRLQFEEYLLALLSSMKYHEELYPSDVGESAARSRTQLQNLNIEGDPATDFNTEFLTQWKTTYNYALFSRLTSDALLFSITEPRHPSAGGLTMEDVQRRLAQQVADLHLDERVREGREALNRHFSTGQKKVSAAFTSFWSDLETMREAQRKRTEERAASQSQRTSIDKETPISPIPTSPNPSDASWFANRPRASVDLTQAQASVSVASQKAGSYLSSWGTWASEKRREWQEKRVTSPSPSTSPNAELTSASTPILSIVTQTAEMDRGRRRSILRNSEGNESPKEGLSRSTSRRKRWSNIILRRDSGEFQRYEDVPTSDSIETPFPKSPLSQGFPAYDPHKQTENLKQDGKDTVDADGFAPVALTSNEGLGLSLKTEETVPQIQEPTPPSGEEVDTPLEDLATGLPVKEEAHPVQSKDSSGTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>W6QGQ4</accession>
    <name>W6QGQ4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Zn(2)-C6 fungal-type DNA-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PROQFM164_S04g000032</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QGQ4"/>
    <dbReference type="STRING" id="1365484.W6QGQ4"/>
    <dbReference type="OMA" id="WPNVWDA"/>
    <dbReference type="OrthoDB" id="435881at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF50">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="23"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="107"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="177"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="190"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM35151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="727" mass="81979" checksum="858C7A2FFFBFF051" modified="2014-04-16" version="1">MADPVGQVGTTHSRSSAPRVRLTCEACRQRKVKCDKLSPCTSCQRLGLVCIPVERARLPRGRARKPERIVGSDKELSERVARLEKLLKIVANERGDESHISSIVHVPSHSSTQQESVAEASTAGPDTHQDHDYLPGAAQPHLPRPSTAYVGGPFWEDIMQQTQELRSVLEDRLENENHDIKDSASGFGVSVLSSESPDSPSNSPQANSRLNLQPQIRHRLCDIFFRNVDPLFKILHRPSLQAFIRDGKPYLDYEQDHQAPATLASAIYLCAVCTLDEVESQSMFNTSQKIIVAEFQKETESALAKADFVTTNDLTVLQAYIISLLAARSQDQSRRVWTMLSMALRVGQALSLHMPQPPFTVRPFEHEMRKRAWLGIGLLDVAASLDRASEPMMQSAWLDYNPPLNINDEDLWFDMTWPISEHTEGTFTDMTHTLVSAAAASVTRTLAFSDVTEPAVTIMSLRQQVVHDFQQKTSVLLGGCRPDLSDFQWYAQKTACLMGSWLQLACLRPLQRSYNFIPPKIQENALLKIAADNLQCSQEVYNHPGSRSWRWYQSMWVPWHALAVALAELCVCKSPTVMSKYWTVVEDVYHRSRLVIADSQQGMLWKPLERLMSQAKTQRNQLLGIDASRQEYSFDGISPELFSEQSERQQDLTNFSLDLREAVDGPRDSHVAEVPTSFAPVPWPNVWDAMDFSDPTLQSSSDDTAWLSYENFIDNVYDSVDSIFLPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W6QGU5</accession>
    <name>W6QGU5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ribosomal protein S17</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PROQFM164_S03g000133</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS17 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QGU5"/>
    <dbReference type="STRING" id="1365484.W6QGU5"/>
    <dbReference type="OMA" id="DYEKCPF"/>
    <dbReference type="OrthoDB" id="10254436at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00364">
        <property type="entry name" value="Ribosomal_uS17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.1000:FF:000001">
        <property type="entry name" value="40S ribosomal protein S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000266">
        <property type="entry name" value="Ribosomal_uS17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028333">
        <property type="entry name" value="Ribosomal_uS17_arc/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019979">
        <property type="entry name" value="Ribosomal_uS17_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032440">
        <property type="entry name" value="Ribosomal_uS17_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03630">
        <property type="entry name" value="uS17_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10744">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S11 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10744:SF9">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00366">
        <property type="entry name" value="Ribosomal_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16205">
        <property type="entry name" value="Ribosomal_S17_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00973">
        <property type="entry name" value="RIBOSOMALS17"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00056">
        <property type="entry name" value="RIBOSOMAL_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS17 N-terminal" evidence="5">
        <location>
            <begin position="8"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDM33409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="160" mass="18410" checksum="F0D8EF56DA2FFB35" modified="2014-04-16" version="1">MATELTVQSERAFQKQPHIFLNTKAKASSKKTAQGRRWYKDVGLGFRTPKTAIEGSYIDKKCPFTSQVSIRGRVLVGKVVSTKMHRTLVIRREYLHYVPKYNRYERRHKNLSAHVSPAFRVEEGDLVTVGQCRPLSKTVRFNVLKVHAKTSRAVKSFSKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W6QI33</accession>
    <name>W6QI33_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Fanconi-associated nuclease</fullName>
            <ecNumber evidence="8">3.1.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PROQFM164_S04g000557</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Nuclease required for the repair of DNA interstrand cross-links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>Hydrolytically removes 5'-nucleotides successively from the 3'-hydroxy termini of 3'-hydroxy-terminated oligonucleotides.</text>
            <dbReference type="EC" id="3.1.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the FAN1 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.1" evidence="8"/>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QI33"/>
    <dbReference type="STRING" id="1365484.W6QI33"/>
    <dbReference type="OMA" id="ECRVESM"/>
    <dbReference type="OrthoDB" id="76364at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008409">
        <property type="term" value="F:5'-3' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070336">
        <property type="term" value="F:flap-structured DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004528">
        <property type="term" value="F:phosphodiesterase I activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22326">
        <property type="entry name" value="FAN1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1350.10:FF:000009">
        <property type="entry name" value="Fanconi-associated nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033315">
        <property type="entry name" value="Fan1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049132">
        <property type="entry name" value="FAN1-like_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049126">
        <property type="entry name" value="FAN1-like_TPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049125">
        <property type="entry name" value="FAN1-like_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014883">
        <property type="entry name" value="VRR_NUC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15749">
        <property type="entry name" value="FANCONI-ASSOCIATED NUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15749:SF4">
        <property type="entry name" value="FANCONI-ASSOCIATED NUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21315">
        <property type="entry name" value="FAN1_HTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21170">
        <property type="entry name" value="FAN1_TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08774">
        <property type="entry name" value="VRR_NUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00990">
        <property type="entry name" value="VRR_NUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 8" id="KW-0464">Manganese</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VRR-NUC" evidence="10">
        <location>
            <begin position="638"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDM35676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="763" mass="87627" checksum="12B2E6D1D6FC51EC" modified="2014-04-16" version="1">MSLLNFWETQRPAKRRRTVETEYSSTDAEIKPPSPSPSATAGETPAADDLGIVPSSQTELETSLPAIKTDKDAIEEYEALQNDTKTGLHVRLRDGVWQKGKSSIYVDAFNLALETVLDEESHLFDEAEMEIFAQWRGLSYESQYLYVRLFLRKTSVWHRINRLNYCSDISDLLPVAEDLQRGRSLPGSELGDTFRFAEGIEAITTLEEASSLLLLQELKAFAKEAKVQGKSKKELLAALCETSQTQKGLQDANNRNSHFTQKILDYTGGCIRISPVPRTLFERVHLVFYRSTEWTEKSLTTIILAKMSKRNFPEYIVCRSNSIFSSRETLLEFESAIQTQFAIDNILEFNGPVTTASLQQIIDLANQSYPRWKELVEQEQKKEDNMYESGEGAYLRRFSPAWVLTRIIHKSLHALGRFKEHRREHELLEELLAQRLFHAARRGAWYQRKALLEEHYMWALAPADGRSEELQRKHWKRLALRTCEAGLEDPLCHLIFHYDLQKRITKLEKALRVVKREQHDFGHVMLGKPAERTIEGIRIDTGDAPRKGKATVWIDEREGGECRVENMCLSWYRDHGWKGYHSEGGIVRTLFGYLFYDILFTYVPNVFQTAFQTCPLDLHTDVFYPSRASEINHRLVEITNGDAERIVREVYAREAEAQPCAVGLDWSFDLDDLVEIVQCFRGEALATICKVMAQGYQQRGGGIPDLFLWNHETRTVMFAEVKSENDRLSDTQRLWIHILLGAGVKVELCNAVAREVRAAECEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W6QIJ3</accession>
    <name>W6QIJ3_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="4">40S ribosomal protein MRP2, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">MRP2</name>
        <name evidence="4" type="ORF">PROQFM164_S03g000748</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS14 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QIJ3"/>
    <dbReference type="STRING" id="1365484.W6QIJ3"/>
    <dbReference type="OMA" id="FGLCRNQ"/>
    <dbReference type="OrthoDB" id="413436at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.1480:FF:000001">
        <property type="entry name" value="30S ribosomal protein S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001209">
        <property type="entry name" value="Ribosomal_uS14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19836">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19836:SF19">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US14M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00253">
        <property type="entry name" value="Ribosomal_S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM34024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="120" mass="13964" checksum="C3DB05B308BE7081" modified="2014-04-16" version="1">MSKTTKMAGLFRPKKLDLSGFVNTRLIRDNNKRMAFEQTEPERQALRYMIRNTSLSGRVRAQAQLQLAQMHPYTRPTQIKNRCVASGTARSVFRDFRINRYQFRMQALAGELPGVRKASW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W6QIV3</accession>
    <name>W6QIV3_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing]</fullName>
            <ecNumber evidence="3">1.3.1.124</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">SPS19</name>
        <name evidence="6" type="ORF">PROQFM164_S04g000817</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a (2E,4E)-dienoyl-CoA + NADPH + H(+) = a 4,5-saturated-(3E)-enoyl-CoA + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:45912"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:85101"/>
            <dbReference type="ChEBI" id="CHEBI:85493"/>
            <dbReference type="EC" id="1.3.1.124"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a (2E,4Z)-dienoyl-CoA + NADPH + H(+) = a 4,5-saturated-(3E)-enoyl-CoA + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:61892"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:85099"/>
            <dbReference type="ChEBI" id="CHEBI:85493"/>
            <dbReference type="EC" id="1.3.1.124"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="1.3.1.124" evidence="3"/>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QIV3"/>
    <dbReference type="STRING" id="1365484.W6QIV3"/>
    <dbReference type="OMA" id="MQAHVCA"/>
    <dbReference type="OrthoDB" id="2136131at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008670">
        <property type="term" value="F:2,4-dienoyl-CoA reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009062">
        <property type="term" value="P:fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05369">
        <property type="entry name" value="TER_DECR_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045017">
        <property type="entry name" value="DECR2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43296">
        <property type="entry name" value="PEROXISOMAL 2,4-DIENOYL-COA REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43296:SF2">
        <property type="entry name" value="PEROXISOMAL 2,4-DIENOYL-COA REDUCTASE [(3E)-ENOYL-COA-PRODUCING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00026117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDM35936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="316" mass="33464" checksum="186A01491E510547" modified="2014-04-16" version="1">MPLPKTEYLSDSWKDGIFANKVVFCTGGAGTICSAQVRALVHLGANACIIGRNVEKTERVAKDIATARPGAKVIGIGSVDVRKFEDLQKAVERCVKELGGIDFVIAGAAGNFLASIEQLSVNAFKSVMDIDVLGSYNTLKATLPYLRESATKHRMDTKTLQPSPIGTGGRIIFVSATIHYRGMPFQTHVSVAKAGIDALSHSVAIEYGPRGMTSNIIAPGPIAQTEGLERLLPSDALEAYTKAQPLGRFGHVRDIADATVYLFSDTGSYVTGQTLVVDGANWRMSAGGASGGSLSYPDFLLSGDDVPNVTGKKSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W6QJ03</accession>
    <name>W6QJ03_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S03</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S03g000923</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QJ03"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM34199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="46" mass="4959" checksum="EA241E681C814C39" modified="2014-04-16" version="1">MQDTEETNRQAKRKAAIEYGMQRRAPALSAEILTGVANSSSPPSPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W6QJS9</accession>
    <name>W6QJS9_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Actin-related protein 2/3 complex subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">arc3</name>
        <name evidence="7" type="ORF">PROQFM164_S01g003630</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the Arp2/3 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasm</location>
            <location evidence="1 6">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ARPC3 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QJS9"/>
    <dbReference type="STRING" id="1365484.W6QJS9"/>
    <dbReference type="OMA" id="TPSKWWL"/>
    <dbReference type="OrthoDB" id="200404at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005885">
        <property type="term" value="C:Arp2/3 protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1760.10:FF:000002">
        <property type="entry name" value="Actin-related protein 2/3 complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1760.10">
        <property type="entry name" value="Actin-related protein 2/3 complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007204">
        <property type="entry name" value="ARPC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036753">
        <property type="entry name" value="ARPC3_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12391">
        <property type="entry name" value="ARP2/3 COMPLEX 21 KD SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04062">
        <property type="entry name" value="P21-Arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016315">
        <property type="entry name" value="ARP2/3_P21-Arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69060">
        <property type="entry name" value="Arp2/3 complex 21 kDa subunit ARPC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR016315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM29817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="187" mass="21078" checksum="BF253E386F43D8D4" modified="2014-04-16" version="1">MPAYHSIFLEDRDVPVIGNFPILPLRTRTRGPAYTLPPLPNTDDLDVSPESESYDCVDEILSLFRANVLFRNFEINGPADRMLIYGTLFISDCLGKVKPTMTAREAEKALTNAALDSFAIPGDVSFPLNQAFEPPRDRQDAETLRQFISQVRQEIAIRLHARLYPGGVGPSKFWLSFTKRKFMGKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>W6QJX5</accession>
    <name>W6QJX5_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RBR-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PROQFM164_S03g001248</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.31"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.3.2.31" evidence="2"/>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QJX5"/>
    <dbReference type="STRING" id="1365484.W6QJX5"/>
    <dbReference type="OMA" id="QTECAHT"/>
    <dbReference type="OrthoDB" id="9977870at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22584">
        <property type="entry name" value="Rcat_RBR_unk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031127">
        <property type="entry name" value="E3_UB_ligase_RBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11685">
        <property type="entry name" value="RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01485">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00647">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="12">
        <location>
            <begin position="66"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="11">
        <location>
            <begin position="70"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="204"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="224"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDM34524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="299" mass="34397" checksum="D549F2F1BFDDB716" modified="2014-04-16" version="1">MTQLGELMSKIRGRIFTRGAALSLDKELEQKASSNPKMQGKMSAVPGEYVISDDSDEDLLDEGLDDQYECTCCTEKYPQSDIIQTECAHTYCRECIVRLFENALANEASFPPRCCRLPIAVSITVEDMIGIEIMKRYKERNTEVNDCHRTYCSNSPCSRYIPPQNIRRGVGICQSCAARTCADCKRQGHRGNCNHQNTEKCKRASKAKKRKRVSKVKKRKRASNAKERKSASNEKAKQAYDDEMNDNLLERLANRKKWKRCSNCSRMIEHIDGCMHISCLCGWEFCYVCGEKWRNCRHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W6QK31</accession>
    <name>W6QK31_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Probable transposable element</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S06g000139</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792020">
        <property type="protein sequence ID" value="CDM37178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QK31"/>
    <dbReference type="STRING" id="1365484.W6QK31"/>
    <dbReference type="OMA" id="LEWCVEV"/>
    <dbReference type="OrthoDB" id="5379619at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038717">
        <property type="entry name" value="Tc1-like_DDE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46564">
        <property type="entry name" value="TRANSPOSASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46564:SF1">
        <property type="entry name" value="TRANSPOSASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13358">
        <property type="entry name" value="DDE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tc1-like transposase DDE" evidence="1">
        <location>
            <begin position="22"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM37178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="161" mass="18641" checksum="3D1CF636467668C7" modified="2014-04-16" version="1">MDESGYDKRIGFRRTGWSPILPAYAQDGVVFSQVFRGSTDASVFEDFIKQLLRHCGKWPEPKSVLVIDNASFHHSERIKEICATVGVKLVYLPPYSPDLNPIEEFFSELKAFIRRNWRRYEQRPDQGFASFLEWCVEVVGSRERSATGHFRHAGVVVEDYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W6QL50</accession>
    <name>W6QL50_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S06g000535</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792020">
        <property type="protein sequence ID" value="CDM37573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QL50"/>
    <dbReference type="OMA" id="IGWEDDF"/>
    <dbReference type="OrthoDB" id="5345334at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM37573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="100" mass="12151" checksum="0D2A21EB3A4ED25B" modified="2014-04-16" version="1">MVKPVKVQYIGWEDDFRYAEEKSRITEHIQKIAEDNGFSHALVQDMIMRYRYRSQGPWIDVHFKREQWVTNGVGKYVFTRLWFNEDGDLDKDPEFFEVEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W6QLC3</accession>
    <name>W6QLC3_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S05g000604</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QLC3"/>
    <dbReference type="OMA" id="SICSRDA"/>
    <dbReference type="OrthoDB" id="5410926at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39599:SF1">
        <property type="entry name" value="GPI-ANCHORED PROTEIN (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39599">
        <property type="entry name" value="GPI-ANCHORED PROTEIN (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004879931" evidence="1">
        <location>
            <begin position="24"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM36771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="255" mass="25883" checksum="D225AAF8DD677008" modified="2014-04-16" version="1">MRTSRWIWIAATFLASTVHSTKTAPFTAAEAAIANKRAFEVLRILRRADNNCPSGYNPCTDLGNGDACCKQGTNCSRDAANNIACCASGASCTGSLTGTTTTGTGTAFMFPSGATATTTTEGETSATGSTLDAAYPFVVVPTSFGNAESCSSYYSVCQSEYTQCTGALMGRYGVTIDGAGGGVTVEAVTASSQATSICSSLSLEACHGINLGYCSSVATQTASAEANGNDASPVRMSSLHDLVFGLAVGVAGMFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W6QM77</accession>
    <name>W6QM77_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cytokinin riboside 5'-monophosphate phosphoribohydrolase LOG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S06g000502</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792020">
        <property type="protein sequence ID" value="CDM37540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QM77"/>
    <dbReference type="STRING" id="1365484.W6QM77"/>
    <dbReference type="OMA" id="ALDWGQE"/>
    <dbReference type="OrthoDB" id="414463at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016799">
        <property type="term" value="F:hydrolase activity, hydrolyzing N-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009691">
        <property type="term" value="P:cytokinin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.450:FF:000018">
        <property type="entry name" value="Lysine decarboxylase-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005269">
        <property type="entry name" value="LOG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031100">
        <property type="entry name" value="LOG_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00730">
        <property type="entry name" value="Rossman fold protein, TIGR00730 family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31223">
        <property type="entry name" value="LOG FAMILY PROTEIN YJL055W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31223:SF70">
        <property type="entry name" value="LOG FAMILY PROTEIN YJL055W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03641">
        <property type="entry name" value="Lysine_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102405">
        <property type="entry name" value="MCP/YpsA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM37540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="243" mass="25892" checksum="9AC67A25F246990D" modified="2014-04-16" version="1">MADSETKPAVVCVFCGSVPGNSPVHMEAARALAEEFHKNNVQLVYGGGTTGLMGEVARTLVSLSGPKSVHGIIPRALVEVATVGGMRQHMETQSTAKQAGKAAERVVDSDAVHTGGIPESEYGITTIVADMHTRKRLMATKVLEGGPGSGFVSLAGGFGTIEEVMEMTTWNQLGIHKVAVVLLNINGYWDGLLAWVRNAVQEGYISASNGEILAEAKEVSEVWPKLLAYRVSTGRMQLNWGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W6QN10</accession>
    <name>W6QN10_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S10g000077</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792024">
        <property type="protein sequence ID" value="CDM38263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QN10"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM38263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="54" mass="6346" checksum="4AE048ADF18681CE" modified="2014-04-16" version="1">MNPRHLRPTETAILAEYTIVKQRTSWPFWDKAGYGGRTLYVARSVFRTYIRSAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W6QNC3</accession>
    <name>W6QNC3_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Peptide chain release factor class I/class II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PROQFM164_S06g000423</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the prokaryotic/mitochondrial release factor family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792020">
        <property type="protein sequence ID" value="CDM37461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QNC3"/>
    <dbReference type="STRING" id="1365484.W6QNC3"/>
    <dbReference type="OMA" id="IIWDDDV"/>
    <dbReference type="OrthoDB" id="277888at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003747">
        <property type="term" value="F:translation release factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000065">
        <property type="entry name" value="Peptidyl-tRNA hydrolase domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052405">
        <property type="entry name" value="Mito_Transl_Release_Factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46203:SF1">
        <property type="entry name" value="MITOCHONDRIAL TRANSLATION RELEASE FACTOR IN RESCUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46203">
        <property type="entry name" value="PROBABLE PEPTIDE CHAIN RELEASE FACTOR C12ORF65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75620">
        <property type="entry name" value="Release factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Prokaryotic-type class I peptide chain release factors" evidence="6">
        <location>
            <begin position="36"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="118"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="118"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="133"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="144"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="158"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM37461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="186" mass="20247" checksum="282DE6DA7CD5DE87" modified="2014-04-16" version="1">MLSRLRWRTLSPTLAAPARLFSQTPIIPEKALPPRLKINDADISISYLKGTGPGGQKINKTNSAVQIIHKPSGVVIKCQATRSQAQNAKIARSLLADRVEALQKGDSSRVAIKAAAAKKKKASKMKKTRRKYRELAEGEKEGEVGEEEEDEVEIIWDDEVKGGENKEAESKIGGEAKTSEESGKGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W6QNN1</accession>
    <name>W6QNN1_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S06g000533</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792020">
        <property type="protein sequence ID" value="CDM37571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QNN1"/>
    <dbReference type="STRING" id="1365484.W6QNN1"/>
    <dbReference type="OrthoDB" id="1937899at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM37571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="61" mass="6952" checksum="078040B8D0893386" modified="2014-04-16" version="1">MLFMDALELDLVDSGHAHSGVSIPDLILACLYRELVKAYTSFSSHCYRNVRKPYSFVTTRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W6QQ56</accession>
    <name>W6QQ56_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Probable transposable element</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S30g000002</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792044">
        <property type="protein sequence ID" value="CDM38601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QQ56"/>
    <dbReference type="STRING" id="1365484.W6QQ56"/>
    <dbReference type="OMA" id="HCHRSSE"/>
    <dbReference type="OrthoDB" id="3261222at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM38601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="246" mass="28109" checksum="08B479553E1A4AB8" modified="2014-04-16" version="1">MWTDIYTLPKTNPLRRAGGLIQIAVSSSAQNELVGFGVTIEKQPPRNRKLKLKTFSITLGARAKQNPFSAELAAMAHILKMIVGIKDYRTTLLTSNKAAVLTLRNPRRHELPENIGRHTKRVDAALPGKHTRQLYDRLTWKEASVLAQLRTGMARLNRYLNQINIAETDQCDYRQARETVEHFLFRYRKWMTHRTEMLQCTQTHRGNISFFLGGKQPSDDQKRTPNLEAVQASIRFAIATGRLEAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W6QQC4</accession>
    <name>W6QQC4_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Dimeric alpha-beta barrel</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S05g000082</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QQC4"/>
    <dbReference type="STRING" id="1365484.W6QQC4"/>
    <dbReference type="OrthoDB" id="3450712at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM36249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="238" mass="27510" checksum="F3DF6C296AEB1D53" modified="2014-04-16" version="1">MPDSNLFSNTGLPERFVLTKLQVPGELDDAQLTEYFQPLLHTPGHNRSMWGMIQDKPKTALLATLWETTDAIKYFQDSPSAQLLWETLAAKNIIIFSSHETPYVGNWFEVLDSSFIQLFWVYFQAPVTDAQRTEISKLRGLRPPASGFSVPRHHRPQTEIPTKAWATQPESNATQLMLWPHFWRNSEKSEWRHGLTEVLFGSTIIGKRSRIDDFDARLQEVGSVKWTEDFCSFRRIRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W6QQX8</accession>
    <name>W6QQX8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Src homology-3 domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PROQFM164_S02g002103</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QQX8"/>
    <dbReference type="STRING" id="1365484.W6QQX8"/>
    <dbReference type="OMA" id="EWWKGRN"/>
    <dbReference type="OrthoDB" id="6250593at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00174">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050670">
        <property type="entry name" value="STAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45929">
        <property type="entry name" value="JAK PATHWAY SIGNAL TRANSDUCTION ADAPTOR MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45929:SF7">
        <property type="entry name" value="LAS SEVENTEEN-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="124"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="51"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="184"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="61"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="81"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="213"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDM31952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="252" mass="27089" checksum="2302C8660BCA28CE" modified="2014-04-16" version="1">MAPTVKFASAMTTRSLRMVRTELEFLADASVITPNQLSTILSQLPADSEVSRALQASPSEQAQPAPVQQVPVQAQPPPAPYSNTPSYSAPVSQMSNMSVNEKAALNNQYASPPPQAPPSYLQAPPLRLAVAMYEFKSTDPGDLDLKPHDRVQITEEINAHWWRGRNERTGQEGIFPGSYVDEKAALASPPPQSTDYGNMPLAVSQSGQPENPEDPKKNKFEEGGKKFGKKLGNAAIFGAGATVGSNIVNSIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W6QR93</accession>
    <name>W6QR93_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S02g002218</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QR93"/>
    <dbReference type="STRING" id="1365484.W6QR93"/>
    <dbReference type="OMA" id="NYDGNRK"/>
    <dbReference type="OrthoDB" id="67027at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="255"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM32067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="602" mass="67560" checksum="3DCE4A13D77580BD" modified="2014-04-16" version="1">MSKDSVEFIRKLVACPELTESDIDVALTAAGVDELLPDGNRKLSQLGLAATGFLIDSSIAFITLSRDFTSKLKSRVNGIQHRADIAKRTGIDKHLKFDCRTGARSSGVLAIATSALIGAIYLRKKCFMSVAKGLYSLGVLDEHLDQLNLMEIFKDEQRNPLLLPSLVESDSAQTSEIWSQDIPPWPDFPTTPDLGGLSNYERLYNENGLLKDILPDGLSFTDSRSQSPLADDPGQRALERQVLGICHPIAYQEMHHGRPHEPDGFSGQPANQRSSSQHFPRKRENASGMEVQKRKSRCVDIEFRSSLCREAELTRALGLPPPGDTYFRPKIEDKILSLGSEIFSSLSTFLILVGGSQSLVTLRAALKYTRELGDQGPIVQRRRWVSRELTIHERFEIIGEIQDNAAFLQILRCNHILHFYRCTCSPVERTSKFIELASKDELIGQPRARGNPRKMEVAKVVNEMMRDVFPDLEPNSAVYKSKRRKMLGFRKFGQRLHILADCFGDAVLSILHFDRSGDVAGPVIIEKIILAPSDEAFETFVKVLEESQGSLLREISKAAEQAFNHILYEDMKRQNLFALETLAPEEILKFPKGSQELRNLLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>W6QRV5</accession>
    <name>W6QRV5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Zn(2)-C6 fungal-type DNA-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PROQFM164_S05g000632</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QRV5"/>
    <dbReference type="STRING" id="1365484.W6QRV5"/>
    <dbReference type="OMA" id="ISVAHCQ"/>
    <dbReference type="OrthoDB" id="5600212at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF10">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="54"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="653"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="10"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="29"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="676"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="705"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="748"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="777"/>
            <end position="792"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM36799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="891" mass="98301" checksum="C5F08D01FA29DD52" modified="2014-04-16" version="1">MAAPPASTFGPESSQYSTEFGPSQMEFMSSESGAAAESTSTGETNFVPRPKRIACVVCRRRKLRCDGRRPSCGTCSRLGHECSYDEVRKKSGPKRGYVKQLEARLETLLKVQDPEPTQRTSQPQPLENAFTAPIADESILDLPDLSDLGGLAGIGGNMDNSFSASIAPGAGQPSQILYPPPPITQGDNSQWDLISLGLEEPLPPQDVIDELDALFFEKIYPMMPIIHRPRYYAALNLAPNMRPPICLRYIMWCNAASVSDKYFFLHSHFYQRARKYAEADEMKGFGENIVSLAHCQTWLFIGTYEFRMIFFPRAWLSVGKAARLALMLGLNRLDGVGLDVKQSILPPKDWTEREERRRVFWGAFATDRYSSVGTGWPILIDENDIMTNLPASEDSFTKSKPQRTLPLNDIIAGEGVSTLAPFACVVVLASLFGRNLIHIHRPQPQDNDHDLNGDFWKRHRSHDNILLHISLSLPDHLRLPSGVSDVNVIFANMSIHTSTICLHQAAIFKAEKNKMPNQITTESKRRCLVAANQISSTMKMISHVDLTSLNPFMSFCLYIAARVFVQYLKSRPDDSSVYSSLQFLVSALTAMKNKNPLTESFLVQLDVDLDGTGIRALDDRQRTNMSAAHSMVQSYCNDKVECTPIYNLRQTQGMAKEVPPQYSTNRGGNQPMPAGLTTSLPSRNRDSTTQPTAGPVFNGDDTSHFFGTSTQATDQAGPPGAIIDTDMDFRSDFGNLSDRNNPPSDHPTPSTLNSSSNTSYSINGADDPPPGNKNRKTNSGYPSQESAQSFDKVNSDIMPQGNTNPRATDLDSMSGRFYPNSSNSPSVAGASGIFSMPSAWDLPPSNPETGNEGFGNLNMEAFSESQWAQILNGQIQGESPINAGWENWRPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W6QTE4</accession>
    <name>W6QTE4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S02g002938</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QTE4"/>
    <dbReference type="OrthoDB" id="10275241at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM32787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="59" mass="6356" checksum="0418D9A2E82677F4" modified="2014-04-16" version="1">MKKTVTVASDHGQNGQSSQSATALSDLIANSMICENHILAVSLSFQQSKKWFTILNAGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>W6QUC6</accession>
    <name>W6QUC6_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Eukaryotic translation initiation factor 3 subunit D</fullName>
            <shortName evidence="5">eIF3d</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PROQFM164_S02g003284</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">mRNA cap-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. In the eIF-3 complex, eif3d specifically recognizes and binds the 7-methylguanosine cap of a subset of mRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="5">The RNA gate region regulates mRNA cap recognition to prevent promiscuous mRNA-binding before assembly of eif3d into the full eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the eIF-3 subunit D family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM33132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QUC6"/>
    <dbReference type="STRING" id="1365484.W6QUC6"/>
    <dbReference type="OMA" id="FMDKRDN"/>
    <dbReference type="OrthoDB" id="16538at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098808">
        <property type="term" value="F:mRNA cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002191">
        <property type="term" value="P:cap-dependent translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03003">
        <property type="entry name" value="eIF3d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007783">
        <property type="entry name" value="eIF3d"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12399">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12399:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05091">
        <property type="entry name" value="eIF-3_zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016281">
        <property type="entry name" value="EIF-3_zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5 7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="105"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="RNA gate" evidence="5">
        <location>
            <begin position="304"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="570"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="106"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="570"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="582"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM33132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="591" mass="65374" checksum="F54BB3196E18E08A" modified="2014-04-16" version="1">MPSTSLADLVAALPLEDTWGPSTSADNMLSGVPYAPFSKGDKLGRMADWTAETKERQNQRPQYNRGFRDQQVYGAGTSNLFTVAAAEDESSFSVVDNTRVQKRGFGRGGGTVFRGRGGQRGAANQRGGRGGFQRAGPNVGRGQQSGYQFSDRGGARGGRGGRRFGWRDYDKPQRIREASVNIRPDWKMLEEVDFTRLSKLNLDAPEGEDLETYGFLHYYDKSYDKPPVKNAERRMQALDRAAYNVTTSQDPVINELAEKNAATVFSTSDILSMLMCATRSVYSWDIVIVHQGDKIYFDKRDGASFDMVSVNENAIDAPLEAAEAAGKQEQINTPNALAMEATIINHNFALQTLIESDKNKVSFAKPNPFYDETEETEPLASKGYKYRRFDISLERDEEPVSMVVRTEVDAVMKGGPTGTEDQQLIIKALNEFDPKAQGSGGALDWRSKLNSQRGAVLATEMKNNSAKLARWTTQAILAKADGMKLGFVSRVNPRSAAAHVVLGVAGYKPREFASQMNLNLGNGWGIVRTIVDRIRALDSDEPADKVKKYVLIKDPNKSVLRLYSVPATTFEEDDEELEEEKEGDKSDEADE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>W6QVA9</accession>
    <name>W6QVA9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Zn(2)-C6 fungal-type DNA-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PROQFM164_S08g000120</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792022">
        <property type="protein sequence ID" value="CDM38069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QVA9"/>
    <dbReference type="STRING" id="1365484.W6QVA9"/>
    <dbReference type="OMA" id="CIHSVLP"/>
    <dbReference type="OrthoDB" id="2110361at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF1">
        <property type="entry name" value="MISCELLANEOUS ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="116"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="28"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="740"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="154"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="87"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="743"/>
            <end position="759"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM38069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="767" mass="85662" checksum="CE331FEBDD45AA4F" modified="2014-04-16" version="1">MQPSHFRGNQGYELPSVQSVTSGAFPAPALLSAPPSRPDSGMRMSHLLQPMPPAAPATSPYQRYYDSASGSPGETTLPDAPSMGSGLYQTSPGHSQQTAAQLQQKRAYRQRRKDPSCDACRERKVKCDASESSSCTECNNRRVRCQFTKETNRRMSSIKQVQDLEKQLQTTKQQLQHLQTGMMRPDRMVDVDEGVSQMIKLSEIEYRPVRRSRAPIPQDFSDVRSNLRDYGQGIMKVPTPYRQQGAESLVTRNAPILPAKKIADQLLAQYFSCIHSVLPVLHWPIFIAEYEKVYRMGSLLGVSNEWAAVLFGVFACGVIHTNDEDREEQGKKYVRTSCGIIDVWHDVFNLDRARAALLASIFLYEVNSKSASWVWIGSAVRVAQEIGLHIDSGPWPAVEGEMRKRVWWGLYAWDRILALEMGKPVLINDQDCDIDLPCPVDEQYITEGGKIPDNQQTTPLLATIHVVRSIGQLTRTLRSATISPATLETFELHFNTCLATFPSQFHPKTDEDLDPRSLAPVIYLQNARLLLHRHNISPFCPDIVRTSALDYCVSTALDTANILSRCMRNYSVRPRPPCIYDPHSHFASSASALLCTHVWRCTLFLLFRGEYGGALVCVKALSAVGDVRTVNAACGRYISFFMRKLLGCIANSSASVPDLDRNEEMMAYVSGDMQGTSDGSWIWHGSETGSQLEGMGAPMPTTSSNYRTEMDTDTDWEGWTWIEQSIGVLFQEQKRQQEENYKASLGSDSASGRSSSAHSRMTIASII</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W6QVW8</accession>
    <name>W6QVW8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Rap1-interacting factor 1 N-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PROQFM164_S03g000441</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1365484.W6QVW8"/>
    <dbReference type="OMA" id="FMTPPHL"/>
    <dbReference type="OrthoDB" id="5399929at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140445">
        <property type="term" value="C:chromosome, telomeric repeat region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022031">
        <property type="entry name" value="Rif1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22928">
        <property type="entry name" value="TELOMERE-ASSOCIATED PROTEIN RIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22928:SF3">
        <property type="entry name" value="TELOMERE-ASSOCIATED PROTEIN RIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12231">
        <property type="entry name" value="Rif1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0779">Telomere</keyword>
    <feature type="domain" description="Telomere-associated protein Rif1 N-terminal" evidence="8">
        <location>
            <begin position="129"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1049"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1143"/>
            <end position="1620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1645"/>
            <end position="1675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1074"/>
            <end position="1088"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1174"/>
            <end position="1184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1237"/>
            <end position="1255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1262"/>
            <end position="1280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1341"/>
            <end position="1356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1405"/>
            <end position="1421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1470"/>
            <end position="1485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1501"/>
            <end position="1519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1537"/>
            <end position="1551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1562"/>
            <end position="1574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1579"/>
            <end position="1593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1601"/>
            <end position="1619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1651"/>
            <end position="1666"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM33717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="1725" mass="189291" checksum="9FF164DBA88988FA" modified="2014-04-16" version="1">MVEILPARPPTPPRTTSRIVIENAESPPAVQTPNESPFSALGSVQVGPSSRSSKKVNFSPWPKYIKPPTFASAMKSAPDFKTIPPSPNSKPTKSILKATQSPIPVWSPNVDTFTAESLAMLLESVIQQLAGESMSSRLDAYMQFYGALRTYNGLPAGQKIAEKLNLITEFIQRDVNRDFANGSLLDTNLANQALKLSISFVWNPEISTQLSEEFKIFLVDHSITCLHEAKAPKSVLIHYMSILSNQSFGPKIMTGARVARLLTVLQDINKNISGNSIVSHRLNIYQRLLGQAKSAFISQASLWMENLIFGLLHTLKDTRSKSISFGFQVATDAGPNPILSKNIRDLFDRPLEHDRKLVSEIRERMTRMMATDSGEHVPQIWSIIILLLRSKRWNFEQWEHYKEWVLVLQKCFNCSEPVIKAQAIVGWNRFVFAVSPNESTSRSLLKMLGKPVLSQFDRKKADKSGAPPTQLALTSYYNLLYYTFRPSASYQHLDIIWEEYVAIPSAGIFSSAPVLSDCLARILANLLWSTQAKIWVENRINDTTKMEAEELPAADSRWVRSRITSILKVFEHIFKASVWVDGAVGQSHVALAWSSLSSALSIASSKEITPSGESMQAVASVWSLMHRLWNAGSPSLNAGTTDEFFERFRFLSTTMIVSIGGIPFTEKLLLRNADETESISIHSPPNTTQESAILHLLRIISSTAGTMVPSQSYKLLVLCNIEAACNGRFSRGTRLELLQQCAELSTSKASAIPRAAQLSEVVWNATAQVAADSLQSFPMESARGRDGSVSRDYENVIKILSLGLSFPSAFEGWSHLLETFVRVVRTEKGNQAVATMIVEPMAERLMYLCAGDTYLPSTSLLGHSLSIPFMQGTGLGIDRSGIQAAGHVIFPHKLIASTAQTLHDAYHNFNASQSHGLADFIEALTSFLGIGVPQFQSQILQNLQSSLGLWLKDESYKIHVDHGVDSRILTACRALSSATINILQKSVSHDLASLKIFEPIICAGLESSHMSIAKRYVELWGLTFGSQSLATPVTILQAVQTASSRLQTATLPPQDGDQDTEMSPPSPQDKMNRSLHQPSQDTQLSSPVIRTEDSSVAIKPTEQFHEPQLPSNLHQPTDAQIIDGVSVSHKRKSRSEMFSMIESIQSSSPASTPRKLGFDTPPHLPKLHGESKTELPLTPTLAPTENEEGFIGSSPTPGTRDPTPAMNSDALTSGHLLADLGMDPPSSPPDMQSRSPSPRKSRSKSARRKAAKARKALVGISGKQSTVNSPATSHLATENIDTPMGNAYDYDNENADTAPRVNGMTPSRQLRSALGKNPDTEEPSAVPLVDSDKTPVQQPTRRSKSSSGSKKKRKQSQSKPADDRPQEAADMPSVIPPDGFMDSSEETETQVASQLGQDLELALDMEDRGHLERTKLPDEPSRKKRKRNQMESSPTMRTDRRRSSRLSTVKDVVSVELLQPDDSHSHHVISQSASPAPSLSPTATRRSTRSSQRKYADDASTDSVPATQSSVVQESTQDAETPRPSKRTRKSIHLEDQSVSSTIGSTPQGVSRDTRSRKTRHQQASQPQPSSIASEENGDTDRLPPDVSLDRIPESLITEDQAGQNTSLVSTEEATATQVSEREQAIEFAVKLDPEEDINMNAVQQSGGTVEQTTSIATTGTQTQETPPEPKSDISEQGIVQSLKNLLGEMKMTTLSPSAFREVDDLLFNLRCEAQNASTRHNTSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W6QW94</accession>
    <name>W6QW94_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Cyanide hydratase</fullName>
            <shortName evidence="7">CHT</shortName>
            <ecNumber evidence="2 7">4.2.1.66</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Cyanide-degrading nitrilase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Formamide hydrolyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">CHT</name>
        <name evidence="10" type="ORF">PROQFM164_S03g000481</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the hydration of cyanide to formamide. Degradation of cyanide may be important for plant pathogenic fungi in infection of cyanogenic plants.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>formamide = hydrogen cyanide + H2O</text>
            <dbReference type="Rhea" id="RHEA:21720"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16397"/>
            <dbReference type="ChEBI" id="CHEBI:18407"/>
            <dbReference type="EC" id="4.2.1.66"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Oligomer of dimers, forming left-handed helical fibers.</text>
    </comment>
    <comment type="induction">
        <text evidence="7">By cyanide.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the carbon-nitrogen hydrolase superfamily. Nitrilase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.66" evidence="2 7"/>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QW94"/>
    <dbReference type="STRING" id="1365484.W6QW94"/>
    <dbReference type="OMA" id="TSEPCWF"/>
    <dbReference type="OrthoDB" id="10250282at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030196">
        <property type="term" value="F:cyanide hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000257">
        <property type="term" value="F:nitrilase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019500">
        <property type="term" value="P:cyanide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07564">
        <property type="entry name" value="nitrilases_CHs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.110.10:FF:000011">
        <property type="entry name" value="Cyanide hydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03224">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037544">
        <property type="entry name" value="CN_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000132">
        <property type="entry name" value="Nitrilase/CN_hydratase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044149">
        <property type="entry name" value="Nitrilases_CHs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46044:SF4">
        <property type="entry name" value="CYANIDE HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46044">
        <property type="entry name" value="NITRILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00920">
        <property type="entry name" value="NITRIL_CHT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="9">
        <location>
            <begin position="8"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDM33757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="357" mass="39899" checksum="EA9BAB7AD8066C67" modified="2014-04-16" version="1">MVTVLKKYKAAAVNAEPGWFDLQESVRRTIHWIDEAGKAGCKLIAFPELWIPGYPYWAWKVTYQESLPLLKKYRENSLASNSEEMRRIREAAKANKIWVSLGYSELDLASLYTTQVMISPAGDVINHRRKIRATHVERLVFGDGTGDTTESVMDTELGRIGHLNCWENMNPFLKAYAASLGEQVHIAAWPLYPGKETLKYPDPYTNIAEANADLVTPAYAAETGTFTLAPWQTITAEGIKVNTPPGKELEDPEIYNGNGRIFGPDGQNLVPHPAKDFQGLLFVDIDLDEIHLSKALADFGGHYMRPDLIRLLVDTNRKDLVVREDKANGGVIYTRTIDRVGLSLPLDSSAPEPETEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W6QXC1</accession>
    <name>W6QXC1_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="5">S-crystallin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PROQFM164_S03g000931</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the GST superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QXC1"/>
    <dbReference type="STRING" id="1365484.W6QXC1"/>
    <dbReference type="OMA" id="IKPIQLY"/>
    <dbReference type="OrthoDB" id="422574at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03048">
        <property type="entry name" value="GST_N_Ure2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051:SF23">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE-LIKE PROTEIN TPCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="3">
        <location>
            <begin position="6"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="4">
        <location>
            <begin position="96"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDM34207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="237" mass="26729" checksum="A52CCE0BC0478291" modified="2014-04-16" version="1">MSPTIKPIQLYGGILGPNPLKVGIILTLLEVPFESVPVGFAQVKEPEYEAINPNGRLPSIHDPNTNLTIWESGAIIEYLIERYDTNEPRKLSFTPGSAEAELARSFLHLQVSGQGPYYGQAYWFKRYHAERLPSAVKRYVEEAKRVTGVLDKWLGKQKEANDKHVGDGPWLVGNKMSYADIAFIPWQKAAHTVLVDEGFDVDEFPNEKQWLERMISKEPIKAVLDSADEQMASMSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W6QZ52</accession>
    <name>W6QZ52_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S03</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S03g001539</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QZ52"/>
    <dbReference type="STRING" id="1365484.W6QZ52"/>
    <dbReference type="OMA" id="YPMLKKF"/>
    <dbReference type="OrthoDB" id="408152at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040632">
        <property type="entry name" value="Sulfotransfer_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36978:SF4">
        <property type="entry name" value="P-LOOP CONTAINING NUCLEOSIDE TRIPHOSPHATE HYDROLASE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36978">
        <property type="entry name" value="P-LOOP CONTAINING NUCLEOTIDE TRIPHOSPHATE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17784">
        <property type="entry name" value="Sulfotransfer_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="258"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM34812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="286" mass="32438" checksum="2B359681B2CCDAD3" modified="2014-04-16" version="1">MSLMLSDNLAPQPITDVFTNDTNINRRKCHRTVPMKVLALGVGRTGTASLRKAFERLGYGKCYHMMCASVENPPDCLMWHDALNAKYDGVGEFGRKEWDQLLGDCQAVCDWPACAFAKELIEAYPNAKVILTTRDVDPWHASVMKTVFWRVSDPEHKFVSNFSWAAGMYYPMLNKFFETFFRGDFPGKGKQVYEDHVAQVRSLVPPERLLEYNINDGWAPLCEFLEEEVPDTPFPRGNDMADFYKRCSTRNRHQMMNVALQAVTVGGSLLAAGLAATLAFKRFSPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W6QZK6</accession>
    <name>W6QZK6_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Prenylated rab acceptor PRA1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PROQFM164_S03g001724</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QZK6"/>
    <dbReference type="STRING" id="1365484.W6QZK6"/>
    <dbReference type="OMA" id="AYAFWAW"/>
    <dbReference type="OrthoDB" id="63113at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004895">
        <property type="entry name" value="Prenylated_rab_accept_PRA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19317">
        <property type="entry name" value="PRENYLATED RAB ACCEPTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19317:SF0">
        <property type="entry name" value="PRENYLATED RAB ACCEPTOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03208">
        <property type="entry name" value="PRA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="68"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="112"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="279"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="334"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="292"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="303"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="336"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="436"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="481"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="508"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM34997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="528" mass="58172" checksum="23DDDE3BE7B38A89" modified="2014-04-16" version="1">MVSIPIDAITSRFGDRLNNFRSTSLTTRFANLRPISEFLDVKRLSKPANFGEAQSRVNYNLSYFSSNYAVVFVMLSIYSLLTNLVLLFDMIFISCGIYGINMLQGRDLDLGFSRFTTSQLYTGLLIIGVPIGIWASPFTTALWLIGATGVTVFGHAAFLDKPIENAFSEEAETRLEEVDSEEDAYGRELVRSGRYREYGGRGLRRRPVDYEDLTDESEVDGGEFDLYDHEDSTVAYAIQLAMRDKEDQLVDTALERIRRAQVLGKKNVRLSKPELDALERKRQQADGLSGSRRPSTSSVKVTSRPSSRRSAVVAPDQMSGAYPTFADAHSIWARGTGANSRPSSSSSAPRPGTPTTQSLRPQQSSSPLRPTYPPYTPERFAPSGRPQSMQQPPVFQRPLPDDPQWAPPYYNTMQMSSYGEPAAYPPQAATAGQRMSYPSGSAYPSYQSQSPGKRSLQGTPQARTDPAPAPAPAPSKLGSEESSEESESSSEDEVQIVKVAKVAERKAPPAAVAQRRPVTGTTRKRTSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>W6R1D4</accession>
    <name>W6R1D4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cell division protein GTP binding</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PROQFM164_S04g000518</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6R1D4"/>
    <dbReference type="STRING" id="1365484.W6R1D4"/>
    <dbReference type="OMA" id="KPYPPWW"/>
    <dbReference type="OrthoDB" id="4150765at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046707">
        <property type="entry name" value="DUF6780"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18884">
        <property type="entry name" value="SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20571">
        <property type="entry name" value="DUF6780"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51719">
        <property type="entry name" value="G_SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="1" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="677"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="domain" description="Septin-type G" evidence="4">
        <location>
            <begin position="215"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="60"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="106"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="64"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="81"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="136"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDM35637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="721" mass="78977" checksum="DEB6F98F4DCF15D6" modified="2014-04-16" version="1">MRPTPDLPFSRKPSDHPPSPSLDPRTATPATFFLSRNPHVADWDSSISIDSPEDVKENMYGVQSLDTSLSQSEFPSWPRNHSAEDSLKQATDDLESHLAQCRSTLKPLNSDTGESSEHASPAHTVSRPVTPLTLGIPDDPSSLPSSPKSISNQSLRPLDDISITDEINSQAIGSGDEDEMPHESPFLGPGGAASQLIMPSIKMPSRRPFTERGKAMGRFKVLLAGAPGSGKTSLIKSIVQTCDDIVHVDAIPQMTSSGRRRSCRPRSRGRSTATMEIYASTKPYPSWWSDLEDSRVLQRRKSMGEIVLERNLCFVDTPATNLSRAGQSDAIGEYMRQQFFRATTALSGSSVDFQNLLAGNGGSQVDAILYLISTDTLSTDVECIRKLCELSNVIPIVSKADTLTPTQVTHLKVRFHEQAREAGIKPFLFGDLPNGQDGLESQPPYAVSSEKSVDAETMDASTLMSPDYVQPLIPSELDALVTKMFDRDNLAWMRHSAAKKLLQQRTDSYSLPSSMPLPSAQLGPTANGSEYAYSSWRSVTGTSMSPGSPPGYAMARIADYTRHEERMAQVRLAQWATDLQRSLQNERNRYTSIARGERAIWLTERLGECVIDGSLVPLSQTPGFCGLHGPIDEKSPGGFQVMRSHAGSGAAYRFAKFSPHDPLGVVGWIDELGHRSWMLVQIVGSVGVVGGLALWLARTWGFPTRSLSDFRVDYWCGTMER</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W6R1I8</accession>
    <name>W6R1I8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type DNA-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PROQFM164_S04g000573</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6R1I8"/>
    <dbReference type="STRING" id="1365484.W6R1I8"/>
    <dbReference type="OMA" id="TYFASYV"/>
    <dbReference type="OrthoDB" id="5418899at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF9">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="6"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="103"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="146"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="441"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="154"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="167"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="448"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM35692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="756" mass="84033" checksum="A3B7489628C0138F" modified="2014-04-16" version="1">MRSRTGCLTCRTRKLKCDEEKPECSQCRKGGRECRPSEGVVFRHQQNASMNRNSPDGRGSLNGFYSYKNTFDKDSVWLDVPKHVIFVDNSDPYADDLEASLLDPGSAAQTNSPNHRWDSGGPRASDAETQGLEALSAVATHDRFPYSPLDHSISDSTSYTSPNPQRSAAITPASPSISLSSTSNNTNINFLLNPAHSMSPSIDPSMQLSDRNNALPSRPAASQRSMSHMSHMSLVNHTTDDNSETDFETAFLLRHYSEGPGLWMDLFDLGTYFASYVPVRARTNPLLKFAACAYSAKQLGRVKGAKASVGGVCTQQSAMELWPDKDPDFAWYGAKYYEKAIQLLMKELQPDAEGPPPLSTPEAFGQWQAAEISVDSDNPRKRRRRVSDSRLSHGVHSDEVLAATAILSVYEFLDAAGPAWNRHLSGVKSLLDVAEVGMMPLEQRPSPGESSYQTQTPKKSGLSKARKATFWNFARQDYLAAFINECHTRLNTDDTVLWTEAGLLLDNAGFVRASNTSAAGYPEGEDVMKEDLISNGLVWILSKIVNFISSGDNLHISGSVPGPLGVSQQALLERWYRLESELDAWYTGIPETFRPCARIDASNLTHHRPPDEHEDISTLQEIWYSLPMCASAMQHYHMARILLLINKPHESTSRRSTITLRLQSYRSIESEIAFHSREIVGIGLSRPDGSVRINSLQPLFVSGQCLTDPRERRTTVRLLRSIESDLGWATEYRVQQLLKEWGWDENSTRSPGSSCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>W6R3G3</accession>
    <name>W6R3G3_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNA exonuclease 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">rex4</name>
        <name evidence="12" type="ORF">PROQFM164_S05g000175</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Exoribonuclease involved in ribosome biosynthesis. Involved in the processing of ITS1, the internal transcribed spacer localized between the 18S and 5.8S rRNAs.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the REXO4 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6R3G3"/>
    <dbReference type="STRING" id="1365484.W6R3G3"/>
    <dbReference type="OMA" id="SQKEMRF"/>
    <dbReference type="OrthoDB" id="8191639at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06144">
        <property type="entry name" value="REX4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000007">
        <property type="entry name" value="Interferon-stimulated exonuclease gene 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037431">
        <property type="entry name" value="REX4_DEDDh_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047021">
        <property type="entry name" value="REXO1/3/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801:SF45">
        <property type="entry name" value="RNA EXONUCLEASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801">
        <property type="entry name" value="RNA EXONUCLEASE REXO1 / RECO3 FAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Exonuclease" evidence="11">
        <location>
            <begin position="99"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="269"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="17"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="43"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="81"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="273"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="283"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDM36342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="294" mass="33223" checksum="12EA74D1270E01F5" modified="2014-04-16" version="1">MDKTALSSNWKKLQATLKKDPTVKRKPSELDSGNGIVKKRKLTEKQKPYNRDAKPTLKRKRMSDKKETGDSADASAPKIETSSRHKENEGRSPSAELGKYVAMDCEMVGVGPNPDSDSALARVSVVNFNGDQIYDSYVRPKEMVTDWRTHVSGIAPKHMVEARALEHVQKEIADILKDRILVGHAVSNDLDVLLLSHPKRDIRDTSKHPPYRRIAGGGSPRLKILAEEFLGIKIQDGAHSSVEDARATMALYRREKDAFEREHLKKWPARMIADNREKGEGQKKKKKKKTTRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W6R4B9</accession>
    <name>W6R4B9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-repair protein, UmuC-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S05g000490</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6R4B9"/>
    <dbReference type="STRING" id="1365484.W6R4B9"/>
    <dbReference type="OMA" id="MFKRQDE"/>
    <dbReference type="OrthoDB" id="447129at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070987">
        <property type="term" value="P:error-free translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1170.60:FF:000006">
        <property type="entry name" value="DNA polymerase iota"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000067">
        <property type="entry name" value="DNA polymerase iota, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.100">
        <property type="entry name" value="DNA polymerase, Y-family, little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036775">
        <property type="entry name" value="DNA_pol_Y-fam_lit_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017961">
        <property type="entry name" value="DNA_pol_Y-fam_little_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001126">
        <property type="entry name" value="UmuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46404">
        <property type="entry name" value="DNA POLYMERASE IOTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46404:SF1">
        <property type="entry name" value="DNA POLYMERASE IOTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00817">
        <property type="entry name" value="IMS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11799">
        <property type="entry name" value="IMS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50173">
        <property type="entry name" value="UMUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UmuC" evidence="2">
        <location>
            <begin position="12"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="498"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="511"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM36657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="563" mass="63275" checksum="B92F628C873E4236" modified="2014-04-16" version="1">MAALVRNDDRIILHLDYDCFYASVFEVEQPALRSLPLAVQQKHIVVTCNYEARRRGLHKLQLIKDAKRICPDVVIVLGEDLTKFRNASKELYLLVRSFVWGGRVEKLGFDELFLDVTEMIDYNAGVLNRNDLTNSYFHLDRNDPTVGFSYDATRFQGSTFPATEAAAQNDSSSLEMRLLVASHLQGHIRSKIEHQIGFTATGGISTSKLLAKLVGNVHKPNGQTTLLPPYTATENNTSNVFQFLDDHEIRKIPGIGSRIAEKLKSHIIGKESVGEKITVKDVRQFSGMSPSLLERILGGPGSVKGIGMRMWNILHGVDSSEVLEGRDVPTQISIEDSYGRLDTLESVRRELVVLSRSLIRRVRTDLLDMSDDTAPQGRWRAHPRTLRLSTRPRLPADLGTRRAYSSNRISRSAPLPPFIFNLDENIDALAVRLVRESVFPMFRKLHPEKAGWNLSLLNVAVTNMVETAGDQKRSSGRDIGKMFQQQETVLKDWTVQEPEPSFANPQLPDSPEIESQSDDGWDDDEPWSVDCPICGVSIPHFAQLAHQIYHGDHESQPSIIRQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W6R564</accession>
    <name>W6R564_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S05g000800</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6R564"/>
    <dbReference type="STRING" id="1365484.W6R564"/>
    <dbReference type="OMA" id="LKHWPTD"/>
    <dbReference type="OrthoDB" id="2107880at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061671">
        <property type="term" value="C:Cbp3p-Cbp6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034551">
        <property type="term" value="P:mitochondrial respiratory chain complex III assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037653">
        <property type="entry name" value="Cbp6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28250">
        <property type="entry name" value="CYTOCHROME B PRE-MRNA-PROCESSING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28250:SF1">
        <property type="entry name" value="CYTOCHROME B PRE-MRNA-PROCESSING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20180">
        <property type="entry name" value="UQCC2_CBP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM36967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="119" mass="13504" checksum="D335A2EBCA26E2DB" modified="2014-04-16" version="1">MAKAPALNPRSLQSRLTHILKHWPSDAVRPASVSVQAYIESRLKSADKSGPAISESSVNALESLLNNRYARKYPMPEKLRRPASNPDHYDNVIREFAEAPNRDWFGRLRKRLAGIIRLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W6R7N9</accession>
    <name>W6R7N9_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GTP-binding protein 8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PROQFM164_S07g000205</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792021">
        <property type="protein sequence ID" value="CDM37857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6R7N9"/>
    <dbReference type="STRING" id="1365484.W6R7N9"/>
    <dbReference type="OMA" id="LCYYWDT"/>
    <dbReference type="OrthoDB" id="391988at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01876">
        <property type="entry name" value="YihA_EngB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001874">
        <property type="entry name" value="GTP binding protein (EngB), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00321">
        <property type="entry name" value="GTPase_EngB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052279">
        <property type="entry name" value="EngB_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030393">
        <property type="entry name" value="G_ENGB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019987">
        <property type="entry name" value="GTP-bd_ribosome_bio_YsxC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03598">
        <property type="entry name" value="GTPase_YsxC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46498">
        <property type="entry name" value="GTP-BINDING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46498:SF1">
        <property type="entry name" value="GTP-BINDING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51706">
        <property type="entry name" value="G_ENGB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EngB-type G" evidence="8">
        <location>
            <begin position="88"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM37857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="312" mass="34039" checksum="03E9A1858C69EB1E" modified="2014-04-16" version="1">MNSIPACRNPASRISLYTTIRALSSASNPHSKRELKDLTPTDLCYYWDTRPPKEEQLAFADKVFTPSRHSPLKLWSAAKFRTTPFASVEPEVAFLGRSNVGKSSLLNAIMGQEICWTSSKPGRTREMNAFGIGGTKGGESKVVLLDMPGYGKASRSEWGAEIMKYLQGRKQLRRAFLLIDSTHGIKQTDAEILRLFRHHAIPHQIILSKVDKFLVKQLKQIKTGVTPANIERLQLLLQGIKPIVQPDPRASEGPGSLGEILTCSAEARIGPGRALGIDAVRWSILSAAGIDGSLQGGRLAVPPPAETPAILS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W6R802</accession>
    <name>W6R802_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S08g000038</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792022">
        <property type="protein sequence ID" value="CDM37987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6R802"/>
    <dbReference type="OMA" id="RWHAVWE"/>
    <dbReference type="OrthoDB" id="4664297at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2970">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM37987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="158" mass="17148" checksum="FCF51CCB98FA765B" modified="2014-04-16" version="1">MSNLSLQVTVALQAPISEAQDSFALPIKVSVHNAADTPVTILRWGSPLDPQAGVLGVFQICDTTAQRKLPIPTIMVSRKLPASEDDLVEIQARHSLDVTVNLPIPGLEKGHEYSVRAQGTWHAVWPTELSNVTTSQLRDNEGANRGDFLSNESSVNIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>W6PQQ6</accession>
    <name>W6PQQ6_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cytoplasmic tRNA 2-thiolation protein 1</fullName>
            <ecNumber evidence="6">2.7.7.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Cytoplasmic tRNA adenylyltransferase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 11" type="primary">NCS6</name>
        <name evidence="6" type="synonym">CTU1</name>
        <name evidence="11" type="ORF">PROQFM164_S01g000337</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TtcA family. CTU1/NCS6/ATPBD3 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.-" evidence="6"/>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PQQ6"/>
    <dbReference type="STRING" id="1365484.W6PQQ6"/>
    <dbReference type="OMA" id="MGKCERC"/>
    <dbReference type="OrthoDB" id="198857at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002144">
        <property type="term" value="C:cytosolic tRNA wobble base thiouridylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032447">
        <property type="term" value="P:protein urmylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002143">
        <property type="term" value="P:tRNA wobble position uridine thiolation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01713">
        <property type="entry name" value="CTU1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03053">
        <property type="entry name" value="CTU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056369">
        <property type="entry name" value="CTU1-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032442">
        <property type="entry name" value="CTU1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000541">
        <property type="entry name" value="Ncs6/Tuc1/Ctu1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011063">
        <property type="entry name" value="TilS/TtcA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035107">
        <property type="entry name" value="tRNA_thiolation_TtcA_Ctu1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11807">
        <property type="entry name" value="ATPASES OF THE PP SUPERFAMILY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11807:SF12">
        <property type="entry name" value="CYTOPLASMIC TRNA 2-THIOLATION PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01171">
        <property type="entry name" value="ATP_bind_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16503">
        <property type="entry name" value="zn-ribbon_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004976">
        <property type="entry name" value="ATPase_YdaO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 6" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="2 6" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal" evidence="9">
        <location>
            <begin position="54"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="Cytoplasmic tRNA 2-thiolation protein 1 C-terminal" evidence="10">
        <location>
            <begin position="353"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="282"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="57"/>
            <end position="59"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR004976-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF16503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDM26528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="411" mass="45306" checksum="BB5039C6B677DE9E" modified="2014-04-16" version="1">MAPTACFNCKEARAVIIRPKNRHKLCRACFIDIFETEVHETIIGTNLFFPGERVAIGASGGKDSTVLAAVLKTLNERYNYGLDLCLLSIDEGIRGYRDDSLETVKRNAVQYEMPLDILGYSELYGWTMDQVVEQVGKKGNCTYCGVFRRQALDRGAARLGIKHVVTGHNADDVAETVMMNLLRGDLPRLSRGTSIVTSSDASDIKRSKPLKYAYEKEIVLYAHHRQLDYFTTECIYSPEAFRGSARTLIKDLEKIRPSSILDIVKSGEDMAALVPVEVRGVGKSKQGEEESAGGCGSQNGRTSGGEMAAMEKELAENDTAESLETEIKIPNGSRVKANRGPTGKAVKVQTIKHCERCNYISSQRICKACTLLDGLNRNRPKTAIEVGVGMEDEESSSTLMRQMERAKLSAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2024-10-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>W6PR58</accession>
    <name>W6PR58_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S01g000040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PR58"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM26231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="62" mass="7101" checksum="AF52F014570EBFA1" modified="2014-04-16" version="1">MLSRSTLFIERSFDSLGFDLDVTCISFVFPGHKIITYGKVTVDLHTHQAYVVVVMTDRFSMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W6PRD8</accession>
    <name>W6PRD8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lipase, class 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S01g000110</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PRD8"/>
    <dbReference type="STRING" id="1365484.W6PRD8"/>
    <dbReference type="OMA" id="DYSCKPS"/>
    <dbReference type="OrthoDB" id="9974421at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016298">
        <property type="term" value="F:lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002918">
        <property type="entry name" value="Lipase_EstA/Esterase_EstB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32015">
        <property type="entry name" value="FASTING INDUCED LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32015:SF1">
        <property type="entry name" value="LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004879728" evidence="1">
        <location>
            <begin position="20"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="32"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM26301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="274" mass="29455" checksum="40D6C5F42D3001D6" modified="2014-04-16" version="1">MPSLTKLALSALATTTVVATGINDFSCQSSYNPVVLLHGLGATYYEDLNYMQYWLQTQGFCTYAQTYGAYDGFPLLGGLKAINESAPEIAAYIKEVVQKTGKSKVDLVGHSEGAFQSLYVPKFEGVAHLVDKIASIAPPTHATTFASIYNLAYTFGNQSREVVAEVLNTVGCPACNDLGPDGPAINRLNDGTPIAQPGNSVTIIASKYDELVTPPSTSFVHEEGVTNRWIQDTCPLDPVGHIGEAYDLNVWHLVKNVLTSTDEKFLCLLGSPGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W6PRF1</accession>
    <name>W6PRF1_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">glucan endo-1,6-beta-glucosidase</fullName>
            <ecNumber evidence="13">3.2.1.75</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Beta-1,6-glucanase B</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Endo-1,6-beta-D-glucanase B</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Endo-1,6-beta-glucanase B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">exgB</name>
        <name evidence="20" type="ORF">PROQFM164_S01g000125</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Beta-glucanases participate in the metabolism of beta-glucan, the main structural component of the cell wall. Acts on lutean, pustulan and 1,6-oligo-beta-D-glucosides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>Random hydrolysis of (1-&gt;6)-linkages in (1-&gt;6)-beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.75"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 17">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.75" evidence="13"/>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PRF1"/>
    <dbReference type="STRING" id="1365484.W6PRF1"/>
    <dbReference type="OMA" id="YEKQAGW"/>
    <dbReference type="OrthoDB" id="1887033at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046557">
        <property type="term" value="F:glucan endo-1,6-beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004338">
        <property type="term" value="F:glucan exo-1,3-beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000269">
        <property type="entry name" value="Probable glucan endo-1,6-beta-glucosidase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050386">
        <property type="entry name" value="Glycosyl_hydrolase_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297">
        <property type="entry name" value="GLUCAN ENDO-1,6-BETA-GLUCOSIDASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297:SF39">
        <property type="entry name" value="GLUCAN ENDO-1,6-BETA-GLUCOSIDASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 17" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 18" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004879729" description="glucan endo-1,6-beta-glucosidase" evidence="18">
        <location>
            <begin position="23"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="19">
        <location>
            <begin position="87"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00036633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00041472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00042025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00043257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CDM26316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="403" mass="45480" checksum="2ADD19B03365FE30" modified="2014-04-16" version="1">MGVISKFAAVTTLTTLATLTNAWLPEENKSITAKDGTNLFKSSNGKIRGVNLGSQFVFEPWIAESEWSGMGCGGKNSEFDCVSSLGQDAANTAFANHWASWTTQDDINEMVSYGLNTIRVPVGYWLREDIVDADSEHFPQGGLDQLKKLCGWASDSGLYIIIDLHGAPGAQEAENAFTGQYASEPGFYTDYNYERALKWLEWMVDLVYQTDEMRNVGMLEIVNEPVQDEASASSMRSKYYPQAVERIRAAEQKLSVDSNDYLHIQTMDKSWGSGDPNEYLDDLTYMAYDDHRYIKWDTSVSPSHDNYISTSCGDNRDSNWPNIVGEWSLSVPDDIEASSDWEPSSNTDFYGKWFAAQVHSYEKQQGWIFWTWKSQLNDYRWSYQDAVKAGVIPKDLNSVQSVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W6PRN4</accession>
    <name>W6PRN4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein kinase-like domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g000339</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PRN4"/>
    <dbReference type="STRING" id="1365484.W6PRN4"/>
    <dbReference type="OMA" id="WLWNERQ"/>
    <dbReference type="OrthoDB" id="2906425at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051035">
        <property type="entry name" value="Mito_inheritance_9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36091">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36091:SF2">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="62"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM26530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="516" mass="58437" checksum="9F85DF2DF61D2D9E" modified="2014-04-16" version="1">MNETESITDSMHGLEALNRFTSGRWLWNERQQLACRYVKFDHSTLLKVAASAVGSKACTHVLKISEGQYNKLFQLTIDDRRDIIAKLPNPNAGRPHFTTASEVATMDFLRNVLNLPVPRVYAWSSRAPENPLGAEYIIMEKQSGVVLNDLVDIERRLAATKFSKFGSLYYKDDLPDNSDSTSPLYLDSTGSEVRSKTFAIGPTNHRSFFDFGRGELDIERGPWSTVIGFMMAIAQREIATAKAGLRYPLMPEGLFSGPGQYQPSLSKKLPSLQNYLKVAPHVLPENKATHASVLWHGDLHAQNIFVDPADPSRIVELSTGSPLAHVRFLRRFGEGRFPTVDSMDLDEQRKAKALHRAQTLHNLYIVRCLQLNETVFQAIQDQNTLRHQVIVVPGLVLMDYQPLLNSLLRDVEKEWAHIIGAGRDGRSPGTPFPLQFSDEEIQQQEQGGELWAQGVELMNAFVDDTGCFKHWGGRVSDVDYEKSRRELDEGVKRFLDREARNDEERREWLKALLFVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W6PRV4</accession>
    <name>W6PRV4_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PROQFM164_S01g000414</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PRV4"/>
    <dbReference type="STRING" id="1365484.W6PRV4"/>
    <dbReference type="ESTHER" id="penro-w6prv4">
        <property type="family name" value="Fungal_carboxylesterase_lipase"/>
    </dbReference>
    <dbReference type="OMA" id="NDHADVP"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005151051" description="Carboxylic ester hydrolase" evidence="3">
        <location>
            <begin position="18"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="21"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDM26605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="540" mass="58166" checksum="A9775C4BD871C45C" modified="2014-04-16" version="1">MLTFLSILLATPAFAAAAVFPVIQSNYGPVKGAASPFRDGVTVYKGIPYAAPPTGSKRWTPPTKPDSWTETLNATEFGPQCAQPYSDAGIFSSGKNSTSEDCLTLNIWTPTYNTTSATEIKNKNLPVYVWIFGGRFEGGSGDVITYDGTGLASKDIIVVTLNYRLGAFGFLAHPDLSTESGHNSSGNYGILDQQFALRWVQDNIAHFGGNASQVTVGGQSAGSASALDMMWSPLSRGLIHGVISESGARGPHDPATGGVATSYNTKAVAEAFGVTFLKTMNVSSIAELRKLPMADLIGEGQLMEDDYFEGTAFSDLLSGPPRWRPVIDGYVLRHGYGESLELNAHADVPIMTGNNKNENDGGASTVSTYKTLWTKVFGNYSAEFFSLYPAKTDTQASANSDAVLLDMARVGTWEWAAEWAAGGAKKDVFVYYFTSSPAEGSGGAYHGAELWYAFNNIPYSDYSNVTWNATDYKIESVISEYWANFIRTGNPNGDGLVHFPASSSNYSAMQLGDSFGAVPIAASKKRIAFLRRWMSTLHEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W6PS67</accession>
    <name>W6PS67_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major facilitator superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PROQFM164_S01g000405</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PS67"/>
    <dbReference type="STRING" id="1365484.W6PS67"/>
    <dbReference type="OMA" id="FILSMWY"/>
    <dbReference type="OrthoDB" id="2962993at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000057">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF36">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G08340)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="152"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="221"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="297"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="338"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="361"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="392"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="424"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="453"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="60"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM26596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="518" mass="57447" checksum="D31A83B4CEC8FFE1" modified="2014-04-16" version="1">MEKSTDFSPPSSLTDTERKGEVVTVTDGNSALEYERFLHLDNVFNGPAKKKLIRKLDARLLPTLSFLYLMCSLDKSNAGNAKLFGLLEDIGMNGTQYNLALMYFFFTYGLFEPVSNIMLRRVGPKIWFPFIVCAWGLITTLTSQAHSYGSFIVIRLMLGITEAGLYPGAYFILSMWYTPKEIGTRMAIFYGANTTAGAFGGVIAYGVGYLDGHHGWRAWRWLFLIEGCITIFAGLACLVCLPAFPHQYRAGKGTKWLTDEELEYASLRVKYANGPVTSTYEFRWSDVLSAAKDRKTYFMMMLFWWGGSVPTYSLSYTLPTMVKNLGYTAVRAQVMTTPPYIFATCVCVAVGYISDLKQRRYFCIMGAYSLGLIGIIILWITVHHPSIPGVSYFAIFLAAAGYSAQAPIVGAWTSSNITNPSKRAAAIGLLMLFGSVGGGSIGSNIYISSEAPVYPLGFGFSVGATVLGAMIPATVHWFLMRKENKRRDGLDVDEIERTYTPEQLGEMGEDSPLFRFVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W6PS79</accession>
    <name>W6PS79_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HAD-like domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S01g000420</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PS79"/>
    <dbReference type="STRING" id="1365484.W6PS79"/>
    <dbReference type="OMA" id="CTDVAIE"/>
    <dbReference type="OrthoDB" id="158672at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043682">
        <property type="term" value="F:P-type divalent copper transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055070">
        <property type="term" value="P:copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43520">
        <property type="entry name" value="ATP7, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43520:SF32">
        <property type="entry name" value="COPPER RESISTANCE P-TYPE ATPASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-1278">Translocase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM26611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="120" mass="12809" checksum="1EB54843A6BA333F" modified="2014-04-16" version="1">MADVGVAIGSGSDIAISSADFILVSSQLDSLLTLIDLSRIVFKRIKFNFAWALVYNLIALPVAAGVLYPVKTSGGHIRLDPVWASLAMALSSVSVVCSSLLLRSRLPGIGYRLAEDRQCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W6PU68</accession>
    <name>W6PU68_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glucosamine 6-phosphate N-acetyltransferase</fullName>
            <ecNumber evidence="8">2.3.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">GNA1</name>
        <name evidence="10" type="ORF">PROQFM164_S01g001105</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>D-glucosamine 6-phosphate + acetyl-CoA = N-acetyl-D-glucosamine 6-phosphate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10292"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57513"/>
            <dbReference type="ChEBI" id="CHEBI:58725"/>
            <dbReference type="EC" id="2.3.1.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; N-acetyl-alpha-D-glucosamine 1-phosphate from alpha-D-glucosamine 6-phosphate (route I): step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the acetyltransferase family. GNA1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.4" evidence="8"/>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PU68"/>
    <dbReference type="STRING" id="1365484.W6PU68"/>
    <dbReference type="OMA" id="NQRYDWI"/>
    <dbReference type="OrthoDB" id="10039976at2759"/>
    <dbReference type="UniPathway" id="UPA00113">
        <property type="reaction ID" value="UER00529"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004343">
        <property type="term" value="F:glucosamine 6-phosphate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000048">
        <property type="entry name" value="Glucosamine 6-phosphate N-acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039143">
        <property type="entry name" value="GNPNAT1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13355">
        <property type="entry name" value="GLUCOSAMINE 6-PHOSPHATE N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13355:SF11">
        <property type="entry name" value="GLUCOSAMINE 6-PHOSPHATE N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="9">
        <location>
            <begin position="53"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDM27296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="195" mass="21765" checksum="86D4735D7D69B5E6" modified="2014-04-16" version="1">MTAHALPSTTTSEAVKPIMSSTVTSVDETVTDGPLFPSTLISPEVISLLPTDYTIRPMRRSDYSRGYLDVLRVLTTVGEITEEAWNQRYDWITSRNDEYYMLVVCDGADRVVGTGSLIVERKFIHSLGMVGHIEDIAVEKNQQGKKLGLRIIQALDFVAAHVGCYKSILDCSEVNEGFYVKCGFKRAGLEMAHYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W6PUG4</accession>
    <name>W6PUG4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized domain, di-copper centre</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S01g001659</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PUG4"/>
    <dbReference type="STRING" id="1365484.W6PUG4"/>
    <dbReference type="OMA" id="GTHINQT"/>
    <dbReference type="OrthoDB" id="6132182at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1280.10">
        <property type="entry name" value="Di-copper center containing domain from catechol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008922">
        <property type="entry name" value="Di-copper_centre_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050316">
        <property type="entry name" value="Tyrosinase/Hemocyanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002227">
        <property type="entry name" value="Tyrosinase_Cu-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474:SF116">
        <property type="entry name" value="TYROSINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474">
        <property type="entry name" value="TYROSINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00264">
        <property type="entry name" value="Tyrosinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00092">
        <property type="entry name" value="TYROSINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48056">
        <property type="entry name" value="Di-copper centre-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00498">
        <property type="entry name" value="TYROSINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004881590" evidence="2">
        <location>
            <begin position="19"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="3">
        <location>
            <begin position="331"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM27848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="409" mass="44253" checksum="B6982F7A48AA456A" modified="2014-04-16" version="1">MVAISILTLGALFAQAWAIPTAVDSATASATPTAASTSLPIAESQLADLAGLAYNTTIDTVSSDSDITKRGTCSLSNLRIRRDWRTFSSTQKKSYISSILCLQKLPSLTPSAEVPGARSRYDDFVATHINQTLEIHFTGTFLAWHRYFIYNFEEAMRNECGYTGDYPYWNWPADAGNLETSQVFDGSDTSMSGNGATVASAGDIQLSLGDYPIIYLPTGNGGGCVTSGPFKDYTVNLGPVTLMLPGGGSQTSENPFAYNPRCLKRDLTTKIVQDYANFTAVVDLILRHDNVYDFQMNMQGVPGSGNIGVHGGGHYSMGGDPARDVFVSPGDPAFWLHHGMIDRTWWIWQNLDLHKRLNAISGTGTFLNSPASANTTLDTLINIGYAGGSDIAMRDLMSTVSGPFCYIYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>W6PUP0</accession>
    <name>W6PUP0_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">DNA-directed RNA polymerase subunit beta</fullName>
            <ecNumber evidence="15">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="primary">RET1</name>
        <name evidence="24" type="ORF">PROQFM164_S01g001292</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol III is composed of mobile elements and RPC2 is part of the core element with the central large cleft and probably a clamp element that moves to open and close the cleft.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the RNA polymerase beta chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="15"/>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PUP0"/>
    <dbReference type="STRING" id="1365484.W6PUP0"/>
    <dbReference type="OMA" id="LAYCSWC"/>
    <dbReference type="OrthoDB" id="10248617at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032549">
        <property type="term" value="F:ribonucleoside binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006386">
        <property type="term" value="P:termination of RNA polymerase III transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00653">
        <property type="entry name" value="RNA_pol_B_RPB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.270.10:FF:000006">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.270.10:FF:000011">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
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    <dbReference type="FunFam" id="3.90.1100.10:FF:000020">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.270.10">
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    <dbReference type="Gene3D" id="3.90.1800.10">
        <property type="entry name" value="RNA polymerase alpha subunit dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1110.10">
        <property type="entry name" value="RNA polymerase Rpb2, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA-dir_RNA_pol_su2"/>
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        <property type="entry name" value="DNA-dir_RNAP_su2_hyb_sf"/>
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    <dbReference type="InterPro" id="IPR007642">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
    </dbReference>
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        <property type="entry name" value="RNA_pol_Rpb2_2_sf"/>
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    <dbReference type="InterPro" id="IPR007645">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
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        <property type="entry name" value="RNA_pol_Rpb2_5"/>
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    <dbReference type="InterPro" id="IPR014724">
        <property type="entry name" value="RNA_pol_RPB2_OB-fold"/>
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    <dbReference type="NCBIfam" id="NF007175">
        <property type="entry name" value="PRK09606.1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT 2"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RNA_pol_Rpb2_4"/>
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        <property type="entry name" value="RNA_pol_Rpb2_5"/>
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        <property type="entry name" value="RNA_pol_Rpb2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RNA_pol_Rpb2_7"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01166">
        <property type="entry name" value="RNA_POL_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 15 24" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 15" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 15" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RNA polymerase beta subunit protrusion" evidence="20">
        <location>
            <begin position="100"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="19">
        <location>
            <begin position="253"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="21">
        <location>
            <begin position="511"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="22">
        <location>
            <begin position="612"/>
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    <feature type="domain" description="RNA polymerase Rpb2" evidence="23">
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            <begin position="693"/>
            <end position="726"/>
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    <feature type="domain" description="DNA-directed RNA polymerase subunit 2 hybrid-binding" evidence="17">
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            <begin position="740"/>
            <end position="1111"/>
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    <feature type="domain" description="RNA polymerase Rpb2" evidence="18">
        <location>
            <begin position="1113"/>
            <end position="1197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="22"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00006835"/>
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            <dbReference type="ARBA" id="ARBA00011206"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022771"/>
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            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00053978"/>
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    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU363031"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF04560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF04561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF04563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF04565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF04566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF04567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="CDM27481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="1208" mass="135065" checksum="C02DE2D975191D57" modified="2014-04-16" version="1">MPPRKRPQPSAASRPRRPSEAGSHSATDSTKSKRPSVSNPVPEPHQHPVPGKVEPASDFKARDPFDALLEPFYYNKGLTDPIDTARDKWNLLPAFLKVKGLVKQHLDSYNYFVEVQMKKIVESSSTIRSDVDHNFYIKFTDIYVASPRRADEQGDGGIDFESTITPQECRLRDTTYAAPILVDFEYVRGRQRVIRRAVPIGRIPIMLRSSKCVLSNKTPAQISVLNECPLDPGGYFVVNGTEKVILVQEQLSKNRIIVETDPKKDIVQASVTSSSNERKSKSYIVSKKGRLYVKHNVLNEDIPIVILLKAMGIHTDKEMMQMVTGDDSLYQDDFAINFEEAINVDVYTQQQALEWIGCRIKINRKQAAYRKTHVQEAVEAIASVIISHIEVKDMNFRPKAIYVAHMARRVLMAKSDPALVDDRDYLGNKRLELAGQMLALLFEDLFKKFCFDIKMNIDKVLNKRNRAEQFDAWTIVTMHGNHITQGMNRAISTGNWSLKRFRMERAGVTHVLSRLSYIAALGMMTRISSQFEKTRKVSGPRALQPSQFGMLCPADTPEGEACGLVKNLALMTHITTNDEEGPVRNLIFMLGVEDISSVGGQQLYARGAYTISINGTPTGLTRRPKSFLNAFRRLRRMGRVSEFVSIYINHHQRAVHVATDDGRICRPLIVVENGKSLVSVQHLEKLRDGEMEFDDFLAQGLVEYLDVNEENDSYIAIYEKDISNTHTHLEIEPFTVLGAVAGLIPYPHHNQSPRNTYQCAMGKQAIGAIASNQFQRIDSILYLMVYPQKPMVKSRTIELTKYDQLPAGQNATVAVMSYSGYDIEDALVLNKGSVDRGFGRCQVFRKYVTTLKSYPNGAKDSLKGPTYENGVPIRKHALLESDGLAAVGEMVNNGESYINKVTPRVQNSLGFPGSDIGGGDVIEAPMNYKLPDPSYIDKVMLSATEGETQLIKVLTRQTRRPEVGDKFSSRHGQKGVVGIIADQADMPFSDQGINPDIIMNPHGFPSRMTVGKMLELVAGKAGVLSGQHGYGTCFGGSPVEEMSQILIDKGFSYGGKDYLTSGITGEALPFYVFTGPIYYQKLKHMVQDKMHARAKGPTATLTRQPTEGRSRNGGLRLGEMERDCLIAYGTSQLLLERLMISSDRHEVDVCEKCGFMGYLNWCPGCKSSRSVVKMVIPYAAKLLIQELMSMNVTARLKLDDEFPEMKGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W6PUV0</accession>
    <name>W6PUV0_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="11">CBF1-interacting co-repressor CIR, N-terminal domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PROQFM164_S01g001476</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CWC25 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PUV0"/>
    <dbReference type="STRING" id="1365484.W6PUV0"/>
    <dbReference type="OMA" id="SWHPHTM"/>
    <dbReference type="OrthoDB" id="21123at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019339">
        <property type="entry name" value="CIR_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022209">
        <property type="entry name" value="CWC25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051376">
        <property type="entry name" value="CWC25_splicing_factor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16196">
        <property type="entry name" value="CELL CYCLE CONTROL PROTEIN CWF25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16196:SF0">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR CWC25 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10197">
        <property type="entry name" value="Cir_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12542">
        <property type="entry name" value="CWC25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01083">
        <property type="entry name" value="Cir_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="CBF1-interacting co-repressor CIR N-terminal" evidence="10">
        <location>
            <begin position="10"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="104"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="158"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="27"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="104"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="180"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="193"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="203"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="231"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="304"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="349"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="373"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDM27665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="434" mass="51846" checksum="9D20BF9D06B70FB2" modified="2014-04-16" version="1">MGGDLNLKKSWHPGLIKNQERVWLEEKRALDERKKIAQLQREREEERQMEEIQRLQEASGKAKQHSRVDWMYQAPSGETGHYSEEMEGYLLGKRRIDGVLLKKDPDTKKLEKGSEVVGNGSAAGPSIVSARDTMSKVMADPLLEVKKREQAAYEAMVKETLRRKEREKERGDRDRGKDRDRRHRTHDSKRRRYSDDAGDERRERHHRRSSPRRHRSRSPASPDRSSRRHRSDRDRERRDDEYRPDNRDRRSDENRSRRDDRDRGRDRRDYHDKRDSHSSRHQDREDRGGRDRSPSRNSRSPRPSSDRKERPAADEDRSRDFPRREYNNRRDSARGAMGPPSTRTPTNKPDPKELEEERRRKLAEMQYNATEIESERRRRLAEISAKEEEQREADDRQRSDRGRFMSDVNKRVQEDTLDERIRRSRGGLSKMEKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W6PVK1</accession>
    <name>W6PVK1_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g001746</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PVK1"/>
    <dbReference type="OMA" id="EFLNPCD"/>
    <dbReference type="OrthoDB" id="3946700at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="401"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="248"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="402"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM27935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="423" mass="46759" checksum="D3B8E82E1DD65ED0" modified="2014-04-16" version="1">MGIPMWREPPKSEAFKSTSEKDTSATARSSIRRAPSRNTSSRVRRADILASFHSQIIDELRRGAVEPRRVPRFSFIAPNGNVDNAVAVEPADRVALSSWARSEAASTNRQTDTTVANQLFRNHRDQALAELFGRMDGQPGNTNAGPSLTPNFAPAIAYHTSASSTPSDSGLRLPPMRERYNSDRTSNTSFPPEIPEYRSNNTQTRPNRDPVVDGLGDRQRSPSPDEERESVVWETLLSTIAPDETLPSTNTSFTSTSAAVPDISRNPRPRSSVNLTQPMTAEAARTHFGLDPYPDQLNPCDFSSDDEEPPSTLQEFIGRRRAGRYPDQHSTMSNHPPVPIPTIIPASVLALSDARRQNSSLSDRHQNDDLHHMQVILDRLARREDIPDDWWAAAGLARTLDRGSSASMDSTDTEGASRTNRDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W6PW98</accession>
    <name>W6PW98_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Glycoside hydrolase, family 61</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PROQFM164_S01g002329</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PW98"/>
    <dbReference type="STRING" id="1365484.W6PW98"/>
    <dbReference type="OMA" id="INYMANC"/>
    <dbReference type="OrthoDB" id="4849160at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21175">
        <property type="entry name" value="LPMO_AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049892">
        <property type="entry name" value="AA9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005103">
        <property type="entry name" value="AA9_LPMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353:SF34">
        <property type="entry name" value="ENDO-BETA-1,4-GLUCANASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03443">
        <property type="entry name" value="AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004879793" evidence="6">
        <location>
            <begin position="20"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="Auxiliary Activity family 9 catalytic" evidence="7">
        <location>
            <begin position="20"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="265"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="328"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM28518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="404" mass="40436" checksum="986864292D067955" modified="2014-04-16" version="1">MSVSKIAGLLLSSAAMVAGHGFVSGAVVDGTYHGGFIVNTYNYMTEVPANIGWSEKATDLGYIDGSGYTGSDIICHKEATPGAISAEVKAGGSVELQWTDWPESHHGPVITYMANCNGDCSVVDKTTLKFFKIAEAGLIDDTNVPGTWASDQLIAANNSATVTIPSTIAAGNYVLRHEIIALHSAGDANGAQNYPQCINLKVTGGGSDSPDGVLGTALYTPTDPGILISIYSALESYVIPGPALYTGASSGSSSTSSTTAAATTEATTASATVSTTAAPTVATTSASTTASTADSITITTTAGGLSAQSSAAVLESSATSTVTAEATATAAPTAAATTSTSSTSSGSSSSSSTSSSGSSSTSSTSTSNSSYLSSLSAEKLLEVIRSTLKWLVSDKKVHARALAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W6PWX4</accession>
    <name>W6PWX4_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">alcohol dehydrogenase (NADP(+))</fullName>
            <ecNumber evidence="9">1.1.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">ADH7</name>
        <name evidence="13" type="ORF">PROQFM164_S01g002266</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a primary alcohol + NADP(+) = an aldehyde + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15937"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15734"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:15938"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="10">
            <dbReference type="Rhea" id="RHEA:15939"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.2" evidence="9"/>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PWX4"/>
    <dbReference type="STRING" id="1365484.W6PWX4"/>
    <dbReference type="OMA" id="CRGRNGD"/>
    <dbReference type="OrthoDB" id="1879366at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008106">
        <property type="term" value="F:alcohol dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006066">
        <property type="term" value="P:alcohol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05283">
        <property type="entry name" value="CAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000158">
        <property type="entry name" value="Zinc-binding alcohol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047109">
        <property type="entry name" value="CAD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42683">
        <property type="entry name" value="ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="12">
        <location>
            <begin position="17"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00050997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDM28455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="358" mass="37975" checksum="2242351F0011584D" modified="2014-04-16" version="1">MTDYKFEGWCGLGPEAGKGKMVWQEFEPKPWEETDVDIKVTHCGICGSDLHTLRSGWGPTKYPCCVGHEVVGTAVRVGTQVKNGIKVGDRVGVGAQSGACGNKDGDCEACAASLEQFCNKMVGTYNGVYANGGKSYGGYATYNRSSSHFVIKIPDAISSADAAPMLCGGITTYSPLKQNGCGPGKTVGVVGIGGLGHFAILFAKALGADRVVAISRKSDKKADALKLGADDFIATSEEEDWVTRHGQSLDLIISTASSSKMPITGYCSLLRFRGTFIQLGAPEDGGLEIPFFALIGKGIKLGGSLIGSPDEIREMLDLAAAKGVKPWIQERPMKDANQAIVDMDNGDARYRYVLVNNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W6PXB8</accession>
    <name>W6PXB8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha/beta hydrolase fold-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S01g002674</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PXB8"/>
    <dbReference type="STRING" id="1365484.W6PXB8"/>
    <dbReference type="OMA" id="EKYFDYT"/>
    <dbReference type="OrthoDB" id="408373at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050266">
        <property type="entry name" value="AB_hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002410">
        <property type="entry name" value="Peptidase_S33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798:SF33">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G14860)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798">
        <property type="entry name" value="MONOACYLGLYCEROL LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00793">
        <property type="entry name" value="PROAMNOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="23"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM28863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="280" mass="31488" checksum="EB9EEF735408B1F7" modified="2014-04-16" version="1">MVEYVSINGAQLAYRLIGPADAPLIITLHGGRGFGDHKSDYKAYSSLSSSYRVLSFDFRGHGQSSRTEPFTFHQVVEDIEGLRRHFLGPNQPCIICGGSFGGFLAQQYAITYPSQVSHLILRGTAPSHHHEETAIRTLEQRASRAPNLSINFLKDKIFGQFESDLEFRLVMYAAAPLYSENFDPDLALKHNIETVFYAKSHNDLYSKQEKFFDYRDQLPLITAKALVIVGERDWICPPEQSKDIASRIPGAQLKVIENANHSVHLEKNAEVIGLIEKHLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W6PY46</accession>
    <name>W6PY46_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Replication factor A protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S01g002711</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the replication factor A protein 3 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PY46"/>
    <dbReference type="STRING" id="1365484.W6PY46"/>
    <dbReference type="OMA" id="HRYKEIF"/>
    <dbReference type="OrthoDB" id="188186at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005662">
        <property type="term" value="C:DNA replication factor A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04479">
        <property type="entry name" value="RPA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000271">
        <property type="entry name" value="Similar to ssDNA binding protein Ssb3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013970">
        <property type="entry name" value="Rfa2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15114:SF1">
        <property type="entry name" value="REPLICATION PROTEIN A 14 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15114">
        <property type="entry name" value="REPLICATION PROTEIN A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08661">
        <property type="entry name" value="Rep_fac-A_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM28900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="118" mass="12687" checksum="CE39CBAD701461F0" modified="2014-04-16" version="1">MSLQTPRILPSHLHAFHPSSTSSNTVRILGTVTALHGNTGTLTCGTNGDVTLILKSDARLQVGKLVEIVGKVADLEGGQGYGIRVLGSTEWGDPADCDYKIYENVVNATHKFKSIFYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q0A3</accession>
    <name>W6Q0A3_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase M20</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S01g001455</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20A family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q0A3"/>
    <dbReference type="STRING" id="1365484.W6Q0A3"/>
    <dbReference type="OMA" id="CLQAYPG"/>
    <dbReference type="OrthoDB" id="4676at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016813">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03884">
        <property type="entry name" value="M20_bAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010158">
        <property type="entry name" value="Amidase_Cbmase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01879">
        <property type="entry name" value="hydantase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32494:SF5">
        <property type="entry name" value="ALLANTOATE AMIDOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32494">
        <property type="entry name" value="ALLANTOATE DEIMINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001235">
        <property type="entry name" value="Amidase_carbamoylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="Bacterial exopeptidase dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM27644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="449" mass="48869" checksum="4B8BAFD2AF1E257D" modified="2014-04-16" version="1">MASSQLSPFKVNQTRLLESLHTSCQHGSAHPYGNDSTETGMARLSLTDSDKDVREWFIESAKAIGCHTYVDQMGNLFAIRPGKNKDAPPIMMGSHLDTQPTGGRYDGILGVVAGLEVLKVLEENSFETEGSIGVVDWTNEEGARFPVMAISAAVWAEAIPLTTAWNLKEISAGDNTTRKTMKEELNRIGYVGETPASFKANPFAAHFELHIEQGPILEDEGRKIGVVQGVQAFKWFDITVSGRDSHAGTTPLYARKDAMLCAAKMITTANSIAKKANGLATTGIIHSEPGTVNTVAQTINFSLDLRHTFDEDLENMIADCMAEFKRIATDDSERGCTVEWKELVDSPAVHFDKDCISMVEESAKTVLADVPDPISGGKQWRDMISGAGHDSCYTNRRCPTSMIFTPTRNGISHNPVEYCSPEDCALGANVLLGAVLGYDKLRAKRGDFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q0H7</accession>
    <name>W6Q0H7_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="4">T-complex 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S02g000192</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TCP11 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q0H7"/>
    <dbReference type="STRING" id="1365484.W6Q0H7"/>
    <dbReference type="OMA" id="FHAWKTH"/>
    <dbReference type="OrthoDB" id="276323at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010737">
        <property type="term" value="P:protein kinase A signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008862">
        <property type="entry name" value="Tcp11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12832:SF18">
        <property type="entry name" value="IQ CALMODULIN-BINDING MOTIF DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G08920)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12832">
        <property type="entry name" value="TESTIS-SPECIFIC PROTEIN PBS13 T-COMPLEX 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05794">
        <property type="entry name" value="Tcp11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="52"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="201"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="454"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="154"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="61"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="215"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="454"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="475"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM30043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="978" mass="108953" checksum="B9AF7CF279B56D86" modified="2014-04-16" version="1">MIRRNSDIEIQLPDAGPTPLSPDSVSDLDVEMFSEELTLPLSLPPHIAARFARKSSKARRSSTASSRRSSVSSLHSHHSNASSNGSLSADHIAQHLRRTSILESRKARLADRALHAEKVRLRAALAKAATRNFQFEERALAAQQARERLLADITAKCEGQVRRAKKKAEDQREKKAAEQARMRLEMAEKLAEAEKRRTLYQKTHRRQRTSSLPVTEEKKMSREVTKSVQQDAAARKIQRVWKTHNAKMVMQQFQSLNLSVDRVRDMTFEEVGALLSDSNLLDTMTKVLRLCGLQDMEGGALGERGAVRTFLSSYLIVTHPQEVLSSNGDQEQDLIAKARELLIAFHQVTALLSSGCCSPSVITADLQTLCESHNVFFSAFHAWKSHDSSVLIEIMVAQFVELELIWQTVKNDKAGGAAEDYRLGIRQNQVLLLARLKRLAGPERHMELIRNSLKKAKREKKKAASKQAIPRSAETAPPTTVTQSVTSPLSESFNNIDAAVFQELDKQRTSPHERFTRILTPLPENRELVHELLINKEFKIEEAPYTEPRRQIMKQMCDTMRRGVEAGHSTNWTVAMATVIQDRLLRSLQQGNSLYVIISEVLDPKLVQGQCEAGTFSYDNFFGFMNNILPRLCAPYRDPVVKAYIEDTSGDAIDRLSRLMSIIDLLSLDQTNFMIQLAAPQLIEEAPGYERRAFDRDVTDGTVNLGKVRRFWRIHRNIIVDEMKKRDPEGIQGEPRPSPTRVYAQGLADTVLSNALVSEDIIPETLSLDRQRLERLHARAFQIVATASILLTAKNLLKRDARSQWKPEADRILSLDFNEISAERVQSILESTHPMPPAASAQLAATIKRVLGPVATACLAAAPQLAVVTSESSASDASVSSAESHGATTSAASFSDPVTKLILSRLRSHVLSRLSASSASERIRATTTASQMLAGAGMPEFVNEVGKLVEELEKVREVDWLCHGSVYEGLYEEGAPAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q0M5</accession>
    <name>W6Q0M5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FAD-binding, type 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PROQFM164_S01g003328</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q0M5"/>
    <dbReference type="STRING" id="1365484.W6Q0M5"/>
    <dbReference type="OMA" id="STNCWLQ"/>
    <dbReference type="OrthoDB" id="2151789at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF54">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004879297" evidence="5">
        <location>
            <begin position="18"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="6">
        <location>
            <begin position="91"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM29516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="521" mass="55861" checksum="774D421F1780D89A" modified="2014-04-16" version="1">MQLLGFLIGALAAAAQATSTSNVTKFTSFAQNLGLSAANTRALAARYAKADDSVAILNVACLTAQGVLGAANVDTSPLNQTIVDVNWSESCFAEPHCIIQPEVAQDVSTAVKVIGFFQVKFAVRSGGHSPNPGWSSIGSQGILIDLSKLSSVSLSSDGKVASVGPGLRWGEVTEALNPEKAVVLGGRLPSVGVGGLILGGGYHHLSTRYGLAADNVHNFEVVLSNGTIVDANAEQNSDLFRALKGGGPNFGIVSRYDLNTVPVYEVWAEMRYYSTDQAPAVLDAFTEWQLNGASDVKSVVAIDISLTSIVIGLVYSEPAVKPSAFAPFYDLEPLSIPVPGMNTTFVVIDELLASAFPTAKARHDYRGCSTRINANLTRDVYDYWVEKAQAAYQATGVNQTFALQYVGENLIQKGIENGGNALNIPSGPQQWWTTIVDWENEADDEAARSVSIETTKYWKKLAKERGLDVSLTYMNDASRDQNPLESYGATSLKQLKATSKKYDPTQMLQRLQNNGFLLSKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2024-10-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q1Z2</accession>
    <name>W6Q1Z2_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S02g000718</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q1Z2"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM30568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="49" mass="5174" checksum="3D92E538B8F0D271" modified="2014-04-16" version="1">MAVCRADWIDTSRTNALSLASRVGNLYIIYGGSISAGISASEPQVSRSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q298</accession>
    <name>W6Q298_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major facilitator superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PROQFM164_S02g000265</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q298"/>
    <dbReference type="OMA" id="IWQMILF"/>
    <dbReference type="OrthoDB" id="419616at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17330">
        <property type="entry name" value="MFS_SLC46_TetA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001958">
        <property type="entry name" value="Tet-R_TetA/multi-R_MdtG-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504:SF3">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01035">
        <property type="entry name" value="TCRTETA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="66"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="136"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="193"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="235"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="303"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="338"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="371"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="404"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="441"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="478"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="65"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="32"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM30116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="512" mass="54564" checksum="567AE52E98090196" modified="2014-04-16" version="1">MVAITQTDSQPDAVDEEANYVNETTALLGTSKTKYADARTSDTLDSSPGPDSDSDDEEEPLPKLQILLLCYARVVEPLAFFSIFPYVSQMVQDNGGVADTDVGFYSGLIESMFSLTQAIVMIFWGRAADHLGRKPVLVSSLFGVTVATGLFGLAKTIPQMIMFRCLAGVFAGTIVTIRTMVAEHSTPSTQARAFSWFAFSGNLGIFLGPLLGGALADPVRQYPGVFGNIGFFEKYPYVLSSFVVALIGATAAVSSACFVEETLKKEPVVVDRDGGEATSDALTESGDLSTLQLLKSPGVGMVLYTYGHIMVLAFAYTAIIPVFWFTPVNLGGYDFTPLQISLMMGLNGASQAAWLLLVFPPLQRKIGSNGVIRLCALAYPLFFLLCPLGNVLLRVGTDGSVKAFWILLPLGLAIGCGVSMSFTAIQLVLNDVSPSPRVLGTLNALALTGSSALRAFCPALFTSLFALGARTQLAGGHAIWILLLMLASGLSVTAKYLPEPRATGKHRNSQAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q2F5</accession>
    <name>W6Q2F5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Berberine/berberine-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PROQFM164_S02g000315</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q2F5"/>
    <dbReference type="STRING" id="1365484.W6Q2F5"/>
    <dbReference type="OMA" id="GLFNCWK"/>
    <dbReference type="OrthoDB" id="9983560at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050432">
        <property type="entry name" value="FAD-linked_Oxidoreductases_BP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13878:SF91">
        <property type="entry name" value="FAD BINDING DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G12070)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13878">
        <property type="entry name" value="GULONOLACTONE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004881239" evidence="3">
        <location>
            <begin position="28"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="4">
        <location>
            <begin position="130"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDM30166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="599" mass="66030" checksum="778B367863C70FA4" modified="2014-04-16" version="1">MVQLLFAPLVNAASVLAVFGLISTTSATSPGYNCKAGQPCWPSNKEWESFNSSLSGNLHRTVPFAASCYYSSQYYDPSACDIVKSNYSTNQARTDVYGAATGLNWEGCRSQTCALNALNPAEVISDNCYLGRLSSLYVDARKPSHVVTAVKFARKHHLRITIKNTGHDYFGRSTSPDTLAIWTHNMNNMKYHKNFTASNCPASNGQHIAEIGSGAQATDVYTYFTKFNMDVTGGNEGSVGLAGGFGQGGGHGVFGPKYGLMVDNAVEFEVVTADGKLRVINKCNDPELFWAMRGGGGGSFGILTSYRFQLHPAVKINVYQFEGSFTTHGNETANYAALKQVLTQHATYQPTWSHNNISGHAYYWPTKAEIYLVLPSNNETALKTLTRGFSSFLANQTNIQVTKSNYTTYPKYTEFLQITDGIAAEYTPGGIFEAVAGRLIPRSLFESKRKVADLVDAVLQGVRLSNKLLPAGDSLTQIIMTTPVNHQNGNTTSANPAWRPALWHTLMTGGWTSELGVQNETNLLEAWLDTVEPLKRLTPGGGCYLNEGHYLEPKWQETFFGSNYPELLRIKKKYDPTHFFDCWKCVGWKGPSDAYYCYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q2H8</accession>
    <name>W6Q2H8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Protein kinase-like domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PROQFM164_S01g002220</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q2H8"/>
    <dbReference type="STRING" id="1365484.W6Q2H8"/>
    <dbReference type="OMA" id="HHRGAKN"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43289">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 20-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43289:SF6">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE NEKL-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="119"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="328"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="407"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="630"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="366"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="407"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="444"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM28409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="740" mass="81902" checksum="BDE679C0AD7BFC06" modified="2014-04-16" version="1">MSQNETSLWWPEERIKSTLDKKYIISRLRPENIPRLFELPDWGEGLTSETYMEWILTKAGRVFMILDAIGIPDRIFALVDESCDDDDLPIAEHSVDLLHLSPDGDDVALETSFFHAQWRFLVRGIAEGEHVVYTENEGVPVEAVRTNTSSGIHGRDDTVDRVVLAGPVCRVYMRTQVQVGGAPHFFSSDEVLAEIRSLKRLSHEHLVSVYASYLKDDSVSVLFTGATADRNLYRFLTDEPLAFKRLEKEQRRQILITWPHCLASAVCWLHARGYAHGAIRPSNIFVDADYHICLGQFQALDSLLTPPHVNDLEAYNYSAPERWTRPTAPVILKPVQPAKTLLPSGGRTKRRQRPTRLTLPPLNESRAASPNHTRPNSSSSKGTAIRIGRSGSPSRFSFAFSSSSSSSEVSSAASSTHTDATATSPQATPRHRISSFWARRTKNTPSIMSTSTSSSSNTSSLTSPTSLRHSTSTPSLPHSHNHNHTHPPNPNSPADIFSLAATTLDILTILHKRTLASFSGHRSARNRSAGRGGGIADASFHLERNAVQIQSWISRLEGDALKRCRRDRRSDRAFWAVPRMLLVVRAMLDLEGARRPLAGRVRKGFADAITKKGGGSGDGLLVLHCVKEKREEGGHRETHRDESHKEGNNNRKLEVVREVGESASVVSSAPVESGSVSVAESVSEFDFGFGHAGSESESESNFEGDFVDFDRKEDVSAMPELYLPELEMNITGIEGMSFKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q396</accession>
    <name>W6Q396_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="4">EF-hand-like domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S02g000900</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q396"/>
    <dbReference type="STRING" id="1365484.W6Q396"/>
    <dbReference type="OMA" id="ADWMTKH"/>
    <dbReference type="OrthoDB" id="289247at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005793">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040250">
        <property type="entry name" value="Nucleobindin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19237">
        <property type="entry name" value="NUCLEOBINDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19237:SF20">
        <property type="entry name" value="NUCLEOBINDIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004881254" evidence="2">
        <location>
            <begin position="22"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="89"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM30750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="202" mass="22861" checksum="5C7FF89501F667D6" modified="2014-04-16" version="1">MVNKLFGLAAGLLALSGLANAHGSHSNDEAPSDDWATRHMIEEHHIESFDPSSFFILHDYDSSGTWSQDEVRKTYGLNDESNAGVSEEKKQDAVRAVFEIFDTGRTGFINREDWLAGLAAGNRLPDLGYGPGHHGDLEYEYEIHHFEKFHGDDTTEEDLTHPEDIEHFRKHDEEEDAAIALDKLEQIQVVVGNIPQKFRRNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q3A1</accession>
    <name>W6Q3A1_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">Adenylyl-sulfate kinase</fullName>
            <ecNumber evidence="4 11">2.7.1.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PROQFM164_S02g000600</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the synthesis of activated sulfate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>adenosine 5'-phosphosulfate + ATP = 3'-phosphoadenylyl sulfate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24152"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58243"/>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.25"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the APS kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.25" evidence="4 11"/>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q3A1"/>
    <dbReference type="STRING" id="1365484.W6Q3A1"/>
    <dbReference type="OMA" id="HENTVEE"/>
    <dbReference type="OrthoDB" id="506431at2759"/>
    <dbReference type="UniPathway" id="UPA00140">
        <property type="reaction ID" value="UER00205"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004020">
        <property type="term" value="F:adenylylsulfate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019344">
        <property type="term" value="P:cysteine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070814">
        <property type="term" value="P:hydrogen sulfide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000103">
        <property type="term" value="P:sulfate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02027">
        <property type="entry name" value="APSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000212">
        <property type="entry name" value="Adenylyl-sulfate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00065">
        <property type="entry name" value="Adenylyl_sulf_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002891">
        <property type="entry name" value="APS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059117">
        <property type="entry name" value="APS_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00455">
        <property type="entry name" value="apsK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003013">
        <property type="entry name" value="PRK03846.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11055">
        <property type="entry name" value="BIFUNCTIONAL 3'-PHOSPHOADENOSINE 5'-PHOSPHOSULFATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11055:SF1">
        <property type="entry name" value="PAPS SYNTHETASE, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01583">
        <property type="entry name" value="APS_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword evidence="8 11 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="APS kinase" evidence="12">
        <location>
            <begin position="24"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDM30451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="211" mass="23615" checksum="52011530FAEE35CA" modified="2014-04-16" version="1">MSSNITFHASALTRSERTALRNQQGLTIWLTGLSASGKSTLAVELEHQLVRDRGVHAYRLDGDNIRFGLNKDLGFSEADRNENIRRIAEVAKLFADSNSIAITSFISPYRKDRDTARQLHEVATPGEETGLPFVEVYVDVPVEVAEQRDPKGLYKKAREGLIKEFTGISAPYEAPVNPEVHVKNYELPVQDAVKQIIDYLDSKGYLPSKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q3A2</accession>
    <name>W6Q3A2_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PROQFM164_S02g000910</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q3A2"/>
    <dbReference type="STRING" id="1365484.W6Q3A2"/>
    <dbReference type="OMA" id="WFRGKKG"/>
    <dbReference type="OrthoDB" id="1935484at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000106">
        <property type="entry name" value="MFS transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF65">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="198"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="233"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="268"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="380"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="410"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="509"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM30760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="567" mass="64876" checksum="0EC76F58CC0C62A7" modified="2014-04-16" version="1">MSTVYSTKKGPDESITVLKGTDTDSSTSLDIPPLGEPGDERRFWFQRGKDYNPEAIATQPSVFDNPDTAKEYQPRADWENLHRFDTSARWTWNEEYKLIRKIDLRIMVFACLMFMCLELDRSNLSQALTDNMLPELNMTTNDYNLGNTVFKLSFLSAELPSQLVSKWVGPDRWIPTQMVLWSAVAMAQYGLNGRTTFLLCRALLGILQGGFIPDVILYLSYFYKHHELSLRLGFFWTAMNIADILAAFLAFGFLHLRGVQGQSGWRWLFLLEGLLTLLFGLSAYILMPPGPCQTANWSRGKSGWFTAREETIIVNRVIRDDPSKGTMHNREPITPKLLWKSLKDYDLWPLYIIGLTFQTPVVPPKQYLTLTLKGLGFGTFVTNLLVIPSEVLSIIFLLLLTYASEICNQLTLVSTIGQIWMLPFLVYLYVIDINTANKWCVWAVITLLLSYPNAHAIQVNWNSRNSNTVRSRTVSAAMYNMCVQSSGIIASNIYRADDAPRYRRGNGTLVGLVVSNVFIYLLTKVYYVWRNQSRDKKWNAMTDNEKTNYLATTKDEGNKRLDFRFAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q3C8</accession>
    <name>W6Q3C8_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable kinetochore protein NUF2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Probable kinetochore protein nuf2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">nuf2</name>
        <name evidence="19" type="ORF">PROQFM164_S02g000950</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the NUF2 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q3C8"/>
    <dbReference type="STRING" id="1365484.W6Q3C8"/>
    <dbReference type="OMA" id="YLKMEAH"/>
    <dbReference type="OrthoDB" id="8194677at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031262">
        <property type="term" value="C:Ndc80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051315">
        <property type="term" value="P:attachment of mitotic spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051383">
        <property type="term" value="P:kinetochore organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045132">
        <property type="term" value="P:meiotic chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.60:FF:000003">
        <property type="entry name" value="Probable kinetochore protein nuf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.60">
        <property type="entry name" value="Ncd80 complex, Nuf2 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005549">
        <property type="entry name" value="Kinetochore_Nuf2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041112">
        <property type="entry name" value="Nuf2_DHR10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038275">
        <property type="entry name" value="Nuf2_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21650:SF2">
        <property type="entry name" value="KINETOCHORE PROTEIN NUF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21650">
        <property type="entry name" value="MEMBRALIN/KINETOCHORE PROTEIN NUF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03800">
        <property type="entry name" value="Nuf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18595">
        <property type="entry name" value="Nuf2_DHR10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="13" id="KW-0137">Centromere</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="10 15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="8" id="KW-0498">Mitosis</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinetochore protein Nuf2 N-terminal" evidence="17">
        <location>
            <begin position="34"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="Nuf2 DHR10-like" evidence="18">
        <location>
            <begin position="287"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="240"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="167"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="359"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00072418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF03800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF18595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CDM30800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="469" mass="54758" checksum="BEC47739A5C4B630" modified="2014-04-16" version="1">MSRNSTAMGYNSRMSQQFQGNQHHGRGRKKEDENDALMRLPDKEIAGCINDIGIPFTLADLAKPNAQQIQMVFEWFAELLMNTTRETVEPAMHAAAEDLCGDYPDIIPNDTRNLMGFFMMLRKLLAECGVNDFTFTDLTKPTHERLVKIFSYLINFVRFRESQTPVIDEHFNKTEKTKSRIDELLAENQEMELRLREMRQDLQSNEANVREKVSRNDALKARLLELGREQSRVAETLDRVKTERARRQQQLEEKTERTVRSRQEAEKLRPYVLESPASLQSSLAELSENLMREKASIDAMERRARALQTSSDTFTVVSNDVQGCVKLLDDISAEMQKEDEEESRAARTAEAISDRGNSVREVEQTEKLLQRQLARWVERIEALQKNAQEKAELAQARMEELRNVQKQLREERAEKQRDMERRRIRIEQTEKKMVDLKENIETEIQSAHDQYLKLESHIKLYMTEMEKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2024-10-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q3P7</accession>
    <name>W6Q3P7_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S02g000746</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q3P7"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM30596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="52" mass="5560" checksum="03A437A1D2E5B132" modified="2014-04-16" version="1">MLDTGKKGPVPCWMISSSHHCRTFPVSTSHSTTAPVMSLLSILSPSTGSRLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q440</accession>
    <name>W6Q440_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Malic enzyme</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">MAE1</name>
        <name evidence="14" type="ORF">PROQFM164_S02g001518</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(S)-malate + NAD(+) = pyruvate + CO2 + NADH</text>
            <dbReference type="Rhea" id="RHEA:12653"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.38"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>oxaloacetate + H(+) = pyruvate + CO2</text>
            <dbReference type="Rhea" id="RHEA:15641"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="EC" id="1.1.1.38"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="10">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="10">Divalent metal cations. Prefers magnesium or manganese.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the malic enzymes family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q440"/>
    <dbReference type="STRING" id="1365484.W6Q440"/>
    <dbReference type="OMA" id="QIVNHMV"/>
    <dbReference type="OrthoDB" id="5365701at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004471">
        <property type="term" value="F:malate dehydrogenase (decarboxylating) (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05312">
        <property type="entry name" value="NAD_bind_1_malic_enz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10380:FF:000001">
        <property type="entry name" value="NAD-dependent malic enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000055">
        <property type="entry name" value="NAD-dependent malic enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10380">
        <property type="entry name" value="Malic enzyme, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015884">
        <property type="entry name" value="Malic_enzyme_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012301">
        <property type="entry name" value="Malic_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037062">
        <property type="entry name" value="Malic_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012302">
        <property type="entry name" value="Malic_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001891">
        <property type="entry name" value="Malic_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010052">
        <property type="entry name" value="PRK13529.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23406">
        <property type="entry name" value="MALIC ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23406:SF34">
        <property type="entry name" value="NAD-DEPENDENT MALIC ENZYME, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00390">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03949">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000106">
        <property type="entry name" value="ME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00072">
        <property type="entry name" value="MALOXRDTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01274">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00919">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00331">
        <property type="entry name" value="MALIC_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="4 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Malic enzyme N-terminal" evidence="13">
        <location>
            <begin position="88"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="Malic enzyme NAD-binding" evidence="12">
        <location>
            <begin position="279"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="111"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="183"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="423"/>
        </location>
        <ligand>
            <name>(S)-malate</name>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="467"/>
        </location>
        <ligand>
            <name>(S)-malate</name>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00050168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00052591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDM31368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="574" mass="63592" checksum="14A049F2D4954731" modified="2014-04-16" version="1">MSDSSSKFRDLPRAPGPVICPYKGNHVLHGSKYNKGSAFPDHERSTFKLHSLLPPNIQTLDEQVQRAYEQYQSRAGDLAKNTFLASMKAQNDVLYYKLVQTNLKEMFSVIYTPTEGDAIQNYSRLFRKPEGCFLNINDQDNFDEYLSGFGTEEDVDYIVVSDGEEILGIGDQGVGAILISVAKLAITTLCAGIHPSRQLPVVLDCGTNNEELLDDKLYLGLRQRRVRGEKYDEFVDRFVAAARNRFPKAYIHFEDFGLDNARRILDRYKSKIPCFNDDIQGTGCVTLAAMLAGLEVSKVNLEDVRVVIFGSGTAGTGIADQVSDTIATKTGKSKDEASKQIWCIDKPGLLMKSMGDKLTEGQKPFARSDDGWSDSDRDLLSVVKKVRPHVLIGTSTKPGAFTEDVIRAMAEHVERPIIFPLSNPTRLHEAKPVDLYKWTDGRALVATGSPFPPVAHDGTQFEIAECNNSTCFPGIGLGAVLSQCRLVSKKMLVAAVEALKARSPALQDSMKPLLPDVEDVREISVDIATAVILCAVEEGLAQAEGIPTSESELREWIRIQMWEAEYRPLVYKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q587</accession>
    <name>W6Q587_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Armadillo-type fold</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PROQFM164_S02g001286</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q587"/>
    <dbReference type="STRING" id="1365484.W6Q587"/>
    <dbReference type="OMA" id="NPDQYTI"/>
    <dbReference type="OrthoDB" id="431626at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000373">
        <property type="entry name" value="Importin beta-5 subunit, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056840">
        <property type="entry name" value="HEAT_IPO9_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997">
        <property type="entry name" value="IMPORTIN-7, 8, 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997:SF9">
        <property type="entry name" value="IMPORTIN-9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25018">
        <property type="entry name" value="HEAT_IPO9_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="5">
        <location>
            <begin position="23"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDM31136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="1037" mass="113576" checksum="F9C4B1ED3D088D33" modified="2014-04-16" version="1">MEQELLSLLADTQSPKADTRRAAESQLESLYVHDSFAISLTAIASHESVPVNLRQSALSVLRTFIAAAWSPILDEFKGQILINDANKSSVRQALLVLATNDNPQRKVKNSASFAVSKIASADFPDDWPELLPSLLSIINNSASTDGQMHGALKVLLDLVDTGFSEEQFFNVARDLVSSLFAVATAESRRPMLRALAVAVFRSCFDTLEMVLEQHKTAIKQFMDEVLSGWSPFFDTALKAPLPQPPNEEEEHKQGEIASQWRGIVGLKLQVVKTLMKIRMVFPALLTAQSPIFFSTVWTELTNALPIYQNFYIEDNRQSRLEDADGLPHSLDFLVLEELDIIQALLKAPPVKAELQQQLQNAGATASTSSWLPEIMKLASSYAQITTEEEALWEIDVNLFLSEETSVTANYTPRTCSGDLAIKAGEWLKGTAAEGLLGYMNTVFADSSVSWKSREASLYILNCLLRDFGEVDQEISPELASHFTQFVQYATQQEQELLRARGYLVAGALSKVAGKAFQQTTSSYLEATLKAIAEDPAEVVQVACIRVLQDLMPALPKGLARPFQPAVIAAISEFISAHDLREQTDSDDLKVTLAETLRDTIMADSSVVLSSPAIDVLFNIASSGAENFQLTLTVTEAFEDIVDQITDSGPDSYMRLCEKVLPSLMGAIDVGNLTEENALTNFAADLLRALAERSPEPMPAGFVETVMPKLNRLLLNSDEAELIRPATEAVRHMLSHDFAQFIAWRDPQSGKEALEVVLVIIDRLLGPAVDDNAATEVGQLAAELVERAGSERLGPYLPQLLQAVAQRLATAQQAQFIQSLILVFARLTLISAHEVVDFLAQVNLGGQSGLTVVLSKWLENSVNFAGYDEIKQNIFALARLYELADPRVAEVPVKGDLIIQDTGRIKTRSQARKNPDQFTTVPAPLKIIKVLVEELGAASGNKEIDAAAAALDDADSDDDDDDWEDLPSQVLDLGIGATKQGLLNFGEGGSESVFGVRRRDDETQGFLVDFFRQASTQPGFQELYAALTPDEQAKLQSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q5J4</accession>
    <name>W6Q5J4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Short-chain dehydrogenase/reductase SDR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S02g002094</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q5J4"/>
    <dbReference type="STRING" id="1365484.W6Q5J4"/>
    <dbReference type="OMA" id="VESHGKC"/>
    <dbReference type="OrthoDB" id="542013at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF22">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE PHMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM31943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="321" mass="35952" checksum="36B7E535AF49ECBC" modified="2014-04-16" version="1">MAAIFRLLKMQYTPPLDPQGASFAAIKILNLGVELLIIGSRSIEKGNKAKVDLERATNRRNVVKVWQLEMNSFQSVKDFAERVHVELDRVDVALLNAGLWNREYYQSPEGWEETLQVNTLSTLMLAILLLPKLKKSSYVDNPTHLTLVSSQQFVRVKPASIQTDGSILAHVNDPDNFNGPKQYGISKLLLEIVIKKIANIVCNDDGTHTLVVNTVSPGLCISALGRKYSHWWEKCIVWVMHTFFARTTEQGSRSLVSATLQGLESQGKCWRSEGYLDESTALTTILEGEELQEKAWEEIIAVLEEQAPEVSLVARGLYQGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q5X5</accession>
    <name>W6Q5X5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S02g001536</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q5X5"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="51"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM31386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="95" mass="10226" checksum="75487900F9563FB8" modified="2014-04-16" version="1">MIIQWFQTSTHIRPWPQLDINYTQQVSPRSSDAYLALISGQRKSRPHLGMVPSSSTVPTLSTDLIAGSEGPGNPGCMRACVESGAGACLSFGSWM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q635</accession>
    <name>W6Q635_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">dihydropyrimidinase</fullName>
            <ecNumber evidence="6">3.5.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PROQFM164_S02g001901</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>5,6-dihydrouracil + H2O = 3-(carbamoylamino)propanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16121"/>
            <dbReference type="ChEBI" id="CHEBI:11892"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15901"/>
            <dbReference type="EC" id="3.5.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="PTM">
        <text evidence="7">Carbamylation allows a single lysine to coordinate two divalent metal cations.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.2" evidence="6"/>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q635"/>
    <dbReference type="STRING" id="1365484.W6Q635"/>
    <dbReference type="OMA" id="EYTPFEG"/>
    <dbReference type="OrthoDB" id="1924787at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004157">
        <property type="term" value="F:dihydropyrimidinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01314">
        <property type="entry name" value="D-HYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000174">
        <property type="entry name" value="Dihydropyrimidinase-related protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011778">
        <property type="entry name" value="Hydantoinase/dihydroPyrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050378">
        <property type="entry name" value="Metallo-dep_Hydrolases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02033">
        <property type="entry name" value="D-hydantoinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11647:SF1">
        <property type="entry name" value="COLLAPSIN RESPONSE MEDIATOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11647">
        <property type="entry name" value="HYDRANTOINASE/DIHYDROPYRIMIDINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="8">
        <location>
            <begin position="56"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-carboxylysine" evidence="7">
        <location>
            <position position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00036696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR611778-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM31750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="533" mass="58930" checksum="FE224BBCCFB867E7" modified="2014-04-16" version="1">MASKFDLVVLNGKVVTASDICDYCIGIKDGKIQTLAESFSEDEIAGAEVIDAEGAYVMPGGIDAHVHLCQDLKTGPHGLGGECADNFETGSRSAVAGGTTTIITFATQTRGEEDRSLIKVVESYNARAEETGSYVDYGFHIIIVRNDADVLETELPILKKDWGISSCKLFLTYETQRLTDSQLLDVMWAARKNSITTMIHAENGDMIAWLTQKLEEKGMNAPYYHALSRPPLVEGEATNRAIALAQLIQNPILFVHVGSALGAANVRRAQNMGLPVYAETCPQYFHLTWNDLKRFHSPTCFENSKMICSPPPPPDASDQEDLFVGLHNGTFTIYSSDHCPFRYNDPHGKASGVLEHAKSMEGESPHACDDLHDLLTRKEGSFKLIPNGIPGVETRLPLLYSGALSTGRISPQRFVELTSTNPAKLYGLYPKKGTLMPGSDADLVIWHPEKTFEPFHLTNAQLHHNVDYTPYEGFKMLNWPRYTILRGKVMWANGKILGKVRDGQYVKRGPSQLSQGLPGADRDPRRVAAWLYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q6B3</accession>
    <name>W6Q6B3_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Winged helix-turn-helix transcription repressor DNA-binding</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PROQFM164_S01g003622</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the HSF family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q6B3"/>
    <dbReference type="STRING" id="1365484.W6Q6B3"/>
    <dbReference type="OMA" id="QWGQNPP"/>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000173">
        <property type="entry name" value="Heat shock transcription factor Hsf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000232">
        <property type="entry name" value="HSF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015:SF427">
        <property type="entry name" value="HEAT SHOCK FACTOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015">
        <property type="entry name" value="HEAT SHOCK TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00447">
        <property type="entry name" value="HSF_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00056">
        <property type="entry name" value="HSFDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00415">
        <property type="entry name" value="HSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HSF-type DNA-binding" evidence="7">
        <location>
            <begin position="149"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="72"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="222"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="254"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="444"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="715"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="29"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="83"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="279"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="305"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="450"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="716"/>
            <end position="733"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM29809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="747" mass="81676" checksum="5C3DA9E0EB7A9189" modified="2014-04-16" version="1">MSSQGMTRKRPAPGTVPPVHPQMNPVPNFPTTANPGSQLSNDQFLQWGQNPPVNAINTSAFSDPTYNPVAFSSPQDVSAPAATASNQLARRQANQVVSRNRGYEQPPASYVENGGNNGNGESGAWGESLEELYRRALTAKRDSQAKRKQIPPFVQKLSSFLDESKNTELIRWSDDGNSFVVLDEDEFARTLIPELFKHNNYASFVRQLNMYGFHKKVGLSDNSMRASERKNKSPSEYANPYFKRGHPDLLWLIQKPKNAGGGGHASKPSKGGTRVKTEDIEDNEMDDYVEEGAPAPRDTRAPRPQQLSLATDSSVPNDQLSGVYRELQAIRQQQSIISTTITRLRKEHEQLYAQAANFQEQHTRHENSINAILTFLATVYNRSLQGEGGPQNLANSFAGAISQDQGNIVDVDDDYLNNALGSMASPSAQRTMKKPPLLLKAPPAAHAYNNRPSTISPSGSGSYDTRSRGHARQPSANQHGHVEEVFDHSPRTANVSPGQPTDQNSPQRDIMSVIQNSNARNGLSTNFSEFPNVLSSLENHGEPNAGVSPNNALISPNPPLMPHNYSGRLASTRQEIDNLVKMQAEQDRSVQNLTSLLQPLSPNGTIPGIDSEGNVPPPPLDLDQIFNNDYFTDIGDTGSDMKKQENPMDHLGAGQNTHDPMGTTQGDDTNDLFDFDHIPTEPDLFETPHNAQGDPTYNYGFDGVGYDESGRVIEQLTDSETTSPTATGNSSEAVNDGGSASKRRRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q6J7</accession>
    <name>W6Q6J7_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alcohol dehydrogenase superfamily, zinc-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S02g002121</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q6J7"/>
    <dbReference type="STRING" id="1365484.W6Q6J7"/>
    <dbReference type="OMA" id="TGITAYW"/>
    <dbReference type="OrthoDB" id="809632at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05288">
        <property type="entry name" value="PGDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000121">
        <property type="entry name" value="Prostaglandin reductase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041694">
        <property type="entry name" value="ADH_N_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045010">
        <property type="entry name" value="MDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205:SF42">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE, ZINC-CONTAINING (AFU_ORTHOLOGUE AFUA_7G04530)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205">
        <property type="entry name" value="PROSTAGLANDIN REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16884">
        <property type="entry name" value="ADH_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="2">
        <location>
            <begin position="21"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM31970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="344" mass="37857" checksum="A71BBEDBA0E312CA" modified="2014-04-16" version="1">MSSEHIAIHLQQRPETNIVPGETFAVQKHTTPTSEELEDGEVVLESLYLSLDPAMRGWLDDRPSYIPPVAIGEIMRGYAVGRVTASRSEKFPVGSYALGMVSWTEQAIINESSLESVPTPDPADGGHLTDFLSVLGLTGITAYWGMVEVGHVKPGDFVVVSGAAGATGSIAGQIAKIHGATVYGIAGSDEKCRWLVEDLKFDGALNYKSEDFAEKFKSLMQGKIDLFYDNVGGEVLDLALLCANKNARFVMCGGVSQYNEQEVKGPKNYMMIWRMRIRMEGFIVFDHMDKKPEIRRKLSQWLAEGRLQRRETIVHGGLSQAETALMQLYKGVNTGKLLVEVKAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q6V2</accession>
    <name>W6Q6V2_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Initiation factor eIF-4 gamma, MA3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PROQFM164_S02g002231</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CWC22 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q6V2"/>
    <dbReference type="STRING" id="1365484.W6Q6V2"/>
    <dbReference type="OMA" id="FMVDILN"/>
    <dbReference type="OrthoDB" id="361797at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000050">
        <property type="entry name" value="Nuclear protein (Sgd1), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050781">
        <property type="entry name" value="CWC22_splicing_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003891">
        <property type="entry name" value="Initiation_fac_eIF4g_MI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003890">
        <property type="entry name" value="MIF4G-like_typ-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18034">
        <property type="entry name" value="CELL CYCLE CONTROL PROTEIN CWF22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18034:SF4">
        <property type="entry name" value="NUCLEOLAR MIF4G DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02847">
        <property type="entry name" value="MA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02854">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00544">
        <property type="entry name" value="MA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00543">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51366">
        <property type="entry name" value="MI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MI" evidence="5">
        <location>
            <begin position="651"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="222"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="16"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="81"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="114"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="141"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="237"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="268"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="301"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="334"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDM32080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="889" mass="100246" checksum="82DA017E6D076690" modified="2014-04-16" version="1">MPKIPRPRHNTTALPRDLRSELGIRDVYGDKKRRLNGPASRKERRQNERTQKKSRHAAPPNKKTLEHPQQRLQQKPRQQDQEESDEDEDLDDMDLDEGPSVQTKSKSTKDAAKKPKSILKKAAVKQDSESESESGFGSEIDLNEDEDEDEDDESEDESEDESEDDSEDDIFEDEPKETEAHIPGSVKSKLAQDDAEIAALEKKLGLKKGGKLPKAFEEDGLDELLGDLGGGGDGSEDESKKRKREADEWLRSKRLKAKSLQTQQLEKDDSEMDSAEDFDLDDEIFGGDDAEGSDFDGFDEEERKEPKKKENPYIAPVTKPEPTAQKYIPPSLRGRSDPESESLTRLKRQAQGHLNKLSEANMLSIVAEFEKLYRDYPRQHVTSTLISLLMGLICERAALQDTFLILHAGFIAALYKLMGMDVGAEIIQTVVETLDADGDERGKFQGKEATNLVSLLSQLYNFHVIGSSLMFDYVRLFVQEITESNTELLLKVIRNSGPQLRLDDPSALKDIVLLIQPAITKVGEDRLSVRTKFMIDLITDLKNNRSKASAAAGAGITTEHITKMRKILGSLNNSRTIRASEPINISREDIHNSSKKGKWWLVGASWKDDPLVTAQREMAGVQMPQPQVEDDDSDGEPDFGVLARAHRMNTDVRRSIFVAIMSANDFQDANVRLMKLRLKRAQEFEIPRVLLHCAMEEEAYNPYYSLIARRICGEQGRRIKVSFMFALWNMFKKMGERGDIDEDEDNDFDPDDEENGVSMKSVVNLAKMFSALIMDGSLTLSILKNLNFAYLQPKTKTFVEVLIISIIQQSQKSKTKKKSKRSTPDEPEKNEAALMQIFLRVKETPHIAKGLIFFVRKVVAKSDIVSPEELKLVRWGCNVATDALKAVAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2024-10-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q6V9</accession>
    <name>W6Q6V9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S02g002594</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q6V9"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM32443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="82" mass="8987" checksum="B3E4015FD6B86442" modified="2014-04-16" version="1">MALIQTSQTFVDGGTKQQIHYWPWAIRKLVYPRVSETQNSIQSAISSNQAAISCVKTNEGSGPPAPGRYRVCVCVCVCVLFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q708</accession>
    <name>W6Q708_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">UPF0160 protein MYG1, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">Myg1</name>
        <name evidence="3" type="ORF">PROQFM164_S02g000198</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MYG1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q708"/>
    <dbReference type="STRING" id="1365484.W6Q708"/>
    <dbReference type="OMA" id="FHCDEVV"/>
    <dbReference type="OrthoDB" id="10265310at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003226">
        <property type="entry name" value="MYG1_exonuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11215">
        <property type="entry name" value="METAL DEPENDENT HYDROLASE - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11215:SF1">
        <property type="entry name" value="MYG1 EXONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03690">
        <property type="entry name" value="MYG1_exonuc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM30049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="372" mass="40829" checksum="0A1E846EF7E5F9D0" modified="2014-04-16" version="1">MLRFNNYFKMAENVAKKLKISSPLIGTHNGHFHADEALAVYLLRLLPTYASSPLIRTRDPAELEKCHTVVDVGGVYDPAIHRYDHHQRTFSTTFPQHATKLSSAGLVYMHFGKAILAQKLSLPVEHADVDLLYEKLYTDFIEAIDANDNGISAYDQAALSAAGVEKRFKNGGITLASMVGDMNNPDPTSPPGEPQDEDSLFGRASTLIGNAFARKMHHACTSWMPARTTVGGAYAARKDIHPSGRIIVLPQGGVPWKEHLYNFEAEASGTKEIDPAVQTYYVLYPENATEGAKWRVQCVSVSESSFESRKPLPESWRGVRDQDLDGVMAAEAEKNGQSKIPEGAVFVHASGFIGGHKTREGAMAMAERSLEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q7M5</accession>
    <name>W6Q7M5_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Transcription elongation factor Spt6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">spt6</name>
        <name evidence="13" type="ORF">PROQFM164_S02g002511</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Histone H3-H4 chaperone that plays a role in maintenance of chromatin structure during RNA polymerase II transcription elongation thereby repressing transcription initiation from cryptic promoters. Mediates the reassembly of nucleosomes onto the promoters of at least a selected set of genes during repression; the nucleosome reassembly is essential for transcriptional repression. Essential for viability.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Plays a role in maintenance of chromatin structure during RNA polymerase II transcription elongation thereby repressing transcription initiation from cryptic promoters. Mediates the reassembly of nucleosomes onto the promoters of at least a selected set of genes during repression; the nucleosome reassembly is essential for transcriptional repression.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the SPT6 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1365484.W6Q7M5"/>
    <dbReference type="OMA" id="GYFYLCF"/>
    <dbReference type="OrthoDB" id="995477at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008023">
        <property type="term" value="C:transcription elongation factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034728">
        <property type="term" value="P:nucleosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140673">
        <property type="term" value="P:transcription elongation-coupled chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09928">
        <property type="entry name" value="SH2_Cterm_SPT6_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09918">
        <property type="entry name" value="SH2_Nterm_SPT6_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2740:FF:000002">
        <property type="entry name" value="Transcription elongation factor Spt6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.650:FF:000004">
        <property type="entry name" value="Transcription elongation factor Spt6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.850:FF:000001">
        <property type="entry name" value="Transcription elongation factor spt6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3500.10:FF:000005">
        <property type="entry name" value="Transcription elongation factor Spt6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.140:FF:000007">
        <property type="entry name" value="Transcription elongation factor SPT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.505.10:FF:000056">
        <property type="entry name" value="Transcription elongation factor Spt6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.505.10:FF:000065">
        <property type="entry name" value="Transcription elongation factor SPT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.650">
        <property type="entry name" value="RuvA domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2740">
        <property type="entry name" value="Spt6, Death-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.850">
        <property type="entry name" value="Spt6, helix-hairpin-helix domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3500.10">
        <property type="entry name" value="Tex N-terminal region-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.140">
        <property type="entry name" value="YqgF/RNase H-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041692">
        <property type="entry name" value="HHH_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049540">
        <property type="entry name" value="Spt6-like_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028083">
        <property type="entry name" value="Spt6_acidic_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042066">
        <property type="entry name" value="Spt6_death-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032706">
        <property type="entry name" value="Spt6_HHH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028088">
        <property type="entry name" value="Spt6_HTH_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035420">
        <property type="entry name" value="Spt6_SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035018">
        <property type="entry name" value="Spt6_SH2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035019">
        <property type="entry name" value="Spt6_SH2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028231">
        <property type="entry name" value="Spt6_YqgF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055179">
        <property type="entry name" value="Tex-like_central_region"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023323">
        <property type="entry name" value="Tex-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023319">
        <property type="entry name" value="Tex-like_HTH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017072">
        <property type="entry name" value="TF_Spt6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037027">
        <property type="entry name" value="YqgF/RNaseH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10145">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR SPT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10145:SF6">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR SPT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14635">
        <property type="entry name" value="HHH_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17674">
        <property type="entry name" value="HHH_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14641">
        <property type="entry name" value="HTH_44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14633">
        <property type="entry name" value="SH2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14632">
        <property type="entry name" value="SPT6_acidic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21710">
        <property type="entry name" value="Spt6_S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22706">
        <property type="entry name" value="Tex_central_region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14639">
        <property type="entry name" value="YqgF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036947">
        <property type="entry name" value="Spt6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="RuvA domain 2-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158832">
        <property type="entry name" value="Tex N-terminal region-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="13" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="7 10" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="SH2" evidence="12">
        <location>
            <begin position="1219"/>
            <end position="1309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1173"/>
            <end position="1212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="11"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="41"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1173"/>
            <end position="1208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00093389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR036947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDM32360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="1411" mass="161698" checksum="1929A303EAA0FDAD" modified="2014-04-16" version="1">MSLRDLIEGEAVMDDDDEEVADDYDAEGRQGAGAANHYNDSSEEEDEEEDDEEAARAVREGFIVDEDEEDERAARKHRKRPRAAREEEHLDEEDLELIGHGPSQHRGPATDSKFKRLKRGKDRESYQQSHGVDDIFNSDEEEEAQQYARPGQRRGLRDEMDDFIEEDTFSDDEAQRERDDLGVAPASRVNKTGLIPTDTSGLDENALEDMRAAFGDGTEYDFALQMEDQEDADKQTEERHLDLKDVFEPSELAERMLTEDDNEIRLLDEPERHQVARKPYKHVTLTEDQFREEAVWISNLMLLKKRMDPELREPFQRSVAKMLEFLITDDWEVPFIFQHRKDYMIHAVKDMANGADPDDESAKYSIRAEKLLNMTDLWDIFDHDLKFRALIDKRGTIKKTYDNLQSLFNVNDSNVEDQLIAATSMEELQDVQDYIHFQYSSQLRDLNQVNGDATGETQRRKATGRSFFERVRNGKAYGFVRAFGITADAFAQNASKEGRRQYTEDPTEQPEDLADQFVDNDFSNSSHVLKAAKSMFAEELAVSPKMRKVIRQAYYMNGVVDCFRTEKGLRRIDEQHPYAEFKYLRNQQLSDIARRPEMFLRMLKAEEEGLVDVRVRFENFDQFRKRLYADIESDNYSELADAWNRVRREVLDLALGKLEKLINRSVKENIRQECENHVAKECREAFSQRLDQAPYKPKGMVLGTVPRVLTLSTGSGQLGRDPIHWAYTEEDGRVLENGKFFDLSVGDESRDIADGENLAAFLDLMDRRRPDVIGVSGMTPETRRLYKLLSEIVEQKDIRGASYTNEHDEEISDPLEVVIVNDEVARLYHNSPRARSDNPGFGPLTHYCVALGRYLQSPLKEYASLGRDVVSIQFKPGQQLVSQDLLLKQLETALVDMVNLVGVDLNEAVADTATANLLPYVCGLGPRKAAHLLKIVNMNGGVVNNRVELLGVNATYPAMGVKVWNNCASFVYIDFENADPDADPLDNTRVHPEDYDIARKMAADALELDEEDIKAETDENGTGAIMRKLFREEAQDRVNDLILEEYAEQLEKNLNQRKRATLETIRAELQQPYEELRKHYVFLSTDDIFTMLTGETPDSLTPGMVVPIAIKRVFEDHIEAKLDCGVDVLVAETELGVPYEIPVRNVYQVHQTVPAKILFLNRKGFSCNVSLREDQVSHPSRRNQDHGFGDWDEQQEKADKESLQEKTQRGGQAMRVIKHPLFRPFNSTQAEEFLGSQSPGDVVIRPSSRGPDHLAVTWKVAQGVYQHIDVLELDKENEFSVGRVLKVGGRYTYSDLDDLIVNHVKAMAKKVGEMVFHEKFQEGSKAETDQWLDTYTKANPRRSAYAFCINPKYPGYFYLCFKAGEHARLQNWPVKVIPQGYELQKNPYPDMNALCNGFKLMFSNMSKGNRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q7S4</accession>
    <name>W6Q7S4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein kinase-like domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S02g002596</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q7S4"/>
    <dbReference type="STRING" id="1365484.W6Q7S4"/>
    <dbReference type="OMA" id="EWRNKWI"/>
    <dbReference type="OrthoDB" id="2906425at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF54">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="88"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM32445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="296" mass="34829" checksum="905B55878BBD4FD0" modified="2014-04-16" version="1">MTKFSPKNLPDESMREMNFLDSSFFKEPSKSLPTPAQVRALSKDIHANPQPQPVIFEESKVFVKFGPYVTIAEAQCLWMIKRTFGDEIPVPEVFGWRVDEENYVFLYMELIQGQTLQDGWNELNSQDKSSLCDELCQIVNRLRRFEQDPSDQYIGSLGHQQLLDYVFQSYPKTGPFFTIKDFNDWFSYLPQSWLPPSKKYNDPYRCLLPDSGVIKFTHGDLHRGNIIISSSKPARIIAIVDWAQAGWYPDYWEYCKALYTCWYEDEWRRDWVDNFLSPRLREFEVFAEYTMAMGSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q8F6</accession>
    <name>W6Q8F6_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="9">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PROQFM164_S02g000673</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q8F6"/>
    <dbReference type="STRING" id="1365484.W6Q8F6"/>
    <dbReference type="OMA" id="KVGYKIW"/>
    <dbReference type="OrthoDB" id="65569at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000134">
        <property type="entry name" value="MFS sugar transporter protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF79">
        <property type="entry name" value="LACTOSE PERMEASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G01860)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="123"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="180"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="215"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="304"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="342"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="370"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="399"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="443"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="470"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="55"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM30524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="538" mass="59316" checksum="5611AC40D57A5517" modified="2014-04-16" version="1">MASDAGYAEAKLGKGENREHIEEIVLARVTEEDLWKLSEDSLSLRSWTGVRLGLIMFIHGCNQAGFGIDWGVISGINALDQWHGYFGFGSSGGTYGLINALMQIGVVCGAPFMGLADVIGRRGINFTGNAIVIFASLMQGLATNLPIFMAGRFFMGFGTSLMSSSQYIGEISPIHLRGVMVGFFGACFQVGSLAMLGAMIGLTELPGNNSWRVPLILEALFPTIVCLGIYLITPESPRYYILRGNRQKAKEVIAKYHTTSTDIHEPIVDIVVRQIEESLENDQTGYRAAWDYRVFFTKAARFRLLVLFLYSLFQQWNGGGIITYYMVPSLQQLGIKSEKQLLGINIGTTAVYFVFTAAGALIVDKFRRRTMIFVGLISMIVFQTATTITSWQYSLHATTAAAALTILWIFLYQTFSATFVATMHNLYPIEILSLPLRAKGMGLYGLIQGGAGAAQTYGIGVGIQKVGYKIWVVYIVYNSIQLVLSWLFFPETSRLSLEEINTVFETPGVHPVKMSLDIQKAKKVRAAASRNEEGSANR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q8M2</accession>
    <name>W6Q8M2_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S02g002886</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q8M2"/>
    <dbReference type="OrthoDB" id="4290543at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM32735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="104" mass="11388" checksum="8445DE7F2968BDE4" modified="2014-04-16" version="1">MPSRPSDTISSARPFGARSSVALENPALSGFSDLGSFGGSYSHVLNLSKTRLKPTIIRTPRDYISATSTQSVGRDIPVFCAPVRQDQKWEALANHLNNNRRMVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W6QA10</accession>
    <name>W6QA10_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S01g000431</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QA10"/>
    <dbReference type="STRING" id="1365484.W6QA10"/>
    <dbReference type="OrthoDB" id="4369561at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM26622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="96" mass="10965" checksum="A5E540FFCD0D2197" modified="2014-04-16" version="1">MVESNSDLKPVYFFTFVPDPSLMLSRPYTAVILGKHSTYTSDKNALLVRLKEKEAMSWSKITTHFLGRNISSLQVHYSTKLRYKASSRSGRPKGHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W6QB22</accession>
    <name>W6QB22_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nucleotide-binding, alpha-beta plait</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S01g000716</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QB22"/>
    <dbReference type="STRING" id="1365484.W6QB22"/>
    <dbReference type="OMA" id="PLIRCDV"/>
    <dbReference type="OrthoDB" id="5970at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12467">
        <property type="entry name" value="RRM_Srp1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000123">
        <property type="entry name" value="Pre-mRNA splicing factor (Srp1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034403">
        <property type="entry name" value="Srp1p_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050907">
        <property type="entry name" value="SRSF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23147">
        <property type="entry name" value="SERINE/ARGININE RICH SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="7"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="89"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="100"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="124"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="141"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM26907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="241" mass="28575" checksum="F1563923467EDE14" modified="2014-04-16" version="1">MSSRSGTTLYVTGFGHGTRARDLAYEFERYGRLVRCDIPAPRTPSSRLFAFVEYESRRDADDAYHEMHNKRIGRDDLLKIEWARTPPSASWRFDSGSGRDAPRDAPRDAGRDAGRDRRRDRTPPRRGRSPSPRRSRGGDYSPRRDDRYERDADRTDRDYDRRDRDPDRRDRDHDRRDRDRSRDRSRSPDDRERDGKDDRERRDDDRERREEDRENGPNGEDRKAVPLDPMPSAHDELDTAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W6QB82</accession>
    <name>W6QB82_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major facilitator superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PROQFM164_S03g000449</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QB82"/>
    <dbReference type="OMA" id="RTIGPMV"/>
    <dbReference type="OrthoDB" id="10262656at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504:SF6">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G08740)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="183"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="207"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="241"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="294"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="393"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="450"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="484"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="582"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="109"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="39"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM33725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="619" mass="68527" checksum="FA69336E04491F1E" modified="2014-04-16" version="1">MGTSPQIQNHGQDRHEGPEYVHPVSQDGFDLTGHHVDLSDTESDSDLESDDTAIFGNPQPRRLESAPLITSRRRFSSIDEDNDHDGVLGPVEEDEEKPVTWSSLPKKGQLAILTLARLSEPLTQTSLQAYLFYQLKSFDPSLPDSKISAQAGMLQGCFTAAQFITAVWWGRLADAEWMGRKRVLLIGLMGTCLSCIGFGFSRSFATAMVFRTLGGVLNSNVGVMRTLIAEIIAEKKYQSRAFLLLPMCFNIGVIIGPILGGTLADPINSFPQFFGPGSTIGGKDGVWWMQHWPYALPNLLSAVFIFTSFLAVFLGLDETHEIARYRKDWGRKMGKRLTRAWARRPRHYRPLTRSSDDDSVYTDGSLGAWSTPSSPARSRVHPRPHKKIGFCQIWTRNIVLTLVAHFLLAFHTSAFNSMTFVFLPAPRAPENSRQGLFHFGGGLGLPSSRVGLATAIIGFIGLPLQIFLYPMIQTKLGTLTSFRTFLPFSPIAYVLMPFLVVLPRIPWIIWPSFTFVISLQVISRTFILPAAIILVNNCVTDPSILGTVHGVAQSIASAGRTMGPFLGGWGLGLGLENNMIGAVWWALAVESLLGWAMLWSIYEGKGIEHKKDEIEEDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W6QBG8</accession>
    <name>W6QBG8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta hydrolase fold-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S03g000095</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QBG8"/>
    <dbReference type="STRING" id="1365484.W6QBG8"/>
    <dbReference type="OMA" id="KGVGHWH"/>
    <dbReference type="OrthoDB" id="408373at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046464">
        <property type="term" value="P:acylglycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050266">
        <property type="entry name" value="AB_hydrolase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798">
        <property type="entry name" value="MONOACYLGLYCEROL LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798:SF5">
        <property type="entry name" value="MONOACYLGLYCEROL LIPASE ABHD6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="28"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM33371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="266" mass="28520" checksum="8D453A0CB9D32DC6" modified="2014-04-16" version="1">MPFVQANSHRLYYADSHPAGPPKNGLTFIFIHGLGSSQNYYYPVIPHLTKLHRCITLDTYGAARSPYTNDTITIPSIAEDVIGALDSLHIAKAVVVGHSMGGLVVLELGARIPDRVLGVVAIGPTHPSDMLVGVMNRRSDTVLESGMEPMADTIPSGAVGSRSTPLQKAFIRELVLGQDPKGYAAMCRAIAAAKPPNYAAVKEPFLLIAGEEDKSASMEGCRYIFEHVSSEKKSLEVLKGVGHWHCIEAADEVGELIAKFADSVNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W6QCS4</accession>
    <name>W6QCS4_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MICOS complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S03g001232</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QCS4"/>
    <dbReference type="STRING" id="1365484.W6QCS4"/>
    <dbReference type="OMA" id="GVAHSGM"/>
    <dbReference type="OrthoDB" id="2399148at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061617">
        <property type="term" value="C:MICOS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044284">
        <property type="term" value="C:mitochondrial crista junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042407">
        <property type="term" value="P:cristae formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019166">
        <property type="entry name" value="MIC26/MIC27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033181">
        <property type="entry name" value="Mic26_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28268">
        <property type="entry name" value="MICOS SUBUNIT MIC26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28268:SF1">
        <property type="entry name" value="MICOS SUBUNIT MIC26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09769">
        <property type="entry name" value="ApoO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="1" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="44"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="69"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM34508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="252" mass="27348" checksum="6BA9BB730C6515E8" modified="2014-04-16" version="1">MSFRPMLQQRAVAPIAATLLAGGMALYPKNTAFAEEPRDYRKPIYDDLPADIPETSKLPQPAAPATPKSISAPAAQQAPSSPTPTDILTAQVRQARLFLYSHSLAAEQGFNNFLSRALNIENYFTNTVASLAPSAESGERLLPGGVYVVVAAMAGSIVSRNRGIFLRTASPLAFGTAAAYSLLPVTMRNVGDLVWEYEKKVPALADKHLAARERAEHIWYTGIAHSGMARQMMEEKIGNTRKKLEELVSKGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W6QCY9</accession>
    <name>W6QCY9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Initiation factor 2B-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PROQFM164_S03g001049</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the eIF-2B alpha/beta/delta subunits family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QCY9"/>
    <dbReference type="STRING" id="1365484.W6QCY9"/>
    <dbReference type="OMA" id="NTYFEWV"/>
    <dbReference type="OrthoDB" id="206213at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046523">
        <property type="term" value="F:S-methyl-5-thioribose-1-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18872">
        <property type="entry name" value="NUDIX_eIF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10470">
        <property type="entry name" value="Translation initiation factor eif-2b, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000649">
        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042529">
        <property type="entry name" value="IF_2B-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43475">
        <property type="entry name" value="METHYLTHIORIBOSE-1-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43475:SF3">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_2G14290)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01008">
        <property type="entry name" value="IF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="4">
        <location>
            <begin position="5"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDM34325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="521" mass="58396" checksum="D46CA3A4207E98D8" modified="2014-04-16" version="1">MKSLKPRSVVSSFICSNAGEPKIAIFRRSDKVSTYQHHLAPISGSIESPESPLAAAWRELREETTLTSRDMELWRQGKAFTFSDPSVGRQWTIFPFLYRLKDCSEGGRGEAGLQIDWEHEGWQWYSPDAIQDDDKFGGVPHLKESFRRVWFEVDMNDGASKALITGLKQLKADHQSGSHELTSIALRAYRDVIAQMHEDIDTQWWKNARMAAWHLWKNGRESMGAATLNAFLGLLADMEVIIHENLDSTVKRERLLALIDQHLDKRKEMPMRIKHSFATYLESKFLSTTRSRPTPSLVILTLSSSSTIRDSIIEAFASLPIPNLDLRILESRPLCEGVNMASSILSAFKTRFPSSSDRHLKLTVYTDASAALASKDVDFILLGADRISDSGSVSNKTGSLPAVLSAKHVCPAAKVLVLSELEKVAEPDAESNRSQEENDPKELVGCWVEYGIKGLNAIAEGIDADRDNTNYTVEVKNIYFEWVPAELIEAYICEEGTLDATAIQEKAQQVKQKADRYFGQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W6QCZ5</accession>
    <name>W6QCZ5_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GTP cyclohydrolase 1</fullName>
            <ecNumber evidence="3">3.5.4.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">GTP cyclohydrolase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PROQFM164_S02g002215</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GTP cyclohydrolase I family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.16" evidence="3"/>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QCZ5"/>
    <dbReference type="STRING" id="1365484.W6QCZ5"/>
    <dbReference type="OrthoDB" id="4966at2759"/>
    <dbReference type="UniPathway" id="UPA00848">
        <property type="reaction ID" value="UER00151"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003934">
        <property type="term" value="F:GTP cyclohydrolase I activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046656">
        <property type="term" value="P:folic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006729">
        <property type="term" value="P:tetrahydrobiopterin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043133">
        <property type="entry name" value="GTP-CH-I_C/QueF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001474">
        <property type="entry name" value="GTP_CycHdrlase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020602">
        <property type="entry name" value="GTP_CycHdrlase_I_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11109:SF7">
        <property type="entry name" value="GTP CYCLOHYDROLASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11109">
        <property type="entry name" value="GTP CYCLOHYDROLASE I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01227">
        <property type="entry name" value="GTP_cyclohydroI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55620">
        <property type="entry name" value="Tetrahydrobiopterin biosynthesis enzymes-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0289">Folate biosynthesis</keyword>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GTP cyclohydrolase I" evidence="8">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM32064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="78" mass="8977" checksum="3DE48D5AF2EDDC55" modified="2014-04-16" version="1">MFSHRLHIQERLTKQVARAISGVLKPQGVSILMQPSYLCMAMRGVQKVGNTTITGCMLRYMQSRAIDREEFLELLHRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W6QDX7</accession>
    <name>W6QDX7_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Zinc finger, RING/FYVE/PHD-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PROQFM164_S01g001578</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QDX7"/>
    <dbReference type="STRING" id="1365484.W6QDX7"/>
    <dbReference type="OMA" id="PGCSICT"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16454">
        <property type="entry name" value="RING-H2_PA-TM-RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46539">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE ATL42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46539:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE ATL42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="2 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013402430" evidence="11">
        <location>
            <begin position="16"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="191"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="12">
        <location>
            <begin position="324"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="290"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="373"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="437"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="448"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="473"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDM27767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="498" mass="54330" checksum="D7BD31AB68659A7E" modified="2014-04-16" version="1">MGLFLFFLLFFSVQAEVVSLPSNTTVRIQSTGFRIEGSTLTGQNLVPLTNSLIQSTDDKLKAFNVSGVVTRVIPSNSLDLKSSQIAFISCDQDEYTGNIRVGQTIEYVTSGSAAILLYSKTAIGCNLTSNDPIANRYPNIFTFTSQGGYSALLRAFDNTTTISIVSMSYLSGVPSDSDSGGTGDSPNTAMIILYSITGIITALFLGIIITGAVRAHRHPERYGPRRIAGRVRQSRARGIARAMLDTIPVVKFDEKNDDVEAAKRDVEMTISPEDREHSEPQADGHTEISTLHESEMPTPDDNERPTPTAPEAKTEVHDGGNFSCPICTDDFVKGQDLRVLPCNHQFHVECIDPWLMNVSGTCPLCRIDLNPPQPENPEEENVDQPGQPAEGGPNQTAEEAHRHTHRRLTNYLHGPLNARRMRDATVEERLAALRHVREASQGEPAPEGEAHRGLTTRLRDRFRIRTRAHGAEAETPADADTAPSPAAPATVHLTPSTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W6QEG6</accession>
    <name>W6QEG6_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Altered inheritance of mitochondria protein 9, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Found in mitochondrial proteome protein 29</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PROQFM164_S04g000009</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AIM9 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QEG6"/>
    <dbReference type="STRING" id="1365484.W6QEG6"/>
    <dbReference type="OMA" id="RLFHYCF"/>
    <dbReference type="OrthoDB" id="2831558at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051035">
        <property type="entry name" value="Mito_inheritance_9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36091">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36091:SF1">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM35128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="544" mass="62233" checksum="343C643DFFAEC197" modified="2014-04-16" version="1">MGNKNSAPSPHTWLDSTSPGTDLQELTRRHDPHSYSGGRWLNRDELERNSRHVIFDFSALCERAVHICPGATSILNYEKREGGFNKVFLLTMDNGPCVVARVPTGITGPPRLTTNSEVATITYLQSKISLPIPKILDWNDNPSNPTGTEYIIQEHVTGIQLHQQWHKMNPEQHMLCTKALLLTMKKMASIDFPAYGSLYFADAPLDSDSKIPFEQGFCVGPHYSPVFWNRNPGEHELYYGPSPNCGPWRDLTSYYRGLIDTGFSRLPKEAVNDRKLLPYQGSIQDHIRILKISREVIQKLIEDKCIQDAAIPALLHPDFHKRNIYVSAEELTVITGLIDWQSTSIKPAFMYANETPDFAALPRIPEEDPLENEQNETEIFGQKEQELKDVSVCYQTYDVVMTALVPKLRPVRLLDPTLFRLFHYCHTTWRDSAVAVRQELIELSARWVELGLERSCPYSPTEAELKQHARDYEDFEAVQALKSWLRDNLDTNSDGWIPNDIWDTARVAHRTAYDEWIQTAKEAESRGEDMTVAKADKMWPFDAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W6QEP0</accession>
    <name>W6QEP0_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g001863</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QEP0"/>
    <dbReference type="STRING" id="1365484.W6QEP0"/>
    <dbReference type="OMA" id="NDTRIFS"/>
    <dbReference type="OrthoDB" id="5346713at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902412">
        <property type="term" value="P:regulation of mitotic cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045342">
        <property type="entry name" value="Etd1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20162">
        <property type="entry name" value="Etd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="331"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="406"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="652"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="681"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="858"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="343"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="683"/>
            <end position="700"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM28052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="1016" mass="110956" checksum="10EA6ADA7640EE47" modified="2014-04-16" version="1">MDHISTLCALSTVGIAPTGLALGRAERTQRPGLFRRKTLFQDILEPLPNNSEQTAVARPKTALSSRSPAAEWLAAKEQESLQGNQESNLRKAPLSFSGARRRRRGQTLTNPPLRIPENESTDSPVEIQTQRPSSGWLRRLSMASFQAETPTAGSPTTPSFNGSESPLVPRSPYLRRTPNKLVKRPASQHTNTHALCMNPISEPSPAALRRPATSHQRSESMFLRTSSTTDFNAYFPKTPVEGPAIEEFELEKKKHWMPFFVPKAGKLAERLSRRFSTSTAPKVQSVRQIASDNGALPVLVAANMISPTAAAPEDISVPNTPIEFRNPFQMPISEPTPKESVAPEQQTAKSGHKQSYSVNDIEPKIIMANTVTAHGTPIMGPVRGGSLKRVKGRTFSIPASELSIEEQNVPIPNSSEPEPRRNITDPSVFRAPYPTSQSGWADSALERRSQVGPRSVSQDYSVGLGPRAGARQMTSDAVALSAWQQASRPGGRPHGSLRRRPKGFSISCSDPASTVIGSDDTQVFTSCDGYETDFISDYWDSVRTRETNRSGLKGLRIETMFDKAGTSLVNEEATTLESLLPRGSFAARSSDKDPQLFTDPLLSSPPLVQTSMVETPFVADDDAFSMIGALPSNDRDCFSSSLTYSLAKLAEQPDSGTGAAKDMSESVGDLESDVNKKTNIFDWSEHAHHTRETSDSEARPKTMQGKQEGVVDRSRAVCRKAPSTVHLRSQSVPVASELPINESRQTSGKFGTWGLGTKGVSEDWDSDFDFDEAEDTPVAEDKPLVEPDINRQSMTVPKAILERQASLRGQFGQVQELTMLVEELKRLRHQANVLRIVNGPASELWAEAEQIVNLATIDDDEARRSPPGSPQSLTFSFDESDDDGLNGSSKRNSEVSWDVPSGENKAMLPLAQLVKDSQKSKSVLDILQPRGQEPSLGLDGSELASRGKKLPFDTSSLKNLVVRAGVVTRALKEVIRKADGVADSPQDFQDPPFRRIFDKPSHDDIASFEAALADMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W6QEU0</accession>
    <name>W6QEU0_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ankyrin repeat-containing domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S04g000114</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QEU0"/>
    <dbReference type="STRING" id="1365484.W6QEU0"/>
    <dbReference type="OrthoDB" id="366390at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF194">
        <property type="entry name" value="INVERSIN-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="392"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="392"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM35233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="463" mass="51976" checksum="F424F431A49FB05A" modified="2014-04-16" version="1">MTIAARNGHLKILQLFVENLPSIITNSARSWYLLMHAALRGQLHVVKFLIGQGVPVIHVDKSARTSSIVDAAVLKGHLPVVKYIIEEIKFADRSHNSADPLLCLATHAGHLDMVKYLVKCGASFTCQHFYPFHGSAFDIAMDEGWADIASFFLGNATLEDLDIITTSGWKWMSKPCSQDKFGHIFYPSPWKKPSIAHMILDRVDLEKQLTTITPDNEQEVRGRQFHYPNGRPRLDHIHPRSSIQLLVEHGAEINQVDANGRTALFLTTERNNLVLTKELLRLGANPLLKTSANVSALELAISKCQTKHVKAFLKAIEIHSFTCDNFSSLNPDVLPPEKLPNRAPTCASAQFHIFATDFLSVEGIIARNGWMDQPRGSRVPVWCRKSPQNWEEILEESSEESSEEDSDESSGEGSDEEWDNYSVSLQKEGTEEDNFVPIWSATKDDDSISDPRWARFFIAKAMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W6QEV8</accession>
    <name>W6QEV8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Mg2+ transporter protein, CorA-like/Zinc transport protein ZntB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PROQFM164_S01g001933</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QEV8"/>
    <dbReference type="STRING" id="1365484.W6QEV8"/>
    <dbReference type="OMA" id="CNENYQV"/>
    <dbReference type="OrthoDB" id="29879at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010961">
        <property type="term" value="P:intracellular magnesium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12829">
        <property type="entry name" value="Alr1p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.340:FF:000006">
        <property type="entry name" value="CorA family metal ion transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.340:FF:000008">
        <property type="entry name" value="CorA family metal ion transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.460.20:FF:000002">
        <property type="entry name" value="Cora family metal ion transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.20">
        <property type="entry name" value="CorA soluble domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044089">
        <property type="entry name" value="Alr1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045861">
        <property type="entry name" value="CorA_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21535">
        <property type="entry name" value="MAGNESIUM AND COBALT TRANSPORT PROTEIN/MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21535:SF55">
        <property type="entry name" value="MAGNESIUM TRANSPORTER ALR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143865">
        <property type="entry name" value="CorA soluble domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="588"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="619"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="34"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="125"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="252"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="125"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="141"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="272"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM28122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="646" mass="72782" checksum="0C4B1706C4BBEFBD" modified="2014-04-16" version="1">MSESPRSEKYMYLTRYSTPVPELDDHRLQMQTPPRIEAPMERSYSPRDTTQGPEMLDRPDLLSAQDVLQDGPIPRDFENAAEDDRSLNEFNGLGRFSIDHNATYQTPRRISVVNPELANASCASSVSARSSSPPNSVEAFADPRRRERANTLDSHAPPDLEAILQRTVSGGTHNRRPTFSNASVVRPQLGDVPFDTAEEACFDAPGRIPVIDYEELEEFVALNPSSKIADGDRRKHSMSSQSKRPRIFYDLRPGAESPEMGPIQKTSSTDTLSEHEKKDAEVTDEKERVRQPHTTNQRSRFGFFSSESQSTVHAADLGDLVLPGETFRDLFELGPEGGVWWLDVVNPTDEELGAISRAFSIHPLTTEDIQTQEAREKVELFKQYYFVCFRTFFQMDKTSEEFLEPVNFYMVVFRDGVLTFSFEDNPHASNVRKRIGKLRDYVSLSSDWICYAMIDDIVDSFGPVIRDVELESEAIEDHVFIARVEDFESFLPRIGGLRKKVMSLMRLLGGKADVIRGFSKRCNEQYSVTPRGDIGLYLGDIQDHVVTMMSNLAHFEKMLSRSHTNYLAQLNVTNLVLGNHVNKVLSKVTLIATILVPMNLICGLFGMNVEVPGAHTEGLAWWFGILGVIAGIVVVSFGLARWQRLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W6QF75</accession>
    <name>W6QF75_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S04</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S04g000026</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QF75"/>
    <dbReference type="OMA" id="ICRDYHA"/>
    <dbReference type="OrthoDB" id="4215089at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM35145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="286" mass="32258" checksum="5DEA5EB9217795EA" modified="2014-04-16" version="1">MEDEGFDRPFGFIVTGQYLAIHYHGNDFEICRDYHARGALFYLSDDGETIIHNRTYVGALTDYPDYEGDVFYIRNGSRYLAQDGQWTDHTHDAIKVQIDPAGDYGDAEPPIPPSISNPVVDPGNPISADGVDLYHPDKWFSLYPITGDSIWSGDAGELETKLYFGGNPYSDGRCFQLSEHDGKTRIRSYEGKYLVVLMEPSIAAYLDEGCKGHTRFDRCSRCKLHYTIGYSSEPDGGLFLVPRGLPSMFVLNDGLFYYKVDVLKGSYSEVKRVEDMDDASFFQFVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W6QF81</accession>
    <name>W6QF81_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S02g002920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QF81"/>
    <dbReference type="STRING" id="1365484.W6QF81"/>
    <dbReference type="OMA" id="NPSHRTE"/>
    <dbReference type="OrthoDB" id="5986190at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM32769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="224" mass="24651" checksum="4A46C4432CA51D9B" modified="2014-04-16" version="1">MASTSHSGVNHGAQVGINYGTFTALFHLPPEPPETPPSPLSTVPFTRGPDFVRRETLLDQIYGKNSVAGSRIALIGLGGVGKSQLAIEYSYQVRSKSPTTWVFWVHASNEARFEQSFRDIADQVKIPGRQAICLAFSIGLLGCIFTARFCGAREKRPWRHLATEKIVTSKVVLSLGENLEGICILSILYTPNPSHRTEASIMGGRRKLEGRRQDETKMTEHSLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W6QF83</accession>
    <name>W6QF83_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Arf GTPase activating protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S04g000036</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QF83"/>
    <dbReference type="STRING" id="1365484.W6QF83"/>
    <dbReference type="OMA" id="SDCKRNK"/>
    <dbReference type="OrthoDB" id="10266696at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08839">
        <property type="entry name" value="ArfGap_SMAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.150:FF:000010">
        <property type="entry name" value="Stromal membrane-associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051718">
        <property type="entry name" value="ARF_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044732">
        <property type="entry name" value="ArfGAP_SMAP1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45705">
        <property type="entry name" value="FI20236P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45705:SF1">
        <property type="entry name" value="FI20236P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Arf-GAP" evidence="3">
        <location>
            <begin position="15"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="173"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="258"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="466"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="220"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="259"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="336"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="470"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="503"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="532"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="548"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM35155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="557" mass="58320" checksum="1037077C91AC2024" modified="2014-04-16" version="1">MSSRRPTPGQAAQNTQAIKTLLKLEHNKICADCKRNKHPRWASWNLGVFVCIRCSGIHRGMGTHISRVKSVDLDSWTDEQLQSVVRWGNGRANKYWEAKLAPGHVPSDAKIENFIRTKYESKRWVMDGGIPDPSTLDDGDDDVEKAKIERSASQRAAAASQPPVHRQQASIDLFGDDISPPNRPSTTEPAPRLPPRQAQPAPAKIHKPNDSLLGLDFFGSTQPSTGSRPSSTTSTPATPAGMSRPDLKQSILSLYSKPQPASTVQHQRGNSFGDMASPPAPSASSHMGGLTDAFSGLSFPTTTSPPLAKPAEKPSAFSNLSSFGGAKSTPAAPKVTSPSGSTGDFFDSFTSATVSAPKSQSRTTSISSGLDFGFGGFTSPTVKPNPPSSSLSNDLFGFSSPTTKASTVPPPKPTATSPRQEMRSAFNISAPPMQPPAPLKAPATSAANAAAASMMSGSFDPWGGNAWSTPDHASSPHAVPSPASMMKVPDTLTPNDVGHGWGAPSAAASKPAPTVAADEDFGGWASAAPVSHPTSTSTNNKSSGFGGSDDLFSNVWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W6QFH9</accession>
    <name>W6QFH9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S01g002153</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QFH9"/>
    <dbReference type="STRING" id="1365484.W6QFH9"/>
    <dbReference type="OMA" id="NGHCIVA"/>
    <dbReference type="OrthoDB" id="10003767at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051035">
        <property type="entry name" value="Mito_inheritance_9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36091">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36091:SF2">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM28342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="73" mass="7756" checksum="215C4FEA01ABB388" modified="2014-04-16" version="1">MNDGKIVLARIPNPNAGPAFYSTASEVATMELTRDVLQIPGPRIFDWSATSNNAVGSEYIIMEEASGTQLGVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2024-10-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>W6QFW2</accession>
    <name>W6QFW2_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S01g002353</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QFW2"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM28542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="58" mass="6124" checksum="E9D8AF4ECA4662F9" modified="2014-04-16" version="1">MKLSQLGFACGDAAGQRRRVNDGMGLSVRKELCEDGMVGNVWSSHGVSIILGSNACKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W6QFW7</accession>
    <name>W6QFW7_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PROQFM164_S01g002358</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QFW7"/>
    <dbReference type="STRING" id="1365484.W6QFW7"/>
    <dbReference type="OMA" id="AYIHAIW"/>
    <dbReference type="OrthoDB" id="9986881at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000088">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF49">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="119"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="148"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="178"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="212"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="285"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="324"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="364"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="391"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="422"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="452"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="50"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM28547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="494" mass="54271" checksum="AD5C5AEC70FEC676" modified="2014-04-16" version="1">MPRIWSKGSFVIQVEPEKDPASLDPAYLVKWDQDDVFNPQNWTPRYKWWVTFQLGMLALAGSLGSSITTPADDTIARYTGVSSEAAVLDVSLYLNASLGFVFGPIIWAPLSEIWGRRVSILPAVFCLALFSIGTGVSRDAASVFVTRFFAGFFGSAPISNVTAALGDIWSKETRGTAVSLYAVAVNGGPALGPVIGAAILLNPNMGWRWTAYIHAIWVFVIFTLTFFCLPEVYPLVLLKRKAQQLRKDTNDSRYYHPHEHLKLDVKSVVTKQLARPLRMLVTEPIVTCIAFYASFVYGVMYLTLEVFPIAFQQSRGWNRVVGSLPFLGLLIGVISSVGLNIWNQYRYNQISKEANGKAVPEARLPPMAFGAVFFVVGLFWFAWTAEPPHHWILPCLAAVFIGIGFNCIFQQCLNFLIDVYKLYAASSTAAVTFLRSLLAAGLPLAAKPMIRALGIGPAVSIIGAVAAALLPVPFLFMKYGPKLRGLSKLAPEDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2024-10-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W6QGJ9</accession>
    <name>W6QGJ9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S03</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S03g001828</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM35101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QGJ9"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM35101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="218" mass="24496" checksum="6AA85A69CA2E19DA" modified="2014-04-16" version="1">MPTPSKLKIESTSSKELSPPSRFPTCSSASLEIVGNTQKARVTTKMIHSSIAFPIGIRGIIIKKTWPSPTTIPNTAFSLPLGSMGNVIKKPLVTASDIHEMFVSPFENHVSHHEEGGELMQKMVSQEDDRFRTAISLWAHLCHPVHVQVDQYGERQHISIIHLLNWFIALPHVRSFFAYLTSCLAETCIPSITPKFIQNGQITFYHSQDHSNHHNHNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>W6QGV4</accession>
    <name>W6QGV4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Galactokinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">GAL1</name>
        <name evidence="12" type="ORF">PROQFM164_S01g002643</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GHMP kinase family. GalK subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QGV4"/>
    <dbReference type="STRING" id="1365484.W6QGV4"/>
    <dbReference type="OMA" id="GFHDTYF"/>
    <dbReference type="OrthoDB" id="187738at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004335">
        <property type="term" value="F:galactokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006012">
        <property type="term" value="P:galactose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000411">
        <property type="term" value="P:positive regulation of transcription by galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1440.340:FF:000003">
        <property type="entry name" value="GAL1p Galactokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000056">
        <property type="entry name" value="GAL1p Galactokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.3170:FF:000002">
        <property type="entry name" value="Galactokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000705">
        <property type="entry name" value="Galactokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019741">
        <property type="entry name" value="Galactokinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019539">
        <property type="entry name" value="GalKase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006206">
        <property type="entry name" value="Mevalonate/galactokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00131">
        <property type="entry name" value="gal_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10457:SF7">
        <property type="entry name" value="GALACTOKINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10457">
        <property type="entry name" value="MEVALONATE KINASE/GALACTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10509">
        <property type="entry name" value="GalKase_gal_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000530">
        <property type="entry name" value="Galactokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00473">
        <property type="entry name" value="GALCTOKINASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00959">
        <property type="entry name" value="MEVGALKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="GHMP Kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00106">
        <property type="entry name" value="GALACTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0299">Galactose metabolism</keyword>
    <keyword evidence="12" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="4" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="6" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Galactokinase N-terminal" evidence="11">
        <location>
            <begin position="42"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP kinase N-terminal" evidence="9">
        <location>
            <begin position="142"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP kinase C-terminal" evidence="10">
        <location>
            <begin position="408"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF10509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDM28832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="524" mass="57764" checksum="E5D4B4589A11FCA5" modified="2014-04-16" version="1">MSPQQELVPQTESIAEVYATDDASLTSVAPEHQKRWTNLITQFNKTYNHRPDFVARSPGRVNIIGEHIDYSLYDVLPTAVSVDVIMAVKVVTASAEGTTITIANVSPEKFPTREFSVPHDKDVEIDPKKHEWVNYFRAGLSGALKFLRKEKPDGSLVPASMQILVDGNVPPGGGISSSAAFVCASALAVLKANNHNVSKQDLLDLAVVSERAVGVYSGGMDQAASIFSKRGYLLYTQFFPRFNVQHVPIPTSSDEITFLMAQSFVTSNKADTAPRHYNLRVAECTLAAVILAKHHGVTLPKDNSSLGYSLRNFHNELMAKEGRVQDPLEYQIDSVIQTTMNVFTQEEGYTREEMAQLLGITVAELESTFLSAFPVQAERFLLRQRALHCFKEARRVLDFKACLTKATQLDEKRIHYLGQLLNESQESCATAYDCSAPEVDEICAIARRAGTWGSRLTGAGWGGCTVHMLPQGKVEAVTAALRDEYYLKKFPDISKEKLEEAMVISKPSNGSFLIAGAAIDRIPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W6QH52</accession>
    <name>W6QH52_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S03</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S03g000253</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QH52"/>
    <dbReference type="OMA" id="MPHKVNQ"/>
    <dbReference type="OrthoDB" id="4361146at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM33529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="62" mass="7085" checksum="2A99FFDC7605730B" modified="2014-04-16" version="1">MPHKVNDSNSTLASRGSNNDQVVATEVRTTNPVRKPPVIVHNKGGRIYDETRPSDWDKQRWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W6QHN5</accession>
    <name>W6QHN5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S03</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S03g000433</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QHN5"/>
    <dbReference type="OrthoDB" id="2976890at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM33709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="62" mass="7109" checksum="60632D2B2BB58302" modified="2014-04-16" version="1">MQELLNVSIKRYMKYYTFIVASDLHYNALVLDNRVSRALLLNEIGEENASKDILQTLLGGLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W6QHT8</accession>
    <name>W6QHT8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Oligopeptide transporter OPT superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PROQFM164_S04g000452</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QHT8"/>
    <dbReference type="OMA" id="YMHIPPR"/>
    <dbReference type="OrthoDB" id="9986677at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004648">
        <property type="entry name" value="Oligpept_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22601">
        <property type="entry name" value="ISP4 LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="260"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="332"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="475"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="502"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="664"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="706"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="741"/>
            <end position="764"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDM35571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="789" mass="89896" checksum="60E05E2E55520CE6" modified="2014-04-16" version="1">MFAALKRKRLEETPTEVEIEQEIMGSEGSEFSKDPKVAETAVDEENLHFKGESAAIEQEIHDNPEIAALPLPVRHLINLTDDPSLPTITFRYFVLAIIFVVPGAFLSQMSHFRTTTAPYSIFFVQIACHYAGHFMARVLPDWRIGLPGTRFSFSLNPAPWSIKEHVLVTLTAASGATYNLGYAPIVLAELWYGTRINPAVAIFFMLSIVWIGYSFAALARQLLLPDPEYIWPQALMQTTLFETFRKTDNSSALARRQMKVFFFALLGMTMWQFLPEYVFPFTSSLAFLCWVAPRNPVANFIGSGIGGMGFLNLSLDWSNVNWNGSSIMTTPYWTQVILFLAFAFNCWVLLPAAKWGSLGSFKHGLMSNNLFLSNGTEYPTLDVLTPDYHLNVTAYEEYGPMYMGLQNVWATFFDYAKLPAAVTWILTFGYAQISGNIRRIWSSRNAEKSTKNDSIHHQYHDRLNVIQRQYKEIPWWWYGILFSVAFVILIIFFALGHLFIPIWTLFVALSSAAILVIPFAWLYAISNYQLETGSFNELMYGYMVHTKAGEAHQHPCGPSVYGAIAGDAWYRAQYMLQDQKIGHYMHIPPRAVFFSQIFGTCMGVPINYAVMRWIMDTKGDYLTGKKTDPLNQWTGQSLRTSNTMGVQYAVLGPKRLFAETEMTVLPWSFLVGAVIPPILFCFHRFFPRLRIDLWNVSIFFGGLAMFYGNISTGYTSAIIGGYIVMYWAYRRHFEVWKRYNYLIAAAFDAGFNLNMLLVFFFFGAGKQVSMPKWWGNNATSVERCFALDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W6QI75</accession>
    <name>W6QI75_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PROQFM164_S01g003079</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CSC1 (TC 1.A.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QI75"/>
    <dbReference type="OMA" id="DPTQVIW"/>
    <dbReference type="OrthoDB" id="1076608at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005227">
        <property type="term" value="F:calcium-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045122">
        <property type="entry name" value="Csc1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003864">
        <property type="entry name" value="CSC1/OSCA1-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027815">
        <property type="entry name" value="CSC1/OSCA1-like_cyt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032880">
        <property type="entry name" value="CSC1/OSCA1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022257">
        <property type="entry name" value="PHM7_ext"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018:SF26">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G10920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018">
        <property type="entry name" value="PROBABLE MEMBRANE PROTEIN DUF221-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14703">
        <property type="entry name" value="PHM7_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12621">
        <property type="entry name" value="PHM7_ext"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02714">
        <property type="entry name" value="RSN1_7TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13967">
        <property type="entry name" value="RSN1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="25"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="409"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="454"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="501"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="549"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="596"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="624"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="663"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="690"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like N-terminal transmembrane" evidence="11">
        <location>
            <begin position="28"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like cytosolic" evidence="12">
        <location>
            <begin position="201"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like 7TM region" evidence="9">
        <location>
            <begin position="410"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="domain" description="10TM putative phosphate transporter extracellular tail" evidence="10">
        <location>
            <begin position="802"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="746"/>
            <end position="774"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF13967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF14703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDM29267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="902" mass="100606" checksum="FC7BA18F343F085B" modified="2014-04-16" version="1">MAHDAVHWLAARDTSDDPQDTTPTLSGLLTTLIPALVSFVVMVLLFIILRKSNRRMYMPRTYIGYLRPWQRTPDSPTGSWNWIKAMYQLPDTYVLQHHSMDAYLMLRFLKLCSVMLFVGCCITFPILWPVNATGGGGKIQLNLLSISNIDETQYGRYYAHCFLAWIYVSFIFFMITREHLFYINLRQAYLFSPANASRISSRTVLFTAVTQDLLNKEKLRTMFGRDKVKNVWIATDTKELEEKVKDRDAAAMKLEGAETKLIVLANKTRSKALKKKGSAENPETDIGDGQFDDESGSVAARWVEAKKRPTHRLTMLIGKKVDTINWARSEIERLSPEIEELQAQHRAGETKLVSSVFVEFYHQSDAQSSFQSVAHNLPLHMSPRYIGLDPTQVIWSNLRIKWWERLGRYAATMSFVCAMIIFWAIPTAVVGAISNIDSLTKIVPFLKFIDSVPSWIKGVITGLLPTVMMAVLLALVPIILRLMAKFGGAPSLPAVELTVQNWFFAFQVVQVFLVVTVASSATSVVSSIIDKPSSAASLLAQKIPTASNFYISYIILQGLSFSAGALLQIVGLILGKILGRLLDSTPRKMYTRWSSLAGLGWGTVYPAFTLLTVVAIVYSCIAPLVMGFGTIGLYLFYFAYRYNLLYVSNSTIDTQGRCYTRALQQLTVGCYLSMVCLIGLFAIGTGANTMALGPLILMIIFLIFVILFHLSMNSAMEPLLNYLPKNLEAEEEGLLAAEKANISTLNENSKTDDMSGPGGSISASRDSGVANVDNSLGSVDSAEKGLTEKSPPAPKPNFLTKFLRPDLYHNYHQLRKLVPSSSEIPTYPAEVERDAYCHPAVSSHPPLLWIPRDPLGVSAQEVAHTSRVIPITDEDAYLDENCKIQWNEEKGEPPIYEEKVTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W6QIM6</accession>
    <name>W6QIM6_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Amino acid/polyamine transporter I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PROQFM164_S03g000788</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QIM6"/>
    <dbReference type="STRING" id="1365484.W6QIM6"/>
    <dbReference type="OMA" id="WVFTHFT"/>
    <dbReference type="OrthoDB" id="10054429at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF10">
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            <end position="50"/>
        </location>
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            <end position="85"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="7">
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            <end position="172"/>
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        <location>
            <begin position="184"/>
            <end position="205"/>
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    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="225"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="265"/>
            <end position="292"/>
        </location>
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        <location>
            <begin position="319"/>
            <end position="338"/>
        </location>
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            <end position="389"/>
        </location>
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            <begin position="395"/>
            <end position="418"/>
        </location>
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        </location>
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        </location>
    </feature>
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    </feature>
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        <source>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="521" mass="56139" checksum="CC4DBFFD62607083" modified="2014-04-16" version="1">MATIHDDDELLLARIGYKQELRREFSKWSTVSYAISILGVLGSVPATFGAPLSAGGPATAVWCWLIGSCMAMCIGSSVAELVSAYPTAGGMYFVTKQVVPPDQVPIFSWIQGWCNLLGQTAGVSSVAYTVSQMLLACVSMNSDLVDGKYSYAPTALETVLVSIAVLCILGVICSLTTKSLHRIILWFAPINIGATICICIALLTLTPNLQPASWVFGHFTDGSGWGSKVFSFFLGFLSVAWTMTDYDGTTHMSEETHDAAVRGPVAIQTAVLVSGALGWLLTVSMCFCLTDFEGILTSPTGLPAAQIFLNAGGKRGGTVMWAFAILVQFFTGCSAMLADTRMAYAFARDDALPFSKYLSKVNPRTHTPVNAVWFVVFFSVGLNCIAIGSTQTATAIFNITAPALDISYVSVILAHQLYKSKVKFIEGPFTLGRWGTSINYIAVVWVLFISTILFFPPQLPVTPANMNYAICVGGFIAAFALIWWWVAARGKYTGPQTNDIIREIPTEDDGDDSEESGEITV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W6QIQ9</accession>
    <name>W6QIQ9_PENRF</name>
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        <submittedName>
            <fullName evidence="3">WW/Rsp5/WWP</fullName>
        </submittedName>
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    <gene>
        <name evidence="3" type="ORF">PROQFM164_S04g000767</name>
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        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
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                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">FM164</strain>
        </source>
    </reference>
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    </dbReference>
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        </location>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
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            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43130:SF3">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="DJ-1/PfpI" evidence="2">
        <location>
            <begin position="11"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM29737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="202" mass="21804" checksum="4300904AD44812AB" modified="2014-04-16" version="1">MSLRSSNKYYKVGVLLFPGADILDFAGPIEVLSHVSHNRNPENPKRMFEITTVACSPTIRAANLLTVHADLLLPDAIDRISDFHILVIPGGPPSVLQPLLENSTPELDLIRKFVALPVALLSGTRILLSICTGAFLLGAAGILGGMTVTTHHHALDRLRDICAQFNAPGDHTTTVLHRRYIDGGLLNETVFDSSRPEGSAQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W6QJY8</accession>
    <name>W6QJY8_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein FYV10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Protein fyv10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PROQFM164_S05g000134</name>
    </gene>
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        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the proteasome-dependent degradation of fructose-1,6-bisphosphatase.</text>
    </comment>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1365484.W6QJY8"/>
    <dbReference type="OMA" id="KMILWAQ"/>
    <dbReference type="OrthoDB" id="2415936at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013144">
        <property type="entry name" value="CRA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024964">
        <property type="entry name" value="CTLH/CRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006595">
        <property type="entry name" value="CTLH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050618">
        <property type="entry name" value="Ubq-SigPath_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12864">
        <property type="entry name" value="RAN BINDING PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10607">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08513">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00757">
        <property type="entry name" value="CRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00668">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00667">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50897">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CTLH" evidence="4">
        <location>
            <begin position="68"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDM36301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="266" mass="29524" checksum="503C6219A8311616" modified="2014-04-16" version="1">MSANVMSRTSSTATPTWHHFERKLEEVKPSKTDINYLVMDYLITNGYPAAAKKFAVEANIQLRTDLEAIQERVEIRTAIHSGDIQAAVEKINELNPQILDEDPSLHFSLLRLQLVELIRTCMDTPGSDITPALDFATAQLAPRAPTNPQFLADLERTLALLIFPSDKLAPSLASLLDPALRKEIATRVNEAILQNQGARKEARLRNLVKTRAYAELKAREAKKDIPDTLDIGLVGDSHDNSNSNDLATNIRDTLMSNNSDIDPMIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W6QK98</accession>
    <name>W6QK98_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Translation machinery-associated protein 22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">tma22</name>
        <name evidence="10" type="ORF">PROQFM164_S02g000156</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM164</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3 8">Interacts with the 40S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="8">The SUI1 domain may be involved in RNA binding.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the DENR family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QK98"/>
    <dbReference type="STRING" id="1365484.W6QK98"/>
    <dbReference type="OMA" id="EVFEIDM"/>
    <dbReference type="OrthoDB" id="277199at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001731">
        <property type="term" value="P:formation of translation preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002188">
        <property type="term" value="P:translation reinitiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11607">
        <property type="entry name" value="DENR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.780.10:FF:000014">
        <property type="entry name" value="Translation machinery-associated protein 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.780.10">
        <property type="entry name" value="SUI1-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050318">
        <property type="entry name" value="DENR/SUI1_TIF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046447">
        <property type="entry name" value="DENR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005873">
        <property type="entry name" value="DENR_eukaryotes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048517">
        <property type="entry name" value="DENR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001950">
        <property type="entry name" value="SUI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036877">
        <property type="entry name" value="SUI1_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01159">
        <property type="entry name" value="DRP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12789:SF0">
        <property type="entry name" value="DENSITY-REGULATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12789">
        <property type="entry name" value="DENSITY-REGULATED PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21023">
        <property type="entry name" value="DENR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01253">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55159">
        <property type="entry name" value="eIF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50296">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6 8" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="SUI1" evidence="9">
        <location>
            <begin position="100"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDM30007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="195" mass="21445" checksum="207FE2B891F3F5BB" modified="2014-04-16" version="1">MAEVETAPVVQARHVVYCGVCTLPPEYCEFGGTAKKCEEWLKDNESDLWDKLYSEDALNANLSTLSVSAQERAAKDAAKKEAKAAASEARDSERKAASKIQIKRVERNKRKYVTVVIGLEVFGLENKKIAKDLGKKFATGSSVTRSPAGVEEITVQGDVSDDLHDWLLEVHGKKIPASNIELIEDKKKKKSEGPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W6QKC3</accession>
    <name>W6QKC3_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S05g000703</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QKC3"/>
    <dbReference type="STRING" id="1365484.W6QKC3"/>
    <dbReference type="OMA" id="RWRQSIR"/>
    <dbReference type="OrthoDB" id="5288142at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="479"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="147"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="498"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="519"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM36870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="857" mass="95208" checksum="0BFEAA8411549F13" modified="2014-04-16" version="1">MAYNAIAQLDHEVASVSSASASPCPSPTHKHAFEQLPLDTDHIGGGSHLETAKTTENPTFSRLGSMIRSMTAASYDVVEDDDYDADPSPEERANSLRIPPLNTTARNPSPERPIHSACSEVPVPLSHPTPDLQSIQGAYKGNVTRLEQSAEQLSSSSADIESEIRRMDQEQKRRSVSSASNSIHRTGAFSPVATISSAHGSIASPGRQRSVSGARLAQLAEPAHEEEPEVDEFPGLPDLPPAQPLFNTQSDYYYDQYVPQGVPAEPELQRRASVASFDTYQQARTLFTDFDGVHFTPLEPGRQVSLEQPPLARNPDHYKNPRAGENMVFYPAPVPRMLNLPPKLSRRENIDRDKRRTQIAGAIAAQDRKSTVGLPDAVLGDSRDSHNDKRKSTVPPHLRASVFFDQPSTSLQVEVKQQSAVATLESILDASANAPVSAFTDHPYAGQVGAFIYNTSKRKTLTKDPTVHKTNRLSRAIFGQSYNTNNVEEDEVPATLRHGSDDSDRNDDEHGHERGPEGTDGESEESEDEGSDDADIMDYVGPPNTLIAELELRKHELKHRRRTIVPVPFRGMRSTLLEMDDMVQKQSDNRRQRPVALAWEGRDDDDDVPLAMLYPEKTNIEEDRPLGLLAMRHQEENEPLSSRRARLRGEPIPRPEQRPVTMYAEPPAHVPEPAAESEDETEVETLAERVQRLKGHKRSESKFASDLMAEIDTRAGVAPKEPEEVPVPIEEETLAQRRSRLRKEAAAAPAAPKNPRMRRSMAALTQGRPSHLSRQSSYDVFNQRPVTMSQFGNRMSMQQFPTQMRYPPPVGYPMAQQYGYPINPATMGMNGVGYAPNMVPPGPVKTEVIDRWRQSIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W6QKE9</accession>
    <name>W6QKE9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BolA-like protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">Bola2</name>
        <name evidence="2" type="ORF">PROQFM164_S05g000738</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BolA/IbaG family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QKE9"/>
    <dbReference type="STRING" id="1365484.W6QKE9"/>
    <dbReference type="OMA" id="VHAFSQK"/>
    <dbReference type="OrthoDB" id="4983at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045115">
        <property type="entry name" value="BOL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002634">
        <property type="entry name" value="BolA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036065">
        <property type="entry name" value="BolA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12735:SF27">
        <property type="entry name" value="BOLA-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12735">
        <property type="entry name" value="BOLA-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01722">
        <property type="entry name" value="BolA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003113">
        <property type="entry name" value="BolA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82657">
        <property type="entry name" value="BolA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM36905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="88" mass="9699" checksum="FDFB01E4FADAA96F" modified="2014-04-16" version="1">MADTFGITTDSLKNKLTEALQAQHVEVEDLSGGCGQAFQAVIVSPQFESKTMLARHRLVNSALKAEIAAIHAWTPKCYTPEQWQALQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W6QKX7</accession>
    <name>W6QKX7_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Alcohol dehydrogenase superfamily, zinc-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PROQFM164_S03g001551</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QKX7"/>
    <dbReference type="STRING" id="1365484.W6QKX7"/>
    <dbReference type="OMA" id="KCSSRCA"/>
    <dbReference type="OrthoDB" id="442947at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08284">
        <property type="entry name" value="FDH_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42813:SF6">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42813">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="7">
        <location>
            <begin position="25"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="6">
        <location>
            <begin position="181"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM34824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="350" mass="38511" checksum="86392A619CCF1CD4" modified="2014-04-16" version="1">MQAVVFKGPSKVVIEQKPIPKIQDPTDVILKVRYTALCGSELHVFRGHQKSGIEFVMGHEFTGEVVELGSDIKNFQKGDRVVSPFTTSCGKCFYCKRGFSSRCAQCQLFGTVALDGGQAEYVRIPLADSTLVKVPASIDEKKLVLMADIFPTGYFASLNAFSGLTPEEIHESTLLLFGCGPVGICALIGALDYKPKTLIAIDSVPSRLALAQSLGAEPWNFKEDGEGLRQRVKDLTDGRGADIVIEVVGHSDALRLGFDLLRPWGRISSVGVHNQEIPWTGNEAYAKNLSLQMGRCPVRSIFGPALDLFEKKQDILNFMCHDIRPLSQAVQAYDDFDNMRAHKVIFEADK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W6QLH7</accession>
    <name>W6QLH7_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein kinase-like domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S06g000241</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792020">
        <property type="protein sequence ID" value="CDM37280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QLH7"/>
    <dbReference type="OrthoDB" id="4177236at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05120">
        <property type="entry name" value="APH_ChoK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF48">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="118"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM37280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="408" mass="46185" checksum="1C896E6EE69D5D59" modified="2014-04-16" version="1">MDNELQSIIELPTIADIEASTDVLSIRTNAIKVVRVKERFAVKIGYSIPPLEAENMKFVAANSKVPVPKVHANFIDPETQKRYVVMDFVPGTDLQKLLPSLTPTEKTTISQRIRQAVNELRTIPSPGHFGNLNCTPYTDGPEADESTSTDVLSIRTNAIKVVRVKERFAVKIGYSIPPLEAENVKFVAANSKVPVPKVHANFIDPETQKRYVVMDFVPGTDLQKLLPSLTPTEKTTISQRIRQAINELRAIPSPGYFGNLNGTPYIDGVLSTPDNNPIISGPFKDQKQMNQGILERLGQMQSPHYIRLLKEMVNRTLKNHRIVFTHGDLQPKNIIVERKGVCNNGDADFKVTLIDWNLSGWYPEFWDFCNSTLYCQMKPDWLELIPDIFDQYPVEYLMMQVVYSSVFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W6QMU6</accession>
    <name>W6QMU6_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Hsp90 chaperone protein kinase-targeting subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PROQFM164_S04g000375</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CDC37 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QMU6"/>
    <dbReference type="STRING" id="1365484.W6QMU6"/>
    <dbReference type="OMA" id="NYSKWDQ"/>
    <dbReference type="OrthoDB" id="440202at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031072">
        <property type="term" value="F:heat shock protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050821">
        <property type="term" value="P:protein stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.610:FF:000002">
        <property type="entry name" value="Hsp90 co-chaperone Cdc37, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.610">
        <property type="entry name" value="Cdc37, Hsp90 binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004918">
        <property type="entry name" value="Cdc37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013873">
        <property type="entry name" value="Cdc37_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013874">
        <property type="entry name" value="Cdc37_Hsp90-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038189">
        <property type="entry name" value="Cdc37_Hsp90-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013855">
        <property type="entry name" value="Cdc37_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12800">
        <property type="entry name" value="CDC37-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12800:SF4">
        <property type="entry name" value="HSP90 CO-CHAPERONE CDC37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08564">
        <property type="entry name" value="CDC37_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08565">
        <property type="entry name" value="CDC37_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03234">
        <property type="entry name" value="CDC37_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01069">
        <property type="entry name" value="CDC37_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01070">
        <property type="entry name" value="CDC37_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01071">
        <property type="entry name" value="CDC37_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101391">
        <property type="entry name" value="Hsp90 co-chaperone CDC37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cdc37 N-terminal" evidence="9">
        <location>
            <begin position="2"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="Cdc37 Hsp90 binding" evidence="8">
        <location>
            <begin position="190"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="Cdc37 C-terminal" evidence="7">
        <location>
            <begin position="379"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="181"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="463"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="195"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDM35494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="482" mass="53313" checksum="ABCA99B3E9C491A6" modified="2014-04-16" version="1">MVLDYSKWDALELSDDSDVEVHPNVDKRSFIRAKQAQIHQQREQRRHEIKTLKYERIINDGLLSRIDKLLESLKKHEDSSASPDEFIFTTIMEFASNPAEDQAPTPPEGVYTHEPEQPKFSQMMSSLVDQVKKEIGDSKPDNLFKAYIQGVNGHLEKIQGLQKELFAKLAQLEKEEGAKITSDQLHEGFNQSHVAKADEKKKAAAKPKESSVELLNPGAGSSAAKADDEGDDDDPADIEISPLAKKFAQLKPGDYKACLQFISANPEIVAEKETDGLLVEAFNSQLKGQDAYARQCVHQGLLLQYCRSLGRDGIQLFFTRITTKDHRASTLFLNDVNDTYARIKSRSAELSKDGSASNDPAGVEQIQLHAVDPNTKITINIPAANSEDPTEIEVRKIFDAFPEDLQKALATESLDEVNKVLGKMSVEEAEVVVEQLGNGGMLSLEEGIVDATTAEGQKKLKELEEEGKQEVGEPGGDITELD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W6QMW2</accession>
    <name>W6QMW2_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S07g000088</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
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            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792021">
        <property type="protein sequence ID" value="CDM37740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QMW2"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM37740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="62" mass="7153" checksum="9474D0275DB94F7B" modified="2014-04-16" version="1">MNLIYGTCYPQVVERVQSCKPRACMPRPTGFDEEDQGYWKAHRATLLPAPNNEQLFGWGFHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W6QNI9</accession>
    <name>W6QNI9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S13g000006</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792027">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QNI9"/>
    <dbReference type="STRING" id="1365484.W6QNI9"/>
    <dbReference type="OrthoDB" id="2890403at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="389"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="390"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="402"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM38483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="426" mass="43271" checksum="8E5897E8D1CCBF33" modified="2014-04-16" version="1">MSTDGVKISNENTTNGASGEPMGGMSGSYSALARFADTTKYIFAWVSRGAIDVTENAWMGSGYTNVQNRTNGRNVAISLFSDKYTKVGAQATSEVGSEDGDSQVNWVNSGSNDCSNAHAAAFGSSNALVTWEEISNLTCDFIAMGCRGTFAGTYFQQVDSTGSKVGQAFSADDVYVAGDMVTMSDGRICWPYVNMTWDLSQSIDDSSSSATGKKMSIACVGRDGATDSPTTTAASVTTSATAKVAITEGASAVIKAASSETTVKAPTQITEAASSATTIKAISQTTEPAAKATSGSVAAIGSGFGNPSSSSVIEVAKAVTSSAASGIVDVIASGPDSELPAATAIYTPDTPSGPSGVPAVSEVPTDAQSAIPSSVVSAIPSGTPTGIARGHGRKHGHGWGHHGTEHHSSGHHSAKYDEVPESEPQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W6QNJ8</accession>
    <name>W6QNJ8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S08g000011</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792022">
        <property type="protein sequence ID" value="CDM37960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QNJ8"/>
    <dbReference type="STRING" id="1365484.W6QNJ8"/>
    <dbReference type="OrthoDB" id="4187154at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM37960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="150" mass="16563" checksum="56B36AB106FFD567" modified="2014-04-16" version="1">MKRPVDLGHCDFELSPLRLHFSATAYFTEAATGTGPSLGHTTISFSQWIDLRTLWVSQAPQLELRLFVSFDPMIKAAEPAFATELVREIGLPEVWSGPGAHSMPGFGEYTSRIYELQYHATARELPRTKVPGAIALRPPETVSIGRAPEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W6QP69</accession>
    <name>W6QP69_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PROQFM164_S02g001537</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the wax synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QP69"/>
    <dbReference type="STRING" id="1365484.W6QP69"/>
    <dbReference type="OMA" id="PCMIWIV"/>
    <dbReference type="OrthoDB" id="1077582at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044851">
        <property type="entry name" value="Wax_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032805">
        <property type="entry name" value="Wax_synthase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31595">
        <property type="entry name" value="LONG-CHAIN-ALCOHOL O-FATTY-ACYLTRANSFERASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31595:SF27">
        <property type="entry name" value="WAX SYNTHASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13813">
        <property type="entry name" value="MBOAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="63"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="144"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="282"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="311"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="353"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="382"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="Wax synthase" evidence="8">
        <location>
            <begin position="231"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM31387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="416" mass="47166" checksum="31A68598D2C88779" modified="2014-04-16" version="1">MDRYQSNGRLLAFFVLQGLIPSVVLITTPKRSAIRYLSIPCMIWIVLHAMYPIQGRGFTSTHLLASCATFVLTALDLLLINPQAGRDFVDANGNIKSFIPRLVEAVRLITFTRAVNTPRQVKNVPPFPAYYTKRDPKVIPRGRFLVRETAIAVWQFLVLDICTGLILKQAMNDQDEGKTSSSGILGLEWITKTLIQVAIAWLVVCRILISFYYRVASIIFVGLGDSPLNSPPIIGRTADVYTLRNFWGKFWHQMLRLPLTSTSNFLARDVLRLPRSSLVERYTNVFIVFFFSGLIHVVLDSLRDVSPRDPATMSFFLSFVIGYIIEDGVQALWKRTRGSRDNIGLPTWWQKTIGYCWVLTWLGVTSPWYFRTKMLKPEQHMVWVPFSVAGLISPLLLNSIVIGGGLVLKFVFEGEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>W6QPE7</accession>
    <name>W6QPE7_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP-dependent RNA helicase DBP10</fullName>
            <ecNumber evidence="4">3.6.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">ATP-dependent RNA helicase dbp10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="primary">dbp10</name>
        <name evidence="21" type="ORF">PROQFM164_S02g001617</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DEAD box helicase family. DDX54/DBP10 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="4"/>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QPE7"/>
    <dbReference type="STRING" id="1365484.W6QPE7"/>
    <dbReference type="OMA" id="EDQFGMM"/>
    <dbReference type="OrthoDB" id="10261375at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17959">
        <property type="entry name" value="DEADc_DDX54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000865">
        <property type="entry name" value="ATP-dependent RNA helicase DDX54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012541">
        <property type="entry name" value="DBP10_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033517">
        <property type="entry name" value="DDX54/DBP10_DEAD-box_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF8">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08147">
        <property type="entry name" value="DBP10CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01123">
        <property type="entry name" value="DBP10CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11 21" id="KW-0347">Helicase</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="13" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="8" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="20">
        <location>
            <begin position="85"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="18">
        <location>
            <begin position="116"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="19">
        <location>
            <begin position="354"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="339"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="808"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="16">
        <location>
            <begin position="85"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="825"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="841"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="884"/>
            <end position="893"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00021760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="CDM31467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="913" mass="101410" checksum="9183C2229F73C978" modified="2014-04-16" version="1">MAPRAASPAESEVEFDITKSLFEHDSDSDDGAKPPPKKKPQKPDTHQDLDFLNEDDGDAAFIANSQASANRKGANLKGRTVKKGGGFQAMGLSMSLLKAITRKGFSVPTPIQRKTIPMIMDDKDVVGMARTGSGKTASFVIPMIEKLKSHSTSFGARALIMSPSRELALQTMKVVKEMGKGTNLTSVLLIGGDSLEDQFGMMANNPDIIIATPGRFLHLKVEMDMDLSSIKYVVFDEADRLFEMGFAAQLTEILHGLPTNRQTLLFSATLPKSLVEFARAGLQEPSLIRLDIENKVSPDLQNAFFAVKSADKEGALLHILHNIIKMPTGETYIGGRLRQEAENPTRKRKRSDVRLPSGFKESPTEHSTIVFAATKHHVDYLYSLLTEAGFATSYAYGSLDQTARNHHVQNFRSGISNILVVTDVAARGIDIPVLANVINYDFPSQPKIFIHRVGRTARAGQKGWSYSLVRDKDAPYLLDLQLFLGRRLVLGRQYGTEVNFAEDVVVGTLPREAISRTCEWVQKVLDDDIDIYGQKGVSQKGEKLYLRTRNSASAESAKRAKDVVSSDHWAEIHPLFNDATTEREVERESMLARIGGYRPHETIFEANNRRGGKVADNEAVDTIRRLRTSVENKRKRADAKAEAELAALGMPTPGPDGQVEDEDIPEHAGENMSDASDDDLEVTFSAYNSKSKQGEKKDAAAAFQNPDYFMGYTPQHNDMAEDKAYGVHSGTNSNFASDSRNATMDLNGDEGKRGFGEARSIMRWDKRHKKYVARQNDEDGSKGSRLVRGESGAKIAASFRSGRFQAWKKGKRVDRMPRVGEAETPNMNNVNSRMSSGRFRHSQDRAPKRADPLRGDYDKMKKKNDAARERQHDKLGGAAYGGKSELRSTEDIRKARKQVQQRRDKNARPSKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W6QPL4</accession>
    <name>W6QPL4_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Xaa-Pro aminopeptidase</fullName>
            <ecNumber evidence="5">3.4.11.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Aminoacylproline aminopeptidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Prolidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PROQFM164_S11g000043</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of any N-terminal amino acid, including proline, that is linked to proline, even from a dipeptide or tripeptide.</text>
            <dbReference type="EC" id="3.4.11.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the peptidase M24B family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.9" evidence="5"/>
    <dbReference type="EMBL" id="HG792025">
        <property type="protein sequence ID" value="CDM38340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QPL4"/>
    <dbReference type="STRING" id="1365484.W6QPL4"/>
    <dbReference type="OMA" id="YDRNNEP"/>
    <dbReference type="OrthoDB" id="10261878at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01087">
        <property type="entry name" value="Prolidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001131">
        <property type="entry name" value="Peptidase_M24B_aminopep-P_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052433">
        <property type="entry name" value="X-Pro_dipept-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43226">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43226:SF3">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE AN0832-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00491">
        <property type="entry name" value="PROLINE_PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 16" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="8 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="7" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M24" evidence="15">
        <location>
            <begin position="83"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00032413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CDM38340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="379" mass="42321" checksum="665768DA1C123499" modified="2014-04-16" version="1">MGPTLSREDAQDRYDVDHVRYQSSLKYELQAWLDKRKQGSELYLIHDSEKPEHLPKDLPLNVEQLGPAMDAARGVKDEYEIRMIRQANKVSGLAHRRILENIQTMSNESQIEGSFLNTCISHGARNQAYQIIAASGPNAAVLHYDRNNEPLSKKPLVCLDAGAEWNCYASDVTRTFPLTGEWPSDYVRDIYKLVERMQEECIQLIRKGTRYLSLHDLAHDIAIEGLLALGVLKNGTNLEIRQSGASKVFFPHGLGHHVGLEVHDVSERSIMALHQGFDQLQYRPILDSTCLSPCTLSAPLLEEGMVVTVEPGLYFSSLALANARHQPSARYIDFDVAEKYVHIGGVRIGDDILVTATGYENLTTAPKGEEMLAIIRGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W6QPT3</accession>
    <name>W6QPT3_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">L-dopachrome isomerase</fullName>
            <ecNumber evidence="9">5.3.2.1</ecNumber>
            <ecNumber evidence="8">5.3.3.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">L-dopachrome tautomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Phenylpyruvate tautomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PROQFM164_S08g000057</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>3-phenylpyruvate = enol-phenylpyruvate</text>
            <dbReference type="Rhea" id="RHEA:17097"/>
            <dbReference type="ChEBI" id="CHEBI:16815"/>
            <dbReference type="ChEBI" id="CHEBI:18005"/>
            <dbReference type="EC" id="5.3.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-dopachrome = 5,6-dihydroxyindole-2-carboxylate</text>
            <dbReference type="Rhea" id="RHEA:13041"/>
            <dbReference type="ChEBI" id="CHEBI:16875"/>
            <dbReference type="ChEBI" id="CHEBI:57509"/>
            <dbReference type="EC" id="5.3.3.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MIF family.</text>
    </comment>
    <dbReference type="EC" id="5.3.2.1" evidence="9"/>
    <dbReference type="EC" id="5.3.3.12" evidence="8"/>
    <dbReference type="EMBL" id="HG792022">
        <property type="protein sequence ID" value="CDM38006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QPT3"/>
    <dbReference type="STRING" id="1365484.W6QPT3"/>
    <dbReference type="OMA" id="MMVTIQQ"/>
    <dbReference type="OrthoDB" id="255819at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004167">
        <property type="term" value="F:dopachrome isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050178">
        <property type="term" value="F:phenylpyruvate tautomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.429.10">
        <property type="entry name" value="Macrophage Migration Inhibitory Factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001398">
        <property type="entry name" value="Macrophage_inhib_fac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014347">
        <property type="entry name" value="Tautomerase/MIF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11954">
        <property type="entry name" value="D-DOPACHROME DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11954:SF6">
        <property type="entry name" value="MACROPHAGE MIGRATION INHIBITORY FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01187">
        <property type="entry name" value="MIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55331">
        <property type="entry name" value="Tautomerase/MIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0202">Cytokine</keyword>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="260"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="276"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="322"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="334"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="367"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00036735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00036823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00039086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00041912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00042730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDM38006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="377" mass="41421" checksum="942B71435659DE74" modified="2014-04-16" version="1">MLNDTMGSSKKKPSLPRLTTNIPLLQKPTNASCNTLLPKTLPDASVPPIIMPERPARTSSLFKEDKHDEENIVPVTRFASESMPVYLPQKSVDDSPVTKTKKLYYEDAFTARGSHNSPKDRVTHESVVVVELKTNTKPKDNISKLLSDFAHLLAQVYQRPETSMLVTIDQNADLLFGTTSGSAYLLKVTALSSLIGPLTNLRNTGLIQSIIQEMFGIAPDKGVVIYMPASEDNIATNGTTARSEIDRLERINSSNNSSIFKSLSRSMSRRMKSSSGNSIPISLTSVMSPDVATPTSTSPIAFASDQAPPLRSNQADDKKPLQSPNAERTQQVSSKDEKPERVLKKRESLKSFVNRRLGELGELTTMKPFTTTKGKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W6QQH0</accession>
    <name>W6QQH0_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S02g001913</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QQH0"/>
    <dbReference type="STRING" id="1365484.W6QQH0"/>
    <dbReference type="OrthoDB" id="432234at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM31762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="104" mass="11588" checksum="9339B8CF55435A10" modified="2014-04-16" version="1">MITDVISMVDLAALSTHCKTVRSLARSSTDLVAGLPWDRFYGVIYDEQMRQDQDVSYRDLLRRSGTLTCDDLATPNSKAISSLSDPQFQTSPAIVKLNSLRHVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W6QQI8</accession>
    <name>W6QQI8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Beta-lactamase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S02g001943</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QQI8"/>
    <dbReference type="STRING" id="1365484.W6QQI8"/>
    <dbReference type="OMA" id="CSGWRAK"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07713">
        <property type="entry name" value="DHPS-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041712">
        <property type="entry name" value="DHPS-like_MBL-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052926">
        <property type="entry name" value="Metallo-beta-lactamase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13754">
        <property type="entry name" value="METALLO-BETA-LACTAMASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13754:SF13">
        <property type="entry name" value="METALLO-BETA-LACTAMASE SUPERFAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_3G07630)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="1">
        <location>
            <begin position="96"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM31792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="358" mass="38956" checksum="1CC591C161F1264E" modified="2014-04-16" version="1">MDLHVSHDPFSDSIEMPIHLQEVDSLEAIVIIDNELDPLSPAAPNTVQVSGNLGAIAMGSKHTLTDRGEACKELRLEDVCCAAHGLSIMVTATKGKKKHAILFDAGPEEEAWERNVKRLGPNLSSVEVIQLSHWHRDHSGGLLRAIRMINNAKQAESRSEHLVVDLHPDRPVYRGLALPEHIISLEADPTFEQIGSAGGVVDKRSEPHTVLDDFFLVSGEIPRVTPYETGLKNAVRYDPDENDWFSDEVIIDERSLICNLKGKGLVVFTGCSHAGVVNTTKHAVELTGGTVPVHAVVGGFHLATSDADQIQNTVADLKRLDPAVLMPGHCSGWRAKFAIEKHMPGSLVPCTVGSRITF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W6QQN0</accession>
    <name>W6QQN0_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Delta l-pyrroline-5-carboxylate synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PROQFM164_S02g002003</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM164</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid degradation; 4-aminobutanoate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QQN0"/>
    <dbReference type="STRING" id="1365484.W6QQN0"/>
    <dbReference type="OMA" id="FMMITRK"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004777">
        <property type="term" value="F:succinate-semialdehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009450">
        <property type="term" value="P:gamma-aminobutyric acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07103">
        <property type="entry name" value="ALDH_F5_SSADH_GabD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000023">
        <property type="entry name" value="Succinate-semialdehyde dehydrogenase (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000004">
        <property type="entry name" value="Succinate-semialdehyde dehydrogenase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050740">
        <property type="entry name" value="Aldehyde_DH_Superfamily"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353:SF7">
        <property type="entry name" value="SUCCINATE SEMIALDEHYDE DEHYDROGENASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353">
        <property type="entry name" value="SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="4">
        <location>
            <begin position="27"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDM31852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="499" mass="53535" checksum="B4377DEDF6D52636" modified="2014-04-16" version="1">MATQYQLPFKLADPSLLKFDSIVGDKWVGAKSGKRFEVLDPGTDKAWASCPANAAEDVSAAVENSHAAFEQFRKVNPRQRAKWLLGWYNLTVAARDDLAQIVTYETGKPLAEAYGEIDYSLGFLWWFAGEAERIQGSVSTAAAPNRRLFTIKQPIGVAAALVPWNFPVAMVLRKVGAALAAGCTMVVKPSPETPISALVLAELAHRAGIPAGVLNVLTTDLENTPALSEALCKHPLVKKVTFTGSTRIGKLVAAHCAHGLKKVTLELGGNCPFLVFDDANLDQAVEQLMSLKWRHAGQACITANRIYVQAGVYDRFAALLKERTAAIVVGHGAAANTTMGPLTTPRSLDKASAQVEDARRLGADVILGGNSLTSKPGYFFEPTILSGMTADMAISHEESFAPIAALYRFDTEDQAVKLANDTSMGLASYAFTKNIDRMWRLLENLEAGMIGMNTGNSSAAESPFGGLKESGYGKESGKDVAVNEYLVTKTGTLTIEGQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W6QR44</accession>
    <name>W6QR44_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Swiss Army Knife RNA repair protein HAD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S02g002168</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QR44"/>
    <dbReference type="OMA" id="GKIQNWH"/>
    <dbReference type="OrthoDB" id="5596992at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031428">
        <property type="term" value="C:box C/D methylation guide snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990259">
        <property type="term" value="F:histone H2AQ104 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008649">
        <property type="term" value="F:rRNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000494">
        <property type="term" value="P:box C/D sno(s)RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018812">
        <property type="entry name" value="SAK_HAD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10335:SF23">
        <property type="entry name" value="OB FOLD-CONTAINING PROTEIN, NUCLEIC ACID BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10335">
        <property type="entry name" value="RRNA 2-O-METHYLTRANSFERASE FIBRILLARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10307">
        <property type="entry name" value="HAD_SAK_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Swiss Army Knife RNA repair protein HAD" evidence="2">
        <location>
            <begin position="69"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="442"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="494"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="507"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="542"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="560"/>
            <end position="575"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM32017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="575" mass="63859" checksum="9F94BEC236AD11D4" modified="2014-04-16" version="1">MRSAKAVVSENLARFGSAANMSYSTGSGINRPHTITSLRRWSIVNKELPAVSQIRAIHVYDFDNTLFLSPLPNPQLWHGSSVGFLQTNDSFATGGWWHDPNILAATGKGMEIEEPRKWEGWWNEQILSLVRNSMEQKDALTVLLTGRSEAGFSDIIKRMVASQNLEFDLIGLKPEVGPHGQRFATTMNFKQNFLEDLVFTYEQAAEIRVYEDRVRHVKGFRDFFECLNRDLQNGPSTARMPILAEVIQVTEGSTYLDPVTEASEVQRMVNSHNLTLRNPALNVTKSRSGRLYIKRVVFYTGYLVSPEVSNSMTQKLLAPLLPPGLGESNDLKYMANSILITPRPAPRSILGKVGGLGKKLKWQVTGTGNLDNKIWAARVAPIPATEPYHTENPLPIVVLAVRKGARLIDAGKIQNWHPIPADKAMTFETVVGEKVVLRVEDSGEYRQGEQPLNRSQKRRFQPDDGNVVWPNQNTGSDGPSYGRGNYHSSQRGGGDGRHQYDDSPRGRGAHRGRGRGVGRGRGNNNRGRGRGRGRGEYYQYRSLDDHSTGHDGQHDSKNGHNGGGGAGRGGYSMDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2024-10-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>W6QRA1</accession>
    <name>W6QRA1_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S05g000422</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QRA1"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM36589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="78" mass="9042" checksum="0F74329F1BD5A1D8" modified="2014-04-16" version="1">MAYNFTILTSQSQPVQYRLLWQGLSKKTDKQHNYDLGIEPLPTGHEKSQKHYAPAQLRWLSSPSDGFKPNLYVMPSMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W6QRF3</accession>
    <name>W6QRF3_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pyridoxal phosphate-dependent enzyme, beta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PROQFM164_S05g000472</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20A family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QRF3"/>
    <dbReference type="STRING" id="1365484.W6QRF3"/>
    <dbReference type="OMA" id="MMNGHID"/>
    <dbReference type="OrthoDB" id="10059875at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001261">
        <property type="entry name" value="ArgE/DapE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006058">
        <property type="entry name" value="PRK08206.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42937">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42937:SF1">
        <property type="entry name" value="DIAMINOPROPIONATE AMMONIA-LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="Bacterial exopeptidase dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00758">
        <property type="entry name" value="ARGE_DAPE_CPG2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="3">
        <location>
            <begin position="35"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="4">
        <location>
            <begin position="548"/>
            <end position="635"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDM36639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="737" mass="78246" checksum="E331366F2AFBE0B3" modified="2014-04-16" version="1">MSSRRSIYFNPAAANESSAAPQIEGLTAFHQSFPNYAPTPLVQLPELAAELGISNVLVKDESNRFGLPSFKVLGASWGCFRAIAAQLSLPSTVSLDELSSRAKEASIVLTTASMGNHGRAVAFMARLLGIEARVFVPRSLNQWTRDLIAGEGARVVVVQGDYDQAVQEAVDETRMGQGVLLIQDTAFEGYEDVPAWIVEGYSTMMHEVQSELARLGLSGSVVITPVGVGSLAQAVAKHCKSQNTTISVVAVEPDTAACLSSSLTAGKPVTVRTSSTIMDGMDCGTVSSTAWPDLQSLIDACVTVSSYESHRAVQYLTSKSVAAGPCGGASLAALRRLATSKEGTSLLNKDSVVVLLSTEGAREYPVPRDVSVDDVVELTQTLTQINSSNLTLSVTDGVGETEIANYLAAWFAHRDIEYHWIEKVAERPSIVGVLRGSGGGKSLMFNGHTDTVSLSSYEADPLSGSIGTKNGKEVIFGRGCLDMKGGLAAGLAALAAIKASGRVPRGDIILAAVSDEEDASQGTQDVLEAGWRADAAVLPEPTQGAIFTAHKGFVWVEVDILGVAAHGSDPVSGEDAILYAGSFLQGLEEYQAQLPVDDLLGQNKCTITVEFRTVPAQTEQSILRDISALLKEIAQQKPRFRYGEPRITMSRPTQKVAADHPFVQKAISCASDVLGSKPAVKAGPFWTDAALLGAVGIPSIVWGPAGEGLHAKEEWVEVGNLRQFEKVFTRLVQDFCY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W6QSP0</accession>
    <name>W6QSP0_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type DNA-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PROQFM164_S06g000079</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792020">
        <property type="protein sequence ID" value="CDM37119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QSP0"/>
    <dbReference type="STRING" id="1365484.W6QSP0"/>
    <dbReference type="OMA" id="YEMVSCT"/>
    <dbReference type="OrthoDB" id="5280547at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053175">
        <property type="entry name" value="DHMBA_Reg_Transcription_Factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791:SF5">
        <property type="entry name" value="TRANSCRIPTION FACTOR DBAG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDM37119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="530" mass="59809" checksum="BDCB652660290AD5" modified="2014-04-16" version="1">MPFYGRPSKCCGSCRERRIKASGCDRLEPLCSQCRRAGKPCGGYRDVPSSMFRDENDKAARRSAEAKAKTEARRRLEDSALEYDIPTPGSRPDCSPSDALVCRSRSQLIRTPRIAAPLSIPLEDQGLRFFINRFVTRIVTKEDGSLQIGTVKPSPEVGAITLDQSSRDAIVSVGLAALSNVNNDRELRILSREKHVTVIKAVREVVENPTQANPDRTLHLIVMLSLYEMVSCTPNQLNSWIVHMNGAAALLKQSIFRSSLTNLNHRAHLQFYFVSIVKYFSKRVVTPDLLNWSPDLIPSAPPDILPDVDLVDILIRYTKFDAHVHHQKPGSRAVVNSALLFEDELREWETHLPIHWSFAIKEPNTYEHTFRGQYHVYANMWVARVFNHYRWARLLVNETIVSQISKMARPTADDVIQRRQALDTISCMAGDICAGTASQEAIFEQGVNEDPSDIPLLNGTFMLLFPLGIAGSAAGIPDEVHDWVVEALERIGRTTGIRRALEMIPQLKKSAGKWKLDQKRWNRIHDRNES</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W6QVR7</accession>
    <name>W6QVR7_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Peroxidase</fullName>
            <ecNumber evidence="14">1.11.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">ccp1</name>
        <name evidence="16" type="ORF">PROQFM164_S03g000386</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Destroys radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>2 Fe(II)-[cytochrome c] + H2O2 + 2 H(+) = 2 Fe(III)-[cytochrome c] + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:16581"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.11.1.5"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="12">Forms a one-to-one complex with cytochrome c.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion intermembrane space</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peroxidase family. Cytochrome c peroxidase subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.-" evidence="14"/>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QVR7"/>
    <dbReference type="STRING" id="1365484.W6QVR7"/>
    <dbReference type="OMA" id="QRKWNGP"/>
    <dbReference type="OrthoDB" id="2859658at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004130">
        <property type="term" value="F:cytochrome-c peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000302">
        <property type="term" value="P:response to reactive oxygen species"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00691">
        <property type="entry name" value="ascorbate_peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.420.10:FF:000009">
        <property type="entry name" value="Ascorbate peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.520.10:FF:000005">
        <property type="entry name" value="Cytochrome c peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.420.10">
        <property type="entry name" value="Peroxidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044831">
        <property type="entry name" value="Ccp1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002016">
        <property type="entry name" value="Haem_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002207">
        <property type="entry name" value="Peroxidase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019794">
        <property type="entry name" value="Peroxidases_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019793">
        <property type="entry name" value="Peroxidases_heam-ligand_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31356:SF58">
        <property type="entry name" value="CYTOCHROME C PEROXIDASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31356">
        <property type="entry name" value="THYLAKOID LUMENAL 29 KDA PROTEIN, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00141">
        <property type="entry name" value="peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00459">
        <property type="entry name" value="ASPEROXIDASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00458">
        <property type="entry name" value="PEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00435">
        <property type="entry name" value="PEROXIDASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00436">
        <property type="entry name" value="PEROXIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50873">
        <property type="entry name" value="PEROXIDASE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0349">Heme</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5 14 16" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Plant heme peroxidase family profile" evidence="15">
        <location>
            <begin position="177"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU363051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CDM33662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="366" mass="40059" checksum="31EA7F66B29FE5DD" modified="2014-04-16" version="1">MASAARTASRAFLRSTPATSSFRPAARSTRFAIPANGVRASARRGYASEAGSEKSSSSFGLWALGLGALGAAGGAYLYLNDSSPKGPFVPTQADYQKVYDAIASRLADETDYDDGSYGPVLVRLSWHASGTYDKETGTGGSNGATMRFAPEADHGANAGLKVARDFLEPIKAQFPWISYSDLWTLGGICSIQELGGPKIPWRPGREDMEIAACTPDGRLPDGAKDQRHIRNIFGRMGFDDREMVALIGAHALGRCHTDRSGFDGPWDFSPTVFSNEFFRLLADEKWIPKKWNGPAQYTDKTTGTLMMLPTDMALVKDKAFKKHVERYAKDSDVFFKEFSDVYAKLLELGVPFKTEEHIVFKTSDSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W6QW44</accession>
    <name>W6QW44_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein SSH4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Protein ssh4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">ssh4</name>
        <name evidence="19" type="ORF">PROQFM164_S11g000042</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Components of the endosome-vacuole trafficking pathway that regulates nutrient transport. May be involved in processes which determine whether plasma membrane proteins are degraded or routed to the plasma membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SSH4 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792025">
        <property type="protein sequence ID" value="CDM38339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QW44"/>
    <dbReference type="STRING" id="1365484.W6QW44"/>
    <dbReference type="OMA" id="FFFKYTR"/>
    <dbReference type="OrthoDB" id="258495at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12910">
        <property type="entry name" value="SPRY_SSH4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.920:FF:000065">
        <property type="entry name" value="Ear1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035780">
        <property type="entry name" value="SPRY_Ssh4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050618">
        <property type="entry name" value="Ubq-SigPath_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12864">
        <property type="entry name" value="RAN BINDING PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0967">Endosome</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="8 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <keyword evidence="7" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="89"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="B30.2/SPRY" evidence="18">
        <location>
            <begin position="156"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="433"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="459"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="474"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="497"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00025244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CDM38339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="512" mass="55612" checksum="AAB5A63DED129A86" modified="2014-04-16" version="1">MQGLEASSPDALAGLPSTLSTVIGNPTTSPIGFVSSTLPSPTPIQSDLSLSRQQIQANLQNVLSSLSMEFRPEPMLASGNSSGSTGKGILIGILSAFGSAAVAFVVLAIFFFFKYTRRGRIMLDRIGRPGEYDDEQAFLREEEVALESMDDLARSEYLRAKAFVQGNPPESLQTDISLSQFLAIQEKGVSAWEFQPELEIANCFVEGRTEIEFFDSECSVQTNLPIPKQNDVYYWEAKIYDKPESTMIGIGVTTKPYPLFRMPGFHKTSVAYQSTGHRRLNQPFTPTPYGPPLLQGDVVGVGYRPRSGTVFFTRNGKKLEDVAHNYRSQNLFPTIGANGPCTIHVNFGQMGFVFIEGNVKKWGLAPMTGSLAPPPPYGSEQGSILLESGRESAAQISQRVYQNANYATSGSSLTHISSHEDAGEGSSRFALAETEGQGAAAPENQEPEAPPPEYSSPDGSRRGSDVSRECPPNFGSSDDPNCPSNDGQLLPSYQTVVERDLNEQNSEANDRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>W6QZQ3</accession>
    <name>W6QZQ3_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Chorismate synthase</fullName>
            <ecNumber evidence="4 8">4.2.3.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">aro-2</name>
        <name evidence="10" type="ORF">PROQFM164_S03g001774</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21020"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57701"/>
            <dbReference type="EC" id="4.2.3.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>FMNH2</name>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
        </cofactor>
        <text evidence="8">Reduced FMN (FMNH(2)).</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 7/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the chorismate synthase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.5" evidence="4 8"/>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM35047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QZQ3"/>
    <dbReference type="STRING" id="1365484.W6QZQ3"/>
    <dbReference type="OMA" id="MLSINAV"/>
    <dbReference type="OrthoDB" id="1721239at2759"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004107">
        <property type="term" value="F:chorismate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07304">
        <property type="entry name" value="Chorismate_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Chorismate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Chorismate synthase AroC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00300">
        <property type="entry name" value="Chorismate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Chorismate_synth"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR020541">
        <property type="entry name" value="Chorismate_synthase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00033">
        <property type="entry name" value="aroC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003793">
        <property type="entry name" value="PRK05382.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21085">
        <property type="entry name" value="CHORISMATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21085:SF0">
        <property type="entry name" value="CHORISMATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01264">
        <property type="entry name" value="Chorismate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001456">
        <property type="entry name" value="Chorismate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103263">
        <property type="entry name" value="Chorismate synthase, AroC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00787">
        <property type="entry name" value="CHORISMATE_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00788">
        <property type="entry name" value="CHORISMATE_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00789">
        <property type="entry name" value="CHORISMATE_SYNTHASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 8" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="389"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="390"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDM35047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="408" mass="43644" checksum="496140C3528F89E6" modified="2014-04-16" version="1">MSTWGQYFRVTTYGESHCRSVGCIVDGCPPGLELTEADIQPQMTRRRPGQSALTTPRDEKDRVEIQSGTEFGITLGTPIAMVVRNEDQRPKDYGGSTMDLYPRPSHADFTYLEKYGVKASSGGGRSSARETIGRVAAGAIAEKFLSLAHNIEIVAFVSSVGNEHLFPPTPEHPSPSTNPEFLKLIETIDRKTVDTFSPIRCPETEAAARMTKVIEKFRDNHDSIGGTVTCVIRNVPVGLGEPCFDKLEAKLGHAMLSIPATKGFEIGSGFGGCEVPGSIHNDPFVVNTSETGSPRLTTKTNNSGGIQGGISNGASIYFRVAFKPAATIGQAQTTTSYSGEEGVLEAKGRHDPCVTPRAVPIVEAMSSLVIMDALMAQYAREGAKNLLPQKAQTIRTSPTTAPNGAPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W6R1K8</accession>
    <name>W6R1K8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Fungal trichothecene efflux pump</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PROQFM164_S04g000593</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6R1K8"/>
    <dbReference type="OMA" id="FGRRWFI"/>
    <dbReference type="OrthoDB" id="4139357at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010573">
        <property type="entry name" value="MFS_Str1/Tri12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF195">
        <property type="entry name" value="PEP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06609">
        <property type="entry name" value="TRI12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="38"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="232"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="260"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="303"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="344"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="370"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="397"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="518"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="14"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM35712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="567" mass="60947" checksum="22A04822CA351A2B" modified="2014-04-16" version="1">MAVDSEKGSVQAGSPTETPSSPSISNEITEPVVTLKTWIVSSILSCGYGLSFWPIPVVAAIGSMVSADMGDPTGYIWFIPAWTISITCAFLIFGPNTDLLGRRWFLVLGNLVCFVGHIVVASAKNTNQIIAGLVISGFGGANCQMAAFALPELLPNKWRHIGVVIADFTVYIAVIVAPVTARYGYELGTWAWNFWGVAIFQGLSFLGLLFLYHPPKHPLGIPYKEAFKSLDYLGAFLFIGGAVPFLMGIVWAGVYDSNDVHVVAPLVVGAAVLICFALWESFGKLKYPLTPTYIFASSWGRDFTAPVIALGVVNMFYYSSSILWPQMITVFYTNGGADWKYSVILSLPQGFAIFFGAILLTCFGSKLRHWHWQLTGSVFVMVVFGSLLGIVTPTNKGTMIAFIFLSQAGFGWALYLSIAITQMGVEHKNLGVSGGISGCIRFAAGAVATSIYQTVYSNTLAKYTAIYVPSAAISAGLPESKVADLLAVVSQGAAAMKSYSPAVVTAAEAALSQAYCKAMFVVAMVSMAFGILGLAACLCCKDVDSKMTNKIEVYLENTDLSERNKYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W6R3J9</accession>
    <name>W6R3J9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S05g000210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6R3J9"/>
    <dbReference type="STRING" id="1365484.W6R3J9"/>
    <dbReference type="OMA" id="RTTFYWA"/>
    <dbReference type="OrthoDB" id="1523883at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM36377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="161" mass="17675" checksum="BFA0F07D082BAD97" modified="2014-04-16" version="1">MLLKECLKLAGHCQRNGDEELTTNTGFLQPSLQPTSDKVLPKWFSHVFNRAVWTVLALNLGTITSAAGTLFLNRYYPQKPLQTTAFYWVGLAGAVGHLVFVPFVAGPVKRIVDNVAVREDLGESGVGASADMRRWVGIHRIRMVVADLPAWIAFLGAVLTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W6R7I4</accession>
    <name>W6R7I4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Haloacid dehalogenase/epoxide hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S07g000135</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HAD-like hydrolase superfamily. S-2-haloalkanoic acid dehalogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792021">
        <property type="protein sequence ID" value="CDM37787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6R7I4"/>
    <dbReference type="STRING" id="1365484.W6R7I4"/>
    <dbReference type="OMA" id="VCWVNRR"/>
    <dbReference type="OrthoDB" id="3256520at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019120">
        <property type="term" value="F:hydrolase activity, acting on acid halide bonds, in C-halide compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02588">
        <property type="entry name" value="HAD_L2-DEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006328">
        <property type="entry name" value="2-HAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051540">
        <property type="entry name" value="S-2-haloacid_dehalogenase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01493">
        <property type="entry name" value="HAD-SF-IA-v2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01428">
        <property type="entry name" value="HAD_type_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43316:SF3">
        <property type="entry name" value="HALOACID DEHALOGENASE, TYPE II (AFU_ORTHOLOGUE AFUA_2G07750)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43316">
        <property type="entry name" value="HYDROLASE, HALOACID DELAHOGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00413">
        <property type="entry name" value="HADHALOGNASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM37787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="236" mass="26703" checksum="8DCD6C262408548D" modified="2014-04-16" version="1">MCAKILLAFDLYGTLLSTESIQSHLQIHFEPEIARAISEKWRRFQLEYTWRLNSMSRYEDFTEVTRNSLLHALAENGQSLDDASISQLMTAYDNLSAFPDVAPALDKLSQESLFKPVIFSNGSNVMVSNSVNRCLSQHASIFHGLLTADDIQRYKPSRLFYQRLAEQFGKGLANEDIWIISANPFDIVGSRNMGMRAVWVDRAGSGWKDAVIPDLKPTLVVHSLQDVTDKIQAYIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W6R7L8</accession>
    <name>W6R7L8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Dihydroxyacetone kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PROQFM164_S07g000175</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes both the phosphorylation of dihydroxyacetone and of glyceraldehyde.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>D-glyceraldehyde + ATP = D-glyceraldehyde 3-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13941"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.28"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>dihydroxyacetone + ATP = dihydroxyacetone phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15773"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16016"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.29"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Polyol metabolism; glycerol fermentation; glycerone phosphate from glycerol (oxidative route): step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the dihydroxyacetone kinase (DAK) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792021">
        <property type="protein sequence ID" value="CDM37827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6R7L8"/>
    <dbReference type="STRING" id="1365484.W6R7L8"/>
    <dbReference type="OMA" id="TLGNMSG"/>
    <dbReference type="OrthoDB" id="1724672at2759"/>
    <dbReference type="UniPathway" id="UPA00617">
        <property type="reaction ID" value="UER00669"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004371">
        <property type="term" value="F:glycerone kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050354">
        <property type="term" value="F:triokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019588">
        <property type="term" value="P:anaerobic glycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1180.20:FF:000001">
        <property type="entry name" value="Dihydroxyacetone kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10440:FF:000001">
        <property type="entry name" value="Dihydroxyacetone kinase, DhaK subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10440">
        <property type="entry name" value="Dihydroxyacetone kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1180.20">
        <property type="entry name" value="Dihydroxyacetone kinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012734">
        <property type="entry name" value="DhaK_ATP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004006">
        <property type="entry name" value="DhaK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004007">
        <property type="entry name" value="DhaL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036117">
        <property type="entry name" value="DhaL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050861">
        <property type="entry name" value="Dihydroxyacetone_Kinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02361">
        <property type="entry name" value="dak_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28629">
        <property type="entry name" value="TRIOKINASE/FMN CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28629:SF1">
        <property type="entry name" value="YALI0F01606P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02733">
        <property type="entry name" value="Dak1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02734">
        <property type="entry name" value="Dak2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01120">
        <property type="entry name" value="Dak2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82549">
        <property type="entry name" value="DAK1/DegV-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101473">
        <property type="entry name" value="DhaL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51481">
        <property type="entry name" value="DHAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51480">
        <property type="entry name" value="DHAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0319">Glycerol metabolism</keyword>
    <keyword evidence="6 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DhaK" evidence="14">
        <location>
            <begin position="11"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="DhaL" evidence="13">
        <location>
            <begin position="389"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-hemiaminal-histidine intermediate" evidence="11">
        <location>
            <position position="223"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="56"/>
            <end position="59"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR612734-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR612734-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CDM37827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="592" mass="63113" checksum="96898706FD2DE408" modified="2014-04-16" version="1">MSDKHYFPSTSANSLVPRALRALVSANDHLSLNYTERVVSNAFHDDSKVSIISGGGSGHEPAWSGYVGDGLLSAVACGDIFASPSAKQILAAIRTAPSKKGTILLITNYTGDRLHFGLAAERAKAEGLVENIAILHATDDVSIGRSKNSHMGRRGLPGHIFTMKIIGAAASEGYSFKQCLALGQAINGQTVTIASALDHCHVPGRHQQSSVPDNVVVVGAGIHNEPGQLHLSPAPPVEQLIEQCLKFLCDDSDTERAFVKFEPRDEIGLLVNNYGGLSVLELSALTDEIQCQLSSRWNIRPCKTLFGSFETSLNAPGFSISLCNLTAAARQSNQSVATLIRHFDCPTTAVSWPNTSRPSPSQQKTTFDDLDAEVNSQITASPRIKFDPLLLEKALRTSCERAIAAEPRLTQWDMVMGDGDCGEAVQGLAESVLQSVDKGCTASGDLLEVIRSVLQNVDDMGGTLGAIFGVLLSALYTALRKNSLDGICPNTPNFYSTALASATTTLKSHTGAREGDRTVMDVLLPFSEEFSKTNDFLSAVDVAAKKAEETRHLKAKFGRATYVGDASSQQLPDPGAWALYEIVAGLADGLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W6R830</accession>
    <name>W6R830_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6570 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S08g000068</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792022">
        <property type="protein sequence ID" value="CDM38017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6R830"/>
    <dbReference type="OMA" id="EHYVHRT"/>
    <dbReference type="OrthoDB" id="5424209at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046700">
        <property type="entry name" value="DUF6570"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20209">
        <property type="entry name" value="DUF6570"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6570" evidence="1">
        <location>
            <begin position="11"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM38017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="624" mass="69394" checksum="95630212D4BAABED" modified="2014-04-16" version="1">MIKEPADRVYLFGSRNNMDPGDVPTFLPELTQVEEMLVSRVHTIIEVRQIARKMAEAFPSPRKRRRLLQESEVNEGDMEIEHYVHRTDPFRSISFPNPDPTALNVTTMTAEEDPTQHLHRGIFNTLDQYGLPAKSLFHMLNATIPGASFPLLRVVVASDHSALVEVINGDHFYIPTLFPIHSTAELSIAFHHLKDEIVRLLDETLGTKWQLVCPFNIGRDSRSARPALGVGVLPSTNANWYQLQAHLTHRLTSHIRPIFTDIEFLPGKLSLLGEGDPVSFKDRVKGPKDIQMGCSIGVRGGNNASTLGGFVAVTYDGETHRGLLTNYLVMRPSPPYANLDTINREGVSPLSPIPFQGAISIESLARIDRDYTLTDLDDQLQALETQKARVVDFIRQRQLTSDAPRASSQQQLEAVETWEKTLIATRPVIQAMPHVLGDVHSASGLLVHGRRVIDWAFVELTPEAEERFFRPNRMPEVPRNQMPRSGPSGPPPALVAAGTRLDEFSSLQEDTYYIKQGRTTDVTGVVCNGVLSVCKWATRYDINGNTVDSKDLRTEEFMIIGIQDRFIEFGDSGSFVVDSTGAVAGLVFAEFKHNLQAVGLALTVPDLMDTMEGRLKGPVSLRLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W6R8X9</accession>
    <name>W6R8X9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ubiquitin supergroup</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PROQFM164_S10g000091</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792024">
        <property type="protein sequence ID" value="CDM38277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6R8X9"/>
    <dbReference type="STRING" id="1365484.W6R8X9"/>
    <dbReference type="OMA" id="NASWSRW"/>
    <dbReference type="OrthoDB" id="21589at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039751">
        <property type="entry name" value="HERPUD1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12943:SF27">
        <property type="entry name" value="HOMOCYSTEINE-INDUCED ENDOPLASMIC RETICULUM PROTEIN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12943">
        <property type="entry name" value="HOMOCYSTEINE-RESPONSIVE ENDOPLASMIC RETICULUM-RESIDENT UNIQUITIN-LIKE DOMAIN HERPUD PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="6">
        <location>
            <begin position="21"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="115"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="321"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="512"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="119"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="322"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="339"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="512"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="558"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM38277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="569" mass="62289" checksum="0D54D02122E42390" modified="2014-04-16" version="1">MATGLPSQPIVEGETPRTITLHILCQSLPPPSRFTLENVPLSSTVGQLKSRIEQSFPNNPQVSHQRLIYRGKPLTVDDATLGVVVSSIEEGTDSMHLVLPPEPAHTEVPIVSEMPQDSPFGNSAQDSGSSSTWLDHSNPDTSVPAASVSSYSSIPRTIGAASASPHMIINQYVNTSLPNRHSATTNAPEADSTESSQRILTLRRYIEEIEGQLDRRLMPSMESIIHIRNQILGIQDARPATQLPLPGVAELLARILDVQQRARIMEYMQQQHSQASILAQAPIATQTNVLNTLAPNSTQLFMLTSPTGENLLVRPNCVARPRTQQAGSPNTAPANQTGAPQVPNAPQAPQAPNQNAAVVQNAIRQAMLNQQRRGNNVEHAGLARHIRRIWLFTRLWLFCYLTSAPGTWRRYIFVSIALLVTFFSETSIPRQFATTIIGPIQRHLEGLTHAGGPADRATQNGANNAAAEFSIWDQICRAERALVFLFASLVPGLGERHVQARTAADQAFLAEQERQARERQEQEQEQEQVREQEGQEQERAQPGVPEGAESAGTEHEGVSNTHAQSEQGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W6PQQ3</accession>
    <name>W6PQQ3_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Probable transposable element</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S01g000034</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PQQ3"/>
    <dbReference type="STRING" id="1365484.W6PQQ3"/>
    <dbReference type="OMA" id="QANITRR"/>
    <dbReference type="OrthoDB" id="4252713at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF483">
        <property type="entry name" value="PEPTIDE SYNTHASE GLIP-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="3">
        <location>
            <begin position="199"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="430"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="441"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM26225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="1009" mass="113126" checksum="6D55B9D92FC69275" modified="2014-04-16" version="1">MKLNDLTVTLKDVRHILERIPTLCQRRFCMIRDLFHKRSTPPFHYVLEDPSNQRFFAVRNSSDVYTFTADEPFEVSSQAFVIIATPANSRLTSDEPIPIAGEQQLVAYFSSNAKSNIKAKPSSGDEHVSKASIDIKSAFPTTLWEWHVTLAHLNYRDVLYLANRPGSGVKITGDKAQPPCQVCLQANITRRYSRRQASRATRPLMRIHVDIVGGGDVFSDDDDASQAANLQSRHGYKYFLLITDDATRFRWIYSLISRDRREIAARLRYWRQHINNLGFKTPAFLRSDNEFGSGELQSMMTEWGCQWEPSNPYSAWQNGTAERANRVVLEKARAMWIASGLPMTFWFHALVAASIQPQDTRIPIEAISKIPADLSYLLPFGSSIFYHLHGTSEPTGKLEPRGKIGRVVGYNGASIYTVWDPETGRLFNTGDIRPTGAARQTPFQGGEQVTKQTPDSTSSEELTDPITDDNWVRPAKEVKVFAAMTKTSQSAADVPRSFKEAMESVDRVLWDAACRKEVDDLHKRNTWELNRTGDVPIGLRPIPGKWGFAKKQAVDGTTRYKARWVIRGNISNGHQSLWGETAAPFVMASTKLVLFAAAAHYGWHIAQADAITAFLNGKLPNSVYMRQPYGFEQGERGTLVCKLKQALYGLIPAARIWYDTLREKLEAIGFRISPYDAGLFLHKTKPNLYVTAHVDDFGIIGANRTEIQWILSEMGKQFPIKDLGQMEHYLGLRVEQTEAGIKLSQPDFIDKLLDDAGMPDCYPVATPIEPGLVIDDLHDLSIDKRQYQSVTGSLQWLASHTRPEIARVPTLLAHFNTVPTQKTLSTQRRVLRYLKGSKQLGIVFRPGSGMLPPPVLYTDADWGGPLTPGRRSCSGYVMLLAGGPVSWRSHLQASVALSSNKAEYMAVSDAAREVEWLTRLVADMGLYAADAEPITFYMDNKGAHDLVRTSFVSRRSKHVDIRYHYVRDIAARGIINPTPIGTRDMAADGFTKPLAEESFKRFGGQIGVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W6PR37</accession>
    <name>W6PR37_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Sulphur transport domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PROQFM164_S01g000467</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PR37"/>
    <dbReference type="OMA" id="CYTPVYP"/>
    <dbReference type="OrthoDB" id="10254418at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046513">
        <property type="entry name" value="DUF6691"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007272">
        <property type="entry name" value="Sulf_transp_TsuA/YedE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30574">
        <property type="entry name" value="INNER MEMBRANE PROTEIN YEDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30574:SF1">
        <property type="entry name" value="SULPHUR TRANSPORT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20398">
        <property type="entry name" value="DUF6691"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04143">
        <property type="entry name" value="Sulf_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="47"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="160"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="230"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM26658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="330" mass="34808" checksum="92513A1881655C97" modified="2014-04-16" version="1">MFTPIHTTLGALLLFHGSSGLLIHNGAVFGISSLLSGCAFNPSRDNVPIIAGLVSSIVPVYLLAPSLIPNYPASPHSWASAAATLGVGFLLGWGTKNGQGCTSGHMLCGLSRLSPRSLIATAIFFTTALLTANIVKGRSNIPSCGTTPCYAPVYPSESELGFMAGAVLLAGITNFIVVPRKARRSEESRVIYSYVTGLEFGLGLFISGMADPAKVLRFFAFLTDPSRFDPSLALVILFGIGPSLIIFLIQKPGQAVEKGKPVAKPTLAEKWRLPTATVSDIDWRFVIGAATFGLAWGLEGVCPGPAILRTILQPTWGLITMGGYMLGNLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W6PRG7</accession>
    <name>W6PRG7_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">YjgF/Yer057p/UK114 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g000577</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RutC family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PRG7"/>
    <dbReference type="STRING" id="1365484.W6PRG7"/>
    <dbReference type="OMA" id="ECTAYLN"/>
    <dbReference type="OrthoDB" id="309640at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019239">
        <property type="term" value="F:deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00448">
        <property type="entry name" value="YjgF_YER057c_UK114_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.40:FF:000001">
        <property type="entry name" value="L-PSP family endoribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="entry name" value="RutC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006056">
        <property type="entry name" value="RidA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00004">
        <property type="entry name" value="Rid family detoxifying hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
        <property type="entry name" value="2-IMINOBUTANOATE/2-IMINOPROPANOATE DEAMINASE RIDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803:SF42">
        <property type="entry name" value="MMF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="YjgF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM26768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="140" mass="14755" checksum="EC8F4B621909AFD1" modified="2014-04-16" version="1">MSKPTRTPVSTKGAPTPPPILSQGIVVGNMVYCSGQLGVDPTTGQMVEGSIQNRTRQILRNLNAVLEAAGSSLQDAVKVNIFLTDMADFSAVNEVYATFFSDPKPVRTCVAVKSLPQGSDVEIECSGLVTKPGSGRSSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W6PT65</accession>
    <name>W6PT65_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Aromatic-ring hydroxylase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PROQFM164_S01g001189</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PT65"/>
    <dbReference type="SMR" id="W6PT65"/>
    <dbReference type="STRING" id="1365484.W6PT65"/>
    <dbReference type="OMA" id="SIGLWPN"/>
    <dbReference type="OrthoDB" id="10029326at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050562">
        <property type="entry name" value="FAD_mOase_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47356:SF2">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47356">
        <property type="entry name" value="FAD-DEPENDENT MONOOXYGENASE ASQG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="449"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="10">
        <location>
            <begin position="10"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="10">
        <location>
            <begin position="295"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDM27378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="476" mass="53750" checksum="013D19B267928A5A" modified="2014-04-16" version="1">MEEGMEAPKFKVIIVGGSIAGLTLAHSLSQANIDHVVLEKRASIAPQEGAFIGVWPNGAQILDQLGLYHSLEKLTAPLSRMHLSFPDGYSFSSLLPKTIHEIFKYPIVSLDRQKVLEILFQNYPNKEKIITNQRVSEVRLLGDSASVVTEDGSVFQGDLIVGADGVHSRIRSEMWRLADELHPGMITPQERQTLTVEYACVFGISRAIPGLRSGEHINHYGDKFCVITFHGKDGRVFWFIIQKLDRVYTYPNAPRYSPNDAAELCDKIQDVIIWRDITVGDLWKTKLVSSMTALEEGLFETWSLNRIVILGDSVHKMTPNIGQGANTAIEDVAVLASLINRVVHADALHKPSESCIETMLQKYKTLRYERAKSTYERSRFGARFHTRDNWLKALVGRYVFQYVGGLIENRTSKTLAGGNVIDFLPRPHRLETGCVTRLPKGQGRPQQQWTLLWVSSLVLFLFLPWLRSYLPSATFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W6PT90</accession>
    <name>W6PT90_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="13">CDR ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PROQFM164_S01g001224</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1365484.W6PT90"/>
    <dbReference type="OMA" id="NTQQGFQ"/>
    <dbReference type="OrthoDB" id="245989at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03232">
        <property type="entry name" value="ABCG_PDR_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000054">
        <property type="entry name" value="ABC multidrug transporter atrF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029481">
        <property type="entry name" value="ABC_trans_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034003">
        <property type="entry name" value="ABCG_PDR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010929">
        <property type="entry name" value="PDR_CDR_ABC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19241">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14510">
        <property type="entry name" value="ABC_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06422">
        <property type="entry name" value="PDR_CDR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
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    </dbReference>
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        <property type="entry name" value="ABC_TRANSPORTER_1"/>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="499"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="532"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="574"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="606"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="639"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="744"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1160"/>
            <end position="1180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1192"/>
            <end position="1211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1245"/>
            <end position="1263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1275"/>
            <end position="1295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1301"/>
            <end position="1322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1334"/>
            <end position="1355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1427"/>
            <end position="1447"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="133"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="820"/>
            <end position="1062"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1104"/>
            <end position="1126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDM27413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="1459" mass="164914" checksum="0416FA742FE5B5C8" modified="2014-04-16" version="1">MPDAPRSSKLYTNIHIGPFLAMEDYGDPEFAPITERTGTILEEREQQTLTRIASSKIGQQLSRSASTKEGIPPYLDPTNPRFDHRRWAQMVLEQVNDSGIDILNQGVVFSNLSIHGSGSALQYQETLTSSLRVPFRAATRALTGHTSPPRQILRNFDGLLQGGELLLVLGRPGSGCTTFLKTICGHLGGLTVGPESSIHYKGIAFEDMIKHHRGDVAYNKEVDLHFPHLTVGQTLTFAAHARAPQQRLKGVTRNEYVETITQVVLSVFGLSHVYNTKVGNNFVRGVSGGERKRVSIAEMFLSRCRIGAWDNSTRGLDAASALKFVRSLRLSADMGQSCHAIAAYQASQSMYDLFDKVVLLYEGYQIYYGPRERAVSYFQDMGWQRLERQVSGDFLTAITNPAERTARPGMEGKVPRTAKEFSEYWKNSPEYQLLHKEISEFEREHHPNVDEKKRLMESHKEQQARHTRARSPFLLSIPMQVRLCIHRAYQRMLQDLPTAMAPVIVQIILSLIIGSIFYNTPDTPNFFFQKGAVMYFAVLMNAILTINEILQLYAQRPVVEKQAGYAFVHPFTEALASLIIDLPIKIIRISIFTVVLYFMANLRREAGAFFIHYLFLLTAVLAMSGLFRSVGALTKSVGQAMAIAGVLVLCIVVYTGFTLPQPYMHPWLSWIRWISPIYYTFEALVANEFHGRTFDCSAFIPSYGTGTSFICSTVGAVAGQRTVSGDAFIEANYEYKHSHLWRNYGILIGFFIALNTLYLVATEYLTDDKSKAEALVFRPGHAPKYLQEGHSIELGIQEVNKLELQMTNDTIRLPEQKDILSWNSLNYDIPVKEGTRRLLDNVNGWVKPGSLTALMGVSGAGKTTLLDVLAQRVSIGVVSGDIFVNGKTLAANFPRRTGYVQQQDLHLDTTTVREALRFSAMLRQPQKVTKHEKYEYVEQVIKVLGMEDFAEAVVGSLGEGLNVEQRKLLSIGVELAAKPTLLIFLDEPTSGLDSQSSWTICQFLRRLADHGQAVLATIHQPSAQLFQTFDRLLFLAKGGKTVYFGDIGNQSSTLLNYFENNGARPCEELENPAEYILEMVAGDSCPIDWVAAWNKSPEYEEVQAEVERLHNDPKQSSYRPSLDGPDEFDDDNSEFAMPLRSQLYYVLERVFQQYYRQPEYVYSKFILGIVSGLFIGFSFWKSDNTQQGFQNVLFSIFLLCTIFNTLVNQIMPKFVVQRSLYEVRERPSRIYSWKVFILSQMFVEIPFQVCLGVCSWACFYWCVFGADQDSERRALIMLFIVQFYIYAASMAQLVVCAIPEPALAAMVATLMFGLSFIFNGVMQPPDDLPRFWIFMYRVSPFTYYIGGISATALHGRPVECNAAEMSVFDPPSGQTCFQYMEKYLETAAGTLANYNATSGCEYCSLSSADQYLAARKIEWVHRWRNYGIFWCYFFFNIFAAITLYYLFRVRTSKAKTKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W6PTL6</accession>
    <name>W6PTL6_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Short-chain dehydrogenase/reductase SDR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S01g001029</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PTL6"/>
    <dbReference type="STRING" id="1365484.W6PTL6"/>
    <dbReference type="OMA" id="WRHAVPH"/>
    <dbReference type="OrthoDB" id="47007at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005559">
        <property type="entry name" value="PRK07231.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43639">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT-CHAIN DEHYDROGENASE/REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_5G02870)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43639:SF1">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM27220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="253" mass="27434" checksum="935483D8A630B3F2" modified="2014-04-16" version="1">MPLRAKMNTPRVVIVTGGADGFGAAIVDRFSREGCKVIILDLDQVKGESKQRADQNIEFLLGDVTRPETWQNALALAQTTHGRVDVVVNNAGITHDPSPIHTKSLLEYEKTFNVNVKPVFISAQVFAPVMMQQGHGIFINITSTGCTRPRPGFAIYNASKAAVEVATKTMALEYAPAVRFNCISPAVGNTSMLQSSIRNGADSRQRLRQVEDSLPMKRLCQPVDIANAAWYLGSEQSSFVTGTTLEVDGGRGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W6PUZ9</accession>
    <name>W6PUZ9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g001526</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PUZ9"/>
    <dbReference type="STRING" id="1365484.W6PUZ9"/>
    <dbReference type="OMA" id="CSFTRLS"/>
    <dbReference type="OrthoDB" id="4991875at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004881080" evidence="1">
        <location>
            <begin position="18"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM27715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="210" mass="21529" checksum="5109D50CBCDE80D2" modified="2014-04-16" version="1">MRSSWFLVSLLAALTTADEPSTTTVSYFGIDNPYGANIGAYSSIAARVAGIDKYATTYEIACMAGASKCALNRPATLIQGDATYSVSLEVTVVTKGATAQATAVESCSFTRLSESARCTWKYEYTASEGDHTISDSTSSTQSIPSYSVIYHPLTVTDGIYAFKANATGSTTPVKITPTASTAGAAAAAKPLITAAPLGAVAAAAAFAAML</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W6PVT5</accession>
    <name>W6PVT5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g002139</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PVT5"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM28328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="70" mass="8244" checksum="4B36D5CB783A4941" modified="2014-04-16" version="1">MLMRQVWEVRRRECKCKVGGRLWCDRKSVPPVRAEGKKRPRSKIQSNDPGAKVGKWRLDGARVTRRVNRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>W6PVV0</accession>
    <name>W6PVV0_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="10">DNA repair protein, Rad18</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PROQFM164_S01g002154</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PVV0"/>
    <dbReference type="STRING" id="1365484.W6PVV0"/>
    <dbReference type="OMA" id="DDVHQNL"/>
    <dbReference type="OrthoDB" id="166134at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15761">
        <property type="entry name" value="FYVE1_Vac1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15737">
        <property type="entry name" value="FYVE2_Vac1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052727">
        <property type="entry name" value="Rab4/Rab5_effector"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006642">
        <property type="entry name" value="Rad18_UBZ4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021565">
        <property type="entry name" value="Rbsn_Rab-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036531">
        <property type="entry name" value="Rbsn_Rab-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13510">
        <property type="entry name" value="FYVE-FINGER-CONTAINING RAB5 EFFECTOR PROTEIN RABENOSYN-5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13510:SF44">
        <property type="entry name" value="RABENOSYN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11464">
        <property type="entry name" value="Rbsn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00734">
        <property type="entry name" value="ZnF_Rad18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140125">
        <property type="entry name" value="Rabenosyn-5 Rab-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004879783" evidence="8">
        <location>
            <begin position="21"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="domain" description="FYVE-type" evidence="9">
        <location>
            <begin position="236"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="FYVE-type" evidence="9">
        <location>
            <begin position="375"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="46"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="575"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="75"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="578"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDM28343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="709" mass="78780" checksum="8CEB065C926DFBE6" modified="2014-04-16" version="1">MQGWLHIIGISLRSTPTLFCTANGCCAETASIPASHAPMIMSRRTLGGGRVLGNPSALTSAPSPQPKPRVLSPTASSVSLNSQSASQLSTETQDLTSRISIENGDTSISAAPAAPGAQLSCPICSEQMMTLLQLNRHLDDIHQNLEESHQDEVKDWFKVQMEKARKFQPLAVLNQKLKGLDVFESNENQGAPLPIRPLAAHAGIPEPPKLLDPEDLITKDHWQTSCIYDECLEPSCGKRLNATNGCVNCRSCGKLFCEEHTMYQMKLSRAAHHEPVRGIWARVCETCYKSREGYNDHNGIVRDRTDAFKSIRKQTVDKEFLEISRLEKRLTRLTQLLASLPPDQIHPSATKLWSLAWQNDRRKEIEQTIVSWQDDASVSRCPFCQQEFSGYTFRRHHCRTCGRIVCGDPSTGCSSEVGLSISPGPTATSEKTNGDNLVNIDVRLCKDCKSTLFDRRDFKADMTRKPSEIRAYENLTQFERGIRLHLPRFQKLLTALQDPRRPPSSAQIADASKVRKRLIDSFAQYNVAARRIRDMPTNSPTQQKLQQAIYQQASNFLHLHMLPLKSLPKILKHTTPASERIPSRTSSPSTPVNGSTTGLRPPESALSSIKYNSIAASGSNSSLSSDTSSAVSALEAEEKSLRDRLIVLEEQKFFVSEMIADANRRRKFDEVSSLAMNVEDLSREIDRVNGMLAGLDFEGVYTGHPQASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>W6PW69</accession>
    <name>W6PW69_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Casein kinase II, regulatory subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PROQFM164_S01g001842</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PW69"/>
    <dbReference type="STRING" id="1365484.W6PW69"/>
    <dbReference type="OMA" id="DEIGIMY"/>
    <dbReference type="OrthoDB" id="3971593at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000435">
        <property type="term" value="P:positive regulation of transcription from RNA polymerase II promoter by galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF5">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="565"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="51"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="16"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM28031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="745" mass="83173" checksum="A5EA380014139FC9" modified="2014-04-16" version="1">MASESPQIEMSPPQSDPRDHSVGASDSNKRKAEQGNGTQARTKRNRYISIACNECKRRKIKCNGQMPCQRCGHLNLECRYAPNCCNNNFKDSDEFRSITDQITTLQDQVNSLFSNLNELRTQRPAFESPDFEHLSRNGSQSVYTPIQAGLEKSRARPPRFHGPTSSAFNFDVAKSSLQNMGITPAEDGIPDGLTTAHVSPTGSPPPNLGQLLPTTHPTKDPIWTIPREDAMRLCKVYEEEIGIMYPVVDIAKVTSQANLLYTFIEAATRTGFAQRGFPGSDGLHDESSIILKLILATTLVVEGGGQSELGHRIYLDVKPFIESKLWEPHTIKTIQLFAIVATYHYHTDDDAMAYRLIGLAARMCLEMGLHRRNALVKSFPDEVQWDEITRLFWSVYSLDRRWSLGTGLPFVIQDEDIDPNLPEPDASLPYLRCMVLYNRISSKIWYSGLGSEGTTDIRRDEIGYLDYQILQWYKQVPEELKFYPVDSPKNGENVSRGMKRLRVLLYLRMNQLRILIYRPVLHSSASIAEDRGHAQTVVEVAKDSIRVLTRLNQLSDIYRTQQITFNYFLVAALAVLFLAVSHAPVDFNRQVRDEFYMALDLVNGFSTKSYVSKRLWKTIKGLRKIGEKLGVLARPFGTDSNDPHSSAAVAMAGLAGHPIQDLSMYGPLNGGNELGSSPLNGLQMSQELTNLFEAVGAFGNFISNTSSDGINGFVGPDGEIQNTGEGLSGVLGDEGEFARVIRDLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W6PWR5</accession>
    <name>W6PWR5_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Spindle pole body component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PROQFM164_S01g002509</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
            <location evidence="5">Cytoskeleton</location>
            <location evidence="5">Microtubule organizing center</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the TUBGCP family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PWR5"/>
    <dbReference type="STRING" id="1365484.W6PWR5"/>
    <dbReference type="OMA" id="DYCFHVG"/>
    <dbReference type="OrthoDB" id="775571at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051011">
        <property type="term" value="F:microtubule minus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1900:FF:000013">
        <property type="entry name" value="Spindle pole body component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1900">
        <property type="entry name" value="Gamma-tubulin complex, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007259">
        <property type="entry name" value="GCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040457">
        <property type="entry name" value="GCP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042241">
        <property type="entry name" value="GCP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041470">
        <property type="entry name" value="GCP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302:SF70">
        <property type="entry name" value="GAMMA-TUBULIN COMPLEX COMPONENT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04130">
        <property type="entry name" value="GCP_C_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17681">
        <property type="entry name" value="GCP_N_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3 5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma tubulin complex component protein N-terminal" evidence="8">
        <location>
            <begin position="174"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="domain" description="Gamma tubulin complex component C-terminal" evidence="7">
        <location>
            <begin position="590"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="75"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM28698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="953" mass="107882" checksum="8925BBD2C5383BCD" modified="2014-04-16" version="1">MDYDHELDPFSSESLWRLSKFSIEALQPLGSLPWNTTLSGDTTSCFEIYPQPEDKIDPVWKLDLFPTGLEKPESVTDSSINPSIDSESDTTCDSLRDISGDNNDIWSLDLLQEEPGQIPPQKSWERYQHKSFQEPVSAYFSESGAQGFDAALVQRNMVKKDGAPTRIVRTDVFIRSLLRLGLGWSSAFFRYDQRTNQFERCLKDNIRVSGISLMALENVIENVVQCGTNMQRLRLFAQDPPANYRELSTFFTLTSTVEIIIFNLEQQISDHSKNIASLLQIKALFHRCGDVVGVLAAIVGAAQRAVSDAQVISIVVERAAFFAQKFGWIENLVHEIVIRVTQPWFGFIETWIGLRSEDAALKEYMTNDKSFVRLETYDRGKFKTGPARIDYIYQAEHMPSFIPADQARSIFECGRSLQLLKRSHPRHPIARRDVLSRIGGLHLHCATTWAGIEQIQTKAQEYESRLRAEIKKYHQGDAGLQDSSSNVVTQTVDQTANTEVTTTAFQLFDIDDEKNDSGPVTDYKALSKDGLKRLLDKARGFEAEDTNERSYLGPELTYGLHLSLAPILSSQALLIDYSCLHLLFKEHRIRHHLNMQWRFQLLGEGSFVARLSNSLFDPEMESGERRAGKVRSGVDTGLRLGSRDTWPPASSELRLVLIGLLGDCYFGGTNTEDDEKTHAQKDKELPGGLSFGIRELTDEEIEGCKNPNAIEALDFLRLQYTPPEVLESLITARSLNKYDCLFKHLLRLIRMASAVKRLIRDSTARGSLSGDTHNVYQKFRMDAQHFVLAVSDYCFHIGIGSIWQRFQDTLTKIEHCLNRGDIDGTIEAAHSVPRLRDYHEDILDQMLFALFLSKRHAQAAKLLESIFGTILSFGLLSRADGIGMRNESEGAVLHLYQSFRKQTSAFVNYLRSMESGKATSKSMAKSGEFFSSRTDPTSVFEHLRVRLDVKNYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>W6PX74</accession>
    <name>W6PX74_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S01g002624</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PX74"/>
    <dbReference type="OrthoDB" id="10464451at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM28813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="79" mass="9025" checksum="5726B1894AAE3325" modified="2014-04-16" version="1">MKRPGIFYTVFAQTPNSIPHPTEYYSVLGLDTLNKSESEAMMEGRYGQPFARTVRFSRNPLKPVEGQWRASGGWRFPAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W6PXF4</accession>
    <name>W6PXF4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Dihydroxyacetone kinase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">dak1</name>
        <name evidence="15" type="ORF">PROQFM164_S01g002714</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes both the phosphorylation of dihydroxyacetone and of glyceraldehyde.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>D-glyceraldehyde + ATP = D-glyceraldehyde 3-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13941"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.28"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>dihydroxyacetone + ATP = dihydroxyacetone phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15773"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16016"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.29"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Polyol metabolism; glycerol fermentation; glycerone phosphate from glycerol (oxidative route): step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the dihydroxyacetone kinase (DAK) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PXF4"/>
    <dbReference type="STRING" id="1365484.W6PXF4"/>
    <dbReference type="OMA" id="ALNMNGF"/>
    <dbReference type="OrthoDB" id="1724672at2759"/>
    <dbReference type="UniPathway" id="UPA00617">
        <property type="reaction ID" value="UER00669"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004371">
        <property type="term" value="F:glycerone kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050354">
        <property type="term" value="F:triokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019588">
        <property type="term" value="P:anaerobic glycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10440:FF:000002">
        <property type="entry name" value="Dihydroxyacetone kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.340:FF:000001">
        <property type="entry name" value="Dihydroxyacetone kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1180.20:FF:000001">
        <property type="entry name" value="Dihydroxyacetone kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10440">
        <property type="entry name" value="Dihydroxyacetone kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1180.20">
        <property type="entry name" value="Dihydroxyacetone kinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012734">
        <property type="entry name" value="DhaK_ATP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004006">
        <property type="entry name" value="DhaK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004007">
        <property type="entry name" value="DhaL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036117">
        <property type="entry name" value="DhaL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050861">
        <property type="entry name" value="Dihydroxyacetone_Kinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02361">
        <property type="entry name" value="dak_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28629:SF14">
        <property type="entry name" value="DIHYDROXYACETONE KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28629">
        <property type="entry name" value="TRIOKINASE/FMN CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02733">
        <property type="entry name" value="Dak1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02734">
        <property type="entry name" value="Dak2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01120">
        <property type="entry name" value="Dak2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82549">
        <property type="entry name" value="DAK1/DegV-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101473">
        <property type="entry name" value="DhaL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51481">
        <property type="entry name" value="DHAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51480">
        <property type="entry name" value="DHAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0319">Glycerol metabolism</keyword>
    <keyword evidence="6 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DhaK" evidence="14">
        <location>
            <begin position="9"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="DhaL" evidence="13">
        <location>
            <begin position="386"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-hemiaminal-histidine intermediate" evidence="11">
        <location>
            <position position="224"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="57"/>
            <end position="60"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR612734-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR612734-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CDM28903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="591" mass="62714" checksum="8551090BF6F9B3EF" modified="2014-04-16" version="1">MQTKHFFADPDHLVLTALNSLTLTNPSLALDQQHKIIFRRPDAPRRANKVSIVTGGGSGHEPAFAGFVGHGLCDASVAGTIFASPSAEQIRRAVIDRVPTDNGVLIIPMNYTGDVLNFGMATEKSRVAGIKTEFFAINDDVGVGREKGGKVGRRGIGGGVLILKMVGALAEAGGSLDDLYALAQLANANLVSLGSSLEHVHVPGRGVPEDTIPHGEVEVGMGIHNEPGSHRVKFDLVELVRGMLLQLLDHNDPDRCYVTRKPEDQFVLLINNLGGVSPLELAGITDEVYRQLQHDYQVNMVRVIQGTFLTSLNGLGFSISLMKLVDPGLGVKTTMLELLDAPAEAVGWSAPISASTWENNRNAAPVDLKTSNLTEDIHSNLQLDPTILQKILGAGLQRVIDAEPEVTRYDTIVGDGDCGVGLKRGAEAIQSFLADASPPLTTDIVSTVARIVIVVENVMDGTSGAIYAIFLNALAHSLLAQNTTSPTAITTETWAKALKSSFAALGKYTPAKPGDRTLIDALSPFVDSLLESGDVRVAAEAARQGTESTKDMKASLGRSVYVGGEEEWLGKIPDPGAFGLSQFLTGLAEAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W6PXS5</accession>
    <name>W6PXS5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S01g002859</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PXS5"/>
    <dbReference type="STRING" id="1365484.W6PXS5"/>
    <dbReference type="OMA" id="HIIAPML"/>
    <dbReference type="OrthoDB" id="4453902at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM29048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="196" mass="22424" checksum="C07DC5C1A42C62E1" modified="2014-04-16" version="1">MEEDFVLERTKRRHALAEIEKLIKKSPNLHIEPSELKVAEDLPFPSKEEENELLEQKPNLDFIMWEARATESFLTSNFGDCLSYASDKYPHNPPPSGQYRDEANGDGRLLRGEIMTITGIMVGRLRSKRLRPHVVAPMLVLSLMGHCHARVLEADFDGKILNIRASKLYDFTQKNTEFVHSLTRYWLGGACGKIEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W6PY87</accession>
    <name>W6PY87_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S01g002527</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PY87"/>
    <dbReference type="STRING" id="1365484.W6PY87"/>
    <dbReference type="OrthoDB" id="5327538at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM28716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="153" mass="18808" checksum="F493F8FE78BFFDE9" modified="2014-04-16" version="1">MNCRTYIVIFSSTYSECNNTLERGQVSWRLNRLLVLDSIGDYNLFATVWKSAYGPEQGLGQYFLRQRRLPHYNRLHNEYQQVDRPLWKIERDEKDYFRKDFRNTIAKKLTLVSEWKTQYTHNDLLRLRKDMFIASPKMWKWIQQFIQDWEEMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W6PYI3</accession>
    <name>W6PYI3_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transcription factor, MADS-box</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PROQFM164_S01g002896</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PYI3"/>
    <dbReference type="STRING" id="1365484.W6PYI3"/>
    <dbReference type="OMA" id="SARADWI"/>
    <dbReference type="OrthoDB" id="4361034at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1810.10">
        <property type="entry name" value="Transcription factor, MADS-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002100">
        <property type="entry name" value="TF_MADSbox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036879">
        <property type="entry name" value="TF_MADSbox_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00319">
        <property type="entry name" value="SRF-TF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00432">
        <property type="entry name" value="MADS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55455">
        <property type="entry name" value="SRF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50066">
        <property type="entry name" value="MADS_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="MADS-box" evidence="7">
        <location>
            <begin position="18"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="10"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM29085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="110" mass="13027" checksum="2CACDF53A1D7073A" modified="2014-04-16" version="1">MPMAPSSELISKITAKHENLRARAQKLRRRRKGLFKKAAEYSIYCESDVVVAVRNRQSGQLYIFESSKKKWLPAEKDEHHYYPRPIRETLEDIIPGWERVEEEELRADVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>W6PYP1</accession>
    <name>W6PYP1_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Phospholipid-transporting ATPase</fullName>
            <ecNumber evidence="19">7.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">PROQFM164_S01g000888</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13 19">
            <text>ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.</text>
            <dbReference type="EC" id="7.6.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-L-serine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38567"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:38568"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66132"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:66133"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 18">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
            <location evidence="2">trans-Golgi network membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="19">Membrane</location>
            <topology evidence="19">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 19">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.1" evidence="19"/>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1365484.W6PYP1"/>
    <dbReference type="OMA" id="MHSFWSW"/>
    <dbReference type="OrthoDB" id="377733at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090556">
        <property type="term" value="F:phosphatidylserine floppase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006892">
        <property type="term" value="P:post-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02073">
        <property type="entry name" value="P-type_ATPase_APLT_Dnf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000026">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000047">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000010">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006539">
        <property type="entry name" value="P-type_ATPase_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032631">
        <property type="entry name" value="P-type_ATPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032630">
        <property type="entry name" value="P_typ_ATPase_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01652">
        <property type="entry name" value="ATPase-Plipid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092:SF150">
        <property type="entry name" value="PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092">
        <property type="entry name" value="PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16212">
        <property type="entry name" value="PhoLip_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16209">
        <property type="entry name" value="PhoLip_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 17 19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 18 19" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 17 19" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 19" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="498"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="548"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1100"/>
            <end position="1122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1143"/>
            <end position="1167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1179"/>
            <end position="1196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1208"/>
            <end position="1231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1251"/>
            <end position="1270"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase N-terminal" evidence="21">
        <location>
            <begin position="235"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase C-terminal" evidence="22">
        <location>
            <begin position="1029"/>
            <end position="1281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="36"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="52"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="active site" description="4-aspartylphosphate intermediate" evidence="16">
        <location>
            <position position="612"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="612"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="612"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="613"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="614"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="614"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="707"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="748"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="771"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="804"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="885"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="886"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="887"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="977"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="983"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="1003"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="1006"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="1007"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="1007"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00051303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU362033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF16209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF16212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="CDM27079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="1359" mass="152695" checksum="1E49D2FE0D86801E" modified="2014-04-16" version="1">MASGRPPGSHPAAGRDDDLLLDPGPEYNSGQGPPVNDEHLLERYNIDDSEEPYTQTQPRPSVSYDNFVGSSAQQGATQQNAPSRPAHPPANIGLHSNDPYSSGMRDRSYSQTSGLDNYRRYSLDDFDDGHSGYYDLDADEERIASSHHVRKANERNSVLGLGGGLMGKAKYMFGMGSSQYSEMDLPLTESGARRGTVGSDASPAPPPKQRKKFHVSDLNIFARKVDPSTLGPRMIQLNNPPANATHRFVNNFVSTAKYNIFTFIPKFLFEQFSKYANLFFLFTAVLQQIPNVSPTNKFTTIVPLAIVLAVSAIKELVEDYKRRMSDRGLNYSKTQVLKGSSFHDAKWVDVVVGDIVRVESEQPFPADLVLLASSEPEGLCYIETANLDGETNLKIKQAIPETAHLVSPSDLSRLSGRVRSEQPNSSLYTYEATLTMNAGGGEKELPLAPDQLLLRGATLRNTPWIHGIVVFSGHETKLMRNATATPIKRTAVERTVNIQILMLVSILIVLSVISSVGDLAIRRTRSSSLAYLDYGSVKVVKQFFMDIFTYWVLYSNLVPISLFVTIEIVKYFQAFLINSDLDIYYDKTDTPAICRTSSLVEELGQIEYIFSDKTGTLTCNMMEFKQVSIAGIQYGDDVPEDRRAAMEDDAEVGIYDFKKLRENLQSHPSQNAIREFLTLLATCHTVIPERNSDDPNVIKYQAASPDEGALVDGAASLGFRFTNRRPRSVIFEAGGQELEYELLAVCEFNSTRKRMSTIFRCPDGKVRVYCKGADTVIIERLHPDNPTVEATLQHLEEYASDGLRTLCLAMREVPENEFQQWYQIYDKASTTVDGSRADELDKAAELIEKDFYLLGATAIEDRLQDGVPDTIHTLQTAGIKIWVLTGDRQETAINIGMSCKLISEDMTLLIINEESSEATRDSLQKKMDAVQSQIVSGDSEPLALVIDGRSLTFALEKDMEKLFLDLAVICKAVVCCRVSPLQKALVVKLVKRHKKALLLAIGDGANDVSMIQAAHVGVGISGVEGLQAARSADVAIGQFRFLRKLLLVHGAWSYSRISRVILYSYYKNITLYMTQFWYSFQNAFSGEVIYESWTLSFYNVLFTVLPPFAMGIFDQFISARLLDRYPQLYQLGQRGVFFQKHSFWAWILNGFFHSLILYIVSQLLFYWDLPMADGQVAGHWVWGEALYTAVLGTVLGKAALITNIWTKYTFIAIPGSMALWLIFLPAYGYAAPALGFSREYYGTIPVVFKSPIFYLMAIVLPCICLLRDYAWKYAKRMYYPQQYHHVQEIQKYNVQDYRPRMEQFQKAIRKVRQVQRMRKQRGYAFSQADDGGQMRVLSAYDTTRSRGRYGEMASSRPMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W6PZV7</accession>
    <name>W6PZV7_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S01g001300</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PZV7"/>
    <dbReference type="STRING" id="1365484.W6PZV7"/>
    <dbReference type="OMA" id="HERAKSD"/>
    <dbReference type="OrthoDB" id="5327538at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF37">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM27489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="346" mass="39601" checksum="1906F4BB4E56DCD9" modified="2014-04-16" version="1">MNGSFNWAVTVQFEDDGEWIMRSPRSDYGQFPSELSGRLLANEASTLKYLGKVTDIPIPEVYSYRECMSRGHILHERYSLDEVPRGPFATESEFYNSLITAVLHHAEPLPLTPHCFVAPIPSREDYENDTAHQDACDLWNGFVAIGDRIDSAENRLDYIIVGDSLKDIMAQRTTGYLTHSLPDPFPLHHPDSNAGNIFVDDDFNITSIIDWSFCSSVPLAILLAPPGLPQSRYALGKDLIKVFREGYKETSRLKCHIERQSFLSSDALAILEDSEFSWSLIRLLTFESTDDLRLFRTLWNTVHTPDCDLESFIISQRHLPHYVRLYEKMQVEDRHIAEHQMAKGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2024-10-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q0X2</accession>
    <name>W6Q0X2_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S01g001660</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q0X2"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM27849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="117" mass="13375" checksum="AD96E415DEB23376" modified="2014-04-16" version="1">MFRMTNYNPAAGSEAYSGNLFHWRECIVSMQASNFHGTQIMAFAFSFLLCPTSLVNRSKETVDPKLKNKMKPDDWPVVLNRSRIDEKSPSIRDSRHLPLGFGDHSDNLVELTVMRNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2024-10-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q145</accession>
    <name>W6Q145_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S01g001750</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q145"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM27939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="52" mass="6177" checksum="E8C5CCDAB39CB4BC" modified="2014-04-16" version="1">MPRVHKADTWKFLRNLDSVGLNLNLNLKIVEYLQEHLTMVSLLIYQLFTPSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q225</accession>
    <name>W6Q225_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PROQFM164_S01g002050</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the paxB family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q225"/>
    <dbReference type="STRING" id="1365484.W6Q225"/>
    <dbReference type="OMA" id="CQLLCRG"/>
    <dbReference type="OrthoDB" id="5294024at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039020">
        <property type="entry name" value="PaxB-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42038">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42038:SF2">
        <property type="entry name" value="TERPENE CYCLASE AUSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25129">
        <property type="entry name" value="Pyr4-TMTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="22"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="138"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="205"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM28239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="243" mass="27242" checksum="EF1AE0308BB79D69" modified="2014-04-16" version="1">MDGFDPSQAPIEYQAVKPLADLFLLGAALGWVTNYVGMVYTSFNEETYAMSILALCCNFAWEIVYTLIYPSKNRLERGVLFLAMIINFGIMYAAVIFSPREWTHAPLVEQNLHWIFSIGIIGFLTGHLALAAEIGAALAYTWGAVVAQLLLSVGGICQLLCRGSTRGASYALWFSRFFGSCSAMGFAILRWMYWPESFAWLSSPLILWSVAVFLIVDGSYGLCYWYVKRYEKSFGTARTEKVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q2T3</accession>
    <name>W6Q2T3_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Kinase</fullName>
            <ecNumber evidence="4">2.7.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PROQFM164_S02g000790</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the inositol phosphokinase (IPK) family.</text>
    </comment>
    <dbReference type="EC" id="2.7.-.-" evidence="4"/>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1365484.W6Q2T3"/>
    <dbReference type="OMA" id="SPTAHQW"/>
    <dbReference type="OrthoDB" id="2573163at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000824">
        <property type="term" value="F:inositol-1,4,5,6-tetrakisphosphate 3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008440">
        <property type="term" value="F:inositol-1,4,5-trisphosphate 3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032958">
        <property type="term" value="P:inositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.160">
        <property type="entry name" value="Inositol polyphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005522">
        <property type="entry name" value="IPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038286">
        <property type="entry name" value="IPK_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12400">
        <property type="entry name" value="INOSITOL POLYPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12400:SF21">
        <property type="entry name" value="KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03770">
        <property type="entry name" value="IPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="188"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="459"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="585"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="694"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="767"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="829"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="909"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="997"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1175"/>
            <end position="1195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="56"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="78"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="225"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="250"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="304"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="337"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="467"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="697"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="716"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="727"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="829"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="858"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="923"/>
            <end position="939"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDM30640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="1299" mass="144389" checksum="6875B71945DA1A8C" modified="2014-04-16" version="1">MSNSPSVPEDTLPSPLVTPATPAQHDCSNIIGGGPRHHLPQAHLSRGSGEVLSPSRAESPTAHSWSQPVSRIFPLKRTATTPPENTAQPDIVYRPQLSERDSIFATHYLPSDSAATTPQLPPEKALGNERQVNLIPSLDDASVSPSAFSKVSPHRYSVDPSRMEVDVHRTSPLRSSTLFSSTDLPRLSLLRTPTSPTGRSKKTEVETGAPPHLAGSQRYKVPWDNTGTKTSRFQGTLPERKLFPSALDDVSTSHSLTIPTSGHEGSQISQDPLSYSAKEEKPQTPVVLERSPSRGRRGRVDSSIEANFTNPEPASNVRSRKSSHYLGLFKENTASSPDRKRREDRGRPQDETLESRDRIMEHEQESYRSEQETSLHKSTSLSALGDAPSFQPPPAELSQSTYDDDPSKRGPTALPRSLLEEIRNFHLTPGGSHGSSFSRSIPTQYSERARDYFQSDLHAEVSPSNSFEEEERGQVEEEENEQISSAVYFPHERTVPDGVEGLQQFPDSPLHVQPGQLSAAEKGHELMLVPQERSDSPKKEISHVDISFRSKNESKILYGDIHSQRENVPEKPLSTISECSDSIYDSEVEPQSADESIPSADEVETPSATPTQPSRLLSRPKPPPPGPLGAVELKPYRHQVGGHTTVFRFSRRAVCKQLNNRENEFYERIELRHPDMLVFLPKYIGVLNVTFSKTSKRKDQVDSADKIIPDPTANGTSTPSSEPPESAKQQPPQRIVSQSQVTGVIPKVILENNRHIIPADLFTRQQRPRTADASMSRARSVDGLKGMSAESDTSPMSKRAKIWGATTVNLKLQEQVLREVFSPPAIHHHRRHARGHVHLPRANSDMPGATHRRENLSEDCTATNQRPVPSPVAALKTEAIDIKVTPSEGSALSSSASTALEANQNRLEKIRTEEPDRASSLSRVHHPRRRHSGSGLRRRGTMDSNNNGELMFFDDDDYGGDKEDGIFSMEADASMSNGSSTVPVSENNSTNGGHATEAAFGRTSDPTRFKPQEPIDTILPSNPKEAQLRKDERVQFFLLLEDLTAGMNKPCVLDLKMGTRQYGIEANEKKKKSQRRKCQSTTSQQLGVRLCGMQSWNVKKQEYMFEDKYFGRDLKSGREFQDALTRFLYDGVSYASVAKKIPVILEKLALLEHMIRQLSSYRLYASSLLILYDGEPQSPPQQEPPRSNNGNHADGQSKLNVQLKIVDFANCITGEDKLPPDTPCPPHSPHDIDRGYLRGLRTLRMYFQRIMKEVSLDEFVERGEGEAIALGSQPEARERPSSQYWDETMIETDAGEVSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q334</accession>
    <name>W6Q334_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S02g001143</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q334"/>
    <dbReference type="STRING" id="1365484.W6Q334"/>
    <dbReference type="OMA" id="PEWRWPL"/>
    <dbReference type="OrthoDB" id="4305396at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM30993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="199" mass="22980" checksum="11CE19F67F5EB847" modified="2014-04-16" version="1">MTPTRSRRTIRPHWPPGITKKNAAQRIFNIPELVSETSRGIGGKKQWVWLAKFRPWKIGLGAKWEPYVEGQAGYLYRFATLNRALYTKIIQRQRTWKNTMGAMDTPAVSRSLDVIFAKVPAGFRPTGELVTVLSLSSYGRREPEWRWPLHGLPEDWAKLFRRISVLFLNLEKVEIGHNVLVADKVVKNFARRYPAPKDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q3D7</accession>
    <name>W6Q3D7_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Oxoglutarate/iron-dependent dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S02g000965</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q3D7"/>
    <dbReference type="STRING" id="1365484.W6Q3D7"/>
    <dbReference type="OMA" id="RDRNEFY"/>
    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044283">
        <property type="term" value="P:small molecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.330:FF:000045">
        <property type="entry name" value="Oxidoreductase, 2OG-Fe(II) oxygenase family, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="3">
        <location>
            <begin position="193"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM30815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="363" mass="40670" checksum="D7802F6496327081" modified="2014-04-16" version="1">MQSQIDQKDIPSNFPGIPAFPDDVSTAPLLRLSSGKLLAGDHTEQERLFQASTDIGFFYLDLSDSKRGLSLLGDADNLFQVGKRLFELSLEEKKQYDFSAQNSYFGYKAQGAMVVDKQGNPDRNEFYNVSKDDILGVSDPLPAPETLHKSRARLESFMQGSHAIVTLILDILNDKLALPKNTLSNMHRLRTVSGDQVRFIKAPPQPLDDRRTALGQHTDFGSVTVLFNRLGGLQVLPPGADAEWVYVRPLPGHAIVNLGDAMVKFTNGLFRSNIHRVVAPPGLQAESTRYSLVYFARPEDSVMLRRLEESDRIPVMEDGQTEEVINSKDWIIRRALGRRVDRVDDLDYEKSAGTEQLSRRIKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q482</accession>
    <name>W6Q482_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Zinc finger, CCCH-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S01g002775</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q482"/>
    <dbReference type="STRING" id="1365484.W6Q482"/>
    <dbReference type="OMA" id="AGCHDTG"/>
    <dbReference type="OrthoDB" id="2270193at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057683">
        <property type="entry name" value="DUF7923"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057654">
        <property type="entry name" value="Znf-CCCH_tandem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37543">
        <property type="entry name" value="CCCH ZINC FINGER DNA BINDING PROTEIN (AFU_ORTHOLOGUE AFUA_5G12760)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37543:SF1">
        <property type="entry name" value="CCCH ZINC FINGER DNA BINDING PROTEIN (AFU_ORTHOLOGUE AFUA_5G12760)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25540">
        <property type="entry name" value="DUF7923"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25542">
        <property type="entry name" value="zf-CCCH_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25543">
        <property type="entry name" value="zf-CCCH_tandem"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="3">
        <location>
            <begin position="290"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="1">
        <location>
            <begin position="290"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="317"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="317"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM28964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="519" mass="58138" checksum="AE139BD6262A3895" modified="2014-04-16" version="1">MLRDSDIDSLNGHLLSLSREQQKQHDNLQDLLSQFKSLLDDYSSLKSDYEEVKEGREKYKRQARGQDRNPFVLVLVDGDGYLFKEHFLKHGSEGGINAARELSDSIKELMHSTMGMQAEQCRIMVRVYANVLGLSKALARAGLMGHEARSMSPFTSSFTRAQELFDYVDAAEKKEGSDFKIREMFRLFVELNQCRHIYFAGCHDTGYGSLLTPYRGRGDRITLIKAAGFHREFEDLDLPIRELPSVFMSTPLLNSKPPTGPAASPTVAKFNGENSAHYVSNGTNGANGANTTKPICKHFQKGICKFGIGCNKQHVMPNQSLNHQPSPKHSGAGDSPKQLWSSPTVVGRSEDFFRSMLPLPSIKTEEFIPVNKDGDRIDPYYPHPSPEAFDQYHARAKEHKVCNSYHLSGECGDMSCTYDHSDVSEVIIEVLRYMLLQHPCTRGGACRSIKCYMGHLCQKPGCKAVKSWQCRFNQAAHTLDLQTARWDVPSDQSEIDQWSVSDGSIGKRSSPIGFSGFAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q4B7</accession>
    <name>W6Q4B7_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Replication protein A, subunit RPA32</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PROQFM164_S02g001618</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the replication factor A protein 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q4B7"/>
    <dbReference type="STRING" id="1365484.W6Q4B7"/>
    <dbReference type="OMA" id="SFGNKRY"/>
    <dbReference type="OrthoDB" id="25571at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005662">
        <property type="term" value="C:DNA replication factor A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04478">
        <property type="entry name" value="RPA2_DBD_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000308">
        <property type="entry name" value="Possible replication factor-a protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040260">
        <property type="entry name" value="RFA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014646">
        <property type="entry name" value="Rfa2/RPA32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014892">
        <property type="entry name" value="RPA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13989">
        <property type="entry name" value="REPLICATION PROTEIN A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13989:SF16">
        <property type="entry name" value="REPLICATION PROTEIN A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08784">
        <property type="entry name" value="RPA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036949">
        <property type="entry name" value="RPA32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Replication protein A C-terminal" evidence="7">
        <location>
            <begin position="171"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM31468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="278" mass="29026" checksum="8BF8AC5643973056" modified="2014-04-16" version="1">MDGSYNNYSSSFGGGGGFMPGEANSPAGGKTGDRDNKTLRPVTAKQVLDASQPFPEAPFQIDGADVANVLLMGQIRNISSQSTNVTYKIDDGTGEVEVKKWVDSATADSMDTDDGKAPADGKTEVELNGHARVFGSIKSFGNKRYIGAHSVRPLTDINELHTHLLEATAVHLFFTRGPPGGGGGAAAGNAGGVDAVMGGADDYGAGQNKALASMSLVAKKIYNLLKTEPQDDTGLHMQVIASKLNMPASEVGRAGEELLGAGVIFSTMDEQTWAILEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q4G5</accession>
    <name>W6Q4G5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S01g002875</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q4G5"/>
    <dbReference type="OrthoDB" id="4329476at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM29064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="137" mass="15524" checksum="BCB65FCACB243406" modified="2014-04-16" version="1">MVKYNTSDVIKAQMAELNDLVKEIAVLDSEMTNAASHKWIGLCQERMRKTSRMETLKEQIQCKIMAMDVHRKKTLTRQLNAITKVRGWTIDAYKSNNTKTTTAGTAPEVLKHGNEEECTNSTLSDDWVVAKDMNSCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q536</accession>
    <name>W6Q536_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Zn(2)-C6 fungal-type DNA-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PROQFM164_S02g001615</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q536"/>
    <dbReference type="STRING" id="1365484.W6Q536"/>
    <dbReference type="OMA" id="KEATCVD"/>
    <dbReference type="OrthoDB" id="5575144at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050335">
        <property type="entry name" value="ERT1_acuK_gluconeogen_tf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47659:SF4">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47659">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="145"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="14"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="466"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM31465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="508" mass="55165" checksum="9F0CDC06ACAD927E" modified="2014-04-16" version="1">MHSLVLHPPSLTISQFGQPRFNQGPERLPLNRSWTPNARGCSPRAPIPHQSMSGSPPAKPSELSAEIPRGYPPSLGFTERSAVPVLELSQIPVNEPLSRGYNEQGPVYAGSPLLAGAPTLDPTHPTGRSLAQKSTRRTKAHVASACVNCKKKHLGCDPARPCRRCVLAGKASTCVDVTHKKRGRPPLKAEDSSVKSYTTHLDNPAVPAEAQPTMPPRRTAMHRATSSRELRPMTDLQGLGDVSSGIRTPHRWSASVFPLTRPMDLSPNVPGMIRRPFSSSGPPSYSVPTHSHVPSPYMPMAGLNPVLKVNTMSGGMDRRFQTYGVPALPPPTSPPQHQPPPVGMPFLPYTETPGNPIRPTANDSRVSLSPRDPYTVESPVRLPPIHQATAGPPPPHHVHRLSDPYPMNWTLPGREEPLYDPRALPLHRSAGPVFNYPLPHQRSSSITSATMDPIPRHLGPVELPSPIQIASGHSPSLTRAEPPSMEAEGHDNRPIKRRKMALDDMVNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q5K3</accession>
    <name>W6Q5K3_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Adenosine kinase</fullName>
            <shortName evidence="11">AK</shortName>
            <ecNumber evidence="4 11">2.7.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Adenosine 5'-phosphotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">ADK</name>
        <name evidence="13" type="ORF">PROQFM164_S01g003311</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>adenosine + ATP = AMP + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20824"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenosine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the carbohydrate kinase PfkB family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.20" evidence="4 11"/>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q5K3"/>
    <dbReference type="STRING" id="1365484.W6Q5K3"/>
    <dbReference type="OMA" id="RTMCTYL"/>
    <dbReference type="OrthoDB" id="432447at2759"/>
    <dbReference type="UniPathway" id="UPA00588">
        <property type="reaction ID" value="UER00659"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004001">
        <property type="term" value="F:adenosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044209">
        <property type="term" value="P:AMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006144">
        <property type="term" value="P:purine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01168">
        <property type="entry name" value="adenosine_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1190.20:FF:000014">
        <property type="entry name" value="ADO1p Adenosine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001805">
        <property type="entry name" value="Adenokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45769">
        <property type="entry name" value="ADENOSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45769:SF3">
        <property type="entry name" value="ADENOSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00989">
        <property type="entry name" value="ADENOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 11 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 11" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="12">
        <location>
            <begin position="27"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601805-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDM29499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="349" mass="37969" checksum="F654261DCAB23569" modified="2014-04-16" version="1">MAAAQGYPLLCLENPLLDIQARGDAALLEKYDLKPNDAILAEEKHMGIYEDLLARDAKLIPGGAAQNTARGAQYMLPENSVVYIGCIGKDKYGEILKKTCEEAGVHTEYRIDETQPTGKCGVVITGHDRSMCTHLAAANEYKLEHLKQPEVWSLVEKAQHYYVGGYHLTVCVPAILALGEEAAAKNKTFMLSLSAPFIAQFFKDQLDSVLPYTDYTFCNETEAIAYSEGHQWGTEDITEIAKKLAQLPKKNTQRPRVAIVTQGTLPTIVAIGSATGDVEVKEFKVREISKEAINDTNGAGDAFAGGFCAGIVAGKSLDDSIDMGQWLASKSIQELGPSFPSPKQTYSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q6B6</accession>
    <name>W6Q6B6_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Vacuolar protein sorting-associated protein 28</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">ESCRT-I complex subunit VPS28</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">VPS28</name>
        <name evidence="9" type="ORF">PROQFM164_S02g001706</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the ESCRT-I complex (endosomal sorting complex required for transport I), a regulator of vesicular trafficking process.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Late endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the VPS28 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q6B6"/>
    <dbReference type="STRING" id="1365484.W6Q6B6"/>
    <dbReference type="OMA" id="CDEFPTV"/>
    <dbReference type="OrthoDB" id="2671at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000813">
        <property type="term" value="C:ESCRT I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1440.200:FF:000003">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1130:FF:000001">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 28 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037202">
        <property type="entry name" value="ESCRT_assembly_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007143">
        <property type="entry name" value="Vps28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017899">
        <property type="entry name" value="VPS28_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037206">
        <property type="entry name" value="VPS28_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017898">
        <property type="entry name" value="VPS28_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038358">
        <property type="entry name" value="VPS28_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12937">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING 28, ISOFORM 2 VPS28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12937:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 28 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03997">
        <property type="entry name" value="VPS28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017535">
        <property type="entry name" value="VPS28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140111">
        <property type="entry name" value="Endosomal sorting complex assembly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140427">
        <property type="entry name" value="VPS28 C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51310">
        <property type="entry name" value="VPS28_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51313">
        <property type="entry name" value="VPS28_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0967">Endosome</keyword>
    <keyword evidence="4 5 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="VPS28 N-terminal" evidence="8">
        <location>
            <begin position="21"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="VPS28 C-terminal" evidence="7">
        <location>
            <begin position="150"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR017535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM31556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="244" mass="26972" checksum="E3437018E6CFBF2E" modified="2014-04-16" version="1">MYSQRPLSYAPTPYSYTPNPARSATINLDEEVKLASSAVERDLYESLAEIYSIIVTLDGLEKAYIKDVVTEAEYTETCTRLLKQYKSSIGDETVSREFVDLETFKRTWGLECPRATERLRIGLPATVEQASHGGPTPSMGATATGQAGGASGSLILAATENFITFLDALKLNMVSKDALHPLLSEVIQSVNKVTDTDFEDRGKIIQWLIALNQMRATEELSEDQARELAFDIEQAYQGFKATLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q6Y6</accession>
    <name>W6Q6Y6_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ribosomal protein L22/L17</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PROQFM164_S02g002271</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL22 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q6Y6"/>
    <dbReference type="STRING" id="1365484.W6Q6Y6"/>
    <dbReference type="OMA" id="QRQYYSW"/>
    <dbReference type="OrthoDB" id="416470at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00336">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.470.10:FF:000017">
        <property type="entry name" value="54S ribosomal protein L22, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.10">
        <property type="entry name" value="Ribosomal protein L22/L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001063">
        <property type="entry name" value="Ribosomal_uL22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047867">
        <property type="entry name" value="Ribosomal_uL22_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036394">
        <property type="entry name" value="Ribosomal_uL22_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13501">
        <property type="entry name" value="CHLOROPLAST 50S RIBOSOMAL PROTEIN L22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13501:SF10">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL22M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00237">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54843">
        <property type="entry name" value="Ribosomal protein L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="49"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="49"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="99"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDM32120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="332" mass="37499" checksum="24010F81E94DBCAD" modified="2014-04-16" version="1">MVYRSGQLVRTAVRTVSFVPRRTLTTTAIRYAVKDSESKKPTGLFSSLKNLFTGGSNQKPKVTHRPSAPKKEEGTLATSIFGSDLAAPASGPMPSRATGEQKEGISGKLEDRDLSRLQVGLAPDPRAQLRWDRKMAVREIRKRGRVPTKVQIKRTERESLSRSHWIKTSLKKLGPLARQIAGKNIDEAILQMRFSNKKAAKDVLEHLEHAKNVAIVRAGMGLGASGSEPTKPITVILKTGERQKIANPSDIYIQEAWVNRGPYGYEMDHRARGQINRMRPPTTSLSVLLKEEKTRIREWEDREAKAQRERRAQLWTQLPDRKISAQNQYYSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q734</accession>
    <name>W6Q734_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Taurine catabolism dioxygenase TauD/TfdA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PROQFM164_S02g001917</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TfdA dioxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q734"/>
    <dbReference type="STRING" id="1365484.W6Q734"/>
    <dbReference type="OMA" id="HYQPAFN"/>
    <dbReference type="OrthoDB" id="10257314at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051323">
        <property type="entry name" value="AtsK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT SULFONATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468:SF10">
        <property type="entry name" value="TAUD_TFDA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="8">
        <location>
            <begin position="47"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="22"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM31766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="369" mass="41458" checksum="908ACA4978F24D5A" modified="2014-04-16" version="1">MSPAITTQDHAEDLDIKAKATDTPQPSILRSPLKSSGSLNEYENFNTTPIIGTEFPRVQLTDILKDEAKIRDLAILVSERGVVFFRDQDISSEEQKVLGQKLGELTGKPSTSKLHRHAVANSKRGIAVDENGHLDDEISVISSEVNRKLYGDRYKPLNGRLASQGWHADITFERVPSDYALLKITDLPEDQSGGDTLWASGYELYDRLSPSIQKLAEELKVVHYQPAFNKIAKEHGIDLIEGDRGAPENTGFDFKATHPLIRTNPVTGWKSLFGAGQQVEHGWIEGVTQLESEVLKKLFNRLLFENHDLQVRFRWGRNDLAIWDNRSVYHTATNDYNGKRQGNRVVSLGEIPYFDPLSKSRRQALAEGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q7P0</accession>
    <name>W6Q7P0_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S02g002541</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q7P0"/>
    <dbReference type="OMA" id="AETNEAH"/>
    <dbReference type="OrthoDB" id="5364312at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42111">
        <property type="entry name" value="YALI0D23727P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42111:SF1">
        <property type="entry name" value="YALI0D23727P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="64"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM32390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="308" mass="32957" checksum="402235B39F82286C" modified="2014-04-16" version="1">MSDIEMSRFAAQTEKPNEAEASTRAKPTALTWDNQSDKGCISPVRSFEGLRTPNHDSPKYMRHPSSPESSSYLPSRIHSPASQIFERDVEDIVPAQASPSIPTHIRTDNYIPPVLEASSAAITDDHLDPDSVEIVTHSLHQPAGGPSGEQSMSSSSIDHLLGQLDGDELTSSYGALDTADVRRLSFISFADVVNAEHAETNEAHAGLISRGRLADFNQSPSPLRSPSSSRGLGTSPPTSRATSFRGLDMSPTRFPTSSVAQSPISSSFGGDLNIETMRQALRKTASGDLGVTSRAVSTIGDDLLDRTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q893</accession>
    <name>W6Q893_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Alpha-ketoglutarate-dependent sulfonate dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">JLP1</name>
        <name evidence="8" type="ORF">PROQFM164_S02g002352</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TfdA dioxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q893"/>
    <dbReference type="STRING" id="1365484.W6Q893"/>
    <dbReference type="OMA" id="YENAWHS"/>
    <dbReference type="OrthoDB" id="10257314at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.130.10:FF:000003">
        <property type="entry name" value="Alpha-ketoglutarate-dependent taurine dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051323">
        <property type="entry name" value="AtsK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT SULFONATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468:SF1">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT SULFONATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="7">
        <location>
            <begin position="96"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM32201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="379" mass="42470" checksum="C3EEBAA0557E84E1" modified="2014-04-16" version="1">MAPSLTETVGLRAPPVALPLKADGGFNKENLIGYKIEKDVEIKGTDKVAPVSYPEYLPVWDNETERYPPLTPFEHYDHGKDADPSFSELLPEGVQVDQLTPFIGSEIHGVQLSQLSDKGKDQLALYVAQRRVVAFRDQDFASLPIQKAVDYAGYFGRHHIHQTSGAPKGFPEIHLVFRGADDRTGETFLKQRTNTITWHSDVTFEKQPPGTTFLYALDGPTTGGDTLFADMVQAYKRLSPGFRERLHGLKAVHSGLEQIHASLNGGGIARRDPVSSEHPIVRTHPVTGEKALYVNPQFTRYIVGYKKEESDNLLKFLYDHIALSQDLQARIRWKAGTVVVWDNRVACHSAVFDWEDGQRRHIARLTPQAEAPYETPFEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q8B1</accession>
    <name>W6Q8B1_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S02g002367</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q8B1"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM32216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="127" mass="13614" checksum="1CC80A3689BFCBED" modified="2014-04-16" version="1">MGHPSHSLGIWSAFPCNLRGLLSRLPNDTKDSNPSHPAALVTSATYIYLGGAAAAPPITHHPSSFRWTFSAILSETQAEDINTLEVVNGPDRTQDVYPVTNSDNTPTRLGARTYLSKTKTTSTSTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q9H0</accession>
    <name>W6Q9H0_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription initiation factor IIF subunit beta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">TFIIF medium subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">TFIIF-beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PROQFM164_S02g003216</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TFIIF beta subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM33065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q9H0"/>
    <dbReference type="STRING" id="1365484.W6Q9H0"/>
    <dbReference type="OMA" id="ANCPEHQ"/>
    <dbReference type="OrthoDB" id="26094at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005674">
        <property type="term" value="C:transcription factor TFIIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07980">
        <property type="entry name" value="TFIIF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000035">
        <property type="entry name" value="General transcription factor IIF subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003196">
        <property type="entry name" value="TFIIF_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040450">
        <property type="entry name" value="TFIIF_beta_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040504">
        <property type="entry name" value="TFIIF_beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011039">
        <property type="entry name" value="TFIIF_interaction"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10445">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIF SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10445:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIF SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02270">
        <property type="entry name" value="TFIIF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17683">
        <property type="entry name" value="TFIIF_beta_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50916">
        <property type="entry name" value="Rap30/74 interaction domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="13" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TFIIF beta subunit N-terminal" evidence="12">
        <location>
            <begin position="46"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="TFIIF beta subunit HTH" evidence="11">
        <location>
            <begin position="257"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="325"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="342"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00081473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00081863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF17683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDM33065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="364" mass="42072" checksum="915A5C9BF46885FC" modified="2014-04-16" version="1">MAQVKQDPDRPYFKQDPDSKDIALRDIDEEDLYEDAGDLDFSQAGQNVWLSRLPRSLWEHWAHLDDDEEIELGTMRVEGTPNDIKRVSLRLHDRPDNREIPKDYTLQRQTVDPSGTGSHLTHNTYIFTEKDIPGVENRMATFGETRSVLYEAQKREAKRREQGKRWEPYVRKTIPKHTALAGAVSEEFNCLPVENEEFRRISEKRALEALKPRKETVFIDKIPGKIIQARHALPTERGQFVQATRPSKGKSQENKSTRMPQNELLDLIFQCFREFKYWPFKTLKARLAQPEAYLKQTLEMVAHLVKAGDFAMTWELKPEATHSQYSNAMDNAKAELPPGADDPYESEDDPASGIDQDDVQFENV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q9W0</accession>
    <name>W6Q9W0_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S03g000167</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q9W0"/>
    <dbReference type="OMA" id="PEALWPK"/>
    <dbReference type="OrthoDB" id="4364733at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM33443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="195" mass="21639" checksum="887D16F94C45B07D" modified="2014-04-16" version="1">MAKPQSVKRARSNTIGDAHNTTTPSWEEISQRVQTLDEQSIANILVYAAQIHPDIMNMVDHAIHRSSKQYEIAGDVVEEVVDTIESIAEECGPSVNPQTRFNGLSVLRKIGKTIALSTNDTLGREVQESFQSDSSLVDAMIKIINSMTADEVRAIREDNSSPTALWPKLQELEKLAETECIHPGLEEVLDLLYPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W6QAA8</accession>
    <name>W6QAA8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S02g003102</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QAA8"/>
    <dbReference type="OMA" id="ACALRYK"/>
    <dbReference type="OrthoDB" id="4239999at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM32951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="103" mass="11607" checksum="8333E5C93EBD06DF" modified="2014-04-16" version="1">MKFQDDGKGNLEYEHKEVSPFVKPLLRTVGLPNWNFTVWMWNTSFKWDKLPGPVNIIPICNISDSARSEPGGAFKHGLMRRIDGDVTVEPRLAAIFAVPPIIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W6QAK8</accession>
    <name>W6QAK8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Phosphatidylinositol-glycan biosynthesis class S protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PROQFM164_S03g000189</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM164</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PIGS family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QAK8"/>
    <dbReference type="STRING" id="1365484.W6QAK8"/>
    <dbReference type="OMA" id="AEHKYAV"/>
    <dbReference type="OrthoDB" id="28748at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042765">
        <property type="term" value="C:GPI-anchor transamidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016255">
        <property type="term" value="P:attachment of GPI anchor to protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019540">
        <property type="entry name" value="PtdIno-glycan_biosynth_class_S"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21072">
        <property type="entry name" value="GPI TRANSAMIDASE COMPONENT PIG-S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21072:SF13">
        <property type="entry name" value="GPI TRANSAMIDASE COMPONENT PIG-S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10510">
        <property type="entry name" value="PIG-S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="531"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDM33465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="567" mass="61450" checksum="DFAC18852B854EFE" modified="2014-04-16" version="1">MTTKTGDQESPQASSSQGDQLSVKRAPPPETPAALQTRFRVIAAFWAVIIFLGFPIWWKTTSIYRASLPIEEMVDWADGKACRPVFPLDIHLATPSMQSFEAQHLLRTTQHTLDDLNEFAAHHLRLKLTNGTTTAVHNGEDNLEYPAKETADTALTVRLLPQDGLASPWSELHAAATQLDIFYPPSQVPVPSSSNSPLSTFIAAELQQLYGEEKATIAHILSGNTAGLDSTSPQLAEDIDRRLRRSMKYAETYHLSFSLFTPGSEPSSWDIEAAVKEYVSPLLQALSPISNFTVDTQVQLYANFAPTAPKPEYDESEAAWTLKKEGLSAFVNAAEWPLNPSIGNGPTINFILYVPDPSQSPLIVKENRASSWIVPQWGGVFLLNPPLSNTGEQSAPSNPSHLSLDSLGPAFMTFSHQLLTLLGTPSTPASLPLRLQTSIRIRAASLLLSASSTMGSLARLTKSLPSIPIPATVATSVSTTLSHLSASCVHLREGRFGAALASARVAETEAERSFFEKSMVGQVYFPDEHKVAVYLPLLGPIGVPLVVGLLKELKRIAARRKANGAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W6QAV6</accession>
    <name>W6QAV6_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Non-homologous end-joining factor 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PROQFM164_S03g000324</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the XRCC4-XLF family. XLF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QAV6"/>
    <dbReference type="STRING" id="1365484.W6QAV6"/>
    <dbReference type="OMA" id="IKGVAPF"/>
    <dbReference type="OrthoDB" id="2155935at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032807">
        <property type="term" value="C:DNA ligase IV complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045027">
        <property type="term" value="F:DNA end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd22285">
        <property type="entry name" value="HD_XLF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.210.10">
        <property type="entry name" value="DNA double-strand break repair and VJ recombination XRCC4, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052287">
        <property type="entry name" value="NHEJ_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053829">
        <property type="entry name" value="XLF-like_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015381">
        <property type="entry name" value="XLF-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038051">
        <property type="entry name" value="XRCC4-like_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32235">
        <property type="entry name" value="NON-HOMOLOGOUS END-JOINING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32235:SF1">
        <property type="entry name" value="NON-HOMOLOGOUS END-JOINING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09302">
        <property type="entry name" value="XLF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21928">
        <property type="entry name" value="XLF_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XLF-like N-terminal" evidence="9">
        <location>
            <begin position="4"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="XLF-like coiled-coil region" evidence="10">
        <location>
            <begin position="123"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="252"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="275"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="339"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="491"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="576"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="609"/>
            <end position="628"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF09302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF21928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDM33600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="638" mass="69822" checksum="F329F711A0160BE3" modified="2014-04-16" version="1">MPSRWQRLHLSQQGIPPLLFQYTWTRQGYEIHITDLTYIWSERLPRKAITKRAEEDVTTIDPGEDQEQLDVLLETIGEALQNGNESAILSSGTQTNSLEIMTTTKLPSPLKPLKWSLKLLKEPLSSLTNTLLLPLLREEAEWESRQRLLLNQIKQKDYVLGKLFDKMETLGVDLGSVFPSAAGSRMSRKAITRSDAAKSVKGIAPFEEETWLAERGLSHRAGLATNLLHEISESGDSRALDTFTQSQGEWWQQLARPPETSAREASPIEEEISNDQDRTKPVEIKNIDTGADSTASSDDDEFQRQETPPRLKSQHGKGEALPPKQKPREKSPVPSVLPSEEDEATASDSESESEPAPRQRHIPSVSRSRGPAAPELKAREAQKVTKGGLGKIGGKNKKETERKPSPSPSPVPSPARVQEIPKVPKGGLGKIGGKNKKEPERRASPSPSPAPSPPAQVRETPKKPKGGLGMIGGKKKQAKEPSLSPAPSPPAQARDSPKSQGPPESPEQEERISRDPSLPISSIPVPATTKAKRPGKLGMIGGKAKAKAAEEARNKSPLPTSDTVVMSPEKATPAKPKADRQALKKEESPLPTSAKEKIPPAPPAEPETEDQRADRKREELKRSLEAKAKAPAKKKRRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W6QB18</accession>
    <name>W6QB18_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major facilitator superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PROQFM164_S01g000711</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QB18"/>
    <dbReference type="STRING" id="1365484.W6QB18"/>
    <dbReference type="OMA" id="SVFDWYP"/>
    <dbReference type="OrthoDB" id="6132182at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000065">
        <property type="entry name" value="Putative MFS pantothenate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF28">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="135"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="170"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="204"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="275"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="314"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="338"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="365"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="397"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="434"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="465"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM26902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="488" mass="55443" checksum="A68BC3C6B79A2EC5" modified="2014-04-16" version="1">MSDLKPKAGRLSPLGLFKEVFNWYPSSYPAEERKLLFKLDLSILIFACLCFFVKYLDQTNISNAYVSGLKEDFGLYGNELNYFNVCYFCSYVLFQIPGLLLMSRPKLARWLLPTLEVLWGICTFAQSRVTNVHQLYALRFLVGMLEAPVFAGTHFILGSWYTGPELFKRAGTWFICNPLGTMVSGYLQAAAYTNLSGVGGMPGWRWLFVIDGIFTIPVALLGFLIFPGIPGSPKPFYLTDRDIELAKERTKRAKIRQPGKMSLDVFKRTFKRWHIWVFITCYACMIICSYPSSYMSLWLKQEGYSVTQINQLPTVTYAINIVASWLGTTLAAIYPEWIIYTIASACCLFSTLCMIVWNIPTGLKFVAWYVFGAAGCLSPILYSTINVIVRDDAEERALIMGSMMTFGYSFNIWVPLLAYPTAGPDGAPRWRKGWPVSFVFFFLLWAGFVTSVYIWRREQRKQALVSPQESSDEETDTVVVDGTPTLKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W6QB66</accession>
    <name>W6QB66_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">F-box domain, cyclin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S02g003408</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM33256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QB66"/>
    <dbReference type="STRING" id="1365484.W6QB66"/>
    <dbReference type="OMA" id="EWEHIAG"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="293"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="269"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="275"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM33256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="419" mass="48366" checksum="AE53BCA37768DE41" modified="2014-04-16" version="1">MVEDLDYQPPKDIGDNDPYEYDSDYESTDSMSVDGEDARDNGDSEDSSTDTNQDPERKMYDHWVWQTFKRPGLTDDLLRVGFLDNPTGGYSVDAISPEQASGCRTAQFLVHNSLQRDTWKSDELHEPWEIDGDWSLSGICDGAPMDPIVFPKRNGLEYFEADDTFISQNIPPNEIAMPFHPWCFDIFCRQSKVQFQCINASGLMTWRNSEFDYDSRDSFPRCKEVKSSQKQWWFHQPGTEYLIANPLDVPGLPEILLAAVENQESDASYDPSYEIESSQSPTKRPVPSHNSQADFLSVLPAEIRLMIIDYLDSSDIASLTVASKAFTELPNTVWYRLVRREMPWLWEAWDESECIHSPSMWTNMQTAELKSMIRLRKFYVEGLLVDWYTERDAEKAAEHRYPMTVTMPDQVKLPIRNTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W6QBU8</accession>
    <name>W6QBU8_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ferric-chelate reductase (NADPH)</fullName>
            <ecNumber evidence="3">1.16.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PROQFM164_S03g000654</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>2 a Fe(II)-siderophore + NADP(+) + H(+) = 2 a Fe(III)-siderophore + NADPH</text>
            <dbReference type="Rhea" id="RHEA:28795"/>
            <dbReference type="Rhea" id="RHEA-COMP:11342"/>
            <dbReference type="Rhea" id="RHEA-COMP:11344"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.16.1.9"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ferric reductase (FRE) family.</text>
    </comment>
    <dbReference type="EC" id="1.16.1.9" evidence="3"/>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QBU8"/>
    <dbReference type="STRING" id="1365484.W6QBU8"/>
    <dbReference type="OMA" id="NNETQRY"/>
    <dbReference type="OrthoDB" id="4494341at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052851">
        <property type="term" value="F:ferric-chelate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000023">
        <property type="entry name" value="Putative ferric-chelate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051410">
        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361:SF24">
        <property type="entry name" value="REDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G10820)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <keyword evidence="6 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004879717" description="ferric-chelate reductase (NADPH)" evidence="14">
        <location>
            <begin position="17"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="40"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="199"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="237"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="267"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="15">
        <location>
            <begin position="317"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CDM33930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="596" mass="66732" checksum="3CB8629752A5FB1A" modified="2014-04-16" version="1">MHSFLLAMSLAGLTSATDIEYIEKRSGYSVYYEAINDSLARYTILALGCAAAAYYIWQLVFCFSRHLRRLASFNDDRQRYFVSTHNTFAWIKEHIIYAALFRNRHNLELQLSSAINMGTLPSRFHAFLITGVIAMNVTLCCVTTPYGTETDTLAGVIRNRTGVMATVNLIPLILMAGRSNPLIAMLHVPFDTWNLLHRWLGRIVVLESLAHVFAWAIPKAQAKGWKVVGMALGGSSFLLTGLVAACAFTALLLHSPSPIRHAFYETFLHLHIAITAVSMGFLWVHLNGLPAQAYLLAALILWALERATRFLIIVYRNCGRESTTATIEALHGDAMRITLRLARPWTFRPGQHIYLYIPAVGLWTSHPFSVGWSETADSHSDEKSLPLTSKDILNAPQKETISLLVRRRTGMTDKLFQRASNSPTSQITLRAFAEGPYGNIHTMDSYGTVMLFAGGVGITHHVPFVRHLVAGFANGTVAARRVTLVWIIQSPEHLEWIRPWMTSILAMDRRREVLRIMLFITRPRNTKEIQSPSATVQMFPGRPNIDTLVGMEVENQIGAMGVLVCGNGGLSDDVRRVCRKRQAQSSVDYVEESFSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W6QC20</accession>
    <name>W6QC20_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S03</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S03g000335</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QC20"/>
    <dbReference type="STRING" id="1365484.W6QC20"/>
    <dbReference type="OMA" id="HSQEFHY"/>
    <dbReference type="OrthoDB" id="5421421at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="303"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="128"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="303"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="337"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM33611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="346" mass="38758" checksum="E173FD69DCD6EF8A" modified="2014-04-16" version="1">MSNRSDIPFVEQMGEYYEGMPADWPMMPATPYVGCYSPDFAEPLAEPGMLMPLGVLGSSFHPGPEFGYHSQGYYADAHQHIINDPLSATVGLGISAPFPDNFPRSLAPSPDVYAPGPSGVQHGVTEAPSQSPQGSPQGSPAKRARHQSSDTSSSEQPSNAPINIAPNPEGVRRMEQDRQNVQPSSHVLPKPRAPGRGRRDPRAEYEDAFVEDLRDKKKAWKVVRLEFEEKFQKEASESRLQMRLHRRYRERKVRWATSDIELLLDAHRNWANDKFQYLSDKMKELGGTRWYSADQCRNQLRLIEAKEQHDRGSESPSVMSEPTPVTPAPVAPAPTVSRKRRRASDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W6QC57</accession>
    <name>W6QC57_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DASH complex subunit DAD4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Outer kinetochore protein DAD4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">dad4</name>
        <name evidence="17" type="ORF">PROQFM164_S03g000972</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DASH complex DAD4 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QC57"/>
    <dbReference type="STRING" id="1365484.W6QC57"/>
    <dbReference type="OMA" id="SQMWANY"/>
    <dbReference type="OrthoDB" id="5516652at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042729">
        <property type="term" value="C:DASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008608">
        <property type="term" value="P:attachment of spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013959">
        <property type="entry name" value="DASH_Dad4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28222">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28222:SF1">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08650">
        <property type="entry name" value="DASH_Dad4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8" id="KW-0132">Cell division</keyword>
    <keyword evidence="15" id="KW-0137">Centromere</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="9" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-0498">Mitosis</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00030569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CDM34248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="72" mass="8323" checksum="719191BF422EF9D1" modified="2014-04-16" version="1">MESPHEHQQTVLLSRIITNVEKLNEAIMVMNKGLQEVNIQNMNVELVAQMFKNYQSNVLFHLEATENLQDPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W6QCI4</accession>
    <name>W6QCI4_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Pheromone-regulated membrane protein 10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PROQFM164_S03g000919</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ThrE exporter (TC 2.A.79) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QCI4"/>
    <dbReference type="OMA" id="WYKKPPN"/>
    <dbReference type="OrthoDB" id="413008at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010619">
        <property type="entry name" value="ThrE-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051361">
        <property type="entry name" value="ThrE/Ser_Exporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024528">
        <property type="entry name" value="ThrE_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31082:SF10">
        <property type="entry name" value="DUF1212 DOMAIN MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_3G01440)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31082">
        <property type="entry name" value="PHEROMONE-REGULATED MEMBRANE PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06738">
        <property type="entry name" value="ThrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12821">
        <property type="entry name" value="ThrE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="417"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="442"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="498"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="541"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="583"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="608"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="631"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="663"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="714"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="domain" description="Threonine/serine exporter-like N-terminal" evidence="8">
        <location>
            <begin position="309"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="domain" description="Threonine/Serine exporter ThrE" evidence="9">
        <location>
            <begin position="589"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="74"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="113"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="147"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="187"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="226"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="256"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF06738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDM34195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="752" mass="81727" checksum="AB71121C9F48BD5F" modified="2014-04-16" version="1">MPYSHESEDIADTPQRDREPQSSETDSESGVQRIDQNKRPGGEKKEDEKKEHETSEQQSTLEKWRTATRNFRRKASEFGDRLGRPQAEGDDLTSGRYHADWATGGAPPLSDVTDDKHKSVEAKQRDQKGTSSEAHRLVRDLTQDHSQKRRKGRGKPYPHPDNEFKDEENETGADASLRYRSGGGGILSQLIKLQGGQQQGAGGQSRTSTDSSSSAESAPSGAPTPKPKKQKPVKWYKKPKNTSNSTLIGGGADSFSGASTPVSSEILSQASRRRDKEGGGGGGGGNRNMRLEDEIRVTVHIAEIICRQRYIMQLCKALMLFGAPTHRLEEYMQMTAKVLEVDSQYLYLPGCMIMSFDDPSTRTTEVKMVRVAQGVDLARLSDTHLIYKNVIHDVIGIEEAIQELDAVIKKKPIYHKFIVILVYGLATATVGPFAFSARPIDMPIIFLNGILVGLMQHVAAPRSVLYSNVFEVTSTVVTSFLARAFGSISLGVVNGKPQYLFCFSAIAQSSIALILPGFLVLCSSLELQSHQIIAGSIRMVYALLFSLFIGYGITVGTTIYGLMDNHAVSDTSCPDKGAFKNPYVQRFPFVAIQTVWLLIINQGKWKQLPPMIIIAMAGYISNYFSTKRLGSNSQVANTVGAFVIGIMGNLYSRLWHGHAATAILPGIFILVPSGLAATGSLISGVQSADEIRQSVGSHGSSSSAPGAGLQSNSIFSLGFGMIQVAIGITIGLFISALVVYPYGKARSGLFSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W6QCW0</accession>
    <name>W6QCW0_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S03g001014</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QCW0"/>
    <dbReference type="STRING" id="1365484.W6QCW0"/>
    <dbReference type="OMA" id="SYWQHIP"/>
    <dbReference type="OrthoDB" id="512662at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847:SF213">
        <property type="entry name" value="DEPENDENT OXIDOREDUCTASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847">
        <property type="entry name" value="SARCOSINE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="1">
        <location>
            <begin position="47"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM34290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="478" mass="52374" checksum="7A53378C59CDF171" modified="2014-04-16" version="1">MAPNDTVFSLVTADPGLPRPNPTESYWQHIPHALANVQSSKLPTDRDFAIIGSGITGLSVARSLLERHPTATVTVLEARTLCSGATGRNGGQMAANAGEQYMNLAEAHGVETAGKIVDFTFRNLEKMQELIEEYDAVELSEMQRLRKLRVFLTQGKFDDFKKSIARLEIDHPSKKGIYTILDADAVLKEYGIHGASGGTLLPAGTVWPYRLVTKVFAALLEKYPGRLTIETHTPVESVEHISTLAYPYTLHTSRGPLRARTVVHCTNGYSGHLLPHLRGLVYPFKGTMTVQDPQNAVPNQGTAVSWGFHYPPTYDPATQRLGFGLYYLGQSAKTGYFYFGGEHARFDESISADDSFVTDDSVKHLEDVLPRFFGKNDKSDWRLVSSWSGVMGYSPDGLPIVGRLSPEMTGRGGDGEWIAAAFNGYGMANSLLSGEALALMILGEDVSDWLPVSYGLGENRLRETLTVSRAVNGLRSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2024-10-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>W6QD02</accession>
    <name>W6QD02_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S03</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S03g001297</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QD02"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM34573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="76" mass="8713" checksum="A86F7FF435FA6319" modified="2014-04-16" version="1">MKELCEWARRTNSSLRKSGHSAKGRRRKHACSVLKWSRRTDSLQRRAGTSPLSFMVILMCVGEQTSNFGVKIHRPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W6QD37</accession>
    <name>W6QD37_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein family UPF0546</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PROQFM164_S02g002255</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM234 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QD37"/>
    <dbReference type="OMA" id="VIAKETW"/>
    <dbReference type="OrthoDB" id="43458at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018908">
        <property type="entry name" value="TMEM234"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28668">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 234"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28668:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 234"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10639">
        <property type="entry name" value="TMEM234"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="201"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="47"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="47"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="122"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM32104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="252" mass="27626" checksum="BBE5084A5BB657E5" modified="2014-04-16" version="1">MDPDPGIPIEPAPSVFNYVLSFLLVGVAWGFTTPFIRRAAADFNARQAKQANDPNTSARRRRRSQDSARAGFTDAGEAQELLSREEEDSDSGADVPRRSTSSDVNRKPKTAGQDTGLAEQSGSRDREDREGGADEDEDDVPMPAWRHGGPVKQSWLRAKIVSVFWTVVNLLRTPAYAIPLVINLTGSIWFFLLVGKHELSLTVPLANSSAFLFTVLGEWYVDRKVIAKETWLGMGLVLGGIALCVHSKNQAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W6QD93</accession>
    <name>W6QD93_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S02g002310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QD93"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM32159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="82" mass="8903" checksum="16877D9C1E1FCABA" modified="2014-04-16" version="1">MQGNNSPNLASKHTAPSSRTSRTDIITPTVTLRRKKKVEDRRITLWQGRANPTGGLNPRPPPTPGVVKSADSLNPPATLDQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W6QDH7</accession>
    <name>W6QDH7_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Tyrosine-protein kinase, catalytic domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PROQFM164_S03g000845</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QDH7"/>
    <dbReference type="STRING" id="1365484.W6QDH7"/>
    <dbReference type="OMA" id="GMAEWMT"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000985">
        <property type="entry name" value="Serine/threonine-protein kinase MARK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000567">
        <property type="entry name" value="Serine/threonine-protein kinase MARK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="335"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="29"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="254"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="506"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="118"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="145"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="156"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="173"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="216"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="254"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="275"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="371"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDM34121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="658" mass="72579" checksum="1A743823F6EBF5BB" modified="2014-04-16" version="1">MAHSERAGLASGLAGLRIETKFHERNKSKWTNENSVRRATTVGDGIESDHTNQSHDYARRHDTDQDHSLLSDLHSATPPISVPRHDAQHHAVDADSFPHKPDSVQGSPLDSYLHTRRPSISFNPKVSVDSGNQIPLEEPLSMGDVKNRPPQKFESRSSGLRNALSQDDEHVEASQSPNWSPKQSLDRSSPTGESRTQPFAISENGSNAGSELVRPTSLTSQSTVSPVTDEVRTPPDYSSHTLLSPFCVPSPTQFFASPEDNGSSWSGGIPTSFGSKRSSTLDRSSSLRNSTRHSSRRSTNSGGKSPASMFLSMWNNVEEPAPQPDDEGQMVGDDYVLGKQIGFGGFSAVKEAYKAEKNGETKRLAVKIVKKQITGRSEHENDQVQAEFDHEVRVWRYLNHPHILTLDAVYETDHATFCFTKLAIGGTLFDLVRQNRSGLDTQLAKKYAYQLACAIRYLHEDARVVHRDIKLENCLLDPVESADDTTSSNLVLCDFGMAEWMSIDNGGDSPDPYEDAADRPPPQQMGPAGSSTSVAGSLEYASPELLQSVGGVVHPSVDMWAFGVIVYTVIVGSRPFQDSFTPRVQANIISGNWDHNAVYGDTVDGPLRQDRQYALELVRGCLEMDPNKRWTIRHVLASSWLREVHEAAEPSPDTVWRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W6QDM2</accession>
    <name>W6QDM2_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chromatin SPT2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S01g001518</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SPT2 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QDM2"/>
    <dbReference type="STRING" id="1365484.W6QDM2"/>
    <dbReference type="OMA" id="QHKKVEK"/>
    <dbReference type="OrthoDB" id="5430658at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013256">
        <property type="entry name" value="Chromatin_SPT2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08243">
        <property type="entry name" value="SPT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00784">
        <property type="entry name" value="SPT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="339"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="65"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="96"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="188"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="295"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM27707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="358" mass="38671" checksum="4B6E574A97BC3D09" modified="2014-04-16" version="1">MSFLDSILSSIQTGKPSQLPVTQVPTSPTPTSPAPASIPKKEDRKPTAVRRPPSTSGNVSGGIKRKADEQLPRPPKPENKVANSSAAMRPTLPTRPAVSSVPPRVVSKPNLPTTSRPTMPKPTPKPSLSATPKVIPPRKEPDPKPASAGAATTSKPPPKGSFAEIMAQAKAKQETAPVGVGLLRHQPGSKERLTKVERKRRMMELQAKEKEARLGRKAGSGVSAKGKPAVRQRDSEGPSYKGTAKPTQTPEPLTYRGTAGLPSNRGGNDRRHQSRNRQNEYLGTDEEDEGDLGGYDDYYSDASSDMEAGMDDVDREEAAALAFAKQEDEKELRQEMAAKKEKLERQRKLAALASRSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W6QFF8</accession>
    <name>W6QFF8_PENRF</name>
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        <submittedName>
            <fullName evidence="3">Genomic scaffold, ProqFM164S04</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QFF8"/>
    <dbReference type="STRING" id="1365484.W6QFF8"/>
    <dbReference type="OMA" id="KWIFAIT"/>
    <dbReference type="OrthoDB" id="2128042at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015079">
        <property type="term" value="F:potassium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031606">
        <property type="entry name" value="Kch1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36424:SF1">
        <property type="entry name" value="LOW AFFINITY K(+) TRANSPORTER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36424">
        <property type="entry name" value="PHEROMONE-REGULATED MEMBRANE PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16944">
        <property type="entry name" value="KCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="225"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="304"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="328"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="344"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="372"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="401"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="443"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="469"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="525"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="562"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="583"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="600"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="621"/>
            <end position="630"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM35230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="667" mass="73056" checksum="FEE08938E723DDCE" modified="2014-04-16" version="1">MLCGGDREKGDVAMEEKWDYVNLDDFKSESCWTPFSYFFIWLSLFISIAVYGVDTFTAVNLLAFSRWSGRVQPAIPFNISRWIFAACIIASFILLAYRWIHAIRSIRSGSITRSFLDPLAVRIQSIRLGKRGRGYRRFLVFAELTKDRKAAEYVALYAYFSFQFWMNTIFADGPRQVLNAITLYSVMQMDLIPGGKNAAHDDGTSSVGQFFNNVKILAEDNNLQAVVLFGMLFTLVVWVLSVLKLISAIVLYLIFLFHHIPAEDGSLSKYCRRKVGQRLKRIVHRKNTKALAKGLKLQNRAPTQPMLAMDSNPTLPSLAEDKHPTVASSLSRSTTQTTLPPYSRSASIAPTANPTLPNLELDAKPTLTRTGTSSSAMSESASLTSNAAGMGYSPLDGRRPTLPPVPPLPSNVPSRMATPHSRGTPAPYENDGCNSPGPEYRNLTDSSDSRSYQSHTPAPDYASAEMDPSDYHDYFNRDDAPAHYDPYGPPRGTSREADGYGGRYGTPSDQRGAPRAQQDYYPQDPYSNRSYTPASTGGTPAPYRSYTPASTGGTPAPYRSYTPASTGGTPAPYRSNTPASHRPTPPPQAALAQPPPRTFTPVSSATPAPQNGGYAAFNPSMVHQTSQPRSNGPPGPGSFTRANTASPSAMHRAPPGHTFTRSNTHQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W6QFL5</accession>
    <name>W6QFL5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g002233</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QFL5"/>
    <dbReference type="STRING" id="1365484.W6QFL5"/>
    <dbReference type="OMA" id="CICDDEP"/>
    <dbReference type="OrthoDB" id="4487429at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004879790" evidence="1">
        <location>
            <begin position="18"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM28422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="221" mass="25186" checksum="8D7F591998C8BC75" modified="2014-04-16" version="1">MLNWWAVIPLLISVTAGWLGYQIKPEGSAPQIPLTMPQDALQELLQEVSSEWTTPQDRFLGEPQFWIYYSSGPGVTVKGWPSQGGIYTLDVSSRVEIEFLELDPFNNTRRPTNSDPNWQQKENAHCDRMRYLSPTWWPTELAWLESGMSGMLDERSNNYVRVGWTSDGGAWVWKTTKEGASKKGGAMLQNARTMEERCLVIERLGGTFYANPKYCPFLDLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W6QFY6</accession>
    <name>W6QFY6_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g002373</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OMA" id="IFEDWKG"/>
    <dbReference type="OrthoDB" id="3945172at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM28562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="138" mass="15570" checksum="ED35111FA17724E6" modified="2014-04-16" version="1">MRNHCIFSATSMLHNMSVSRQPWRVILPLQSVIRPPVLRAPLGVRYYSIFEDWKGSSAEDHIRKRSQKGDTDDVHSEAAASGLEERRAYQGIADDSKSQGMTERGGTKHGKKAKEEHPNAPEPIIGMNDERQKVSPYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W6QG56</accession>
    <name>W6QG56_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Succinate--CoA ligase [ADP-forming] subunit alpha, mitochondrial</fullName>
            <ecNumber evidence="6">6.2.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Succinyl-CoA synthetase subunit alpha</fullName>
            <shortName evidence="6">SCS-alpha</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PROQFM164_S04g000654</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>succinate + ATP + CoA = succinyl-CoA + ADP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17661"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.2.1.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Heterodimer of an alpha and a beta subunit. Different beta subunits determine nucleotide specificity. Together with the ATP-specific beta subunit SUCLA2, forms an ADP-forming succinyl-CoA synthetase (A-SCS). Together with the GTP-specific beta subunit SUCLG2 forms a GDP-forming succinyl-CoA synthetase (G-SCS).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 8">Belongs to the succinate/malate CoA ligase alpha subunit family.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.5" evidence="6"/>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QG56"/>
    <dbReference type="STRING" id="1365484.W6QG56"/>
    <dbReference type="OMA" id="VIICITE"/>
    <dbReference type="OrthoDB" id="1664372at2759"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00999"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009361">
        <property type="term" value="C:succinate-CoA ligase complex (ADP-forming)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004775">
        <property type="term" value="F:succinate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004776">
        <property type="term" value="F:succinate-CoA ligase (GDP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000002">
        <property type="entry name" value="Succinate--CoA ligase [ADP-forming] subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.261:FF:000005">
        <property type="entry name" value="Succinate--CoA ligase [ADP-forming] subunit alpha, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01988">
        <property type="entry name" value="Succ_CoA_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017440">
        <property type="entry name" value="Cit_synth/succinyl-CoA_lig_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033847">
        <property type="entry name" value="Citrt_syn/SCS-alpha_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005810">
        <property type="entry name" value="CoA_lig_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="SUCC_ACL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004230">
        <property type="entry name" value="PRK05678.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01019">
        <property type="entry name" value="sucCoAalpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11117:SF2">
        <property type="entry name" value="SUCCINATE--COA LIGASE [ADP_GDP-FORMING] SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11117">
        <property type="entry name" value="SUCCINYL-COA LIGASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02629">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001553">
        <property type="entry name" value="SucCS_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01798">
        <property type="entry name" value="SCOASYNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01216">
        <property type="entry name" value="SUCCINYL_COA_LIG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00399">
        <property type="entry name" value="SUCCINYL_COA_LIG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="CoA-binding" evidence="9">
        <location>
            <begin position="36"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="6 7">
        <location>
            <position position="282"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="49"/>
            <end position="52"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="128"/>
            <end position="130"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared with subunit beta</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00061754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001553-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDM35773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="329" mass="34412" checksum="5E8D7C7703BAA35E" modified="2014-04-16" version="1">MQAFRRNTLSALRNVGATQRRTQATSAYSETLNNLKINKDTRVLFQGFTGKQGTFHAEQAIAYGTNVVGGTNPKKAGSMHLDRPVFANVSDAMKETGATASAIFVPPSLAAAGIEEAIAAEMGLVVCITEGIPQHDMVRITDILKTQNKTRLIGPNCPGIIAPGQCKIGIMPGFIHKRGRVGIVSRSGTLTYEAVNQTTLAGLGQSLVVGIGGDPFSGTNFIDCLKVFLEDPETDGIIMIGEIGGSAEEDAAEWFKANNIHNKPAVSFIAGISAPPGRRMGHAGAIVSGGKGGADSKIAALTDAGVIVERSPASLGKTLLAEFVKRDLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W6QH25</accession>
    <name>W6QH25_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Geranylgeranyl transferase type-2 subunit beta</fullName>
            <ecNumber evidence="8">2.5.1.60</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">BET2</name>
        <name evidence="10" type="ORF">PROQFM164_S01g002728</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>geranylgeranyl diphosphate + L-cysteinyl-[protein] = S-geranylgeranyl-L-cysteinyl-[protein] + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21240"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11537"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57533"/>
            <dbReference type="ChEBI" id="CHEBI:86021"/>
            <dbReference type="EC" id="2.5.1.60"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the protein prenyltransferase subunit beta family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.60" evidence="8"/>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QH25"/>
    <dbReference type="STRING" id="1365484.W6QH25"/>
    <dbReference type="OMA" id="VKRCQCP"/>
    <dbReference type="OrthoDB" id="5428259at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005968">
        <property type="term" value="C:Rab-protein geranylgeranyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004663">
        <property type="term" value="F:Rab geranylgeranyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02894">
        <property type="entry name" value="GGTase-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.20:FF:000009">
        <property type="entry name" value="Geranylgeranyl transferase type-2 subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045089">
        <property type="entry name" value="PGGT1B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001330">
        <property type="entry name" value="Prenyltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026873">
        <property type="entry name" value="Ptb1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774:SF11">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE-2 SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00432">
        <property type="entry name" value="Prenyltrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 8" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Prenyltransferase alpha-alpha toroid" evidence="9">
        <location>
            <begin position="19"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDM28917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="333" mass="36189" checksum="19D151CD6AD4EF0C" modified="2014-04-16" version="1">MALVSGPGRAGVSPADSELHTSKHVTYIKNLDTRKDELEYWLTEHLRLNGVYWGLTALHILGHPDTLPRDETIDFVLSCQNENGGFGAAPGHDAHMLYTVSAVQILVTIDAVDELEKRGRGGKEKVGSFIANLQNADGSFMGDQWGETDTRFLYGALNALSLLRLMDLVDVPKAVAHIQSCENLDGAYGIRPGAESHAGQVFTCIGALAIAGRLDLVNKDRLGAWLSERQIESGGFNGRPEKLADACYSWWVGSSLAMIDRLHWIDGDKLAAFVLQCQDPDAGGFADRPGNMVDVYHTHFSLAGLSLLKFDGLEEIDAVYCMPKSITTKCLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W6QH55</accession>
    <name>W6QH55_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein yippee-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PROQFM164_S03g000258</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the yippee family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QH55"/>
    <dbReference type="STRING" id="1365484.W6QH55"/>
    <dbReference type="OMA" id="SSRIYGC"/>
    <dbReference type="OrthoDB" id="6407410at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034751">
        <property type="entry name" value="Yippee"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004910">
        <property type="entry name" value="Yippee/Mis18/Cereblon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039058">
        <property type="entry name" value="Yippee_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13848">
        <property type="entry name" value="PROTEIN YIPPEE-LIKE CG15309-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03226">
        <property type="entry name" value="Yippee-Mis18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51792">
        <property type="entry name" value="YIPPEE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Yippee" evidence="5">
        <location>
            <begin position="13"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU110713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDM33534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="110" mass="12701" checksum="362028EACD60345B" modified="2014-04-16" version="1">MGLSYNVYLTANKIFGCKGCKTHLADFNDIMSRNFRGQHGKAYLFNKVVNVTQGEPVERNMTTGRHLVRDIACRQCKETVGWKYDKAYESSEKYKEGKFILEEELFCVVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W6QI11</accession>
    <name>W6QI11_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">NAD(P)H-hydrate epimerase</fullName>
            <ecNumber evidence="3 10">5.1.99.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">NAD(P)HX epimerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">mug182</name>
        <name evidence="12" type="ORF">PROQFM164_S04g000946</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>(6R)-NADHX = (6S)-NADHX</text>
            <dbReference type="Rhea" id="RHEA:32215"/>
            <dbReference type="ChEBI" id="CHEBI:64074"/>
            <dbReference type="ChEBI" id="CHEBI:64075"/>
            <dbReference type="EC" id="5.1.99.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 10">
            <text>(6R)-NADPHX = (6S)-NADPHX</text>
            <dbReference type="Rhea" id="RHEA:32227"/>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
            <dbReference type="ChEBI" id="CHEBI:64077"/>
            <dbReference type="EC" id="5.1.99.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="10">Binds 1 potassium ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the NnrE/AIBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="5.1.99.6" evidence="3 10"/>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM36065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QI11"/>
    <dbReference type="STRING" id="1365484.W6QI11"/>
    <dbReference type="OMA" id="RHLFHYG"/>
    <dbReference type="OrthoDB" id="10064708at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052856">
        <property type="term" value="F:NAD(P)HX epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10260:FF:000005">
        <property type="entry name" value="NAD(P)H-hydrate epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10260">
        <property type="entry name" value="YjeF N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01966">
        <property type="entry name" value="NADHX_epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004443">
        <property type="entry name" value="YjeF_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036652">
        <property type="entry name" value="YjeF_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032976">
        <property type="entry name" value="YJEFN_prot_NAXE-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00197">
        <property type="entry name" value="yjeF_nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13232">
        <property type="entry name" value="NAD(P)H-HYDRATE EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13232:SF10">
        <property type="entry name" value="NAD(P)H-HYDRATE EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03853">
        <property type="entry name" value="YjeF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64153">
        <property type="entry name" value="YjeF N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51385">
        <property type="entry name" value="YJEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8 10" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 10" id="KW-0630">Potassium</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YjeF N-terminal" evidence="11">
        <location>
            <begin position="34"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="84"/>
            <end position="88"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="150"/>
            <end position="156"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDM36065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="260" mass="28325" checksum="D8ECD5CB12BCB526" modified="2014-04-16" version="1">MIRSTFARIRLPPSIRRYSKPAIMSLKAISAKDAASLDKDLMEVGGWSLDQLMELAGLSVAEAVWRVHPPSAGKKVLVVCGPGNNGGDGLVATRHLAQFGYTPSLYYPKQGKKELYERLKTQLHNLSVPFVDDFEAALKTADFLVDAIFGFSFGGPLRDPFDKIVSQIESANVPVLSVDAPSSWDIQTGPPKEGPGAKFMPHALISLSAPKPCVAFYHGRHFIGGRFLTKNITDKYGLDLPKYQGVDQVLEIGVDAEGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W6QI35</accession>
    <name>W6QI35_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase-like domain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S05g000306</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QI35"/>
    <dbReference type="STRING" id="1365484.W6QI35"/>
    <dbReference type="OMA" id="RIMLKQY"/>
    <dbReference type="OrthoDB" id="4177740at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM36473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="262" mass="30022" checksum="35A03FFB24C10805" modified="2014-04-16" version="1">MTSVETRDHQLDRWLLMKIEHAIENLEEHKLNNTELKKWNIRFSSMTLDQNSDLKPRFFAPKPNLPLPNDEILDEAAEPDSGDDDYYAAAYGMNTFLDSYAFSQVGLWNDGPWRSMDCGRYSTYKSLWFYGTPSLGPSPAFGALTMIDSSGKEYPHFKAVIYTDMEADDKTCFRSEVLISLRLMLAQLRKVRLMHHKIAPVLLISLTGKYVRVLESYFDGELLQIRSTCLYKFSDRDSISTLYMMLAGYMLGPPIGDTSSFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W6QI85</accession>
    <name>W6QI85_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">alpha-1,3-glucan synthase</fullName>
            <ecNumber evidence="2">2.4.1.183</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PROQFM164_S04g000607</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>[(1-&gt;3)-alpha-D-glucosyl](n) + UDP-alpha-D-glucose = [(1-&gt;3)-alpha-D-glucosyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19749"/>
            <dbReference type="Rhea" id="RHEA-COMP:11150"/>
            <dbReference type="Rhea" id="RHEA-COMP:11151"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28100"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.4.1.183"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase group 1 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.183" evidence="2"/>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1365484.W6QI85"/>
    <dbReference type="OMA" id="FLWYWGS"/>
    <dbReference type="OrthoDB" id="512920at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047657">
        <property type="term" value="F:alpha-1,3-glucan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070600">
        <property type="term" value="P:fungal-type cell wall (1-&gt;3)-alpha-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11323">
        <property type="entry name" value="AmyAc_AGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03791">
        <property type="entry name" value="GT5_Glycogen_synthase_DULL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000058">
        <property type="entry name" value="Alpha-1,3-glucan synthase Ags1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000052">
        <property type="entry name" value="Alpha-1,3-glucan synthase Ags2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058659">
        <property type="entry name" value="Mok11-13/Ags1-like_CBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058656">
        <property type="entry name" value="Mok11-13/Ags1-like_GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058657">
        <property type="entry name" value="Mok11-13/Ags1-like_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058658">
        <property type="entry name" value="Mok11-13/Ags1-like_Ig_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058655">
        <property type="entry name" value="Mok11-14/Ags1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058654">
        <property type="entry name" value="Mok11-14/Ags1-like_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013534">
        <property type="entry name" value="Starch_synth_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47182:SF2">
        <property type="entry name" value="CELL WALL ALPHA-1,3-GLUCAN SYNTHASE AGS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47182">
        <property type="entry name" value="CELL WALL ALPHA-1,3-GLUCAN SYNTHASE AGS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26127">
        <property type="entry name" value="12TM_Mok13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26122">
        <property type="entry name" value="CBM_Mok13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26108">
        <property type="entry name" value="GH_Mok13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13692">
        <property type="entry name" value="Glyco_trans_1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08323">
        <property type="entry name" value="Glyco_transf_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26114">
        <property type="entry name" value="Ig_2_Mok13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26111">
        <property type="entry name" value="Ig_Mok13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1080"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1957"/>
            <end position="1979"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1991"/>
            <end position="2008"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2015"/>
            <end position="2034"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2046"/>
            <end position="2069"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2081"/>
            <end position="2102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2126"/>
            <end position="2147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2168"/>
            <end position="2187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2207"/>
            <end position="2228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2235"/>
            <end position="2252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2281"/>
            <end position="2302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2309"/>
            <end position="2331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2355"/>
            <end position="2375"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="9">
        <location>
            <begin position="69"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1651"/>
            <end position="1760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1651"/>
            <end position="1660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1727"/>
            <end position="1736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1750"/>
            <end position="1760"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDM35726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="2383" mass="266877" checksum="C34A15D75CC2456E" modified="2014-04-16" version="1">MELLTSITQYLAIVAIYIRIVQSLPYLPEEADWNLNQNQTATHPLDYSGRWDDHTYNPSPENWRFPFYTIFLDRFVNGDPSNDNANGTQWEHILTSNEFRHGGDVLGLVDTFDYLQGMGIKGVYLAGTPYINFPWAADGYSPLDLTLLDHHFGTIEDWRTMISEAHRRGIYVLFDNTFATMGDLIGFQGFLNKSAPINPNEYDSVWKYDRRYWDFQPGNEVESECPWEYPRFWNDDGTGLTTTTLGPSCRDSEFDQYGEVAAFGNYTEWEGQISKFAFVQDRLRGWRPDVLAKIKHFSCLTITMLDIDGFRVDKALQVTLDSLGEWSEYMRDCAKQVGKDNFYIPGEIVGGNSYGSLYIGRGHQTNQTISNLTEAFMMTNKTNKSDEDLFLRPAERSALDGAAFHYTLYRGLSRFLGLDGTFTAEGDPPVNFVDTWNGLVETNDMVNTNTGKFDPRHLFGVTNQDVFRWPGIKNGTHKQNLGLYIASLLMPGIPILSWGEEQDFYVLENQADNYVFGRGPMSSAQAWQLHGCYKLGSSKYVDFPLDRSLTGCKDDSVSLDHRDPSHPVRGLIKMMFEMRQNYPTLNDGWYLQQLSNQTFDIYLPGSGGTPTETGMWSVMRSRFADAQNFDGQGQGNQSVWLVYSNDNKTVEHKFNCSSKDALISPFPAGTRVKNLFPPFEELTLANSSTRLGFEGSKVPNGCYPNLTMPAWGFKAFVPKDNFVQPSPYVTRFSPGHDARLVPQGKSGDTVRIGFEFSQEMDCVDITNSLTITSKALNDESPQLDTTSVSCKPITETDVVTWPGALTSVFSYEVDLGNVFPGVHRVTLTNVTTADGNQSTGSVDHFLFRIGEINNPMVWPQLANYSRTLLFDNPSSETEPLSVMPQAPGADMWRYSLDFGATFSNWMTYTGFNTSIPGKNWSGTAKQAWEGEHILAQYWSKLTGSSAHWQHGDTQWAYKPPRRFPNLFIEGEFNQFGYDAGYSNKMALSNVSGQWEIHFMAEWPVQVAFNAWGLNEDGLPDQTQVFGDIDGDNVLDQVPPVTLLSNVFNVTIPPPSPYLSFKLSVGDGDLRVYATPTGSRWVQLAIFIVLAIVPVATALGAVFVYLKAFYQVKFNQVGVTEKRSSFAPLVSPLVSVFQKVAHRSTNPGLALTNVGPFPSENGGVVGATVNTCRRTVLIATMEYDIEDWGIKIKIGGLGVMAQLMGKHLAHQDLIWVVPCVGGVDYPRDDPREPMVITVLGNNYQVDVQYHQLQNITYVLLDAPVFRAQSKSEPYPARMDDLDSAIFYSAWNQCIAEAIKRFPAIDLYHINDYHGAAAPLYLLPHTIPCCLSLHNAEFQGLWPMQTPQQNQEVCSVYNLDHALVKKYVQFGEVFNLLHGASNYLKIHQNGFGAVGVSKKYGKRSYARYPIFWGLKNIGALPNPDPSDIAEWDQNANNNPEDVIIDAEFEASRAALKKQAQEWAGLKVDPEAELFVFVGRWSMQKGVDLIADIFPSILDAHPKVQLMCIGPVIDLYGRFAALKLNRLIDLYPGRVFSRPEFTALPPFIFSGAEFALIPSRDEPFGLVAVEFGRKGALGVGSRVGGLGQMPGWWFTIESMTTKHLIQQFKMAINDALKSSQETRALMRARSGKQRFPVAQWVEDLETLQTTSIKKHAKYSKRHDRGSWRFSRGSTLVPESIPKVSPSSDNSREQSRSRGSTVSVPPSRPITTEMRLSGPRPGLDYVPSPTTPSFSLNMSDNEPDSDADPRRRPLSSNHLTDSRVVYTSVSDGEDLEPISGDGNDRLSPFRTPTVYFARSGASTPALSAGSEDGVLGRRDARASMMSLVSVDDITKEKQHYNLQKVDPFFTDVNNEYAEKFEKKLAGLNGKNSEDQLCIEEFLEKSEKDWFNRYRDVKLGKSPLPSPAPSVFRFKVHEIGRSETPPINGPGARPNTGQFLLPNDYVPPTGVKRFMLMKLGDWPVYSIFLAIGQILALNSYQITLLNGEIGETAEKLYILASIYLASSIIWWMVFRLVPSVYVLTIPFLIYGLAFLFVGLTGHIQNGTSQTWLQNVGVGLYSFASSSGSIFFALNFGDEGGAPLRSWIYRATVIQGTQQLFISFLWYWGSWMATLNQKGSEQFSLAMTDPGALLGIGLGLACFMWLLGALIFFGLPTYYRQAPGQVPTFYLSLFRRRIILWFFYMVFISNYWLSAPYGRNWLYLWSSKHAQVWHIVLLVLLFFIFVWAAALWVFHVFSKRHAWFIPIFAVGLGAPRWAQILWATSNIATYIPWAGGPVAGAILGRALWLWLGVLDSLQGVGFGMILLVTMTRFHVTFTLLAAQVVGSVATILARATAPDKLGPGDVFPDFSAGVAAGLEKADFWVCLLFMLSINVLCIFFYRKEQLAKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W6QII4</accession>
    <name>W6QII4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g003204</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QII4"/>
    <dbReference type="OrthoDB" id="4368016at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM29392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="112" mass="12610" checksum="9BEB0471D5FD5803" modified="2014-04-16" version="1">MTVSDNLDCNQLGRFLSAVLGATVTLILAKIVEKCYYYFQWRYRSANTTIFNARTAAGEDIRALDNPDDTLYLPDYNTPVILPGHAISNMDRDIKKEDLHNLGATRPWNGSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W6QIP1</accession>
    <name>W6QIP1_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S05g000093</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QIP1"/>
    <dbReference type="STRING" id="1365484.W6QIP1"/>
    <dbReference type="OMA" id="CPMVTII"/>
    <dbReference type="OrthoDB" id="5098281at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM36260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="297" mass="33736" checksum="94569645F0E462DD" modified="2014-04-16" version="1">MPSNSTFPAIIHIRDFVEHVEPDPTRPGKGLSMQLRVSLNLPWKDIQSDDVKQDKILTLVRFFNEGNQSDLYKPNTFVYSSGSFLTTSSDDEEFHISSTPTIWTARWPTNGGPTLLHYRLQTTVYNSSTRTNHTFPITAYFKNGQRWANFPPLSMNTHVFLTGRVFGLTKEHRQLAIVTDDIHFLPTQNHQLPATPPATGKRKRVDRWSQRAGPQTPTKSAARPQTESLPITYQSQDPTQIIAPGDDDEEDAQITWPDTPEEIKASSRTTTPVPERRSQRPRKTSYADILAQSKYDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W6QJ39</accession>
    <name>W6QJ39_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">tRNA (guanine(10)-N(2))-methyltransferase</fullName>
            <ecNumber evidence="9">2.1.1.214</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">TRM11</name>
        <name evidence="13" type="ORF">PROQFM164_S05g000636</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM11 methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.214" evidence="9"/>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QJ39"/>
    <dbReference type="STRING" id="1365484.W6QJ39"/>
    <dbReference type="OMA" id="AFNKWSR"/>
    <dbReference type="OrthoDB" id="296065at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043527">
        <property type="term" value="C:tRNA methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160102">
        <property type="term" value="F:tRNA (guanine(10)-N2)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000241">
        <property type="entry name" value="RlmKL-like_Mtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016691">
        <property type="entry name" value="TRMT11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059073">
        <property type="entry name" value="TRMT11_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13370">
        <property type="entry name" value="RNA METHYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13370:SF3">
        <property type="entry name" value="TRNA (GUANINE(10)-N2)-METHYLTRANSFERASE HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25904">
        <property type="entry name" value="Tmrp11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01170">
        <property type="entry name" value="UPF0020"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017259">
        <property type="entry name" value="tRNA_mtfrase_TRM11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51627">
        <property type="entry name" value="SAM_MT_TRM11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 10 13" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 10 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 10" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="3 10" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="tRNA (guanine(10)-N(2))-methyltransferase TRMT11 N-terminal" evidence="12">
        <location>
            <begin position="1"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal RNA large subunit methyltransferase K/L-like methyltransferase" evidence="11">
        <location>
            <begin position="186"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00066937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF25904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDM36803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="454" mass="51612" checksum="F31EBF154A404F92" modified="2014-04-16" version="1">MDYLVRFAQLHETFRRPELQACATLAGADIEFITYNEYSPYCVVRLPDEAAARAVAKRSILVKDIFELWGEGTNYEELHADVRRRTQHRWNDYIAVPFKFTIDYFAGTRSLVQKGEIIRSFSYMGFKGPIRLKDPDEEFFVMEEYIDDVEVSKLGVSRTEDPRKIYLSRKIADSCREDVLKYDLKKRRYISTTSMDAELSLITANMALAAPGKLFFDPFVGTGSFIVAASHFGALTLGADIDGRSFRGKEKGKLGVYENFDQYGIKSKFIDTFTSDLTNTPLTRTAVLDGIVCDPPYGVREGLRVLGNRKGKPAVNVIIDGIPAYLRPGFIAPKRPYGFEALQNDVLNFAVRSLVPNGRLSMWMPTTNDEKTEFPVPMHQNLEIVSISVQSFNTWARRLITYRRLPEGELSDVTLARKKIDDEGTTADDLNAFRRVHMLRGHGTRVDQDQKKTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W6QJF4</accession>
    <name>W6QJF4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g003524</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QJF4"/>
    <dbReference type="OrthoDB" id="5291055at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM29712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="64" mass="7631" checksum="65E1500AC5C9779A" modified="2014-04-16" version="1">MALKAGSKLNKLNRKKEEDKRKNIAMEFPATITPYRLNKLNRKKEEDKRKNIAMVKILQEPFWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W6QK51</accession>
    <name>W6QK51_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Threonine/serine exporter-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PROQFM164_S05g000209</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ThrE exporter (TC 2.A.79) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QK51"/>
    <dbReference type="OMA" id="WHGNAVS"/>
    <dbReference type="OrthoDB" id="413008at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010619">
        <property type="entry name" value="ThrE-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051361">
        <property type="entry name" value="ThrE/Ser_Exporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024528">
        <property type="entry name" value="ThrE_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31082:SF11">
        <property type="entry name" value="DUF1212 DOMAIN MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G07620)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31082">
        <property type="entry name" value="PHEROMONE-REGULATED MEMBRANE PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06738">
        <property type="entry name" value="ThrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12821">
        <property type="entry name" value="ThrE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="399"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="424"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="451"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="482"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="516"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="561"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="609"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="640"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="685"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="domain" description="Threonine/serine exporter-like N-terminal" evidence="8">
        <location>
            <begin position="292"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="domain" description="Threonine/Serine exporter ThrE" evidence="9">
        <location>
            <begin position="567"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="129"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="188"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="251"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="21"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="39"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="146"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF06738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDM36376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="721" mass="78592" checksum="862FE302DDDD7D78" modified="2014-04-16" version="1">MSDAQEKAPPIPPHPSAGTAEADRAEGSDHNVDSNAETLRPDEAHPEPETLYQRCRAAGRRIRNRAVIIAEMLGRPHEKGDGLNSPMLPDYYETLDDIRAYEARQALDEEARLPGTDYDSQARLLMEQMGSQSRLRRPHHIKEPCSGSTTPGTPGTPDESAGPGSPPGGLLSHLLRVYADNLHAARLSSMSTASEPSPDAEPKPDAEPIALPDTTTGEKKDKSKWYNHPNKPSHNYASSLVNASMDLCRVALPGATGPPPATPNERKKENRKGKKNIKLTVHIAAILARQQYIMQLCRALMRYGAPTHRLEEYMMMTSNVLDIKAQFMYIPGCMFMSFDDQVTRTTEVKIVRVVQGLDLSRLAEVHNVYKHVVHDIISVEKAIHELDQIMQRKPRYNRWLLILLTGLASVTVGPYSFSARPIDLPIIFMLGCLVGFMQYVVAPISATYSNVLEVTVAILVSFISRAFGSIQHNGERVFCFSAMVQSSIAMILPGFAVLSSSLELQSHQMNAGSIRLVFTIIYSLFLGYGVTVGTTIYGLMDKNATNEATCSHLPEVWGNEYIQHFPFVALFCLFAGLINQSKPRQLPVTIFMGMCGYIANYFSTKKLGANQVANTVGAFTIGLLANLYSRVWHGHAAAAIIPGIFTLVPSGLASSGSIISGLQYAEAVAAGDATNSAASNSSLTALGYGMIQTAIGISVGLFISDLIVYPHGKKRSGIFSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>W6QK64</accession>
    <name>W6QK64_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="10">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PROQFM164_S05g000608</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QK64"/>
    <dbReference type="OMA" id="FIAMEIT"/>
    <dbReference type="OrthoDB" id="6339427at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015798">
        <property type="term" value="P:myo-inositol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015791">
        <property type="term" value="P:polyol transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050814">
        <property type="entry name" value="Myo-inositol_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020:SF9">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020">
        <property type="entry name" value="PROTON MYO-INOSITOL COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004882111" evidence="8">
        <location>
            <begin position="24"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="54"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="146"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="175"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="267"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="306"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="338"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="11"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDM36775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="378" mass="41464" checksum="CF3402F443285BE4" modified="2014-04-16" version="1">MKSPRMLVLTLGVFAAFSGMLSGLDQSVISGALPGIRKHFIASGDWTSLEDPKLATDISLISSLMPLGAMAGAVMMTPLNYYFGRRNSIIISCLWYTLGGGLCAGCRSVGMLFAGRFILGIGIGIEGGCVGIYISECVPPEVRGNLVSVYQLMIAFGEIIGYAAGGVFFDVRSGSWRWMLGSSLLFSTILLVGMCFLPESPRWLVSKNKTGRAWQVWKSLHDMADPKSLDEFIAMEITVKHDVDATTSEAWYNRYMQVCTQPRNRRALVYATAMIFFGQMTGINAVMYNMSNLMAKMNFSDRESVLMSMVGGGALFFGTVPAVFTMDRFGRRVWAQNILMFIVGLVLVGVGYLYTNNGVDYFNEHRATALGLFFSGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W6QL79</accession>
    <name>W6QL79_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S03</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S03g001681</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QL79"/>
    <dbReference type="STRING" id="1365484.W6QL79"/>
    <dbReference type="OMA" id="THQYRIK"/>
    <dbReference type="OrthoDB" id="2104739at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13391">
        <property type="entry name" value="HNH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HNH nuclease" evidence="1">
        <location>
            <begin position="121"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM34954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="315" mass="35354" checksum="6AA7DBEA9CC3DC57" modified="2014-04-16" version="1">MTELNRKLNGYVPLKPTDRTKYFLRDFYKTLPPDGKENLAQDISGCENDETLRQLVQSIRTGLLVPLKAQGGKTPTEITPSPRSGIEDSIEDLKSQNIEPISRSYQSQLRNHCLERDGNKCLATGMYSQAHAYPPNVLTTSLEAAHIIPFAFGSFQANNSESVDRNTKIWVNLRRYFPALRNMSFTPEQINSEKNILMLDAEIHKEFGQFRIIFEATGVTHQYRIKTFSGISTRTLRDLPQSRLVYFTVHNGSWELPDPQILEMHACIGKFLHMSGQAEVIDKILEDFADCGGLAPSGSTNIADLLAVSCLAVLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W6QLM7</accession>
    <name>W6QLM7_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glutamine synthetase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">glnA2</name>
        <name evidence="9" type="ORF">PROQFM164_S06g000291</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the glutamine synthetase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792020">
        <property type="protein sequence ID" value="CDM37330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QLM7"/>
    <dbReference type="STRING" id="1365484.W6QLM7"/>
    <dbReference type="OMA" id="NIMTFRL"/>
    <dbReference type="OrthoDB" id="77835at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamine synthetase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006576">
        <property type="term" value="P:biogenic amine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006542">
        <property type="term" value="P:glutamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.70:FF:000013">
        <property type="entry name" value="Glutamine synthetase bacteria"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.590.10:FF:000005">
        <property type="entry name" value="Probable glutamine synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.70">
        <property type="entry name" value="Glutamine synthetase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.590.10">
        <property type="entry name" value="Glutamine synthetase/guanido kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036651">
        <property type="entry name" value="Gln_synt_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43785">
        <property type="entry name" value="GAMMA-GLUTAMYLPUTRESCINE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43785:SF12">
        <property type="entry name" value="TYPE-1 GLUTAMINE SYNTHETASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01230">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54368">
        <property type="entry name" value="Glutamine synthetase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="Glutamine synthetase/guanido kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51987">
        <property type="entry name" value="GS_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GS catalytic" evidence="8">
        <location>
            <begin position="123"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM37330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="487" mass="53817" checksum="D495E72978625E3B" modified="2014-04-16" version="1">MSSPADPEVTVENVAEILKNDTKVKVAGVDVDGILRGKLMKKDKFLSVITEGFGFCSVIFGWDQHDATYYKELAISNKQNGYRDLLAVPDLRSFRRIPWENNVPFFLISFLDPETREPVCACPRGLIKTAAAKAEAAGYRAMAGAEYEFYQFRTPGNHVTPEQGASATAAFLKSNPVDALPPVTEGMFGYSITRPLHNQDYYYGIFDACEKFRCDIEGWHTESGPGVYEAALQFGEAKDMADKAGLFKYVVKSFGIKHGITPCFMAKPRQGLPGNSGHMHISLVTADGKNAFIRDTPDPSPLYPDIAHLSDLGRHFLAGLLVGLPDIMPILAPTINSYKRLVENFWAPVTVSWGLEHRAASIRLITPPTASPKATRFEVRVPGADTNAHLVLAAILALGWRGVEKKLEIPLPPLARGEDMGGASDKGVRLAKSLKEAVVTFTRPESIAREVFGDLFVDHFAGTREHEVRLWEEAVTDWEMKRYIETV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W6QLN6</accession>
    <name>W6QLN6_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S04</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S04g000010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QLN6"/>
    <dbReference type="STRING" id="1365484.W6QLN6"/>
    <dbReference type="OrthoDB" id="2143914at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM35129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="114" mass="12774" checksum="1A6C2E42B2A53521" modified="2014-04-16" version="1">MTDIALAEPYRPLGYRHEMTSPLPSFDLSSALYGMTGVRPVNRNLAWSEVTRQFAQKFAGRSKGSIQVYWSTTLKKQRRSLADATFAVSDLAKRLTGQSRGKYSCWSQGQSAYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W6QM64</accession>
    <name>W6QM64_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycoside hydrolase/deacetylase, beta/alpha-barrel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S06g000036</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792020">
        <property type="protein sequence ID" value="CDM37076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QM64"/>
    <dbReference type="STRING" id="1365484.W6QM64"/>
    <dbReference type="OMA" id="ANWYMED"/>
    <dbReference type="OrthoDB" id="504708at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10938">
        <property type="entry name" value="CE4_HpPgdA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037950">
        <property type="entry name" value="PgdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47561:SF2">
        <property type="entry name" value="HYPOTHETICAL POLYSACCHARIDE DEACETYLASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47561">
        <property type="entry name" value="POLYSACCHARIDE DEACETYLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G05030)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NodB homology" evidence="1">
        <location>
            <begin position="30"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM37076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="310" mass="34618" checksum="016EF440582FB2D3" modified="2014-04-16" version="1">MTSRKPKVQILLSVDFDAVSGFLGTGASATTNLADYSSGFFAAQVGVPRLLRLFKKHGISSSVTWFVPGHSMESFPAETKAIVQSGAEIGCHGYAHEGSSQMTESQEREVIAKCVQLATDLTGKQPRGWRAPLYQLRTHTIQVLEEFGFLYDSSLTHHDSALYFVPRMSEPKAIDFSPSKSASTWMKPLPAPAARTPRSLVEIPCNWYMEDMTPMQFLPAAENSHGFVSPITIEQNWKSRFEFLYSEALEKSIEEDSEQGFVFPLVLHPDTSGMAHVVGMIDRMISWLKQREVEFVTFGECAAEWKKNHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W6QML6</accession>
    <name>W6QML6_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S09g000039</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792023">
        <property type="protein sequence ID" value="CDM38123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QML6"/>
    <dbReference type="STRING" id="1365484.W6QML6"/>
    <dbReference type="OMA" id="TIMQTEF"/>
    <dbReference type="OrthoDB" id="545169at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046366">
        <property type="entry name" value="MPAB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36124">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36124:SF1">
        <property type="entry name" value="ER-BOUND OXYGENASE MPAB_MPAB'_RUBBER OXYGENASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM38123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="427" mass="49398" checksum="4D6B3E47DD4DC99A" modified="2014-04-16" version="1">MASLPTSSTEDVPPSSSLLQASLSKQTLCMLLGLATYLALISSLRFQRRQTLHSKYSCYGTRQSMRSMSDQDAWVIQKTIMQTEFPFIVLKSLQFALFRTYGIPTISTLLLKTSQLSDSTISFKRYADTGTLIGEFMTFDPRSERARTAIARTKFLHKGYRASGKIMEADMLYTLSLFALEPIQFVKQFEWREMTEMERCAVGTFWKSLGDALEINYDALPSGKTGFQDGIHWLGEIGAWSQQYEIQHMKPHPRNKELAEKTIDVLVYNLPNFLKPLARYFVSYLMGDRLRTAMMMEEPPAFFSGILALIFKLRQLYLRYLSLPRPDFLRLNAFTDKPNKHGRNWVLIYDGAPFYVQPTIWNRWGPMAWFKWALGHPLPGDDGDKYYPQGYRTDDLGPKYFEGKGYRELEGFKETLRRQRMGQCPFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W6QMS4</accession>
    <name>W6QMS4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Zinc finger C2H2-type/integrase DNA-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PROQFM164_S02g001052</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QMS4"/>
    <dbReference type="STRING" id="1365484.W6QMS4"/>
    <dbReference type="OMA" id="WQYVREI"/>
    <dbReference type="OrthoDB" id="8117402at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001227">
        <property type="term" value="F:DNA-binding transcription repressor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001666">
        <property type="entry name" value="MDS1 and EVI1 complex locus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24399:SF70">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24399">
        <property type="entry name" value="ZINC FINGER AND BTB DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="208"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="236"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="264"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="345"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="563"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="14"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="68"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="109"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="154"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="345"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="386"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="404"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="443"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="465"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="476"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="506"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDM30902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="582" mass="62514" checksum="F1565B8690C3619A" modified="2014-04-16" version="1">MATLMSNNEPITVSNSLSANSITSSEPLSLFKSSKPESLSSIASAGLHVSRSRDQLPPMTSPISLPADRPEHEKDAERNSSQVAREALGASEKSPGAPNHEHSVHASPEQMQIDSHATEPSSDPYGSNDHHHNSLMHTSTVASPGPIEESASQDGDRRSRDNSEIDHDGKSFSYPMPTGNINDPRRGLSLPTAGYHRGSPRSPSAKKHRCPYCATEFTRQHNLKSHLLTHSQEKPFVCQTCQSRFRRLHDLKRHAKLHTGERPHICPKCGRRFARGDALARHNKGQGGCAGRRASMGSFAADDDYGDGTNGGTDDMDGLMYTAEPERMDEEDERRMTMPSIRKHEADTVARSDSIHSRQSNTYPPITAGRPSHLFPPPANHGGSGVSTSASQSTHMTFPPAGLTSGSSIFPTNSISDSPKPLSPNALSSQHDSAPPHRAHSPSMGQSLPHPQSSFGRANQSSNHAPPTLGLTLPQPGAPQLPPPPGMTSPDARFGMQAATKHTPSHSHSSTHSISHLKGFDGADANSSDASQIDKLWAYVRTMHDELTGLRTEVAALRAHVASSNSMPPAPVEVNLNNSGPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W6QNQ6</accession>
    <name>W6QNQ6_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S06g000568</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792020">
        <property type="protein sequence ID" value="CDM37606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QNQ6"/>
    <dbReference type="STRING" id="1365484.W6QNQ6"/>
    <dbReference type="OMA" id="VEYYECP"/>
    <dbReference type="OrthoDB" id="6105938at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM37606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="129" mass="15213" checksum="90DA284205636619" modified="2014-04-16" version="1">MYHPPTAQQDRNNPLGLPIYECWFCPTNWIGFSGLLFHLEEGRCVKQDRIRTLAFESPEYGFYGNRLTDQNPFFCFQCRAQFPQVSYLYHHAEHSPSCSYLLNPSECLGALRDFYVEYYECPGSDYIHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W6QNU3</accession>
    <name>W6QNU3_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">malate dehydrogenase</fullName>
            <ecNumber evidence="3">1.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">MDH1</name>
        <name evidence="14" type="ORF">PROQFM164_S06g000608</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(S)-malate + NAD(+) = oxaloacetate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21432"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.37"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the LDH/MDH superfamily. MDH type 1 family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.37" evidence="3"/>
    <dbReference type="EMBL" id="HG792020">
        <property type="protein sequence ID" value="CDM37646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QNU3"/>
    <dbReference type="STRING" id="1365484.W6QNU3"/>
    <dbReference type="OMA" id="MNPLVTE"/>
    <dbReference type="OrthoDB" id="4069699at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030060">
        <property type="term" value="F:L-malate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01337">
        <property type="entry name" value="MDH_glyoxysomal_mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000013">
        <property type="entry name" value="Malate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.110.10:FF:000001">
        <property type="entry name" value="Malate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.110.10">
        <property type="entry name" value="Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001557">
        <property type="entry name" value="L-lactate/malate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022383">
        <property type="entry name" value="Lactate/malate_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001236">
        <property type="entry name" value="Lactate/malate_DH_N"/>
    </dbReference>
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        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="MDH_euk_gproteo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11540">
        <property type="entry name" value="MALATE AND LACTATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11540:SF16">
        <property type="entry name" value="MALATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02866">
        <property type="entry name" value="Ldh_1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00056">
        <property type="entry name" value="Ldh_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000102">
        <property type="entry name" value="Lac_mal_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="LDH C-terminal domain-like"/>
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    </dbReference>
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        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0520">NAD</keyword>
    <keyword evidence="5 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Lactate/malate dehydrogenase N-terminal" evidence="12">
        <location>
            <begin position="3"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="Lactate/malate dehydrogenase C-terminal" evidence="13">
        <location>
            <begin position="148"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="179"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="8"/>
            <end position="14"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
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        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>substrate</name>
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    <feature type="binding site" evidence="9">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="118"/>
            <end position="120"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDM37646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="330" mass="34198" checksum="E49272BA20778785" modified="2014-04-16" version="1">MVKAVVLGAAGGIGQPLSLLLKASPLVDDLALYDVVNTPGVAADLSHISSVAKITGYLPKDDGLKLALTGADVVVIPAGIPRKPGMTRDDLFKVNAGIVKGLVESIAEFAPKAFILVISNPVNSTVPIAAEVLKAAGVFDPKRLFGVTTLDVVRAETFTQEFSGVKNASDATVPVIGGHSGETIVPLFSKVSPSFQIPADRYDALVTRVQFGGDEVVKAKDGAGSATLSMAFAGFRFAEAIIKASKGEKGIVEPTFVYLPGVAGGDEIAKATGLDFFSTPVELGPNGAEKAINILDGVTEQEKKLLEACIKGLQGNIEKGIEFAKNSPPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W6QNW0</accession>
    <name>W6QNW0_PENRF</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">PROQFM164_S07g000009</name>
    </gene>
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        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792021">
        <property type="protein sequence ID" value="CDM37661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM37661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="73" mass="8001" checksum="91D981B666A1682A" modified="2014-04-16" version="1">MAAYVDPRKPVADSEFSPLEDSRSFHDASSSSPGVATPSPSRCDCLAETPCQCAYEHEYSVHWCKIAQGCFGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W6QPB7</accession>
    <name>W6QPB7_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S02g001587</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1365484.W6QPB7"/>
    <dbReference type="OMA" id="IAMVIPP"/>
    <dbReference type="OrthoDB" id="4369561at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="42"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="58"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM31437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="228" mass="24467" checksum="1AA2BE2F7EEC6F4F" modified="2014-04-16" version="1">MEPSDSGVYESDSEPSQTSNLGEDPYSRANKASGRAEDPSTAEDTSATSSPSSPPPDRSTSTCSRARTTMSSKPPMRYPSIAMVIPPTSWKQGAARTSTRAAAAVCKKRLRSGRGTSIHQDGNTTYDTAQPCQKRKKRRPSIRPLFDPSESSVPISSHCSGAIQGVRGSAILTVESNTGLKPAYFFTFVPDPSPMLSRAHTAVIPGKHTYTSDENALLVRLKEKEAMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>W6QPI7</accession>
    <name>W6QPI7_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">histone acetyltransferase</fullName>
            <ecNumber evidence="3">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PROQFM164_S07g000255</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acetyltransferase family. GCN5 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="3"/>
    <dbReference type="EMBL" id="HG792021">
        <property type="protein sequence ID" value="CDM37906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QPI7"/>
    <dbReference type="STRING" id="1365484.W6QPI7"/>
    <dbReference type="OMA" id="RIVYTHY"/>
    <dbReference type="OrthoDB" id="1937912at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000123">
        <property type="term" value="C:histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010484">
        <property type="term" value="F:histone H3 acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05509">
        <property type="entry name" value="Bromo_gcn5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018359">
        <property type="entry name" value="Bromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037800">
        <property type="entry name" value="GCN5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45750">
        <property type="entry name" value="GH11602P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45750:SF3">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00633">
        <property type="entry name" value="BROMODOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="11 16" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7 12" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="5" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4 16" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="15">
        <location>
            <begin position="73"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="14">
        <location>
            <begin position="316"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="32"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CDM37906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="412" mass="47190" checksum="2E246270021486E7" modified="2014-04-16" version="1">MIDTESLSSSADSREALLAKRTSSEAPSLTPEAERIEDSRDSSTTPDVQPPAPIGRVPFPDKPAVLEERNGEIEFRVVNNDGSRESTIILTGLKCLFQKQLPNMPKEYIARLVYDRSHLSIALVKMPLEVIGGISYREFRERKFAEIVFFAIESDHQVKGYGAHLMAHFKDYVKATSPVMNFLTYADNHAIGYFRKQGFTKDITLDRSIWMGCIKDYDGGTLMQCSMIPRIRYLEAGRMLLKQKESVLAKIRTFSKNHVIHKPPQQWANGVITPLDPLSIPAIRETGWTPAMDELERKPCHGPHFNELRRFLNQIQNHEHAWPFVKPVDKDEVPDYYDVIVSPMDLSTIEGRLEQGFYSTPEKLVEDCRLIFSNCRQFNGTTTVYTKCANKLENFMWKLIEEIPEWNGLLDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W6QPY3</accession>
    <name>W6QPY3_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S13g000023</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792027">
        <property type="protein sequence ID" value="CDM38500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QPY3"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM38500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="101" mass="11482" checksum="B27DA2C9D37E6969" modified="2014-04-16" version="1">MLWKAESSAWHFQDMVFLSYGVLSEEPSHVLSGSSTPSDTHPALQCKRFQIHAQQIVGDTLVMILSNRRQGPWTERISAASPANTWGKYTHRGLKKKRPEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W6QPZ3</accession>
    <name>W6QPZ3_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidase S41A/B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S08g000112</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792022">
        <property type="protein sequence ID" value="CDM38061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QPZ3"/>
    <dbReference type="STRING" id="1365484.W6QPZ3"/>
    <dbReference type="OMA" id="MPLYVPN"/>
    <dbReference type="OrthoDB" id="43744at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011659">
        <property type="entry name" value="WD40"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32161">
        <property type="entry name" value="DPP6 N-TERMINAL DOMAIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32161:SF8">
        <property type="entry name" value="DPP6 N-TERMINAL DOMAIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07676">
        <property type="entry name" value="PD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004879762" evidence="1">
        <location>
            <begin position="20"/>
            <end position="660"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM38061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="660" mass="72685" checksum="8A8926107569499D" modified="2014-04-16" version="1">MHFPASIALLGLALPSALALCPYAEQMNLEKRNTPSPHAHEPRKAASSDKKGIFYMNRIAPGTSELYVANVDGTDERPLLSNSIYEYHATFSPDGEWITFTGERNGDGNSDIYRVRTNGSDLEELVATSSVEDGAVVSPNGKQVAYVSTANGYKANIWVLDLESGKKWNLTDTVSTAANTSLPDGYFRPSWSPDGQWIAFSSDRNTGWYGHGDPIFQGVTGWEHTQELSIYAIRPNGSDFRPVVSKSGYCLGSPKWSPDGERIVYYEMTRENTWNAHRPESLNSANSSIVSVEFATGANRRVEAEGTGVKLFPQYLPNGTIAYAGKGSGIEGLHTTAGGYVNTTSEIIRSPAWSPDGKKVVYEKNAWTIRPMDKKLYSWDTEWEYRFTDVFPQLSSTNKIALTEKQLGNSSIVSFNANGTDESLVYNDMESDFIDASSVAKGTAGAFNPAWSPDGKWVSFGVGFWFQGRATGGGWLSTTTLSSNSSVINSGFPSFSHDGKKIVFRIWGTNSTLGDRSQLGLRVLDLETRKTTVLTNEWDNLPSFSPDGKRIVFTRKTSDYNYDICTMRPDGTDVKVLTSSGANDAHAIWTWDGRIAYSSGMFGFQYECALYDQTFQPYGQVVVMNADGSNKRVLTDSIWEDSMPLYVPNSALKANAKVHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>W6QQM3</accession>
    <name>W6QQM3_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Positive regulator of purine utilization</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">uaY</name>
        <name evidence="10" type="ORF">PROQFM164_S10g000070</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792024">
        <property type="protein sequence ID" value="CDM38256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QQM3"/>
    <dbReference type="STRING" id="1365484.W6QQM3"/>
    <dbReference type="OMA" id="HANPQMP"/>
    <dbReference type="OrthoDB" id="5373550at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14723">
        <property type="entry name" value="ZIP_Ppr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.240.10:FF:000006">
        <property type="entry name" value="Positive regulator of purine utilization"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052202">
        <property type="entry name" value="Yeast_MetPath_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782:SF1">
        <property type="entry name" value="PYRIMIDINE PATHWAY REGULATORY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="68"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="147"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="257"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="364"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="805"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="24"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="48"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="178"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="364"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="805"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="884"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="924"/>
            <end position="939"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDM38256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="1038" mass="114608" checksum="143274224DCA171F" modified="2014-04-16" version="1">MPNPPSPLSPVSSGKKRPHPSNTPPAQTDPATNSASNLSAPTAVPSTSPAHSIVPASSASSSFRNVSACNRCRLRKNRCDQRLPRCQSCEKAGVRCVGYDPITKREIPRSYVYFLEARVAHLEKQLADNNIEIKKVVAFDEEEAIKLEADGDAAQPRPGSDGQAGEGSAAEKAQWRNTSKENAGRLERRGEGGNRDADDDPANEDNWRLHNLVSNIGMVSVQGTSDPRYLGSTSGISFARVVFAAVRSSLPGNIPDRAIRTSDRLPQSAAGTAGGGGSMRDSFFGLQTRPMMKCATFPDRELAERLVDLYFEHANPQMPILHRGDFMELLDKTYLLEEKKRSPRALYVLNIVFAIGAGIIFEDKPQSSDDESRSSRERPSSGTKRPRLSSHQYQPEEYHASAIIHLESFLGSSSSEGFGGLEELQAVLLLASFALLRPVAPGLWYIVGVAMRLAVDLGLHYEDGAGIDSATKDGNQAQSRIDARERGRREWVRDIRRRLWWCVYSFDRLVATCVGRPFGISDQAISTEFPSMMDDKYITKSGLLTPPDGASTYKHVAFHYFKLRLLQSEIHDVLQYQQARAVRRRGAGAVILPHAELSSPFLQGFDSFRSWRYDVHRRLVEWQDTAPTRPETGVRFSIELLELNYWQAIILLYQQSLTVPAELVGELTPADDVSSPSFSNPDEGEDEDQVYLNVAEAGQKVIRIYRQLHRVRLVNYTYLATHHIFMAGISFLYAIWHSPLVRSRLTLDEVDFTVLAATSVLGDLMHKCPPAEACRDAFERMSKATVQMCLSTTGFGSQVDISRVHATSNSSSSLHPGRPRQHMDQRHRAGQGQIRRATPARPSRPVPKFDMNLADLFTDNTPLTDHTRSENRPAGPSYPPQESVAPNFTADQSSRSYGQRNPSMDYYPKYENPSSPQPHPQFYYANSPQQSASPGSNTHGHALPPAETETPQGMSLDFLDFASGDAEGHGNMEGEANPDYNTMAAPSLGHNLGQNVGIDLGFGMAMDFQHDWSENPNYDLLEGYFFGGSGAGASGGDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W6QRB6</accession>
    <name>W6QRB6_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major facilitator superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PROQFM164_S05g000437</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QRB6"/>
    <dbReference type="STRING" id="1365484.W6QRB6"/>
    <dbReference type="OrthoDB" id="2962993at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF24">
        <property type="entry name" value="NICOTINIC ACID PLASMA MEMBRANE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="164"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="198"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="231"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="300"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="338"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="366"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="392"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="458"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="72"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM36604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="510" mass="56336" checksum="809550AC205341F0" modified="2014-04-16" version="1">MIVFPPEASDFLQNLSPVQAVPMDFDIKTEDTKTTVIDTEVSIAARSNEASSTIYIDPQKEAAARRKFDKYLVPVSLIFIILSALDRNNIGNAVIFGFEQDLGLVGNQFNNIQTLSSFCSFAGELPWTLVVRRFGARKALGTAFLLWSICTLGTAFIHTYGQAIAVRMILCACEGGLSPGFAFVYSTIYPKEQAGKRIMTTNLAQCIAGAFGGLFAYGIQTMGTRRGLAAWRWLFIVEFCFTIFIGGIGWIFIPDSAETAWYLNEEEKETMRLKRERDYVLRGEAKFDWKWARESLKDPFVYFLGIAFFTSSVAINGFGVFLPSIINGLGYTSLQANYMTIPVYVLGAISLLTQVYFSDKLKRRSLFIIGCCVPVAVGYLICVGTSSSGAGYAGMFILVLGLYPISTLAVTWATNTFAPDSKRAISMPMVYTMADISSMVSSQLYPSTQKPRYIQGNAVSAGLTCVAGLLYTACWYLLRRRNMKKKKLLAEGATSNGLEGDRSLDSMYML</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W6QRK9</accession>
    <name>W6QRK9_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7770 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S05g000527</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QRK9"/>
    <dbReference type="STRING" id="1365484.W6QRK9"/>
    <dbReference type="OMA" id="GIQKRWP"/>
    <dbReference type="OrthoDB" id="416217at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056672">
        <property type="entry name" value="DUF7770"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24968">
        <property type="entry name" value="DUF7770"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7770" evidence="1">
        <location>
            <begin position="47"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM36694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="189" mass="21781" checksum="A9D6E3691566B2AE" modified="2014-04-16" version="1">MLINEFFQNFPMEWDPIEFKPLSERDEILNEPLDCIRAICLPPLDPNSANRWTFFLSTSEVNMTAIRLNCGPSFSQDSTILDDGSKAIISFERRATLVPPERELILTLSVHPGYTVGDIYDMIVVNNRHKFEIDNFAEDSRIWVHDQLQLFDIYGVFSDEDEIELAMESVNSRWPGDIPDPVEEGVYYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W6QTL1</accession>
    <name>W6QTL1_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S02g003028</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QTL1"/>
    <dbReference type="STRING" id="1365484.W6QTL1"/>
    <dbReference type="OMA" id="DIMHHIC"/>
    <dbReference type="OrthoDB" id="4311059at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM32877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="101" mass="11644" checksum="B46574B6680B774D" modified="2014-04-16" version="1">MEGKIAVDSDYYTLTKDWEPEDFQSETTSIASTIAKGRLENGRRYQAMKEDDYWSPSDDQQFEAFEIGHMVFLVLDHDRENPLHHSPIGKSPKHILDIGTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W6QTS9</accession>
    <name>W6QTS9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S02g003098</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QTS9"/>
    <dbReference type="OMA" id="WIFREKV"/>
    <dbReference type="OrthoDB" id="5419802at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM32947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="230" mass="26023" checksum="135EDAE639968982" modified="2014-04-16" version="1">MPILLQIQLEYVASTVAQRLDSLEIDYAIMGGASVCLMAPDPQRATEDIDMVIQVDHRSITADLLTGILLKSFPSDFGPVNQFGHTIPGFKLQLPGDAVRLIELEIFDYASWPNRPQYDLQSATRVTQEINGYPVKIFSAEWIIREKILSQYQRRGAKQAVDQQDVENLLSYAIPGKPELDFDRDQELQDALATFLQRKPKLRSDLEEVIKCQAIFGNWCDSSILFSSDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W6QU15</accession>
    <name>W6QU15_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Tryptophan--tRNA ligase, mitochondrial</fullName>
            <ecNumber evidence="3">6.1.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Tryptophanyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">MSW1</name>
        <name evidence="13" type="ORF">PROQFM164_S06g000596</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>tRNA(Trp) + L-tryptophan + ATP = L-tryptophyl-tRNA(Trp) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24080"/>
            <dbReference type="Rhea" id="RHEA-COMP:9671"/>
            <dbReference type="Rhea" id="RHEA-COMP:9705"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78535"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.2" evidence="3"/>
    <dbReference type="EMBL" id="HG792020">
        <property type="protein sequence ID" value="CDM37634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QU15"/>
    <dbReference type="STRING" id="1365484.W6QU15"/>
    <dbReference type="OMA" id="GWGQFKP"/>
    <dbReference type="OrthoDB" id="15808at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004830">
        <property type="term" value="F:tryptophan-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070183">
        <property type="term" value="P:mitochondrial tryptophanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00806">
        <property type="entry name" value="TrpRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000082">
        <property type="entry name" value="MSW1p Mitochondrial tryptophanyl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.240.10:FF:000002">
        <property type="entry name" value="Tryptophan--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.240.10">
        <property type="entry name" value="Tyrosyl-Transfer RNA Synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00140_B">
        <property type="entry name" value="Trp_tRNA_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002306">
        <property type="entry name" value="Trp-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024109">
        <property type="entry name" value="Trp-tRNA-ligase_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050203">
        <property type="entry name" value="Trp-tRNA_synthetase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00233">
        <property type="entry name" value="trpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43766">
        <property type="entry name" value="TRYPTOPHAN--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43766:SF1">
        <property type="entry name" value="TRYPTOPHAN--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01039">
        <property type="entry name" value="TRNASYNTHTRP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12 13" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 12" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00069760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDM37634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="388" mass="43385" checksum="7D7BE71D5C45691D" modified="2014-04-16" version="1">MSANAMRHEFASPRPLRAKHLYIRPSGLSLLPRRCHRWNSSSITPPAQEPVIFSGIQPTGVPHLGNYLGALHQWVKLQQDATEGTKLFFSIVDLHALTVPQDPAQLKKWRKEAFATLLAVGLDPKRSTIFYQSGVPAHTELMWILSTVASMGYLSRMTQWKGKLQLPDDATLDDSTARAQLRLGLFSYPVLQAADILLHKATHVPVGEDQRQHLEFSRYTANSFNHLYGPIFPIPEALISPAKRVMSLKEPTSKMSKSHADGKSRIILTDSPAEIRKKVKVALTDSEASITYDPICRPGVSNLIEILSHLEGVSCEDIAAEFHNASLRSFKEHVADRIIHHLQEIRDRYITIMDDQTGYLESVAEEGAEAARANSRMTMQQIRDAMGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W6QU96</accession>
    <name>W6QU96_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acyl-CoA N-acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S02g003253</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM33102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QU96"/>
    <dbReference type="OMA" id="YGVQKLG"/>
    <dbReference type="OrthoDB" id="630895at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051531">
        <property type="entry name" value="N-acetyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43792">
        <property type="entry name" value="GNAT FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G00765)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43792:SF16">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="18"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM33102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="204" mass="22706" checksum="3B56CD3FFB364D11" modified="2014-04-16" version="1">MGSLFEASPTFSIESERLQISYFFPDSTEHCLFLMKLWNTEEFMKTCGRTSITTAEKASNFLRHRVHADYARNNYGMFLVSLKPHAHASLAESTPIGTVSLMRGEPPNAYLVPDIGYAFLPEETGKGYATEAALALLAYAKRELGVDSVFGFCGKDDTHSARVLEKIGLEFRGQRKLKVFGGKECAVWALPKMSQDLTVYGLDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W6QUL5</accession>
    <name>W6QUL5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Methyltransferase type 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S02g003384</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM33232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QUL5"/>
    <dbReference type="STRING" id="1365484.W6QUL5"/>
    <dbReference type="OMA" id="RTELWLM"/>
    <dbReference type="OrthoDB" id="10256176at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF103">
        <property type="entry name" value="METHYLTRANSFERASE TYPE 11 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="2">
        <location>
            <begin position="788"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="348"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="545"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="556"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM33232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="1018" mass="112323" checksum="A6EFD4760E03F535" modified="2014-04-16" version="1">MTDILRISTVRFPPPRQARGTVLNTIMEDTRESNFAQTSPKGSPPSRLTPAAISPQLKLQTSGFSVPTHARLARLMSPLSAGTTSSCSDTEWQAQMQEFRGYDDFYDATDDDSIDDNETEMSDSCFSPDTRPSSLITPITRNSVTSTGSSRKRSLTLEIPSSALWPSITGSLKGSPVPPTPPSKIPVSPAALSMLSRSVPASYAPPSLDGSMTSDQESIISALATPDSQSLPDTNWDAHDIHVRRDLDGSESDLDNADSSSDIHTVPIAIETQHEDWRHVLGSFPRIPTAAQAYSPPLSPSSSPSFHLNNEPIYEYDDLYDAPQSIDQGAFLPNSALAMLHHVHLEETPDSCSETSEDKGEMWQLQPPPSRPRSADGVTPASELSGYSFSDLSIPSPGGFFASLAPRARHTWSIPNTNYQPSSAAAEGFYNLPWRRDDGDIVEQVVEWHEPPVDENPVTAVRDEEAPLTAIRLPCDTPTRRSIYQDSPMSAAFDAVQVQEIPRSGNGYEYDECYDQELQERAVASHDRTNIWLSAQASYLSALSETNPANDVEPVESPKESDSIEVEAKDTTEESTTKMVRFVEGVPESLSPLPPILASKDSIYWRGFQSIREQSTKTDGFMHRNMRFDAVQSMRLAMNDLHINCLLGKYELVRPERPAYKGPFAKAPRNSTITSELAEKAKFDKVEKEQLVLAQLSQPMWAMDALRSLNGGNLLTSPAQRMLAQTSSKPKASQGPRKRSFRILDLGGQSSCDWAWQAAYEFPNVKVYTVASKNQTVNSAIKGPPNHRQVNVDNLWELPFGNNQFDVISARSLHALLKTECPAGKDRDEYDLVLKECMRCLKPGGYLEFQVLDAEISRAGPYASATSVEFAFNLRNRGYDPVASKSFVARLRNSGFVDTQRAWMVLPMGTEHVEQEPMRETPAPRVQSQIEDYEAVQGPIGSTADIASITGLIGGWMWEQWLLKLRVEMGRERPMLLEGLGALFDEGRKSGAGWTCLSGWTMKPKRKSSVSLAETGSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W6QWB5</accession>
    <name>W6QWB5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Manganese transporter SMF1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">SMF1</name>
        <name evidence="7" type="ORF">PROQFM164_S12g000063</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792026">
        <property type="protein sequence ID" value="CDM38454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QWB5"/>
    <dbReference type="STRING" id="1365484.W6QWB5"/>
    <dbReference type="OMA" id="PRWLNYF"/>
    <dbReference type="OrthoDB" id="409173at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015086">
        <property type="term" value="F:cadmium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005384">
        <property type="term" value="F:manganese ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030026">
        <property type="term" value="P:intracellular manganese ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034755">
        <property type="term" value="P:iron ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001046">
        <property type="entry name" value="NRAMP_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01197">
        <property type="entry name" value="nramp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF037982">
        <property type="entry name" value="Nramp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11706:SF101">
        <property type="entry name" value="MANGANESE TRANSPORTER SMF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11706">
        <property type="entry name" value="SOLUTE CARRIER PROTEIN FAMILY 11 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01566">
        <property type="entry name" value="Nramp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00447">
        <property type="entry name" value="NATRESASSCMP"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="207"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="241"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="271"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="392"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="436"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="483"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="513"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="578"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="16"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="47"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM38454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="604" mass="65084" checksum="79BA1C18706C1588" modified="2014-04-16" version="1">MNKTSHTDEPLEGDGYNQNPNPNSKDLTTNEDFNGLVNSRAVRESDSQALSNAASNASGEIASHAPIQKDGHGKATYRLAQRSIDRGQPPEGGMQVPVTAHPPGFPPASAGGDADPGTLIQRARKMLATFGSFIGPGFMISVAYIDPGNYSTDIAAGASYRFRLLFVVLLSNIFAIFLQSLAIKLGTVSGLNLAEACRAFLPRWLNYILYAFAEAAIIATDIAEVIGFAIALNLLIPKVPLVAGCAISILDVMVTLFFYHPEGSMKGLRYFEIFIICLVLAVVVCFCIQLSLIRGTMPGEVFKGYVPSKYLIESEAIYQACGILGATVMPHSLYLGSGIVQPRLREYDERSRLLPRQLASGYSVLDDGIDKGYYVPSFSAIKHSLTVSILELAISLFTFALFVNSAILIVAGAALYNNPDALDADIFGIHDLLSKSISPAAGIIFALALLLSGVSAGIVCTIAGQMVSEGALNWNIRPWLRRLVTRTISITPSIIIAGAVGREGLNAALNGSQVALSIILPFITAPLIYFTCRDKYMTAYPGKARWRMAGRDDESDVDQVIGEGAELEPEGVKMTNSWYTMILAVLIWLFMSIMNVANLVFLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W6QWD5</accession>
    <name>W6QWD5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S12g000078</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792026">
        <property type="protein sequence ID" value="CDM38469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QWD5"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM38469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="52" mass="6050" checksum="64E127CB4B5C5000" modified="2014-04-16" version="1">MIGITSSLSAYPLAHEFALAAKQLLCFECRRYRCRLKGWASQILDMLDMRRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W6QX38</accession>
    <name>W6QX38_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">N-terminal methionine N(alpha)-acetyltransferase NatC</fullName>
            <ecNumber evidence="13">2.3.1.256</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">N-acetyltransferase MAK3 homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">NatC catalytic subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PROQFM164_S03g000826</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>N-terminal L-methionyl-L-isoleucyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-methionyl-L-isoleucyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50524"/>
            <dbReference type="Rhea" id="RHEA-COMP:12713"/>
            <dbReference type="Rhea" id="RHEA-COMP:12714"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:133379"/>
            <dbReference type="ChEBI" id="CHEBI:133380"/>
            <dbReference type="EC" id="2.3.1.256"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N-terminal L-methionyl-L-leucyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-methionyl-L-leucyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50520"/>
            <dbReference type="Rhea" id="RHEA-COMP:12711"/>
            <dbReference type="Rhea" id="RHEA-COMP:12712"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:133377"/>
            <dbReference type="ChEBI" id="CHEBI:133378"/>
            <dbReference type="EC" id="2.3.1.256"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>N-terminal L-methionyl-L-phenylalanyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-methionyl-L-phenylalanyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50528"/>
            <dbReference type="Rhea" id="RHEA-COMP:12715"/>
            <dbReference type="Rhea" id="RHEA-COMP:12716"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:133382"/>
            <dbReference type="ChEBI" id="CHEBI:133383"/>
            <dbReference type="EC" id="2.3.1.256"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>N-terminal L-methionyl-L-tryptophyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-methionyl-L-tryptophyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50560"/>
            <dbReference type="Rhea" id="RHEA-COMP:12724"/>
            <dbReference type="Rhea" id="RHEA-COMP:12725"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:133386"/>
            <dbReference type="ChEBI" id="CHEBI:133387"/>
            <dbReference type="EC" id="2.3.1.256"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N-terminal L-methionyl-L-tyrosyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-methionyl-L-tyrosyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50532"/>
            <dbReference type="Rhea" id="RHEA-COMP:12717"/>
            <dbReference type="Rhea" id="RHEA-COMP:12718"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:133384"/>
            <dbReference type="ChEBI" id="CHEBI:133385"/>
            <dbReference type="EC" id="2.3.1.256"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the acetyltransferase family. MAK3 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.256" evidence="13"/>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QX38"/>
    <dbReference type="STRING" id="1365484.W6QX38"/>
    <dbReference type="OMA" id="LCIFARH"/>
    <dbReference type="OrthoDB" id="249099at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031417">
        <property type="term" value="C:NatC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120518">
        <property type="term" value="F:protein N-terminal-methionine acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000010">
        <property type="entry name" value="Putative N-alpha-acetyltransferase 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044542">
        <property type="entry name" value="NAA30-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45896">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45896:SF1">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 17" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 17" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="16">
        <location>
            <begin position="10"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00050754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00051225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00052207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00052362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00052477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00066994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00076746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00078622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CDM34102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="199" mass="22775" checksum="F69E4D61F67C2D93" modified="2014-04-16" version="1">MSNAPDLRYVRYENSREKEYVAAMRQLISKDLSEPYSIYVYRYFLYQWGDLCFLAMDDKDEMVGVVVSKLEPHRDGPLRGYIAMLAVREEYRGRGIATKLVRMAIDAMIERDADEIVLETEITNTGAIKLYERLGFLRSKQLHRYYLNGNSAYRLVLYLKEGVGAIRTALVDPYGLPPPVPGLPDRCEGHSHANMGSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W6QZ31</accession>
    <name>W6QZ31_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Genomic scaffold, ProqFM164S03</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S03g001509</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QZ31"/>
    <dbReference type="OMA" id="MSSHPLE"/>
    <dbReference type="OrthoDB" id="5423884at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="55"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM34782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="212" mass="23292" checksum="A56148024CBF9271" modified="2014-04-16" version="1">MSSLPLDTFDLDPTKPNLNARDLNANLLHTDTSLQKRYTTISIPSTYGRLQTSPAAGTVVGIILGSVAGFVLLMYVLFLAVNPGGIARGGVAAPTSSSISMSMSMDEEEVVEVRKRRGSSAGRRRRDIIEVEEREGFRDSYRRRPTSRHDRVVVEESLATSTTGEDVIEVEEEESSVPSDISPRPPRRSRRSGIRHVDPMAYGGGSDYSNHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W6QZE2</accession>
    <name>W6QZE2_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Concanavalin A-like lectin/glucanase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PROQFM164_S03g001649</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cclA family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QZE2"/>
    <dbReference type="STRING" id="1365484.W6QZE2"/>
    <dbReference type="OMA" id="GFRYTYA"/>
    <dbReference type="OrthoDB" id="10266026at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12872">
        <property type="entry name" value="SPRY_Ash2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037353">
        <property type="entry name" value="ASH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10598">
        <property type="entry name" value="SET1/ASH2 HISTONE METHYLTRANSFERASE COMPLEX SUBUNIT ASH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10598:SF0">
        <property type="entry name" value="SET1_ASH2 HISTONE METHYLTRANSFERASE COMPLEX SUBUNIT ASH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0430">Lectin</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SPRY" evidence="5">
        <location>
            <begin position="210"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="543"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="32"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="53"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="589"/>
            <end position="598"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDM34922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="598" mass="64380" checksum="4BA32CC6E000D7D3" modified="2014-04-16" version="1">MASGQAPGSSAPSSNINSPILPPNGGPLLNAQFTDLNPRSSPAPSAQGDGRAKRNKRDSRKKREAKGLDPENAPPPKRRATAAPSTALPSSKLSILRPLLLAEPHDSDRYPPQPRQLNRVSRKTSNVLGQSWDFYEVVDKLTNKNGFRYSYAIADPGFPHIKYRQTDVHPYHTRFSFEDSPAAIFFSENATAVTTSDAWHTARANVCAREGTYYYEARVISGIVNDPQAPQNGRPTTSPRGHVRIGFARREADLDVNVGVDCYGYGIRDVNGEVVNRMRCEFFFPKGEAINEGDVIGMLITLPPLSLHKKIVEGTYDPTNNTPSPPMATNIIRDRIPFHYKSDFCWQQSNVFSTKHLRDYAFNLKETPTFGPPSPLNSEDATLRTLPGSSITILKNGVQMGTPFKELYAFLPPASRLANGTNNLGIGERENADDGLIGYYPAVSCYGGGAVECRFEGPWWVGPPKQTETGEPVRAMGERFNDQIAEDVMADIVDEVEAMFTWGGIDGDVIKNNTELDGAGVVGGAEVLKGGVGAALDSALAHTPGTAGASDSAANSNRETPAAGDVGSHGLEDAMSVGTAGTPNVEVQGDGDGDVEMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W6R093</accession>
    <name>W6R093_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">F-box domain, cyclin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S04g000113</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6R093"/>
    <dbReference type="STRING" id="1365484.W6R093"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004882043" evidence="1">
        <location>
            <begin position="22"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM35232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="79" mass="9014" checksum="7CED8A5D0D6DF5F3" modified="2014-04-16" version="1">MSLFSLPTELLLLLTHNLQYASELSAMSQTCRRFHTIFDPELYSRFANSCEFNILRLVETGNSDAIQKLGLLVTNCLIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W6R0I7</accession>
    <name>W6R0I7_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">alpha-galactosidase</fullName>
            <ecNumber evidence="2">3.2.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PROQFM164_S04g000208</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids.</text>
            <dbReference type="EC" id="3.2.1.22"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.2.1.22" evidence="2"/>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6R0I7"/>
    <dbReference type="STRING" id="1365484.W6R0I7"/>
    <dbReference type="OMA" id="ERWLNIK"/>
    <dbReference type="OrthoDB" id="2108802at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004557">
        <property type="term" value="F:alpha-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004352">
        <property type="entry name" value="GH114_TIM-barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35273">
        <property type="entry name" value="ALPHA-1,4 POLYGALACTOSAMINIDASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G07890)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35273:SF2">
        <property type="entry name" value="ALPHA-GALACTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03537">
        <property type="entry name" value="Glyco_hydro_114"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside-hydrolase family GH114 TIM-barrel" evidence="4">
        <location>
            <begin position="70"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="264"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="347"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="264"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="276"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="354"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="376"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDM35327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="429" mass="45675" checksum="BD7D1540206DD7C1" modified="2014-04-16" version="1">MMNSTQTSGWQVLVTKRKLLVSCVLGLFFLAIGMDLRAELGAGHNQKKILKRDTTSTSDATIWQPAAGVKWQIQLVDAVEDTSVDADIWDIDLFDNTAETITTLQGKGHKVICYFSAGTYEDWRSDISKFDSADFGSNLDDWPGERWLNIKSTSVRAIMSSRLDMAQQKGCDGVDPDNIDAYGNENGLGLTEADSIDFLTFLASEAHSRGMSIGLKNGGDIIGSVIDKMQWSVNEQCAEYNECDVYAAFTDVNKPVFHIEYSDETIESDSSDDTSDTATTTSTDGKATATATATVAVIPSSTSATAAAATATSVSVIPASTSATAASATATSLSVIPASTSAAAAAATSTAADDTNDDDEDDEDDDEEASTDNTKEKKHRHGHGHGNHNLRARAVLSSTLKTSACNAANAGKFSTVIKNMNLDAWVEYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W6R2B8</accession>
    <name>W6R2B8_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Solute carrier family 35 member SLC35F1/F2/F6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PROQFM164_S04g000868</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC35F solute transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6R2B8"/>
    <dbReference type="STRING" id="1365484.W6R2B8"/>
    <dbReference type="OMA" id="VRYHWAQ"/>
    <dbReference type="OrthoDB" id="429955at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009262">
        <property type="entry name" value="SLC35_F1/F2/F6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052221">
        <property type="entry name" value="SLC35F_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14233">
        <property type="entry name" value="DUF914-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14233:SF4">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER F2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06027">
        <property type="entry name" value="SLC35F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="67"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="138"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="290"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="319"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="345"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="406"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDM35987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="426" mass="47226" checksum="46F17234530C8715" modified="2014-04-16" version="1">MSESKDQITVQASGVEHGSSTNSLAKDAQTGAQSSSSQVEASECPVQPADLVDQKKGAFGYFKTKEFYITVLLGQILAIANTSTGTFTTLLGEEQWAIPAFQTFINYVLLNVIFTPYTMYRYGFKGWLRLVYRDGWKYIILAFCDVEGNYFIVLAYQYTTMLSAQLINFWAIVVVVVISFLFLGVRYHIAQIIGILLCIGGMGVLIGSDHITGTNGGDISQGNQLKGDMFALLAASFYGLTNTGEEYFVSTRPVYEVLGQMSFFGMIINGAQAGIFDRTSFHNAHWNGKVGGYLTGYTLCLSMFYCLAPLLFRLSSAAFFNVSMLTMNFWGVIIGVKVFHYHIHWMYPIAFVLIIIGQLIYFLAQKVLSEARKPWLGANQERGVVGLFTAKRKIVHVIPTAAEFQDQTQTPDDTSKHTPTVNTSAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W6R3S2</accession>
    <name>W6R3S2_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S05g000285</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6R3S2"/>
    <dbReference type="STRING" id="1365484.W6R3S2"/>
    <dbReference type="OrthoDB" id="7777654at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="37"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM36452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="123" mass="13977" checksum="F8E31D5D93708A2A" modified="2014-04-16" version="1">MRYLQPILLRYVYAPILAIVFSFAYPESYTLRYDPMVIAGFILAHFCLLLILLGLVFPRYYNVFIPPGRRTEGKEETIANQPKEQELLPEIGVLDCETGVQELVSDRKSSDGIDTGHSKGPRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>W6R4Q3</accession>
    <name>W6R4Q3_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">tRNA (guanine(46)-N(7))-methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.33</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PROQFM164_S05g000620</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>guanosine(46) in tRNA + S-adenosyl-L-methionine = N(7)-methylguanosine(46) in tRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42708"/>
            <dbReference type="Rhea" id="RHEA-COMP:10188"/>
            <dbReference type="Rhea" id="RHEA-COMP:10189"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:74480"/>
            <dbReference type="EC" id="2.1.1.33"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.1.1.33" evidence="2"/>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6R4Q3"/>
    <dbReference type="STRING" id="1365484.W6R4Q3"/>
    <dbReference type="OMA" id="LNVMKFG"/>
    <dbReference type="OrthoDB" id="47276at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043527">
        <property type="term" value="C:tRNA methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008176">
        <property type="term" value="F:tRNA (guanine(46)-N7)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003358">
        <property type="entry name" value="tRNA_(Gua-N-7)_MeTrfase_Trmb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23417">
        <property type="entry name" value="3-DEOXY-D-MANNO-OCTULOSONIC-ACID TRANSFERASE/TRNA GUANINE-N 7 - -METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23417:SF16">
        <property type="entry name" value="TRNA (GUANINE-N(7)-)-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02390">
        <property type="entry name" value="Methyltransf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51625">
        <property type="entry name" value="SAM_MT_TRMB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="29"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="29"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM36787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="228" mass="26033" checksum="8C00C476ED288FB1" modified="2014-04-16" version="1">MPDTLMVGMEIRTSVLEYVTSRIHALRSQQQRLKNKAANPSSTEPQDASTQPENTESAPAPTPANDDEIGTEKIFPGNFENIAAIRSNTMKFLPNFFGHHQLSKIFICFPDPHFKARKHKARIISESLNAEYAFVLRPGGLLYTITDVEEYHHWVLRHFLNNEQQEGEPAPAPSSKDLFERVPDEELALDPCVRVMKFETEESKKVTRNKGNKYVAVFRRKADPEWPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W6R4T9</accession>
    <name>W6R4T9_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mitochondrial import inner membrane translocase subunit TIM54</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">tim54</name>
        <name evidence="13" type="ORF">PROQFM164_S05g000665</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TIM54 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6R4T9"/>
    <dbReference type="STRING" id="1365484.W6R4T9"/>
    <dbReference type="OMA" id="RNWMIFF"/>
    <dbReference type="OrthoDB" id="5598305at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050187">
        <property type="entry name" value="Lipid_Phosphate_FormReg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021056">
        <property type="entry name" value="Mt_import_IM_translocase_Tim54"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12358:SF101">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12358">
        <property type="entry name" value="SPHINGOSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11711">
        <property type="entry name" value="Tim54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0811">Translocation</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="231"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="362"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="250"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="370"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDM36832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="499" mass="56152" checksum="1C656D2EB03A7A83" modified="2014-04-16" version="1">MADSSSSAAPEGAGKPPVAPKPPNPVFKMMGLPNMRFKLPSRNWMIFFTITGSFAGALIYDRREKRRVQQKWSELVAHISKETLPVDQMRRKMTVYLAAPPGDGLRVARDHFKEYVKPILVAAALDYTVVEGRREGDVRFNTAENIRKLRRKAGEPSSAPEEVGVDAVVAATRAHIGVTDEPGPKGDLIIGRHTWKEYIRGLHEGWLGPLDAPLPPAEELSVDLSQDVSAEKPASLAVPEIASIDSPEFSEEKKDEIPAPKIEEPEKEEKKEEEKPAKPAGPTPAYIYPSEYSSATLPNTIPQSFDSSTPVEFPHLLGFLNTPIRIYRFLTQRYLAEDVGRDVAALVLANSARPYREDTFIADSESTPASESTLSLDSSFTDLPPRNYEQQTVMEAAEIEWHKSVHKRDEDENVKEREWLDDIVLDPRIASRMQRATLSQEDEARSQRIAEQQEYILGEERPAHVPFWKRMWIDYGYGESDEVLRRKPILGNIDGEDEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W6R642</accession>
    <name>W6R642_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Zinc finger, C2H2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S06g000208</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792020">
        <property type="protein sequence ID" value="CDM37247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6R642"/>
    <dbReference type="STRING" id="1365484.W6R642"/>
    <dbReference type="OMA" id="MKHANIR"/>
    <dbReference type="OrthoDB" id="4485682at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021842">
        <property type="entry name" value="DUF3435"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37535:SF2">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G09300)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37535">
        <property type="entry name" value="FLUG DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11917">
        <property type="entry name" value="DUF3435"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="739"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="646"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="39"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM37247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="781" mass="90506" checksum="2A3762787798FE7D" modified="2014-04-16" version="1">MSDVTNLFSATDSDTSGESFQPDIDATDDSDSGQASNSTELTTPEPTCLPDNCNRPSTRPKRPVRRPADAGVLPDFSDDPDDDTDEDIANIPLDYGRSEQTKVRGRRIEKRWDKYCRVKAAQAGALLKWDDPVEALREVTPNDVHRFFNYCMKLKYGEGGRHLKGTSKASALKADWKGFRGYYRRITRTRITAEDSEEINAGIRKLVDKFDLDTQERGKEPVYVQDLTELNETILRTQERRFHFGYERIQLCLFNMLGIYTVNRLHALLSLQFHHLRFSIQDNPDGGPPVLLVEIKSEHTKRFLGTSQINNFPFPEIINDPSLVFSPHTFIFGILLWLQAFEVPTLSSMERLRKLFVQGGRQQMELPLKREVEGYYVFCKTDVINGRAVLQWNQPMTEGAMSGRLRNLGEIHGFLQSMFAHRFRYGGGKMLNESSAVSEAQQNLIMKHADTRTFLNHYLPRHIDTDMQNVMNGRESNKSLMRAITRMSRWIDKRRPRHLTSEQRASLREHPEYVEATRRMKEQAEECKCDPSAAMQSRLEKLKRETSNTFGRLERALRRKVRYEFDRKQAIIDIERQLSGAAVDDEEAKKVLQVEDQMLPEQIDLLEKLFTWPTSQSLEAEWQRRNAAVATISRYCGFLEGGPLRGRRKRAAPSDGFDEEQTSVLPEPAKKGCSSPEPSQQDILLVKAKNYIKKAKKPRRCFQCYGDTELPIHRRTQKYSEYKSTLRHFREKHLQDRRCHMCDEDLLHEMHLRRHAEEVHRLSTERNYYAKEDTGSDIDTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W6PQ86</accession>
    <name>W6PQ86_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Dyp-type peroxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PROQFM164_S01g000147</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DyP-type peroxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PQ86"/>
    <dbReference type="STRING" id="1365484.W6PQ86"/>
    <dbReference type="OMA" id="QQEAIIG"/>
    <dbReference type="OrthoDB" id="76259at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048328">
        <property type="entry name" value="Dyp_perox_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048327">
        <property type="entry name" value="Dyp_perox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006314">
        <property type="entry name" value="Dyp_peroxidase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01413">
        <property type="entry name" value="Dyp_perox_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30521">
        <property type="entry name" value="DEFERROCHELATASE/PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30521:SF0">
        <property type="entry name" value="DYP-TYPE PEROXIDASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20628">
        <property type="entry name" value="Dyp_perox_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04261">
        <property type="entry name" value="Dyp_perox_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51404">
        <property type="entry name" value="DYP_PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 9" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dyp-type peroxidase N-terminal" evidence="7">
        <location>
            <begin position="6"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="Dyp-type peroxidase C-terminal" evidence="8">
        <location>
            <begin position="138"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM26338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="309" mass="34106" checksum="8452697119A49119" modified="2014-04-16" version="1">MAPQRVDAPLTKFATFLVLSVTNKSNAIENVRSTLAGVDSLAKNVSIRDLSAQFACTVGIGSDIWDRLTGFPRPSELHPFREVKGEKHTAVSTSGDLLFHIRSERRDICFEFERQLLDQLGDSVSVIDETVGFRYFDVRDLLGFVDGTANPVGLAVPASVLVAEEDTAAAGGSYIVVQKYSHDLPGWKDLSTEQQERIIGRTKIDNIELDDAKSGQRSHKTLTTVEDEDGNEHDILRDNMPFGSPGSGEFGTYFIGYTRRLWVIERMMERMFIGDPPGLHDRILDFSKPLTGTTFFAPSASLLSSLGSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W6PSM6</accession>
    <name>W6PSM6_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Aldolase-type TIM barrel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PROQFM164_S01g001027</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NADH:flavin oxidoreductase/NADH oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PSM6"/>
    <dbReference type="STRING" id="1365484.W6PSM6"/>
    <dbReference type="OMA" id="AWRGNIM"/>
    <dbReference type="OrthoDB" id="1663137at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051799">
        <property type="entry name" value="NADH_flavin_oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43656">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G08260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43656:SF5">
        <property type="entry name" value="NADH:FLAVIN OXIDOREDUCTASE_NADH OXIDASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:flavin oxidoreductase/NADH oxidase N-terminal" evidence="5">
        <location>
            <begin position="9"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDM27218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="369" mass="40948" checksum="C921120B00512881" modified="2014-04-16" version="1">MSASHISPLAQPITLKLSGKVIRNRLYRTPLSEYASTYDENNVENCGKPMDRYAELYQKLADGGAGLICTGNIPIHRDNLENYNNAVLDPNNPWDPVAAFTPAAKAAKSRGAIFLPQLQFPGRQVPEFLNKNPKSSSDQQLEPCLNKTYGKPSPLTKAEIKDLISRYVWASEVLAEAGADGIILHASHGYIMNQFLSPKINKRTDEYGGSLENRARFILEIVNAIKAKLPSDKFVIAAKLNCQDFIEGGQSFAEQCVVIKWLEDAGVDFFDISGGTYASPAWRGNIMTELAERPSQKQRGSYFIEWAQELKKVLSRAVIGTTGGWRDSHRMAEAVERGDIDMCGLGRPLREDPAFVNKVLQGEIRRSNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W6PTA4</accession>
    <name>W6PTA4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g001239</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
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        </source>
    </evidence>
    <sequence length="1204" mass="130749" checksum="83610B1244DFA8D1" modified="2014-04-16" version="1">MSVPPFTVRSVFEYASGHDDDLNFPIGQIVTVTALEDDDWYYGEYSDAQGARQEGIFPKNFVEKYEPPAPPRPSRPRPKKEPETLPVESPVVESKQAEREPEPAVQPTEEDYGIQSSQPLPQSPRLHASAPVSEVVSSPPQPAKAPAPAHPVAPTESAAKAPSKPAPPAVADKPSGSSFRDRIAAFNKPAAAPVTPFKPGGSQPSFVKKPFVAPPPSRDAYKPPPREPAPKIYKREEDPDVKEQIAREPPVSESRPAHIEGGEEGAEDQPKPTSLKDRIALLQKQQLEQAQRHAEAAQKKEKPSRPPKKSMDEPVAPAVLDEVQEPPSVEEPPATRDTSVDTLRAAAPPSQPPAPFSPTQEVASDANDADYSAAADSEDAGETSTSKDDEEDQAQPRPVSRRQPLTHAVEQTAEADVEDEGDAEEEEEEEMDPETKRRMELRERMAKMSGGMGMMGLFGPPIGGMPGMPGMASAGSARKPKTPVESEKRLGELESEPTSPANAPPVPMIPLPGMNAASKPVPSYTEVEKEEEEPLATPLTEQHPARDVPDVEEVVHEGALPRTSIDRPAPAPPSQDRSAPPPPHRESRPVPTVPVEPPASPPPVPAGRPAPPLPRPTTADKGEESDDELSVHTSTLSLNNSPAPPPVPTHAVHEHIDSRRSSIYDPMPSTASTPAAEKRASRLPPPIPVNPPMPPSAQGRAPPPLPSDQLRRRSTVDSRTSALSAPRQAGEEAEGEVTEYDGDYDTDIASGVKHKDALKAHERESSFDEGIFTDDYSIQSPRSPQESRHHHLPPPPPTAPRAVPPPPPSQPPRNARASIDTPRGPPPPPPDREPNSDDDVEYDPFNYAAPRHGLPASPPVPVGRPGPPPPFPTQAADEFDDLYDAPPVQSPVRERSDKRLSLALPQGQASGLPSPSAARTQRASVDILRSQPNLRRSMDVSRPSIDQGYIATDVDFAAYTLWWTKPKTPPPAFQNRTDLLFEVEETASTNRSGKTTVSKDVYILFIDYSQTVLNVQFDPKNPKDASFEQRHEPPPLPSRQDQLEQAHIQLGTRISEAVNSVQNSTVGDGTPFGLVQHLLSPLSDALLPVGTRAYGASVYSNLANASVSQNDEIRAGDIVSFRNARFQGHRGTMHQKYSAEVGRPDHVGIVVDWDGTKKKIRAWEQGRESKKVKMESFKLNDLRSGECKVWRVMPRSWVGWEASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>W6PVT8</accession>
    <name>W6PVT8_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Mitochondrial inner membrane protease subunit</fullName>
            <ecNumber evidence="11">3.4.21.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PROQFM164_S01g002144</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S26 family. IMP2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.-" evidence="11"/>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PVT8"/>
    <dbReference type="STRING" id="1365484.W6PVT8"/>
    <dbReference type="OMA" id="VNMWPWG"/>
    <dbReference type="OrthoDB" id="9996127at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042720">
        <property type="term" value="C:mitochondrial inner membrane peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006627">
        <property type="term" value="P:protein processing involved in protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.109.10:FF:000023">
        <property type="entry name" value="Mitochondrial inner membrane protease subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.109.10">
        <property type="entry name" value="Umud Fragment, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037730">
        <property type="entry name" value="IMP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000223">
        <property type="entry name" value="Pept_S26A_signal_pept_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02227">
        <property type="entry name" value="sigpep_I_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46041">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE PROTEASE SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46041:SF2">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE PROTEASE SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10502">
        <property type="entry name" value="Peptidase_S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="LexA/Signal peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="3 11" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Peptidase S26" evidence="13">
        <location>
            <begin position="72"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="100"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR600223-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF10502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDM28333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="269" mass="31077" checksum="CD06844BBAAC8073" modified="2014-04-16" version="1">MSKPHRPRGIPTPNSRYRVQVHEEPKPKIPDPITYEGPSLSKKRTPFISHFFTNLRQRLSALPYPVRRACRTLSWAVPMLPIALFIPEHVMQVMWVRGPSMTPYLNEEYEQTHTKSDMVMVNMWPWGSILPFKKERKLERGMIVTFRSPANPSHIAIKRIVGLPGDRITTREPCLRKTQIVPWNHVWLEGDAEDPRKTLDSNTYGPVSLSLITGQVFAVLGPRMRWLNWTDWDSDKGKGESASDDAAYRQSVRDRVLKDAVQLEQPFLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W6PW23</accession>
    <name>W6PW23_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein FYV10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Protein fyv10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">fyv10</name>
        <name evidence="14" type="ORF">PROQFM164_S01g001921</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the proteasome-dependent degradation of fructose-1,6-bisphosphatase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FYV10 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PW23"/>
    <dbReference type="STRING" id="1365484.W6PW23"/>
    <dbReference type="OMA" id="ANHETAR"/>
    <dbReference type="OrthoDB" id="1933455at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034657">
        <property type="term" value="C:GID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013144">
        <property type="entry name" value="CRA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024964">
        <property type="entry name" value="CTLH/CRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006595">
        <property type="entry name" value="CTLH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045098">
        <property type="entry name" value="Fyv10_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044063">
        <property type="entry name" value="ZF_RING_GID"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12170:SF2">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN TRANSFERASE MAEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12170">
        <property type="entry name" value="MACROPHAGE ERYTHROBLAST ATTACHER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10607">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00757">
        <property type="entry name" value="CRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00668">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50897">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51867">
        <property type="entry name" value="ZF_RING_GID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CTLH" evidence="12">
        <location>
            <begin position="164"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="RING-Gid-type" evidence="13">
        <location>
            <begin position="329"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="RING-Gid-type" evidence="10">
        <location>
            <begin position="329"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="73"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDM28110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="406" mass="46176" checksum="E6CDA19DFD00D508" modified="2014-04-16" version="1">MAAELTSTKLNPESHIILDQPLLRLPLELARRNFKTVQRAVEREKEYVIPAIKEAAAASLSNTQTPEQTLAALDAMISRMQSLKRKMEGLQEEEKKIHSQSRKRIQHLETLHKIPSLADVKYDQWSRVRLDRLLVDHMLRSGYSESAKQMAQDRGVEDLVDLGVFTQAKRIVDSLRRGETKEALQWCGENKAALKKSPQNLEFELRLQQYIEMVRTQDKSKRIEAIIHAKKYLIPNYQAQNSDIMRAAGLLVFTQDTRAEPYKSLFARERWKFLADLFIETHHELLSLPAQPLLHIALSAGLSALKTPLCHSAYTSSSSNSQSTSTSVCPICSTELNELARNMPYAHHSKSYVESDPIVLPNGRVYGKQRLIEMSRNMGTVKPGDVKDPTTGQVFHEGEMKKVYIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W6PW26</accession>
    <name>W6PW26_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Amine oxidase</fullName>
            <ecNumber evidence="14">1.4.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PROQFM164_S01g001797</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a primary methyl amine + O2 + H2O = an aldehyde + H2O2 + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:16153"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:228804"/>
            <dbReference type="EC" id="1.4.3.21"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>L-topaquinone</name>
            <dbReference type="ChEBI" id="CHEBI:79027"/>
        </cofactor>
        <cofactor evidence="14">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
        <text evidence="14">Contains 1 topaquinone per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>L-topaquinone</name>
            <dbReference type="ChEBI" id="CHEBI:79027"/>
        </cofactor>
        <text evidence="13">Contains 1 topaquinone per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="PTM">
        <text evidence="13 14">Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the copper/topaquinone oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.-" evidence="14"/>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PW26"/>
    <dbReference type="STRING" id="1365484.W6PW26"/>
    <dbReference type="OMA" id="CMHPSET"/>
    <dbReference type="OrthoDB" id="5379943at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008131">
        <property type="term" value="F:primary methylamine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009308">
        <property type="term" value="P:amine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.98.20:FF:000006">
        <property type="entry name" value="Amine oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.40:FF:000014">
        <property type="entry name" value="Peroxisomal primary amine oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.20">
        <property type="entry name" value="Copper amine oxidase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049948">
        <property type="entry name" value="Cu_Am_ox_TPQ-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000269">
        <property type="entry name" value="Cu_amine_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015798">
        <property type="entry name" value="Cu_amine_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036460">
        <property type="entry name" value="Cu_amine_oxidase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016182">
        <property type="entry name" value="Cu_amine_oxidase_N-reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015800">
        <property type="entry name" value="Cu_amine_oxidase_N2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015802">
        <property type="entry name" value="Cu_amine_oxidase_N3"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008559">
        <property type="entry name" value="PRK11504.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638">
        <property type="entry name" value="COPPER AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638:SF86">
        <property type="entry name" value="COPPER AMINE OXIDASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01179">
        <property type="entry name" value="Cu_amine_oxid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02727">
        <property type="entry name" value="Cu_amine_oxidN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02728">
        <property type="entry name" value="Cu_amine_oxidN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49998">
        <property type="entry name" value="Amine oxidase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54416">
        <property type="entry name" value="Amine oxidase N-terminal region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01164">
        <property type="entry name" value="COPPER_AMINE_OXID_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0186">Copper</keyword>
    <keyword evidence="10" id="KW-0464">Manganese</keyword>
    <keyword evidence="6 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12 14" id="KW-0801">TPQ</keyword>
    <feature type="domain" description="Copper amine oxidase N2-terminal" evidence="16">
        <location>
            <begin position="36"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="Copper amine oxidase N3-terminal" evidence="17">
        <location>
            <begin position="127"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="Copper amine oxidase catalytic" evidence="15">
        <location>
            <begin position="254"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="332"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via topaquinone" evidence="12">
        <location>
            <position position="416"/>
        </location>
    </feature>
    <feature type="modified residue" description="2',4',5'-topaquinone" evidence="13">
        <location>
            <position position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR600269-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR600269-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CDM27986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="698" mass="78489" checksum="74A924D55EB87589" modified="2014-04-16" version="1">MASAPDTESIPGYTIFRDGDYESVAAAAMLPKGTPHPLDQLSIKEIPEAAKIIREYANPKFVKFNCITLREPIKAEYRAFRAGAVPAPARRAFAIVFVPETNTIAEVVANLATGKVEEWKDVHDVMPTLTLEDLDVMERVARKDARVIRACNDIGITDMSKVFFDAWAIGIDERWGYDHRLQQGLAYYRNAEFDNQYAHPLDFSVVADTDTEEVLSVDIRYVNGERTAAPLKEHNYLPEYISDKYNHDRLKPIDISQPEGVSFKVRGNELSWANFKMHIGFNYREGIVISDVRTHDMYEDRERTLFNRISVVEMVVPYGCPEKPHHKKHAFDVGEYGTGLMTNSLKLGCDCKGVIHYMDGIMSTSKGEAAVVKNAICIHEEDNGLLYKHTDYRDGTVISARDRKLIVSQIITAANYEYGFYHIFTLDGTYKLEIKLTGMLNTYCMHPTETAAPFGTEVAPSINAHNHQHLFSLRIDPEIDGQNNSVVQNDAVSAEAAVGSPENPYGNGFYSKKTPLRTSLEGAADYCYETNRSWDIINPNRIHAIAKKPVAYKILNNNCPPMLAKPGSTVWKRAAFARKPLWVTPYKDYELFPAGDYVCQSDGSEGHPFNSTIADWAKRDENIENTDIVCYLQFGLTHFPRTEDFPIMPAEPVSIMLRASNFFEKNPALWVPPSAICVDTQSKNAFPSSCCAPSKPRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W6PW76</accession>
    <name>W6PW76_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g000008</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PW76"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="28"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM26199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="56" mass="6127" checksum="3B693131EE63BF0F" modified="2014-04-16" version="1">MAPSTRQQSRGNTELPENQPRSGDETETTGTEQTEPQTQGNITNPPEVTAETTRLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>W6PWS8</accession>
    <name>W6PWS8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DNA repair protein (XPGC)/yeast Rad</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PROQFM164_S01g002201</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PWS8"/>
    <dbReference type="STRING" id="1365484.W6PWS8"/>
    <dbReference type="OMA" id="LDRPGMI"/>
    <dbReference type="OrthoDB" id="2959108at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008821">
        <property type="term" value="F:crossover junction DNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd09906">
        <property type="entry name" value="H3TH_YEN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09870">
        <property type="entry name" value="PIN_YEN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000037">
        <property type="entry name" value="Rad2-like endonuclease, putative (AFU_orthologue AFUA_3G13260)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000051">
        <property type="entry name" value="Rad2-like endonuclease, putative (AFU_orthologue AFUA_3G13260)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041177">
        <property type="entry name" value="GEN1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006086">
        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006085">
        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037316">
        <property type="entry name" value="Yen1_H3TH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081:SF75">
        <property type="entry name" value="ENDONUCLEASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G13260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081">
        <property type="entry name" value="FLAP ENDONUCLEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18380">
        <property type="entry name" value="GEN1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00867">
        <property type="entry name" value="XPG_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00752">
        <property type="entry name" value="XPG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00484">
        <property type="entry name" value="XPGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00485">
        <property type="entry name" value="XPGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XPG N-terminal" evidence="5">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="XPG-I" evidence="4">
        <location>
            <begin position="111"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="407"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="480"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="607"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="725"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="826"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="488"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="736"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="751"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="785"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="797"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="843"/>
            <end position="856"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDM28390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="871" mass="96444" checksum="2FBAED203315EC41" modified="2014-04-16" version="1">MGIPGLINAIGPGERISLAKLAVTHLERTARPIRIAVDISIWLFQVQAGRGGRNPELRTLFYRLLKLLALPVHPLFVYDGRQKPAFKRGKAVSSRSYGSAPIIKRSKDLIERFRFPWHEAPGEAEAECARLQQAGIVDAVMSNDVDALMFGSSLTIMNFSKESGSGSSSATHVTCYAMGQDGHPSNIPLDRPGMILFAMLSGGDYLPSGVPKCGSKLAAEIAKAGFGEDLLQELASQADVDAGLNEWRERLQYELEENESGYFTRKHPAVRIPDAFPDRQILEYYAQPKVSGDEEMALLKTRLVQAWDKDIDPLAIRTFAADHFEWNYRSGARKLIRLLAEPLVSYRLRLQRPVLGVSPGFSFVPDCPPGLQKVYRTRSSFGTDAVPELQLDMLPADIVGLDLLAEEPNPPSEVSVQEAEEEDDPEVVAGSPPPAPSKTRITKQFDPFSLEKVWIFETVVRLGVPEVVKNWEREQAEKAAKAEEAAAKKKTGTRRTGPKKKGPIDAGMKRGSILKYGTLTKERSELSTTKQTHLLKAATSAQNPLSRLVANSGSSSPTIVDQEDDIFSSPSMYIPQRSSLTMHYVSREVDGLLDTFSSMCNLSPSANIKRHPISDQSRIRSRRTALGTGQVDIEESDALDMNTDYSPSRPTRRMGLKISYSVSDVCESETFTEDFPARALLELPSLSGKTLSKTKKIPKVQCEEKARVEHIEKAIESLSLSSKIDEENTATRSLRQPPTKKAPQAPKVRTRSSEVEDIRPPRSCSQANPKPELEPEHTLPLNLKTYENNEINEVNWSPKKSSKGTSTTPKHKTIGHLENIILHDGFWSIDPSPHEQDPCEGSATDSLSTARRQTQPAKKKRIPRVSFLDLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W6PXC7</accession>
    <name>W6PXC7_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NB-ARC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S01g002684</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OMA" id="QSWATEP"/>
    <dbReference type="OrthoDB" id="5086500at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48187">
        <property type="entry name" value="LD21810P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48187:SF2">
        <property type="entry name" value="LD21810P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NB-ARC" evidence="2">
        <location>
            <begin position="390"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="324"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="868"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="948"/>
            <end position="1090"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1136"/>
            <end position="1166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1190"/>
            <end position="1216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1316"/>
            <end position="1335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1413"/>
            <end position="1433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="325"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="868"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="885"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="904"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="961"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1030"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1079"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1137"/>
            <end position="1148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1204"/>
            <end position="1216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM28873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="1433" mass="160064" checksum="490CFF629588C547" modified="2014-04-16" version="1">MSKPRIADPEAIKVFGLTQIYTPRDHPTIDIVFVHGLNGHPHDTWTSQTTGCFWPTDLLPDVLASLCPRILTYGYNANVTAFTDGTSRDSVVSHAETLASSLAANRNLRDCSNRPIIFICHSLGGLIVKRALIYSRSLSSEKTEHLRSVYVSTFGILFLGTPHNGSDIAKWGLLLQNICNAVLPKKFIETSPQLVKALRANNETLQHINSLFADIIGRFHIYFFHETRSTDVHGTREVIVDEHSAAPYMEGVERAGIEADHSHMCKFDDDNAAGYEVVAEAILRYSRQAPAVITERWTEEKKSRIREKKAKAREIYDAKVDDTANRSMPNLNETEQSILSLPRGPATEGRNSPVSDLGNSGIFQLCAKETPLFVTPPGFHPNSTFFGMKKELEVLHSRLFKAKARPEKTMAVLISGVPGSGKTHLARQYVFTQRDCYPGGIFWIDAKSRESTYKCFWEIAQAATLIEQKVTVNPEYHETEKYVNAVRLWLQTRKDWLLIFDGVTFERDDDISKFREVLPWSKQCSIIYTSVDKTLRKKRRLYEPYCLMISRLQVGDACKLLFKDLGITRPTPEQMAKATQIVENYECLPLAIHAIGHRLNATGKPIEKYHVRSQVTDKKLAEPFLSIMNDLFRLQQKQALHLINLLSFLGHQVPVGLLNLGGAAMAAVNLEIQTSAQSGEDPDLDTTLGTLIHYGLIERISDADLFQHRSSLRHSDSDPKDVKLVSELSDSLTESSQEGFFSIYRGGSVVDVVKIHSVVQGFCRDELRIKDEENKGIMSKNDPGFFDTWLIVATRFLITSYDAAMGRMAHYEDCGLVRDYREYETHASRLLELFPKKAAINLHPLIVRETRETLRRLMKIISKEIDNVSPSSSQYSTRNQKSVFDRSSSSSSSLRDSSDEGPSRRSTFNWSDLGSSRAGTPEHIATPPPQFRLELFPPHIFRQAGYESEEGYETDGEVKTAMSQTSQATEKPNKTPPSFSPPQTAGLAEWHVVNRHSKQRSNQDTQTKRRSKGPRRFVDTKLNTPLVRLSSIQGKGSSSRTTSAETGGTLMSASEAEQALAAVRRSSNSQASADVPQPAITSPPSNKENMPTYANVATRRRLEVNQAGYAFTSPLYHDVSEDLITEPLSRSTYSEPEFNKFSHHHGADLHTTPGSQAPSRRGSVPHLEVPRNLSASVPFLFPYPPPPPYDENNSVSLPNRRKSSQLTPGSINSPGALSSIAHPSAIMPRALPSYNAKVHVGSAPERSVPEPMSRDSSAYSYQSWATEPVRYPPSFQQAEMILNPPLSMQNQQQMLTGTSWTELPLAGNAALQPDPISLSPPASSHGHLGSMEERLEHPDSGWNQEIEPVQFLHFGEHRVDVQDARLRLHESARLLHPRPHQYQPYHPNLSGPLIQHEGQIYAPASRLEAYGTRARSGSSPVQPDYAGLDVRFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W6PXD1</accession>
    <name>W6PXD1_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g002421</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PXD1"/>
    <dbReference type="OMA" id="FETRMMS"/>
    <dbReference type="OrthoDB" id="1523883at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM28610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="174" mass="19362" checksum="A926AAE65FAFF0F4" modified="2014-04-16" version="1">MGVELVAADSLALKILRVTPLIATTILLVNRLAQYFALSSFLPPYTSTKKVDHVGAALQHWLQTVVPRIWTGVIGIVLIARVALILNLFVHTEDLAGTYARLLYGIGLFFSFAHLFIAPTMLKFETRMMSPDTIPEVTLELLAGWLKINNVRIWVVDVPFWVVGVLATLESCKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W6PXP5</accession>
    <name>W6PXP5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Armadillo-type fold</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g000538</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PXP5"/>
    <dbReference type="STRING" id="1365484.W6PXP5"/>
    <dbReference type="OMA" id="NGTEHQM"/>
    <dbReference type="OrthoDB" id="26149at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040144">
        <property type="entry name" value="RAP1GDS1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10957">
        <property type="entry name" value="RAP1 GTPASE-GDP DISSOCIATION STIMULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="627"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="637"/>
            <end position="646"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM26729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="694" mass="75664" checksum="FF79E1C241715A6D" modified="2014-04-16" version="1">MSDAGISTAQLAIHGDAGHSVSKKGDLELPPIKKILSDLPEVSSSLPPRTETIGSEEQQEMFRGLREIIEKAQAVDEAGNSFDLKELHASLEEADANTKRGRRDADTLQSVNATLQKLWACNSEYLVQATEIIADGSRDPSWRAPFGQSGVLNFFLDVVSLKGEVDTRLLLHSLRVIGNSCADTDENREIVVKGNYTLAIIRYFLDPDLIFVAIPVIYNICMDYKPAHVQIAANRTAYILLKLIKDGEIEDNEALLNFSYDLIELASEQAEGIEHSPDGTIVLLMELAIDDTLDFAHFSSLVTSLAAYLENERFQNVCVSNGMVEGLLDVLRHSFSIVVDPSSNEDVKALAQLRLKINQALAEVSASPFFAQYYPLDSPLSQTLKSWVVATEDQLQVCACVMLGNLARSDEVCQVMVRDLKIHGELISVLKSDSRGAVLHSSLGFLKNLAIAGDNRAILGEAGIIPAISRLWAYESVPQVQFSAASIARQVIISSTDNISRLLAPLSQDLDSPAHQRTYLSLLLSLFEKTDSTPIKTEIGRTVASICRTVSPKARDGDDEATSLLDRLYTLHEGVSLPIGAMITQTQWPVVRSEGWFALALMATNKLGCAAVVDCLHKTEVTELLKTTLGGGTPNQDKAEETDKSQEIKDRDNAFVLVQGLLANDSGALPVGYRGMLEDLVKVNASQLKAVTDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W6PXW5</accession>
    <name>W6PXW5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g002591</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PXW5"/>
    <dbReference type="STRING" id="1365484.W6PXW5"/>
    <dbReference type="OMA" id="EKLMRMG"/>
    <dbReference type="OrthoDB" id="416496at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050508">
        <property type="entry name" value="Methyltransf_Superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42912">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42912:SF83">
        <property type="entry name" value="METHYLTRANSFERASE TYPE 11 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM28780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="333" mass="37232" checksum="2AAA52CF6965682D" modified="2014-04-16" version="1">MNVNQLRRVPLIANPQKSKPVAIKRRQPTPPRQHHPERPSSQPETPDAATAKPSHGIPPRALTFLGISALTISTYCGYLYASYTREVSKAQTLDVPRDVSDRYNTTAATFDADVELSEKATGLGKKRRDLVRQARGNVLEVSCGTGRNLPYYELGERRGLDADGHAAVLGCRSVMFVDLSPQMVAITKEKFEKLHPAFPAVFRACDAGKVEPADIGRAGKMQAPVYFDTVVQTMGLCSMPDPVATLRHLGTVTEPVRGRILLLEHGRSYYDWVNRILDNLAPSHADRHGCWWNRDIGEIVRESGLEIVEEKRWHLGTTWRYVLRPKQSEKSQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W6PXW9</accession>
    <name>W6PXW9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S01g000628</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PXW9"/>
    <dbReference type="OMA" id="YVAWERV"/>
    <dbReference type="OrthoDB" id="5401170at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM26819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="177" mass="20147" checksum="5615FEA25D60B03B" modified="2014-04-16" version="1">MSRSRGFVVTIPSINFDHLGGTEIKLDQPSLSPPRTFVIGEKISEDYQTMTQEEYERQPGPPFAVIKFSCHSLLDPTQQGFMRIYMQIPLDGTLSSVPEVRAQQAVSQCTHTELKALVSLDRENCMAVPKLLGYGEGLQGVEEFVPGGYINYVAWERVPGEPVDYYTFWKRDFEYRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W6PXX8</accession>
    <name>W6PXX8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g002437</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PXX8"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM28626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="39" mass="4220" checksum="C81789F119D25540" modified="2014-04-16" version="1">MVVCWRVVAKRSSFVPVLVGLWGTVYPALVVGFTPARTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W6PY14</accession>
    <name>W6PY14_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="7">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PROQFM164_S01g000678</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PY14"/>
    <dbReference type="STRING" id="1365484.W6PY14"/>
    <dbReference type="OMA" id="MIPAWIL"/>
    <dbReference type="OrthoDB" id="5296287at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046943">
        <property type="term" value="F:carboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17316">
        <property type="entry name" value="MFS_SV2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000395">
        <property type="entry name" value="Carboxylic acid transporter protein homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000465">
        <property type="entry name" value="Carboxylic acid transporter protein homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508:SF9">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORT PROTEIN (AFU_ORTHOLOGUE AFUA_2G09450)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="200"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="225"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="279"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="316"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="346"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="442"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="69"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM26869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="512" mass="56034" checksum="778D8F7DE7CCE48E" modified="2014-04-16" version="1">MASSNERADPIPDGMLATARQSIGDLFIWKQRVEVTNEHGESYAEWQSPEPIKNPFSLMAQLSARDWVFFLVGLAAWTADAFDFHALSIQTVKLAKYYDKSKTDITTAITLTLLLRSIGAAFFGLAGDKYGRKWPMVLNMIILGILQIATIYSKTFQQFLAVRSLFGLFMGGVYGNAISMALEHCPVNARGLMSGILQQGYSLGYVFAACANLGVGGGTDTWKTVFWIAAGISIAIGLIRICFPESQSFIEARKSGKRTMNAGEFWRETVSMLGKEWRMCIYCVILMTWFNFYSHTSQDSYTTFMLTAKELDNEGASRASILMKTGACVGGTIIGYLSQFFGRRRAIIVAALASGVLIPAWILPEGERSLSVTGFFMQFFIQGAWGVIPVHLAELSPPAFRSSFTGLTYQIGNMISSPSSQIINAVSESTFITSTTGHRVEAYGPVMAVATAIIALGIMITTAIGPEKRGRRFESVVAGVDEAADAKTMDLEAGEDKHELSSENIEMVDKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W6PYH2</accession>
    <name>W6PYH2_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peroxin 8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g000823</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PYH2"/>
    <dbReference type="STRING" id="1365484.W6PYH2"/>
    <dbReference type="OMA" id="LMVQWRQ"/>
    <dbReference type="OrthoDB" id="2357318at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055334">
        <property type="entry name" value="PEX8-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39214">
        <property type="entry name" value="MICROBODY (PEROXISOME) BIOGENESIS PROTEIN PEROXIN 8 (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39214:SF1">
        <property type="entry name" value="MICROBODY (PEROXISOME) BIOGENESIS PROTEIN PEROXIN 8 (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26001">
        <property type="entry name" value="Pex8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="666"/>
            <end position="687"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM27014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="687" mass="75176" checksum="699C55BE138BA827" modified="2014-04-16" version="1">MATERSLATLLRSLQATSSFQDAASLLPTATSFLSMLGNPLNLTLLSSQLLTAPSLWSHPVDLQSCRKILSVFNTAAIAVLQNDTTDEPRIPYGRNRKIEYEAWVKAVAEGADDKSPRWRHTLLLGGILMGFEGQNRRGLPRHIRVKLEMALVRAAQLALEELGSETGIDGQCLTMVLNYTFELLSDSERSTLDYDRLLPAMIQSSYLSSEGLDGGYFLGSIDQDVVEASGKQFRWSANSPTFAIISAVAARPLVSTLGPLSRLIAHSVDNVRDPRIVAQTVDYLAGFVRTLMVQWRQNKLSEIDVAEEAEFLDSESRDITLPALWKLLRNCLYSVVITLRAVLGRTINDPALAANSSAPYLSMQCLHILRNMYFISSRIGQNASSQQTFVMLAAIDILSQYPTLAENFLRSIKPSDIGQIPAHPIERCLDLFFLNVAEHFPLVLSPGTNEELLLSAAFPYLAAGANSLLLEIFEAAHSLVLVVFAIPHNSGLAAKHLPFYIENLFAVFPTNLSARQFRLAFKTVIQITAPPSPLANSQPALPSILLEVVHDRALNASSTPIPAQGPNPDMSLSPAVSEQAVLTLALIDSLPFLLVDDLKEWLPLAAQLINTITDRDMRHACIDRFWEAIAGGEMDVDRSYCCITWWSTEGGRELVLFGAETAPGESDDTGPYMSGAVGGVAPESKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W6PYL0</accession>
    <name>W6PYL0_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S01g002921</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PYL0"/>
    <dbReference type="STRING" id="1365484.W6PYL0"/>
    <dbReference type="OMA" id="AWHKPTC"/>
    <dbReference type="OrthoDB" id="408373at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052897">
        <property type="entry name" value="Sec-Metab_Biosynth_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37017:SF3">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37017">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="288"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="7"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM29110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="318" mass="35106" checksum="A2EA3122808E5734" modified="2014-04-16" version="1">MSTLPTLVFIPGAWHKPTCYNKVIKLLQDQHKLKCISITLPSTTGNPAATFKDDLDAAREAILSETVHGRNVVVVAHSYGGMVGNSAVKGLTQPDFTETQNQISTTGYVIGLILIASGFTLSGLAFMDPFFGHPPPSWRVNNETGYAELVTSPRELFYHDLPADEAEFWASQLTTQSLKALFEGGEYTYAGWRDVPVWYIGTVEDRGLPVVVQRINIGMAKEIGGRVEHRELQTSHSPFLSQPEMTVMIMLEAVEAFTGKLGVNQATENGLCDAIVAPRAMITQPFTWFSFGLPLVIGHILGRCILVFTWGKRFWRST</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q0S9</accession>
    <name>W6Q0S9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Amino acid/polyamine transporter I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PROQFM164_S02g000307</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q0S9"/>
    <dbReference type="STRING" id="1365484.W6Q0S9"/>
    <dbReference type="OMA" id="FIGTEAV"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000070">
        <property type="entry name" value="Amino acid transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF37">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="185"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="277"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="329"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="375"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="404"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="447"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="483"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="9">
        <location>
            <begin position="48"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDM30158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="548" mass="59649" checksum="416121A598B068DA" modified="2014-04-16" version="1">MSGVEKPLSDTKGVPSKDAEETIVGEIYEDGVDHGADSGLQRQLSSRHISMIGLASSIGMGLWLGSGTSLKNAGPAGIFLGYILSGTIIWSVSQSIGEMAIMYPLPSAFVQWTNIFVDESAGFALGWAYWFSYWITIANEVQGAITVLNFWTSAVPTAALITIFWFVIVLMNVGAVKWFAEIEVVAAAIKFGFIFVVIISGIVLSAGGGPKGGYPARPGGTIGFQFWNEMAFINGFKGFISVMPTCIFALSGSENAGLVAAETSNPLRSVPKAVKSIWVRLSLFYILGSLIVTINVSPKDENLFGASGTNSSPFVIMYRNSGVAPLAHIMNAVILVSVLSTGGISGYAGSRVLVGLAQLRMAPKVLQKTDSWGRPWWGLAPTLIIGGGLAYLNVSNGGATVFGWFSNLTSLFTLFGWGMICLSHIRMRAAWKVQGRSVEELPWKSKVFPWAAYWGLFWCVALIIIEFYLAVSPLGDKPSAENFFANYLSVVAIIILYIGAKIFYRGRRWNKLEDINLDACRRFYAPRDEEGKNEKSFAKKWLKFPTKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q1N7</accession>
    <name>W6Q1N7_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Zinc finger, LIM-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PROQFM164_S02g000602</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q1N7"/>
    <dbReference type="STRING" id="1365484.W6Q1N7"/>
    <dbReference type="OMA" id="GFERSPQ"/>
    <dbReference type="OrthoDB" id="79452at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09394">
        <property type="entry name" value="LIM1_Rga"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09395">
        <property type="entry name" value="LIM2_Rga"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00159">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.555.10:FF:000043">
        <property type="entry name" value="Rho GTPase activator Rga"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000044">
        <property type="entry name" value="Rho GTPase activator Rga"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000121">
        <property type="entry name" value="Rho GTPase activator Rga"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050729">
        <property type="entry name" value="Rho-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176:SF128">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN RGD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176">
        <property type="entry name" value="RHO/RAC/CDC GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="4" id="KW-0440">LIM domain</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="7">
        <location>
            <begin position="17"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="8">
        <location>
            <begin position="861"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="135"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="245"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="513"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="798"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="657"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="201"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="251"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="275"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="306"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="334"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="356"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="383"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="515"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="804"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="824"/>
            <end position="835"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM30453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="1067" mass="118160" checksum="99A3B8D9859CF14E" modified="2014-04-16" version="1">MENQGAYPESMEQDESYPCKGCGETLEEGKAFELAGNRWHIDCFRCSTCNTLLDSDAHLLLLGDGSLICSNCTYSCSSCNNKIEDLAILTGDQAFCAQCFRCRNCKRKIENLRYARTSQGIFCMECHESLMARRRKRKAGGSSGKKPAAPNVKLDKSLPSLPPHLLEESQINDEENSEYTGTPDPSKMAETPDLNDEGPGSSISNQQADSDNILLPSSTYRSNRQSISHNTDADADGGELLIPLAFDPSAEGNSSRGHSQTRQEPPGDYFNQASHDGREYRQEPPSRTSSDNHSPHIAYQEKGWEENNSTSPDKAPLSSSDSSKPAKGRHTRSSSDIPISFRETSNLPGPTSPDSTRSKEFSGDTKRHIPMDDFTSAGARSSNELHRHDHGSMDLPRSQPSGLPYLPKRGDSLESKLHQIPRKEVGSSPASSQYGDLPMLRSDTFEQPIQHTALNTSPHESHHYDGAGTSPVLRYGADLPMDEGLSRIIGGDDTVGQNNESFLRRVSNSVRHGRSYSEKSVRISKDLKNPRSPTTRSIAGTDVGSPITGSQSEEISWLRNELRKERLRVAELESAARTAADVKQVNTELSEKRSTMVVLDAQREIVLRELTVLTDHMEAEKRGGPSGPLDLGKLSNHVLRELAESIQKLKDSFAPQIEDLMQKRNDLSEEVEAMNIRREKSFQEFEQLSSKNAQLAELNNQLVHQIQELYKATDGQPRPNGLGISHNKQRSTTSIEVMKPPFNDYHGSTHISEESESATATVVPGPQVVSIRKGQPRKFNWKKGGQNVAKGVKGLKGAFMSSEGGQGQESGGGIPRSQTQDPSRQGFGFFGNQRGKQGGKMSQADSVPVLIEAAPDALFGTELEARQEYEKGMIPAIVTRCIQEVELRGMDMEGIYRKSGAASVIQTIREGFERSPFDYDISDPDLDIHAVTSTLKQYFRKLPNPLITYEVYELVIDSAEVNPVSARIELMQKSLLELPRVHRDVLEFLIFHLKRVVDRHEENLMTSQNVAVVFAPTIMRPESLAREMTDVQKKNDVLKFLVENCQKVFQGMQKGQGTQQGQGMQQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q383</accession>
    <name>W6Q383_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Short-chain dehydrogenase/reductase SDR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S02g001208</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q383"/>
    <dbReference type="STRING" id="1365484.W6Q383"/>
    <dbReference type="OMA" id="WVFEHED"/>
    <dbReference type="OrthoDB" id="5399006at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43431">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT CHAIN DEHYDROGENASE/REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_5G14000)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43431:SF7">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_5G14000)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM31058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="244" mass="26252" checksum="2F6F7755AD6653B3" modified="2014-04-16" version="1">MASKALAIIAGVGPGTGASIARKFAKSYSVVVLARNSENYDPVVQEINSSGGQAIGISTDVSDSKSVNAAFDKIQAQYPSSKVAAAVFNPGGGFVVKPFLELTEEDYTTALRSQALGAFNFAQRALPLLLQARESSEYPPTLIFTGATASLKGSAKFAAFASSKFALRALAQSLAREFGPQGIHVSHTVIDGIIDIPRTKAWVFEHEDAKISPDAIADSYWYLHTQPRTTFAFELDLRPYIEKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q3Y1</accession>
    <name>W6Q3Y1_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase type 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S02g000826</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q3Y1"/>
    <dbReference type="STRING" id="1365484.W6Q3Y1"/>
    <dbReference type="OrthoDB" id="66144at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43861">
        <property type="entry name" value="TRANS-ACONITATE 2-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="1">
        <location>
            <begin position="51"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM30676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="153" mass="17030" checksum="77F139E6A1E60A3C" modified="2014-04-16" version="1">MSQNAYVEPVFFVGYSKLHRSQQGLNGALEWPLLRDLVGNVQGYQVLDLGFHGIDISRNMLERAKSLTVHPAVTYSIGDLDTIELEKNLYDLVYSSLAFHYLQNLKELFGQVYDGLKAGGHFVFSVEHPIFTAPIIAPAWTESAGRTAAWAAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q4B9</accession>
    <name>W6Q4B9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="10">DnaJ protein homolog xdj1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">xdj1</name>
        <name evidence="10" type="ORF">PROQFM164_S02g001340</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q4B9"/>
    <dbReference type="STRING" id="1365484.W6Q4B9"/>
    <dbReference type="OMA" id="IVFHIVE"/>
    <dbReference type="OrthoDB" id="550424at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10747">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10719">
        <property type="entry name" value="DnaJ_zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.230.10:FF:000001">
        <property type="entry name" value="DnaJ subfamily A member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.20:FF:000013">
        <property type="entry name" value="DnaJ subfamily B member 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.230.10">
        <property type="entry name" value="Heat shock protein DnaJ, cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044713">
        <property type="entry name" value="DNJA1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001305">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43888">
        <property type="entry name" value="DNAJ-LIKE-2, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00684">
        <property type="entry name" value="DnaJ_CXXCXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="DnaJ/Hsp40 cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51188">
        <property type="entry name" value="ZF_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="J" evidence="8">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="CR-type" evidence="9">
        <location>
            <begin position="132"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CR-type" evidence="6">
        <location>
            <begin position="132"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="363"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="396"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDM31190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="412" mass="44660" checksum="58379C491F65B27D" modified="2014-04-16" version="1">MFSVAAVEVDLYALANHPDKVPESEREEASIRFKAVQEAYDILYDDDKRHLYNTHGMSAFNGSGEPGMAGQPDLDDLLAQMFGGGMGGMGGMGGMPGMGGMGGMPGGRPNKPRKSPSEEQDYEVNLEDLYKGKTVRFSSVKNVICGHCKGKGGKEKATAKKCSTCGGQGYKEVLQRMGQFVTQQTVICTTCNGEGSYFAPKDKCKKCKGTKTTEAKKILEIYIPRGARQGDRIVLEGEADQVPDQEPGDIVFKVVEEEHPVFTRAGSDLRATIEITLAESLTGFSRVVIKHLDGRGIELTHPLTAGAILSPGQVLKVPGEGMPMKRVDSRGDLYLVVDVKFPDNGWKPTSEMLEKLKEILPKPSAPIKADTVDEVEYDPKGQIEDFGAQDGQDAAGWEDEEDDDEPAQCATQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q4D7</accession>
    <name>W6Q4D7_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S02g001355</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q4D7"/>
    <dbReference type="STRING" id="1365484.W6Q4D7"/>
    <dbReference type="OMA" id="SFWWLRS"/>
    <dbReference type="OrthoDB" id="5565730at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41390">
        <property type="entry name" value="CHROMOSOME 7, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41390:SF1">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 213 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM31205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="202" mass="22112" checksum="9A4DF98EF78D51EE" modified="2014-04-16" version="1">MGDQIKDMQDFQSNALMSAAKVGALSGTAGLIYGAAAGVIRSPNPMIHSLSCGIHWFACGSAFWWLRSNIIKHHYQDKASLQERTYTSALCGGIAGGSVTKLMGGRLVPGAIIFSLLGYCGQSVFNRVDAWQMENAHKTSKPLMQRMAESKWIPLRTLSDQEYRGMLREKLLSVEAEIALLDDKIQELEQSRPASAPSPKQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q631</accession>
    <name>W6Q631_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Bifunctional polymyxin resistance protein, ArnA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S02g001896</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q631"/>
    <dbReference type="STRING" id="1365484.W6Q631"/>
    <dbReference type="OMA" id="SNTWNDS"/>
    <dbReference type="OrthoDB" id="2735536at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF562">
        <property type="entry name" value="ALDEHYDE REDUCTASE II (AFU_ORTHOLOGUE AFUA_1G11360)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="3">
        <location>
            <begin position="13"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM31745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="341" mass="37682" checksum="88199C2484465237" modified="2014-04-16" version="1">MITSYLLPADSLVLVTGANGFIASHTIDQLLAKGFRVRGTVRAPKPWLNAFFDERYGKGRFETLVMTNLGDAQELDKAMKGVSGVIHMASDLTFSSDPNAVIPWVKDSVLKVLEAASRTETIQRVVLTSSSRAAFTSLPGTTKGLTVEDNTFNDDSVKAAWDPDTPADIKPFAVYSASKTESEKAAWEWMKDNKPHFDFNTVLPDFNTGKVLHPEIGGSTMGYVRKLLKGDSSPFETFPPQWYVDVEDTARLHVIALLSHEVKSERLFAFAESKNWTDHVEALSKLRPDNKLIPKPPVNEARDEANVVPAKRAESLLQSFYGRPGWTPFHESLAAGIEGLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q648</accession>
    <name>W6Q648_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">26S proteasome regulatory subunit 7 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">RPT1</name>
        <name evidence="14" type="ORF">PROQFM164_S02g002334</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q648"/>
    <dbReference type="STRING" id="1365484.W6Q648"/>
    <dbReference type="OMA" id="RSKYHIE"/>
    <dbReference type="OrthoDB" id="1937997at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19502">
        <property type="entry name" value="RecA-like_PAN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000005">
        <property type="entry name" value="26S protease regulatory subunit 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000037">
        <property type="entry name" value="26S protease regulatory subunit 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000027">
        <property type="entry name" value="26S protease regulatory subunit 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048723">
        <property type="entry name" value="OB_PRS7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21236">
        <property type="entry name" value="OB_PRS7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-0647">Proteasome</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="13">
        <location>
            <begin position="214"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="8"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00067449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDM32183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="439" mass="48991" checksum="082D66154786EDCF" modified="2014-04-16" version="1">MPSATGENWEKFKKNYADDEEPEKKITPLTDDDIAVLKTYGAAPYANALKKLEKDIKEKQNSVNEKIGVKESDTGLAPPHLWDVAADRQRMAEEQPLQVARCTKIIQDEKDSDKSKYVINVKQIAKFVVNLGERVSPTDIEEGMRVGVDRNKYQIMLPLPPKIDPSVTMMTVEDKPDVTYGDVGGCKEQIEKLREVVEMPLLSPERFVNLGIDPPKGALLYGPPGTGKTLCARAVANRTDATFIRVIGSELVQKYVGEGARMVRELFEMARTKKACIIFFDEIDAVGGARFDDGAGGDNEVQRTMLELITQLDGFDSRGNIKVMFATNRPSTLDPALMRPGRIDRKIEFSLPDVEGRANILRIHAKSMSVERDIRWELISRLCPNATGAELRSVATEAGMFAIRARRKVATEKDFLASVEKVIKGNLKFNSTATYMQYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q6E2</accession>
    <name>W6Q6E2_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DJ-1 domain, InhA-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S02g002051</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q6E2"/>
    <dbReference type="STRING" id="1365484.W6Q6E2"/>
    <dbReference type="OMA" id="YRWIQDG"/>
    <dbReference type="OrthoDB" id="543156at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052158">
        <property type="entry name" value="INH-QAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43130">
        <property type="entry name" value="ARAC-FAMILY TRANSCRIPTIONAL REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43130:SF7">
        <property type="entry name" value="DJ-1_PFPI DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004879389" evidence="2">
        <location>
            <begin position="22"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="DJ-1/PfpI" evidence="3">
        <location>
            <begin position="56"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM31900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="252" mass="27433" checksum="73362D0A1502C7FF" modified="2014-04-16" version="1">MPPSPSTLLHIGILLLETTQLLDLSAIDLLYMTTPEYLTTCTPPLPQSLISMSRPCKMHYITANAANPTHTTSQLSIQPTSSLTSPAVAPGTLDLVLIPGPSPKTMPPANEYLDFVRAHFEAGVLVLAVCTAAFVVGYAGVADGRRVTAPRLLVPEMRRMFPGADWDERVRVVRDGNLWTCGGITNGHDLVIAYLRDHYPALLVNTILAAADITPRPVAYATSATEDTDTVYVVWRVIKAFSKAVVWFFSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q6F6</accession>
    <name>W6Q6F6_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">phosphoserine phosphatase</fullName>
            <ecNumber evidence="4">3.1.3.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">O-phosphoserine phosphohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PROQFM164_S02g002071</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM164</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HAD-like hydrolase superfamily. SerB family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.3" evidence="4"/>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q6F6"/>
    <dbReference type="STRING" id="1365484.W6Q6F6"/>
    <dbReference type="OMA" id="EWNVDVI"/>
    <dbReference type="OrthoDB" id="27226at2759"/>
    <dbReference type="UniPathway" id="UPA00135">
        <property type="reaction ID" value="UER00198"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036424">
        <property type="term" value="F:L-phosphoserine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006564">
        <property type="term" value="P:L-serine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07500">
        <property type="entry name" value="HAD_PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000143">
        <property type="entry name" value="Phosphoserine phosphatase serb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050582">
        <property type="entry name" value="HAD-like_SerB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004469">
        <property type="entry name" value="PSP"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01488">
        <property type="entry name" value="HAD-SF-IB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00338">
        <property type="entry name" value="serB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43344">
        <property type="entry name" value="PHOSPHOSERINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43344:SF2">
        <property type="entry name" value="PHOSPHOSERINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12710">
        <property type="entry name" value="HAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01137">
        <property type="entry name" value="C1.6.1:_Phosphoserine_Phosphat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01136">
        <property type="entry name" value="C1.6:_Phosphoserine_Phosphatas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00029">
        <property type="entry name" value="phosphoserine_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0718">Serine biosynthesis</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="102"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="7"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="11">
        <location>
            <position position="248"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR604469-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDM31920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="466" mass="51807" checksum="977DBE35E6DF0EB9" modified="2014-04-16" version="1">MADSTRTRPSLGQMRSSSFLQDHQQYKPMAPITPISQTIGEVLANQVNDRLILSSNPIKPDPDRVTDSGIIHSIFNHQENPLPTGTSQIVATIYYKSNHPIHPHYHPDLGPQNSPGDKIPAPEVPKGSAPTQDMDKFPREPPALEPEPLDHLYGPYVSQLCLTNFLQILETLPTPYQRMNTSHRCLDRDEHPRVVEVTFSPPPNPDYLSFPDLRKHESIWRFEREWNVEVVLQKETVFRRHKRLAVFDMDSTLIENECIDEIAKFIGVEKEVSAITERAMNGELDFTASLKERVSLLNGVSADVFEKLKSILTIAKGARELCRALKTLGFTIAVVSGGFQPLAAWLAEQLGIDIAIANHLEIDEATQTLTGKLVPSYPIVDAEHKRSLLKSIAAEHGIPLSQTLAVGDGANDLLMLHTAGLGVAWRAKSKVQLEAPVRINGESLVDILYLLGMDNEDIAELTSDVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q6H4</accession>
    <name>W6Q6H4_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphoribosylaminoimidazole-succinocarboxamide synthase</fullName>
            <ecNumber evidence="3">6.3.2.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">SAICAR synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">ADE1</name>
        <name evidence="12" type="ORF">PROQFM164_S02g002444</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM164</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SAICAR synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.6" evidence="3"/>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q6H4"/>
    <dbReference type="STRING" id="1365484.W6Q6H4"/>
    <dbReference type="OMA" id="CEPFKVE"/>
    <dbReference type="OrthoDB" id="9991235at2759"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00131"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004639">
        <property type="term" value="F:phosphoribosylaminoimidazolesuccinocarboxamide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01414">
        <property type="entry name" value="SAICAR_synt_Sc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000392">
        <property type="entry name" value="Phosphoribosylaminoimidazole-succinocarboxamide synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000015">
        <property type="entry name" value="Phosphoribosylaminoimidazole-succinocarboxamide synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00137">
        <property type="entry name" value="SAICAR_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028923">
        <property type="entry name" value="SAICAR_synt/ADE2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001636">
        <property type="entry name" value="SAICAR_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018236">
        <property type="entry name" value="SAICAR_synthetase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010568">
        <property type="entry name" value="PRK13961.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00081">
        <property type="entry name" value="purC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43700">
        <property type="entry name" value="PHOSPHORIBOSYLAMINOIMIDAZOLE-SUCCINOCARBOXAMIDE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43700:SF1">
        <property type="entry name" value="PHOSPHORIBOSYLAMINOIMIDAZOLE-SUCCINOCARBOXAMIDE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01259">
        <property type="entry name" value="SAICAR_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01057">
        <property type="entry name" value="SAICAR_SYNTHETASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01058">
        <property type="entry name" value="SAICAR_SYNTHETASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAICAR synthetase/ADE2 N-terminal" evidence="11">
        <location>
            <begin position="17"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDM32293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="301" mass="33294" checksum="080D3F2957216D56" modified="2014-04-16" version="1">MAQALTTIDLQGALPLVASGKVRDLYEIDDKTLLFVASDRISAYDVIMENGIPNKGVLLTLCTQTWFKALKEANPSLRTHFITLDLPPQIPESLRPVLQNRSMQVRKLRILPIEAIVRGYITGSAWNEYKKSGTVHGIQVPAGLQESQAFPDGPIYTPSTKAEQGEHDENIHPDQAVAILGEPYASTVAKMAVELYKTAHEYALARGVIIADTKFEFGVDEETGEVVLADEVLTPDSSRFWPKESYAVGRGQASFDKQFLRDWLVSEGLKGKEGVRIPDDIALKTAEKYHEAWEKLTGGKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q6Y5</accession>
    <name>W6Q6Y5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S02g002629</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q6Y5"/>
    <dbReference type="STRING" id="1365484.W6Q6Y5"/>
    <dbReference type="OrthoDB" id="4526299at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM32478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="85" mass="9559" checksum="1AAA7575439AB925" modified="2014-04-16" version="1">MFVNPLVTGRIMSRTSIALSTPSRHFSVTPKIYQGITLLQDKQNGFGFVRSNPRPAKPRTKGVTEIRGPYYSVMGKRYLADILET</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q8A0</accession>
    <name>W6Q8A0_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Thioredoxin-like fold</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S02g003084</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q8A0"/>
    <dbReference type="OrthoDB" id="4361376at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM32933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="101" mass="11596" checksum="C4F6F4F41A3AD8CA" modified="2014-04-16" version="1">MPVQILQDPGEVFEAIQKSPKSVVVHYWAPWMELESQFMSMFFEADENRGEEVDFVIVDSGFIHPQHSPDEMPLTVLYQGGDEVDLAPFDLEEIRALIERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q8A9</accession>
    <name>W6Q8A9_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S02g000623</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q8A9"/>
    <dbReference type="STRING" id="1365484.W6Q8A9"/>
    <dbReference type="OMA" id="WIDLIPM"/>
    <dbReference type="OrthoDB" id="2245989at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021833">
        <property type="entry name" value="DUF3425"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38116:SF1">
        <property type="entry name" value="BZIP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38116">
        <property type="entry name" value="CHROMOSOME 7, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11905">
        <property type="entry name" value="DUF3425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM30474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="285" mass="32717" checksum="E32591BA97999442" modified="2014-04-16" version="1">MTLQIDQPPLEQISSEDSMDMLDPLARRRLQNRLNQRASRKRKALEYKEKSNTAERKWVLYIDDSNISKKNASTEEGTSYQVTQSSPPRQTEVSFCSLSPAQHAALMNKFRAKALHMIENPTLLRNPTFSITQYNILRAMFINADLMGLTLELLNEDLASQFNLTGPLMSALHLPASLCPSQKQKKIIHHPWIDLIPMVSLREAILTRADVIDEDELCGDFYGSSPSQEVGLRVWGEAWDPSAYEISETLIRKFSWMVKDCPDIIKSSNHWRKQRGEKPIRFKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q8N1</accession>
    <name>W6Q8N1_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Vacuolar ATPase assembly protein VMA22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S02g002477</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q8N1"/>
    <dbReference type="STRING" id="1365484.W6Q8N1"/>
    <dbReference type="OMA" id="GQDCYDE"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990871">
        <property type="term" value="C:Vma12-Vma22 assembly complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070072">
        <property type="term" value="P:vacuolar proton-transporting V-type ATPase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040357">
        <property type="entry name" value="Vma22/CCDC115"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31996">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31996:SF2">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21730">
        <property type="entry name" value="Vma22_CCDC115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="94"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="100"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="158"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="176"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00093634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM32326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="253" mass="27765" checksum="0B408BA6569BD800" modified="2014-04-16" version="1">MAQIPTPPASRPGSEAPEVQVKPVALEDSVQCLDTLLEKYLHLLDRQQKLQSSLAGHLSSGFFALAQANFSSPPGRRYGPDYYDGRMKATRKISIQSEQDTEKPTNDPQEKGDITVPPEPGYTFSIKSTTSDPLEEADGDNETKASSPVQSGHEETSPAETASSEPSDTAETEITPVEKPERAPKKFRSTDPIHWYGILVPQSLRRAQDSFANAIDNQVPDLASTTVEMRALEQQISELRARLEIESPDATML</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q9H4</accession>
    <name>W6Q9H4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Oligopeptide transporter OPT superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PROQFM164_S02g003425</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM33273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q9H4"/>
    <dbReference type="STRING" id="1365484.W6Q9H4"/>
    <dbReference type="OrthoDB" id="77405at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015366">
        <property type="entry name" value="S53_propep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045035">
        <property type="entry name" value="YSL-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31645:SF3">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31645">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER YGL114W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09286">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="243"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="273"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S53 activation" evidence="8">
        <location>
            <begin position="2"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF09286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM33273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="344" mass="37059" checksum="F68200EF76AD9B62" modified="2014-04-16" version="1">MPVSCLEQLLQTEYWVFEQPGSGIRAIRSHEWSLPADLMDVVDVITPTNVFIHPTVQFRLGAPTPIWEEESHLPMYQDLIDEDLLDRGRLEILTQEELSANPTGDWCHRATHGAVSGDVSLYQRLNLLGGALANIGANKACELMGDFRVGFLLQTPPRLQYFAQLIGTLFATIVAPVIFKLFTTAYPCIIAEGANGNSTDAAAAQGRRCEFSGPSIATWRAVAVATTSGASGQSAIPEASGRFAVLFAAVGVMIVLLRNMLRAFPAKVYLPNMMMMGLAFTMPSPPYGIAMLMGALGARMWKWREERTFETYSSSVAAGLVAGEGIGGIVNGVLTIAVGWGGDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q9X3</accession>
    <name>W6Q9X3_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Very long-chain fatty acid transport protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">Very-long-chain acyl-CoA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">PROQFM164_S03g000182</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Acyl-CoA synthetase required for both the import of long chain fatty acids (LCFAs) (C14-C18) and the activation very long chain fatty acids (VLCFAs) (C20-C26) by esterification of the fatty acids into metabolically active CoA-thioesters for subsequent degradation or incorporation into phospholipids. The transport and fatty acyl-CoA synthetase activities are genetically separable and are thus independent activities. Esterifies VLCFAs in the peroxisome matrix. The VLCFAs are actively transported into peroxisomes by a PXA1-PXA2 heterodimeric transporter in the peroxisomal membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a very long-chain fatty acid + ATP + CoA = a very long-chain fatty acyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:54536"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58950"/>
            <dbReference type="ChEBI" id="CHEBI:138261"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Lipid droplet</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Peroxisome membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q9X3"/>
    <dbReference type="STRING" id="1365484.W6Q9X3"/>
    <dbReference type="OMA" id="VWRQFLD"/>
    <dbReference type="OrthoDB" id="10253869at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005324">
        <property type="term" value="F:long-chain fatty acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044539">
        <property type="term" value="P:long-chain fatty acid import into cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000002">
        <property type="entry name" value="Long-chain fatty acid transport protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000019">
        <property type="entry name" value="Long-chain fatty acid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43107:SF15">
        <property type="entry name" value="FATTY ACID TRANSPORT PROTEIN 3, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43107">
        <property type="entry name" value="LONG-CHAIN FATTY ACID TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 22" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-0551">Lipid droplet</keyword>
    <keyword evidence="13" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="14 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 20" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="273"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="21">
        <location>
            <begin position="74"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00051585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00060276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00068795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00078285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="CDM33458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="656" mass="73013" checksum="C4E7030A1A2A7E4A" modified="2014-04-16" version="1">MPLPSLSDIPLSLALPAAATTLAYLNARWSVSYDLNLLRGLLKMSAKSRIAERGDRLNLFYTLEAYALDPKTAGNDFIVYNGRTTTFHEGYIMVLRYGAWFKKVHGIKRKEIVAIDFMNSSTFIFMLLGLWSIGAVPAFINYNLSGKPLTHSIRTSTARLLVVDEEVRHCFPAEQEQILTSPTFRDGKGPVEIVFHTPEVEAQILGMEPTREDDKARSGLIPRDMAILIYTSGTTGLPKPAIVSWKKCWSGSLFVKDWLSITSSDRFFTCMPLYHSSASILGFITCLMSGSAMIVGRRFSARNFIKEARENDATIIQYVGETLRYLLGVAPAIDPVTGEDLDKKHNIRLAFGNGLRPDIWNRFKERFNIPTIAEFYAATEGTTGSWNLSTNDFSAGAIGRNGALGDIVLGRGSAIVEVDHETEEPWRDPKTGLCKNVPRGDPGELLFILNAADPTANFQGYFGNKKATEGKIIRDVLKKGDAYFRTGDMVRWDKEGRWFFSDRLGDTFRWKSENVSTSEVSEVLGAHPDVHEANVYGVTLPNHDGRAGCAAILFNQQVASGNLSDTALEPSREVLDTLAAHILKNLPRFAAPLFLRVTPLTQSTGNNKQQKHVLRTEGVDPALVSKKDRLYWLQGDTYVPFGQRDWERLTGGQVRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W6QA89</accession>
    <name>W6QA89_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Nuclear control of ATP synthase 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PROQFM164_S01g000511</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QA89"/>
    <dbReference type="STRING" id="1365484.W6QA89"/>
    <dbReference type="OMA" id="YHEFHED"/>
    <dbReference type="OrthoDB" id="413313at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013946">
        <property type="entry name" value="NCA2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28234">
        <property type="entry name" value="NUCLEAR CONTROL OF ATPASE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28234:SF1">
        <property type="entry name" value="NUCLEAR CONTROL OF ATPASE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08637">
        <property type="entry name" value="NCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="511"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM26702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="634" mass="71458" checksum="4E55C3577BAC9831" modified="2014-04-16" version="1">MSVIQETVCGVNTQLDRLQQQISSPQRLEATDISIESLESIGQLQDLINSISVTSKTQSLLHPSRLADLLSGTFSRLQVQTTLHEENSAQLSDHVWIAAAKAAVQASGLVMNSLLDQTLQLHDETYYWGEMLGSIWYSGLYTVQTSPGQFYRWTKDACVAQMYQEAPSITASWFRFYQIARQSAWKLGGHSIRAHLLSPIRSSRAEMRQKRDLLLKMKDLHTSSLGLLMEGWHLFEASDSATLNPGTINPQWRTAVHRAVALIEAIYRHIALEPSTHELEQGVFATLERDIDVTKIHTQGDNSVHEPLDLIERLVHVLREELPNHTTSMSLFIHRHGRPSCIVRYWLPVSAALLSGSASMRFLANRQEEIIQWIVDIGSTTVDFWGNWVVHPVRKLIGTIRHDEKSEIAIMSKNSLLADRASLERMVVDFVRDRPDLYQGVVADTTTIINSVKEGDLTPVLKAYERDLRSPFVGTVRGDLVRALLIQIQKTKVDVEIAISGIDALLKSQELVFGFVGLTPGILVSFATMRWLGGLLGSRRGLRKGKQRHELRRGLRNVARILTSSAVLSNGTVAYKDAGQLICEAEALLQHVKMISGSMQYEEFREDIQDLLNVQNGVDKQLRVIERMRWAYFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W6QAG8</accession>
    <name>W6QAG8_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Methylenetetrahydrofolate dehydrogenase [NAD(+)]</fullName>
            <ecNumber evidence="12">1.5.1.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">mtd1</name>
        <name evidence="16" type="ORF">PROQFM164_S02g003177</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes oxidation of cytoplasmic one-carbon units for purine biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.15" evidence="12"/>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM33026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QAG8"/>
    <dbReference type="STRING" id="1365484.W6QAG8"/>
    <dbReference type="OMA" id="CKVITAE"/>
    <dbReference type="OrthoDB" id="41403at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004487">
        <property type="term" value="F:methylenetetrahydrofolate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004488">
        <property type="term" value="F:methylenetetrahydrofolate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009113">
        <property type="term" value="P:purine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000255">
        <property type="entry name" value="Methylenetetrahydrofolate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10860:FF:000012">
        <property type="entry name" value="Methylenetetrahydrofolate dehydrogenase [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10860">
        <property type="entry name" value="Leucine Dehydrogenase, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000672">
        <property type="entry name" value="THF_DH/CycHdrlase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020630">
        <property type="entry name" value="THF_DH/CycHdrlase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020631">
        <property type="entry name" value="THF_DH/CycHdrlase_NAD-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48099">
        <property type="entry name" value="C-1-TETRAHYDROFOLATE SYNTHASE, CYTOPLASMIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48099:SF3">
        <property type="entry name" value="METHYLENETETRAHYDROFOLATE DEHYDROGENASE [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00763">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02882">
        <property type="entry name" value="THF_DHG_CYH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00085">
        <property type="entry name" value="THFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic" evidence="14">
        <location>
            <begin position="17"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding" evidence="15">
        <location>
            <begin position="151"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00053076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00061364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00066980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00074830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CDM33026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="334" mass="37312" checksum="07D3AA3F2FE37C2B" modified="2014-04-16" version="1">MSAPTDKPPSSCKVMLSKNVANHLLTEVHEGLKTLEKPPHLVGLLANNDPAALMYAQMTQKTCEENGFKYTMREVSRDDIEQAILNANTDNDVDGIIVYYPIFGTRQDQYLQQIVDVTKDVEGLSHRYIFNMYQNIRFLDGEAKRQKSILPCTPLANIKILEYLNIYNTILPYGNRLFGHTICVVNRSEVVGRPLAALLANDGACVYSVDITGVQKFTRGEGLQKNTHEVVDLEGKTLKDVVPLCDVVITGVPSEKYKFDTSLLREGAVCVNFSSEKNFPYEVRDKASLFVPSIGKVTIVVLLRNLLRLIQNKRMDDVKPAEATERPGTLEASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W6QAJ1</accession>
    <name>W6QAJ1_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosomal protein S2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PROQFM164_S03g000422</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS2 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QAJ1"/>
    <dbReference type="STRING" id="1365484.W6QAJ1"/>
    <dbReference type="OMA" id="PYIFMEK"/>
    <dbReference type="OrthoDB" id="2320368at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01425">
        <property type="entry name" value="RPS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10490:FF:000061">
        <property type="entry name" value="40S ribosomal protein S2, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10490">
        <property type="entry name" value="Glucose-6-phosphate isomerase like protein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00291_B">
        <property type="entry name" value="Ribosomal_uS2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001865">
        <property type="entry name" value="Ribosomal_uS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005706">
        <property type="entry name" value="Ribosomal_uS2_bac/mit/plastid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018130">
        <property type="entry name" value="Ribosomal_uS2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023591">
        <property type="entry name" value="Ribosomal_uS2_flav_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01011">
        <property type="entry name" value="rpsB_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12534">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S2 PROKARYOTIC AND ORGANELLAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12534:SF0">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00318">
        <property type="entry name" value="Ribosomal_S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00395">
        <property type="entry name" value="RIBOSOMALS2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52313">
        <property type="entry name" value="Ribosomal protein S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00962">
        <property type="entry name" value="RIBOSOMAL_S2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="15"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="18"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="52"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDM33698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="341" mass="37467" checksum="44F87B9473D645A8" modified="2014-04-16" version="1">MRQGRQLLALSRRAPISSRFQSTLPETPVETLQTSIRDEISRPENPLFEMVQAQSEASTPAQQEFTSDEPQRSNFKKLGTSVKSSYDPENIIRNPPKPSQISLEMLLAAGTHLGHSTSRWNPQNSRYIFGIREGVHIISLDVTAAHLRRAAKVVEEVAARGGLILFAGTRKGQKRAVVKAASLAKGYHIFERWIPGSLTNGEQILGHCETKVVNALDEELPRFKSDLADRPSLKPDLVICLNPLENVVLLHECGLNNVPTIGVIDTDADPTRVTYPIPSNDDSLRATCLIAGILGRAGEAGQLRRLKMAREGRTSYNPITAEELRLDPFTGQAPGGEGQKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W6QBW3</accession>
    <name>W6QBW3_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="7">GPR1/FUN34/yaaH</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PROQFM164_S02g001790</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QBW3"/>
    <dbReference type="STRING" id="1365484.W6QBW3"/>
    <dbReference type="OMA" id="PPNKVKG"/>
    <dbReference type="OrthoDB" id="3648309at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015123">
        <property type="term" value="F:acetate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051633">
        <property type="entry name" value="AceTr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000791">
        <property type="entry name" value="Gpr1/Fun34/SatP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31123">
        <property type="entry name" value="ACCUMULATION OF DYADS PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31123:SF4">
        <property type="entry name" value="PROTEIN ALCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01184">
        <property type="entry name" value="Gpr1_Fun34_YaaH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="71"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="129"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="199"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="232"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM31639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="285" mass="30781" checksum="E2ADC3B8EB3339B9" modified="2014-04-16" version="1">MAKTSDSSTSEGVNFANDVQHAENGDSSAFERTRSRGSIMLSPELFEKLYLNPKPQVAGNLRSIIGNPTPIAITGFVMALTPLSFSLMGWRGAGNNGIAHIGAYIFFGGILLLVGGLLECIIGNTFSSVVFMSFACFYLTLATTLQPFYNAYAAYSPNPDDPTAGLTSEGFNASFGFFIVCFNLLCFFYLICSFRTNFVLVYILFTVVIGVGLINAAYWYLAMQETVLAGKFQIGGGAVLFAACLGGWYLLFSLLLESVDFPLRLPVGDLSSHVPGLSQLQKKSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>W6QCA5</accession>
    <name>W6QCA5_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">pectinesterase</fullName>
            <ecNumber evidence="3">3.1.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PROQFM164_S02g001950</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Glycan metabolism; pectin degradation; 2-dehydro-3-deoxy-D-gluconate from pectin: step 1/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the pectinesterase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.11" evidence="3"/>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QCA5"/>
    <dbReference type="STRING" id="1365484.W6QCA5"/>
    <dbReference type="OMA" id="TWAQANH"/>
    <dbReference type="OrthoDB" id="3934656at2759"/>
    <dbReference type="UniPathway" id="UPA00545">
        <property type="reaction ID" value="UER00823"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030599">
        <property type="term" value="F:pectinesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042545">
        <property type="term" value="P:cell wall modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000045">
        <property type="entry name" value="Pectin methylesterase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000070">
        <property type="entry name" value="Pectinesterase_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31321">
        <property type="entry name" value="ACYL-COA THIOESTER HYDROLASE YBHC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31321:SF137">
        <property type="entry name" value="PECTIN METHYL ESTERASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01095">
        <property type="entry name" value="Pectinesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0063">Aspartyl esterase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011109163" description="pectinesterase" evidence="6">
        <location>
            <begin position="21"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="Pectinesterase catalytic" evidence="7">
        <location>
            <begin position="163"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM31799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="389" mass="41740" checksum="E56170DE580D3E54" modified="2014-04-16" version="1">MLPYILSLLCLLLHTQGATTTPIHPITRQTCQSTGHCPPGTLIVSRTPNHKNTTHPTLQSAINSLPNDNTPQTILLLAGSYIEQVNITRPGPLTLLGETSNPRDASRNRVRITWAAANSDSTGAVDNVFSSVLVVAPTLEASLTGSGPTGYPVPADTPFGNTDFRVYNVDFENTWAEYSDGPAHALSLSRANGGFYYCGFYSYQDTVYIGKLGNAYFYQSILAGQTDFLYGFGTAWIQSSALQLRGCGGGITAWKGTNTTTPNKYGVYIVDSSVRAANASVATDIQGACALGRPWNSQHRSIFACCYEDGSVDPRGYVDWVVGGVGRFEEGVTLMAEYRDFGPGVNVTGRVEGGVTSVLGLGGWEAYNTPLKVFGDVEWVDWGVVRGTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W6QCC2</accession>
    <name>W6QCC2_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Ribophorin II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PROQFM164_S03g000460</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QCC2"/>
    <dbReference type="STRING" id="1365484.W6QCC2"/>
    <dbReference type="OMA" id="VFFMYYT"/>
    <dbReference type="OrthoDB" id="432292at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056790">
        <property type="entry name" value="Ribophorin_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008814">
        <property type="entry name" value="Swp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12640:SF0">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12640">
        <property type="entry name" value="RIBOPHORIN II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25147">
        <property type="entry name" value="Ribophorin_II_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044218834" evidence="8">
        <location>
            <begin position="24"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="190"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="233"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="258"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="Ribophorin II C-terminal" evidence="9">
        <location>
            <begin position="181"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF25147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDM33736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="289" mass="30574" checksum="B02C42275312AC27" modified="2014-04-16" version="1">MHLWQATVPFCLLAAAALPGAAAAAWGFTDATVAVQSKGAGVNGGFKEKLTASKPLSKPVSLLGADTLRVTLTAQEDSSPKRADQAFLLLKDAQTGLDISYPFNIKDNGKSRVELTQKDLPIQFLSLSGPVDAHVVIGGFGSSDAYDSSVFKLSIDRNPGEAVPTVETERYGKKPEIHHIFKDSASSPPIVITLAFVAMVGAAFPALAGLWLFLGANVNHLPSAFKSAPLSHAVFLGSLISFEGIFFLYYTSWNLFKVLPAMAVVGVIAFVSGSRALGEVQGRRLAGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W6QCJ3</accession>
    <name>W6QCJ3_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Probable altered inheritance of mitochondria protein 13, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g001131</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QCJ3"/>
    <dbReference type="STRING" id="1365484.W6QCJ3"/>
    <dbReference type="OMA" id="GKSLNCW"/>
    <dbReference type="OrthoDB" id="5544375at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012471">
        <property type="entry name" value="DUF1690"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07956">
        <property type="entry name" value="DUF1690"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="84"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM27322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="219" mass="23854" checksum="CE72013B819FF66A" modified="2014-04-16" version="1">MGAGNSKPEASAGSQHVFSSNSPVQFSSNLVDALQSNSETDSTRAKVLELEIQNRVAQELQRLREREQQTLAEIEKRISESKDTTSLPVTAATAPLAPSTSGYPAGSLNLDAPRIPFAGRHHDPAPTVIAPQETAVATRPVKRDVSRNSVAAEIEQLRSKLDGRRKLVELDDGVAKARSDVTSCLQLNDRRPLNCWVEVDAFKREVARMEAAFVDRIVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W6QCV0</accession>
    <name>W6QCV0_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Velvet factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PROQFM164_S01g001243</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the velvet family. VelB subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QCV0"/>
    <dbReference type="STRING" id="1365484.W6QCV0"/>
    <dbReference type="OMA" id="YQDGRSW"/>
    <dbReference type="OrthoDB" id="1746739at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3960">
        <property type="entry name" value="Velvet domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021740">
        <property type="entry name" value="Velvet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037525">
        <property type="entry name" value="Velvet_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038491">
        <property type="entry name" value="Velvet_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33572">
        <property type="entry name" value="SPORE DEVELOPMENT REGULATOR VOSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33572:SF3">
        <property type="entry name" value="VELVET COMPLEX SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11754">
        <property type="entry name" value="Velvet"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51821">
        <property type="entry name" value="VELVET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0749">Sporulation</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Velvet" evidence="8">
        <location>
            <begin position="47"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="329"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="23"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="329"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM27432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="348" mass="37905" checksum="054CC80A0177A928" modified="2014-04-16" version="1">MYAVEDRHHPVPAPLSMDRISAPTVQYPSGSNSLRQSDHLAPVTNYQDGRSWSLQVVQQPIRARMCGFGDKDRRPITPPPCIRLIVRDAQTDKEIDINEIDTSFYVLTVDLWNADGTNEVNLVKHSATSPSISTAMSSSYPPPPQSVSPTYPGYNQNQYPVGYPPQMNNYYGGQQVAYQNQYGQPVTYPQYYSGGQMPPSMSPAAQPVSGGGGPGGMFTRNLIGSLSASAFRLTDPDNKIGVWFILQDLSVRTEGTFRLKMSFVDVGTSSAETTNGPPVINHGTAPVLASVFSEPFQVFSAKKFPGVIESTQLSKCFALQGIKIPIRKDGVKGPRRGGDGDDDDEGDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>W6QDL5</accession>
    <name>W6QDL5_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">mitochondrial processing peptidase</fullName>
            <ecNumber evidence="5">3.4.24.64</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Beta-MPP</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">pep</name>
        <name evidence="18" type="ORF">PROQFM164_S03g001505</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalytic subunit of the essential mitochondrial processing protease (MPP), which cleaves the mitochondrial sequence off newly imported precursors proteins. Preferentially, cleaves after an arginine at position P2.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of N-terminal transit peptides from precursor proteins imported into the mitochondrion, typically with Arg in position P2.</text>
            <dbReference type="EC" id="3.4.24.64"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the peptidase M16 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.64" evidence="5"/>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QDL5"/>
    <dbReference type="STRING" id="1365484.W6QDL5"/>
    <dbReference type="MEROPS" id="M16.003"/>
    <dbReference type="OMA" id="IDVVCDM"/>
    <dbReference type="OrthoDB" id="10251424at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006627">
        <property type="term" value="P:protein processing involved in protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000002">
        <property type="entry name" value="Mitochondrial-processing peptidase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000001">
        <property type="entry name" value="Mitochondrial-processing peptidase subunit beta, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050361">
        <property type="entry name" value="MPP/UQCRC_Complex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001431">
        <property type="entry name" value="Pept_M16_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851:SF149">
        <property type="entry name" value="GH01077P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851">
        <property type="entry name" value="METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00143">
        <property type="entry name" value="INSULINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M16 N-terminal" evidence="16">
        <location>
            <begin position="51"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="17">
        <location>
            <begin position="203"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CDM34778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="479" mass="53083" checksum="C0EEE9D8A0AEEA85" modified="2014-04-16" version="1">MASRRLAFNLNQALRTRAALKSIQPVKRGFASPVALPSTTQSTTLSNGFTIATDHSPWAQTSTVGVWIDAGSRAETDKTNGTAHFLEHLAFKGTNKRSQHQLELEIENMGAHLNAYTSRENTVYYAKAFNNDVPKAVDILADILQNSKLEASAIERERDVILREQEEVDKQLEEVVFDHLHATAYQAQPLGRTILGPKENIQTITRDNLTDYIKTNYTADRMVLVGAGGIPHEQLVRLAEEHFGGLPSKPPTSAALALTAEQKRIPEFIGSEVRLRDDTIPSAHIALAVEGVSWKDDDYFTALVTQAIVGNWDRAMGQSPFLGSKLSSHVSHHNLANSFMSFSTSYSDTGLWGIYLVSENLTQLDDLIHFTLREWSRLCNNVSSAEVERAKAQLKASILLSLDGTTAVAEDIGRQIITTGRRLSAEDIERTVSQITEKDVMDFATRKLWDQDLAMSAVGSIEGILDYQRIRADMSRMIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>W6QE86</accession>
    <name>W6QE86_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Zinc finger C2H2-type/integrase DNA-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PROQFM164_S03g001780</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM35053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QE86"/>
    <dbReference type="STRING" id="1365484.W6QE86"/>
    <dbReference type="OMA" id="SFQGHRR"/>
    <dbReference type="OrthoDB" id="8117402at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001227">
        <property type="term" value="F:DNA-binding transcription repressor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071277">
        <property type="term" value="P:cellular response to calcium ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000146">
        <property type="entry name" value="C2H2 type zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000181">
        <property type="entry name" value="C2H2 type zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000239">
        <property type="entry name" value="C2H2 type zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24399:SF23">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24399">
        <property type="entry name" value="ZINC FINGER AND BTB DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="532"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="560"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="30"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="194"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="293"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="384"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="707"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="156"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="202"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="298"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="444"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="468"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="731"/>
            <end position="743"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDM35053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="768" mass="83354" checksum="C8298546710548CE" modified="2014-04-16" version="1">MTSHDQNHGTAYCPEHDQNHGAVYCSEDMKHRSISPSPHGQQYHDPNPGGLGVDPSSMAAYSTNLSYQNPDGSIGGAEIYGYPNYLTGAPLTQTLSPLGGQGYAPTINTNLPISQSFETSLVNQLEHSSTGMRRMQGDENFSNMLNSNHPELDFSLYQNHSPNSASTPEYDSSLLLDPQMQQHQSINQAINPADLVSPISNPSVSSHPSQDQQHSSPGPMSPPGSTPGAYYTPRHSRHTSLDPATAAYLSAQSGPDWQSVMNNVSFQGHRRAPSEVSEVSSASHSPYLSQHEFDGIENNASPSLIPQNDPNLYDNGLGMESFTLSEQHQQGISPLHSPYISPRLMPQQGNEMVPNNSYLTQFPSAPTDMYGMPQEDMMNMGQLNNIPGDIGQASQMAPPSINVEFAPPSRAPSFGPAKSTADFDSLSPPAMRSRVRSKSDPYHPASRPRSPATSAASLGPRAPATPRSLSPVGSIGSRSSPSSRDPSPSRSNRRLSTSSIENRNYILDLADPQRPGAVPGEPKRIQKHPATFQCTLCPKRFTRAYNLRSHLRTHTDERPFVCTVCGKAFARQHDRKRHEGLHSGEKKFVCRGELSRSGQWGCGRRFARADALGRHFRSEAGRVCIKPLLDEESRERDRVLLEHQQQQQQSPSGHLQPIPQPLVMPNMPGMDGQSTGNFILPAALLAQYPALQTLQWDQISAVGDDPSDIGGRSSFDASSGGEFGFDEDDSGMGGYGNNQGGMYGVDNSGQMLGVNSGDPGYSDQKWTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W6QED4</accession>
    <name>W6QED4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S03g001110</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QED4"/>
    <dbReference type="STRING" id="1365484.W6QED4"/>
    <dbReference type="OMA" id="DAQFWES"/>
    <dbReference type="OrthoDB" id="1708389at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021709">
        <property type="entry name" value="DUF3292"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38694:SF2">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38694">
        <property type="entry name" value="CONSERVED EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11696">
        <property type="entry name" value="DUF3292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="318"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="343"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="404"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="425"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM34386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="637" mass="70292" checksum="1C2B60E044F34530" modified="2014-04-16" version="1">MSHGSQMPGQLEDESNDLTQTPPESGPLQTLSPRPPPNTQWKASSRQVEETLAKGLSNEDLWMLIRRFDKQIYHVKAVRDTAALNLDLNRTENEKFPPEKLRMTLERFYISVVVGVTEFIRHITRLRSWKEPARTTMFCTGYFVAWALDLLVPTIMGLVVALIMVPPVRLLLFPGLARADGPNGKNSKGGQVQSEDSLTGAPETHKGETAEQEAKNMVDSFATVAMESAAAKYGQTVTDDSSDGPALIESLEAVEAAAETPAGDSPEDKTKKPMKKKVSHATDNVMRMLSDITDTYEKFANILSPTPPFLLVTSRLRLAGIFTLVSVIVSFTSSYWIIKIIGFALGLGFFGDPIFTYTLDMLDRKVPNWRDQLDLNKTLLAGVPTNAQLTLTLLRIGEINSSPLPPAPSSDDNEPVWPLRRKKSQAASSTDVSRQGSSVDLPSTVSTTSLSETKVPKKKFVFRLFKFFRRTIATAIKGHIAFDRAIAIAGSAHTKNLLSMLQNGHFASTPLGPLKFDAKFERKRGAAVIDSSKEPPILYFTTYQSAGLDDLRIESRKKGSVLFQIPVTEIKELKKTEGLGWKGKLIVELTAGSKEAADGLVVSGDELGQSYHLTGMRSRNQLFNRLVAMDAQFWESR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W6QEG3</accession>
    <name>W6QEG3_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S02g002745</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QEG3"/>
    <dbReference type="STRING" id="1365484.W6QEG3"/>
    <dbReference type="OMA" id="IKVECYV"/>
    <dbReference type="OrthoDB" id="4367900at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM32594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="114" mass="12834" checksum="D20B40043268C4E8" modified="2014-04-16" version="1">MDHPTSPSPINRPAKRQCRVPVRTRGTLIAEFIKVECYVVKSAQKIRLEEEQRQLQASNDLLASDSDILLQLCNIQASVLSERKRAVQALCNDVVSAFKASDLQAYPVDEPEPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W6QEN1</accession>
    <name>W6QEN1_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Mitochondrial fission 1 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">fis1</name>
        <name evidence="14" type="ORF">PROQFM164_S03g001215</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Has a role in mitochondrial fission. Has a role in outer membrane fission but not matrix separation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="12">The C-terminus is required for mitochondrial localization, while the N-terminus is necessary for mitochondrial fission.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the FIS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QEN1"/>
    <dbReference type="STRING" id="1365484.W6QEN1"/>
    <dbReference type="OMA" id="QFNYAWG"/>
    <dbReference type="OrthoDB" id="421154at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12212">
        <property type="entry name" value="Fis1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000179">
        <property type="entry name" value="Mitochondrial fission 1 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016543">
        <property type="entry name" value="Fis1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033745">
        <property type="entry name" value="Fis1_cytosol"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028061">
        <property type="entry name" value="Fis1_TPR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028058">
        <property type="entry name" value="Fis1_TPR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13247:SF0">
        <property type="entry name" value="MITOCHONDRIAL FISSION 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13247">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 11 TPR REPEAT PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14853">
        <property type="entry name" value="Fis1_TPR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14852">
        <property type="entry name" value="Fis1_TPR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF008835">
        <property type="entry name" value="TPR_repeat_11_Fis1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 12" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR008835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDM34491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="152" mass="16742" checksum="84BE1495F46A8C65" modified="2014-04-16" version="1">MSNLPYAADAESPLKPAELQVLRAQYEKEGDYVGIQTKFNYAWGLIKSNIRSEQQEGVRLLSEIFRGAPERRRECLYYLALGNFKLGNYGEARRYNDLLLEKEPANLQAASLGSLIDDKVAKEGLVGVAIVSGLALVAGIVGSLVIKGARRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W6QES1</accession>
    <name>W6QES1_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pre-rRNA-processing protein PNO1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Pre-rRNA-processing protein pno1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">PNO1</name>
        <name evidence="12" type="ORF">PROQFM164_S03g001692</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Required for small ribosomal subunit (SSU) synthesis. Has a role in the processing of early nucleolar and late cytoplasmic pre-RNA species.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the small ribosomal subunit, ribosomal RNA processing complex (SSU RRP complex).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PNO1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QES1"/>
    <dbReference type="STRING" id="1365484.W6QES1"/>
    <dbReference type="OMA" id="TPLRNNW"/>
    <dbReference type="OrthoDB" id="1932641at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22391">
        <property type="entry name" value="KH-I_PNO1_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22392">
        <property type="entry name" value="KH-I_PNO1_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000009">
        <property type="entry name" value="RNA-binding protein PNO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000048">
        <property type="entry name" value="RNA-binding protein PNO1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055212">
        <property type="entry name" value="KH-I_PNO1_first"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055211">
        <property type="entry name" value="KH_PNO1_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12826">
        <property type="entry name" value="RIBONUCLEASE Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12826:SF13">
        <property type="entry name" value="RNA-BINDING PROTEIN PNO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22891">
        <property type="entry name" value="KH_PNO1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="11">
        <location>
            <begin position="160"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00071744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDM34965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="255" mass="28258" checksum="2C50555A614DE70A" modified="2014-04-16" version="1">MSAPTAIRQPEQALEFQPETVSHDQDDEVLIDVQAVDEGAPINPVAESAEDTEMRIDEEGRPVFTPAKDVAAAYRIETRKVPVPPHRMTPLKASWAKICPPIVEHLKLQVRMNIKTRSVELRTSKFTTDVGALQKGADFVKAFTLGFDLDDAIALLRLDDLYIQTFEIKDVKTLNGEHLGRAIGRIAGKDGKTKFAIENASRTRVVLADQKIHILGGFKNIHIAREAIVSLILGSPPGKVYGNLRTVASRMKERF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W6QF93</accession>
    <name>W6QF93_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Amidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PROQFM164_S03g001451</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the amidase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QF93"/>
    <dbReference type="STRING" id="1365484.W6QF93"/>
    <dbReference type="OMA" id="EMMKMWT"/>
    <dbReference type="OrthoDB" id="6428749at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072:SF6">
        <property type="entry name" value="AMIDASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G14530)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072">
        <property type="entry name" value="AMIDASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001221">
        <property type="entry name" value="Amidase_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="5">
        <location>
            <begin position="96"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="3">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="3">
        <location>
            <position position="227"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="3">
        <location>
            <position position="251"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="248"/>
            <end position="251"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDM34726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="585" mass="63135" checksum="A96B41586C26C4FE" modified="2014-04-16" version="1">MASQEPRYVAVAQRKQADLAAAIPAEWRLPSHLIPSGMLSISESITVGPKNYERVGVMDIPRTCGILTPKELEITEKYDVRSLVAEMTEGRLKAEDVVRGFCKRAAVAQQLTRCLTEPLFDCALQRARELDDHLQRTGTPIGPLHGLPVSVKDTFNIKGVDSSIGLSALAFKPAKANAPLVDLLQSLGAVVIAKTNVPQTLGTLDSCNHLFGRTLNPLNRKWTAGGSTGGEGALLAMRGSMVGFGTDIGGSIRVPAMCQGIYGFKPSSGRVPFGGQQSGQIEGKGRIGLQAVAGPLARSVADINAIMTEIVPRAELFGEDCIPGSWSVPAIPLAPAPRHSFTIGVLKTDGLVTPLPPITRILNEVANSLRRTPGVEVVEIPLPPVLAKCQALAGRLMGIDDGSHMLDLIESMDEDLIPWLQGRMKRGKALTVVQLATLQAQRSEIEREMMKMWTLSSQAPSVVRRVDAIICPVAPHPVPEMDRYNAVGYTSTFVLLDYPAASVPVRSFTEADLEIGREMEAPVLGSWDKANRQLWDEKTVDRRVYLGSPLSVQVVTPKQHDYQLFQAMEIVDRAVQSGGSASAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>W6QFJ4</accession>
    <name>W6QFJ4_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">General transcription and DNA repair factor IIH</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">tfh47</name>
        <name evidence="16" type="ORF">PROQFM164_S04g000459</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module TFIIK controls the initiation of transcription.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the GTF2H2 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QFJ4"/>
    <dbReference type="STRING" id="1365484.W6QFJ4"/>
    <dbReference type="OMA" id="INWVEVP"/>
    <dbReference type="OrthoDB" id="284275at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000439">
        <property type="term" value="C:transcription factor TFIIH core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01453">
        <property type="entry name" value="vWA_transcription_factor_IIH_type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000477">
        <property type="entry name" value="General transcription and DNA repair factor IIH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000015">
        <property type="entry name" value="General transcription factor IIH subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007198">
        <property type="entry name" value="Ssl1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004595">
        <property type="entry name" value="TFIIH_C1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012170">
        <property type="entry name" value="TFIIH_SSL1/p44"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00622">
        <property type="entry name" value="ssl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12695">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12695:SF2">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07975">
        <property type="entry name" value="C1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04056">
        <property type="entry name" value="Ssl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015919">
        <property type="entry name" value="TFIIH_SSL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01047">
        <property type="entry name" value="C1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="8 12" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7 12" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="VWFA" evidence="15">
        <location>
            <begin position="86"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="13">
        <location>
            <begin position="311"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="427"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="427"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR015919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR015919-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CDM35578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="447" mass="49380" checksum="6A3AF560F9569DD8" modified="2014-04-16" version="1">MADSDEEYVGEVTEDEDDLQVTRGDNPRAKRKQRGGAEWELSRTWETLVEGADGTINSTVEGLLEAGKRKRLLKDTTPLQRGIIRHLILILDLSQSMSEKDLRPTRYLLTLRYAQEFVREFFEQNPISQLGVLGLRDGLALRVSDMSGNPTEHLTAIQALKTQDPKGLPSLQNGLEMARGALFHTPSHGTREVLFIYGSLLSSDPGDIHQTIDTLISDKIRVNMVGLAAQVAICRELCTKTNGGDETAYGVALNEQHFRELMMDVTTPPAAYSQKESAGSLLMMGFPSRTVESYPSLCACHSKPSRGGYLCSRCNSKVCSLPAECPSCGLTLILSTHLARSYHHLFPLINWVEVPWRRASRSSACFACGLSFPSVPLEDHWQMTENQTKGMSVSSRYECTACHNHFCIDCDLFAHEVVHNCPGCQSKSTSLHSEAPNPTSGGMDIMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>W6QFX5</accession>
    <name>W6QFX5_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Palmitoyltransferase PFA4</fullName>
            <ecNumber evidence="11">2.3.1.225</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Protein S-acyltransferase</fullName>
            <shortName evidence="11">PAT</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Protein fatty acyltransferase 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">pfa4</name>
        <name evidence="11" type="synonym">PFA4</name>
        <name evidence="15" type="ORF">PROQFM164_S02g003245</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Mediates the reversible addition of palmitate to target proteins, thereby regulating their membrane association and biological function.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11 12">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Endoplasmic reticulum membrane</location>
            <topology evidence="11">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="11 12">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the DHHC palmitoyltransferase family. PFA4 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="11"/>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM33094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QFX5"/>
    <dbReference type="STRING" id="1365484.W6QFX5"/>
    <dbReference type="OMA" id="WEIERHK"/>
    <dbReference type="OrthoDB" id="331948at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03199">
        <property type="entry name" value="DHHC_PAT_PFA4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033682">
        <property type="entry name" value="PFA4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12246">
        <property type="entry name" value="PALMITOYLTRANSFERASE ZDHHC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11 12" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 11" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6 11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0564">Palmitate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 11 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11 12">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11 12">
        <location>
            <begin position="44"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11 12">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11 12">
        <location>
            <begin position="178"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="14">
        <location>
            <begin position="89"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="294"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="342"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="352"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="387"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="active site" description="S-palmitoyl cysteine intermediate" evidence="11">
        <location>
            <position position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CDM33094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="430" mass="49677" checksum="1D52440D171636A8" modified="2014-04-16" version="1">MLGEDFSITKLAIPAVSVLIAFLAYTSQYLFLHFESAPLKRDEIWNINIFALCIWICYYRTCFVDPGRLPKAEERPKPKEQEGEALASRQRWCRRCEAYKPPRAHHCKTCKRCIPKMDHHCPWTSNCVSHFTIPHFMRFLFYATVGMSYLETLLWQRASFVWKNSHLPSYLGPTLGQLIHLFILLVVNSFTTFALFVLLLRSLWAIGSNTTTIETWEIERHATLVRRARVLGGYLEGPGGIRVHIKKQEYPYDIGIWANIKQSMGGSANVISWFWPLAASPDRRSGWEFETNDFEDPGVSWPPPDPDRIPVPVSTRSDNISMPAYASIQDEIDAFNRRKQEDMKRFQSPGVQRRKPFHDRYKKGAYAESDSDESGTDSGGYSEEGEESWRNAEGERLRDFGVDEEAEFYDEEDIPLGVLIERRKRQQSAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W6QG37</accession>
    <name>W6QG37_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein HGH1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PROQFM164_S03g001663</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HGH1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QG37"/>
    <dbReference type="STRING" id="1365484.W6QG37"/>
    <dbReference type="OMA" id="MCILLTN"/>
    <dbReference type="OrthoDB" id="9986677at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039717">
        <property type="entry name" value="Hgh1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007206">
        <property type="entry name" value="Protein_HGH1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007205">
        <property type="entry name" value="Protein_HGH1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13387">
        <property type="entry name" value="PROTEIN HGH1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13387:SF9">
        <property type="entry name" value="PROTEIN HGH1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04063">
        <property type="entry name" value="DUF383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04064">
        <property type="entry name" value="DUF384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein HGH1 N-terminal" evidence="4">
        <location>
            <begin position="94"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="Protein HGH1 C-terminal" evidence="5">
        <location>
            <begin position="283"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="332"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="332"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDM34936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="364" mass="41104" checksum="3AC7D75AB12A87FA" modified="2014-04-16" version="1">MPTELEDLVEFLHHGNTPIRQISCETLVGFSTTQPEVFKRNQLLPVRDLMLLVRDYDPIAKNALTILVNLSGDEEVLKLLAGDDKFIEELLTKLTNPKEPNADEVAMLLANLVKSENLNKLFALKRKVPESVSTSENAIDQVMDCFVKGAEGGLNKNANYDYLSYVFADLSQTEQGRAYFTQRQEYDGVVPITKLTVFTEHRSDIRRKGVASTIKNVAFEIDSHPMLFDEDGANLLPYLLLPLAGPEELAEDDTADMLPDLQLLPPDKQRDSDPTIITTHLETLLLLTTTRDGREKMRAVKVYPLIRETHMHVEDENVTEACDRLVQVLMRDEAKEGEGEGEKEPEQPQIEAPQNEDEKVVELF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W6QGA8</accession>
    <name>W6QGA8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S03</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S03g001733</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM35006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QGA8"/>
    <dbReference type="STRING" id="1365484.W6QGA8"/>
    <dbReference type="OMA" id="MTARICN"/>
    <dbReference type="OrthoDB" id="2956246at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="215"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM35006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="297" mass="32920" checksum="AB22B1B7FDA952A3" modified="2014-04-16" version="1">MDCYHWYFIPRGYPFLAPGMHKHSSAPSLSGGELPPTGALTSGYVFRIENEATVHFLQSVGKTGNLLNLVVDLPPTTIKEKLRCLIESPGKTLLFLYAIGQILTVAVIIILALLEDWWALVTLAMWMTARICNTWSIKIRSHIDWKGETEPGVNGDLLILLTQDRWIRLRGTVDDLKAVTSGQWLRDKTLLDELLITFSTLMVYLSAVISGNSSIMGSLCLLCLMLVSAGLLELCTGLSKGFRMYGRMLKVVGKPTPYTRRLDLAEELIQETGRDDWAIGLGMILKPTGRGEGPVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W6QGL4</accession>
    <name>W6QGL4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S03g001843</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM35116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QGL4"/>
    <dbReference type="OMA" id="DACCPSH"/>
    <dbReference type="OrthoDB" id="4367081at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1170.10">
        <property type="entry name" value="Inhibitor Of Apoptosis Protein (2mihbC-IAP-1), Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57924">
        <property type="entry name" value="Inhibitor of apoptosis (IAP) repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM35116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="357" mass="39415" checksum="3C37851A7CD9944C" modified="2014-04-16" version="1">MGMTTRSQPSPTPEAANPTISPEYPNVEDFSLAEDDSHDEDDSHVEDDSHDEDYFLVSITYDYSTITARARSFQGIVLAGATPLQLAQNGFYYRPSGVSNVACCFACQSTKHLSTLQCTPFEEVQQLHEEDCIWQIISCDLKHHLGTPNKPPSSTTAFPSPKPSTPTADSSTQTTDDSSIKSQTQSTPITFTSAKERLNTNLDCRSNPLPTIIDPEPQQPPTAHSPQLHQTIPSITSSPQNQQTTYASVLQRPVTSIPRPTPPVQEPFLPANPTLTIEDLHLRFHNKPSPFQVENKTSQRSTKRTRNKTVSVTQSLSRFLASALPAFSRFLTEMQPKSDACCPSHSYISHSRAMRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W6QH26</accession>
    <name>W6QH26_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Probable transposable element</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S04g001014</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM36133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QH26"/>
    <dbReference type="STRING" id="1365484.W6QH26"/>
    <dbReference type="OMA" id="CHTRSYL"/>
    <dbReference type="OrthoDB" id="4207519at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05225">
        <property type="entry name" value="HTH_psq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH psq-type" evidence="1">
        <location>
            <begin position="18"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM36133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="95" mass="10735" checksum="837F4BE236246A23" modified="2014-04-16" version="1">MPPIRSQSSKDSIEQEGRILLAIQAFKKQEFTNISIAARTFNVPRSTLRRRLDGIQCRATSRANSTKLTTIEEESLQKWILSMDSRGSAPRPSMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W6QHP8</accession>
    <name>W6QHP8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S03g000443</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QHP8"/>
    <dbReference type="STRING" id="1365484.W6QHP8"/>
    <dbReference type="OrthoDB" id="1659429at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="7"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM33719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="82" mass="9101" checksum="D89599D5CD1F3434" modified="2014-04-16" version="1">MRMLEPTINVLKSIAEERHVSVPAVALNYSINKGVLPLVGVRDAGQAEQDMQALGWRLTEDEIKQIEGVSLQGRRSSFMQHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W6QIK6</accession>
    <name>W6QIK6_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Nucleotide-binding, alpha-beta plait</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PROQFM164_S01g003234</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QIK6"/>
    <dbReference type="STRING" id="1365484.W6QIK6"/>
    <dbReference type="OrthoDB" id="439808at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052462">
        <property type="entry name" value="SLIRP/GR-RBP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48027">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN 87F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="102"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="107"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDM29422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="155" mass="16003" checksum="409D45E16C1D8413" modified="2014-04-16" version="1">MVANLPYDLTEDKLKEIFAAYEPVSAKVALRPIPRFMIKKLQARNERRKTRGFGFVNLASEELQAKAVSEMNGKDIDGRVIAVKVAIDSPGKEDDDINAVAETEETAAPASDAASAPAAAAAPAPAADADAAGAADAPAPAAAKENTAPSVTTEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W6QIP2</accession>
    <name>W6QIP2_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Cystinosin/ERS1p repeat</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PROQFM164_S04g000747</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Vacuole</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the laat-1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QIP2"/>
    <dbReference type="STRING" id="1365484.W6QIP2"/>
    <dbReference type="OMA" id="DMCIFIQ"/>
    <dbReference type="OrthoDB" id="8048523at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098588">
        <property type="term" value="C:bounding membrane of organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015174">
        <property type="term" value="F:basic amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015101">
        <property type="term" value="F:organic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034488">
        <property type="term" value="P:basic amino acid transmembrane export from vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034490">
        <property type="term" value="P:basic amino acid transmembrane import into vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.290:FF:000011">
        <property type="entry name" value="PQ loop repeat protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051415">
        <property type="entry name" value="LAAT-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201">
        <property type="entry name" value="SEVEN TRANSMEMBRANE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201:SF35">
        <property type="entry name" value="VACUOLAR AMINO ACID TRANSPORTER YPQ1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00679">
        <property type="entry name" value="CTNS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="4" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="13"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="222"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="255"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="295"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="354"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="111"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="120"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDM35866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="387" mass="42293" checksum="C6A2B2E456896D17" modified="2014-04-16" version="1">MFPSQAANLNIEALSGICGSISIACWVVVFSPQIIENFRRGSADGLSLIFLIIWLAGDVFNILGAVLQGVLPTMIILAVYYTLADIVLLGQCFYYRGFNLKEELSPSATPDLFAANGTSDEERNSAEHEPAPTERSSLIPKPNGHVQIQDPATNVAGQQPEDHTQMPSAGRRHSTNSFHDIFSSVDATHLSPATPFFEPTSDCARRRAQLARRRRISVLQSILFNFTAVALVCAAGVVGWFVSPAAKPASPDPEPITMDVLGQVFGYFCAALYLGSRLPQLLLNYRRKSTDGVSLLFFLFACIGNLTYVLSIMAYSPVCHGGSTEEVLGHHSHRAHCRPGEAAALYGRYVLVNLSWLIGSAGTLLLDMAIFIQFFLYRDSKGEEEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2024-10-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>W6QIQ7</accession>
    <name>W6QIQ7_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S03</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S03g000818</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QIQ7"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM34094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="73" mass="8038" checksum="3E40E7F8CE4BC475" modified="2014-04-16" version="1">MAFGSLENIILIRPIIHTGQYASHPVMKRAKALVDIHGPLERSGLPLIRARIGILPLMPESMTIRLQLLSSAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2024-10-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>W6QJ58</accession>
    <name>W6QJ58_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S01g003434</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QJ58"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM29622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="33" mass="3681" checksum="58D23D0078D188FF" modified="2014-04-16" version="1">MESPIIAGLGISPSSAKYYFLPSALLAHWYRQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>W6QJB3</accession>
    <name>W6QJB3_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Zn(2)-C6 fungal-type DNA-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PROQFM164_S05g000726</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QJB3"/>
    <dbReference type="STRING" id="1365484.W6QJB3"/>
    <dbReference type="OMA" id="FPCFSET"/>
    <dbReference type="OrthoDB" id="5319458at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052202">
        <property type="entry name" value="Yeast_MetPath_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782:SF2">
        <property type="entry name" value="TRANSCRIPTION FACTOR, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G12570)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="25"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="71"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDM36893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="628" mass="70113" checksum="7ECEF796541DF844" modified="2014-04-16" version="1">MSHMSVTATTFLDNPLLKVSRPVAACSRCRTAKIKCDGKLPACSACERVGKAISCSGASDEFAKGKERSYVASLEGYCEKLEKKISQMRARSTSLSAEGDGIPREMSITSVSSERALGPAHRREVSDIDDLVGDFGFLSVNATSRDFHGITSSTSFANLLLSVALVDSSPPSSPYSLPARHEATPLLQYYFDNIFVQLPFFIETSFWTSVDAVYQSGGRFAKPFDHWMLRMVLAIASASLSYHHNDKSHQRAWALVSEALTYAEEVLRPGSISGIQAILLLAQYSFVDPVRFRSWYLIGMAVKVAIDLGLHQDPPAEVLTNPDRLDIRRRVFHSIYCLDRGLSPAMQRTYSFSDGSVNVALPSITAPGALLEQTHIFLRSPGPALHIVKIRQILSAGYQEMHYSGRDPSPQPLVLIWTLCWRAREWFQQCPKNAPNHFSLLYRLELLYTIIILISPSHRYPILHDYSKALLFDRCMDYISQIHQVLENPSALPFLTYLDIQRVHQVGRIFVNVLSDNYDMLISAAVPAPPPVPAGTPEPPVLGDEDLFNCHARAIRCLSYIRDMLKYCDRKWDIHGHLEQFEDESASIEKTLMDGSVGYMSSQEIYCQDLLSGMPLAGDAYSGYHIGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W6QJC4</accession>
    <name>W6QJC4_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S05g000353</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QJC4"/>
    <dbReference type="OMA" id="CKQWHRE"/>
    <dbReference type="OrthoDB" id="4340602at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15489">
        <property type="entry name" value="PHD_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="3">
        <location>
            <begin position="216"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="279"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM36520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="345" mass="38669" checksum="62B069CC697EC915" modified="2014-04-16" version="1">MSDPQWLWDPLSICETGPIRETKTCCGITKKGDACKLIVKKDTLKEGRHKLNNLARGPFNLSTLDSQLSDLVSFFLCKQWHRERQHNDVKQRWFDAAVRNQADVQESPRQRFPHIIAEEIDGPQQEPASTALETDGFAPTWGVDAAFPRLPSPTWLEVTRPPGRDVTPGMLTMNRVPWNVSRDNPAILSIHNEYGGLHSLQIHTVRQESCPDGERCPICFEGDSDDLVMLQCGICKGVVHLGCMEGWLAHRLPGNNTSCPIHRCNGSFRALLRSSAVGNATGNSTAETPLEDTYTPVEETSVPTAPPQRRSTQTTRRSDRPRVFSSSSLIRRSPRSRRVPDRFLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W6QJG2</accession>
    <name>W6QJG2_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Choline monooxygenase, chloroplastic</fullName>
            <ecNumber evidence="5">1.14.15.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PROQFM164_S04g001032</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the first step of the osmoprotectant glycine betaine synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>choline + 2 reduced [2Fe-2S]-[ferredoxin] + O2 + 2 H(+) = betaine aldehyde hydrate + 2 oxidized [2Fe-2S]-[ferredoxin] + H2O</text>
            <dbReference type="Rhea" id="RHEA:17769"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15354"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15870"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="EC" id="1.14.15.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine aldehyde from choline (monooxygenase route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the choline monooxygenase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.15.7" evidence="5"/>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM36151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QJG2"/>
    <dbReference type="STRING" id="1365484.W6QJG2"/>
    <dbReference type="OMA" id="ITYFYPT"/>
    <dbReference type="OrthoDB" id="426882at2759"/>
    <dbReference type="UniPathway" id="UPA00529">
        <property type="reaction ID" value="UER00430"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019133">
        <property type="term" value="F:choline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019285">
        <property type="term" value="P:glycine betaine biosynthetic process from choline"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00680">
        <property type="entry name" value="RHO_alpha_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03469">
        <property type="entry name" value="Rieske_RO_Alpha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.380.10">
        <property type="entry name" value="Naphthalene 1,2-dioxygenase Alpha Subunit, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="entry name" value="Rieske [2Fe-2S] iron-sulphur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015879">
        <property type="entry name" value="Ring_hydroxy_dOase_asu_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001663">
        <property type="entry name" value="Rng_hydr_dOase-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43756">
        <property type="entry name" value="CHOLINE MONOOXYGENASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43756:SF5">
        <property type="entry name" value="CHOLINE MONOOXYGENASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00848">
        <property type="entry name" value="Ring_hydroxyl_A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00090">
        <property type="entry name" value="RNGDIOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="ISP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="15" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="14">
        <location>
            <begin position="42"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="359"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00014931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CDM36151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="405" mass="46954" checksum="7607785F6F2E1440" modified="2014-04-16" version="1">MWRIFSAGTTAKEDPPHGLPASWYRSEAMYQLERRAIFSKRWMLLTHSSRFKKPGDYLSFTIANFSFFLIQDRDGTINSFHNVCRHRAFPVVQSSSGTTSILSCKYHGWSYGLKGNLAKAPRFETVPDFDKTQHSLFPIHVHVDKAGFVWVNLQAGETDVKWEDDYEKVDEEPRMQDFDFAAEFKFDHYWEMELDANWKGVIENYNECYHCATSHPLINGVSDLPKYRVEPKARYMEHHIFNKEGSDSQFRRAITYFYPTTSVTVTDKFFYIQRMIPVSATSSKIENEVYRHRDATDEEFENINAFYRQVLDEDKELCVGTQENLNAGVFTNGELHPSKEKGPIHFQSSVRQMVIEHRKNEEKQGGSEIWPATPNPQFSKGSAEDESFCSQLDASSCMAKPELAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W6QJH4</accession>
    <name>W6QJH4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lipopolysaccharide-modifying protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S01g003545</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QJH4"/>
    <dbReference type="OMA" id="QACNSVI"/>
    <dbReference type="OrthoDB" id="202415at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006598">
        <property type="entry name" value="CAP10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051091">
        <property type="entry name" value="O-Glucosyltr/Glycosyltrsf_90"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203:SF107">
        <property type="entry name" value="GLYCOSYL TRANSFERASE CAP10 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203">
        <property type="entry name" value="KDEL LYS-ASP-GLU-LEU CONTAINING - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05686">
        <property type="entry name" value="Glyco_transf_90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00672">
        <property type="entry name" value="CAP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase CAP10" evidence="2">
        <location>
            <begin position="187"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM29732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="464" mass="53325" checksum="6ABF641ADB224D9A" modified="2014-04-16" version="1">MTASFPIRPRRGLSLLCVITAFSFSAIIVIWFGMNSDREYIHPVLTQLIPAGHCACESSTTFQCSTCLTCPEPGLQTDRSPVWSFEYARDGHNETLNKSQCKAAFPGLFEDVARGGKFWSSHGRLSSVELGAIKIEHGMARAFISNGQLYVVTARSKGEDHRRKILGTLSSIHRALAADPERASRRDFEFVFSVEDKVDDVTNPEWPVWVFSRTPTEEGVWLMPDFSFWAWDNRDNYMGPYDQVVERIKRRDIPWSEKTPQLVWRGKPSFAPKLRRALMEAARDKSWGDVKQVDWNTGSNVLKMEDHCHYMFIAHVEGRSYSASLKYRQACNSVIVAHKLQFIQHHHYLLVADGPNQNYVEVERDFSDLAEKMEPLVNDTEAAKRIANNSVTTFRERYLTPAAEACYWRSLFDGYAGVWNGTVEQWSDRKDRERGLRYESFVLLESVKMYEFEAAITEQWQAIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>W6QJL5</accession>
    <name>W6QJL5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Sulphonylurea receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PROQFM164_S05g000841</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM37008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1365484.W6QJL5"/>
    <dbReference type="OMA" id="KSIKMMG"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18579">
        <property type="entry name" value="ABC_6TM_ABCC_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18580">
        <property type="entry name" value="ABC_6TM_ABCC_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000055">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000066">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000838">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044746">
        <property type="entry name" value="ABCC_6TM_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044726">
        <property type="entry name" value="ABCC_6TM_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056227">
        <property type="entry name" value="TMD0_ABC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF399">
        <property type="entry name" value="ABC TRANSPORTER ATNG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24357">
        <property type="entry name" value="TMD0_ABC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="81"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="166"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="265"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="319"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="494"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="537"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="912"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="947"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1040"/>
            <end position="1061"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1129"/>
            <end position="1153"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="14">
        <location>
            <begin position="291"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="627"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="14">
        <location>
            <begin position="912"/>
            <end position="1188"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="1225"/>
            <end position="1455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="580"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="864"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="618"/>
            <end position="627"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CDM37008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="1467" mass="161367" checksum="9FEE516E23B9E308" modified="2014-04-16" version="1">MALNASDTWDLCPQAADRHFGPSIDARCRGGFDFTLTFEQSILSIAPSALLLLIVPFRLYWLSRTSLKTNVSFSLACSSKLLAAVALFGVQVALLVLWGRNPQVQTVATIPAAALSLVDALSICLLSYMEHTRSIRPSTLLGVFLLASLVLDIPQSRTLFLMGDQTPMAAVFTAATGLKVILLMFEAQSKIHELRLPYRHHPPEATANVWARTLFWWLNPLFFRGFARLLSIEDLFSMDSKLATFHLRERMQASWARRAHSNSPYALIMATISCMRWALLSAVGPRLAKIGFTYAQPFLISRVISFVEAPASEQLRSHALGLMAAAFLVYISIAITTVLYKREMYRMIAMARGSLVSLVYSQTLQMPDSYDESAALTLMSTDIDRVTVGLQNIHEVWARITEIAIGMWLLVDQLGAVAVLPIGLIVVCTFANSQLSKLIVGKQKVWNAAVQKRIAITASMLGSMKSMKIMGMTEVVESSVQEYRRKEIQSAMGFRWLALWTNTIASAPLIFAPVLTFVVFVAQATARGTDSLSTNQAFTSLSIITLVTQPASLLMFAINESAAMKGCFDRLQKFLRAPAGSDSRGVTGLGGSRSGDSSLEVSLSHPNGTMREGEKVPETTTHSTPTIKVQQVTIRPAPTVDPAISQVSMDCPEGSLTLVVGPVGCGKSTLLRAVLGELPCDAGTIAISTKNIAFCAQSPWLPNGTIKDVICGFCDEEKIDHVWFQTTIHACALEEDLSQLPHAEQTVVGSRGVTLSGGQKQRVALARAVYARRSIILLDDVLSALDQKTEALVVDRLFGEQGLLRRLQTTILLVTHSVRHLNIADQVIVLTREGKVREVLSGQDIQKKKTDTATSDYDVAGAEDVASAPQPSSKPRPKIKAPGPDDADLTRQTGDMAVYAYYFRSFGWPRTFGFIACTALFTFATTFQQIWLQWWTNVNGGYIGKYMSVYVVLAVAAMLSRCLTFWWALIWMSPISSLNLHRILLRVAIGAPLSFFAKTDSGVILNQFSQDIGLIDRVLPLCLIRMVVQIFQILSQTALIAMGSSYMSVCIPICAVTVYWLQRFYLRTSRQLRFLDLESRSPLYSHFLETLEGLSTLRAFGWQEKFQETNTKLLDTTQRPFYLMYCIQCWLNLVLDLLVAAVGVVVIALAVLLPHMTSAGTIGLALNNVLGFNQALAVLIDSWTQLETSLGAIARLKNLEQTVKPEYQEGEDTIPPDTWPEHGAIELKEISASYSPSIPALKKISMSILPGQKVGICGRTGSGKSSLLLSLLRLLDLDSGSIAIDGYDLQTLPRELVRSRLVAIPQEPFFLSESVRINVDPSNKLPDEAIINALKKTKVWDAIEKRGGLDAQMKEQPLSQGEQQLFCLARTMLRSGKILILDEATSNVDAETDQVMQGIIRDEFQDYTVLTVAHRLDTIMDSDVVAVLDQGRLAEYGPPRDLLARPSMFADLVGRSSVESAVTTPSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>W6QK50</accession>
    <name>W6QK50_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Zn(2)-C6 fungal-type DNA-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PROQFM164_S02g000106</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM29957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QK50"/>
    <dbReference type="STRING" id="1365484.W6QK50"/>
    <dbReference type="OMA" id="DLDECDC"/>
    <dbReference type="OrthoDB" id="4337792at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051430">
        <property type="entry name" value="Fungal_TF_Env_Response"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31944">
        <property type="entry name" value="HEME-RESPONSIVE ZINC FINGER TRANSCRIPTION FACTOR HAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31944:SF131">
        <property type="entry name" value="HEME-RESPONSIVE ZINC FINGER TRANSCRIPTION FACTOR HAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="30"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="64"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="739"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="739"/>
            <end position="748"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM29957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="802" mass="90264" checksum="7FC7312705F2876D" modified="2014-04-16" version="1">MENHQDNLSPDHDEVENSRAPQRRRRPPLSCTVCRKRKLKCDRSLPCGQCVRSKTTAQCVFIGAQPDPTSDQRRMSPPQLPHGGVEDQAGRKSGMFVFDSKLGPNSTSNRVSKRARSDELHELRSRLRVLENSLGKSSHLQTPETSVCDIFSEVDTANSSENVGVDDRVRFLPDSSFRGKKTKTRYFGRSHYTTTVSFFKDIGTFMRRGRCRGGAKDKEYTDMKQFKTELWSREIQEHQRDFREQPFMLNELVPRRNVADRLLQLYLDTFETTYRILHIPTFLRQYADYWANTQPTDMAFVAQLLAVMAAGSCFYVPSPGQEDRDIFQKPAMKWIMAVQSYISCTFLSPEIDFRMLQTQTLLLVARLGVASDADVAWASAGSLIRSATIMGLHRDPARFHKARPFYSELRRRLWTTIVELDLKFSLDRGAPPSVDLDECDCDPPSNWDDADLIPDMEDNPAPLSTALYTQSFYQTLLAKTLPLRYRIAKKINSLRFNLSYDDALRMGDELSRSMQHASSLFEDNSPSIALGESGRHRFAQSLHLFIVRKFLLALHRPFSLSVVRLPKCSYSRKICLEESLGILSQMELPLATENIIYPNITQLGSGMFRDETFHAAITACVELSLQANEMSMSTTSGMDGVNSSVLMSMIQSQQGVMLQAVERTADNFGRRIGPGGTGCKPFFFLNIILASVKSRVKGEDPLCNVDTASKRSVRICRAILNGLTYEEAKISVDNCPAQTSIPSGTNPAPATPRDIDPTSLLSNDFGDFTPTDLGGWFDGLDYTGPELWDWDADLSGNLPTFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W6QK96</accession>
    <name>W6QK96_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="7">UDP-glucuronosyl/UDP-glucosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PROQFM164_S06g000194</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792020">
        <property type="protein sequence ID" value="CDM37233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QK96"/>
    <dbReference type="STRING" id="1365484.W6QK96"/>
    <dbReference type="OMA" id="VWQLKQN"/>
    <dbReference type="OrthoDB" id="5835829at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016906">
        <property type="term" value="F:sterol 3-beta-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000100">
        <property type="entry name" value="Glycosyltransferase family 1 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000009">
        <property type="entry name" value="Sterol 3-beta-glucosyltransferase UGT80A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010610">
        <property type="entry name" value="EryCIII-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050426">
        <property type="entry name" value="Glycosyltransferase_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004276">
        <property type="entry name" value="GlycoTrans_28_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48050:SF27">
        <property type="entry name" value="GLUCOSYLTRANSFERASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G04880)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48050">
        <property type="entry name" value="STEROL 3-BETA-GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06722">
        <property type="entry name" value="EryCIII-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03033">
        <property type="entry name" value="Glyco_transf_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyltransferase family 28 N-terminal" evidence="5">
        <location>
            <begin position="71"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="Erythromycin biosynthesis protein CIII-like C-terminal" evidence="6">
        <location>
            <begin position="386"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="605"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="784"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="605"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="805"/>
            <end position="822"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF06722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM37233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="822" mass="90475" checksum="45D7984C43451C11" modified="2014-04-16" version="1">MEEPPRRPSTLERNQFTQDGTKVKDDGRIDIDLDSKVGREVSKLIPFLHAEHLQPQPEPSGDFECGLELNIVIQVVGSRGDVQPFVALGNELQRHGHRVRLATHGVFESFVRDSGLEFYSIGGDPSELMAYMVKNPGLIPQMKSIQEGDIQRKRVMVGEILQGCWRSCIEDDSVTKTPFVADAIIANPPSFAHIHCAQALGIPLHMMFTMPWTSTRSFPHPLANLKYSTTEPKMANYLSYGIVEWLTWQGLGDVINDWRKSIDLEAISLTEGPRLAETLKIPFTYCWSPTLMPKPTDWPAHIDVCGFFFRAPPDFTPPADLAAFLQSGPPPVYIGFGSIVIEDPLAMTATLVKAVRSWGGRAIISRGWSKLGEEESDDQIFYLEDCPHEWLFQKVAAVVHHGGAGTTACGLRFGRPSLIVPFFGDQLFWGNMVASRGVGPIPIPHRTLNAENLAEAIRFCLHPDTLTAAGDLAREMTEEAGVSAAVASFHRNLPIDKMKCQFLDSEPAVWQLKQNGKTPINLSKMAAGILLENSRIDTRDLKAYETKTIFIMTRRWDPITGGTSSVLGMYKDILTASSDVVIRPYKEITRAHQQSQPELVVIEPTNQSERSPSEGISRTPGTNQTDEDWIVAGKAIGGSAKSVGRIIAYYYKGVLVDIPGAVNEGLRAVPRLYGEEVKDYDNIRDFKSGVAAASDNFRNGFTTGFADIFRQPYEGAQKDGFMGAIRGFVQGPIGMGTKAASGALGLIAYPGQGLAKSLHSAMHSKTRNQLLKARLTESEYLARQSGKAQSSCPDVIEAFEDQQRQPRNSASSTNPNRAGSQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W6QKR2</accession>
    <name>W6QKR2_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Short-chain dehydrogenase/reductase SDR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S06g000385</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792020">
        <property type="protein sequence ID" value="CDM37423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QKR2"/>
    <dbReference type="STRING" id="1365484.W6QKR2"/>
    <dbReference type="OMA" id="PCDLTKR"/>
    <dbReference type="OrthoDB" id="47007at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24321">
        <property type="entry name" value="DEHYDROGENASES, SHORT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24321:SF8">
        <property type="entry name" value="ESTRADIOL 17-BETA-DEHYDROGENASE 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM37423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="253" mass="27405" checksum="850F59611DCEC56F" modified="2014-04-16" version="1">MAPRLLNKICLITGTGGSMGRAAALKFAEEGAKIVGCDINTVTDAATIKAVRELGGEMISMSPCDLTKRENCEQFVNLAIKTYGRIDVLYNNAAMVYMSWLDDGKDDDWYKTIDQELSLVYLLTRVAWPYLKESGASIINVGSANGWIAIRGVPAIAHTATKGGVIAMTRQFAMEGREHGIRANSISPGLIQTLQTAPLLEDPQWRSDLTQKIMIGRIGQPEEIAAVASFLASDESSYITAADIRVDGGMTAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W6QKW3</accession>
    <name>W6QKW3_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S03</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S03g001531</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QKW3"/>
    <dbReference type="OrthoDB" id="76567at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM34804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="86" mass="9613" checksum="3FC018A8BE0A2E8E" modified="2014-04-16" version="1">MIIPFDELEPSNPLCAQLLRIPPLAIHAIPTQQPYSVQEVYVQPNHIVGAPLSLLFVAIYDRPPRPGEHDIPLNASGFLEITKMLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W6QKX0</accession>
    <name>W6QKX0_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S03</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S03g001541</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QKX0"/>
    <dbReference type="STRING" id="1365484.W6QKX0"/>
    <dbReference type="OMA" id="DVERWAP"/>
    <dbReference type="OrthoDB" id="371463at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="172"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM34814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="213" mass="23944" checksum="9D6D77123741BB3C" modified="2014-04-16" version="1">MPVYMLHGFRWPRAGFTGIRVYIVLHNLEEAAAEYIQQPLTTELIAESFHKTQADLVTRLPELSFIEQYDPADETSGTVSQDHAYISTRVLEMPEDGGGGGAGENIDCVEQGSGLTDDQMAALEELRDRLAPGEKIGWYLVYNGDPERWYPDSEEDYGSEDESEDENQTRRQSQAQGQAQSQAQSQKGSPKEPPRPQSYTTRLTRFFNRMSSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W6QLM9</accession>
    <name>W6QLM9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S06g000296</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792020">
        <property type="protein sequence ID" value="CDM37335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QLM9"/>
    <dbReference type="OMA" id="GIDETWE"/>
    <dbReference type="OrthoDB" id="4390692at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM37335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="127" mass="14171" checksum="763F0FEDEDC28871" modified="2014-04-16" version="1">MKELMPETATSPNKLAENQAAIFHENKNGNKAYRGDLLAKQISLLTIQLRVTEKLQIGTDWRWHLVHFSKDTKLENVRKEGYLIVLSNTITITPGGVLKEGSYIYIINEPVISAGATAIFIVPPPLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W6QMT2</accession>
    <name>W6QMT2_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S10g000012</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792024">
        <property type="protein sequence ID" value="CDM38198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QMT2"/>
    <dbReference type="STRING" id="1365484.W6QMT2"/>
    <dbReference type="OMA" id="SWFALIT"/>
    <dbReference type="OrthoDB" id="3350591at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022085">
        <property type="entry name" value="OpdG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053204">
        <property type="entry name" value="Oxopyrrolidines_Biosynth-assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38797:SF4">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38797">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP85-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12311">
        <property type="entry name" value="DUF3632"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM38198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="260" mass="29310" checksum="A641612400B1F314" modified="2014-04-16" version="1">MVAITDDIFASRLAILQDLFSDSVSAQHAAEHLASISLADESDLEGGITSLWSLIFKCAYNFPEHHDKLVNVLVQLSKLPNAKKSNGDSIVLYDMQVWKDLPMLGWQFRDEWNAGVPDGPPDARQKAISQIINRDKFTARLMATKEPVFAYSWFALITLREALETPAHEYSPGKVEALIRAAAAWISILGADIYQWNEGFDGALGKGGPLWKGQCGFSKERWQFWKERFGELATIELEETGEEERTAAWDAKRMMEEIEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>W6QNG6</accession>
    <name>W6QNG6_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Nuclear transport factor 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PROQFM164_S04g000540</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QNG6"/>
    <dbReference type="STRING" id="1365484.W6QNG6"/>
    <dbReference type="OMA" id="RPRGNAY"/>
    <dbReference type="OrthoDB" id="339151at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990861">
        <property type="term" value="C:Ubp3-Bre5 deubiquitination complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034517">
        <property type="term" value="P:ribophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00780">
        <property type="entry name" value="NTF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.50:FF:000003">
        <property type="entry name" value="Nuclear transport factor 2 family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002075">
        <property type="entry name" value="NTF2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018222">
        <property type="entry name" value="Nuclear_transport_factor_2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039539">
        <property type="entry name" value="Ras_GTPase_bind_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10693:SF20">
        <property type="entry name" value="AT27578P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10693">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEIN-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02136">
        <property type="entry name" value="NTF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50177">
        <property type="entry name" value="NTF2_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="NTF2" evidence="5">
        <location>
            <begin position="62"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="392"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="181"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="228"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="263"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="310"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="465"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="193"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="280"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="310"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="503"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDM35659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="526" mass="55736" checksum="1A70ECDD53B91AF1" modified="2014-04-16" version="1">MADMTQVPINGNYPAQHGYPESYNHASVTMNTAASFQPAQSSTPTTVTPTDQQKNEISKDEVGWYFVEQFYTTMSRNPDKLHLFYSRRSQLVFGTEAESVPVTVGTKAINEKLSSLKFQECKVRVLNVDSQASFDNILVSVIGEISNNSEPSRKFVQTFVLAEQPNGYYVLNDIFRYMAEEPEEEPEQPTPAAPTAEAPEAVAEVPAEEHQVIDEVTLSDVDEKLEEVEANEQVEEPKEAAPQTNGVPAEEAAPAAVLAVEAENLNDEEPATPEPSPIAEKGEVPEKETSTAPAAPKTWASIATTSFAAKAAAAAKASAAQAAPAAQVTPAVPTAPKSAAPAAPAAPTAQPAAATPAPAEVARSPEAPSTEAGWQTAGDGHKKSQPRVEETVLAYIKNVNDKVDASLLKQTLARFGKLKYFDVSRPKNCAFVEFNEPAGYTAAVAANPHQIGSEQILVEERRPRGNAYGSNAFPAGRGGGAGRGRGDRAGSQGRGGFQREGRGGFTPRGRGGNVAAKGRPSQPQAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W6QNM2</accession>
    <name>W6QNM2_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PROQFM164_S14g000012</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792028">
        <property type="protein sequence ID" value="CDM38513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QNM2"/>
    <dbReference type="STRING" id="1365484.W6QNM2"/>
    <dbReference type="OMA" id="LVTKGMH"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF1">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="450"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM38513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="535" mass="60684" checksum="47B444B6889C7C4C" modified="2014-04-16" version="1">MPGFATYLLGALGAIVIARLVLSLFKRPSLPLPPGPKPVPLIGNIHQLPKSLQWLELYHWSKKYGPIMHLSMAGQPLIILSTHQAAHDLLNRRSSRYSDRPRLVMAGELVTKGMHMLLRPYNGQYRLHQKMEAPLLTLRAASNYRPLQDLESQQLLWDVLGEWDKFGEKGVDFHHHFERAMASTIYCLNYGYRLQTGYEKELMDGKRVQAEFARTGQVGAYIVDSFPSLNHLPKFLAPWKKEGEELFELERQLHVGNLRKGLSSGKWNFAKHMKASSEAAGMPEVELAFDLGILADAGLDTSTVALDWFIVAWITSGSRGWVKKAQQLLDEVVGKDRLPNFEDRPKLAYIDAIASETLRWRPVVVQGVPHFTKTEDEYMGYHIPANSTVLPNAFAITRDEAVFGGDVDNFIPERWLAEESANEHSDICGFNTSALKDLPHTGFGFGRRICTGRLIARNQLFIQMARMLWSFDVEAGVVDESTGARHKVHDMDCTEGFVTLPKPFRMNEYLFFSRWDLTSQRKVGRNLVLAETIHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W6QNR5</accession>
    <name>W6QNR5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Probable transposable element</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PROQFM164_S02g001397</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QNR5"/>
    <dbReference type="STRING" id="1365484.W6QNR5"/>
    <dbReference type="OMA" id="CVNSFHF"/>
    <dbReference type="OrthoDB" id="5876363at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032221">
        <property type="term" value="C:Rpd3S complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15532">
        <property type="entry name" value="PHD2_CHD_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15534">
        <property type="entry name" value="PHD2_PHF12_Rco1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052819">
        <property type="entry name" value="Chromatin_regulatory_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47636">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATORY PROTEIN RCO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47636:SF1">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATORY PROTEIN RCO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="6">
        <location>
            <begin position="527"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="324"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="444"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="871"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="18"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="163"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="459"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="926"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="948"/>
            <end position="961"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM31247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="969" mass="106768" checksum="6016D573B39D8C86" modified="2014-04-16" version="1">MDTVRATMRRVSKRLLSKKSEADKASKEKKDAAAAQPLPPAPTGSTQSERRQGSSKPAQRRKLQKKPPGTSKPTTQYRTMKPIGEYPSPVEYRAAGVAPPSERAHSVATVPTNVPRDEAERLSPVSGVESPPTDKGHVEIAEEAALASTSTGAETVADESIRSSTTTPADAASPTLPSADITHKYLAVLMSLPLRPSDKYDLVKLRGVMKFAIISSIENDNEWCVVGLLYFWSNAMDDEFKLSLIANLSENDGGDKQLQLALQTILNNSLIEAQRWYQKYVRSTANAADIPSCSESSQPAANSVGAEPSFKVSDIYRDTSGPRVEENFLSGKSNTAPLKRPKKPCRVNENAYKRKRQWEMDPDHEEKMRAVRARLEAESYSEAVVQYSAIRTQIGPPDAIQHPYDMENIDAGIDGDIDAFNRSRSLPVPGSILDIPLVKGPEPAAPSVYSDGASAVARKTGKPVSRRQREKAKGPEVPQRARSLSVDTTVSSLSSLSNSAYSVRFNDWSGGHEARQMPNSIEPPENSDDCHQCGKGGDLLCCDTCINSYHFECLDPPLDPKNPPQGEWHCPKCSIRNSFSTLIAHSKHYKKTEFQPPQDIKEHFHGVDEGIVFDGDYARNLKHQRYYKAAPHLPRLTKAPKQDGPTIYANPMLLREYDNKGDCIRCSKCGFTSQGIHPIITCDYCPCRFHLDCLDPPRAHPPNPKVGWMCPNHVTPDDMIATKEINGSNERTRRVRRTKNMAYIDCDIMLPDDPNQSLFDEDWRDKRARFLGGDVVLNFITAVKEDHHEREKEYARIVERKCLELTKQLTSDYLNRAENAGITNNIAQNGLPAEFTQNVSHAVNNMIAGAPVSTEEFDAATALLGMATSQPPAVGEGHIPEAAGPASPVAQKPLSRIDEESTLGSSHAPTSPPLGTSHPPNASSDAESHHSDSELLPRIPVFNRNKRSRADDHGSAGERAQKRQYTKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>W6QP05</accession>
    <name>W6QP05_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">3-isopropylmalate dehydrogenase</fullName>
            <ecNumber evidence="4 14">1.1.1.85</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">leu2B</name>
        <name evidence="16" type="ORF">PROQFM164_S07g000069</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>(2R,3S)-3-isopropylmalate + NAD(+) = 4-methyl-2-oxopentanoate + CO2 + NADH</text>
            <dbReference type="Rhea" id="RHEA:32271"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17865"/>
            <dbReference type="ChEBI" id="CHEBI:35121"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.85"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="14">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="14">Binds 1 Mg(2+) or Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="14">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 14">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.85" evidence="4 14"/>
    <dbReference type="EMBL" id="HG792021">
        <property type="protein sequence ID" value="CDM37721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QP05"/>
    <dbReference type="STRING" id="1365484.W6QP05"/>
    <dbReference type="OMA" id="FRYSLDM"/>
    <dbReference type="OrthoDB" id="419183at2759"/>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00072"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003862">
        <property type="term" value="F:3-isopropylmalate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:L-leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.718.10:FF:000006">
        <property type="entry name" value="3-isopropylmalate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004429">
        <property type="entry name" value="Isopropylmalate_DH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00169">
        <property type="entry name" value="leuB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42979">
        <property type="entry name" value="3-ISOPROPYLMALATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42979:SF4">
        <property type="entry name" value="3-ISOPROPYLMALATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="12 14" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="5 14" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="7 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 14" id="KW-0520">NAD</keyword>
    <keyword evidence="9 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="15">
        <location>
            <begin position="6"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CDM37721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="366" mass="39529" checksum="0C19F7BE8E3AA2EB" modified="2014-04-16" version="1">MAKNFNILILPGDGIGPEIMAEAVKVLKFFETPQRKFELRQELIGGCSIDAHGKSVTEEVKQAALDSDAVLFAAVGGPKWDNQRRGLDGPEGGLLQVRKAMDIYANLRPCSSTSPSASIAKEFSPFKQEVIEGVDFVVVRENCGGAYFGRKVEEETYAMDEWGYSEAEIQRITRLSAEVALRHNPPWPVISLDKANVLASSRLWRRVVEKTMAAEYPQVKLVHQLADSASLILATNPRSLNGVILADNTFGDMISDQAGSIVGTLGVLPSASLNGLPGDKTLKTRPYGLYEPTHGSAPTIAGQNIANPVAMILCVALMFRYSLSMEDEARRVEDAVRKVLDSGIRTPDLGGKAGTNEVGDAIVSAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W6QP26</accession>
    <name>W6QP26_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tachykinin family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S09g000086</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792023">
        <property type="protein sequence ID" value="CDM38170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QP26"/>
    <dbReference type="STRING" id="1365484.W6QP26"/>
    <dbReference type="OMA" id="AGHMQTR"/>
    <dbReference type="OrthoDB" id="3469466at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540">
        <property type="entry name" value="TRANSCRIPTION FACTOR (ACR-2), PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540:SF5">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="117"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM38170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="598" mass="65809" checksum="A13D668A44A4AC76" modified="2014-04-16" version="1">MSSRKKQKKDSIHFVNARPASETERLKAQRLVRAHVGRWISETKDRSAGESSSSRIRPVRALPAVAHAGPGPGPGPSYTLVSRPSSSHRGSNPGQFTFAHNSRSNQAAYRDSPFPPSQASDSSDSSSSDDASTVTTFSSEALAVIRFNDRSSPERLERNLSGVFDPFATYPAPKSFEPEMINLSERYLTGVVWPGLAPRPLNVRAAANKWFDLSMADPALFTAFMFGSLCHLRVQWQNNWVPGTVFGQRERRALQLCEMESIKLINQAVRDPDRAVSDAVLLSVICMAHHQAEEKLVQQHRRTPFNPPFLRLQWIDVYGCLPPNMIHIKGLLQLVKLRGGLPNIPTEGLAATISFSDIMSCSVLCVHPCFDFWPLADSRLGWSVQEMLGFGPSDVDQGFGRLQEIGATHQMAEAFQAVHTYIGIIKASLNFTPDTSLLADQRNLTQHTLLSLSPASDISTFFSHPTRAATYEACRLAALIFGVGVLFPIPAQNTPLSTLARLIQAVLFKPSSSELWCSPSTRVPLIWVLTLGGIAANDAPERAWFASALGDVTRRTGLNSWASIKSVLATMLWYEAACDRAAEDLWQEGASKYSYAIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W6QP80</accession>
    <name>W6QP80_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S04g000785</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QP80"/>
    <dbReference type="STRING" id="1365484.W6QP80"/>
    <dbReference type="OMA" id="KMYTLAI"/>
    <dbReference type="OrthoDB" id="433738at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46035">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46035:SF3">
        <property type="entry name" value="TRANSLOCATION PROTEIN SEC72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="157"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM35904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="214" mass="23669" checksum="2CFA6C42D0B7261B" modified="2014-04-16" version="1">MASEIDIYNQYPLYMDPSTKALSLPQSSAQTPSQTAAINAELEELNQLHRALISLDPPNIPPPPLPVNPKRSAQISKLRDSANAAHRKSNYDEAIKLYSYAIDMALSRPGWEPIGVAREELSGLYANRAQAHMAMQAWPDALVDAKASVDSKPIGNVKAWWRIAKCLAEMSRYEEARRFLHKSLDIEGKDSEGGKELFSLLGEVDRALLRGLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W6QPR0</accession>
    <name>W6QPR0_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="6">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PROQFM164_S04g000960</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM36079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QPR0"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF45">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDM36079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="98" mass="11010" checksum="7F896968709D7A6C" modified="2014-04-16" version="1">MAVVFLYCFQFIFTVSYCGLTFLYAAEMVLLQIRAAVNAVSTATMWAFSFLIASVTPLGFPTIGSRCYIIFNVINATIILSVYFFFLESKVTEQSSLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W6QQD3</accession>
    <name>W6QQD3_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S05g000092</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QQD3"/>
    <dbReference type="OrthoDB" id="4240420at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM36259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="106" mass="12489" checksum="91200873A74B5ABE" modified="2014-04-16" version="1">MKIKFTGNEPGSYFVCVWSYLLPAKRRININTLCTNCLEETNLLSSKDQREFIYKKKDQIIFERRVVWAKQEWDLWVTSRECQRINESVQHNGGLCVHLFGGVGIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W6QQW3</accession>
    <name>W6QQW3_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transposable element</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S11g000049</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792025">
        <property type="protein sequence ID" value="CDM38346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QQW3"/>
    <dbReference type="STRING" id="1365484.W6QQW3"/>
    <dbReference type="OrthoDB" id="4366832at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM38346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="66" mass="7642" checksum="4746A2AB365A5438" modified="2014-04-16" version="1">MRLHRLSTRTYLILADLEAVQSGSLRLLYLDGFRNIVREGRLDSEIDDLFGVVTNRYTEEDLANLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W6QRE3</accession>
    <name>W6QRE3_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SIT4 phosphatase-associated protein family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S05g000462</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SAPS family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QRE3"/>
    <dbReference type="STRING" id="1365484.W6QRE3"/>
    <dbReference type="OMA" id="HAYIACE"/>
    <dbReference type="OrthoDB" id="295029at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019903">
        <property type="term" value="F:protein phosphatase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007587">
        <property type="entry name" value="SAPS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12634:SF8">
        <property type="entry name" value="FIERY MOUNTAIN, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12634">
        <property type="entry name" value="SIT4 YEAST -ASSOCIATING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04499">
        <property type="entry name" value="SAPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="69"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="503"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="601"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="799"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="862"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1086"/>
            <end position="1120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="76"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="507"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="545"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="558"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="617"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="808"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="871"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="888"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="928"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="945"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1033"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1094"/>
            <end position="1106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM36629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="1120" mass="121974" checksum="51A2DD749F1DB1E1" modified="2014-04-16" version="1">MFWRFGGYANLSTIDTLLDKPDLTLEELLDEPETIQELKQLNTKLIEYLREDHALKRLMEYVTAPSLVNDDEDDAKDTSEKGKDDAASAEQTDMDEEKEGDLRDILDPDDLDKVEKKRLTHAYIACEILSSETWSILESMMANPAYLGEFWGFLRRPPPLDSLQASYFTKVNETLLDKKTDEMLEFLKTLDGIVPALLQHVDNPMVMDLLLKIISLEKAEGGQGTVDWLRSQGLIPNLLSFLSPDRPASVQTSAGDFLKAIITISANASPNDQSCIGPNSLTRQLVSTECVQQLIDAMLKGGNPLTVGVGIVIEVIRKNNSDYDPESLGGPDTMLTTYDPIYLGTLLRLFAKHIPQFMALIQSSQHTIHEGNKLKTVERGKLNSAWGGQIEPLGFDRFKTCELMAELLHCSNMGLLNEPGSDEYVRQRDEERERLIREGGFDTRGFDTHQDEHSGVDTAADFANDSALDSGSPEDAKVTEVPHVGEDDGFEDVGASGDLVSAKADADTTATANSQPTETVSETSPSEITEPEPVSSEETTDKSESSTTPIDPSSPTTGLSDQVSAMNLESEPQDEQQEPGKDNQEPVASLSQDVPAPLFSKEQASESDSAPADQSEEPSSLIEQVEETSVPNDGGDEDSAEQYIQLDTDGRPVVGDYLKIQFVENKVVPTILGFFFRFPWNNFLHNVVYDVIQQVFNGPMERGYNRALAVDVFDTGRITTAIVEGQKRSDETQRTKQIRLGYMGHLTLVAEEVVKFSERHPPELLSRSVMESVLNPDWIEYVEQTLSETRERDNAILGGVRPDISVGPRQTSLNNTNSGQGFSNSALADVGLNGGIGGSTFQSFDLGQGGVSGGAFGGGGTSLLSGFASSSDDEDEEMEDQDERDSGNADQNDNDNVFTSSASQPIPILPPPPAPLSLGPSRARRQLAARLAAQKQQPSENEGDGDYRGAEGSEDRESDWPDNPFVIAGIDDPADAGSSAFPNSDFGSADGKHSPTFPESGFSPPDSLSTNSSEDEGDGHAESVRRQVRVPLEVEDDDDDEMGEMVGPSGIGMMDSDDEDEAIINESLGYSNLSGPARYNNFRSRAVSSHYDDEQNDSSDGEDDGLVEIMVPGRKASTSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W6QSU6</accession>
    <name>W6QSU6_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S06g000135</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792020">
        <property type="protein sequence ID" value="CDM37174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QSU6"/>
    <dbReference type="STRING" id="1365484.W6QSU6"/>
    <dbReference type="OMA" id="WLSHETA"/>
    <dbReference type="OrthoDB" id="5429780at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="207"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM37174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="443" mass="49971" checksum="2112C62657717DAC" modified="2014-04-16" version="1">MSTSNDGMQTNILVPDDAVTLQNSGLVSSPSSDGTRRIHKRRLNRSSDEEEQHLPLTPVSISSSSDSFVSIPDHLVSLAALEHLGYNSETATLIWEYWTNWPPGEPKRETDDTDNGVLFIDVAEGHLDYSPDTCSENDAEWFHCMNLYGITRELQEAIMDPKFRSIRLTDSCKSWIRDTFQLRNRALQAVQEASRERDMASRREASRPGQSSSGRRSISDSLRMVPWLSHETALSEAATTAASRAPGHTTIYKGIDQALITELFDHNGNLDFGCLISRSRCDFSGRQDDLYFAIDREVAELYACYIKHRSTCSGVVIIHISIPNSVIESLSIPDIQFNYWPNAEWKSLIFHCRQGKKLPSKLRKYKLAKLIIGTICGKPNLVISRMRSPDEITEHMVLKTSDGRNAVQYVFKGDDGDTLLEECSSVTVFPLTSRQFQAWLERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W6QTC6</accession>
    <name>W6QTC6_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S02g002913</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QTC6"/>
    <dbReference type="OrthoDB" id="10475253at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM32762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="410" mass="45759" checksum="2EA50A688B890D65" modified="2014-04-16" version="1">MTTSFWGLLGRLAINSKPQFPRSKPILAATKAPGNQNACGGAQYQLGHSLERQTCHLPQFFTLNKPVLASTATAMIRMRLVWFSLPSPGWPVPVSVRPLYTWRSSCETVQIRPRETERLYFGHHIPNSHGRRRRRHSDCGPSFSPIFHLWVNPRGLSEVATREMRRSVLLRLHLNRREHDRALLRGLDCRVHVFQASFELLDRDHIPYYKLIYYGSIGQAASGIFTGHFVVCALCRTRLTWSLAKYAHRAYNTVNVKVPTAYRSRVMKNGSAEIDLGTCEPNNHMAPENLMFLLAASPTPGTSGAVPGAMTKPSGSGRMSQVCAEVWCGCLVRAFRDLKKQNIDSRIQKVNILIPRVNITSIGVCQVPSPARDVLSSANSLRLDATRTTEINHVYSSLATTVGSWGCIGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W6QTN9</accession>
    <name>W6QTN9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="5">D-3-phosphoglycerate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PROQFM164_S02g003058</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QTN9"/>
    <dbReference type="STRING" id="1365484.W6QTN9"/>
    <dbReference type="OMA" id="KWNHDLY"/>
    <dbReference type="OrthoDB" id="9991913at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030267">
        <property type="term" value="F:glyoxylate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016618">
        <property type="term" value="F:hydroxypyruvate reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12168">
        <property type="entry name" value="Mand_dh_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000526">
        <property type="entry name" value="D-mandelate dehydrogenase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050223">
        <property type="entry name" value="D-isomer_2-hydroxyacid_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996">
        <property type="entry name" value="2-HYDROXYACID DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996:SF281">
        <property type="entry name" value="D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE NAD-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase catalytic" evidence="3">
        <location>
            <begin position="69"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="4">
        <location>
            <begin position="124"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDM32907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="348" mass="38202" checksum="AD1CDB991A2999F9" modified="2014-04-16" version="1">MTKPIVLHLGDDIRWNHDQYSKFQDVFEIRRSYSMSRPEFIRALKERQFGDFFAIYRPFWNTGGEMGNWDEELISLLPDSCKVYASAGAGFDWVDTAALAKKGVVYCNAAAACTESVADAAIWLIISTFRLFSWSHIAARALDVDAFVDANRNLAMVSHNPNGHTLGIIGFGQIGRRTAEKAFLALNMKIHYYDIVQMPAQLEAVSKATYHKTMDSLLAVSDCVMVATPFSGETLLNASLLAKMKDGSRLINIARGKLLDESALVDALKSGKLAAAGLDVHYNEPRVSPELASMKNVEMMSHNAGASVDSHIGFERLGMENITAFYQTGKAVTPVNAHLVAKATGSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W6QU91</accession>
    <name>W6QU91_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DUF202 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PROQFM164_S02g003248</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM33097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QU91"/>
    <dbReference type="STRING" id="1365484.W6QU91"/>
    <dbReference type="OMA" id="SVACHCV"/>
    <dbReference type="OrthoDB" id="199599at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003807">
        <property type="entry name" value="DUF202"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052053">
        <property type="entry name" value="IM_YidH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34187:SF1">
        <property type="entry name" value="DUF202 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34187">
        <property type="entry name" value="FGR18P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02656">
        <property type="entry name" value="DUF202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="163"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="DUF202" evidence="7">
        <location>
            <begin position="113"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM33097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="241" mass="26814" checksum="89A47F031A94B975" modified="2014-04-16" version="1">MTKVPAQTSGPRRPSGAILRNTRPRVNDNIPDPREALELQRIQTREDNELDYSTPSASSGDEYHVVTRRTTARALASRADAERRRQARKGAWGKLTRFWTHNITLTVAHKSSRDYFALERTFLAYLRTSLTVAQQGVLIAQLFRLQAAEELADRLGFGQVGTPLSVACHCVAIIVALVGAYRFWRQQNAIARGRVYAGGWDMNSVGVLLGCITITVLVVSVAIIVEVDVHPSIFFRRILAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W6QUA0</accession>
    <name>W6QUA0_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PROQFM164_S02g003259</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM164</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ustYa family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM33107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QUA0"/>
    <dbReference type="STRING" id="1365484.W6QUA0"/>
    <dbReference type="OMA" id="GVEHDCI"/>
    <dbReference type="OrthoDB" id="3687641at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021765">
        <property type="entry name" value="UstYa-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365:SF4">
        <property type="entry name" value="CYCLOCHLOROTINE BIOSYNTHESIS PROTEIN O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365">
        <property type="entry name" value="YALI0B05434P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11807">
        <property type="entry name" value="UstYa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00035112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDM33107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="260" mass="30084" checksum="7E1E2036E0C7D12A" modified="2014-04-16" version="1">MWPLKPRGSDSKYREINNNDGEDTALPVPEDHRHWNLLLYIVISILATGWTTTAVLYWKSYTAPKISGKFPLGTFTPIPEDVFKPVRRVFQPDERYIGNSKEVDHHWDDLVAGHDAVWIEDPDKWGLPEGIVAPFDHPHETDPPQHDFYVISILHQLHCLNMVRFQFWQARDGVDLDTEHDAVKWNLHVLHCFEYLRQAISCGGDLIIEGSSPIKVGKGHATSVTGWGVEHDCIDFELLRQFQIEQERKFNLTWQHDFLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W6QV08</accession>
    <name>W6QV08_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Glycoside hydrolase, family 32</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PROQFM164_S08g000020</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the glycosyl hydrolase 32 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792022">
        <property type="protein sequence ID" value="CDM37969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QV08"/>
    <dbReference type="STRING" id="1365484.W6QV08"/>
    <dbReference type="OMA" id="TWRPHTH"/>
    <dbReference type="OrthoDB" id="202537at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004575">
        <property type="term" value="F:sucrose alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005987">
        <property type="term" value="P:sucrose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18621">
        <property type="entry name" value="GH32_XdINV-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.560">
        <property type="entry name" value="Exo-inulinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001362">
        <property type="entry name" value="Glyco_hydro_32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013189">
        <property type="entry name" value="Glyco_hydro_32_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013148">
        <property type="entry name" value="Glyco_hydro_32_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42800">
        <property type="entry name" value="EXOINULINASE INUD (AFU_ORTHOLOGUE AFUA_5G00480)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42800:SF3">
        <property type="entry name" value="GLYCOSYL HYDROLASE FAMILY 32 N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08244">
        <property type="entry name" value="Glyco_hydro_32C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00251">
        <property type="entry name" value="Glyco_hydro_32N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00640">
        <property type="entry name" value="Glyco_32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004879882" evidence="6">
        <location>
            <begin position="20"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 32 N-terminal" evidence="7">
        <location>
            <begin position="83"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 32 C-terminal" evidence="8">
        <location>
            <begin position="462"/>
            <end position="655"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM37969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="668" mass="72190" checksum="2A1722DF2B54AFCD" modified="2014-04-16" version="1">MNIIKVAAVLISISAGATAQDYNAPPPNLADLPPLSLFETWRPHTHVLPPNGQIGDPCAHYNDPETGLFHVGFLHNGTGIAGVLTDDLVHFYDVNPNGGYSIVAGGPNDPLAVFDGSVIPSGVDGEPTLLYTSVSALPIHWTLPYIRGSESQSLAVTYDGGQNFSKLEIPPVIPEPPEGLDVTAFRDPFVFQNGPLDEILGNTDGTWYTIVSGGVKEIGPGLFLYQNTSPDFEQWEYLGEWYHEPANSTWGNGDWSKVFGYNFETSNVFGLDREGYSHNGSPFMTIAVESSYVPIQPSISSLHAQLWAAGSISIPEGENVTFVPDMVGVLDWGLAAYAAAGKVLPASSQASTASGAPDRFISYVWLTGDVFGGVVGFPSEQQGWQNTLLTSRELYIKAIPNVVNNRLVNEIGSWRLAASSPSTGKCVKLETLGIDIAREPYNAMKAAPSFTEPDQTLTSSGIIPFGRSPETKFFILEAEIDFLARSSDLQAGFQILASDLESTTVYYQFSNESIMIDRSETSAAANTTTGIDKSPESGRLRLFDINDCCGADCGHCGHGGHGCGHKGKHGEPYSTKCKSEISSESHAHNSSSNGVCEDRIETLSLTILVDNSVLEVYANSRFVLSTWVRPWYQNSTGIRFFQNGEGEVSFSNIRVADGLYDAYPDRSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W6QVI7</accession>
    <name>W6QVI7_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Rhodopsin, archaeal/bacterial/fungal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PROQFM164_S09g000055</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the archaeal/bacterial/fungal opsin family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792023">
        <property type="protein sequence ID" value="CDM38139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QVI7"/>
    <dbReference type="STRING" id="1365484.W6QVI7"/>
    <dbReference type="OMA" id="ILWTAYP"/>
    <dbReference type="OrthoDB" id="10261467at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009881">
        <property type="term" value="F:photoreceptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007602">
        <property type="term" value="P:phototransduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15028">
        <property type="entry name" value="7tm_Opsin-1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001425">
        <property type="entry name" value="Arc/bac/fun_rhodopsins"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28286">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28286:SF2">
        <property type="entry name" value="BACTERIORHODOPSIN _OPSIN, NOPA (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01036">
        <property type="entry name" value="Bac_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00251">
        <property type="entry name" value="BACTRLOPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01021">
        <property type="entry name" value="Bac_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0157">Chromophore</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0600">Photoreceptor protein</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0681">Retinal protein</keyword>
    <keyword evidence="4" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="127"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="218"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDM38139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="302" mass="33236" checksum="D9BE8F7349C008F6" modified="2014-04-16" version="1">MIQPPFDQFATLTAPATTSSVAPIPTIIPGYEVYQELHDTGKRTLWVVTVLMGVSSLVFYTLAARAPLSKRIFHILTSLITTISFVIYLALSTGQGIITKHDRVHESHKHVPDTHTDYARQILWLRFVNWAITTPLLFINLALLSGLPGANLLIAIVAHLIMLTTAVFGIFSGHGRERWVWLTLTCISYLVVIHHIGFHAQRAAKSKDIQTRRFFGSVSGSAIAMLALFPISLAAGALALRLSVDTETILFAIQDVFTQGILGYWLLFTHESSPGIALYMEGFWSHGVGNEGAIRISDEEGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W6QVN0</accession>
    <name>W6QVN0_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S09g000095</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792023">
        <property type="protein sequence ID" value="CDM38179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QVN0"/>
    <dbReference type="STRING" id="1365484.W6QVN0"/>
    <dbReference type="OrthoDB" id="3350591at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022085">
        <property type="entry name" value="OpdG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053204">
        <property type="entry name" value="Oxopyrrolidines_Biosynth-assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38797:SF4">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38797">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP85-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12311">
        <property type="entry name" value="DUF3632"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM38179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="326" mass="38673" checksum="076F02BB9BF2426D" modified="2014-04-16" version="1">MRDDYTEWERFSHPDPDEEDPPTLDEVQTLREFAETFGTANAIAAEDAARQLMSLVDEGRVVEERQNNVVDKGERVSWLLWDAAIDMTRYQPAILKLIEAIRALPQLERTEEQIRTGCFEDRLETWRSLEAFDYIWSETYSRCWEMRYGPYPYYGWTEFHSANAFYAHFLAAYPPESPDLRELTVALRLIVFALEQDPWTHAQQPPPQWQGHRYRDTGRPTDYMQMLNADVHAMVPFFEIAGHIIFGFVGKRDLSLLEKLKKRDSNLWHGDSLFSLERWEFWKTRLRWISEQDELMERTRADARKIVQLMQGIEQQNREIRLGSQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>W6QXU9</accession>
    <name>W6QXU9_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">NADH-cytochrome b5 reductase</fullName>
            <ecNumber evidence="20">1.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="primary">cbr1</name>
        <name evidence="23" type="ORF">PROQFM164_S03g001081</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">NADH-dependent reductase for DPH3 and cytochrome b5. Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase, predominantly CBR1. By reducing DPH3, also involved in the formation of the tRNA wobble base modification mcm5s 2U (5-methoxycarbonylmethyl-2-thiouridine), mediated by the elongator complex. The cytochrome b5/NADH cytochrome b5 reductase electron transfer system supports the catalytic activity of several sterol biosynthetic enzymes.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>2 Fe(3+)-[Dph3] + NADH = 2 Fe(2+)-[Dph3] + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:71231"/>
            <dbReference type="Rhea" id="RHEA-COMP:18002"/>
            <dbReference type="Rhea" id="RHEA-COMP:18003"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:83228"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:71232"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17 20">
            <text>2 Fe(III)-[cytochrome b5] + NADH = 2 Fe(II)-[cytochrome b5] + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46680"/>
            <dbReference type="Rhea" id="RHEA-COMP:10438"/>
            <dbReference type="Rhea" id="RHEA-COMP:10439"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 19 20">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">Monomer. Component of the 2-(3-amino-3-carboxypropyl)histidine synthase complex composed of DPH1, DPH2, DPH3 and a NADH-dependent reductase, predominantly CBR1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion outer membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 20">Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.6.2.2" evidence="20"/>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QXU9"/>
    <dbReference type="STRING" id="1365484.W6QXU9"/>
    <dbReference type="OMA" id="VQIFMCG"/>
    <dbReference type="OrthoDB" id="432685at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090524">
        <property type="term" value="F:cytochrome-b5 reductase activity, acting on NADH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06183">
        <property type="entry name" value="cyt_b5_reduct_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000032">
        <property type="entry name" value="NADH-cytochrome b5 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000019">
        <property type="entry name" value="NADH-cytochrome b5 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001834">
        <property type="entry name" value="CBR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370:SF184">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00406">
        <property type="entry name" value="CYTB5RDTASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 19 20" id="KW-0274">FAD</keyword>
    <keyword evidence="5 19 20" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="14 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="12 20" id="KW-0520">NAD</keyword>
    <keyword evidence="11 20" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 21" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="28"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="22">
        <location>
            <begin position="56"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00037104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00038836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00047682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00049138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR601834-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU361226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="CDM34357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="305" mass="33257" checksum="FF9827BE05DEFFD7" modified="2014-04-16" version="1">MSLANIGTALVPSALLIASVYAIKPEFIAYAIAVAGVLAGYLVFSTSKPRKVLNPTEFQNFVLKEKNEISHNVAIYRFALPRSTDILGLPIGQHISLAATIAGQPKEVVRSYTPISSDNEAGYFDLLVKAYPQGNISKYLTELKIGDNMKVRGPKGAMVYTPNMCRHIGMISGGTGITPMLQVIKAIIRNRPRNGGNDTTKVDLIFANVNPEDILLKDQLEELEKEDDGFRIYYVLNNPPEGWTGGVGFVTPDMIKERLPAPAADVKILLCGPPPMVSAMKKATEALGYTKARPVSKLEDQVFCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W6R0R7</accession>
    <name>W6R0R7_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phenylalanine ammonia-lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">PAL</name>
        <name evidence="3" type="ORF">PROQFM164_S04g000308</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the PAL/histidase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6R0R7"/>
    <dbReference type="STRING" id="1365484.W6R0R7"/>
    <dbReference type="OMA" id="RFHHGGN"/>
    <dbReference type="OrthoDB" id="10051290at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016841">
        <property type="term" value="F:ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00332">
        <property type="entry name" value="PAL-HAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.200.10">
        <property type="entry name" value="Fumarase/aspartase (Central domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="entry name" value="Fumarase/aspartase (N-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.20">
        <property type="entry name" value="Phenylalanine ammonia-lyase 1, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001106">
        <property type="entry name" value="Aromatic_Lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022313">
        <property type="entry name" value="Phe/His_NH3-lyase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005922">
        <property type="entry name" value="Phe_NH3-lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023144">
        <property type="entry name" value="Phe_NH3-lyase_shielding_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01226">
        <property type="entry name" value="phe_am_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10362">
        <property type="entry name" value="HISTIDINE AMMONIA-LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00221">
        <property type="entry name" value="Lyase_aromatic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="L-aspartase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00488">
        <property type="entry name" value="PAL_HISTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM35427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="680" mass="74408" checksum="E2575B1AD6C8F857" modified="2014-04-16" version="1">MMRHLEHVQRAWSLLEKTRETESVILSGDQNSLEPAQLVAVARFSVIVSLSKSGSIEKRVQESIDTLNIHLNNGEDIYGVNTGCGGNANKRTKKLKILQQGFLQHHQAGILPGLPQSHDRAYALPEDVTRGAILLRCNSLIRGHSAVGMDKIELLIQALNKGITPIIPLRGSISASGDLSPLSYVGGLLEGNTGISVQVKGETLEAVMSAADALRQADIAPVTMDAKEALGIMNGTAPSAAAAALVLHDAHNLGVLVQLLTAMATEALQGSLDNYHDFISQCRPHPGQIEVADNIRSFLIGSHLSTKMNVKQQGLVQDRYALRTAPQWIGPLLEDLMLADRQVTTELNSSTDNPLIDVAGDRFHHGGNFQAASVSSAMEKTKTAIVMLGRLVASQCQEIINPILNKGLPPNLCFDDPSLSFTCKGVDINMSAYLSELAYLGNSVVSHMQVAEMNNQSVNSLALVAARYTANSVDILTMMCAAHFYVLCQALDLRALNQDFFDIAKPHLSALHKKIWPKTDRAVAFDDLWMGITDSWHRHNQSETESRCEEVARDSAHLIFDHYTRTDTDPSSYALIPKWTTDVTLTLIEDHQNTSKQFLACQSTPKYLAPATREMHIWIRHALQVPFHRGLVDHPGFLGGGVDDSRREKETIGTNITKIYMAIADGRATIPMSKAIQVMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W6R1C3</accession>
    <name>W6R1C3_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">coproporphyrinogen oxidase</fullName>
            <ecNumber evidence="4">1.3.3.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">CPX</name>
        <name evidence="7" type="ORF">PROQFM164_S04g000508</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; protoporphyrinogen-IX from coproporphyrinogen-III (O2 route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the aerobic coproporphyrinogen-III oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.3.3.3" evidence="4"/>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6R1C3"/>
    <dbReference type="STRING" id="1365484.W6R1C3"/>
    <dbReference type="OMA" id="VHANWRY"/>
    <dbReference type="OrthoDB" id="15318at2759"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00322"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004109">
        <property type="term" value="F:coproporphyrinogen oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1500.10:FF:000004">
        <property type="entry name" value="Coproporphyrinogen III oxidase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1500.10">
        <property type="entry name" value="Coproporphyrinogen III oxidase, aerobic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001260">
        <property type="entry name" value="Coprogen_oxidase_aer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036406">
        <property type="entry name" value="Coprogen_oxidase_aer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018375">
        <property type="entry name" value="Coprogen_oxidase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003727">
        <property type="entry name" value="PRK05330.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10755">
        <property type="entry name" value="COPROPORPHYRINOGEN III OXIDASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10755:SF0">
        <property type="entry name" value="OXYGEN-DEPENDENT COPROPORPHYRINOGEN-III OXIDASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01218">
        <property type="entry name" value="Coprogen_oxidas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00073">
        <property type="entry name" value="COPRGNOXDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102886">
        <property type="entry name" value="Coproporphyrinogen III oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01021">
        <property type="entry name" value="COPROGEN_OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM35627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="437" mass="49824" checksum="33FBBFAC7D6C0833" modified="2014-04-16" version="1">MATRSYTPLRRSLGQLSARSTRIAGRRAGPSFRGYSTEQKPREPKPFTVWRPYLRLAIGVPFIGGIIYSMMTEEVTELDAPSMVEVDEALKQSKINDSSPMRLRMEKLIKQHQQKIIEELGRVDGQQFKTDTWSRPNGGGGISCVLQDGNVFEKAGVNVSVVYGKLPRPAIEKMRADHKSFVGSDVESLDFFAAGLSLVLHPHNPMAPTVHLNYRYFETSDPKDPINGDKNWWFGGGTDLTPTYLFPEDAQHFHKTIKDTCDRHDATYYPQFKAWCDKYFYIPHRGECRGVGGIFFDDLDANFLQTSAGSSSNPQETLFSFVSDSLASFLPSYVPIIERRKDMLYTPEQKEWQQLRRGRYVEFNLVYDRGTSFGLRTPNARIESILMSLPRTASWAYMDPVSGTRTENMPVDEDDLTEDKASEKEIMDVLRHPRQWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W6R2V8</accession>
    <name>W6R2V8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phosphatidylserine decarboxylase-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S04g001038</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM36157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6R2V8"/>
    <dbReference type="STRING" id="1365484.W6R2V8"/>
    <dbReference type="OMA" id="ANACESQ"/>
    <dbReference type="OrthoDB" id="5973539at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004609">
        <property type="term" value="F:phosphatidylserine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003817">
        <property type="entry name" value="PS_Dcarbxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022237">
        <property type="entry name" value="PsiD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067:SF9">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_7G01730)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02666">
        <property type="entry name" value="PS_Dcarbxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12588">
        <property type="entry name" value="PSDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="L-tryptophan decarboxylase PsiD-like" evidence="3">
        <location>
            <begin position="44"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM36157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="443" mass="49604" checksum="7C73C52DB4DEABC9" modified="2014-04-16" version="1">MTDPNSEHHLHRYGNWMPADYKAHQEWLGGIIKKVDDESQKPLHPVLEEFRQLIESNTRIYMLLTSMFKEVPRKKRYGHDVTGNPEIRDYNHFLRVLNHLLTTAPSWTDKANRVGLVGLPINAVLDWPMGTPSGYAAFLDPEINAMIKKILNVWGEFLRSPASADVLNNTSHGWFGKTGRRDLTAVAKIGPLAQTELEFHDMFECDPYAPNHGFKSWDDFFTRTLREGIRPVADPEDGKVIANACESRPYRIAHHVKVRDHFWIKSQPYSVLDMLGHDELASQFVGGTIYQAFLSALSYHRWHAPVSGKVVKAYVVNGTYYSEPLFEGVGNPDVEQKDIDMAGQVTSQGYITSTATRALIFIEADEPAIGLVAFIGVGMAEVSTCDITVKEGDKLKKGDEIGMFHFGGSTHCLLFRKGVHVSGFPEPGLAENKPVRSKLAVVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>W6R3I6</accession>
    <name>W6R3I6_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Phosphotransferase</fullName>
            <ecNumber evidence="11">2.7.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">hxkA</name>
        <name evidence="14" type="ORF">PROQFM164_S05g000195</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>D-fructose + ATP = D-fructose 6-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16125"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37721"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:16126"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a D-hexose + ATP = a D-hexose 6-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22740"/>
            <dbReference type="ChEBI" id="CHEBI:4194"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:229467"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:22741"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; hexose metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the hexokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.-" evidence="11"/>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6R3I6"/>
    <dbReference type="STRING" id="1365484.W6R3I6"/>
    <dbReference type="OMA" id="ADCVQQF"/>
    <dbReference type="OrthoDB" id="419537at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005536">
        <property type="term" value="F:D-glucose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008865">
        <property type="term" value="F:fructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004340">
        <property type="term" value="F:glucokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019158">
        <property type="term" value="F:mannokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001678">
        <property type="term" value="P:intracellular glucose homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006013">
        <property type="term" value="P:mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000092">
        <property type="entry name" value="Phosphotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.367.20:FF:000004">
        <property type="entry name" value="Phosphotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.367.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001312">
        <property type="entry name" value="Hexokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019807">
        <property type="entry name" value="Hexokinase_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022673">
        <property type="entry name" value="Hexokinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022672">
        <property type="entry name" value="Hexokinase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443">
        <property type="entry name" value="HEXOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443:SF16">
        <property type="entry name" value="HEXOKINASE TYPE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00349">
        <property type="entry name" value="Hexokinase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03727">
        <property type="entry name" value="Hexokinase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00475">
        <property type="entry name" value="HEXOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00378">
        <property type="entry name" value="HEXOKINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51748">
        <property type="entry name" value="HEXOKINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 11" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="6 11 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Hexokinase N-terminal" evidence="12">
        <location>
            <begin position="27"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="Hexokinase C-terminal" evidence="13">
        <location>
            <begin position="227"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF03727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDM36362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="490" mass="54098" checksum="CD10A7439B66EE13" modified="2014-04-16" version="1">MVGLGPKHPPSRKGSMHELPQNLLGTIQDLEKAFTVDRAKLKEVVAHFAKELEKGLTVEGGNIPMNVTWVLDFPDGNERGTYLALDMGGTNLRVCEITLTEEKGAFDITQSKYKMPEELRTGTADELWEYIADCLQQFIEYHHEEGNLAKLPLGFTFSYPATQEYIDHGVLQRWTKGFDIDGVEGHDVVPPLEEILKKRGLPIKVAALINDTTGTLIASSYTDSAMRIGCIFGTGVNAAYMENAGSIPKLAYLNLPADMPVAINCEYGAFDNEHVVLPLTKYDDIIDRDSPRPGQQAFEKMTAGLYLGEIFRLVLIDLVDNHPGLIFNGQDVSKLRKPYLLDASFLAHIEEDPYENLTETLDLFELKLNIRPTEPELELIRRLAELIGTRAARLSACGVAAICTKKKIDSCHVGADGSVFTKYPHFQARGAQALREILDWAPNEKDKVVIMAAEDGSGVGAALIAALTLKRIKAGNLVGVRNMDDMKTLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W6R4F3</accession>
    <name>W6R4F3_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S05g000530</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the aldo/keto reductase family. Aldo/keto reductase 2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6R4F3"/>
    <dbReference type="STRING" id="1365484.W6R4F3"/>
    <dbReference type="OMA" id="HIMDSVE"/>
    <dbReference type="OrthoDB" id="1720422at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19079">
        <property type="entry name" value="AKR_EcYajO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000004">
        <property type="entry name" value="Oxidoreductase, aldo/keto reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050523">
        <property type="entry name" value="AKR_Detox_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364:SF15">
        <property type="entry name" value="ARYL-ALCOHOL DEHYDROGENASE AAD16-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364">
        <property type="entry name" value="NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="3">
        <location>
            <begin position="20"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM36697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="347" mass="39121" checksum="69C3B50EAD9449EF" modified="2014-04-16" version="1">MADNKMEYVRLGNSGLKISKIILGTMGYGSKQWQDWVLNEEDSLPLIEHAYKQGINTWDTADIYSHGKSEEIVGKALKKYNIPRNRVVILTKCFFGVDDEGKFPPIAASGKNDGPFVNRTGLSRKHIFDAVDASVERLGTYIDVLQIHRLDRDTPREEIMKALNDVVESGKVRYIGASSMAAWEFQSLQNIAERNGWHKFISMQNFHNLLFREEEREMIPYCRDSGVGIIPWSPIARGALARPWGSRSTVRENTDGALKMVVRSRESEADKAIIDRVEELAKKKGVSMAQIAIAWSLTHPGENPILGLHSVERIDEAVAAIKVRLSPEEIKYLEEPYVPKAVSALER</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W6R6I6</accession>
    <name>W6R6I6_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribonucleotide reductase, transcriptional regulator CRT10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S06g000394</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792020">
        <property type="protein sequence ID" value="CDM37432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6R6I6"/>
    <dbReference type="STRING" id="1365484.W6R6I6"/>
    <dbReference type="OMA" id="DVPYIPR"/>
    <dbReference type="OrthoDB" id="5591786at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014839">
        <property type="entry name" value="Crt10"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08728">
        <property type="entry name" value="CRT10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="416"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="428"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM37432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="719" mass="80842" checksum="CC1B8B6D4CB33EDB" modified="2014-04-16" version="1">MSFPPTSSTRAKTEREFVRYRPQVQALNIEAEEERFPDDVPRPTVSAWRCNLAAFSQRRNLLFTAQVEDIYVWIPSGPRQLLGSQPEMIIHPVMKEPDSAGYIDRSRPHTINHIIVDDLGVDEVLLLATDSGNVTGYNVEAIFSAINRSAKYGGGRPFDAHEIKPFFAEHVYLSAWGLATHKFSRLIAVSANTGDITVFAFALMDVVSENDGSSPNSSETSNLGGSGNTWVSIHNAELMQGLKRSMPRHRTRNLRLTYRGHFDNIPCVSFANFELDPNGLWMISTDILNNVSIWRVWDSLSPVDISSYDCLESGREQKGWFVLPLHPRRVQQHLLKFHACGCDPKRTMMDDQVVFDVTEAADYVEARSVLASQKIAAEEHATVSSIFLEDDIFPSGCVHTEFRPQLLSSEHNNTTLQASEIASPPDTVDTTDVSSEVSQDQQVASRRHSIRVRRGINNLVEEENEQWGPDFAAEVPAAEVDVLTGSVHHPTNPRFFPILHFSGNTITLNPYPLDHVLRTVSRSPLDSLVEHSPFYSCDRLNLVKYLPELGIVIAASQAGGVAIITLTWQEEIGHTFRLDWLLPFITQERDDGCPPLPLMGIAASPMPGFEIPPDVPCIPQDVNPKDQLKFNHRLLNPDEDEPYVANPPESWAFSPSGPDIIPSSEDPNLTIPETHAYASEIYQPHETWHGYHPSRHYRLLLLFSDLTVMSYEFWHDWRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W6R8H0</accession>
    <name>W6R8H0_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PROQFM164_S09g000078</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792023">
        <property type="protein sequence ID" value="CDM38162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6R8H0"/>
    <dbReference type="STRING" id="1365484.W6R8H0"/>
    <dbReference type="OMA" id="AVWWFLR"/>
    <dbReference type="OrthoDB" id="4356615at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056030">
        <property type="entry name" value="DUF7611"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056031">
        <property type="entry name" value="DUF7612"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056032">
        <property type="entry name" value="DUF7613"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056033">
        <property type="entry name" value="DUF7614"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24586">
        <property type="entry name" value="DUF7611"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24587">
        <property type="entry name" value="DUF7612"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24588">
        <property type="entry name" value="DUF7613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24589">
        <property type="entry name" value="DUF7614"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7611" evidence="2">
        <location>
            <begin position="555"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7612" evidence="3">
        <location>
            <begin position="712"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7613" evidence="4">
        <location>
            <begin position="847"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7614" evidence="5">
        <location>
            <begin position="1007"/>
            <end position="1134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="319"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF24589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDM38162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="1148" mass="126307" checksum="3C1E7D012D381FAF" modified="2014-04-16" version="1">MSADDPFSFLPAEQAKPAKKPHWKSKLFSKDKHKAALQQHQEIADFLSSRAPESAAAPPPIDPTPQTVAAHRFPSSQDISKHPPAKPVPAPASASASAPVLPFDNYASFNFSDQFQTVPNPSPASAKHGGRKGKGLRVGFSRQNPEVIGEGGDETESPTIEISRARERSDSRGTPGSDLSRPQLPNLRLDTSLGDSDARSRKEDADFLSTLSAGDGGARLKLHGDTEFAQRVRDKMQAEEGRALHHRYEEDALSPGVEDDDISTPPSPPSPPSPEPLIKGYNSGSPHEAAPTAGLPHAPSISLSMRSIVDSIRSPPSPSAERAPASLSPIDPRMPTNLIPGSPGKLSPIQAKAPPQDLSASNRASPPSREGQEPPPHSVQPPKFSLRNIANQVGNTAFSEFKEYNTQYQSSIELAAEEVKPLVETSLAEWIRAAVWWFLRGKTRLEAYARSRSTLPPTYAKQAVVDLGKALWINENIVPSHHELSRYGAMGVDALLAVASTTGDKDLADLLSIHHTLINHLRSLSMSIKRNNILAVINSDEGSPSQLDTSIWLRYPFYAPDVSAVLSGAATRSMLVDNAGKTPSLVHMMPLGDTSRYFSYGSMFVQVCVSSSDDDGQQQYAMPCALTIVRERADWYVFAAITSQSQLVNILIQSDRKQGPTWEDVEWQVRSHSMRVKLPRGFELDVLFKEDDFKTLWNIVKYTQKSENSLHPEAGETVVFENTIKIFQYMDPGTPKAFPPDPTERCRVRLFERSVTVTEGTGTRNAHRGFRIAILTSPKVKTLSSIRHIFGNGSPIVFGLLRGEDGAPALLLKVTEDGRTRSMLMTFHEAAERSKMHSVLLGMLPQEGEIKSPEFAIQSYCIEQPEDPFTGQPAVKYLQFPAGSVSVLDQEHAYVDHGYGPTILSEHLRAFVATEWGSVTDRINLGPGELKIGLDVQSKTSMSLFRSGQQDLTLSLADNLIRPELPGQLTGFLEKIKTKPTIRRLDFPTMQDLHAFEAAVTGFQVLYDGMATSFTISRRRSMVPIYKKWEASLARIQIVRQEKVIQMLAFFGDFHHGTCMNFVLKGTDIMQSFTRSGKFGIRMVDAKFALPKKDDNPASNFVCLDMPEYPIEHDDLAIAFDTEAARATFKAALPGSVREPSRMGSIRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W6PRD7</accession>
    <name>W6PRD7_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcription-silencing protein Clr2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S01g000249</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PRD7"/>
    <dbReference type="STRING" id="1365484.W6PRD7"/>
    <dbReference type="OMA" id="AMTVMSS"/>
    <dbReference type="OrthoDB" id="438224at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031934">
        <property type="term" value="C:mating-type region heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033553">
        <property type="term" value="C:rDNA heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070824">
        <property type="term" value="C:SHREC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030466">
        <property type="term" value="P:silent mating-type cassette heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038986">
        <property type="entry name" value="Clr2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031915">
        <property type="entry name" value="Clr2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018839">
        <property type="entry name" value="Tscrpt-silencing_Clr2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38046">
        <property type="entry name" value="CRYPTIC LOCI REGULATOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38046:SF1">
        <property type="entry name" value="CRYPTIC LOCI REGULATOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10383">
        <property type="entry name" value="Clr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16761">
        <property type="entry name" value="Clr2_transil"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cryptic loci regulator 2 N-terminal" evidence="3">
        <location>
            <begin position="65"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="Cryptic loci regulator 2 C-terminal" evidence="2">
        <location>
            <begin position="365"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="445"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="599"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="607"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="636"/>
            <end position="646"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM26440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="685" mass="76896" checksum="47106D87A6FFD053" modified="2014-04-16" version="1">MSYSSEDEDSNVNIIPMENFPSDGDMSTWPSSHYIERSDLRWRQLLAENWLKDMGTYEDGVIHTIEKLPDGYCLFERPRGTNPSMFDSFLFGHPSGRYFQSQLSFLPHFLSLVKNELDKCQCKPCGKMKMSEGTAVQGKAGQRTRRVVQPIIDERRPTDAEGPDYWRILIMKLKDKGALDEDIEQRFNFDWVLTHEWLSDYFMKLVLDPAYIPRRGELVLWIWQGLEDGCLMRNPETGFIEIFGNDNKWHGVPNWRAGVVTQIPEDEGHMVNIIEGSDNPRGLSYSGFRLETLPDPVGSDKSYSVQYAYVPLRNIKPFNTWQLYLNGQERGDIHPSIENAMTVMSSWSMVHKFHVIGTWPSARIYCKGIFVGAELLALHDTVRLRPHGFHHDQLKYGTVGEVTDVMVIEKIALYLSECIDDNEEQLAKHFTALISGKVFTTDPSRVTQEGPFQGRNPVSSGGSATGPIPLTTEEAIATFRQVGMGDYGPWYRMADGRTCNVSPHLIVGRCYEPLAAELMFGTHTMSYDLSGVMEGRQYSSQVDSRMPEGKTWFWGDCRVETLGLTEINGVECGLTAAQRENPRKWQAIIKISHGEVGHDLRGQAELPSSVGRPSKSSSSAPKGTSSRPRTGLEHIAQTSKLVSSVIGSVPDTEEDSFDDQVYGGISELGIGVGHSSGEDSDYSNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W6PRI8</accession>
    <name>W6PRI8_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Glucan endo-1,3-beta-D-glucosidase 1</fullName>
            <ecNumber evidence="4">3.2.1.39</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Daughter specific expression protein 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">eng1</name>
        <name evidence="19" type="ORF">PROQFM164_S01g000294</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of (1-&gt;3)-beta-D-glucosidic linkages in (1-&gt;3)-beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.39"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 81 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.39" evidence="4"/>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PRI8"/>
    <dbReference type="STRING" id="1365484.W6PRI8"/>
    <dbReference type="OMA" id="DTMFAYA"/>
    <dbReference type="OrthoDB" id="4473401at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052861">
        <property type="term" value="F:endo-1,3(4)-beta-glucanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042973">
        <property type="term" value="F:glucan endo-1,3-beta-D-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000920">
        <property type="term" value="P:septum digestion after cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.1170:FF:000001">
        <property type="entry name" value="Endo-1,3-beta-glucanase Engl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.420:FF:000008">
        <property type="entry name" value="Endo-1,3-beta-glucanase Engl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.98.30:FF:000006">
        <property type="entry name" value="Endo-1,3-beta-glucanase Engl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1170">
        <property type="entry name" value="glycoside hydrolase family 81 endo-[beta] glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.30">
        <property type="entry name" value="Golgi alpha-mannosidase II, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.420">
        <property type="entry name" value="Immunoglobulin FC, subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005200">
        <property type="entry name" value="Endo-beta-glucanase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040720">
        <property type="entry name" value="GH81_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040451">
        <property type="entry name" value="GH81_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31983">
        <property type="entry name" value="ENDO-1,3(4)-BETA-GLUCANASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31983:SF0">
        <property type="entry name" value="GLUCAN ENDO-1,3-BETA-D-GLUCOSIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17652">
        <property type="entry name" value="Glyco_hydro81C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03639">
        <property type="entry name" value="Glyco_hydro_81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52008">
        <property type="entry name" value="GH81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0134">Cell wall</keyword>
    <keyword evidence="12" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 81 N-terminal" evidence="17">
        <location>
            <begin position="228"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 81 C-terminal" evidence="18">
        <location>
            <begin position="561"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="128"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="132"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="172"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00074614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00075210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF03639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF17652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CDM26485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="922" mass="100505" checksum="06EACBC21EB78936" modified="2014-04-16" version="1">MVVAIDSLWNLSADHSQQTSPCVVPIWVFELRGGLILLEFIAHTSTEKAYCLPHVGNEVEATLQNTATEPARAFETQYPPSNSEDRLLIPESHPVYRVALEQDGHSSQQPFPQFDIIRFVDGLEDLLGSGGNTPAPTLTATGQSTGTGKSHPIQATTSAKQPENPAPIHTAGSVTYSPQAGPSTTVAHEPVHILSSSSVTSKTMPSQDIFQPVATGPVPANIKSRDDHPVQNQHANTTNPIATNKFYAGLFLGSQTNATFTQPYSLAWSKGGGSLKSWGMAVSHVQPHMLAYGPPNSKIPGNPVQYYINPIGLQSLIFSATELNQSSIMNVNQPKAFSAHAVIKPSEGSAKQIVFPVVQGMGYATAVYSDLQPVIESGVFFRKVVSAGSPRSGIFKYQVYLEDDMTWLLYATPADGKDPEFKLVSNSRLRGPQGFSGTIQVAKNPAGKSGEKFYDNSSGVYPVAGKISGSVTDDVGTYTLSWKKAGKDVTGTPLIMFALPHHVQSFDGATKSRITDINLRTTTKGNSTAVIGESWTMVEQSLPIDIGFAPWSTTQGSSNELSASAQHAILQAAPQELKQNISGQTDLNSMYYSGKALSKFATLVYTVNQLGNSSDLATDAFQKLKKSFDLFVQNKQQYPLAYDSVWKGVVSTAGYNGDLNQDFGNTAYNDHHFHYGYFIQAAAIIGSLDPSWLAANKEWVNMLVRDAGNSVPNDPYFPFSRSFDWYNGHSWAKGLFESFDGKDQESTSEDTMFAYAIKMWGQTTGDASMEARGNIMLSILGRSLNNYFLMEDDNVNQPANFTANRVTGILFENKVDHTTYFGANLEYVQGIHMLPLMPHSPFTRRKEFVRQEWQAMFAENASTPASKVEGGWKGVLYANLALIDPKSSWDFFAQSNFDYSWIDGGATRTWYLAFIAGLGGAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W6PSG5</accession>
    <name>W6PSG5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S01g000505</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PSG5"/>
    <dbReference type="STRING" id="1365484.W6PSG5"/>
    <dbReference type="OMA" id="WYEGRRV"/>
    <dbReference type="OrthoDB" id="446723at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277">
        <property type="entry name" value="ALPHA/BETA HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277:SF81">
        <property type="entry name" value="PROTEIN ABHD13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="142"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM26696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="419" mass="45941" checksum="7BD8D14414C80AAF" modified="2014-04-16" version="1">MVELKPIFRKAYWSLAAGGLLYVLCILSLTFPEVQRSVLYANKINPSLWQDVNQVEQFGFLRTQVQPFHLVTPDNETIYGWHLMPLHLCLEFEKELMENPSTGPAEDYTKTVAYKLLANDPNARVVVSFHGNAAHLGSAQRPATYNSMLSLSTPSNPVHVFAIDYRGFGVSTGNPTEEGLITDGVSLINFLTAGPLEVPTSRIVIVGQSLGTAVTTAVAERFAFGSSDPAAIQPAIKNADPFAGVVLLASFSSLANLIESYSFKGLTPPMLSPIMGYPRSQQWLLSHIVDHWDTAGRLARLTGVNTTSLNAVDMGYIDKSLDLTIVHAFDDAEIPWYEGRRVWEAATGRHVKGAPGAMTYLKSEDGNPSEVKIWKNEISNEDGSEVVKTVRWERIRYGGHNRVASGSVAGIAVMRAFEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W6PTG9</accession>
    <name>W6PTG9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Nuclear distribution protein nudE homolog 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">nde1</name>
        <name evidence="9" type="ORF">PROQFM164_S01g000870</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nudE family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PTG9"/>
    <dbReference type="STRING" id="1365484.W6PTG9"/>
    <dbReference type="OMA" id="NMAIERS"/>
    <dbReference type="OrthoDB" id="5877028at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005871">
        <property type="term" value="C:kinesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051642">
        <property type="term" value="P:centrosome localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000132">
        <property type="term" value="P:establishment of mitotic spindle orientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047496">
        <property type="term" value="P:vesicle transport along microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033494">
        <property type="entry name" value="NUDE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006964">
        <property type="entry name" value="NUDE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10921:SF1">
        <property type="entry name" value="NUCLEAR DISTRIBUTION PROTEIN NUDE HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10921">
        <property type="entry name" value="NUCLEAR DISTRIBUTION PROTEIN NUDE HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04880">
        <property type="entry name" value="NUDE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NUDE" evidence="8">
        <location>
            <begin position="134"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="195"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="375"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="549"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="44"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="236"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="260"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="297"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="310"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="330"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="388"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="454"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM27061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="599" mass="66089" checksum="C9B1E9E89AF44A98" modified="2014-04-16" version="1">MPAVDEPSSERKHTSSSYRDELAHYKAQYEQLEAELADFQSSSRELEAEMEKDIEASEKRERQLKEKLDTMRYEVDEWKTKYKQSKTEGNAVQNNLQKEITTLRDANRTLQLKLRDIEVANDDYERQARNTTSSLEDMESKYNIGIERGVLLEEEMRNGEQEREQLRIDNQRLRDELSDLKIEAEIIQEKLRNTEGHGLRRRKPTPLYHRSPATPQSVEIFDRSPGTATSSPVFATPPAKSSLASSTATPPSPPISESSVNIRKSINPYANSTPTFPRQRAGGADPVNSRTLHARTQPRTTHSRTPSLAYSNGAYSTSNGNNANANANSRPTPSMSISSRNSLTRMSTSRPPGLPKSGSLFQIRGLIGKMQKLEERVQSAKSRLPAPSDTSSRGSPRSGSVISDTPIVPSSITVRRNSRKRLSNSSLGSSARDSESTPSYPPPGHQSFGRTGESRPSSRTSFSSRGSFSQSVHSGVHVNARPESCSSRPGAKTPLGHYSTNPMTEARRPRSSLSNHAGQLPNIAGMSLIDEDQDIATPTVPHISQEFQRPSVTTTPTPIVKKRTISGIPAPRSFKTSIGPGTMPPPNRKTQVSDLGETF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W6PUN4</accession>
    <name>W6PUN4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g001411</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PUN4"/>
    <dbReference type="OrthoDB" id="3746940at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM27600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="81" mass="9267" checksum="FB923054A3E4124B" modified="2014-04-16" version="1">MAKGDEALAGREERNIASHRFPPDPENDRTIKFQGLYISVFNEDTQDRKTLEENVAEYKGFAVPKGYTTYVRGVEIVCWVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W6PUP7</accession>
    <name>W6PUP7_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g001426</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PUP7"/>
    <dbReference type="STRING" id="1365484.W6PUP7"/>
    <dbReference type="OMA" id="APSHHYH"/>
    <dbReference type="OrthoDB" id="4207123at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42095">
        <property type="entry name" value="YALI0C12166P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42095:SF1">
        <property type="entry name" value="YALI0C12166P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="83"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM27615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="198" mass="20525" checksum="36370CE89B3214E3" modified="2014-04-16" version="1">MSNNRPFLANFLAAFRAQSTYKPAQQVGATTSTLSSAQISQSARAIATKAANSAQGSSAPSSASAAAHHNHTHNHHNHHHTHTSSSASTTAPAGQVQGPSPSPSHHYHHDQSSLPSTPPSSTSTPIPINRGSADRQRRGSDSSSGSGGFRDAIGPEKWYIGGRTPAGEERFYRLGMVTKGGGRLGGSGRVGSIDQLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W6PUU1</accession>
    <name>W6PUU1_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidase M20</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S01g001804</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="2">The Mn(2+) ion enhances activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20A family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PUU1"/>
    <dbReference type="STRING" id="1365484.W6PUU1"/>
    <dbReference type="OMA" id="LMMVAQP"/>
    <dbReference type="OrthoDB" id="6119954at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05664">
        <property type="entry name" value="M20_Acy1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.360:FF:000017">
        <property type="entry name" value="Amidohydrolase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017439">
        <property type="entry name" value="Amidohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01891">
        <property type="entry name" value="amidohydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11014:SF63">
        <property type="entry name" value="METALLOPEPTIDASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G09600)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11014">
        <property type="entry name" value="PEPTIDASE M20 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005962">
        <property type="entry name" value="Pept_M20D_amidohydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="Bacterial exopeptidase dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="3">
        <location>
            <begin position="201"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR005962-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM27993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="420" mass="45201" checksum="41633F262438E1A3" modified="2014-04-16" version="1">MAKQRLSDILAAADVDLNPYEALYKHFHTHPELSLQEKATSERIASHLCQLGSYEVQTNIGGYGLVGTLKNGPGKAILLRADMDALPVKELTGLPYASSVTMADADGNEKPVMHACGHDMHITCLLAAAEVLARTRNAWSGTLIVLFQPNEERGGGAQAMVDDGLYSKIPMPDYVFGQHVMRMRAGSVGSRPGTIMAAADSLKITLYGRGGHGSQPHQTVDPVLLAAHVVVRLQGIVSREVDANDLAVVTVGSLQAGQTENIIADRAEIGIDFRTVKLETREKILAAIRRIVEAECVASGSPKPPLFTPTRRFPPTDNDKHVASQLAASFADHFEDFDGDTPRTNVSEDFSTLGTSQGLPCSFWFIGGIDPGLWDKGQKNEIPMEEIPGNHSALFAPVIQPTMKTGVDALCIAALTFLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W6PVA9</accession>
    <name>W6PVA9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WD40/YVTN repeat-like-containing domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S01g001621</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PVA9"/>
    <dbReference type="STRING" id="1365484.W6PVA9"/>
    <dbReference type="OMA" id="KLHQMKY"/>
    <dbReference type="OrthoDB" id="308449at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051959">
        <property type="entry name" value="PAK1-Kinase_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44675:SF1">
        <property type="entry name" value="P21-ACTIVATED PROTEIN KINASE-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44675">
        <property type="entry name" value="PAK1 INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="408"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="467"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="473"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM27810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="491" mass="53012" checksum="39CD6FF4B2F17673" modified="2014-04-16" version="1">MVKRKRTDASKDDKTAGTPPKVTKSIPTPSETPDAAVTVQVVTGSYERVLHGFTVGIPASSLKAKAEADSPAIQCMDTFLFEAHGSAIRCLALSPLPKPTDPVDAQKVMLASGSTDERINLYSISAAPPAVNEDYPSVPTFAGNKILENPRNRELGSLLHHTASITSLNFPSRTKLLAAGEDNTISVSKTRDWTVVSTIKAPNPKIQGRPSGDTAPPGAAPSGVNHFAVHPSMKLMLSVGRGEKCMRLWNLVTGRKAGVLNFTREVLQGVKESRWSTGEGRRIAWDSEGEEFAVAFEWGAVVFGIDSIPRCRLLPSPRSKLHQMKYVSLPLKGGEKEDFLAVSTEDGRVIFYSTKELKKAEDDTECSISHATPVAQVGGKEAGFPGRIKDFEILTLEGQAKEFRNDFLVVTGNSDGVVRVWKVTGKEVSAAKQGKRDTTQIGKLLTTNETGNRITCLAAFVMLPAEDPSTLIDSEDDSEEEVESSSDSDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W6PVW1</accession>
    <name>W6PVW1_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S01g001856</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PVW1"/>
    <dbReference type="STRING" id="1365484.W6PVW1"/>
    <dbReference type="OMA" id="THISRDY"/>
    <dbReference type="OrthoDB" id="3645574at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF37">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM28045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="296" mass="34568" checksum="7C54C4A7C8523F6B" modified="2014-04-16" version="1">MTRRLLKGEITYSFAKDQESDILHHLGYYGQQDRFFSYLDDRRDDKCHVSEVRYWLRGSFNICIPISTQNSRQQPRKRVILRFPLPYRIGDDFRPGNGDKKIQCEAGTYAWLQQNCPDIPIPRLYGFALSTGETFTELDQLPFLSRCFQSLRRRLLNWFCLPVPSNYILNPNQTEALPGRVASAGYLLLQCIEETQGTMLANTWFEKQQDSELRCNFLRELSRIFLSLSKTPLPRIGSFIINRDGFLTLSNRPLSMELQDLENENVPTHISRDYTYNTVESYVMDILGAHDSRLRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W6PW93</accession>
    <name>W6PW93_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PROQFM164_S01g002324</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the wax synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PW93"/>
    <dbReference type="STRING" id="1365484.W6PW93"/>
    <dbReference type="OMA" id="FRHIGTP"/>
    <dbReference type="OrthoDB" id="1077582at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044851">
        <property type="entry name" value="Wax_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032805">
        <property type="entry name" value="Wax_synthase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31595">
        <property type="entry name" value="LONG-CHAIN-ALCOHOL O-FATTY-ACYLTRANSFERASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31595:SF27">
        <property type="entry name" value="WAX SYNTHASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13813">
        <property type="entry name" value="MBOAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="281"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="314"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="353"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="393"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="Wax synthase" evidence="8">
        <location>
            <begin position="233"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM28513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="417" mass="46054" checksum="4B8C9E5D7DFA46F8" modified="2014-04-16" version="1">MSTSSNILQILFLYAAHCLIPVALLIATPKQSALRYLSIPCSIFIVYRAIPVATALGPGFVWCELARLFVTIIFQCLNLLLINPKDSNDLSSGAGQGFVAQIYAAARLFTDPRGINTPWQIKNAPPQPAYYKRRGMNTPPRGCFLVRQIAIAVWQYLALDVFATLALQQALEQEKSGMLPPVPQWDITTEQWIERIISNLTAGFVVSRILIDFHHRVFSIIAVGLGLDSPANCPPLFGRALDADTVRGFWGKFWHQLLQNPLTSVSAFITRDILGLTRRSLIARYMNVLIVFSCSGGLHLVLDIVQGIPAQESGAMLFFITAPLGLMIEDSVKALWKYFCGPSQKIPKPLWQRALGLTWSMAWLGVTSTGFFYPQMLRPQNQALVPFSVADRIGLPIQAGILLVGGAVLAKVFEVEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2024-10-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>W6PWJ3</accession>
    <name>W6PWJ3_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S01g002439</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PWJ3"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM28628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="62" mass="7110" checksum="EB3ED12745F3997E" modified="2014-04-16" version="1">MQMSAPVRRMGGMVPSKTVQIVIYRYHLTIQPAATDPLYITRDNRTYHVNADVIEQITFSIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W6PXY1</accession>
    <name>W6PXY1_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S01g002919</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PXY1"/>
    <dbReference type="STRING" id="1365484.W6PXY1"/>
    <dbReference type="OMA" id="CALAYFW"/>
    <dbReference type="OrthoDB" id="5985073at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004881143" evidence="2">
        <location>
            <begin position="17"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="225"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="257"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM29108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="285" mass="29981" checksum="73CB3DEB64E2B745" modified="2014-04-16" version="1">MLCLFAFAAALGQATATFSLDTAGPSWDYTTKDLAKTTSQACKDAYSASINCDETLLKIVASMDPDFDPQPSDLEAMCTATCSSSLSQYIKNVNAACSKDGDLAGLASGNNLIYEAPVATVGEVFQYKYGQACAKSGSDYCFLTYPASDDWAREDFPCSNECAIKFYQNAHKQLGSGYFFSYFVLGNQSSYWEETFAGGWETVVQCGDGGSDASSASTSASSTKTDVVDVSSSTSPISTKMADSTPSTPTASMNSMTSTTPARAASEATSTTATSGASRLRAPFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W6PYA4</accession>
    <name>W6PYA4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">YjgF/Yer057p/UK114 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S01g002811</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="YjgF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM29000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="50" mass="5584" checksum="1D3682C00D39A004" modified="2014-04-16" version="1">MESQYAGMNEEWNKVFADRASAPARATIGVRELPDTRMIVEVKAVAVVEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W6PYF7</accession>
    <name>W6PYF7_PENRF</name>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
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                <person name="Malagnac F."/>
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                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:protein dimerization activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
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        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="2">
        <location>
            <begin position="168"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="120"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM26999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="255" mass="29367" checksum="7ED72B98E3B5789C" modified="2014-04-16" version="1">MENANQTIQKDYSTLSHYCPWQDDRPQPISRDQWPAEEGLQWGSDPSFCYHGFSSPIGTWTEERLVQNLMRNMAGLCTAMDIDFDVPESIHEPSQKNLSELDGFTLPIFQTSMVPQNGRPSETPSPSSSSSQAQMFSLDDTECTQRASCVKARTQSKQRKRKCVQRPGQNLCHCRSEKKRREIIGDRYKELCHIVPGLERQSYTRKYVLEEAALWIQKLIQDNVALHQQLGELKEQEKLTQLRLFPVEKDEQVGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>W6PYI2</accession>
    <name>W6PYI2_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Zn(2)-C6 fungal-type DNA-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
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        <lineage>
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            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OMA" id="HAVNYHL"/>
    <dbReference type="OrthoDB" id="5296287at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053230">
        <property type="entry name" value="Trans_reg_galc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47654:SF3">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47654">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="89"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="167"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="770"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="124"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="174"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM28786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="864" mass="97142" checksum="898EB0A71017C2FA" modified="2014-04-16" version="1">MTAGEPSHTDKDGAVPPRETSTKQPTADIAPAGLRPLSIANTMSTIGAKRTNPGQASLSKTIAASQTKVAIPRQRVAAAPRYNRRVPRACSSCRQRKTKCSGDTPICRQCRELRATCSYPDGWREKTKKQVEALSEKAQEYENLLKELRGMVEFSAAERIRSLLDKYGPEVDGSSQSQSRSQSATPQDDIPENDEPSSPSSIGSLEAIDRVEEDINRSPHARATGYMGKNSEITWMQRLQREADQRAQGLPGSLEFGQDPKIDNAVALHAVNYHLDDLDISVPEPVQLYAMPPREVADHMFEAYLTTVHPFFPIINKPLFSAQYRTFFDSAARPGDKWLAILNMIFAIGAKHGHLIAAPWRGTEKDHLIYLTRARILSMNGDVLFSHPDLQQVQVEGLIAFYLLASDQINRAWRISALAVRSAITLGINMKSSSPATPDLSKEARYRVWWCLYTFEHLLGIMTGRSTCIRDGVCTSPFPIPFEEEQLQMPEAVEVLTDAALRDERINNVMASSRIRQMPLHPVNGKDASHHTRAKNTEWVKNLPINYGLCHLYYCDLTVVVQEIVNKVYSVDCVMVPWAQIEQRISELKSRTDIWKSSLPTGLDFTRKDDNGPDILRCKISLALHYYSARITLGRPCLCRRDARRRGAHPSFSHEMAVITLHSARHMLDLVPDEPDAIQLYRIAPWWCILHYLMQATTVLLLELSFGTVHMPEEENNFVALSKKAIRWLFAMSEQSIASRRAWQLCDLSLRKLAQGMKYDVSDMPSYPYTPEPKSTISPEPLAGQSVSQADGDYWGPQLEHLPVSVPEGPPREDHDTSTAELMTSLTADAQDSYFPYDPISGEFMRSFFPNSNSNSNENDNWEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W6PZN0</accession>
    <name>W6PZN0_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF1770-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g003312</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PZN0"/>
    <dbReference type="STRING" id="1365484.W6PZN0"/>
    <dbReference type="OMA" id="GWRHWNR"/>
    <dbReference type="OrthoDB" id="2430343at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140580">
        <property type="term" value="F:mitochondrion autophagosome adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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            <end position="53"/>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="183" mass="20823" checksum="00A1C5307C16DBF8" modified="2014-04-16" version="1">MADHAMDIPQILQSASINRNPDPSLDINPATTASEKRPVAVGPDSETNSIASDVVHPRQVIRPVRRRHTLPPLPDLRFEQSYLASIKDADTWGRVAWITTRDQVLLPLIQGTVWTLALSGWRFWNRNASVSGHTLGSRVRRWWYEVNNWHLPQLGSTRDHKQMSEVENFLQFYTAQFSDAGSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q0J7</accession>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
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    </dbReference>
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        <source>
            <dbReference type="EMBL" id="CDM27734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="231" mass="26331" checksum="DB0835323C21FA2D" modified="2014-04-16" version="1">MTCTPNPPVLTQLTLTLPSLLKSYQPGPDLQYHDRIDFDDDGDFELPPADIRLSDAKSPRMKEHGKPHLCVMLQRFYLRDLSVHEPTVGSRARLLGPHDCHSWCLAGTGYFLFFFFFWRRPASKSEDIEDTPLKDIIVGEQPEGTGEKIHAGDDVEARTPPVRKMGRIGWWRWVDGGFGGTSAYRVFQPSQKLQFASKKQKTTEDQQDDPLSLGDGTFYGLRRWRIQASYA</sequence>
</entry>
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    <name>W6Q0Q0_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
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    </gene>
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        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
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            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004879299" evidence="1">
        <location>
            <begin position="17"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM27774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="42" mass="4879" checksum="6DB9E28D79920D92" modified="2014-04-16" version="1">MYRCFILIFVLPAVQRCCIYSFLTRIPLSGDFCCCCFGDRCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q120</accession>
    <name>W6Q120_PENRF</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein family FLILHELTA</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">PROQFM164_S01g003478</name>
    </gene>
    <organism evidence="2 3">
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        <lineage>
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            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29666.1"/>
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    </dbReference>
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    <dbReference type="OrthoDB" id="5580261at2759"/>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28002:SF1">
        <property type="entry name" value="MIOREX COMPLEX COMPONENT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10306">
        <property type="entry name" value="FLILHELTA"/>
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    </dbReference>
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        <location>
            <begin position="16"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM29666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="210" mass="23398" checksum="532A4187940DEAAE" modified="2014-04-16" version="1">MASRPPNVLRYLRLQTTRHARSHASRRTISTPSPPQPPKPSQPIPNDSHSRLRRLNDRLPRFLRTYTTPLLGAPVTHITSFLILHEITAIVPIFGLVGAFHYGVWMPDLASQTGETNAFDEGAARFGRWLKKKGWVNESDVNTVADHETTAEKTVDRAGVRLVLEFATAYAVTKALLPVRLAVSVWATPWFARSVFTPIAKLAGRLFGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q2I8</accession>
    <name>W6Q2I8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Argonaute/Dicer protein, PAZ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S02g000684</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1365484.W6Q2I8"/>
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    <dbReference type="OrthoDB" id="10252740at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02846">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="paz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014811">
        <property type="entry name" value="ArgoL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032472">
        <property type="entry name" value="ArgoL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032473">
        <property type="entry name" value="Argonaute_Mid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032474">
        <property type="entry name" value="Argonaute_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003100">
        <property type="entry name" value="PAZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036085">
        <property type="entry name" value="PAZ_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003165">
        <property type="entry name" value="Piwi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22891">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08699">
        <property type="entry name" value="ArgoL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16488">
        <property type="entry name" value="ArgoL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16487">
        <property type="entry name" value="ArgoMid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16486">
        <property type="entry name" value="ArgoN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02170">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02171">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01163">
        <property type="entry name" value="DUF1785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00950">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101690">
        <property type="entry name" value="PAZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50821">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50822">
        <property type="entry name" value="PIWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAZ" evidence="2">
        <location>
            <begin position="439"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="domain" description="Piwi" evidence="3">
        <location>
            <begin position="730"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1040"/>
            <end position="1061"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM30535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="1083" mass="123814" checksum="5BA65D94969CFC3A" modified="2014-04-16" version="1">MAPKKAMKPPSKEGKEEERSLSGHRPPPTAAMNTSSKPPPSSSSSRQTRGLPLRLSTPAAKPLDPRQIQELRDHKAKLEDDARRKKEEESTAWMRRTNYDPDAGEYKRPKSTGSSSSDSPIRRVQTPPEFPENWTAEERANYVRLAREGVKVAVFEQHRLDLEKVEHHEDYMTVVWDGCKNIDIPWHRFKIMPASSAPEETQIQRRIGYNTSGKEIEVMMNAYPITSFPDKAVYQYEINVLHGDQNETDRRILRKCWNSETRKAHIPDGIWDGGRICWSLRNFDDWNEIIDFRSEFTRDVKTLTKNQYKTSPTFRMSVMQKRKINLSVINSWLQNRHDLDQLVIESLSFLDHLLREWPTKQFAAIKRAFFFDKLGDDEELKQEFYQPLANMGASVYRGIYQAIKPTPQGLILNVDVAHCVFFSRISLMGYMMNVNGWNDKSTLVRNLQSTRDEFGGTKESRYFAQVNKRIQGLRVAPNYEGCPFKMKSFIVKGLIHAKPNEFYISYHDKATGTSTRMHLQDYFMKRYNIRLEYPNMLLVEMVKEDVHYPAEFLVIKGLQRYRYKLTDMQAAQMIQWCATRPPKRLANARQSKELLQHKEDPILKLYGMKISDHMIKTKARLLPSPEIQFGGNRKHNPQHAGSWDLRGKKFYKPNEKALQAWGVGFFSGHRKSISHDQTLNWVDQFVKMYKSMGGDVTGRPVVKGLSEDVGMSVKKLYDAIAAQNKSEPQLMVFIVPDKDSWVYLRLKKSSDCRYGTPSQVLQSAHCISNRPQYHANVLMKVNAKLGGVTARAVPKSKSQGLRPGSMIIGADVTHPMMGVWTPSLAAMSVSANSTATRYMGGCETNGDRVEVIRDKVIEYILHPMVAEWKATVGGGKAPEYVYYFRDGVSASEYRRILSEEVPAIRFAIAHACGQPVWAGKMCVVVANKRHHLRAFPDPKNRAAADSHGAPLPGTLIDRDVTSPHDWDFLLYTHIALQGTPRPVHYHVLLDEMGLKPNDLEGMINDHCYQYIRSTTSVSVHPAIYYAHLISVRARHHEDVPITSGPQSGPEVKMTNPKPKEPRAKRLLPIEGTLNRLALGMWYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q2Q9</accession>
    <name>W6Q2Q9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S02g000405</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q2Q9"/>
    <dbReference type="OMA" id="QEILYPR"/>
    <dbReference type="OrthoDB" id="4327467at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM30256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="335" mass="38318" checksum="6C42C967EE796289" modified="2014-04-16" version="1">MAYRPAGLRRPTKPHKPNLHKRGRSHDDDSDSSRSPTRRRLNPKSPESPVLSQGIAEPSASPLLYPIPDDSSTSSNGMTPIAFNSPLGDEKPPLSDDEVCGFHEKGAAYQAWIANPTLGGCHCGQARQTLFDLFNNSNKRERFTCPVNHFDDPPKSIRDDLKNLGLPITNKKYRFTRLFHYGYNKDGDKKETQYQHSFAKGALIAECIYRYTGPHWSNVAIAQYSFDHPIDTLKYIYFTNIVNEETLPYVQEILYPRHDLDWPTRDRLESHAWEYGTEEYRELLGTQLGKAAACVVLGAWERGTRRIARIHTIGREYEIHLRFDIEAIQNNELSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q308</accession>
    <name>W6Q308_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Calcium/calmodulin-dependent/calcium-dependent protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g002400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q308"/>
    <dbReference type="STRING" id="1365484.W6Q308"/>
    <dbReference type="OMA" id="KGDNTHT"/>
    <dbReference type="OrthoDB" id="5979581at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="13"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM28589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="351" mass="39236" checksum="14D82A44C5C48018" modified="2014-04-16" version="1">MYFIRLAPPTARNPLIRAISSLAPGSILQGTYWNYRILNHNHVKGDSTHISDVFKAEVIPHENYHNTPKAPKWAFVKGALPDNATAILNLERERHAYHLPGVSSSQYFRKMYDVIDDSTIALEWLDTTLAELKYQPNDMGTHSLVVAVLRAALTSCAVLEDSKYVNTDYKPANILLSGIGSDCIIAKVGDLGLMVPVGHLRHAQPYAMRAPEVYLGQACAEPSQVRAVAAMFLCWIKPGVLGMWGSYHPFLNEAWSIVKIKRLFPEWDIPTPDEVDGHLIKTVVNCAQSMTETEPKLQDSYLLTRRQKTLEISDQLRDLLRFMLVPDPVKMPSASSVLASRELQAFENLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q3V4</accession>
    <name>W6Q3V4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S01g002610</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q3V4"/>
    <dbReference type="STRING" id="1365484.W6Q3V4"/>
    <dbReference type="OMA" id="YAMYPQN"/>
    <dbReference type="OrthoDB" id="514070at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056722">
        <property type="entry name" value="DUF7820"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42078">
        <property type="entry name" value="GLUCAN 1, 4-ALPHA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42078:SF1">
        <property type="entry name" value="GLUCAN 1, 4-ALPHA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25130">
        <property type="entry name" value="DUF7820"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="343"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7820" evidence="3">
        <location>
            <begin position="398"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="276"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="117"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM28799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="694" mass="74647" checksum="A86CB784B3D432C2" modified="2014-04-16" version="1">MSGHISSEHSRSISQSSQTPQLSSDSTPRRSFGRTSTSNPNVFADEYSLETIDSDRIERPHSPSSIASSSTLRENTQPRAVSTGPTENDNPFADDARVSFDEPHRSSLPQKGYAFANNRNSTSSLNSTPSMIQRNQSVSSRFSIPRALSPYTGATGPSHPYGMYPQVGVSRSPSVGSTSTIRPIERPLEGSTGPQHPYAMYSQNVVEEGMDDDIIPVGFPGHNPPYQPPAGRQADDVGDIIGPDGHAEPLPPYSRYPTGVIPKPPGPETVVDLDPPPEEHRLNNESSRAAPISETSSRALVLEHSGDGNDNGHGEERVAATTGIMAFEEKLKRKGKQTACCGLPVWTLVLIATVMLIGGCIGGVIGGVLGTKKAAEAAKQEHQEAQQSSPLPIITVTATPQMDASMISTPTGLKGVPTGYYTVPSGYQNGSGLCVDESNYGKAWKCMQSPSTIDIFIGESNGHHSIVFDDGVPTPTFTYGAQAPYWSSSPTQALSMAIDTTDIGMGPALFFLAPFDKLVIVPDDTFSNSISKRTFVEDGWANANAYKNLKQTAEIGDKPWFCWWNNTMMEFFLYVNQSTSSSLSTTASINSNMAASTAGSTADAKRDSSATYAYPRRIKMEERRDDPSRESPYCQQMQVRNDGGLALLSGSIINIKENEPTPTTTYTNYKGGTAQTYTAQASYASPCYCVSLTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q420</accession>
    <name>W6Q420_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S02g001493</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q420"/>
    <dbReference type="STRING" id="1365484.W6Q420"/>
    <dbReference type="OMA" id="YHAGQCL"/>
    <dbReference type="OrthoDB" id="429143at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847:SF260">
        <property type="entry name" value="FAD DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847">
        <property type="entry name" value="SARCOSINE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="1">
        <location>
            <begin position="46"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM31343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="462" mass="50553" checksum="F053470C4330650E" modified="2014-04-16" version="1">MLVPNIATSRSLPNPTPCLSYWQRTTRAYPHLYANIDATVPSNSKYVIVGSGISGGLTAFKLIEGGAKAEDIVILEAREAASGASSRNAGHVRPDAFRGFSAYSKVHGEQQALKIIQDERLVLEKVDEFVKKHNVECDFNLTTTFDVCMTPEFAAYEAESLEAFKKAGGDTSHITFYEGEEAQKKTRVPGAVAAYEWPAGSSHPAKLAQFLLQAVISKGAKLFTFCPATEVERSSDTETWKIHTPRGIIEAEKIIHCTNAHAALLLPQLEPYIRPNRAQAHSIVPVPAFSGEKALQSTFSLRYSLLHFYSLIQRKGDGTMVLGVSRSNPTMSAETRAGRFSTDDSRYNEEIAEEALRTFSQMFPAYSSQAAMHGEGLDHVWTGIIGMTTDSVPFVGAVDSLPGQYICAGFNGHGMARIFTCAPTVAQLVLGKTWDETGLPECFQFSEERLARLSNGELPSIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q4I9</accession>
    <name>W6Q4I9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Signal transduction histidine kinase, phosphotransfer (Hpt) domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S01g002900</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q4I9"/>
    <dbReference type="STRING" id="1365484.W6Q4I9"/>
    <dbReference type="OrthoDB" id="1673781at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.160">
        <property type="entry name" value="HPT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036641">
        <property type="entry name" value="HPT_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM29089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="140" mass="15776" checksum="E232F60DB93660A3" modified="2014-04-16" version="1">MTNEQFESNLKRNFDAAIFSQLLEMDHEENRLTSSTTLYAHIAVAITATQEMEKAFLNDDTLLLRSFCDDLRRKSKMLGMYRINESCENIRIASTKMDDGDRAGHCKEEAAFLHTYCALTSLKASVTSARAALDSFYAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q4N8</accession>
    <name>W6Q4N8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S02g001440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q4N8"/>
    <dbReference type="STRING" id="1365484.W6Q4N8"/>
    <dbReference type="OMA" id="KAKDHPY"/>
    <dbReference type="OrthoDB" id="5355007at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038212">
        <property type="entry name" value="TF_EnY2_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="92"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM31290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="162" mass="17242" checksum="CD2E1DC4FF268565" modified="2014-04-16" version="1">MPPSASTNGASSTPDALESDLLVKLSASCALEDLQENLLGSLHRLGWTDKVTTLATELLRAGRCETFDDVMAAVLASAEGRTHPALGAQVANGETTNGTKETNGVRKGNKAKNHSYDPLKYIEEIDIRIPETVVDEGVRGLKDIIREVADLEGESAPNGDKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q561</accession>
    <name>W6Q561_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S02g001919</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q561"/>
    <dbReference type="OMA" id="IHGTHTE"/>
    <dbReference type="OrthoDB" id="203796at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37848">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37848:SF1">
        <property type="entry name" value="SUN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="285"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM31768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="435" mass="49248" checksum="3F4CCA676212358B" modified="2014-04-16" version="1">MGRLQHASSSHSLHSLDDDAPPPYTDDPELIVAPVQPVQHFQPVQPVQPPQSIRPLRLIDSAYYLPGGKDSLSLEPALSSNSDELYNVLRLQIKLPPRPLLSIHGTHTETSNDQKKEKSNTVTDFQFRLDLAETMLTGWEGGYMVTNWREVEVLSDEDLRPAYRGGILRSRTYKPPKSRAAISLTGDSDALLGRDNADEQNNSSPDARNLQMWCERFCSDPASVKSFTLHREVSGFDSNAMQNVLSSHIRELNYRGSLSFGLSISRRSVTIYSPHWINRLRTNRFVWWVVVLLQLWIITWPVIFFMEKRYEVVHTRWNASLIPEDSDSPLAKCYAFGRDESTLAEYWAPAVKQAAWTQRRGDGSILTRMDADRLQGYSTQQLINLRAASSDTETERRERVNRGEAGFVDNVVGLVRGIGEAGRDWRFSAGWGANS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q566</accession>
    <name>W6Q566_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Basic-leucine zipper domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PROQFM164_S02g001276</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q566"/>
    <dbReference type="STRING" id="1365484.W6Q566"/>
    <dbReference type="OMA" id="DDWRLRC"/>
    <dbReference type="OrthoDB" id="2257100at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13044">
        <property type="entry name" value="ACTIVATING TRANSCRIPTION FACTOR ATF 4/5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13044:SF38">
        <property type="entry name" value="BZIP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="8">
        <location>
            <begin position="242"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="58"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="199"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="260"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="66"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="216"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM31126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="309" mass="34177" checksum="6414A26EAD2B42BE" modified="2014-04-16" version="1">MTLTVDPCGAAVHPLVFGFFYMAWPRPSTHFLRTPLLQSWPPIHIHPRVPFRCPPAVVRAPRQRSRPPSTGSNPPYTGTQERHQGPADYSSWANLHPYSDNDLFSSLAPPLEGFPSAVPVCQSVDALTHESALWAEPDLSFADIDWNFVSVDVPTPYLPDHDGGDVPVMDLGYGGLSSFNSLSDSGSIEHQHYISTSLAPSSANSQDGHSHPSPISSLTAPVSTSLSSPSTSQGDDTLTRVDSSRVEKRKLNTLAARRCRQRRVDRMKELEAELEKVRKERDDWRLRCSKLEGETDALKGLLTRRSKDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q6J8</accession>
    <name>W6Q6J8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="9">SWAP/Surp</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PROQFM164_S02g002469</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q6J8"/>
    <dbReference type="STRING" id="1365484.W6Q6J8"/>
    <dbReference type="OMA" id="VKYQEQQ"/>
    <dbReference type="OrthoDB" id="447637at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000381">
        <property type="term" value="P:regulation of alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.790:FF:000002">
        <property type="entry name" value="Splicing factor 3A subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.790:FF:000001">
        <property type="entry name" value="Splicing factor 3a, subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.790">
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045146">
        <property type="entry name" value="SF3A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022030">
        <property type="entry name" value="SF3A1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000061">
        <property type="entry name" value="Surp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035967">
        <property type="entry name" value="SWAP/Surp_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15316">
        <property type="entry name" value="SPLICEOSOME ASSOCIATED PROTEIN 114/SWAP SPLICING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15316:SF1">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12230">
        <property type="entry name" value="PRP21_like_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01805">
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00648">
        <property type="entry name" value="SWAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109905">
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50128">
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        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="SURP motif" evidence="8">
        <location>
            <begin position="34"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="SURP motif" evidence="8">
        <location>
            <begin position="130"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="353"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="460"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="360"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="487"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM32318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2024-10-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q7C7</accession>
    <name>W6Q7C7_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S02g002784</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q7C7"/>
    <dbReference type="STRING" id="1365484.W6Q7C7"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM32633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="50" mass="5299" checksum="3A06A4F2C6C905CE" modified="2014-04-16" version="1">MASSPINVHVASPSVSPNVPSIMQFITTKDHANVRQSNHISPGSFGLILN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q7Y9</accession>
    <name>W6Q7Y9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S02g002656</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1365484.W6Q7Y9"/>
    <dbReference type="OMA" id="ATCEITI"/>
    <dbReference type="OrthoDB" id="4367083at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM32505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="327" mass="37236" checksum="7D1C752E7F5912CA" modified="2014-04-16" version="1">MKEKYAISLGLPISQNATCEITIGSGNQVTTTGTATVPFRLSSENEVHNLEFQLLPNCIHDVIIGKPFLKLTRTFSNVVNFYRRVKKRFAKGISQFHLLYLGASTPMFEGSINGQVQSALADSSSKVLIMDKAYARSIGVHIHTRHEYQTRLKFADNSVTETAGMAYDVEWRFGHDDEFTSPYPLDFHILKNAPANVVLSDSFLFDTKAFPQYCHYLIDDDDDCEDEDVLIYFFLPLILIRERTERKPIYGIWNLVATAKRQTVSLHFQEPRGRLRKPSRTSNALNGTGNSRLCGQKISCRNYNCFLQLLDAIDYVLTFKHLQTSRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q8R5</accession>
    <name>W6Q8R5_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">aldehyde dehydrogenase (NAD(+))</fullName>
            <ecNumber evidence="3">1.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PROQFM164_S02g000774</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>an aldehyde + NAD(+) + H2O = a carboxylate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:16185"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
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    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Ald_DH/histidinol_DH"/>
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        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
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        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
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        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
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        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
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        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
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        <property type="entry name" value="LUC3-like"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="2 6" id="KW-0560">Oxidoreductase</keyword>
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    <feature type="domain" description="Aldehyde dehydrogenase" evidence="7">
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            <begin position="26"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00049194"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM30624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="474" mass="51351" checksum="CBF80CECCBA86B4B" modified="2014-04-16" version="1">MADSTLNFETFFNIVNGESRVSDTTTFSVDPSTESKLWSVPVASKNDVEDAVRSANEAFKSWSTTPFEERVGKLVQWRQLYEPYIEDFTKLLMAECGKPRGVAAGEANEVLALFDHNVQLRIPEERLEDESRIAITRHVPVGVVAAICPWNFPLVLSIGKILPALLTGCTIIVKPSPFTPYSALKFVELAQQILPPGVVQAIGGEDSIGPALVQHPNVNKISFTGSSATGKRIMASAAATLKRVTLELGGNDPAIVYPDVDIEKTAPEVAMGCFVFCGQVCVATKRVYVHESIYEPFLKAMVDAVSQMEVGKADSPSTVLGPMQNKMQYDKVQDLVADTKAQGYKFALAPRAIEGKGYYISPSIVDNPPPTARIVVEEQFGPIVPVLKWSDENDVIARANGTTSGLGASVWSGDASRAEKVAKQMQAGSVFVNSWAKTTPRAMLSGHKESGIGGEWGSTGFLEYCNTQVVHLFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q975</accession>
    <name>W6Q975_PENRF</name>
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        <submittedName>
            <fullName evidence="3">Seed maturation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S02g003375</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="entry name" value="LEA_SMP_dom"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="18"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="SMP" evidence="2">
        <location>
            <begin position="125"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF04927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM33223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="175" mass="18448" checksum="87750EF0179D708D" modified="2014-04-16" version="1">MNFDIPTVAEIQLAAERGQRITQDDVSAISQAESALTGRGPSRGGPAATAQSLCMRQMNFENKVAEISRKPSSAISIEDAEEIQATEGRAFNQPPGVGYISAQIRSIADSNDALGLTAVADVPAYITKDDARDAQHAEASVYGGQNPRGGMAAQMQSAADKIDNARRGSYGSYNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q9M6</accession>
    <name>W6Q9M6_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S02g001044</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="4358066at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="238"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="302"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="165"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="261"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="339"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM30894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="351" mass="39755" checksum="ACAB5C821FC10B0F" modified="2014-04-16" version="1">MEAIGAVSSIFAIYNQLEKCGKRLHRLKHTFQFAKQEVNLLADEVSACKSLFGIFSHISGPLDNRVMKLARQQKLEETLNSQATFAFGQIGEIFLKLGPLRKQSNASRFEQLIAKLRWHWMKDEVQLPLITLASFKMTLTALNCLLILDFRLREMKKPSVSKSEMKSLKMQMKQLRRVINRQERCLRRLSERMSEFSGTSTQPKLVVNTKSMVVTINQIKQNPLSEAQSLINEDILDSSARTSTPSSEKKSSIKSRKTFVSPLSRTRTDISGPSQPGSNSEADAPVGEENVQEILVFHDYGDGNREIHEGGSSISHSSPNEFPDSMKSTYAPMPPFRYSDLRLRKQGKRDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q9V8</accession>
    <name>W6Q9V8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid/polyamine transporter I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PROQFM164_S02g003352</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM33200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q9V8"/>
    <dbReference type="STRING" id="1365484.W6Q9V8"/>
    <dbReference type="OMA" id="WKLKGVA"/>
    <dbReference type="OrthoDB" id="5982228at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000025">
        <property type="entry name" value="High-affinity methionine permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050598">
        <property type="entry name" value="AminoAcid_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785:SF353">
        <property type="entry name" value="METHIONINE TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="94"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="138"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="203"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="289"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="337"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="389"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="418"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="451"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM33200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="499" mass="53896" checksum="D423C17E4417F267" modified="2014-04-16" version="1">MGLPSPVREYTESVPQYETSDSDSLQYTTEVGGNTSKATYQEASGAPVEVNSPLGYSVGWVTVVFLNLSKMIGTGVFSTPSTVLKGAGSVGLTLFYWVIGYLMASSSLSVYMEFASSFPSRSGSEVVYLEQAYPRPKYFFPTVFAMQTVLFSFSSSNAVVLAQYLFKLANSDFTPWKLKGVAVACYTVAVLVLAFHTRWSLRLANAIGLVKLLTLVFIAITGLVVLGGHTSVKDPKANFRSAFEGSNAATAYGATNALTKVWFSFAGYENAFNVVNEVKNPTKTLKWSAPLSLGVTAILYVLANIAYFSAASKEEILESKVVAAGVFFEKVFGTGGAASALNFLICVSAFGNLLAVLLGQSRMLRECGRQGVLPFTSFWTSTRPFGTPLGPYFVKWAFTVLMILAPPAGDAFNFVVDLGVYATTIFGLLLTIGLVIIRARRARLNLPKPEYNAWHVSVAFAILSNLYMVVMPWYPPSTGANGGDVSFWYATYCAVALGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W6QAD2</accession>
    <name>W6QAD2_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Metallophosphoesterase domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S03g000352</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QAD2"/>
    <dbReference type="STRING" id="1365484.W6QAD2"/>
    <dbReference type="OMA" id="GLKEQNH"/>
    <dbReference type="OrthoDB" id="9984693at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033308">
        <property type="entry name" value="PGAP5/Cdc1/Ted1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13315">
        <property type="entry name" value="METALLO PHOSPHOESTERASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13315:SF1">
        <property type="entry name" value="PROTEIN TED1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="527"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM33628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="572" mass="63744" checksum="C15E33D390F11C6D" modified="2014-04-16" version="1">MFLRWLLSRTFALLLPLTVIATVYLYLYPVFNGCAFPLPQSTSRSSEQQLYHNSVINTLLQHLGVSTSDSNSQPAIFRLLVLADPQLEGDTSLPLPEYELYPRIQTHWRAIQEAIGNASTSPLLDEDVLSNITTGLQTLATEDIPRAFKSGLKRIDLFGNDYYLAHIYRTLFWWTRPTHTTVLGDLVGSQWISDDEFARRRHRYWDRVFRGGERVDDNITRTGAAGWSQSEGSNAPPLEPLGADRAWARRVINVAGNHDIGYAGDISEARMERFERAFGRANWDVRFEHPPVLSSSGSAGDQVVTPTLHLINFNSLMFDTPALSTEVQSHTYSYLNELIADRVSPVEDRSAFTLLLTHIPLHKEDGVCTDGPYFSFRDSDDKDGPDGVPRWLNGGLKEQNHLSDTLSASGILQGIFGLSGDENALAGGQGRNGLILTGHDHTGCDTVHFVNRTETVGDDGSPRSWEWAAKRFNESQHIDDPSIREVTLRSMMGEFGGNAGLLSAWFDEVAGEWSYDITMCPAGVQHIWWAVHILVLVTLGVALLLFLSGNAQPKTTTCNVQSDQKTQNRQKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>W6QAM8</accession>
    <name>W6QAM8_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="15 21">Inosine-5'-monophosphate dehydrogenase</fullName>
            <shortName evidence="15">IMP dehydrogenase</shortName>
            <shortName evidence="15">IMPD</shortName>
            <shortName evidence="15">IMPDH</shortName>
            <ecNumber evidence="15 21">1.1.1.205</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="primary">gua1</name>
        <name evidence="23" type="ORF">PROQFM164_S03g000219</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Part of the gene cluster that mediates the biosynthesis of mycophenolic acid (MPA), the first isolated antibiotic natural product in the world. Does not play a role in the biosynthesis of MPA, but is involved in self resistance to MPA, since MPA acts as an inhibitor of IMP dehydrogenases.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 15 21">
            <text>IMP + NAD(+) + H2O = XMP + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11708"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="EC" id="1.1.1.205"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 15">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="15">Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.</text>
    </comment>
    <comment type="pathway">
        <text evidence="15 21">Purine metabolism; XMP biosynthesis via de novo pathway; XMP from IMP: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Homotetramer. Seems to be able to form heterotetramers composed from more than 1 of the 3 IMPDH gene products (IMD2-4).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 15">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15 20">Belongs to the IMPDH/GMPR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.205" evidence="15 21"/>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QAM8"/>
    <dbReference type="STRING" id="1365484.W6QAM8"/>
    <dbReference type="OMA" id="MGYCGAK"/>
    <dbReference type="OrthoDB" id="416622at2759"/>
    <dbReference type="UniPathway" id="UPA00601">
        <property type="reaction ID" value="UER00295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003938">
        <property type="term" value="F:IMP dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006177">
        <property type="term" value="P:GMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006183">
        <property type="term" value="P:GTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04601">
        <property type="entry name" value="CBS_pair_IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00381">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000007">
        <property type="entry name" value="Chromosome 19 SCAF14664, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01964">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005990">
        <property type="entry name" value="IMP_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015875">
        <property type="entry name" value="IMP_DH/GMP_Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001093">
        <property type="entry name" value="IMP_DH_GMPRt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01302">
        <property type="entry name" value="IMP_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11911:SF111">
        <property type="entry name" value="INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11911">
        <property type="entry name" value="INOSINE-5-MONOPHOSPHATE DEHYDROGENASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00478">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000130">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01240">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51412">
        <property type="entry name" value="Inosine monophosphate dehydrogenase (IMPDH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00487">
        <property type="entry name" value="IMP_DH_GMP_RED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 19" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4 15" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 15 21" id="KW-0332">GMP biosynthesis</keyword>
    <keyword evidence="5 15 21" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 15 17" id="KW-0520">NAD</keyword>
    <keyword evidence="9 15 20" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8 15 18" id="KW-0630">Potassium</keyword>
    <keyword evidence="7 15 21" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="22">
        <location>
            <begin position="135"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="22">
        <location>
            <begin position="198"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="active site" description="Thioimidate intermediate" evidence="15 16">
        <location>
            <position position="349"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="15 16">
        <location>
            <position position="460"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15 17">
        <location>
            <begin position="292"/>
            <end position="294"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15 17">
        <location>
            <begin position="342"/>
            <end position="344"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="15 18">
        <location>
            <position position="344"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="15 18">
        <location>
            <position position="346"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="347"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="15 18">
        <location>
            <position position="349"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="382"/>
            <end position="384"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="405"/>
            <end position="406"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="430"/>
            <end position="434"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="472"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="527"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00058020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00062187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU003927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="RuleBase" id="RU003928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="CDM33495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="546" mass="57717" checksum="0942E6855AA842A2" modified="2014-04-16" version="1">MPITAGDAAPGAAMKAEIADYTKAVEVLDTYTTLDGLDADTLLDSDKHGALTYNDFLILPGYIGFPASDVSLDTPVTKRISLKAPLLSSPMDTVTEHNMAIHMALLGGLGVIHHNCSPEDQAEMVRKVKRYENGFILDPVVISPKATVGEVKELKAKWGFGGFPVTENGTLKSKLVGMVTSRDIQFHTGLDEPVTAVMATDLVTAPAGTTLAEANEVLRRSKKGKLPIIDPNGNIVALLSRSDLMKNLHYPLASKLPDSKQLIAAAAIGTREEDKKRLQLLVEAGLDIVILDSSQGNSMYQIEMIKYIKKTIPEVDVIGGNVVTREQAAALIAAGVDGLRIGMGSGSACITQEVMAVGRPQAASVRSVATFAARFGVPCIADGGIQNVGHIVKGLAMGASTIMMGGLLAGTTESPGEYFVSNEGQLVKAYRGMGSIAAMEDKKAGGDGKDSKASNAGTARYFSEKDRVLVAQGVAGSVLDRGSVTKFIPYLIAGVQHSLQDIGVKSLTDMHDGVNKGTVRFEMRSASAMTEGNVHGLHSYDKKLYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W6QAY3</accession>
    <name>W6QAY3_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">TMEM205-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PROQFM164_S03g000557</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QAY3"/>
    <dbReference type="OMA" id="PLTSKTM"/>
    <dbReference type="OrthoDB" id="1641132at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025423">
        <property type="entry name" value="TMEM205-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053009">
        <property type="entry name" value="Xanthocillin_Biosynth-Assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23241:SF106">
        <property type="entry name" value="DUF4149 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23241">
        <property type="entry name" value="LATE EMBRYOGENESIS ABUNDANT PLANTS LEA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13664">
        <property type="entry name" value="DUF4149"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="TMEM205-like" evidence="6">
        <location>
            <begin position="9"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM33833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="172" mass="18920" checksum="1EAA7E830A30746D" modified="2014-04-16" version="1">MDPRPYHVLSYGTLLGTQFFQSFVGGFVAFRALPRPQFANLQTAIFPIYFSLQSALPIVVALTASHGGQVLGLSGLAAPENRLNTLLPLATVTVTGLVNMFVLRPITTNVMRERKHQETRDGKRSYDPAPHSKEMLALNKKFGRVHGISSLVNLISLVATVWYGAVLSKRLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W6QBE1</accession>
    <name>W6QBE1_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="7">AMP-dependent synthetase/ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PROQFM164_S03g000060</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QBE1"/>
    <dbReference type="STRING" id="1365484.W6QBE1"/>
    <dbReference type="OMA" id="CGAPIVY"/>
    <dbReference type="OrthoDB" id="1882297at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000008">
        <property type="entry name" value="2,3-dihydroxybenzoate-AMP ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43859">
        <property type="entry name" value="ACYL-ACTIVATING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43859:SF4">
        <property type="entry name" value="BUTANOATE--COA LIGASE AAE1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="5">
        <location>
            <begin position="39"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="6">
        <location>
            <begin position="480"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM33336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="572" mass="63544" checksum="7A77747BD6239154" modified="2014-04-16" version="1">MSGSKSRLSGLLGHFTGSTPPIEHRVNTHTLSPTFFLPRAAAIEPNAEAIYHVTANNKILRRSYGEAADRARGMAYYLKKHGFKRVGILCPNTPAFLESIFGIAAAGAVNIAVNYRLKQEDIAYIFDHGDAEVIIVDEEFVPLLEHYRSQYPHIHIIIDTDTDVTEGELTGPFDEAVLEGLRHDIDTGSHGWEGLESQAADEDSTIALAYTSGTTARPKGVEFTHRGCYLGTMANIIETGLNYHDGRARYLWTLPMFHAMGWTFPWAVTAVRGTHYCLRKIDYPEIWRLLKEERITHFNAAPTVNTLLCNAKEAEKLPEPVHVTVAASPPTPLLFEQMTDLNLHPVHVYGMTETYGPITKGYHLPEWNELALKEKYQKMARQGHGFITSLPGRVIKTEVPEGTIIDVRKDGKEIGEIVFVGNICARGYYKDSEATRKLFAGGVLHSGDLAVWHPDGAIQILDRAKDIIISGGENISSVALESMLVMHPDILEAGVVSVPDSHWGERPKAFVTVKEGKHMKGSELIEWARNSSGISKFMIPREVEVVPELPKTSTGKIRKNVLRDWVKGAREA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W6QBL4</accession>
    <name>W6QBL4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S03</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S03g000150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QBL4"/>
    <dbReference type="STRING" id="1365484.W6QBL4"/>
    <dbReference type="OMA" id="YEDFFCS"/>
    <dbReference type="OrthoDB" id="3538943at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="300"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="434"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1087"/>
            <end position="1110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1122"/>
            <end position="1174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="341"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="434"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="494"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="558"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="607"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="629"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="660"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="726"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="781"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1087"/>
            <end position="1100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM33426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="1244" mass="136091" checksum="34A2E5B0193112D3" modified="2014-04-16" version="1">MNPVSPWIAALADQCLSFYIGQNDQDEVQVEDIDGCLSFSFCKPTLKTAVVVSWGEGEKSHCATFTDSKNQIDAIILQDSPDVQGATSPCPPSLKGGPRHLVELFDIKLILTYSAPAPDVCLQIKRFTIHPNAVPRGDVPKPKLKKTTALRALMTMACDKIQKTRGHASSNDQTNARLTDPFASQRDRTMPLNHSQTNMASQLLFSQPPSNMRHGAPKSNAMTSRVSLNGSSDLLGLLAPSHPIQTNYAATREVLEAHGLPLGESESRHSPLPNTGIEYVTNQSYADIEKEVVDFIAECTGTQPPNESDDHGPARNVGMGDIQPSKKRHRGSTDVLIHNDGLSSQGRQSSNTPPSKKRQRIDADIGCPSATSPWDGMMKIPLSEVHIPKDQAELLEGLKWIPQDPGISTPLCHVPPRLLTQWNNIARRRQHLAEEAEAEERLSERALTSTPQEPSTSPIPWSPSPDRAPARDVLPRDTASPPRYIRPIRGASPPTGTQYSVDQSIKNGDVDMVNGSCSAPQPGPGDIVSSRNDTRTAEQQCSPSPEEVTTKPRSPLPLDHDPDLPQEHNASKSVDVVNDQPPSITQEHDQSPAKTIPLRSEMRDESSSDESDEPEMETYVPFALGGSLPLSSQPEQEPTSSGPSLPRFAGGTIQVVETPAANNTRLNPGKQSEQRTGVQLPSSQQPYSEATKTSPSSRIPNTYRSQDNHGHSDLSQDEPPLMDVLGTQTQTSSVHALSQATVQSSPDVLDSSRPVQRHRGSSIFRLDPSDNPSSFPDVGSHSLSTSQLHELSQHSPGGLDGGSQLPELSPMEFTTSVAAHGESPSKRPKYSRPPGCEGVDTGQKAAHGPNVELVARRQGSIGNSDEYAEAQTVYEKFCNDYSPYAGGFAHFTEMCSKLQAVRQKGQLQRSFLWDDFVIQYLEEYSRYLTEHIFENSKTLNYEDFFCSRFSRPHHKKRSLTAHGIDIVASQFVPPTSTELRNSPVPNEVTIQGDVTQDKAIQSEVANNSFTASLVGRFSNLHAQSFGDAPVPDVCMPTATQSSSSSYPSTGSDSVVVKIEADDSFNGQIGSQNITSSDDQKPVFFSHDEETTDATRSDAESVRFAPDPNDVDMAEADMDEIEETQEGDGTHHETASIELGDDTDDRRISVSPAPPAPPAALGALNNSEPEQPRRRRPWFRSLRNIWPKGPVWSDDPDTPFKRWARQDQNVLQELNRRGGVRVLTDEKGVIRYPTYNRDQDKNPGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>W6QBQ1</accession>
    <name>W6QBQ1_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">2-(3-amino-3-carboxypropyl)histidine synthase subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">dph2</name>
        <name evidence="9" type="ORF">PROQFM164_S03g000200</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase. Facilitates the reduction of the catalytic iron-sulfur cluster found in the DPH1 subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the DPH1/DPH2 family. DPH2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QBQ1"/>
    <dbReference type="STRING" id="1365484.W6QBQ1"/>
    <dbReference type="OMA" id="QIWNENH"/>
    <dbReference type="OrthoDB" id="449241at2759"/>
    <dbReference type="UniPathway" id="UPA00559"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090560">
        <property type="term" value="F:2-(3-amino-3-carboxypropyl)histidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11860:FF:000001">
        <property type="entry name" value="2-(3-amino-3-carboxypropyl)histidine synthase subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11840">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11860">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010014">
        <property type="entry name" value="DHP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016435">
        <property type="entry name" value="DPH1/DPH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042263">
        <property type="entry name" value="DPH1/DPH2_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042265">
        <property type="entry name" value="DPH1/DPH2_3"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00322">
        <property type="entry name" value="diphth2_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00272">
        <property type="entry name" value="DPH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762:SF2">
        <property type="entry name" value="2-(3-AMINO-3-CARBOXYPROPYL)HISTIDINE SYNTHASE SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762">
        <property type="entry name" value="DIPHTHAMIDE BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01866">
        <property type="entry name" value="Diphthamide_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01121">
        <property type="entry name" value="Diphthamide_biosynthesis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00408">
        <property type="entry name" value="Diphthamide_biosynthesis_famil"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00032">
        <property type="entry name" value="Radical_SAM_3-amino-3-carboxyp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="6 7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="429"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="90"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM33476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="569" mass="62677" checksum="1F6167562BD24574" modified="2014-04-16" version="1">MGSEMKSAPVLSTADDRILEEINLVATRDPTAPVSDDELSITYDIERTLKDIRQARYKRIALQFPDDMLPDAPRVFQLLSRGLEREEVGTNGTQPSNQTDPSNADTDLAHSITELQVEDKTEQHSPRLTILADTSYGTCCVDEVAAEHVDADVVVHYGRSCLSPTARLPVIHVFTHKDLPLEPVIRAFKATYLDPTTKVIIAADVTFSDHVPTVYARLVEEGYSNIYATEVVHEPSSSIPNRTVPESVREAPETLADWQLFHISDPPTALMMTLASRVAAIHIYPTNDLSNENVKPLPASTTAVLRRRYGTLASLTTVPIWGILINTLSVKNYLHIVEHVKERIAKAGKKSYMFVVGKLNAAKVANFSEIGGWVVIGCWESSLVDSKDFWKPVITPFELELALKNDSDRVWTGAWQSDFQAVLDAPAQEVNGNGDDQETSTSTTMSDEDDMSEPESAPPEFDFRTGRYVSHSRPMRDPAPRASQVDGSSTSGPSAARALARRAKGDLAMIGGAFSPGAEYLRSQRTWKGLGSDFDIRYDEEDLDDSTLVKEGRKGIARGYTVGDATDKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W6QBW5</accession>
    <name>W6QBW5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S03</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S03g000917</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QBW5"/>
    <dbReference type="OrthoDB" id="4327458at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM34193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="123" mass="13782" checksum="AE6F916DA9CCF802" modified="2014-04-16" version="1">MKLASSGGRPTLQDEHDAVEFYIAIRDEYDANVAAIVQVKPELPRKADGTLHLTNMRKVSKELGGQVPCEPCKDANDRQGCCREANADRCDNFELFVTSAVEEDEEQDNEEGDEMEEGEEMEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>W6QCC5</accession>
    <name>W6QCC5_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">dynamin GTPase</fullName>
            <ecNumber evidence="3">3.6.5.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">msp1</name>
        <name evidence="21" type="ORF">PROQFM164_S03g000854</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.5" evidence="3"/>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QCC5"/>
    <dbReference type="STRING" id="1365484.W6QCC5"/>
    <dbReference type="OMA" id="PLKMGYV"/>
    <dbReference type="OrthoDB" id="5061070at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061024">
        <property type="term" value="P:membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031623">
        <property type="term" value="P:receptor internalization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08771">
        <property type="entry name" value="DLP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000741">
        <property type="entry name" value="Putative mitochondrial dynamin GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001401">
        <property type="entry name" value="Dynamin_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019762">
        <property type="entry name" value="Dynamin_GTPase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000375">
        <property type="entry name" value="Dynamin_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020850">
        <property type="entry name" value="GED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056495">
        <property type="entry name" value="LIS_MGM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566:SF212">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01031">
        <property type="entry name" value="Dynamin_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24550">
        <property type="entry name" value="LIS_MGM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00053">
        <property type="entry name" value="DYNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00410">
        <property type="entry name" value="G_DYNAMIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51388">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13 17" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="20">
        <location>
            <begin position="238"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="GED" evidence="19">
        <location>
            <begin position="803"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="158"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="896"/>
            <end position="917"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU003932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="CDM34130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="917" mass="101133" checksum="0690BFDAA97BFFDD" modified="2014-04-16" version="1">MSGRILSHRLGPLLRNGQLARHIHNAGSRTGGLLRADGGAALRGRAWPVGANAIHNVPAVRSISFARMLPKLALKLFRIPAMFGGATIAGLAYFQYQATQAGNYVMDVFRQASDTAGNTASTLFQGLQGMADQTQRGWNKTTGNIEMPDWLQKVLRFDEESESRNGDSSGGGGKEPKQSRAGTAAAAAATTAAFGYAQSGEGDLRPERDVAEDDQMMLLTRKMIEIRNILQTIGQSGTLTLPSIVVIGSQSSGKSSVLEAIVGHEFLPKGSNMVTRRPIELTLVNTPNAQAEYGEFPALGLGKITDFSQVQRTLTDLNLAVPEKDCVTDDPIQLTIYSPNVPDLSLIDLPGYIQVAGRDQPPELKQKIVDLCDRYIQPPNVILAISAADVDLANSTALRASRRVDPRGERTIGVITKMDLVSPERGHDVLSDKKYPLRLGYVGVVTRIPQTTALFSRGPGNITSAILKNEHAYFSAHQNEFGPHSDVSVGVSTLRKTLMQVLEQTMSSSLSGTRDAISQELEETTYEFKVQYNDRPLSAESHLAESLDAFKHSFKAFAESFGRPQVREMLKAELDQRVMDILAQRYWNKPVEDLDPPLLELDPLKDLPKADAESLYWHRKLDASTSSLTKLGIGRLATTVVANALNNHVDSLLASSTFASHPGARKQITDACTGILNDKFFSTSDQVENCIKPYKFEIEIEDPEWAKGRDNAGKVLKEELKSCESALKHVEDTVGKRKLQDVVAFIDRVRKGEVVLEGNGEGGAGGFSAALLARGREGLFLRDRADLIKMRLLAVRSKQCATQKNKYYCPEVFLDVVADKLTSTAVLFLNVELLSEFYYNFPRELDSRLGRQLSDAEVERFAREDPRIRRHLDIIRKKELLELALQKIEGIRQLDGRARKSDRTPPGKEPRGRWNLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W6QCT1</accession>
    <name>W6QCT1_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">L-lysine 6-monooxygenase/L-ornithine 5-monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S03g000595</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QCT1"/>
    <dbReference type="OMA" id="KHGRKMN"/>
    <dbReference type="OrthoDB" id="76038at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38663">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38663:SF1">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="94"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM33871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="575" mass="63996" checksum="DCC2E3FFED2CCC5E" modified="2014-04-16" version="1">MSVSQELPEDDEIRDVIIIGAGPCGLAVAARLSEETPSAVFTDEEHQRYHWIKKHSGRMNLVQGRHGKIKGVRAAKWDSERRCPRQEDPRRTSDPASPVPSLSSASSTSSTSSTSSISTLVLDGSGDKWMQRWHNAFRTLEIKQLRSPMFFHVDPGDRDGMLAYTQESGRDADLWEISGCVGKEMSKHKKKKRRQGGQTQTIGAEIDERDRKDYFSPSTDLFSDYCSSIIQRYGLDEPGKILQREATDLSYDYLSDSSTPKLFTVTTSTGEKFYSRSVVLAIGPGGAGVSKIYPWKPSTEQEGAAACCHSTEIKSFPSPNVQNKIQRRQETNVVVVGGGLSSAQIVDMAVRKGVTKVWFLLRSGMKVKHFDITLSWMGKYKNWEKAAFWSADTDEERLEMLQTARNGGSITPRYTKIVKQHAAKNRASIHPCTVIKTHDYNPVTKTWTLTTDPPIPDLPAIDYIYFATGVRADVREMPLLREMNDKYPIEVKSGLPCLTNDLSWRDDVPLFMTGRLASLRLGPGAPNLEGARVGAERVAWGMEEVLHKGRDVGGQCEGFCGLGNRYASLLGECDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W6QD09</accession>
    <name>W6QD09_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Alcohol dehydrogenase superfamily, zinc-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PROQFM164_S03g000675</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QD09"/>
    <dbReference type="STRING" id="1365484.W6QD09"/>
    <dbReference type="OMA" id="GWGEQKF"/>
    <dbReference type="OrthoDB" id="1879366at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05283">
        <property type="entry name" value="CAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047109">
        <property type="entry name" value="CAD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42683">
        <property type="entry name" value="ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="7">
        <location>
            <begin position="33"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="6">
        <location>
            <begin position="191"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM33951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="250" mass="26971" checksum="E5B267CD46B9A500" modified="2014-04-16" version="1">MPYPEEAEGFQVDGPNSFTQFHKRYFKLKPFGDYDVDIKIEACGICGSDVHTISGGWGEQKFPLCVGHEIVGRAIRVGPKVTLIKEGERVGVGAQSYSCGKCKQCLNDNETYCQVEPMDTYGSKWADSGVVSQGGYSSHVRTHEHWVFPIPDALETNKVAPMLCAGLTAYSPLVRNGAGPGKKVGIVGLGGIGHFGVMFAKALGAETWAISRSRAKEADARKLGADGYIATAEEGWEKDHLASILRAICL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W6QDZ4</accession>
    <name>W6QDZ4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Universal stress protein A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S01g001603</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QDZ4"/>
    <dbReference type="STRING" id="1365484.W6QDZ4"/>
    <dbReference type="OrthoDB" id="843225at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23659">
        <property type="entry name" value="USP_At3g01520-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47815">
        <property type="entry name" value="UNIVERSAL STRESS PROTEIN A FAMILY PROTEIN C25B2.10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47815:SF1">
        <property type="entry name" value="UNIVERSAL STRESS PROTEIN A FAMILY PROTEIN C25B2.10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UspA" evidence="2">
        <location>
            <begin position="138"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="276"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="343"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="384"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="315"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="347"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="387"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="410"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM27792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="469" mass="51356" checksum="0174923D8322D3FB" modified="2014-04-16" version="1">MSAPTSPTVSSESVERPELGDHTISAGSGHTRGLSSEDKPKNQRRSIQFSIAEAQLPSRPSSFKEKRLSYGDTPSRELLEEKEREHKAAQLNRGPSPPPPKTYERGVSFDTFDNFDATDFSLTLNYKHKGYQCTRRSRTFLCGTDQNDYSEFALEWLIDELVDDGDEIVCLRAVEKDSSIASDAGIEERKYREEAEKLFEQVIRKNSQNEKAISLVLELAVGKVESILQRMIRIYEPAMLVVGTRGRNLKGVHSLLPGSVSKYCLQQSPIPVIVVRPSTKREKKKKKRRADPTRRSYNHILEMSEQRGSQIFGASASNDSSTSKLPDEEAAVAEALGLPASYSNTASRSSLSVSDRSSVSHDDSDSTYPIRNSLDAVVMASPGVASSADSSQESVIAGSSAQPSPLLESTVASPTPSDQLESPVPDPAPEADKPEEDEPSDSSKNPVSIPMIEVSENNDEDDNKKGSES</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W6QE80</accession>
    <name>W6QE80_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S02g002660</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QE80"/>
    <dbReference type="STRING" id="1365484.W6QE80"/>
    <dbReference type="OMA" id="METGESH"/>
    <dbReference type="OrthoDB" id="5086500at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF6">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM32509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="484" mass="56003" checksum="689D13300336F83C" modified="2014-04-16" version="1">MGGLEATEVSGKHFLSQARKNWLLIIDNADKPDLKFENFIVPRERGHILVTTRNPSLQRQGNVGSMEVKGLKQRDALHLLMKVVDIIPPWDLSSETAANEIIKTLGYLALTVIQAGNSIYNKIYNLSEYLGFYRRFLKNRQRRKSVSNTEDIIGGKVENNDIYSAFDFSFQHIVSNNTIPSQDTVEILNIVSFYHFDNIRVNIFERGMSLKRSQLRQYLTRPLREGFVQAIISRFRPPRALPRILKQSADDMHPLYIREALRELYSSSLITYENDEQSFSLHPLVHAWARDRIPPMEKSLWAIISFHTLMASIPLPPMETGESHTIFRRSLIPHLNECLEAYPIEFREFSRLHIGKYRRFTLLFQPTLLFSIQEMIQNAAKCGILHAEKGDFSKSVYYLFLAKESLVTLLGPNDAKIINTILGLASILWDLGHLKEAIALQEQVVESQQRFLGPDYRKTLLAMDSLSHYFWLNRQYYKALQLQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W6QEB6</accession>
    <name>W6QEB6_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S03</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S03g001532</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QEB6"/>
    <dbReference type="OrthoDB" id="76567at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM34805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="176" mass="19568" checksum="64B7B09519D02E39" modified="2014-04-16" version="1">MSALPADPIEGTKGLIKVVLSERHDAVTNQFGRATDRKLIAMGLRWLEIVNREAMRSYHQIAAPMGVSKSLPRLREDAKRWLIIPRGLVRIVIIISMGLTEVTFEKCQLAPLTLAIRAIPTQQPYSVQEVYVQSNNVVGAPSSLPFVAIYDRPPGPGEHDIVLNANDSLEITRMLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2024-10-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>W6QED8</accession>
    <name>W6QED8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S02g002720</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QED8"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM32569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="70" mass="7864" checksum="66D64A1458ED084B" modified="2014-04-16" version="1">MVSQNIIRSVLVVLEQQVSSIESSTLLDYPNIPTTISAVSLVGTFLLKSTYLGSLYILFADYLCVVTWYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W6QET8</accession>
    <name>W6QET8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S02g002870</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QET8"/>
    <dbReference type="OMA" id="HRDIEAP"/>
    <dbReference type="OrthoDB" id="4280445at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM32719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="124" mass="13474" checksum="0B16EDBB1CF42ED5" modified="2014-04-16" version="1">MQLSLSLIGSDEVGQFLFHHQNPNVVARDAKALGKLVKLGEDHRDIEAPSELVEFMSQEGHGVVIGDSEGVARFGNEGIVMYEVFRVVRIRGDYPVKGRSRVSFGQPGTLAVPRSSVVVVVDEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W6QF01</accession>
    <name>W6QF01_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Carboxylesterase, type B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PROQFM164_S03g001365</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QF01"/>
    <dbReference type="STRING" id="1365484.W6QF01"/>
    <dbReference type="OMA" id="WHYVPSR"/>
    <dbReference type="OrthoDB" id="3358017at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF27">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01030)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="84"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="119"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="197"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="235"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="6">
        <location>
            <begin position="273"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM34641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="425" mass="48230" checksum="13EFDBF9D7FF7C00" modified="2014-04-16" version="1">MPELQTYKGYYLWHYVPSRAAAVIFLLLFLAATAYHTWKIWKLKTYFCICFAIGGFFEFIGYCARTSAYDKTGRMMPFCIQNVFILLGPALFAASIYMVLGRIITAVKGERHSLIPVRWLTKLFVTGDVLSFLIQGGAAGMMISSDLASIGNKLVILGLIVQVAFLGFFIVSMVMFQVRIHRHPTHEVFSEDLRWKWHLNTLYLVSLLIMVRSIFRVAEYIMGNDGYLLQNEWPAYVFDATLMWIVMVTFGVRFPSEVYACSHVPGRVNLNEMGAMHSDSHYSFSNIRYAAPPVGNLRWKAPMLPLTNRSVIQSNPESISCPYGISSWQLRTLQYINEYLKTGNFPNVSYSDLSAISAGGEEDCLFSDVQVPRKIFNNCQKNRRLLPVLVWIHGAFGFLSGPSFEVEGGVLNAGLYDQRLALQWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W6QF85</accession>
    <name>W6QF85_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S04</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S04g000319</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QF85"/>
    <dbReference type="STRING" id="1365484.W6QF85"/>
    <dbReference type="OMA" id="SVRFMNN"/>
    <dbReference type="OrthoDB" id="2142040at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34706:SF2">
        <property type="entry name" value="RFEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34706">
        <property type="entry name" value="SLR1338 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="390"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="24"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="104"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="391"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="440"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM35438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="496" mass="52442" checksum="D958170C39B9239B" modified="2014-04-16" version="1">MGFAQKIAAAQNNEKMANSGSYGGAPPAGYTGGPPAALQSGGSSQQPQYQAYSGSPAPQGSNQAAPYSSQGAPYPGGQGRPGPAPGPPGGPPPGQYGAPGGGPQAAAPPATQQQAAAYRSLLISTIQERNLQSFYPPERLDRLVQSLAAEAPAKLNRLIQEWAVPMEVATDVMKLSLFDVILYVDDSGSIEFEEKGLRKDQLRQILGIVATAASTFDQDGISVRFMNSSEVGDGIRDAEDVSRLVSRVRFSGLTPLGTSLKSKVIDPMVVQPARANRLEKPVLVITITDGQPAGEPHGTVGDVIRYAVEETSRTRYGPGAVSFQFSQVGTDQRARDFLGSLDQDPHIGHLIDCTSNFEVEQDEMSRANPPVHLTRELWCAKLMLGAIDSSYDTKDERDNERRGAPPPASISQYGGGPYGQPPPPQGQAQPSYGPPPGAPPASYGSQSGYPPQGGQYQQQPPQQAPQQGTRGAYGQQPQYGSQPGPGYQYGGQPPRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W6QFM4</accession>
    <name>W6QFM4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nucleoside phosphorylase domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S02g003130</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QFM4"/>
    <dbReference type="STRING" id="1365484.W6QFM4"/>
    <dbReference type="OMA" id="FRWASCQ"/>
    <dbReference type="OrthoDB" id="1577640at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054471">
        <property type="entry name" value="GPIID_WHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF11">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22939">
        <property type="entry name" value="WHD_GPIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="NACHT" evidence="3">
        <location>
            <begin position="447"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM32979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="814" mass="90910" checksum="4B07BF6AB7353CDA" modified="2014-04-16" version="1">MAESSQSQPEQSVSGQDKPGPDRPPCQKRLQHDAYTIGWVCALPKEQTAARAMLDEEHEPLPIPRNDHNSYTLGSIRGHNVVIACLPSMGTNPAATVATSMINTFQSIRFGLMVGVGGGIPPKVNLGDVVVSQPVADYHGVIQWDMGKLERDGRFVHTGSLNRPPNALLNASNQLKSNHEMYGSQINEYLIDMERKFPRLAPKYTRCKCLQDPLLVSESSWSPREVYFLSWLWEPIIAIIAYLLGSWAIDLVNEENVRLSDRADGARAPREVRVHHGLIASGNKVIKDAKSRDLLDKKYGGHLLCVEMEAAGLMNDFPCIVIRGICDYADSGKEKTWQEYAAAVAAGYAKELLGCVQPSVVDAEDSAKAILEKVHQGIESVQRTTAATRATTDSIRSDLHTDKIKRWLCAPDPSSNISHARTLRHEGTGEWLLESPGFQAWRSGSRRHLWLHGLAGCGKSVLSATVLDNLTNGNDGLILSFFFDFSDAAKQTLEGMLRSLAFQLYDSGLDSANHLDTSFQTHRDGSEQPTTKVLWGVVFKMLVAQKKVSIVLDALDESRTREAVLKWIKDMVLSPELVHVQLLLTGRPESEFLRDIPPLIGRQNCLPLDKQAVNSDIRSWVTAQLSQRSDFIQKPLSQKLLEEIRKKVGDGADGMFRWAFCQLDSLGQCPYEEAIEEALESLPQDLDKTYERMFESIPTKLKSDAIRLLQFLVHSKRPLTLAEVKEVIATKIENDSQGFYKKRRLFCENEILAYCPSLVTVVHTDVEELYLAHFSVKEYLLENDCFKTVAASISITRTCLAYLTDINGSEREMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W6QFV0</accession>
    <name>W6QFV0_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Fatty acyl-CoA reductase</fullName>
            <ecNumber evidence="1">1.2.1.84</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S02g003220</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a long-chain fatty acyl-CoA + 2 NADPH + 2 H(+) = a long-chain primary fatty alcohol + 2 NADP(+) + CoA</text>
            <dbReference type="Rhea" id="RHEA:52716"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:77396"/>
            <dbReference type="ChEBI" id="CHEBI:83139"/>
            <dbReference type="EC" id="1.2.1.84"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the fatty acyl-CoA reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.84" evidence="1"/>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM33069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QFV0"/>
    <dbReference type="STRING" id="1365484.W6QFV0"/>
    <dbReference type="OMA" id="CNEIPVD"/>
    <dbReference type="OrthoDB" id="429813at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102965">
        <property type="term" value="F:alcohol-forming long-chain fatty acyl-CoA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080019">
        <property type="term" value="F:alcohol-forming very long-chain fatty acyl-CoA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035336">
        <property type="term" value="P:long-chain fatty-acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026055">
        <property type="entry name" value="FAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11011:SF45">
        <property type="entry name" value="FATTY ACYL-COA REDUCTASE CG8306-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11011">
        <property type="entry name" value="MALE STERILITY PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="1" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioester reductase (TE)" evidence="2">
        <location>
            <begin position="13"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM33069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="405" mass="44394" checksum="BAA9EF6FE98C0091" modified="2014-04-16" version="1">MDSEWFRGQVVFVTGATGNLGGCLLYKLAIQLPTAKIFVLVRGSVQKAIEAWEQSMPEQVEDVIATCKIQFFLGDMTRPNLGLSPANLSRLRNEVTVVINTAGDIALSRDLAETIPVNCTAHLTLAALLDSFTQLQRFLHISTTYVSSFLPDGVVKEQIYPLYEDPAEELEKILSTGKSSYTKQFAAPYALAKHLAECLLLGGDHKFPILIVRPCLISPAIAEPYPLYGSDGAIPVHSFLQILLGDAEYGPLKLEQTLPFHAACNEIPVDLVARTCLAHVAQGTTGVVHASADLYVSRSIGDLLERMRRHAPEGAADQVQKAGIDHGEVTAPEFYTMIQQFARDWKIECTRSAHLQQVVGPLGLDLGDHDPEIFFKLRIERLAKTLLEKLESASVASNKVYPSIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>W6QG35</accession>
    <name>W6QG35_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Beta-ketoacyl synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PROQFM164_S01g002428</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1365484.W6QG35"/>
    <dbReference type="OMA" id="FAGAMFH"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901336">
        <property type="term" value="P:lactone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05195">
        <property type="entry name" value="enoyl_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000209">
        <property type="entry name" value="Polyketide synthase Pks12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056501">
        <property type="entry name" value="NAD-bd_HRPKS_sdrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049552">
        <property type="entry name" value="PKS_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF29">
        <property type="entry name" value="ASPERFURANONE POLYKETIDE SYNTHASE AFOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23297">
        <property type="entry name" value="ACP_SdgA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13602">
        <property type="entry name" value="ADH_zinc_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23114">
        <property type="entry name" value="NAD-bd_HRPKS_sdrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21089">
        <property type="entry name" value="PKS_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="9">
        <location>
            <begin position="28"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="10">
        <location>
            <begin position="955"/>
            <end position="1273"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="8">
        <location>
            <begin position="2459"/>
            <end position="2536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="6">
        <location>
            <begin position="955"/>
            <end position="1092"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="6">
        <location>
            <begin position="1114"/>
            <end position="1273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="2426"/>
            <end position="2448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="2431"/>
            <end position="2442"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="6">
        <location>
            <position position="987"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="6">
        <location>
            <position position="1180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDM28617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="2542" mass="275767" checksum="C2E43EB579850771" modified="2014-04-16" version="1">MIIPVSPTPSPSDGDTDHSLAPELDLPVMPIAVIGMACRFPGDATSPEKLWELCANARSAWSPIPSNRFNQAAWYHPDKEHLGTSYVKGAHFLTQDASQFDASFFNLSSETASAMDPEVRMQLETVYEALENAGIPLEQVAGSRTAVFAGTCFRDNHDSLMRDPDTLARFYLTGNGAAMIANRVSHFYDLRGPSLMIDTGCSTTLTLLHLACQSLRANESNMAIVGGSNVLLNPDMFISGTNLSLLSAEGKCFAFDSRASGYGRGDGVATILIKPLETALRDGDPIRAVIRNTAANQDGKTATLTSPSQEAQQTLMRECYEVAALNPVDTAYVEAHGTGTQAGDTIEAHALGTVFGNGRPGEHPLLIGSVKTNIGHTEAASGLAGIIKAVMALEKGKIPPHLNYESPNEKISLETLKLKIPLSLQSWPSHSLRRASINNFGYGGANAHAILEHPQYLLPLLAPSTELCSPNPKARSRVFVLSAKDQQTTRTMVDQLRQYVSEAGERSEPKNDHLMDQLALTLGQRRSRFAWTVACQADSLAALQSTLDSTQLSPHRSSRAPRLGMIFTGQGAQWHAMGRELLSAYPVFWQTIGEVDECLRSMGASWSVVEELQRDANESRVNQVSHSLPLSVAVQIALVNLLRSWGIHPTGVTGHSSGEVGAAYAAGAISLSAAMAIVYSRGDLTSQFQRLLDRAGGMVAVGLGRENAQAVLSRVQSGKAVIACVNSPSSVTISGDMIAIEEIEAILAQEQVFARRLKVEAAYHSHHMLPIADDYREMLSRFLQPEPGYDGGITYSSPTTGDRMYSGEEIASPEHWVRNMVQPVEFLDALRNLCVNPAETDGTPAVDLLIEVGPHGALAGPVRQTLQLPELQPAGIAYESCLTRGENAVQTMHRLVSSLVKQGYPVDLGAVNFPYSHQGIPMLTDLPTYPWNHETSYWTEPRMNRDLRTRTFAPHDLLGVAAADSTPSTPSWRYVIRPRDVPWVRDHVVQGSIIYPGAGYISMVVEGLRQLGGGEFSLTPSGYQLQDVQIRNPLILDDTSAAGVEVRTSMRPTADGVLRVQGWYDFQIQSVDTQGKWTIHCEGQCATIAPHNGSGWVGPAFVDSGIDNQAEQGNWRTIDPADTYKALHAVGVNHGPIFQNLIAAQSMPGHSISTFKVADTADSMPHRHQQPHLIQPTTLDSVFQGVYHNLPSGGTDQRTALIPTAIKSLYIASSLSAEPGHIFESHSSLIRSGPHGFESSVRLVDATTPGPHREPVLRIEGLFFRSLGGTATIDEPHDNLCYQAIWKPDVDFVTAADLRPSQASNLGAKQLKFSRLQEMAVVFLSAVLREIKEETVTADNQAYWTWMKSVVDEARPTLDLDGMSAEYVLALASDLEEVEEGRLLTRFARALPDILSGQTDARIVAEHCHFELLERSSSQPADFCVSVVQDLLGLYSYKSPQSKILEISNGSFQTTRMILDALTAGTDRGFSDYDMATLELQEARATTDEDALKDYDGRVHFKTYTPSEFPEDQGFSPETYDLIILSSALCITGDVEQILKNVRTLLKPGGKCLIFGHSIQDSAIQVILRLMPQWKGVASLESWKGPLERAGLDPCALQVVQGLDAESYRGEVILASILPPEVAKELPSSRQIMLVYSTAAPPESWVQSLRATLHQHGSYSLSVHSLEEAVNVESGVCVFLDDLVSPLLHNLTQDQFNALRHLLGFSQGSLWVSRGAQAITEEPWGALHQGLLRTLRCENTAKRYVSLDLAPESAAWSAHSADVVARILHVGFYLSPHNKLETEYSVRSNVVHISRVCENVHETQLVSGLSLRREPELKPFFEIGHPVRLGVTTPGLLSSLEFGHDPLANEPLPDGYVEIEPRAFGLNFRDVMVALGQLDEIRMGFECSGVIAHVTPQARAAGFREGDYVYAFIIGYFATRVRIPYTSVAPIPVGMDFPTAASVPLVFITAYHALYDLAHLKPGETVLIHSGTGGVGQAAIMLAQAAGAEIFVTVGSEEKRDFIAEHYGISPSRIFSSRNDSFVDHIMHATNGKGVDVVLNSLAGPLLRQTWRCIGTFGRFIEIGKKDIEQNSMVEMGPFVRSVLFASLDLITLGEQRGPEVARIFGEINTLLEAGQIRPVSPITTFSMGEVEKAFRTMQTGKHIGKIILQPRPGDIVKVLPPAPKPIILSPKASYLVVGGLGGIGKSVAQMLVDRGARHLVLLSRSASTLDHSRKAFVRSLEAHGTTVTLHSCDIADKSQLMAVFADCARRMLPVKGVIQAAMVLKDCIFEQMKWADYMAALRPKVQGSWNLHELLLDADFFVLLSSISGFGGNAGQANYAAGGSFQDALARHRAAQGLSAVSIDLGMVSSVGVVAGTQRVADHLTKLGLRAVSEQEVLGLVESAIRDPRRTSTTCQVVTGIPSTFTRSDSAAFWNHDTRFAGLEQRGDLTGSGEGSAGPDGSGPNIKKQLTASTTLLEAVQTITHALVGILAGMFSRPVSEIDPNMSLSQFGVDSLVAVELRNWLVATFEAECSLFDVMHSSSVTALATLVAHKSKLVCVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W6QG45</accession>
    <name>W6QG45_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CST complex subunit STN1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Suppressor of cdc thirteen homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PROQFM164_S04g000261</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QG45"/>
    <dbReference type="STRING" id="1365484.W6QG45"/>
    <dbReference type="OMA" id="FCFKASP"/>
    <dbReference type="OrthoDB" id="77828at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040260">
        <property type="entry name" value="RFA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018856">
        <property type="entry name" value="Stn1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13989:SF33">
        <property type="entry name" value="CST COMPLEX SUBUNIT STN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13989">
        <property type="entry name" value="REPLICATION PROTEIN A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10451">
        <property type="entry name" value="Stn1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0779">Telomere</keyword>
    <feature type="domain" description="CST complex subunit Stn1 N-terminal" evidence="11">
        <location>
            <begin position="46"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="238"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="94"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF10451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDM35380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="283" mass="32650" checksum="9427DAC61E8E17DE" modified="2014-04-16" version="1">MTIVNHENLVFYPAFCFKASPTHFTWVKMGAADVHRLRKSSDFVGQNIFFYNNHPIQFVSLVGIIVARTDVPRRTILILDDSSGATIEIAVLKQTSPNPGTTSQETPATGPGKPAWSSFSLTAPTATSLTQTTHVTSKDHNKIDISALQPGTLVRVKGTLSTFRSQMQLHLERFWLVRDTNAEMQFLDTRLRFLIEVLSVPWVLTDEEVETLRDDAERCDERTLEHKRRAERVARKRVEREERHARAIALQYEKEERERERELKKIREDGERVMRKFGFERSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W6QGF6</accession>
    <name>W6QGF6_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Amine oxidase</fullName>
            <ecNumber evidence="15">1.4.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">PROQFM164_S04g000784</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a primary methyl amine + O2 + H2O = an aldehyde + H2O2 + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:16153"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:228804"/>
            <dbReference type="EC" id="1.4.3.21"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>L-topaquinone</name>
            <dbReference type="ChEBI" id="CHEBI:79027"/>
        </cofactor>
        <cofactor evidence="15">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
        <text evidence="15">Contains 1 topaquinone per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>L-topaquinone</name>
            <dbReference type="ChEBI" id="CHEBI:79027"/>
        </cofactor>
        <text evidence="14">Contains 1 topaquinone per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="PTM">
        <text evidence="14 15">Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the copper/topaquinone oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.-" evidence="15"/>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QGF6"/>
    <dbReference type="STRING" id="1365484.W6QGF6"/>
    <dbReference type="OMA" id="VHVGFNY"/>
    <dbReference type="OrthoDB" id="5379943at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008131">
        <property type="term" value="F:primary methylamine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009308">
        <property type="term" value="P:amine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.98.20:FF:000001">
        <property type="entry name" value="Amine oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.40:FF:000019">
        <property type="entry name" value="Amine oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.40:FF:000014">
        <property type="entry name" value="Peroxisomal primary amine oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.20">
        <property type="entry name" value="Copper amine oxidase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049947">
        <property type="entry name" value="Cu_Am_Ox_Cu-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049948">
        <property type="entry name" value="Cu_Am_ox_TPQ-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000269">
        <property type="entry name" value="Cu_amine_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015798">
        <property type="entry name" value="Cu_amine_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036460">
        <property type="entry name" value="Cu_amine_oxidase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016182">
        <property type="entry name" value="Cu_amine_oxidase_N-reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015800">
        <property type="entry name" value="Cu_amine_oxidase_N2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015802">
        <property type="entry name" value="Cu_amine_oxidase_N3"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008559">
        <property type="entry name" value="PRK11504.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638">
        <property type="entry name" value="COPPER AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638:SF86">
        <property type="entry name" value="COPPER AMINE OXIDASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01179">
        <property type="entry name" value="Cu_amine_oxid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02727">
        <property type="entry name" value="Cu_amine_oxidN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02728">
        <property type="entry name" value="Cu_amine_oxidN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49998">
        <property type="entry name" value="Amine oxidase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54416">
        <property type="entry name" value="Amine oxidase N-terminal region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01164">
        <property type="entry name" value="COPPER_AMINE_OXID_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01165">
        <property type="entry name" value="COPPER_AMINE_OXID_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 15" id="KW-0186">Copper</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="6 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13 15" id="KW-0801">TPQ</keyword>
    <feature type="domain" description="Copper amine oxidase N2-terminal" evidence="17">
        <location>
            <begin position="21"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="Copper amine oxidase N3-terminal" evidence="18">
        <location>
            <begin position="111"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="Copper amine oxidase catalytic" evidence="16">
        <location>
            <begin position="238"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="13">
        <location>
            <position position="315"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via topaquinone" evidence="13">
        <location>
            <position position="399"/>
        </location>
    </feature>
    <feature type="modified residue" description="2',4',5'-topaquinone" evidence="14">
        <location>
            <position position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR600269-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR600269-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CDM35903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="683" mass="76444" checksum="C7E9292F1F97F1F4" modified="2014-04-16" version="1">MVLDRLHQLTHQVSATAPPPHPLDPLSTVEIDAAVNIVRKEHGSLNFNAVTLYEPRKAQMMAWVADPENAPRPSRAADIVAIAPGGKIYDGVVDLDQKKIIKWQHTPNVQPLITMEDLQEVEHVVRKDAKVIEQCGIIGIPKEDMHKVYCDPWTIGYDERFGTGVRLQQALMYYRPHPDDSQYTYPLDFCPIFNAETKQIIHIDVPSVRRPLSKAPPNNYHPASIEKEGGYRTDLKPIHITQPEGVSFEVKGRIIEWQNWNIHVGFNYREGIVLNNITFNDKGNVRPVFWRLSMAEMVVPYGNPEHPHQRKHAFDLGEYGGGYMTNSLTLGCDCKGAIHYMDAAFVNRAGASTIIKNAICIHEEDAGILFKHTDFRDESMVVTRGRKLIISQIFTAANYEYCVYWIFHQDGTIQLEIKLTGILNTYAMNPGEDTKGWGTEVYPGVNAHNHQHLFCLRVDPNIDGPNNTVFQVDAVQGPGEVGSAENKYGNAFYAKKTKFSTPIEAMSDYNGSTSRSWDMANTNKLNPYSKKPVSYKLVSRDVPPLLPKAGSLVWKRAGFARHAVHVTKYDDDQVHPAGRHVPQTSGEPSEGLPAWIEAAGPSCSIDNTDVVLWHTFGLTHFPAPEDYPIMPAEPMTLLLRPRHFFDRNPVLDVPPSFARTPTQVAANASTCACKKNDGSSVLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W6QGK7</accession>
    <name>W6QGK7_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Alcohol dehydrogenase superfamily, zinc-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PROQFM164_S04g000844</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QGK7"/>
    <dbReference type="STRING" id="1365484.W6QGK7"/>
    <dbReference type="OMA" id="GHIMGHE"/>
    <dbReference type="OrthoDB" id="442947at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08284">
        <property type="entry name" value="FDH_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42813:SF2">
        <property type="entry name" value="DEHYDROGENASE, ZINC-CONTAINING, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G02810)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42813">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="7">
        <location>
            <begin position="27"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="6">
        <location>
            <begin position="198"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM35963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="365" mass="40206" checksum="0DB88F29DDCBD024" modified="2014-04-16" version="1">MSMKAVVFRGPFDIRVEQKPRPRIQDDTDAIIRVTLAGICGSELHMYRGHQQTATGHIMGHEFVGIVEETGKDVALFHPGDEIVSIFSPVCLKCWFCLQGLTNRCVNGVAFGTSLLNGGQAEYVRVPFADGTLQHVPAKLDRRLLIMMSDIFPTGYYGAQRAIEGLRTQYNSRLTSFNLKTANEKLHESTVVILGCGPVGICAIAAARSEGIKTVFAIDSVKDRLDEAEQFGAIPLMLGEDDINARVLEATDNRGADAVVEVVGNKPALRSAFDLLRPCGVLSSVGFHQGELPFTGLECYQKNITVNFGRVPVRTVFEDALQCLTENQEKMQSYITHELPLDDAAKGYDIFEQRKARKVILNISK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W6QH46</accession>
    <name>W6QH46_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Major facilitator superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PROQFM164_S04g001034</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM36153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QH46"/>
    <dbReference type="OMA" id="LLWFIWM"/>
    <dbReference type="OrthoDB" id="4139357at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17316">
        <property type="entry name" value="MFS_SV2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000171">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511">
        <property type="entry name" value="SYNAPTIC VESICLE GLYCOPROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511:SF12">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G01740)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="174"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="216"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="317"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="364"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="391"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="416"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="450"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="478"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="53"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDM36153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="507" mass="54862" checksum="1748E21015E8DDEA" modified="2014-04-16" version="1">MPEVTKLPGLEPTAIEGPAVPQNEGPDANYKAKAEVLNQAIQTIGMGRYQWQLFVVIGFGWASDNLWPIVTSLILPAVSNEFHPSKAPLLTLAQNIGLLVGAVFWGFGCDVFGRRWAFNLTIGITAVFGLVAAGSPNFAAVCTFAALWSVGVGGNLPVDSAIFLEFLPGSHQYLLTILSIDWALAQVVATLIGWPLLGYRTCGSAEGCTKAENMGWRWFIIAMGGIAMIMFVGRFVFFTVFESPKYLMGKGRNEQAVEVVHEVARRNGKVSDLSRTDLDAWDQGEIQNFSAANIVRQRLETVRFDHLRALFDTPKRAWATISIILVWAFIGLGFPLYNAFLPYIQQSRGAEFGDGSTYITYRNSLIIAVMGIPGCLLGGVLVELPRFGRKGALSSSTAVTGAFLLASTTATTSNALLGWNCAFNFMSSLMYAVLYAYTPEIFLTKDRGTGNALTASANRIFGIMAPIIAMFADLTTAAPVYVSGALFLAAGILVLFMPYESRGKASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>W6QHC8</accession>
    <name>W6QHC8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type DNA-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PROQFM164_S04g000701</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QHC8"/>
    <dbReference type="STRING" id="1365484.W6QHC8"/>
    <dbReference type="OMA" id="RMKIWWS"/>
    <dbReference type="OrthoDB" id="3034343at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001080">
        <property type="term" value="P:nitrogen catabolite activation of transcription from RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050797">
        <property type="entry name" value="Carb_Metab_Trans_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668:SF10">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="16"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="47"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="53"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM35820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="624" mass="70191" checksum="511C60EAA60924E7" modified="2014-04-16" version="1">MESGDERPYRSHTKPACVPCRRRKSRCKLEPHTAACLMCRAHGTECTFPNGRGKSTPQKRYSTEDSPIQPHPNLRTPAVATRPLNRLPPPVATSPQFSIVTQARNEQDTPLSLEADDDNPHILGPAVTGDNHVLADYLSNISGGQGIREIRPVEPGSSSSPVIFTKVQKRPLGLMVNSSPALHKLQTIEKLVEPWGPHLIDIYLRKINPCIPLLEESSFRAQYTNARHRISPALLACLYAHVLTQWQHDPLLSRERCPDIRFVWNLAIEASYSELHASAGISTIKAILLDVGGRPTTSMTGNGVRLGSAVALCHSLGLNRNPLPWDIPQEEKHMRMKIWWSILLHDRWSSLAYGTPPHIRRSQYDVPLPKSEYLSDWERDHEANAVFIELMNLTDVLDHCLEQVYSIRIETQAPSRNLELELNKWVDSLTGDIRKIIIRGSNLNIPGSSNLRLAYLATRLLLRRIDLDRERQAPDSNAEHMANQIMEARRTAEDIVVLVQELGEAQLGDFWLPVVAFTFSATVTFLIRCALDTEQAAGLAQSGSLRMANDLLDSLRSHHKNFGWDLGDICLAQHSDVIDKLLKSEPPLENSGETNLDLRQPFMPDMTFVDDMFPSTWDILQIME</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W6QHG1</accession>
    <name>W6QHG1_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S04</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S04g000297</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004879611" evidence="1">
        <location>
            <begin position="20"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM35416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="124" mass="12884" checksum="3D74B81F05CEB135" modified="2014-04-16" version="1">MHLWKALILTYAHLALSQAAACSAGGCGSAPACVLTETCTTATFVSPSTTTITTCVPTPTCAGVYSSCEFGTPNNQCCSGYCAANKCRSTDDRWPSCSEDNGPCVVDEHCCYGNICTNGICSRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W6QHT5</accession>
    <name>W6QHT5_PENRF</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S04g000447</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OMA" id="RHYNDGR"/>
    <dbReference type="OrthoDB" id="4357160at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="44"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM35566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="184" mass="20172" checksum="CEB9A306547650A6" modified="2014-04-16" version="1">MDNEAKKTTEAASDLNPNGFITDRELDGERRSIRHYNDGRVSGRGRSVEGSLRTTMRKNSTRTGNRSRPLTSHSRDSGGRSTPIVFNPSDIADITAAMAKLTVDHPTSPKVKRLSKKLNFDAGPGIEIVTLRRVTPSPTASVASSICSTGSNSSVNARIAEIEDRLKKHIKTRLQSIKEEDEEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>W6QI47</accession>
    <name>W6QI47_PENRF</name>
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        <submittedName>
            <fullName evidence="6">Ras guanine nucleotide exchange factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PROQFM164_S03g000583</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM164</strain>
        </source>
    </reference>
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    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="REM"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Son of sevenless (SoS) protein Chain: S domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000651">
        <property type="entry name" value="Ras-like_Gua-exchang_fac_N"/>
    </dbReference>
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        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF363">
        <property type="entry name" value="PROTEIN SON OF SEVENLESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00229">
        <property type="entry name" value="RasGEFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RASGEF_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="370"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GEF" evidence="4">
        <location>
            <begin position="1412"/>
            <end position="1655"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="52"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="123"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="590"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="842"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="945"/>
            <end position="973"/>
        </location>
    </feature>
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        <location>
            <begin position="1004"/>
            <end position="1084"/>
        </location>
    </feature>
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        <location>
            <begin position="1120"/>
            <end position="1142"/>
        </location>
    </feature>
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        <location>
            <begin position="1169"/>
            <end position="1197"/>
        </location>
    </feature>
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        <location>
            <begin position="1306"/>
            <end position="1338"/>
        </location>
    </feature>
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        <location>
            <begin position="59"/>
            <end position="70"/>
        </location>
    </feature>
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        <location>
            <begin position="133"/>
            <end position="151"/>
        </location>
    </feature>
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        <location>
            <begin position="633"/>
            <end position="642"/>
        </location>
    </feature>
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        <location>
            <begin position="842"/>
            <end position="858"/>
        </location>
    </feature>
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        <location>
            <begin position="1004"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1306"/>
            <end position="1316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDM33859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="1658" mass="183819" checksum="29419ABEA7776911" modified="2014-04-16" version="1">MEPFPPPVDPSEFKDAFLGPQVQINELPASNQMSSGGPQNPIPNLRRANTVAQTGNVKRNLELKAARERTATGISAKDSHEPIRQNKLQRSQTHRGPLEARSPGRKAGHFTVRSVGQNGKIFLRPIANPPQTSPQLASFSPVDTSKSSPLQPQCHAHTREDANPFRWSSSQLSELRPRQQPEDPDPVLAVSPPELSNLHRTRPVSFSTISDQQSIAGAGKRGELRIVIDRSEDRPKSAGENSTPALEVPIPRYRLGSPRFNTEGSAIMQSSVYTRTSMSDNFPDSTLLGGRADPLLGLHSPYPRDSFSRHRPSFAISMFSGTAAAMDMNRAEPVPRNSMVYELEEPVEPSIYETLVYDMDDGSVVRYIPGTKDISAATPARIVAQISSESFMDYELVSDFFLTFRSYLSTTHLLALLLARLKWAINRLQDDGRIIRIRTFAALRHWILNYFVDDFVTNYELRTHFCETINKLYSEVRSRQHGGTSDRKILIDLKRCWNGKCSVYWSSPDLSRAYNDPEISIVPGDAQIELPKVEELQKNVPIHGTTPRANTTFRESLAFPIQHDRNDSAATSQSIPFSDKSEQSLMALSCSLPPKSPRRFSMSASKGKAPRPVVLGLTKSKSPSRTHEPPRSPVSSMVSRHPYTSHSHKRSGSFSDSVRDGRLPIFAMEPETGPAPQEMLDPVSLIRGEMYPPAESYMTMMAPESPPLPPPLKNLNPDRRSTPGVPKSSPNSGMRTIIGSIKRALHTRNGGQSVSARIANAHEAISSPSRGKTSAMPIGLAFGSEFYRERKMAATPKYPGRIDLLCDEVLKQYRLAMNQEGTKEKTQPPAASDFHQVTPQEPAANTSNLVPTQTPNSDSKLRSGITMGSESIIIVDDTGFEMPFMSGAAQEPMPIVNDNTCETPELEMPDNASTQSIPVEGEHLRPVCYNAEKSVSAAQSNMFYPLRPLTPQRSSSAERGSMPTRKKNNSLSLRLRKYASFQSGISKQRFSMGSETAQSTIDSLAMQDQNNKQSGPVLRRRRGGNLRQMQSGDEAEPPSCRDSFASWDDSAVDEMGSSDGGVSSPPSTLIPPKPQYSLIQPRSSRQIRRSFESVIAKFAQIPDDGDGGIESTLLKLEGKWDGPSSANRDDSSAPAEGPHSHREHFLIPHCVETSKPGWDVLSRRRQTDHSAYSTVGGRLAPPRPYSDSVTESEESFNSIPLLERGLTDESMKWQPTSQPLQYDSHGAPLTLVSSYETSELASSHPSIQIVHETDSMRRIPRGATIPASATHDAGQVTPKRLSALSSEMSVDLIDPREAIGARISTDTRSLSSSTVEIPSHPLAQPPSPPMTIQHPGSFTSYPSPLNTVLFQAQPLTPDTSPRRKEVGISSSRPLDIQQVSSDVLFNSENNRSDQNPIINTLPDHVPFILACESQVLAHQLTLIEMAALSEVDWRDLVEMRWSSACPLVTNWVQFLTYEERKGIDLVVGRFNLMVKWILSEIVLTRDINERARTIIKFIHTAAHARRICNYATMLQIAIALSSSDCSRLQSTWQLISIEDKRLFKDMECLIQPVRNFNDLRVEMETANLQEGCIPFIGLYVHDLTYNAQKPAQVNNTNGGLLVNFERYRTAARIVKSLLRLIDASTKYRFQPVQGIIERCLWIACLPEDEIQSRSKALE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W6QIH2</accession>
    <name>W6QIH2_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S04</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S04g000672</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QIH2"/>
    <dbReference type="OrthoDB" id="4357212at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM35791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="203" mass="22730" checksum="F291F692CE9B4E0F" modified="2014-04-16" version="1">MANNPVRSEDNLIRSDVPTHIDDRGAGSLDILKQSQSETSGPGNKNKLLVTTHHESSFPSWTPSPKKEWRVREGPVASNTSPRAAPTIRYSSRELIEGPAFIKSLIEGSTSWKEQEELYQAEFGVFRSQFRLVKRFGLVDMKNGGFGKGAFKKSSRQLKSQSTYTNVERRESSPIEASQAIRRAREKKRDKGKKRDPGPSDPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>W6QJ88</accession>
    <name>W6QJ88_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Actin-like protein arp5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">arp5</name>
        <name evidence="7" type="ORF">PROQFM164_S03g000973</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the actin family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QJ88"/>
    <dbReference type="STRING" id="1365484.W6QJ88"/>
    <dbReference type="OMA" id="YPFTEHV"/>
    <dbReference type="OrthoDB" id="7340501at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd10211">
        <property type="entry name" value="ASKHA_NBD_Arp5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000048">
        <property type="entry name" value="ARP5 actin-related protein 5 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000139">
        <property type="entry name" value="Chromatin remodeling complex subunit (Arp5)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000025">
        <property type="entry name" value="Chromatin remodeling complex subunit (Arp5)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000058">
        <property type="entry name" value="Putative actin-related protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="519"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="442"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM34249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="754" mass="86539" checksum="FF3E23604DF794D3" modified="2014-04-16" version="1">MTITSVHTLLPARIASNASEKRTEKPPPKLYTVQDFPFKGYHPPQPEGYQQSKAHPDTSAIVIDNGSHLVKAGWSFDKNPRFAIPPVMSRYRDRKLNRQCQFIGYDAYVDATTRGQLRNGFDPGSSVVGNWDVMEGVLDYLFLKLGVDGADGGVGRPILMTEPIANMPYSRKMMNEILFECYSAPSVAYGIDSLFSYRYNGGTDGLIVDSSHTSTHVIPVMNSKPMLSNCTRLNWGGLQSAEYLMKLMKLKYPTFPTRLTDAQMEEMVHQHCYVSQDYERELSGFLDWTGLEDRDRVIQYPFTEHIIQEKTEEELARIAERKKESGRRLQEQAARMRLEKLVKKEQELEYWKDLQETLANETKKEIRRILEAEDLKDEAALEKLIRELEKSIKRSRNKDLGIEETEEQPEEMTFPMLDIPDDQLDEAGLKEKRHQRLMKSNVDARLRAKEEKEREKARIEAEERLDREARENDFENWIAKRRNNRQGILQRIKDRDRFTADLGNRKSLASQMRMKTLANLASDGPKKRRRGGDDDDFGANDEDWGVYRTVAVGEGSDDEEEEDLNGMLNSVEKELLEYDPEFTENNTFAAQSDWTKSLVHAFLRGPWPFDPESQREAHQLHLNVERIRVPEVVFKPSIAGLDQAGLIEIAADIINQRYSNPADQSLLLKDVFLTGGNTLFTGFDERFRKEVRGFLPIEATLNVRKASDPVFDAWKGAAQWASGGDLGRSSVTRQEYLEKGSEYIKEHELGNATW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W6QJA4</accession>
    <name>W6QJA4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="20">Dicer-like protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">dcl2</name>
        <name evidence="20" type="ORF">PROQFM164_S03g000993</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Dicer-like endonuclease involved in cleaving double-stranded RNA in the RNA interference (RNAi) pathway. Produces 21 to 25 bp dsRNAs (siRNAs) which target the selective destruction of homologous RNAs leading to sequence-specific suppression of gene expression, called post-transcriptional gene silencing (PTGS). Part of a broad host defense response against viral infection and transposons.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the helicase family. Dicer subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1365484.W6QJA4"/>
    <dbReference type="OMA" id="HFCAVIP"/>
    <dbReference type="OrthoDB" id="416741at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050688">
        <property type="term" value="P:regulation of defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030422">
        <property type="term" value="P:siRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18034">
        <property type="entry name" value="DEXHc_dicer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00593">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd18802">
        <property type="entry name" value="SF2_C_dicer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1520.10:FF:000015">
        <property type="entry name" value="Dicer-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001669">
        <property type="entry name" value="Dicer-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1520.10:FF:000032">
        <property type="entry name" value="Dicer-like protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002480">
        <property type="entry name" value="Dicer-like protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.380">
        <property type="entry name" value="Dicer dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038248">
        <property type="entry name" value="Dicer_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005034">
        <property type="entry name" value="Dicer_dimerisation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14950">
        <property type="entry name" value="DICER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14950:SF37">
        <property type="entry name" value="ENDORIBONUCLEASE DICER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03368">
        <property type="entry name" value="Dicer_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00636">
        <property type="entry name" value="Ribonuclease_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00535">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51327">
        <property type="entry name" value="DICER_DSRBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00517">
        <property type="entry name" value="RNASE_3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50142">
        <property type="entry name" value="RNASE_3_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="3" id="KW-0930">Antiviral protein</keyword>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0347">Helicase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13" id="KW-0464">Manganese</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="11 15" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="17">
        <location>
            <begin position="22"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="18">
        <location>
            <begin position="362"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="domain" description="Dicer dsRNA-binding fold" evidence="19">
        <location>
            <begin position="558"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="domain" description="RNase III" evidence="16">
        <location>
            <begin position="919"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="domain" description="RNase III" evidence="16">
        <location>
            <begin position="1088"/>
            <end position="1271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00025403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CDM34269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="1375" mass="154715" checksum="44E7822619AAF92E" modified="2014-04-16" version="1">MDSTGLGSDGAAYRSRGYQLEMLEASRKENIIVAMDTGSGKTHIAILRIIDELENASSPDKLIWFLAPTVALSLQQHQVITSHILSVKTKVLTGLDNVDRWTDQGIWDKVLKDVRVVVSTYAVLADALGHGFVRMPRLALLIFDEAHHCTRRHPANKIMQNHYHPTLLRSGPNAVPRILGLTASPVVRSTQNELETIESNLNAVCKTPRVHRTELLENTHRPHLERLNYIHFDEAQYGLGSRLLPSLIECCRAYNIDDDPWIESLRLKDQIVELAKALNTGKTFCSEQLRMFEARSRHIYEELGGWAADFFISASIDQLQLSIQDASEMSHLDQRERIYLLELLLTMPTPVAAEENNHVSIKLEMLLNYLEKMDRPGFSGLLFVKQRATVSVLARILSLHPKTRDRFQCAAYVGWASDKNRKGCLGDLLHRDMQRNTLDEFKAGRKNLIVATDVLEEGIDVSACSLVICYDKPANLKSFVQRRGRARHRESTYAVMISNEDELLSLQKWQELEQAMIKAYQDDERQRREAYAIEDTEEHVNETLWVEKTSALLTADDALQHLHHFCAVLPVDEYSDNRPMFSFQENSVGLLLGTVTLPNSVHPTVRRTTGKAWWRTERAARKETAFQAYKALYSYGLLNDNLLPLTRKPELRFSEQMTLPSIVQAAEQYDPYVELAQGWASGQLCQTRLNICSNGSPDKDLAVCLILPRLTPMPHPIPLYWNPETSLELYFDPQVSTFEATVETLEYMRKTTALYLQAPSSRQRGEERDFVALFIPDIPHEYLGQWLAVHEGKEPALEVYSRNPTTPPTGIVRDQSKFSEPRIFNRWVVPAEVTKTSPIEVECSSLPRRRNLLQVRTINITGDGEVDAPKKSHVLPAAACVIDKLPAKQAVFGLFISAILDRLEASLVAHRLNDTILKGVGIQNIDHVITAISAPIAQASTNYQRYEFFGDSVLKFTVSCQLFFRNPKWHEGYLSESRDKLIQNSRLARAALDTGIDCFVLTSRFTPRKWAAPLIRNKLDPSTAKRKMSSKVLADVVESLIGAAYVDGGIRKAQACLHRFLPEIDLFTNEISSLLPPPGKGVSNLINHHRLAGLIGYTFSDPAILTEALTHASCEYDTSTQSYQRLEFLGDAVLDMVVMAVIAAHPVEMDQGPMTLLKHSVVNANLLAFFCMELSAPDEPSHITQFANGEVNLVPHYNQIHLWRFLRSHGPNITSAREACLERHQGLRAEILDALRNERQYPWELFARLRADKFLSDIVESVLGAIFIDCGGNLDVCYAFVERIGLVWYIQRVIADGVDVVHPRNTAQNMVKGAGTLVFKRKRVESGGVGTYRCTAVVNDTEIALVEGCASAEEAEVKVANIAIEYLTLHPLAST</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>W6QJB0</accession>
    <name>W6QJB0_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="10">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PROQFM164_S05g000721</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QJB0"/>
    <dbReference type="OMA" id="FIPASYF"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000134">
        <property type="entry name" value="MFS sugar transporter protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF64">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="23"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="64"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="94"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="118"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="153"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="192"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="341"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="375"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="440"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="26"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDM36888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="504" mass="55630" checksum="183A5533D24F2AE1" modified="2014-04-16" version="1">MASKVLHNNTNSSWMKDPGLRKLNLGIGFMLSASATAGYCASMINGLLVLPEFSNFLKDLDTNARGLIIAAVSLGSFCSFIPGSYIADNLGRRICVLIGSTLVIIASIIQVATNNPWVFFFARVLAGIGVGVSQTAAPLLITESTHPRQRQTFTGLYNALWFIGSITSAGIGFAGLTIVGSWSWKLPCLTQIFYPVLQLVGLCFVPESPRWLVSRGRKDEGMAILARYHANGDENDELVQDEFYQICKSINAESDKSCRRWSSFFASRSNMHRLSICVILGFMQEWSGNGVVSYYLAPILASVGIYNASHQAAINISLQVWNLAFAVGGAMAADRYGRRKLWLIATMLMFIYLSAATTMSGLFQEMHVLEAGIAVVPMLFLFCSAYDMAYMPLFIAYPAEILPFQLRAKGLAITLTTDSMACFFNQYINPVALAAIHWKYFLVYLGCLVIFMATIYFLFPETKGLSLEEVARIFEKDKAYQVERTPSDVSQELLVFPQKGSTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W6QJZ1</accession>
    <name>W6QJZ1_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S02g000036</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM29887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QJZ1"/>
    <dbReference type="OrthoDB" id="4232174at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM29887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="130" mass="14617" checksum="8C2B5ECE02E271BB" modified="2014-04-16" version="1">MTAQFTHANATNQSTTKRNALLGSIKYKMLALKDFEECHVLAGWIRQLFFDMFEQQRGQDKNGHSPEAAGEDFNIPNSEALDTVGDTSMALDVDSIIADIPRPAPWELPYTMSNDNILWHNWLLGYQDGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W6QKE8</accession>
    <name>W6QKE8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="5">60S ribosomal protein L9-B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">RPL9B</name>
        <name evidence="5" type="ORF">PROQFM164_S02g000211</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL6 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QKE8"/>
    <dbReference type="STRING" id="1365484.W6QKE8"/>
    <dbReference type="OMA" id="YAHFPMK"/>
    <dbReference type="OrthoDB" id="10252633at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.930.12:FF:000003">
        <property type="entry name" value="60S ribosomal protein L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.930.12:FF:000004">
        <property type="entry name" value="60S ribosomal protein L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.930.12">
        <property type="entry name" value="Ribosomal protein L6, alpha-beta domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000702">
        <property type="entry name" value="Ribosomal_uL6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036789">
        <property type="entry name" value="Ribosomal_uL6-like_a/b-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020040">
        <property type="entry name" value="Ribosomal_uL6_a/b-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002359">
        <property type="entry name" value="Ribosomal_uL6_CS2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655:SF16">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655">
        <property type="entry name" value="60S/50S RIBOSOMAL PROTEIN L6/L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00347">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002162">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56053">
        <property type="entry name" value="Ribosomal protein L6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00700">
        <property type="entry name" value="RIBOSOMAL_L6_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL6 alpha-beta" evidence="4">
        <location>
            <begin position="14"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL6 alpha-beta" evidence="4">
        <location>
            <begin position="97"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDM30062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="192" mass="21728" checksum="B254FF984B069CBF" modified="2014-04-16" version="1">MRYIHSEERLPILDNVKVQIKSRVVTVEGPRGKLVKDLSHIAVTFGRPEQNVISIELHHGARKGVATLRTVRTIINNLMIGVTRGFKYKMRYVYAHFPINVNIEPNPETGRAIVEIRNFLGEKYVRRITAQPDVDIAPSANVKDELILTGNSLEGVSQSAADIQQICRVRNKDIRKFLDGLYVSEKGNIIEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>W6QKI1</accession>
    <name>W6QKI1_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RBR-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PROQFM164_S05g000763</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.31"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.3.2.31" evidence="2"/>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QKI1"/>
    <dbReference type="STRING" id="1365484.W6QKI1"/>
    <dbReference type="OMA" id="HRFCMIC"/>
    <dbReference type="OrthoDB" id="10009520at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20346">
        <property type="entry name" value="BRcat_RBR_ANKIB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20356">
        <property type="entry name" value="Rcat_RBR_HHARI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16625">
        <property type="entry name" value="RING-HC_RBR_HEL2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1750:FF:000007">
        <property type="entry name" value="RBR-type E3 ubiquitin transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000019">
        <property type="entry name" value="RBR-type E3 ubiquitin transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045840">
        <property type="entry name" value="Ariadne"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048962">
        <property type="entry name" value="ARIH1-like_UBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031127">
        <property type="entry name" value="E3_UB_ligase_RBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11685">
        <property type="entry name" value="RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19422">
        <property type="entry name" value="Ariadne"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01485">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22191">
        <property type="entry name" value="IBR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21235">
        <property type="entry name" value="UBA_ARI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00647">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="12">
        <location>
            <begin position="132"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="11">
        <location>
            <begin position="136"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="23"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDM36930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="510" mass="58583" checksum="90E7F0B4C210D469" modified="2014-04-16" version="1">MDSDDDFMSDVSSQDDFLGTQGSDDESLGEDFDDLDAGFSDDKDLIKHKKKPYEVEFKVLAPADIDHEQLGQVNEVCAILGLPPESAAILLRFGRWNKEKLIESYMEHPEQTLEEAGLGSNFEGTAKTECIPGFMCDICCEDGDDLETYAMRCGHRYCVGCYRHYLAQKIKEEGEASRIQCPGDRCNRIVDSKSLDLLVTKELQGRYRELLTRTYVDDNENLKWCPAPNCQYAIDCGVKQRDLRRIVPTVRCFCKNEFCFGCSLSDHQPAPCTLVKMWLQKCEDDSETANWISANTKECTKCNSTIEKNGGCNHMTCRKCKYEFCWMCMGLWSEHGTSWYNCNRYEEKSGADARSAQAKSRSSLERYLHYYNRYANHEQSAKLDKDLYLKTEKKMTSLQSQSGLSWIEVQFLDTASQALQQCRQTLKWTYAFAFYLARNNLTEIFEDNQKDLEMAVESLSEMFEKPVAELAGLKVDILDKTTYCNNRRVILLSVTAENLKNGEWTFNIDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W6QKI5</accession>
    <name>W6QKI5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S03</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S03g001454</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QKI5"/>
    <dbReference type="STRING" id="1365484.W6QKI5"/>
    <dbReference type="OrthoDB" id="73875at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM34729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="116" mass="13604" checksum="788EACA07886BC44" modified="2014-04-16" version="1">MIATRKLPSRLKIEAEATVGRFCRAELILGECGNKTLTFKQETCSKDFFMDRVVGYYEGWATHRRCHESWPEQIRDIDLYSRLTSAKASDKDLKVMMARQPQIQRPWPSRNSFFLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W6QL58</accession>
    <name>W6QL58_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Amino acid/polyamine transporter I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PROQFM164_S06g000151</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792020">
        <property type="protein sequence ID" value="CDM37190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OMA" id="IEFRYWK"/>
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    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000001">
        <property type="entry name" value="Amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF1">
        <property type="entry name" value="GENERAL AMINO-ACID PERMEASE GAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="57"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="122"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="164"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="198"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="282"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="338"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="380"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="409"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="451"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="487"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="9">
        <location>
            <begin position="57"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="11"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CDM37190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="563" mass="62387" checksum="5EE5328D183DA734" modified="2014-04-16" version="1">MNQSSIQTSKDAFELKTNETNDIERSASSGTERHGNTLVLSASDDAGYHRSLTRRQIMMMTFGAGIGTGLWVGTGQALHYAGPAGIAITYTITAMIVYAQYSSIGEMTTYKPIHGGFIRQCAEYVDPAFGFAIGVNFWFAWVMIIPAEITAAISVLKYWPQTDVVPLAGFITIFLVVFAIANMFHVRVYGYIEYYMSFVKCIAVILMIFFMFIMTSGGIAATNGPIEFRYWKNPGAFNNGIKGISKAFVQAAFSFGGGEHIAVIAGEVADPRRTIKKTVRPVFWRMFTFFVVNIWLVGMCVPSNDVDLVNASGTMGSPFVIAVKRADVYGLAHAINGFIFLSVISCGITSVYIASRSLTALADLQIIHPFFGRKDSQGRPYVSLLISLGLGGGLGYLNCNSVGTLVYSWFSALVAIATLFQWGSIYIAHLRFRQGLRAQNKDLSALPFKGLLTPWAQYFSLLIVAFVFGCEFYLACWPFGEKGSVKSFFSSYLAAPLFVFDYFAYKWYFKTKIVKPVDMDFGPARAFDEQDLINAIAAEDAERNPENDKQKTWRKRAQYAVFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W6QLA1</accession>
    <name>W6QLA1_PENRF</name>
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        <submittedName>
            <fullName evidence="2">Glucose-repressible gene protein</fullName>
        </submittedName>
    </protein>
    <gene>
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        <name evidence="2" type="ORF">PROQFM164_S03g001711</name>
    </gene>
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        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
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        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR020100">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR38789:SF1">
        <property type="entry name" value="GLUCOSE-REPRESSIBLE GENE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38789">
        <property type="entry name" value="REPRESSIBLE PROTEIN GRG1, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G14210)-RELATED"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM34984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="73" mass="7893" checksum="CFB573E0BCBB3522" modified="2014-04-16" version="1">MDTVKNAANYVAETVQGTGAEASKETNKQVAKDDDAKLSTRAAAAKDALVDKKDEKSHDVKADVHKEQVKHQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W6QLF9</accession>
    <name>W6QLF9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S06g000221</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792020">
        <property type="protein sequence ID" value="CDM37260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="10404677at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM37260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="61" mass="6775" checksum="2D7FF69A4CBD0F75" modified="2014-04-16" version="1">MPWVIRSNMVQGTRGPYSWDLEQVINTLLREAQSCGNLHSRGNLYSCGRLNPAGGSILREA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W6QLG1</accession>
    <name>W6QLG1_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Aconitate hydratase, mitochondrial</fullName>
            <shortName evidence="9">Aconitase</shortName>
            <ecNumber evidence="9">4.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PROQFM164_S03g001781</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM164</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="9">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the aconitase/IPM isomerase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.-" evidence="9"/>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM35054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QLG1"/>
    <dbReference type="STRING" id="1365484.W6QLG1"/>
    <dbReference type="OMA" id="KWPETFG"/>
    <dbReference type="OrthoDB" id="2224430at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003994">
        <property type="term" value="F:aconitate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.19.10:FF:000002">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000003">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000004">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1060.10:FF:000001">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1060.10">
        <property type="entry name" value="Aconitase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="entry name" value="Aconitase, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="entry name" value="Aconitase, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050926">
        <property type="entry name" value="Aconitase/IPM_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018136">
        <property type="entry name" value="Aconitase_4Fe-4S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015932">
        <property type="entry name" value="Aconitase_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006248">
        <property type="entry name" value="Aconitase_mito-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01340">
        <property type="entry name" value="aconitase_mito"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005558">
        <property type="entry name" value="PRK07229.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43160">
        <property type="entry name" value="ACONITATE HYDRATASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43160:SF2">
        <property type="entry name" value="HOMOCITRATE DEHYDRATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="Aconitase iron-sulfur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01244">
        <property type="entry name" value="ACONITASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0408">Iron</keyword>
    <keyword evidence="6 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha" evidence="10">
        <location>
            <begin position="67"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="domain" description="Aconitase A/isopropylmalate dehydratase small subunit swivel" evidence="11">
        <location>
            <begin position="597"/>
            <end position="724"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDM35054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="798" mass="85230" checksum="EE45C6D1BAA8DD12" modified="2014-04-16" version="1">MVSQLVWQRVSASRGMATRLSSQRLFARGLATEASSSRMPPYPKLVRNLEHVRRVLGSDRALTLAEKILYAHLDNAEESLLTGTNNGRDIRGKANLKLKPDRVAMQDASAQMALLQFMSCGLPSTAVPASIHCDHMIVGERGADTDLPASIKGNSEVFDFLESAAKRYGIEFWPPGAGIIHQSVLENYAAPGLMMLGTDSHTPNGGGLGAIAIGVGGADAVDALVDAPWELKAPKVLGVRLEGKLSGWASPKDIILSLAGKLTVRGGTGYIIEYHGPGVETLSCTGMATCCNMGAEVGATTSIFPFSPSMVPYLQSTHRGYVADAATEVASAGPSSLLRADTKAEYDQVVTINLSELEPHINGPFTPDFSVPLSKFADTVREKKWPETFGAGLIGSCTNSSYEDMTRAEDLVKQATAAGLKPKADFFITPGSEQIRATLDRDQTLNTFSEAGGIVLANACGPCIGQWKRTDGVPNGEDNAIFTSYNRNFPGRNDGNRRTMNFLASPELVTALAYSGSTTFNPMTDSLTAPDGSAFKFQPPSGFDLPSAGFEEGNPNFLPTAAVPDASSEVIVSPTSDRLALLEPFAPFPKGDLSGLQVLYKVKGQCTTDTISAAGPWLKYKGHLPNISANTLIGAVNAATGETNVAYDEAGKQYGIPELAEAWKERGISWLVVAEDNYGEGSAREHAALQPRYLGGRVIVAKSFARIHETNLKKQGVVPLTFTNREDYDRIDACDKVDTVGLYDVLQTGGQGEIKLRVTKQKTGEVFEVPVQHTFSQDQCGFILAGSALNLLAKKAHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>W6QMY3</accession>
    <name>W6QMY3_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S02g001147</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QMY3"/>
    <dbReference type="OrthoDB" id="4366283at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM30997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="79" mass="8900" checksum="5D8C786C170B2156" modified="2014-04-16" version="1">MSLFGLTPQSPTWRTPSCSWMADGIRDDLEVSLRLDWILQDRHVSFLQGYYHLVLDVAIDSPVDAFYSDAGGFHPSGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W6QMY5</accession>
    <name>W6QMY5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ribosomal protein L7/L12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PROQFM164_S04g000405</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL12 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QMY5"/>
    <dbReference type="STRING" id="1365484.W6QMY5"/>
    <dbReference type="OMA" id="LEDKWGV"/>
    <dbReference type="OrthoDB" id="250175at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00387">
        <property type="entry name" value="Ribosomal_L7_L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1390.10:FF:000001">
        <property type="entry name" value="50S ribosomal protein L7/L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.710">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00368">
        <property type="entry name" value="Ribosomal_bL12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000206">
        <property type="entry name" value="Ribosomal_bL12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013823">
        <property type="entry name" value="Ribosomal_bL12_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014719">
        <property type="entry name" value="Ribosomal_bL12_C/ClpS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008932">
        <property type="entry name" value="Ribosomal_bL12_oligo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036235">
        <property type="entry name" value="Ribosomal_bL12_oligo_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45987">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45987:SF4">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL12M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00542">
        <property type="entry name" value="Ribosomal_L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16320">
        <property type="entry name" value="Ribosomal_L12_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54736">
        <property type="entry name" value="ClpS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48300">
        <property type="entry name" value="Ribosomal protein L7/12, oligomerisation (N-terminal) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein bL12 oligomerization" evidence="5">
        <location>
            <begin position="58"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein bL12 C-terminal" evidence="4">
        <location>
            <begin position="125"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDM35524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="192" mass="20132" checksum="C3B1BDAF91120098" modified="2014-04-16" version="1">MSFSTQVAARCARQLSGSVRPSSLRIGASATYLTARRTPSSRRCESTQAAPAAATNPKISQIVDQISTLTLLETADLVSSLKTRLNIPDLPVGGFAMAAGGAPGAAAAAVEEEEAAPAAAEKTLFNLKLESFEPTSKPKVIKEIKTMLGLSLVDSKKFVESAPKILKESVPKEEAEKLIATFKAIGAKATME</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W6QNF7</accession>
    <name>W6QNF7_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S02g001332</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QNF7"/>
    <dbReference type="OrthoDB" id="4369748at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM31182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="110" mass="12282" checksum="2DC652AF4AECFF4A" modified="2014-04-16" version="1">MSVKPVSCQYIWTSPLRQDSNSVGCTEYVCCMKNLLNKPVPTGLDFNRLNGVRVIIDRVNRETGFWLEIQVSIVRAIADLLSLNNGPQHPSVETKPRVALHPTRALCCTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W6QQ83</accession>
    <name>W6QQ83_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RING zinc finger-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S05g000057</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
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    <dbReference type="OrthoDB" id="5405791at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="Znf_RING-like"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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            <begin position="426"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="273"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM36224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="508" mass="55896" checksum="BDA3B5910E3B22CE" modified="2014-04-16" version="1">MPPRSSLTSSFSVTDANNEVVCPLKNNDSSNCRKRCLGEKRYRSMQEHIRRAHPNHYIPKLPATEESFLMMVNTPLEQRVQLSPPEPAQPRRPHDVAPERDIYVADGSPPTPRALDEPHPAAATAAVALAQLHHHRLASDWDTDMDTHSDTDLSHPRMRGAIELPPLRDHFKQESLPPFTPRPRELLPSILNHSPPGRSSTLPPIQRRDKFCRPRKSSITQSARKPKQDRPKSKEFGRRPSLGDRKALSAEPQTAAWAQGKRWEDLIEAATSATEVDDEPYSEAGRSPTIAPLLSSVTSAPSGVKNRSSLPPAFQSTGLPPISSHRPFPPHSYAASPLHKSLTPPPYENHRSRESDLEPFPSIESSLDSMSSASGRNFASSVSGVAPSINSDSSPVMNLIPSLSQRQHHRFSNPTPASFRNKEVQVFCAQCKRPSALNECYACTECICGVCRDCVGMFISSPPASFRTPGNGPLNNASQGPTSYPGPRGCPRCRTVGGKWKAFQIDIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
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        </recommendedName>
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            <taxon>Pezizomycotina</taxon>
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    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
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            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
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    <dbReference type="Proteomes" id="UP000030686">
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR42057:SF2">
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM36544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="454" mass="52974" checksum="445FEFA010ECC50B" modified="2014-04-16" version="1">MSRLLNFPSERLARTFFNVDLSSLKSLRQSCRFTSQLATDQPFRTVHLQPSETSQNGLQEILNNPSLHWTPRKIYIDTVDESLDYDDGEEQKWPQGWDNLVPQVKELPRLNAAVLCFDKGFTSDSRDRDYLHYTDFPQTPQFRFHAMHKLFSLLESLRHPIQDLGIRNLQADNPKDPKTLAKMEKVLSGLLSLRLSITSETNDAAPEHDLEYPEIRKFFKELPRTWLSPAAPSLQHLSLCSREYSGFYPHLDLSNLFFPRLKTLSLGNFCFFHDGQIDWILKHGDTLEEIYFDDCAVLYDFCMMKENVDACALPTDALLRREGSESLYGSFEKRWHHIFDLFAEKLPKLRHFRIGSSNWYPDIPFEQERDIKVGLYYNRYMCCYDGYGPSPYMEGEDPKELADLENAWRPSPECDDEDRAALRKLLAKLGQPVQESYSNRHCGGRIVDLVQRRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W6QRU8</accession>
    <name>W6QRU8_PENRF</name>
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        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S02</fullName>
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    <organism evidence="1 2">
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        <lineage>
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            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QRU8"/>
    <dbReference type="STRING" id="1365484.W6QRU8"/>
    <dbReference type="OrthoDB" id="540004at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM32247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="67" mass="7532" checksum="7EB4E66C9A2C372D" modified="2014-04-16" version="1">MGYTRFVLGGTRHFGYYEHGTWWPFPLSRALLAMEDKLAASLDLAPGGSILTYIRHRCDGCQARVAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W6QRW8</accession>
    <name>W6QRW8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Amino acid/polyamine transporter I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PROQFM164_S05g000652</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1365484.W6QRW8"/>
    <dbReference type="OMA" id="ELWYICI"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000001">
        <property type="entry name" value="Amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF26">
        <property type="entry name" value="GENERAL AMINO ACID PERMEASE AGP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="125"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="181"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="266"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="319"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="358"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="393"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="436"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="469"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="9">
        <location>
            <begin position="44"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="10"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDM36819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="509" mass="56109" checksum="14DDA71E6BE6D6B3" modified="2014-04-16" version="1">MADTSQNNPKDVKVSQDEPKDIQGTVEEGEISNGHLSRSLSQQHLMMMAIGGVIGPGYFVGMGTGLSTAGPAGLLICFSVVGILLWFVMQSLGELGAFISVSGSFTHYSSRFIDPAWGFALGWNYFFLWTGIIMAEYNNLGLILTYWDTSMPRWGWTLVFWVFFMSFALLGVWAFGEAEFWLALLKVLAIAIFFLCAILISSGVIGGQKIGFKYYEDPGPFTNGVKGVFEIFVFAALQYSGTEMIGLTAGESQNPNKDIPKAVKSIIWRIVVIFLGGIFFLTITVPSNDPNLLSESSKTASSPFVIAFNHVGAKKGADAVNAVILLTIFSAVNSAVYVGSRTLYGLAKEGAAPKMFLYTVRGGVPIVALVFFHLLGFLSFLNLSSSAGVVYTWVISMTGVATFITWGSICLCHIRIRKAMRLQNVSASILPYQAQFWPYGAYLGFGISVFFIFFQGWTSFAPWSVQKFFMNYVIVVVFIFLAISWKFWHKTSWVQLNTVDLMSGRRHIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W6QSL2</accession>
    <name>W6QSL2_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cytochrome b561, eukaryote</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PROQFM164_S06g000054</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792020">
        <property type="protein sequence ID" value="CDM37094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QSL2"/>
    <dbReference type="STRING" id="1365484.W6QSL2"/>
    <dbReference type="OMA" id="WVAVTHA"/>
    <dbReference type="OrthoDB" id="19261at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd08760">
        <property type="entry name" value="Cyt_b561_FRRS1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006593">
        <property type="entry name" value="Cyt_b561/ferric_Rdtase_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47797:SF1">
        <property type="entry name" value="CYTOCHROME B561 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47797">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G05805)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03188">
        <property type="entry name" value="Cytochrom_B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b561" evidence="8">
        <location>
            <begin position="17"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM37094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="150" mass="16717" checksum="943C2C34873F30BA" modified="2014-04-16" version="1">MFPFFALGLHLFPSKWTVDIHGTFQLLTLTVVIAGFGVGVSLARQIDLVNSYHTILGMIIVPSLILFQPAMGVLQHRFFRKTGRKGPFAYTHRWFGRLMMILGIINVGLGFKLAKAPRRAVIATSIVAGVIAMVYIVNVSWIGRPRRPNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W6QSZ0</accession>
    <name>W6QSZ0_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S02g002778</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QSZ0"/>
    <dbReference type="STRING" id="1365484.W6QSZ0"/>
    <dbReference type="OrthoDB" id="3897607at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF96">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM32627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="128" mass="14058" checksum="97AFC1BE8EE854F0" modified="2014-04-16" version="1">MYSAVVAACDFTIGSLPIFMVRRLQMKRGTKFAVPAILGLAYIASVAVIVRIPFLHYAGRPDFLWIAAGSLMTLRPLLRVLSKSGSSVTNQHRLVTSFPMLSSCSDGEDLESPCEYQTHSYNCGHFAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>W6QTR1</accession>
    <name>W6QTR1_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Proteasome subunit alpha type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PROQFM164_S06g000501</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="5">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the peptidase T1A family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792020">
        <property type="protein sequence ID" value="CDM37539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QTR1"/>
    <dbReference type="STRING" id="1365484.W6QTR1"/>
    <dbReference type="OMA" id="NTQVYGK"/>
    <dbReference type="OrthoDB" id="431557at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03749">
        <property type="entry name" value="proteasome_alpha_type_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000016">
        <property type="entry name" value="Proteasome subunit alpha type-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035144">
        <property type="entry name" value="Proteasome_alpha1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 4 5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="6">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM37539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="257" mass="28198" checksum="9A98BD77070115B2" modified="2014-04-16" version="1">MFRNNYDNDAVTFSPQGRIFQVEYAQEAVKQGSVVVGLVNKTHAVLVGLKRNAEELSSYQKKIIEIDSHMAIAIAGLASDARVLSNFMKQQSLGSKMTYGRPIPLDRIVAQIGDRAQTNTQHYGKRPYGVGLLVAGVDEAGPHLFEFQPSGLTHEMLACAIGARSQMARTYLERNLDKFEDCSRDELIQHGLSALKETLSQDKELTVDNTSVGVVGVTNGKKESFKLYEGQDTAVLLEVLEQRESAGAEGESMEVDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W6QU49</accession>
    <name>W6QU49_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Aldehyde dehydrogenase domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PROQFM164_S02g003208</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM33057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QU49"/>
    <dbReference type="STRING" id="1365484.W6QU49"/>
    <dbReference type="OMA" id="ELSPCSY"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004777">
        <property type="term" value="F:succinate-semialdehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009450">
        <property type="term" value="P:gamma-aminobutyric acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07105">
        <property type="entry name" value="ALDH_SaliADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000012">
        <property type="entry name" value="NAD-dependent succinate-semialdehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050740">
        <property type="entry name" value="Aldehyde_DH_Superfamily"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353:SF2">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_8G05520)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353">
        <property type="entry name" value="SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="4">
        <location>
            <begin position="22"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDM33057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="482" mass="50662" checksum="1971147023A59169" modified="2014-04-16" version="1">MPNSTNPGFTVPLLINGHEETTPNTFPVTSPYTNTTIWTASAATPQDAIRAVEAASAAFPSWSQTKPTVRRDILLKAADLLEARLNMNAEYMRQEMGADVGASAGFVVPLAVRMLREVASRITSICGSVPVVETEGQSAIVFKEAMGVILGIVPWNAPYVFGIRSAACALAAGNTTVLKSSELTPRCYWAIGRAFEDAGLPAGCLNIIHCAPQDAPEVVNAMIEHEAVRKINFTGSTAVGRKIARACGQNLKPCLMELGGKNSSIVCRDADLQTAVQGVLAGAFLNSGQICMATDRILVHTSILPAFTEALQKALAAGAAASALPPTLVNTASKTRVEALIASAVSAGAHFISGSADSVPTDSGVRMAPAVLGGVTEDMALWQEESFASVAACMPFDSEDEAIRLANGSGYGLSASVFTEDLRRGLAMARRIQSGAVHINSMTIHDEPALPHGGVKNSGWGRFNTDEGLNEFLVTKSVTWMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>W6QWJ8</accession>
    <name>W6QWJ8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Kinesin, motor domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PROQFM164_S03g000621</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QWJ8"/>
    <dbReference type="STRING" id="1365484.W6QWJ8"/>
    <dbReference type="OMA" id="NRHPQKA"/>
    <dbReference type="OrthoDB" id="123929at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005871">
        <property type="term" value="C:kinesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000091">
        <property type="entry name" value="Kinesin family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000120">
        <property type="entry name" value="Kinesin family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24115:SF1008">
        <property type="entry name" value="KINESIN-LIKE PROTEIN SUBITO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24115">
        <property type="entry name" value="KINESIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0493">Microtubule</keyword>
    <keyword evidence="4 5" id="KW-0505">Motor protein</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="7">
        <location>
            <begin position="10"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="187"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="270"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="641"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="645"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="111"/>
            <end position="118"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM33897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="717" mass="79886" checksum="93480DC0116EE26A" modified="2014-04-16" version="1">MPPKQPQTSLFQVYLRLRPPMTPNPNECDRFLNVEAPEASQEETEIVSPASTHVTLQPPNDTRKRAVERFGFTKVFEETASQLDVFHDTGMEPIIRGVLKENRDGLVATLGVTGSGKSHTILGSKTQRGMTQMALDVIFRSLESTNKTDHGSITPVMLASLAVADASEAQLFSAQTFLEAVYGEPNGRTSRAQTPMSPSRANTPLTEPTPALNFPRRHIRERPCALPRLPDMSHLTVDMDSNADYVVLVSMYEVYNDRIFDLLSPSIASGQGNMSRGNNQKDRRRPLLFKSTEGSPDRKLVAGLRKIACSSYEEALAILDVGLTERKVTGTGMNSVSSRSHGFFSLEVKKRTYSKRTGEQNWAGNALTVVDLAGSERARTAKTAGATLAEAGKINESLMYLGQCLQMQSNIQDGMKTALVPYRQCKLTELLFSNSFPSSHQMSRGQYPQKAIMIVTADPVGDFNATSQILRYSALAREVTVPRIPSICESILSAASGSHRSISGSTSPNFDSAEELERAAAEITRLTRDCHGLAVKLAEEEIARADVEMRLSAAEERCLMIEQDVREECWAEMDEKMEEERRRWQRAWDEQIGRNDEHIDKKVELVSRGFQIFEDSASNERVEELEQENDQLRRKLAAFEREMHNQSPTRKNRPKNATSARSNPLGRGSDVENALQRMDQLKLADTMFAPPSPGSSPIKKTRKMGTRKWDLAPEDQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>W6QWM5</accession>
    <name>W6QWM5_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Clustered mitochondria protein homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Protein TIF31 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">tif31</name>
        <name evidence="4" type="synonym">CLU1</name>
        <name evidence="4" type="synonym">TIF31</name>
        <name evidence="8" type="ORF">PROQFM164_S03g000656</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">mRNA-binding protein involved in proper cytoplasmic distribution of mitochondria.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">May associate with the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CLU family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QWM5"/>
    <dbReference type="STRING" id="1365484.W6QWM5"/>
    <dbReference type="OMA" id="HPVWDKD"/>
    <dbReference type="OrthoDB" id="1414216at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048312">
        <property type="term" value="P:intracellular distribution of mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd15466">
        <property type="entry name" value="CLU-central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000293">
        <property type="entry name" value="Clustered mitochondria protein homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000532">
        <property type="entry name" value="Clustered mitochondria protein homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03013">
        <property type="entry name" value="CLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033646">
        <property type="entry name" value="CLU-central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025697">
        <property type="entry name" value="CLU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028275">
        <property type="entry name" value="CLU_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027523">
        <property type="entry name" value="CLU_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023231">
        <property type="entry name" value="GSKIP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12601:SF6">
        <property type="entry name" value="CLUSTERED MITOCHONDRIA PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12601">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT EIF-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13236">
        <property type="entry name" value="CLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15044">
        <property type="entry name" value="CLU_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12807">
        <property type="entry name" value="eIF3_p135"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103107">
        <property type="entry name" value="Hypothetical protein c14orf129, hspc210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51823">
        <property type="entry name" value="CLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 5" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="Clu" evidence="7">
        <location>
            <begin position="323"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="5">
        <location>
            <begin position="966"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="865"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1159"/>
            <end position="1242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1171"/>
            <end position="1194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1227"/>
            <end position="1242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM33932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="1242" mass="138046" checksum="3BD6E03550A36F49" modified="2014-04-16" version="1">MAETNGELEHSKEAPQASQEITNGNAPEGTEEDNTGGLFQITVKLPHAPHKIQVMVSSQEQVQDVRQSIVELPGTFQYTCFHLEFNGNRINDFVELSEVPDLEADSEIVLVEDPYTEKEARMHIVRIRELIGASGDRVDNLHGISAGLSLHDAITADAIKAGESDKEHSLSKYDLTGPSPLQTILPIAEAPLPKTVKSISLSAWNPVPYNLRQKGHLLYLVVSTNEGEQFQITAHVSGFFVNKCSSVRFDPSPKPTHPKKGSAHSLLTLISQLSPSFDASFEALQEYNNEKDLLTTFPFQNAIPNSPWLIAPSSSSLNAHQPDITRSQENYLISGVDNAETLRDWNEEFQTTRELPRETVQDRVFRERLTSKLFADYNEAAARGAVLVARGEVAPLNPTEARDAQIFVYNNIFYSFGADGVGTFTSEGGDEAARVAVGKDVLGIKAVNQLDIDGLFTPGTVVVDYLGKRIVGQSIVPGIFKQREPGEHQIDYGGVEGKEVVATHADFIPVFEKLSKALRVKQHPVWDKENKRHELEGSVETKGLLGTDGRKYVLDLYRVAPLDVEWQEEDGSDVYPHRMSVLRLELVESYWRHKMSQYVKAQVESRKAAAAEAAKEGKPEEENAEQDRVDISDFHLALNPDVFSGQVPQTEEEKKQWAKDEQEVRDACDHLRSKVIPDLLKDLHDGDVGFPMDGQSLTQLLHKRGINLRYLGTLAKQSAEKGPRLQALSILVVQEMVTRAFKHVANRYLNNVPAPFVAPCLAHLLNCLLGSDVNATPKAEIDESLRAIFPEGDFSFENVTPESLRAEIEKQVTIRFRFSLEKDWSNSLRYLQLLRDISIKLGIQLGARDFAFTKDQVKEQVVVPITNGSTHEEPKKKGKKKGGDNKSPTRAAPAPAKPAVTFTADDILNVVPLVRDASPRSALAEEALEAGRISLMQNQKQLGQELILESLSLHEQIYGILHPEVAKLYHQLSMLYYQTDEKEAAVELARKAVIVTERTMGVDSADTILSYLNLSLFEHASGNTKTALVYIKHAMDVWKIIYGPNHPDSITTMNNAAVMLQHLKQYNDSRKWFEASLSVCEDLFGKDSINTATILFQLAQALALDQDSKAAVSKMREAYNIFLTQLGPEDRNTKEAENWLEQLTQNAVSIAKHAKDIQARRLRRNPLNPRVSSMGTRVQPQVGQSAPEISTPTDPSALDSRSIDELLKFIEGSDATSSRSKQKKRAATSNPKLRGSKQSNKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W6QX81</accession>
    <name>W6QX81_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S03</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S03g000881</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QX81"/>
    <dbReference type="OMA" id="WNNDGCS"/>
    <dbReference type="OrthoDB" id="4353051at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM34157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="136" mass="14960" checksum="998F6087630BA0E0" modified="2014-04-16" version="1">MHFSKTLATAATFAMTVYAGFPVASVSFLSWEKCDIGRPALGEAKFSADVSVTPVTCDKTPVNRDWSIDNYSFRARLDTKDTVFCHGVTIWNNDGCSGEPVYFLPFEHSPFAEGQCLPDILQPGYVSFKLACEGFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W6QXB1</accession>
    <name>W6QXB1_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Anoctamin/TMEM 16</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PROQFM164_S03g000921</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QXB1"/>
    <dbReference type="STRING" id="1365484.W6QXB1"/>
    <dbReference type="OMA" id="YENHRTA"/>
    <dbReference type="OrthoDB" id="296386at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007632">
        <property type="entry name" value="Anoctamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049456">
        <property type="entry name" value="Anoctamin_N_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049452">
        <property type="entry name" value="Anoctamin_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12308">
        <property type="entry name" value="ANOCTAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12308:SF77">
        <property type="entry name" value="MEMBRANE STRESS RESPONSE PROTEIN (IST2), PUTATIVE (AFU_ORTHOLOGUE AFUA_4G03330)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04547">
        <property type="entry name" value="Anoctamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20877">
        <property type="entry name" value="Anoctamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="183"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="214"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="285"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="326"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="371"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="Anoctamin alpha-beta plait" evidence="8">
        <location>
            <begin position="18"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="Anoctamin transmembrane" evidence="7">
        <location>
            <begin position="173"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="686"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="686"/>
            <end position="697"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM34197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="749" mass="84550" checksum="11F5ED1B26286BAB" modified="2014-04-16" version="1">MSWLAAYSNDEDDNDNLGVDWVLQYEFGDVDQAQAITEFRTLIHDLGEAGLRVQVRHGHGEALLVCIRVPRDHLGNLVHQSRIKDWLFGITHTLPDGDETAIADADTPAEEIRSVYHAVTWQKKIGGAGITPGFGKWKNITASFPLHDQEACAQMLRQWNRKTVLTTSDLDAIRALFGEKVAFYYAFIHCYSLFLVVPAGLGILGWLYLGPYSIVYGTVLCAWCVVFVEYWKIREADLSQRWDVKGVGRLKVNRKQYVWEKEVKDPISGQVKYVFPGWKQFLRQLLLVPFASVASVALGALIVASFASEVFISEVYDGPFKEYLEFVPTVLFSLSLPAITSFLTSIATRLTKYENYRTQDQYDLALTQKNFVMNFITSFLPTILTAYVYVPFGKQIVPYFDILRRTGLTADMASGHKKFEVDTSRFQQEVIYLSMTAQVLSFGEEVVLPYVKHVLNQKWQNYRDGKAEYSRKRKHSATTSSFLVDSPDEAAFMKRLRSEAGAEEYHVEEDIMEMCVQFGYLALFGVAWPLVPLGFLLNNWLELRGDFFKLTLECQRPPPIRSDSIGPCLLGLDFLAWLGTLSTAAIVHVYRGPISEVRLSSLLLTLFVAEQVYLGMRFTASTALEKIFSDSIRREEAIRYAVRKDYLAASLARNSSLSSGSQGSPNGRTRHRVRFNERVNVYSSNEIEPSIDGTPSPTKEEPWNDVLRGSDREAQFWSAHSGDMADAGVKLIRALSTPHSGDVKSSKEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W6QXR1</accession>
    <name>W6QXR1_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Xylose isomerase-like, TIM barrel domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S03g001041</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QXR1"/>
    <dbReference type="STRING" id="1365484.W6QXR1"/>
    <dbReference type="OMA" id="HPFYNAE"/>
    <dbReference type="OrthoDB" id="5360893at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.150">
        <property type="entry name" value="Divalent-metal-dependent TIM barrel enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050312">
        <property type="entry name" value="IolE/XylAMocC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12110">
        <property type="entry name" value="HYDROXYPYRUVATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12110:SF21">
        <property type="entry name" value="XYLOSE ISOMERASE-LIKE TIM BARREL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="Xylose isomerase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylose isomerase-like TIM barrel" evidence="1">
        <location>
            <begin position="38"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM34317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="358" mass="39854" checksum="97574A88248FD1BD" modified="2014-04-16" version="1">MPSLPNTIKSESDSRWKPAIATVSLGAAHLHPIVAKLDAAAWNGQQGLELFHDDIAQLAKTLRAHATDSALCTDRDFEIDAAHAIRDLSSERNLQVLALQPFRHYEGLIDQERHAERIDELKHWVQLCKILGDSVFILIPSSFLDASEITSDRERLAADLAEAADVAFPVRIAYEALAWGTYINTWEDSWDVIKRANRPNLGICLDTFNIAARLWADPTAATGRLGPSADRDLRNSMDRLVREIDPDRVLMVQLADGERVAPETPFLHAPGLPTLLAWSRNARLFPCEEDRGGYLPIREVTDACINGLGYTGWVSMEVFSRSTGEDNPAVPMEHAARASRSWWQVLEFLKEKSGKGSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W6QZ27</accession>
    <name>W6QZ27_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Bifunctional polymyxin resistance protein, ArnA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S03g001504</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QZ27"/>
    <dbReference type="STRING" id="1365484.W6QZ27"/>
    <dbReference type="OMA" id="FGHFRQV"/>
    <dbReference type="OrthoDB" id="16464at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05238">
        <property type="entry name" value="Gne_like_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050005">
        <property type="entry name" value="DenD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF043036">
        <property type="entry name" value="ErythonDh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43103:SF3">
        <property type="entry name" value="ADP-L-GLYCERO-D-MANNO-HEPTOSE-6-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43103">
        <property type="entry name" value="NUCLEOSIDE-DIPHOSPHATE-SUGAR EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="3">
        <location>
            <begin position="3"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM34777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="322" mass="35216" checksum="4450C9F127E6681F" modified="2014-04-16" version="1">MSILITGAGGYVGQELAASLLASTPATTTVTITDIVEPEIPESAAQYANRLRCVKADLTSTKEVDELISASNPYETVYILHGIMSGGSEANFELGIRVNLDATRYILDRLRKTVPGTKVVFTSSLAVYGLAPPGFVIDETNFPPVPSSSYGSQKLIIETLLNDYSRRGFLDGRCVRLPTVTVRAGKPTQAASSFASDIIREPFHGNKAILPVAKETEMWICSPHTVIKNLIHAREVPKEAFGDSRAVNLPGLKVSMQQMLDALLEVGGKERRDLVEEKYDAATDKLVQTWTPRFDTARAFELGFAADISMEENIRQFASRFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W6R059</accession>
    <name>W6R059_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ataxin-10 homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Copper transport protein 86</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PROQFM164_S04g000083</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">May play a role in the regulation of cytokinesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ataxin-10 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6R059"/>
    <dbReference type="STRING" id="1365484.W6R059"/>
    <dbReference type="OMA" id="FIMHNEH"/>
    <dbReference type="OrthoDB" id="379794at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051374">
        <property type="entry name" value="Ataxin-10/CTR86_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019156">
        <property type="entry name" value="Ataxin-10_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13255">
        <property type="entry name" value="ATAXIN-10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13255:SF0">
        <property type="entry name" value="ATAXIN-10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09759">
        <property type="entry name" value="Atx10homo_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ataxin-10" evidence="8">
        <location>
            <begin position="845"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="347"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="412"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="452"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="773"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="354"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="424"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="452"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="484"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00044801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF09759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM35202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="953" mass="106848" checksum="E0B15BA732E84E64" modified="2014-04-16" version="1">MADPKPLCTPAELMLKVILAGTLSHYEVRGMIDDKRLEHMLAAGKQILYKTHQESDVRHNLGMSPDIWQGLTNVLTKAIPVLESQSFAWKSPAASYEHSSANLIAYNYFSLVKDIERLNDLCTIARNLLATTKKAQNLAAETGFDQRILALIDTCVRVTARGFDGEQNARNEERWQKVVNLYKRLLITCLQYLHNFIMHNEHRKMVLWLDLFGYHSTADTNIIKPKEPLDDASSREGVAPIVQVGERVINPPIRALYDQTAEDLLLETIAKFPREPATIKEEAAMLLLANIKDHMERILGRDLSAIQEMGRDPDQVKDIRAALTAILGAKVDGWSDLQDRARELPAALPEEEHEDPKGHEDQAHDDHREHDEEEEEHEITKKKTILTIDRSLTAGFPRLCWADLPEINDFGAVDGPVTDEDTSMPRSAQSAAETLQEAKDELMARLQEPSHIDGDEEHDYDHGDSHTVGDDDSHSLDHMADGSVDGDGEDDVDDDGVDGEADDEEEEDDEYRGRPGDQQRGLLTDIPLVLGPAEIEALPMIVQAGIVDSFGLKGGERNGSRNMQALRCHILLTQETGRNLLRELLIFIAAWDLPDDELYFKMMAQIMEAVLKNGLMSHAYSDFGQPKDIISPAQAVVIKILTHIFRAKYSPASVTGSAQPNIPRNPSSLNRVDILTVRYIFTIFRGNIIPETCALIYLQGQIRAERALSEDFPLNLWDMERVYEGVYQFLEFFAVLTENNDWKNLLVKWEIVYDLVTLIKELEASIPKGQLSQLSFGSVPPPPPPRNDTANDASDASPPAPVAVERPYDPSDPDPADNSADSVDSRPESPPITEDPSEFEWRNLKKLVVLVLSSLVWKCPDVQEQIRRYGGVEAILCCTAFDAHNPYIKEHAVMCLKFLLEGNRENQRLVEELEAREVVNNDGGVLERSGYEAMINQAGKLAIRSKARAEEIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2024-10-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>W6R070</accession>
    <name>W6R070_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S04</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S04g000093</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6R070"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM35212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="59" mass="6615" checksum="BECBE4FFF3E56EFA" modified="2014-04-16" version="1">MSMVKRANAHGRPSAIWKASGRTIRLADEFQRKPSTAERSSLTDALTEAQPNWQLGLYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W6R438</accession>
    <name>W6R438_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Probable transposable element</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S05g000400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6R438"/>
    <dbReference type="STRING" id="1365484.W6R438"/>
    <dbReference type="OMA" id="HAPTEIR"/>
    <dbReference type="OrthoDB" id="4352260at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14529">
        <property type="entry name" value="Exo_endo_phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="1">
        <location>
            <begin position="87"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM36567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="320" mass="36407" checksum="65FF5029189419FB" modified="2014-04-16" version="1">MEALINDHQTQNLDVLLIQEPSITTYQTHVNHSAWRLYRPTPETGADRFRSLIYVNKRISTSSHRQILCNHPDIAAVKIWTADTQLLLFSVYIPSVPLGTPDSASPEPAFTAIQNTITAALRDGRRPTSIVLAGDFNRHHPTWGGNYIQPRLIEEASDLIDFSKPTTSTALDHRSDSTNNPELLVKCHLYHENYGSDHRATYSEWNIQPQNKPNNKARKVYDRADWARIGEEVARQTGPWKGIKTRPGLDRVVEKLISATAQAVDQLTPDTRPTPYSKRWFTPDLKVQQVEGNQLRRRWQASCAELGREHVNTITAFQLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W6R469</accession>
    <name>W6R469_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="7">High mobility group, superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PROQFM164_S05g000435</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6R469"/>
    <dbReference type="STRING" id="1365484.W6R469"/>
    <dbReference type="OMA" id="CAGPDVT"/>
    <dbReference type="OrthoDB" id="6247875at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01389">
        <property type="entry name" value="HMG-box_ROX1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.30.10:FF:000041">
        <property type="entry name" value="HMG box family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050140">
        <property type="entry name" value="SRY-related_HMG-box_TF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10270:SF320">
        <property type="entry name" value="BOX TRANSCRIPTIONAL REGULATOR, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G10820)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10270">
        <property type="entry name" value="SOX TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HMG box" evidence="6">
        <location>
            <begin position="133"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="4">
        <location>
            <begin position="133"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="187"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="527"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="103"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="213"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="274"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="363"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM36602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="685" mass="76061" checksum="AD0472A4E802AD0F" modified="2014-04-16" version="1">MSYDRVLPNPVALRYESAQVSLPRPSNLLDHKVMNEELPKSVMAMRHPDGAVRYADPRSTGIHQTHQHISKEAHRMSSNGPGKPVGPMISTKELPLRERSDRSSSSSASSTSPVKSHKESALQFCLCQPDPKIPRPRNAFILYRQHYQAMVVAHNPGLANPEISKIIGEQWRSLSEEDKSKWKALAEEEKARHQQQYPDYRYQPRRYGRDGSARSSATGIGHNPSGSSHCNRCGGRLMNAPASPMTPFTPSSGPGFRPSNFSPHPSSMPPRSVQGREKDPSPPKSAKMDHDPRSRQRHWEEPGGRSPDNKRRRVSQASFKPTLHPYRDHSPGNGVPESPHPMTPWSARPEMPPRHLPMLQPQRPYQSVQGQSHPDPSLKLPPLQTTTPVMTPMTPYPQEGSSVEATVMTIPFLNKIKVLAKISPPLLPSFRDGIPPARGPVIAVDGQDPDLVQAAVEYLNNLLKKETKYHVRVFDGPEIKAPRPTSAEAGQMGDATVDYLNTISAWHRISDEVVNFVKPTSRAGSVDARSITTDEETPVPNVSPRTLIPKTANMHIHSPVLSSENGSEVSALTSASHYSVPIALVPRYQLTTADAFACSTPIGDSYAPLDHWQWMASLWRACVGPDITVYIRECSKEELDRMGGNPVEVRLQDVRTVVLRKVAGRDLEEKALKRMGFEIEDFLTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W6R4F7</accession>
    <name>W6R4F7_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S05g000535</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6R4F7"/>
    <dbReference type="STRING" id="1365484.W6R4F7"/>
    <dbReference type="OMA" id="ARIYNPG"/>
    <dbReference type="OrthoDB" id="3353407at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021822">
        <property type="entry name" value="DUF3405"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36205:SF4">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36205">
        <property type="entry name" value="CHROMOSOME 19, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11885">
        <property type="entry name" value="DUF3405"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="260"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM36702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="697" mass="80563" checksum="4091B994D5CE5508" modified="2014-04-16" version="1">MKLLKRNRTPSPFYIKSSVSPRDRRWIWLRWLGYLTCLVAVVQTSSYLFGYPETNIIQTVYASLQGPGVLRPGQYHGNVGLWDKIAGDHSPEPDAFGMAHDRRDKRFYQGGTLTLTSIESVNASHPVPLVYDPYPAYNSREWKKRFYGRFQPCLGPRGRNLNRRSAEDMMQVYKGQQAGFPAARFGSYEALGLDENVCTDRYSRYGAYGYDDDGEDEIPGFTRPPSIPWCEVDWHRLQNLCLERNADRYESIATANSSNQSPLAFDLPQDSLKSRESPAGASGVKQYHPRSAVLIRAWNGLNWKPHHREYLRALIMELSLHSGGEYQIYLLCHVKEDEMPIFSDIKTINRLRNAIPKEFRNMALFFNNKLLEAWYPKIEEHSPQLQHHQPLQIFSQLYPHFDYYWQLEMDGRHTGHIYQFLDKAVSFARQQPRKYLWERNAYFYTPGAHGNWSEFKQMVHDSLSDRSNLTIWGPVSGTGIRPMGPVPPVPSPDYDNYTWGVGEEADFITFLPTFNPQGTQWTFPDKVWNFRYGQYTPRRAAVITMGRYSKRLLDLIHNAQATKGLGLASEMTGVSWALFHGLKAVHVPHPIYADGQWTPKELARIYNPGPPENVNGAPDSIWNFDHMFDHIMYRLSYMFTTHSAEDLYRRWLGYRTAEHEGGKTISEDRYGRHCFPSMFLHTIKNTAPQMGPDRAVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W6R6N5</accession>
    <name>W6R6N5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S06g000454</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the aldo/keto reductase family. Aldo/keto reductase 2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG792020">
        <property type="protein sequence ID" value="CDM37492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6R6N5"/>
    <dbReference type="STRING" id="1365484.W6R6N5"/>
    <dbReference type="OMA" id="ERIEMVW"/>
    <dbReference type="OrthoDB" id="48988at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19075">
        <property type="entry name" value="AKR_AKR7A1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050523">
        <property type="entry name" value="AKR_Detox_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364:SF4">
        <property type="entry name" value="NAD(P)-LINKED OXIDOREDUCTASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364">
        <property type="entry name" value="NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="3">
        <location>
            <begin position="7"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM37492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="322" mass="35619" checksum="36916C91B992412F" modified="2014-04-16" version="1">MADKQVKVVYGGALLGASSDFSTPAQVEEVLRVLEENGVKDIDTAQIYRGSEELLGQTGAASRFIVDTKHAGGFVPGTSSKELVIERANESLRKLNTNSVNIFYLHAPDRKVPLEETLAAINELYQAHKFHYFGLSNFRADEVEEVIRICKEKGYVLPSVYQGNYNAISRLIETELFPVLRRHNIRFYAYSPIAGGFLTKSKEALLNGGQGRWDSSTPIGQLYNRLYNTPSLLEALDLWDQLSKDSGVSKAELAYRWVAFHSQIQSALGDAVVVGASSVSQLKNTLAILRKGSLEEGVVRRIDGIWETIKDDAVLDNFNASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W6R717</accession>
    <name>W6R717_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Fcf2 pre-rRNA processing</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PROQFM164_S06g000599</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792020">
        <property type="protein sequence ID" value="CDM37637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6R717"/>
    <dbReference type="STRING" id="1365484.W6R717"/>
    <dbReference type="OMA" id="MELPTHQ"/>
    <dbReference type="OrthoDB" id="427886at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039883">
        <property type="entry name" value="Fcf2/DNTTIP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014810">
        <property type="entry name" value="Fcf2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21686">
        <property type="entry name" value="DEOXYNUCLEOTIDYLTRANSFERASE TERMINAL-INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21686:SF12">
        <property type="entry name" value="DEOXYNUCLEOTIDYLTRANSFERASE TERMINAL-INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08698">
        <property type="entry name" value="Fcf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fcf2 pre-rRNA processing C-terminal" evidence="4">
        <location>
            <begin position="99"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="196"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDM37637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="221" mass="25121" checksum="2A308A4CC6EC9996" modified="2014-04-16" version="1">MADSTFVSDVQEDLTDDQIQQLLLEAETRLKGLNAPSTQIDDLASLRIPKLSPGSSLESYIVQGDDVATVDAAKITDQKQKELANSLRTVEIKKANTDKPTAGPEWFNLPKTEMTPELKRDLQLIRMRSVLDPKRHYKKENGKAKPPEYSQVGTIIEGPTEFFSNRITKKDRKKNFVDETLALERGTKRFESKYRDIQASKSSGKKSFYKDLKAKRTRKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W6R933</accession>
    <name>W6R933_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S11g000050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792025">
        <property type="protein sequence ID" value="CDM38347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6R933"/>
    <dbReference type="STRING" id="1365484.W6R933"/>
    <dbReference type="OrthoDB" id="4364812at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM38347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="92" mass="10487" checksum="4880335643FEABE7" modified="2014-04-16" version="1">MPFDSAQIVCPLSHCVHTIPEADERPEHDELMNTWIDIDPFEAESRWAVPDNADHFNFGPDWRCVYNVLAEIAAPLSPGVEDKWIPRFRGPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W6PQ05</accession>
    <name>W6PQ05_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Probable transposable element</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S01g000057</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PQ05"/>
    <dbReference type="STRING" id="1365484.W6PQ05"/>
    <dbReference type="OrthoDB" id="4207519at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="2">
        <location>
            <begin position="9"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM26248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="156" mass="18005" checksum="7A72EC6A0A00190A" modified="2014-04-16" version="1">MKGIPNLYEARGTGQKFTQLEEKSIQDWLISMGQRGAALTIAMLKDMANLLLEHCGDDTLQTVGKNWPTQYIKRHPELTTRFSRKYDYKRALTKRKHRLLVLNGHNSHLTATFDKICQENNIILIYMSLYASHPLRLLDVGRFAVLKRVYGSRVAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W6PRF0</accession>
    <name>W6PRF0_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S01g000264</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PRF0"/>
    <dbReference type="OMA" id="RMCNDLV"/>
    <dbReference type="OrthoDB" id="4307606at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM26455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="267" mass="29629" checksum="45C9943F4D3E6C1B" modified="2014-04-16" version="1">MAHINQARVSAFRKARDNLVTLLEQQSTFLRHDIDSRAYVIPNLRLQLIQHIDIVASLSRKMAVESRHHPYVLVQQSGFYETVVPMHCAAIKGQCAYLADRLRDNLCTDVPIAIGSGIGLSLTTGLFIVYSTYRLSYDAMAIMPPRPGPVSAFKRERATFVSGLGMQARVLRADPQAYEDVSESLRELVTSVHRIKDTSMAMAVDARGNAYVLAKPYGFYSHNVPFMCNDLIASLLHWADILVNTDGRRTDGIVVDSIEGTLASLGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W6PRS6</accession>
    <name>W6PRS6_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S01g000265</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PRS6"/>
    <dbReference type="OMA" id="ADKVKWA"/>
    <dbReference type="OrthoDB" id="4331777at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM26456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="139" mass="15765" checksum="88569CA6A04DF54D" modified="2014-04-16" version="1">MPESIGTRLFRGTRAIFKYRKERGILVNNIRSYIATLRQMPEGNYLIEVALNIQSLKVQADKVKWASQALAVDAADMKYVTSQGIAHFTCTIPQICDMVGRDTLQMAKILHDHIHRPIINTEHEIALHLEHALANLGYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W6PSB8</accession>
    <name>W6PSB8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">LisH dimerisation motif</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g000932</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PSB8"/>
    <dbReference type="STRING" id="1365484.W6PSB8"/>
    <dbReference type="OMA" id="MKVIIVR"/>
    <dbReference type="OrthoDB" id="1932312at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM27123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="493" mass="53898" checksum="92CAC6BF385C9BDB" modified="2014-04-16" version="1">MATSRTIDALASAIVARFLRNNDYSETLKAFIREADLAPDVGQTSGDDTNNWTIQSLLEEKSTYDQTVNFERYGKGNQQSTLWSEPAPSRPSIIQTPTSSNILAASVEQWQKPRGDADQVAADAAPAQSYIVSTGADRQVHLLQTAEGNTAVKSFSGISDSPVLSVVSILQGQYILMTNMSGQLLLQHGSQTLDSRKDHAKYAVKVVVYKDKADPSKWWVATAGWDECVFLYCLNIPDEVDALSLTIGEPVARIKLNSNPDSLLFVPHVDTNELLLLVSRRDSTYIYYYQVEASEETDTRANDEPAAEKSPREARLLGQQNLAPHSNAWVAFSPVHMALSPHDPGLLAVATSTLPHLKVIIVRLLFPATTASEDPVTQASQALATLELQNREDAAILVQANTFSPQTAYSTPQVAWRPNGSGIWVNGDDGVVRGIETKTGKIIATLKGGHDSGFKVRTVWSGLVAVPQEEGDPVWEEWVISGGFDKRLIIWKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W6PSU4</accession>
    <name>W6PSU4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Zinc finger, AN1-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PROQFM164_S01g000605</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PSU4"/>
    <dbReference type="STRING" id="1365484.W6PSU4"/>
    <dbReference type="OMA" id="RQYCLKH"/>
    <dbReference type="OrthoDB" id="431929at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1110.10">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035896">
        <property type="entry name" value="AN1-like_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057358">
        <property type="entry name" value="UBL_ZFAND1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000058">
        <property type="entry name" value="Znf_AN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14677">
        <property type="entry name" value="ARSENITE INDUCUBLE RNA ASSOCIATED PROTEIN AIP-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14677:SF40">
        <property type="entry name" value="CDC48-ASSOCIATED UBIQUITIN-LIKE_ZINC FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25327">
        <property type="entry name" value="UBL_ZFAND1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01428">
        <property type="entry name" value="zf-AN1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00154">
        <property type="entry name" value="ZnF_AN1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118310">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51039">
        <property type="entry name" value="ZF_AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="AN1-type" evidence="6">
        <location>
            <begin position="29"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="69"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM26796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="321" mass="35743" checksum="023883457CEA8206" modified="2014-04-16" version="1">MPPITVSKGRSPSRDPNETFTQMADTDLESLGRHCQYEYCGQLDFLPFRCESCHSTFCLDHRTETAHQCPREGEWARRRNGRNNTSQENRTAPEKPSIYNTDQCAHTQCKTLINTLKDPAVRCPQCNHQYCLKHRLREEHECAKITPLGARQTNVASPNDTIKSMFARVRTWGRDKQQAAAKGTLLPALPKMKPKPNSPAARAVAVNGLKRSAKGDASVPAEKRLYLHAVGTAETQAAEPPAGDFFFDSRWKVGRVLDDAAKKLRVQNFNNRVDEENSRLRIFHVESGEFLEFSEAIGAGKVKQGDTIVLLRGAGAVLGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W6PT19</accession>
    <name>W6PT19_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S01g000695</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PT19"/>
    <dbReference type="STRING" id="1365484.W6PT19"/>
    <dbReference type="OMA" id="MSCCNEG"/>
    <dbReference type="OrthoDB" id="432281at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM26886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="335" mass="37754" checksum="EBDE461AF883189A" modified="2014-04-16" version="1">MDARSMPRIYINHLELVKNEAINSISIAFFRAYISYLLQNLIRVLTRLASFRQPSEGGIENMCHKKPLIPAMGNLSMFPAEIIFNILDELLASSPRLTHENFHAINQLTKTNRTLEQYIKLGWMGSNASNSFKQGVNTVQWYSNSDNANKALTLQGVDPQRIMPIEGPRGLGPDLITGIILADCTDCFEWFSEVLPATHMSCCNEGGWSFLSLALYARAEKLLDLFFLSGFPFEPRDFIIGSANAMGKGPSILGLAASSRDHQSFSRLFRKLKEVLNGHGFQRTLRDRLTGKERAAIRSVAPQYLQKMLYEAGLVTMHPALRYSPYYSGKRTLMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>W6PTC0</accession>
    <name>W6PTC0_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">U3 small nucleolar ribonucleoprotein protein IMP3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">U3 small nucleolar ribonucleoprotein protein imp3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">IMP3</name>
        <name evidence="13" type="ORF">PROQFM164_S01g000815</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uS4 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PTC0"/>
    <dbReference type="STRING" id="1365484.W6PTC0"/>
    <dbReference type="OMA" id="FRIKHEQ"/>
    <dbReference type="OrthoDB" id="10248812at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034457">
        <property type="term" value="C:Mpp10 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.290.10:FF:000006">
        <property type="entry name" value="U3 small nucleolar ribonucleoprotein IMP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="entry name" value="RNA-binding S4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022801">
        <property type="entry name" value="Ribosomal_uS4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001912">
        <property type="entry name" value="Ribosomal_uS4_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831">
        <property type="entry name" value="30S 40S RIBOSOMAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831:SF1">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN IMP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00163">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01390">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55174">
        <property type="entry name" value="Alpha-L RNA-binding motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS4 N-terminal" evidence="12">
        <location>
            <begin position="4"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="RNA-binding S4" evidence="11">
        <location>
            <begin position="114"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00069727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00072223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDM27006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="188" mass="22163" checksum="33605D887E9AC769" modified="2014-04-16" version="1">MVRELKHHEKKLLRKVDFHNYKSDGNHREHEIRQRYLLQDPMDYRKYNALCGSLRQLAHKLSQLDPDADPLRKKLESELLEKLWRMGILKQSREQGAGLSKVERDVTVSALCRRRLAVFMVRSGMVETIKAATTFIEQGHVRVGTEVVNDPAFLVTRNMEDFVTWVDSSKIKRNILRYREKLDDFDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W6PTI1</accession>
    <name>W6PTI1_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PROQFM164_S01g001324</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="2"/>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PTI1"/>
    <dbReference type="STRING" id="1365484.W6PTI1"/>
    <dbReference type="OrthoDB" id="629492at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071218">
        <property type="term" value="P:cellular response to misfolded protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045862">
        <property type="term" value="P:positive regulation of proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46803">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE CHIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46803:SF2">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE CHIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13414">
        <property type="entry name" value="TPR_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="repeat" description="TPR" evidence="6">
        <location>
            <begin position="2"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM27513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="173" mass="19177" checksum="9B9E093448E4CAF2" modified="2014-04-16" version="1">MAQELKAKGNELYKSGDYSGAEDLYSQAIQKNPSDPTFFTNRAITRSKLAKWADVEHDARAAIEIYGLKNPVALKSYYYLAQALLGLQRPQEALDVASEAYQQSLAAKNAQSENLSQTVLRAKQQIWAARETSRVRQLNETLGSMEALIEADVTRALAELQGRLERGEIGEIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2024-10-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W6PTY1</accession>
    <name>W6PTY1_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g001484</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PTY1"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM27673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="59" mass="6826" checksum="E2B766E4B3FF6558" modified="2014-04-16" version="1">MWYRLFTPSPHMYGLNGKLLRTLDDVGDDAVRRASFLSKDSGSPPEPHSTRRAIQWRTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W6PU78</accession>
    <name>W6PU78_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type DNA-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PROQFM164_S01g001120</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CDM27311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
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        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
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        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GAL4"/>
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    </dbReference>
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        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="146"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="197"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="45"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="63"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="81"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="403"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM27311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="425" mass="46106" checksum="08FB8EDDE87A7D29" modified="2014-04-16" version="1">MSGNPNDHDPSRQGDPNRQDPRDPRDHRDPRATQWNSPDDQVSYPYPPTSYPPPPDQDRAYQYPPPAQYAPSQYPPPPQYAPSQYSPAQYPDPRYPHPQAMNAIHGAQDPYRLPPPPGPYRADAYGPQTGQGPYQAAAPRQRTAIACRYCRRRKIRCSGFETSADGRCSNCVRFNQDCMFTPVSSQTQAFVPAHTAYPHLRPGQNGSGGRGGPPVLYGAHGQPLPPQQQPQAPETTLPPPQGMYYQNGRPFMDGVPLPLASTMPDPRHRRGSNSGFEYPDPTNLAPVTPAGSAPGYQTHTTPSPYAYPPPPIHDRRTSPPSAYNYDPRPSSSPHGSPFPPMQPHQAPMTPHQGSIPPVSAQQGSVPIKSSGTPQPGGVTPPPTSTPGGSQRGGLNVRDMLNPGDSQGRSSTDSDMLNALNRRGPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W6PV00</accession>
    <name>W6PV00_PENRF</name>
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        <submittedName>
            <fullName evidence="10">Zinc finger C2H2-type/integrase DNA-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PROQFM164_S01g001427</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1365484.W6PV00"/>
    <dbReference type="OMA" id="ANDGYIN"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="VerF-like"/>
    </dbReference>
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        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
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        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RFEC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="215"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="269"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="399"/>
            <end position="424"/>
        </location>
    </feature>
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        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="48"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="110"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
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            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="289"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDM27616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="470" mass="50373" checksum="D879DDB96D3C8AD6" modified="2014-04-16" version="1">MDPRSHPSRPPSTSLPPGSTPMSSTPISSMHIPQYSMQPQYPVSQPHTLPPLQPHHPQSPAPHHYMGQPYRPDLSRYPPSTHDVYGASQAPMMPHTTAHQQYPPPPSVLPPASSAQSYPQPIAPAPPRDRRPDFNGLPSGAFSYSDGKGWGMTPDVNGANGSPYAKEPPRTQVVGSQGRRGILPSVPGRATPVSNGVNGTAKSTTIPAKDADGKFPCPHCNKTYLHAKHLKRHLLRHTGDRPYMCVLCKDTFSRSDILKRHFQKCSIRRGNPTGATHLSHPQAHLKRSQQQAAAAAAANPPKPLQDEVSNPVPHSNGVMGTQYDGAVNGNGMATGRPSYAEQQPLGFTMQSVNGMNRGPGDDAFSAGQAHARASWMAGPKQNPYLMQPGVDAHGQQLTGDRPLEQHGSSDGYINPGFPHSMAAGQEPIHAPVDHDRKYYPASTGPESGMNGLYLASTTLSGDGNVQPARQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2024-10-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>W6PVE6</accession>
    <name>W6PVE6_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S01g002029</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PVE6"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM28218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="54" mass="5934" checksum="2466FB6F761BDEC0" modified="2014-04-16" version="1">MDFPLVIGISILASVSISVSERFHPIRPFAFELITSSDRDIPPGGISVPVWRLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W6PWF4</accession>
    <name>W6PWF4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Probable transposable element</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S01g000063</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PWF4"/>
    <dbReference type="OMA" id="THTKIRW"/>
    <dbReference type="OrthoDB" id="5243754at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM26254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="135" mass="15336" checksum="0118AEC64803CFAA" modified="2014-04-16" version="1">MKRLRRNGTHTKIRWIPTSDDNKLRGLAKEQARAATKEDALPQERVPRMKPTTLNIARLQGISSDKLPVNAGRHAKQKEANVLAQLRTGMAGINGYLHQINVADTDQRACGQARETVEHFLSRCQKWTAHWTEFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W6PWL1</accession>
    <name>W6PWL1_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein efr3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">efr3</name>
        <name evidence="3" type="ORF">PROQFM164_S01g002111</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EFR3 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PWL1"/>
    <dbReference type="STRING" id="1365484.W6PWL1"/>
    <dbReference type="OMA" id="ATHVYYT"/>
    <dbReference type="OrthoDB" id="19232at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039786">
        <property type="entry name" value="EFR3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049150">
        <property type="entry name" value="EFR3_HEAT-like_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47766">
        <property type="entry name" value="PROTEIN EFR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47766:SF1">
        <property type="entry name" value="PROTEIN EFR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21072">
        <property type="entry name" value="EFR3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="474"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="601"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="857"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1018"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1106"/>
            <end position="1147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="479"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="601"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="860"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="898"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="929"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="945"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1108"/>
            <end position="1118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1124"/>
            <end position="1139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM28300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="1147" mass="125919" checksum="561D256AA94C8A09" modified="2014-04-16" version="1">MESVRQSCRPKHQVLTLKCYPKYQKGVSEVRPNSSELSYLLYYTSTRRSKLTKVCGFLEKRVARDVWRRRIGNVQVALHILAAIIEKVPRDLPIYARSVMTVIDTILRSNDINMVEESIVTFEMFCRYQDIAAIAADQSLAHQYREVVRTYTGLADPGFTSNANTDFSPQVAIRWRNAGLRAIRAVVSSETLTADGGTLLKLCLPVILKNLYSEDENLLITLKEKLSETEANEREPPKPRRMSVNTVHTVDVAEGDPELAAQSAAEADRKAEMDARVLALRCLEQTIASGSNRGQIRIVVTVILQFISRKGFPQSEKRGEITEGKCGNWATSLIDLIANWCPVQVRFIILITAMEILHDTTPKEDALQSSFTILSVVDSLLKSSVNMIGLSVMDVLYGLMHYASEILSPSERTGSADGEKKNRQAEIVVQISPQRQDLLTLLEQSIGDLATHIYYGDQVEDMMRAILRRFKPHLHHDSSSPSTLATVQESGVTHEATSDEPETNGDKASTETFSHAAAKLTALRAVKAILVVANSKTLATMSGVESRHSVGIHVWEGTQVLLRDVDRDVRYAYSDAFLSWLQIETNGNDLKVRLDSPKYIKTPKKDTEQMDRPTRRGSSVPATQRDKVALVAQSNFLRLLHLAIYDAAIEAATEEAEILLLHLLLANLVENLGVNAAQFGVPMVFKLQDDLFTSMDLSSFAARVNIGSLVHGYLLALSQHFDIQSSPVGQEISNEIQQRQAKGYWLSKIRLPPVDLHAIVFDSEKRSDNDSTSPPLLTPFCNVEGLVYMIEESYCKLVSSPPERPSSASSPARGFTFPVLGSTATVKSQVESHLPSVVKEQMLSPWSREACLAAVDKESTGTPSVSGSRATTNPRYNQTNMATNGSPAGSQYNRRMSIPEISGSSSNSSSRSSPVRVNELRRVLSVTSDSHDRRLSPLRGRLDASNDSSVSSGSESMMSGNFSVSEIDGDATSIRPESQRTPDDDGLETPRATPAAFFLSGDKAEDIPPVPPVPTGLSIPGGFPNDSQRSLASYDRPFTAPAPSGPPARDRADANALNYKPLNRNKSRSNHSLATSGIPELLTDYETNDLNGNHQDQLRKLLDGFLSPNENKLTNGSRPATAISASKALPSRSSSTRRSGGLGRPPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W6PWT3</accession>
    <name>W6PWT3_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S01g000228</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PWT3"/>
    <dbReference type="STRING" id="1365484.W6PWT3"/>
    <dbReference type="OMA" id="FTHAIDS"/>
    <dbReference type="OrthoDB" id="4045395at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd11693">
        <property type="entry name" value="HRI1_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.320">
        <property type="entry name" value="Protein HRI1, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031818">
        <property type="entry name" value="Hri1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043047">
        <property type="entry name" value="Hri1_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16815">
        <property type="entry name" value="HRI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM26419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="258" mass="28700" checksum="BA210B184193F344" modified="2014-04-16" version="1">MVNKPNQSTCRFSKRISFRWLTTPAEETTDTIVMSVKDWYVDLRIETATGKIDWAIAGQRIVEGQEPLRVTFSHELDSHNAFEIADCGSFFPLPNGDDLEVGSMPRHDLPGAPDKEYEEVWRELPFREGPEGPNKGISWVLESDDGDLGSGEGEVTVSKTFIGRIWGTYLALSQTQIHSRQKTPSGDLVVKKSGADVSARREEWESGWNEKYLVGEAAGSLPSMVVGFDGEGVGSWRTPGEKVEVQGKTYIVRAFEEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W6PXD7</accession>
    <name>W6PXD7_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">3-hydroxyisobutyryl-CoA hydrolase</fullName>
            <ecNumber evidence="3">3.1.2.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">3-hydroxyisobutyryl-coenzyme A hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">HIBCH</name>
        <name evidence="8" type="ORF">PROQFM164_S01g002694</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>3-hydroxy-2-methylpropanoyl-CoA + H2O = 3-hydroxy-2-methylpropanoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20888"/>
            <dbReference type="ChEBI" id="CHEBI:11805"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57340"/>
            <dbReference type="EC" id="3.1.2.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.1.2.4" evidence="3"/>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PXD7"/>
    <dbReference type="STRING" id="1365484.W6PXD7"/>
    <dbReference type="OMA" id="EVFTMEY"/>
    <dbReference type="OrthoDB" id="1737613at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003860">
        <property type="term" value="F:3-hydroxyisobutyryl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006574">
        <property type="term" value="P:L-valine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000026">
        <property type="entry name" value="3-hydroxyisobutyryl-CoA hydrolase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045004">
        <property type="entry name" value="ECH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032259">
        <property type="entry name" value="HIBYL-CoA-H"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004127">
        <property type="entry name" value="PRK05617.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43176:SF3">
        <property type="entry name" value="3-HYDROXYISOBUTYRYL-COA HYDROLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43176">
        <property type="entry name" value="3-HYDROXYISOBUTYRYL-COA HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16113">
        <property type="entry name" value="ECH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl-CoA hydratase/isomerase" evidence="7">
        <location>
            <begin position="66"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM28883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="494" mass="55485" checksum="5BB4AC67E863DB16" modified="2014-04-16" version="1">MLLRQFNRVSSPSWISRVPSAMPLRAKVTNPAFRATAMMSTSSDIPKELPGDERDDVLFNSIYGLRSVELNRPKKLNSLNGSMARKIVPRLKEWEKSHLANMILISGAGTKALCAGGDVAALALQNESGVEGQKASADFFALEYRLDHLLATYSKPVISFMDGITMGGGVGLSMHAPFRIATERTLFAMPETTIGFFPDVGGSFFLPRLDGETGTYLALTSERLKGVQALYAGIATHYLHSSVLSSVTQRLSELTFPDHVELRERLEIVNKTMAEFSLGLPPLEEEPMLMAGTLRTAIDRCFGFNTMEEIIQALEKETEHKEWAQKTLETLSGRSPTSLKVTLRQMRLGKKWTITETFQREHEIAAKFMRHPDFVEGVKARLMSKPPRQAQWQPATLQDVSDKIVDDFFEIPDNESRLPLLSQGDYTKYPYAHFALPSEDEIKKVVCEGHSSRRPVIDYFLQKYAHREGVRRKVVEVIARRTTTSSPEGLKWLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W6PXI5</accession>
    <name>W6PXI5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g002471</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PXI5"/>
    <dbReference type="STRING" id="1365484.W6PXI5"/>
    <dbReference type="OMA" id="YKYLHAP"/>
    <dbReference type="OrthoDB" id="5378502at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="459"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="605"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="617"/>
            <end position="628"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM28660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="646" mass="72880" checksum="9B23DE57D4B32458" modified="2014-04-16" version="1">MSRMRLRDSIRAPVRYGEDEYEASRVSLRQGCDDSIDDSMELGETGKPRPQQGRKPNTVPFNPNLPPAAFPTLNIPQPGRGSSVSAHNRGVGGSRQNVHASEATSAFRNDRSVPSPPSGNEELSMDDIDNHLASNNMDNPVYARNVNLARMSVDAFPGSEDIDMDMATSPDSDDDPLPDATQVLLDTIPNPKWGDLHKAMQVEIIENIMKFHSWRRVCDLLGLGLVERRQLMINIGIRNKQIERENEILEKMRHKQRRALMRIDNSDLKLFKPPPQLVLKRITREAHQNLLVTGYTDLLMCQSHEFLKARQFLHQHGLPRRYAGDWGDSLVVLRESGEHSHEPDEFEWKENLRVTPPPDETEDIINPFMDPASRAKSQFIQSIGMHGTINPRDLIKRDTDPAPIVDWGKYYKRKPDLSWDTTKPQLNGLVKVKVGPHNAARIQHCTDAGVELQGLSSQTQVTAMPGSLPQGSLQDTPSKEPRNASLAQPFFRRPARPFRRVLTDWSSPVPHQSESQSKYRRDIQQAKLEKLEAKAEGLRRRYNYQPNLQVKGVGVGISPARGIIQMMPPMQPVEEETHSKLFARTHRGMTNMNIDRLMDEFIELPEESEPELPDAKPTSTDISSTTEVSMDDVMLVPTDGCSSSPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W6PXS1</accession>
    <name>W6PXS1_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g002854</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PXS1"/>
    <dbReference type="STRING" id="1365484.W6PXS1"/>
    <dbReference type="OMA" id="VQFPFIT"/>
    <dbReference type="OrthoDB" id="2101715at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM29043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="278" mass="32113" checksum="913AC09D70894549" modified="2014-04-16" version="1">MQLFSWPRSHLLEIGDQDWCPSWLHRHEQLVLTQLWNLRAPGWSHGNLAKQACVVFKEHLKDLSSYTVLDICAGAGGPTPVLESELNKELESEGKGPVHFVLSDLYPHIEEWERISKKQQNVTYIESAVDARAVPRFAESSKKECRIFNICFHHFGDEDAAGILKSAIETADSIFEITSRDLWTCLCSPLVFFWTFFVTLIWYWDSPVHLFFTFILPVAPLTIFVDGFISCLRTRTTKETWQLLDQPDLDLTNWTFHSGQKTVQFPFITLYYHVGIKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W6PXS4</accession>
    <name>W6PXS4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Rhodanese-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g000553</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PXS4"/>
    <dbReference type="STRING" id="1365484.W6PXS4"/>
    <dbReference type="OMA" id="MPALNML"/>
    <dbReference type="OrthoDB" id="10259545at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00158">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000058">
        <property type="entry name" value="Cysteine synthase B, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050214">
        <property type="entry name" value="Cys_Synth/Cystath_Beta-Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10314">
        <property type="entry name" value="CYSTATHIONINE BETA-SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="390"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM26744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="527" mass="58688" checksum="4FBEB32307157601" modified="2014-04-16" version="1">MVNSSEKITNMNEHNVYFGIDSLKKYFDPDCQPPLPLVELPPHLNPYHQDGVRIYAKMMTMHPTNNVKAMPALNMLESSVVPGETNRIIEYSSGSTVISMSMVARVMHGVNDTRAFLSNKTSDAKLKLMQFFGLDITLFGGPSQPEPLDERGGIQNARRMALESETIVNPNQYENNNNWQSHIRWTGPQIFKQLPEINVLCAGMGTSGTMTGLGTYFKDVKPSVYRLGVCTAPGDRVPGPRSYALMRPVEFPWRAAVDTIEEVGSAESYTLSLNLCREGLVCGPSSGFNLQGLFQTLAKRKAAGTLSELAGPDGTTHCVFLCCDLPYQYIDEYFQKLGEEQFHPIRNERLTKVDLHRYDESWERDALDVLPQFYGSPRSLAQSLLSEIVLKPQNHVLDLRQKNDFHAWHLPGSIHLPLSSVRPHSPSPFSDPGVLEAQWAELEKIFNDDVFVSDLRRHQILVVCYDGDSARVATSVLRAKGLEADSVRGGHRALRMYGIGNESPISVEKGPIKATVSVAAVPLEQRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W6PY52</accession>
    <name>W6PY52_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g002492</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PY52"/>
    <dbReference type="OrthoDB" id="4368319at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="631"/>
            <end position="671"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM28681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="789" mass="91302" checksum="2BC35B9F94785E4F" modified="2014-04-16" version="1">MSRIFLRTFQPSLNWVLLPPLSHCPHVRPDSYTKLNPISVGSTEYSVSFPSTMWRRDLEYAVRHMEKERNWDTSPSVSQGSQPSPVALLRICIRYKHLYTRLSSNLTFWFSVTDDFHAASGWHEERVRSFVQKKLSEYRYRDHTVRPVDPDGYRMESLLWEMMEHISFIKWRSELRRSDYRYRSPTPLPQSDLDMTWQDVEEAILERVKSAAMRCDFDQAKWLLLQFKDNQKPESYIKEFESNKSLHEQIEKQREMESAKAESDGEWEKAKSSLLSMENKVRSGRLLVALERRQAIQNKYNRSLQEETVLAQFVDRDLTKACDLVSLMKGKRPKALVALFKCNEALAKGDFSGAKSILSDPQLASVHMALEPIVDLAEALHNEDQDKATSLSLRLKVDGENFGRILLNSSAGVSTERCDGHVEVVSLLQPEEPLSDADIEFQKRSKEESLCGDWNEAKRLLLLIPKKTVSGPLLRKLEAERSAFDEADKDLEKQAKEAEMKGDWEGAKSLLSRIKSDFGKFLLAALAYSEARLTHKDEHMEILVQLQKKYPDARLEQVKFTQYFEHAERNGPPERATDLHSLFVGEKMFGTGVLWSEPDDFRKVFEMMAEDMRDTYDRAWYCLPAPTMRSPTASRSQAGEGHIAENPPSETTQVEPRGCPGTSPSSSSLPAIPRDPCIMTPNWTVIREYQRDRPELPSLSLDQQLVLFQICIVHKSRYTKSQGNLDFWHRVADQFWEVSGWHWKRVRTLMNYVPIYMPSVIRTEATWLNRVHGRQWFKAKQEDFLGKAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2024-10-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>W6PYD4</accession>
    <name>W6PYD4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S01g003080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PYD4"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM29268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="60" mass="6977" checksum="70C2616B946A5438" modified="2014-04-16" version="1">MKFRNVSLPQIETDLELCQVFEPQSRTPSPLYERIIGNFRTIVLRLNSMGLFLQTGDFTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>W6PYF9</accession>
    <name>W6PYF9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SMAD/FHA domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PROQFM164_S01g002572</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PYF9"/>
    <dbReference type="STRING" id="1365484.W6PYF9"/>
    <dbReference type="OMA" id="HYKSDKV"/>
    <dbReference type="OrthoDB" id="5402974at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060962">
        <property type="term" value="P:regulation of ribosomal protein gene transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045178">
        <property type="entry name" value="Fhl1/FHA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21712">
        <property type="entry name" value="PRE-RRNA-PROCESSING PROTEIN FHL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21712:SF29">
        <property type="entry name" value="PRE-RRNA-PROCESSING PROTEIN FHL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="5">
        <location>
            <begin position="426"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="Fork-head" evidence="6">
        <location>
            <begin position="719"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="3">
        <location>
            <begin position="719"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="305"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="515"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="799"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1002"/>
            <end position="1153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="48"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="313"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="545"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="595"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="808"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="822"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="835"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="865"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="898"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1005"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1031"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="1043"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1082"/>
            <end position="1093"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1094"/>
            <end position="1120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM28761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="1219" mass="131951" checksum="4443C079A63DFF02" modified="2014-04-16" version="1">MSSQTMTAPAVGHRPPDPGPDSPLYDYGCSPDTTPPSNPRDDSAIRAMQNNSAPSTPNGMPAPDVAIKTECSDSHDFSAAQHQQDVNTQSAASALLAQLLGNQSAANSTTMVQPAKQEEHQDTHIDIKMDDSISQPFDMAAQNPTPIDPSLHRDTTSISREIQDLLNGKALGDEQGNSAHQDMNHTEFNSTDAMETLSDPMNPKLNPEQPSLLPPLDFSAAPKNAFEALHQNEMLTAAFLSQNADLSALGYQDMAASIAGSEPKIQAFAKLEFDDGHFYVNTYSFILGRDVRAARAAHHREFQYRQAVRSTRAKSSSGGNTSHTPNRMKREESAAMMGSVVSDRGGIMGFDPDVPPHLPNNMNMSRRSSRSSFDEAVIPLHANPAQLQSTTDYNALAMQSLQDGNGDAKPVDALALLPSPDSCPTIPIHPPTTVDGSAAGHRGISRRHVRISYNFDRNLFEMEVMGRNGAFIGADWLSPGQVRPLHSGDYIQIGGVRIRFLLPDVPIGETGADRMEEKLAEKEEEEEEQDARASIEVDDEDDESDRLGSDSGESREPSKKIVLKTRDSKSSQAMDSIENGDNDSQPTRRRGPGRPPKDGIMSKRERAELAREQKNAAKREANGGITPPPPKVPKAGKTVAKESVVPESPKPSEKRKYTKRKKPDGTPMESPLPSTEGKVSVEPAQEYVKPPPVKKRKPSRSPSPNYPPESAYNTEDLAKPPYNYAVLIFDALTEAGTPMTLKQIYRALKLKYPYFRFKCETEGWTSSVRHNLNGNGHLFMHAERDGKGWSWQLIPGASVEKEKKRRPSPPPQVSHPPAPTPQQYMPQASYSYAPQGPPPVPNPPQHFQFPSIPPAPFPASVNVGGPPPRSSPYPPALKAPAPKPTAPPAAPVQATATAPPPPPAAAPAPVPAQAPPPAPTPAPVSAPIPPPAPTPTPAPIPVSAPAPAPAPTPAPTQAPAPVSAAPVPAPAPAINPAASFPIPSQLRNNLPAAFAATIPSTYTSPYASAPAPQGGQQQQLQTPRPPHGPPQHHSPYSQQKPPSSQPPHNNPQPRAYPPSGGVQFQHHQHPHPHQQPVPPQSQPMSHPPQQQHPLPHHQHQLQHQHQHQHQHQHQHQHQHHPPPGLPAHPHHQQQHPAQQTPGPPESSSFIDRANKAIDDFEAVLMEDYEDKNYIREVLRSARARVLGDAPESSFPGGEPKDEAVIMDVLRNLVGSLKDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W6PYK3</accession>
    <name>W6PYK3_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PROQFM164_S01g000853</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PYK3"/>
    <dbReference type="STRING" id="1365484.W6PYK3"/>
    <dbReference type="OMA" id="WHPLGVH"/>
    <dbReference type="OrthoDB" id="341482at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000056">
        <property type="term" value="P:ribosomal small subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037700">
        <property type="entry name" value="NUP88/NUP82"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13257:SF0">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13257">
        <property type="entry name" value="NUCLEOPORIN NUP84-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="6" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="821"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="687"/>
            <end position="762"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDM27044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="880" mass="96858" checksum="54B9C03A2D746ECB" modified="2014-04-16" version="1">MPKVNSYAPAWLCRPSPGAKFLSSSSAQSPGEDLQTGSKPMRNGATRTIAKRGNEVFAVVDNEIRWSNLARLKDQWQQEIKQKKGYASQAEEQIDLSQVPPYRVLAVPVYGQIKQIIPSPNGAFLAIVTEHTVHISVLPDSSHLSSSDSDSIRLKTYQLGPTTHVIPEAPVVSALWHPLGLHTNLGGCIVTVTADAAVRVWELDRNNHWSFDQPTLAIDLKKLVDGTSCDQDFAPSGFGKSKGFSADVIDMEVASACFAGNGNEKEDAWAPMTLWVAMRPGDLYALCPLLPFKWQAPSTTIPSLSAAIIPKLGALEQESQESEEELIACRQQYDWLSELDEQEPLDAPSGSRTIQGADVFTRPANPSAIPRLQGPFRFETGDELDDLDLCDLLVIAASLNVEDLMMGEEEELAVETGDQDKLSATVLSLTSGNGRVHICLELDGVEGQWLPKARKNAFQTPVSEPTELVLVESLDTIKDGEETTSWPTFTKDIHSRYSFFVTTATNVVFISLSGWVQRLEAELQAEDTAGSAFRLQVLCDGNVTNRERILQVSNADITAQNEHLATSLVFYDFDIGYLLLTYHPSNPYAVVMDTPEDSLSLALDKSLYEPRASAPGSLLLSPSRAPYQVPAIFYANSPLDSFVEKHVPHRQRHTLKEQVRLSPATLDLVATAHRVLSAHTNALERAASDLFRRCERLQGEMQDQLKQLADVAERVKGVTSEIGEDGHRKEGVRNGEALDKRLQAAQNKQSELNRRYEALRTKVLNSGGRPLSEREKAWIIEVKTLSASLQQGEEQEEDQPLISRLETVKRLALDLMAQTKSVAGKLPSPELGTPSSPGGPPKVPQRLQRAKVADAMRMVERESAVIDAITSRLERLNTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W6PYX7</accession>
    <name>W6PYX7_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">aldehyde dehydrogenase (NAD(+))</fullName>
            <ecNumber evidence="3">1.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PROQFM164_S01g000968</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>an aldehyde + NAD(+) + H2O = a carboxylate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:16185"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.3" evidence="3"/>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PYX7"/>
    <dbReference type="STRING" id="1365484.W6PYX7"/>
    <dbReference type="OMA" id="NHTPFTG"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000009">
        <property type="entry name" value="Aldehyde dehydrogenase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000007">
        <property type="entry name" value="NAD/NADP-dependent betaine aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="7">
        <location>
            <begin position="17"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00049194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM27159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="516" mass="55204" checksum="79B51272E42FD89A" modified="2014-04-16" version="1">MKYRLWLAGKEQDGNADLIPIEDPATGEIFAQCHAASPEDVETAISAAQAAYKSGVWSRASRHHRADVLEKCATLLSDSLPQLISTESKQTGRVIREMKAQVPSLTRWFKYYASLLRVEERSVLPTMGKLHNFVDRVPLGVVVQITPFNHPLLIAVKKLAPALAAGNSVIIKPSELTPLTTLLLGKILREAGIPDGVLSVLPGYGAITGKALVEHPLVKKVDVTGGTMAGRAIGRIVGGNLAKYTAELGGKAPLVVFEKANIDTAINGIVFGSFIASGQTCVASTRIIVQNSIMDELLHKLKAKIESITRRIGAPSNPESTMGPLISEKQLQNVERLVNSALDGGNAVALIGAKRMVSQSPLDGFNFERGYFYEPTLLASNNGNNSIVKTDVWREEAFGPVIVVAGFDTEEEAIALANDSEFGLGAGVWTLDLPQAFRVSEQIDAGITWVNTHHRNDPSSPWGGAKSASGVGSENGIEAYNAYTTSKSTIINYASPDESLAADDWFGDGSGNVRYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W6PZ12</accession>
    <name>W6PZ12_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g002782</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the caleosin family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PZ12"/>
    <dbReference type="STRING" id="1365484.W6PZ12"/>
    <dbReference type="OrthoDB" id="640742at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007736">
        <property type="entry name" value="Caleosin-related"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05042">
        <property type="entry name" value="Caleosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM28971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="53" mass="6112" checksum="CEEEF8B5FB0FC634" modified="2014-04-16" version="1">MPEGRFIPQLYENLFSKGESDGDGTQSFREFFQLMHGYRCAADPFGVSLQYGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W6PZW5</accession>
    <name>W6PZW5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glycosyl transferase, family 8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S01g001310</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PZW5"/>
    <dbReference type="STRING" id="1365484.W6PZW5"/>
    <dbReference type="OMA" id="WRRTDQT"/>
    <dbReference type="OrthoDB" id="2014201at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02537">
        <property type="entry name" value="GT8_Glycogenin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000171">
        <property type="entry name" value="Glycosyl transferase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002495">
        <property type="entry name" value="Glyco_trans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050587">
        <property type="entry name" value="GNT1/Glycosyltrans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11183">
        <property type="entry name" value="GLYCOGENIN SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01501">
        <property type="entry name" value="Glyco_transf_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM27499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="308" mass="34773" checksum="7D10C783BCE983C7" modified="2014-04-16" version="1">MDENILQPHASKVWTTLITNTAYLSGLLTLEYSLRKVGSKYPLVVLYTDTFPAEGHKALDSRKILKRHVPYLLPSAPKDFTNDVRFYDCWSKLTPFSLVEYERVVQLDSDMLVLKNMDELMDVELDSPEMAGNGDRVFAASHACSCNPLHKPHYPADWIPANCAYTTQHENPDIAQIAGASPTSGLGIPNGGLQVVIPAQATYEKILAQLGASTTSNYDFADQSLLGDLFYGRWVALPYIYNALKTLRWEGVHDAIWRDENVKNVHYILSPKPWDETGPSQDPSHAWWKTLNEKRLSEEQETGLRDEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q0E7</accession>
    <name>W6Q0E7_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g001500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1365484.W6Q0E7"/>
    <dbReference type="OMA" id="MGLFNKP"/>
    <dbReference type="OrthoDB" id="5335210at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="361"/>
            <end position="1174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="307"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="465"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="487"/>
            <end position="500"/>
        </location>
    </feature>
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            <begin position="501"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <begin position="554"/>
            <end position="567"/>
        </location>
    </feature>
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            <end position="590"/>
        </location>
    </feature>
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            <end position="606"/>
        </location>
    </feature>
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            <begin position="650"/>
            <end position="659"/>
        </location>
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        </location>
    </feature>
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    </feature>
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            <end position="789"/>
        </location>
    </feature>
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        <location>
            <begin position="844"/>
            <end position="855"/>
        </location>
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            <end position="891"/>
        </location>
    </feature>
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        <location>
            <begin position="1011"/>
            <end position="1025"/>
        </location>
    </feature>
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        <location>
            <begin position="1056"/>
            <end position="1070"/>
        </location>
    </feature>
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        <location>
            <begin position="1071"/>
            <end position="1080"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1114"/>
            <end position="1126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1157"/>
            <end position="1167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM27689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="1174" mass="125965" checksum="C02298C138617A40" modified="2014-04-16" version="1">MMNRFRKHKKAKEAAEEEATSPGFSLKSSKKKVVEPEPKLDFDLSAALPPTDNFRTSLLMPKLSARFSMLKEQDDPLSMLGKASDDSVLFPKRASRLNLFGHNPAMLTDIDEVCSNDGSRPSFALDRTSFASGGDGYGTDDDRSQTGSMMSRARPAEGNNLFGGRQKIYKIPVRSPAATTPDTPDAGRWGMGKPVYEHDLNLSAFQRLRLKEKEERAEAAAARESGYAASTASSNSRLTYSSTASGPLSTVPTSTVGTSADESPLTTSQAPATGYPFPETLPEDSRPGPGPMSGPRNGSVRSRRLYGQGLTQAAQSQQSSTLNRLESLSRQRAGTPDIPSLNRNFSKSATNLRDHLKLAIVEPASTTGPTSPPPSATSSKPRMSGEAGFKDHLSPSTATFGAPPLSPPTSENNDVPSLLAASINPDDHGKATAMGLFHRPATGFDEQAFSRRQLQMHQGRETPPPRRASPPRRPLPAEPVGRARGLSKSSYRSTAESASSHYSIDPSSSVEASPFRPGVRTFYANSSASESGDDGERPSSRELSSLASEYGPPLQQSSVGSNKPSTSTKDHLETLPEVRYSDLGDLRPIDEDGLDFTISSPVVSDNTPKRPDSPTLEPDQGFGGMGGLVRSHLRQESEMSSIFPPPSPRSSEHQNDKLFPKTGTPQPPNGLPTITQTRDESRSSSRTRPGTSSSRSPSGHSVEGAGSRNSAGSSAPGTIADTPLSNGPSWREELELHHRRHGSTETQREREEFAIELAERRRKVQEKLRSVAENESRSSSPNPGRSTPEFSRAGNAFAMLKQKSSKQASTKPDQKKLFGYVGGNSSTPALSDGSWREEERPSFSFGQHPNSSSPHIGSERSIRSRMPSISRDNSYEESRDRGDSPFRDRAGSDASGRSKSRTRLRDDLQTVNEGPIEKGSEPPLPVSRPTSSRPSAEISDPMSFERTSSVASGRHRSSSRSGTPSYQYERPFQFSSNTSSIIGASPRAPPAAPGYSANATPPLNEMPTDGSSTSLASSSSGSQNSQRALGSASLTKRPVNKRLISEPTFLSSTASVPLVGLPPGSALPSPVSAPPVPPMNPRRRRGTATQTILGAFKIDKTDSSRVSSPAPSAEDEHSVFPDDEKRPRSRNRLRKTSSEGGNLNARARQESMADIPPAVPQYPPPAIPAEGGMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q0J0</accession>
    <name>W6Q0J0_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PROQFM164_S01g003583</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q0J0"/>
    <dbReference type="STRING" id="1365484.W6Q0J0"/>
    <dbReference type="OMA" id="WGGENTS"/>
    <dbReference type="OrthoDB" id="5979581at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050684">
        <property type="term" value="P:regulation of mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051334">
        <property type="entry name" value="SRPK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634:SF9">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM29770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="231" mass="26864" checksum="8E82CE53E4DB807F" modified="2014-04-16" version="1">MNWRVSGMRVWSNTRLIQRYGISSPFPISTYQLISPFDRKTAWSRRCSSQWTSNPRVFPVFDLGLLDSSVKIEEELATGYEPNETYTYPVEDEETLNDRYRILHKIGYGPTATVWYAVDLTEPRMVVLKIYVVDHMLKSYGRLNPPKTYQQSECPLHEVSDRFSIEGPRGPHICVVHEAPSLDPGQMHAGDKLDLKSTKSTIKQLLVMLDFLHTDCYLTARIFTRHRFWDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q0J9</accession>
    <name>W6Q0J9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type DNA-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PROQFM164_S01g003303</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q0J9"/>
    <dbReference type="STRING" id="1365484.W6Q0J9"/>
    <dbReference type="OMA" id="PIKFAFC"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053181">
        <property type="entry name" value="EcdB-like_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47785:SF6">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47785">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="56"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="534"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="534"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="565"/>
            <end position="577"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM29491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="717" mass="80900" checksum="9A52C647F80B9154" modified="2014-04-16" version="1">MSKRSLEESRAGAHMSPDPDNNGLLPIQDLLSPGEEEHGQSSGPSKKPRNFIATVACETCRLKKTRCDESRPRCGLCKSLGLECVYNERKSSKRDQSLTMIMSTLHRLETKLENIPTSILGDLQSLRSQIRPVREPQTQLSPAFGGDNQPLSMLSSIGDNFTPAAGDGDDFEFEENQPKSDSAGRISISFSQHGVIVWPGARQILPKQLLAAYEMLGKNYVIELESARPPLPMFTSPYPLQAGDHWLEILPLAMIRGLADAFFSVFNPSTPIMDKGFFFSFTLGTAIESGFGYNLESCLVLNVLALGCLAVLAYQEGNYPLPGTQAHRFEPPEWMNVVYEEQPGLRFFNEARRRIGFLMCDNDIQSCQFYLLSSVYYNQIPRPMDSWTMVSRAATCCLSMLINHNVNFDEWEGDMKSRVYWNCLMNETILVQELHLPPSGLSRLEEQVPIPKFIGFETTGYASNRFNSSSVVDDSYFQYHFLAQVAHRIILTRIRHSLYFYSDSGTFPLPAINTELHHQLEQWRTNLPTAIQFNNAPYSSHPTPATPSIHTSPPASVASPAHLSSPRSRPTDPNQPLSPAIAVADAMLKGRYMIARFHIGRPYLYKALRIPHLLTDEDFVQVRSGLQNAMDWPVTQGIFRKMKSCIPIKFAFCSQFFGQILLFYCIAHSPSARLRETLPDGWERWNEEMLGFLEDCAVHSPAVTQDLELLRYLWPDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q0U1</accession>
    <name>W6Q0U1_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Altered inheritance of mitochondria protein 9, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Found in mitochondrial proteome protein 29</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PROQFM164_S02g000317</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AIM9 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q0U1"/>
    <dbReference type="STRING" id="1365484.W6Q0U1"/>
    <dbReference type="OrthoDB" id="10003767at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051035">
        <property type="entry name" value="Mito_inheritance_9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36091">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36091:SF1">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM30168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="211" mass="23596" checksum="DB7EA54FE9C712AE" modified="2014-04-16" version="1">MHRLFTQSARSLKRSCLSKNWNSVNDFFEYTRGLNVSNEDHELSIRRVKFDMNELARLAADSVGSREYAHIEKFPDGMFNKTLLFTMANGAEVVGKVPNPNAGQPHFTTASEVATMEFVRNILGTPAPCVLAWSSKAGENAVGAEYIIMEKVGRIQLGHAWDKMGIEDRFEIVKAIAGYQTSWLSTSSTKYGSLSYSCDTDHQKECVLILM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q106</accession>
    <name>W6Q106_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S02g000382</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q106"/>
    <dbReference type="OMA" id="YRDINYT"/>
    <dbReference type="OrthoDB" id="4354599at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM30233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="138" mass="16129" checksum="27C17438C35D604E" modified="2014-04-16" version="1">MSLTRPNHLSYEQHFERECEFFQETLLREADSLNRLENRRAGTIQIICDLIVQLEIVRRLAETMARKSPMCPTVLISPPGYFRGEFQSFCRAKILPGLIRSLTCLNESDIIYRDINYSVAAQLEEIHEDFTFVLDSRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q111</accession>
    <name>W6Q111_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="7">O-methyltransferase, caffeic acid-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PROQFM164_S01g001705</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q111"/>
    <dbReference type="STRING" id="1365484.W6Q111"/>
    <dbReference type="OMA" id="FQIMQNI"/>
    <dbReference type="OrthoDB" id="1535081at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="COMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012967">
        <property type="entry name" value="COMT_dimerisation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712:SF2">
        <property type="entry name" value="O-METHYLTRANSFERASE CICE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08100">
        <property type="entry name" value="Dimerisation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005739">
        <property type="entry name" value="O-mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="O-methyltransferase dimerisation" evidence="6">
        <location>
            <begin position="75"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="O-methyltransferase C-terminal" evidence="5">
        <location>
            <begin position="182"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR005739-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM27894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="401" mass="45037" checksum="36A271F12FBD0FA1" modified="2014-04-16" version="1">MTIEVMSHEPSPIKLASLASTINEAILQYSHAESESERISALKSIDVTSQKLAQCAVEPRRSLMAFHFQPHKVLCVRLAIEMRLFDNLPTSAPFTVEHLAKQAGTDLEFTSRIARALGALNIFEEVGEDTFKQTALSQEWNDKFMQSYTRHSWDNVFRPMSSYIEFFNTTGFVSPSDRLNTPFAFAKGAKNVDFFSLLQQDPKAATIFNEAMTSFKDPLGDLYNFSSLQVEEDGVVLVDIGGGKGQSIQSIQSSYPNLKGRYVLQDLPAVIAAGDRVCSPEVEVQPYNFFEEVQPIKGAAAYLLKLILHDWQDAECRTILRNLAPAMRGYKSKLLICDIVLTDTRPDTQKVLYDINMFFMAGKERSVKQWHALMEGTGFRIERIIGLDNPVRSIIEVVLDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q1B4</accession>
    <name>W6Q1B4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S01g001820</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q1B4"/>
    <dbReference type="OMA" id="HVVNDNP"/>
    <dbReference type="OrthoDB" id="4368889at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004881204" evidence="2">
        <location>
            <begin position="22"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM28009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="150" mass="15545" checksum="709F5E199AC913E4" modified="2014-04-16" version="1">MARFSLSFISIFLVLAVFALSMPTKRDEQAATQPFSLDGTLKELMHASKLMDGLDNKDSNEKDNDTAESKAQQQQASKEEAKQGEAKVAAKLADKEAAGDKPTATPTKGLSSGNFVTPTATPTHKATSQPNALGSLPLIGGLLGGAGGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q2A5</accession>
    <name>W6Q2A5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CCAAT-binding factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S02g000589</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CBF/MAK21 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q2A5"/>
    <dbReference type="STRING" id="1365484.W6Q2A5"/>
    <dbReference type="OMA" id="EIWCNDE"/>
    <dbReference type="OrthoDB" id="28947at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005612">
        <property type="entry name" value="CCAAT-binding_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040155">
        <property type="entry name" value="CEBPZ/Mak21-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12048">
        <property type="entry name" value="CCAAT-BINDING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12048:SF0">
        <property type="entry name" value="CCAAT_ENHANCER-BINDING PROTEIN ZETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03914">
        <property type="entry name" value="CBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCAAT-binding factor" evidence="3">
        <location>
            <begin position="644"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="556"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="765"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="922"/>
            <end position="1093"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="15"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="65"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="93"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="160"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="186"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="563"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="785"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="930"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="959"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="999"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1035"/>
            <end position="1061"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM30440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="1113" mass="123739" checksum="BB200960AEE29FE6" modified="2014-04-16" version="1">MATGKGKRSSSANESAPATSISAPAAEPLPFMPDESAFAGLRQKIEQRLKNQSQTTGKGKKDNNKPSASATNAFANKGKQFPAKPGRPQDSAQGKKRDRNGEVIAREQNKDGMNKQEKPKAGKKSNDDETLRQEILAMGGTEEDLDLLAGVESESEVEGESGKVDDDLRKQLSSMLEASGHVVPEDLADDEVEEEIESEEDIEDSEDNAESSGPESDIEEAPASKTKESESVVPKEYLKLNVLPRSDWYNIPMPSSAGDTKHMNALPRHLMERVHELANKLLQEENEEYAAAQRASASSSHKFYSTIMTSGTLSDKISALTLNVQESPLHNTKALETLISLGKKRSRAQAVEVLRSLKDMFAQGTLLPSDRRLKSFTNQPGLVAAFQGAGGRWNEKDPLPGGLKKSDLIVWAFENIVKDQFFEVIKILEIWCNDEIEFSRTRAVSYVYELLKEKPEQETNLLRLLVNKLGDPGKKIASRASYLLLQLMQSHPMMKPIIIKSVEEVLFRPGQSSHAKYYAVITLNQTILRLKEEKVAAQLLDIYFGLFLVLLKPSHQPTDGKPAHKGKTAPKGKYNKHGKGSKGKGDDDAAKGQAQDDEMREKLISGVLTGVNRAYPFTDSDSERMSKHLDTLFRITHSSNFNTSIQALMLIQQLTVSNQVSGDRFYRTLYESLLDPRVSTSSKQSLYLNLLYKSLKNDLNVRRVKAFVKRLVQVLGMHQPSFICGVFFMIRELEKTFTGLSSLVDQPEENDDDDEEVFRDVLDEDDEQPEAAPVVEAKKQNNVYDPRKRDPEHSNADRSCLWELLPFTSHFHPSVSLNATNLLEHNPMSGKPDLTLHTLTHFLDRFVYRTPKANASSRGASIMQPLGGGEAADRLVEAGKKTQNQVPLNTEAFWKKKANDVAAEDVFFHEYFTRVNKDKEKVRSKKSKDVDDEDNSDAGLSGDEDEIWKALVDSRPELEADEDSDDDLDMSDLESALDSEEDGEGADEDESDGGVIFNDESDVPSDEEMAEFSEPEEAAPAVKTKKAAKKPSKEVEEDSDDFDMDVSDDDAFIDSDEDLPSDMELGGVGLEEPEKPDAAPESNRSKRRKLKQLPTFASADDYAALLEDEDDGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q2M4</accession>
    <name>W6Q2M4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S01g002275</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q2M4"/>
    <dbReference type="STRING" id="1365484.W6Q2M4"/>
    <dbReference type="OMA" id="QRDCQTW"/>
    <dbReference type="OrthoDB" id="2999773at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046670">
        <property type="entry name" value="DUF6540"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20174">
        <property type="entry name" value="DUF6540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM28464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="175" mass="19698" checksum="F98C6A5A689EB49C" modified="2014-04-16" version="1">MNTSISKPAVSPTGPSGTFMVELLIYNGSPFKNHWAYFVRSHEDPDIGVKIHATGNVRSGFEFEIKRSENLQITDDIPSTRVPLQWVDADYFDEKAMLNDGEYKIDNAPVCLFEKSAYEVKAPGKTLNSISDGPKPGRKVIQRDCQTWIVESADQLHRDNILSIEVVTYLHAIKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q2W4</accession>
    <name>W6Q2W4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S02g000465</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q2W4"/>
    <dbReference type="OMA" id="VWRSRED"/>
    <dbReference type="OrthoDB" id="2140489at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36986">
        <property type="entry name" value="UPF0643 PROTEIN PB2B2.08"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36986:SF1">
        <property type="entry name" value="UPF0643 PROTEIN PB2B2.08"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM30316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="257" mass="29314" checksum="D4CC0056F12BD02B" modified="2014-04-16" version="1">MTFSIAKSVLINPVPASKSLPDKGEGQEVLSLTRLLHHSHVTTEFDPLRFEAAASLQLKLQLEGQYPDTETDTRLIASPYNSVPHLLDIAALERQDRLFALALAYLKPIRDDYATADYTESFNWTEVYDLLRVFSQAENHTWKSQSYYVVIFRSILLPDIDSDRLYDLDAHSHQEAIASGGLLKYWFGAKNDKHRNLATCIWRSRNDARLGGLGPWHAQARAAAAVMYEQIRFTTLRLDIADGVQSWKLSYWKEDVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q316</accession>
    <name>W6Q316_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="9">L-lactate/malate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PROQFM164_S02g000510</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the LDH/MDH superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q316"/>
    <dbReference type="STRING" id="1365484.W6Q316"/>
    <dbReference type="OMA" id="THLDSMR"/>
    <dbReference type="OrthoDB" id="6270329at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004459">
        <property type="term" value="F:L-lactate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006089">
        <property type="term" value="P:lactate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00300">
        <property type="entry name" value="LDH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.110.10">
        <property type="entry name" value="Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001557">
        <property type="entry name" value="L-lactate/malate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022383">
        <property type="entry name" value="Lactate/malate_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001236">
        <property type="entry name" value="Lactate/malate_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43128">
        <property type="entry name" value="L-2-HYDROXYCARBOXYLATE DEHYDROGENASE (NAD(P)(+))"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43128:SF16">
        <property type="entry name" value="L-LACTATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02866">
        <property type="entry name" value="Ldh_1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00056">
        <property type="entry name" value="Ldh_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000102">
        <property type="entry name" value="Lac_mal_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00086">
        <property type="entry name" value="LLDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="LDH C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 4" id="KW-0520">NAD</keyword>
    <keyword evidence="1 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="Lactate/malate dehydrogenase N-terminal" evidence="7">
        <location>
            <begin position="11"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="Lactate/malate dehydrogenase C-terminal" evidence="8">
        <location>
            <begin position="152"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="182"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="16"/>
            <end position="21"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM30361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="313" mass="33588" checksum="32E7546654D6F8F5" modified="2014-04-16" version="1">MLSRDSNAITRIAIIGVGQVGAALAYALILNSTAGELLLVDTKPDLRDGQVRDLSDVSYSCNSGTRVRAATHHEAGQCDVVVITAGSKSYRGETTIQHMYQKVAIIQSITNAMKPFRSDTILLIVAHPVDLITSFAQEHSGLPASQVLGSGTFLDSVRLRGMLADKAGVAANAIDLQVLGVHGESEVVAWSTATLCGVPIDKALPSNTFNPKDLANECKHRSQRIIQAKGTVSFGIGSALSRICSSILMDKRDVYPISHFQPEWGCCFSLPAALGRSGIIRTVEMATNSNEKADIRDSVEILSDTLKRVRENQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q3L4</accession>
    <name>W6Q3L4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pseudouridine synthase, RluC/RluD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S02g001348</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q3L4"/>
    <dbReference type="STRING" id="1365484.W6Q3L4"/>
    <dbReference type="OMA" id="EPPVMAC"/>
    <dbReference type="OrthoDB" id="424794at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02557">
        <property type="entry name" value="PseudoU_synth_ScRIB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.10">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006224">
        <property type="entry name" value="PsdUridine_synth_RluA-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006225">
        <property type="entry name" value="PsdUridine_synth_RluC/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050188">
        <property type="entry name" value="RluA_PseudoU_synthase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00005">
        <property type="entry name" value="rluA_subfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21600">
        <property type="entry name" value="MITOCHONDRIAL RNA PSEUDOURIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21600:SF40">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE RPUSD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01129">
        <property type="entry name" value="PSI_RLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Pseudouridine synthase RsuA/RluA-like" evidence="3">
        <location>
            <begin position="130"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR606225-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM31198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="527" mass="58041" checksum="5EB5A432BA73400E" modified="2014-04-16" version="1">MALTTVDQVPPSKPVEKTPDVLVTPCDPWPAPYYLDGGFRRVTPYHYTYNTNCKERWRGRQLVEIFTSEFRDRKPEYYRKALEDGLVQVNGVTARPETTLKNGQVISHTLHRHEPPVTSLPVGIIHEDDDLLVIDKPAGVPVHAAGRYHFNTVIEILRSERSSEWLPRPCNRLDRLTSGIMFIGKHAKGAEKMATALKARSVQKEYVARVKGKFPDGVVVCDQPIMQVSPKLGLNRVRATGKEATTKFRRLAYYPPEAAKETESSSDEQRPATPVPAFANESEGYSIVHCFPLTGRTHQIRVHLQFLGHPITNDPIYSNRRVFGPELGKAEVTAERDEEIVARLSLMGKTEIPDTVSYRTHLTAAPNVPPGTDPVLVNEIMHREQVAAAEDYEKRKGERLSGNLCEVCGTELYSDPGPHELGIFLHAVAYADRDGDWAYRSPMPRWGLPPAGMDGPRECPDWVPAAEGEEVVIGNGTIPAGLGDDDFAADSKTGSVLLEGVGLVNLSEAAGMNVSLGEATEAAAATN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q5A3</accession>
    <name>W6Q5A3_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">proline--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Prolyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PROQFM164_S02g001306</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>tRNA(Pro) + L-proline + ATP = L-prolyl-tRNA(Pro) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:14305"/>
            <dbReference type="Rhea" id="RHEA-COMP:9700"/>
            <dbReference type="Rhea" id="RHEA-COMP:9702"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78532"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.15"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.15" evidence="2"/>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q5A3"/>
    <dbReference type="STRING" id="1365484.W6Q5A3"/>
    <dbReference type="OMA" id="EVYWVTH"/>
    <dbReference type="OrthoDB" id="1350766at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017101">
        <property type="term" value="C:aminoacyl-tRNA synthetase multienzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004827">
        <property type="term" value="F:proline-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006433">
        <property type="term" value="P:prolyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00778">
        <property type="entry name" value="ProRS_core_arch_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.110.30:FF:000001">
        <property type="entry name" value="Bifunctional glutamate/proline--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000007">
        <property type="entry name" value="Bifunctional glutamate/proline--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.800:FF:000005">
        <property type="entry name" value="bifunctional glutamate/proline--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.30">
        <property type="entry name" value="C-terminal domain of ProRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01571">
        <property type="entry name" value="Pro_tRNA_synth_type3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002316">
        <property type="entry name" value="Pro-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004499">
        <property type="entry name" value="Pro-tRNA-ligase_IIa_arc-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016061">
        <property type="entry name" value="Pro-tRNA_ligase_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017449">
        <property type="entry name" value="Pro-tRNA_synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033721">
        <property type="entry name" value="ProRS_core_arch_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00408">
        <property type="entry name" value="proS_fam_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43382:SF2">
        <property type="entry name" value="BIFUNCTIONAL GLUTAMATE_PROLINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43382">
        <property type="entry name" value="PROLYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09180">
        <property type="entry name" value="ProRS-C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01046">
        <property type="entry name" value="TRNASYNTHPRO"/>
    </dbReference>
    <dbReference type="SMART" id="SM00946">
        <property type="entry name" value="ProRS-C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64586">
        <property type="entry name" value="C-terminal domain of ProRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="11">
        <location>
            <begin position="124"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="22"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="38"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="48"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDM31156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="597" mass="66278" checksum="73128D0A3DA75E41" modified="2014-04-16" version="1">MASQNPSEDRTPEGAAPQTLPDRTETPADDKAGESKNAAKKAAKLAKLKADKADKKASNKGEKGIGKQEAKKASKKKVDGAALIGIDVLKEEDFSGWYQQVLTKGDLLDYYDVSGCFILKPALFFIWEEIQEYFNKAIKGMGVKNCSFPLFVSEDVLQREKDHIEGFAAEVAWVTHAGSTPLEKKIAIRPTSETVMYPYYAKWIRSHRDLPLRLNQWNSVVRWEFKHPQPLLRSREFLWQEGHTAHLTEGAAREEVLSILDYYAKIYKELLAVPVVKGQKTEKEKFAGGNYTTTVEGYIPATGRGIQGGTSHGLGQNFSKMFGITVEDPTSTVDEKKPPLHVWQNSWGLSTRSLGVMVMIHSDNKGLVLPPRVAEVQVIIVPVGLTAKTTEEEREKLNVEVDGLVAVLVAAGIRADSDKSSYSPGWKFNQYELRGVPLRIEFGPGESAGHFVTTARRDIPGKDGKGSIPIPELATGVSALLETIQTDLYNRADEQFKAHRIQITKWDDFVPALNNKNLCVIPHCLTEECEDQIKEMSARKAEEDSGEAEDAKAPSMGAKSLCIPFEQPEGIEQGVTPCCNPKCQRFAEKWCMFGRSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q5R3</accession>
    <name>W6Q5R3_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phospholipase/carboxylesterase/thioesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S01g003391</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q5R3"/>
    <dbReference type="STRING" id="1365484.W6Q5R3"/>
    <dbReference type="OMA" id="VMQFFAR"/>
    <dbReference type="OrthoDB" id="437457at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008474">
        <property type="term" value="F:palmitoyl-(protein) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050565">
        <property type="entry name" value="LYPA1-2/EST-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003140">
        <property type="entry name" value="PLipase/COase/thioEstase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655">
        <property type="entry name" value="LYSOPHOSPHOLIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655:SF67">
        <property type="entry name" value="PHOSPHOLIPASE_CARBOXYLESTERASE SUPERFAMILY (AFU_ORTHOLOGUE AFUA_5G09340)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02230">
        <property type="entry name" value="Abhydrolase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phospholipase/carboxylesterase/thioesterase" evidence="2">
        <location>
            <begin position="31"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM29579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="266" mass="28141" checksum="B20285A94CE020F2" modified="2014-04-16" version="1">MPTKTPAPCDFPSELTVTITPAPPFPARSQSASPAPNILLLLHGLGDTAASFTKFAEAIRLPETTIVTVQGTAPLPFDLGGFHWGDDVSFDSATGALDMDAGMTRSTRILVEDVVRDTLVQKCGYALREIMALGFGQGGMAALAMARELGLKGKEAGNGNGNADSGEVGTLSGVISIGAPYPLSGSRVGNTNRTPVLLVAGRDSVAVSDEAVRRTKQVFEFVEVSRYARRGDGMPSNREEMLPVMQFFARRLRSRQGVPEGSVEIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q5T7</accession>
    <name>W6Q5T7_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g003416</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q5T7"/>
    <dbReference type="OMA" id="YTENDRA"/>
    <dbReference type="OrthoDB" id="4369499at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM29604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="305" mass="34367" checksum="4855E081246C0694" modified="2014-04-16" version="1">MASHAFCCDNVRPRDFEDGDYRLGIFIYWAKSGKRPQTKDDNLGLNVPFCVQVTQRYPRLTRLFVPTSWGEFAENDREFLGAPWVLLMNEPTNVAGEPNTKPSAETDHTQSPFSTDAKYGMENIASLANMPAGQFVLDLIDRARNTMPLNKVSLATEADILKTHLLHDLRKLTESVDQNISIWMLLTTSYPIAKLLMSFGPSNVYTENDRAKILKATAIAVNAVQVLAFNQRGPQDYNPPDGIEVFEEIRRQHPNDEDLTSLVNCALKEVRGYSETEEKARLAEKKVYLSVSDDGYDHCDLSISD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q688</accession>
    <name>W6Q688_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S02g001971</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q688"/>
    <dbReference type="OMA" id="AGIWSNI"/>
    <dbReference type="OrthoDB" id="10513245at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM31820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="85" mass="10153" checksum="59E4E49E724F13D6" modified="2014-04-16" version="1">MLTQLRLIRTTLAHSQRTKMRQARMVIRRVQLLTSQCAANGQASTPHALWRLERRIQSLFRNILRLQAEQEAAREFEVEIWRNVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q749</accession>
    <name>W6Q749_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ran GTPase-activating protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rna1</name>
        <name evidence="5" type="ORF">PROQFM164_S02g001937</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q749"/>
    <dbReference type="STRING" id="1365484.W6Q749"/>
    <dbReference type="OMA" id="NGSMEAW"/>
    <dbReference type="OrthoDB" id="184583at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006913">
        <property type="term" value="P:nucleocytoplasmic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00116">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027038">
        <property type="entry name" value="RanGap"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113">
        <property type="entry name" value="RAN GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113:SF12">
        <property type="entry name" value="RAN GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="340"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="347"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="382"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDM31786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="418" mass="45968" checksum="445820862BCE0BA5" modified="2014-04-16" version="1">MAPHKVFSLEGKVLKLDTAEDMNAHIQPLIDNTDYTEIRLGGNTLGIDASKRLAEVLQNQKCLEAAYFDDIFTGRLLTEIPTALNSLLNAILKISTVHTVNLNDNAFGLRTQAPLIEFLSRHVPLRHLILNNNGLGPAAGSQVADALSKLAERKEEARNCGEEVALLESVVCGRNRLENGSMEAWARAYKAHAAGLKSVKMTQNGIRSEGISHLLSEGLYHAHSLEVLDLQDNTFTHVGSTALSNALSGWPSLRELGVGDCLLSARGGVKVAQALAQNKNPKLQTLRLQYNEMKAEAVKSFTHAAKTALPSLRRVELNGNIFSEEDPHIVDLRELLEARQGEHGTDDDPEDTWGVDDLDELEEEDSEEEEEEEEEEDEEEAKADKDLKDADLAEEEKVAEREDKDVDDLADVLGKTGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q7A6</accession>
    <name>W6Q7A6_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">chitinase</fullName>
            <ecNumber evidence="2">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PROQFM164_S02g001997</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the glycosyl hydrolase 18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="2"/>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q7A6"/>
    <dbReference type="STRING" id="1365484.W6Q7A6"/>
    <dbReference type="OMA" id="MAYYAKW"/>
    <dbReference type="OrthoDB" id="73875at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11618">
        <property type="entry name" value="ChtBD1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000159">
        <property type="entry name" value="Class V chitinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.10">
        <property type="entry name" value="Endochitinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001002">
        <property type="entry name" value="Chitin-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018371">
        <property type="entry name" value="Chitin-binding_1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036861">
        <property type="entry name" value="Endochitinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF337">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00187">
        <property type="entry name" value="Chitin_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57016">
        <property type="entry name" value="Plant lectins/antimicrobial peptides"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00026">
        <property type="entry name" value="CHIT_BIND_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50941">
        <property type="entry name" value="CHIT_BIND_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="3 10" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8 11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004881338" description="chitinase" evidence="13">
        <location>
            <begin position="18"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="15">
        <location>
            <begin position="18"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-1" evidence="14">
        <location>
            <begin position="302"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="313"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="318"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CDM31846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="437" mass="47370" checksum="04E35201646080A0" modified="2014-04-16" version="1">MLKRLALGLLAAQSVAATRFAMYIDEYHVTALSGQNQTEGIDYAIMSFAASKLFNSDSPAAYKPFESPETMRKRFSSGTKLMVAIGGWGDTAGFSEGAKDAASRTRYAKNVASMLDANGFDGVDIDWEYPGGNGQDYKDVPNSKKVDEIETYPLFLEAVRKAIGNKTLSIAVPGRKQDFIAFTKEQGPKIFKSVDMVNVMSYDLINRRDNVTGHASGVQGSLDTINEYIAIGADPAKLNLGFAYYAKWFTTDPNSDCDENPLGCHLAKLENDDGTDNGKSGAMTFEASTAAAAPKDLKQSTDGLCGFGAKAKCPSGQCCSSSGYCGTGDDFCQAGCLSDYGTCKGISITDSWRKAQKDGKTDEKGGGQYYFDSDNNLFWTWDTPELIARKFKEIVAEKKLGGVMAWSLGEDTYKFEHLEAMQKGLKSHSPKVAEPPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q7P9</accession>
    <name>W6Q7P9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosomal protein S10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PROQFM164_S02g002187</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS10 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q7P9"/>
    <dbReference type="STRING" id="1365484.W6Q7P9"/>
    <dbReference type="OMA" id="IHKRVIH"/>
    <dbReference type="OrthoDB" id="10248551at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.600:FF:000002">
        <property type="entry name" value="40S ribosomal protein S20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.600">
        <property type="entry name" value="Ribosomal protein S10 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00508">
        <property type="entry name" value="Ribosomal_uS10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001848">
        <property type="entry name" value="Ribosomal_uS10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018268">
        <property type="entry name" value="Ribosomal_uS10_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027486">
        <property type="entry name" value="Ribosomal_uS10_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036838">
        <property type="entry name" value="Ribosomal_uS10_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005729">
        <property type="entry name" value="Ribosomal_uS10_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01046">
        <property type="entry name" value="uS10_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11700">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S10 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00338">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00971">
        <property type="entry name" value="RIBOSOMALS10"/>
    </dbReference>
    <dbReference type="SMART" id="SM01403">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54999">
        <property type="entry name" value="Ribosomal protein S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00361">
        <property type="entry name" value="RIBOSOMAL_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS10" evidence="4">
        <location>
            <begin position="20"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDM32036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="116" mass="13077" checksum="03041A44023405E5" modified="2014-04-16" version="1">MSFQKPEKDFGEGPKVHKIRITLTSRKVASLEKVCQELIDRARSKSLQVKGPVRLPTKTLQISTRKTPNGEGSKTWDKFEMRIHKRLIDLLAPTETVKQIIINIEAGVEVEVTIAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q7W2</accession>
    <name>W6Q7W2_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S02g002944</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q7W2"/>
    <dbReference type="OMA" id="EYDYTIH"/>
    <dbReference type="OrthoDB" id="5429442at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="478"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="479"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM32793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="571" mass="64718" checksum="F98A742D077B5DBF" modified="2014-04-16" version="1">MASEKDKRLQSSLKTATGAFDQAVAVSQDALNDGLYYLFDKYEDLQKMKVNKKKFGRIDAMMDHAEVSLPVKSSSYRTLVFYCIFQTGKLVLTDDDGNDKKPIDLADWRFAFEVDYTTLDVPSDTTEHQEAKKQMNQPGDYSIKRLFLDFKTHKIRNFNKDLSDFKGHNWDSEDLQSFLSLITFWGDPEKGVMKDKQKSTLGYFLTTAKPETVNPPAPTFPPTSVKHQHYKYIAPGKQTPDEGPKDGKNNMLLYLEMTQNRSFPSEDILEYSGNFVTPGMKGTTCISRDIFWDSYLLRNPSLSGPYGPQPPLLREFNRHVYAWLGEFHVWAKNYSTDLSWSYGFGHTRWEPSRSPDYFAWKKVSANKWEWKNKDKKSGHDEGIWPLRLDAKASSDTLNELRFDPGSNKIHLEGCSKVWAEMKRSDFQNIEEKGGVAINWALDITIDSVSEGGLKLNMNLPANPKDIFHTTALTKPFATEAEETQDEAEPAENEPAESTPKTGKTGKISVHDMTEAANDAAAKLDFKSVTSNLQTALENSARFVLPGGRQFFYNNAVFGNNGDLLVEAKYKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q805</accession>
    <name>W6Q805_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S02g002989</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q805"/>
    <dbReference type="STRING" id="1365484.W6Q805"/>
    <dbReference type="OMA" id="HEYKMYI"/>
    <dbReference type="OrthoDB" id="4691160at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004879636" evidence="1">
        <location>
            <begin position="20"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM32838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="115" mass="13179" checksum="6E08A0387618820E" modified="2014-04-16" version="1">MHYITALSLIASLLGMVAATGNSVRRYVQLRAWGQPGCRASNLGEEGIYSDYIGLYMPFSNYNIIRSVSVESVESGYTLYIYRNLQYHSERIKVPFIKCVSGEHEYKMYILVYDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q8I7</accession>
    <name>W6Q8I7_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S02g002851</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q8I7"/>
    <dbReference type="OrthoDB" id="4347333at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM32700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="53" mass="6095" checksum="A701D78AB2750F27" modified="2014-04-16" version="1">MLRGTPSSTVKYTVASGLFRQIEDKTKVAAEQRAPSHRVFRLRPHRLRTVEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q957</accession>
    <name>W6Q957_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Aromatic-ring hydroxylase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PROQFM164_S02g003086</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q957"/>
    <dbReference type="STRING" id="1365484.W6Q957"/>
    <dbReference type="OMA" id="VPGLVFW"/>
    <dbReference type="OrthoDB" id="2431938at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050562">
        <property type="entry name" value="FAD_mOase_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47356:SF2">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47356">
        <property type="entry name" value="FAD-DEPENDENT MONOOXYGENASE ASQG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="FAD-binding" evidence="9">
        <location>
            <begin position="11"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDM32935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="480" mass="53372" checksum="9921FC0EBC6779FE" modified="2014-04-16" version="1">MASFDQDKNQFKVLIAGGSLVGLGLALAFERAGIEYELFERGDFATQLGASIGIHPHTIRILEQLGVWEDIERQVIPLQVRKHYDGNGHCFEDSLVLVDINEILQRPIVFMERCKALEVLYNHVQDKSKLHARTAVVGYEETPQTVIVTTEDGTQHHGHILIGADGIHSKVRKLMADKISVTDQALANEINEAFTSEYDCIFAVSRNDAGKQFLPDAMVHNVYYDKYSAIAAAGVPGLVFWFLFVKDSKCTRTPNCPRFTDEDAEATILKYGSSLVGPEYTVKDLWDARVKGTMVPLEEGVIKQWSHNRVVLMGDSVHKATINPGLGGNLAYEGIARLTNGLVPLLKDNPMPSLQQLTEVFNQYIAGQEPRAKTVVDLSGQITRYEAQDTWVLKFAARHIVPWVSDRIKAKLYASFSRGGPYLEYLPLPAMDAEPAKSAKKHSRGIFPKQITIVMLIGGTAAIFWDVCGRFGPDRREGTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q9G9</accession>
    <name>W6Q9G9_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA sliding clamp PCNA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">pcn1</name>
        <name evidence="11" type="ORF">PROQFM164_S01g000226</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. Involved in DNA repair.</text>
    </comment>
    <comment type="function">
        <text evidence="7">This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processivity during elongation of the leading strand.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the PCNA family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q9G9"/>
    <dbReference type="STRING" id="1365484.W6Q9G9"/>
    <dbReference type="OMA" id="EMKLINM"/>
    <dbReference type="OrthoDB" id="534348at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043626">
        <property type="term" value="C:PCNA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030337">
        <property type="term" value="F:DNA polymerase processivity factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070987">
        <property type="term" value="P:error-free translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006273">
        <property type="term" value="P:lagging strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006272">
        <property type="term" value="P:leading strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006275">
        <property type="term" value="P:regulation of DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00577">
        <property type="entry name" value="PCNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.150.10:FF:000006">
        <property type="entry name" value="Proliferating cell nuclear antigen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.150.10:FF:000015">
        <property type="entry name" value="Proliferating cell nuclear antigen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.70.10.10:FF:000001">
        <property type="entry name" value="Proliferating cell nuclear antigen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.150.10">
        <property type="entry name" value="DNA Polymerase III, subunit A, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046938">
        <property type="entry name" value="DNA_clamp_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000730">
        <property type="entry name" value="Pr_cel_nuc_antig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022649">
        <property type="entry name" value="Pr_cel_nuc_antig_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022659">
        <property type="entry name" value="Pr_cel_nuc_antig_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022648">
        <property type="entry name" value="Pr_cel_nuc_antig_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00590">
        <property type="entry name" value="pcna"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11352">
        <property type="entry name" value="PROLIFERATING CELL NUCLEAR ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11352:SF0">
        <property type="entry name" value="PROLIFERATING CELL NUCLEAR ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02747">
        <property type="entry name" value="PCNA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00705">
        <property type="entry name" value="PCNA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00339">
        <property type="entry name" value="PCNACYCLIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55979">
        <property type="entry name" value="DNA clamp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00293">
        <property type="entry name" value="PCNA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proliferating cell nuclear antigen PCNA N-terminal" evidence="9">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="Proliferating cell nuclear antigen PCNA C-terminal" evidence="10">
        <location>
            <begin position="89"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00054163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDM26417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="219" mass="24224" checksum="2C34DF9B5E7B4DE5" modified="2014-04-16" version="1">MDNSHVALVSMLLRAEGFSPYRCDRNIALGINLLSLTKVLRAAQNEDILTLKAEDSPDSVNLMFESPDTDRLTEYDIKLMDIDQEHLAIPETEYSASVEMPSAEFQRICRDLNAMSESVVIEASKEGVKFSCQGDIGNGSVTIRQHTNVDKPEQNVVINLSEPVALTFSLKYLVNFCKASNLSSSVVLHLSDEVPLLVEYGLGSGHLRFYLAPKIGDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q9T5</accession>
    <name>W6Q9T5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S03</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S03g000137</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q9T5"/>
    <dbReference type="STRING" id="1365484.W6Q9T5"/>
    <dbReference type="OrthoDB" id="3508621at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM33413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="159" mass="18137" checksum="C1C974D4FF5C55B0" modified="2014-04-16" version="1">MTACTNVYLEGSHIRETFAIIEVIAARRGWSARPEVLWQEAAQMVTWIVTDANFRKCLLDRRLLISQDEDDIYLTLAQYPPEYPAYLQGDLCPSRGTALPFLTMQDYGPWVIESKSNMRHFAMVIMSYCLQLTDEMEKVRARKASSSQGEASSSKGKCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q9V7</accession>
    <name>W6Q9V7_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S02g002917</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the lcsJ thioesterase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q9V7"/>
    <dbReference type="OMA" id="ECDWNGH"/>
    <dbReference type="OrthoDB" id="265761at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051490">
        <property type="entry name" value="THEM6_lcsJ_thioesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12475">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12475:SF4">
        <property type="entry name" value="PROTEIN THEM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13279">
        <property type="entry name" value="4HBT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM32766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="337" mass="38167" checksum="488FE531DF1206DD" modified="2014-04-16" version="1">MTFAKMIEWLWSSIQSFGLWKFLLAIFLVVNLKTLPLVFHYRIFRPIIQNFLTKKRSHHVSIRCKDKNLPLVFLPCVTTTYTPLLEADYNLHKSNSTYFTDLDASRSHLLSYLCCRGVSLVDQELVAGGRRGIMAAIIGSVTTSFKMEIRIFQQYEVWSRILTWDQKWLYIVTHFVQKGSVKQIDLVTHTLSTGSISGGCARAESENSRDKPARPVIFATSVSKYVFKKGRLTVAPERLLRASGLLGESRKMGYLPAQHQGLRPRSVEATMNNINENGAIEIGQVIEKERLKGMKYANAWAELDPLHEELLGESETSDCVPTIGHFGDIAGYGISYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>W6QBK8</accession>
    <name>W6QBK8_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="4">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">CDC14</name>
        <name evidence="17" type="ORF">PROQFM164_S03g000559</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein-tyrosine phosphatase family. Non-receptor class CDC14 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="4"/>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QBK8"/>
    <dbReference type="STRING" id="1365484.W6QBK8"/>
    <dbReference type="OMA" id="KFERVDM"/>
    <dbReference type="OrthoDB" id="5632at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033554">
        <property type="term" value="P:cellular response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032954">
        <property type="term" value="P:regulation of cytokinetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007096">
        <property type="term" value="P:regulation of exit from mitosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14499">
        <property type="entry name" value="CDC14_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17657">
        <property type="entry name" value="CDC14_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000038">
        <property type="entry name" value="Tyrosine-protein phosphatase CDC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000073">
        <property type="entry name" value="Tyrosine-protein phosphatase CDC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044506">
        <property type="entry name" value="CDC14_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029260">
        <property type="entry name" value="DSPn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050561">
        <property type="entry name" value="PTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23339">
        <property type="entry name" value="TYROSINE SPECIFIC PROTEIN PHOSPHATASE AND DUAL SPECIFICITY PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14671">
        <property type="entry name" value="DSPn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0469">Meiosis</keyword>
    <keyword evidence="8" id="KW-0498">Mitosis</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="15">
        <location>
            <begin position="235"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="16">
        <location>
            <begin position="305"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="33"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="395"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="437"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="539"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="409"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="452"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="500"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="510"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="572"/>
            <end position="583"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CDM33835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="606" mass="67961" checksum="F8B79A2C2D32AF7A" modified="2014-04-16" version="1">MTTDFNHGGQMIEYIQDRLYLASYDSAPSSRTPFPFHQGAPKSPSKRARAQPATPSKRRSPVYFTIDDTLLYNAFHADFGPLHIGHLYRFAVLFHEILGDPANSDRPVVFYSKTDSRSRANAACLVACYMVMIQSWPPHLALAPIAQADPPYMPFRDAGYSQADFILNIQDVVYGVWKAKEQSLCGLRDFNLEEYEKFERVDMGDFNWVTPDFLAFASPQQEPVAPIPVSTPEYNALPTTISEISSSKLSMPFKNVLAHFHQRNVGLVVRLNSELYCPSYFTAMGIAHIDMIFEDGTCPPLQLVRRFIKMAHEMITTKKKGIAVHCKAGLGRTGCLIGAYLIYKYGFTANEVIAFMRFMRPGMVVGPQQHWLHLNQGAFREWWFEDSMREKLAQSIPVTPRVSTKKRTSNGVVSTPPNNSHSKRAALGEIDHNEAATYPDQDLPAPTPGQPRKSHRKDSRHHPYSRTVSGSLAVETEQRSHRSHRKSNESSESEEEIQLRRLAQRSSRSPVASPTSRSISYSATVTASYTLAEDNHKDQENWADHSVPKTPVTRKSGAAPISVSKIRSSPRRATENTRSESRGVRKPSGRIGSNTISPARAIKTIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W6QC98</accession>
    <name>W6QC98_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Armadillo-type fold</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PROQFM164_S03g000440</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the synembryn family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QC98"/>
    <dbReference type="OMA" id="NADPIFT"/>
    <dbReference type="OrthoDB" id="5585685at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001965">
        <property type="term" value="F:G-protein alpha-subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019318">
        <property type="entry name" value="Gua_nucleotide_exch_fac_Ric8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12425">
        <property type="entry name" value="SYNEMBRYN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12425:SF5">
        <property type="entry name" value="SYNEMBRYN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10165">
        <property type="entry name" value="Ric8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="387"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDM33716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="466" mass="51962" checksum="12047CE811EF7DC5" modified="2014-04-16" version="1">MSSLQMQGTAKLQQVTQLLQSLEKDLQENNLSTADRVQTLLQLRQHGTNPTNAEPIYSQNGINTLVRYGVEGETPEVRRAALRCVANALLLDPKMRQAFVDTGYGGKLAEKLKTEDSEDEMVTSRILFYATYNTTLDFKDLIKSHALGENINYQLSRHAKQFPKSGRKPLSQMDELALTDTLKLIYNISKIFPDLAAEFSPSIPHILKIICRIDIPAKPLDGLVGGLLNTLSILDLEEKKGKAFESSPLFPAFDNNCNMDKLISILDQATSIYSPKELEENAVPLLYSLIAIHEVAPNEPRKHMQSLLLPEDTDRSLPIGQSETLSSRLLKLSTGHFTNLKVTISELMFVLSDKDSEKLTKNIGYGFAAGFLAARGIEMPQSAREAYSATEDPETARNPITGQRWAAERQDTGPPMTMEEKEREAERLFVLFERAKANGLLNVENPVTQALHEGRFEELPDDADSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W6QCE7</accession>
    <name>W6QCE7_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S03</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S03g001072</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QCE7"/>
    <dbReference type="OrthoDB" id="4339989at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM34348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="61" mass="6695" checksum="DCD5259E38544F0F" modified="2014-04-16" version="1">MPDDFSKISWSTATTFPIQTALIYIFIDPTQTTFLTKSHVTIPTKGVVSPAPSMSVTSNFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>W6QCH4</accession>
    <name>W6QCH4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type DNA-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PROQFM164_S03g000475</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QCH4"/>
    <dbReference type="STRING" id="1365484.W6QCH4"/>
    <dbReference type="OMA" id="YDGALIQ"/>
    <dbReference type="OrthoDB" id="3266505at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF17">
        <property type="entry name" value="SCFA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="17"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="45"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="654"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="49"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="667"/>
            <end position="685"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM33751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="750" mass="84650" checksum="C049757E1753CE5A" modified="2014-04-16" version="1">MEQKTSVVPKPPRTSRECDRCLSQKLKCDGAHPCVLCTRAGDKCETSQRRVRRTRGQNPRGRRRHMNSGVHRAIAPAPPKDSNSIHGAGVAEIASAPESSTSCPERLSKELPPGANASYPERSPEELQSGANGFAIDFARQVFNEEEAGRTLTGASIPIPDDTEAPTLDNSLWHHPTEVELPPEAVILALVDVYFDRMQWFILLLHEPSFRQTARRITSQTVWRRQDLSTTMLVLAVAMIGLHSVLPDDRWPGHELLREYSVDGEKLMHYLNNEIQRNLLDISIDCRIEAVQVCLLVSSYYIYHRSPSLAWTVSGMGVRSANALHLYTKSVQYESPVVDEIRSRCWNHAISSDTFASVVYGRPCSIDTELVALHSPREMDDLAIDPLLLENEWIFGDGMPKTTAGFFAMKYEIYNIIRDILSRFRRLQLRKETIEEDLLAIVEAAQDSEEQLVSWRKRVPRLFDFEFWSCDNRLEQFQRQIEMLPQRTKYQAETIILQAAILQLTYDGALIQAHRPLLEQKITSSCSRLVVDAIHESFRVATAAALRISHIPVLRFKHHFAESFASLQQFTAGVILCILPTCQPFTSAAHEAKAGIIRIIHASSAFGPRNRIAKQTVQLLTELLKVTVDREMSSALRRGVETIIPRRISERGSILNAQPRIDHTRSDSLSSRDTSLDQSSTSTSHALPQAIHDHSRVNDRIAQAPVKPPEYPSANIFEQLDDTFAAFGERMFNLISDDQSSAWNWGRTVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W6QCM9</accession>
    <name>W6QCM9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S03</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S03g000535</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QCM9"/>
    <dbReference type="OrthoDB" id="10492517at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM33811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="79" mass="8726" checksum="53E0983F820CDF24" modified="2014-04-16" version="1">MAALTITKLGLIELGFSTRLAVDVVKIYLRFQLSTLANSYLFSSGVSARQVKWTEGGKKIYGVISATTWRVNCTASYLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W6QD48</accession>
    <name>W6QD48_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidoglycan-binding lysin domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S03g001114</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QD48"/>
    <dbReference type="STRING" id="1365484.W6QD48"/>
    <dbReference type="OMA" id="LTRICTT"/>
    <dbReference type="OrthoDB" id="5985073at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LysM" evidence="1">
        <location>
            <begin position="199"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM34390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="276" mass="29248" checksum="21798692F5EF4A5F" modified="2014-04-16" version="1">MILPSTLTSECTAALTVDVTVCDPLVRDLRLDIFYPPASLTRICTTGCSSALETWRSSVQSVCGNQTVTVDLEVETAAVYIPGALQYYFQHACLKDDGGRFCRPVAALAAVFSDPGISPFNYISNVTGQLLPDDCDTCLAERLRLREGSPYDDGPIAVRMSLYKSMTASCGIAGRPVVPTTIGYFTAAPAPTAEVCEGSTYTIQASDDCYTISRSQGVGTNWLLADNNLEVFCTNFPAAGTSICITNQCTTVTVPVNATCEAVAAAANITEAQLIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W6QD58</accession>
    <name>W6QD58_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcription initiation factor Rrn11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g001348</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QD58"/>
    <dbReference type="STRING" id="1365484.W6QD58"/>
    <dbReference type="OMA" id="TPNESHQ"/>
    <dbReference type="OrthoDB" id="2159786at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070860">
        <property type="term" value="C:RNA polymerase I core factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001164">
        <property type="term" value="F:RNA polymerase I core promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001181">
        <property type="term" value="F:RNA polymerase I general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042790">
        <property type="term" value="P:nucleolar large rRNA transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053029">
        <property type="entry name" value="RNA_pol_I-specific_init_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007224">
        <property type="entry name" value="TIF_Rrn11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28244">
        <property type="entry name" value="RNA POLYMERASE I-SPECIFIC TRANSCRIPTION INITIATION FACTOR RRN11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28244:SF1">
        <property type="entry name" value="RNA POLYMERASE I-SPECIFIC TRANSCRIPTION INITIATION FACTOR RRN11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04090">
        <property type="entry name" value="Rrn11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="273"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="277"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM27537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="431" mass="48745" checksum="466501C8E74F40AB" modified="2014-04-16" version="1">MAALSSSIFSLPLPPWLQPPGTRVSRYDRRKRKRSVGWSESELNGEETTDIASATESEPAGPPLVLTPNESHQYRIAGFPSNQELPKGHFPHKADNDEQSRRETASRHLKDLAGLSPPIYPPQSTQQGNLRFQHLSALTAILHRCMLQGDYVRAGRAWGMILREDYRGFRMDVRSEGRWGIGAEILLRRDEQEIPANLGTIKVPNAMDSTPINFTTKGFAAAKEYYERLILNHPFMKSSPQSISSLHFYPAMFGLWVYITQEESKATRKNITLRQEEEPDEFSEDDNSESEFGHPRKSQNKTDAAITAIRALELAQAQQIAARMDQLLGSPPYSDSPELLELRGMICLWIGDLLLLTLPLPAHFEDYDDHDPMLMDRTPGSLEARREHRLATEKKAAEVQRSIELFEKAKKRGRGVAYNLESLHIDDDSAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W6QDA5</accession>
    <name>W6QDA5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NUDIX hydrolase domain-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g001393</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QDA5"/>
    <dbReference type="STRING" id="1365484.W6QDA5"/>
    <dbReference type="OMA" id="WGNTWET"/>
    <dbReference type="OrthoDB" id="276276at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="79"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM27582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="283" mass="32574" checksum="DE99E9538798D887" modified="2014-04-16" version="1">MMAIYKCHGTLARSRIFFPILSYVDYTKQRRSTLGLPKRVNAAILNIPLDRLKELYPIQRFTAMAVTFSYHPDSPSKLRVLLILRNGKESSWGNTWETRGGTPDEEDPTIIHSAARESGEETQIWPSRIAGNAFTCSFYHEDRKTGDIVLMRTLGFTTIDNEETMAQRIWSSEMQQPVGQSSVKISHEHLDHCWFTEDEVRSAALYEQATPRRPFTMLRAKRDMVLLAFELFRKSQAKISIDLGYSTCPRSHVFLFNQSFHHECVSMRIRVSRYSTQSPDAGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W6QDD0</accession>
    <name>W6QDD0_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Tetratricopeptide-like helical</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PROQFM164_S03g001423</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sel-1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QDD0"/>
    <dbReference type="STRING" id="1365484.W6QDD0"/>
    <dbReference type="OMA" id="MDLQARK"/>
    <dbReference type="OrthoDB" id="27934at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050767">
        <property type="entry name" value="Sel1_AlgK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11102">
        <property type="entry name" value="SEL-1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11102:SF147">
        <property type="entry name" value="SEL1L ADAPTOR SUBUNIT OF ERAD E3 UBIQUITIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004881487" evidence="4">
        <location>
            <begin position="21"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="761"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="788"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="788"/>
            <end position="811"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDM34698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="832" mass="93016" checksum="5CAD645D4D7E772B" modified="2014-04-16" version="1">MRTPLSHFLSALLLLQTCAAGPGQPLTDQTASAATGRDADHEFTFLAGEAEPRPMTQRVENAWNTLRTIKNPVLQSDKSRGLLGTVTYYGRQTVRLLFLNRPSTEKPEQKINKHLTGAVEELRIAADEDRDPDAMFLLAEMNFYGNFSHPRDFKEAFRWYHELAWLDGNNTAQNMVGFMYATGIGGAVEPDQAKALMYHEFAAETGNIRSEMTLAYRYHTGIGTPKDCDHAIHYYKKVADKAVEYYRSGPPGGRSMVRESYRWADEEGGVYGPGASVSSSGQNARDAANASPEASVEDILEYLDLMSRKGELKATYTLGKMNFEGARGLPRNFRLAMKHFKVVTKKYWNKDGSVNSNPPAGLDKLASKAAGHIGLMYLRGEGVKQHFPTALTWFRRGITNGDPMCQHWMGLMYLKGYGIPQDAFKASHYFKAAAEQDSPASESRLGALFLDQGDVATATRYFELAARWGWMEAYYYLAEMANFGIGRQRHCGVAAAYYKMVAEKAEIVHSAFVEANAAYETGDKEGALIPSMMAAEQGYENAQANVAYLLDEHRSVLSLNSILPWAEKARSSLMRNARLALIYWTRSSKQANIDSLVKMGDYYLSGTGTPIDADKASTCYHNAAEAHHSAQGYWNLGWMHENGVAVDQDFHMAKRYYDLALDLSPEAYLPVKLSLIKLRARGYWNRITNGDINPIHEEEDSKPRRTFKEWVKAFIENDEDGYYEDLYELQRGDDDEYRGLESEGHEDGYYDDLDLDIDEGMLEGLLIVGLAAALLVLVYYRQQQQRNRQNQNANANANANAPNGDGNANDRGLFPQPGEPDFGQWVAGGVGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>W6QE42</accession>
    <name>W6QE42_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Zinc finger, RING/FYVE/PHD-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PROQFM164_S01g001663</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 16">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ubiquitin conjugation factor E4 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QE42"/>
    <dbReference type="STRING" id="1365484.W6QE42"/>
    <dbReference type="OMA" id="WLTEIAM"/>
    <dbReference type="OrthoDB" id="20295at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034450">
        <property type="term" value="F:ubiquitin-ubiquitin ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16657">
        <property type="entry name" value="RING-Ubox_UBE4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000055">
        <property type="entry name" value="Ubiquitin conjugation factor e4 a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019474">
        <property type="entry name" value="Ub_conjug_fac_E4_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045132">
        <property type="entry name" value="UBE4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003613">
        <property type="entry name" value="Ubox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13931:SF2">
        <property type="entry name" value="UBIQUITIN CONJUGATION FACTOR E4 B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13931">
        <property type="entry name" value="UBIQUITINATION FACTOR E4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04564">
        <property type="entry name" value="U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10408">
        <property type="entry name" value="Ufd2P_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00504">
        <property type="entry name" value="Ubox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51698">
        <property type="entry name" value="U_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0697">Rotamase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="U-box" evidence="13">
        <location>
            <begin position="966"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="796"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="503"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="73"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="83"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="796"/>
            <end position="807"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDM27852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="1054" mass="120175" checksum="6FDA155EBB8D998B" modified="2014-04-16" version="1">MSDTLSDADKIRNKRLAKLSNPGQSSDGASESTQSSSNTSPSQSPLSVQPPSRLFNAPPTPQQSEGKRIKITPAAASSEQPRPAAPSAPSTPPPQKIESIEAFEDRTLSAVFRVTLKEEGHRDIHGSRTYLPGLRSELQDEGQDLRIQVEVLDQALLEAASKAEKQRPLDYLLPCWKRITKLYKGLRRTGDDDPKYQVLCEARRLCMSYCIFAITMPEMFGSEWSPQSSLASYLLIDPEDDRGIDFEFINEAVRRFDEDDSVKPAFISAVEQLSAQLSSMDVNDDYKPYAIALRNLVRHGSIAAAITESSIFNNTRDPAQFEKATLLGPWFRLSPLQANVTLSYFSSPKTRDQAYISNAQRSLRMTQQMLSSDLLDVINHLIRASKEARDRVLDWFATAMNINHKRRAMQVDPAQVSSDGFMFNITTCLDQLCEPFMDAAFTKIDRVDADYLHRDSRVDMRDETKINADQHASDAFYSKKVEGTSNFITEVFFLTVAAHHYGSESLTSKMEQLEKDVRQMESTITKFELERVRWLNNPQQLRTFDTALKKYKDKLELGIALKYSLQGVLFDEQWQARSMLFMRYVTVWLLRLVSGKNFPKEQVTLPLPEEQPEVFKCLPEYFLEDVVSNFKFIMWCMPQIITATQGDELVMLCITFLECSTYIKNPYLKAGLISILFRGTWKRPGGASGVLVDLLNSMPFANEHLLHAVMKFYIEAEFTGTHSQFYDKFNIRYEIFQIIKCIWPNTLYREKLSLQANQNLDFFVQFVNLLLNDVTYVLDESFGAFKTIHNTQTELNTQGNSMDAATRQQREENLSSAQRSAKSYMQLTNQTVAMLKLFTEALADSFTMPEIVQRLADMLDYNLDAMVGPKSSNLRVDNLQEYGFNPRALLSEIVDVYLNLIGKENFILAVARDGRSYKPANFEKAADIIRKWSLKSPEQLHHWSELQKKVQAAKEADDQAEEDMGEIPEEFLDPLMYSLMDDPVILPSSRIAIDRATIRSHLLSDPHDPFNRVPLKIEDVVADTELKAKIEAFKNEKLAGKRREMVHDRMDTSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W6QEP2</accession>
    <name>W6QEP2_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Oligopeptide transporter OPT superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PROQFM164_S03g001662</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QEP2"/>
    <dbReference type="OMA" id="MTFDWAQ"/>
    <dbReference type="OrthoDB" id="9986677at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004648">
        <property type="entry name" value="Oligpept_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00727">
        <property type="entry name" value="ISP4_OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22601">
        <property type="entry name" value="ISP4 LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="173"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="303"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="327"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="367"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="404"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="437"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="608"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="635"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="717"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="789"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="836"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="864"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="559"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="125"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDM34935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="925" mass="103402" checksum="5763A864B2CA22D3" modified="2014-04-16" version="1">MSGAPLLRSSPVLGAPSYGALRDPDGSEEDTPVSRGPKVRGGLHRASFGDGIGSSSNVPGSTPRRSHSFVRQRNSLYAERNRRPSSAASDVGMGPDSKYSFATGLAVPGNPVMQETPASSPYMTSDDENVLDIDDDDSKSSDEDPPDNSPYAQVRASVPATDDFSLSINTPRMWILSLLFSLTGSAANLFFSLRYPSVAITPIIALVLVHPLGKFWDLIFRQTGDPLEFFENGTLHHRESLSGDIEAPPVPLASRVRLWFAQGRWNEKEHACVYISSNVSFGFAFATDVIVEQHKFYNQDVPIIYQLLLIISTQVLGYAFAGLTRRFLVRPSAMIWPGTLMSTAMFSTMHKSVNKKANGWSISRYKFFVVVWAGAFLWYFVPGLLMPALSYFNVITWLAPKNVVISNLFGVASGLGMFPLTFDWAQIAYIGSPLLTPWWAAANIVTGLVVVIWIAAPILYYKNVLFSAYMPIVSTAVFDNSGRPYNVSRILTTDFLFDEKAYQDYSPVYLPITYVLSYGVQFAALTSLVSHTICWYGKDIWQQTRKAFEEKRQVPDMETYQPLRGSNDAPRQSYEIPRTSSREASQDIPLGGEDVHCRLMRRYKDAPLMWYLVVFVSMLVIAIFTVEYYPTHLPWYGLLLALGITSVFFIPVGIIMAVTNQHSSLYLICQLLCGIVFPGRPVANMIFVTYSYISSAQGIKFSSDLKLGHYMKIPPRILFGVQMMATLVSSLTQIGVLNWMFTFVPGLCTPEAINGFNCPIARVHFNGSILWGVVGPQRFFGPGGLYRPLVWAFLIGAIAPLGAWLLGRHSKKSFWRMVNFPILFGSLSWIPPATGLNFSIWALVCFVFNYVIRRRRTAWWEKYAMTLSAALDSGLAFSVVVVFFAFIYPGWVDGFKWWGTEIYKQGCDWIACPYKPLEPGQRFGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W6QFG5</accession>
    <name>W6QFG5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Cation/H+ exchanger</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PROQFM164_S04g000429</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the fungal Na(+)/H(+) exchanger family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QFG5"/>
    <dbReference type="STRING" id="1365484.W6QFG5"/>
    <dbReference type="OMA" id="FFGIRGI"/>
    <dbReference type="OrthoDB" id="5327978at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015385">
        <property type="term" value="F:sodium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120029">
        <property type="term" value="P:proton export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042391">
        <property type="term" value="P:regulation of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036376">
        <property type="term" value="P:sodium ion export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1530.20:FF:000015">
        <property type="entry name" value="Na(+)/H(+) antiporter 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004712">
        <property type="entry name" value="Na+/H+_antiporter_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31382">
        <property type="entry name" value="NA(+)/H(+) ANTIPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31382:SF1">
        <property type="entry name" value="SODIUM ION_PROTON EXCHANGER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0050">Antiport</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="10" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="105"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="133"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="171"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="214"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="257"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="310"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="340"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="372"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="418"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="13">
        <location>
            <begin position="26"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="467"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="499"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="537"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDM35548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="546" mass="60135" checksum="9BF48D967D0C4BEB" modified="2014-04-16" version="1">MPTLALINFNIVCATLGGFVSLFGLVSYLCKEQFYLSEALISLLAGVLFSPHAANFIRPDDYALHSEENLEVITLHFTRLVLGVQLVLAGVQLPKRYLQIEWRSLGLLLGPGMAAMWMCSSLLIWAMVPNFKFLHALVVGACVTPTDPVLSNSIVKGKFADKHVPRELQRIIIAESGANDGLGYPFLFFAIYLLQYTGMGSQSYSGGAGKAMALWFYETWAYTILLSIVYGTVVGWIARKLLHWAEEKRYVDRESFLVFAIALALFIVGTCGLIGTDDLLACFIAGNVFTQDDWFRLETIDDSLQPTIDMLLNLSVFMWFGAVCPWSSFLNNSVIPINRLIFLGILILLVRRLPIVLAMYKWIPQIDLVSQAAFVGFFGPIGVGAIFYLSISREFLRKIQVDGEVPGDVKQVMETIQVVVWFLVICSIVVHGLSVPIGKAGYHLPSTISSVISTSTYEGPEPVPISTISHTHSTATPLTTGEDASYRSRKRGFRGANPSSSFFGIGSSVIHPRPRSPFQQPGVGQPESERPAHLVIHQTTGGDNKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>W6QG31</accession>
    <name>W6QG31_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="28">Fatty acid synthase subunit beta</fullName>
            <ecNumber evidence="6">1.3.1.9</ecNumber>
            <ecNumber evidence="8">2.3.1.38</ecNumber>
            <ecNumber evidence="9">2.3.1.39</ecNumber>
            <ecNumber evidence="5">2.3.1.86</ecNumber>
            <ecNumber evidence="4">3.1.2.14</ecNumber>
            <ecNumber evidence="7">4.2.1.59</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="33" type="primary">FAS1</name>
        <name evidence="33" type="ORF">PROQFM164_S03g001658</name>
    </gene>
    <organism evidence="33 34">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="33" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="33">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="27">Fatty acid synthetase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. The beta subunit contains domains for: [acyl-carrier-protein] acetyltransferase and malonyltransferase, S-acyl fatty acid synthase thioesterase, enoyl-[acyl-carrier-protein] reductase, and 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>(9Z)-octadecenoyl-[ACP] + H2O = (9Z)-octadecenoate + holo-[ACP] + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15057"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9924"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78783"/>
            <dbReference type="EC" id="3.1.2.14"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a (3R)-hydroxyacyl-[ACP] = a (2E)-enoyl-[ACP] + H2O</text>
            <dbReference type="Rhea" id="RHEA:13097"/>
            <dbReference type="Rhea" id="RHEA-COMP:9925"/>
            <dbReference type="Rhea" id="RHEA-COMP:9945"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:78784"/>
            <dbReference type="ChEBI" id="CHEBI:78827"/>
            <dbReference type="EC" id="4.2.1.59"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>a 2,3-saturated acyl-[ACP] + NAD(+) = a (2E)-enoyl-[ACP] + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10240"/>
            <dbReference type="Rhea" id="RHEA-COMP:9925"/>
            <dbReference type="Rhea" id="RHEA-COMP:9926"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:78784"/>
            <dbReference type="ChEBI" id="CHEBI:78785"/>
            <dbReference type="EC" id="1.3.1.9"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>acetyl-CoA + n malonyl-CoA + 2n NADPH + 4n H(+) = a long-chain-acyl-CoA + n CoA + n CO2 + 2n NADP(+).</text>
            <dbReference type="EC" id="2.3.1.86"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>holo-[ACP] + acetyl-CoA = acetyl-[ACP] + CoA</text>
            <dbReference type="Rhea" id="RHEA:41788"/>
            <dbReference type="Rhea" id="RHEA-COMP:9621"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78446"/>
            <dbReference type="EC" id="2.3.1.38"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>holo-[ACP] + malonyl-CoA = malonyl-[ACP] + CoA</text>
            <dbReference type="Rhea" id="RHEA:41792"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="EC" id="2.3.1.39"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="21">[Alpha(6)beta(6)] hexamers of two multifunctional subunits (alpha and beta).</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 29">Belongs to the fungal fatty acid synthetase subunit beta family.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.9" evidence="6"/>
    <dbReference type="EC" id="2.3.1.38" evidence="8"/>
    <dbReference type="EC" id="2.3.1.39" evidence="9"/>
    <dbReference type="EC" id="2.3.1.86" evidence="5"/>
    <dbReference type="EC" id="3.1.2.14" evidence="4"/>
    <dbReference type="EC" id="4.2.1.59" evidence="7"/>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1365484.W6QG31"/>
    <dbReference type="OMA" id="HFMDNYG"/>
    <dbReference type="OrthoDB" id="5417908at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005835">
        <property type="term" value="C:fatty acid synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019171">
        <property type="term" value="F:(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004313">
        <property type="term" value="F:[acyl-carrier-protein] S-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004314">
        <property type="term" value="F:[acyl-carrier-protein] S-malonyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004318">
        <property type="term" value="F:enoyl-[acyl-carrier-protein] reductase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016297">
        <property type="term" value="F:fatty acyl-[ACP] hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004321">
        <property type="term" value="F:fatty-acyl-CoA synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03447">
        <property type="entry name" value="FAS_MaoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.120:FF:000001">
        <property type="entry name" value="Fatty acid synthase beta subunit dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.930.70:FF:000001">
        <property type="entry name" value="Fatty acid synthase beta subunit dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.129.10:FF:000017">
        <property type="entry name" value="Fatty acid synthase beta subunit dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000078">
        <property type="entry name" value="Fatty acid synthase beta subunit dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1120.100:FF:000001">
        <property type="entry name" value="Fatty acid synthase beta subunit dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.366.10:FF:000006">
        <property type="entry name" value="Fatty acid synthase beta subunit dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.366.10:FF:000007">
        <property type="entry name" value="Fatty acid synthase beta subunit dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.129.10:FF:000015">
        <property type="entry name" value="Fatty acid synthase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000169">
        <property type="entry name" value="Fatty acid synthase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.3330:FF:000001">
        <property type="entry name" value="Fatty acid synthase subunit beta dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.366.10:FF:000003">
        <property type="entry name" value="Fatty acid synthase subunit beta dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1400">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.60.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.240.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039569">
        <property type="entry name" value="FAS1-like_DH_region"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016452">
        <property type="entry name" value="Fas1/AflB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013565">
        <property type="entry name" value="Fas1/AflB-like_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041099">
        <property type="entry name" value="FAS1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040883">
        <property type="entry name" value="FAS_meander"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003965">
        <property type="entry name" value="Fatty_acid_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050830">
        <property type="entry name" value="Fungal_FAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002539">
        <property type="entry name" value="MaoC-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032088">
        <property type="entry name" value="SAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10982:SF21">
        <property type="entry name" value="FATTY ACID SYNTHASE SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10982">
        <property type="entry name" value="MALONYL COA-ACYL CARRIER PROTEIN TRANSACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08354">
        <property type="entry name" value="Fas1-AflB-like_hel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13452">
        <property type="entry name" value="FAS1_DH_region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22235">
        <property type="entry name" value="FAS1_thioest_ins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17951">
        <property type="entry name" value="FAS_meander"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17828">
        <property type="entry name" value="FAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01575">
        <property type="entry name" value="MaoC_dehydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16073">
        <property type="entry name" value="SAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005562">
        <property type="entry name" value="FAS_yeast_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01483">
        <property type="entry name" value="FASYNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51412">
        <property type="entry name" value="Inosine monophosphate dehydrogenase (IMPDH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="18" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="13" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="12 29" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="17" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="19" id="KW-0456">Lyase</keyword>
    <keyword evidence="20" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="16 29" id="KW-0520">NAD</keyword>
    <keyword evidence="14 29" id="KW-0521">NADP</keyword>
    <keyword evidence="15 29" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="34" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 29" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Malonyl-CoA:ACP transacylase (MAT)" evidence="32">
        <location>
            <begin position="1689"/>
            <end position="2010"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="31">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="active site" description="For acetyltransferase activity" evidence="30">
        <location>
            <position position="285"/>
        </location>
    </feature>
    <feature type="active site" description="For malonyltransferase activity" evidence="30">
        <location>
            <position position="1833"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00013256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00013258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00033756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00048237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00048462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00048536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00048572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00048835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00058855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00068309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="PIRNR" id="PIRNR005562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="PIRSR" id="PIRSR005562-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="32">
        <source>
            <dbReference type="SMART" id="SM00827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="33">
        <source>
            <dbReference type="EMBL" id="CDM34931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="34">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="2082" mass="231044" checksum="D6419B70B4319714" modified="2014-04-16" version="1">MYGTLTGPQTGINTPRSSQSLRPLTLSHGSLEFSFLVPTSLHFHASQLKDSFTASLPEPTDELAQDDEPSSVTELVARYIGHVAHEIEDEDDAQGNYLEVLKLALNEFERAFMRGNDVHAVAAALPGIVAKKNQVVEAYYAGRAAAGRPTKPYDSALFRAASDEAAGIYSVFGGQGNIEEYFDELRNIYTTYPSFVEELITSSAELLQTLSHEPEASKLYPKGMDILQWLQDRDAQPDIDYLVSAPVSLPLIGLVQLSHYMVTCKVLGRQPGDILGRFLGTTGHSQGVVTAAAIATATSWESFATAARNALTMLFWIGLRSQQAYPRTSIAPSVLQDSVENGEGTPTPMLSIRDLSLAAVQEHIDATNQHLPEDRHISISLVNSARNFVVTGPPISLYGLNVRLRKVKAPTGLDQNRVPFTQRKVRFVNRFLPITAPFHSQYLVSAYDRILEDLEDVVEISAKSLEIPVFHTKTGEDLRQLGDKDIVPALVRMITHDAVNWEKATVFPHATHILDFGPGGISGLGVLTNRNKDGTGVRVILAGEMDGTNAEVGYKPELFDRDEHSVKYAVDWVKEHGPRLTKTSTGQTYVDTKMSRLLGIPPVMVAGMTPTTVAWDFVAATMNAGYHIELAGGGYYNAKTMTEAITKIEKAIPPGRGITINLIYVNPRAMAWQIPLIGRLRAEGVPIEGLTIGAGVPSIEVANEYIETLGIKHIAFKPGSVDAIQQVINVAKANPKFPIILQWTGGRGGGHHSFEDFHQPMLQMYSRIRKQDNIVLVAGSGFGGSQDTYPYLSGTWSAKFGYPPMPFDGCLFGSRMMIAKEAHTSHNAKKAIADAPGVDDAEWEKTYQKSTGGVITVLSEMGEPIHKLATRGVLFWQEMDQKIFKLDKAKRVPELKKQRNYIIKKLNDDFHKVWFGRNAAGETVDLEDMTYAEVVHRMVDLMYIKHESRWIDASLKRLTGDFIRRVEERFTTAEGQASLLQSYSDLDTPYPTVDNILSAYPEAANQLINAQDVQHFLLLCQKRGQKPVPFVPVLDENFEFFFKKDSLWQSEDLEAVVDQDVGRTCILQGPVAARFSNIIDEPVKDILDGVHQGHIAGLLRDVYGGDSTKIPVIEYFGGQLTNTTELESDDLVISEEPSKTSFRLSSTAALPDLDRWLGLLAGNVYSWRHALFLADVFVQGHRFQSNPMKRIVAPTAGMYVEISNPNDPAKTVISVREPYQSGKLVKTVEAKINEKGQIMLTLIEGRTAENGVVPLNFLFTYHPETGYAPIREVMGDRNDRIKEFYYRIWFGNKDVPFDTPTTATFSGGQKTITAQDVADFVHAVGNTSEAFVDRPGKEVFAPMDFAIVAGWQAITKPIFPRTIDGDLLKLVHLSNGFKMVPGAQPLKVGDVLDTTAQINSIINQDSGKMVEVCGTIRRDNKPIMHVTSQFLYRGSYVDYENTFQRKDEVPIQVHLATSRDVAILRSKEWFRMDDSDVELLGQTLTFRLQSLIRFKNTTVFSNVQTVGQVLLELPTKEIIQVASVEYEAGDSHGNPVIDYLQRNGTSIEQPVYFENPIPLSGKTALELRAPASNETYARVSGDYNPIHVSRVFSSYANLPGTITHGMYSSAAVRSLVETWAAENNIGRVRGFQVSLVGMVLPNDIITVKLQHVGMIAGRKIIKVEASNKETEEKVMEGEAEVEQPVTSYVFTGQGSQEQGMGMELYGSSPVAQEVWDRADRHFMENYGLSIIDIVKNNPKELTVYFGGPRGKAIRENYMAMTFESVNADGSIKSEKIFKEVDENTASYTYRSPTGLLSATQFTQPALTLMEKASFEDMRTKGLVQRDSSFAGHSLGEYSALAALADVMPIESLVSVVFYRGLTMQVAVERDAQGRSNYSMCAVNPSRISKTFNEQALQYVVENISETTGWLLEIVNYNVANMQYVAAGDLRALDCLTNLLNFLKAQNIDIPALMESMSLEDVKDHLVSIIQECVKQTEAKPRPINLERGFATIPLKGIDVPFHSTFLRSGVKPFRSFLLKKINKTTIDPSKLIGKYIPNVTARPFEITKEYFEDVYRLTNSPRIASILANWEKYEEGSENVPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W6QG91</accession>
    <name>W6QG91_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Actin cytoskeleton-regulatory complex protein END3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Actin cytoskeleton-regulatory complex protein end3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">Cytoskeletal adapter protein sagA</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">Endocytosis protein 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">PROQFM164_S01g002473</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="19">Component of the PAN1 actin cytoskeleton-regulatory complex required for the internalization of endosomes during actin-coupled endocytosis. The complex links the site of endocytosis to the cell membrane-associated actin cytoskeleton. Mediates uptake of external molecules and vacuolar degradation of plasma membrane proteins. Plays a role in the proper organization of the cell membrane-associated actin cytoskeleton and promotes its destabilization.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the PAN1 actin cytoskeleton-regulatory complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Actin patch</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the END3 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QG91"/>
    <dbReference type="STRING" id="1365484.W6QG91"/>
    <dbReference type="OMA" id="DWLIPES"/>
    <dbReference type="OrthoDB" id="1716625at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00052">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000323">
        <property type="entry name" value="Actin cytoskeleton-regulatory complex protein end3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000339">
        <property type="entry name" value="Actin cytoskeleton-regulatory complex protein END3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000261">
        <property type="entry name" value="EH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025604">
        <property type="entry name" value="End3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11216">
        <property type="entry name" value="EH DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12763">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12761">
        <property type="entry name" value="End3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00027">
        <property type="entry name" value="EH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50031">
        <property type="entry name" value="EH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="17" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="14" id="KW-0106">Calcium</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="18" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="13" id="KW-0967">Endosome</keyword>
    <keyword evidence="16" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EH" evidence="23">
        <location>
            <begin position="10"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="24">
        <location>
            <begin position="42"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="EH" evidence="23">
        <location>
            <begin position="139"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="306"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="22">
        <location>
            <begin position="306"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00017312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00025194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00029684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00032224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="CDM28662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="404" mass="46457" checksum="E30D265E3674229C" modified="2014-04-16" version="1">MATKKIEQWEIERYWEIFASLSNGQKHLNSSQAASVLRNSRLRDDQLEKVWDIADVDGDGELDFEEFCVAMRLVFDLVNGELQDVPNVLPDWLVPESKAHLVHATRALSSGQEQFERIEDEDDSLGLKDGFDWYMKPDDKNKYAEIYDANRNARGQIEFQQLQPLYESLDVPDTDVRSAWNLVNPSASPAINKDATLAFLHILNFRHEGFRIPRTIPASLRASFEHNQIDYQVDKARPAQRYGVDGDTETRSGRKAKFGDTYLGRLGVGGKGSYQPKGTDFSDTIQDEEWEKVRLRRELAELEKKLESANKASESRRDGPRNDGRPNWVLIKKEALSLLEYKERELRELREGTGRAKDGQDLERLREDVKAVGEQVEGLKKHMAQRHDVLSDLRSQIEDEKARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W6QGD0</accession>
    <name>W6QGD0_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosomal protein S36, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PROQFM164_S03g001758</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the alpha-ketoglutarate dehydrogenase component 4 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM35031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QGD0"/>
    <dbReference type="STRING" id="1365484.W6QGD0"/>
    <dbReference type="OMA" id="PDSFVTY"/>
    <dbReference type="OrthoDB" id="2116030at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004591">
        <property type="term" value="F:oxoglutarate dehydrogenase (succinyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006103">
        <property type="term" value="P:2-oxoglutarate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020373">
        <property type="entry name" value="Kgd4/YMR-31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31601">
        <property type="entry name" value="28S RIBOSOMAL PROTEIN S36, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31601:SF2">
        <property type="entry name" value="ALPHA-KETOGLUTARATE DEHYDROGENASE COMPONENT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10937">
        <property type="entry name" value="Kgd4-YMR31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="26"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00043970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDM35031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="119" mass="12676" checksum="6FBEF048C94C4675" modified="2014-04-16" version="1">MRATSILRSAARTPLIHFIGKRSVPKSIDHSPRVHPASPTGSLPDSFATYRAKAQQHGPLGRSSFNGTIGGHSGASLGPVKPQEGEFFDRAELPARFGRLPWTEAEIEAIETGGASLFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W6QGM8</accession>
    <name>W6QGM8_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Peptide hydrolase</fullName>
            <ecNumber evidence="15">3.4.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">PROQFM164_S03g000058</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">May be involved in vacuolar sorting and osmoregulation.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Vacuole membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the peptidase M28 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="15"/>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QGM8"/>
    <dbReference type="STRING" id="1365484.W6QGM8"/>
    <dbReference type="OMA" id="TPWPVTI"/>
    <dbReference type="OrthoDB" id="76293at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03875">
        <property type="entry name" value="M28_Fxna_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000057">
        <property type="entry name" value="Vacuolar membrane protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048024">
        <property type="entry name" value="Fxna-like_M28_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045175">
        <property type="entry name" value="M28_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053975">
        <property type="entry name" value="PFF1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053976">
        <property type="entry name" value="PFF1_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147">
        <property type="entry name" value="METALLOPEPTIDASE M28 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147:SF58">
        <property type="entry name" value="VACUOLAR MEMBRANE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22250">
        <property type="entry name" value="PFF1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22251">
        <property type="entry name" value="PFF1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 21" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6 15 21" id="KW-0645">Protease</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0926">Vacuole</keyword>
    <keyword evidence="10 15" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="384"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="439"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="470"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="502"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="534"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="651"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="688"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="716"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M28" evidence="18">
        <location>
            <begin position="159"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="Vacuolar membrane protease transmembrane" evidence="20">
        <location>
            <begin position="437"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="domain" description="Vacuolar membrane protease C-terminal" evidence="19">
        <location>
            <begin position="743"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="573"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="582"/>
            <end position="595"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU361240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF22250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF22251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="CDM33334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="987" mass="110176" checksum="BFC5054A16E4F7AC" modified="2014-04-16" version="1">MATQKARNPLAFTPWPVTIITTVVYLALIIPLLVIHHIVPPAPQTSPNGLNLTEAWQDLQSLTTGFHPYNSHQNDVVRSWLLERIDAIKQSAASTEEYRDAKEEKPDVFVFDDLVSNLTFIDKSVGVYFEGTNILVYIRGSEDSKQNWWETPGRVPVGKGGVLVNAHYDSVSTGYGATDDGVGVVTCLQLVKYFLTPGHAPRRGLVVLFNNGEEDYLNGARAYSQHPMALFAHTFLNLEGAGAGGRATLFRSSDTEVTQAYAKSQHPFGSVLSANGFEKGLIGSQTDYIVLEGILGLRGLDVAFFEPRARYHTDQDDARHTNIDSLWHMLSTAVATTEELLSDATDRFDGHLRDDGNVPSGSGTRAVWFDLFGSAFAIFRLHTLFALSVTLLIVAPLTLLITSIILSRADKMYLFRSSVYSEINDDNIPLRGLRGFFRFPFLLLIPTAVTVGLAYMVTKVNPFIAHSSSYAVWSMMISAWIFLAWFVSRIADFARPSAFHRVYTWTWMFVLTWSLMVVGTVYEHEEGLAGGYFMFFYFAGTFLATWISYLELFSLPTKSEYAARLFESRRPSTQGSRLATSGDEDQDDDTEEDLTESTSLLHGRHRPTFANYVRVGVDRGSHEQDEEDEEKDPNVYEDEQGWSGVLPRWTWLLQLLITAPVILMLIVPLALLITSALSQTGQDGNPQLIVYLFISSLTVLLFAPILPFIHRYTYHLPIFLLFVFIGTLIYNLVAFPFADSNRLKLFFLQEVDLDNGMSTASLTGMPPFVKEVTYGLPSAAGQNEACDWIFRGSNRVQRCSWNAPIPHVVPSPESLSLPNEGADSLLEASELSPDWISFNISHPQSDSSSVRFEVSGQNTRNCRINMDGNYITDFSVVGSSAPDQRFINPSPDGLSRIQLWSRTWDNKWTVDVDFSKHESSEADGNSSITGRITCLWSDNNRIGLIPALDEVRQFSPAWVAVTKFSDGLIEGSRAFEIKRSSLGTLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W6QH18</accession>
    <name>W6QH18_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13">Telomerase reverse transcriptase</fullName>
            <ecNumber evidence="2 13">2.7.7.49</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Telomerase catalytic subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PROQFM164_S01g002718</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Chromosome</location>
            <location evidence="13">Telomere</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 13">Belongs to the reverse transcriptase family. Telomerase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.49" evidence="2 13"/>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QH18"/>
    <dbReference type="STRING" id="1365484.W6QH18"/>
    <dbReference type="OMA" id="FDTIPQE"/>
    <dbReference type="OrthoDB" id="289721at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000333">
        <property type="term" value="C:telomerase catalytic core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003720">
        <property type="term" value="F:telomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070034">
        <property type="term" value="F:telomerase RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007004">
        <property type="term" value="P:telomere maintenance via telomerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01648">
        <property type="entry name" value="TERT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021891">
        <property type="entry name" value="Telomerase_RBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003545">
        <property type="entry name" value="Telomerase_RT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049139">
        <property type="entry name" value="TERT_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12066">
        <property type="entry name" value="TELOMERASE REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12066:SF0">
        <property type="entry name" value="TELOMERASE REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12009">
        <property type="entry name" value="Telomerase_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21399">
        <property type="entry name" value="TERT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01365">
        <property type="entry name" value="TELOMERASERT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00975">
        <property type="entry name" value="Telomerase_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 13" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 13" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 13 16" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="9 13" id="KW-0779">Telomere</keyword>
    <keyword evidence="5 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="15">
        <location>
            <begin position="692"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="259"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="389"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="14"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="266"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU365061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CDM28907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="1229" mass="138854" checksum="E351FD0AFE301BCF" modified="2014-04-16" version="1">MGKKRKRPIKDRGSTSSSHTGITTSPRRFRPPHAPIPLGTKTSHPVISLYYRNVVPLREYLLHKLPVTSKSRRRRILTLGSREDQGTNAQLQTSETLAELLDSTLVGVLKESSPTLNYERQKQYSSFNESQSRSILVSTDTGPTCPQLEVVDFVIWKIFNRSNGYSKEAKHLLTHGFKRMSMHHAQHTGIPGIVSQFPNQNVQVLKKGAWAEVLGLLGSNGEEIMMQLLFDCGVFAPIDAENGIYYQLSGIPLSDLEPLSDASAEANGSTATAQDSMPTAGQRHPKEKAEYKQSSEMLQSPNNIVFMRRRILYGRVESKKGVASGLGQKHVLGRFSTLDSMAQTVHVMKYIFPRQFGLLNVFTLDSDQRKQMNDSNGFMSRESEISLLEEQKRPQGPQTGSESADAGCGGVKSVKVPKRLRGITIELVRKLRNRNAQCSYGELLRYYCPTEQTEPRLLGAFVSTTDAKKSEPISSLESNFVTQVNYPSPSDSSQTSCDGARSEPHIAVDTSCGNDAEKPVIRKTQVSLTDHATPPSSVSAFCRAVIQKLIPRQFWGVGPDGISNFKLVLRHVDRFIKLRRFESLSLHEVCKGVKITSIPWLAPPQVQTSLPSETRSKIALSDLHKRTELLHEFMFWIFDSLLIPLIRSHFYVTESQVHRNRLFYFRHDVWQQLTQQPFGDLKAMMFEELESDQAQRVLARRSFGFGALRLLPKSTGIRPILNLRKRDLKTRSWGKRETYLGISINSSITPIYNMLTYEREQAPAKLGSSILSVADMHRRLKAYKEQLSQRLPSASRPWQSKLPPMYFVKVDIKACFDTIPQKKLLNLIEELVSEESYCIAKHTEIHPPTSTAKQGKPIRRFLSRATPAMKPQHLPDYVNSESTTRKANTVFVECGQKENDADSLLELLSEHVQNNLVKIGKRFFRQRNGIPQGSVLSSLLCNFFYAELERKVLNFIKPEDSLLLRLVDDFLLVTPDVAVAMQFLEVMIRGQPSYGVQVNPAKSMANFSAAVDGILLPRLEGSTLFPYCGSLIDTHTLEFHRDQDRILQGGESAAATLSDALTVEAARLPGRTFHRKMLSSFRLQLYSMYIDDGHNSRAVVLANLYCSFITAAMRMYRYMKSLRGRAHPGPAIITQTIRDLIRQTNRYIQARRAGNSESPFSCFVQRSHLQYLASAAFRFVLKRKQTRYAVVLRWLDSLSKDSRPTSDSEASRIAQVVKKGNAMFEEWRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W6QH87</accession>
    <name>W6QH87_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Luciferase-like domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S04g000207</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QH87"/>
    <dbReference type="STRING" id="1365484.W6QH87"/>
    <dbReference type="OMA" id="ERWVTEA"/>
    <dbReference type="OrthoDB" id="8922241at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="entry name" value="Luciferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051260">
        <property type="entry name" value="Diverse_substr_monoxygenases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30011">
        <property type="entry name" value="ALKANESULFONATE MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30011:SF30">
        <property type="entry name" value="XENOBIOTIC COMPOUND MONOOXYGENASE, DSZA FAMILY (AFU_ORTHOLOGUE AFUA_6G01920)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="Bacterial luciferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Luciferase-like" evidence="1">
        <location>
            <begin position="2"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM35326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="249" mass="27061" checksum="6FAF50A027163A5C" modified="2014-04-16" version="1">MPTQRTPFLFQAGTSPAGVAFGAKHAEGIFVSAPSPHILAPRIKAIREEAAKLGRDPKSVKVFAILTPIVGRTDEEAQAKYREALEYASEEAGLAFFSGGSGIDLSRFDLDTPITPSDVHVDARVHSTINTLSYQSPDVPEWTPRNIGKHISIGGAGPVPVGSASTVADFLEEWVRVADLDGFNIGYVQTPGTFEDVVELLVPELRRRGVYAPLGESGTMRERVYGPGQRRLRDDHVGKKYGYEVYDGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W6QIC7</accession>
    <name>W6QIC7_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dihydrodipicolinate synthetase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S03g000678</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DapA family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QIC7"/>
    <dbReference type="STRING" id="1365484.W6QIC7"/>
    <dbReference type="OMA" id="QAIKLSM"/>
    <dbReference type="OrthoDB" id="191315at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008840">
        <property type="term" value="F:4-hydroxy-tetrahydrodipicolinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00408">
        <property type="entry name" value="DHDPS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128">
        <property type="entry name" value="DIHYDRODIPICOLINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128:SF24">
        <property type="entry name" value="DIHYDRODIPICOLINATE SYNTHETASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_3G11920)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001365">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00146">
        <property type="entry name" value="DHPICSNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="2">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="2">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR001365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR001365-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM33954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="335" mass="35625" checksum="81B164289035AE05" modified="2014-04-16" version="1">MSPTPLRPGVYAPTMTFFDAQTEDLDIPSIRRHAVRLAKAGLVGLVTMGSNGEAVHLSREERKTVNRETRSALDEAGFTNVPVIAGASENSIRGTIDLCKEVAESGGEYVLIVPPSYYRTAVGNDETLYEYFTAVADGSPVPIILYNYPGAVAGIDMDSDLIIRISEHPNIVGTKFTCANTGKLTRVATALGAITPPSPLAPAQRTATVSKPNAKHPYVAFGGIADFSLQTLVSGGSAILAGGANVLPRLCVRIFTLWSEGRLTEAIEAQQQLSAADWVLTKAAIPGTKGAIQSYYGYGGFPRRPLSRLTDAQYQAVADKIKPAMDVELSLPDVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W6QIE4</accession>
    <name>W6QIE4_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein YOP1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PROQFM164_S01g003159</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the DP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QIE4"/>
    <dbReference type="STRING" id="1365484.W6QIE4"/>
    <dbReference type="OMA" id="DTQYWVV"/>
    <dbReference type="OrthoDB" id="10009287at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004345">
        <property type="entry name" value="TB2_DP1_HVA22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12300">
        <property type="entry name" value="HVA22-LIKE PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12300:SF161">
        <property type="entry name" value="RECEPTOR EXPRESSION-ENHANCING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03134">
        <property type="entry name" value="TB2_DP1_HVA22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="37"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="88"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM29347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="171" mass="19394" checksum="0B49111679C1006D" modified="2014-04-16" version="1">MASFQERAQHSIAQLDKELSKYPVLANLERQTNVPKVYVILGLIGIYFFLVFFNIAGEFLVNFAGFLIPGYYSLNALFTSSTQDDTQWLTYWVVFAFLTVIESAISAAYWFPFYYIFKFVLIMWMALPQTSGAQIVFNSFLQPVLGRFFSSNGTSSNLRAQAEAASKPHST</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>W6QIT4</accession>
    <name>W6QIT4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter ATP-binding protein ARB1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ARB1</name>
        <name evidence="7" type="ORF">PROQFM164_S04g000792</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QIT4"/>
    <dbReference type="STRING" id="1365484.W6QIT4"/>
    <dbReference type="OMA" id="DWMGQWT"/>
    <dbReference type="OrthoDB" id="2110130at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03221">
        <property type="entry name" value="ABCF_EF-3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000549">
        <property type="entry name" value="ABC transporter ATP-binding protein arb1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000618">
        <property type="entry name" value="ATP-binding cassette (ABC) transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032781">
        <property type="entry name" value="ABC_tran_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050611">
        <property type="entry name" value="ABCF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211:SF15">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY F MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="77"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="388"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM35911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="609" mass="68022" checksum="97E5FF642DD53330" modified="2014-04-16" version="1">MVSASKAARMAKRADEKKPKKVTKVELDAHGNPIVEDAPATKDQSAVDKLTAQMDKHGLSDRVTTGVLSSLPASRDVKITSCSLVFHGKVLVTDSTLELTFGRRYGLLGENGCGKSTILKSIAAREFPVPEHIDIYLLNEGAPPTDFGALDWVVREAERQLEDMEKKAEEVLEESGPDNPILEDLYDRMDKMDPSTFHVRASLILTGLGFNKFTINKKTKDMSGGWRMRVALAKALFVKPSLLLLDDPTAHLDLEACVWLEEYLKKWDRTLILVSHSMDFLNGVCTTMLDMRGQKLLYYGGNYDSYHKTRSEQETNQAKAYTKQQEEIQHIKKFIASAGTYANLVRQAKSRQKILDKMEADGFIQPVVADRVFTFRFADVEKLPPPVLSFDDVSFSYSGKWEDTLYEHLDLGVDMDSRTALVGPNGVGKSTLLRLMTGKLSPIGGRVSRHTHLKLGVYSQHSSEQLDLTKSSLEFVRDRFPEKSQDYQYWRQQLGRYGLSGEGQTALMGTLSEGQKSRIVFALLAIESPNMILLDEPTNGLDIPTIDSLADAINAYSGGVVVVSHDFRLLDKIAKDIMVCEDKTIRRWDGSIGDYKNHLRNKMLSAGAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W6QJ80</accession>
    <name>W6QJ80_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NAD(+) diphosphatase</fullName>
            <ecNumber evidence="4">3.6.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PROQFM164_S01g003459</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a 5'-end NAD(+)-phospho-ribonucleoside in mRNA + H2O = a 5'-end phospho-adenosine-phospho-ribonucleoside in mRNA + beta-nicotinamide D-ribonucleotide + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:60876"/>
            <dbReference type="Rhea" id="RHEA-COMP:15698"/>
            <dbReference type="Rhea" id="RHEA-COMP:15719"/>
            <dbReference type="ChEBI" id="CHEBI:14649"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:144029"/>
            <dbReference type="ChEBI" id="CHEBI:144051"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:60877"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Nudix hydrolase family. NudC subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.22" evidence="4"/>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QJ80"/>
    <dbReference type="STRING" id="1365484.W6QJ80"/>
    <dbReference type="OMA" id="CNTRTTL"/>
    <dbReference type="OrthoDB" id="10249612at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035529">
        <property type="term" value="F:NADH pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019677">
        <property type="term" value="P:NAD+ catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006742">
        <property type="term" value="P:NADP+ catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03429">
        <property type="entry name" value="NUDIX_NADH_pyrophosphatase_Nudt13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.20:FF:000005">
        <property type="entry name" value="NADH pyrophosphatase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000042">
        <property type="entry name" value="Probable NADH pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050241">
        <property type="entry name" value="NAD-cap_RNA_hydrolase_NudC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015375">
        <property type="entry name" value="NADH_PPase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049734">
        <property type="entry name" value="NudC-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015376">
        <property type="entry name" value="Znr_NADH_PPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42904:SF6">
        <property type="entry name" value="NAD-CAPPED RNA HYDROLASE NUDT12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42904">
        <property type="entry name" value="NUDIX HYDROLASE, NUDC SUBFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09296">
        <property type="entry name" value="NUDIX-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09297">
        <property type="entry name" value="Zn_ribbon_NUD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="10">
        <location>
            <begin position="250"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDM29647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="415" mass="45720" checksum="FEF1842DED6EB847" modified="2014-04-16" version="1">MSTTALIPAPAHTLADSMLSRHFGKETVNYFSSSPINRLSFLRSDHPFLSSALKHPSTRFVLLNNLAPLTPSPSQLYYAKYDDVRKLVPQDIFDKSEEDMIKNYDSRKTHPTLIFLGLDESHKEGGLTYKIYSGTPYFAVDVTPKGPEEQQTAAKDIIAAMEAKGLSFFQTRVVMSFSADEAAIYAQARALMDWNTRNTFCGTCGHRTLAVNAGTKRACPPTDVALGIEGKLEERPECNTRTTLSNLSFPRTDPTIIVAVVSADGKRVLLGRSKRFPPGWYSTLAGFIEPAESIEDAVRREVWEESGVTLSRVVIHSSQPWPYPANLMIGAIAQVSDPAHETISLLHDPELEDARWFEIEEVQEALRIGTSDLSGPAGPEYKGGLRLPPPTAIANQLIQAAVSAEYFAADKQSKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W6QJE1</accession>
    <name>W6QJE1_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S05g000373</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QJE1"/>
    <dbReference type="OMA" id="NADEFTM"/>
    <dbReference type="OrthoDB" id="2143914at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="275"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="364"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="312"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="378"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="399"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="429"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM36540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="514" mass="55894" checksum="D8273741C99E2DDF" modified="2014-04-16" version="1">MAPINLDDVIHYRPPAKKPHFKPLRAPGSHDRIYSQIPLDRPAPAILSSQHWCSSLPFSGHAPYLQSHFHAPSEVETLLAPNELAEEVTIDSSNEFDMDFLNASSERDANVAISNIHTASRELPDDVSSSDLGQGLSDQLHDDFQGDEHHESNVTSSSQDIIQGGGLEQSTPLYSTSVRDGLCIPVAEGKILSRTEAYENADEFTMEGDILRHSNPTIDIADGNTMVNGQILDPAGQEKQSTPTHLLSGDAGIEADKLGLKPAACVIGESMPAEEYNRQPVSESQVVIGQEKDRAAAHDNKGELQHRHAESLSASPKPRQNGTLARSISPAFQNSEKQSPCSPTVEVTGFCPVLDQAPVLDQPSVVISNSRPQKRGTKNSVSITRMASPNRKRDRDEYISDDSSDDPDGSDDADYVGESGEDAHGSKVPSHRLKRARRPAMQLKTRPPRQNIKRLSVDEAIPSKVAADQTSLTSLHEIETIPIREQAELHHNMKTKLAASIPSNPPKKGLALGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W6QJR6</accession>
    <name>W6QJR6_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g003615</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QJR6"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM29802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="37" mass="3572" checksum="EC2EEC69C428B755" modified="2014-04-16" version="1">MAGGKGKSIGGKGGKGDAAGKAQKSHSAKAGLQRYGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W6QKZ8</accession>
    <name>W6QKZ8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S06g000085</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792020">
        <property type="protein sequence ID" value="CDM37125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QKZ8"/>
    <dbReference type="OMA" id="WYNSPLE"/>
    <dbReference type="OrthoDB" id="4368526at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022190">
        <property type="entry name" value="DUF3716"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12511">
        <property type="entry name" value="DUF3716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="265"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="309"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM37125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="461" mass="50804" checksum="CE9B44313EAD834C" modified="2014-04-16" version="1">MGREIRFKRNSRGSIALQDSMLTNNLAQAIIKSSDSSPISSNPLQASESDSSDDDATDYPYQTNGEYGTDVATMTRKPAAQKEDPGPSVRARTAAELDATIKAQVEDPHYPGLDTAGLPMLRNFLTAAERKIRDLHPERTELDWKNSQPRPLISTLYRRAAQGQLCGLEAPADHKCTRCAHGKGQFMHCRIVFANTNAQWMWACASCVFFRRPYQYSFRPDVSPNVPAWVIAAVAEREPSNPLLCTYYSAKDIAIALELSKSTSRNLPAPVAHPNPEKIDDEYVPSEREPQQSPHAAVEVSIVHPPTHQPTIGSSRVRGSTVSNGTPATQDIDEEQPAKRRKSNVGPIRVSRGTTKDAPKRRKPEPGPAKPSGGATKDAPPKLKNGGLPFNTTWYNSPLEDPEVYRMKDKGHAIDTYNDLAAIIARATEDYSRMKAALLRKGFLPQSGDEESEEENVFSVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>W6QL86</accession>
    <name>W6QL86_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="13">CDR ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PROQFM164_S06g000181</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG792020">
        <property type="protein sequence ID" value="CDM37220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1365484.W6QL86"/>
    <dbReference type="OMA" id="FNIFAAC"/>
    <dbReference type="OrthoDB" id="245989at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03233">
        <property type="entry name" value="ABCG_PDR_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03232">
        <property type="entry name" value="ABCG_PDR_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000881">
        <property type="entry name" value="ABC multidrug transporter A-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000054">
        <property type="entry name" value="ABC multidrug transporter atrF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029481">
        <property type="entry name" value="ABC_trans_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034001">
        <property type="entry name" value="ABCG_PDR_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034003">
        <property type="entry name" value="ABCG_PDR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010929">
        <property type="entry name" value="PDR_CDR_ABC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19241">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14510">
        <property type="entry name" value="ABC_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06422">
        <property type="entry name" value="PDR_CDR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="484"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="518"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="594"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="626"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="732"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1156"/>
            <end position="1175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1187"/>
            <end position="1210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1231"/>
            <end position="1257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1277"/>
            <end position="1299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1311"/>
            <end position="1333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1427"/>
            <end position="1447"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="119"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="811"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="10"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="41"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDM37220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="1460" mass="164034" checksum="72E7ECF376719C3E" modified="2014-04-16" version="1">MSLGKFVANGDRETESVKDDVSSVEKREAEVHQLAREFTEQKTFSTTGENPFSAEPGSTLDPNGEHFHARAWCTAMLQMQTEDKQAHPLRTLGIAFSNLNVHGFGSDTDYQKSVGNVWLETFSLARKVTGRHQRKIEILQSLDGLVEAGEMLVVLGPPGSGCSTFLKTIAGETHGFFVDKNSKINFQGVSAKQMATEFRGEAIYTAEVDVHFPKLTVGDTLFFAARARAPRHIAGGATVNQYATHMRDVIMAIFGISHTKNTIVGNDFIRGISGGERKRVSIAEACLSMAPLQCWDNSTRGLDSANAVEFCKTLRMQTDINGATACVSLYQAPQAAYDHFDKVLVLYEGRQIYFGRTTAAKKYFLDMGFICPNRQTDADFLTSMTSHLERVVQPGYEYRVPRTPDEFAARWKASAERAQLVQDIEMYNANFALGGEYLDKFKQSRRAQQAKAQHVSSPYTLSYVQQVKLCLWRSFQRLKGDPSITVSSLIGNSIMALIIASIFYNLKADTNSFFQRGALLFFAVLMNAFGSGLEMLTLYAQRAIVEKHSRYALYHPSAEAFASMLMDLPYKVLNAITYNLVLYFMTNLRREPGAFFFFVFTSFVLTLTMSMFFRSIASLTRSLVQALAPAAILILGLAMYTGFTIPVHYMLGWARWIAYINPISYGFESLMINEFHNRDFICVNYVPSGSGYTDVGTHNRVCSTVGSVPGQPYVNGDDYIESAYGYTASHKWRNIGIIFAFMFALMVVYLIATEFITEKKSKGEILVFRRGHKALKKSKSEDDVEGGSSRSIAVKTQSDGIAIIERQTAIFQWKDVCYDIKIGKDHRRILDHVDGWVKPGTLTALMGVSGAGKTTLLDALATRTTMGVITGEILVDGKPRNNSFQRKTGYAQQQDLHLNTSTVREALTFSALLRQPAHVPRQEKVDYVTEVIKLLEMTEYADAVIGVPGEGLNVEQRKRLTIGVELAARPALLLFLDEPTSGLDSQTSWAILDLLDKLKKNGQAILCTIHQPSAMLFQRFDRLLFLQAGGRTVYYGDIGENSQILIDYFVRNGGPPCPPTANPAEWMLDVIGAAPGFHTDIDWYETWRKSPEYAHVQKHLTELKFERSQLVNPAHTVLGKREDKASYREFAAPFYEQLCEVQTRVFQQIWRSPTYIYSKTALCGSSALFVGFSLYNTPNTMQGLQNQMFAIFMLLTLFGQLIQQIMPHFVAQRSLYEVRERPSKAYSWKAFMISNIVVELPWNTLMSLIIFVCWYYPVGMYRNAEPTDSVTLRGAQMWLFIWTFLLFSSTFAHFMIAAFETAENAGNTGNMLFMLCLLFCGVLATPAQLPGFWNFMYRVSPFTYLVSGMLSVGISNTKVICATNEYLHFDPLNGTCGEYMEAYKSTMGGYVEHELATSNCNFCPISDTNVYLTSVSSNYSDVWRNFGIMWVFIVFNIFAACALYWWVRVPKVKKTATKTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W6QLS0</accession>
    <name>W6QLS0_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ankyrin repeat-containing domain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S06g000351</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792020">
        <property type="protein sequence ID" value="CDM37390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QLS0"/>
    <dbReference type="OMA" id="MHEFCAV"/>
    <dbReference type="OrthoDB" id="4267003at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="491"/>
            <end position="580"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM37390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="580" mass="65031" checksum="380DFDC6987285BF" modified="2014-04-16" version="1">MVGFDEEMLDSWGPAVWGVIFDRLQSGNVKGGTLQVAWPSNVDRKTAAQQIQWATKLPLAHLPQKALDIIFDKMVGFSVGVRYMEEKKIHAMHGLLKHNGPLKASVEKWFRRPGTVEKWRGLIRSYKSYEDAMGHLSDCTTFPRETDNHPFKTHPAYNAAMQCSSCLEFLVHFGIVTPNGYDLSGRSWIEAGLNSPNMDLLTYLVSNADPQHLIKPRDIRETHENHILLSLVGVGAFSQFVIALNRLRQAKLVPVDELRKIFHEAAMHEFCAVAPVAVAEALYQHGINIGNVEHQYHELGGQLESSWHIAAAFNPAGAEFMAWLEKFSMLNAEVRNSENMNPLMYAACFDEPASIDWLCQKCDPMQPRLTGGAQGYALICAARSSHLHSGEIFSIIISHLPDKLFTNEYGKIFGTEIAEGLASHKRKLADGRVRDPTQNVMELLAVRKMQALVRRLSNHWTRSQWHLALDAFIRDNDLGILRHSIGTGTRLLRSSSRDGSRNRRNVRYPESPQLSSISEHEVLPRENGNGSDPALADAIRRNRPSRVTARSGGRQTLGPIRDSSNMVTKNVGRMGSNRRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W6QLU4</accession>
    <name>W6QLU4_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Obg-like ATPase homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">OLA1</name>
        <name evidence="6" type="ORF">PROQFM164_S02g000686</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QLU4"/>
    <dbReference type="STRING" id="1365484.W6QLU4"/>
    <dbReference type="OMA" id="DFHDLCE"/>
    <dbReference type="OrthoDB" id="424823at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04867">
        <property type="entry name" value="TGS_YchF_OLA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01900">
        <property type="entry name" value="YchF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.300:FF:000001">
        <property type="entry name" value="Ribosome-binding ATPase YchF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000001">
        <property type="entry name" value="Ribosome-binding ATPase YchF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.300">
        <property type="entry name" value="TGS-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004396">
        <property type="entry name" value="ATPase_YchF/OLA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023192">
        <property type="entry name" value="TGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013029">
        <property type="entry name" value="YchF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041706">
        <property type="entry name" value="YchF_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00092">
        <property type="entry name" value="redox-regulated ATPase YchF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23305">
        <property type="entry name" value="OBG GTPASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23305:SF7">
        <property type="entry name" value="OBG-TYPE G DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06071">
        <property type="entry name" value="YchF-GTPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006641">
        <property type="entry name" value="CHP00092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="TGS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="4">
        <location>
            <begin position="24"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="TGS" evidence="5">
        <location>
            <begin position="309"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00068719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDM30537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="404" mass="45129" checksum="1A5E50A21FF116CF" modified="2014-04-16" version="1">MPPKKAVEAPTNNVVAFGRVKSNLKMGCVGLPNVGKSSLFNLMTEQNAAAENYPFCTIEPNEARCIVPDPRYDFLCKIWNPPSKYPAYLQVTDIAGLIKGASEGAGLGNAFLSHIQAVDGMYHIVRAFDNDEVLHVDDSVDPVRDLDTIQSELCKKDLDILAKAKIAEEAIVRKAGGKFKMLPLFDETTAKIKELLEQDKPVRDGEWTTPEIELINEKLRLITTKPVIYLINLTMKDYIRQKCKYLPKIAEWVKAHGGQGSDIIPFSVEFEEKLWSLKDDKPALDAFMADIKVQSRLGKITTEGFTKLGLQYYFTAGEKEIRCWPIKQGTLAPQAAGVIHGDFERGFIKAEVVAYQDFHDLCNGEKSMGPIKAAGKYRQEGKTYVVKDGDIVHFQFNVAPPKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W6QMW3</accession>
    <name>W6QMW3_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">Inositol-pentakisphosphate 2-kinase</fullName>
            <ecNumber evidence="4 10">2.7.1.158</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PROQFM164_S04g000390</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Has kinase activity and phosphorylates inositol-1,3,4,5,6-pentakisphosphate (Ins(1,3,4,5,6)P5) to produce 1,2,3,4,5,6-hexakisphosphate (InsP6), also known as phytate.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ATP = 1D-myo-inositol hexakisphosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20313"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57733"/>
            <dbReference type="ChEBI" id="CHEBI:58130"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.158"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="10">The EXKPK motif is conserved in inositol-pentakisphosphate 2-kinases of both family 1 and 2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the IPK1 type 1 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.158" evidence="4 10"/>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QMW3"/>
    <dbReference type="STRING" id="1365484.W6QMW3"/>
    <dbReference type="OMA" id="DCTMFIR"/>
    <dbReference type="OrthoDB" id="272370at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035299">
        <property type="term" value="F:inositol-1,3,4,5,6-pentakisphosphate 2-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032958">
        <property type="term" value="P:inositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.110">
        <property type="entry name" value="Inositol-pentakisphosphate 2-kinase, N-lobe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009286">
        <property type="entry name" value="Ins_P5_2-kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043001">
        <property type="entry name" value="IP5_2-K_N_lobe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14456">
        <property type="entry name" value="INOSITOL POLYPHOSPHATE KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14456:SF2">
        <property type="entry name" value="INOSITOL-PENTAKISPHOSPHATE 2-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06090">
        <property type="entry name" value="Ins_P5_2-kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDM35509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="348" mass="39105" checksum="39CD437F1134AB0F" modified="2014-04-16" version="1">MTKPNLLELPSGVRLVYLAEGGANVIYRFVGNPVLVKKDSKRPLSPPAFEDHCNLPAQLKGKLLRLRKETAADISYKEIARNFDTIIRPLFKPEELVDQTLIRLPEGLLSSCNSQLQIAELNGTRPKKRHGSYLCLHERFGLLITDMTTTEDPGASLAELKPKWLNQSPSAPTTAHRCRTCALREMKNRESQPLGLKEQRSFCPLDLVSEQYENVLRATGFIKGCTDRSRLAHILYRNPTLQRLQSLQKTERDVGLQGPAAQSREMSLAMTLRDCTMFIKIPHDEKSPVEIRLGDLDLKTGAGGKAGYWRDLETRLIDQGWYRGSNISQASGECALHSPRRPSQSYLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>W6QN92</accession>
    <name>W6QN92_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial thiamine pyrophosphate carrier 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PROQFM164_S02g001267</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mitochondrial transporter that mediates uptake of thiamine pyrophosphate (ThPP) into mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QN92"/>
    <dbReference type="STRING" id="1365484.W6QN92"/>
    <dbReference type="OMA" id="VISYAEW"/>
    <dbReference type="OrthoDB" id="270584at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000016">
        <property type="entry name" value="Solute carrier family 25 member 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24089">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0106">Calcium</keyword>
    <keyword evidence="13 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 14 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 15" id="KW-0813">Transport</keyword>
    <feature type="domain" description="EF-hand" evidence="16">
        <location>
            <begin position="78"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="16">
        <location>
            <begin position="114"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="268"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="388"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="491"/>
            <end position="580"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CDM31117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="584" mass="64177" checksum="422E09E7C48148AE" modified="2014-04-16" version="1">MASGESKDERDKRVAKLWETLDTRREGHIDLNGLKKGLKKIDHPLKNADDMVLRVAREVDTNGDGRIDQAEFRAFINRTEDGLWQMFQSIDRNKNGEIDKMELRNAFSRSGVTVSSAKLDRFFAEVDKNHDGVISYTEWRDFLLFLPLQSPTDLRAVLSYYTATGNLNPEGDVNINDLQGLGTNHPFLSSCIPAIQHVLYNFLSLPALAPFLPSAHAQTSQISKPEPVLEHEFVSLDADLDLEWLPLPQTTAMRMSFRYHGRKLTENTPQLGYFLAGGMAGAVSRTATAPLDRLKIYLIAQTSVKSTVQAAKDGSLLTAVGNDPRTLFGALKELWRAGGIRSLFAGNGLNVVKVMPESAIKFGAYESAKRAFAQLEGHNDPKRLRPTSQFMSGGFGGMVAQCFVYPLDTLKFRMQCETVKGGPKGNQLIAATARKVWNKNGLAGFFRGLPLGLVGMFPYAAIDLSTFEYLKRALIAKKARDCGCHEDDVPLGNFATGAIGAMSGGFSASIVYPLNVLRTRLQTQGTILHPPTYTGIGEVLSVTLKAEGPRGLYKGLTPNLLKVAPAMSISYVVYENAKRILGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W6QNP5</accession>
    <name>W6QNP5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S08g000086</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792022">
        <property type="protein sequence ID" value="CDM38035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QNP5"/>
    <dbReference type="STRING" id="1365484.W6QNP5"/>
    <dbReference type="OMA" id="LARMPFE"/>
    <dbReference type="OrthoDB" id="4364855at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004879735" evidence="3">
        <location>
            <begin position="21"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="329"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="90"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM38035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="388" mass="40618" checksum="3A42956095D186E1" modified="2014-04-16" version="1">MARFLRFLPFAMLGTGLDDADTSDSYRSEYAPSSVASAGQDVVFTTAPGSKNKNFADASSWADPAVTASSETSTVNDISSEASPTSVLDATSYTSSPSPSTSTTPSSTFPSSLTSTTTTTTISASATATASETTAVNSDSTTFSGGPSKTTKIAIAVPVSVIGLALILALLFFLSRRRRREKERNALPPPYDIAAGHRSAVSTQELMISPKSSTPEARRSLSNPAMSSAATSMPLPLPRIPIISISPSTESRGRTPSLGPSPDSSSVRRMPTAHGPGDSEAELGVAVAVSMAQRRSATEQDLRARVAPVVSSRGPSRLARMPFEDFSDDEVGIGIGIGGSDDDDDGAVSDVSDLDGRRRERDFDEVSVVSSFDEVSPIGEQERRFRGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W6QNP7</accession>
    <name>W6QNP7_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">intramembrane prenyl-peptidase Rce1</fullName>
            <ecNumber evidence="10">3.4.26.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PROQFM164_S06g000553</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>Hydrolyzes the peptide bond -P2-(S-farnesyl or geranylgeranyl)C-P1'-P2'-P3'-COOH where P1' and P2' are amino acids with aliphatic sidechains and P3' is any C-terminal residue.</text>
            <dbReference type="EC" id="3.4.26.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase U48 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.26.1" evidence="10"/>
    <dbReference type="EMBL" id="HG792020">
        <property type="protein sequence ID" value="CDM37591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QNP7"/>
    <dbReference type="STRING" id="1365484.W6QNP7"/>
    <dbReference type="OMA" id="HSFCNWC"/>
    <dbReference type="OrthoDB" id="271604at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039731">
        <property type="entry name" value="Rce1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003675">
        <property type="entry name" value="Rce1/LyrA-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13046:SF0">
        <property type="entry name" value="CAAX PRENYL PROTEASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13046">
        <property type="entry name" value="PROTEASE U48 CAAX PRENYL PROTEASE RCE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02517">
        <property type="entry name" value="Rce1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 13" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="27"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="228"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="302"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="CAAX prenyl protease 2/Lysostaphin resistance protein A-like" evidence="12">
        <location>
            <begin position="149"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDM37591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="337" mass="37484" checksum="4F7AF5421F36A0DF" modified="2014-04-16" version="1">MAPVGIMARLRSLYSKQDEPALSEHTVAFLSVLLTLLYVLPFYLSSTTRPSPNLSRDAPSVIRARIRAVTGSCIVSSVLVLWLIIEDNSSLGAGVRLLGWWPVGLLETLRSLFLTAVLFLGPLFERGIVEGEWKFWFRRSKLSESLGGWIGWRNYVAGPFTEEVMFRSAMVPLHLLAHTSPGRIVFLAPLYFGIAHVHHFYEFCLTHPDTPALAALLRSLFQFGYTTIFGWYATFVYLRTGSLLAVVLIHSFCNWCGLPRFWGRVQAGEYISPPITRGKEDSDDSIQVGVRGNSGLGVGWTVAYYVLLVAGALGFAQGLWPLTESYHALVSFSDKSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W6QNS0</accession>
    <name>W6QNS0_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S20g000005</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792034">
        <property type="protein sequence ID" value="CDM38578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QNS0"/>
    <dbReference type="OrthoDB" id="4371233at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM38578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="105" mass="12550" checksum="D83A987F0BD23C10" modified="2014-04-16" version="1">MYMWQMVFLSKLCVRSDGPLSSTVEEKVIPRKHWHTFKLRIKIVFLWHNSQKGSRPLKSSDKKLGSRDRHPLARLQRYYYTDETLETKSTRPANQTPRVNSDRCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W6QP27</accession>
    <name>W6QP27_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S02g001487</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QP27"/>
    <dbReference type="STRING" id="1365484.W6QP27"/>
    <dbReference type="OMA" id="GGWLFND"/>
    <dbReference type="OrthoDB" id="5330858at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018843">
        <property type="entry name" value="Utp8_b-prop"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10395">
        <property type="entry name" value="Utp8_b_propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Utp8 beta-propeller" evidence="1">
        <location>
            <begin position="8"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM31337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="928" mass="100557" checksum="F2497A7633FE0C2D" modified="2014-04-16" version="1">MDLQSPSVLAQLPRPLHASTGKTRVGDVFSLADAKKRKRYEVAVAVDGEAVNIYNVQTPKLVTSYAVPPQSTFSCRPCSVRRKLSKKSTVRRQTYTAVTKPEHQIKCFVEEIGSSGSSAPVISSSTTTVTDSTSPTTFVGIVPSSTDAEGETDPFDILAVHEDGRVRRLSSDLKTQRWSIQHSEIAKVCSTHNVQSSFLVEFDDAKKALFKRRQDLALLALGDLTTSGTNEPSILLLVSQPKNTDRVSLKDIIVQMFSVPAHAKSESGLDESQRLRHLQTFHIPDVSGLEATNGNAMQWSFHSGSAGLSLSFEKGFINVDLSQYSPCVTSQFVLEDEEFSSVMRISPQSVIGAQKSLVAVYDTQYHSVQRSIPAGDLLSSTGSTPEAPTNFISYFAKLGIAIATKGNTLIAFDLSSLPSAPSSSLKRTRDSLLIDAIGRGIGSSGAQWDISSKKHRSDNMASLRLTSPEQVEKWTQLTKTVEKATKTKNIDLFDNAVLTYFSTSDASTTLPVRGQYVNPEATLFLLSKIFAVEESATDDTMSASPSSQLRVAMWPPTTCDWLIRLGHLSLDNVEIALRRACKPRILQPFPTGSFIQALLDSDPSLKQVNQVLEGPTLISSDELAYALKAFLNQARSHSGTLEETARAITNGDLATPTQELSRQLGAETATLKDIFAGLNTSLQKIHSQPVSVVVHSLRSNLSRTELISMVHHLRLSLATGGYTSRFTENPPTPITLDQITPTLSLDVIIDLITASVDAVGPSGWISAVPAAGDFEDSVAAAASREMELIADMKSEVSAALAGVEEATYLKGVLCEYLRFADQVDTPATTSEDALAKMDSEAGPSHLVRYEKLNGADLLVFTRPGEGEDGYDGDAGGKMLPLSLKAASNDVSRTKIKKSTGEVKHRSSREIGYLRRKAVGKYSFERLII</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W6QPJ4</accession>
    <name>W6QPJ4_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PROQFM164_S04g000905</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM36024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QPJ4"/>
    <dbReference type="STRING" id="1365484.W6QPJ4"/>
    <dbReference type="OMA" id="WALPDCE"/>
    <dbReference type="OrthoDB" id="5979581at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050684">
        <property type="term" value="P:regulation of mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051334">
        <property type="entry name" value="SRPK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634:SF9">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="95"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDM36024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="476" mass="54120" checksum="278F7A09B0AA56F3" modified="2014-04-16" version="1">MDISSNNQHTMLRCSKIFARPLNLPITLASPRPSIPVFQSLWRRKLSSVSFAPGSTMAANHHAEYDWIEDVEQLEKYQPGGYHPIIVGDVLHDRYHIVDKLGFGGYSTVWLARDARLERYVALKVNISESIPREAKVLKALSAPPPSSSPVHPGYGLVPVLLDEFEVQGFNGKHTCYTVPPAQCNLRDAAFSRLFPLDVARALSYRVAQAVAYTHSQGYIHGDIHLSNILVKLPSSFDKLSIKQFYEKYGEPEMIPITRCDGAPLPPNVPATATLPLFLGKYAEKFVLSDAHPLLSDFGEAFSPASEIRLGQDCHTPAAFRAPEAKFELQIPLAYPSDIWSLATAIWEIMGIKSIFSAEYMHEDEVTAQQIDVLGPMPSEWWQRWEGRPQFFDDHGDPTESYKRNKWPPLEERFEICIQKWRRKFVGSEIEEDEKAAFLDLMRRMLSFRPEERPTAEEVLMSDWMVKWALPDCERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W6QPK0</accession>
    <name>W6QPK0_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Calycin-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S07g000270</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792021">
        <property type="protein sequence ID" value="CDM37921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QPK0"/>
    <dbReference type="OMA" id="WEMDSTH"/>
    <dbReference type="OrthoDB" id="425354at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053037">
        <property type="entry name" value="Pericyclase_pydY-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38115">
        <property type="entry name" value="LIPOCALIN-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38115:SF1">
        <property type="entry name" value="LIPOCALIN-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50814">
        <property type="entry name" value="Lipocalins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM37921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="220" mass="24410" checksum="C0393BC6416E6B37" modified="2014-04-16" version="1">MAAPADITMQNLNGKWEMDSTHSNPTDPILSLQGVGWLIRKTLSYATVTIYITQYADSENPALIHVDAQQVITGGIQGTKEERRLDWEEREHVDHIFGKLKGRSRQIAGTKSEDGAVRPVLEVQTKAGSPEADAKVLKFLIGETLIDGSKSEGFLAEEGEGVFLQSFVQNVESGWTAEQVWGFEIVDGERRHTRRVVVVKDGKVASARLVYAFKERKVAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2024-10-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>W6QRT9</accession>
    <name>W6QRT9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S02g002393</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QRT9"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM32242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="85" mass="9561" checksum="F9996BC1A009B083" modified="2014-04-16" version="1">MDLSNSDLGRIDTYLRTSEAGSCNSMHLMYRKHDSDRQSTYGVLRTPQIAITYLTSHLAHEASHQPAVICDPLVAISNCNYNRSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W6QRZ3</accession>
    <name>W6QRZ3_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S05g000697</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QRZ3"/>
    <dbReference type="OrthoDB" id="4360578at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM36864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="58" mass="7031" checksum="226E2B78E4528E2D" modified="2014-04-16" version="1">MLLADARFEDYNNDHLVLKKEIRNAILQEARPIFEQIVKEEQENRLESFLKDRRIFAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W6QSF4</accession>
    <name>W6QSF4_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein-L-isoaspartate O-methyltransferase</fullName>
            <ecNumber evidence="7">2.1.1.77</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PROQFM164_S02g002563</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>[protein]-L-isoaspartate + S-adenosyl-L-methionine = [protein]-L-isoaspartate alpha-methyl ester + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:12705"/>
            <dbReference type="Rhea" id="RHEA-COMP:12143"/>
            <dbReference type="Rhea" id="RHEA-COMP:12144"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90596"/>
            <dbReference type="ChEBI" id="CHEBI:90598"/>
            <dbReference type="EC" id="2.1.1.77"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.77" evidence="7"/>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QSF4"/>
    <dbReference type="STRING" id="1365484.W6QSF4"/>
    <dbReference type="OMA" id="HMHASAC"/>
    <dbReference type="OrthoDB" id="73890at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004719">
        <property type="term" value="F:protein-L-isoaspartate (D-aspartate) O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000259">
        <property type="entry name" value="Protein-L-isoaspartate O-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000682">
        <property type="entry name" value="PCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00080">
        <property type="entry name" value="pimt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11579">
        <property type="entry name" value="PROTEIN-L-ISOASPARTATE O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11579:SF0">
        <property type="entry name" value="PROTEIN-L-ISOASPARTATE(D-ASPARTATE) O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01135">
        <property type="entry name" value="PCMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01279">
        <property type="entry name" value="PCMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 7 8" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM32412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="237" mass="25564" checksum="D2C51FE32D555E0C" modified="2014-04-16" version="1">MAWYCSGSTNTELIENLFKAGLIQNERVKDAMIGVDRAHYAPSRPYSDSPQPIGYGATISAPHMHGHACEYLIDYLKPGARVLDVGSGSGYLTHVIANLVTSSSGNAQGQVIGIDHIPELTDMARSNMNKSKKGSAFQTNGTVKFITGDGRLGWKEGAPYDAIHVGAAADKLHPTLVDQLRAPGRLFIPVESEDSEGAIDPNGGQYIWVVDKKEDGSIHREKVFQVSYVPLTDAPRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W6QT64</accession>
    <name>W6QT64_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S02g002868</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QT64"/>
    <dbReference type="STRING" id="1365484.W6QT64"/>
    <dbReference type="OMA" id="QRFCYLP"/>
    <dbReference type="OrthoDB" id="4490227at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055560">
        <property type="entry name" value="DUF7136"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23584">
        <property type="entry name" value="DUF7136"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004879826" evidence="2">
        <location>
            <begin position="23"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="253"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7136" evidence="3">
        <location>
            <begin position="22"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM32717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="276" mass="30668" checksum="A942A71104B5F790" modified="2014-04-16" version="1">MPSSQASSWMLATCLGAIMVHASGMLETDLLFPRNKTYTPTEWFPVVFGVQNPELAPLVDLDISFMIRNANNMSDIVHWPTEIDWTNNTSKDPYFFYAYFSEFRTPGRWRVAWNVHWKSCNEFALFNTSMFPRAEMITNSTGWSTWFTIEEDGAPADIVTDTARDSCPDEFAVPITVTNHTIRVPAGEEWSNGRDCAVVDFSPTPTPTPSPNPCRIDVSEAVVESMEASWQARLCKSANPPDDCPVNENAAQGLVVVGLSCFLAVFGAVGFLLAPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W6QU26</accession>
    <name>W6QU26_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PROQFM164_S02g003188</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM33037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QU26"/>
    <dbReference type="STRING" id="1365484.W6QU26"/>
    <dbReference type="OMA" id="NQTMSSA"/>
    <dbReference type="OrthoDB" id="5589325at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018466">
        <property type="entry name" value="Kre9/Knh1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052982">
        <property type="entry name" value="SRP1/TIP1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40633">
        <property type="entry name" value="MATRIX PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G05410)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40633:SF6">
        <property type="entry name" value="MATRIX PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G05410)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10342">
        <property type="entry name" value="Kre9_KNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004882363" evidence="3">
        <location>
            <begin position="21"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal" evidence="4">
        <location>
            <begin position="31"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="113"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="128"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="206"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="239"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDM33037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="271" mass="27289" checksum="9BD29C7BAD409BB6" modified="2014-04-16" version="1">MYFSKGVIAVTASFVSLGLAADPLSFTSWPKEPLQPGKPVTLTWTGATPGQPVTILLRQGSSGDLQDVKPITTDGKGGTFTWTPDNDVKSGDTYAFQILQKDQTNYTALLKSAGKPAADIPEAKDTTETGTATSTAAATGTSTGATDTSTGTSGTTTGTENTTGTSTGTTAQTTDAPNTQTTGTTETTHGTHTTMTSTASKALINSAVNSSGSPSSSSHVSSTDKPMATSTEVVDGKKASSTGSVQTGAASIPQYSVQLVMGIAGLLACLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W6QUI8</accession>
    <name>W6QUI8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S02g003354</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM33202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QUI8"/>
    <dbReference type="OMA" id="AERAICK"/>
    <dbReference type="OrthoDB" id="4232400at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM33202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="60" mass="6691" checksum="41F8932AF031E3D7" modified="2014-04-16" version="1">MPSSDALQPPLTPAERAIVKSYGGWTRFMQSYGLKPWEDDDAEEGKKILEALALHEEASE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>W6QV38</accession>
    <name>W6QV38_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">1-phosphatidylinositol-3-phosphate 5-kinase</fullName>
            <ecNumber evidence="2">2.7.1.150</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Type III PIP kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PROQFM164_S03g000151</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13609"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57923"/>
            <dbReference type="ChEBI" id="CHEBI:58088"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.150"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.1.150" evidence="2"/>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1365484.W6QV38"/>
    <dbReference type="OMA" id="QSVWNDT"/>
    <dbReference type="OrthoDB" id="158357at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
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    <sequence length="2485" mass="277573" checksum="BFAED08E09B97B2E" modified="2014-04-16" version="1">MDSQHSQDSQSPSASSNSLPLERRGSRSSMATTQTERESMNAALDNYHNAAYQSESLTLFNDFTSPPAPAAISDEKRLSDELQGGLSGLYSRFRTSVGGVRDIVSGGGKTADKNPTETPAVKSLVSENSLANPVSDVATSSADYLPSQPNSSQGSRLHSPVVPDFHTYQEPVQQANIGKRSRISSKNGSISSKASVSPSLGIKPSIAPLTKATGSAIVADPAVTQLHVNVVGKADCSRSSSINGPFQGIHNAGSTSIGSKEGSMDLPMSQTSSSLSQNLSNSPVLSAKMHESHHEEFNLTDSATYTPDNQSRKSVSTLDQQKLPEHSSQSANMRDTKQSEPVQDHASQHPAERSKSRASFPSEEPKASVSTSNSLSKLSSHDSVPYNAEKLPTNMETTIPRDSSNSNEPAKVTAPGRSNEESTPSIRAARLPGYVISRASTAETTTTVSSLPPLKTDFDRATSQARRQPPAGGDGVLSQLRSKLLSRDFWMRDENAKDCFHCGEPFTTFRRKHHCRTCGQIFDSKCTLLISGTRFGQPGNIRVCKPCEKMINAHDDDSSEFSDSEQSPIVANPRVSELTWTSPGRASADDDDSSSVVSQSIDHVLRTPTMAIPATRRAGEGHNRRSAILEIDSDRPLTRPTSSRSLRSSLGGRPHSLSHKRHHSRQQYIRGFKPYHEDRAPFQRRHADDIDAESRLPAFHKDNIIDPDLAQYLSDDASSGDEQPSLLSAVSEGTLSKSGGENEKASFGGLLAAMKKGRSAFGDRSTPSTNRDADEASITSSRAVNLPRFSRRRNLSVTSSYQPRHSPRTSKDNMPPHDNSAPVISLPENVKQGGFKMTRSSSMRGIDAPPVELNKASLEHVRKLLHQLLVESAVPNCDSWENALMPILLKAADEVDPDVQKGDDMDIRHYVKLKKIPGGRPGDTSYVSGLVFTKNLALKGMSRNISRPNILIITFPLEYARQQQHFMSLEPVIRQEREFLENLVSRIAALRPNLLLVEKTVSGLALGLLEQAGIATAYNVKPSVLEAVSRCTQTRIMTSMDKLLTTTLHSECSSFDVKTYVHNGRKKTYMYISGCPKELGCTIILRGGDDQVLGNVKSITEFMVYVVYNLRLETNLMRDEFGRISTSPTEESAVGHDKDNKFNPQITTHEGNAHLVDLSNAQQGANEKRGDISDSQILVDADAAKVPDNIPMPTYYNDMVKDYETKILSASPFVKFEAPYLLTRAREMERRLSYLKSLRDQDRNSNQITDEKVKPQKFVLITPEMVHQSPQDAPAKVKEVLHAAHEAEYDRALYHHQTQKRQWEAYVAGNSNMFDPYAHQNLVILYSVVCTTTSVPCSGPDTFALEFYNEHGDDTIFESDLTIGQYVEDLCHTANSVCTVNGCEKRMFEHHRQYVHGEAQISVLVQPYPSKLRGLHNAVLMWSCCKICGNETQVMPMSPSTWKYSFGKYLELCFWGRHLLARTGGCSHDLRRDYLHYFGYRDLALRVQYDPIRLLEIIVPRPRVTWKVDNDLRLRNEVYLRTEQRLNKFMISVQDRLKGINAESVVPELLESCKTKIETLIKKSHEDHSSLVRHLQDKYTSSRYWEIIPLNEVLRAVQEKVVEWDTIFADFEMNFFPSEKDIKHMATLQLKKIFLDKDATSVSTDDALETPTDVEDENDQEDDRPRMMRRMTLSPEKAQDVLVSVVEEHTGKKHREDLEEVELHSPPASAEEATLSVDAIGGTRSSPQDEAVSQEVRHLDLAVPVGHASISNQSPINTDLPVMISGDGSSELSPPESSRIPDQGTKNGTEDSVSPDIANTPVRRPSAIPRPTELAFRRTGKIRSPPLLRTQSQPAANLPRSSHSIQLPGLKLAFANPSDPETPAVQSPTKSSDRKLSDRLGLSSLKSARFAAGQSLIPRSRGISQVSHLARHFEQLSREFEKERQRERRQRTAKGTQSRAFPLASSKPIVEVYRNVREAVEEREPPVDSDEYLPSAPRIPMDDMSRKSDELTHDHKTHNEPSLASESPAEPMKVDSALCPDDELLSGDEADDHQSDEDQNIVEDLHPVDSHEETKQSPEDDSIDFKELPKHERTTLLKMLTNFWSERSASGWASLDYPLSVMDHVFADCNIIVREDEPSSLVAFALDSSDYKEKLSTIQQRFDETEEQKPDAGDDIEAAKEAQVEHALLRPTGTHLKYQFQEGQAKMLCKVFYAEQFDALRKKCGVADRIVESLSRCAKWDSKGGKTKSLFLKTLDDRFILKSLSTIETQAFLKFAPAYFQIMSEALFHELPSAIAKMFGFYQVIIKNPVTGTEFNWFLLLMENLFYDRVPTRIFDLKGSMRNRKVESTGERDEVLLDENMVDFIYETPLFAREHSKKLLGQSVWNDTLFLGRQDVMDYSLMIAIDESRNELVVGIIDCIRTYTWDKKLESWIKDKGFAGGGRNRPTVTSPREYKGRFREAMARYVLQAPSCWHQFPSNAMYRYENQNTEVETVDGNGFVEDTGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>W6QW48</accession>
    <name>W6QW48_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">3-isopropylmalate dehydrogenase</fullName>
            <ecNumber evidence="4 14">1.1.1.85</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">leu2A</name>
        <name evidence="16" type="ORF">PROQFM164_S11g000047</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>(2R,3S)-3-isopropylmalate + NAD(+) = 4-methyl-2-oxopentanoate + CO2 + NADH</text>
            <dbReference type="Rhea" id="RHEA:32271"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17865"/>
            <dbReference type="ChEBI" id="CHEBI:35121"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.85"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="14">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="14">Binds 1 Mg(2+) or Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="14">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 14">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.85" evidence="4 14"/>
    <dbReference type="EMBL" id="HG792025">
        <property type="protein sequence ID" value="CDM38344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QW48"/>
    <dbReference type="STRING" id="1365484.W6QW48"/>
    <dbReference type="OMA" id="LWRETVQ"/>
    <dbReference type="OrthoDB" id="419183at2759"/>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00072"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003862">
        <property type="term" value="F:3-isopropylmalate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:L-leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.718.10:FF:000006">
        <property type="entry name" value="3-isopropylmalate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004429">
        <property type="entry name" value="Isopropylmalate_DH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00169">
        <property type="entry name" value="leuB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42979">
        <property type="entry name" value="3-ISOPROPYLMALATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42979:SF1">
        <property type="entry name" value="3-ISOPROPYLMALATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="12 14" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="5 14" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="7 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 14" id="KW-0520">NAD</keyword>
    <keyword evidence="9 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="15">
        <location>
            <begin position="5"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CDM38344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="364" mass="38748" checksum="D08A6F3029B9FF0E" modified="2014-04-16" version="1">MASYNIVVFGGDHCGPEVTAEGVKILRVIEKSRGLTFNLQEHLLGGASIDATGSPLTDEALNAAKNADAVLLGAIGGPKWGTGAVRPEQGILRLRKEMGTFGNLRPCNFAAPSLVDSSPLKADVCRGVDFNIIRELTGGIYFGERTEDDGSGYAMDTEPYSRHEIERIIRLAATLALQHNPPLPVWSLDKANVLATSRLWRKVVTEIMEKEYPQLTIGHHLIDSAAMLMIKDPRKLNGIVVTSNLFGDIISDEASVIPGSLGLLPSASLSGIPDGKSRVNGIYEPIHGSAPDIAGKGIVNPIATILSVAMMMQYSFNMIDVARVIEQAVSNVIEAGVRTGDIGGTAKTTEVGDAVAAELEKLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>W6QX87</accession>
    <name>W6QX87_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Sugar transporter STL1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">STL1</name>
        <name evidence="11" type="ORF">PROQFM164_S03g000891</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QX87"/>
    <dbReference type="STRING" id="1365484.W6QX87"/>
    <dbReference type="OMA" id="TQHFQRM"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015793">
        <property type="term" value="P:glycerol transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000061">
        <property type="entry name" value="MFS sugar transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF55">
        <property type="entry name" value="SUGAR TRANSPORTER STL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="92"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="184"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="314"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="341"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="374"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="436"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="17"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="517"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDM34167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="539" mass="59471" checksum="CBE20CAA613C36BD" modified="2014-04-16" version="1">MWTTTSGLRGKKLHLAITFTSVVGFSLFGYDQGLMSGIISGDQFTKEFPPLHGDSEHVAVLRGAVTACYELGCFFGAIFTMMYGQRIGRTPLLVAGGILMIIGTVISTAAFGPHWGLGQFVIGRVISGLGNGMDTATIPVWQSECSRAHNRGFLVCFEGAIIAVGTFIAYWIDFGLSYVDSSVQWRFPVAFQILFAALVTGGALMLPESPRWFVMQGHDEEALRVLAQLNDSAVDADDVLADFNMMKADLKAMESLEASSWRVLFTGGKTQHFQRMAIGCSGQFFQQFTGCNAAIYYSTLLFEQNLHMEGKLPLVLGGVFATVYALATIPSFFMIEKVGRRNLFLIGFLGQGLSFMITMGCLVRSNSQNAKGAIVGIFLFICFFAFTTLPLPWIYPPEINPLRTRTKAASASTCMNWITNFAVVMFTPVFSNQSDWGIYLFFALINFIAIPFAWFFYCETAGRDLEEVDIIFAKAHVEGKWPYRVAQEMPKLTIAQITQFQNELGLDTSDLQVNTEAEKAETAMSSSSEAKNGDTKHEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>W6R4S8</accession>
    <name>W6R4S8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="11">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PROQFM164_S05g000655</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6R4S8"/>
    <dbReference type="STRING" id="1365484.W6R4S8"/>
    <dbReference type="OMA" id="MPSEMFP"/>
    <dbReference type="OrthoDB" id="8120565at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000026">
        <property type="entry name" value="MFS quinate transporter QutD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF14">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="104"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="195"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="224"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="334"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="375"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="400"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="435"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="477"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="502"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="61"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDM36822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="566" mass="63002" checksum="E9B7A35BDFE76B54" modified="2014-04-16" version="1">MSKDTKHPSDSIDTSPVDDFPERNTTLGDLEHMLRDQQYFSQSYGRPGIKSFVKSPVVVLCSWAAAVCGFLYGYDQGLINVTLIIDDFLNSFPEVNPEQSPRAAFYKGLVAAIFELGAVVGALQSAIFCDRISRRYTIIVAVFWYLVGSALQAGAVNYTMLVFGRLIGGVGVGRASMIAPLYISEIAPPHIRGALYTLQQWMLILGIVSAYYTTYGARHISGHWSWRTAFVAQMLPGTVLLGIVLVLPFSPRWLGIKGRDQECLETLSKLRCLPESDARIQAEWINIRCDILLQQRLNGRWREHSTGGSSFWQQCKVEGRKWGNCVSSRYIKRIYIGIVLNAFQQWVGVNGFTYYSTTLFAQLGYDYEQRLTLSGLLSIVQLIGSTVPVFIIDRIGRRPLLLFGTFMLMSCHIINSVIVGISYTDWPGHQASAKAGTAFMFLFMFFFETSWGPIAWGLPSEILPSIVRAEGMALSTASNWLSNFVVGLIVPSLVAAAPYGSFALFSCTSLCALIWVFFFVPETKGTSLEGLSLLFKDNVYEEEAAQRNELISELIRTHAPLGQSEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W6R692</accession>
    <name>W6R692_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="10">DNA repair protein Rad4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PROQFM164_S06g000278</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the XPC family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792020">
        <property type="protein sequence ID" value="CDM37317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6R692"/>
    <dbReference type="STRING" id="1365484.W6R692"/>
    <dbReference type="OMA" id="TWPGKTK"/>
    <dbReference type="OrthoDB" id="300780at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000111">
        <property type="term" value="C:nucleotide-excision repair factor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071942">
        <property type="term" value="C:XPC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2460:FF:000001">
        <property type="entry name" value="DNA repair protein Rad4 family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.20.110">
        <property type="entry name" value="Rad4, beta-hairpin domain BHD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2460">
        <property type="entry name" value="Rad4, beta-hairpin domain BHD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.260.10">
        <property type="entry name" value="Transglutaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018327">
        <property type="entry name" value="BHD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004583">
        <property type="entry name" value="DNA_repair_Rad4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018325">
        <property type="entry name" value="Rad4/PNGase_transGLS-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018326">
        <property type="entry name" value="Rad4_beta-hairpin_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018328">
        <property type="entry name" value="Rad4_beta-hairpin_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042488">
        <property type="entry name" value="Rad4_BHD3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036985">
        <property type="entry name" value="Transglutaminase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12135:SF2">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12135">
        <property type="entry name" value="DNA REPAIR PROTEIN XP-C / RAD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10403">
        <property type="entry name" value="BHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10404">
        <property type="entry name" value="BHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10405">
        <property type="entry name" value="BHD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03835">
        <property type="entry name" value="Rad4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01030">
        <property type="entry name" value="BHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01031">
        <property type="entry name" value="BHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01032">
        <property type="entry name" value="BHD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rad4 beta-hairpin" evidence="7">
        <location>
            <begin position="525"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="domain" description="Rad4 beta-hairpin" evidence="8">
        <location>
            <begin position="585"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="domain" description="Rad4 beta-hairpin" evidence="9">
        <location>
            <begin position="655"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="184"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="336"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="504"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="770"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="72"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="197"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="207"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="350"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="504"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="770"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="861"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="880"/>
            <end position="892"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDM37317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="905" mass="101741" checksum="2E2FC89B8C6D37D1" modified="2014-04-16" version="1">MPPFLLRKRVSSEDPPPAKRQARPDNSQAPPQAPQAPQAPQAPFHLSDSDSDSNSLSDAPEGLLKENASASEESEDEEEDIDWEDAIDTKTSVTRPVAAPELQDLELTLDQNETHVSDLLEGKKGPSKIERQIRIQTHCMHVQCLLFHNAIRNSWSNDSKVHEILRKKLPEGIQKEVKKWRIASGLELPEPKPEPKSKKKGKKAKKNKDWSDESERLEPGQPDMSRGDPIIILMKVLVAYWRKQFRITAPGLRKYGYRPVSALETAITDFREEEHDPERHGERIANLDEFRATAERMQGSRDVGAQLFTALVRALGIEARLVASLQPLGFGWTKGETYTPLTPSKADKDPGDEEESEGSEPETDAENKVPAKKRKQIDADLPFPIYWTEVASPVTNEIISVDPLVLSNPVAPFADTDLQANFEPRGAKADRAKQVICYVVAHSSDGTAKEVTTRYLRRRTWPGKTKGFRMPLEKVPVGQRGHYIAFDWFGMVMRGYQRARKSKTAVDKLEETRDLQPNQPEKKKTAQTADTLQSLRTSTEFVLERFLRREEALRPGAEPVRTFIAGKGVRAKEEPVFRRADVLKCLSAESWHKEGRKPRPGAVALKRVPIRAVTLIRKREVDELHRQTGEKPLQGLYARDQTEYIIPPPIQDGRIPKNEYGNIDCFVPSMVPEGAAHVPLPGTVRVCKKLGIDYAEAVTGFEFGSKMAVPVIQGVVVAAENEGLLRDAWKVEAEEKRKREELKAEKKILQTWRKFLFGLRIMERVRDEYGGGDPDADRERDSHNPFAVEKKKREEESEDDGDQEMPDRESSYNAIDHGGGFLLPGHEDAADDGLIVEHHDQQQSPAGPSHTDYDPDDNEPFESGPPSESPPVSISSGSDNEVDNNGEEEAEPEYVPRSTRRTRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W6R994</accession>
    <name>W6R994_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Probable transposable element</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S12g000036</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792026">
        <property type="protein sequence ID" value="CDM38427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6R994"/>
    <dbReference type="STRING" id="1365484.W6R994"/>
    <dbReference type="OMA" id="IDIRFRS"/>
    <dbReference type="OrthoDB" id="4324149at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14529">
        <property type="entry name" value="Exo_endo_phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE-1" evidence="1">
        <location>
            <begin position="216"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="2">
        <location>
            <begin position="585"/>
            <end position="664"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM38427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="826" mass="95094" checksum="EF28641208D3B28F" modified="2014-04-16" version="1">MPISSEKEEILLSDAVDAYKLGQFKSIQAAASHFGISKWKLRNRSNGTPSKKGRTATNKALNQSQERSLIRCIELLNSVYTPPTALDIEGAANRILQHCGSDRQVSKMYGYQFIARLPPYITLRTQKPMEKARIEAELHGELVHWYKVFGQFLKKNKIQAHELYNWDETGFQLGVGTKENVASTRENETIATGGIGQNITDWFDGDNDPSNYRVIKPTAKGWTDDKTAIQWLLDFHYTTKKRVTKGRPRVLVMDNHGSHGTPEFEYLCQSLNIIPWWFIPKLTHRCQPLDGKPFSVLKQKFRKKNNEIVRWGGDVDDKRHFLRLIKTVRKDTFKSRTIKSSFYDTDEPVLEIYGHTPSPEAEIPSSVTNSPPNSDQRFSKIENKLQTIFENDEPDLPKVQKHINRAIRGGKQAIQDLALAKQTIKKMQSHKIPVKKSKRVIKGASKSPLSSIAGNSRVHRRCTKETKLDIGNESAHARIRDYWLRANQALKEKEEASGGRDYLDVDDEFFKYVNIDIRFRSLIYVNRRISTSSHLQIPCNHPDVVAIKIWTAASQTLFFSVYIPPVPLFTVDDASAMPVLTAIADPMWGNNYIAPRFIEDASDLIDFFQAHNLHSCLPRGTATYWAFNNSRQNSTIDQTVTDNPDLLIKCYLYHENYGSDHRATYPEWNLQLRSRPNTKARKAYERADWTRIGEEVVRQMNPWKQIKTRPTLDRVVENLTAVTAQAVDRFTPDTRPTPYSKRWFTPDLKTQQVEVNQLRRRWQANCAELGREHANTTAAFEAMQQKRRAWTRTIEKAKSSHWKQFLDEAGKGKLWKAATYMKPRET</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2024-10-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>W6PQ37</accession>
    <name>W6PQ37_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S01g000097</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PQ37"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM26288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="38" mass="4132" checksum="222C10BD01F960EE" modified="2014-04-16" version="1">MHERPGALKLAAKQINFGLNSAQLSVKQTRIDLNVPDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W6PQJ3</accession>
    <name>W6PQJ3_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g000267</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PQJ3"/>
    <dbReference type="STRING" id="1365484.W6PQJ3"/>
    <dbReference type="OMA" id="GSFGAHI"/>
    <dbReference type="OrthoDB" id="4106209at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM26458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="297" mass="33165" checksum="88099CAB29CE235B" modified="2014-04-16" version="1">MRKPSVGQIVYNATFPRPRPNDPGSFGAHITRNLVPEVRVETSLFYGSLDCIEAQYPGLDYSYGPHRMRLGRFPWHRKLFQTFDQLDLTEEEISNLCRWEGTKSARQRYEAEEGITVQDTTAHSVRPASPQPAPSIEIHFIDCDFCGTEEEDDQIIETQSNDTVRAIDSRASSYRSAEEHEIEEELSDEEMESCGVALNNRILAAMAARDQGTDVPLDEDWEQWLKEAGERGSFGEMVHAIRANQPLTLVADNVRIPRGRGAARVVTRAALFTVPDSIIATNTALPSTSNHASGTAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W6PR27</accession>
    <name>W6PR27_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acyl-CoA N-acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g000124</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PR27"/>
    <dbReference type="STRING" id="1365484.W6PR27"/>
    <dbReference type="OMA" id="QYYYVFS"/>
    <dbReference type="OrthoDB" id="410198at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052523">
        <property type="entry name" value="Trichothecene_AcTrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791">
        <property type="entry name" value="GNAT FAMILY ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791:SF1">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13673">
        <property type="entry name" value="Acetyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="126"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM26315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="231" mass="25228" checksum="2313E64AABDF4995" modified="2014-04-16" version="1">MAVASVPITHGGDSMLDSVAALNGRVFDTDPVITYMLLDMSQQKRLAYLPTYWTALIKSALLNRAVITEADGWKAASVMIPPGGYVDNAWTLLCAGFLGVLWKIGLPGVKRLWFEFSGMTDNAKRLGLRGQSQYYYVFSLGTEHEHRGKGLAKAIMRDHQQAAQAANLPIWLEATSTGSRALYLSMGFEEIEEIRLGKGKVAADASPQPDGPGVSLWAMVWWPTPTPEATP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W6PRJ0</accession>
    <name>W6PRJ0_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S01g000607</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PRJ0"/>
    <dbReference type="STRING" id="1365484.W6PRJ0"/>
    <dbReference type="OMA" id="TVGWWAM"/>
    <dbReference type="OrthoDB" id="405906at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056120">
        <property type="entry name" value="DUF7703"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37013:SF3">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_1G05950)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37013">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_1G05950)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24802">
        <property type="entry name" value="DUF7703"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="26"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="57"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="86"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="129"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="167"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="204"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7703" evidence="3">
        <location>
            <begin position="27"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="290"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="290"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM26798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="313" mass="34976" checksum="DA93E1BE7052717D" modified="2014-04-16" version="1">MSSLSNSSPGNWITGSYTGDSIGVRITIATFISVAWYNVIELVVLIFLTFKRYEGAYFWSMLIASVGILPYSVGYLLKFFNLTSATWVPVTLLTVGWWAMVTGQSFVLYSRLHLVIQNMRVLRMVKTMIITNIFLLHVPTTVLTYAANFSSSAASVAGYDVMEKLQLTGFCVQEVIISGLYMWETNRMLRLNQDHISRKTILQLLAVNVSCILMDIALMIIEFRNFYIYQTTLKATLYSIKLKLEIAVLGKLVNIAHQHMWRPSSFNAAGGQYPSFVDPCHALHDFSHADSSATSSASKGRASGTEAIDSDVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W6PRS3</accession>
    <name>W6PRS3_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DUF726 domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PROQFM164_S01g000379</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMCO4 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PRS3"/>
    <dbReference type="OMA" id="KEVGWEV"/>
    <dbReference type="OrthoDB" id="277931at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007941">
        <property type="entry name" value="DUF726"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17920:SF3">
        <property type="entry name" value="TRANSMEMBRANE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17920">
        <property type="entry name" value="TRANSMEMBRANE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 4 TMCO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05277">
        <property type="entry name" value="DUF726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="531"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="574"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="385"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="977"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="93"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="143"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="160"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="425"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1007"/>
            <end position="1020"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM26570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1103" mass="120708" checksum="6610FDD9DF14D52B" modified="2014-04-16" version="1">MTAASGVTVDTSDYPILSPPNALHSSQHEPQSTKGGSPTNQNGKETERSAPQPVAPKPAAGSVKQDPIASDEVDDFGLPIRARRHNPAPSEGENASQNIQNVPVSSTGYSDAVEKGKEPELSQGKLANSNNTEERGQGADHNTSSTLPSYSSASTALAQPRTSASKQRSPQVSEWSHQRLAQPDAHYPESEESEPEPDEWKAMPALGEFDYYDDYGRLIARGAKEESDEAVYQGLGGAGRGYTRVQLDDDAQSATSLDDDTSYLFREAGGNSAGLVGEELRDTISQLQATKDLLNETQKIAYVGVVRLTIHYMNHDLASIATTKSTRRTMQKASDAMRKWGQAIMGRVYAHMDINSAEQIMIEQLAEHGVEPEDLVRPLMQNARVKNPMAESEPKTSTSSRKFDSPSRLSAETDSSELDPPPPYEVHETEELPEVKTPSEMPTSERIDIDLRWTVLCDLFLVLIANSAYDARSRTLLERVGAALSVTWLQISRFEKRVTDSLEMQEQEEKENWDESDHMEKRRKMALKRKYMIMGLATVGGGLVIGLSAGLLAPVIGAGLAAGFTTVGITGTSAFLGGAGGTALIASGATIGGSTIGMRASQRRMGAVQTFEYRPLHNNKKVNLIVTVSGWMTGKVDDVRLPFSTVDPIMGDIYSVLWEPEMLRSMGDTINILATEALTQGLQQVLGSTVLMALMASLQLPLVLTKLAYLIDNPWIVSLARANSAGLVMADSLRERNLGNRPITLLGFSLGARVIFSCLKELAEKGAHGLIQNVYLFGSPVVANKDEYLKARSVVSGRFVNGYATNDWILGYLFRATSGGIMKVAGLAAVEGIPGIENFDITSLVNGHMDYRTAMPRILREVGWEVLEDEFAEIEDPDPDNHAERQRELIREIDEARREAEAKPEKKRFGLFKRGKMAEKKKWETYDVDKNTAPRESSDPESSPGTVLFDIEAIRAELLSEAIEVKELESTMPLMKLDLNAPSKPSPAQPSSPIDRRPKTPELPAVTRTSSLPPQASGQYSPYGPNEFSPAPMHEDMEMTFDTSFYESPRFRNDDLHSRPELRTASTMPTVGASAIGAMAMEPNAWADHDQGHRDGEISMTFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W6PRU6</accession>
    <name>W6PRU6_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Dihydrodipicolinate synthetase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PROQFM164_S01g000404</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the DapA family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PRU6"/>
    <dbReference type="STRING" id="1365484.W6PRU6"/>
    <dbReference type="OMA" id="ADYSIVI"/>
    <dbReference type="OrthoDB" id="191315at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008840">
        <property type="term" value="F:4-hydroxy-tetrahydrodipicolinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00408">
        <property type="entry name" value="DHDPS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128:SF66">
        <property type="entry name" value="4-HYDROXY-2-OXOGLUTARATE ALDOLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128">
        <property type="entry name" value="DIHYDRODIPICOLINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001365">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00146">
        <property type="entry name" value="DHPICSNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="3">
        <location>
            <position position="133"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="3">
        <location>
            <position position="163"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR001365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001365-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR001365-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDM26595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="312" mass="32926" checksum="78EF23912D9620EA" modified="2014-04-16" version="1">MRPLPTGIYTPLPCFFGDDEEIVIASAGTIPVISGSMGEAIHLSHEEKKQLIRSARVALDEINLTGVPIVAGAGGASTRESIQLCKDAADAGADYVMVIPPGYYAGALLADSTSIKNFFVDIAEASPLPVIIYNFPAVSGGIDMDSDLIVQIIKSSANICGVKLTCANVGKLTRIMAQVSSLDFQKDFPRSSSTPFRAIDGFIDFLLPSISVGSAGAISGLPNIAPKSCVKLWDLCQDSGSSKEATELQNLIALADGVALKIGIAGMKKLLHRQFGYGDKPRLPLLPMDDKVADTILSSPYLKALLDLEATL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W6PS05</accession>
    <name>W6PS05_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Actin cross-linking</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PROQFM164_S01g000345</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FRG1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PS05"/>
    <dbReference type="STRING" id="1365484.W6PS05"/>
    <dbReference type="OMA" id="ACDVNGK"/>
    <dbReference type="OrthoDB" id="5539371at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23339">
        <property type="entry name" value="beta-trefoil_FSCN_fungal_FRG1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008999">
        <property type="entry name" value="Actin-crosslinking"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010414">
        <property type="entry name" value="FRG1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12928">
        <property type="entry name" value="FRG1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12928:SF0">
        <property type="entry name" value="FSHD REGION GENE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06229">
        <property type="entry name" value="FRG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50405">
        <property type="entry name" value="Actin-crosslinking proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDM26536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="259" mass="28435" checksum="3300D9D60585B9C5" modified="2014-04-16" version="1">MVKPLTFKGDKPKKRKTRTADTEAPTPKSRKTEPEPDDNPEDQSWVSADSPSDIAGPVVLVLPSDDPTCVASDANGQVFASKLENLIERDPSTAEPHDVRQVWVASRVAGTESFSFKGHHGKYLSSDTHGLFSATASAVSHYESFLVIPSPEVSGTFSLQTHGGDGESFLSIKENAKAASGVEIRGDANTISFETTVRVRMQARFKPKLRASKESKAYEKISKKELEGIVGRVLDDEEVRRLRKGRRDGNFHEILLDVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W6PS15</accession>
    <name>W6PS15_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major facilitator superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PROQFM164_S01g000817</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PS15"/>
    <dbReference type="STRING" id="1365484.W6PS15"/>
    <dbReference type="OMA" id="QYQWLGS"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17327">
        <property type="entry name" value="MFS_FEN2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000064">
        <property type="entry name" value="MFS allantoate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF1">
        <property type="entry name" value="ALLANTOATE PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="162"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="196"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="295"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="337"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="369"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="394"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="426"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="454"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="70"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM27008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="518" mass="57563" checksum="7BCCD741EC414907" modified="2014-04-16" version="1">MASEEKAIGISSSVDTGMDMGNIKHVDPTIEKHAHDADEAMKALGNLHGETIELDEATNRRLLKIIDWHMMPIMCFIYGMNYLDKTTLSYASVMGLKKDLNLEGDQYQWLGSLFYFGYLAWEYPTNRLLQRLPLGKYSAACILIWGMILSCFAAVNNYSGAIAIRFMLGVFEAAVTPGFALLTSQWYTKKEQGSRVNIWFSFNGVGQILGGVIAYGIAVGAEKHGSAIEPWKIIFLVTGLLTICLGLVFLWIVPDNQLNARWLNEEDRILAVARVRVNQQGIGNKHFKLYQVKEALLDPMTWAFFFYALIADIPNGGISNFFSQLITSFGYNAKESLILGVPGGAVEIVALLINGYVGQITGQRILASLGGLVAAIVGMLLIVALPLSNNVGRLIGYYLTQASPTPFVALLSLISSNVAGYTKKTTVAALYLIGYCVGNIIGPQTFRPKDAPRYVPAEVTIIVCWGVCLFLLVGVWMWYRRENQKKILFIAHPEYVRLENQEFLDLTDRENPEFLYSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W6PS29</accession>
    <name>W6PS29_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S01g000484</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PS29"/>
    <dbReference type="STRING" id="1365484.W6PS29"/>
    <dbReference type="OMA" id="VYLWWKE"/>
    <dbReference type="OrthoDB" id="4358152at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM26675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="487" mass="55621" checksum="B5C496F94D524052" modified="2014-04-16" version="1">MTSNLQHANSTLPDEIQHIRSPATRDDRCDDCPPSLSVGSKLCSSFSLRCSLDPNPETKDPFGRLPWFGLEELLLHLPDLPTLHQLCQASPAVSDYLNHKIGFFPKLVERIIDQWDHERGLSEDTRVFFRTLVYLWWKEESVASGIPSDDNPLPVSFHDELVYSINIAREGFSEPIKVGCIRLPHSTPPKILRYLLSLTSRIRGDAHAFFHDAMTLCLSADIQKLENRKSPWPKNGTRPPGIPVHIGTREGGYPPTWLEEQRLMQAFLKPYIFSVLRRIVCEKRLLNTNSPPPGTKFPHTLMYLQGNLLIDFWRTFACYGWMRTEPIEQLETVLSWMHENKSRKRAANFTICCPKFTSLSDCQRSRGLDNLQHIHLPGCFFAQNCSAVPQSGVKIAGFRGEFQRFGVSFWDNERMLWLGLALPRMDRYLERKDLAFRWSSLLLSANRDATKSTGKTNGLRFRNKTKPISIGNKVLTHGTSEVCKAIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W6PST0</accession>
    <name>W6PST0_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Signal recognition particle receptor subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PROQFM164_S01g000739</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SRP receptor beta subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PST0"/>
    <dbReference type="STRING" id="1365484.W6PST0"/>
    <dbReference type="OMA" id="WWIAQRI"/>
    <dbReference type="OrthoDB" id="41266at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019009">
        <property type="entry name" value="SRP_receptor_beta_su"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09439">
        <property type="entry name" value="SRPRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10 12" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDM26930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="316" mass="34333" checksum="CB5661FB256F9EDB" modified="2014-04-16" version="1">MSSQANWNSVTGIATLLFDGNLVAIAIAVLFTFGVPIALHIFFFQTVASPPSSNFLLLGPSGAGKTAFTTLLEAKSSLASNKSHSTHTSQESTLVTVTLPPTVPTGSNRYRSVNDPSLKEAVRNPIKYRIRDTPGHGKLRVSQGISELQTMSRSKDIKTRLRGVVFMVDTAALVDEVTLRDTATYLHDVLLFLQKRAKNGSSSKRTTDVPVLVAANKQDLFTALPPGAVREKLEAEIDRIRTSKTKGLLDASADTGLEDEEEEILGNDEQETFSFKLLEHEVGVKVDVVGGAVKGDSQEEFGSGVRRWEEWVGMCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W6PT46</accession>
    <name>W6PT46_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BTB/POZ fold</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g000725</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PT46"/>
    <dbReference type="OMA" id="GCFLQFQ"/>
    <dbReference type="OrthoDB" id="3926209at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843:SF3">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM26916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="288" mass="32247" checksum="C6E0EE702C89F1D1" modified="2014-04-16" version="1">MDKSQTPQVRVPGETPESTQPEPNATANHNSTEVEMGETQDTSQPEPEHVQEDSTLSDVQAEPELPAPAKKNAGCNFLDFLTSPIVEIIVGKGDDETVMTAHQSLLMEAPLLAELLRKFEASGPRRINLSEEDVDAFGCFLQFQYTRDYTVVQTETPGETVEDKSGDELLRHARIYTLAEKLGLPKLQRIAHGKIHKVQSSPDAELSYARYVYTHTPATDTTIRKPVATYWASQSHLLRQEVGDNFKKLCIEVPEFSFDVLTIILDRKLKNGSVDEIKGSARKRRRDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W6PU23</accession>
    <name>W6PU23_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tetratricopeptide-like helical</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S01g001181</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PU23"/>
    <dbReference type="STRING" id="1365484.W6PU23"/>
    <dbReference type="OMA" id="VCCEIGQ"/>
    <dbReference type="OrthoDB" id="272077at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051726">
        <property type="entry name" value="Chitin_Synth_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46430:SF3">
        <property type="entry name" value="ACTIVATOR OF C KINASE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46430">
        <property type="entry name" value="PROTEIN SKT5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="158"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="241"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="666"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="167"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="243"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM27370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="696" mass="75814" checksum="56C7C84FC34CE7F6" modified="2014-04-16" version="1">MGPVRAASSGRPGRPDRDYPDSMGPSMHPPPRSATMPLAPGAPLYSGAPLYPGQSTYQETDYPASSMKEPLMRPDTAGSMRPPRSRAPNDIDPGLMIPATTLMIPPEPANRVSYAPKDFLDSYYESGAGAADEPDMPNFDAMPDPRHAPIDEMGLDITPVKRPVHGPTSSLEEYSYTPNGSEAMKSQSQPNFQQADGAGANQFENAGFQFGIPGEASHAPAFDHPGSAGYVSNGYEDYAGYSHGSSPVRSNQPGYSHDQAEMSDPHQNPDTLTHHPAPFRPGHDQGSKPAPVRQYITPESIPALAAPQPMMPSGTVQAPVTIEEIQRLQQQARANPSDQKTQLLLVKKLVEASTVLVEDNSRLDPKTKAKAKEKYVMDAHKILKKLVTAGYSEAQFFLADCHGEGLMGLEVDPKEAFSLYHSAAKQGHAQSAYRVAVCCEIGQEEGGGTKRDPFKAVQWYKRAAALGDTPAMYKMGMINLKGLLGQARNPREGVSWLKRAADRADEENPHALHELALMYQNAGGNDIIVRDEQYASQLFHHAAELGYKFSQFKLGTAYEYGLMGCPIDNRTSIIWYTRAAAQGEHQSELALSGWYLTGSEGILSQNDTEAYLWARKAATAGLAKAEYAMGYFTEVGIGAAANLDDAKRWYWRAAAQGYPKARERLEDLKKGGSRMQKTRLSRSAVNKQSDGDCVLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W6PUE7</accession>
    <name>W6PUE7_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g001639</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PUE7"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM27828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="63" mass="6950" checksum="3162158F7D889693" modified="2014-04-16" version="1">MEDAGRLLPGTPKQQRESFGARDAARKKAVEGQYRLHGSQCHLTIRQAEVCFVSSEFAASTRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W6PUF9</accession>
    <name>W6PUF9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PROQFM164_S01g001202</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PUF9"/>
    <dbReference type="OMA" id="NSATWIW"/>
    <dbReference type="OrthoDB" id="196103at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010291">
        <property type="entry name" value="Ion_channel_UNC-93"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051617">
        <property type="entry name" value="UNC-93-like_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294:SF19">
        <property type="entry name" value="DUF895 DOMAIN MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294">
        <property type="entry name" value="ET TRANSLATION PRODUCT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05978">
        <property type="entry name" value="UNC-93"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="98"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="252"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="283"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="316"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="418"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM27391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="470" mass="51966" checksum="C40DBCEB45C44A5F" modified="2014-04-16" version="1">MSASVHSEDKANVSTTVESQDEHPPPRPKFFYSTLFQILVVGLCAFCAPGIWTAMNGLGVGGSQSPDLVNAANALLFAFMTLTCFAGPFITNAIGFRWTLTLGSLGYPLYAAGLYLNNRTGATWLVYLGCVTCGISAGFFWSVEGAVATGYPEHHKRGRYIATWFTFRNFGNIIGGAVSLGINHTVDKRGQVGYQTYLAFIAIQCLGLVIGPLLSNPEKVQRDDGTRIEAPRGIHWREELSAMWRLARSKSILLLVPLFWYFGWIQAYPGTYLATYFTVRARALGGFMSAVVGTMATWLGGSLVDLPWLKNRKHRAIVTFIVIALMNTATWIWAVIIQNEYRHTHPVLDWGDQRTFGRGFGLYLFERISLGLVENYIYWCIGNLSDSPGDQIRYSSLLRGIETAAVAVGFGVQAVPTALIATASINLGLWFIALPFSYYATLQVVRKFELLKEQSPDASDRVAEQDVAER</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W6PVS9</accession>
    <name>W6PVS9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S01g002134</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PVS9"/>
    <dbReference type="OMA" id="DSCRQPT"/>
    <dbReference type="OrthoDB" id="2896390at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM28323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="157" mass="17175" checksum="2FA3DBDDE94AAC68" modified="2014-04-16" version="1">MPSMCWSLPNRSRTGAAIQLQSEETAAIIAVTQGFLAALSSKSRTDFEKHCVRAGGMTLSPPSPTSLRFCTIGSFVEHVAGLKDDIDERIWDPEVKVHETGSLNLAAVWAPFRAKINGVVDHVGVELFVLHKLNGEWKVTGLADSCRLPTEEEMLLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W6PVZ4</accession>
    <name>W6PVZ4_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Wings apart-like protein C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S01g001896</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WAPL family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PVZ4"/>
    <dbReference type="STRING" id="1365484.W6PVZ4"/>
    <dbReference type="OMA" id="NNKPKAC"/>
    <dbReference type="OrthoDB" id="5976022at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039874">
        <property type="entry name" value="WAPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022771">
        <property type="entry name" value="WAPL_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22100">
        <property type="entry name" value="WINGS APART-LIKE PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22100:SF13">
        <property type="entry name" value="WINGS APART-LIKE PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07814">
        <property type="entry name" value="WAPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Wings apart-like protein C-terminal" evidence="3">
        <location>
            <begin position="361"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="66"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="130"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="161"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="180"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="211"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="243"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM28085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="821" mass="89861" checksum="FD1EAD23A6AE0059" modified="2014-04-16" version="1">MENSHPRNRRLVTYGSAAKSQPPLNNERPVHSSAAKTTPKDMPLPKSSRLSRPFHTRLQRDKNGDKQPSGSEKMTTTRSLTQSKPIMEPNVYDLPSSDDEHMSMVQRKRRRYSPDGNKAIPVTKPSVKPNETEMRDRKVSPQMEKRVPNSRWPLAKKPEADQQTNPAGSTSYSRARRSVRNQTKVSTLENEMEISTEGSFGDGESVRKSSPDVNQGYATKANTTPGRRRLIDSLGITEHTVETSPAIETSPESPSSSQPSRDPAPVDRASPSAAVNECPAESQIQGSPASVPSHLRGSRVTYARQRSFLDDMVMSEDPSMQDAPSGPKHRSQSVQRQLNYEATSSARLIVPIEDTNEDGSVRSIHELRQAGGNARYRGAVESIFEDIEDPQNSLTGRCNAILQLCGKLLDTGLRRRFVECNFDKRLVDCLSMDLQVVPTILAFCAYALGSSDGHMSYVLATSAWPKLLSASPALLGMQDDILVTARAKASGLPRHLQNTIRGTIPQISAVLFPDTASSKLSPCTLALYCLRSTISTMQTKGKNPSLSTSLLKPLVQVLVSESQRCVSLEKLHPESSQILCMGFSILEASTALAESLTKEQWDILGPLSELHSLLSLESGTVSQIQPLYIRLILNVTNSNPSFCDRFANSEIVGGLVRIVSANFGDLTEDALGQANNSLDSVILALGALINLTEQSEASRTIFLHSAGSSKPFLDQLLHLFMTHVDSISTAHSVLEVHHNVAVGYLAVLLLTLNLDPDTRSKIKSSLAPNGLAVVISTVDEFLQYHQKIEQETSTFPTQGQPASGFLSRLQELVTRIRLAEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W6PWQ0</accession>
    <name>W6PWQ0_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PROQFM164_S01g000188</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PWQ0"/>
    <dbReference type="STRING" id="1365484.W6PWQ0"/>
    <dbReference type="OMA" id="HFFIVPE"/>
    <dbReference type="OrthoDB" id="5376138at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000088">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF3">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="234"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="309"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="342"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="388"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="414"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="484"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="81"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="523"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="524"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM26379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="544" mass="60613" checksum="B6E82FFD885DE253" modified="2014-04-16" version="1">MDPSVPENPEASSFKDEASPQAIKTEAGRGADTHAEYASNSDTASQEDKPKLRTGGKPELTEDDCYEKLGFCFPTWKKWMILSVIFAVQMSMNFNTGVYSNAVPGLTEEFHISEQAARVGQCVFLVAYAFGCELWAPWSEEFGRWPIMQLSLLFVNIWQIPCALAPNYGTIVVCRVLGGLSSAGGSVTLGMTADMWEADDQGYAVAFVVLSSVGGSTVGPFFGGMIGQWLTWHWVFWIQLIVGGVTQILHFFIVPETRTTILIDREAKRRRKNGEDIWGPDELKTPRLDYHDVLRIWIRPFVMFVREPIVLFLSLLSGFSDALIFVFTESFALVFAQWSFSVLAIGLTFASILIGYIIAYVIYLPDIHRQIQTRRQYGTASRLAERRLLLLLFIAPLEPIGLLGFAWTSTGPPIPWIAPCIFACLIAMANYAIYMATIDYMVAAYGPYSASATGGNGFARDFLAGIATMYSTPMYQNIGKRYHLQWASTLLGCVGFLVLIPIYVFYWKGPDIRAKSKFAQQLAADRERNTESRRASRARASVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W6PX18</accession>
    <name>W6PX18_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S01g002127</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PX18"/>
    <dbReference type="STRING" id="1365484.W6PX18"/>
    <dbReference type="OrthoDB" id="4424523at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM28316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="247" mass="28545" checksum="1F3D067D5E888C61" modified="2014-04-16" version="1">MPLDTSSSRFSNFGLLTFALSSKSSHELYHKLKVHPNWGYVIYRTTYSPESDAHFSTAVKYVEAFVKKSFFRECASKNESSPSVDPAIYEEIQAKYSSTVIEDAALFDGASIDSIRAHFEAWVDVQGQRDSFNKYRMCIVIDEECLQTLLGTSAEALEQETEYKRDKTKRYVKIEHAASPPAIVLRYLDDDLLEASNSQRLIDRHQAHQCTSELRKWRILFRHISLRYIQRQSSDKQFCSSHLDIHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W6PX26</accession>
    <name>W6PX26_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Oxoglutarate/iron-dependent dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PROQFM164_S01g002574</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PX26"/>
    <dbReference type="OMA" id="QFFGQHY"/>
    <dbReference type="OrthoDB" id="69177at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031418">
        <property type="term" value="F:L-ascorbic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004656">
        <property type="term" value="F:procollagen-proline 4-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.620:FF:000021">
        <property type="entry name" value="WGS project CABT00000000 data, contig 2.8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045054">
        <property type="entry name" value="P4HA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044862">
        <property type="entry name" value="Pro_4_hyd_alph_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869">
        <property type="entry name" value="PROLYL 4-HYDROXYLASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869:SF236">
        <property type="entry name" value="PROLYL 4-HYDROXYLASE ALPHA SUBUNIT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13640">
        <property type="entry name" value="2OG-FeII_Oxy_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00702">
        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 8" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="7">
        <location>
            <begin position="145"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM28763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="261" mass="29101" checksum="2D010BC92D451655" modified="2014-04-16" version="1">MAPKPKSKKPDPNPQPKTTTPNWPPLRPLLPATDLTLTPVLPDQIYLIRNFLPGTLCKTYTSFLASLPLTTTPGAPKKDEALRVNDRFQIDDARFAEMLWSTTALKELVTTRFDEDESDEDDGSHSPALGLAERARQLWDGEPLGLNPNIRIYRYSAGQFFGQHYDDANNITLPPPNSRSKATPARTTWTLLIYLTSCTGGETIFYPEPTRANRHPEPIAVAPEVGMALLHRHGDHCMIHEGAEVTGGEKWVLRSDLVVPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W6PX64</accession>
    <name>W6PX64_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 4">Nuclear transport factor 2</fullName>
            <shortName evidence="4">NTF-2</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ntf2</name>
        <name evidence="6" type="ORF">PROQFM164_S01g002614</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Facilitates protein transport into the nucleus. Could be part of a multicomponent system of cytosolic factors that assemble at the pore complex during nuclear import.</text>
    </comment>
    <comment type="function">
        <text evidence="4">Has a role in nuclear-cytoplasmic transport of proteins and mRNAs.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PX64"/>
    <dbReference type="STRING" id="1365484.W6PX64"/>
    <dbReference type="OMA" id="QFVEYYY"/>
    <dbReference type="OrthoDB" id="6507044at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00780">
        <property type="entry name" value="NTF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.50:FF:000005">
        <property type="entry name" value="Nuclear transport factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045875">
        <property type="entry name" value="NTF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002075">
        <property type="entry name" value="NTF2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018222">
        <property type="entry name" value="Nuclear_transport_factor_2_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12612">
        <property type="entry name" value="NUCLEAR TRANSPORT FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02136">
        <property type="entry name" value="NTF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50177">
        <property type="entry name" value="NTF2_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="NTF2" evidence="5">
        <location>
            <begin position="7"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00026247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00053082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU369002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDM28803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="125" mass="13864" checksum="F337F93DFEFCA06D" modified="2014-04-16" version="1">MADFNAIAQQFVQFYYQTFDGNRAGLAGLYRDQSMLTFETSSVQGVTAITEKLSTLPFQKVQHQIATFDAQPSSGDGIVVLVTGALLVDEEQKPMNYTQCFKLQPDGAGSYFVLNDVFRLIYSAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W6PX79</accession>
    <name>W6PX79_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SAC3/GANP/Nin1/mts3/eIF-3 p25</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g002629</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PX79"/>
    <dbReference type="STRING" id="1365484.W6PX79"/>
    <dbReference type="OMA" id="WTWEKLV"/>
    <dbReference type="OrthoDB" id="2100128at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39398:SF1">
        <property type="entry name" value="CSN8_PSMD8_EIF3K DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39398">
        <property type="entry name" value="YALI0F14311P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="297"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM28818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="317" mass="35677" checksum="9D803AD3DAEA8277" modified="2014-04-16" version="1">MSTHGHGKMSRLRPVSDSLENVGFVSKGDKKLLDHKIQTQYFDNIVDRYMRFCAHHSKDLDAALASLPTSPSNDATSNPPASRSPLKSNPAQKQVSPATELSTLLLSLRKLREAVLATATTTPAEFSQRVHVFSIRLSILAHHPPSYFPSLRYVLDKLHSPSHPLPGAEANELVTYLILDYACRQGDMIAAYELRARARKEHSYQSQTVDKVLAALIHDNWVVFWQLHNSVDSHIRAVMNWAADRVRRHALKAVGSAYLSVHISWILGGCTGDEQSWTWEKLVEKEKLRWEREGDRIIIKRPKQKTPPKPEPSASSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W6PX94</accession>
    <name>W6PX94_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cytochrome b-c1 complex subunit 8</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Complex III subunit 8</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">qcr8</name>
        <name evidence="12" type="ORF">PROQFM164_S01g002386</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The complex plays an important role in the uptake of multiple carbon sources present in different host niches.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein, 2 core protein subunits, and additional low-molecular weight protein subunits. The complex exists as an obligatory dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with cytochrome c oxidase (complex IV, CIV).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Mitochondrion inner membrane</location>
            <topology evidence="1 11">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the UQCRQ/QCR8 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PX94"/>
    <dbReference type="STRING" id="1365484.W6PX94"/>
    <dbReference type="OMA" id="QWAIERN"/>
    <dbReference type="OrthoDB" id="6683853at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045275">
        <property type="term" value="C:respiratory chain complex III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006122">
        <property type="term" value="P:mitochondrial electron transport, ubiquinol to cytochrome c"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.210:FF:000001">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.210">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004205">
        <property type="entry name" value="Cyt_bc1_su8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036642">
        <property type="entry name" value="Cyt_bc1_su8_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12119:SF2">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12119">
        <property type="entry name" value="UBIQUINOL-CYTOCHROME C REDUCTASE COMPLEX UBIQUINONE-BINDING PROTEIN QP-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02939">
        <property type="entry name" value="UcrQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81508">
        <property type="entry name" value="Ubiquinone-binding protein QP-C of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDM28575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="97" mass="11015" checksum="48D0A9888452FFF2" modified="2014-04-16" version="1">MGHSVDPKNGHYIGNWGEFGCPTPQRIATYSLSPNRQRPMAGAAHAAIFNVFRRFRHQVLYVAPPFIIAYVAMNWAIERNEFLNSKPGRLLEGDNEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W6PXI4</accession>
    <name>W6PXI4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RTA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PROQFM164_S01g002307</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PXI4"/>
    <dbReference type="STRING" id="1365484.W6PXI4"/>
    <dbReference type="OMA" id="WIFIGVD"/>
    <dbReference type="OrthoDB" id="1844152at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF8">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14140)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="88"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="133"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="168"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="215"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="257"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDM28496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="321" mass="35903" checksum="1B354BACDFE62135" modified="2014-04-16" version="1">MVEIRAAAKCTEVTPQCPVEGTIYGYAPDLVFSVEFCLIFGACSLIQLGQMIRWRLWSFSIAVILGSSTEVIGYFGRILLNRNPYSSAGFKTQICTLTLAPAFWSAAIYLTLKHAVNILGQQNSALRAKWYPYLFVTCDTVSLILQGAGGGLAAAAKTTKASDMGSNVMLAGIVWQVVTLTIFGVMSGHFLLRIKNAPKDGLTVEARKVWNSRNFWVFFWGIFVAFITTYVRCVYRIAEMAGGWKNHIMQNELDFTILESIMCSVSVIALCITPPGYFFPQMRGDYTRLVKEVDVKEMKDVKDVKVSISLWPEPPRYQEFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>W6PY86</accession>
    <name>W6PY86_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">L-ornithine N(5)-monooxygenase</fullName>
            <ecNumber evidence="5">1.14.13.196</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">L-ornithine N(5)-oxygenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PROQFM164_S01g000748</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-ornithine + NADH + O2 = N(5)-hydroxy-L-ornithine + NAD(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:41512"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:78275"/>
            <dbReference type="EC" id="1.14.13.196"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-ornithine + NADPH + O2 = N(5)-hydroxy-L-ornithine + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:41508"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78275"/>
            <dbReference type="EC" id="1.14.13.196"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Siderophore biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the lysine N(6)-hydroxylase/L-ornithine N(5)-oxygenase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.196" evidence="5"/>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PY86"/>
    <dbReference type="STRING" id="1365484.W6PY86"/>
    <dbReference type="OMA" id="YHGNTNY"/>
    <dbReference type="OrthoDB" id="3519933at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019290">
        <property type="term" value="P:siderophore biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000195">
        <property type="entry name" value="L-ornithine N(5)-monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025700">
        <property type="entry name" value="Lys/Orn_oxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42802:SF1">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42802">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13434">
        <property type="entry name" value="Lys_Orn_oxgnase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0274">FAD</keyword>
    <keyword evidence="7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="11" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9" id="KW-0521">NADP</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CDM26939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="491" mass="55126" checksum="614F7266E7034AEB" modified="2014-04-16" version="1">MEPVTRKELSFLDMVPRTQPQAARSLLRPTGAGEMHDLLCVGFGPASLAVAIALNDAMDPTLGALKDPNFKPKVCFLEKQNQFAWHSGMLVPGSRMQISFMKDLATMRDPRSSFTFLNYLHHKKRLIHFTNLGTFLPARVEFEDYMRWCALHFDNVVNYGEEVVEVVPGPTNARGIVDFFTVVSRNTGTGEISSRNSRKVVIALGGKAKMPPGFPQDPRIMHSSKYCTHLPQMLTDDMAPYNIAVVGSGQSAAEIYHDLHRRYPNSRTTLILRDSALRPSDDSPFVNEIFNPERVDKFYEMSAEERKKRIAIEKATNYSVVRLELIESIYNDMYLQRVENPDETQWQQRILAETKVARIEHHNASNRMRIHVKSVKNENEGKEVLDVDALMVATGYIRDAHEELLENVRSLRPAGASAWNPGRDYRVSLDSAKVSAQAGIWLQGCNEQTHGLSDSLLSVLAVRSGEIVGSVFADQLAGAPVVQDTRVRAML</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W6PYH8</accession>
    <name>W6PYH8_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">GPI inositol-deacylase</fullName>
            <ecNumber evidence="9">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PROQFM164_S01g002891</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Involved in inositol deacylation of GPI-anchored proteins which plays important roles in the quality control and ER-associated degradation of GPI-anchored proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the GPI inositol-deacylase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="9"/>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PYH8"/>
    <dbReference type="STRING" id="1365484.W6PYH8"/>
    <dbReference type="OMA" id="DERSIWQ"/>
    <dbReference type="OrthoDB" id="4349937at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012908">
        <property type="entry name" value="PGAP1-ab_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052374">
        <property type="entry name" value="SERAC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48182">
        <property type="entry name" value="PROTEIN SERAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48182:SF2">
        <property type="entry name" value="PROTEIN SERAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07819">
        <property type="entry name" value="PGAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0813">Transport</keyword>
    <feature type="domain" description="GPI inositol-deacylase PGAP1-like alpha/beta" evidence="11">
        <location>
            <begin position="78"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="12">
        <location>
            <begin position="362"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDM29080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="406" mass="45825" checksum="F43A6D606BAC7CA9" modified="2014-04-16" version="1">MVNSRLLMYQFFRKQHRAKPDPHSDNSSSSRDSIKSSRSLFSLSKPLSRTSAILVDQAEDVKGPLGLNLLYSPTVPEIDVIFVHGLGGSSRKTWSKSSLQSHFWPKEWLSKDPAFQNARIHSYGYDSYYLKGREDCLNVHHIGKTFLSAISTSPCIMNSATYIIVIGHSMGGLVMKKAYILAKQDKVHKALSERFTALYFLATPHRGADSAKTLRYLLKIAYDRAYVGDLEPNSGAIQVINDEFRHFSAGLELWSFYETQNMKLFSSLIVDPESAVLGYREEKQIPMAADHRSICKFDTPEDSNYALLRNALASTVSKIATAIAELKLKQRRERIKSLKNYLEIFNMLDDDFANVCEARLHGSCRWISTKASYVKWREGESGNDRTLWIKGKPATGKSVLAGYVID</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W6PYL6</accession>
    <name>W6PYL6_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S01g002632</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PYL6"/>
    <dbReference type="OMA" id="LHYLYSP"/>
    <dbReference type="OrthoDB" id="10034502at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013744">
        <property type="entry name" value="SidJ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31591:SF5">
        <property type="entry name" value="DOLICHOL-PHOSPHATE MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31591">
        <property type="entry name" value="UPF0613 PROTEIN PB24D3.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08538">
        <property type="entry name" value="DUF1749"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM28821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="344" mass="37700" checksum="CF7867F858D12553" modified="2014-04-16" version="1">MSSNASRGPSHSGFLHEYAPRLVAFEFTPPTGGINKTNSLIFIGGLTDGFSTVPYVSKLANALEDTDWSVFSTLLSSSYAGWGVGSLDRDVEEIGQCVRFVRDLKASRQPGAVTTAGKIAIMGHSTGSQDVLHYLYSPNPLPRKEFGFGIQHLVRPALDGAILQAPASDREGLQAIIDASPEPDELRKVYDQLVRSAKEHPYTSDKNDSILPMNLTAKLSYPADTPLSARRFLSLVSPHSPDDPSDDDLFSSDLSDKRLQETFGMVGTQGIITSKLLVLYSGEDEYCPHWVDKEKLLRRWQQAIEAGGAKWDTNSGIVPEASHNVHAEGQQDLIDRVLRYLKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W6PYV4</accession>
    <name>W6PYV4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g000948</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PYV4"/>
    <dbReference type="STRING" id="1365484.W6PYV4"/>
    <dbReference type="OMA" id="SFETMWR"/>
    <dbReference type="OrthoDB" id="10029320at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20626">
        <property type="entry name" value="CYP_Pc22g25500-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM27139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="436" mass="49370" checksum="4A4650F196F4987C" modified="2014-04-16" version="1">MSRETNFASNDPAICRRIIAGVLKHKDQPNNLSPHQAKAISNKHLPVAFGIDNAFTRTERAHADMFVEKVKRLINISTEQWYGVSEFARVTTSHWIEHGFPGMNHSCGNSGHKGKNDVKFTTGRNRINVASLAQILSLKVVLWLMFDKKTQDETGHENLLNLAESINRVWISSKLKATENDIPRYEDDVLLQTSLVNIFGQHDRPEDNPLNLILPSFETMWRIVLRGFLETRFASGKEEPLWRETMIAFAMNPTKSQFDGPPSTRPKSESRVNPSIGDTHAIQSSPCAKHIVRESLRLYVPTRHIHRAYQWQPGMGTSHEIRSADIEGCHLRSDIWGSDAERFNPDRWSFLTPAQGDAFMPFGSAPFECPAKPTFGPRMVGVLVGSLLAALEDKEHPRTWILDCEDGKVLEHVTSGKRLCPHRNSYTDLYLVRSTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2024-10-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>W6PZF5</accession>
    <name>W6PZF5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S01g002922</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PZF5"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM29111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="73" mass="8536" checksum="EB22318E1DB13EA1" modified="2014-04-16" version="1">MIWKHTRLFLSFVDIQVLKYHPEVPRELSSAIMSKFSMAENMPDGSIREMNFFDSSFFKEPNKSLPTPARVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W6PZG4</accession>
    <name>W6PZG4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g003242</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PZG4"/>
    <dbReference type="STRING" id="1365484.W6PZG4"/>
    <dbReference type="OMA" id="IKHACAM"/>
    <dbReference type="OrthoDB" id="4188313at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="372"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="461"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM29430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="482" mass="52919" checksum="5734C243A62B123B" modified="2014-04-16" version="1">MERKLSAKASQIRHRLTFTRSNSARALEPTLVSPIEVSPPSSRPRSATNPESPTHAEPTWHRDPGPSGGYSFTDEPGYFRPASPFIDRQEIEEDLEDDIKHACAMLSHSIDRGMPAGLSYRSAVTVGQNPQPSVDAAPSSLKQHVVLLSAINLQADSTKRHDSGVGMINSPSQKRRPSGNSVSGTNISARFYNKQPSASPPHSPSPGTRSRGQSLEVTIEDKERGRACSPSLIPFYSPLQMNSEWTWTSKPTTLHSPVSSLNDTDKRFEVTESELKTHPHEIATDTNAIPETFSPAISPHEAPLGWTGRTWLHVSGDIPCLIDENAPTEAKQAKPMARFYSSCNRTTGSLRSREWPPKDYWEEQDLNVHGKVTPDSLLGSGRETLSRPETGISRLGSASTNEEDSPGGYLYPPFADPNRGMSYSSSCLADDMYQERIYSVAMPGSPKNNRRNKASLLLRKLAGLGRKKDNDNGNEFIDGSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q042</accession>
    <name>W6Q042_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S01g003462</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q042"/>
    <dbReference type="STRING" id="1365484.W6Q042"/>
    <dbReference type="OMA" id="FFHDANG"/>
    <dbReference type="OrthoDB" id="4358740at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM29650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="126" mass="14457" checksum="5ACF795F85B41E55" modified="2014-04-16" version="1">MRSESEKQRKYADYDVQEDDTPDTRLLAIQKWRVCTLFIFDISNNYWDPTLGHLAEQNKLPVVVAHLSRRKVAYKPHPGTRERINKDVAFFHDANGFGGTPPFIEDHTLESPPVYSNSRSLVNSGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2024-10-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q2A1</accession>
    <name>W6Q2A1_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S02g000584</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q2A1"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM30435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="35" mass="3752" checksum="5BE5FDD4D0F9F0DA" modified="2014-04-16" version="1">MVHAAVSRARLKTVSRATDPEGTYPADSTLVSNFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q2R7</accession>
    <name>W6Q2R7_PENRF</name>
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        <submittedName>
            <fullName evidence="3">Capsule synthesis protein, CapA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S02g000998</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CapA family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1365484.W6Q2R7"/>
    <dbReference type="OMA" id="CGDVMTG"/>
    <dbReference type="OrthoDB" id="189619at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Capsule_synth_CapA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052169">
        <property type="entry name" value="CW_Biosynth-Accessory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33393">
        <property type="entry name" value="POLYGLUTAMINE SYNTHESIS ACCESSORY PROTEIN RV0574C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33393:SF11">
        <property type="entry name" value="POLYGLUTAMINE SYNTHESIS ACCESSORY PROTEIN RV0574C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09587">
        <property type="entry name" value="PGA_cap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00854">
        <property type="entry name" value="PGA_cap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Capsule synthesis protein CapA" evidence="2">
        <location>
            <begin position="8"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM30848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="376" mass="41423" checksum="D169016D8C13C676" modified="2014-04-16" version="1">MSTPKSFTLTFTGDVMLGRLIDQLMPKHVTNEQDERVVKTFIEAHPTFFSKGNYTPTSPWGTALRILHSSTLACINLETAVTTAPTPWPNKAFNYRMHPANLGPILHAGGVDYASLANNHTLDFGISGLTETLQTLQSANIAHAGAGETADGARKPAVLYLPRASEPIEQSQHRHTVHIYSATDHPHAWISVPGFNLFDYTRDTRARLREMLVGAEATKPALKVFSVHWGPNYAWHPDARVTSLAHFLVDECGVDIVHGHSSHHVQGVEVYRGKLIIYGCGDFVDDYALNTEYRNDLGALWRVVVREKGGGSGLGLERLEIFPTRVERFQARLLDSGDADHGWVSHKIRELSAHLGTAVNAELGREGEVVVELSGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q426</accession>
    <name>W6Q426_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S02g000861</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q426"/>
    <dbReference type="STRING" id="1365484.W6Q426"/>
    <dbReference type="OMA" id="IQMQTYR"/>
    <dbReference type="OrthoDB" id="4181307at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034443">
        <property type="entry name" value="PB1A10.08"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42051">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED PROTEIN PB1A10.08"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42051:SF1">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED PROTEIN PB1A10.08"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="317"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="74"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="175"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM30711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="482" mass="54053" checksum="0BCE846219242C57" modified="2014-04-16" version="1">MMVPRAFLFSSAPPQKPFQSHGMNPSTPPDYSSLLSTPNTESRRSINTIPVVIPPKRGSRTLPPRREIRSRALSKTSESSHRSSSSSSSDRPIPTSFTLMLDATAIPVPRRNWTARRPRKLPRGNHVEDFSRMLQEDIESKEESFLDGAAYSPLDILLSPPDKLLPCHDSEHESPPSVRSTSSDSIPSLDHGLASPSSLLSPPTPSNHRSPPERRQPRYSNCEECDLDHPLLRNEIDIDELEYIEIKNDNGPATPDAVPARRSASFGRLGSSFKSNLTASLRAIKSAAQSVSTFATPSVQTEDFLTRSLFTITPEMTDDRRPLPMQETPSPALRRYLNPSPMNPTPMSPAEMYVYHDHPLDKLQTSKTCPVSIQMQTYRRAGGRGNRRSHFHIASKDQKFVAFDPENPPMSRQREIRENSDFLRVVVLEMNMRRSGKLRDDIPARARIWLPARKTNSHLSGQYEDGDDNNAVPTRWVGVSAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q4A5</accession>
    <name>W6Q4A5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S02g001325</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q4A5"/>
    <dbReference type="OMA" id="GYYCRAC"/>
    <dbReference type="OrthoDB" id="4238722at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="395"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="395"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM31175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="438" mass="48690" checksum="5C8DFA1A748B5477" modified="2014-04-16" version="1">MSLRPLGYQCKLPYAQLFRNGLQTKQNITQHLRSFSQLRDTHCARRWSATFPHHANKAFSLRSLLGDLLRPAHTIRGQGKGLWAQQSRYESSAAKEPELCAHCGGKTIPKARKHVEPGNPSSGWYCKPCVRNIRAHGHLPNEEQLAGIHRRRLIRASGEASKTSPCGHCGQMTAPRSSRKFIDANNPSAGFHCRTCVRHVNHHGTLPTDLDLAAFQYRKQMRSRRPPTVASKNNKSVTSTGESAVARKPSKSPKQMKQSRGEYPCMHCGDKTISSSKRRLVEPQNPAAGYYCQPCTRSLLETDALPSTVKIAALRKLRATRMQSNPRVMKSPCVHCGEITAPSSKRRLVEAKNAQSGYYCRACADCLIETNSLPSDIRLAVRRAREQVRLKNLQASLSKESQSPVSPQDGEATPTDILTDNTAKTCAHCRTEENTSDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q4B0</accession>
    <name>W6Q4B0_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Transcription factor, fungi</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PROQFM164_S02g001330</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q4B0"/>
    <dbReference type="STRING" id="1365484.W6Q4B0"/>
    <dbReference type="OMA" id="FNAKAMY"/>
    <dbReference type="OrthoDB" id="9411774at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000190">
        <property type="entry name" value="C2H2 finger domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF8">
        <property type="entry name" value="C2H2 FINGER DOMAIN TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="23"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="51"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="119"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="119"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDM31180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="755" mass="84574" checksum="6617F41E22FE8D68" modified="2014-04-16" version="1">MAPSAPGTANSPAKKTSAPEKKYKCQFCNRAFSRSEHRSRHERSHTKERPFKCLKCRSTFVRRDLLLRHDRTVHAKDGGIPLVAEGRRRGGGVQKNSSAPARPSVTIDPTTLEQIEASSNDAAATGQVSERSESLSPGRGSFEPYLSGNATLPQMPWDTLISPAEPGSMPTLVDRHGPVGDLLMSNSLPMSGHSTPNAPSPYPSMTGPVSPVNYRRSPGPSQALTLPKAPQLANEMERNYVVDRIQGSDSLGALPDTFQLPSTVALNRYLSTYFNLYHPHLPFLHQESFKPSQVPAPLLLAVLSIGALYTFEREHAFMLHVGSKVLVNQFLQHKDNFDSRKCPLTLMQATLLNMVFESWSGDPKGLEWTCSIKSLLANMVAGNRYQLKLRTQARQNVQPSREEWIEDESCRRTYFAVYIFFGMLTLTFNHTPAMSFDEFDDLELPSSESLWNLDEADDESWRRGTVSSALTVREAHDCLFQGEQTRYSAFATRVLINALFLQVWSHKRSFEALQDVVTEYKLRLALETWENSLEVCEPETIVVPLSTPQKGHPLIFNSMAVYRNTRARLEVDLKSIQEAMRYHSSYEVAAAMTVAREKVKRSQEMNKVIQQCFECIEIAAIQGINWVAKTSATNWSVENPLCGLDLMVILSLWLYRLEHDDEPATEAELALYNKVRNLFDDDAIDAFGKLSSTVARVWGNILDGVVVWGITKLMGESFKLHSQALVGYEDSLRVRKDQPIHAVPTKSLASVGTAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q4H0</accession>
    <name>W6Q4H0_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PROQFM164_S02g001678</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q4H0"/>
    <dbReference type="STRING" id="1365484.W6Q4H0"/>
    <dbReference type="OMA" id="AMSCFRT"/>
    <dbReference type="OrthoDB" id="4454541at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF33">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="34"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="97"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM31528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="685" mass="77747" checksum="AF8BCC29E64FAEBD" modified="2014-04-16" version="1">MADQSECSPYSTVIEDESLHLIPAPTGKKRIPKACSACRQSKVKCDGERPCTRCQKLEKQCVFFEIPKDPVSERIEGVESEVQYLRKQLDQMRELFQQSRSQPTPKSQLTHSPSHLCDRQQDVPRESACGSRFPHSQDHPEGLFPHIPVTGSARYTNCHQYQRSMSGTIQTLSPNETSTQPPYARSQIITRPPKRKRSGFEIRDEPIADFIDKGLITLECAVSYFNTFFAGCDRYIPIFDPQYDTFDSVRSRSSILLNAICTIGCMVETRSGGGSMSDVLHAELKKWINVIIQNKQLNCRESIQAMLVVACYSAERSLILSFATRMALDLELDEAFDELTRRLALQNEDMAYALPHQMFEEERALMWNARTWFGLLVLEHIFRLDGGKPPGIRLKGNSRRCRVLLSHPWSTILDLRLFSQVELNILRANVGDALGGNTSLDGQSIADYVHDMKIELDLWFDDWLRIIEGCVAAAEEKPSLLVALRVQKCWTEMMLNCKALRSMGVENVAAMSTTERTILLTAKASARRHLRLIIADPDFYLAKLKYAMDFVWAKCAFSFLLLLKLSRLIPERDEEHQELLEQGNRLVDELSKAGASGTQSGAGNIYLQILKVSIEKYGRALMEAQQPSSDGPTDTSPFWELFDAQADLQWFVPEQFVSEWDFPGLNLFYFPTAWQDSLGDFSLAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2024-10-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q516</accession>
    <name>W6Q516_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S01g003076</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q516"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM29264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="36" mass="4083" checksum="2B0DE9CBB6922AB8" modified="2014-04-16" version="1">MEIRRIFHTPSKRDRANAAKGDGNILVFPGLIKGFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q5B8</accession>
    <name>W6Q5B8_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Autophagy-related protein 29</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">atg29</name>
        <name evidence="10" type="ORF">PROQFM164_S02g001989</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Plays a role in autophagy. Functions at the preautophagosomal structure (PAS) in order to form normal autophagosomes under starvation conditions. Also plays a role in mitophagy and regulation of filamentous growth.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Preautophagosomal structure</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATG29 family.</text>
    </comment>
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        <property type="protein sequence ID" value="CDM31838.1"/>
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    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2570:FF:000001">
        <property type="entry name" value="Autophagy-related protein 29"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ATG29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040666">
        <property type="entry name" value="Atg29_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039362">
        <property type="entry name" value="ATG29_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40012">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40012:SF1">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18388">
        <property type="entry name" value="ATG29_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0072">Autophagy</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Atg29 N-terminal" evidence="9">
        <location>
            <begin position="7"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="78"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="86"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="100"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="124"/>
            <end position="137"/>
        </location>
    </feature>
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            <begin position="138"/>
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        </location>
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            <begin position="163"/>
            <end position="184"/>
        </location>
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    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="221"/>
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        </location>
    </feature>
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            <begin position="272"/>
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        </location>
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            <begin position="346"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004329"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00010082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00060351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF18388"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CDM31838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="397" mass="43572" checksum="D9D44A15B4A003A5" modified="2014-04-16" version="1">MPVNTNFTVFIRLPFPRGDFVEWNASKDQALWDILSRPSKGDIDWKALAENFDVTLQFLLQQAAWLYDRQLSQVRAQMRKVGTTQSNSPSPAPGSVSGSTALGGQSQRETPAPGSRAPSRQVSHPKDIPLRAPENRRTSFTSTTPTNLTRGPRDPTRTATPTIDDKESRWDSLAHRPSAVRREQPPVASLPRSSPLEEESLSSSSSEESASDDDNTNRRAPLFKRFGKFSTHRLRDDEDDEEDTPAFLPLSREHGRIHRDRSGQELSATLRLDAERAAAQRRHPEQRPNPRVPAPTDSSTSSISSGGRSSLPGGPRRTSQGGSMLSPAERQNSRKSTASGREASDGTPSMGSSFSDLDDASVTQSALEEALLSNMQHGGMASRMSTISQALRSRYLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q5M8</accession>
    <name>W6Q5M8_PENRF</name>
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        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S02g002144</name>
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    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
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            <taxon>Aspergillaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
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                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
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                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
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                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
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    </dbReference>
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    </feature>
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        <location>
            <begin position="345"/>
            <end position="376"/>
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        <location>
            <begin position="1"/>
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        <location>
            <begin position="36"/>
            <end position="62"/>
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    </feature>
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            <begin position="354"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CDM31993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="405" mass="44891" checksum="359560D5A63677D5" modified="2014-04-16" version="1">MATRTSSRHAAQKAKEAISTSAEPTGKTSKGTKRRASGDEAPQPKKEKTEDIKPDELKKEEVPGTSVDRPVQKTEEASVKTEEAPVKTEEPPEGQASTVKPVESHPEKPQGIEGGLHKSEERENLVPSNILEKGFIYFFFRPRVDVDEPESFGDVARSFFVLRPTALGAEFDNGQDSVEKDASCRLMILPKKKFPTSSREREMGFVEKAGQSMQALHDNFIAGKTYQTSTRGERHTEAARPYAEGVYAITSAPRASHLAYILTIPAELGDVQEDFGLQERGSWIVQSKSPKFPGPPVGQLPKNPEFPPSVLEKFGDLRWVPLQPEFLDYPYSQFLMIGSAQNDLGKAASSMGDKQPKEEEPGQELEKMADEDEHRVDSLQGDATVYEDLGYHAKNYPKVPTTWNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q5Z5</accession>
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        <submittedName>
            <fullName evidence="3">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S01g003486</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
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        <location>
            <begin position="344"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="5"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="344"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM29674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="424" mass="50140" checksum="88F64CAF0C0AA3CA" modified="2014-04-16" version="1">MSNPRAEAAKEIELQELERQLKRRQLEFDVEKHEITLAHSKNKLENHELRIELQNQELRIQHDRAELEKEEFKLKEKIKGLQEIETGPNIIRLEISKKFTRGMEGSLEHEIRQTGDINALQRCRFELYIYEQDLDGKEDRLAEFLDVETRLREIAQREMRWEYYQLSGARVEQELSESNKEYKRVEREWWTIRGSFSDGPLTRAFELWRGNPKWYMHRVLREDCARRGGCCGRECGCCLDRKFIGDRRKHANGHCTVECGCCQKAGSFEISENKKNEFSIRYAVSQDGKKSHDFTDIRLKTLEMQNQHLQQQLSEEAMKDTVMENDFSDGIVAEYKRCINEDTLTDDEAEFTDESDDGCPPEEEEDPHYRRISLASIWGLVDGNFENPFDLIDEEMIYAPWQLVGRSEWPNQDENDSTMTETDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q6E1</accession>
    <name>W6Q6E1_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF1746 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S02g002399</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q6E1"/>
    <dbReference type="STRING" id="1365484.W6Q6E1"/>
    <dbReference type="OMA" id="DCSFFWL"/>
    <dbReference type="OrthoDB" id="5428737at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044695">
        <property type="term" value="C:Dsc E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032933">
        <property type="term" value="P:SREBP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038967">
        <property type="entry name" value="Dsc4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013715">
        <property type="entry name" value="DUF1746"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39405">
        <property type="entry name" value="DSC E3 UBIQUITIN LIGASE COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39405:SF1">
        <property type="entry name" value="DSC E3 UBIQUITIN LIGASE COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08508">
        <property type="entry name" value="DUF1746"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="61"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1746" evidence="3">
        <location>
            <begin position="58"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="183"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM32248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="337" mass="36801" checksum="69A988C6BDAC3168" modified="2014-04-16" version="1">MTDVDAFRDAEYIADVSGISYDDAEPPRPTGTLSSQNARVKKVKSTAKVAFIDRLLRDLDILIYCQLSALYYMDCSIVLFAIRAIVELIFFTPKAPPFEPTRHQPFVGAIIGSNLICMLFHAFLIRPEAGEETRGYLHGGLFIDFIGQAPVSVYRLLSFDLLILLIDFIMLGLIIERVKTNGTPTPVAATPNADTPTDTITDTSPDAEGSQSQDHDAEERGILRQEDGGETVSPAHDGNHIDEEVEDERTTLLADPADAESGSAGRGEHPMDTFAAGEAVIVNMSFLGTIRDQWRHSNAAARSTSGFVPSPETATFLRQRFGLQVGTDGRIERANAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q7E4</accession>
    <name>W6Q7E4_PENRF</name>
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            <fullName evidence="3">Genomic scaffold, ProqFM164S02</fullName>
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    </gene>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q7E4"/>
    <dbReference type="STRING" id="1365484.W6Q7E4"/>
    <dbReference type="OMA" id="YVCSAYY"/>
    <dbReference type="OrthoDB" id="434783at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR39599:SF2">
        <property type="entry name" value="ANCHORED PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G09650)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39599">
        <property type="entry name" value="GPI-ANCHORED PROTEIN (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004879415" evidence="2">
        <location>
            <begin position="23"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="252"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM30184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="435" mass="45155" checksum="9F355B76E069ACD4" modified="2014-04-16" version="1">MQLLHALAVFCSLPQFATLVLAENTNPSAERESKETNTRSLPAKIVIQRNAAIASQLASGPALGVKKMSENEGEKFFLDYWSFGEASSSSNISERHFSEEEGFSPARFVAQSYPFGPSYSPSTDEYSQYLPRENNSANNLFEKRDFKCPTGTLGCTSIGRSDRCCGSGETCEIVADTGNGDVGCCPSWQTCSGTIGSCESGYTACSQALGGGCCIPGYDCVEGGCAYITVITVTLHSTVMLSTVTYSTKPDSTSTSISTSTSTSTSTSTSSTTSSQSGTSTTDESLAPPARPTNLSTVTSDVCPTGFYACSAVYQGGCCRTGRDCDTTSCPTTSSTTMTSDGVTIVAPVATTTERSGGNLCAQGWFRCADTVGGGCCPTGFACGSSCTATDTASATTVTKEQATATAASGDGVVHRISKMMLGMTLGMCVGFWML</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q7Y3</accession>
    <name>W6Q7Y3_PENRF</name>
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        <submittedName>
            <fullName evidence="3">BTB/POZ fold</fullName>
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    <gene>
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    <organism evidence="3 4">
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        <lineage>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q7Y3"/>
    <dbReference type="STRING" id="1365484.W6Q7Y3"/>
    <dbReference type="OMA" id="LRICHCK"/>
    <dbReference type="OrthoDB" id="5275938at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="78"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM32500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="236" mass="25986" checksum="0321766E71879612" modified="2014-04-16" version="1">MAPRQTKSLRGLNLRKSTSATPMASTQEQEDTKPILTAVVAPDLHPPYQVDPDGDIILFTPKTPLIDISKGNVPGNYARFQVSSKHLALASAYFKRLLKDCWAEGSALSKKGSVEIPVNDCKPDILLVLLNLIHGRSRQVPLKLTLPQLSDIAVATDFFQCNEVVEVFAGIWIQALESLVPSSFSQDMKIWMMISCVFRSHSVIFQKTTKIAIQQATGPFDTSNLPIPNSIKGIQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q801</accession>
    <name>W6Q801_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S02g002666</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q801"/>
    <dbReference type="OrthoDB" id="3868412at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM32515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="63" mass="7345" checksum="EC44073AC7C961CD" modified="2014-04-16" version="1">MLYANNLQDPLINYMHYIFLSSCMSSTYDHRVWKTGLPVRSAVLKPHCCMFLLFAIFVLFIGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q863</accession>
    <name>W6Q863_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S02g002721</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q863"/>
    <dbReference type="OMA" id="IHTFAKP"/>
    <dbReference type="OrthoDB" id="4505711at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM32570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="84" mass="9220" checksum="ACF4A90380915026" modified="2014-04-16" version="1">MVAVRSLSDGYLKDMDIGAFSARLSLQFTTVVLLALVPSIHTFAKPLHTPSPLATAFGRLVLLNLYSCALYTLRPLKRIGIVQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q8X2</accession>
    <name>W6Q8X2_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Transmembrane receptor, eukaryota</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PROQFM164_S02g000819</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LU7TM family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q8X2"/>
    <dbReference type="STRING" id="1365484.W6Q8X2"/>
    <dbReference type="OMA" id="TWGFYDF"/>
    <dbReference type="OrthoDB" id="19932at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053937">
        <property type="entry name" value="GOST_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009637">
        <property type="entry name" value="GPR107/GPR108-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053938">
        <property type="entry name" value="PTM1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21229:SF1">
        <property type="entry name" value="GH17801P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21229">
        <property type="entry name" value="LUNG SEVEN TRANSMEMBRANE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06814">
        <property type="entry name" value="GOST_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21902">
        <property type="entry name" value="PTM1-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004879648" evidence="9">
        <location>
            <begin position="21"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="218"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="249"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="290"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="321"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="366"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="410"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="PTM1-like N-terminal" evidence="11">
        <location>
            <begin position="31"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="GOST seven transmembrane" evidence="10">
        <location>
            <begin position="183"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="458"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="499"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="521"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF06814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF21902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDM30669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="537" mass="60001" checksum="0FA2DAF83882DBE6" modified="2014-04-16" version="1">MKGWLQTLGLTALLASYALANDAELKSDDAHRQRCSGMYSRKAWGGDVDPFILVKFTKSEAQESDPLASLVIFEWSDEGLIGQYRSGDAEVKETICDASNVEAKICTQEQLGSFVLTSNATDVSKSPIISKAIHLNNPDAVKYPVRKTGFYCVSTYAYSGQDYKAVVTFRNSYGELPAAQIAKLPFYGALTIVYAVIGAFWAFLYVQNRYDILPVQNYITAIVVFLIVEQLMTWGFYEYQNRHGLNGGAKALMVIVAVLNAGRNAFSFFLLLIVCMGYGVVKHSLGRTMIYVRILAIGHFVFAVVYSVASLSITPDSAGPLVLLIVLPLAGTLTAFYVWTLNSLNATMKDLIDRKQKTKAMMYKKLWWCILGSIIVIFGFFFINSFAFAGRSDASFVPEHWKARWFVLDGWLNLVYLFDIAFVAYLWRPTVNNRRFAMSDELAQDDDGFEIRSFGSGLDEEDAYDAPPDYPGSSAAEGRDLSPVPPKPFSSAPRHRESLDEETIFAVGEEDAERWSDDEESPRNSSERQRLTGKDKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q941</accession>
    <name>W6Q941_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Alcohol dehydrogenase superfamily, zinc-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PROQFM164_S02g003340</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM33188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q941"/>
    <dbReference type="STRING" id="1365484.W6Q941"/>
    <dbReference type="OMA" id="CHSDCHN"/>
    <dbReference type="OrthoDB" id="1879366at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08297">
        <property type="entry name" value="CAD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000039">
        <property type="entry name" value="Alcohol dehydrogenase AdhP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940:SF2">
        <property type="entry name" value="DEHYDROGENASE FAMILY OXIDOREDUCTASE, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="8">
        <location>
            <begin position="18"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM33188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="352" mass="37017" checksum="1740CD5464D6FF75" modified="2014-04-16" version="1">MADSTPTLQQAAVVQNPGENATITLQNDIPVASPGQNEVLVKLTCTGLCRSELRAVLAWGAYNSIIGHEGVGIVVKAGPDVSESLLGERVGVKWLYSACNKCSVCKRGFPNYCAQQLNTSRHVPGTLQQYVIADARFLTLIPGGVADEVAAPLLCAGLTMVGALSKLDHELQVGDFIVISGSGGGLGHIGVQIASRIKNLRVIAVDSGDDKRALSLESGAEVFFDYKTEDVVARVREFTGEGAHATIVVPGTKEALQMAPNLVRNMGFVVNVGLPPNDLDIPLSATLCTARGLTFIGSSVGTEDQLTDLLQAAAAGKIAPSIEVFEFSDVPTLIEKLRDDGIMGRAVITLPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q995</accession>
    <name>W6Q995_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">C2H2 type master regulator of conidiophore development brlA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PROQFM164_S02g000909</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q995"/>
    <dbReference type="STRING" id="1365484.W6Q995"/>
    <dbReference type="OMA" id="QLPLYSW"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048315">
        <property type="term" value="P:conidium formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR PROTEIN YY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003:SF19">
        <property type="entry name" value="YY2 TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0010">Activator</keyword>
    <keyword evidence="12" id="KW-0183">Conidiation</keyword>
    <keyword evidence="8 17" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0749">Sporulation</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="68"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="98"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="130"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="184"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="12"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="27"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="141"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="184"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CDM30759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="308" mass="34441" checksum="8E29392DC8162246" modified="2014-04-16" version="1">MSFNTTSTASITPPFGFGYPTPTPSTLANHNNNASQTVNYPRPLVDVSSPPQENSHRVSKAMKGKRVHACQRPGCSKVFTRAEHRRRHELSHDPKKQYPCTYEGCKKTYHRPDYLTQHLVQHATSAPKENIPYAHSDRSSRQSSLQQQTQSQPAKSPAIPFQVDSTDSYPGIWGIMDSSMPYPQYSSGQSQSSASAHDHPSPYSYTTDICSSPVASESLLNPQYPTSGMPVETVTAIDQYLRSILKPEAFASPYQQTDPSIWSSDIDIDPTLAKIESLDQLPLYSWPPTHHLQYEDHPVQMNHPSDDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q9Z2</accession>
    <name>W6Q9Z2_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">LSM complex subunit LSm2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PROQFM164_S02g003382</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of LSm protein complexes, which are involved in RNA processing and may function in a chaperone-like manner.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the heptameric LSM1-LSM7 complex, which consists of LSM1, LSM2, LSM3, LSM4, LSM5, LSM6 and LSM7. Component of the heptameric LSM2-LSM8 complex, which consists of LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8. The LSm subunits form a seven-membered ring structure with a doughnut shape.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM33230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q9Z2"/>
    <dbReference type="STRING" id="1365484.W6Q9Z2"/>
    <dbReference type="OMA" id="DNISCTD"/>
    <dbReference type="OrthoDB" id="10256176at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990726">
        <property type="term" value="C:Lsm1-7-Pat1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01725">
        <property type="entry name" value="LSm2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000042">
        <property type="entry name" value="U6 snRNA-associated Sm-like protein LSm2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016654">
        <property type="entry name" value="U6_snRNA_Lsm2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13829">
        <property type="entry name" value="SNRNP CORE PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13829:SF2">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016394">
        <property type="entry name" value="U6_snRNA_Lsm2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 10" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 10" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="11">
        <location>
            <begin position="2"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR016394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDM33230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="98" mass="11260" checksum="63A202165F8BD6D7" modified="2014-04-16" version="1">MLFFSFFKTLTNQTVTIELKNDIRIRGILKSVDQYLNIKLDDIEVLELAKYPHLSSVKNMFIRGSVVRYVMLPRSEVDVGLLEDATRREAANQAGKAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q9Z5</accession>
    <name>W6Q9Z5_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Autophagy-related protein 14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PROQFM164_S02g001149</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATG14 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q9Z5"/>
    <dbReference type="STRING" id="1365484.W6Q9Z5"/>
    <dbReference type="OMA" id="HYRFEYG"/>
    <dbReference type="OrthoDB" id="72772at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000323">
        <property type="term" value="C:lytic vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035493">
        <property type="term" value="P:SNARE complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018791">
        <property type="entry name" value="UV_resistance/autophagy_Atg14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15157">
        <property type="entry name" value="UV RADIATION RESISTANCE-ASSOCIATED GENE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15157:SF5">
        <property type="entry name" value="UV RADIATION RESISTANCE-ASSOCIATED GENE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10186">
        <property type="entry name" value="ATG14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="44"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="348"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="555"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="270"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="81"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDM30999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="594" mass="66759" checksum="E24F8628B1F49B66" modified="2014-04-16" version="1">MDEDTEQDIGARRERPWLYAWNRRLRHLQGISIRNLVVTPPPARAHGKTIDDDDIPNTLKTPSKILSQSTNRTLQPSRSFTDLKSHSSQHDNAKEPAMPSMRRRSTLFWNDPNPQIRQVRLEDITNSRMADTFFSLHCDGLNKPVYISETVDRANNPSFRFFDLNLCGPYISRMDELTLRLWAKTGDMSGFILLVELQLHLRSLQFLGKTLESFHQPLPANSILFHFPDGVYSNLTDLPPVETSLQAAGQRATAEGTVLPSSSYDALMRLANLDECVQDALATREKLEAQISSILQQNERSLNVASDAAAAQEKLALTKHYVAMERKRVRTAVRRKEELIASIKARKEAMEQGRSTQEKTRGHLPEAQERLVSSEQLLEQNGEDTKGQVRRIAEDLLTIYPIEPIPDEPLAFTIAGLALPNSTFEDIDREVVAAALGHTAHLVYLLSFYLSVHLPYSINANGSTSFIQDPISASLPQRTYPLYPVSVQYRFEYAVFLLNKDIEYILIKQGLRVLDIRHTLPNLKYLLYVLTSGDSVIPARKAGGVRALVAGRSPPDLSRRGSVDSGASGELVPPRKAWESMSRMNVSLASQRVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q9Z7</accession>
    <name>W6Q9Z7_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Zn(2)-C6 fungal-type DNA-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PROQFM164_S02g002962</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q9Z7"/>
    <dbReference type="STRING" id="1365484.W6Q9Z7"/>
    <dbReference type="OMA" id="LTIHICK"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF82">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="6"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="42"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="58"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM32811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="673" mass="75076" checksum="379B855470473563" modified="2014-04-16" version="1">MSPLASCEPCRKDKVRCDHAQPVCKRCQKRGFTGRCFYHPAPLTSTRRQPDRDGQIHLSPSPSLGNLGNPMSDSETLDAVAPCPSVIQPALRTEQMLPAGYLGPTSFIAGLEESVDLFTHGEQSNTDGRENSAIAPSPALVKRTAEVLRCLQHFPAIKNLVHKYYSVSQTAVIPSPFILNALDELEVTVNGSLFGSASDERLFTFSTFVTHNTSKALQIPQNSDGTVFHKYFTGPFLRLEIIGVICALAGRASYFGLADSTVGDTESPTQFSRKMLVICDLTIHICKSLTALNDLSLWLVHENLLLSKLLRGDSSSVTWNRLGELATGIFEFGAHRDTPSLVPLFILESRRRLFAASYQLDKSIATFLGRPPRISWRHSDCLLPLDISDEDLAGHPHTLEAARRSLDANGWNIKKVYQPASWIRLRFIISTFREEILELSLQKLSPNRTEKLREVSSRCHQAWGLLPEHLQYTSSCWESDLPIGVKLISIISYIAYLYNEFSIQSLLYQDSKRTDSALLDVSSEILSTILTLGRQWERSVDIKGDFTWIALVYGFSCAGVLIRAMQEQARTGQPLLYSGSRSSLIRNLSVFISHLESMAGPEQATSPLFIRATSVFSSIIDGILEPRREVPVNSTNPDTILNSDIETPFLFDLQGMDLFETQDFRVAFDDMLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W6QA56</accession>
    <name>W6QA56_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PROQFM164_S02g003412</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM33260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QA56"/>
    <dbReference type="OMA" id="FIMPNAV"/>
    <dbReference type="OrthoDB" id="440755at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718:SF41">
        <property type="entry name" value="MFS TRANSPORTER OF UNKOWN SPECIFICITY (AFU_ORTHOLOGUE AFUA_5G09940)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="68"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="136"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="196"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="225"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="288"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="326"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="366"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="391"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="420"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="453"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="493"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="67"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM33260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="588" mass="64419" checksum="82A86A64FC32FCBA" modified="2014-04-16" version="1">MSLLHALHYDIKPVASSTVAQELDPTPATPAEHVPDTQVSVEDNLTPRDGQLVFERALPSRTTRSRRVVITALLVLANLVQMTVNFAGIAGGSALSESLGVDDTYASWIAASYALTQGTFVLVSGRLGDVYGHRELVLAGGAWLTICTLASAFCNNFFAFVTMRALAGLGGAFIMPNAVAMISSTNPPGRVRNLSLGLFGASAPVGGYFGALLLGAFLQRTEWKWFFIFIACLGVTTFTPLWALSPREPPADRHGKIDCIGSALGTSSLILFNFVWNQAPSVGWSTPYEIVLLISSIILFGGFLLWERNYAAEPIMPLDIFKAPSFLMLLLVVLLNYMAVGTLIWYQVLWLQKVWHWSPLQFAVGWTPFVICATGAACLAAWMIPRMAAQWILAIGTVTILISNVLMATVPIHQSYWPQIFPSVVLFSFCPDFVYTAGQIIASNSVRRNQQGIAGSVIGTLNLYGNSLGLGFASTIEVQIARRSGSQITGYRAALFFGVAISAVALILDVCFVRLVKDDREGWHEDDRVEEIELTEQAEATVERRSRIYLSSFSRVTTTILYFRPYGPFQHTTSYVVYIFPHIPLDSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>W6QAG1</accession>
    <name>W6QAG1_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peroxisomal targeting signal receptor</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Peroxin-5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">PAY32</name>
        <name evidence="17" type="ORF">PROQFM164_S02g003167</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peroxisomal targeting signal receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM33016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QAG1"/>
    <dbReference type="STRING" id="1365484.W6QAG1"/>
    <dbReference type="OMA" id="WEEQFKQ"/>
    <dbReference type="OrthoDB" id="10006023at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005052">
        <property type="term" value="F:peroxisome matrix targeting signal-1 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016560">
        <property type="term" value="P:protein import into peroxisome matrix, docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000218">
        <property type="entry name" value="Peroxisomal targeting signal receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024111">
        <property type="entry name" value="PEX5/PEX5L"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10130:SF0">
        <property type="entry name" value="GH08708P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10130">
        <property type="entry name" value="PEROXISOMAL TARGETING SIGNAL 1 RECEPTOR PEX5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13414">
        <property type="entry name" value="TPR_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="13" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-0675">Receptor</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="12" id="KW-0882">Thioester bond</keyword>
    <keyword evidence="9 15" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <keyword evidence="10" id="KW-0832">Ubl conjugation</keyword>
    <feature type="repeat" description="TPR" evidence="15">
        <location>
            <begin position="339"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="15">
        <location>
            <begin position="450"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="15">
        <location>
            <begin position="492"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="22"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CDM33016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="634" mass="69998" checksum="44880BF929D5E9CE" modified="2014-04-16" version="1">MSFLGGPECSTAGNPLSQFTKHVQDDKSLQRDRLVGRGPGMQEGMRSHSMMGGQDQMMDDFMQQPGQQLNGPSPQPFAMEHKRRELDKFQTGPARTGSPGWAGEFDSGEQARMEAAFPGQMKNGSGFSPAEFARFQQQSRMGMPQTSSPAAANASPMMAGYQRPMAMGGGYMGGMGMGGMGMMQPMMGGQMGMQQGPMEGQTQDKGKGRMVELDDENWEAQFAEMETATVGNETRTDEEANAAMEAELNDLDRKLAEEDNFEVTDNVHVGDLGDWDGFDSLNSRFRDPQLGDYMFEEDNVYQAVGNPFEEGMKIMRDGGNLSLAALAFEAAVQKDPQHVQAWTMLGSAQAQNEKELPAIRALEQALKVDPGNLDALMGLAVSYTNEGYDSTAYRTLERWLSHKYPTIIDPKEVSGDSDLGFTDRQLLHDRVTELFIQAAQLSPSGAQMDPDVQVGLGVLFYCAEEYEKAVDCFSAALASTESGSTNQQEQLHLLWNRLGATLANSGRSEEAIEAYEQALNINPNFVRARYNLGVSCINIGCYPEAAQHLLGALSMHRVVEQEGRERAREIISDGVHPDGLDDERLERMLHISQNQSTNLYDTLRRVFSQMGRRDLADQVVAGMDVNIFRKEFEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W6QAZ0</accession>
    <name>W6QAZ0_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">D-xylulose reductase</fullName>
            <ecNumber evidence="7">1.1.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Xylitol dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PROQFM164_S02g001444</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Xylitol dehydrogenase which catalyzes the conversion of xylitol to D-xylulose. Xylose is a major component of hemicelluloses such as xylan. Most fungi utilize D-xylose via three enzymatic reactions, xylose reductase (XR), xylitol dehydrogenase (XDH), and xylulokinase, to form xylulose 5-phosphate, which enters pentose phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>xylitol + NAD(+) = D-xylulose + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20433"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17140"/>
            <dbReference type="ChEBI" id="CHEBI:17151"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 or 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Carbohydrate degradation; L-arabinose degradation via L-arabinitol; D-xylulose 5-phosphate from L-arabinose (fungal route): step 4/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.9" evidence="7"/>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QAZ0"/>
    <dbReference type="STRING" id="1365484.W6QAZ0"/>
    <dbReference type="OMA" id="GQICDKE"/>
    <dbReference type="OrthoDB" id="3941538at2759"/>
    <dbReference type="UniPathway" id="UPA00146">
        <property type="reaction ID" value="UER00577"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046526">
        <property type="term" value="F:D-xylulose reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003939">
        <property type="term" value="F:L-iditol 2-dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042732">
        <property type="term" value="P:D-xylose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019569">
        <property type="term" value="P:L-arabinose catabolic process to D-xylulose 5-phosphate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006062">
        <property type="term" value="P:sorbitol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05285">
        <property type="entry name" value="sorbitol_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000068">
        <property type="entry name" value="Sorbitol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045306">
        <property type="entry name" value="SDH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161:SF3">
        <property type="entry name" value="D-XYLULOSE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 7" id="KW-0520">NAD</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0859">Xylose metabolism</keyword>
    <keyword evidence="3 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="8">
        <location>
            <begin position="19"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU369026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM31294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="368" mass="38667" checksum="A501CA7B587EE0C2" modified="2014-04-16" version="1">MTVTEAAQATNEAFVLHPGGTFAFEERSVPTIQSDRDVIVRVMATGLCGSDVHYWQHGRIGPYVVEGPIILGHESTGIVVETGSGAQGFSVGDRVALEPGIACNTCNHCRNGRYNLCRGMRFAATPPYDGTLATYYRVPAECCFKLPSHISMRDGTLIEPLSVAVHSCQLAGFMQDKSVVIFGAGPVGLLCCAVARAFGASTVIVVDVVPARLASAMKYGATHTYQMSMEAADKNAADLLATAGLHDGVDVALDATGAEPCLNCGIIALTQGGTFVQVGLGKPNPSVPVGLICDKEIVFKGSFRYGPGDFKLAVGLLNSRRVNLDGLVTNEYAFGQAEDAFKNVAGRGGIKSVIYGPNVDQEEAKATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W6QBD3</accession>
    <name>W6QBD3_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Bactericidal permeability-increasing protein, alpha/beta domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S01g000811</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QBD3"/>
    <dbReference type="STRING" id="1365484.W6QBD3"/>
    <dbReference type="OMA" id="PRYEDDT"/>
    <dbReference type="OrthoDB" id="5407957at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.10.10">
        <property type="entry name" value="Bactericidal permeability-increasing protein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017943">
        <property type="entry name" value="Bactericidal_perm-incr_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045967">
        <property type="entry name" value="HAM1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31138">
        <property type="entry name" value="CHROMOSOME 19, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31138:SF4">
        <property type="entry name" value="DUF5923 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19343">
        <property type="entry name" value="HAM1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55394">
        <property type="entry name" value="Bactericidal permeability-increasing protein, BPI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HAM1-like N-terminal" evidence="2">
        <location>
            <begin position="204"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM27002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="732" mass="83216" checksum="CD03F34E1351F13A" modified="2014-04-16" version="1">MPSETEPLLPRYEDDTSRQRHLHQKLHSYQIVRAISEGYMPTTEQTIANLRTLLASDVLNLRNQDIGSDGRQLVRDSRLWIQVFIEFLQQKNSQDQLQEFLWRLARSRVEVDRDRLSRQAAHVKARADTKAAYDSFRTVAGLLLTNADFRLFVDDVVTVGRQIFADTTESLAESSKLVAEQVKPSEEEEQALQGPGADEGHALSKAEVEEEVAHVADVTSKGIAQTTHDAVQSAKEHMSGRERDTLLFRLKQAVQKLRERTDYSDSVATLAQLVSRYAKIYADVAEDTASLAQEDLEFNADLKRAVDEFWILLRSFGSAEEWDRLQEKFHNVLRHANKDPEFDDLLGEVGTSLQEMLTNPEFFDSAPQKLDKLKQHSDKIGSETGLRKDVDEFLAQTKRTLRTVPEDPAVSKLINATKKVYHGAWGAYNNKKADLPAELVNVFLPVLLRAIQYIPIPRLEISAPEMDLLLENLVLEPGHTVNFSSFLPYRMHLLTRNDIDVVKTHSKRTETLMKTAFTVTVQGLNISAEDFGYWFRTHTGFFHLKDEGIASFFLDRRGIDISLDIEVGRGRLEQIFSLRGVRVCIHKLDYTVKRSKWRFLLWLTKPLLKHLVRRVLEKKIAEEIVAATFALNRELVFARERLRAARIANPHDLATFVRAVLARLKPADSDVEARIGLEPLNKGVFRGVYAPGSIVKTWNEEATGAQEAIENGDETHGLGHTWRNDIFNVSGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W6QBX1</accession>
    <name>W6QBX1_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Carboxypeptidase</fullName>
            <ecNumber evidence="7">3.4.16.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">pepF</name>
        <name evidence="8" type="ORF">PROQFM164_S03g000280</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase S10 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.-" evidence="7"/>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QBX1"/>
    <dbReference type="STRING" id="1365484.W6QBX1"/>
    <dbReference type="MEROPS" id="S10.006"/>
    <dbReference type="OMA" id="FDIGEMY"/>
    <dbReference type="OrthoDB" id="443318at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000118">
        <property type="entry name" value="Carboxypeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033124">
        <property type="entry name" value="Ser_caboxypep_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018202">
        <property type="entry name" value="Ser_caboxypep_ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF479">
        <property type="entry name" value="CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00560">
        <property type="entry name" value="CARBOXYPEPT_SER_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00131">
        <property type="entry name" value="CARBOXYPEPT_SER_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7 8" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005151061" description="Carboxypeptidase" evidence="7">
        <location>
            <begin position="18"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM33556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="532" mass="59816" checksum="2748D24F7ABE1FE3" modified="2014-04-16" version="1">MLLKSVLSSALLALSLGSDLAAASKHGRFAEIARAPQEKAKRAVEARNQKHAKSDKDYRFLSKKTKHYLVDSLPDVSFDIGEMYSGLVPIDMNNSSRSLFFIFQPTINEPVDEVTIWLNGGPGCSSMESFLQETGRFIWQPGTFAPVENPYAWVNLTNVLWVDQPIGTGYSVGTPTAVSQEETAEDFVKFFKNFQKIFGIKNFKIYVTGESYAGRYVPYISAAMLDEKDKEYFDLDGALAYDPCIGQFDSVQEEVPVVPFVQQNANLFNFNESFMAELEKKHKSCGYEEFIDKYLTFPPPKVQPPMLSSSLADDCDLFDLVYDEIFHINPCFNLYEINQMCPLLWDVLAFPTSLDYQAPGASVYFDRADVKRALHAPNETWSGCSLEPVYVGGDSGPEQEGDISANPIEHVLPQVIEATNRVLIANGDFDMVIITNGTLLAIQNMTWNGHLGFQKKPHTPIDIKIPDLLYADVFAENGASSLDGSQGIMGVQHYERGLMWAQSYQAGHMQPQYQPRVAYRHLEWLLRRTEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W6QCX4</accession>
    <name>W6QCX4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S03</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S03g001272</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QCX4"/>
    <dbReference type="OrthoDB" id="4357512at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM34548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="67" mass="7219" checksum="D71E6BAF5CA573E0" modified="2014-04-16" version="1">MGEAVRSALVNAEQQHEERVKLLKQTHLGELTAVKVDYEGKLTKVTAGSKAETALSQQREVGEGAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W6QE60</accession>
    <name>W6QE60_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S03</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S03g001472</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QE60"/>
    <dbReference type="OMA" id="CMKDIED"/>
    <dbReference type="OrthoDB" id="3891782at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="259"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM34745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="481" mass="54305" checksum="D2D0D5C73485308E" modified="2014-04-16" version="1">MTTRSSNPLWVLQKTVLVYTPDFKACCSARLRIAHDKTANRGSISLRFTAELANLSGRSQVLTLNIPPEIVEKCELARISNVGLCSSDLLPKLPAPVTNLSAVSTLSLILNKTGRFLCPSGVESLSPANQEDLDLDAFAKICQSTSLRLHFSKRQFVEKELNQLEFFSGALRSLQAEHFDYARHGVVQKDWPFSLLLDPPPYSEERVSDRVKQVDPPLYSEQSEQAVGKRPRDLWSMSPDDERRKRLLLTSPEPLGSPTEVNTPSTTHSPSASIRPTYFTHTSSPGRTKRNRLARLEDELRGASDDWIRQLLIRLGREHLLATPQDVDSDRPSESEKVRFANVGMMESHLKQYVDEMIERRLKSHIVDEIVDRAVSECREQIFDECKMHEAGLGEKVDDANSEIHNTANECMKEIEAQAQKHMGDIEEHAQQYMNDIEDQGVEIEMSAEKNAAKLKRWFNSAQSLLDSKSEPGTKARRISI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W6QEB9</accession>
    <name>W6QEB9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Probable 26S proteasome regulatory subunit rpn6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpn6</name>
        <name evidence="5" type="ORF">PROQFM164_S03g001810</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit S9 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM35083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QEB9"/>
    <dbReference type="STRING" id="1365484.W6QEB9"/>
    <dbReference type="OMA" id="ESKIYHA"/>
    <dbReference type="OrthoDB" id="1418352at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.570:FF:000010">
        <property type="entry name" value="26S proteasome regulatory subunit RPN6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050871">
        <property type="entry name" value="26S_Proteasome/COP9_Components"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040780">
        <property type="entry name" value="Rpn6_C_helix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040773">
        <property type="entry name" value="Rpn6_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10678">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 11/COP9 SIGNALOSOME COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18503">
        <property type="entry name" value="RPN6_C_helix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18055">
        <property type="entry name" value="RPN6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00753">
        <property type="entry name" value="PAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="4">
        <location>
            <begin position="222"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="10"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDM35083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="422" mass="47427" checksum="7EF3D83A4F4A21A9" modified="2014-04-16" version="1">MSSKVSPRIQEVRDLVKEDPSKAATSYQKILSEGPGSTEASSRDYEHALIGLGELHRDAKKPQEIADLIKTSRDTFSSFAKAKTAKLVRQLLDLISEIPNTLELQGNVIQSCIEWAISERRSFLRQALEARLVAIYMQKQSYYDALTLINSLLRELKRLDDKLMLVEVQLLESRVYHALGNQAKARAALTAARTSAASVYTPPNLQAGLDMQSGMLHAEDKDFTTSYSYFIEALEGYSSLDESDLATATLQYMLLCKIMLNLVDDVTQLQGSKQAQKYASPRLEAMKAVARAHANRSLEEYEKALSDYRFELGSDVFIRNHLRRLYDAMLEQNLIKVIEPFSRVELDHIAKMVGLDTQQVERKLSQMILDKVIIGVLDQGSGCLIVYDETERDQAYDAALETIEKLGNVVEGLYTNQASLLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W6QEC3</accession>
    <name>W6QEC3_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ankyrin repeat-containing domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g001748</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QEC3"/>
    <dbReference type="STRING" id="1365484.W6QEC3"/>
    <dbReference type="OrthoDB" id="426293at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM27937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="153" mass="17410" checksum="6CAD0C275C0135A2" modified="2014-04-16" version="1">MDPGFSYHDADLTMWFLAHGANPNQRCGKDRTTLSTAFQVASFEIIQKLLEHGVDVFQGQVLHYAARRRLDDRLQVLDFLLEKGLPINNIMFLYSDDYYANMFDGIGTPLHYAADAGLLDLSNIWLREERQQESEIPQDESLSTGPNSTTTRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W6QF04</accession>
    <name>W6QF04_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ubiquitin-like 1-activating enzyme E1A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PROQFM164_S01g001973</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein sumoylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ubiquitin-activating E1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QF04"/>
    <dbReference type="STRING" id="1365484.W6QF04"/>
    <dbReference type="OMA" id="EFFGQFD"/>
    <dbReference type="OrthoDB" id="1708823at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031510">
        <property type="term" value="C:SUMO activating enzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019948">
        <property type="term" value="F:SUMO activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01492">
        <property type="entry name" value="Aos1_SUMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000011">
        <property type="entry name" value="UBQ/SUMO-activ_enz_E1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF162">
        <property type="entry name" value="SUMO-ACTIVATING ENZYME SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01849">
        <property type="entry name" value="UBIQUITINACT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="7">
        <location>
            <begin position="19"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM28162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="388" mass="43267" checksum="DBB20C89C9A29211" modified="2014-04-16" version="1">MAEQQDNTQAISADEIALYDRQIRLWGVHAQEKIRSANILLITVKALANEVAKNLVLAGIGSLTILDHQDVTEEDLGAQFFIAAAQSEQDVIGKNRAQVAGPQIHKMNPRVKLNIDTSDVSTKAPEFFAQFDITIATELDFVTNITVNAACRLANRPFYAAGLHGFYGYVFADLISHDFVIERSKSNMAPATQETPTRSIIDITTKKEENNANKKEPSKIIELVTKREVYSPLILANTSPLPEEYTRLARRRKQVTPLLSCLRALWEFEKLRGHRPTFTHEDLELFTKLSRDRHQELKLDPLTLDSVFLRTFLQNLGSELSPVAAFLGGALAQDVINVLSAREQPLQNMLLFDGEKSVGPIYSLHPFFPDVGALDMAAVPPGRITVDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W6QF34</accession>
    <name>W6QF34_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PROQFM164_S01g002013</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QF34"/>
    <dbReference type="STRING" id="1365484.W6QF34"/>
    <dbReference type="OrthoDB" id="4369119at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF68">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01120)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="14"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="1"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM28202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="157" mass="16664" checksum="516B20A65689F3AA" modified="2014-04-16" version="1">MILAPLSELYGRNIIYHVCNVLCLLMTITCALAPNLLGFMVCRLLAGTAGSVPLSIGAGSLADMIPSKNRGLAMGARSCAWTRDSAHSGRIFGRVSKAFDAGANGYCRGEGVGVVVLKTLPQALADGNEVLGCLYDVRRGFREEASERHPSLSPCHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W6QFG0</accession>
    <name>W6QFG0_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Delta(24(24(1)))-sterol reductase</fullName>
            <ecNumber evidence="16">1.3.1.71</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">ERG4</name>
        <name evidence="20" type="ORF">PROQFM164_S04g000424</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>ergosterol + NADP(+) = ergosta-5,7,22,24(28)-tetraen-3beta-ol + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16933"/>
            <dbReference type="ChEBI" id="CHEBI:18249"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.3.1.71"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="17">
            <dbReference type="Rhea" id="RHEA:18503"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="15">Steroid metabolism; ergosterol biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 18">Belongs to the ERG4/ERG24 family.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.71" evidence="16"/>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QFG0"/>
    <dbReference type="STRING" id="1365484.W6QFG0"/>
    <dbReference type="OMA" id="QLPYFCN"/>
    <dbReference type="OrthoDB" id="5326588at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000246">
        <property type="term" value="F:Delta24(24-1) sterol reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1630:FF:000003">
        <property type="entry name" value="C-24(28) sterol reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001171">
        <property type="entry name" value="ERG24_DHCR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018083">
        <property type="entry name" value="Sterol_reductase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21257">
        <property type="entry name" value="DELTA(14)-STEROL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21257:SF48">
        <property type="entry name" value="STEROL REDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01222">
        <property type="entry name" value="ERG4_ERG24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01017">
        <property type="entry name" value="STEROL_REDUCT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3 18" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11 18" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="9 18" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 18" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="14 18" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="10 18" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="13 18" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="4 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="211"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="246"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="303"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="328"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="368"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="404"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="484"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="38"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00029435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00038892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU369120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CDM35543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="547" mass="62857" checksum="6C74C3B2AAA77D02" modified="2014-04-16" version="1">MTLTRSQTGKTPKKMDRPGFVETPGGRRATRNSSVLGSSENEASLSPSPSLSRSKSASRRRAAVKIKTEEDDTPVKVTPNGKTTDTKPESPSRVIDGWEEGLDPKVDYSGHFEFGGSLGVLSMMIGFPMLMYYMWIGATYYNGKFPRPAENESYGDFFAHLVDLIYTGAFPSVKAWTIYWVFFIFEGACYVLLPGVSVSGRPLPHMGGKQLPYYCSGVWSFYTSIALALIAHVTGVFKLYTIIDEFGPLLTVAILSGYIVSFIAYFSALARGAEHRMTGYPIYDFFMGAELNPRMFKILDFKMFFEVRLPWYILLGLSMGAAARQWEMYGYVSGEVMFLVMAHYLYANACSKGEECIVSTWDMYYEKWGFMLIFWNLAGVPLSYCHCTIYLANHDPAEYRWNRYFLAFLFVAYLFVYWVWDTTNSQKNRFRQQERGTIVTRNTFPQLPWQTVENPKTLTAADGSKILIDGWYGKARKIHYTCDLYFALNWGLITGFSSPFPWFYPVFFACMISHRALRDIQRCRTKYGETWLEYERQVPYLFIPYLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W6QFP5</accession>
    <name>W6QFP5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S02g003155</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM33004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QFP5"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM33004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="82" mass="8744" checksum="29C51C70C27A94B4" modified="2014-04-16" version="1">MKNGFLDGLAGTGEPSGSCSSGVTAEESRKSSRGQGSRISWRRTPGELSDQCAEPPNEGENAQGRAECVSQVSKLFRDRDHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W6QFZ9</accession>
    <name>W6QFZ9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NAD(P)-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S03g001618</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QFZ9"/>
    <dbReference type="STRING" id="1365484.W6QFZ9"/>
    <dbReference type="OMA" id="AMGKYDK"/>
    <dbReference type="OrthoDB" id="9975943at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14097:SF8">
        <property type="entry name" value="NAD(P)-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14097">
        <property type="entry name" value="OXIDOREDUCTASE HTATIP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM34891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="254" mass="27343" checksum="795EEAE89A334951" modified="2014-04-16" version="1">MHLILTGATGLVGSSVLDAMLKNAAVSKISILSRSPVRMAEDAKDPRVHVITHTDFESYKPELLNQLKDADGCVWALGISQTKVTKEQYVKITKDYTLAAANAFSTIKPSNHPFRFIHVSGEGATQTPGRFSPIFARVKGETEALLGTLSEQNPTFRVDSVRPAFVDPATHDAIKPYIPSGATAGVVANLGVALLGPGIRCFMKSMHSPTEQLGSFLTEMAMGRYEAKLEGPGVFRLGGGYVIENIGMRRILGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W6QG50</accession>
    <name>W6QG50_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 13">Tryptophan synthase</fullName>
            <ecNumber evidence="5 13">4.2.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">trp-3</name>
        <name evidence="15" type="ORF">PROQFM164_S04g000266</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + L-serine = D-glyceraldehyde 3-phosphate + L-tryptophan + H2O</text>
            <dbReference type="Rhea" id="RHEA:10532"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.2.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 5/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the TrpB family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the N-terminal section; belongs to the TrpA family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.20" evidence="5 13"/>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QG50"/>
    <dbReference type="STRING" id="1365484.W6QG50"/>
    <dbReference type="OMA" id="VDTARHS"/>
    <dbReference type="OrthoDB" id="10050244at2759"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00044"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004834">
        <property type="term" value="F:tryptophan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd06446">
        <property type="entry name" value="Trp-synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04724">
        <property type="entry name" value="Tryptophan_synthase_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000151">
        <property type="entry name" value="Tryptophan synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000001">
        <property type="entry name" value="Tryptophan synthase beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000004">
        <property type="entry name" value="Tryptophan synthase beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00131">
        <property type="entry name" value="Trp_synth_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00133">
        <property type="entry name" value="Trp_synth_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006653">
        <property type="entry name" value="Trp_synth_b_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006654">
        <property type="entry name" value="Trp_synth_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023026">
        <property type="entry name" value="Trp_synth_beta/beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018204">
        <property type="entry name" value="Trp_synthase_alpha_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002028">
        <property type="entry name" value="Trp_synthase_suA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00262">
        <property type="entry name" value="trpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00263">
        <property type="entry name" value="trpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48077:SF3">
        <property type="entry name" value="TRYPTOPHAN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48077">
        <property type="entry name" value="TRYPTOPHAN SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00290">
        <property type="entry name" value="Trp_syntA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00167">
        <property type="entry name" value="TRP_SYNTHASE_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00168">
        <property type="entry name" value="TRP_SYNTHASE_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10 13" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="11 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="9 13" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 13" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="14">
        <location>
            <begin position="374"/>
            <end position="697"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CDM35385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="723" mass="77476" checksum="243074C50C345729" modified="2014-04-16" version="1">MEAIKQTFAKCKAQNRAALVAYITAGYPTVEEAVDILLGLENGGADIIELGIPFTDPIADGPTIQTANTKALENGVTLTTVLELVRTARSRGLQTPLMLMGYFNPVLKYGEERMLRDCKEAGVNGFIMVDLPPEEAVRFRDLCSSAGLSYVPLIAPATSDARMRLLCKIADSFIYVVSRMGVTGATGSLSANIPELLHRVHEYSGNVPAALGFGVSTREHFLSVQEQAEGVVIGSQIITCVGKAPAGQAAKAAEEYLSSITGRKRERDATGALTHEINVLEAIQKAQPSAQVQPTKVITDSDTPAGPGLADQLEALNVTKDASAQPSRFGEFGGQYVPESLMDCLAELEHGFNIANNDPNFWEEFRSYYPYMGRPSSLHMAQRLTDHVGGANIWLKREDLNHTGSHKINNALGQILIARRLGKTRIIAETGAGQHGVATATVCAKFGMQCTVFMGAEDVRRQGLNVFRMKLLGASVIAVEAGSRTLRDAVNEALRAWVVELDTTHYIIGSAIGPHPFPTIVRTFQSVIGNETKEQMQAQIGKLPDAVIACVGGGSNAVGMFYPFSNDPSVKLIGVEAAGDGIDTNRHSATLSGGSHGVLHGVRTYVLQNEHGQISDTHSISAGLDYPGVGPELSNWKDTNRATFIAADDSQALAGFRALAQHEGIIPALESSHAVWGVMQVAKTMGKGQNIVLNLSGRGDKDVQQVADELPRLGPKIGWDLRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W6QG85</accession>
    <name>W6QG85_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">glucan endo-1,6-beta-glucosidase</fullName>
            <ecNumber evidence="8">3.2.1.75</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PROQFM164_S04g000694</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>Random hydrolysis of (1-&gt;6)-linkages in (1-&gt;6)-beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.75"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the glycosyl hydrolase 30 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.75" evidence="8"/>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QG85"/>
    <dbReference type="STRING" id="1365484.W6QG85"/>
    <dbReference type="OMA" id="FGGIAWH"/>
    <dbReference type="OrthoDB" id="2160638at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046557">
        <property type="term" value="F:glucan endo-1,6-beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004348">
        <property type="term" value="F:glucosylceramidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006680">
        <property type="term" value="P:glucosylceramide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000128">
        <property type="entry name" value="Endo-1,6-beta-D-glucanase neg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033452">
        <property type="entry name" value="GH30_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001139">
        <property type="entry name" value="Glyco_hydro_30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033453">
        <property type="entry name" value="Glyco_hydro_30_TIM-barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11069">
        <property type="entry name" value="GLUCOSYLCERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11069:SF23">
        <property type="entry name" value="LYSOSOMAL ACID GLUCOSYLCERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02055">
        <property type="entry name" value="Glyco_hydro_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17189">
        <property type="entry name" value="Glyco_hydro_30C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004880201" description="glucan endo-1,6-beta-glucosidase" evidence="10">
        <location>
            <begin position="18"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 30 TIM-barrel" evidence="11">
        <location>
            <begin position="73"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 30 beta sandwich" evidence="12">
        <location>
            <begin position="430"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00036633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF17189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDM35813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="488" mass="51465" checksum="E8F8DA22744D6B9B" modified="2014-04-16" version="1">MLPSFLPLLLLSVLAEASPGKRATTASAYCSNSNGNYKLSSISAPVQGSGSPGSESTWQLTVDDTSSGHKQTIVGFGAAVTDATVTSFNTLSSSTLEQLLNELMTGAGAGFALMRHTIGASDLSGDPAYTYDDNGNNADPSMSGFNLGDRGSAMATMLAKMKSLQSNLKTLGSPWSAPGWMKLNGVIDGATNNNNLNDGYLTSGGTGSTGYASAFAQYFVKYIQAYANLGAHIDAITIQNEPLNSQAGYPTMYVFDYESAQLIQNYVGPALAQAGLSTDIWAYDHNTDVPSYPQTVINGASQYVHGVAWHCYASNVDWTVLTQFHETKPNVNQYMTECWTPASAAWNQAADFTMGPLQNWASGVTAWTLGTNDQDGPHLSSGGCATCQGLVTIANGGYTFNPAYYMMAQFSKFMPPGAIVLSGTGSYTYSNGGGVQSVASLNPDGTRTVVIENTFSNDIYILLSTNSGQEWSGNVPSQSVTTWVLPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W6QGC6</accession>
    <name>W6QGC6_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Peptidase M20</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PROQFM164_S03g001753</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M20A family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM35026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QGC6"/>
    <dbReference type="STRING" id="1365484.W6QGC6"/>
    <dbReference type="OMA" id="RLHKGVM"/>
    <dbReference type="OrthoDB" id="3064516at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05652">
        <property type="entry name" value="M20_ArgE_DapE-like_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001261">
        <property type="entry name" value="ArgE/DapE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050072">
        <property type="entry name" value="Peptidase_M20A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43808">
        <property type="entry name" value="ACETYLORNITHINE DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43808:SF8">
        <property type="entry name" value="PEPTIDASE M20 DIMERISATION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="Bacterial exopeptidase dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00758">
        <property type="entry name" value="ARGE_DAPE_CPG2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00759">
        <property type="entry name" value="ARGE_DAPE_CPG2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="7">
        <location>
            <begin position="231"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM35026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="439" mass="46245" checksum="6F255E51E018D67C" modified="2014-04-16" version="1">MKLSSYLAAAAIISGVQASPHPALQQQLLGVPSSSQPSYSQAGLDDIISSSPLLSFHRDLVEIESLSGNEHDVGLFVAQFLEARNFTVVKQEVPPVKDQEKTKTRYNIYAVPKSYTQPPSILLTSHIDTVPPFIPYSVHQPISDSTTFDPENLIIAGRGSVDAKGSVAAQIFATLETLASQPDAKLGLLFVVGEEIGGDGMKLFSDSSLNAKSAINTIIFGEPTEAALVAGHKGMLGFKVLAHGSAAHSGYPWLGKSAVSAILPALSRVDVLGDIPTEEGGLPASPKYGPTTLNIGVIRAGVATNVVPSEAWADVAVRLAAGTPAEAGEIIQRAVEEAVRGFEAEVVVDFVSHGESYPPQDLDVDVDGFDVTTVNYGTDVPNLAVGPGVKRYLYGPGSIFVAHGDNEALTVRQIKEAVVGYKKLIEAALEREAKGEVVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>W6QGM0</accession>
    <name>W6QGM0_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ATP-dependent DNA helicase II subunit 1</fullName>
            <ecNumber evidence="5">3.6.4.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">ATP-dependent DNA helicase II subunit Ku70</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="primary">ku70</name>
        <name evidence="24" type="ORF">PROQFM164_S04g000859</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Single-stranded DNA-dependent ATP-dependent helicase. Involved in non-homologous end joining (NHEJ) DNA double strand break repair. DNA-binding is sequence-independent but has a high affinity to nicks in double-stranded DNA and to the ends of duplex DNA. Binds to naturally occurring chromosomal ends, and therefore provides chromosomal end protection. Required also for telomere recombination to repair telomeric ends in the absence of telomerase. KU70, of the KU70/KU80 heterodimer, binds to the stem loop of TLC1, the RNA component of telomerase. Involved in telomere maintenance. Interacts with telomeric repeats and subtelomeric sequences thereby controlling telomere length and protecting against subtelomeric rearrangement. Maintains telomeric chromatin, which is involved in silencing the expression of genes located at the telomere. Required for mating-type switching.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Heterodimer of Ku70 and Ku80.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ku70 family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="5"/>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QGM0"/>
    <dbReference type="STRING" id="1365484.W6QGM0"/>
    <dbReference type="OMA" id="FWANVKH"/>
    <dbReference type="OrthoDB" id="3249161at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043564">
        <property type="term" value="C:Ku70:Ku80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00788">
        <property type="entry name" value="KU70"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="vWA_ku"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ATP-dependent DNA helicase II subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ATP-dependent DNA helicase II subunit 1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="X-ray repair cross complementing 6"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.970.10">
        <property type="entry name" value="Ku70, bridge and pillars"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.30">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006164">
        <property type="entry name" value="DNA_bd_Ku70/Ku80"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006165">
        <property type="entry name" value="Ku70"/>
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    <dbReference type="InterPro" id="IPR027388">
        <property type="entry name" value="Ku70_bridge/pillars_dom_sf"/>
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        <property type="entry name" value="KU70_core_dom"/>
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        <property type="entry name" value="Ku_C"/>
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        <property type="entry name" value="Ku_N"/>
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        <property type="entry name" value="SAP_dom"/>
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        <property type="entry name" value="SPOC-like_C_dom_sf"/>
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        <property type="entry name" value="vWFA_dom_sf"/>
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        <property type="entry name" value="ku70"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="KU AUTOANTIGEN DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12604:SF2">
        <property type="entry name" value="X-RAY REPAIR CROSS-COMPLEMENTING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ku78"/>
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    </dbReference>
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        <property type="entry name" value="SAP"/>
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    </dbReference>
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        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF100939">
        <property type="entry name" value="SPOC domain-like"/>
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    </dbReference>
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        <property type="entry name" value="vWA-like"/>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0158">Chromosome</keyword>
    <keyword evidence="9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="15" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="16" id="KW-0234">DNA repair</keyword>
    <keyword evidence="14" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11 24" id="KW-0347">Helicase</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-0539">Nucleus</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0779">Telomere</keyword>
    <feature type="domain" description="SAP" evidence="23">
        <location>
            <begin position="615"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="578"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="22">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="22">
        <location>
            <begin position="580"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with DNA; for 5'-deoxyribose-5-phosphate lyase activity" evidence="21">
        <location>
            <position position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00021796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00024890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00031811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PIRSR" id="PIRSR003033-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="CDM35978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="653" mass="73104" checksum="B5CBB1CD95883B6B" modified="2014-04-16" version="1">MAEDYYTREEDNYEDEELDQTSFKSVKDAVLFAIDISSSMLTPRPSPDPKKHGDESPASAALKCAYHLMQQRIVSNPHDMIGVLLYGTKLSKFYDENEDDQEDLSYPHCYLYTDLDVPSAQEVKHLRSLTSPADGDDDVRQILEPSKEPVSMANMLFCANQIFTSKAPNFSSRRLFVVTDNDNPHADNKAMRSAATVRARDLYDLGVNIELFPISQSDHEFDTSKFYDDIIYKTSPSDGDAPAYLQPDTNASTGKGDGLTLLNSLLSSINSRSVPRRSLFSNVPLEIGPDFKISVNGYLLLKKQEPARSCFIWQGGETAQIAQGVTTLMSDETGQEIDKSSIRKAYKFGGEQVSFSIEEQQALRNFGDPVIRIIGFKPLSALPFWANVKHPSFIYPSEEGYIGSTRVFSALHQKLLDSEKLALVWFIPRRNASPVLAAMIAGAEKIDENGVQKIPPGMWIIALPFADDVRQNPDSKINRAGDALNNAMRDVIRQLQLPKAIYDPSKYPNPSLQWHYRILQAIALDEDFPESPDDKTVPKYRQVHKRAGDYILKWAEELNLQASEMFDGSAATSTLVKRGAKTEPASDHPPKRVKIEDSAPGVEDEVKKCFDKGTVSKLTMVVLKEFLHSHGRATAGKKADLVERVEQYFEQKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W6QGN3</accession>
    <name>W6QGN3_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Taurine catabolism dioxygenase TauD/TfdA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S01g002563</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QGN3"/>
    <dbReference type="STRING" id="1365484.W6QGN3"/>
    <dbReference type="OMA" id="ERWDIVY"/>
    <dbReference type="OrthoDB" id="272271at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.130.10:FF:000011">
        <property type="entry name" value="Taurine catabolism dioxygenase TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050411">
        <property type="entry name" value="AlphaKG_dependent_hydroxylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696:SF54">
        <property type="entry name" value="FAMILY OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G13850)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696">
        <property type="entry name" value="GAMMA-BUTYROBETAINE HYDROXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="2">
        <location>
            <begin position="93"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM28752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="402" mass="45666" checksum="964379CD2DA65F24" modified="2014-04-16" version="1">MSAVQTITVATQPDIQYHPDYEKYKERTRRRKETEDLQSTLPAGFPQKLVSSLVWEGKDVEKRDDWVYQLSDDQLDELDAALKSFKSLGLSSGHINQSNFPLPTLRPVLRDLSKEIHTGRGFVVLRGLRIDNYSREDNIIIYAGVSSHIGNIRGRQQEARLADGNSPVISHIKDLTSTTDKKLIGAPSNTSDKQVFHTDAGDIISLLCLNRAAEGGESYLASSWNVYNILAKERPDLIHTLSQDWPVDGFNNPARPYSLRPLLYHQPATATTPERVLIQYARRYFTGFLAQHRSKDIPPITEAQAEALDALHFLAAKHSATLDFQKGDVQYVNNLSIFHARNGFKDEPGKERHLLRLWLRDPENAWETPRELQERWDIVYKDVAADKQVFSLEPTIRKNVGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W6QH02</accession>
    <name>W6QH02_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Membrane protein,Tapt1/CMV receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PROQFM164_S04g000112</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAPT1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QH02"/>
    <dbReference type="OMA" id="TCCVLMY"/>
    <dbReference type="OrthoDB" id="5376140at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008010">
        <property type="entry name" value="Tatp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13317">
        <property type="entry name" value="TRANSMEMBRANE ANTERIOR POSTERIOR TRANSFORMATION PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13317:SF4">
        <property type="entry name" value="TRANSMEMBRANE ANTERIOR POSTERIOR TRANSFORMATION PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05346">
        <property type="entry name" value="DUF747"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="502"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="582"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="889"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="152"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="427"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="925"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="57"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="229"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="427"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="473"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM35231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="1016" mass="113236" checksum="C1FCA5F08421E9FA" modified="2014-04-16" version="1">MAENTVQNGASGNSKSQQQLVPYTVEEKCSRVDTVVQSNGEADERPINGDDGSNEQQTHDTTSERDLTNGAYKIADLESAHGLGILVEHSPNTRDNIGQLSVVDVYDGPKVKATLAESLAELSNDLSHRLSEDKDKVMKLSPEKIQELTSSPESIPYRPMGLERNPGRRVVSDNVHGNAPLARPEIPEVALQSLSERPSPADVLTKLRPTKEVLPGDTSTPASPAFPRNIQNSSLRNRPQPARTLSTPGSTRRQLPLTPSNDRLTQTWALRPKQDRPALERDLKSHLVASPQIVESPKPSPSPSSIPLPPVSLPTYLQLELASGRPSPLYIHRDAANDFPYESSRVKIERLMNFIMLAPMLEQVLCFGSLACLDAWLYSFTIMPLRFIKAVYILGESWVMNLGAEIRFIWKFVLNGIGRVWRRRNHNAKEDHQRGRPESESDATPHLPSGSSAGPDTVPADRDSRQSQSETPRRKHRTSESRKYHHRRKKSMPSALLPDDKADILTGLLMIATCCVLMYFDASRMYHWIRGQAAIKLYVIYNVLEVSDRLLAAIGQDVLECLFSREALERRPDGRSKIIRPFWLFLVALVYTVSHALSLFYQVMTLNVAVNSYSNALITLLLSNQFVEIKSTVFRKFEKENLFQLTCADVVERFQLWLMLTIIASRNIVETGAFNFIGNLGLGSSFPGQSSTITNSTPLSTPPRTASSILPQAFTLFPSSILSSFHSVNSFIPTLAQVLGPFLVVLGSEMLVDWLKHAYINKFNNNRPAIYGRFLDVLAKDYYTNAFGEQNLTRRIGLPVIPLSCLFFRVSVQTYQMFLAALLPQNPSSTAMGATSLASIHNHYVPSPIPSAPPLTLATLIPASAAHVSAFFRTLLENAIPSPAQSVHIFTGILLLTGFIVLLILKLLLGMVLLAFARSRYRKMKGRESERKQSSNNQSGTESGAPRSRDFHVEGSQRVGGWGVVEVGDEKRKLIYADDPDGLRRLKEKEEKDKSKDGEFSVDHVQRYEMIAKKIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W6QH03</accession>
    <name>W6QH03_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Forkhead-associated (FHA) domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S04g000596</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QH03"/>
    <dbReference type="STRING" id="1365484.W6QH03"/>
    <dbReference type="OMA" id="RDRVEIM"/>
    <dbReference type="OrthoDB" id="5348546at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22699">
        <property type="entry name" value="FHA_PLM2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="2">
        <location>
            <begin position="105"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="300"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="346"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="47"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="365"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="378"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM35715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="515" mass="57444" checksum="0A0369DFA2749979" modified="2014-04-16" version="1">MESSPLKSRVGSILGVKRPAALLPAFEPSSSPSLPRPQKRVAREPDVSTYPTPVPTSSTHIMSSSPPRGVAASRPSLSRSFSAALERSPLSAVPAIMLLENGEPILMGRSSVSCHHQLAASRMISRVHVKATYKPAPNPFDRDRVEIVCMGWNGIKIHCQGRKYDLAKGKTFTSDIKDADIMIDVHEARVLVQWPRSERRDCPSTDSEQTSDEATPTQRRQSRREPQESPLLDRQRLASPVSPSPAVQHAIPPSSPIFTPSRSRAAVVVYEDEPSPLKRHNTVTGVISQSARRATAMLHTSRASELSELSRSEEFSDNDEENDPIIHSFGPFGENLLPRMASFRAGDSPVQTTRSPRNLLPAQPLQPTRSPRQPATVQEDREVESTEAKPQYTDERSERVRNHAANQLAFSRLSSTPFSTIVNNLPPAYWKSGHEYPTGLSRSDIRNILESTKFIGRVAREGKDAAGKPLESEYYYVPDEDDDTMRRSAVVDDLRKPGLRNCRKQHKQYFWRKPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W6QIJ4</accession>
    <name>W6QIJ4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase M20</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S05g000471</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20A family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QIJ4"/>
    <dbReference type="STRING" id="1365484.W6QIJ4"/>
    <dbReference type="OMA" id="CSSGVWA"/>
    <dbReference type="OrthoDB" id="4676at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016813">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03884">
        <property type="entry name" value="M20_bAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010158">
        <property type="entry name" value="Amidase_Cbmase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01879">
        <property type="entry name" value="hydantase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32494">
        <property type="entry name" value="ALLANTOATE DEIMINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32494:SF20">
        <property type="entry name" value="PEPTIDASE M20 DIMERISATION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001235">
        <property type="entry name" value="Amidase_carbamoylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="Bacterial exopeptidase dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM36638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="462" mass="50614" checksum="6DCA948E6268F782" modified="2014-04-16" version="1">MYGTKGATRALHSNTRRFTTTTRLQAPSGLKINPERLWNTLHETCKWGAEHRYGENPTDTGMARLTLNDDDARVRRWFAAEVQKLGCSLSVDQMGNMFGRQSGRLNSAAPMTAMGSHLDTQPRGGRYDGILGIMAALEILRTIKESGFQTNYDIGVVNWTNEEGARFPKSMCSSGVWAGAIPIQKAWDLRDIHDPRVTLRSELERHGYLGEIACSSDPVTGYPLGAHFELHIEQGPILPGNNRSIGVVRGAQGYRWLTMTVHGKDAHTGTTPFSDRQDPLLASSRMIAASHDIAMRHNALASTGIIRVPSNASTNTVSSQVTFTLDIRHPQDSVVHAVQDECLQAFEAIALQDGKGVSFDWTLDTDSPAVEFDDNCVASVQAAADQLVGREKSMLMTSGAGHDTVYTSKRCPSAMIFVPCRDGVSHHPTEYCSPQDCALGTQALLEAVVHYDQFRIEAEGQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W6QIY0</accession>
    <name>W6QIY0_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Conserved oligomeric Golgi complex subunit 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Component of oligomeric Golgi complex 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PROQFM164_S05g000193</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COG4 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QIY0"/>
    <dbReference type="STRING" id="1365484.W6QIY0"/>
    <dbReference type="OMA" id="RASECQQ"/>
    <dbReference type="OrthoDB" id="47059at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048682">
        <property type="entry name" value="COG4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048684">
        <property type="entry name" value="COG4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013167">
        <property type="entry name" value="COG4_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048680">
        <property type="entry name" value="COG4_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24016">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24016:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20662">
        <property type="entry name" value="COG4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08318">
        <property type="entry name" value="COG4_m"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20663">
        <property type="entry name" value="COG4_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00762">
        <property type="entry name" value="Cog4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="COG4 transport protein middle alpha-helical bundle" evidence="10">
        <location>
            <begin position="226"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="36"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="386"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDM36360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="843" mass="93041" checksum="80C98F56434B747F" modified="2014-04-16" version="1">MNHEAVKPALTARNPLQLAWHQQTNLRRPMAPRMAATANGHNSMPKSPPNTNASPKETSPLAQPDIFNASSVAEIKATLSHLHTQEASVTARLDALVTSQKDLSRELGRLDLMRVNIGTHASTTRSISHGMLFEAAGTADRISSAVRRLDLEQARVKATLEVVEQVAELKACTLGVAGSMGAPQDWEKAASYLHRAAQIPATVVNGAFAAEMVPTAEVPDPPSVTLDNAAESLCGLFLREFEKAVKENDGAKITRFFKLFPLIGRSEVGLDVYGRYVCQGVAAKARANLNGATGNAQNKDGFFYANALTKLFEHIAQIIDGHGGLVEHHYGPRKMGRVIERLQVEADVQGGIILDTWSDERHVDRKLMDIKSYAFTFLVQSFLSAQRTGPPRPQSPAMGASTATDEEGVDMKEIDGVLNEMAIMLGRWSLYCRFLADTCNSSEDEPDDDKRFELPTFLRESPLAQKINDRLVAPFNTMTTFFFRRSVEKAFQLDESPSGLTMNPQRPLKADPPHITSAIDDIMYIVNKVIQQSLATSQEAVVTNVVPTLSRVLGSDFIGMTQRKMRDECYPRIPVHGGPPSEQTIISFLVQMNNLDLGVDYIRRIVQNNTGSKPTDTDTTTQATPHLLSIFPSPSTAQKVLQTLQTLSTTFESKVTDLLTDGIQVIFNNAIKPRLRPILADSFRDIEYTPNPNLEPDNPNSPFDKELVKPRFTAAWNDLLTPFARILTPSAFDRVLGVTLAYLARLLEKRLWSYGSRINALGAARLERDVAGLVGAAVEVGYVAGAPGRYRYRECFARCVQMTLVMGMDEDEWDEVRRGGVAAEVVEKLGREDLIRVRGMVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W6QIZ9</accession>
    <name>W6QIZ9_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ER membrane protein complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PROQFM164_S01g003379</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FM164</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Component of the ER membrane protein complex (EMC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EMC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QIZ9"/>
    <dbReference type="STRING" id="1365484.W6QIZ9"/>
    <dbReference type="OMA" id="SWAEVYH"/>
    <dbReference type="OrthoDB" id="28092at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058545">
        <property type="entry name" value="Beta-prop_EMC1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026895">
        <property type="entry name" value="EMC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011678">
        <property type="entry name" value="EMC1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018391">
        <property type="entry name" value="PQQ_b-propeller_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21573">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21573:SF0">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25293">
        <property type="entry name" value="Beta-prop_EMC1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07774">
        <property type="entry name" value="EMC1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00564">
        <property type="entry name" value="PQQ"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0732">Signal</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004880256" description="ER membrane protein complex subunit 1" evidence="12">
        <location>
            <begin position="19"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="919"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="domain" description="EMC1 first beta-propeller" evidence="14">
        <location>
            <begin position="18"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="ER membrane protein complex subunit 1 C-terminal" evidence="13">
        <location>
            <begin position="728"/>
            <end position="948"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF07774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF25293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CDM29567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="950" mass="102457" checksum="FEB25627EDD3B2BC" modified="2014-04-16" version="1">MWLQAALFFAACLSPAAAIYSDEVDHIDFHHALLGTPSPDSTFFLKPFTSSNASLIYTISDKLLVGAVNPRDGALVWRQNISRSADSPAHGAGLLRGLDGNDAVVAAVDNYIASWSAQDGKLGWEHRVSEGVVGDLELLELEDATATSGVRDTIAVVASEGNGIVKRLDGNTGKTVWEYKDASGDIPFQVSSSSTEVFYISLHSAMLKGFKIKVTVLDPLTGRQTRHQILNSEADVATPESVLYVGANSASPIIVWADKSQKSLKVNVIGTKEVTSIAIDNTSGSGIRQITVHAPHKLNALPHFLVHFETEAGAWAEVYHVDLVSAKVTKAYRLPYLSGQSAVAVSVIDANVYFTRVTDLEAVVVSSASHGILGRWDLQKPSSDIALHSVSEVVAKGKSVAVRTALFRKYGDWQLIRNGQIEWTRHEGLIDTVAATWAETDAQEDLAHELEVEGHETLYGAYLHRVKRHVRDLEHLPDWLKDLPKRILSSILTDEVSNLDSFGLAKSVIVATKSGRVYALDTGNHGAVSWGIQAVETSDWNVKAMLTSPGVVTIYSDDGGSVTVDVSTGEIVSRIEPSTSKLHSIAVFEIQDGSSLATVGVREDGTPVAAFANEDGFLVTTSIDGRVLGWAAKDNKTPVWEFVPPSGQKVVEATARPAHDPVASIGRVLGNRSVLYKYLNPNLALVTAVNEQTHTASFYLLDGVSGNVIHASTQAGVDSTQPIASAMSENWFAYSFWGDVDGSESSAKGYQLVISELYESPLPNDRGLLDSATNYSSTAILPLPYVISQAFMIPESISHMAVTQTRQGITTRQLLCTLPSSNSIVGIPRPVLDPRRPVDRDPTAAEAEEGLFRYAPYLDFDGKWYLSHTRDVAGINAVLSRPTLLESTSLIFAYGSDIFGTRATPSQAFDILGKSFSKLQLVLTVVALGAGVAVLAPMTRKKQVNALWRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W6QKF6</accession>
    <name>W6QKF6_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ferroxidase</fullName>
            <ecNumber evidence="3">1.16.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PROQFM164_S05g000314</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>4 Fe(2+) + O2 + 4 H(+) = 4 Fe(3+) + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:11148"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.16.3.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the frataxin family.</text>
    </comment>
    <dbReference type="EC" id="1.16.3.1" evidence="3"/>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QKF6"/>
    <dbReference type="STRING" id="1365484.W6QKF6"/>
    <dbReference type="OMA" id="YSEHYFN"/>
    <dbReference type="OrthoDB" id="1897642at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004322">
        <property type="term" value="F:ferroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034986">
        <property type="term" value="F:iron chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.920.10:FF:000004">
        <property type="entry name" value="Mitochondrial chaperone Frataxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.920.10">
        <property type="entry name" value="Frataxin/CyaY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017789">
        <property type="entry name" value="Frataxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002908">
        <property type="entry name" value="Frataxin/CyaY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036524">
        <property type="entry name" value="Frataxin/CyaY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020895">
        <property type="entry name" value="Frataxin_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03421">
        <property type="entry name" value="FeS_CyaY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03422">
        <property type="entry name" value="mito_frataxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16821">
        <property type="entry name" value="FRATAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16821:SF2">
        <property type="entry name" value="FRATAXIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01491">
        <property type="entry name" value="Frataxin_Cyay"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01219">
        <property type="entry name" value="Frataxin_Cyay"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55387">
        <property type="entry name" value="Frataxin/Nqo15-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01344">
        <property type="entry name" value="FRATAXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50810">
        <property type="entry name" value="FRATAXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0409">Iron storage</keyword>
    <keyword evidence="6" id="KW-0410">Iron transport</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="48"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDM36481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="213" mass="23610" checksum="5A81E8FC14EFE0E9" modified="2014-04-16" version="1">MLSRTAPRALLASVRPSIRTPAPTTTSAILPRAYAIRPSSAAQFTRSFQSSLANRKGIHPESANPPAPNPQPGVAGAASHITEPSPLTPEEYYEYSEHYFNVLQSELERLQEEGSDVEAEYSAGVLNISVPAIGTYVLNKQPPNKQIWLSSPISGPKRYDWIVEGDYMHEKQESRPFVNGQWIYLRDGSNLTELLNSELTLSLPKDVYSQVIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W6QKM0</accession>
    <name>W6QKM0_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S05g000813</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QKM0"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM36980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="59" mass="6540" checksum="CB32CD0894F3BCC7" modified="2014-04-16" version="1">MLLSVPEGPPLGQSELIEIKEPRKLRGPSGDAYTLLYSESKSVISHLPSVQIEVVQMKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W6QLC1</accession>
    <name>W6QLC1_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PROQFM164_S03g001736</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM35009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QLC1"/>
    <dbReference type="STRING" id="1365484.W6QLC1"/>
    <dbReference type="OMA" id="KTDERYW"/>
    <dbReference type="OrthoDB" id="2585655at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000224">
        <property type="entry name" value="MFS transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF29">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G06680)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="102"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="137"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="167"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="197"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="227"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="345"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="383"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="425"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="459"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="487"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="522"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="265"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="273"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM35009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="562" mass="62209" checksum="AA3FEA7F23D2B8D4" modified="2014-04-16" version="1">MGLGVLEDTKLAHVPGTSDIYEQNGDASDQTPGASGLKCDWSGNQPIILVPQPSDDPNDPLNWPLWRRDTILAILSFVTILCTTLSSILAANTVTIADYEEITFTAAALLTGYHLCGVGVAGILIVPTARVWGKRHLFLIGHVLMIVSCIWAGVSGKNKNSLIWARIFQGVALAPFEALVNACVGDLYFVHERGKRMAVSNVALFGAAFLTPVVVGKITKSMGWQWSFYFVAIFLGSSLPLMFFFVPETAFRRSDYLNTDFKRSGGHGESMESHVSLSGASSDDTKEFRPRSNGINGSSKTEAAITVPEKDSFAQSLRLFNGRKTDESFFKLLLRPFPLFFHPGIFWACLIQGVVIGWAVFVGVVLAIVFLGPPMWFEEDKTGYLYTGAFIGSVVGLILSGLLSDSINKLMIRLNHGKYEPEFRILLVIPQLIFCGIGLYGFGWTANNVMHYGWLLPDVFFAFLIVGMVMGAVAASLYIVDAHREMAIEAFTCMLVFKNMFSFVLTFFAYKWFAHGGIKHTMIVIGSIQMGICLLSIPMYVFGKWNRSFFARHDILDMLYLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W6QLD2</accession>
    <name>W6QLD2_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aminotransferase, class IV</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S05g000614</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QLD2"/>
    <dbReference type="SMR" id="W6QLD2"/>
    <dbReference type="STRING" id="1365484.W6QLD2"/>
    <dbReference type="OMA" id="WRGSEMM"/>
    <dbReference type="OrthoDB" id="25921at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046394">
        <property type="term" value="P:carboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="entry name" value="D-amino Acid Aminotransferase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050571">
        <property type="entry name" value="Class-IV_PLP-Dep_Aminotrnsfr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42743">
        <property type="entry name" value="AMINO-ACID AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42743:SF11">
        <property type="entry name" value="AMINODEOXYCHORISMATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="D-aminoacid aminotransferase-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM36781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="335" mass="37475" checksum="3EE498BEC1CBA574" modified="2014-04-16" version="1">MTSMNEIFGAYAARKAVLEASSNPFAKGIAWVEGELVPFHQARIPMMDQGFLHGDLTYDVPSIWDGRFFRLDDHISRLDASCGKMRMQLPLPREEIKRILGQMATTSGIKDAFVELIVTRGLVGVRGSTPEQLTQQNLYMFVLPYSWVMEPEMQYRGGSAIIARTVRRTPVGCFDPTIKNLQWGDLTRGMFEASDRGATYPFLTDGDANLTEGSGFNIVLIKNGVLYTPERGVLEGVTRKSVFDAARANGIEFRVEIVPVESIYHCDELFMCTTAGGIMPITVLDGKPVNNGQVGPITKCIWDHYWAMHYDSTYSYALNYDNSEKPSDAGRQQRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W6QLI8</accession>
    <name>W6QLI8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S07g000051</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792021">
        <property type="protein sequence ID" value="CDM37703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QLI8"/>
    <dbReference type="STRING" id="1365484.W6QLI8"/>
    <dbReference type="OMA" id="MKYTEND"/>
    <dbReference type="OrthoDB" id="3353407at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021822">
        <property type="entry name" value="DUF3405"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36205:SF4">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36205">
        <property type="entry name" value="CHROMOSOME 19, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11885">
        <property type="entry name" value="DUF3405"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM37703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="631" mass="72999" checksum="ADF70D9846D85A3D" modified="2014-04-16" version="1">MDFFVALRKFFGSPRRCFAIAALCLVFFIVPYSREALVVPLRVKLSNPTEQPVDPFPSAYATQSRISAQLINDPYPHYDSAEWKSTSKGSYQPCIGPQGRLLSRKDEDMMMSGFRWNTSDFPTPTFGSYESWNLNNSLCADRYSRYGAYGFLEGKTTRTHNWNGTFGSNEAAEINWEQVDWANLQNDCLQRNSIRYRTQPSEGKILALYKSLDSDVQPREDLNETDKTVPRTAVILRSWIGMKYTENDLYHIRSMLMELSLYSGAEYELILLIDCQGEKLPEETDYAAWKAFKAKHLPQELRSLAVWFNEEMLNDWYPGIDVHVAILQYFQPTQIFSRLHPQYDYVWQFEMDSRYTGHMYDLLHKATEFAKQQPRKYLWERNSHFYMPAVHGTWEEFVKKVDQEMPGHDNSSVWGPHPAEGIDIEGQAIIPPVPYPKDEPGSWGVGEEADLITWLPHFNPVGTDWPFRDRVFNFPQDQETPRWAAVVAMSRISARLLGMLHKDKVKSGVGLASEMSPISWALYYGLKAVQIPQPIYHDAKWDPEELNRHVNPGEPGKVNAGLDSIWSWGQHDNIIYNTTFMFNSEFSEKLYRAWLGYDGAKEWEKNNPRLCLPPIFLHPVKNLESIKTKGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W6QLQ0</accession>
    <name>W6QLQ0_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S06g000326</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792020">
        <property type="protein sequence ID" value="CDM37365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QLQ0"/>
    <dbReference type="STRING" id="1365484.W6QLQ0"/>
    <dbReference type="OrthoDB" id="4772757at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM37365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="60" mass="6723" checksum="B8826C336671AC56" modified="2014-04-16" version="1">MIDLLESRGVTLAALTNAEKEKWETADGDGTLPLFDNVFISFEDEVDLDEGEGEDDEFRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W6QLZ8</accession>
    <name>W6QLZ8_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MARVEL-like domain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S02g000737</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QLZ8"/>
    <dbReference type="STRING" id="1365484.W6QLZ8"/>
    <dbReference type="OMA" id="WMMVMAS"/>
    <dbReference type="OrthoDB" id="3930290at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM30587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="179" mass="20900" checksum="4B6D3E426FFB85DA" modified="2014-04-16" version="1">MAVRRRREMRRRYHWPELQLNIWIMVVLSCAATCLGIFSWFMTVQSQMHLGTPWLFPYMVVSSALGVCFIFLIMILAARHFLLPGIIIIGSFILFVLWLTGLIETSLQLYGVVGNVNDNCQIYVTNNKAWGNNINTLAWLTQSTICNCWRTAFALELVNTIFYLWMMIMSWQVNRDVYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W6QM23</accession>
    <name>W6QM23_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S02g000767</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QM23"/>
    <dbReference type="STRING" id="1365484.W6QM23"/>
    <dbReference type="OMA" id="YGCGWVA"/>
    <dbReference type="OrthoDB" id="6082470at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="entry name" value="Leucine Aminopeptidase, subunit E, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="Macro domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM30617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="234" mass="26665" checksum="422DCEFAF299D94E" modified="2014-04-16" version="1">MTANIPEILLLCMDIDFITAFNDALKTTWPDHNPEKLKITPINERLNSLPEATTFDLIVSPANSYGRLDGAFDHAISMTFSPRKDYHALTRAAQKVLYEKWRGFAPPGSCTLVEFPDDLKQNKYGCGWVAICPTMREPGDARWDREVVYECVWSLLCQVEGHNRSAEEKEKIGRILMTPLAAGIGKVSKERWAVQTVLALRQFVDAIERPARWGNLGWEHIDEDCLEVERTWTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W6QMH2</accession>
    <name>W6QMH2_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Translocase of outer membrane 40 kDa subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">tom-40</name>
        <name evidence="14" type="ORF">PROQFM164_S06g000587</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Channel-forming protein essential for import of protein precursors into mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Tom40 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792020">
        <property type="protein sequence ID" value="CDM37625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QMH2"/>
    <dbReference type="STRING" id="1365484.W6QMH2"/>
    <dbReference type="OMA" id="TRFNYRW"/>
    <dbReference type="OrthoDB" id="19656at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046930">
        <property type="term" value="C:pore complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015288">
        <property type="term" value="F:porin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:monoatomic ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07305">
        <property type="entry name" value="Porin3_Tom40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.10:FF:000009">
        <property type="entry name" value="Mitochondrial import receptor subunit TOM40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.10">
        <property type="entry name" value="Porin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023614">
        <property type="entry name" value="Porin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027246">
        <property type="entry name" value="Porin_Euk/Tom40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037930">
        <property type="entry name" value="Tom40"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10802">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01459">
        <property type="entry name" value="Porin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="9" id="KW-0626">Porin</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1134">Transmembrane beta strand</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00053390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00078731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDM37625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="355" mass="38292" checksum="91584D087045499B" modified="2014-04-16" version="1">MADYLSSLSFLTENPAAAAINDAYSSFSDRRALLNLPNPGTVDNLAREVQKDVLLTNFMFSGLRADLTKVFGMSPLFRVSHAFSMGSTGNLPPYAFSAMYGSPRVFMQGNYGSDGALAAVANYRWNQALVTKTNAQIMNGGSQGLVQIDNDYTGRDFSASLKAFNPSLLEGGLTGIFVGSYLQSITPSLALGFEAIWQRQAITARPETALSYSAKYKGEDWIGTAQLQAQGTFNATYWRKLSERVEAGIDMNLQLQPSPATLMMGGPSRDGTTAIGAKYDFRASSFRAQVDSTGKVSCLLEKRIAMPISLSFAGEIDQAKQTAKLGLAVSLELAGEDVMEQQDKVDPATMIPPPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W6QN42</accession>
    <name>W6QN42_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">ER membrane protein complex subunit 7 beta-sandwich domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PROQFM164_S04g000455</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QN42"/>
    <dbReference type="STRING" id="1365484.W6QN42"/>
    <dbReference type="OMA" id="FTFGMPK"/>
    <dbReference type="OrthoDB" id="27095at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019008">
        <property type="entry name" value="Beta_sandwich_EMC7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039163">
        <property type="entry name" value="EMC7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13605">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13605:SF4">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09430">
        <property type="entry name" value="EMC7_beta-sandw"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004880354" description="ER membrane protein complex subunit 7 beta-sandwich domain-containing protein" evidence="7">
        <location>
            <begin position="20"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="ER membrane protein complex subunit 7 beta-sandwich" evidence="8">
        <location>
            <begin position="34"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="227"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="234"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF09430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM35574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="259" mass="27382" checksum="B104043817279BF2" modified="2014-04-16" version="1">MHFSLSSLLLLGISSLVSASSLTITIPVSSSLPNPHVLPATSHATLTTLPSSGKDHILSASLTRSATFVFHDLPSSNPDAQPESYLLDICSAGGYVFAPYRVDVAADGSILGIWETFRGNPWDNRGAEKYVVGVTGKKQVDVVVEAKVLGRKVFYEQRAQFSPLSLVKNPMVLLAVVALGLMFVMPKLMDNMDPEMRAEFEQHSRSSPITGATTSAMAGGGFDLASWMAGTGAPNPTASDVTQAGSTGRDTSGPARRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>W6QNA0</accession>
    <name>W6QNA0_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="10">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PROQFM164_S11g000066</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792025">
        <property type="protein sequence ID" value="CDM38363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QNA0"/>
    <dbReference type="OMA" id="MQTIAQW"/>
    <dbReference type="OrthoDB" id="508119at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF43">
        <property type="entry name" value="QUINATE TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G16230)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="160"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="316"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="358"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="386"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="417"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="453"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="486"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="52"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDM38363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="561" mass="62288" checksum="AD80256D1A4DF1A3" modified="2014-04-16" version="1">MPSSRSSSHVHSQITLHLLPGFIEYAPTARLYNLRAMRWTLKWSTNPYYALVIAVIACGGIPKGYDEGGYSASVSLPSFKSDYDLAKHPGFDDTELANRKANISSFNVLGAALGALLVLDLNDRLGRLVAWRLACVVWATGTLIQVFASGIYGLLLFSRIWGGLGAGALTVTAPLYLTEIAPAKTRGLVVGLYMVFLLAFLAMGFFINYGARVHMATTRTQYRLVQAVPLIPVGIAYGLSYLCPETPRYLVSKQLHQKGLEVLARLRGRDIDDPEITKEFATIDARERERQTDLAYVSHWAIFKETQMNPNYRQRFWLLMTMQTIAQWTGGNGITYYVTSIFQYAGLEGDSTSLVSSGAYGIVKLIFTMAFTWGLIDLIGRRRCTLAGLSLQLCAHIYMGIYMGLRPGSEDNKAASNAAVASVFVYAVGWSIGLCTVPYLYGTEVFPTRIRNVSYAISMALHWFFQFAVVRVTPNMFVSLHVWGAYLFWALICFSGLIILGVWMPETKGVPIERMGDLFDGPWYLRWRAKPREWDLASPTDTLENVSSKDGCVVKSAGSAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>W6QNB5</accession>
    <name>W6QNB5_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Coatomer subunit delta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PROQFM164_S11g000086</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 10">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10 11">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10 11">Cytoplasmic vesicle</location>
            <location evidence="10 11">COPI-coated vesicle membrane</location>
            <topology evidence="10 11">Peripheral membrane protein</topology>
            <orientation evidence="10 11">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10 11">Golgi apparatus membrane</location>
            <topology evidence="10 11">Peripheral membrane protein</topology>
            <orientation evidence="10 11">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the adaptor complexes medium subunit family. Delta-COP subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG792025">
        <property type="protein sequence ID" value="CDM38383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QNB5"/>
    <dbReference type="STRING" id="1365484.W6QNB5"/>
    <dbReference type="OMA" id="VQFRTHP"/>
    <dbReference type="OrthoDB" id="10266042at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051645">
        <property type="term" value="P:Golgi localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09254">
        <property type="entry name" value="AP_delta-COPI_MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14830">
        <property type="entry name" value="Delta_COP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000003">
        <property type="entry name" value="Coatomer subunit delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1170">
        <property type="entry name" value="Mu homology domain, subdomain B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036168">
        <property type="entry name" value="AP2_Mu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027059">
        <property type="entry name" value="Coatomer_dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028565">
        <property type="entry name" value="MHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10121">
        <property type="entry name" value="COATOMER SUBUNIT DELTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10121:SF0">
        <property type="entry name" value="COATOMER SUBUNIT DELTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00928">
        <property type="entry name" value="Adap_comp_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49447">
        <property type="entry name" value="Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51072">
        <property type="entry name" value="MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 10" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="5 10" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="7 10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MHD" evidence="13">
        <location>
            <begin position="276"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="154"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="176"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU366052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDM38383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="515" mass="57433" checksum="DDC3D0E4FAC9C8AC" modified="2014-04-16" version="1">MVVLAASICTRGGKAVLSRQFREISRSRIEALLASFPKLADSGTQHTTVEQDNVRFVYQPLDELYIVLITNRQSNILQDIDSLHLFAQVTTSICKSLDEREILRNAFELLSAFDELVTMGYRENLSLTQIKTFLEMESHEERIQEIIERNKELEASEERKRKAKQLEMQRKEAARTGRAAAPRTPTYPVYTPPARPSVPDSYDSYEAEKKQSFSKPIPTRGKGMQLGKKSKATDIYEKVRGDMGPEIEEESPLVAARASAPVHDIPSARESLQADREPIQLTIAETISATLTREGALKSFEVKGDMQLRISDPSLTKLRLDCQAIPTHGAQFRTHPNVDKALFTNSSVIQLKDTTKRFPANNSIGVLRWRVASSADNADILPITFTVWVNKGSDSTTVTVEYELTGDDSLRDVVVTIPYGTTEPAVSSFDAVYEVSGDSLDWNLGTVDQSNASGSFEFEAIDADENEFFPMSVHFTKTKPFVDVDINNVSLLDMEGEGVAFSKEVRSVADNFLIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W6QNC2</accession>
    <name>W6QNC2_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Conserved oligomeric Golgi complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PROQFM164_S06g000418</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COG1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792020">
        <property type="protein sequence ID" value="CDM37456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QNC2"/>
    <dbReference type="STRING" id="1365484.W6QNC2"/>
    <dbReference type="OMA" id="PQSLKSW"/>
    <dbReference type="OrthoDB" id="46189at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033370">
        <property type="entry name" value="COG1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31658">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31658:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08700">
        <property type="entry name" value="VPS51_Exo84_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="673"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="682"/>
            <end position="706"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM37456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="784" mass="87782" checksum="A75348B0014FB571" modified="2014-04-16" version="1">MAPEAPDPSSLKSWHDAFQYPIPTVRRVEQELRRDIASNKEKLRALVGTRYRDLVGTAETIVAMNRDIQGVESILADVGRRCNPRLIERKHVHVRQIETGDDEKDAEKHAFGAQLSLLHRCTTSTSRLLRRRGSLLLIAKILVVSRLLHKTLSKHESVPPFLDDLWNQLASLRQTLIKRIDKCLASTSATEDTIIESLAAYCLVESPSSDDAIHRFHRVRLGIIVNQLDVSRENIPRALQLFVRTLQASKVLRSHRFSDVLMKLKARPLLSDPEIQSLDGLEVEVLGRWVAPDVKNFTPWIKLSELSRTQGVESIKEWSLQAFNKFSDGCQKSLVHSTDFSELLSLRTETVELWLSSWGSTIIHGSVNVLESLRNIFNNQLARILNTQAQSLGEVGAQVSYIISEWENTEHSSVGSLWDSDLITAEYTNGAQAFKRTVVDRLLGRDEDVSTVLMKYQAWLASIEAVNESIDSLRRIRWTDILVGGEVEDEDIDITPRLNEDDPQHLSDSLHSAVRDAFSSLQTSFSSAFKSFNSSYSSEKATFLLRLIRLVRRDIPAGFVSGDFVFSSEIVPDLQKLLATEVVSKAGSLSLIPSPKYNPQTGKIKTVPGRSLWEGEPAIPVQPSVSSFKLLRRLTSSMDTCGLDLWDPSTVQALKQELKTKLEAAIASALDDLDSENTPSKAETKDVHPTANGDKQKEDKSAEKSEIQSPDPDQVAGLRDWRVQLFFDALYLSQMLGERNQLAGVVERAQKTAGSSAETVKTIKKLAAEYWTRTELLFGLLARQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W6QNG5</accession>
    <name>W6QNG5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Microtubule-associated protein, MAP65/ASE1-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S02g001337</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QNG5"/>
    <dbReference type="STRING" id="1365484.W6QNG5"/>
    <dbReference type="OMA" id="QLHGIYD"/>
    <dbReference type="OrthoDB" id="642895at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990023">
        <property type="term" value="C:mitotic spindle midzone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051256">
        <property type="term" value="P:mitotic spindle midzone assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1520">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007145">
        <property type="entry name" value="MAP65_Ase1_PRC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19321:SF41">
        <property type="entry name" value="FASCETTO-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19321">
        <property type="entry name" value="PROTEIN REGULATOR OF CYTOKINESIS 1 PRC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03999">
        <property type="entry name" value="MAP65_ASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="387"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="464"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="633"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="727"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="45"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="402"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="471"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="524"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="633"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="648"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="685"/>
            <end position="696"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM31187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="762" mass="85341" checksum="391FEFB25504ADEC" modified="2014-04-16" version="1">MAVDTSYLTTQVNNIVAQLHGIYDEIGVPARERESREAELFSALSETLNNHLKVVDEEREDMTQEAERLITAIQQMESSLSDERANGQYELNRDDLRVTYPLNKCIAFLREKNDSMSKLHRERFEQVKKLVDALESYSSHLEPSFVKLELPPTAPGSSIPPSFDLSPMYVTALDAEFTHVYEEYHRRIAKVQSACEEMIKLWAELGTPQAQTDSTIVKCYRDSPEQLGLHEDDVANLISKRNKLVEEKKSRERKINDLRATVISLWDRFGVEEADRKAFLAANRGCGLRIINDLEEELTRLNELKRQNLHLFVEDARCRLQELWDTLFFSEEEMLDFTPAFSDVCSDALLEAHEAEITRLEALKEQRAPTLEMIDRHRTLLTDREALETSSQDASRLMGRGNKGEKRDPGKLLREEKMRKRIAKELPKLEADLRKELEYWEDEFGRPFLVHGERYLDLLTPVKSMLPPRSKTPSATPSATKASTMRQNPPARPASSMRGLPPPRSATKTPTSSGPVKHNTIGYGASRAGATSRAGATSPSKLPARVPLGNMPLGTNSPERRMQPGAYSSGTLNGKMQPPRGPPPRMRALTIESREDRFSHLMEPPRCNSAMSSAYVRPVSPEDVYDDRQRSFMSTSGFSNSQRSTGFSHSSHSSHSSLSLNSSQVFPRPNPYLHHAAPPPAARQVSNSSTVNTTTSGSENWETFEDGSGSEADPSDIYYSKLRAANGGKRFAPEDGSDLTGKKTKGIRSVSPEGVLPLLPSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>W6QPK6</accession>
    <name>W6QPK6_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S02g001667</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QPK6"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM31517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="75" mass="8388" checksum="4909543CCE60E6AE" modified="2014-04-16" version="1">MSLLPKQLRRQNIMPVIISFEAVRKALLPLLQSLNYTKTSVLHSLRVGVPPMRCSVPSPTTRCELRCQVASPGKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W6QQV5</accession>
    <name>W6QQV5_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Altered inheritance of mitochondria protein 9, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Found in mitochondrial proteome protein 29</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PROQFM164_S05g000292</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AIM9 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QQV5"/>
    <dbReference type="STRING" id="1365484.W6QQV5"/>
    <dbReference type="OMA" id="WDGFVSH"/>
    <dbReference type="OrthoDB" id="2906425at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051035">
        <property type="entry name" value="Mito_inheritance_9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36091">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36091:SF1">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM36459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="480" mass="54026" checksum="5EDC7E978732FAAE" modified="2014-04-16" version="1">MYHYTSGRWLWNEKEQLSRRYVKFNLAELVKIATRATGSKSCVEVQKLPEGNFSKVFLLTMEDGKEVIAKLPNPNAGPQYFTTASEVATMDYVRNVLNIPAPTVYAWSLPTEEIGAEYSIMEKSRGVALGKVWDDLPGPDKLKIVHRLAGFEKALVSTRFPMYGSIYYADNLRNIDPDQVIELGDKKNTVSVKFAVDPTTNRTFFDDGRNSVNVQRGPWASLEDYAFARANRELACLQTFSKFPRPQGLFYGPGQYQPTAQRKQETLQNFLKIAKFLSPKDKEISKPVLWHPDLHGDNIFVNPDQPTEIISIIDWQAVNLSPLFLQARHPALIEFEGPIPEGLKAISLPDNFNELSPEEQLEAKKLRAAQSLYKHYDIQMIEDCPEIAAALKFKNSLAGQIMGLSGSLFSDGEPIVQGMLIRLQEEWGSRVGSSIPCPLSFTEEDKEHQKEDETKWASGVELMEEFLGQVGALGRLGESQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W6QR10</accession>
    <name>W6QR10_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S05g000342</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QR10"/>
    <dbReference type="OrthoDB" id="10515961at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM36509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="99" mass="10798" checksum="12FEC2ECBB0FB4EC" modified="2014-04-16" version="1">MHHTTPHGDISYFRVLFCTTSSISTYDDRVLVPGTTERCCTPPEGAQTLPHGAQGNEGAQNLPHGAHGSEGGQEACSYSPKWARRAFLSVPTTRLDKYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W6QRI5</accession>
    <name>W6QRI5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Mss4-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PROQFM164_S02g002308</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfa family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QRI5"/>
    <dbReference type="OMA" id="TLYCYFC"/>
    <dbReference type="OrthoDB" id="5290969at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="glutathione-dependent formaldehyde- activating enzyme (gfa)"/>
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    </dbReference>
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        <property type="entry name" value="CENP-V/GFA"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="CENP-V_GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337">
        <property type="entry name" value="GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04828">
        <property type="entry name" value="GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CENP_V_GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CENP-V/GFA" evidence="5">
        <location>
            <begin position="1"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDM32157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="154" mass="17139" checksum="030FFCEF2AA7A3BF" modified="2014-04-16" version="1">MGMKARCQCGQIQFTTPTDKPLKLWICHCTECQHQSSSAFGITATFPYFELPESASGLVDSYTRVTLKGRELECLFCRGCGARLLHRFRDAVPAPGEQPAFSAITNVKGGCLEDLDRGMMRTAVHIWCQHAVVDIPDGVERWEQEPPKPNPLVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W6QUE4</accession>
    <name>W6QUE4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM33152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QUE4"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM33152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="102" mass="11790" checksum="2AA7912AACDFBCBD" modified="2014-04-16" version="1">MKRNGLERQSLRRSVSEGDFSSGRGYSVYPFKGDSQDRLLWWYKKMVASTSMHRHPRTTSKNHFNPSTSIHPLHPSTSSIHFIHPLQSTIDIRHSTTAMLRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W6QVW5</accession>
    <name>W6QVW5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S10g000053</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792024">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OMA" id="WIREADY"/>
    <dbReference type="OrthoDB" id="4135672at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
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    </dbReference>
    <dbReference type="InterPro" id="IPR046670">
        <property type="entry name" value="DUF6540"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20174">
        <property type="entry name" value="DUF6540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM38239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="166" mass="19023" checksum="939DC8F821BCB726" modified="2014-04-16" version="1">MSDNPPASERYRVFTPEFDTAAPDPLDPAKRYHTGVFIQTDPDIFEGDLFHVTGDIIAAKGMYFDVKESYTPGASAHFHRTTEIGWIYKVDFPRIRGILEALPTPTKQQGIDFWSHDPSKRNKITWTKENGELYGPGEQRRPIIKCNEWTHQIAIPKLRQEGILHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W6QW52</accession>
    <name>W6QW52_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Short-chain dehydrogenase/reductase SDR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PROQFM164_S11g000052</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792025">
        <property type="protein sequence ID" value="CDM38349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QW52"/>
    <dbReference type="STRING" id="1365484.W6QW52"/>
    <dbReference type="OMA" id="MTGSDCI"/>
    <dbReference type="OrthoDB" id="1888931at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050085">
        <property type="term" value="F:mannitol 2-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050664">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019594">
        <property type="term" value="P:mannitol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000090">
        <property type="entry name" value="NADP-dependent mannitol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008">
        <property type="entry name" value="BENZIL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008:SF1">
        <property type="entry name" value="NADP-DEPENDENT MANNITOL DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDM38349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="276" mass="29960" checksum="8174F86620DC6932" modified="2014-04-16" version="1">MSMTIEDCTQDREGFPRPFPDTPTNVLEQFKMNGKVVVVTGAADGLGHAIAQGMAEAGAHVALWYNSNDVAIEKAQVLAKEHGIKASAYKVDVSESNQVSETITKVVADFGKIDVFVANAGMAISKPILEQTLDEYRKQMSVNVDGIVYCAKYAGEVFARQGRGNLIITSSMSAHIVNVPTDQPVYNATKAYVTHFGKSLAREWRDFARVNIVSPGFFDTKMGAGPFALKEAYRMSSLGRQGHVKEIKALYLYLASDASTFMTGSDVLIDGGYVLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W6QWS0</accession>
    <name>W6QWS0_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Short-chain dehydrogenase/reductase SDR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S03g000701</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QWS0"/>
    <dbReference type="OMA" id="HHNVHVI"/>
    <dbReference type="OrthoDB" id="7289984at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05325">
        <property type="entry name" value="carb_red_sniffer_like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052184">
        <property type="entry name" value="SDR_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45458:SF3">
        <property type="entry name" value="CHAIN DEHYDROGENASE (ATSC), PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45458">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE SDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM33977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="267" mass="28186" checksum="DD78443E8AD8CF73" modified="2014-04-16" version="1">MASYAITGASKGIGLEYVRQLAANKDNTVLAIVRNPESQGISELATRHPNVHAIKGDVTDPKSILDAASAAAAITGGKLDVLIHNSNAVDMAAMGLNPSQIPFDAEATRKIFEPSLSTGVYGGLWATNAFLPLIEKGTQKKIVHISSAMADLDLIIKSGVSYAVAYSVSKAGMNVQVAKYAAELAPKGIKVLALSPGWVDTWEGEKPAELIQALAGMLSQFQAVEPGLTGQIQPEESVRKGLQVIEKLDAESSGLFLSQNGNQTNWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W6R4X8</accession>
    <name>W6R4X8_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NlpC/P60-like cell-wall peptidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S05g000705</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6R4X8"/>
    <dbReference type="STRING" id="1365484.W6R4X8"/>
    <dbReference type="OMA" id="KPYRYIR"/>
    <dbReference type="OrthoDB" id="5358886at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1720.10">
        <property type="entry name" value="endopeptidase domain like (from Nostoc punctiforme)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004882165" description="NlpC/P60-like cell-wall peptidase" evidence="1">
        <location>
            <begin position="20"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM36872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="248" mass="26789" checksum="A714C2937D9949D5" modified="2014-04-16" version="1">MRFTNLALTLAAAFSVANAYAITASVANCRTGPSTSNAVVTTYKKGADVKITCQTYGENIQGNSIWDKTSDGCYVADYYVKTGSNSMVTKDCNGGSSGTGSSSYKGKISRKEIISRGQFWVSRHIPYSMNAEYPDPQGRKYRTDCSGFVSMAFHAYAPGYNTVSLPDIAKSISWSDLRPGDFVGTLGAGTGGAAGHVTLFTSWADSSKKEYNTLECRGTYGCVAYRRPVGWKVGSFTAKPYRYIHVVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W6R854</accession>
    <name>W6R854_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Galactose oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">GAOA</name>
        <name evidence="4" type="ORF">PROQFM164_S08g000098</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792022">
        <property type="protein sequence ID" value="CDM38047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6R854"/>
    <dbReference type="STRING" id="1365484.W6R854"/>
    <dbReference type="OMA" id="DNSTYWH"/>
    <dbReference type="OrthoDB" id="2019572at2759"/>
    <dbReference type="UniPathway" id="UPA00280"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02851">
        <property type="entry name" value="E_set_GO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.80">
        <property type="entry name" value="Galactose oxidase/kelch, beta-propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037293">
        <property type="entry name" value="Gal_Oxidase_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009880">
        <property type="entry name" value="Glyoxal_oxidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015202">
        <property type="entry name" value="GO-like_E_set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32208:SF68">
        <property type="entry name" value="GALACTOSE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32208">
        <property type="entry name" value="SECRETED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07250">
        <property type="entry name" value="Glyoxal_oxid_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09118">
        <property type="entry name" value="GO-like_E_set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01344">
        <property type="entry name" value="Kelch_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004880191" evidence="2">
        <location>
            <begin position="20"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="3">
        <location>
            <begin position="51"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM38047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="719" mass="79286" checksum="0A8D1852D8C500FE" modified="2014-04-16" version="1">MKLQWAGLLFGASIGGVNGMAEYMHEAMRGERVSGYGKPDNPSWVPQFKDESPPYQGHRISRQDWTVICSSSASGYPCKHAIDGKNGTSWHSDPSEKGHTFVVDLGAWYQVGAVVVLPPIDTDTEGLITQHKIWVSEDHESWTGPVAYGMWPNTNRQRMSAFEPSSTRYLRITTDADKENPWVGIAELNIYGTLYTIPRDPALGVWGPTLDFPIVPVAGAQEGSGMLALWSSWADDQFHSTPGGKTVMTRWNPLTGEVSKRTVSNTHHDMFCPGISYDGTGMMVVTGGNDASETSLYDSAKDEWVRATEMKLRRGYQASTTLSDGRVFVIGGSWAGGSNVDKDGEVYDPATRNWTMLPEAKVSKMLTGDMEGPWRADNHGWLFGWKNLSIFQAGPSKQMNWYSAHDNGSVKAAGDRMDDDDSMSGNAIMFDAVKGKILTLGGSPDYDKSWSTNAAHIITIGEPGEEPKVEPAGNGTMHYERVFHTTVVLPDGKVAIFGGQQYGVAFNEERVQFIPEIYDPETNTFTKLQQNNVVRVYHTVSILLPDARVLNAGGGLCGNCSANHYDGQIFTPPYLLSPSGQPRPRPEILSGLPDHTLVGSTLRFKTSGRISTASLIRLGTATHTVNTDQRRIPLDVTATSFFRNTWKTTLPEDSGILIPGYWMLFVLDRHGVPSIGKIMMIGLDDTKTIQPAQDPLSVMEEQNNIGTFMRIELLRRKWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W6R8H6</accession>
    <name>W6R8H6_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Protein kinase-like domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S09g000083</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792023">
        <property type="protein sequence ID" value="CDM38167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6R8H6"/>
    <dbReference type="STRING" id="1365484.W6R8H6"/>
    <dbReference type="OMA" id="HPRGWNT"/>
    <dbReference type="OrthoDB" id="411145at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004119">
        <property type="entry name" value="EcKL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052961">
        <property type="entry name" value="Oxido-Kinase-like_Enzymes"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23020:SF41">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23020">
        <property type="entry name" value="UNCHARACTERIZED NUCLEAR HORMONE RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02958">
        <property type="entry name" value="EcKL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM38167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="420" mass="47076" checksum="BE5792AD24CDAB21" modified="2014-04-16" version="1">MAPHDPNRVASIMLSWHSLELISCTNLQTLWAGYGQICAITARATTSQAAEHLSKLCGVEPGVVGTTYPLILKLISPPRKSASTADEGHLRKMLSYEVEQYFYSEVVPQLSCNTAIAKCVASTRDMDYSADSSELSGLMATIMVDLRPEFPIAGEKRGALNRAQVRAALDWLAGFHSCSRKLLPSSLDGYILPPLEERNRRQRQSPDKDVGSGLWLNGGYTYLATRRKEYASLAQDTDSEWSDALCRVSEGCSLSVAEMVALFLTPCGRAIESYIHGDVKSENLFTTTNGDKVAFFDFQYVGLGLGVCDLAKLFTCSVPLHMLVDGNGSLPAQLSMCDAERALLERYRMSLLQDEESEESELYEWEAFKRHWETALVDWCRFQASWGFWGNTEWLGARVRSILNDQEWRDWLYQNIRGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W6PQE1</accession>
    <name>W6PQE1_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ER membrane protein complex subunit 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PROQFM164_S01g000207</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EMC6 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PQE1"/>
    <dbReference type="STRING" id="1365484.W6PQE1"/>
    <dbReference type="OMA" id="PDSVMHN"/>
    <dbReference type="OrthoDB" id="16510at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008504">
        <property type="entry name" value="Emc6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029008">
        <property type="entry name" value="EMC6-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20994">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20994:SF0">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07019">
        <property type="entry name" value="EMC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM26398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="153" mass="16048" checksum="3DE0416CBEC1CFB8" modified="2014-04-16" version="1">MAPTKQELSLLITPLVPEAVQHNNRVLSSLHSLTSFLLGLSAGILALQSGYGFAFYFLGTILVSGLFHAVLIHRSGGAGAGSFFPGSTPGEIEGVIEMNEKSKAVHMQLAGKAGPRKIIRKGAWRDVWFGGGVMSEALSGFVLGWAGVGGVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W6PR45</accession>
    <name>W6PR45_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">N-alpha-acetyltransferase 40</fullName>
            <ecNumber evidence="4">2.3.1.257</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PROQFM164_S01g000477</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N-terminal L-seryl-[histone H2A] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-seryl-[histone H2A] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50600"/>
            <dbReference type="Rhea" id="RHEA-COMP:12742"/>
            <dbReference type="Rhea" id="RHEA-COMP:12744"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:64738"/>
            <dbReference type="ChEBI" id="CHEBI:83690"/>
            <dbReference type="EC" id="2.3.1.257"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>N-terminal L-seryl-[histone H4] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-seryl-[histone H4] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50596"/>
            <dbReference type="Rhea" id="RHEA-COMP:12740"/>
            <dbReference type="Rhea" id="RHEA-COMP:12743"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:64738"/>
            <dbReference type="ChEBI" id="CHEBI:83690"/>
            <dbReference type="EC" id="2.3.1.257"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the acetyltransferase family. NAA40 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.257" evidence="4"/>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PR45"/>
    <dbReference type="STRING" id="1365484.W6PR45"/>
    <dbReference type="OMA" id="KEVVYCY"/>
    <dbReference type="OrthoDB" id="424551at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043998">
        <property type="term" value="F:histone H2A acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010485">
        <property type="term" value="F:histone H4 acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990189">
        <property type="term" value="F:protein N-terminal-serine acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039949">
        <property type="entry name" value="NAA40"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20531">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20531:SF1">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="13">
        <location>
            <begin position="134"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="137"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="14"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="150"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDM26668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="289" mass="32361" checksum="28A8A1CB7A48F491" modified="2014-04-16" version="1">MPSVKEGRVEKFKAKTPRTTTRRVSSKIPLVEQTNALSISDFVAQYVTPPTQVGDSAENDAIDQLHPSQDQPQQDMIPMSRMDVYSAATIPAADLEACLDLIEQTSSQAYMASNAGWSRTKKRKEMKLPDMKYLILRDAPNDNSDPSGRVPREKQRDIADNNAPSPPPKEREEPISSPDTVSGNVLGFLSFMVTYEDGKEVVYCYEIHLSPTARGRGVGRLLMGRMEAIAGAVGLEKSMLTVFKSNEIARRFYERLGYEVDEYSPRPRKLRNGTIKDVDYLILSKILKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W6PR52</accession>
    <name>W6PR52_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type DNA-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PROQFM164_S01g000149</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PR52"/>
    <dbReference type="STRING" id="1365484.W6PR52"/>
    <dbReference type="OMA" id="ERMSQWL"/>
    <dbReference type="OrthoDB" id="5089701at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF46">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="21"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM26340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="686" mass="77765" checksum="DA2BA0AB5316BE46" modified="2014-04-16" version="1">MADSPQEGVHEAITHTRSFTGCVTCRSRHVKCDEGRPECSMCQYFGLACGGYKKVIFFDFESSLRNHGVRFRRPLFTVKERERMSQWLVSSAPPKKTHHILSQIDEECERATTSEEIEIHQGPFGAFRSNQGQDTIPREPAMNDFEETQSSSPEDVVLFSNSSDMLLSPWSQSLTHFTFDQPEHVPSPPSLVCLDAMIDQDSVEDDPVPHGYLPTSCLPDQSYNHPILPNLFTSSTGTTKALPQDAVFLLKHYASAVISLMTPLRHSKTPWHILFIPHTKSCLAGLVLGDNMSDASLCAFYGTLAISAFSLGGVSRSQTWSEKAIIYKQKAQQHAKMMLMTAYNFPKVAKYKSILMALLTMVQVTMFSGSRRESEYYFVEAEKFIRLRGLPRKKSRKVRLLHHCYVFERIIHESVFICGANSRQRHHVHAAIETSGLGNYSLDSLSFRLSGWKNLDQEMMRVRGQEEGENDLHLERPGFWSNTLYPEIFGIPEPWVLLLSQVIRLGKEKDAAEREDASNCISLKEFISRAKTLEDYINKLPLPSLENIQSEFDHEVIDNMLNAMQNALAIYFYRRIYDVDASLLQQKVVVVLDHLLRCENTDSTVVHGSAGFTWPAFIAACEADDPLVQASFSNWFVNSARRSGLSCFTETLANIQRIWQEKTCANGKSVTWLDLMKGSMPIHQIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W6PRL1</accession>
    <name>W6PRL1_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NADP oxidoreductase, coenzyme F420-dependent</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PROQFM164_S01g000314</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the pyrroline-5-carboxylate reductase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PRL1"/>
    <dbReference type="STRING" id="1365484.W6PRL1"/>
    <dbReference type="OMA" id="IPNMGAQ"/>
    <dbReference type="OrthoDB" id="10263291at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004735">
        <property type="term" value="F:pyrroline-5-carboxylate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3730.10">
        <property type="entry name" value="ProC C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01925">
        <property type="entry name" value="P5C_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028939">
        <property type="entry name" value="P5C_Rdtase_cat_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029036">
        <property type="entry name" value="P5CR_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000304">
        <property type="entry name" value="Pyrroline-COOH_reductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11645:SF21">
        <property type="entry name" value="HYPOTHETICAL PYRROLINE-5-CARBOXYLATE REDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11645">
        <property type="entry name" value="PYRROLINE-5-CARBOXYLATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03807">
        <property type="entry name" value="F420_oxidored"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14748">
        <property type="entry name" value="P5CR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000193">
        <property type="entry name" value="Pyrrol-5-carb_rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyrroline-5-carboxylate reductase catalytic N-terminal" evidence="3">
        <location>
            <begin position="7"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="Pyrroline-5-carboxylate reductase dimerisation" evidence="4">
        <location>
            <begin position="189"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="10"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000193-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDM26505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="292" mass="30820" checksum="42CAFFDF7848DD65" modified="2014-04-16" version="1">MASGQTLGFIGCGNMGGAVLKGLLNSVFSATSTDPTPNPITRFIACTKTASSASRLEKTIAPEHQQLIKIVSDQTVQTMQEADVIILGCKPFMAEAVLREEGVRDALAGKLVISMLAGQSCETLTRLINPDPGAADQPHLMKAIPNMGAQFGQSMTIIETPAPSIPPAMVLVTEWIFKHVGAVKYLKAEQIGLATVLVGATMATLTLPIEGLLDGCVAEGFKRADAMELVLQGIRGLSAVLESGQHPAVVRESISSPRGCTIQTLLSLEKAGTRSDFAEAIVRGNTHLKEKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W6PUK8</accession>
    <name>W6PUK8_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S01g001257</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PUK8"/>
    <dbReference type="OMA" id="ICPGRRC"/>
    <dbReference type="OrthoDB" id="1689567at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="68"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="488"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="498"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM27446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="750" mass="83021" checksum="DC72FCB28F577861" modified="2014-04-16" version="1">MPALRSSGQDYTRLMSKNASTTHTKRNSTRPIPPILNKSVTKYMAQGQYLSKRNSTSSSSRPAANIAPAEILLEIFSMLTPRDFDNARRTCSQWMRISLNHKLLENMLKRAGWWDAWLQDCQTPRVSRLDESEVWRMSRRFATECLLSGRKLNAEKPGFLTTAVVDFSNLSDSARRTSRTRLQPVLQTEGKRSGSTFSISSCSNYLLVTTGYTIYIYYLSGQRSRPASAPFSHGIALVSRISCPFEILSAVIDTSKPQFTIAALLCSRVGMICNLDMAWAKDSTTKGSHFNSKMATSSRHFFYNICTVDNPPRTVALCPGRPIVAFGCAAGIEIHSLNETKHQEQRRHFTLPQPSEILHFLPSSPETPNELRLISSLSGPGLHECKCPPSPSPSPSSALASPKLDPKSNQFHFLADIQSFNRRIIPHTPSRSFVRATHCHHYRAVPINDGLHIMFIEPRTSLLCIGTDAPIGGPTSLTRAFVCVPPPFSNTQNRQIKTPPPSPSPSNTNPPPTDLPVPSTFTAGSDLRWGLRIVAVYGDRLVLYSIPLDVFNVIRKERERQGDGVMGSSDLALDWYIDSERSRKRRESLVQNQNGDWDFLLSVPYRPTAMMWPFKIYGKEIGSVKGTVELALQSSEGGVRVWTFGKDGKATVLDVDTGDAPTRSLGVGSDGELEDLGIVQRACSTGIRSRKRKFEEVKTGFAGRHGAGRYSADGVNVKPCAAGVHGIHQDPSVRRSSFAACIIDFKIPLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>W6PUQ5</accession>
    <name>W6PUQ5_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glutamate dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">GDH</name>
        <name evidence="12" type="ORF">PROQFM164_S01g001764</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-glutamate + NADP(+) + H2O = 2-oxoglutarate + NH4(+) + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11612"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.4.1.4"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homohexamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 10">Belongs to the Glu/Leu/Phe/Val dehydrogenases family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PUQ5"/>
    <dbReference type="STRING" id="1365484.W6PUQ5"/>
    <dbReference type="OMA" id="PCFAAFP"/>
    <dbReference type="OrthoDB" id="6718861at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004354">
        <property type="term" value="F:glutamate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006537">
        <property type="term" value="P:glutamate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05313">
        <property type="entry name" value="NAD_bind_2_Glu_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.285.10:FF:000001">
        <property type="entry name" value="Glutamate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.285.10:FF:000003">
        <property type="entry name" value="Glutamate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10860:FF:000002">
        <property type="entry name" value="Glutamate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000030">
        <property type="entry name" value="Glutamate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.285.10">
        <property type="entry name" value="Glutamate Dehydrogenase, chain A, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10860">
        <property type="entry name" value="Leucine Dehydrogenase, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006095">
        <property type="entry name" value="Glu/Leu/Phe/Val/Trp_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006096">
        <property type="entry name" value="Glu/Leu/Phe/Val/Trp_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006097">
        <property type="entry name" value="Glu/Leu/Phe/Val/Trp_DH_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033524">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014362">
        <property type="entry name" value="Glu_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050724">
        <property type="entry name" value="Glu_Leu_Phe_Val_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033922">
        <property type="entry name" value="NAD_bind_Glu_DH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006929">
        <property type="entry name" value="PRK09414.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43571">
        <property type="entry name" value="NADP-SPECIFIC GLUTAMATE DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43571:SF1">
        <property type="entry name" value="NADP-SPECIFIC GLUTAMATE DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00208">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02812">
        <property type="entry name" value="ELFV_dehydrog_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000185">
        <property type="entry name" value="Glu_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00082">
        <property type="entry name" value="GLFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00839">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00074">
        <property type="entry name" value="GLFV_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 6 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal" evidence="11">
        <location>
            <begin position="191"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="115"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="387"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalysis" evidence="9">
        <location>
            <position position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDM27953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="461" mass="49730" checksum="DB7D0E32792C9CFD" modified="2014-04-16" version="1">MIQNLPFEPEFEQAYKELASTLENSTLFEKKPEYRKALQVVSVPERIIQFRVVWEDDQGQVQINRGYRVQFNSALGPYKGGLRFHPTVNLSILKFLGFEQIFKNALTGLNMGGGKGGSDFDPKGKSDSEIRRFCVSFMTELCKHIGADTDVPAGDIGVTGREVGFMFGQYKKIRNQWEGVLTGKGGSWGGSLIRPEATGYGLVYYVDHMIKYASGGKESFAGKRVAVSGSGNVAQYAALKVIELGGSVVSLSDSQGALILNGEEGSFTVEEINAIAAIKVERKQISELATVATFSSKFKYIPGARPWTNITGRIDVALPSATQNEVSGDEAKALIAAGCKFIAEGSNMGSTQDAIDVFEAHRTANPGAAAIWYAPGKAANAGGVAVSGLEMAQNSARVNWSREEVDSRLQKIMEDCFNNGLATAKEYVTPTEGVLPSLVAGSNIAGFTKVAEAMKEHGDWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W6PV71</accession>
    <name>W6PV71_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PROQFM164_S01g001954</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PV71"/>
    <dbReference type="STRING" id="1365484.W6PV71"/>
    <dbReference type="OMA" id="FVEPPME"/>
    <dbReference type="OrthoDB" id="68483at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004683">
        <property type="term" value="F:calcium/calmodulin-dependent protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14008">
        <property type="entry name" value="STKc_LKB1_CaMKK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000995">
        <property type="entry name" value="BcCMK3, calcium/calmodulin-dependent protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000447">
        <property type="entry name" value="Calcium/calmodulin dependent protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF77">
        <property type="entry name" value="SERINE THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="85"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="131"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="383"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="501"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="744"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="35"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="47"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="582"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="757"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="801"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDM28143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="824" mass="91951" checksum="241D4930F261E7E8" modified="2014-04-16" version="1">MDENQAMATPMSDISAEPSTISLEGVNDARPQASRVGSSASYDSTGRHRRRNPRARRPVKETLDARSEYYTSQDDGTAEHRINQYVIKQEIGRGSFGAVHLAADQFGNEYAVKEFSKSRLRKRAQSHLLRRPRGPIRPGTEFNSPLHRHPSGDDKELGENPLYLIKEEIAIMKKLHHNNLVSLIEVLDDPTEDSLYMVMEMCKKGVVMKVGLEERADPYDDEQCRCWFRDLILGIEYLHSQGIVHRDIKPDNCLVTNDDMLKVVDFGVSEMFEKDSNMFTGKSAGSPAFLPPELCVVKHGDVSGRATDIWSMGVTLYCLRYGKLPFEKQSIFELYDSIRGDPVDYEEESDEEFKDLMQRILEKDPEKRIDMFGLREHPWVTKDGTDPLLSFEENTSQPIEPPTEEEMNSAITTNMGNLMTVVKAVKRFKRLTDPTKPQSPIESTFGKSILGGDHDAYFVEPPMEMDPDEPFPAVGAAPQTHDGHDFSAGVRKYFGRRPFAGLRDDSGGFGSSDSASFSSRPEYSPNSSKRPSGVFEPERKDSGSIRSWGSAQPDIGHEALPHSQSGSPHIPLSRASSGRTKRSLEGTRGHARDPLEEEFPYLFIGPSTYTGSSQPEAVGTEISGDPGSILQTLEHSMDHSDQMEDDEPVQFVSESPGAADFNIYETAYRKELDRIKHNLKDRDTGPKVYLTRVIEKNSDEVVKLAKEKELDLQTGNEFTPFSLPRTSLGFGHAVNAVRSQMLQKRQAGELEEQGGEGSKDRGSSQNRELHPHPPKRLSVSSQALLKPEPSSLEATGVSSTEGKDSKAQLRRILDRVRGKSDGAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W6PVB0</accession>
    <name>W6PVB0_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Carbamoyl phosphate synthase arginine-specific large chain, mitochondrial</fullName>
            <ecNumber evidence="14">6.3.4.16</ecNumber>
            <ecNumber evidence="5">6.3.5.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Ammonium-dependent carbamoyl phosphate synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Arginine-specific carbamoyl phosphate synthetase, ammonia chain</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Glutamine-dependent carbamoyl phosphate synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="primary">arg4</name>
        <name evidence="24" type="ORF">PROQFM164_S01g001527</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>hydrogencarbonate + L-glutamine + 2 ATP + H2O = carbamoyl phosphate + L-glutamate + 2 ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:18633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>hydrogencarbonate + NH4(+) + 2 ATP = carbamoyl phosphate + 2 ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:18029"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-arginine biosynthesis; carbamoyl phosphate from bicarbonate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Heterodimer composed of 2 chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CarB family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.16" evidence="14"/>
    <dbReference type="EC" id="6.3.5.5" evidence="5"/>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PVB0"/>
    <dbReference type="STRING" id="1365484.W6PVB0"/>
    <dbReference type="OMA" id="FPFNKFP"/>
    <dbReference type="OrthoDB" id="1924069at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004087">
        <property type="term" value="F:carbamoyl-phosphate synthase (ammonia) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004088">
        <property type="term" value="F:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01423">
        <property type="entry name" value="MGS_CPS_I_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000004">
        <property type="entry name" value="Carbamoyl-phosphate synthase (glutamine-hydrolyzing)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1380:FF:000015">
        <property type="entry name" value="Carbamoyl-phosphate synthase arginine-specific large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1030.10:FF:000001">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000001">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000001">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.20:FF:000001">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.20:FF:000002">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1030.10">
        <property type="entry name" value="Carbamoyl-phosphate synthetase, large subunit oligomerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1380">
        <property type="entry name" value="Methylglyoxal synthase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036897">
        <property type="entry name" value="CarbamoylP_synth_lsu_oligo_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CPAse_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005483">
        <property type="entry name" value="CPSase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006275">
        <property type="entry name" value="CPSase_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005480">
        <property type="entry name" value="CPSase_lsu_oligo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058047">
        <property type="entry name" value="CPSase_preATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011607">
        <property type="entry name" value="MGS-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036914">
        <property type="entry name" value="MGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01369">
        <property type="entry name" value="CPSaseII_lrg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003671">
        <property type="entry name" value="PRK05294.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009455">
        <property type="entry name" value="PRK12815.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11405:SF53">
        <property type="entry name" value="CARBAMOYL-PHOSPHATE SYNTHASE [AMMONIA], MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11405">
        <property type="entry name" value="CARBAMOYLTRANSFERASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25596">
        <property type="entry name" value="CPSase_L_D1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02787">
        <property type="entry name" value="CPSase_L_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00098">
        <property type="entry name" value="CPSASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01096">
        <property type="entry name" value="CPSase_L_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48108">
        <property type="entry name" value="Carbamoyl phosphate synthetase, large subunit connection domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52335">
        <property type="entry name" value="Methylglyoxal synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51855">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 21" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="12" id="KW-0464">Manganese</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9 21" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ATP-grasp" evidence="22">
        <location>
            <begin position="218"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="22">
        <location>
            <begin position="755"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="domain" description="MGS-like" evidence="23">
        <location>
            <begin position="1019"/>
            <end position="1168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00044063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00044249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00044318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00044334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00047359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00068891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="CDM27716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="1168" mass="128281" checksum="FEE0A8DBDF802833" modified="2014-04-16" version="1">MALAARCGQAAALLRQRCIAETRPALSLRAFSSQSVRSTASTLRLQKIPTARSQQLRSFSSTLNRLAAERPPAAESYLASGAVSAGSNLVDVKKVLVIGSGGLSIGQAGEFDYSGSQALKALKEAGVHSILINPNIATIQTDHKLADEVYYLPVTPEYVTHVIERERPDGILLTFGGQTALNLGVQMNRMGTFERYGVKVLGTPIKTLETSEDRDLFAQALNEIDIPIAESTAVETVEDALKAAEQVGYPIIVRSAYALGGLGSGFANNPDELRDLSSRSLSLSPQILVEKSLKGWKEVEYEVVRDAANNCITVCNMENFDPLGIHTGDSIVVAPSQTLSDEEYHMLRTAAIKIVRHLGVVGECNVQYALQPDGLDYRVIEVNARLSRSSALASKATGYPLAYTAAKIGLGHTLPELPNAVTKTTTANFEPSLDYVVTKIPRWDLSKFQHVNRDIGSAMKSVGEVMAIGRTWEESLQKAIRQVDPQYLGLQGDKFDDLDETLRNPTDRRWLAVGQAMLHENYSVDKVHELTKIDKWFLYKIQNIVDCNNELKEIGSLFGLKQEILMKAKKLGFSDKQISLLVGSTEDDVRARRKSFGITPWVKKIDTLAAEFPADTNYLYTTYNASSHDVTFDDHGIIILGSGVYRIGSSVEFDWCAVNATLSLREMGKKTVMINYNPETYSTDFDTADKLYFEELSYERVMDIYELEASSGVVVSVGGQLPQNIALRLQESGGATIMGTNPLDIDKAEDRHKFSSILDSIGVDQPAWKELTSVADAEVFADTVGYPVLVRPSYVLSGAAMNVIYGVDELKEKLLNAAAVSPDHPVVITKFIEGAEEIDVDAVASNGKLLVHAVSEHVEPAGVHSGDATLVLPPATLEEPIMARVKEIAEKVAKAWNITGPFNMQIIKADQEGGEPALKVIECNLRASRSFPFVSKVLGTNFIDVATKALVGRDVPEPVDLMKVKRDYLATKVPQFSWTRLAGADPFLGVEMSSTGEIACFGKDLIEAYWSSLQSTMNFRVPEPGEGILLGGDTNQPYLTRIVDYLHPLGYKFYAVNPEVKAHIESTAQNDVSVKLIEFPKKDKRALREVFQKYDIRGCFNLAKTRGKTQLDEDYVMRRNAVDFSVPLFMEPKTAQLFAQCMSQKLPRAEGIPSEVRTWANFVGGKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>W6PVW0</accession>
    <name>W6PVW0_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">EKC/KEOPS complex subunit BUD32</fullName>
            <ecNumber evidence="7">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="25 26">Atypical Serine/threonine protein kinase BUD32</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">EKC/KEOPS complex subunit bud32</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="30" type="primary">bud32</name>
        <name evidence="30" type="ORF">PROQFM164_S01g002164</name>
    </gene>
    <organism evidence="30 31">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="30" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="30">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. BUD32 has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit KAE1. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptional coactivators.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="32">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="32">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the EKC/KEOPS complex composed of at least BUD32, CGI121, GON7, KAE1 and PCC1; the whole complex dimerizes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Chromosome</location>
            <location evidence="4">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the protein kinase superfamily. BUD32 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="7"/>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PVW0"/>
    <dbReference type="STRING" id="1365484.W6PVW0"/>
    <dbReference type="OMA" id="HKLYMEY"/>
    <dbReference type="OrthoDB" id="3399at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000408">
        <property type="term" value="C:EKC/KEOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070525">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000603">
        <property type="entry name" value="EKC/KEOPS complex subunit bud32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000845">
        <property type="entry name" value="Probable bifunctional tRNA threonylcarbamoyladenosine biosynthesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022495">
        <property type="entry name" value="Bud32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03724">
        <property type="entry name" value="arch_bud32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12209:SF0">
        <property type="entry name" value="EKC_KEOPS COMPLEX SUBUNIT TP53RK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12209">
        <property type="entry name" value="NON-SPECIFIC SERINE/THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06293">
        <property type="entry name" value="Kdo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="22" id="KW-0010">Activator</keyword>
    <keyword evidence="19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0158">Chromosome</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="18" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="17 30" id="KW-0418">Kinase</keyword>
    <keyword evidence="16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="24" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="31" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="20" id="KW-0779">Telomere</keyword>
    <keyword evidence="23" id="KW-0804">Transcription</keyword>
    <keyword evidence="21" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="14" id="KW-0808">Transferase</keyword>
    <keyword evidence="15" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Protein kinase" evidence="29">
        <location>
            <begin position="17"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00013948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00019973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00030980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00033194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="EMBL" id="CDM28353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="274" mass="30081" checksum="7393C57844ECDAEF" modified="2014-04-16" version="1">MEEYKPPALPSPFNNTIPPPILLTQGAEAHLYKTTSLDPSIPAALKIRPSKPYRHPILDRRLTRQRIISEARCLAKLIREGVSVPALLALDWEGHGGPEGGWGGAWLMMEWIDGPVVRVVLEQWEAWMKQNEGSLDESQIENEEARVRGLLRKMGSAIGVLHKAGIVHGDLTTSNLMLRPSADAGDAVEGTGAPSLEGDVVLIDFGLASHSNQDEDRAVDLYVLERAIGSTHPRSEPLFEALITGYRDSYKGASSALKKLEDVRLRGRKRSMLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W6PWA6</accession>
    <name>W6PWA6_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein-lysine N-methyltransferase EFM6</fullName>
            <ecNumber evidence="1">2.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Elongation factor methyltransferase 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">EFM6</name>
        <name evidence="3" type="ORF">PROQFM164_S01g001882</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that methylates elongation factor 1-alpha.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class I-like SAM-binding methyltransferase superfamily. METTL21 family. EFM6 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="1"/>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PWA6"/>
    <dbReference type="STRING" id="1365484.W6PWA6"/>
    <dbReference type="OMA" id="RRADMRF"/>
    <dbReference type="OrthoDB" id="407325at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03198">
        <property type="entry name" value="Methyltr_EFM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033684">
        <property type="entry name" value="EFM6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF152">
        <property type="entry name" value="PROTEIN-LYSINE N-METHYLTRANSFERASE EFM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="13"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="96"/>
            <end position="98"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM28071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="250" mass="27733" checksum="A078C082AFEBBC6D" modified="2014-04-16" version="1">MIEIPIPTLLGLPELSPPSSPDGLKISESLAPPREPKAAVTTDISFDGLLKEPLLLKEDLKDGCGGQLWPAGMVLAKYLLSRHITDLSDKTIVELGAGGGLVGLAVARACRLEHPIYITDQEPMFSLMKSNIQLNNLGPNATAAILNWGEPIPNQIPEKPDVIIAADCVYFEPAFPLLITTLQHLLGPDSVCYFCYKRRRRADMRFMKMAKRAFDMEPVRDDPGAESYNRENIFLYTIRAKRIDQKSDTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W6PWE3</accession>
    <name>W6PWE3_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g001932</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PWE3"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM28121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="72" mass="7582" checksum="9015E978CF908D98" modified="2014-04-16" version="1">MLGFSGKSGKGGSGEDQIESMMPRWFQKPTESPLGRTKGLKIWDIQYKEPQGVAIIGEGKKNSGGGGGGEVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W6PWK3</accession>
    <name>W6PWK3_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Molybdenum cofactor sulfurase, C-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S01g001992</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PWK3"/>
    <dbReference type="STRING" id="1365484.W6PWK3"/>
    <dbReference type="OMA" id="VYTACRT"/>
    <dbReference type="OrthoDB" id="17255at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005302">
        <property type="entry name" value="MoCF_Sase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005303">
        <property type="entry name" value="MOCOS_middle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14237">
        <property type="entry name" value="MOLYBDOPTERIN COFACTOR SULFURASE MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14237:SF23">
        <property type="entry name" value="MOSC DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_7G05900)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03473">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03476">
        <property type="entry name" value="MOSC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="PK beta-barrel domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51340">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="MOSC" evidence="2">
        <location>
            <begin position="260"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM28181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="428" mass="47917" checksum="FE6DCE6BBCB00A47" modified="2014-04-16" version="1">MSNVDISLGDDIVPNWFILFFLSVLFLSLKTLKTLTAPINPKGCRRLGLPPGQSNLDDEFDSKYSQGLPSNQDDHGRPSWRVKALFSYPLKSCGAVELQVSNVVPTGLEFDRQFVFAEYINDEWTIRTLRNASFNCLALIHPEIWVPDPSAPDYNADLSEVKSQGVMLISYPRIPPAGWKGLPIKLGMALKFLKSQRTFQVPLLPPADSKFPLVPVKIWKDKPLAHDYGRLLPASLHAYLGSDPSKKTLTLFRASAPHSRQIFRNAPRKEDLGFQPSTAFADAYPIHLLSISSHRDVAARCAYAIPRLSIRRFRANIIIQGPSAFEEDHWKRLAIGGTEIHASCRTVRCRLPNVDPLSGDRHNAEPDRTLKSYRRIDDGDRTNACLGMQLVPAKEEFVVRVGDSVEVLETGVHRYIKMLAPGEKVEGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>W6PYP6</accession>
    <name>W6PYP6_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Chloride channel protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PROQFM164_S01g000893</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the chloride channel (TC 2.A.49) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PYP6"/>
    <dbReference type="OMA" id="TDWVHDT"/>
    <dbReference type="OrthoDB" id="44789at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005247">
        <property type="term" value="F:voltage-gated chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03684">
        <property type="entry name" value="ClC_3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3080.10:FF:000013">
        <property type="entry name" value="Voltage-gated chloride channel (ClcA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3080.10">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014743">
        <property type="entry name" value="Cl-channel_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001807">
        <property type="entry name" value="ClC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45711">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45711:SF3">
        <property type="entry name" value="CLC CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00654">
        <property type="entry name" value="Voltage_CLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00762">
        <property type="entry name" value="CLCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81340">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0129">CBS domain</keyword>
    <keyword evidence="7 9" id="KW-0868">Chloride</keyword>
    <keyword evidence="5 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="185"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="267"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="377"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="400"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="428"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="502"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="542"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="602"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="625"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="11">
        <location>
            <begin position="858"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="66"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="104"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="309"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="35"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="80"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="323"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDM27084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="912" mass="99700" checksum="D8FE2FC4DB79A133" modified="2014-04-16" version="1">MPRSLPKSSFASREQDDTENVRVPQTAPPSPSIYRRSQSYLSETHTEYQSLDAPFEVTETTSLLGPAQAFRRRGPRRSYTSTSGVSGTGPDSFRHVLAAGSLRRTLNHSRANSMSRGFSRRGSMDGDSRPASLPPSMKDNLTASSFLDERTWYDQFTSTDWVHDSIADGARLRLLRQRKDVRGRLLAAFDGAQGWILVALIGCITASIAYFVDVTEGSVFDLKEGFCTTRIFRNRRTCCEGLAACDAWRSWSRIFSPSGTESQWVDFVIFVFWVVALALISCALTLLTKTVVPSSISLATLDENLGADPRGTKSGNGLGASDSPLSETETSPLHGTLPNYPSRPAMIYYSAAGSGVAEVKVINSGFVLHGYLGLKTLVIKTIGLIFSVSSGLSLGKEGPYVHIATCVGNICCRLFAKYNKNDGKRREVLSASAASGVAVAFGAPIGGVLFSLEEVSYYFPPKTLFRTFFCCIAATLSLKFLNPYGTGKIVLFEVRYLSDWQIFEIFIFILLGIMGGAAGALFIKASNLWARSFRRIPAIKRWPMLEVFLVALFTGLVSFWNRYTRLAVTELLFELASPCESDVESTGLCPRTDGILEIVQDLLVAFVIKSFLTIITFGIKVPAGIYVPSMVVGGLMGRIVGHLIQYWALRHPTFFLFDSCPAVAGIESCVTPGVYALVAAGATMCGVTRLSVTLPVILFELTGSLNHVLPFSLSVLCAKWTADAIEPRSIYDLLTDMNSYPFLDSKLQPTTDALLGDIVRPVRKNRIIDISASPFLPATDLRLKLEHLLMAGELDSGLPILRDGVLAGLIPAPDLEYALDTLGEEEENTICLMAMDASSAVLDSDNEDADEVDFSQFIDPAPIALDVHSPIDLVYQCFAKLGLRYLCVTRDGKYAGLVHKKAFVKFMKENSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W6PZ86</accession>
    <name>W6PZ86_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nucleosome assembly protein (NAP)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S01g003395</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the nucleosome assembly protein (NAP) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PZ86"/>
    <dbReference type="STRING" id="1365484.W6PZ86"/>
    <dbReference type="OMA" id="RFTFEFK"/>
    <dbReference type="OrthoDB" id="19419at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.90">
        <property type="entry name" value="Nucleosome assembly protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037231">
        <property type="entry name" value="NAP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002164">
        <property type="entry name" value="NAP_family"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11875">
        <property type="entry name" value="TESTIS-SPECIFIC Y-ENCODED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00956">
        <property type="entry name" value="NAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143113">
        <property type="entry name" value="NAP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="213"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="280"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="222"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM29583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="300" mass="34006" checksum="28F8CBC07282F942" modified="2014-04-16" version="1">MTPLIQKRSEIINIPDVQAEFWMRVFASAPPEIDEYILATDAQVLGECLKNMNVERFELDAQGNGEPRSLRFTFEFKTGDENPFFTNEKLVKEFYWRQEVSKNAAGKTRTWEGLVSEPVRINWKKDQDLTKGMLDAACDLAEAEKKKGGDRRKLPEFAALVKKVEEAEAEANEDDEDDEEPSPVGMSFFGFFGYRGRDVSAAQSKEAAKEIEARWAKIQNGEDIEEAGDSDSEDEEDDTEGVEEIDIFPDGDDLAVAIAEDLWPDALSYYVQSFQIGEELEDMDLDMEELDGDDSDEDMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W6PZC5</accession>
    <name>W6PZC5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Riboflavin biosynthesis protein RibD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g002892</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PZC5"/>
    <dbReference type="STRING" id="1365484.W6PZC5"/>
    <dbReference type="OMA" id="PTKFCVG"/>
    <dbReference type="OrthoDB" id="252265at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008835">
        <property type="term" value="F:diaminohydroxyphosphoribosylaminopyrimidine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11079">
        <property type="entry name" value="CYTOSINE DEAMINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11079:SF162">
        <property type="entry name" value="RIBOFLAVIN BIOSYNTHESIS PROTEIN PYRD, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18785">
        <property type="entry name" value="Inv-AAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="1">
        <location>
            <begin position="12"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM29081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="177" mass="19522" checksum="82E3E208F5F1AE48" modified="2014-04-16" version="1">MGSQANPAFTVGDHEAFMEFALLQAQKSPPAANKFCVGAILVDAANGKVLSTGFSLEYPRDYKGDPGTTHAEQCCFIKIADEHNLPEERIHEVLPANTALYTTMEPCNERLSGNMTCATRILRLKSAIKNVYVGIKEPGTFIAHNDGQERLEANGVRVMFPVEHWRDRITSVSMMGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>W6PZN8</accession>
    <name>W6PZN8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PROQFM164_S01g003546</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PZN8"/>
    <dbReference type="STRING" id="1365484.W6PZN8"/>
    <dbReference type="OMA" id="YIPFNAH"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11070">
        <property type="entry name" value="CYP56-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF223">
        <property type="entry name" value="CYTOCHROME P450-DIT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="461"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM29733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="508" mass="58064" checksum="58B84B7B77C90C34" modified="2014-04-16" version="1">MALALSSILLSILLIILLPPLLFLTWYLRVSRTLPNLPRIPIYVSILGLWSSMGQDEIYERWFRAPLEKHGAVLVWFAGRWSVLVSRPDWLTDMFRNEHIYAKAGSQIKIPHAVIATLVGDNIINAHGENWKVYTGIMKAGLQKKVFETTSLLKQSRKLVDVLIDLQKEVGANRGILIMADVQKWAVDVMSENFLDLDLKKTNPHQSLGQPNGAVRIEALQSIIKATLFKPMYFSFPDLDHFPWLFPSRKSAYNTMREFDNCLYTMIMAMLHKRTQINPTQSKDMVSHMLGEAYTSGRITEKQFRDNLKITFLTAHENAQQLVTSMFWQLGTRVDIQDRLREEILDTAKTHPNPSQEIINGLPYLTAVVLELLRLFPPVCQLINRVALRPALLGGELPIAKGTFVGWNAWAVHSNPDIWGEDAREFRAERWGESVEEMQGRFRRETVRGTYIPFNAHKRKCLGQGFALLQVKILLFVLLGRVSWVVDPAYRLKMTPVSVFLLGLDDVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W6PZW9</accession>
    <name>W6PZW9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g001315</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PZW9"/>
    <dbReference type="OMA" id="LVHTTNM"/>
    <dbReference type="OrthoDB" id="5419666at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="65"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="122"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM27504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="257" mass="28144" checksum="CCD5232F6BC09416" modified="2014-04-16" version="1">MSTLTRAFTRRNKRPEVSAPMPYRGEGNLRLNSASIKRSNISGPVQLLSTTNMLAYNAPDISPGYSAGSSSASSLGSRDDSDNAFSPQSYASSVSSPDVSPHGSSPIDANPLASYFPKHTASVTSHPRSSTSSSNTDAPMVPKRALSHTKRSHQELAHKRSVSRMSPPPLNAARTTPTIRASQEFFQAEPHPFGKELEQVNEVVEDFCGLNMHDDEERILYAKGLKKFSVEDYLVEVEELYGSIFEDTRGPMTTSWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q0C6</accession>
    <name>W6Q0C6_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Conidiation-specific protein 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S02g000122</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM29973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q0C6"/>
    <dbReference type="OMA" id="NEMRGYK"/>
    <dbReference type="OrthoDB" id="5419162at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018824">
        <property type="entry name" value="Conidiation-specific_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052670">
        <property type="entry name" value="UPF0654_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36576:SF2">
        <property type="entry name" value="PROTEIN CON-6, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G03615)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36576">
        <property type="entry name" value="UPF0654 PROTEIN C11D3.01C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10346">
        <property type="entry name" value="Con-6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM29973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="93" mass="10525" checksum="458B667133F29314" modified="2014-04-16" version="1">MSTTEERVNEMRGYKATLSNPRVSERAKQHAHDRLNELGGDKPREELFQARGDRKKDPTRVAAGYKAAQHNPNVTEAGKKKATEELHETVPEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q1K3</accession>
    <name>W6Q1K3_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PROQFM164_S02g000572</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q1K3"/>
    <dbReference type="STRING" id="1365484.W6Q1K3"/>
    <dbReference type="OMA" id="GDMYSLM"/>
    <dbReference type="OrthoDB" id="3357846at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015244">
        <property type="term" value="F:fluconazole transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990961">
        <property type="term" value="P:xenobiotic detoxification by transmembrane export across the plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF23">
        <property type="entry name" value="FLUCONAZOLE RESISTANCE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="164"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="200"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="261"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="295"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="368"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="407"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="446"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="474"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="506"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="541"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="134"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="48"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="68"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM30423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="579" mass="64609" checksum="00A772295FC4AD78" modified="2014-04-16" version="1">MESVIREAPFGQLVRLLTNNKYFQYPEEKPDFKLPDTWLQLLNSRDEGKQKNAIRHDSNRSHEHSEPLSRSSTQASMQFTEARLEADEEHEIEKVESIPIAPKRTKDGSILVDWYYTDDSENPHNWSNLKRALITIVICLYTFVVYTTSAIYTSSTEGVMNEFGVSTLVATLGLSLYVLGYGTGPLIFSPLSEIPVIGRNPVYIVTMFLFVIISIPTAFVGNFAGLMVLRFLQGFFGSPCLASGGASIGDMYSLMSLPYAMMAWVSAAYCGPALGPLLSGFAVPAKGWRWSLFESIWASAPVFILMFIFLPETSSATILLRRAGRLRKIHNNSRFMSQSELNQRNMHISDIAIDALIKPLEITIKDPAVLFVQIYTAIIYGIYYSFFEVFPLVYPADYNMNLGQIGLVFLCIMVSCIIGIAAYASYIHFWMHRRIRRSGFPVNEALLIPALPASFGPLIGLFLFAWTARASIHWIVPTIGITIYGATVFVVMQCIFMYIPLTYPRYAASLFAANDFFRSALACGSVLFAHPLFGNLGVARGVSLLGGLSVIGIIGIWLLYFYGSRLRALSKFAISDEVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q1R6</accession>
    <name>W6Q1R6_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Flavoprotein transmembrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PROQFM164_S02g000065</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM29916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q1R6"/>
    <dbReference type="STRING" id="1365484.W6Q1R6"/>
    <dbReference type="OMA" id="LPNTHED"/>
    <dbReference type="OrthoDB" id="4494341at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000293">
        <property type="term" value="F:ferric-chelate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000071">
        <property type="entry name" value="Cell surface metalloreductase (FreA), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051410">
        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361:SF26">
        <property type="entry name" value="FAD-BINDING 8 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="5"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="166"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="8">
        <location>
            <begin position="229"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM29916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="512" mass="58010" checksum="ECC416110AE8F99E" modified="2014-04-16" version="1">MEITIFYAIAVGCLLTTLFLIRIAPSFLNLLGILSFLITKHLTYPYLWGRYRLIAPCTRADALLYLAYAVTNVFLVAFKTPSTTMARDRAGTLSVINMSFLFLAHHLGFLANAMGVSLMACKRIHRAVGWMTGILLGLHIIMAMITDRKSWILREKPNLFVLISKEVIPLKGSVIIAAILLSSFPFIRRFLYEPFLRLHQALATACIYSIWRHLPSGALLPRLNGVFPPRPYSRASIRCDRVQQTPIQSKEATPLKVRIALTRPLHIQAGQYISLWIPAASLFSWAQTHPFMVTSWSPEKQDVLELFVQPRRGLTETIHHRTALDGYTSLTAFVGGPYGVSKSVDHYECVLAIATDFGIAGVISYLKKLLYGYNTCTSHVRRVHFVWEIQTLDIAVAAQPLLNSLLSDDILDDGYILEMSFFVASNQMIEHGKPFGQHRRATVFNGKPRYDEIISEEASGRNIKRLPNTHEDRGEVLVMVSASHEVRDRLRELVRKHLEQRVRLHETEFQPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q1S9</accession>
    <name>W6Q1S9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S02g000085</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM29936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q1S9"/>
    <dbReference type="OrthoDB" id="4481619at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM29936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="140" mass="15664" checksum="535EB04B28B9B5FD" modified="2014-04-16" version="1">MCAEQIPDFHCSPRYPGGVITANALSLYRQAHVLLCGNFRPLRSTLATRNVQTISSSLNDVKVEISGSSTCTRAAWCAIEALQTSVKMGMSQSASISGWHFKLLFNIYSLECCLFHRFWVRRQSIRARPDLSSPTEFSTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q1T7</accession>
    <name>W6Q1T7_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S02g000095</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM29946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q1T7"/>
    <dbReference type="STRING" id="1365484.W6Q1T7"/>
    <dbReference type="OMA" id="MIYATNG"/>
    <dbReference type="OrthoDB" id="3672617at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004879542" evidence="1">
        <location>
            <begin position="20"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM29946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="118" mass="12510" checksum="F92B3BB1FF4B7A9F" modified="2014-04-16" version="1">MQLWAYLLPVATIGQVAMAYSSNCEGSFVLDTDLVSIDKDCAKAISNIDTSATYNDGSQFSEGHCYLVYATNGSGDQPVSGQTIHDVAQSILDGCAKKHGSYGTGNCDACHVTVNYRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q392</accession>
    <name>W6Q392_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Six-hairpin glycosidase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S02g000595</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q392"/>
    <dbReference type="STRING" id="1365484.W6Q392"/>
    <dbReference type="OMA" id="NYPMAVK"/>
    <dbReference type="OrthoDB" id="6503935at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.420.10">
        <property type="entry name" value="Maltose phosphorylase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035396">
        <property type="entry name" value="Bac_rhamnosid6H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34987:SF2">
        <property type="entry name" value="B, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G05040)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34987">
        <property type="entry name" value="C, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G02880)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17389">
        <property type="entry name" value="Bac_rhamnosid6H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-L-rhamnosidase six-hairpin glycosidase" evidence="1">
        <location>
            <begin position="375"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM30446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="795" mass="89562" checksum="19848F5C35C02575" modified="2014-04-16" version="1">MVSTEEQKTIDELQANWIWVPNWTDSSNANTAGKIVHFTRNVILSSRPTKSILHFSADTRYKLYVNGKHIAVGPSRSSPLIWYYDTLDIAPYLQEGQNEIRFTVVRYFATSRSAIPFARTALPGLTVIGNIETDEGVVDLASSKNWRASADESIEFPTGLADDVFLHISERVVPTNPGPAVVPFAYKIKTLNGDIPPWNLRPRSIPMPESTPAVVKTIRACDSVIEVRDWTAFFATNHSIVLPASSTHTLEVQADVHSTAFLRWAFKAAKHTSQIRLKVTHSEGYELEPRSYPFFRSKADRLNASVGHIIGPYDEVTLNLPDTESVIYEPFWFRTFRLLRIEITVGPEPIELVSFAATQVNYPMAVKASWKEPGDAHSEQIWAVSIRTMRNCMFDGYSDCPFYEQLQYSGDSRSVGLFHYLLSGDDRLMRQAITNFAASITPEGLTQSRFPSQIPQLIAGFSLYWVLQVCDHHLYFGDTRFARGFIPRIDGILDFFDAHIDELGLVSGLPEVVWQYVDWVTTWGATDDHPDKGVPTSGRKSNRHTYFSMLYAWVLQNVAGLVRDVGRPGHAAEYEARAASLLGAIRAHCYDGQFFTDSTADVADELSYSQHCQVFAVICGAARAEDSARILTESFTNDRFSRCSYMMRFYAFRAFSLAGEDLYESFWERMWAPWRGMLANNLSTWEEDDVRQRSDCHAWGSVPIYEYCTELAGVQPVAAGSSKIFFRPRLRLAEALEAKVALGKDNLAMISWKLSGNEKIVELSLEKPAEVVSRLPGGKEEEHGVVDHLSFLFSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q3I5</accession>
    <name>W6Q3I5_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytochrome c oxidase assembly factor 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PROQFM164_S02g001030</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Required for assembly of cytochrome c oxidase (complex IV).</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 9">Component of 250-400 kDa complexes called cytochrome oxidase assembly intermediates or COA complexes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the COA3 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q3I5"/>
    <dbReference type="STRING" id="1365484.W6Q3I5"/>
    <dbReference type="OMA" id="WYTLNAV"/>
    <dbReference type="OrthoDB" id="10018333at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041752">
        <property type="entry name" value="Coa3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018628">
        <property type="entry name" value="Coa3_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15642:SF3">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 3 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15642">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09813">
        <property type="entry name" value="Coa3_cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome c oxidase assembly factor 3 mitochondrial coiled-coil" evidence="10">
        <location>
            <begin position="21"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF09813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDM30880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="72" mass="7978" checksum="648C323180D168C1" modified="2014-04-16" version="1">MATGIFNSTYYGKDYRAGAALLRARRPYLFKNTLTGFGLFAFTIAVYTYTLKAVGQEDFADVKVPDAPADKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q458</accession>
    <name>W6Q458_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA-binding HORMA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S02g001285</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MAD2 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1365484.W6Q458"/>
    <dbReference type="OMA" id="KEEQTWI"/>
    <dbReference type="OrthoDB" id="21254at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:zeta DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Mitotic spindle checkpoint protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.900.10">
        <property type="entry name" value="HORMA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003511">
        <property type="entry name" value="HORMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036570">
        <property type="entry name" value="HORMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045091">
        <property type="entry name" value="Mad2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11842">
        <property type="entry name" value="MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11842:SF10">
        <property type="entry name" value="MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02301">
        <property type="entry name" value="HORMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56019">
        <property type="entry name" value="The spindle assembly checkpoint protein mad2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50815">
        <property type="entry name" value="HORMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HORMA" evidence="3">
        <location>
            <begin position="32"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="129"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="231"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="231"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM31135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="287" mass="31351" checksum="920FB20E6C41CD61" modified="2014-04-16" version="1">MPIASESSSTTTTMTTFSAPVPATKSLPTNQSALAASFTNFLTVSVHQILFLRSVYPRATFLPVRAYNYPVRQSRHPKVCDYINDASIAVGTEILKGTITAVSIIISSLRTSQPLERYAFDLSGFPRAPPGEVNTTFEDRTEDPSNSGAPVSDRGPAPTSVDLEAQFRACLARLASACARLTPLPRDDEFSFTVCIEVREDALPPAGTTKEEQTWIVAEPGKVHLRSCTAPFSVSKQRNGNPQQSPPKVSNGRAKTVPVRRVEAGELRLELWVEEARQKFNEPVDSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q462</accession>
    <name>W6Q462_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ChrR-like cupin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S01g002750</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q462"/>
    <dbReference type="OMA" id="HDFWEEV"/>
    <dbReference type="OrthoDB" id="9970537at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025979">
        <property type="entry name" value="ChrR-like_cupin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12973">
        <property type="entry name" value="Cupin_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ChrR-like cupin" evidence="2">
        <location>
            <begin position="25"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM28939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="125" mass="13896" checksum="94D14E5A75730759" modified="2014-04-16" version="1">MPIHQKEFSTPPPHPPVGTPKDSPSALPWYSIAPGVWEFLLNGDGEHKAVLQWWEPNTVSAQTEPITHTYIEEVCTLRGGLEDLSLGQTWSIGAYAYREPGMKHGPYRATKDGCLQFVKVVPAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q4D2</accession>
    <name>W6Q4D2_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Rab-GTPase-TBC domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S02g001633</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q4D2"/>
    <dbReference type="STRING" id="1365484.W6Q4D2"/>
    <dbReference type="OMA" id="WQDYLRI"/>
    <dbReference type="OrthoDB" id="294251at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000026">
        <property type="entry name" value="TBC (Tre-2/Bub2/Cdc16) domain family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF20">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="2">
        <location>
            <begin position="767"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="213"/>
        </location>
    </feature>
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        <location>
            <begin position="226"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="278"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="371"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="448"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="540"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="966"/>
            <end position="989"/>
        </location>
    </feature>
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        <location>
            <begin position="11"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="39"/>
        </location>
    </feature>
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        <location>
            <begin position="40"/>
            <end position="52"/>
        </location>
    </feature>
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        <location>
            <begin position="197"/>
            <end position="208"/>
        </location>
    </feature>
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        <location>
            <begin position="278"/>
            <end position="291"/>
        </location>
    </feature>
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        <location>
            <begin position="376"/>
            <end position="396"/>
        </location>
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        </location>
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        </location>
    </feature>
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        <location>
            <begin position="551"/>
            <end position="561"/>
        </location>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM31483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="1076" mass="116296" checksum="09B3DA9E1397A1E8" modified="2014-04-16" version="1">MADSDTHSQRRSSSQASSASSRSRNAKIARAKMQKRHSGSSHTTTDLTSFPSLSPPDKSPILARGLSNTLFSDENRAESNGGVTNRGRKATLENLTTGLKSGRSALFADSVSTHDIPGALHLADDAHIERLVAGTGAVKMVRQFARDLAQRDAEISALRQRADARERELKRMLRDVSVSNQDIERRLYQLENPPGDRVSDAESTHSSDHAGQAYSSLNGLMSQAMEDTVGSRPHGDSAEAQATIRAQRSDNDRGSGVTDSGKRQSSIRGWQEYLFGSTNTSRKTSRASSVMSDVGEVGEEETERLRVPSNPAMRRKALDEQLFQPPDGPARNGPAKRIASTSVNGDDVSIHSRKSSRSLGSWTVKLFAGNTQSSKDASDTESIHNKPQLRRPDGDKSTSSTFSANSKGSMSAVAALKRINSNVSIANTGRSASGSSVQGKMNTPALRRNAAGSVSQGATSETTDRASTNLGPVEMDAILPMESKPPTLTPIYNNSQSGEFLTDRFGFIYDQHRKKRQREANTIKSGNRSLSITETLGHLRTDASDHEDDPEITKLRQDASETSRSLPDSPDDPESGGIAIRRWQDYLKMPSRPTELLSDTPCAGPIVSLTTAGESRSHSSSVSYDKDGALAVGSSAQPSASTSAITADSPEFAGLSSDQLKDTAARFTVAEMEPVKLLLEQLTDLHDTLQRDRTVRWNEFLRKVRAERRKEGEAAAAAATSDRSLAAVDTPEVSLADGEVVGIANLGNKGKVGRAKWREFRLLVLGGIPVALRAKIWSECSGASAMRIPGYYDDLVHGVGGSDPDPSVVAQIDMDIRRTLTDNVFFRKGPGVGKLKEVLLAYSRRNPEVGYCQGMNLIAGSLLLIMPTAEDAFWILTSMIEIILPHHYYDHGLLASRADQVVLRQYISELLPRLSAHLEELGIELEALTFQWFLSVFTDCLSAEALYRVWDVVLCLNVTSTINGSGPNASGTKESNDKSAKNAENGASGSGGGSTFLFQVALALLKLNEPQLLTTCSTPAALYTYINHQMTNHAISIDGLIQASEALRNVVRREDVVARRAVALQEMRELSSGAST</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q4F7</accession>
    <name>W6Q4F7_PENRF</name>
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        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">PROQFM164_S02g001375</name>
    </gene>
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        </lineage>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CDM31225.1"/>
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    </dbReference>
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            <begin position="1"/>
            <end position="186"/>
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    </feature>
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            <end position="348"/>
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            <begin position="33"/>
            <end position="45"/>
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        <location>
            <begin position="46"/>
            <end position="117"/>
        </location>
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        <location>
            <begin position="118"/>
            <end position="132"/>
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        </location>
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            <begin position="168"/>
            <end position="185"/>
        </location>
    </feature>
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        <location>
            <begin position="328"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM31225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="429" mass="47650" checksum="61C078D2060828A0" modified="2014-04-16" version="1">MTSLARNSSGGPGCGSPNKNNFGIRNPTKMHFQPSSVPNGPRSYQNNGGARNNRGNYNHNGNANSNNQWSPRNANPRNANANGNGPSPVPNGPRAYQNNGGSWNNRGNNNYNGNANNQWSPRNGNPNGTHDYNNQRDTSRDGFGNENNQRSSNYKGKNFNPNYKGKNYNPSFSRPAQANVGQARNGNRRRLAYRNQNENYNLDIHPSNIDVQMDDAPSDEPNDIEMPDAPALPDPVLPDPRIKALALGAVAIKEMVSPPLSNFQFNPHAFHQPDVHHSAFRPPEFRPPTFHPPAFHPKVISSPKLQGNPEYSGLANPALVASRKDNKSTSTTESHFPTSVTIHRPPNQPQDLWVPHIGYEPSQTGDNPPRVGRGRLHRQTTHHKHRLVLVQMAHRPRLQGGPDRGGKGFEWVHVQWRNDIKEAVLRVQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q4G6</accession>
    <name>W6Q4G6_PENRF</name>
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        <submittedName>
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        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">PROQFM164_S02g001385</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
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            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
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    </dbReference>
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    <dbReference type="STRING" id="1365484.W6Q4G6"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13391">
        <property type="entry name" value="HNH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HNH nuclease" evidence="1">
        <location>
            <begin position="111"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM31235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="344" mass="38640" checksum="5A446FDF69384FC1" modified="2014-04-16" version="1">MEKVDNYQPISRNDNTVRILRAFDNHLPADGRANFIRHLQSLQTNQDIHDHAESLVNGLLAPMKTLRSTPTISPRAGMEDSIENIASQSSGPLVRETRLKAECLKRDGNRCVVTKRVDFHFLSKSDTTTPGAITECAHIIPFSLATWRDERESHAKNIIWTNLIRHFPALETRISFSRDNINDTMNAMTMTRDLHFYFGHFYFAFEETQVPNKYRLQVYRPNAFSPPLPRTVKFVSRDPRYALPSPELLKVHAAVARIFHASGAADHIDKGFRDLGETSVLAKDGSTDVSAMLAVTSLGVLGSRTGNIQQTPATFSGPKAQSVSKVHSGLIEEEGTDEEYTVWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q4M7</accession>
    <name>W6Q4M7_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S02g001743</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q4M7"/>
    <dbReference type="STRING" id="1365484.W6Q4M7"/>
    <dbReference type="OMA" id="RLWSYRN"/>
    <dbReference type="OrthoDB" id="202545at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42044:SF2">
        <property type="entry name" value="DUF676 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42044">
        <property type="entry name" value="DUF676 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM31593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="425" mass="47827" checksum="3B756DADBC189D12" modified="2014-04-16" version="1">MTCPGKEDTPLPYTASPTKLLSSDLSLFISKLWALPGILRPLNLGHTRELDELYPSLRNASTVLTHVFLLVYQVAFLLSLPIMVICMAPGLWIIVYSAIAFTVNYSIVMLMLNSFQRVLVSQVSVVERPSHERERWVYINGIAAGHHWVQMNIDQLSYIFGRKVTAVHNRTAGIIFDLIECLIQRDFAYATGDIRRAYSLVKEAILDPECDKVVLLLHSQGGIEGGLVMDWLLDELPHNLLHHLEVYTFGNAANHFNNPRWTKLARPQGNTAPDLTPEFGQSIGHIEHYANEGDIVAQGGVLHFVEIPNRYMGRLFVRPHSGHLFNMHYLGNMFTLGPDMNVLDSNSFMDMEVEPWATAGINGYDGPPRRVGSTIARDEAFLPVALTVRRSPPNELDRVLRVKDFSRLWQYRNGGCPDGTETHTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q4P3</accession>
    <name>W6Q4P3_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UDP-N-acetylglucosamine diphosphorylase</fullName>
            <ecNumber evidence="3">2.7.7.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">UAP1</name>
        <name evidence="7" type="ORF">PROQFM164_S01g002966</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>N-acetyl-alpha-D-glucosamine 1-phosphate + UTP + H(+) = UDP-N-acetyl-alpha-D-glucosamine + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13509"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:57776"/>
            <dbReference type="EC" id="2.7.7.23"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; UDP-N-acetyl-alpha-D-glucosamine from N-acetyl-alpha-D-glucosamine 1-phosphate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UDPGP type 1 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.23" evidence="3"/>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q4P3"/>
    <dbReference type="STRING" id="1365484.W6Q4P3"/>
    <dbReference type="OMA" id="YFQVDNP"/>
    <dbReference type="OrthoDB" id="532420at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003977">
        <property type="term" value="F:UDP-N-acetylglucosamine diphosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04193">
        <property type="entry name" value="UDPGlcNAc_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000075">
        <property type="entry name" value="Probable UDP-N-acetylglucosamine pyrophosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.10.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039741">
        <property type="entry name" value="UDP-sugar_pyrophosphorylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002618">
        <property type="entry name" value="UDPGP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11952:SF2">
        <property type="entry name" value="LD24639P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11952">
        <property type="entry name" value="UDP- GLUCOSE PYROPHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01704">
        <property type="entry name" value="UDPGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM29154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="506" mass="55551" checksum="DB7314258F7AB641" modified="2014-04-16" version="1">MAGVIKDAINNVLGHFHGTTPEVPREPSAEEFQALQKKYTDAGQGHVFTFVDELTPVEKSQLFHQLSNFDPARINELADKALNPPPAEQGTVTLEPLPEVATASILDSDPSDIQQWYEAGLKEVAANKVAVVLMAGGQGTRLGSSAPKGCFDIGLLSQKSLFQLQAQRILKLQSLIGGQDVVIPWYIMTSGPTRKPTEEFFEKNNYFGLDKSNVMIFEQGVLPCISNDGKILLETKGKAAVAPDGNGGIYQALVVSGVREDMRRRGIEHIHLYGVDNCLVKVADPVFIGFAASKNVDIATKVVRKRNATESVGLILLKNGKPDVVEYSEIDKETAEAKDPKQPDVLKYRAANIVNHYYSFRFLESIENWAHQLPHHVARKKIACVDTATGDIVKPEKPNGIKLEQFVFDVFPMTPLDKFACLEVHRHDEFSPLKNARGTGEDDPDTSRADIMAQGQRWVEAAGAIVITDGEAVGVEVSPLISYGGENLEFLKGREIKAPAILEREE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2024-10-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q4X4</accession>
    <name>W6Q4X4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S02g001859</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q4X4"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM31708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="53" mass="5740" checksum="D0660B20EC4F367D" modified="2014-04-16" version="1">MSQIGIARTGLSRDVATGNSLSGELPVLEEKQFYSPSIHVAPFDRVLVIDPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q4Z2</accession>
    <name>W6Q4Z2_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="7">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">pphA</name>
        <name evidence="10" type="ORF">PROQFM164_S02g001555</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the PPP phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="7"/>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q4Z2"/>
    <dbReference type="STRING" id="1365484.W6Q4Z2"/>
    <dbReference type="OMA" id="EGYNWGQ"/>
    <dbReference type="OrthoDB" id="1930084at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07415">
        <property type="entry name" value="MPP_PP2A_PP4_PP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000003">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047129">
        <property type="entry name" value="PPA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45619">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="9">
        <location>
            <begin position="134"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDM31405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="329" mass="37665" checksum="C64D59B384E283D7" modified="2014-04-16" version="1">MDNNMEIDTARSPEPHHLSPTSDPGSIPTLDGWIESLMTCKQLAEEDVRRLCDRAREVLQEESNVQPVKCPVTVCGDIHGQFHDLMELFRIGGPNPDTNYLFMGDYVDRGYYSVETVTLLVSLKIRYPQRITILRGNHESRQITQVYGFYDECLRKYGNANVWKYFTDLFDYLPLTALIENQIFCLHGGLSPSIDTLDNIRSLDRIQEVPHEGPMCDLLWSDPDDRCGWGISPRGAGYTFGQDISEAFNHNNGLTLVARAHQLVMEGYNWSQDRNVVTIFSAPNYCYRCGNQAAIMEIDEHLKYTFLQFDPCPRAGEPMVSRRTPDYFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q534</accession>
    <name>W6Q534_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">cAMP-dependent protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PROQFM164_S01g003096</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.11"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.11" evidence="1"/>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q534"/>
    <dbReference type="STRING" id="1365484.W6Q534"/>
    <dbReference type="OMA" id="CFDDYPE"/>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005952">
        <property type="term" value="C:cAMP-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004691">
        <property type="term" value="F:cAMP-dependent protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd05580">
        <property type="entry name" value="STKc_PKA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000822">
        <property type="entry name" value="cAMP-dependent protein kinase catalytic subunit, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000210">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353:SF37">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-DEPENDENT PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="70"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="12">
        <location>
            <begin position="331"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDM29284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="390" mass="44688" checksum="DA17CBE0F9644F9B" modified="2014-04-16" version="1">MATGAVQHSPNEAPGTMVFPKVNGNLHHRDKQLVESFRPPPRSSNPFLITERQDEKQLCISSRSLRVSDFVLVKTLGTGTFARVWLARLKDQKDKSKVYALKILRKADVIKLKQVEHVRNERKALAAVIDHPFITTLIASFSDEKCLYMLLDYCPGGEIFTYLRRQRRFSEEVSTIYAAEITMTIEFLHDVHGIAYRDLKPENILLDADGHLKLVDFGFAKQVDNRETYTLCGTPEYLAPEVIQNSGHGLAVDWWALGILIYEFLVGQPPFWDQNPMRIYEQIIEGRLRFPPNMPPAAQNIISLLCKTNPSERLGHISGGSTRVKSHPFFQGIIWDDLFYRRVKGPILPRLSHPADTGNFEEYPDPPDLRNTNIYTEDLKKKYEVLFSDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q590</accession>
    <name>W6Q590_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major facilitator superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PROQFM164_S01g003166</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q590"/>
    <dbReference type="STRING" id="1365484.W6Q590"/>
    <dbReference type="OMA" id="GYWKDRW"/>
    <dbReference type="OrthoDB" id="5086884at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050930">
        <property type="entry name" value="MFS_Vesicular_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23506">
        <property type="entry name" value="GH10249P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23506:SF35">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="26"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="69"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="157"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="186"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="272"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="299"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="337"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="368"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="422"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="445"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="31"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="218"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="219"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM29354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="487" mass="53321" checksum="EFF162B21630831F" modified="2014-04-16" version="1">MHPLPVPKKHVSWQTWGYHWRSSDTFILSSMSMALFTDEMLFAFMVPLLPYIFENRLELDTSLTQRLTSLFLVEGALISIISSPFVGNIADRASSKKVLLLVLLVLTLISVLCLSITTSLTWLLIGRFFQCIVSNALFIVGMATMTENIGSEHMGKIAGLSTTIVAAGTCSGPVIAGFLFGIGGYWTAWAGAALFLVVDIIMRLLMIEKPQKRRETACQDRNSSESLCAEEQTPSSETEPLLDAGQSSSTEEIGGWSFYVCLFRQRRFTAGVTCYFVFALFIACFESTIAMHVRYAFGWGVFPVGLLFASIQGPGMVLAPLVGYLKDRVGSRVPTTIGFLSVAPFLWFLGVAGDERFPWATLGTRGKIIYAVCTTMIGCFMCLLMGVGTMEATATVDELEDLHPGVFGPYGGYSRAISITNMSWMSGLLVGPILAGFMVERFGYFELQCVLVVISLLASANAAFYLRPTSPRKGECNTSEFGTDEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q5B9</accession>
    <name>W6Q5B9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PROQFM164_S01g003201</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q5B9"/>
    <dbReference type="OMA" id="GGSIWPW"/>
    <dbReference type="OrthoDB" id="6770063at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
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            <end position="87"/>
        </location>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="288"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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        </location>
    </feature>
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        <location>
            <begin position="394"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="443"/>
        </location>
    </feature>
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        <location>
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        </location>
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    </evidence>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2024-10-02" version="15" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1">FM164</strain>
        </source>
    </reference>
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        <source>
            <dbReference type="EMBL" id="CDM31191.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="62" mass="7207" checksum="E6B0B107A325F8D0" modified="2014-04-16" version="1">MASTPELTDFPSVYRGYGKRCRIRRDDLKVRGRFPVSEKSTPWQEIFQSETGRLNEIMVLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q6Q5</accession>
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    <protein>
        <submittedName>
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        </submittedName>
    </protein>
    <gene>
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    </gene>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
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                <person name="Abraham A.L."/>
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                <person name="Conseiller E."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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        </location>
    </feature>
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        </location>
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        <location>
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        </location>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM32030.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="236" mass="26531" checksum="D48340086164AFB9" modified="2014-04-16" version="1">MPKTNKDIEQQIQLAMDSLSDQSKPNIRKTAREFAVPEGRLRRRWRGGKSLFERQPNGRKLNPAQEKALCAIIASFPAVGSSITRRQITDAADSILKDGHNDPTTEPPRIGDHWLKRFLKRNPNLFPTELESSNPHDDNPPRPDTPSVSSEDTEFSTPKTAEEIRRISDRLNRTDPNTQRFKDGLAKLAKGAEAQATLALQLQRELDRTHAIMGARNARYDAPRRNIPIAGIINSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q6T6</accession>
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    <protein>
        <submittedName>
            <fullName evidence="5">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
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        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
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        <lineage>
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            <taxon>Aspergillaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
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                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="ZAR1/RTP1-5-like_Znf-3CxxC"/>
    </dbReference>
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        <property type="entry name" value="Zn_ribbon_3CxxC"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="zf-3CxxC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="3CxxC-type" evidence="4">
        <location>
            <begin position="88"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDM32065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="204" mass="23811" checksum="8E4B2F191AF26432" modified="2014-04-16" version="1">MGDTDELELFRRRWREELLIESDRRASPAAALASTAPPRTKKKMSITTCSMYQDLHDEVSSLLAEVDLHYQFFEEDDETKCTRMRDTNIMGRFVCNQRACKSKGWSSNKIAVTIRLYPEQKYNARVYHQRCKACSSLSRPVLDQSYAERIVYWIKQWNGIRVERPPFSHERRGPHNSQLCEGCRAGHCSQSGEDWAIRLEMLTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q7B8</accession>
    <name>W6Q7B8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Two pore domain potassium channel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PROQFM164_S02g000308</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q7B8"/>
    <dbReference type="STRING" id="1365484.W6Q7B8"/>
    <dbReference type="OMA" id="IRYTWHE"/>
    <dbReference type="OrthoDB" id="297496at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015271">
        <property type="term" value="F:outward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022841">
        <property type="term" value="F:potassium ion leak channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030322">
        <property type="term" value="P:stabilization of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003280">
        <property type="entry name" value="2pore_dom_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003:SF301">
        <property type="entry name" value="POTASSIUM CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003">
        <property type="entry name" value="POTASSIUM CHANNEL, SUBFAMILY K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01333">
        <property type="entry name" value="2POREKCHANEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5 8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="166"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="208"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="264"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="360"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="390"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="421"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="11">
        <location>
            <begin position="213"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="11">
        <location>
            <begin position="370"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="493"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="496"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="506"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDM30159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="641" mass="72632" checksum="EE1DBBD2308ABCF5" modified="2014-04-16" version="1">MNEPGFDDAIADEAVALDRTASSPNQKIDEINKLSQHDTEYQQAARWWLASTAYPLVAGTFGPMASAFNICSLSQPWRMDLTSSGGTDIPDPKWVTAINAISLVFALVANLALSLTMARRIRFEIAQPIIVVGWYISSAFLIAILIPFGVNMYKPENNGRIYSQSYYYGTFAAGLYFIIASLMAVTGYGAYRGYSSRKFNLTTSQRTLMLQTIIFCFYLLGGAAVYSKVEGWRFLDAVYFADYTLLTIGVGNFSPSTHLGRGLLFPYAIGGIIILGLIISSIRTLMLENGKQKIGNMLTAQTRKYLLREAFSDRSGAKGIIPSLGKKSAKAEGRSEREQRKREFIAMRQVCKLANVQHKWLSLLLSFLLWMTIWLIGGVVFWRSESNAKWSYFEALYFAYTSLLTVGYGDLYPISSLGKSFFVFWSLLAVPTITILISNIGDTVIRFIRDVTLFIGELTILPGDHSFVDRLKTLTHISWVRWWMEETTGEKEGAQQHAQFSQNQDPNKENGNDFDFKNNKEEKQAENIHQYIYLLFRELRKIIEYASNTPSRKFDYLEWEYYMSLIEGDNKPKVLGDEANDGQAQAAREWSWTDQENPLLAETSEVQWLLGRLTEVLDRELRRASQVHHVSERAKGDGAED</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q7D1</accession>
    <name>W6Q7D1_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein kinase-like domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S02g002789</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q7D1"/>
    <dbReference type="STRING" id="1365484.W6Q7D1"/>
    <dbReference type="OMA" id="ENDWYLY"/>
    <dbReference type="OrthoDB" id="2906425at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05120">
        <property type="entry name" value="APH_ChoK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF58">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="209"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM32638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="437" mass="49660" checksum="94E09B56979BA3E1" modified="2014-04-16" version="1">MGDTPHPEALSLSNADAAQWNRDLILAFQAELERNPEADLMSMFSDSYRLEHRNSQYRQLSYPAEINLRTLHELRDTLRDEPEVNVLSKFPTNYNRKITMATGPKVLPLVEKDAPEVQAPEFRTRLDLAETATVIFPLSKEVVALLAQFSEYALEVGSSDNGKALVVPLKQLLWNSPKLWENPVRGVVVKCNDDIVAKVILGNRDYTEYTSMEFLAERAPDIPAPRPYGLIAFGPFRVIFMSYIPGTTLAQAWPVLSHEGKLSIQQQLEDIFCRLRSLQQDEGKALGGVRGEGAKELRVDECALFKGITTAMEFSNLQFSARHHGSNTYVTLLRSLLHHDSPDMAHRLVFTHGDVRVDNIMVTKDRNINGHYIVTGIIDWEDSGFYPAYYECTTLTRTLSLVDEDDWFLYLPESISPSKYSIRWLVDRLWGIHVRST</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q847</accession>
    <name>W6Q847_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S02g002706</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q847"/>
    <dbReference type="OrthoDB" id="545169at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050151">
        <property type="term" value="F:oleate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010354">
        <property type="entry name" value="Oleate_hydratase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06100">
        <property type="entry name" value="MCRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM32555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="60" mass="6775" checksum="1098D468FA76BF62" modified="2014-04-16" version="1">MPRKSTTFLRRDYYDRPKVIPDGMRNMAMVGSSSLFLVKCLLVWTIACVGQTIDHPMGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q952</accession>
    <name>W6Q952_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S02g002687</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q952"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM32536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="59" mass="6538" checksum="A686B8BA3B9A26FD" modified="2014-04-16" version="1">MAIFPSFKNDASPGEIHDIVMNILQTFVSSILALTLLNFFSEAFRLLRAALGLMGYAIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q973</accession>
    <name>W6Q973_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Pheromone-regulated membrane protein 10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PROQFM164_S01g000096</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ThrE exporter (TC 2.A.79) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q973"/>
    <dbReference type="OMA" id="QHFIFVP"/>
    <dbReference type="OrthoDB" id="413008at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010619">
        <property type="entry name" value="ThrE-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051361">
        <property type="entry name" value="ThrE/Ser_Exporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024528">
        <property type="entry name" value="ThrE_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31082:SF10">
        <property type="entry name" value="DUF1212 DOMAIN MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_3G01440)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31082">
        <property type="entry name" value="PHEROMONE-REGULATED MEMBRANE PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06738">
        <property type="entry name" value="ThrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12821">
        <property type="entry name" value="ThrE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="505"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="529"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="590"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="626"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="669"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="695"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="718"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="750"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="799"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="domain" description="Threonine/serine exporter-like N-terminal" evidence="8">
        <location>
            <begin position="397"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="domain" description="Threonine/Serine exporter ThrE" evidence="9">
        <location>
            <begin position="676"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="154"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="222"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="277"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="26"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="53"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="294"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF06738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDM26287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="837" mass="91484" checksum="3A6EC4CE3BF509C2" modified="2014-04-16" version="1">MSGIINPHPSPSEEYAEYPLPIIDNPGDRHSLEREATVDVNQYNAGIEPPTRRGSRSHHRVRFRSMSLRRNENDSDPLSRPLLPQSDLNEIPLSGTITPPAPAHSGRGSNVHMPEFDETEKHDFTGKMDRATSARDRFRATGHLLRQKTSRLTERLGRPTDEGEPLNASYNPDDFDSGIPLEELQARRARHEADRAHALESGENFIEPPPSAEAHRLVRSMTAVQDQLRKRKPRGAYQRSGQTTPEGLISAFTQRRRSSGVGGGILSQLLKLQVAQSGSSSRPESVITDDSDSDTQVSSSISTPKKGYISPLIPASQPASGAATPRKEKLKWYKKSAHRSTSSLVNASMNLSTASLPAAVEAAPGMQKKRGKSKRKTRLEDEIRVTVHIAEIIARQRYIMQLCRALMRYGAPTHRLEEYMQMTARVLEVSGQFLYLPGCMIMSFDDPTTRTAEVKLVRMVQGVDLGRLADTHNVYKNVVHDLIGVEEATQELDEIMQRKPRFSKWILVLVYGFASAAVGPFAFKARPIDMPIIFCLGCIVGLMQHVLAPRSTLYSNVFEVTAAILTSFLARAFGSIMVTRNGKSEPLFCFSAMAQSSIALILPGFMVLCSSLELQSHQIIAGSIRMVYSIIYSLFLGYGITVGTTIYGLMDGNATSASTCSGLDVYGSVYARTFPFVAVYAIFLAIVNHGKLKQMPVMVFIALSGYVANYFSTTKLGAQSEVANTVGAFTIGVLGNLYSRLWHGHAATAILPGIFVLVPSGLASSGSLIAGIKYADEVRQNLENNGTSSYSSSLSETSVASLGFGMIQVAIGITVGLFIAALVVYPYGKKRTGLFSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q9Z0</accession>
    <name>W6Q9Z0_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S02g001144</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q9Z0"/>
    <dbReference type="STRING" id="1365484.W6Q9Z0"/>
    <dbReference type="OMA" id="KMHWSPR"/>
    <dbReference type="OrthoDB" id="5311681at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="371"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="575"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="578"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="623"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="650"/>
            <end position="661"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM30994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="720" mass="79746" checksum="CB4E0B4582556EA8" modified="2014-04-16" version="1">MATVNRNMFGASITEPPGGAQLMALPLNLIAEIVSHVDDTGDLARLCRTCRVLNYMALPQLYRSLTLTSYDKIRYRDEQPEGIGSASPFTMGLNAIITRSYATLVRSMTLRGEWKEYELEEHAQVGRVPDASMLLNIAARAAIDRMTNLESFHWELNTKMLDTVFLGLTQLPKLTSLTIRFPSSRHPQPTFVIPGMPHLRCLKITDIDPLCYPDDISTLLYKSRKLRELKLHWSPRMRDAHEPSVSLHDYFRKLIASKQPLAVKKMTFQNLYAFHTEEFNWAFDPTTVEDVTFLSGLDGSSLVNTFVENSWPTVPPHAKLRMKSIRMDAVSKRSAEFIGNFSGLERLYFVNVTSESSDILNCPRPGGGVVSSALTPPVSEHHSSGAPGGTTANSPITSASPASQLNAIASMRDIYLSNITTNHGATLRHLLLPSKWPLSTGMVARLVHSCPNLEQLALATEFSSMDSLGLLIPFLRKLKAIRLLIPPPTGQASGGPATSALKIYPSARFDSIKMVQETFANAKTFAEVVDIDDSILTEMLSYDLANKQVYGNVKIISMGWKAWELKDFYKAPIPLGTNKESQTPNGDNASPETTTDSSAPTQGTDGIGPSAPYQPAVSHKSPDTQTTHISSWSKSPGTRPILPPSTLGKRSRDLDGCETHRPPPCPRTPNRAEDNEGVPVYGCYPHTFTDDGFVWKRRARRVGWEVLQHWEVWALDSQEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W6QAJ0</accession>
    <name>W6QAJ0_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RNA polymerase III Rpc4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PROQFM164_S02g001324</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QAJ0"/>
    <dbReference type="STRING" id="1365484.W6QAJ0"/>
    <dbReference type="OMA" id="LQFPPMT"/>
    <dbReference type="OrthoDB" id="5836119at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007811">
        <property type="entry name" value="RPC4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13408">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13408:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05132">
        <property type="entry name" value="RNA_pol_Rpc4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="164"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="375"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="447"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="54"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="86"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="137"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="164"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="236"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="268"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="323"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="375"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="386"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="407"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDM31174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="575" mass="61898" checksum="7C930B04A284087C" modified="2014-04-16" version="1">MPPKAASRGSARGGAANRGARTDTTTPTPAGGDTTQNAPTATSAPGPASRASVQRLQSLNKRTPSGSIAPSSRPPSALGGEPAKPVMKHKPKAVGRRSKQERDEIERLEQERYNERLKEAAAIQRGRGGTARRAGFRGRGGPMAMGMSGFGGRGGKLGRGGYGGGSGGGYGGSAGGAGSGYNRSGLTGVNRGRAYDSSDDEENALRVSIDHINLDSDEEDWDTPKDFKGKQPSRSSGERGLRPVRVERHEHEERVISVNMESSTSRTADLRKKAEKEKAAKDVGRTPTKVKPEPRDDDTTMPDAIPHADDDDLLPEHNVRVRSAQSMSPTKRSTTELRSIQPTPEPEIPDPRSLLHTKEEIDEYDRHMEDLAIIKDLLVPKESKNATTEAETTEGAAEGKPAAVEGQEGDQPNEEKEEEQEEDNPLHGQMFLMQFPPMTPYLRVAGSSQDNQHQAAATAPPPNEIKREAGDDVEIVGSTQATELKENSVITAGHPWSLPTGRVGKLNVHQSGRVTLDWGGISMELDRGAPVGFVQEAVILSKVPPESEEDIPKHVWSMGQLSGKFTVTPNWDEML</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W6QAL8</accession>
    <name>W6QAL8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tetratricopeptide-like helical</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S02g003227</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM33076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QAL8"/>
    <dbReference type="STRING" id="1365484.W6QAL8"/>
    <dbReference type="OMA" id="KWMKRAT"/>
    <dbReference type="OrthoDB" id="272077at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051726">
        <property type="entry name" value="Chitin_Synth_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46430:SF1">
        <property type="entry name" value="CHITIN SYNTHASE REGULATOR SKT5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46430">
        <property type="entry name" value="PROTEIN SKT5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="200"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="654"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="22"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="51"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="250"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="657"/>
            <end position="666"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM33076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="701" mass="77228" checksum="9EE0FBACF8799187" modified="2014-04-16" version="1">MASPAPGHRQALPSPPPAYLRSSPSFTPSETPRTIPNRPQKLNLSKPAHQASRSETSLVIQHSPRSPVKIAHSADIPDASSVRIEGAYSGPTTPQLDLPEFTDLSLDDPVQPPQHTWNPAHPQRRDSSQAHYTHSNSYGHTPASSGSWSVIDPKDDGHGNKKSRPSLERAGQSHNGSSRESLDSVPLVEDNYEPLAYHHQQPAAAVTRKPAPNGDNPSASTDKLAVRRTRLSRPVSAYSSTSDGRHRRNLSASPYLNARSSSGTPETRSLSFLNLLNTSYPQPGPTTQFDNSRLQASVGNNASLLSHKETFEMYLANVKKTDEPTVLYEFAVFMVNSMREMPPVDVEDSSPITRARLLRESKSILQRLADRSFPFAQYYLGDGYASGLFSKGVEDYDRAFPLFLAASKHGHVEACYRTALSYEFGWGCRVDGSRAVQFYRQAASKNHPGAMIRMANACIAGDMGLGKRYREGVKWMKRATESADAQYNSGPYELGVMHERGFGDDVFPDATYAAQLFTKSAELGHVEACYRLGDAYEHGKLNCPRDPALSIHFYTNAAQNGHPLAMMALCAWYLVGAEPVLEKDDNEAYEWALRAANLGLAKAEYAVGYFTEMGIGCRRDPLQSNVWYVKAADQGDERAKHRIATIRAAAEGKHPAAARNAATRSTARLKKAERKAQATSHVQETEDEIDKPAKQKRFVIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W6QAU4</accession>
    <name>W6QAU4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aldolase-type TIM barrel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S03g000512</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QAU4"/>
    <dbReference type="STRING" id="1365484.W6QAU4"/>
    <dbReference type="OMA" id="FGWPEEY"/>
    <dbReference type="OrthoDB" id="2349068at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018580">
        <property type="term" value="F:nitronate monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04730">
        <property type="entry name" value="NPD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004136">
        <property type="entry name" value="NMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332:SF34">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE FAMILY, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03060">
        <property type="entry name" value="NMO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51412">
        <property type="entry name" value="Inosine monophosphate dehydrogenase (IMPDH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM33788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="350" mass="37572" checksum="CB7579191E170A25" modified="2014-04-16" version="1">MAASLLSRYPWVSTPFVVSAPMKVMSGPALAVAVSRAGGLGFIGPGAKTQDTSDDLEKASSLIHQEAGIKPTPGSTLPVGIGYQLWADDINVAVAAIEKYKPCAAWLYAPRQGPKEYDDWSRKIRQVSPDTQIWIQIGTLKEAKELLLNSERPDVIVLQGAESGGHGRAKDGMGLMALFPEVADAMSGSQIPLFAAGGIADGRGVAAALCLGASGVVMGTRFLAASEARISQGYQDEVVRAVDGAASTTRTLLYNHLRGTFGWPEQYSPRTIVNKSFVERQEGKPFEELRRLHDEAAKTGDNGWGPEGRLATYAGASVGLIHGVKPAEDIVREIREYALERIQRLCPRKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W6QAV4</accession>
    <name>W6QAV4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Peroxin 11C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PROQFM164_S02g001404</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Peroxisome membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QAV4"/>
    <dbReference type="STRING" id="1365484.W6QAV4"/>
    <dbReference type="OMA" id="PLCVHWS"/>
    <dbReference type="OrthoDB" id="10005898at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008733">
        <property type="entry name" value="PEX11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12652:SF25">
        <property type="entry name" value="MICROBODY (PEROXISOME) PROLIFERATION PROTEIN PEROXIN 11C (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12652">
        <property type="entry name" value="PEROXISOMAL BIOGENESIS FACTOR 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05648">
        <property type="entry name" value="PEX11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="1" id="KW-0962">Peroxisome biogenesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00046271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDM31254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="304" mass="33496" checksum="ED17E88C6D16C87F" modified="2014-04-16" version="1">MSDPEHLPGEATDAPPGQAPARSSCAKRQLLAALTTTDVTIRRLDLLLSEANGQERVLATINYVASMLHHLTASAPWIALQTKLGILARLKGRVPTKNVTPASSKSKFAALSSLASETRYNLRLFGLLPLWIWGADTLKSPPADPILHALTVLQVISNVIYQLLENVGYLASKGVVSKRFVDKYGGVAKWEIWSTRGWFGHIFFQFFVLWRQSVLRRQRLAAQRAAAGTVETKETKAEDSEALRLEIRAWRKSMVNNVIWAPLCLHWCLEKGIGIPDSLTGLISFCAGAWSLHDCWAGTASVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W6QAW7</accession>
    <name>W6QAW7_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">F-box domain, cyclin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S01g000666</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QAW7"/>
    <dbReference type="STRING" id="1365484.W6QAW7"/>
    <dbReference type="OMA" id="WMIPVVF"/>
    <dbReference type="OrthoDB" id="5279008at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="362"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="432"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="370"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="437"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="472"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM26857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="665" mass="75899" checksum="F3EAE9681433CDBA" modified="2014-04-16" version="1">MSIAALPVELISKIYDHLDYQELVALRLSCRALYKSSLENFAKTFYRKICFIATNESLHELEELSKSNGLREHVQELWMIPVVFDGAEGPLGMISISSKSCRQVKGDELESRRTVQKDMIADNRNLLESEAFSDRLRECMDRFKNIQTIGLAHYRTEFLLDPRQQTVPFLGRRQMMSQIDFRFDVYSLQESMRTNKASQIRKLNSLALSKLFLALCGSSCRPRKLSTCDSKFCYDIGPRIALSEEQLDSLLSTLEDLEDLHLCIDLNEAAWLKLFRKLGPQLEVLTLSQDHMPFYLIQDDMHAYPAKGYVGNMFHDIGFTRLRKLHINKLDINFSSLRSLLLSVKKSLVTLTVRRVTIGSEESGATENPRSQDAESPDRQENERSVRYTSPSYQPTVLPYQPTLPSYGPTVPSYQPTLPSYGPTVPSFQPTLPSYGPTVPSFQPTPPSFSTSSPYTPTVSPQEYGPAPLSVLPASETASAESAPQSPQLSSTSDSSEASTEEYWSRKWMSTYHPYEPSETAGGFVCPTRETVMAWERNEEKITSMPSFLDILRNELSLETLSLEDIICDGNYYDFERIDTTDKQRGKVDFDIRKANISLKDWISRLRPIARCPADRIIKYKEDEEMEDWFDKMIGKDSGSFTRLDCDCKRKKKPTWGCPFGCYRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W6QB13</accession>
    <name>W6QB13_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ankyrin repeat-containing domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S03g000379</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QB13"/>
    <dbReference type="STRING" id="1365484.W6QB13"/>
    <dbReference type="OrthoDB" id="2980193at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM33655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="93" mass="9946" checksum="28E851B04BF76C28" modified="2014-04-16" version="1">MPYKLTREDVAWGIEESAAIRAAGNSNPAVLHALLDYHKRTLRELAGCSPNANVSGSNMGTYESPLTAAIRVNSPEKVRMLLASGADPMGIHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W6QBJ4</accession>
    <name>W6QBJ4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S03</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S03g000125</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QBJ4"/>
    <dbReference type="STRING" id="1365484.W6QBJ4"/>
    <dbReference type="OMA" id="GTFSRCF"/>
    <dbReference type="OrthoDB" id="2103031at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM33401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="302" mass="34426" checksum="FE90C60A82EA62B2" modified="2014-04-16" version="1">MGWLWGDKNDTVQKLDPGLRDYLEQEKPDKYVPGPNVKPPSTPAQSPEPSDPSKPKVPAASLYPDGRYAYLWKTYKPPMDLEEQPGVGVASRVIEKYKERGDTVQRAAMENCALEHEALTYCFQTGNWRKQIEARLTMCSAENATFSRCFMTQTKLLQALGYASSFEYDAEKEERIQMHGDKLYHQMLDYEKRVDDAKAAGIAPPPITSLFNPDKPSQTPEVGLEIPGGEPIPAELKPSKPLEKLTPHERELEIRAHYAQREQHKMYAEEAAPFIKSQEDARQKRQERAVSWFGERLGKWLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>W6QBZ1</accession>
    <name>W6QBZ1_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Zn(2)-C6 fungal-type DNA-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PROQFM164_S01g000976</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QBZ1"/>
    <dbReference type="STRING" id="1365484.W6QBZ1"/>
    <dbReference type="OMA" id="SGFWIRT"/>
    <dbReference type="OrthoDB" id="10251155at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052073">
        <property type="entry name" value="Amide_Lactam_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47171">
        <property type="entry name" value="FARA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47171:SF2">
        <property type="entry name" value="TRANSCRIPTION FACTOR, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="4"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="43"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="44"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM27167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="629" mass="70022" checksum="A908BFC41A607BBA" modified="2014-04-16" version="1">MSTACIICHKRKVRCDFATHDPCTNCKKSDVECRPYTRKRKRFTNSLSPGRNVSTSAPLSQTPRSSQVPPESPEAQVASQRNYLSESHEAIPIETNTAVIANNGEPFIKEESYRGRSEYIGGSVPFDENMVKPGRETTYTSPKASATDLKMLRNQGAFELPPVSVQTELMASFNMHCASWTPVVDPKWLDESAPRSMLLLQSVFLAGSRVSKAHLDYGSSEVFYRRAKLLFFFGGCDDPLISIVAACLLHWYNPVGPEDVSTDTSGFWIRTAGAMAFQIGLHKEPSPNSRDRGLRRRLWWSLVVRDNIISVGVGRPRTINLRDSDVLPPSLNDFPVNNFKSQLFLAYCTISRLLGDTVESHLRQEISRQRQVDLENAVYRWAKQVIPRLRSCVTPQDNAVTCNFEIQQVLVMYFVVLTILHRSPTPGSVPPAASLVASSFIAGIYEEFLLRDELRYLGPVFAFYPLCAGLSLLSSCRYTHLQNTAEHELTVMKLSLQKLSERWLSAVGPLRALNNLTEKVRELGPFGGVSPTLDLDAASFFEGFDTKLCKQWQIIGHSSESPSGDADISPTCTMADIQTPNDALRSLDAPPGQPVDTYDFASVDVGLDPFSNNWEGSGFDWSGSWLLNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2024-10-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>W6QC47</accession>
    <name>W6QC47_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S03</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S03g000375</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QC47"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM33651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="41" mass="4621" checksum="6A764CC2B546F1F3" modified="2014-04-16" version="1">MDSDQNEEIHSPESSLYCQVDIDRPAPLKRAMACHSRTSTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W6QCE4</accession>
    <name>W6QCE4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S02g001995</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QCE4"/>
    <dbReference type="OMA" id="YRIMILH"/>
    <dbReference type="OrthoDB" id="4450707at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="308"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="134"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="309"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="331"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="356"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM31844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="508" mass="56555" checksum="DE94354943E00319" modified="2014-04-16" version="1">MAQSPAAQDASRLSPFQVEVTEYACPDSVLEAPEETHERLRTSTPSYLTEMDESMLEDPSDTATVSQSVSTESHFISSTAPRVSYEVTASGELMITEGIQTSNPTTPARGPRPGPPPALVSFDRIAQGLPPKPASSSTTATTHPPSLSVERLIGPKQPIPARILDLFEQWHEAEPNTEHPAALTGRAPSTWKNFRAFSDDADECELSVFQILLKCQNRRILSYRIMILHSQNGPEELVVFGQPRPKFKGPWNKGVKGLYLLDWSEIEKKGEVRACGIKLWRTDDKNIAFSAYMFDDGRKCTRFLDHNAGNKQASSSTPKKQSDGNEHVEDTQSISSEPPFSPSRSGHQIPSSLSRAENETEDRTPRASRWDHPSPMWAKSISPVPTPNNYDGFRSLASPWKPQKRRRSSWSSNDQDSDPIRFKLMSDVSDQVRVFKTLDAKVLFEKAWDFYKGVDNRTGLLCTIAGLDGVRYVGDGCVDEFDILQEDIMKSSCGDEDRVVEVKPAMGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W6QD44</accession>
    <name>W6QD44_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ankyrin repeat-containing domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PROQFM164_S03g001109</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QD44"/>
    <dbReference type="STRING" id="1365484.W6QD44"/>
    <dbReference type="OMA" id="PHWHTHR"/>
    <dbReference type="OrthoDB" id="21416at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051165">
        <property type="entry name" value="Multifunctional_ANK_Repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123:SF33">
        <property type="entry name" value="PROTEIN HOS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="18"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="87"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="272"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="571"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="890"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="926"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDM34385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="1253" mass="137699" checksum="04DAA639E698C7BD" modified="2014-04-16" version="1">MDFLSSLRSSMPRLFEGSDGPPEPEDPLSPLHAAVDAEDVDQVRQLAVTADPADLTVALSRCCQSGKIASAQALLETGRCDINAAVEGDTLLFLASKKADLAIVKLLLQYGADATIRSKNGRFGDKPPAFTPLHGVADSLHPYEKLEDLPRYEELMQILLDAGCEINAQDAHGNTALLLSVHREVALILFLLQHGADPNIAEDRGGTSAHFFHHPLDHPEWFKALMANGARLDIVRSGDGYTPLHAYASKCQLGDLSLFTPFVLDWSITDDNGNTLLHIAAAKHRHGSKTIAELLNVGIDPNQRNHKGQLPIHMVEGSEQDIQDVLDILCAGGGDLEAKDYRGCTLLTKAMRGTPQWNCRELLPYFISRGANINAQDHKGNGVLSYLIEPYQFRDEYLDFLLSLGADPKMVNYEGDSFLHHLAANFATISEDTALLAMIKLMKMGVSPTLPNFRGRTPLHMLCSQSSDYLFAATAEGGKYAIDLLLDAGLGAALNLSDHQGIRPIHLATTVSEQLVGKLLARGADATVSTKDGRNLLHIASTARQSNCVGLVLDHCNSKELDSMLNTRSEDGRTPLHVACRSGRLETVNLLLAYGADVNIEDKHNRTPLDACAESIAEDQLWQGADDQQNMMNTRSAAGILVDDNHRPTQPTSNMKKTYNPKRLGWKGEITSESSTIGIGQIVRAMASHGALAHEKSFGVSPMHYAVAEGNEEMVVELDRVSREMSIEVKDFSPLQTEFYLLRSQHLPDLLGKQFREYVSETNVLPMILLGQQQEVAQAVEKSASVIEDKSAMPALMSSLARWGFSELFGRIGSTMSGNWVNGGYTNFRGQKSTPYLLAAGQRDLPNLDVIQVMVEKFNADVNIRFEAGMVDKPTVHYQSTMALDRHYKPGDTILHQLAQGIHWWHEGAIQYLLKHGADPNAQNDQGKTPLCNAVARGELGGHRQLKITRILLEGGADPNITAACGYTPLAMSAHDTELFQLLIEHGAYPSQEHPMELFVALYSFNEDAVSALLDMDLDCNTTVLSDAQPHWHTHRFQKVPATHGLILSPLLYISMVPFNEANSRDQACRMIKLLVERGADPFLPCHENQTILHEIFASGGIIQPWLDMPNLDLARRDHAGRTLLLAAASCLTGTDSYACTVSAYPFRGGRLGPAPWKEGDPTRAMALYERGADLSAIDYEGNNVLHYLADLDCSNDHFASIEVRRTLALFVEKAPQLVHRTNMHGQTPWSIAEEKNFVGFMEILQTDNVHAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W6QD54</accession>
    <name>W6QD54_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S03</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S03g001347</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QD54"/>
    <dbReference type="STRING" id="1365484.W6QD54"/>
    <dbReference type="OMA" id="PRSWSMG"/>
    <dbReference type="OrthoDB" id="3830579at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM34623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="103" mass="11560" checksum="37B79FFAD6777A32" modified="2014-04-16" version="1">MKQIDADLISFRIAMVEQLPQSMGPRSWSMGHVDRPSKLPHENSPSGQAFAYLLAVGWNSMEAHRKADKTENYARSMAPLRKKMLPPIPGLETKHVSFQKISG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W6QDJ5</accession>
    <name>W6QDJ5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g001488</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QDJ5"/>
    <dbReference type="OMA" id="DYSVWYG"/>
    <dbReference type="OrthoDB" id="4363545at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="295"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM27677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="314" mass="35191" checksum="43D66A8D4E578D1E" modified="2014-04-16" version="1">MSGSAERMEGVPGAEKSTGEAMIATEILPKERHKLLRQLRSSVRKFLDERIDKQQLKTATDKVEGQMKRYDSVPVSDLTLKEVERSLRLEYDAYDLEMKNVQPLALPPHLVTTLALIEQAFGRSRPTEARTRWFIDAVTLNAYTTATSNLTNAQPLNVQCERAYSFGPVTLNHKRVVFSGRMDYSVWYGESEGLCLNVLIVEAKGGAKSKDPIPQLLGYMGCIHRGRKNDQKRNCGVYGMAYTGSVWHFLKISHDSKWSEFAVVGRQAALEQPFGLLVWMLRKAATISPAHSKETSAETYSGVGSEEMNMDLNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W6QDK4</accession>
    <name>W6QDK4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S03</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S03g001294</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QDK4"/>
    <dbReference type="OrthoDB" id="4318382at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="85"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM34570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="101" mass="10964" checksum="BF9EDCCC975DD5E8" modified="2014-04-16" version="1">MTPSNPPQPKSPLSSEDGLQQALIKTTSFYCTALLNQVSDLLQVDYAAVAKCVGISERQAQRHFYWLKTKIASYGNATLTQAEKQGQGQNDGQDGQDGNDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W6QEL9</accession>
    <name>W6QEL9_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Altered inheritance of mitochondria protein 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S03g001642</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AIM6 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QEL9"/>
    <dbReference type="STRING" id="1365484.W6QEL9"/>
    <dbReference type="OMA" id="HWGCTGV"/>
    <dbReference type="OrthoDB" id="4153866at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08577">
        <property type="entry name" value="PI-PLCc_GDPD_SF_unchar3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039559">
        <property type="entry name" value="AIM6_PI-PLC-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051236">
        <property type="entry name" value="HAT_RTT109-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31571">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31571:SF1">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="67"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM34915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="401" mass="46063" checksum="F85E997635512639" modified="2014-04-16" version="1">MAFDPSALEPIPEHEAFILVDLEVRNTSPYMKPRRPSFSILKCSHPECIAYPRSKRAIFCRVVQRPLWALIFVFGIINLFIVAWQWVFYLFRHDTSLAIFPGERHSRFSDWSTNGVIPVPCHSHNDYWRHIPLRSALRAGCISVEADVWPWGNDILVGHSRSTVHRGTLQSLYLDPLLKILDTHNAPPSRSWPHVMNQEIVGVFPNDPKQTVTLLVDCKTDGDRTLPLLVEQLNPFREKGYLTHFNGSDIVYGPVTIVASGDVPFHLLLENTTYRDVFFDAPLGNLTFPTEITANDNKPMDSTYNPSNSYYASADFRKVIGPLSLSRLSDIQLAILRSQVFEAHKLGLKVRYWGTPTWPIGLRNHVWNVLVHEGVDVLNTDDLRGATKQDWKPHHWWQWWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W6QF25</accession>
    <name>W6QF25_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PROQFM164_S04g000234</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QF25"/>
    <dbReference type="STRING" id="1365484.W6QF25"/>
    <dbReference type="OrthoDB" id="5979581at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050684">
        <property type="term" value="P:regulation of mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051334">
        <property type="entry name" value="SRPK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634:SF9">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDM35353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="135" mass="15848" checksum="3D98C5E563DFC488" modified="2014-04-16" version="1">MLRELYDSFELRGHGGSHRCLVLQPMYMTLLEMMRLNPRPFDLPLLKMTLKRLLLALDYLHTEANVIHTDLKTDNVMLSLEETTMLADFADKEIRHPILRKSIDGTRTIYQSRQFRRPLRGKSFGLPILWSSHPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W6QFE5</accession>
    <name>W6QFE5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S01g002098</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QFE5"/>
    <dbReference type="OrthoDB" id="4328907at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM28287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="102" mass="11729" checksum="B0BE9B9098945A4B" modified="2014-04-16" version="1">MLFSCLSSTSSTRRLLRSELSHVILLLTVIVANRSLEDLDAYYRTNPSLIVTGDPDTICRKRPQKYIDREDEEFERMAVSKGVMPVETAEREHVEWIEGEGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W6QGC4</accession>
    <name>W6QGC4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein kinase-like domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S04g000346</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QGC4"/>
    <dbReference type="STRING" id="1365484.W6QGC4"/>
    <dbReference type="OMA" id="LWKACSY"/>
    <dbReference type="OrthoDB" id="428260at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF13">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="2">
        <location>
            <begin position="51"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="2">
        <location>
            <begin position="292"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM35465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="479" mass="53953" checksum="5007548261F93B16" modified="2014-04-16" version="1">MQSLESQESPFRGLEWVEETFGFEPRWTVEPEPGAIKQTVQALRPSSAVEVTFLAQGAFNKIYNVSIDNEPFIVRVSLPVDPRYKLTSEVATMDWVRHVTSLPIPRIIAYQPSRDNPIGFEWMLMTKMPGKPFGEIWKSLSFAVKACLIRELAASSACLFRNQLRGIGNIYGETSVVDNSTPSEQILPPRELINTKISVPAKGSAPNAGSSPTTKNSGALLFNPPDNGSPAGALPDVGRIVSMLFFWDSHIHQDIPRGPFRSSKDWITARLSFNENDCHSALNKHSAGDLDSDAEDEVDVAKRTLKIIDNLKSLLPLVFPTDDDDDSEPSMIFHTDLSRHNILVDDNGKMTGVLDWECVSAVPLWKACSYPSFLEERPRRLEPKTEEYAPEDTGEPSEVYFEHLWQYEATLLRDIFIDEMRKLDPGWVEVFDKSQVKRDFDYAAAYCDSWISARDIEAWIGDITTDMNNARSLGDRIWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>W6QGS0</accession>
    <name>W6QGS0_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="10">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PROQFM164_S04g000516</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QGS0"/>
    <dbReference type="STRING" id="1365484.W6QGS0"/>
    <dbReference type="OMA" id="CLIYASQ"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000078">
        <property type="entry name" value="MFS maltose transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF57">
        <property type="entry name" value="MALTOSE TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G00150)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="135"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="196"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="219"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="373"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="402"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="474"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="55"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDM35635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="527" mass="58491" checksum="8A05124834E454F4" modified="2014-04-16" version="1">MSSDKSDDLYEKAAVEQSEVLVNKDLMKDAFDGENREHEMTTWAAMKSHPWACLWAFTMCFTIVMESFDMFLNGNFVALPAFKERYGVDVEGHGYTIPTKWQSSLFQAGQCGAFVGVFLAGPITNRFGYRLTTIFALILMNATIFISFFADSLTVLVVGQALEGIPWGFFIANSPAYASEIVPLSLRGACTATLQMSWSIGSIIVAAATYGYNKRNDEWAWRVPLALQWIFPTPLLILLFFAPESPWWLIRRGRKAEALRSIERLGSESHEQAQQSLAMIERTVEIEAQMGGTPTLLDLLKGTDLRRTIITCLIYASQNFAGNLIANQATYFFEQAGMGSDRSFQLNLINSCLQLVANIISLPLASSFGRRTIYLWGTVTNMILLLLLGVCASISQNTATNYAQAVLGIIISFVFAGSLGPISYTIIAESSSVRLRALSTGVGRAAYYFAEIPMIYLASQMLNPTGWNLAGKCGYVWGGTACVCFVSAYFFLPELKGRSYRESDILFNRKIPARKFKSTVIDVRENE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>W6QHK0</accession>
    <name>W6QHK0_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Pre-mRNA-splicing ATP-dependent RNA helicase PRP28</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Pre-mRNA-splicing ATP-dependent RNA helicase prp28</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="primary">prp28</name>
        <name evidence="22" type="ORF">PROQFM164_S03g000398</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">ATP-dependent RNA helicase involved in mRNA splicing. May destabilize the U1/5'-splice site duplex to permit an effective competition for the 5'-splice site by the U6 snRNA, resulting in the switch between U1 and U6 at the 5'-splice site. May also act to unwind the U4/U6 base-pairing interaction in the U4/U6/U5 snRNP, facilitating the first covalent step of splicing.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="12">Component of the U5 snRNP complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the DEAD box helicase family. DDX23/PRP28 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QHK0"/>
    <dbReference type="STRING" id="1365484.W6QHK0"/>
    <dbReference type="OMA" id="ARDIKHM"/>
    <dbReference type="OrthoDB" id="196131at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17945">
        <property type="entry name" value="DEADc_DDX23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000322">
        <property type="entry name" value="probable ATP-dependent RNA helicase DDX23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057479">
        <property type="entry name" value="PRP28/DDX23-like_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25430">
        <property type="entry name" value="DDX23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 17 22" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="4 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="21">
        <location>
            <begin position="362"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="19">
        <location>
            <begin position="393"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="20">
        <location>
            <begin position="604"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="109"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="762"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="16">
        <location>
            <begin position="362"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="18">
        <location>
            <begin position="9"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="109"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="139"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00039685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00040398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="CDM33674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="795" mass="88262" checksum="AF70B6F720EEE34B" modified="2014-04-16" version="1">MTNGAEGFPPRPPSVERLPSPPPPPPEDLTAPPPPPDSIAPPPPPDDVPPPPPADTQKKQKLGWGAKKPAVTPLSVEDLIRKKKEADAATAKPKFLSKAQREKIALEKRAQEVEAERQAKARTNGADRNGLISAPSSVRRQEPRNVRDEPVVRHVPTGPRAMRDEHPTGPGGMRKGGRQHNQHNRDQDMPPPPSKTKGEKRLTEEDEAAALATLTKHRYMGADQTSNFSAKKKRKRTADRKFNFEWNTEEDTSGDYNPLYQRRQEANFFGRGRLAGFGDDVADEVARKYAEALVSRDHEAGSARAKQMLEMERRRREDSTRTQIDKHWSEKRLDLMRERDWRIFKEDFNIATKGGSVPNPMRSWEESPLPKRLLELIDRVGYKDPTAIQRAAIPIAMQSRDLIGVAVTGSGKTAAFLLPLLVYISALPRLDENEWRKNDGPYAIVLAPTRELAQQIEIEAKKFTQPLGFNVVSIVGGHSLEEQAFSLRDGAEIIIATPGRLVDCIERRMLVLSQCCYVIMDEADRMIDLGFEEPVNKILDALPVTNEKPDTEEAENSAAMSQHQYRQTMMYTATMPAAVERIARKYLRRPAIITIGGVGEAVDTVEQRVEMISGEDKRKKRLGEILSSGEFRPPIIVFVNIKRNCDAIAREIKQWGFSSVTLHGSKTQDQREAALASVRNGSTDVLVATDLAGRGIDVPDVSLVVNFNMATSIESYTHRVGRTGRAGKSGVAITFLGSEDSDVMYDLKQMLIKSPISRVPEELRKHEAAQSKPSRGPGGKKIEDSSGFGGKGGWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W6QI89</accession>
    <name>W6QI89_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S05g000366</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QI89"/>
    <dbReference type="STRING" id="1365484.W6QI89"/>
    <dbReference type="OMA" id="IWREFPN"/>
    <dbReference type="OrthoDB" id="4349275at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM36533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="218" mass="25063" checksum="1308D77DE087C1A2" modified="2014-04-16" version="1">MGPLDRIDYDLDLDLESIWREFPNIPTPPPCLAENRSTRCSNQPLKEWLEYTQHGHKGTPAIECVFYPSYENVRSFSWTGPDPLSQDTCADDIFLYVSAFFLFERVDWIELRLSKLSTETGEAVEEYPFFLPRVESMLGNLRRIRCQISDILSQNSTVGNITSAGQSRFQLAIRPRVEITDNSTPWSSVPLSRIHPSIPMPFLDPQTFVQNMVGNWEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W6QIP7</accession>
    <name>W6QIP7_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g003279</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0235 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QIP7"/>
    <dbReference type="STRING" id="1365484.W6QIP7"/>
    <dbReference type="OMA" id="QIACHVK"/>
    <dbReference type="OrthoDB" id="244097at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1200.10">
        <property type="entry name" value="YggU-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00634">
        <property type="entry name" value="UPF0235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003746">
        <property type="entry name" value="DUF167"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036591">
        <property type="entry name" value="YggU-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00251">
        <property type="entry name" value="DUF167 family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13420">
        <property type="entry name" value="UPF0235 PROTEIN C15ORF40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13420:SF7">
        <property type="entry name" value="UPF0235 PROTEIN C15ORF40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02594">
        <property type="entry name" value="DUF167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01152">
        <property type="entry name" value="DUF167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69786">
        <property type="entry name" value="YggU-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM29467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="126" mass="13601" checksum="A262B75CA30E37DD" modified="2014-04-16" version="1">MSSPASFLRLVPSKTPCSRKLFNLHIPCYVKPNASARRAGITNVGIDRVDIAVAAVPRDGASNMAVSRVFAEIFNVPKSNVGIIRGAKSREKTLCVADLEIGDDGEEAYLQRATQILKDAVNTRDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>W6QIS4</accession>
    <name>W6QIS4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Pep3/Vps18/deep orange</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PROQFM164_S01g003304</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Endomembrane system</location>
            <topology evidence="6">Peripheral membrane protein</topology>
            <orientation evidence="6">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS18 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QIS4"/>
    <dbReference type="STRING" id="1365484.W6QIS4"/>
    <dbReference type="OMA" id="WIQREKW"/>
    <dbReference type="OrthoDB" id="1845386at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030897">
        <property type="term" value="C:HOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048284">
        <property type="term" value="P:organelle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007033">
        <property type="term" value="P:vacuole organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006904">
        <property type="term" value="P:vesicle docking involved in exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16462">
        <property type="entry name" value="RING-H2_Pep3p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000547">
        <property type="entry name" value="Clathrin_H-chain/VPS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007810">
        <property type="entry name" value="Pep3/Vps18_beta-prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058919">
        <property type="entry name" value="Pep3/Vps18_RING_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23323">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23323:SF26">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 18 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05131">
        <property type="entry name" value="Pep3_Vps18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26148">
        <property type="entry name" value="VPS18_RING_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50236">
        <property type="entry name" value="CHCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Pep3/Vps18 beta-propeller" evidence="8">
        <location>
            <begin position="24"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="7">
        <location>
            <begin position="616"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="domain" description="Pep3/Vps18 RING C-terminal" evidence="9">
        <location>
            <begin position="854"/>
            <end position="943"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF26148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDM29492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="960" mass="107158" checksum="EDF3D2B49D462B66" modified="2014-04-16" version="1">MALDPSSSYVAPSNLMEPPSSSLPMFDVERVQLAFAVAADFVAAQVANNVLVLALSTNRILRIDLDSPEDVEDIDLPKKSSEIGVIRRMFLDPSASHLIITTTLGENYYLHAQSPSRQPKPLARLKGVSIESVAWNPSLPTASTREILIGATDGNIYETYIEPSSYRQEKYTTPVYQVPGASPVIGIAAETVSSTPDQRRVLVATYGKLLHFIGRTGVSKHGRESGVYSDLFQRETPVIHEVPNASSSAPSSLVISPTISEGYQAEGYTEKQFAWLSSEGIYHGQLTSEPPFKTARMLPRSLFPASESPRGGRKLIQDPISAMTLSQWHVLALVGGRVVAVNRLSQEVVHDQPVLEAGQSALGLLTDLTKNTYWLFTSQAIFEVVAGDEDRDVWRTFLKEQKFDEALQYARGAAQRDAVMTASGDFLASKGNFLEAAKVWGKSSKGFEEVCLTMIDHKEHDALRNYLLSQLATYKKASLMQRIMVASWLVELFMSKLNSLDDNIATKAELAEGTSTGEIKDQLGSIRTDFQEFVNSHKADLDKKTVYDIISSHGREEELLFFATATNDYNYVLSYWIQREKWLEALKVLQRQSEPDVFYKYSSVLMTHKPTDLVDILMRQTNLDPERLIPALLNYNKSAIVSSLNQNQAVRYLNFIIVNHPNPSAAVHNTLISIHASSPSPSEAGLLTYLQSQPSPHPPYDADFALRLCIQNQRIQSCIHIYSTMGQYLQAVELALEHKDIELAAIVADRPEGNDKLRKKLWLLVAEKKIRQPGTGIKEAIEFLRRCELLRIEDLIPFFPDFVVIDDFKDEICTALEDYSRHIDSLRQEMDNSALTARQIRGEISGLDTRYAIVEPGEKCWICSLPVLSRQFFVFPCQHSFHSDCLGREVLDGAGGKKKYIRDLQAQLSSGDISSSRREEIVKELDGLVAEACILCGDHAIKQIDKPFIGKSETAEDWAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W6QJ07</accession>
    <name>W6QJ07_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aldolase-type TIM barrel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S04g000882</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM36001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QJ07"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:flavin oxidoreductase/NADH oxidase N-terminal" evidence="1">
        <location>
            <begin position="6"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM36001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="56" mass="6523" checksum="88056D1AA8F023FD" modified="2014-04-16" version="1">MAVKADFAIKIRSAHAYLFHWFLSLVETKRADQYVGSFENGIRLFIDAVQAESWFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W6QJ12</accession>
    <name>W6QJ12_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Ankyrin repeat-containing domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PROQFM164_S04g000887</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">The VLRF1 domain mediates binding to the 60S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the ANKZF1/VMS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM36006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QJ12"/>
    <dbReference type="STRING" id="1365484.W6QJ12"/>
    <dbReference type="OMA" id="GPHIFMC"/>
    <dbReference type="OrthoDB" id="429841at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047139">
        <property type="entry name" value="ANKZ1/VMS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041175">
        <property type="entry name" value="VLRF1/Vms1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16036">
        <property type="entry name" value="ANKYRIN REPEAT AND ZINC FINGER DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16036:SF2">
        <property type="entry name" value="TRNA ENDONUCLEASE ANKZF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18826">
        <property type="entry name" value="bVLRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52044">
        <property type="entry name" value="VLRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 10" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 10" id="KW-0540">Nuclease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="VLRF1" evidence="12">
        <location>
            <begin position="226"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="274"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="397"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="547"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="281"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="398"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="550"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="605"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDM36006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="644" mass="71456" checksum="63C7C65560B27363" modified="2014-04-16" version="1">MVDTTQMEELLKRPLYVYDLPPELLASLTAKTSQPVAEQEPEPSPIDLELAAQDSAIATSNLCSLCRVSYNSVQEQRSHVRSDHHRYNIKAQLRGNAPLEEIEFAKAIGELDESISGSESSETEEDDAEGAAGTTLSALLKKQAKLSHPNEDPEATETPIAPKHPIFWLSSSGLPSNKSLGVYRAIFSNAEQDEPAHLVDTLRRKQLAPVKARTNKASNVQDPAASGPHIFMCMIGGGHFAAMLVSLAPEIHRKQGGVEDRQARVIAHKTFHRYTTRRKQGGSQSASDASGRAAHSAGSSLRRYNEAALEKDIRDVLSEWKDMIDTAELLFVRATGKTNRKTLFGQYDGQVLRQNDPRLRGFPFNTRRATQGELMRSFKELTRMKVSEVDEAALAAAEAKRREQESKSSTHVQKPQPQKPKLSKEEEAALLHTSQLQALIRRSKVPALMSYISNNSIPSSFTFTPADSPQNFRCPTLLHLAANLDAPAVVTALLTKAGSDPTAVNNEGRTPFELTGDRATRDAFRIARHDLGESKWDWEVAKVPSAVSKADAESRAEKERKIAEEEESTRRKASLDRLQREEAEKAAKPRTTKSGGRTVGAVEKSAAERRDEETRGMTPEMRMRLERERRARAAEERFKRMQGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>W6QJB8</accession>
    <name>W6QJB8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="10">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PROQFM164_S03g001008</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QJB8"/>
    <dbReference type="OMA" id="AISMIYV"/>
    <dbReference type="OrthoDB" id="5296287at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000313">
        <property type="entry name" value="MFS quinate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF8">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="136"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="161"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="293"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="335"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="362"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="404"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="475"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="31"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDM34284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="558" mass="61075" checksum="B9B1A61168B83E9A" modified="2014-04-16" version="1">MAGGAKKPVNIFRLKDLGEPKEVFNWRLWFSVISFGLMGAARGVDEGLISGAFNSKDFQRYINYDSYSQVEQTNIKGNVTAMVQIGSVGGALFAFLVCDRIGRIWATRQLCVLWIVGIAVFMGNGGSLGAVYAGRFIAGLGVGQTVVVAPVYLAEIAPASIRGLCTCVFTGFVYLGIVLAYFANYGCQINLGDNTHNRWLVPTSLHIIFAGLIFLLSFLQHESPRYLVKRGQLEKAISNLSKIRGLPSDDEYVVREISSIQTTHAAEMEATMGSGAMGVIKETFLVPSNLYRVYLTFMAQLLSQWSGAGSITVYAPDLFKLLGVTGNNESLLVTAVFGIIKLVAAILCALFLVDVIGRKRALLLGITLQAIAMIYIAGFLTSVPEMGVDESYKVPADKKSASEGAIAMIYLSGFGWALGWNSMQYLLTAELFPLRIRALCTSMAMTLHFANQYGNARAVPNMLLPVAEGGIDPKGTFWCFAAITVIGGVWVWFSIPETAGRSLESMDRLFALPWYKIGRYGNRDADERDLVVDEKMEMAVQTHGTAQHVERQDRENRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W6QJH8</accession>
    <name>W6QJH8_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PROQFM164_S04g001047</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM36166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QJH8"/>
    <dbReference type="STRING" id="1365484.W6QJH8"/>
    <dbReference type="ESTHER" id="penro-w6qjh8">
        <property type="family name" value="Fungal_carboxylesterase_lipase"/>
    </dbReference>
    <dbReference type="OMA" id="TMWAGFI"/>
    <dbReference type="OrthoDB" id="4526243at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="5">
        <location>
            <begin position="63"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDM36166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="591" mass="65393" checksum="C2D3E08398985CC9" modified="2014-04-16" version="1">MIEYGPLESERSAMQAPERRKNHICQQRISISVSLLFLVVLASALWFVPEFFDTHRENPHHEPLAKTRNGTFAGTHNFRFDQDIFLGMPYAQAPIGDLRFHYPRSINVSWNHIQPALEYGPHCIGYGDHQEQFKKSEDCLTLNVVRPSSYKQGLLPVGVFIYGGGRHGGGSGDGRYNLSYLISHAAEENLSFIGVSFNYRSSIWGFISGDQIKGTRNTNLGLHDQRLALHWVQENIEAFGGDKSRVTIWGGSSGADSVGLHLTAYGGRDDGLFRAAIMQSGGPIVKTSYSSFTPEEMYQRLSVASNCKDVENSLECLRHIPLNDIDAAFNDSAQANSQMMASFAIPTLDGNFVEGYGSLAITERRYVPVPILSGIVSSEAATWIPPQISTWKDLAIFLTEDSGYPSSVSERLLSYYPESGVAETLEPPIGSISDKDTFERVKTVIGDIEMNAAQRLVCESFSTSATCFNFIFNATPAWQRDSRVGVPHGAEIAPIFQNLDGLGFDGNSFHGKGPGYYEMSSLMGTMWAGFITTLDPNAGLKQGVYNWPKYESVNRDTLVFDEVNVGLTIQDTYRADALRYISENFAGVFDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W6QJL0</accession>
    <name>W6QJL0_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chitin synthesis regulation, Congo red resistance, RCR protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S05g000034</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QJL0"/>
    <dbReference type="OMA" id="YDWGRWV"/>
    <dbReference type="OrthoDB" id="3556830at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020999">
        <property type="entry name" value="Chitin_synth_reg_RCR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28187">
        <property type="entry name" value="PROTEIN RCR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28187:SF1">
        <property type="entry name" value="PROTEIN RCR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12273">
        <property type="entry name" value="RCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="79"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM36201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="151" mass="16806" checksum="AE2674148F44FA06" modified="2014-04-16" version="1">MPALYPRYCSGYFGDNDCYSTWDSWGRWVAFAVIVGVAFLIFFGFACFNARRRRNHGQRPLTGTGWMAPPPGPPPPNQPIYQQPPYGDPYYQQNAPPQYTPNPQNYGYFGAQNAPPQQQGIELQQPPNAYTANSPHGYAPPPGPPPNGNKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W6QJX2</accession>
    <name>W6QJX2_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S02g000016</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM29867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QJX2"/>
    <dbReference type="STRING" id="1365484.W6QJX2"/>
    <dbReference type="OMA" id="LAICYCA"/>
    <dbReference type="OrthoDB" id="4232626at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM29867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="143" mass="16824" checksum="62EFF0F48AD023F7" modified="2014-04-16" version="1">MTQSPYHDDFIPHPEDPVTWENNSQYAPIPGYCGSPNATRFNYSPSPSVLSEWEEGRVYDKDPPTYIHYRIEWRVTVNNREVSMDTEEDLVLAPSAFWQLFLEKKLEKVLRRKIARHRPVRADDTAIVVLVTDRTQRNSTKRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W6QK99</accession>
    <name>W6QK99_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Caffeine-induced death protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S05g000663</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MIX23 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QK99"/>
    <dbReference type="STRING" id="1365484.W6QK99"/>
    <dbReference type="OMA" id="QFCFNER"/>
    <dbReference type="OrthoDB" id="5593818at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019171">
        <property type="entry name" value="MIX23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016805">
        <property type="entry name" value="MIX23_fungal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31905">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31905:SF2">
        <property type="entry name" value="PROTEIN MIX23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09774">
        <property type="entry name" value="MIX23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF022603">
        <property type="entry name" value="UCP022603"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00024204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM36830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="192" mass="21819" checksum="36B7F451981632B9" modified="2014-04-16" version="1">MSQPSSTAPPALTPRFCFDERLLRDFLRLSRSTIDDSITQNLNALITPAQRGFDPASTAVRQPESGSRINSAACQNFKDNVLFPSWQTRSDVLTYCAGVATSPDPDDPDLILRQTESARDREREVDERLDPYSARFFPREPRTESLANLIRNERTVEEIVRARTWGMVSEKCSGSSSTWEEALNTWRHSHQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W6QKL6</accession>
    <name>W6QKL6_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Velvet factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PROQFM164_S05g000374</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QKL6"/>
    <dbReference type="STRING" id="1365484.W6QKL6"/>
    <dbReference type="OMA" id="AMSHGSE"/>
    <dbReference type="OrthoDB" id="3056235at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3960">
        <property type="entry name" value="Velvet domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021740">
        <property type="entry name" value="Velvet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037525">
        <property type="entry name" value="Velvet_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038491">
        <property type="entry name" value="Velvet_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33572:SF17">
        <property type="entry name" value="SEXUAL DEVELOPMENT REGULATOR VELC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33572">
        <property type="entry name" value="SPORE DEVELOPMENT REGULATOR VOSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11754">
        <property type="entry name" value="Velvet"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51821">
        <property type="entry name" value="VELVET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0749">Sporulation</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Velvet" evidence="7">
        <location>
            <begin position="195"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="269"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="313"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="270"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="316"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM36541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="436" mass="49616" checksum="598F95323414F008" modified="2014-04-16" version="1">MYPRHEPRHFLSPHILYDRPILAGPPGPRSPSIGHLPERSDARHMALQENAYMNHPHMPRELPLQMHHCERCGCFSAPYEEKLNPAMSHGSEYSPRVQTHDLKSRQPYPYMPADFKRFFHVENYTAIAAAQQLYWARLTQKSQCAFIEAQSPALALASAQATRPRNTKYSMPHGFEQLLHHEPESSSPPPPRRKPTLSRYHLHVRQQPLASRACGASDWNRRPVDPPPIVQILLSDFGHQSKDDRDILQDPRFTVGCLLFLVSDSFNELHSQDKQGPEREKERDSVTRADEVLPTPLLGKVFMSPFYVDVDPDPISAPTHPSSHTQSPSLALDPDNNHQASKLHQPATFFIFTDLSIRSAGTYRLQFRLMNWGSVEDTGQSMPILAEAWSDLFRVYPAKDFPGMRDSSVLAERLKELGFAELNIRGKGKGKGRKKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W6QL53</accession>
    <name>W6QL53_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AMP-dependent synthetase/ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PROQFM164_S06g000146</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792020">
        <property type="protein sequence ID" value="CDM37185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QL53"/>
    <dbReference type="STRING" id="1365484.W6QL53"/>
    <dbReference type="OMA" id="HILVVIM"/>
    <dbReference type="OrthoDB" id="416786at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043041">
        <property type="term" value="P:amino acid activation for nonribosomal peptide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527:SF1">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="4">
        <location>
            <begin position="138"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDM37185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="431" mass="47759" checksum="666E1B81B5A32EA3" modified="2014-04-16" version="1">MAIRLEDGTIEIVGRIDFQTKINGQRVEPGEISALLRQQSSVRAAVVVAATVEQEKALVACISPSDTSLSWPRVVSSLRTATLASLPSYMTPAYWMPFDDLPVNSNGKTDVLQLRNRIQAMKRSDLIGASMDTEEVQRELSNMEKVLQLAWAKVLSLPSEVITINQSFLALGGDSLKALLVISELLSHNYLAELGDMLRADSLATAASSLTYQENASANQDSPTPFSLIPGETDVDRTTFEDAYPATPSQEGIISAHNSAGGYVYHRVFDIEGYDVSRLQQALQMVINNNAIYRTGFVAHGTGFLQMVHRQFELPWDIVNDTASIDSYVSQVRKQEMDIAQPLVRAAILNGHILVVIMHHVLFDFWSSKVLVQDAAAIYNNQTVASRLSFNIFVRHYQQQVDEKAASDFWSDYLQNTSATRLTLLEGLLML</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W6QMP9</accession>
    <name>W6QMP9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S06g000192</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792020">
        <property type="protein sequence ID" value="CDM37231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QMP9"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM37231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="34" mass="3799" checksum="138D54E04732DF48" modified="2014-04-16" version="1">MSLFFASQTRINGHNTYPRKGDPSSPLYIQCGIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W6QMX9</accession>
    <name>W6QMX9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein kinase-like domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S10g000052</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792024">
        <property type="protein sequence ID" value="CDM38238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QMX9"/>
    <dbReference type="OMA" id="HYLFYSQ"/>
    <dbReference type="OrthoDB" id="4177236at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF48">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="58"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM38238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="296" mass="34001" checksum="ED49860BD8DC45B1" modified="2014-04-16" version="1">MWEPVAIPFQNSKPLPTLPTTDEIRACTNVLWETMASKIVAVNDDIVAKYGGTVNAWEGQALVYLERYVPGVPAPRLYAMYYESKQVFMIMQRVPGVPLNSIWPSLVDSEKDDIIAKLKLISDTMRKAECPWPDFFGGLDGGGVHHYLFYSQHGDKKFLGPFSGEPAFVAALVGNYRALVERNKRPDFKARFYEKHWARVLQGHRPTLTHGDLQQKNIIVAENTSRPNDQGGRSFDVVLVDWENSGWFPDFWEFFCASSPFIFDWGEDWSWRVQEFLQVWPAEVAMMQLIDRDLGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2024-10-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>W6QP15</accession>
    <name>W6QP15_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S04</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S04g000705</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QP15"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM35824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="36" mass="3964" checksum="F888F44D7A6003AD" modified="2014-04-16" version="1">MPALRRYPILKMRTSYSATATARGIIGQATLTPEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2024-10-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>W6QP31</accession>
    <name>W6QP31_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S02g001492</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QP31"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM31342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="49" mass="5626" checksum="439325B4C48DCBA6" modified="2014-04-16" version="1">MPGILYINDSGIPPRSMEEYNHWCECLSRVHLAESLSDLGSDVYFVHIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W6QPP9</accession>
    <name>W6QPP9_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Copper homeostasis protein cutC homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S08g000022</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CutC family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792022">
        <property type="protein sequence ID" value="CDM37971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QPP9"/>
    <dbReference type="STRING" id="1365484.W6QPP9"/>
    <dbReference type="OMA" id="HRAFDQC"/>
    <dbReference type="OrthoDB" id="7392499at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.380">
        <property type="entry name" value="Copper homeostasis (CutC) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005627">
        <property type="entry name" value="CutC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036822">
        <property type="entry name" value="CutC-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12598">
        <property type="entry name" value="COPPER HOMEOSTASIS PROTEIN CUTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12598:SF0">
        <property type="entry name" value="COPPER HOMEOSTASIS PROTEIN CUTC HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03932">
        <property type="entry name" value="CutC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110395">
        <property type="entry name" value="CutC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM37971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="264" mass="28916" checksum="32FC36DBBA84B32B" modified="2014-04-16" version="1">MSQANITQRPILEIACFNQESAAVAARAGADRIELCKDYHLGGLSPDTDTLELLKSQLAIPIYTMVRPHAEGFCYDEFDFEVMKRTLNSLKSYGADGFVFGILNRSPQKPFDPKMSWIDVSRNRQLVELADGRPCTFHRAFDLIPESHWESALADIMECGFASILTNGGASGTKATDCVDKLQALVRYQTQPQGKIKLRSNIVPEIIVGGGVRASNIGLLHSVTGASVFHSAALLGSEEVTCANEVFKMKDKISRVSEADEMAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W6QPW0</accession>
    <name>W6QPW0_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S12g000074</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792026">
        <property type="protein sequence ID" value="CDM38465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QPW0"/>
    <dbReference type="STRING" id="1365484.W6QPW0"/>
    <dbReference type="OrthoDB" id="4369213at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM38465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="111" mass="12161" checksum="34F92F12CC2F9809" modified="2014-04-16" version="1">MQSAVLLEKEVSDLRAENEKKKQKRTRSKRQIPAAEGLSVQEASEMIAGLVEASEIPLDPPSGSTQSSGKLPILLCFMVGPACISLLLISVSQLTQSEEIVRDEETARDHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W6QPX8</accession>
    <name>W6QPX8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycoside hydrolase/deacetylase, beta/alpha-barrel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S04g001020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM36139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QPX8"/>
    <dbReference type="STRING" id="1365484.W6QPX8"/>
    <dbReference type="OMA" id="WESSQEG"/>
    <dbReference type="OrthoDB" id="3162524at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10938">
        <property type="entry name" value="CE4_HpPgdA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037950">
        <property type="entry name" value="PgdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47561">
        <property type="entry name" value="POLYSACCHARIDE DEACETYLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G05030)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47561:SF1">
        <property type="entry name" value="POLYSACCHARIDE DEACETYLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G05030)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NodB homology" evidence="1">
        <location>
            <begin position="27"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM36139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="314" mass="35922" checksum="4357105E46381129" modified="2014-04-16" version="1">MGKKRVLVGYGVDIDAVAGWLGSYGGEDSVSDISRGLWAGHIGTPRVLKLFEKYNIKATWFIPGHTLDTFPEECAMVRDAGHEIGLHGYSHENPCDLSTEQQRDILDKTYKMLTEFCGKPPRGIVAPWWEASAEMVELLLAYGIEYDHSMSHEDCQMYWLRTGDTWTKIDYKQKAETWMKPLVRGNTTGLVEIPGSWYIDDLPPMMFIKNSANSHGWVNPRDVEDIWRDHFDYFYREYDEFVFPMTIHPDVSGRPHVLLMHERLIEYINSHEGVEWVTFEQMCDEFKGKSQPPLGALMPAAPGAIAKAQAQDQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W6QQT4</accession>
    <name>W6QQT4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S11g000019</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792025">
        <property type="protein sequence ID" value="CDM38316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QQT4"/>
    <dbReference type="OrthoDB" id="4499469at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM38316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="56" mass="6245" checksum="6765079E04654468" modified="2014-04-16" version="1">MPSQSLTADEAVAKLLKFSKLTHHRTYLKDSEQKRVDDAFQLLTNGRPSTDAKGAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W6QRJ7</accession>
    <name>W6QRJ7_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alkaline-phosphatase-like, core domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S05g000517</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QRJ7"/>
    <dbReference type="STRING" id="1365484.W6QRJ7"/>
    <dbReference type="OMA" id="TEARPYI"/>
    <dbReference type="OrthoDB" id="96314at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052701">
        <property type="entry name" value="GAG_Ulvan_Degrading_Sulfatases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43751">
        <property type="entry name" value="SULFATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43751:SF3">
        <property type="entry name" value="SULFATASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="37"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="119"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase N-terminal" evidence="3">
        <location>
            <begin position="508"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="292"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM36684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="846" mass="95206" checksum="43E8B0F949F79D1B" modified="2014-04-16" version="1">MIVTRFHHPQRLILSILVLSGLCSKLLHIYQHRSLPLYLLAIYFPTFFIQEVLLFVTVWILLYTTSGRWAVAAVIGSAIIACTDLLATASQFSFYSQTGSEIQWDAARSVGASRQGQKLILSGLVPMAATTTVIVVASWLMAQGIWNLMTRWLCSLAHLGDAKTSAVLPGPSDLRNILVSNRPRLWTLVGTGVTIGLWLIRPAIPYNHMTGALPFTMLGEHSRARQMTIETFPLPELLAERYREPENGHYKGWAPTLDDSSNTAYGKNKPAWAQGPLPAAFERWIVNPDSNTADSTIQSLSRRGGNKSHSEGQNKTAGPRHYFYNPVQDPLRINNIDLEPLGPLQEALKDHAIPINHIVFVFLESGRKDLFPLKNDSRLYNQIRESYEIYGEEDEADLHDKLSQLTPVAEMLTGEPSGFGASVSSPNPGLGGLSFDGIVSGSSLSAKSRLVNYCGLGPLPVDFMHENDIIPYQPCLMHIMDLFNQRKNSSSSRNSTDSHLEREWETIYAQSVTGEFQEQTRLMDLLGFNKTLYSEDIDVEDAKYFHEDMEKINYFGYAETEARPYIKDLIDETLRQNKRLFLSHFTSTTHHPWGTPEGWNREHYFGDLHKSQHELMDDFLNANHFVDTWLGDLMGLLGEAGIANETLTVFVGDHGQAFGEDCPITGTYHNPHISNFRVPLVFHHPLLPRMHLNVNGSAVSILPTILDLLVNTNSLNADDTEIALDLMNEYEGQSLIRPYRTSHNGREAWNMGVINAGGSMLSVASAAVPWRLNLPLNNDFEYRFTNLNTDPYELEPITGWTMDSLAAEVHSKYGQEAFEWVQKAEKVGIWWVAERKKLWNYSDPDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W6QSG7</accession>
    <name>W6QSG7_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PROQFM164_S06g000019</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="HG792020">
        <property type="protein sequence ID" value="CDM37059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QSG7"/>
    <dbReference type="STRING" id="1365484.W6QSG7"/>
    <dbReference type="OMA" id="YHSMTIG"/>
    <dbReference type="OrthoDB" id="4367430at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050684">
        <property type="term" value="P:regulation of mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051334">
        <property type="entry name" value="SRPK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634:SF9">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM37059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="104" mass="12024" checksum="81DE1CBD29DDBFD3" modified="2014-04-16" version="1">MRNLLSCPFRPFRTRLLLSIPSKARQTQHYQNQIRGFLCTAALMSHSPKDDSSQHLYEPIEGVEKLESYRVGGYHSMTIGDHIHNRYQVVHKLGHGTYSTIWLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W6QSH4</accession>
    <name>W6QSH4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PROQFM164_S06g000024</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792020">
        <property type="protein sequence ID" value="CDM37064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QSH4"/>
    <dbReference type="STRING" id="1365484.W6QSH4"/>
    <dbReference type="OrthoDB" id="1844152at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206:SF2">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE AUSG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM37064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="145" mass="17392" checksum="6BC188C0EBC18140" modified="2014-04-16" version="1">MEGQRLVTDPRRILINVTKTKLNNQSSQCGLLHEHLTEALDKTWMDHDDWHTTDWSQHAVGFIGQILNYHFDMNTFMGIRSLRAWPAFLRPFVHWFLPELRKCRQQMRLARLMLQPILDRRAHEQSRSIEPGEIEKFEDTIQWLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W6QSX5</accession>
    <name>W6QSX5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S02g002758</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QSX5"/>
    <dbReference type="OrthoDB" id="10409379at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM32607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="54" mass="5967" checksum="8CAAA49D8C5446A5" modified="2014-04-16" version="1">MPEVILGGTLICQEARQNISIPAPFSTSGKTSNVIRRQRGSRIRYQQPTPLEGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W6QTH9</accession>
    <name>W6QTH9_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">MOZ protein represents a chromatin-associated acetyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PROQFM164_S06g000416</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792020">
        <property type="protein sequence ID" value="CDM37454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QTH9"/>
    <dbReference type="STRING" id="1365484.W6QTH9"/>
    <dbReference type="OMA" id="TSAFMII"/>
    <dbReference type="OrthoDB" id="5424147at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024461">
        <property type="entry name" value="CCDC90-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14360:SF12">
        <property type="entry name" value="MOZ PROTEIN REPRESENTS A CHROMATIN-ASSOCIATED ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14360">
        <property type="entry name" value="PROTEIN FMP32, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07798">
        <property type="entry name" value="CCDC90-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="397"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="41"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="42"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="140"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="172"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="213"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDM37454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="466" mass="51518" checksum="5C9463E9D3145391" modified="2014-04-16" version="1">MLVTTMATPRLPFLYPNFMRAVRSCEPRTYRSIRIPYRLNQRFHTSQQQERASYQRRYGPAVEPNTAHSLRPKKGPHDQEVPGDPSAGHDGVNASDQGQAPPDESQSEPPPQEAEQNNADVTSSETPTADQRNADQPTEAETKEDKEDKEDNPPTDREPHEEQAKDIDGAEQEQASASSSPASEAPSEESTDTSSSTNQTPFEDVLHMPSPSVFLTPTGEPSSSDDRPPHLSAAPYVHPFDTYSLVQDLSKGGYSEEQSTTIMKAVRAILQNNLSLARASLTSKSDVENEEYLFKAACSELQSSLQTARNSEIQHQRSSRTQLQHETDIISQRLSQELSGMKDDIKGMFNDHKMSTREPQRTIDTSVQELNYKITVSLNSDGKSEIEGLRWILTRRAASTIAICAFMIIVFLKYASVHKVPEPKQAKQAEKPAASKEIATEVRAVQDGGIQTVFPSAEAHLGESLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W6QTP4</accession>
    <name>W6QTP4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S02g003063</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QTP4"/>
    <dbReference type="STRING" id="1365484.W6QTP4"/>
    <dbReference type="OMA" id="PTEYSKD"/>
    <dbReference type="OrthoDB" id="429427at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071008">
        <property type="term" value="C:U2-type post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000390">
        <property type="term" value="P:spliceosomal complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012890">
        <property type="entry name" value="GCFC2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028211">
        <property type="entry name" value="Ntr2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12214">
        <property type="entry name" value="GC-RICH SEQUENCE DNA-BINDING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12214:SF0">
        <property type="entry name" value="LD29489P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15458">
        <property type="entry name" value="NTR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="229"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="357"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="97"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="229"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="249"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="394"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM32912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="409" mass="45328" checksum="305A562CB1B591B5" modified="2014-04-16" version="1">MSSKFANRRKPRKVGRDDEEDEGGVAPEPVVKRPASSRLKLRSKLQLSFGPETSNDGDQDSEVVPPKRHGLGRKAIEQSAGQLPSLLSEKITARVGQDQDRPTYSHDYLKELRDSTPSTPKTTTDDETSKVVDVAAKFGEIMTLPAQAHIPSEAEIREKKARRARLAMEHGAEDEFISLDVNNAAHTDDWDAVVRGDKEVEQDTRLVRDDEDFAEGFEAFTEDGKMALGRKAEREKKRKDREAMRDLIEDAEGISDEDDSDLEEKAAYEAAQVHSAMGRGKSSGIDRPRTPPKVTSLPRLASSFERLRMSLTSMEVAKTQMISRMEELRKEKADIAVREVEIQAMIKEAGDNYERLRKEAGVDPNTKLDGSNGALEKSRGLESIGAPVPVPVRDSSMSDSSDSSFEDSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W6QTV0</accession>
    <name>W6QTV0_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PROQFM164_S06g000536</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
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            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="HG792020">
        <property type="protein sequence ID" value="CDM37574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:protein serine/threonine kinase activity"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:regulation of mRNA processing"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
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        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051334">
        <property type="entry name" value="SRPK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634:SF9">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
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    </dbReference>
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        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Protein kinase-like (PK-like)"/>
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    </dbReference>
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        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="5 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="39"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDM37574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="413" mass="46579" checksum="520C18812DCBC835" modified="2014-04-16" version="1">MASRIYAPSPSTFAEDPDRYRENGLHPLTIGDILKFGRYRIVHKLGSGSFATVWLGRDTSENKYVSLKILSADTPLDCKELRILQEITESELNHKGREFVVQLLDHFTIEGPNGRHLCVVTPVAGDRLARKPGLPYNSLEWPRIIGLQIAEALGYLHVLGIAHGDCYTSNILSQVLPFDDWTEEELYACLGQPVKHQVRRLDGMPREDNAPEYTVDPCDITALEARLSTDRILLIDFGAAFYHHESPEQIFTPAPFASPEILFGGELTFAVDNWAFGCLLYELCADRSLIKLLFGWNNDAMKDQVAMLGKPPDALWQNWEGKDKYFHPDGTPKEAHDRRLKVYPLSLKQRVRNLEKPLSERGYGTGDEAPLPPDLQNLFDLLNGVITYDARSRMSFEGVQAHPFFRGVNIPGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W6QU63</accession>
    <name>W6QU63_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sas10/Utp3/C1D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S07g000022</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792021">
        <property type="protein sequence ID" value="CDM37674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QU63"/>
    <dbReference type="STRING" id="1365484.W6QU63"/>
    <dbReference type="OMA" id="RHTKSER"/>
    <dbReference type="OrthoDB" id="203440at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007146">
        <property type="entry name" value="Sas10/Utp3/C1D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13237:SF9">
        <property type="entry name" value="NEUROGUIDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13237">
        <property type="entry name" value="SOMETHING ABOUT SILENCING PROTEIN 10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04000">
        <property type="entry name" value="Sas10_Utp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="298"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="298"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM37674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="379" mass="42391" checksum="F942FCE0A26FE567" modified="2014-04-16" version="1">MAPTQASARPQSLPTLLETLNNCLSTTASSLPKPHKDAPSDVTIEPPKDGISLLDTKSEILLSYLQNLVFLIIFQLRNVSAKETPKEKSQSTDNSLEDDIRKKLIELRVFLERGVRPLEGRLKYQIDKVIKAAEDAERTEKAQPTKTKKSRKAATSGSEASSDEDEDVNGSENEEDIDEMAYRPNVSAFSKGVAEQKKARPSKGAVESPGDGIYRPPRIMPTSLPTTERRERQDRRPIRSNVIDEFVSAEMSSAPMAEPSIGSTIIDGGRTVKSKKDREREAERTTYEETNFVRLPKETKKELAKRGRGKDTTYGGDEWKGLNEGADNIERLTRRSKSNGAALEKSRKRVRNEDGQRGDGVGMGQVFDKRRKKVDSWKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W6QUN3</accession>
    <name>W6QUN3_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AMP-dependent synthetase/ligase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S07g000172</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792021">
        <property type="protein sequence ID" value="CDM37824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QUN3"/>
    <dbReference type="STRING" id="1365484.W6QUN3"/>
    <dbReference type="OMA" id="CGILQWQ"/>
    <dbReference type="OrthoDB" id="10047078at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43845">
        <property type="entry name" value="BLR5969 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43845:SF1">
        <property type="entry name" value="BLR5969 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM37824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="463" mass="51533" checksum="47C99D6D8E8CABDF" modified="2014-04-16" version="1">MATERYSLAEVLAVAKTHPFYNPDTVYPADAETIRNLRKTVTDQEAKAKFQEQPLLEKKTLYKAIERLSHDVDPRNTYRQSSYVSITGGGSGGVPMMFAVDVHENRRQRAQFGEFLKLCGVIQPGDWVLSTHVAGGFYRSLDLTTEITENAGATVLSAGSYMSPTDVAKSLADYHVNILTGDGSQVVQVVYHISLMAPEDRNRIALDKIIYTSEPLTGPQRAFIKAVLGDVKIISLMGSAEAGPWAISSPDLTGEQSLTNNSTDFVFDTRNILIEIVSPSAVDGVSSPDPILLPEGEQGLIVQTSLQRLRNPLVRYITGDIGTLHPLPSAACAVIPEADRDYIRVLRMRGRDNRFSFNWFSSYFEFEKIDALMRADDCGILQWQLIMDRLESTPQATLEIRLLRSPPRDGILSDDALINRFKAFFVIGSDNEELFRIVFLDNLGGFERSATAAKIIKFVNRWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W6QV92</accession>
    <name>W6QV92_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DNA repair and recombination protein RAD54B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">RAD54B</name>
        <name evidence="7" type="ORF">PROQFM164_S08g000105</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792022">
        <property type="protein sequence ID" value="CDM38054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QV92"/>
    <dbReference type="STRING" id="1365484.W6QV92"/>
    <dbReference type="OMA" id="KCQTHEL"/>
    <dbReference type="OrthoDB" id="413460at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015616">
        <property type="term" value="F:DNA translocase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18004">
        <property type="entry name" value="DEXHc_RAD54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000035">
        <property type="entry name" value="DsDNA-dependent ATPase (Rad54b)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.850">
        <property type="entry name" value="SWI2/SNF2 ATPases, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050496">
        <property type="entry name" value="SNF2_RAD54_helicase_repair"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629:SF7">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629">
        <property type="entry name" value="SNF2/RAD54 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="298"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="621"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="163"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="815"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="11"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="24"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="70"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="176"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="833"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="868"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="885"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="895"/>
            <end position="911"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM38054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="975" mass="107573" checksum="949E8E126DADE3D2" modified="2014-04-16" version="1">MVFKPFKSPLVRNSATTSTNNPDEPSRPTKKPRLEDEPAPKDVQSPIDSRKPLLQVNKRRSDSTTQSSSGEKDDTSDERYFNVLWRKPSAKKHKTWDGDGILSTRGEFVYLRDIAGKEMGRKVHEARLEPGTTLSISGKEIEIDSEISRKEYLSGRVFLEATKSAPTSTPDPVPTPKKEALPARKKGEVRKPTAAERTQSLKRSLALVTNPNANPGTAPAKFAAYKAPLLVNTVAPKVMGKVVPRHDPKAVGALVMPRPKSVPKGKQVVDVVVDPLLTKNLRPHQREGVKFLYECVMGMRSFNGEGAILADDMGLGKTLQTIALLWTLLKQNPVFEAPPVIKKALIVCPVTLINNWRKEFRKWLGNERIGVFVFDDKSKRLTDFTKGRAYSIMIVGYEKLRTVQEALANGSGVDIIIADEGHRLKTLQNKSGLAIQSLSAVKRVILSGTPIQNDLREFFAAVDLVNPGILGTFKSFIREFETPIVRSRQPEATRKEIEKGESRGEELRELTSKFMLRRTADILAKYLPPKTEYVLFCKPTRPQANIYKAVLASPIFQTAMGNAESALQLITILKKLSNSPSLLTAKNNNNTPNETMTALIASIPQPLHRHLSPSSSAKIRVLDQLLDTMRNKTDEKIVLVSNYTSTLSLLATLLTSLGLPYLRLDGSTPAQKRQGLVDDFNRLPASSCFAFLLSAKAGGTGLNLIGASRLILFDVDWNPATDIQAMARIHRDGQKRPCRIYRVLLKGSLEEKIWQRQVTKLGLADSVMQERSTSNSGAQFSAAELRDLFRLDEDRACQTHELLGCRCGGRGVPADVEASSSGAATPATVDAGSEGEDLSDPPSDFDDFDDGYDSDESLPKPHTLVKASEVDMEKQEQSIRDGTHRAKIARKGKKSTKDKESETKSPKDKMHQSLAQYSHIDPSLLAAESDSNEAGAEDEELEAAIDDDVLVSMLKDECNLIGYVFKKTNGAEMRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W6QYD3</accession>
    <name>W6QYD3_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Zn(2)-C6 fungal-type DNA-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PROQFM164_S03g001286</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QYD3"/>
    <dbReference type="OMA" id="EWMRTII"/>
    <dbReference type="OrthoDB" id="434972at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050797">
        <property type="entry name" value="Carb_Metab_Trans_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668:SF18">
        <property type="entry name" value="MALTOSE FERMENTATION REGULATORY PROTEIN MAL13-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="6"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM34562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="415" mass="46455" checksum="D6395AA97EBB62D0" modified="2014-04-16" version="1">MPPKRACDICISRKVKCSGSWPCDTCRGAAKRVRCTYLRPAHRRGPKSRRVCHRETDLPEIQSTEIQQNVEEDTYIQNGSNDTISSSATACSLHCIPKTVFASVIRLYQQYSYSVWPVVNAEALLRRVEDIYLEKVDSNAGNTSCLIMALCAATMAQLHLDPSVYGSQKVDSTLMAQACLRMRTSCDSHGANLDLRSVLVSFFLHVYHAKVNQRNSSMMFIQEAMTGARILRLNEDILHEEDEVISNQALVFPLLWVSERGYSLHLGLSPSYIDPPVLIHLEGDMNADVHAQGLLELVKLFIAFDQISVRRNSRPGIIMATHLTNTEVKVASLCFSMANHVSTRTADYHITREWMRTILWQEALNMNLLSSSACEPVLAFGFPAQVGRALLQALRGFSETDLLPLGRDQAIIEVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W6R423</accession>
    <name>W6R423_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transcription factor, MADS-box</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S05g000385</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6R423"/>
    <dbReference type="OrthoDB" id="4290543at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036879">
        <property type="entry name" value="TF_MADSbox_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55455">
        <property type="entry name" value="SRF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM36552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="123" mass="14555" checksum="7E8A1C3785ADD62A" modified="2014-04-16" version="1">MAPVESPIKQEQLRKRRIKQEQLRKRRNNLLRRHNDFWRLYSIKSWVVMEMPNGRLYTYYSHPDVAVPTKQEIAQRPQPAVHKSPPDYGPHESANEAIPKLPAITVLGRCNELWSTLSHYITR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W6R551</accession>
    <name>W6R551_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Mtf2-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S05g000785</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6R551"/>
    <dbReference type="STRING" id="1365484.W6R551"/>
    <dbReference type="OMA" id="TNINRLC"/>
    <dbReference type="OrthoDB" id="2444174at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043837">
        <property type="entry name" value="Mtf2-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040009">
        <property type="entry name" value="Mtf2/C5D6.12-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39468">
        <property type="entry name" value="CHROMOSOME 7, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39468:SF1">
        <property type="entry name" value="MTF2-LIKE C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19189">
        <property type="entry name" value="Mtf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mtf2-like C-terminal" evidence="2">
        <location>
            <begin position="259"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="295"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM36952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="483" mass="54299" checksum="D60B7ACC0CD67E8C" modified="2014-04-16" version="1">MATNINRLCLLSRSNSTAPFLYQTRTLTPLSSAARNQFNRRFPRSFSTQNNAEANDATENKSLAEDNTSQNASEQPITNSSKTEAAPKPRRSYLQKRAASVSERPSLRPSVVKKTTKIAPKITSQEKLIFGGLLEQLGFKHDGETTEASSSTPMSEEKKAEMAELMSVFDNLLKDPRRKRADTKAKQQAKDDYSSYRRPEKSETEEQVPAENQGPKRIKLRDLGYTEPATATAAEVTVSLRRAIEIVVQAESEHIEFALFQAIEEGKGDLGVWEVCKERIFSMLRHLDEKSLVEASDPESVSTADQPEPPTRPSGPFRVPAVVPVAPVVVALYPKTLLIAFRVLNTHFRESPLIPQFRSTIKEYGRVSTFLGASSGLYDELIHYHWRVCKDLPAVTSILREMNQLGINPSSKSRGMLTALIIRHARDVEAHRTSPSEKDFFWDIPSNKEAFDELTRKDGWMDQIEARSEEEAKQREAALTFRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W6R713</accession>
    <name>W6R713_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DNA methylase, N-6 adenine-specific, conserved site</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S06g000594</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792020">
        <property type="protein sequence ID" value="CDM37632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6R713"/>
    <dbReference type="STRING" id="1365484.W6R713"/>
    <dbReference type="OMA" id="MPRIPYS"/>
    <dbReference type="OrthoDB" id="269872at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050320">
        <property type="entry name" value="N5-glutamine_MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18895">
        <property type="entry name" value="HEMK METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18895:SF74">
        <property type="entry name" value="MTRF1L RELEASE FACTOR GLUTAMINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM37632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="365" mass="41054" checksum="A18DD594A62B9624" modified="2014-04-16" version="1">MPRIPFSVIIKAQRENNLLPILLKECRTIDSARNELRWLRERAVRDSQSLPSKAGWRSRLRSMCRMRSRGYPLQYILGDQPFGDLEILCRRGVLIPRPETESYTYQAANLVRQMALGHNDKSKSPNQARPLRVIDLCTGTGCIPLLLHALLCPHFQELEITGVDISPTALDLARENLEHNLQLGQLAPRAGTDIHFYRADVLGHNSDNSVPSIESMLQTQHPNLGALDISSPDQESECDLLISNPPYISQTDFRNGTTARSVRRFEPKLALVPPYLGSGMEDCMPEDIFYHRILTLALKLKAKLTVLECGDSHQANRVVALHKRLASAESGQSRAEVWPSREQDLADNGFHETDGSRGVIIRTLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W6R8W7</accession>
    <name>W6R8W7_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="6">FAD-dependent pyridine nucleotide-disulphide oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PROQFM164_S10g000076</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAD-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792024">
        <property type="protein sequence ID" value="CDM38262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6R8W7"/>
    <dbReference type="STRING" id="1365484.W6R8W7"/>
    <dbReference type="OMA" id="PIPFKQS"/>
    <dbReference type="OrthoDB" id="202203at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004174">
        <property type="term" value="F:electron-transferring-flavoprotein dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43735">
        <property type="entry name" value="APOPTOSIS-INDUCING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43735:SF3">
        <property type="entry name" value="FERROPTOSIS SUPPRESSOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="5">
        <location>
            <begin position="5"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDM38262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="390" mass="41300" checksum="3AEDD63B5372E515" modified="2014-04-16" version="1">MAPIDVVIVGGSFAGLHIAHSVLRDVPDAKVVLINPSTSFFWNIAAPRIVAKPKAFRPEQYLLPIKEAFASYRPDAFEFLPGVATAIDTTAKSVSVTPNEGEPKTLPYDYLVIASGSTTSATTGSLTGTSIPFKQSNRDDMEQLIESAQEIIAGAKEIVIGGAGPIGVELAGELADAVEQSGNTNKVSITIVSATDRVLPMLKSSASSAARKQLEHKKVKVVTSKRVIGVETPADDSSNWTVSLEGGDKLSADLYIPTTGATPNNSFIPTQFLDKDGWMKVNNEMRVQSTDGSTLPIFAAGDITNFSMRLSFKAIEQAHVAAANLKAAIVGGTAIKTFDQGDSIMMVVPIGETGGTGQIFGFVPFGFMVKMIKGKHYFIEKADSVLTGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W6PRK6</accession>
    <name>W6PRK6_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PROQFM164_S01g000309</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PRK6"/>
    <dbReference type="STRING" id="1365484.W6PRK6"/>
    <dbReference type="OMA" id="PETWQPK"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11059">
        <property type="entry name" value="CYP_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000115">
        <property type="entry name" value="Cytochrome P450 monooxygenase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6 7" id="KW-0408">Iron</keyword>
    <keyword evidence="3 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="466"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM26500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="519" mass="58812" checksum="AF212A7A4669A379" modified="2014-04-16" version="1">MAYSITALAAAFFAGLIFYRVFIYPVFLSPLSKIPNVHWSASISPAWMLWRRFTSRNNRTIQAAHERLGPIVRLGPSEISINCVDGGIKTVYAGGFEKHDWYPRVFGSFGTVSMFTMTGSKTHSTRKRMLSNIYSKSTLQTSPHMRIVSDTVIFDRLLPILQEVSKSGKSIDMHDLDQGLTMDFVSSYLFGLQNGTNYLQDDSVRKHWLHLYMCRKPFEFYAQEVPYLNGWLRRIGLRVIPKYCDDANEMLDAWALDLCDRAEQMISSTEPGIEPTVYKQLKQSLDKHSTKNGEAKPDKAQQRLDIACEMYDQLTAGFETSAVGLTYLFWQLSLHPEVQNKLREELLTLNPPILYPKTADLPPAKSIDSLPLLEAIVTETLRLHAPIPGIQPRVTPSPSCILAGYADVPPNTRVNAQAYSLHRNPEVFPEPETWQPKRWLEAENSPADLEEKRRWFWAFGSGGRMCVGSNLALQEMKLAVAAIYTNFRTTIVNDDNIEAIDAYTVKPTGDKLILKFESV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W6PRV1</accession>
    <name>W6PRV1_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Calcineurin-like phosphoesterase superfamily domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g000295</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PRV1"/>
    <dbReference type="OMA" id="IKTRICM"/>
    <dbReference type="OrthoDB" id="630188at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051693">
        <property type="entry name" value="UPF0046_metallophosphoest"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12905:SF0">
        <property type="entry name" value="CALCINEURIN-LIKE PHOSPHOESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12905">
        <property type="entry name" value="METALLOPHOSPHOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="1">
        <location>
            <begin position="7"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM26486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="345" mass="38201" checksum="C0BD5522855CCF75" modified="2014-04-16" version="1">MATIKTRICMISDTHTSTPHPPQRTDYAYRYPLPKANILLHAGDLTKVGYRVEHEAMIAMLIDADAELKLVIAGNHDITLDEEYFTTFGYTRHQRPEQLGEESILLSDDNLQTTLRTSSAKTPNTDSLKTYARSIKALWTSESARNAGIIYLEEGIHSFTLSTGAKFTLYASPYQPEFYNWAFAYPRDQDRYNPAPAALPQPQNPIPDYPAIDILLTHGPPAGVLDQVPPDLSVGCEHLLRAARRARPRLHLFGHIHEGWGAQRGVWDDKAGGDGDGGVRLEDVATDMEEMLENRGAFCDVSAGADRPLRVGEETLFVNGSIMTVAYEARNAPWVVDLELPVAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W6PS72</accession>
    <name>W6PS72_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WD40/YVTN repeat-like-containing domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PROQFM164_S01g000410</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PS72"/>
    <dbReference type="STRING" id="1365484.W6PS72"/>
    <dbReference type="OMA" id="HWTQPDP"/>
    <dbReference type="OrthoDB" id="1284551at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000561">
        <property type="entry name" value="Putative WD repeat protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045159">
        <property type="entry name" value="DCAF7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19919">
        <property type="entry name" value="WD REPEAT CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="350"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="393"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="506"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="314"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="439"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="547"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="29"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="82"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="449"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="550"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDM26601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="613" mass="65584" checksum="4E5380CD25A81303" modified="2014-04-16" version="1">MSNPASYDAHRRSAVFSRQPEELHIPSTGPINPNSSRQSSSHDYPATSDAGARLPSINVQQSSQYGGDGNISSSALPGALQPGNQNRPAVVSINTAPSVVPTMQQSSSQTNHRASMINSHGHSRSSPAGFDQSMYKQHTAPDGSKYPSSPGAFPPHTPQGSKYSPLGLADIRPSGEHMLSEALMNPGMSSMSYNNGDNQVPTNSNYVAPWPIYAVDWCKWPITGNSGFGGKLAMGSYLEDSHNYIQILDTHWTQPDPDTPDAAAGEIKLDYVKTAEATHSYPVTRILWEPPSSQKQSTDLLATSGDHLRLWSLPNSQPLQSSNSITRTANQRDPATSKLSPLALLSNSKSPEHTAPITSLDWNTISPSLIITSSIDTTCTIWDIPTLTAKTQLIAHDKEVYDVRFCANSVDVFVSCGADGSVRMFDLRSLEHSTIIYEPTDKSEKPVMSPGSSSPPGQSQTGLYPPPLLRIAASPHDAHLLATFSQDSSVVRVLDVRQPGQALLELKGHSAALNCVEWSPSRRGILASGGDDSMVLLWDLINQHNAAPIASPPSVTPGAPPSTTSERGPAGVWQSEYEVSNISWSPQGGPNHTGQPREWLGVCGGRGLTGVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>W6PT53</accession>
    <name>W6PT53_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="21">Acetyl-CoA carboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">cut6</name>
        <name evidence="21" type="ORF">PROQFM164_S01g000869</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>N(6)-biotinyl-L-lysyl-[protein] + hydrogencarbonate + ATP = N(6)-carboxybiotinyl-L-lysyl-[protein] + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13501"/>
            <dbReference type="Rhea" id="RHEA-COMP:10505"/>
            <dbReference type="Rhea" id="RHEA-COMP:10506"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83144"/>
            <dbReference type="ChEBI" id="CHEBI:83145"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.14"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>hydrogencarbonate + acetyl-CoA + ATP = malonyl-CoA + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11308"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.4.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1365484.W6PT53"/>
    <dbReference type="OMA" id="PTPKGHC"/>
    <dbReference type="OrthoDB" id="14612at2759"/>
    <dbReference type="UniPathway" id="UPA00655">
        <property type="reaction ID" value="UER00711"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003989">
        <property type="term" value="F:acetyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004075">
        <property type="term" value="F:biotin carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001295">
        <property type="term" value="P:malonyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06850">
        <property type="entry name" value="biotinyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.460.10:FF:000001">
        <property type="entry name" value="Acetyl-CoA carboxylase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000005">
        <property type="entry name" value="Acetyl-CoA carboxylase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000005">
        <property type="entry name" value="Acetyl-CoA carboxylase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000003">
        <property type="entry name" value="acetyl-CoA carboxylase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.20:FF:000005">
        <property type="entry name" value="acetyl-CoA carboxylase isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000010">
        <property type="entry name" value="acetyl-CoA carboxylase isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.460.10">
        <property type="entry name" value="Biotin dependent carboxylase carboxyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1770.10">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049076">
        <property type="entry name" value="ACCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049074">
        <property type="entry name" value="ACCA_BT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013537">
        <property type="entry name" value="AcCoA_COase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001882">
        <property type="entry name" value="Biotin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011762">
        <property type="entry name" value="COA_CT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CPAse_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45728:SF3">
        <property type="entry name" value="ACETYL-COA CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45728">
        <property type="entry name" value="ACETYL-COA CARBOXYLASE, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08326">
        <property type="entry name" value="ACC_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21385">
        <property type="entry name" value="ACCA_BT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="Rudiment single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00188">
        <property type="entry name" value="BIOTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50980">
        <property type="entry name" value="COA_CT_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0092">Biotin</keyword>
    <keyword evidence="9" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="5 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="18">
        <location>
            <begin position="46"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="17">
        <location>
            <begin position="198"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoyl-binding" evidence="16">
        <location>
            <begin position="681"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase N-terminal" evidence="19">
        <location>
            <begin position="1506"/>
            <end position="1848"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="20">
        <location>
            <begin position="1852"/>
            <end position="2167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="426"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="CDM27060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="2273" mass="253608" checksum="978EC7F9CDCD72B7" modified="2014-04-16" version="1">MSITNGNGSTVSKQDIPSHFIGGNALESAPPSVVKDFVAAHEGHSVITSVLIANNGIAAVKEIRSVRKWAYETFGNERAIQFTVMATPEDLTANADYIRMADQYVEVPGGTNNNNYANVELIVDVAERMDVHAVWAGWGHASENPRLPESLAASPKKIIFIGPPASAMRSLGDKISSTIVAQHAGVPCIPWSGTGVDAVKLDEHGIVTVEDEVYKKGCTFSPEEGLAKAKEIGFPVMVKASEGGGGKGIRKVENEEEFYALYNAAANEIPGSPIFIMKLAGNARHLEVQLLADQYGNNISLFGRDCSVQRRHQKIIEEAPVTIAKQPTFQAMERAAVSLGRLVGYVSAGTVEYLYSHSDDKFYFLELNPRLQVEHPTTEMVSGVNLPAAQLQIAMGVPLHRVRDIRLLYGVDPNASTEIDFDFSKEESFQTQRRPQPKGHTTACRITSEDPGEGFKPSSGTMHELNFRSSSNVWGYFSVGTAGGIHSFSDSQFGHIFAYGENRSASRKHMVVALKELSIRGDFRTTVEYLIKLLETPAFEDNTITTGWLDQLISNKLTAERPDQNVAIICGAVTKAHLASEAGIEEYRNGLGKGQVPSKEILKTVFPVDFIYEGERYKFTATRASLDSYHLFINGSKCSVGVRALADGGLLVLLSGRSHNVYWKEEAAATRLSVDGKTCLLEQENDPTQLRSPSPGKLVKFTVENGEHIRSGQSYAEVEVMKMYMPLIAKEDGIVQLIKQPGATLEAGDILGILALDDPSRVKHAQPFTGQLPELGSPTVLGNKPSQRFFLLHSILENILRGFDNQVIMGTTLKDLVEVLRNPDLPYGEWNAQSSALHSRIPQRLDTQLQNVVDRAKARKAEFPAKQLQKAIVRFIEENIGPADAEILKATLLPLVQVINKYMDGLKSNEYNVFIGLLEQYYDVEKLFSTHNLRDEDVILKLREENKDDITSIVHIVLSHSRIGSKNNLVLAILDMYRPNQPLVENVGTHFKPILKKLTELESRSSAKVTLKAREVLIQCAMPSLDERLSQMEHILRSSVVESRYGETGWEHREPSLDVLKEVVDSKYTVFDVLPRFFVHADPWVTLASLEVYVRRAYRAYTLEGIEYNASNEQPFLSWDFTLGKLGQREFGVLNSTQPSAPGTPITEVNPFKRINSIGDMSLFVSDAASDPVRKGVIIPVQYLEDAEELLSKALEVFPLGGSNIKRPIEQGLIASLEGKRRPGLKPVSDSELTGVCNIAIRDIEDMEDAELVEQMKQLLADNKDELLARRIRRVTFICGKQGVYPGYFTFRGPHYEEDVSIRHSEPALAFQLELGRLSKFNIKPVFTENRNIHVYEAIGKGVENDKTIDKRYFIRAVVRPGRLRDDIPTAEYLISEADRLMNDILDALEIIGNNNSDLNHIFINFSPVFNLQPVDVEQALAGFLDRFGRRLWRLRVTGAEIRILCTDPATGMPYPLRVIISNTYGFIINIELYIERKSEKGEWIFQSIGGTAKLGSMHLRPVSTPYPTKEWLQPKRYKAHLMGTQYVYDFPELFRQAFQNSWTKIAEKIPSLYEKRPPVGECIDYSELVLDDTDNLVEVSREPGTNTHGMVGWIVTARTPEYPRGRRFIIVANDITFQIGSFGPQEDKFFHKCTELARKLGIPRIYLSANSGARIGVADELIPFFSVAWNKPEKPEAGFKYLYLTPEIKKRFDASKKKEVITELINDEGEERHKITTVIGAKDGLGVECLKGSGLIAGATSKAYEDIFTITLVTCRSVGIGAYLVRLGQRAIQVEGQPIILTGAPAINKLLGREVYTSNLQLGGTQIMYKNGVSHMTATDDFEGVEKIVEWMSFVPDKKNAPIPIRPWSDTWDRDIGYFPPPKQAYDVRWLIGGKEDVDGFLPGLFDKGSFEEALGGWARTVVVGRARLGGIPMGVIAVETRSVENVTPADPANPDSMEMISTEAGGVWYPNSAYKTAQALRDFNNGEQLPVMILANWRGFSGGQRDMYNEVLKYGSYIVDALVKYEQPIFVYIPPHGELRGGSWVVVDPTINPDQMEMYADEESRGGVLEPEGMVNIKYRREKQLDTMARLDATYGELRRSLADTSLTHEQLSSVKANMAAREEQLLPVYMQIALQFADLHDRAGRMQAKKAIRKPLQWVNSRRFFYWRLRRRLSEETIVKRMVAASAPPAPGADAFGETPRAAHLRTLHAWTGLLDEELEHNDQKVAAWYEENKKVIHSKVESLRTDGVASEVAQLLIGNKEGGLRGVQQVLSMLPVEERENVLKYLGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>W6PTF4</accession>
    <name>W6PTF4_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA-directed RNA polymerase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">RPB9</name>
        <name evidence="15" type="ORF">PROQFM164_S01g000850</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9 13">Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PTF4"/>
    <dbReference type="STRING" id="1365484.W6PTF4"/>
    <dbReference type="OMA" id="DTSMVLF"/>
    <dbReference type="OrthoDB" id="282270at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001193">
        <property type="term" value="P:maintenance of transcriptional fidelity during transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006283">
        <property type="term" value="P:transcription-coupled nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10508">
        <property type="entry name" value="Zn-ribbon_RPB9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.10:FF:000008">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.10:FF:000016">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012164">
        <property type="entry name" value="Rpa12/Rpb9/Rpc10/TFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001529">
        <property type="entry name" value="Zn_ribbon_RPB9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034012">
        <property type="entry name" value="Zn_ribbon_RPB9_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001222">
        <property type="entry name" value="Znf_TFIIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239:SF1">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02150">
        <property type="entry name" value="Zn_ribbon_RPB9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01096">
        <property type="entry name" value="Zn_ribbon_TFIIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005586">
        <property type="entry name" value="RNApol_RpoM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00661">
        <property type="entry name" value="RPOL9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00440">
        <property type="entry name" value="ZnF_C2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51133">
        <property type="entry name" value="ZF_TFIIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9 13" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4 10 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9 13" id="KW-0804">Transcription</keyword>
    <keyword evidence="6 10" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIS-type" evidence="14">
        <location>
            <begin position="88"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="11">
        <location>
            <begin position="24"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="24"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR005586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR005586-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR005586-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CDM27041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="128" mass="14138" checksum="4B8A2B5E42464DA8" modified="2014-04-16" version="1">MSASPSSTAGGETKPSDRIHFKFCRECSNLLYPKEDRVNNRLMFTCRTCHVGEPASSHCVYQNHLHSQVGDTAGVTQDVTSDPTLPRANKLCPSCGETEAVFFQSQQRSAETGMKLYYVCCACGQVYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W6PTS3</accession>
    <name>W6PTS3_PENRF</name>
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        <submittedName>
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        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="8 9">
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        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
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                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="project" value="UniProtKB-SubCell"/>
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    </dbReference>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Zn2Cys6_DnaBD"/>
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        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zn_clus"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
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    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
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        <location>
            <begin position="9"/>
            <end position="39"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="92"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="100"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="524" mass="58787" checksum="FB34360239215CED" modified="2014-04-16" version="1">MPGAKNTQCCDPCRVLHHKCDGILPQCSRCIRTGRECARSKKETKFRQAKGRTTRTKFPSNQVWLRPPPRVDFVLENGSGQVDNSTQTTLNVLSPGNLHSHADSIPKPERLSPGSSYTAPLPQHDSPNYEVYTRSSAISPTLQVVSTPERSHRRPWPLRDPEEARLLRHFVEKVAPFFDCTDRQQHFAIHIPYRARRCETLFNAILAMSARHLNRTTGFDPFVSDNYYQACLEKLIPALDDHGVTMDDDLLAATVILRLLEEFDVPLAGSDIRGHSFGTKAFIRCPSMMTTTPSLRQAVYWSGLRQEIYNSLSLHQAPDIDLRSFDLNFHSNSLGSDAGDCAWANQAITHCAHVLVFCFGKGPRSAAVHAELTAHNQQWSETRPNSFDPYFVGEDVVVGTEFPDIRYSCPWHAIGNQYIDLAQILLSVHDPTLPTVGPLRRGLIQEADDHIRRGVWTLCGASLSNASVPPAMVVGCMAIHLCGDRFTDPHEQDHLIQVLIQTDTLHGWPTHALQGQLWDTWGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W6PU94</accession>
    <name>W6PU94_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PfkB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S01g001266</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PU94"/>
    <dbReference type="STRING" id="1365484.W6PU94"/>
    <dbReference type="OMA" id="CDYVVFS"/>
    <dbReference type="OrthoDB" id="204058at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052562">
        <property type="entry name" value="Ketohexokinase-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42774:SF3">
        <property type="entry name" value="KETOHEXOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42774">
        <property type="entry name" value="PHOSPHOTRANSFERASE SYSTEM TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00584">
        <property type="entry name" value="PFKB_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="3">
        <location>
            <begin position="207"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM27455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="307" mass="33654" checksum="55B4158D18B92604" modified="2014-04-16" version="1">MALVAIGACYLDTILTAPYYPNEDEKLRATRISRRRGGNCPNTLEVLSQLLQYRPSSAESSLNLIAVLPSKSSMASQQIQSSLGNEVWLDKCIYRESFSEPASSYIITSQATGSRTIVNYNELPEMTHPEFAAAVEPLHAGRAPDVTLECIHYIRMHFPEAKISVEIEKPGRPGLQGLADAADVVIYSKGWAQKNGYTCAEDCLRDQSLKTSGASLLCCTWGHDGAAALEPKTGKFAHVPAHTEEMGVVDTIGAGDTFNAGLLYGLVYRDHDWDFRKKLEFANTIAGLKVTQEGFANLQRALNFPSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W6PUH2</accession>
    <name>W6PUH2_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S01g001346</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PUH2"/>
    <dbReference type="STRING" id="1365484.W6PUH2"/>
    <dbReference type="OMA" id="VHINHIA"/>
    <dbReference type="OrthoDB" id="4356969at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM27535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="111" mass="13098" checksum="6D7A9F3B90A8E70D" modified="2014-04-16" version="1">MRDSNEFPVGLRRDSFLYVDQDSLQSCDVPRPFVWLLEPDNENIAKPLKVHINHIAPTLFARFTQRDLSPEVNRQPYRNISELKMLHKAARWSKDAPGEKDRIWPPPVRFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W6PVQ5</accession>
    <name>W6PVQ5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g002109</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PVQ5"/>
    <dbReference type="OMA" id="NLTATWI"/>
    <dbReference type="OrthoDB" id="5426563at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM28298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="246" mass="27262" checksum="E95B74B4B142EB43" modified="2014-04-16" version="1">MNWTGGQLQRHHTRSGLLTKAQKQNFARSRLQKGTVISPPSPFRNFPDEFKGSSTREDEGAETNENQVPEESDSHLTGQTSHGDSGHGDSGLTGVKRQLLKEPDVAAVSAARPLDLAFTSVGDVERFGKRRKLNDKNRNRRVAANNNGSAFFERPRSQRRGRNPSSVIDTIEEDIQFEIDGRPVAQSNGSSGVVMNSMSSQSMLLDHEESPVTEQDMGKENLTATWITNLYPRSQFPQRGAMPSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W6PW64</accession>
    <name>W6PW64_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Nucleolar, Nop52</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PROQFM164_S01g002289</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PW64"/>
    <dbReference type="STRING" id="1365484.W6PW64"/>
    <dbReference type="OMA" id="AMWFSDR"/>
    <dbReference type="OrthoDB" id="2019504at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010301">
        <property type="entry name" value="RRP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13026">
        <property type="entry name" value="NNP-1 PROTEIN NOVEL NUCLEAR PROTEIN 1 NOP52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13026:SF0">
        <property type="entry name" value="RIBOSOMAL RNA PROCESSING 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05997">
        <property type="entry name" value="Nop52"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="131"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="158"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDM28478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="318" mass="36643" checksum="D57DFC7588DFBDA1" modified="2014-04-16" version="1">MDGQKTPFVRELGSSDRKVRDKALESLTKFVQSRTDLTLVDLLKLWKGLFYCFYHSDRPLTQQALARALSYSLVPSLPHATLHRFLRAFWITIGRDYHSLDRIRLDKYLMLIRFYVGVAFEVLVKNKSSTKNADGKKRKREDAAKQGRGKKQKKQAEAEAETAEDEEEKDSAEDLEAKFPDLAAYISIIEEGPLCPLNYDEDQAPDEGDPNYVPMPHGPDGLRYHLIDIWVDELEKVLEFEEVAGEDEEETPKRKIKGDVPIELILRPLEKLRAESAYKPVRTRAAEALEDERLIEWGVRTRKADEEDDSEEEWGGFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W6PWR6</accession>
    <name>W6PWR6_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g002047</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PWR6"/>
    <dbReference type="STRING" id="1365484.W6PWR6"/>
    <dbReference type="OMA" id="WMHDDAL"/>
    <dbReference type="OrthoDB" id="2245989at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021833">
        <property type="entry name" value="DUF3425"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38116:SF8">
        <property type="entry name" value="BZIP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38116">
        <property type="entry name" value="CHROMOSOME 7, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11905">
        <property type="entry name" value="DUF3425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="60"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM28236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="286" mass="33245" checksum="64233DC7ADB7BC44" modified="2014-04-16" version="1">MTESSTVDQIPISDDAEQKADNGSALSDPIERRRRQNRINQRAHRERKRLSLIKNIHQKSLVSSSSSTSNVQTQDHSSQDRSSQDNPKVNFNRSSEFLHNTLEKFAKSAYESYIRGDPSTDHLMTLTKVNVFRGFMQNLRLIGWSEYWIDLDVISPFSIASPQTPPHMDDNSLLPISLQPTRIQKSIHHHPWLDLFPLPKMRDNLIEAGDEWDDEQLCHDIMGFWGDSTMDAGLLVWGDPWNVQNWEVTEGFLKKWQWVIRGCPELMNATNSWRARRGERLIFRYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W6PWY1</accession>
    <name>W6PWY1_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Probable transposable element</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S01g000283</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PWY1"/>
    <dbReference type="OrthoDB" id="4369552at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM26474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="65" mass="7590" checksum="A879F4EC4237A858" modified="2014-04-16" version="1">MLDQCGKIPQNACPRHQILPIRWVFKYKSDENGFLTSFEARICVRGNLQIIEDKEEVRAVGVWQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W6PWZ1</accession>
    <name>W6PWZ1_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Small-subunit processome, Utp14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PROQFM164_S01g000293</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PWZ1"/>
    <dbReference type="STRING" id="1365484.W6PWZ1"/>
    <dbReference type="OMA" id="QVIEPMD"/>
    <dbReference type="OrthoDB" id="277439at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006709">
        <property type="entry name" value="SSU_processome_Utp14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14150">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14150:SF12">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 14 HOMOLOG A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04615">
        <property type="entry name" value="Utp14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="467"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="621"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="855"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="66"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="111"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="137"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="158"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="217"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="272"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="469"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="494"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="539"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="568"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="621"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="661"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="681"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="711"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="723"/>
            <end position="732"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDM26484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="957" mass="108078" checksum="CDE177CDACDE4CFA" modified="2014-04-16" version="1">MPRSQTQKQGPKDRSTQKSAPKRKSTRSLNALSIAEKTIHTRLGVKRSRLGAYDDGTFNRRRNTGGDDDDNDEEDTAAQYKRRRTEDTGSLDGGSDSEGHEWTLGQVNSDNDSELDSDEALGESDEERFEGFTFRASKSKSHPKKAPPKPKKPTEINLSEDVDESDEESDGDDYDEDDDLGEDAVDLATAWDMNAAAEEEEAQEAAAKSKRAAKYDSDEDSGSEGDSESDDSDDGLSISDDDADVDPHGLSKLQDFVQSMETEKPTKRTQKSQEQGKPSEYGLTTANKLTVADLLPSITDSRLKNSLKHIDSVVQASKSGIPGKLDAPLAKRQQDRLDRAAAYEKSKETLNRWLETVKANRRAEHLSFPLRDPDAEQTHRLEAAKPQTDLENVIQNILVESGLAEAEGKSAEDQIQSFEELQARNLPIEEIQARRAELRKRRDLLFREEVRAKRIKKIKSKSYRRVHRKEREKIEQQEHNALLEAGVDMDDMDQEKNERMRAEARMGSKHRESKWAKGLKQTGRTAWDEEARNSAADLAQREEELRKRIEGKRVSNGDDDYLGSSSSESEDEDPWNEEASDVERQKIQKKLKALEGSDDAGDGMKGRHADLFEMKFMKNADAARKEQNDAELRQLNRELRGEESASEAESEVGRRKFGQSKKTDPKPRAKQLPKNEFEEKLDSDDEAAQAAGADDDVDIVMNGTTKHKSGASGNKKVSQSSRHSPDRQKDTPVEEENPWLIQTERTNRRRTGPDAQESIDISLDATQPEVIPVEQQSKKQKKTKAALAKQQFDENDSDDEEKVPVLLKNHDLVKRAFAGDEVVQEFEQDKMDTIKDEGDQVVDNTLLGWGSWAGEGVSKRQQRKQKRDLTTVAGVKPQQRKDAKLDRVIINQKRVQKNKKYMASQLPHEFETKQQYERSLRLPLGPEWSTKETFQSGTKPRVMIKQGVIKPMSKPMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W6PYQ6</accession>
    <name>W6PYQ6_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DNA ligase</fullName>
            <ecNumber evidence="12">6.5.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">cdc17</name>
        <name evidence="16" type="ORF">PROQFM164_S01g000903</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>ATP + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP + diphosphate.</text>
            <dbReference type="EC" id="6.5.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 13">Belongs to the ATP-dependent DNA ligase family.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.1" evidence="12"/>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PYQ6"/>
    <dbReference type="STRING" id="1365484.W6PYQ6"/>
    <dbReference type="OMA" id="WIKYKRD"/>
    <dbReference type="OrthoDB" id="206088at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003910">
        <property type="term" value="F:DNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903461">
        <property type="term" value="P:Okazaki fragment processing involved in mitotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07900">
        <property type="entry name" value="Adenylation_DNA_ligase_I_Euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07969">
        <property type="entry name" value="OBF_DNA_ligase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3260.10:FF:000004">
        <property type="entry name" value="DNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000062">
        <property type="entry name" value="DNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.30:FF:000016">
        <property type="entry name" value="DNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3260.10">
        <property type="entry name" value="DNA ligase, ATP-dependent, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.30">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050191">
        <property type="entry name" value="ATP-dep_DNA_ligase"/>
    </dbReference>
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        <property type="entry name" value="DNA_ligase_ATP-dep"/>
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        <property type="entry name" value="DNA_ligase_ATP-dep_C"/>
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        <property type="entry name" value="DNA_ligase_ATP-dep_cent"/>
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        <property type="entry name" value="DNA_ligase_ATP-dep_CS"/>
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        <property type="entry name" value="DNA_ligase_ATP-dep_N"/>
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    <dbReference type="InterPro" id="IPR036599">
        <property type="entry name" value="DNA_ligase_N_sf"/>
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    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
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    <dbReference type="NCBIfam" id="TIGR00574">
        <property type="entry name" value="dnl1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="DNA LIGASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45674">
        <property type="entry name" value="DNA LIGASE 1/3 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04679">
        <property type="entry name" value="DNA_ligase_A_C"/>
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        <property type="entry name" value="DNA_ligase_A_M"/>
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        <property type="entry name" value="DNA_ligase_A_N"/>
        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF117018">
        <property type="entry name" value="ATP-dependent DNA ligase DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56091">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme, catalytic domain"/>
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        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00697">
        <property type="entry name" value="DNA_LIGASE_A1"/>
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        <property type="entry name" value="DNA_LIGASE_A2"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50160">
        <property type="entry name" value="DNA_LIGASE_A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="6 12" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8 12" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="9 12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="2 12 16" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-dependent DNA ligase family profile" evidence="15">
        <location>
            <begin position="583"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="840"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="19"/>
            <end position="30"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="38"/>
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            <begin position="71"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="101"/>
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        </location>
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            <begin position="115"/>
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        <location>
            <begin position="135"/>
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    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
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            <begin position="149"/>
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        <location>
            <begin position="840"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007572"/>
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    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
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            <dbReference type="ARBA" id="ARBA00022618"/>
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            <dbReference type="ARBA" id="ARBA00022705"/>
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            <dbReference type="ARBA" id="ARBA00022741"/>
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            <dbReference type="ARBA" id="ARBA00022763"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
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            <dbReference type="RuleBase" id="RU004196"/>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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            <dbReference type="PROSITE" id="PS50160"/>
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    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CDM27094.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
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    <sequence length="861" mass="94819" checksum="D27DC83E5508842E" modified="2014-04-16" version="1">MADDKSRKQATLGRFFGSGANQPPKKQTTLAFGGKRQAASSNAADTELTDNTNGFKVEDASNSAPTAEPTKGVKREKSPEAEESDGSDIQPVSKRRRKASSKSSPAAKKQSASPEKPESIKPKVESPSPKPAMKKLSDVTPEEKSPSVVEDEDPLESEDEDDLKPELTRKSIEKFQAKIQASGKDPYPDWEAGTPVPYAALCTTFSLVEMTRKRLEITDHCSLFLRQVLRLTPADFLPTVQLMINKLAADYAGVELGIGESLIMKAIGECTGRSLAVIKADQREIGDLGLVAAKSRSNQPTMFKPKPLTVRGVHEGLLGIAKVQGHGSQDKKISGIKKLLSAADADTAGKGGKGVDITKDKGGPSEAKFIVRFLEGKLRLGLAEKTVLVAVSRAVQIHEAESTGNKIPSTEQMAAGENIFKTVYSELPAYEVIIPAVLEHGLFKLPEVCKLSPGIPIKPMLAKPTKSITEVLDRFEGKEFTCEYKYDGERAQIHFVSPDSMHQYPGALETLQKDSKGLSSIFSRNSEDLSKKYPDVLGKLGTWVKADVKSFVLDCETVAWDTEAKKVLPFQQLMTRKRKDVKAEDVKVKVCVYAFDLLFFNGEPCVKKSLRERRELMHECFQPIEGEFQFAQYGNSNVLDEIQELLEASVKASCEGLMVKMLDTAESGYEPSKRSRNWLKVKKDYLAGVGDSLDLVVLGAYYGRGKRTSVYGAFLLAAYNPNNDTYETICNIGTGFSEVLLEELHQTLVPLVIDRPKPFYTHSAVPKDQPDVWFEPRLVWEVKTADLTLSPRYQAAADEFQGTTGGGKGVSLRFPRYMKSRDDKKPDEATTTRAVAEMYRKQEAVTKDTTSKGGVDDDFEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W6PYT1</accession>
    <name>W6PYT1_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">THO complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PROQFM164_S01g003240</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the THOC2 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:THO complex part of transcription export complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Tho2"/>
    </dbReference>
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        <property type="entry name" value="THO_THOC2_C"/>
    </dbReference>
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        <property type="entry name" value="THO_THOC2_N"/>
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    <dbReference type="InterPro" id="IPR032302">
        <property type="entry name" value="THOC2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21597:SF0">
        <property type="entry name" value="THO COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21597">
        <property type="entry name" value="THO2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Tho2"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Thoc2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="THOC2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="THO complex subunit 2 N-terminal" evidence="9">
        <location>
            <begin position="163"/>
            <end position="895"/>
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    </feature>
    <feature type="domain" description="THO complex subunitTHOC2 N-terminal" evidence="8">
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            <begin position="897"/>
            <end position="972"/>
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            <begin position="1250"/>
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            <begin position="1"/>
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            <begin position="1160"/>
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            <begin position="1573"/>
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            <begin position="1273"/>
            <end position="1325"/>
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            <begin position="62"/>
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            <begin position="122"/>
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        <location>
            <begin position="1586"/>
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            <begin position="1651"/>
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        <location>
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        <location>
            <begin position="1713"/>
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    </feature>
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        <location>
            <begin position="1814"/>
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    </feature>
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        <location>
            <begin position="1854"/>
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        </location>
    </feature>
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        <location>
            <begin position="1868"/>
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        <location>
            <begin position="1889"/>
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        <location>
            <begin position="2005"/>
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        </location>
    </feature>
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        <location>
            <begin position="2027"/>
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        <location>
            <begin position="2100"/>
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        <location>
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        <location>
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        <location>
            <begin position="2254"/>
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    </feature>
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        <location>
            <begin position="2269"/>
            <end position="2304"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00007857"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00019596"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF11262"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF11732"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF16134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDM29428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="2344" mass="260150" checksum="8D15974140BD1119" modified="2014-04-16" version="1">MAPGYGHGGKRKRIDRSWSGESGSNDLRPSPHRPGTLNMAHHPTNPGHQSPTPREQNDTRDRSRRQSHRNRAGSRRGSHDGQNFSNSQHREPNAMSPPAINQPRELADPVPYNGDSAASRPTPSPAPNTPAPQPQFNPPSRASSETVTPHPSLPPPPYDYEYVTDSAVEEWASAGKQKVVGEGTAARLEQDLARLASVYQELIHSAIYGRLSPSHAGNAVKNIIGEESVSQDVDMDSGKPLTLGIDPRSLFLDTLSIVTDADPSNAALKPLVFATGIDPSLMRLQLETPLLQSLGLVRETFARMGIRKQTNLLYRQSNYNLLREESEGYSKLITELFTTSNNEPPSSEVVMDTFERVKAMIGAFDMDVGRVLDVTLDVFAAVLVKQYRFFVKLLRVSSWWPKEEAVHRLEQGYRHSGIPNWALPGSTGWITTDEERSATMRANEERDSQFWDRVREIGLQAFFEIGRKPVPGVEVQRNLSEINGSSFEEDATRSWLEETGTIPPKGNRVAAQLLGFKLRFYSSSARTKDDVLPDNLIYLAALLIKVGFISLRDLYAHLWRSDDTMEILKTEKMAEKAERVKASRPGGGINALMMAGALSDDTIPPSRLRDEPRVATPSKDQESDKGTAKMENELPDPSDQKVLLLKSLLAIGAIPESLFIISKFPWLMEAYPELPEFIHRILHHSLKKVYIQFRPSVSTGDFPGAQYTVTSDQNNAKGQIGLTPPPSRRVLRWAQLDKEDTNDGTDYRFYWDDWADNIPICQSVDDVFALCSSFLNLSGHKIGQDASLLAKLVRIGKGSLIQDGSEANRTRWRDLCKRLLLPAVSLTKANPGVVNEVFDLISFFPRDVRYNMYAEWYSGQTSRLPDIKEAFDQARAETKDTLKRLSKTNIRPMARALAKIAYANPGIVINVAMSQIESYENLIEVVVECARYFTYLGYDILSWSLINSLGQKGRSRVQEGGLLTSRWLNALSTFAGRTYKRYSVMDPTPVLQYVVEQLRHNNSTDLIVLEQLISSMAGIISDNDFNDAQIQAMAGGDVLQSQTILQLLDKRHESKTTSKRLLKSLTHTRIAGQLLVAIAQERLTCVYNETSSELKLLGNIFDEIHRILTQYLDLLRSNLSVDEFDSFVPDFSSLVTEFGIQPEIAFWIRRPSIARKINDIEESKQEKERSVSVSKSNGDHKMDTTEDEEKPTKSETPADSAMDVDKDETTPTEGPDAILASAVNAEPLAANPVMQDLIDDVKSALPAETWGTIGAHFYATFWQLALYDVHIPQKSYEDEIDRLKRRVVSINSDRSDLSVAGTARKEHLKRQITQLQERILDENKNHLKAYGHTRSRLQKEKDKWFAGMRLKHDSLNVALLEQCFIPRLLLSPLDAFFSFKMLKFLHSSGTPNFRTVGLLDQLFREQRLTALIFLCTSKEADNLGRFLNEILRDLTRWHADKAVYEKEAFGAKRDLPGFAKNVDPEGVPVMFLEFEDFRRLLYKWHRLFSNALKSCLSSGEYMHIRNAISVLKAVVKHFPAVNWIGRNILNCVDHLSKNDERDDVKIPAASLIGDLNRREKKWMLPQAFYFAAAQPGSQPPGDASGTPGTPQSATTALNASAPEFNPTGSSISDNIAKQEQSGKTEVEDGEIEDAKMTDVGTGKGGEARRTGTPSQAGSTTPSMLTGEEATSGEQPPVRSRPNSRAPTSSRQPDIPKRPDIRQQVHPPVRPPPRHSDGRLPPRPEGLDDRRERHPDFGPRGRHGPDHNRSFDGSLGDVRGRLNEHLNERDREFPMRPAADDLMRGPPRDSRSTRENGWPMDRPGRMRGPGPNDSFHGRDPSVRGELMPDHMDRPVDIPRRGDSSRPEKDDRRPYPPRPLSPPRPVDLPNRPDRFPPPDDRRPAGFTPSSRIDDLPRGPRTDRQPDPRDAAPGPDMTHGRLRQPEPPSEIPAGPRRRGGRNMSGQAPPMLSSSNATLPAPERQTPTGPARQSGRGAPEQPAPPSQPAGSSTAPGIHPDRLRNLVNEPAAPAAAPSGPRGLGPQQPPRGPSAQSGQSGQSGQSGPPGPPGQGFGGERGRGDKRFAGLNNVLQQSGGGSGDRGGNTPVRGRGANRPPSTMEAPSPQPANRPPMGPAGPQEDQSRNRSNGGRGGDLLDDAVPEAGRSGSTGNRTRETEPTREKEPERREGSSNGRNRRDGRRNDRERSRRSDVGGGGSRDDKGTGEPRETLRRVQSSREELRRRDRRDRPDGPPGITGPTPSSETHDEGRVRPTSSMEAPPPPPPPPPPPMPEGNERRFNTGERGSRSDNRDRERERRGDRRDRDHQREGGSSGGSGHRKRGRQGPDDGTDGGRGMRMGNDNKRPRRGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W6PZH0</accession>
    <name>W6PZH0_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Histone deacetylase complex, subunit 2/3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S01g003465</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Component of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PZH0"/>
    <dbReference type="STRING" id="1365484.W6PZH0"/>
    <dbReference type="OMA" id="TTHSIEH"/>
    <dbReference type="OrthoDB" id="3647690at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070823">
        <property type="term" value="C:HDA1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038609">
        <property type="entry name" value="HDA1_su2/3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021006">
        <property type="entry name" value="Hda2/3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11496">
        <property type="entry name" value="HDA2-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="77"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="411"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="769"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="954"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1043"/>
            <end position="1097"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="94"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="782"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="801"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="954"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="969"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="981"/>
            <end position="997"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1049"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="1073"/>
            <end position="1086"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM29653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1097" mass="122420" checksum="E99515E358E3DEEF" modified="2014-04-16" version="1">MLPRIKNSTIVVISDSSESSDGSDLDDEEWPIKCILRETDTEYLIDWEGPYDPTWEPKENASELAIRVWNKQKARRSSALDRKSTSRRITQSPSVVEVSSSSSEENTGQGDSYRTTFDETEDTDSDNHSRASSSLFVQQDNISEIVDSLQSQYIEVSGCFYGTASLPQSPSTNPRLQADEYIPESPIPPEYPQRGEWDDVNTQQPGPYSAEINHVSELLSHPNTPGVGLSSNVSEIAETPVQPSSLGTDFSCPGSYPFYNTPSHNNLTFGSCGSILRDCVFVRSTYLSSIPETVCQNLSQHPEELSAEGFTRPMPSFSNLVQEEPFGEIMEDKEPKPSDPSLSAATLDRYGQLPGSTPTEMIRNAWAKLSEANQSELSQPANAVQTPSSVGDIEASMPVSIPETTALLSVRPDTDSFSNSHTAVHHGHSEPLLPPSELAHEAHMSQPSLQTIHPSALTVTDMDEVVAPGSVHLGPSEFAVPLPMNARVKDHYERVLSDAATCIRKFFDSFQSNTQVSEPEAKVLHSHMREVIARLSNVATYPDLNFANHLKNTDPDFAEEASWAEMSSAKFFLLGHFMKIVGTHELHLILAVQDEKKQGVLERYLQGKGFAYTRPRAEMGSTLEVSLAKGSLSFGIHSSETARELYKPPSAIFALDSYFKPKSPFIQHLRTTYARNGSLLPVIWFLVANTSEHIERCLPESPDPDRLRLLVHYIARFHDEAGELQDDALGASEDAEEILGYLLDSVAGWPLPTIKPLNLVSLEELECDSSSSDEAMPPAHKRTLDEKPDEHSSKRARIGTQEDSQLTESTKPPTQTLDRDLISLEKNIIQMKHIHASEKAQLQAELARANSGFREMERALGILQHRYESRTKELHVTRQERDRVVEHKPSLEQRVEKQKETISSLKQERAELKRELDEARQALKNGGGSNAELEMAREEIRRLTKENSNLERKAEFEKNQSEYTREQYQTASTAAAQSGTENRHLATENERLKRKAESNAVQLRELHMKDESVRHLARIEELELTLASRDEFLQRKEEELREIRKNRPSTRSTSTQPRSPKWAGSRPTSPGVGHNGNGNGGHGGRGSALRYSSEVPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W6PZY0</accession>
    <name>W6PZY0_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">Pre-mRNA-processing protein 45</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">prp45</name>
        <name evidence="6" type="ORF">PROQFM164_S01g003412</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Involved in pre-mRNA splicing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the SNW family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PZY0"/>
    <dbReference type="STRING" id="1365484.W6PZY0"/>
    <dbReference type="OMA" id="YGQRRGW"/>
    <dbReference type="OrthoDB" id="666364at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017862">
        <property type="entry name" value="SKI-int_prot_SKIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004015">
        <property type="entry name" value="SKI-int_prot_SKIP_SNW-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12096">
        <property type="entry name" value="NUCLEAR PROTEIN SKIP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02731">
        <property type="entry name" value="SKIP_SNW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="SKI-interacting protein SKIP SNW" evidence="5">
        <location>
            <begin position="193"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="224"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="324"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="521"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="235"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="327"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="367"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="388"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="521"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU367140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDM29600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="579" mass="65011" checksum="4271307BC87DCB45" modified="2014-04-16" version="1">MSTSIAAGLFKSLPKPKYSGEEEELPQHAQPRGPRVVGADQIDETQVVLRRTGPPPYGNRAGWRPRAPEDFGDGGAFPEILVAQYPLDMGRKGKSSKSNALALQVDAEGKVKYDAIARRGHADNRTVHASFKDLIPLRQRVDMGEISLEKPSEEEIQAQMERTKAALTTLVEGASSAQKPKNVKGGQRAEPTFVRYTPANQMGNTGRQNDRIMKIVERQLDPMEPPKFKHKKIPRGPPSPPPPVMHSPPRKLTAEDQEAWKIPPPVSNWKNPKGYTVPLDKRLAADGRGLQDVSINDKFAQFAEALFTADRHAREEVQLRAQMQQKLAEKEKAQKEEHLRMLAQKAREDRAGPSARVSRARSRSRSASRSVSVYSSRSATPSEDDEAARDRAEQRRERRREDERQLRQSRMGTERRIQTMAREQNRDISEKVALGLAKPTQSSESMWDSRLFNRTSGMQSGFNEDNPYDKPLFAAQDAINSIYRPRAQADADDEDAGEGEMSKLEKTKRFEVLGRAKEGFRGAAEAEERQGPVQFEKDTADPFGIDNMIADVTSGQKRYGIQEAEDVDRKSKRPRVDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W6PZZ8</accession>
    <name>W6PZZ8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Formylmethanofuran dehydrogenase, subunit A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g003651</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PZZ8"/>
    <dbReference type="STRING" id="1365484.W6PZZ8"/>
    <dbReference type="OrthoDB" id="3501663at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01300">
        <property type="entry name" value="YtcJ_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013108">
        <property type="entry name" value="Amidohydro_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033932">
        <property type="entry name" value="YtcJ-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22642:SF19">
        <property type="entry name" value="AMIDOHYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G01480)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22642">
        <property type="entry name" value="IMIDAZOLONEPROPIONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07969">
        <property type="entry name" value="Amidohydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase 3" evidence="1">
        <location>
            <begin position="110"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM29838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="576" mass="62997" checksum="EDF4E1D1816E57EC" modified="2014-04-16" version="1">MLHHLNVAQSHTANGIPCLCLICPRQLHQPNLNFNFDNSRSQLPLLPLLHHPSSLNRIIIVTTIFNNGRILCPGSWGRFVSTLVVEDDHLAHVGWDSDEAIVRVQATASTVDLRNRIVLPGFIDGHVHILNSGISLQKLDLLPCKNVADIQSSITTYAATHPSDPRILCRGWVQSVTDGNASATVLDDLDPRPIYIEALDLHSTWCNNAALKELEAESKPDPPGGKIHRYQNGTPSGLLEEAAQFDVVWPFLDRVMSMKNKVAAIDAAIRAHQRAGYTGLVDMAMGESGWVALNMYRNQRGELPMHVAVHWLVPYSKCDADICSHIDRAIEIQQTFNRKISSEFCINGIKLLCDGTVDGCTAGLHQAYGGLSNIVDPIWPADALSLAICRATNAGLQCVIYAVWDRTVQQAIDCLCQIQDLPACRHPIEHLEITTPEDAKRLGQLGIVASVQPVHLDPATFGGWPEMLEIQRCKRAFAYQEFVEGGAHLAFGTDSPTANHQALPNLYVATTRRSSIQPSLQDTINPECAVSLATAVSAATAGTAYASFSESWTGILRAGFKANFVVVDMIWAPESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q0R3</accession>
    <name>W6Q0R3_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Sea anemone cytolysin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S01g003368</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q0R3"/>
    <dbReference type="STRING" id="1365484.W6Q0R3"/>
    <dbReference type="OMA" id="SISHEYW"/>
    <dbReference type="OrthoDB" id="4791458at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.270.20">
        <property type="entry name" value="Cytolysin/lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015926">
        <property type="entry name" value="Cytolysin/lectin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009960">
        <property type="entry name" value="Fruit_body_lectin_fun"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07367">
        <property type="entry name" value="FB_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63724">
        <property type="entry name" value="Cytolysin/lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM29556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="207" mass="23628" checksum="7D3FC4A53BC10FAD" modified="2014-04-16" version="1">MRRRHYFISAPSDLFPAASISHEYWSLSPPLDSTRHYFSIRAFTLQQAALIHNPRSRYTSHTSILATMSYTIRLRVENSTSDALTVVEKTCWYYANGCTWTENDGQHVLFMGGSGTSGMLRFKSSFGEIFTIVVGIHNYKLWCGLLWDLGDQDTALKLHPEFYRGGKYSHATPDACYSPVTHATRASITFERENQNEVFAVLKYYPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q0T1</accession>
    <name>W6Q0T1_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S02g000049</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM29900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q0T1"/>
    <dbReference type="STRING" id="1365484.W6Q0T1"/>
    <dbReference type="OMA" id="HNTMSHH"/>
    <dbReference type="OrthoDB" id="4363784at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF11">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM29900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="52" mass="5687" checksum="EF1F75DA4CD8A887" modified="2014-04-16" version="1">MEAAGLMNDFPCLVIRGICDYADAHKNKEWQGYAAMAVAAYAKELVLVVPID</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q1Q3</accession>
    <name>W6Q1Q3_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AT hook, DNA-binding motif</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g001955</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q1Q3"/>
    <dbReference type="STRING" id="1365484.W6Q1Q3"/>
    <dbReference type="OMA" id="WAEHEKV"/>
    <dbReference type="OrthoDB" id="5371646at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="112"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="188"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="294"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM28144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="334" mass="36683" checksum="379C1DAB23D14CAE" modified="2014-04-16" version="1">MSNLSDRPWTEEDKCTLLTEILKKAGFPSSYLVRMIKEYGITPNWEHIPLPQGRSLSSCKTAYLNMVQQPVHPPTQPVASFPPPSDMTGPPAPMDPSTMRKRPLHPSDKPIPRAIQPRPPASTASYSSESGASAQLSPRLDVAPGEPPRKRGRPSKAETERRKLLAEARGETYPAPRRSGWSRRLKVPSSPTSPAAGPSSTPFPPAPQAFHGPKPSPAPTLYDTPTMHSAVLPPGPGPAPNDERRDMPPRMNINMRELPRPTEMVHPLPSPHALQLGPPDAFPRFSNPAERPYSFAADRFSPSDSSRRDSLTRPDQPAPYSERTNTTQAEKPPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q2G4</accession>
    <name>W6Q2G4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S02g000883</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q2G4"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM30733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="57" mass="6415" checksum="B85857EABE74181C" modified="2014-04-16" version="1">MCIFDSRVAKGVAPSLELAGHDFLRKREMEELLAVEQIPELGCFKPRAVRASKKNDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2024-10-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q375</accession>
    <name>W6Q375_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S02g001193</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q375"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM31043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="53" mass="5673" checksum="E74CBEF7D8A0D034" modified="2014-04-16" version="1">MPGMNASGASTFQSALGTDIHALRLEATVDFNSKRNILVVQAGQYPNRVVIVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q3C9</accession>
    <name>W6Q3C9_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thioredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">TRXA</name>
        <name evidence="7" type="ORF">PROQFM164_S02g000955</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the thioredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q3C9"/>
    <dbReference type="STRING" id="1365484.W6Q3C9"/>
    <dbReference type="OMA" id="HIHYVTD"/>
    <dbReference type="OrthoDB" id="10263751at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000245">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005746">
        <property type="entry name" value="Thioredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46115">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000077">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="6">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="32"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="35"/>
        </location>
    </feature>
    <feature type="site" description="Deprotonates C-terminal active site Cys" evidence="4">
        <location>
            <position position="26"/>
        </location>
    </feature>
    <feature type="site" description="Contributes to redox potential value" evidence="4">
        <location>
            <position position="33"/>
        </location>
    </feature>
    <feature type="site" description="Contributes to redox potential value" evidence="4">
        <location>
            <position position="34"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="5">
        <location>
            <begin position="32"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000077-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000077-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM30805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="106" mass="11245" checksum="A7F1C7CC6BF38B05" modified="2014-04-16" version="1">MGVTAITTAEEYKTKVTDATGLVVVDFHATWCGPCKAIAPTLEKLSDAHTNVKFYKVDVDDLAEVAAANAVSAMPTFRFYKNGELNQEVKGANPSAIQAGLKAILA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q3Q0</accession>
    <name>W6Q3Q0_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="11">General amino-acid permease GAP1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">GAP1</name>
        <name evidence="11" type="ORF">PROQFM164_S02g001110</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q3Q0"/>
    <dbReference type="STRING" id="1365484.W6Q3Q0"/>
    <dbReference type="OMA" id="AMAFIPD"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000017">
        <property type="entry name" value="Amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004762">
        <property type="entry name" value="Amino_acid_permease_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00913">
        <property type="entry name" value="2A0310"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF1">
        <property type="entry name" value="GENERAL AMINO-ACID PERMEASE GAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="84"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="112"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="191"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="221"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="263"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="304"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="359"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="405"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="435"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="477"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="513"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="10">
        <location>
            <begin position="81"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDM30960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="584" mass="63228" checksum="54AA6B9221717BD7" modified="2014-04-16" version="1">MDEKKFEEHTVQTGSDAPPSYGDSSPTRGGMGQRIIDSFKRDPNHTVLGTPGADGTAMDVEAAAAHNTAHSPLQRHLKGRHLQMIAIGGSIGTGLFVGSGSVLAVGGPASVLIAYILIGCMLYCTVHALGEMAVLFPVAGSFAHYSTRFMDPAWGFAMGWNYALQWLIVLPLEIVAASITVDYWSPGVSNAAWVTIFWVVIVSINMFGVRGYGEAEFVFSIIKVVAVLGFIILGIILNCGGGPEGGYIGARYWYDPGAFRNGFKGLCSVFVNAAFAFAGTELVGLAAAETANPRKSLPTAVKQVFWRIALFYVVSLTLVGLLVRYDDPKLISGSSSADAKASPFVIAIENAGIKALPSIMNVVIMIAVLSVGNSSVYGSSRTLAALAEQGQAPKFLAYIDRKGRPLPAIIIASALGLLCYLAASDVQTTAFEWMMAISGLSSIFTWGSICASHILFRRAWKKQGHTLDELAFRSQPGVIGSWVGLTFNILVLIAQFWVGFAPIGYGEMTSQEIAYNFFSVYLAAPVVLVSYVGYKIYYRCKFVKSLEVDLDTGRRDLDVQHLVEQELAEQKEWPKWKKVYKFFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q4D6</accession>
    <name>W6Q4D6_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S02g000941</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q4D6"/>
    <dbReference type="STRING" id="1365484.W6Q4D6"/>
    <dbReference type="OMA" id="GYQDWYT"/>
    <dbReference type="OrthoDB" id="5324692at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="69"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="341"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM30791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="739" mass="82285" checksum="CE9CC1F97AB631BC" modified="2014-04-16" version="1">MASSRSSRRARPQWPPAPSVEEEPQSLSKELNGLSKLGDKPGFDGVHIRGAVDQYPIIVAANSPPPSSTSPVSVPGVSGLGSVSSDESAGPKTPPPQEPIFRNTVRFETNDRPKYVSPSTASQPRGPAPQPLAQQQPIRELNPPRVPQPPSHIRDSNFSRHGPPMQNTSHGSRGPSAPDRSDARAPMQDKTCLQPPGPSIGRSNSARYTHSTRPMPERLRREPSSGYLSDSATTDNRPPHRPQPPVSTAPVSALPNGPTLAERIEEKLRQRQEQRDPGFVSDPEVRQIPTTVKPVKPHILNTSLPPPPPIPAPASHSPLRGPQRVPAQRSQHELLPASRARATSVTMPPTRSMSGSRHPSRPAPEMTKPISTPLNPDRSLAHLAPTRPAATSPQRPSSVGLGLSPCPRTIAVAGYQDWYTLKGLTHLDICPSCVSQLSQSRYRDYFIPSLSKPAGQKTRCAFANAWTRLAWAQMIKKQHDSLELLYQMTRPPPGMRVCPGRIVAEQSWHRIYDPETGTDLAGFHVCNSCARNIRILMPSHRETFLPSRDPSERLCDFVTSSPRFVKFIDLLDASASRAEADSSRTRRPDMREFLNYARRKVVLRDCRRDRPALSTWHFIPSLPEMCVCEDCYDEVVWPLARSNHPIACMVTTKMRILPGDGPGRTREASCQLYSPRMRAKFREAVVTDDFGLLRSVAQRRVEAERRFLDRREELLVAQAKGYDCDEEMRKAVDEWRRWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q4J8</accession>
    <name>W6Q4J8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S01g002915</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q4J8"/>
    <dbReference type="OrthoDB" id="10271171at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM29104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="61" mass="6843" checksum="21D70EA38F37C611" modified="2014-04-16" version="1">MPASLISTQNPSKKKVAKDSWPIYIAQTVFRHPDNSLALLFRSLYIGNPSKSIHQFDLITG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q4N6</accession>
    <name>W6Q4N6_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PROQFM164_S02g001081</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q4N6"/>
    <dbReference type="STRING" id="1365484.W6Q4N6"/>
    <dbReference type="OMA" id="ANKAHKG"/>
    <dbReference type="OrthoDB" id="4205486at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029208">
        <property type="entry name" value="COX14"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14880">
        <property type="entry name" value="COX14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM30931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="269" mass="28946" checksum="76A04E668CE19486" modified="2014-04-16" version="1">MSRSAADATRFTATGPYAHSKTGGANQASDFGKKKSSVKSSPKQLGPNGQPETPKEKVERLRAQARAARKTQAAGSSADRWIESGRKFANKAHKGMVYSLIAASGVCGVLTVYSMISLTLYNRRQRTLWIEKELKTLKDAEIAYANGTATTEQQELLKKEKIGEIMKQKREEEKAQKPWAKAKRFLFEKLNMEDSGANPAPTSASALAIEGADKGQGSVMEAVQAKQALDSAAAKTGAPLPGQLDVLAENVGQAAKSKTSSWTSWLTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q4P9</accession>
    <name>W6Q4P9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S02g001455</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q4P9"/>
    <dbReference type="STRING" id="1365484.W6Q4P9"/>
    <dbReference type="OrthoDB" id="2823490at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM31305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="237" mass="27807" checksum="F03059F18813CB2F" modified="2014-04-16" version="1">MKETTYILDLSVLNEMYMFSTWISVPRLTTRLSTLHIDMRFFGRIVTSKDALCSESATFSLNHCFYRYLDRFLTYGPVGRKDDRGIIAETLVLDFHSAETELSFPPGHMSYEDWEANRCGNPRWDDEQMDEVLKYKTRPQWPLSAMRLWLAFITKVGYGVEDYGSLYESIGTITLLLNGRLETAFDLADQLAEVPNEMYDRYPNFNVPKFQKWRERTLSRREAVGLCTVQPRDLWSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q4Y1</accession>
    <name>W6Q4Y1_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S02g001869</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q4Y1"/>
    <dbReference type="OMA" id="EFKVICM"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF110">
        <property type="entry name" value="RHODANESE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase" evidence="1">
        <location>
            <begin position="54"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM31718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="292" mass="32847" checksum="240EB8CD1F4CBB56" modified="2014-04-16" version="1">MAEKVDMNTFFKSEEYASSFRRAEMVTRPFAETLVEQSKVAAESRANPDQPLVVLDNACGTGVISSTLNGKLDDTVKKMWKLTCGDISSAMIEYTMHRMQEEGWQNTETKIVDAQNPELPSGQFSHIFTAFAYMTLPESLKALNETVGMLKPGGTIAFSTWIQPGWIPIARQVIESMPGNLPFPEAPKLLGVITDGQWHSKPWIESQLEGRGLQDIDVREITTKLTLTSPILVEMIMMMLPVLMKSFWTEKQREENTDNVRPAVEKYLEDTYGHGNIDTDWMAILSTARKSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q526</accession>
    <name>W6Q526_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Vacuolar calcium ion transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PROQFM164_S02g001236</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Has a role in promoting intracellular calcium ion sequestration via the exchange of calcium ions for hydrogen ions across the vacuolar membrane. Involved also in manganese ion homeostasis via its uptake into the vacuole.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Vacuole membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q526"/>
    <dbReference type="STRING" id="1365484.W6Q526"/>
    <dbReference type="OMA" id="WHVSRAF"/>
    <dbReference type="OrthoDB" id="1699231at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015369">
        <property type="term" value="F:calcium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004713">
        <property type="entry name" value="CaH_exchang"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004798">
        <property type="entry name" value="CAX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00846">
        <property type="entry name" value="caca2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00378">
        <property type="entry name" value="cax"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503">
        <property type="entry name" value="VACUOLAR CALCIUM ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503:SF22">
        <property type="entry name" value="VACUOLAR CALCIUM ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0050">Antiport</keyword>
    <keyword evidence="6 10" id="KW-0106">Calcium</keyword>
    <keyword evidence="4 10" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="8 10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <keyword evidence="10" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="108"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="170"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="236"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="280"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="319"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="352"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="383"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="411"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="11">
        <location>
            <begin position="107"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="11">
        <location>
            <begin position="288"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDM31086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="440" mass="47274" checksum="AB5D7D21A18CF1F5" modified="2014-04-16" version="1">MNNTAHPRLRKSTKIDPEIMAGPLEANATAHEQDALLRDETECESHGEESAELRDTNHPVSKCALFLGNSLFRVLKATLGCSYTNLLLPFVFLGIIAGGQGWGDSISFVFNFLAILPLAALLSFATEELAKSVGQTVGGLINATFGNAVEMIVGITAVRQGEISIVQSSMVGSILSGNLLILGVSFFCGGYAKDVVRFNVDVSGILSSLMVVSSATLIIPSVLYSTIPSKSHEVEVSVLSLSRAASVVLLTFYLVYLYFQLKSHAELFVDDQKEEEEERVLGPWSASIILILATLGVTVCSDRLVDSVDGFVDKWHVSRAFIGLIVVPIVGNAGEFNTVVNSSIKGNMDLAIGVIVGSTLQIALFVSPFLVICGLVIGQPMSLRYSPFETVVFFLSVIVMDCLIRGGRSNYYEGSLLVGTYLIIAIAFYVHPDAVDAPFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q5N6</accession>
    <name>W6Q5N6_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S01g003361</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q5N6"/>
    <dbReference type="OrthoDB" id="10266325at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM29549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="64" mass="7149" checksum="0A6F53005F434EB6" modified="2014-04-16" version="1">MSQNDYYLEGVDSSKAAAEAHYLCIPKGEQRPCQKKNSWHVAKPQQNSVISILVAFSIQTLGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q654</accession>
    <name>W6Q654_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S02g001926</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q654"/>
    <dbReference type="STRING" id="1365484.W6Q654"/>
    <dbReference type="OrthoDB" id="3535423at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM31775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="94" mass="10469" checksum="3280DD8B35846570" modified="2014-04-16" version="1">MVLKFPTENEGVEVCIARPGVIANPSTWSRALVANLFRIVGFFGRSLPNIQRSELAAAVLNQVMDGFEKEALLNADLVRIGQRELKFSSMPYRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q6Q2</accession>
    <name>W6Q6Q2_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP-dependent DNA helicase CHL1</fullName>
            <ecNumber evidence="18">5.6.2.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">ATP-dependent DNA helicase chl1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Chromosome loss protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19 20">DNA 5'-3' helicase CHL1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">PROQFM164_S02g002534</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="21">ATP-dependent DNA helicase important for chromosome transmission and normal cell cycle progression in G(2)/M. May have a role in changing DNA topology to allow the loading of proteins involved in maintaining sister chromatid cohesion in the vicinity of the centromeres. Has a specific role in chromosome segregation during meiosis II.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DEAD box helicase family. DEAH subfamily. DDX11/CHL1 sub-subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="18"/>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="W6Q6Q2"/>
    <dbReference type="STRING" id="1365484.W6Q6Q2"/>
    <dbReference type="OMA" id="LCECEAS"/>
    <dbReference type="OrthoDB" id="267079at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034085">
        <property type="term" value="P:establishment of sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="ATP-dependent DNA helicase chl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045028">
        <property type="entry name" value="DinG/Rad3-like"/>
    </dbReference>
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        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
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        <property type="entry name" value="Helic_SF1/SF2_ATP-bd_DinG/Rad3"/>
    </dbReference>
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        <property type="entry name" value="Helicase-like_DEXD_c2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010614">
        <property type="entry name" value="RAD3-like_helicase_DEAD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472:SF41">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE DDX11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472">
        <property type="entry name" value="DNA REPAIR DEAD HELICASE RAD3/XP-D SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06733">
        <property type="entry name" value="DEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00488">
        <property type="entry name" value="DEXDc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51193">
        <property type="entry name" value="HELICASE_ATP_BIND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="16" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 25" id="KW-0347">Helicase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="14" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="24">
        <location>
            <begin position="1"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="105"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="23">
        <location>
            <begin position="105"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="23">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00029709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00044969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00044998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00045008"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00045702"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00048954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="CDM32383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="422" mass="47764" checksum="7E0BBB7B748BB26D" modified="2014-04-16" version="1">MDFHHPYKPYDIQLQFMQALYACLEDSKVAVFESPTGTGKSLSLICGSLTWLRDHKRKAFQESVDATCDDDEPEWMIEHAKRESRRAITEKRQELEARLAKIRQEEGRLKQAQDSADRPRKKQRLDDSAPELVDDDDQFVLDDYDSDTDNQKRQNDSGNSDGLSASTLALLERFQGKFSTQKKEKEDDGDDEIKIFFCSRTHSQLSQFAGELRRVTFPSSLPSDLDPESKDDLSKLEERVKHLSLGSRKNLCINPKVRALENNTAINEKCLDLQQAGVAADKKCPFIPSKDDEALALEFRDHALATVKDIEDIAQVGKKLGICPYYASRPVIKHSEIVTLPYPLLLQRSAREALNLSVKGHIVIIDEAHNLMDAIAGIHSVAVSLSQLQTAIGQLTTYARKFKNRLKGKNRNYVAQVIRLDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q6U1</accession>
    <name>W6Q6U1_PENRF</name>
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        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">PROQFM164_S02g002221</name>
    </gene>
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        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM32070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="63" mass="7109" checksum="8B4B2B3D6F9D6042" modified="2014-04-16" version="1">MPRTLVTEIAGESEESQSLREQPNKKVWILTKGSDTCRRFVGIRGLGKGKGLTLGCYVHWPRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q7D7</accession>
    <name>W6Q7D7_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S02g002401</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="DUF4220 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35043">
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="19"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="294"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="325"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM32250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="445" mass="51381" checksum="FFC221B8349129C5" modified="2014-04-16" version="1">MNGTIINDWVDEPDGRGTWGILSTCVLTIILCCWTSVSPNLPAQTDGAFTRWRYKFDLACIALLGSEFLLLLVLGQWSSARRSIRDFHDAGYKNWTIKHAFFADMGGFLIEPPEIDCLPSFPLNGKQLFILVKGGYVDYPSIKKEEIEDKSKSDRLARLITIAQALWFCLNCVFRFAQGLHVTTIELTTLSFILNFLVTSYCWYHKPMDIERPVTLKLKSSVAIIRKKLDQNPESKWYETPLDFISRNEWFYSRFWRYYIQISHSMRIPLFTRPTRRPYDRIPSHFIPVVDTQAEIICGPVILLFSSIFLIAWNYHFPTETERLLWRIASVDALAYALVGGLLALYFHRTIFQPDLPYTTAQASFEQKGERHGWIGRIAARLRNIDPEQDPNLEIPIRALVPISFLCAIYAIGRGFILTEDLIGLRSLPESAFETVSWSKYVPHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q7E3</accession>
    <name>W6Q7E3_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S02g002411</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q7E3"/>
    <dbReference type="OMA" id="NDGWVLK"/>
    <dbReference type="OrthoDB" id="4177946at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="225"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM32260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="381" mass="40774" checksum="3CB7E07F841391C4" modified="2014-04-16" version="1">METTNYLSLPAIAEFINAYEANPTAENVKIMVSALLTYAFDSNDGWVLKWQEDEENNHSNCFVVKASGDERSLHTIVKVVLDTSVSVQADWDQFVPRLLSAPLPDERCWAILIRGYKVRLYEYHRDQELPYRLIPCDFKVKDKLKHTVHIHKNPDAVNNILMSIPNQVPKPLGEGEQANPSPPVSVAETTGSEASPNATPETVRASGVDIESSSEDLTDTSGIKTPTEAEPVTEPEAIPQTKTATQVDSTTSQTKHTTANGTKAKVTPQAKVIPQAKATPPVKITPEVKAALLAKAAAKAKSATPVKPAAGVKTATPSKTASQVKSAAEFKSAAQAKNAAQVKSAAQAKAAILAKAVSGMKITPKVKPAKEIEVVAQTATN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q7K7</accession>
    <name>W6Q7K7_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S02g002132</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q7K7"/>
    <dbReference type="STRING" id="1365484.W6Q7K7"/>
    <dbReference type="OrthoDB" id="4295657at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM31981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="106" mass="11760" checksum="633AA86BB480B2B6" modified="2014-04-16" version="1">MQYSSRQVVLMPQGGYLVTKDFTTAKSLNAIASFIIYGLDETLPTEAREVCFDWMERCLDVTFAQQQVTTALSAWLKAETKLTVWASALEDGELTLDACANVTART</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q8K7</accession>
    <name>W6Q8K7_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S02g002442</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q8K7"/>
    <dbReference type="OMA" id="AYFNITR"/>
    <dbReference type="OrthoDB" id="5390143at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004879431" description="Mid2 domain-containing protein" evidence="3">
        <location>
            <begin position="22"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="170"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM32291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="258" mass="28535" checksum="194C291246DB503B" modified="2014-04-16" version="1">MIRLFQPLLILLSALLATVKAEKTNYMINPVYINGKSPVWTLGDQKVVAWKTDLPVFNVSIWQQSPLGGGAYTRGNVYAQVHEKDHVSNFTWTVQLYGFDLDYSPTFFFWINPGPGGFPSAYFNITERSSTAKTTPSIPVNSTLASSFPSSDTTVSPTDQPPALTTTAKLALGLGVGIGVPILVAMATLVWLRVRRLRATRQAAASMAVPRGTEMQQRQPHMHVREIRGTDPTEFCQELPQDTAGKPLRPELPDQRYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2024-10-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q9I6</accession>
    <name>W6Q9I6_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S02g002832</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q9I6"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM32681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="190" mass="21551" checksum="2B28A23CFEE33BF3" modified="2014-04-16" version="1">MAHELGFRDRHPLARLQRYYHSHETLEKNSTRRANQTPRANLDRRSSNFSAISVRWNGGLLPRYCWGSRILPHPLTEGVFLWLIELYFPGFGDRSTIPAIICVGAGFPRQRPMSVQLGEKTILGVSSRQNLASYKWALQTLIATSGLENDLFILACATSLVTSGWENSLSHLNTDLTIGRIRKIPFTDQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q9Y4</accession>
    <name>W6Q9Y4_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA N(3)-methylcytidine methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PROQFM164_S03g000192</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">S-adenosyl-L-methionine-dependent methyltransferase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the methyltransferase superfamily. METL family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="4"/>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q9Y4"/>
    <dbReference type="STRING" id="1365484.W6Q9Y4"/>
    <dbReference type="OMA" id="PAKYWDI"/>
    <dbReference type="OrthoDB" id="417697at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052735">
        <property type="term" value="F:tRNA (cytidine-3-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026113">
        <property type="entry name" value="METTL2/6/8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22809">
        <property type="entry name" value="METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22809:SF11">
        <property type="entry name" value="TRNA N(3)-METHYLCYTIDINE METHYLTRANSFERASE METTL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037755">
        <property type="entry name" value="Mettl2_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 12" evidence="6">
        <location>
            <begin position="136"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="300"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR037755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM33468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="388" mass="44582" checksum="14FE09E573AB1E7E" modified="2014-04-16" version="1">MTVDPSIQEVTQNVEPPQVDPHRSHDPSNNLKRTDPFQFGSRYLEKGDDVFEFNAWDHVEPDDEFKAFAETQYARQRETRVSDFDRNRFNQDPAKWWDLFYKNNTANFFKDRKWLRQEFPILADVTQKDAGHQVVLEVGAGAGNTAFPLLANNENEHLRVHACDYSKYAVKVMRESELYNEKYMSADVWDATAVPDENGDSLPPGLTEGSVDVVILIFIFSALAPNQWDQAIRNIYRLLKPGGRVLFRDYGRGDLAQVRFKKGRYMAENFYIRGDGTRVYFFDKDQLIDMWSTWSAESGLQIPIGDENPTEEASEEKKDPQPAEELSAEAKQLAKDSGAFEVLNMGADRRLIVNRGTKQKMYRCWMQGNFRKRGGAESEAKAVTENTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W6QA77</accession>
    <name>W6QA77_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S02g003062</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QA77"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM32911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="112" mass="12463" checksum="CA44BB538CFBF7C9" modified="2014-04-16" version="1">MSRNDAAGRRKREHDGEFKRLASAPGMALHASKPPEMQSAGCCSKLGIESYVSIRNSNSWSTTSKAFPVRKKPSLEQESPSLYVTFPNYQTLPQRKKFPRGFPTESGAEVFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W6QAD9</accession>
    <name>W6QAD9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S03</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S03g000074</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QAD9"/>
    <dbReference type="STRING" id="1365484.W6QAD9"/>
    <dbReference type="OMA" id="PINRPEG"/>
    <dbReference type="OrthoDB" id="418495at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="56"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="263"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="337"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="402"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM33350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="524" mass="57107" checksum="4FE8F26A2F0AE510" modified="2014-04-16" version="1">MAGVATAAYSADALASPVDGSLWDFAVPLVHEDNHHSSKQRESHDSNSIGAKFSRQRTSNGSRSSSVSRNVHAHESPYLASNRGRREPSLNRHGSEVGSMRDAFGSEAAGRKEPEEADDDLQLSLDGKTNQEKWIHRDKLAKIESEELHQAAILFQRRMRGESKSSVGRGRSYDSHQSPANGTGTATSPAAEYSEPWPKVKEEPGKRGVNNNVGGSVREHWDLRRPEEIAADDAAASLYSHPGLGKSASRIPISTASPVPILGRDSGSSRSRAATDEEDRSSRNRRASEPITIEQDGSTPSPQSRPGSRGFSSTQNTGKKTVKSSTNRKTSAPPANRKTSTPRSRAVSGNNTQRPTTRSGESRLPTTANRPEGDPPWLATMYKPDPRLPPDQQMIPTVAKKMMQERWEKEGRTPNTYDRHFAPLAVHPFDTPPPVATKAEPEPQPQPQPQPVESLQLEDLSPRPSKSPEPPRPNTSTGYSTMPKVQETPPMGLAPNPNPNWSPPVVTAQQLPKKEKSCGCCIVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W6QAN8</accession>
    <name>W6QAN8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pyruvate/Phosphoenolpyruvate kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S03g000239</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = pyruvate + succinate</text>
            <dbReference type="Rhea" id="RHEA:16809"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57429"/>
            <dbReference type="EC" id="4.1.3.30"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the isocitrate lyase/PEP mutase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QAN8"/>
    <dbReference type="STRING" id="1365484.W6QAN8"/>
    <dbReference type="OMA" id="DRIGYHA"/>
    <dbReference type="OrthoDB" id="1923844at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046421">
        <property type="term" value="F:methylisocitrate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00377">
        <property type="entry name" value="ICL_PEPM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.60:FF:000009">
        <property type="entry name" value="2-methylisocitrate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039556">
        <property type="entry name" value="ICL/PEPM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018523">
        <property type="entry name" value="Isocitrate_lyase_ph_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42905">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42905:SF15">
        <property type="entry name" value="PHOSPHONOMUTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G03820)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13714">
        <property type="entry name" value="PEP_mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00161">
        <property type="entry name" value="ISOCITRATE_LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00061405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM33515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="305" mass="32352" checksum="26659C573D861188" modified="2014-04-16" version="1">MALPSAATSLRRSLQDPQVFITAPGVYDGMSARLALAAGFDALYMTGAGTAASVHGQADLGICTLNDMRANAEMLANLSPRTPLIADADTGYGGPIMVARTTEQYARSGVAAFHIEDQVQTKRCGHLSGKQIVDTKTYISRIRAAVQARERIGSDIVIIARTDSLQQHGYEESLARLRAARDAGADVGFLEGISSREMARQVVADLAPWPLLLNMVEHGSTPSISAKEAKEIGFRIIIFPLATLGPALVAMREALEKLKSDGLPGLDKELTPQMLFRVCGLDDSLELDAAAGGVAFEGGVDIGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W6QAZ4</accession>
    <name>W6QAZ4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Armadillo-type fold</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S02g001449</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QAZ4"/>
    <dbReference type="STRING" id="1365484.W6QAZ4"/>
    <dbReference type="OMA" id="MAIIQND"/>
    <dbReference type="OrthoDB" id="6260732at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010265">
        <property type="term" value="P:SCF complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039852">
        <property type="entry name" value="CAND1/CAND2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12696">
        <property type="entry name" value="TIP120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM31299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="303" mass="32429" checksum="D271699ED93EEE12" modified="2014-04-16" version="1">MADRQVTQQTIFALLAKLDDPDADLRYMSLNDLYGILTNPNSLFLSHDRGTATKLAGGLLKALDDQHGDVQNQALKCLGPLAVRLPLESLTPLLEQLANLTASQTIDTSVPNTALRVIVDTLPRPQSGQPPSQNSIIAYTAVSEVLVPRLTGPTLSITGRRSSVVRGMMEKDPSRGFSSDAIDVLIKVVTCFGPLLQDSELASLQASVMAIIQNDTAGTVVTKRALTAISALVLYFSDNQLNEFVSDLTKTLSSEISVVQRRHLIAAIGAIAKTAPGKFGPHLDTLVPFVFSAVGEDNITRAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W6QB76</accession>
    <name>W6QB76_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Taurine catabolism dioxygenase TauD/TfdA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PROQFM164_S02g001544</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TfdA dioxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QB76"/>
    <dbReference type="STRING" id="1365484.W6QB76"/>
    <dbReference type="OMA" id="SSHMQNY"/>
    <dbReference type="OrthoDB" id="10257314at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.130.10:FF:000003">
        <property type="entry name" value="Alpha-ketoglutarate-dependent taurine dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051323">
        <property type="entry name" value="AtsK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT SULFONATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468:SF31">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT SULFONATE DIOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="8">
        <location>
            <begin position="93"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="365"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="365"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM31394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="399" mass="44464" checksum="1166C6502C5A3F03" modified="2014-04-16" version="1">MAPSLEEPVVTVAPTVAKFTVPVLARDAGDNKFGYQPGQTPVTRHDNYAHEDLLPSFPDLHWAPLEYTPYEDKGLRGDAKFRNLLRDATAVFDYNPKVGTEIHGVDLSKLDDAQRDDLARLIAYRGVVFFRSQKNFDIEAQRQLGEYWGKLHKHATTSVPRKAGLEDVHVVYAGDNAPDNRALFTPSFLWHSDVTYEIQPPSYTSLKLLSGPPRGGGGDTLWSSQYAAYDLLSSHMQNYLKGLTALHSADMQANDSRALGRPVRREPVTTEHPLIRTNPVTGWNSLFFNPGFVKKIVGIPTAESDAIIRFLTDVIATTQEMHARFSWGQDDVALWDNRSTNHSASYGFTPHRRHAVRVAVHAEKPVLEETGKSQEDESNALSGLPAVNKDGSRQSNYND</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>W6QBB0</accession>
    <name>W6QBB0_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Zn(2)-C6 fungal-type DNA-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PROQFM164_S03g000712</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QBB0"/>
    <dbReference type="STRING" id="1365484.W6QBB0"/>
    <dbReference type="OMA" id="PMRTHKS"/>
    <dbReference type="OrthoDB" id="4898680at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF61">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="21"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="74"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="10"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="74"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM33988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="681" mass="76969" checksum="1B1B9D06CBD0472D" modified="2014-04-16" version="1">MRNDDRRSASPATRKNGTLQSCEPCRRSKQRCDHDRPVCRRCTAKRISDKCFYHPAPMTRRRPSDSVNPAIVSSRLTSQPTSNASSPGSGSLGNGRFFTPLEPPAALPGYLGSTSYSAVLTEHRSEISFEPEESTDSSAGLIVEPDRLQSGVDVLRFLYNLTVCDMLIARFYGRTWNNTVVPKIVIDELLRSVRDIFDGFSSDPTAQLQDLANQIFQNTSRPMRTHKSMSVEEYCSSFTGRNLRWEALGSIFALCGMQLAITPDNDPDITRGSDEPRAKDRLLEQVTVISTVCLGFCDQTSSANELLAMLQFNDAMLRTQQYGDSSYQAWRRLGDLVSTIYAAGLHLETNCIENCPFFLRQWRRRCFVASFCMDKMIATFVGRPPLMNGRFCTLDAPLDLSDEVLVAGGDVLSNAISELNSAGWNSQGRLHLVTPTRLRYQLAIIREETLEVVLGTREQHDLIQKSEEIQEKSRAIWQSSPDQLRYDRRSNDHFHDGWLTIVYFYLDYLYTSFLLYRAVVKNTNTGQADLCDVSRRVLAIVIQINSFRTPMVDLDRHFSWIVLTYGVPSASVLLLELLRQSHESGPHAVPLPRAELIRNLSVFISFLSWVAGPGHGNYHTCKQAEKKLSRILDQLLDPEPVQQHVVDDVTTGLDNFLNWSNYNTIWDFNPDYMPLTEGLAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W6QBD8</accession>
    <name>W6QBD8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g000816</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QBD8"/>
    <dbReference type="OMA" id="VAPRCFQ"/>
    <dbReference type="OrthoDB" id="5366332at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="262"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM27007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="336" mass="37474" checksum="B3FE43E827027109" modified="2014-04-16" version="1">MTSVTCLALQPSLSISKCESTVTELKGCDSPKSPSEMAKVKRIDPPGNELGRQESRASTSTSISHSRSASRSTVRSRPNSRRSSLHSRRAVPNAAIVPVTSARSSMQDKRESLIALHRESCRLFQDESNRPSTETRLSLYRTASATYRPQRESRISTEKGSSEPSSPVRHSYSSIRFGIESTSPTSTSAPHFITPRDRSNTLPSSHHRSPSSSSIHVPATVMEWTSPDTRRREYEKIDRASSGVRGLWRRVAPRCFQSRDSRTPFFEEGKTEREGSVRRFRMDIPEDEEPESDSQGNPQAQLLELLGKTSLNSNSPDGARRRWTCLRSKSSPLPNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W6QBI6</accession>
    <name>W6QBI6_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Meiotically up-regulated gene 14 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">mug14</name>
        <name evidence="2" type="ORF">PROQFM164_S03g000797</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QBI6"/>
    <dbReference type="STRING" id="1365484.W6QBI6"/>
    <dbReference type="OMA" id="REAHDWT"/>
    <dbReference type="OrthoDB" id="3238794at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.225.10:FF:000009">
        <property type="entry name" value="Class II aldolase/adducin N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="entry name" value="Class II aldolase/adducin N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051017">
        <property type="entry name" value="Aldolase-II_Adducin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004855">
        <property type="entry name" value="PRK06208.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10672">
        <property type="entry name" value="ADDUCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10672:SF40">
        <property type="entry name" value="CLASS II ALDOLASE_ADDUCIN DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_3G09800)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="AraD/HMP-PK domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Class II aldolase/adducin N-terminal" evidence="1">
        <location>
            <begin position="66"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM34073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="303" mass="33062" checksum="B6DBB3D20D3C5620" modified="2014-04-16" version="1">MSTSTTITQQVQSVRLTNEDQLPPLPPAANDASFQGLARGGRNGTLKLRGIPTFSDLTEKRKWMKEHMAAAFRYFGKLGYGEGVSGHISMRDPILKDHFWMNPFAKHFSTIKASDLVLLDADGFVVDGGAQLPVNEAGFLIHSEIHKARPDVVAAAHTHGIHGKTWSSFGKPIEMLTQDACNFFGRVGVYEDHGGIVLSAEEGKAIARALGKENIACILQNHGLLTVGRTVDEAAILYSMLENACQSQLLAEAAAANGLPKKIIKDEAAKFTADAAQNPHNFYTEFQPEYDLLIEETNGRFLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W6QBM9</accession>
    <name>W6QBM9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Isochorismatase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S01g000871</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the isochorismatase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QBM9"/>
    <dbReference type="OMA" id="IPYDWPH"/>
    <dbReference type="OrthoDB" id="167809at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00431">
        <property type="entry name" value="cysteine_hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="entry name" value="Isochorismatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050272">
        <property type="entry name" value="Isochorismatase-like_hydrls"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43540:SF9">
        <property type="entry name" value="FAMILY HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G08700)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43540">
        <property type="entry name" value="PEROXYUREIDOACRYLATE/UREIDOACRYLATE AMIDOHYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="Isochorismatase-like hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase-like" evidence="3">
        <location>
            <begin position="168"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM27062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="389" mass="42659" checksum="52F81CDD38BFF8F0" modified="2014-04-16" version="1">MADSTDLNLDDAPSDLQDIPELAMQLVPPPEGTYPDKASLLAAVQDHGKEHGYNVVVKSSSTPTEKKPGRTAKVWLRCDRGGHYRPRNGLTEETRKRRRTSRLMDCPFMLVAAGSPGIWTLTVLNATHNHGPIIEKPRQVPHHKVRKGQLPATPYDWPHDASFTPYTTALVIIDMQKDFCLPEGYMGYQGYDISSAQALIPPLQRLLHAFRSGGFPVYHTREGHRPDLSTLSSREAYRSRNNASGLGIGSPGPMGRLLIRGELGHDTVDELYPLPGEPVIDKPGRGAFAHTDFELLLRNKGVKNLVIAGVTTDVCVSTTMREANDRGFDCVVLDDGTAAAEPSLHLSTIQSIKMEGGIFGTVAKLEDVIHAVDNFKTVTMKKLAPQMTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W6QBP2</accession>
    <name>W6QBP2_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S02g001724</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QBP2"/>
    <dbReference type="OMA" id="HFEVKFL"/>
    <dbReference type="OrthoDB" id="4265181at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="11"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM31574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="229" mass="25421" checksum="3C875EC00054C75E" modified="2014-04-16" version="1">MPSLPQRYQALQSTMANNNDQSSATGALSRQVARQIRQARGHSTGRPDATNAHQATSFRNPIRPGMASSRFATFTSEDQSEPAPDPMDIDPMEIGSPPPQQAQPAPTTTLTRINEQAQNSGMHRQKFYLSIGPRPMPTLDLDVLTVARAEVTRLQRAGLPVLESLPERAGPHLYIRIDTGQASRDQALARADLRMGIMQDMIRDGFGWFSGLPYRHPHFEVKFLRGPRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W6QC14</accession>
    <name>W6QC14_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cytochrome c oxidase subunit 4, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Cytochrome c oxidase polypeptide IV</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">cox-4</name>
        <name evidence="14" type="ORF">PROQFM164_S03g000330</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FM164</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome c oxidase subunit 5B family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QC14"/>
    <dbReference type="STRING" id="1365484.W6QC14"/>
    <dbReference type="OMA" id="DHKPYWM"/>
    <dbReference type="OrthoDB" id="10249250at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045277">
        <property type="term" value="C:respiratory chain complex IV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00924">
        <property type="entry name" value="Cyt_c_Oxidase_Vb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.11.10:FF:000003">
        <property type="entry name" value="Cytochrome c oxidase subunit IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.11.10">
        <property type="entry name" value="Cytochrome c oxidase, subunit Vb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002124">
        <property type="entry name" value="Cyt_c_oxidase_su5b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036972">
        <property type="entry name" value="Cyt_c_oxidase_su5b_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10122:SF0">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 5B, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10122">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 5B, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01215">
        <property type="entry name" value="COX5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57802">
        <property type="entry name" value="Rubredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51359">
        <property type="entry name" value="COX5B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="6 12" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00070613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR602124-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDM33606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="196" mass="22142" checksum="F6845D914BEF7F66" modified="2014-04-16" version="1">MFLQRTASALARRSPARAFTLAQRPFSSSVIRSSDKKWAPKQEGKILTFDEIKTEDDLFAPGAKPGTIPTDLEQATGLERLELIGKMQGIDIFDMRPLDASRKGTIEDPIIVNSAGDEQYAGCTGYPVDSHQVNWLTVSRDRPIERCRECGNVVKMNYVGPEEDPHSHDDHGHHHHPAHVEPKTFADYVKPDYWYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>W6QD13</accession>
    <name>W6QD13_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable E3 ubiquitin ligase complex SCF subunit sconB</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Sulfur controller B</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Sulfur metabolite repression control protein B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">sconB</name>
        <name evidence="16" type="ORF">PROQFM164_S03g001074</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the SCF(sconB) E3 ubiquitin ligase complex involved in the regulation of sulfur metabolite repression, probably by mediating the inactivation or degradation of the metR transcription factor.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the SCF(sconB) E3 ubiquitin ligase complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat MET30/SCONB/SCON-2 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QD13"/>
    <dbReference type="STRING" id="1365484.W6QD13"/>
    <dbReference type="OMA" id="GIAHVWS"/>
    <dbReference type="OrthoDB" id="5580488at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990756">
        <property type="term" value="F:ubiquitin-like ligase-substrate adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd22147">
        <property type="entry name" value="F-box_SpPof1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.50:FF:000016">
        <property type="entry name" value="E3 ubiquitin ligase complex SCF subunit sconB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000715">
        <property type="entry name" value="F-box protein MET30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051075">
        <property type="entry name" value="SCF_subunit_WD-repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19872">
        <property type="entry name" value="UBIQUITIN LIGASE SPECIFICITY FACTOR/HREP PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19872:SF9">
        <property type="entry name" value="UBIQUITIN-BINDING SDF UBIQUITIN LIGASE COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0436">Ligase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="9" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="6 13" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="F-box" evidence="15">
        <location>
            <begin position="165"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="13">
        <location>
            <begin position="339"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="13">
        <location>
            <begin position="379"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="13">
        <location>
            <begin position="419"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="13">
        <location>
            <begin position="457"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="13">
        <location>
            <begin position="575"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="13">
        <location>
            <begin position="600"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="13">
        <location>
            <begin position="640"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="24"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CDM34350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="677" mass="76023" checksum="8860DF508DF6AF03" modified="2014-04-16" version="1">MADKPESSSTQQSLVIANAGVSANADSNRSPPGKNTDNTTQTLDELGRQNVAPFLEKYQPRQYAPLRSQVSAPSEHHVVNASYCYRHQPDSKCGRRQADEQSMTQLQSELNLLPQCDQRGISHVWSLFSAAPAKQRTLMLQGILAQSCFPQLSYISASVRELIRIDFLGALPPELSFKILRYLDTASLCRAAQVSSRWRALADDDVVWHRMCEQHIRRKCNKCGWGLPLLDRKRLREAKREIELRATNWGNNEPAAGSTEAAMVESCSTVEEPRVSGKRKMESDEVSVLAKRHCASLPQSPEEDDNYFKTRYRPWKEVYRDRFVVGMNWKHKRCSVKVFKGHRDSVMCLQFEDNILMTGSYDATVKIWDTDTGEELRTLKGHVAGVRCLQFDDTKLITGSLDRSIRIWNWRTGECISKYNGHAEAVIALHFDCTLLASASVDRTVKIWNFKDKSTFVLPHPQGVNAVKIDSASRTVLTACDDGAARLWDLDTKTCIRVFHNHIGAVQQVLALPREIELENHLADCENDHVSTSSQNGDNILSTLSPLLEAKSLSLPNSPFGSSFDQDQGRVEPPRYIITSGVDTTIRLWETSTGRCLRTFFGHLEGIWALSADTLRIASGGMDRMVKIWDPRVPTGQDTYEGHSAAVNCIGLSDSRFITGGDDYQVRMYDFRASSGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W6QD52</accession>
    <name>W6QD52_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Histidine phosphatase superfamily, clade-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S02g002270</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QD52"/>
    <dbReference type="OMA" id="NWVDARL"/>
    <dbReference type="OrthoDB" id="496981at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050275">
        <property type="entry name" value="PGM_Phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100">
        <property type="entry name" value="BROAD-SPECIFICITY PHOSPHATASE YOR283W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100:SF1">
        <property type="entry name" value="HISTIDINE PHOSPHATASE FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM32119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="300" mass="34191" checksum="702565570FCCCF39" modified="2014-04-16" version="1">MHSPPLFRFTTVTGYFLQDDPATDPDTFDYVNSNFGLIEKQYDEHLGVEQTDSQWQRFDAHIKRQNASKSKKLKVLFLGRHGEGVHNVAERKYGSKKWNEYWSLQDGDEDGSWVDARLTEQGRCQAKVAHAAWEQQIKTGIPSPESYYVSPLNRCLETAQITFQGLAIPGTDPFKPTIKELLRETMGQHTCDRRSTASEIADEYPEYRFEAGFSEEDKLWDREVRESDEHRTERLRGLLNDIFAHDESTYISLTAHSGAITSILEVLGHRRFALATGAVIPVLVLVERGVPSQLESQELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>W6QDL2</accession>
    <name>W6QDL2_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 12">Vacuolar protein sorting-associated protein 27</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">vps27</name>
        <name evidence="17" type="ORF">PROQFM164_S03g001304</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 12">Component of the ESCRT-0 complex which is the sorting receptor for ubiquitinated cargo proteins at the multivesicular body (MVB) and recruits ESCRT-I to the MVB outer membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 12">Component of the ESCRT-0 complex composed of HSE1 and VPS27.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 12">Endosome membrane</location>
            <topology evidence="2 12">Peripheral membrane protein</topology>
            <orientation evidence="2 12">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the VPS27 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QDL2"/>
    <dbReference type="STRING" id="1365484.W6QDL2"/>
    <dbReference type="OMA" id="HTWGGNT"/>
    <dbReference type="OrthoDB" id="957735at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033565">
        <property type="term" value="C:ESCRT-0 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15735">
        <property type="entry name" value="FYVE_spVPS27p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21385">
        <property type="entry name" value="GAT_Vps27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16979">
        <property type="entry name" value="VHS_Vps27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.1940:FF:000001">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000031">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000161">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017073">
        <property type="entry name" value="HGS/VPS27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002014">
        <property type="entry name" value="VHS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049425">
        <property type="entry name" value="Vps27_GAT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47794">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47794:SF1">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02809">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00790">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21356">
        <property type="entry name" value="Vps27_GAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036956">
        <property type="entry name" value="Hrs_Vps27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00726">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00288">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50179">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0967">Endosome</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="VHS" evidence="16">
        <location>
            <begin position="24"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="FYVE-type" evidence="15">
        <location>
            <begin position="165"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="232"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="276"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="324"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="490"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="240"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="292"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="337"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="490"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="675"/>
            <end position="684"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR036956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CDM34580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="699" mass="76437" checksum="65138BCDC9126D97" modified="2014-04-16" version="1">MAGWFSSTSPLDEQIERATASSLEDIALNLEISDMIRSKSVQPKDGMRSLKRRLENKNPNIQLATLKLTDTCVKNGGTHFLAEIASREFMDNLVSLLKSEGAPLNAEVQGKILELIQNWAMAAQGRMDLMYLGETYRKLESEGYRFPPKTEMSGSMLESSAPPEWIDSEVCMRCRTAFSFMNRKHHCRNCGNVFDAQCSSKTIPLPHLGILQPVRVDDGCYAKLTSKSFAPPGISDRSAFKNNSISKSNTMEPRAGKPDTGFDEDLRRALQMSLDEAEGRGPSGFVPQTGNAPEPAKAVPKPENVDEEDPDLKAAIEASLRDMEQHKQNHAAALKNVPTSNSTLRDSSSTPTQLPKNPYELTPVETENIHLFSTLVDRLQHQPPGTILREPQIQELYESIGALRPKLARSYGETMSKHDTLLDLHAKLSTVVRYYDRMLEERLTRAYSQHNLGHGAVPGGAQYPNLQPAFSNHAPDVQSGAENFYYGTQMDSSRPPTTMYAPQQVNGDGFQVPSTYPSQAQHGAPTNESYGQNWGGNTYPALGSPPPSNGIPNNYANAPTPSAPAQYYAAPHDQDTARSPGAESPYQPSPIMRRDSSQYQAGATPSGPTPAPEQHASAGYVQSPGYSVPPTAPALHQQATGPSQSYYYPSQPQPQQPPNAVSSAYPPINAGQPGSYGQETSQPPYQQPARPVEENLIEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W6QDR1</accession>
    <name>W6QDR1_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ankyrin repeat-containing domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PROQFM164_S03g001560</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QDR1"/>
    <dbReference type="STRING" id="1365484.W6QDR1"/>
    <dbReference type="OMA" id="GHINIMQ"/>
    <dbReference type="OrthoDB" id="341259at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="24"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="58"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="91"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="124"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="157"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="254"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="287"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDM34833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="346" mass="36207" checksum="6D611E2DDC1EBBD6" modified="2014-04-16" version="1">MADIEPLRTCSCDRNEDDHQAPESQLTSVHQAVVEGNIELLEVLIRDGADISTTISSRDFTALHLAVQGGNEAATRLLIHAGANVSAPSYDGVTPLHNAAAGDPVAVAELLVKSGAEINARNIDHETPLHVVALFGNYQIAKLLIDVGSDISATECYGNTALHIAAGREHLEIVHSLLEAGADVNAINNNGDPVLHHAGRDDPTCVDLLLSHGADVYMKGEGGDTFLHRAAESSAELVRVALGADANVEATNDEGKTPLHSAAAYGEKQSIRLLLDAGANVNATTKIGETALHLIAGDSSIDESDEKARLLIDAGADINARTVSGQSALDLAKDSNATVIQVLCER</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W6QDS0</accession>
    <name>W6QDS0_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S02g002455</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QDS0"/>
    <dbReference type="STRING" id="1365484.W6QDS0"/>
    <dbReference type="OMA" id="EWFEGRI"/>
    <dbReference type="OrthoDB" id="10011777at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM32304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="105" mass="11963" checksum="F65D9895E8F983E3" modified="2014-04-16" version="1">MSEINATAILVPKPEKFEEVSTLVAEVIKQVEEHEPDTLLYYAFPIKDKNEIVIVESGDPDPRQITLFPNLRREIIHFIDEAGGDQGRWIPEWFEGRIATVVGCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W6QDV1</accession>
    <name>W6QDV1_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8">Eukaryotic translation initiation factor 2A</fullName>
            <shortName evidence="8">eIF-2A</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PROQFM164_S02g002505</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the WD repeat EIF2A family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QDV1"/>
    <dbReference type="STRING" id="1365484.W6QDV1"/>
    <dbReference type="OMA" id="RCCAYSP"/>
    <dbReference type="OrthoDB" id="2194683at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000596">
        <property type="entry name" value="Eukaryotic translation initiation factor 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011387">
        <property type="entry name" value="TIF2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013979">
        <property type="entry name" value="TIF_beta_prop-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13227">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13227:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08662">
        <property type="entry name" value="eIF2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017222">
        <property type="entry name" value="eIF2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 11" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="7 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 8" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Translation initiation factor beta propellor-like" evidence="10">
        <location>
            <begin position="213"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="471"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="516"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="578"/>
            <end position="596"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR017222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDM32354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="657" mass="71263" checksum="FD6EBDD9702B9E49" modified="2014-04-16" version="1">MAAPTQLAFRTLKGISIMDAAPVYQPLSGFAKPEGNLRCSGYSPCGRYFAWASPEKVTIIDPSVGQVVGTIPAENVFELGFSPLGTYVITWQRTSKDENGDAVKNLKVWRAIEDGDDHTIVGSFVQKSQTGWNLQYTADERLCARTVTNEVQFYQSDNLSTVWNKLRVEGVADFALSPGQSQSIAVFIPERKGQPAQVKVFIVPQFTSPVSQKSFFKGDKVQLKWNASGTTLIVLAQTEVDRTGKSYYGETTLYLLSASGAFDSRIDLDKEGPIHDVSWNPNSKEFGVVYGYMPTKTTIFNFRGVPKHNFPLAPRNTIQFSPHGRFVLVAGFGNLAGQMDIYDMDKNYHKITTVEASNASVCAWSPDGQYILTATTSPRLRVDNGVRIWHVTGGLVYNEEMTELYDVSWRPQSIEQHPLGEPLTKVPAPHPSALAYMGTRKAPVKPAGAYRPPGARGQLTPLAFKREDEGGAAFVRDGVPGASMNTFGKPRRREIPGAEPSEEYLPPGAAPGGGVALPAENLSKSAAKNKKKREAAKKAKEEGTEVPANAPTAPSSERSRNRGKNGTTNGNGPAKSTPTPPPAAPAPAPTPAPPAPVSVEDSSAQDKKVRGLLKKIRAIDELKMRLAGGEKLEDTQMKKIQTEDAVRKELQAVGYDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W6QE31</accession>
    <name>W6QE31_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S03</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S03g001005</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="1365484.W6QE31"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM34281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="126" mass="13575" checksum="64A8B0FAB5B8A93B" modified="2014-04-16" version="1">MQTVLRNINPSYEWVPLLATTGDNIAPPGGTAIQQGLTSDGRHRLLPKNPPIPQNLSIGMRPGISNSPWNLPQVETLENPATGGSAGSGEDLLDFTQSDMGWDFDFSTMDLDAFFSVYQSNSAPVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W6QE75</accession>
    <name>W6QE75_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S02g002655</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QE75"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM32504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="78" mass="8754" checksum="049312ACA254CCE7" modified="2014-04-16" version="1">MSSFPFSQLWEVRIEISHTAFFPLPFRNPSTCTHDPGPEPRQSHQEATSAASHNTSSSQNTSLVQSSDHLSKIPRLFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>W6QES8</accession>
    <name>W6QES8_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">serine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Seryl-tRNA synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Seryl-tRNA(Ser) synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">SES1</name>
        <name evidence="15" type="ORF">PROQFM164_S01g001898</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.11" evidence="2"/>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QES8"/>
    <dbReference type="STRING" id="1365484.W6QES8"/>
    <dbReference type="OMA" id="GYTPCFR"/>
    <dbReference type="OrthoDB" id="10264585at2759"/>
    <dbReference type="UniPathway" id="UPA00906">
        <property type="reaction ID" value="UER00895"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004828">
        <property type="term" value="F:serine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006434">
        <property type="term" value="P:seryl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00770">
        <property type="entry name" value="SerRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000026">
        <property type="entry name" value="Seryl-tRNA synthetase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.40">
        <property type="entry name" value="Serine-tRNA synthetase, tRNA binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002317">
        <property type="entry name" value="Ser-tRNA-ligase_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015866">
        <property type="entry name" value="Ser-tRNA-synth_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042103">
        <property type="entry name" value="SerRS_1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033729">
        <property type="entry name" value="SerRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010978">
        <property type="entry name" value="tRNA-bd_arm"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00414">
        <property type="entry name" value="serS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11778">
        <property type="entry name" value="SERYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02403">
        <property type="entry name" value="Seryl_tRNA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001529">
        <property type="entry name" value="Ser-tRNA-synth_IIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00981">
        <property type="entry name" value="TRNASYNTHSER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46589">
        <property type="entry name" value="tRNA-binding arm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 15" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="14">
        <location>
            <begin position="189"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="439"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="66"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="272"/>
            <end position="274"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="288"/>
            <end position="291"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="359"/>
            <end position="362"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="395"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for serine binding" evidence="10">
        <location>
            <position position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001529-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001529-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CDM28087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="470" mass="53588" checksum="DB6D4A8885780363" modified="2014-04-16" version="1">MLDLADFVTERGGDIKKIKESQQKRFAPEETVDEVVALYEEARRARYEVTQFGSQINGVQKAIGMKKKNKEDATELLAQKAELEIKKKELEETAVAKELQRDRKIRTIGNYVHESVPVSNDEADNQLIKTWTPENAEMQKPGCLSHHEVLTRLDGYDPERGVKIVGHRGYCLTGYGLFLNLALVNYGLEFLFNKGYTPNQPPQFMLKDLMAKTAQLEQFDEELYKVTESEDKSTDKYLIATSEQPLSALHDSEWLQDKELPIKYAGYSTCYRKEAGSHGKDAWGIFRVHQFEKIEQFVLTKPEDSWQAFEDMISTSEEFYQSLKLPYNIVAIVSGALNNAASKKYDLEAWFPFQQEYKELVSCSNCTDYQSRALEIRYGVKKTTDLKKTYVHALNSTLCATERTLCCVLENYQKEDGIVVPEVLRKYIPGAPEFLPYTKELPKDSTSTKAKGKASKGTDDATKKMQGLQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W6QF20</accession>
    <name>W6QF20_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA repair protein RAD51 homolog 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PROQFM164_S01g001993</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QF20"/>
    <dbReference type="STRING" id="1365484.W6QF20"/>
    <dbReference type="OMA" id="IACNALR"/>
    <dbReference type="OrthoDB" id="5957327at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033063">
        <property type="term" value="C:Rad51B-Rad51C-Rad51D-XRCC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033065">
        <property type="term" value="C:Rad51C-XRCC3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005657">
        <property type="term" value="C:replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008821">
        <property type="term" value="F:crossover junction DNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000400">
        <property type="term" value="F:four-way junction DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000707">
        <property type="term" value="P:meiotic DNA recombinase assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01393">
        <property type="entry name" value="RecA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052093">
        <property type="entry name" value="HR_Repair_Mediator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013632">
        <property type="entry name" value="Rad51_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46239:SF1">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD51 HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46239">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD51 HOMOLOG 3 RAD51C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08423">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecA family profile 1" evidence="9">
        <location>
            <begin position="37"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="288"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="297"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="323"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="366"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDM28182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="390" mass="42317" checksum="AF294FBBB2DB0652" modified="2014-04-16" version="1">MSINMDLLGLDGLEGFEDTPPVVSISASQSLNASAATRDPIATGLARLDEALNDLPDQSNQGGILRGHVTEIFGPPGAGKTSLALNIACNALRDGKVVWIDTGCPLPSLRLEEMSVNLDDFVYFRAHTLAHLIALLARPPKGFPPPETNLIVVDSVSNLFPAYFSSAQELKDQPTEGKFSDKTHLQWLINRKWNIASELAMHLARLAAKNIAVLAINQVRTEIKGQSHAVLQPLLSGSAWEASVQTRIAVYRDLPDERFAEVEKRAGKPLPEQAGLLVAFRIEPDGLYETEGKESPPSEPLTPLPKPSSDFEYYDPPTPTPSPISSVLSSAPSSAELESPSPSPSKLASPEQPVHTPIKKRKLEEVADSQDEDSEEENVPWTDETTLNTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W6QF56</accession>
    <name>W6QF56_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">beta-glucosidase</fullName>
            <ecNumber evidence="3">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BGL1B</name>
        <name evidence="8" type="ORF">PROQFM164_S03g001416</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Plays an important role in cellulose degradation. Shows hydrolytic activity against several glycosidic compounds.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyl hydrolase 1 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="3"/>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QF56"/>
    <dbReference type="STRING" id="1365484.W6QF56"/>
    <dbReference type="OMA" id="HGSNDFY"/>
    <dbReference type="OrthoDB" id="65569at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080079">
        <property type="term" value="F:cellobiose glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000011">
        <property type="entry name" value="Cytosolic beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033132">
        <property type="entry name" value="GH_1_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001360">
        <property type="entry name" value="Glyco_hydro_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353">
        <property type="entry name" value="GLYCOSYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353:SF36">
        <property type="entry name" value="LP05116P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00232">
        <property type="entry name" value="Glyco_hydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00131">
        <property type="entry name" value="GLHYDRLASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00653">
        <property type="entry name" value="GLYCOSYL_HYDROL_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00056775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM34691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="482" mass="54442" checksum="647B14D4A2239EF6" modified="2014-04-16" version="1">MESKQSTLPSDFLWGFATAAYQIEGAVNEDGRAPSIWDTFCKIPGKIAGGGTGDVACDSYHRTHEDIALLKECGSQAYRFSLSWSRIIPLGGRNDLINEKGIQFYQKFVDDLIDAGITPMVTLFHWDLPDELDKRYGGPLNKEEFVADFAHYARVVFEAFRSKVKYWITFNEPWCSSVLGYNNGSFAPGHTSDRTKSAVGDSSTEPWIVGHSLLVAHGAAVKIYRDEFKERDSGEIGITLNGDWAEPWDSENPADVEACDRKIEFAISWFADPIYHGKYPDSMIKQLGDRLPTWTPEDIALVQGSNDFYGMNHYCANFIRAKTGEPDINDVAGNLELLLEDKNGVGVGPITQSPWLRPSAIGFRKLLGWLSERYGYPKIYVTENGTSVLGENDMPLEELLNDEFRVQYFRDYIGAVADAYTHDGVNVRAYMAWSLMDNFEWAEGYETRFGVTFVDYENDQKRIPKKSAKEISRIFDRLIEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W6QFK6</accession>
    <name>W6QFK6_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Aldose 1-/Glucose-6-phosphate 1-epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PROQFM164_S01g002203</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldose epimerase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QFK6"/>
    <dbReference type="STRING" id="1365484.W6QFK6"/>
    <dbReference type="OMA" id="NWATYQF"/>
    <dbReference type="OrthoDB" id="274691at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004034">
        <property type="term" value="F:aldose 1-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033499">
        <property type="term" value="P:galactose catabolic process via UDP-galactose, Leloir pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09019">
        <property type="entry name" value="galactose_mutarotase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.98.10:FF:000014">
        <property type="entry name" value="Aldose 1-epimerase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008183">
        <property type="entry name" value="Aldose_1/G6P_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047215">
        <property type="entry name" value="Galactose_mutarotase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10091:SF6">
        <property type="entry name" value="1-EPIMERASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G13240)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10091">
        <property type="entry name" value="ALDOSE-1-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01263">
        <property type="entry name" value="Aldose_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004881563" evidence="4">
        <location>
            <begin position="21"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDM28392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="414" mass="44891" checksum="498C8F03DF120BB8" modified="2014-04-16" version="1">MHFKSYVTAALYGLPALANAAPSPSQAVPSPASDSNSDHFKSYTIKAENITAKLIPYGARLTSLLVPDRNGNVQDVIVGYDDPKEYLHDSETNRTFFGAVVGRYANRIKNGTFTIDDNTYHVPENENDGVDTLHGGFTGYDMRNWTVTSHSDASITFTLFDQGFEKFPGDVITHATFSVSTEKTPANPKGLPQLTSKLVALSLTEKTPIMLSNHIYWNLNAFKEPNVLKDTTLQLPLSQRFVGGDSILIPNGTIHDVEKAYQGALDFTSPKLIGKDIEKTYDLCGAGCTGYDTCFLVDRPSTYASNSIATVLSASSSSTGISLDVATNQAALQIYTCSGQNGSIATKNSQAKRNEADGGDSGATHVNKYGCFVIETEDWIDGINNPEWGRIPYQIFGPDDGPAVNWATYQFGTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W6QGD8</accession>
    <name>W6QGD8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S04</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S04g000759</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QGD8"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM35878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="54" mass="5650" checksum="9CAB1A68F58C6AFD" modified="2014-04-16" version="1">MAFNPAFAHGFQPTPASPAQTCYTFTGSDPACDHSVQDPPSPRPFPPNPPPSPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W6QH78</accession>
    <name>W6QH78_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">S-adenosyl-L-methionine dependent methyltransferase, predicted</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S04g000646</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QH78"/>
    <dbReference type="STRING" id="1365484.W6QH78"/>
    <dbReference type="OMA" id="HQGRYDF"/>
    <dbReference type="OrthoDB" id="514248at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010286">
        <property type="entry name" value="METTL16/RlmF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13393:SF0">
        <property type="entry name" value="RNA N6-ADENOSINE-METHYLTRANSFERASE METTL16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13393">
        <property type="entry name" value="SAM-DEPENDENT METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05971">
        <property type="entry name" value="Methyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM35765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="433" mass="48650" checksum="257A05791168CC3B" modified="2014-04-16" version="1">MEYVRSLYKNDVDFAALGLQSRDFAKHLKQNGQLDFTDPAAVRQLTTTLLQQDFDLKVEIPEDRLCPPVPNRLNYILWLHDLLDSTAGGLHEECDRDREVVGLDIGTGCIAIYPLLGCATRPLWKFVATDIDSNNIRTSQHNVALNNLRSRIQIVNSDPNGPLFPLEKLGHQTLDFTMCNPPFYASPNELKQSAEQKERDPFSTCTGAEVEMVTHGGEVAFVKQMIDESLQLRDRIQWYTSMLGKLSSINVLVEMLIKHGITNFAVTEFEQGSKTKRWAVAWSLGDRRPAMNIARGIPGCPKSLLPFPADYTFTLPPGTSIDTATATIDTELSSLPWFWTWNQTRSAGTGFASENVWSRFARRKMKLAGEEGAAKFKAIPDQVALGVRLQIRLVRGQKPDEREVKALVRWAQGTDTVLFESFCGMVKRKLESN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>W6QHG5</accession>
    <name>W6QHG5_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Glutamate decarboxylase</fullName>
            <ecNumber evidence="3 9">4.1.1.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PROQFM164_S04g000302</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 9">
            <text>L-glutamate + H(+) = 4-aminobutanoate + CO2</text>
            <dbReference type="Rhea" id="RHEA:17785"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:59888"/>
            <dbReference type="EC" id="4.1.1.15"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7 8">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the group II decarboxylase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.15" evidence="3 9"/>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QHG5"/>
    <dbReference type="STRING" id="1365484.W6QHG5"/>
    <dbReference type="OMA" id="HRECADI"/>
    <dbReference type="OrthoDB" id="5152799at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004351">
        <property type="term" value="F:glutamate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006538">
        <property type="term" value="P:L-glutamate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010107">
        <property type="entry name" value="Glutamate_decarboxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01788">
        <property type="entry name" value="Glu-decarb-GAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43321">
        <property type="entry name" value="GLUTAMATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43321:SF3">
        <property type="entry name" value="GLUTAMATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="5 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 7 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7">
        <location>
            <position position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDM35421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="462" mass="51294" checksum="7C711A72EFA57C1F" modified="2014-04-16" version="1">MPSNRSPTPLPSKGYMPDRGLSVETVRAFAENVMAADIPPSHDLGRFTTTKFDETAIDLMISGGLRNQACIHEYPSLADYREKCLSILANLWNAPNGFFGAATTGSSESVLLGGLAMKREWQLNHPNHLYPRPNVIIGANAHVCVNKFAFYFDVEARIIPVSERSGYSLDIEGLEDRLDENTIGVFLTMGSTYTGHCDLVQQVANVLDAYELRTGNNIPIHIDAASGGFILPFTSTNTNFVWDFRLSRVQSINASGHKFGMAPLAVGWILWREKSQIPQGLLVESSYLRGTHSDFSLSFSRSGAPIAGQYYNFLRLGLAGYQDRTQSLLDRARRLSVLLEETGYFYCLSDAHRQQKAGVGYTLCKGSDQAVPHVLPIAVFRLSDQARRQYPNLQLSDISDAMHDLKFSIPNYTIRGWGAHGEDIEVMRIVLRDEMTAELMTKVLAGMTQSVKRLIDQASVQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>W6QHY8</accession>
    <name>W6QHY8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Zinc finger, CCHC-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PROQFM164_S01g003024</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QHY8"/>
    <dbReference type="STRING" id="1365484.W6QHY8"/>
    <dbReference type="OMA" id="NVPDHEP"/>
    <dbReference type="OrthoDB" id="106784at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16620">
        <property type="entry name" value="vRING-HC-C4C4_RBBP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014891">
        <property type="entry name" value="DWNN_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033489">
        <property type="entry name" value="RBBP6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025829">
        <property type="entry name" value="Zn_knuckle_CX2CX3GHX4C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15439:SF0">
        <property type="entry name" value="CELL DIVISION CYCLE AND APOPTOSIS REGULATOR PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15439">
        <property type="entry name" value="RETINOBLASTOMA-BINDING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08783">
        <property type="entry name" value="DWNN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13696">
        <property type="entry name" value="zf-CCHC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01180">
        <property type="entry name" value="DWNN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51282">
        <property type="entry name" value="DWNN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DWNN" evidence="9">
        <location>
            <begin position="5"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="8">
        <location>
            <begin position="184"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="97"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="216"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="360"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="563"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="107"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="360"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="395"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="563"/>
            <end position="587"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDM29212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="620" mass="67807" checksum="CBA5FD0F24B3F6A3" modified="2014-04-16" version="1">MSSSVHFKFKSQKEPSRVTFDGTGISVFELKREIISQSRLGDGSDFELSIYNEDTREEYDDDTTIIPRSTSVIARRLPAARPGKGGAARYVSGKMPVNARSAPRNEPSMSRVTPGSGQSVNNNVLELNNAQTEEEKINALFNLQASQWQEQQQEMANATPVPFGRGRGKPVNVPDHPPPPGYLCYRCREKGHWIQACPTNNDPKFDGKYRVKRSTGIPRSLQTKVDKPESLAPDGSTEDSRNTGVMVNADGDFVIAKPDKAAWELYQEKAKASAAAAAEAAAAEESKALQARGLECPIDKRMFLEPTKTPCCQRTYCNDCISNALIESDFVCPGCATEGVLLDNLTPDDEAASKIKEYEADKAEAKKEKDKVVAGPNGTPIPDVSETEPKESSATKEQSPLNQTQETASTQSRKRPAEDEPISRNETANSEPGNVLKKQKADDGHSDVPTQANSVQDGAPGVAPVNFNNQDMPFNSFGPMQGMPMMPFSAPGFGNEAMGFMNPMAMASANGFPGGMGPGWNPMNMPFNPLQAGMFDQSNGGMPNGFPNMFNGDPSMMFPMPQNGFQGPNSGMNNFSNQQRTAFSTPYSREEDSPYFRQPVNPQRHQARNRRVRPSDYREL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W6QI12</accession>
    <name>W6QI12_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ankyrin repeat-containing domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S04g000532</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QI12"/>
    <dbReference type="STRING" id="1365484.W6QI12"/>
    <dbReference type="OrthoDB" id="4807664at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050745">
        <property type="entry name" value="Multifunctional_regulatory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24189:SF50">
        <property type="entry name" value="ANKYRIN REPEAT AND SOCS BOX PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24189">
        <property type="entry name" value="MYOTROPHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="118"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM35651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="175" mass="19118" checksum="302FC390EA9E3661" modified="2014-04-16" version="1">MMEEMPKFVLDHEPGVCSLSDHFGASKDLETHQKQAPEEILQYSRQSQQQKSTDDWNQCIYADAAIGGPREPTKRYIAEDKGGTTLGGQHCTTQHTAHIKIVAELLIAGADPEARDNEGRSPLHAAADAECEPIIRLLVREGADLNAAIGISGISSSEEGDMPFSWWIEPMDACS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W6QJC9</accession>
    <name>W6QJC9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Alcohol dehydrogenase superfamily, zinc-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PROQFM164_S03g001018</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QJC9"/>
    <dbReference type="STRING" id="1365484.W6QJC9"/>
    <dbReference type="OMA" id="CWDDKET"/>
    <dbReference type="OrthoDB" id="1879366at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08297">
        <property type="entry name" value="CAD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000039">
        <property type="entry name" value="Alcohol dehydrogenase AdhP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940:SF1">
        <property type="entry name" value="ENOYL REDUCTASE (ER) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="8">
        <location>
            <begin position="25"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM34294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="367" mass="38739" checksum="E000CAF94229BDE8" modified="2014-04-16" version="1">MGSVIDYSQVEIPTHCKAGVVINEGPDFHVEVQTVPVPEPGPDDVLIKLNYTGLCSSDIHMMQGDLGLPFMSAFDVRSPGHEGAGVVVKVGANVKTFKLGDRAGIKPILDTCGSCALCWDDKETYCKGAILTGLMTTGTYQQYLVSPARYASPIPDGVPDEIAGPIMCSASTIYRSLVESNLRSGAWVVFPGGGGGVGIQGVQLAKAMGMRPIVVDTGESKQKLSLEMGAEAFVDFKEVADSTKAVIGIADGVGAHGVFVTAPAAYKTAVSFIGDRIGGIVMCIGLPVAGSMTIGADPCQYVFKNLTIKGTLVGSRSDTAMALDFARRGALRQISEVYPLNRMPEAVEKLRKGEVAGRIVINFNWEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W6QJF9</accession>
    <name>W6QJF9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g003529</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QJF9"/>
    <dbReference type="OMA" id="MWGALDS"/>
    <dbReference type="OrthoDB" id="5819478at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36851:SF1">
        <property type="entry name" value="GLYCO_TRANS_2-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36851">
        <property type="entry name" value="UNNAMED PRODUCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13632">
        <property type="entry name" value="Glyco_trans_2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="1">
        <location>
            <begin position="200"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM29717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="534" mass="59757" checksum="47894E49F0EA5916" modified="2014-04-16" version="1">MDFGEDSATRPLDGLTLPCVDRGQVKPDFGSHRSIVAVNFHDVALQRRHSTTPKSVDTEDAFEAELAGNVPLSVLGGTQFEAEPDYLVNNQEVVHAIILPNYEENFDTLWTTLHVLASHPRAASQYEIYLAMEQKELEAPAKAVSLVSTFETRFSHIEATFHPSGVPGEIAGKSSNVAYAAQRIINSHRRDDREDLTNKLITVIDADTHLLQDYFNEIQRLHFDDIASPELSFYTCPIIFDRNSSETPILVRCADMMWAFAGVSAMYPGSPISIPTSVYTLPLSMAERVGGWDSDAGAIGEDMHMLLKCYFAMDGNITTRVVASPVSQCNISSNEHRGWRQNMDILAARYRQALRHMWGALDTGFFIRQSAANLSRPSWRILFSGTQWALAHLLFEAHFLPCHLIITLAISSIYSAFISPESMHPDLEWTFQFTGVLRVCSFIMMNICMIVYGHWHNFCVNTRLTDMMDAGVPDAGFSFRNEWNGGTLLERILFPVAGTLFGPVPAIQAVFSHFWTDRLVYKVSQKPSFGPSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W6QK46</accession>
    <name>W6QK46_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">1,3-beta-glucanosyltransferase</fullName>
            <ecNumber evidence="8">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PROQFM164_S02g000101</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Splits internally a 1,3-beta-glucan molecule and transfers the newly generated reducing end (the donor) to the non-reducing end of another 1,3-beta-glucan molecule (the acceptor) forming a 1,3-beta linkage, resulting in the elongation of 1,3-beta-glucan chains in the cell wall. Involved in cell wall morphogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Cell membrane</location>
            <topology evidence="1 8">Lipid-anchor</topology>
            <topology evidence="1 8">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glycosyl hydrolase 72 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="8"/>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM29952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QK46"/>
    <dbReference type="STRING" id="1365484.W6QK46"/>
    <dbReference type="OMA" id="QDHTECM"/>
    <dbReference type="OrthoDB" id="421038at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042124">
        <property type="term" value="F:1,3-beta-glucanosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071970">
        <property type="term" value="P:fungal-type cell wall (1-&gt;3)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000038">
        <property type="entry name" value="1,3-beta-glucanosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004886">
        <property type="entry name" value="Glucanosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012946">
        <property type="entry name" value="X8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31468:SF9">
        <property type="entry name" value="1,3-BETA-GLUCANOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31468">
        <property type="entry name" value="1,3-BETA-GLUCANOSYLTRANSFERASE GAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03198">
        <property type="entry name" value="Glyco_hydro_72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07983">
        <property type="entry name" value="X8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00768">
        <property type="entry name" value="X8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="6 8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <keyword evidence="8 11" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005151055" description="1,3-beta-glucanosyltransferase" evidence="8">
        <location>
            <begin position="18"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="domain" description="X8" evidence="10">
        <location>
            <begin position="371"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="468"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDM29952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="529" mass="56254" checksum="237E556E204D0FB8" modified="2014-04-16" version="1">MKFSLVALATLAGVAVADLDPIIIKGSKFFYSSNDTQFFMRGVAYQQESTSSSGYTDPLADATACARDVPIMAELRTNVIRTYAINASADHSACMKLLSEAGIYVISDLSDPDLSIDRNDPSWTTNLFARYTSVVDELAQYNNTIGFFAGNEVSNTIATSDASAFVKAAVRDTKKYIKEKGYRSMGVGYATADVSDIRADMADYFDCGDAEDSIDFWGYNIYSWCGNSTYAKSKYQARTEEFANYSVPVFFAEYGCNEVTPREFTEVKALYGDTMAEVWSGGIVYMYFQEANNYGLVSVVDSTSVKTMSDFKYYSSQIANANPTGVNKASYTPTNTALQSCPTVGASWDAKSSPLPPAADSQLCECMYDASACVVAGSLASTKYANLFSTVCGYTDCSGLTANATTGEYGAYSMCSTKQQLAFALNKYYVEQDRAADACSFSGSATVKASTKATGTCSTQIKEAGTAGTGTVTTENTATADSSSASSTASSSTSSSGAIRVHHSSSFGSFQVAAYIATALLAGVGMIAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W6QKF2</accession>
    <name>W6QKF2_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major facilitator superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PROQFM164_S03g001419</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QKF2"/>
    <dbReference type="STRING" id="1365484.W6QKF2"/>
    <dbReference type="OMA" id="FLWLMPD"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000064">
        <property type="entry name" value="MFS allantoate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000453">
        <property type="entry name" value="MFS allantoate transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF97">
        <property type="entry name" value="ALLANTOATE TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G14700)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="185"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="324"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="353"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="378"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="413"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="441"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="59"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM34694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="513" mass="56238" checksum="F7418A04213E128F" modified="2014-04-16" version="1">MNPNDTKEDHSTAEKDVTHVALGETHDIGANLYLEAEQLTAEELETEGAEVLRILDWRVMPVLYLTYVIQFLDKLSLNYASAYSLIPDLGLEGQRYSWVAAIFNFGYLFWALPANLLIQRLPIAKYMGGMLLIWSVLVIAHVGAKNYGGILVLRFLLGMAEAGVSPCMMNLTSMFYKRSEQPLRMAVWLSANGMATMVGALLGFGLGHSHNTALRSWQLIFLTIGLLNFLTACIFLWLMPDSPSSARFLTHRQRVIAVQRVAENMIGVKTREIKPRQALEILYDFRVLCCAGVGIACGVINGGSSNFASALIKGYGFSGIYTTLLQLPTGAIEAVVVPICGIIATYVKDSRCIVLAVVSLIPFGGLLGIRFTSLDHRWTLVGCTWLQYIIGAPVIISWNLLATNVAGHTKRAVANGLWFSLYAAGNVAGANIFFADEAPRYYSGLLGLLICYAGIIVLACATYISMKMENRRRDAAAVAAGSDETPEDITSQAILDGFKDLTDMESKHFRYAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W6QKY9</accession>
    <name>W6QKY9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S06g000075</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792020">
        <property type="protein sequence ID" value="CDM37115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QKY9"/>
    <dbReference type="OMA" id="MKPTQEY"/>
    <dbReference type="OrthoDB" id="3490397at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004880309" evidence="1">
        <location>
            <begin position="18"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM37115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="144" mass="15884" checksum="38168DD82B338A78" modified="2014-04-16" version="1">MQLTTILPIVLAGLASARPASLQTKTITDDIIWGVSNFTIGCSPGGCVYRYDIVGRENTMTPKFRTNCSGVTDERVLCDDKNITTIVSPAENPVWNVDVTHTWKSQLSDNTLATWYQHGAKNVTVPDHNPIQFVMKPTQEYGIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W6QL14</accession>
    <name>W6QL14_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S06g000490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792020">
        <property type="protein sequence ID" value="CDM37528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QL14"/>
    <dbReference type="STRING" id="1365484.W6QL14"/>
    <dbReference type="OMA" id="GSGPWFY"/>
    <dbReference type="OrthoDB" id="2349272at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004879700" evidence="1">
        <location>
            <begin position="21"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM37528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="215" mass="23127" checksum="A651584E9814A595" modified="2014-04-16" version="1">MHLQTLLLTLTLTLTIQTTATPLPTTLFTRNRNNAALTESQLVTIAPSSKSCTDAPAAGECATAKQAAKFTSQSFDTYKVTSKAEQAAVISLMAFESGDFKYNKNHFPGVAGQGTRNMQSPSFNKKYAASLPALKDKLATVNGPAELLDLLRNDGATDFGSGAWFLTTQCSKEVRAALADGSETGWQRFISDCVGTSVTDERKEYWERAVKAIGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W6QLE8</accession>
    <name>W6QLE8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribonuclease P, Rpp40</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S05g000629</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QLE8"/>
    <dbReference type="STRING" id="1365484.W6QLE8"/>
    <dbReference type="OMA" id="DVDPYLC"/>
    <dbReference type="OrthoDB" id="63112at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030681">
        <property type="term" value="C:multimeric ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000172">
        <property type="term" value="C:ribonuclease MRP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000171">
        <property type="term" value="F:ribonuclease MRP activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004526">
        <property type="term" value="F:ribonuclease P activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013893">
        <property type="entry name" value="RNase_P_Rpp40"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15396">
        <property type="entry name" value="RIBONUCLEASE P PROTEIN SUBUNIT P40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15396:SF1">
        <property type="entry name" value="RIBONUCLEASE P PROTEIN SUBUNIT P40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08584">
        <property type="entry name" value="Ribonuc_P_40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM36796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="401" mass="44830" checksum="4735666992B4FCF5" modified="2014-04-16" version="1">MFQEVDESSRREKCFTTITQLPAFINPKQVPSKRSPFSTIQNHAFVHSVEVILPKEFYSQIKPSLETKLEKPRYARVFMTPSALLEHEFFNTYIKSGNILMISEGRSGSDNVFTLKDGKEIYERTGLTGKPFRSGGRKHAKERFLVELNLRLPSMLHGKKGFERIVWAFTNVLTQSMAWLFHDLESNPGPGEGDHVSEAKKGNSSKNILKVGAGNKPIDKVQPQLITCEPQEIAHEQIITPPFYENGKVLENMSEDDLQEYCGSLSEWIAMVQMASPRLSGEDDVDPYLSRYAAPDAEEGQASDLMSLKWHGLISSRWTMQLFLNMLQNTKASWFALAVATLGKEAVEGRDGFMVMVLPSGQSSAQSSESSQTSQVKDEGTVGTGRVTFCWELMGASVTEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>W6QLT7</accession>
    <name>W6QLT7_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Probable transposable element</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PROQFM164_S07g000111</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792021">
        <property type="protein sequence ID" value="CDM37763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QLT7"/>
    <dbReference type="STRING" id="1365484.W6QLT7"/>
    <dbReference type="OMA" id="LGRNYSH"/>
    <dbReference type="OrthoDB" id="423559at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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            <begin position="1005"/>
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    <sequence length="1179" mass="132017" checksum="39D64EC32944B7DF" modified="2014-04-16" version="1">MASSVDQSQEDKIKDLLEDLDTYRYIYDDLLATRGPCAEADELRDTIKNMEVQVATLLGDPVPTSQAAPTPQVTSPTPPVRTPAATPRKASNTFTGIPGDSFASPHWPSAAPSPFAAGSGQSILLPASSMIQPSPDNSRKRQRPLSQVSPTIQGSSKRIAPSQPKSHRSKLDEIDAAQEARLAENQRLYKHWIDAAGDDADEINELREECEEQAKLIETEFQMERDAELARALQADEDHSQLPRSNECHTWNIPDRSQPVKLEHLSSNPNRAPQAYAPIAPFNKLNPFNSDDDLQEITADSFKDRSGKQPARPSSSYPHLPSLPSQYSKSPYTSQGLYPSRMPYPSELTYPSQLPYPSELTYPSQMSYPSQLPYPSQLAYPSQLSNPSMPYSTSAAASRNLPWSHEHPYATMPGTFEKYDKFDKFDKAFDLVRNQSEIFDDDADIVAYNEKEFPEDIKNLLSGIKDIREATKADNDETPSALRVTLMKHQKIGLRWMKAKEESNHKGGILADDMGLGKTIQAIALMVARPFEDEDRRPTLIVAPKALMDQWRLEIQRHVKPGRHQLSVLIYHQRRRPWKELKRYDIIITTFGTITAHYKTLLQAEKLAEEGRDPSIIQDLKNAAGPLSPAAKWHRVIIDEAQNIKNPSAKSAIACCRLNATYRWCLTGTPMMNRLEDFQSLLGFLRIRPYSNPAKFKADFVRRIKSGWGGEDVMKQLRVLVKSVCLRRTKSSKIDGEPILQLPPKVTEKVHVVFDERESQVYEELNTSTQRQITRYLDSGTLGRNYSHVLVLLLRLRQACCHPLLMQDFRNEPSPSIPGVDKIANAKLLTAAVVQRIKDNDGEEDGTCPVCMDSVKNATIYIPCGHHVCSECWIRISDSATANGAINLEDDGPAVIKCQNCRGPVDPAKLTDTNAFKQVHDPTSVPEFAAGGGDTNGPNDDEDPEATASSEESDSDSSTGEGDAESKKKTKAKSLAQLRKDALRNKAEKKKYIRRLEKGWFPSTKITKTLEILQANEDRGLEEKTIIFSQFTSLLDLLEVPLARRGWNHTRFDGSMNLKERNAAVTAFTNDPDCKIMLVSLKAGNSGLNLVAASHVIMFDPFWNPYIEDQAVDRAHRIGQVREVFVHRLLIENTVEDRIVTLQDQKRELISGALDEGGTMNVSRLDARELAYLFGVRDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W6QLZ6</accession>
    <name>W6QLZ6_PENRF</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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        <name evidence="2" type="ORF">PROQFM164_S07g000191</name>
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        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
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                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">FM164</strain>
        </source>
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            <dbReference type="EMBL" id="CDM37843.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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    <sequence length="36" mass="3871" checksum="81884B253BC60DAA" modified="2014-04-16" version="1">MAPFAQLSHFGPKGSGMVNVPSGMRPANDQHLFTSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W6QMH9</accession>
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        <lineage>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
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                <person name="Renault P."/>
                <person name="Dupont J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="9">FM164</strain>
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        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
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        <property type="entry name" value="WD40_repeat_CS"/>
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        <property type="entry name" value="WD40_rpt"/>
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        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID"/>
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    </dbReference>
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        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
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        <property type="entry name" value="GPROTEINBRPT"/>
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        <property type="match status" value="7"/>
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        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
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        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0678">Repressor</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2 6" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Transcriptional repressor Tup1 N-terminal" evidence="8">
        <location>
            <begin position="15"/>
            <end position="83"/>
        </location>
    </feature>
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        <location>
            <begin position="333"/>
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        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="368"/>
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        </location>
    </feature>
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        <location>
            <begin position="409"/>
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        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="454"/>
            <end position="487"/>
        </location>
    </feature>
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        <location>
            <begin position="508"/>
            <end position="549"/>
        </location>
    </feature>
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        <location>
            <begin position="550"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="84"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="131"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="220"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM37630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="589" mass="64058" checksum="19FF1CEA3DEEDC8C" modified="2014-04-16" version="1">MYNAHRGMVPAPNSRLTELLDQLRQEFESQSRNTGEFEHQLTGQLQEMEMIRQKVYQLEQAQIKIKQDYEAEIRMLRHELESRGVQSIPSHIGGPAAAHTAPSQAPPPALGHGPSNLFGGIMTNPPGSGPGLAPSLPQDQQPPQHPLQQPASVAQPGAPQPQQSSFGGYPAGAAVNGYGPPPPPTASPGPGKGRGRVPPGPGTPQQTHIAYPDPRASPQIPRPTPPNPPLGRTAERPGNMLANWNPDDLPPSQKREGSDWYAVFNPEVQRVLDVELVHHLNHDSVVCCVRFSRDGKYLATGCNRSAQIFDVTTGQNVATLQDENVDKDGDLYIRSVCFSPDGKYLATGAEDKQIRVWDINQRTIKHIFSGHEQDIYSLDFAGNGRFIASGSGDKTVRLWDILDGKLVYTLSIEDGVTTVAMSPDGRYVAAGSLDKSVRVWDTTTGYLVERLESPDGHKDSVYSVAFAPNGRDLVSGSLDKTIKLWELTVPRGMHPHSAVKGGKCIRTFEGHKDFVLSVCLTPDGAWVMSGSKDRGVQFWDPVTGNAQMMLQGHKNSVISVAPSPTGNLFATGSGDMRARIWRYSAYTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W6QMK3</accession>
    <name>W6QMK3_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">peptidyl-tRNA hydrolase</fullName>
            <ecNumber evidence="1">3.1.1.29</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PROQFM164_S04g000290</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>an N-acyl-L-alpha-aminoacyl-tRNA + H2O = an N-acyl-L-amino acid + a tRNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54448"/>
            <dbReference type="Rhea" id="RHEA-COMP:10123"/>
            <dbReference type="Rhea" id="RHEA-COMP:13883"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:59874"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:138191"/>
            <dbReference type="EC" id="3.1.1.29"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PTH2 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.29" evidence="1"/>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QMK3"/>
    <dbReference type="STRING" id="1365484.W6QMK3"/>
    <dbReference type="OMA" id="RMDLGMT"/>
    <dbReference type="OrthoDB" id="1733656at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004045">
        <property type="term" value="F:peptidyl-tRNA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd02430">
        <property type="entry name" value="PTH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1490.10:FF:000001">
        <property type="entry name" value="Peptidyl-tRNA hydrolase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1490.10">
        <property type="entry name" value="Bit1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023476">
        <property type="entry name" value="Pep_tRNA_hydro_II_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002833">
        <property type="entry name" value="PTH2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00283">
        <property type="entry name" value="arch_pth2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12649">
        <property type="entry name" value="PEPTIDYL-TRNA HYDROLASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12649:SF11">
        <property type="entry name" value="PEPTIDYL-TRNA HYDROLASE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01981">
        <property type="entry name" value="PTH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102462">
        <property type="entry name" value="Peptidyl-tRNA hydrolase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="52"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM35409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="209" mass="22485" checksum="2A59DB75C6185FFF" modified="2014-04-16" version="1">MAAPVPLDRIPPTTAAYVIATAIIAGVTGYFIGQGSSISLFKEKEGWPNSYDVKVHSHSSDEEDESDSEEGETDEEDEGNGEELSSFKDNSEEVKLVLVVRMDLGMTKGKIAAQCGHATLACYKYFLEYAPESPILRKWERGGQAKIALQVKSEDELLVMQAQAISLGLCARVIQDAGRTQIASGSKTVLGILGPRSVVDGVTGHLKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W6QPG6</accession>
    <name>W6QPG6_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PROQFM164_S04g000880</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QPG6"/>
    <dbReference type="STRING" id="1365484.W6QPG6"/>
    <dbReference type="OMA" id="TITGRPH"/>
    <dbReference type="OrthoDB" id="5979581at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050684">
        <property type="term" value="P:regulation of mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051334">
        <property type="entry name" value="SRPK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634:SF9">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="35"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDM35999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="209" mass="24105" checksum="3CB1859AB5DC3BF2" modified="2014-04-16" version="1">MRRFERIHNVVEPIEEYRIGGYHPVHLEDTFHHRYRIVAKWAFGQFSTVWIAEDTRLGRYITLKILKADIPSSSRERSILLHLSKVDTHHPGRNHVLQLLDHFEHKGPNGLHICLVFPVMISDGGAMTVREKPRCPGYVREVSKQILLGLNYLHDQGLIHGDLQPANILFTLNCDLSSEMIEEPEFSHVNWLPGVEVDDSAPRYLMSSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W6QPN1</accession>
    <name>W6QPN1_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S08g000001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792022">
        <property type="protein sequence ID" value="CDM37951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QPN1"/>
    <dbReference type="STRING" id="1365484.W6QPN1"/>
    <dbReference type="OMA" id="WENFMAR"/>
    <dbReference type="OrthoDB" id="4424523at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM37951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="289" mass="33531" checksum="D23108B2BE85FAC3" modified="2014-04-16" version="1">MTTRRILQTTRHLPIYSQFARPSVTRPTFFRFPFEPPSRLAKSLSTSHFNTIRSLSTSTTMASRSKRDPTMYSFMNGADLVEGLLKEDGFTTWGFVIFRCTYHNDSDWENFMARMVGAVSEDLKEYSGLDLLDTFAPTVLEDPSFEGATVATLREHFYQWKKTALKEEQGVSEDYTPTSGRYRFFITVDQEAMESVLNTPLGGFEEYELGHVRMVNAEWKWTDVPEEDSEDEDISEPEEFEPLEGCTEDDVGWMNIRWRIVQLPGFHKMTEIDDWQAYYVRYPGIADIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W6QR98</accession>
    <name>W6QR98_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Zinc finger C2H2-type/integrase DNA-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PROQFM164_S02g002223</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QR98"/>
    <dbReference type="STRING" id="1365484.W6QR98"/>
    <dbReference type="OMA" id="PRQDHLV"/>
    <dbReference type="OrthoDB" id="2687452at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000100">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="132"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM32072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="207" mass="23119" checksum="07124808A94B1613" modified="2014-04-16" version="1">MQSPFNYPDSYSSSYSSSPGSMDFFFYGGQPVYDSLCDLDATSPFPMQEVAPELYNVTSSPYTYQTPHDYPVFDRPTMPQSTPSSCGSSYSSSYSSSFTFPSEDIALPTYPISEYESNAESPAPASKPAKPFGCDNCGKSFTRFADLKRHQSSVHYPVFRNCPVEHCSRKGSNGFPRQDHLVEHLRSYHHMDVPKRGACKRSAKQIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W6QRK5</accession>
    <name>W6QRK5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S02g002328</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QRK5"/>
    <dbReference type="OMA" id="SSKHTTC"/>
    <dbReference type="OrthoDB" id="4483326at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM32177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="113" mass="12968" checksum="8236B08CCC57B330" modified="2014-04-16" version="1">MSYKTNYELYSRGSIDSRRSPPPSDELLSPLATLYPHVAALQPQYNPSNCTFTGYRETGYWAAAYTTQPVDDSSISMRRHDGRPCRFVSRIRRLLSRDDLKYRRGSRATARTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W6QT95</accession>
    <name>W6QT95_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ankyrin repeat-containing domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S02g002888</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QT95"/>
    <dbReference type="STRING" id="1365484.W6QT95"/>
    <dbReference type="OMA" id="PCDEIAV"/>
    <dbReference type="OrthoDB" id="4305729at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="112"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM32737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="176" mass="20180" checksum="92907E884E951CA3" modified="2014-04-16" version="1">MFINGPDCEVYLGTRNAQDSELPLHKVVLYRSIDTVKWRLRQKGLNLDIQDWKGYTPLYLALLTVPRITLNLCVVGHSPISVTIYHGYVKTIAYLLSIEGVEINRRGLIDLPIYRAVLYGYLDIVRLLVQQGVRLNVNESTVATYDTALYITAYGGDLEMVWELLRHSRIDINLRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W6QUD6</accession>
    <name>W6QUD6_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S02g003294</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM33142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QUD6"/>
    <dbReference type="OMA" id="THRITQP"/>
    <dbReference type="OrthoDB" id="3913483at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM33142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="117" mass="12548" checksum="74194DE3D923C553" modified="2014-04-16" version="1">MSDSTFHTTTQDIRKAESKLAQSHDGKPPANSDVSQTKSIIDQNTNKPAEIEKTKANLPLPDQPPVASDFNSLDQRTTNVGSGRFEYPPDNSGLREGAAASSSARIDGKELHKSTAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W6QVH7</accession>
    <name>W6QVH7_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RPEL repeat</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PROQFM164_S09g000045</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792023">
        <property type="protein sequence ID" value="CDM38129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QVH7"/>
    <dbReference type="STRING" id="1365484.W6QVH7"/>
    <dbReference type="OMA" id="QCRPDAQ"/>
    <dbReference type="OrthoDB" id="197676at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043451">
        <property type="entry name" value="Myocardin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004018">
        <property type="entry name" value="RPEL_repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22793:SF12">
        <property type="entry name" value="MYOCARDIN-RELATED TRANSCRIPTION FACTOR, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22793">
        <property type="entry name" value="MYOCARDIN-RELATED TRANSCRIPTION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02755">
        <property type="entry name" value="RPEL"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00707">
        <property type="entry name" value="RPEL"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51073">
        <property type="entry name" value="RPEL"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="RPEL" evidence="4">
        <location>
            <begin position="16"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="repeat" description="RPEL" evidence="4">
        <location>
            <begin position="60"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="repeat" description="RPEL" evidence="4">
        <location>
            <begin position="104"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="106"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDM38129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="135" mass="15423" checksum="10D5F2AC7F4AC870" modified="2014-04-16" version="1">MSSVQQSLPPTYERRNSLEKHLQTRPEMQDLKNRHILLDTNVAPAIQSARQVLDRQRATDSLKKNLEKRPEKDELVERNILPATSAAPALQAPARELEKHMLADNLEHKIQNRPQPEDLISQGILSEDENPRSPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W6QW85</accession>
    <name>W6QW85_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Probable transposable element</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S12g000033</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792026">
        <property type="protein sequence ID" value="CDM38424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QW85"/>
    <dbReference type="STRING" id="1365484.W6QW85"/>
    <dbReference type="OrthoDB" id="4365515at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM38424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="65" mass="7335" checksum="F58EF1CD82254C25" modified="2014-04-16" version="1">MIFKLAHQRAIFRNQRQATATILCDSRSALQAIQNVRNRSGQRIIHAILQAATEVQAGHISLRLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W6QWF8</accession>
    <name>W6QWF8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Genomic scaffold, ProqFM164S03</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PROQFM164_S03g000571</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RBT5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QWF8"/>
    <dbReference type="STRING" id="1365484.W6QWF8"/>
    <dbReference type="OMA" id="CCKRWRR"/>
    <dbReference type="OrthoDB" id="3946741at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008427">
        <property type="entry name" value="Extracellular_membr_CFEM_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52012">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="184"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="CFEM" evidence="12">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="93"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="341"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="533"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="104"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="147"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="419"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="458"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="480"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="533"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="556"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="577"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="588"/>
            <end position="599"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDM33847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="599" mass="64605" checksum="5F59FBFF8AD1FBCC" modified="2014-04-16" version="1">MVPDCAKDCVDSFIMSEYTFIECTSPSNIKCLCRTKTTSSLTLGEAALSCVLSVCSQTVIAKSKAYHICDSVSEALPKTHQTITATVFSDTSTTKTSDAKTSRETTPTLSTSTTEHTSEASMGTSIATSTSTPTSTTSQTSEITFYAASSSSGSQVEPTSSTGQISSDSSEDTNKKGDHSITPAAIIGMSVASGVAGFFIIGVAVFFCCKRWRRKQREQTAPHIFEIGGAMSEPPDFSKPMPRLPTNGLGLESSYSPTSDRETMEQRPRTFHSMASVQPPRYSPQYAKVHHLGQSKEPTDQERIGFAISSDSDWETSPRTQSSQHSIARLLPDPIAGLYPKPLKWSHRPPSGETLFEEDESQQAAAAATAEMTQNKPPRPGIQPKLAGLPANPRAFKEGFSTDNFKRRSGSPKALAIPSNANPAYKTSSTDSSATPYQVSQTSYSCSNPNILPAAPVKTTQAQPQNRSLSPGRRAPQSCPTLSSSTLPPGSEIVSRPRIVRGNDIKRVQIRNSPRPPSEVVAPYCPDDLWLERGRGLAPPKSREPSGELPYPSDMHPGDVHYPDSPKRKAGAVSKRVSPNSRNLTPSRRGDDLILRVDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>W6QWJ1</accession>
    <name>W6QWJ1_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 14">Saccharopine dehydrogenase [NAD(+), L-lysine-forming]</fullName>
            <shortName evidence="14">SDH</shortName>
            <ecNumber evidence="5 14">1.5.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12 14">Lysine--2-oxoglutarate reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">lysA</name>
        <name evidence="20" type="ORF">PROQFM164_S03g000611</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the NAD(+)-dependent cleavage of saccharopine to L-lysine and 2-oxoglutarate, the final step in the alpha-aminoadipate (AAA) pathway for lysin biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>L-saccharopine + NAD(+) + H2O = L-lysine + 2-oxoglutarate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12440"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:57951"/>
            <dbReference type="EC" id="1.5.1.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-lysine from L-alpha-aminoadipate (fungal route): step 3/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the AlaDH/PNT family.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.7" evidence="5 14"/>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QWJ1"/>
    <dbReference type="STRING" id="1365484.W6QWJ1"/>
    <dbReference type="OMA" id="YFFFSHT"/>
    <dbReference type="OrthoDB" id="265306at2759"/>
    <dbReference type="UniPathway" id="UPA00033">
        <property type="reaction ID" value="UER00034"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004754">
        <property type="term" value="F:saccharopine dehydrogenase (NAD+, L-lysine-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd12188">
        <property type="entry name" value="SDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000217">
        <property type="entry name" value="Saccharopine dehydrogenase [NAD(+), L-lysine-forming]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000627">
        <property type="entry name" value="Saccharopine dehydrogenase [NAD(+), L-lysine-forming]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051168">
        <property type="entry name" value="AASS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007886">
        <property type="entry name" value="AlaDH/PNT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007698">
        <property type="entry name" value="AlaDH/PNT_NAD(H)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027281">
        <property type="entry name" value="Lys1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11133">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11133:SF23">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE [NAD(+), L-LYSINE-FORMING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05222">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018250">
        <property type="entry name" value="Saccharopine_DH_Lys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01002">
        <property type="entry name" value="AlaDh_PNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01003">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10 14" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="9 14 16" id="KW-0520">NAD</keyword>
    <keyword evidence="8 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal" evidence="19">
        <location>
            <begin position="7"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding" evidence="18">
        <location>
            <begin position="174"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="15">
        <location>
            <position position="78"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="15">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="202"/>
            <end position="203"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="320"/>
            <end position="323"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="204"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00021221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00033228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR018250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR018250-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR018250-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR018250-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM01002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM01003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CDM33887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="375" mass="40732" checksum="C71B9A5CA39EDC67" modified="2014-04-16" version="1">MAGQKIWLRAETKPAEARSALTPTTCKALIDAGYDVTVERSTQRIFDDEEFSKVGAPLVEEGSWVQDAPKDAIILGLKELPEDDFPLEHVHVTFAHCFKQQGGWENVLSRWSRGKGTLLDLEFLTDDSGRRVAAFGWSAGYAGSALAVKNWAWQLTHPNEALPGEVHYANQDLLVESVKEALEAGKKVAGKAPKILVIGALGRCGSGAVQLAKDVGIPDSNIIEWDMAETARGGPFKEISHEADIFVNCIYLSAKIPAFVDLESLSAPNRTLSVICDVSADTSNPLNPIPLYNITTTFDKPTVPVSGLEAGGLPLSVISIDHLPSLLPRESSEMFSEALLPSLLTLNDRANARVWKQAEQLFHEKVATLPKSLQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W6QX69</accession>
    <name>W6QX69_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small ribosomal subunit protein bS6m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">MRP17</name>
        <name evidence="8" type="ORF">PROQFM164_S03g000866</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial ribosomal protein bS6 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QX69"/>
    <dbReference type="STRING" id="1365484.W6QX69"/>
    <dbReference type="OMA" id="HQIGDYW"/>
    <dbReference type="OrthoDB" id="10259681at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070181">
        <property type="term" value="F:small ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15465">
        <property type="entry name" value="bS6_mito"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.60:FF:000007">
        <property type="entry name" value="37S ribosomal protein Mrp17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000529">
        <property type="entry name" value="Ribosomal_bS6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035980">
        <property type="entry name" value="Ribosomal_bS6_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014717">
        <property type="entry name" value="Transl_elong_EF1B/ribsomal_bS6"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00166">
        <property type="entry name" value="S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21011">
        <property type="entry name" value="MITOCHONDRIAL 28S RIBOSOMAL PROTEIN S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21011:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN BS6M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01250">
        <property type="entry name" value="Ribosomal_S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54995">
        <property type="entry name" value="Ribosomal protein S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 8" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM34142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="121" mass="13688" checksum="3CFA7329E93621FA" modified="2014-04-16" version="1">MLYELIAIVRPGSLNEVREIARNAGTQVIRSGGVVRGYTNWGAFRLPKVTTKHQARYTEGHHFIMRFDSSGSVQSSIRRTLGLDPRMINFSVVKLGDKLEEIKDIEGKVEWNNVSTITEQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W6QX74</accession>
    <name>W6QX74_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S03</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S03g000871</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
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                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
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            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <sequence length="219" mass="23502" checksum="6B40C43E99EFEFBB" modified="2014-04-16" version="1">MSNATIRSEAAASNPSPQSLNLADRTAPRRQRASSIQSSDSDPTSSSGSSSEDDNESEREDKQHSDQEMNGTEESTTHANASDPSSIPHIAGRPKPRIHRIRGDSGLLSRLNAFLPKMKDANENLQKQIEAGEAGDLVLDNADENAEQYIEMDLGLGVLEEKRDGDSSSDEESDDEGSNGVTGTGETPQEMNDSDIIGKLMGGKSKKLNTDKPSIEEMA</sequence>
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</entry>
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            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
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                <person name="Abraham A.L."/>
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                <person name="Lacoste S."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1038/ncomms3876"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <source>
            <dbReference type="Pfam" id="PF10382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM35972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="638" mass="69093" checksum="DB17BFC57C5ED2B8" modified="2014-04-16" version="1">MMSTPSSSTRPPPTSPQVTASVVKFRCLYTHDLRRKSKRWHDGHLRYHKHNKRVMVYDDQGNFIGDHHWRSTDEVQDGDEMELDKGVLIEVTENMGTTETDITTLYEKKKSSQGSPPARDPRSPSTYTPSASVPLRGSQSFRSLYDLLGIKKTPIGHLISPHEERNPPQPASSLQEPERAPKRQKTSSVVNRGEQRSRVGEVIDLTDSTDSVQGLSERERPKQLKKPHRAGGDSTADAALPVNREQRSKPTRPQRPNPPSFSSASASTASEPISSLPTTEELFRTPAKGFQPARSLGNKSKDNPPPIQPPRPRGPSTSSLPTVTPETEIPRPRETLCVEQPSISRENRSRALSRPIPPQRSDPPAASRSSLTSAPKPSSARSTPQTPVRAVSNYVNPIEPVCNQASINVPASVNIPPPANVPPTVNIPSPANISSSANIPLPANVLPTVNVPSPVNISSSTSMPPPSRSSSTLRSGAPTSSLRMGVGKPRRKLMYSALLPGASRTPSPATSDTSPGSASEPATNTPEQQLAAVPGDSSISNEEFMPSSSTQFIFDEMIDGSGFKSPSTIKSLTGKRSLNSPLRKSMSDPIESTTRQVRAGGPLHAANKENEPREQGPWTSEALDLFDFWPTGRPKPNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2024-10-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>W6R2J8</accession>
    <name>W6R2J8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S04</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S04g000948</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM36067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6R2J8"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM36067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="56" mass="6525" checksum="F86E328923F35372" modified="2014-04-16" version="1">MDLPFTTRLNGEPVYDSTWSHSLHNLDSILRRLTPLALETDRMQTLAQCVPRGDRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W6R2Z4</accession>
    <name>W6R2Z4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Protein pacG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">pacG</name>
        <name evidence="12" type="ORF">PROQFM164_S05g000025</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Transcription factor that acts as a positive regulator of nonrepressible acid phosphatase activity. Is a major regulator of responses to nitrogen and carbon starvation and is essential for the expression of genes involved in vegetative incompatibility (like pin-c, het-6, and tol). Vegetative incompatibility is a non-self-recognition system ubiquitous in filamentous fungi which results in programmed cell death.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6R2Z4"/>
    <dbReference type="STRING" id="1365484.W6R2Z4"/>
    <dbReference type="OMA" id="MRYIMTD"/>
    <dbReference type="OrthoDB" id="4117572at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000228">
        <property type="term" value="C:nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1390:FF:000002">
        <property type="entry name" value="PhoG like DNA-binding family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1390">
        <property type="entry name" value="NDT80 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052605">
        <property type="entry name" value="Fungal_trans_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024061">
        <property type="entry name" value="NDT80_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037141">
        <property type="entry name" value="NDT80_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008967">
        <property type="entry name" value="p53-like_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35144">
        <property type="entry name" value="MEIOSIS-SPECIFIC TRANSCRIPTION FACTOR NDT80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35144:SF1">
        <property type="entry name" value="PROTEIN PACG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05224">
        <property type="entry name" value="NDT80_PhoG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49417">
        <property type="entry name" value="p53-like transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51517">
        <property type="entry name" value="NDT80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="NDT80" evidence="11">
        <location>
            <begin position="81"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="NDT80" evidence="9">
        <location>
            <begin position="81"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="220"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="319"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="222"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="342"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="405"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="422"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00053436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDM36192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="591" mass="64918" checksum="CFC80FCD5C936F0F" modified="2014-04-16" version="1">MEGFDTMAMPPYMASPLSLGNLQSTDYLNAMSGLDLPDHRSNFDSETFVSEDLATFAPPTLAHQLRRFSSAYDDPFTEMVAPFDPAPQEQPQDSSIDHNNKLLSFSLPVYHFTLLDYSMRRTSLSVSAQLHGMFFLAESPYTTSPSENAPPQQGAELTCYRRNLFQITGSVTLPRGMRYIMTDQGDRIPILAQELTVSATESVEGNPVKIISVPWKTPSAAAANSGTAPEENNPSTGAKIEKEPPPIPLDIMAGQDLDSDYATFPIAWKRLQFRVATANNGRRKELQQHFVVRLKVVATLSTGAKISISEVQSGPVIVRGRSPRNFQSRKDLPLSGSAAASRKNQANSSNSAVNRTPTSDSVPRRASVTPAKTKTAAQSSSPETTSVPPPSIMQQSKATPDWTPIPQSTSNNVMSHAPKSMFRQSSPEQLSQATDSHRRVNSTTAAAAPINLSLLDEEESGDHNLHLEQKMVSPFAAELSHQRSLSLDQSVPPSKMRKLSHAVSQTPSRSVASSMPLLETANLPQSFASSLPFPNENDDLLYEYFPLGMDEWQAPVDAVYRPHVVHHTNMPEMKFVARGRNKRYFTAEDVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W6R545</accession>
    <name>W6R545_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S05g000780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6R545"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM36947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="51" mass="5553" checksum="E06BC3F452982516" modified="2014-04-16" version="1">MTISHGHSESKGVSTAPETCPTATQPACNPVTNNVAGSYFQRYLVLFQKWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W6R643</accession>
    <name>W6R643_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S06g000213</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792020">
        <property type="protein sequence ID" value="CDM37252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6R643"/>
    <dbReference type="STRING" id="1365484.W6R643"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM37252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="77" mass="8967" checksum="4AC434749899047B" modified="2014-04-16" version="1">MSQEGLVKRPIDRVMEQFGSKSNKEVFRLLRQSINVIKGDLWSLNPVPGNPLKWPGMVQDEDPRKALTLIRDYRNFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W6R7A6</accession>
    <name>W6R7A6_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Carboxypeptidase</fullName>
            <ecNumber evidence="13">3.4.16.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">cpyA</name>
        <name evidence="16" type="ORF">PROQFM164_S07g000075</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Vacuolar carboxypeptidase involved in degradation of small peptides. Digests preferentially peptides containing an aliphatic or hydrophobic residue in P1' position, as well as methionine, leucine or phenylalanine in P1 position of ester substrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>Release of a C-terminal amino acid with broad specificity.</text>
            <dbReference type="EC" id="3.4.16.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the peptidase S10 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.-" evidence="13"/>
    <dbReference type="EMBL" id="HG792021">
        <property type="protein sequence ID" value="CDM37727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6R7A6"/>
    <dbReference type="STRING" id="1365484.W6R7A6"/>
    <dbReference type="OMA" id="GDWMKPF"/>
    <dbReference type="OrthoDB" id="443318at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000328">
        <property type="term" value="C:fungal-type vacuole lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.410:FF:000001">
        <property type="entry name" value="Carboxypeptidase Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008442">
        <property type="entry name" value="Propeptide_carboxypepY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018202">
        <property type="entry name" value="Ser_caboxypep_ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF113">
        <property type="entry name" value="SERINE CARBOXYPEPTIDASE CTSA-4.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05388">
        <property type="entry name" value="Carbpep_Y_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00131">
        <property type="entry name" value="CARBOXYPEPT_SER_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 13 16" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 13" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0926">Vacuole</keyword>
    <keyword evidence="8" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012519991" description="Carboxypeptidase" evidence="14">
        <location>
            <begin position="16"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="domain" description="Propeptide carboxypeptidase Y" evidence="15">
        <location>
            <begin position="6"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00052076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF05388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CDM37727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="550" mass="61455" checksum="DBBF5E7706D2D79C" modified="2014-04-16" version="1">MRVLSATLLVGAASAAAPPFQQVLGAHREYAENVAQQGADALKPLQHLQDQFKSLSGEARQLWEEVSNYFPESMESAPLLSLPKKHTRRPDSHWDYHVSGAEVQDIWVSNAEGVKEREVEGKLEDYSLRAKKVDPSALGIDPGVKQYSGYLDDNENDKHLFYWFFESRNDPKNDPVILWLNGGPGCSSLTGLFLELGPSSIGADIKPIYNDFSWNNNASVIFLDQPINVGYSYSGSSVSDTVAAGKDVYALLTLFFKQFPEYAVQDFHIAGESYAGHYIPVMASEILSHKKRNINLKSVLIGNGLTDGLTQYEYYRPMACGEGGYPAVLDESTCQSMDNSLARCQSMIQSCYNSESPWVCVPASIYCNNAMLGPYQRTGQNVYDIRGKCEDESNLCYKGMGYVSEYLGQESVREAVGAEVDGYDSCNFDINRNFLFNGDWFKPYHRLVPGLLEQIPVLIYAGDADFICNWLGNKAWSEALEWPGQKEFAAAKLEDLKIVQNEHVGKNIGQIKSHGNFTFMRIFGAGHMVPMDQPEASIDFFNRWLGGEWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>W6R7E8</accession>
    <name>W6R7E8_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Pre-mRNA-splicing factor RSE1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Pre-mRNA-splicing factor rse1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">rse1</name>
        <name evidence="14" type="ORF">PROQFM164_S07g000090</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in pre-mRNA splicing and cell cycle control.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the RSE1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792021">
        <property type="protein sequence ID" value="CDM37742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6R7E8"/>
    <dbReference type="STRING" id="1365484.W6R7E8"/>
    <dbReference type="OMA" id="PRATGHW"/>
    <dbReference type="OrthoDB" id="436637at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001143">
        <property type="entry name" value="Pre-mRNA-splicing factor rse-1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000068">
        <property type="entry name" value="Pre-mRNA-splicing factor rse1, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018846">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058543">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050358">
        <property type="entry name" value="RSE1/DDB1/CFT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004871">
        <property type="entry name" value="RSE1/DDB1/CPSF1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10644">
        <property type="entry name" value="DNA REPAIR/RNA PROCESSING CPSF FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10433">
        <property type="entry name" value="Beta-prop_RSE1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23726">
        <property type="entry name" value="Beta-prop_RSE1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03178">
        <property type="entry name" value="CPSF_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="RSE1/DDB1/CPSF1 first beta-propeller" evidence="12">
        <location>
            <begin position="19"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="RSE1/DDB1/CPSF1 second beta-propeller" evidence="13">
        <location>
            <begin position="461"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="domain" description="RSE1/DDB1/CPSF1 C-terminal" evidence="11">
        <location>
            <begin position="854"/>
            <end position="1175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00040134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00055157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00068521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF10433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF23726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDM37742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="1209" mass="133698" checksum="2967EF8D6797AE6D" modified="2014-04-16" version="1">MATTSHMFMYSLTIQPPTAITQAILGQFAGTRDQQIVTSSGSKLTIHRPDPAQGKITPLFSQDVFGIIRSLAAFRVAGSNKDYIIVGSDSGRITIIEYVPSQNRFNRIHMETFGKSGVRRVVPGQYLAVDPKGRACLIASVEKNKLVYVLNRNSQAELTISSPLEANKPQTLVFAMICLDVGYDNPVFAALEVDYSESDQDPTGEAYEELEKVLVYYELDLGLNHVVRKWSDPVDRTASMLFQVPGGDDGPSGVLVCAEDNITYRHSNQGAFRVPIPRRRGPTENPERKRSIVSGVMHKMRGAFFFLLQTEDGDLFKLNLEMVEDKQGKPTGEVKRLTIKYFDTIPVSTNLLILKSGFLYAASESGNHNFYQFEKLGDDPNEAVFSSDSFSADHSVSSAPIYFRPRGAENVNLMESMNSLSPLIDSKILNLSEDDAPQIYTICGSGARSTFRTLKHALKVSEIVESDLQQVPSAVWTTKLTRADEFHTYIILSFANGTLVLSIGEIVEEVSDTGFLSSAPTLAVQQIGEDSLVQVHPRGIRHILADQRVNEWPVPQHRSIVAAATNERQVAVALSSGEIVYFEMDADGTLAEYDERRQMSGTVTSLSMGEVPEGRMRSSFLAVGCDDSTVRILSLDPDSTLESKSVQALTSAPSALQIMAMADSSSGGTTLYLHIGLYSGVYLRTVLDEVTGELSDTRTRFIGAKPVKLSQVSVKGQTAVLALSTRPWLGYSDVQTKSFMLTPLDYVGLEWGWNFSSEQCVEGMIGIQGRSLRIFTVEKLDNNMLQDSIPLSYTPRRFVKHPDQPLFYVIEADNNVLSPATRQRLIDDSQAQNGEVADLPPVDFGYPRATGHWASCIQIVDPVTTKSVIFTLDLEDNEAAVSLAAVSFSSQDDETFLVVGTAKDMIVSPPSSSCGFIHIYRFQEDGRELEFIHKTQVDEPPLALLGFQGRLLAGVGPILRVYDLGMKQLLRKCQAPVVPKTIVGLQTQGSRIIVSDVRESVTYVVYKYQDNVLIPFADDSIARWTSSTTMVDYETTAGGDKFGNLWLVRCPSKASEESDEDGSGAHLIHEKGYLHGTPHRLELMIHFYAQDIPTSIHKTQLVAGGRDIIVWTGLQGTIGMFVPFVSREDVDFFQLLETQLASQQPPLAGRDHLMYRSYYAPVKGVIDGDLCEMYLLLPNDTKLMIAGELDRSVREIERKISDMRTRVAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W6PST1</accession>
    <name>W6PST1_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF1774-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g000590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PST1"/>
    <dbReference type="STRING" id="1365484.W6PST1"/>
    <dbReference type="OMA" id="IWSILVY"/>
    <dbReference type="OrthoDB" id="3342455at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013920">
        <property type="entry name" value="DUF1774_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37992:SF1">
        <property type="entry name" value="DUF1774-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37992">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08611">
        <property type="entry name" value="DUF1774"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="235"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM26781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="287" mass="32666" checksum="E350DBADCF165CE1" modified="2014-04-16" version="1">MASFNPFARRETHSASSLNTYRVFVPLTWALVVVIGIYHSVHSPDDTKKGKKLWKQANKHNTPFSENTTLTGVFWIFLLLSQLSYVWHLFSKNNVLVVAAANVATHFILNNVFLAAWILLWTRNQFWGAEIILIAHFINQTVTYWRHSGLPVFVHLPAVAGPYAWTLMALFWNGAVAVHSHNLPGRIVANIFIWVILAIGLFSIVPREDYILGYCLSWLTLSLAVRQVAIKIIALQWIFAFTVFAVFLSVSLYLSTTKYTGRDSLFRRVAHPDSVDREREPLLNEGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W6PVJ2</accession>
    <name>W6PVJ2_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g001736</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PVJ2"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM27925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="59" mass="6634" checksum="BCABCE93B587FF3D" modified="2014-04-16" version="1">MIGQVYRNAKRPSLPSTLYSSPDKRTNHTNHQSSSDSMKVVVRFKLAAIPIVGTYVTRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W6PW30</accession>
    <name>W6PW30_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Protein PNS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">pns1</name>
        <name evidence="10" type="ORF">PROQFM164_S01g002249</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 8">Probably involved in transport through the plasma membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8">Cell membrane</location>
            <topology evidence="2 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the CTL (choline transporter-like) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PW30"/>
    <dbReference type="STRING" id="1365484.W6PW30"/>
    <dbReference type="OMA" id="DTIFVAM"/>
    <dbReference type="OrthoDB" id="44736at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007603">
        <property type="entry name" value="Choline_transptr-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12385">
        <property type="entry name" value="CHOLINE TRANSPORTER-LIKE (SLC FAMILY 44)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12385:SF4">
        <property type="entry name" value="PROTEIN PNS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04515">
        <property type="entry name" value="Choline_transpo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="160"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="228"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="337"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="368"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="435"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="471"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="33"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU368066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDM28438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="537" mass="59548" checksum="A8CE3B20497F9330" modified="2014-04-16" version="1">MSGQAASYYNNEGFPQGQPQYPPNSGYEQQHGNYQPPNNAPYQQPAYQQPPSEPKPPQYHQNVPESGYTFDQAFKIEKPKWNDLWAGLLLIAVFLGYAAVSGLTIHKYATNKGFNGGGIYDSSNDFSLDTNTLVLFIFVLVVALVFSWLYFMGARYFTKTFIWATGILNIVFALATGIYYIARKQYGGGIVFLIFGVFAIVCFISWIPRIPFTAFMLQTAMDVARGYGHIFVVSALGGIVTVAFAAWFSVTMVSIYVAYEPDSTGNNPSCTNGGCSRAKVIGLVVYVTFAMYWVSEWIKNTVHTTVAGVYGSWYFFSKSAGGMPKGSTRGAFRRATTYSFGSISFGSLIIAFINMLRQACSVAQRQEAGQGNLVGSIFVWILGSIISLLDWLVTLFNRYAFCHIALYGKAYIPAAKDTWSMMRDRGIDALVQDCLMGPVLTMGSTFVAYVCALLSYLYLQFTNPAYNRDGNFTAVIMAFAFLIGLQVCQVFMTPIGSGVETIFVAMAWDPQVMINDHPDIYYKLVEIYPRVQQAVHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W6PWC7</accession>
    <name>W6PWC7_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidase C78, ubiquitin fold modifier-specific peptidase 1/ 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S01g001907</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PWC7"/>
    <dbReference type="STRING" id="1365484.W6PWC7"/>
    <dbReference type="OMA" id="PFCPFSD"/>
    <dbReference type="OrthoDB" id="288987at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012462">
        <property type="entry name" value="UFSP1/2_DUB_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07910">
        <property type="entry name" value="Peptidase_C78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UFSP1/2/DUB catalytic" evidence="3">
        <location>
            <begin position="237"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="102"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="170"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM28096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="468" mass="51740" checksum="1DB2A26DFFF6C501" modified="2014-04-16" version="1">MSALDENSMADNNTASCPFCTFADSDANFVSQHIEYCHPETGLASSIQDNPQDLAGQNSASLPVSQGGADKYVDCPHGCGETIEIAELSSHLDLHVAEGMDDTGGTPARPTTDVHGDGYFDDEDSLDMLNSHKGGKRGMQRDSSRVNTAKTPRPHSPPRATNANGTKRLGRSELGPHAHEKKMPSWLRKMLEKGGSTSKQTQITSDGKLTRRETVENETDNLIPVLARLCEQDKSVQRALFCSPKVRHICKMRREGGFCGYRNIQMLVSWLQKSRSFGYEHFPNKGPTILELQDMIESAWDMGFNSSGRAETGGIKNTRKFIGTPEAQALFMSLGIPCEARSLSESGNVRAYEALYIDVAEYFRSACSPDDDAKIVQTDLPPIYFQHQGHSMTIVGFEIRDNGSANLLVFDPMFKTSPAMQRLLGTFVKPSDPTRLLKAYRRGTPYLQKYKIFELLKLCTTSPEHEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W6PY79</accession>
    <name>W6PY79_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glutathione hydrolase</fullName>
            <ecNumber evidence="3">2.3.2.2</ecNumber>
            <ecNumber evidence="3">3.4.19.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Gamma-glutamyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PROQFM164_S01g002761</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Gamma-glutamyltransferase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>an N-terminal (5-L-glutamyl)-[peptide] + an alpha-amino acid = 5-L-glutamyl amino acid + an N-terminal L-alpha-aminoacyl-[peptide]</text>
            <dbReference type="Rhea" id="RHEA:23904"/>
            <dbReference type="Rhea" id="RHEA-COMP:9780"/>
            <dbReference type="Rhea" id="RHEA-COMP:9795"/>
            <dbReference type="ChEBI" id="CHEBI:77644"/>
            <dbReference type="ChEBI" id="CHEBI:78597"/>
            <dbReference type="ChEBI" id="CHEBI:78599"/>
            <dbReference type="ChEBI" id="CHEBI:78608"/>
            <dbReference type="EC" id="2.3.2.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>an S-substituted glutathione + H2O = an S-substituted L-cysteinylglycine + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:59468"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="ChEBI" id="CHEBI:143103"/>
            <dbReference type="EC" id="3.4.19.13"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>glutathione + H2O = L-cysteinylglycine + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:28807"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:61694"/>
            <dbReference type="EC" id="3.4.19.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Mycotoxin biosynthesis.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.2" evidence="3"/>
    <dbReference type="EC" id="3.4.19.13" evidence="3"/>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PY79"/>
    <dbReference type="SMR" id="W6PY79"/>
    <dbReference type="STRING" id="1365484.W6PY79"/>
    <dbReference type="OMA" id="GFMLVHL"/>
    <dbReference type="OrthoDB" id="1081007at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036374">
        <property type="term" value="F:glutathione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103068">
        <property type="term" value="F:leukotriene C4 gamma-glutamyl transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006751">
        <property type="term" value="P:glutathione catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.40:FF:000008">
        <property type="entry name" value="Gamma-glutamyltranspeptidase (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043138">
        <property type="entry name" value="GGT_lsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000101">
        <property type="entry name" value="GGT_peptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043137">
        <property type="entry name" value="GGT_ssub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00066">
        <property type="entry name" value="g_glut_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11686">
        <property type="entry name" value="GAMMA GLUTAMYL TRANSPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11686:SF62">
        <property type="entry name" value="GLUTATHIONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01019">
        <property type="entry name" value="G_glu_transpept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01210">
        <property type="entry name" value="GGTRANSPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004881676" description="Glutathione hydrolase" evidence="4">
        <location>
            <begin position="28"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="395"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="413"/>
            <end position="415"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="437"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="465"/>
            <end position="466"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="488"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR600101-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR600101-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU368068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDM28950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="585" mass="62669" checksum="C23C4D606009BA54" modified="2014-04-16" version="1">MLQPIRLGVLAILSLLLIAIHLPTANTFPLEFSERDTNAGHGSHGKIGPGKLGAVASESSICSRHGSDILEKGGNAADALVATQFCIGVVGMYHSGIGGGGFMLVRSAKGDYEFIDFRETAPAAAFEDMYKGNEDASIYGGLASGVPGEVRGLEHLHKKYGSLPWSTVVQPAIHTARHGFPVTEDLVKYMASAVGTGEDFLTKNPTWAIDFAPNGTRLGLGDTITRRRYADTLETIAQRGADALYSGPIAETMINALQSENGTMTLEDLKNYTVAIRDISQINYRGYKITSTSAPSSGSIAMSILKILGTYKDFFTTEQSVNLSTHRLDEAMRFGYGERSNFGDPLFVDGMAKYEKEILEQSTIDDIRSKISDVRTQNVSVYDPAGLESLDTPGTSHIAVADHTGLAISVITTINLLFGSHIMVPETGIIMNNEMNDFSIPGSSNSFGYIPSVSNYVRPGKRPLSSITPAIVERPNGKLFLIAGSAGGSRIITATVQNIIHSIDQGLSAAKALAKPRLHDQLIPNQVSFEYTYDNATVASMKARGHNVTWVAPGQSTAQLIRVLPNGTFDAAGEPRQLNSAGYSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q000</accession>
    <name>W6Q000_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphoribosylglycinamide formyltransferase</fullName>
            <ecNumber evidence="2">2.1.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">5'-phosphoribosylglycinamide transformylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">GAR transformylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">ade5</name>
        <name evidence="11" type="ORF">PROQFM164_S01g001350</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N(1)-(5-phospho-beta-D-ribosyl)glycinamide + (6R)-10-formyltetrahydrofolate = N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide + (6S)-5,6,7,8-tetrahydrofolate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15053"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:143788"/>
            <dbReference type="ChEBI" id="CHEBI:147286"/>
            <dbReference type="ChEBI" id="CHEBI:195366"/>
            <dbReference type="EC" id="2.1.2.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; IMP biosynthesis via de novo pathway; N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide from N(1)-(5-phospho-D-ribosyl)glycinamide (10-formyl THF route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the GART family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.2" evidence="2"/>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q000"/>
    <dbReference type="STRING" id="1365484.W6Q000"/>
    <dbReference type="OMA" id="HYVDEGM"/>
    <dbReference type="OrthoDB" id="5575075at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004644">
        <property type="term" value="F:phosphoribosylglycinamide formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.170:FF:000009">
        <property type="entry name" value="Phosphoribosylglycinamide formyltransferase (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.170">
        <property type="entry name" value="Formyl transferase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01930">
        <property type="entry name" value="PurN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002376">
        <property type="entry name" value="Formyl_transf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036477">
        <property type="entry name" value="Formyl_transf_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004607">
        <property type="entry name" value="GART"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00639">
        <property type="entry name" value="PurN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43369">
        <property type="entry name" value="PHOSPHORIBOSYLGLYCINAMIDE FORMYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43369:SF2">
        <property type="entry name" value="PHOSPHORIBOSYLGLYCINAMIDE FORMYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00551">
        <property type="entry name" value="Formyl_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53328">
        <property type="entry name" value="Formyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Formyl transferase N-terminal" evidence="10">
        <location>
            <begin position="6"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00041324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDM27539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="223" mass="24519" checksum="0B8F7901132BDB4F" modified="2014-04-16" version="1">MTSPIRVTVLISGNGSNLQAVMDKVAAGQINATIVRVISNRKTAFGLERATKANIPTEYHNLVKYKKQHPATPEGIQLAREEYDAELARLILVDAPELVVCLGFMHILSPQFLEPLEAAKIRIINLHPALPGAFNGVNAIGRAHAAWLADQIDKTGVMMHDVISEVDMGTPILVREIPFRKGQDENLETFETRVHEIEWGVVVEGVDKVVKELMAQKEKGSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q0B6</accession>
    <name>W6Q0B6_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Iron/zinc purple acid phosphatase-like C-terminal domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g003538</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q0B6"/>
    <dbReference type="STRING" id="1365484.W6Q0B6"/>
    <dbReference type="OrthoDB" id="45007at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025733">
        <property type="entry name" value="PAPs_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14008">
        <property type="entry name" value="Metallophos_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Purple acid phosphatase C-terminal" evidence="1">
        <location>
            <begin position="47"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM29725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="110" mass="12027" checksum="A9195A26B7D80D64" modified="2014-04-16" version="1">MKPGRATINVASKLGGEDDDIMNPLLGRNGPLDNEVIDPAGLNNPKSPWYITSAAPGHYDGLDSFDTPLKPYAVYGEDTVYEWSKITFHNCTHMTHEFVGTYGLGRSALN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q1I4</accession>
    <name>W6Q1I4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Actin interacting protein 3, C-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PROQFM164_S02g000334</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q1I4"/>
    <dbReference type="STRING" id="1365484.W6Q1I4"/>
    <dbReference type="OMA" id="WSRKQAS"/>
    <dbReference type="OrthoDB" id="783096at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005519">
        <property type="term" value="F:cytoskeletal regulatory protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030010">
        <property type="term" value="P:establishment of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1540">
        <property type="entry name" value="Actin interacting protein 3, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022782">
        <property type="entry name" value="AIP3-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005613">
        <property type="entry name" value="AIP3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056279">
        <property type="entry name" value="Aip3p_Bud6_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051825">
        <property type="entry name" value="SRCIN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22741:SF10">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN CG32809"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22741">
        <property type="entry name" value="P140CAP/SNIP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03915">
        <property type="entry name" value="AIP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23153">
        <property type="entry name" value="Aip3p_Bud6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00806">
        <property type="entry name" value="AIP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Actin interacting protein 3 C-terminal" evidence="4">
        <location>
            <begin position="512"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="170"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="209"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="400"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="957"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="730"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="816"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="17"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="212"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="240"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="257"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="268"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="957"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="971"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="989"/>
            <end position="998"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDM30185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="1043" mass="114347" checksum="D775537CE96BDB86" modified="2014-04-16" version="1">MQSSDVSRAQFPYPEQLVQQASPERPSGSGSADTSMASQQSGRSSSASARSQSSKTQPDKQISQIEKSVTHLLVATKQLLETLTQWSRKQASENDVSDVYVRLGYEFNLACRAFSAIGVDTSDLGPVPDLLRTILEDTLSQDASSQSLDRYLPRIRDIIINLLKGLKKKQARLRSRHQREDGRSAPGRQASAGSIASGQPIGQLYDEAAASTMPSTSQSSPRRSNRRYGSGSLEDPPSIARTSSAPSITEPRTTNYAERELSRREAQQMLSQPTPFDNDTTPRANTSNTTAPSYITPTGFSAPPPPPPPKEDDALGALQRSGELERRASRRFSAYQIQKHLGTSTNGVPVLPTQNSPIPNRGRDVRESLNAVRLRGSFTHTRQRSNNRLQEVAKVAQAPPPANIPNVVEEERTPPPAPPFEPQEIDNTPLEVPNEPDAHKVKDDTVESTIVPPSILPLPQEKPTLEEAFESAKPAPQTPKEDTFELSEIATPLSAIQFATEQPSPGKELTLFLQYKSKIKKYVLPDGIAELTIGRLQLAFIEKFAWNTHDNGVDLPEIYIQDPISGIRHELEDLTDVKDRSVLVLNVDNLDEVKKHFDDGLGSVRLLVEGVKETLAGQGNIIQRVSDRQLEAAKEIARLSAAPPATSSLAAVGGNSKASIVGSGTQIAELQSLRRDLAVLRQTYSNFTSDITGSMSAVRAKASKVKTVASDISTPTYEGDAGRARVNTGKKELAGESERLVARVDDLQDLVEDLRKDVVTRGVRPLPRQLEGVGRDISLVMKEIKKMQDFLAREKPVWTKIWEKELQLVCEERDQLTMQEDLAADLQDDLEKATQTFALVEQATKEQVLTNATGSTAVRAPSRSLGIDPTVDPMKAKDGVLGEVRALQPNHESRLEAIERAEKARKKELETRRIGLFQKELGAFVDEGKLKKSGGFEETERLRTAKDDRIRKEVWDRQQARNAEMEKAEAEAAAVQAAEQAAEQNNEGGGDDDQEEGGNEAKPEDGDEAEEAEEPKSPSSDTDKPLPTAPEEEDKADPEHPST</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q1J2</accession>
    <name>W6Q1J2_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein RSN1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">RSN1</name>
        <name evidence="14" type="ORF">PROQFM164_S01g003634</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CSC1 (TC 1.A.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q1J2"/>
    <dbReference type="OMA" id="PKRYYAH"/>
    <dbReference type="OrthoDB" id="1076608at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005227">
        <property type="term" value="F:calcium-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045122">
        <property type="entry name" value="Csc1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003864">
        <property type="entry name" value="CSC1/OSCA1-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027815">
        <property type="entry name" value="CSC1/OSCA1-like_cyt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032880">
        <property type="entry name" value="CSC1/OSCA1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022257">
        <property type="entry name" value="PHM7_ext"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018:SF53">
        <property type="entry name" value="DUF221 DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018">
        <property type="entry name" value="PROBABLE MEMBRANE PROTEIN DUF221-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14703">
        <property type="entry name" value="PHM7_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12621">
        <property type="entry name" value="PHM7_ext"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02714">
        <property type="entry name" value="RSN1_7TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13967">
        <property type="entry name" value="RSN1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="414"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="463"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="503"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="548"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="589"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="614"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="669"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like N-terminal transmembrane" evidence="12">
        <location>
            <begin position="40"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like cytosolic" evidence="13">
        <location>
            <begin position="211"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like 7TM region" evidence="10">
        <location>
            <begin position="407"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="domain" description="10TM putative phosphate transporter extracellular tail" evidence="11">
        <location>
            <begin position="752"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="323"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF12621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF13967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF14703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDM29821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="866" mass="97714" checksum="C72C4551A5F6D180" modified="2014-04-16" version="1">MSSITDNDTNIGSSRGNASTTSGDIASSLTGEGGSSGSALMMTLLPALVYAIFWVSLFLIFRRTQRRWYAPRSYLPDIHEHQRSPELPSGWVNWLGTFLKIEDNHVLHHSSLDGYLFLRFLRVLAATCLTGCVITWPILLPLHATGGNGNTELDILSFSNVKNPSRYYANAIVACVYFTFVFYVVVRESLYYANLRQAYLNSPAYASRMSSRTVLFMSVPDAYKNQNKLRQVFGDSIRRTWITSDCTKLKKMVSERDRLAEKLETAETKLIRRANKIRTQAIKTGELNIDMCLDCESSNPAWSHKVKRPMHRPKFFGEKVDSIHWYRAQLAKKTEEVANLQAKHQNGEAKQLSAIFVEFNSQADAQVALQTLSHHQPFHMTPRFIGISPREVVWSALNLSWWQRIVRRFAVQGFLAAMVIFWSFPAAIVGAISNITYICRIIPFLSFILDLPDFIKGAIEGLLPAASLAALMSLVPIICRICARRAGVPSRARVELFTQSAHFVFQVVQVFLVTTLTSAASAATAQIVKDPLSVKDLLAQNLPKATNFYISYFMLQGLSMSSLALVQIVSALVFKFVTTFFAYSPRRLFQGWVELASISWGNVFPIFTNMAVIALTYSCIAPLILGFAFLGLYLVYQAYRYNFLFVYDIQVDTKGLVYPRALQHLLTGLYLAEICLIGLCAIKGAIGPVIIMALFMVGNILAHMSLNDALAPLNSFLPRSLDAEEEMLQEKEDEVAAINEERRPRAMAFWKWFHPNVYKDYAALRQKIRRNVEGVSYTPEEMRTAYFEPCVASPPPTLWIPRDKWGFSNHEVLETDPVISITDEGAHLNEKNKIRVRCWWVKHRIHPKGEVHQGKRCAAAGSQTAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q1L9</accession>
    <name>W6Q1L9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S02g000005</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM29856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q1L9"/>
    <dbReference type="STRING" id="1365484.W6Q1L9"/>
    <dbReference type="OMA" id="GSKHECG"/>
    <dbReference type="OrthoDB" id="10251412at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057495">
        <property type="entry name" value="AAA_lid_BCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25426">
        <property type="entry name" value="AAA_lid_BCS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mitochondrial chaperone BCS1-like ATPase lid" evidence="3">
        <location>
            <begin position="118"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM29856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="165" mass="18639" checksum="FB90161B02A068B8" modified="2014-04-16" version="1">MKDFLNEDTQKWYADRGISDSKLIKLFSELPLHCIVLLEDVDAARIGCRDDSDTDQEDKSTSRVTLSSLLNVLNDEALIRPGRADKKVYFQLADKKISTQLFHMVFKQTADHKGSKHECGDKAIERLANNFTSKVPDQVFSPTEVLSFLLEQKNSPFSAVTSVEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q1U4</accession>
    <name>W6Q1U4_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Proteasome subunit alpha type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PROQFM164_S01g001995</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the peptidase T1A family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q1U4"/>
    <dbReference type="STRING" id="1365484.W6Q1U4"/>
    <dbReference type="OMA" id="ATCIGKD"/>
    <dbReference type="OrthoDB" id="431557at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03750">
        <property type="entry name" value="proteasome_alpha_type_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000048">
        <property type="entry name" value="Proteasome subunit alpha type-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 5 6" id="KW-0647">Proteasome</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="8">
        <location>
            <begin position="5"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="143"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="148"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00026071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM28184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="276" mass="29946" checksum="3B95DE264233DB1E" modified="2014-04-16" version="1">MADRYSFSLTTFSPSGKLVQIEYALNAVNQGVTALGIKATNGIVLATEKKSSSPLIDPPSLSKISLITPDIGMVYAGMGPDYRVLVDKARKVSHTGYKRIYNEYPPTRILVQDVARVVQEATQSGGVRPYGVSLLVAGWDEGVEPESEEAKKDDPEEKISSKTGGIQKGGPSLYQVDPSGSYYPWKATAIGKHATSAKTFLEKRYTEGLELEDAIHIALLTLKETIEGEMNGDTIEIGIVGPPADHLLGFKGVEGAQGPRFRKLTKEQIEDYLTNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q1Z6</accession>
    <name>W6Q1Z6_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S02g000454</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q1Z6"/>
    <dbReference type="STRING" id="1365484.W6Q1Z6"/>
    <dbReference type="OMA" id="MGIKGAI"/>
    <dbReference type="OrthoDB" id="5407645at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="264"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="306"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="532"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="309"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="358"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="405"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="532"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM30305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="585" mass="66358" checksum="9ACE279F3463966A" modified="2014-04-16" version="1">MAYYEDRYRDRYARPTSYADPYDEPRGHYRRHERDSYVPRASNDSVEEIQRDYPPGSDYTYERSYDSRRSRRPVYENVRRASSVGAYDAPYRSSGPRRPRHYEDERSRRSRYDSDSSSPSRSPPRNRRRKSFSDQALGAIGLGGAAASSSRGDRGRSRSQSRHHHRSYSRSPSDSRSRHRGGSSKRDKSTQRIAQAARAALTAGAVEAFKQRKEPGEWAGAKGKRVLTAAVAAAGTDGLVDRDPSKHGTRHVLESTLAGLAASHFVGGGSRSRSRSRGRDHSSGGGLKNLAATGALAAAGKEIYDRYSKSHSKSRSRHRGRSDSRGSDEDDRGSHKRSKSVSDYIGQGMAALGLGGEQEERRRDSGDDRKEHREHRREHRDDRERRHRRGHRDDDYSDSDAESDYYNRDSRRGKGSRDVGDSSDEKKQRKKLKRDMLVTGGLASVATIHAAHSVYTSIEKRKERLKQLQEGEITPEEARKRRMTANAKDALSIGLAALGIKGAYGEWKELMEKRKENTHFQEECAERAIKRERRRAHSQGPPSRHHRWPDEIEYAPSTADSRNDHTPLYRDGNPYRVHEAPQISY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q2G6</accession>
    <name>W6Q2G6_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">L-serine ammonia-lyase</fullName>
            <ecNumber evidence="5">4.3.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PROQFM164_S02g000325</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-serine = pyruvate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:19169"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="EC" id="4.3.1.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the serine/threonine dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.17" evidence="5"/>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q2G6"/>
    <dbReference type="STRING" id="1365484.W6Q2G6"/>
    <dbReference type="OMA" id="KCTIFLP"/>
    <dbReference type="OrthoDB" id="7773036at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003941">
        <property type="term" value="F:L-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004794">
        <property type="term" value="F:threonine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006565">
        <property type="term" value="P:L-serine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006567">
        <property type="term" value="P:L-threonine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000040">
        <property type="entry name" value="L-serine dehydratase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050147">
        <property type="entry name" value="Ser/Thr_Dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000634">
        <property type="entry name" value="Ser/Thr_deHydtase_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48078:SF2">
        <property type="entry name" value="CATABOLIC L-SERINE_THREONINE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48078">
        <property type="entry name" value="THREONINE DEHYDRATASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00165">
        <property type="entry name" value="DEHYDRATASE_SER_THR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="11">
        <location>
            <begin position="15"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDM30176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="377" mass="40193" checksum="929D1BBF90AF3C1F" modified="2014-04-16" version="1">MAHSDSEHKLKKPWIETPLIESATFSKAAGCKIFLKLESLQPSGSFKSRGIGNLILTSLSDPSNNGKTLHFFSSSAGNAGLAAVIAARDLGCSCTVVVPVSAKPMMIQKIRAAGASDVIRHGASWFEADSYLRKNFIENEDSKSDPLTRNIYIPPFDHPDIWRGAGTLVDELVKQLPPRHHGKTDTCCPFPADAIVCSVGGGGLLNGIIDGLERHLPVPQPATLPQQAAKKLQILAVETSGADSLAHSLHKGYLHPLPAITSQAITLGALCVAQQTLKNAQSPPPGIKVTSIVGTDADAARGVVRLCDELRLEVELACGISVQVGLDRLREVMTDLTPDSRVVIVVCGGNDVSSEMITGYRQSSRVAGNEKRRESML</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q2L4</accession>
    <name>W6Q2L4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Zinc finger C2H2-type/integrase DNA-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PROQFM164_S02g000714</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q2L4"/>
    <dbReference type="STRING" id="1365484.W6Q2L4"/>
    <dbReference type="OMA" id="ENMSLHG"/>
    <dbReference type="OrthoDB" id="8117402at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000145">
        <property type="entry name" value="Zinc finger protein 574"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050717">
        <property type="entry name" value="C2H2-ZF_Transcription_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14196">
        <property type="entry name" value="ODD-SKIPPED - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14196:SF12">
        <property type="entry name" value="ZINC FINGER PROTEIN 208-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="384"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="414"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="130"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="468"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="613"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="146"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="476"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="509"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="529"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDM30565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="713" mass="79218" checksum="CAD5B31C9F584B14" modified="2014-04-16" version="1">MNSNALGTGRHRRQISTPVAPYQPVMTNMQPHRSHRRGQTVDYNSFSQQPNVDRHMPKTVSQLRDYFNEKSGFSYQPRDVQQYQSYAQQPEQAFIPHGMHMQQPYQYQQQSLGSDCQAFNQEQLQAIHTTTGSPAPSSIGAPALSRSASESSENTPLKRALHRMQQEQFSNQQQQQYVGNADWELYSRRNMPIIQNEQVTAYAGPMHPVSVQPKAPSAKILSQMSTAYSPLTPDSTPLKRSIDYSMYSNVPTPSKSQSFSFPHNPATAEMQRAQSFQGAYVNSVQIKQQMPSPVNSPISTFAEIADMPSPSSYGMTPQNSNISITSSTGRTKKRAPSTVSSPIELAAHDDDLDARVKASVQETGVSTDEIAKFISGPDPKDGKWVCLFTGCLCRFGRKENIKSHVQTHLGDRQFKCDICEKHFVRGHDLKRHLKTHSGNKPFACACGASFARQDALTRHRQRDMCVGGFTGVVPKTTKRGRPPKKKNSRPDLDTRQAKSTRTRQRVAEKSTSNGSAQTHATLQDAPVFNSPNYAPSSAVSSYTPPTSPGDRYHTMSPPCHTYNPVNARLEDDMLPLSPPQLAHARYEQAMAQYASNFSSQTYSQESTYSQESLYSESALSPREMSSPRSAPTLAESSVSSEIDIFMTQDPSEDLRQEFGHLAHSGIPGFPTYQFVDATDFAPVSSYYPEKTFSGIDDLTDPIDCLSSEFLVDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q405</accession>
    <name>W6Q405_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Zn(2)-C6 fungal-type DNA-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PROQFM164_S01g002670</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q405"/>
    <dbReference type="STRING" id="1365484.W6Q405"/>
    <dbReference type="OMA" id="RTFPVCS"/>
    <dbReference type="OrthoDB" id="25921at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
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    </dbReference>
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        <property type="entry name" value="XnlR_reg_dom"/>
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        <property type="entry name" value="Yeast_MetPath_Reg"/>
    </dbReference>
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        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782:SF7">
        <property type="entry name" value="PROTEIN STB5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="38"/>
            <end position="67"/>
        </location>
    </feature>
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            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
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        <location>
            <begin position="114"/>
            <end position="148"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
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            <begin position="137"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDM28859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="649" mass="73350" checksum="914C003C6408113B" modified="2014-04-16" version="1">MEGSIHRFRVHRNSSKPETRRSRGRPADTNGRKPPLPACRRCRQQKKRCTRTDEGSCKPCLVAWLPCSLMERSASPQTRERELQSRIVWLSQLVNETLPAGRSVEDIETGRDIALGTPMQSSSLDASEIEPSESAFEESHTSKAEEDGPISVTAGRKCLQAYFRHVHRTYPFLDSELVLRDFETLANKEADDGLLPRSAVPTRLYMIMAIGFTSLQRAGEVQSIEERDFQPCLKRVLCECVCQVNEQSVGTLLLLGLYLLFVPCDQDPRAITGVLTSHALAVGLMNETPTNQSLSPRVLELRRRLGWSVYVFTRMISISYGLPFAFPDSIMRIPLPSIMIHEYGSEEGHQYAIALQVSRHVISLRRLETRIVNAIYDPHPSMRPQDLRLQIEDWYTQGCLLSSSTLSEQDQLPFHTTITWLNVRYQNLLLLLYTPAQGDTTEENLPSLKAAAQQYIQLSLILHEHRHLPMNWITLCRLLSLAAIFLYCTARWAAFDDIPEIDLLVTLFELFPSSWHAAHEASRILRRLADITTKQKSPLIPRRQLSGSSVMPNSSLDTELGLQSIQDDLAVLLRQTMGEASFYIWPLRSKVTERRVSQSLTMHSFNFLPDSGNFATRVGIGSPADDNMGETAFETHWMNLLGGVGSDML</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q4H6</accession>
    <name>W6Q4H6_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">S-crystallin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S02g001688</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q4H6"/>
    <dbReference type="OMA" id="WKSRYAL"/>
    <dbReference type="OrthoDB" id="4951845at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054416">
        <property type="entry name" value="GST_UstS-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22041">
        <property type="entry name" value="GST_C_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="1">
        <location>
            <begin position="15"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM31538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="277" mass="30036" checksum="803C4B5CBA106E63" modified="2014-04-16" version="1">MSPPTAPMTFYDIALAPPVTKSSCSPNPWKSRYALNFKNVPYKTTWVPLLAISSVRGALNIPASRKFVDGSPYQTLPVLSDPATGRTVGDSLEIAIYLQEQYPSSGAGDLFPAQALEFVFGRDLGLYAPIAEAQVAEGPAAAYAKFNTNVDAVFSAHARLMALGMPFDPAVAEECKAMFSKRMGVPWEALALGGEEREELLRSFEETLGGLAKLYTNDASGPFLMGGKANYADFIVGGWLRMSRGMLPVEEWEALKGWHGGVFGRLHEALEVFAQMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q4R5</accession>
    <name>W6Q4R5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S02g001111</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q4R5"/>
    <dbReference type="OrthoDB" id="10409217at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM30961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="94" mass="10792" checksum="EF95768FA10B3E62" modified="2014-04-16" version="1">MRENRVRRVLGADIADEFEAKMSESQAKRIAMQVVRKLATKTKKDRMGTMKMEIEMEFDGVHGFPDRRASHVARNITGICVHLRPLPPNKRPFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q5H2</accession>
    <name>W6Q5H2_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA polymerase delta subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PROQFM164_S02g001381</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q5H2"/>
    <dbReference type="STRING" id="1365484.W6Q5H2"/>
    <dbReference type="OMA" id="QMLYDFH"/>
    <dbReference type="OrthoDB" id="514823at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043625">
        <property type="term" value="C:delta DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904161">
        <property type="term" value="P:DNA synthesis involved in UV-damage excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006297">
        <property type="term" value="P:nucleotide-excision repair, DNA gap filling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1030.20">
        <property type="entry name" value="DNA polymerase delta, p66 (Cdc27) subunit, wHTH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019038">
        <property type="entry name" value="POLD3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041913">
        <property type="entry name" value="POLD3_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17598">
        <property type="entry name" value="DNA POLYMERASE DELTA SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17598:SF13">
        <property type="entry name" value="DNA POLYMERASE DELTA SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09507">
        <property type="entry name" value="CDC27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="62"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="175"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="394"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="82"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="189"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="240"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="271"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="285"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="307"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="322"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="366"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="410"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDM31231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="434" mass="47715" checksum="A0F23A9F9849B8EF" modified="2014-04-16" version="1">MDSKLYLAENVLNERRLVTYRLLSRALKVHADRAKHILFEFHRNENAKKPKTVHATYVISGIQKAPEPTPTNGHADDEDEMMQSSPYSTGSLPDEDASDSIRTTSIILAREEDLEDAKATFQSISTIHVYSLEATTLPDLNVLVDASREIARTHEQEDPLECGKQWGMIQNRDVRRRTGAHPPPPPAAPSAKAPAGKALKPSTESMVPSKRPLQQEASPAKAEATKLDKPMSEPPSATNSQSSSKPSGKAAPAKQKGNIFSSFAKAKPKTKTPAPAEPATPLAEDASEEEAEELFPDSTDKVAAGTRENRKEREEKLKKMMDDDDDEAADEEMPDADEEPREPTPVEQPPPSKPAELKEEVTIQGGRRRGKRQVMKKKTVKDEEGYLVTREEATWESFSEDEPVPKKKPAVNVPKGKAGKAAGQGNIMSFFGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q5K5</accession>
    <name>W6Q5K5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GTPase effector domain, GED</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S01g003316</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q5K5"/>
    <dbReference type="STRING" id="1365484.W6Q5K5"/>
    <dbReference type="OrthoDB" id="415706at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1240">
        <property type="entry name" value="Dynamin, middle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020850">
        <property type="entry name" value="GED_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51388">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GED" evidence="2">
        <location>
            <begin position="279"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="446"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="469"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="522"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM29504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="618" mass="68035" checksum="983F249B9EF7643E" modified="2014-04-16" version="1">MGTPRTTLQEQRRFLVDISSKFARITDQALNGSYVDEFFGGFQDHTATTKESPFRRLRAVIRELNECFAEAMSIRGNRRIIQFPGQSTPVENVEQERSKPYMSDWTPQYISQESLVDEIKEQARQSRGIELPGSANQLLVGSLFRDQCEPWEAVAKSHLLNTWDSVEYFIQLVLKNLMDDQTRPLLMRHLIGPEMEKMKESLLEKLSELTSYYKRGHPLPVGTSFISKIQESRKNRQIAALKKNLQRSEFAPTGVDTFNVRDLERATSQLQSSSDQFAAAEIIDQMQAYYETAIVTFVDNVAILAIENCLLCPLEHIFTGKTVLEMNDEQIRQIAGEPSNIQKDRERLNEELEKLRKGRQTLNAFVIADSSLRARPILAGPPNPRARTPSRAGTAPIAQVAPNTRLFSRVSPAVTVPAVSSLPVVSLPVASPLPILPSSQGISDTAQGSLFRNPGNGGSLFRDPGNGESLFTGSLNSGSLFTGSLNGGSRPNNGATTTLGSFGLSPGTTSATGNVSSPTVNGTFGSNNQGSNSGSSSAPFGSSTSPTPLWKPLFNATTAPSTLGYKPAYQERERDSNTMNYYQTLGVMLPFSSYSFEELRLGDYARMDKYLSTLPLAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q5W9</accession>
    <name>W6Q5W9_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="2">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PROQFM164_S02g002239</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="2"/>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1365484.W6Q5W9"/>
    <dbReference type="OMA" id="QCILAQD"/>
    <dbReference type="OrthoDB" id="3182339at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022099">
        <property type="entry name" value="DUF3638"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022105">
        <property type="entry name" value="DUF3645"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046541">
        <property type="entry name" value="DUF6606"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051346">
        <property type="entry name" value="OTU_Deubiquitinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13367:SF33">
        <property type="entry name" value="P-LOOP CONTAINING NUCLEOSIDE TRIPHOSPHATE HYDROLASE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13367">
        <property type="entry name" value="UBIQUITIN THIOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12340">
        <property type="entry name" value="DUF3638"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12359">
        <property type="entry name" value="DUF3645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20255">
        <property type="entry name" value="DUF6606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="DUF6606" evidence="9">
        <location>
            <begin position="11"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3638" evidence="7">
        <location>
            <begin position="1992"/>
            <end position="2212"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3645" evidence="8">
        <location>
            <begin position="2331"/>
            <end position="2363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF20255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDM32088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="3082" mass="351691" checksum="CC3392EA8D4C8BF6" modified="2014-04-16" version="1">MDLDHALSTFIFHHIFFPIRLPQEAEHDLVQLESRLIVAVRDVLQDFIQNVSPESQQRWDLALSMLFTWMKLHTEQGILQSGLEEALSNLKFTRAIACHIRAQNCGWVAFYDAEKDRVLVDAFEVSSEDGSILSSSGGLIRRFPGVGVAISADKLSDPTFCSYLATEISQLASEEVPEMLPKSKKAGIEVDEIRNTTHPGLVTEGLMTQLLALGTHHEEKRVLKCVRDEVNWKSALLPWRRSPAWLVIRVALQLVLRRCFNETEGRLHYKNFILYFMATLAARQNPSVASHELVDCYEIMRARIGRRICKLEDKDEVFSFVANRAHSASKDLLDRLMSIKKQIKITNRVRIPLIPSSSSSQDDVHQSLLHCKEYLQAAMRSSPNQVKPTKFCRTHTSNLKWSNDLPIPKIGSIMALSEFEQWVDGHLQSWFINQPASKHEAACRELENTIAQYFSLAKPTYISNPQATSVMILVMLELWVVLDKMALRLCPLMKRFSPGIPDNFLEPLLLPKIGQMKRAREVEQYINVRHKESDKTNPSIFCDPAPNCFGVQFFNSSEEHQMLECRIEQSANAIRAAKQAEWERLSAQYERLHEQEQQMSHYYDYNGDDEYVHLPRDCPRCSLNKQIESISIRVHEWPLPTEDIARKTAVFELSIPIWFASWRNSTWRVLHELGRTLTVTTTDMEVRWLEYTEIQTFVTRRESNIVLASYTKSWRKSHYRSHRFPVSFDSVCIPNALRLRLFDNTRIAWVTIQTNKPSVKSMCTIQLPLGVYSNLQYTLNSTSHSQNQVIATQKDCDKKLSLLEFEAYGCLRSGENLQWGNILRNLASSALSLNEEAVVSLFKQAAWELGPLSGRLGSIRRAAHEAFEDIGFGDCLLHLLRERLVTIENNWNEYCTFDLIVTLGVRILALKSGSPSVEKVVEFLRQCREVAMDWCDQLNQSLLNKEENDDQRQQQLLLLIASTCQATYDVDPMFLDMVIETPRDLFCFVRCSILLFENSPPETDGLSPKIKLSVENSERIRSLSRSRIIWMIMNCASGLNEAIQSGMNCLEVSGLWKTCSDTWVTTETSNSAQGFGQRLHFNYLTGELLVDGNPPGRLPARFANNTLYQRLFGTRVIPVMPSSLPGASFVLSHTVENFEVHFGMQSGKLLIKTRKGSQVLQLIPHEVLEKDFPRVLISENFHWLDLETGAVEFRPLNQPWKPSDRNWHLFFDSNSPGNMLMQQDSKTLVDVQSPPFQKINHILKVLDASDEIVVIRTAVGTLEAELSRLRLKFFVNDNGRVTSKEFGALIDVDQDIGCFYGLKNKLVLVDSSNNRSVIIPYGNPMISREDHHVAVTIDLPTGNRAKYMHYFLDSHLQVLRGFHPLAILYQAYLHAITSFPVPDNLTHRSGTEEAIRILRQECLKSAFPLQNDATETLERIAALTPCRRFYPQHLRVMQTIVWSSNLGQLAQHDDFQSLSQEILQFSEQFSHFHGAKKKENCLLYPGSIDLLKRNRCRAEQIMRSQFSESPTPSRKINYNSRDCNITSARSQNVYRIAALIRDWPTTVGHSSHLLATMRQFKNLATLSADFTRYSCSQMLNQSMESAWVGLYHACQTSSRATHTYFLISLFSILAFGGKIDQSVLRQLLQVAFSEKCKYIPVPLNSTTVLNLSLGGDFVLSQIQYAINTSYTTFTKVYNSHLSRAEQAKINQEAKANWCKQRAEDVRLCGDYIRAQWPSKTPVLPSHALVPLVRRKPAHEMIHMLCRDWVQNRNFLDFLRRVQKEVPPSDPWYHDMDPVPTSPVHFQEIEYSSFQPPCGFDLMHRSHPDPPQTPFAPMTYRGVSSILQSTPELWSLAKHFQASSNQCQQEYGNGLSQSVQALEDFSTSESTPGESDLAASFDWVTNGDAVLRHQEELERQRDTLWDEIVANLRTSANTIWPDTDTVSPSVTVWSVLSILASDKWTSIPIQWKVLLVAFGKSISALRRCERLIACTENRDIDGFLKEAENPGYEGWDPLNYPTWLLLEIENNITIRKRQVEVAARMIKPDCGENAVLQLNMGEGKTSVITPMAAAVLANGHDLLRIIVLKPLLRQSDALLSQRLGGLINRRIYHIPFSRQTELSSPIVSQLQSLYEQCCRQRGILIALPEQMLSFRLIGLDAVERNPNIFSPLIRLENWLQSKCRDVIDESDEVLDVKFQLVYTMGTQQSLDGLSCRWETTQNLLRLVSIQAKRLCQDDPTCIEVDQLGYRFPILRFLKVDAIERLIGYTLKSISENGIPGLPFTQWNSRVKSSVMRFIEHSELAKDDESFIREEFDGSVFMTNLLVLRGLFAYRILRFSLADKRWLVEYGLHPSRCLMAVPYRAKGIPSENSEFGHPDVAVTLTCLSYYYDGLRKEQLRDCFVLLAKENDPSTEFHNWVTQCVDDLPAGLRTYSGVNLEDDKTFTQTLFPILRYQKEIVDFYLSRFVFSREAKEFPRKLSSSAWDIPARRGLQLTTGFSGTNDNRFLLPLSIRQRDLGELLHTNAMVLGLLLREDNRQCILAQDEEGRQLDVDRLLRLVVSTGEGSPTAKPVRVLIDVGAQILEAGNQSVAQKWLAMTPEGDVEAAIFFDQSDETMVIDREGHVETLFSSSFRQRMGACLVFLDQHHSRGVDLKLPLATRAAVTLGPRLTKDRLVQACNRLRGLEKCQSLLFLVPPEVSHNMRSILGISSDRVFTSADVLKWSMAQTCQALDNVRPLWANQGLQYHKKIILWDLIVGQSDPSTKSKTASSIQEPEARTLSQLYAPWDEDRRGRNGHKMPEWNVNNEQVQELLKTLQSTSGHIATSAYLHEEQEREIACEVEREEQISRPPSYEPEDHNLHDDIRYFANFGKFRDKKPSKAVTLAFQGLENTSAGKENHPHLLGPRLYSTVDFNQTVKISKNNVMDDFSKQVNWILSSVHSDVLIIVSQYEANELINIVRKSENVRLNIYTPRLTKPMRSFRHLDFFGVGANIPMQPDDAMTRCLEMFSGSLYFGSFEDYNNFRSFLGLLTDNLGGIPDDAMTNEGFVKYISRRQLQWPIDSPFVENPLPFLGALIHIRTKGMGYQQSHVGTLVKAMPLSAERF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q633</accession>
    <name>W6Q633_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ferric-chelate reductase (NADPH)</fullName>
            <ecNumber evidence="3">1.16.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PROQFM164_S02g002319</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>2 a Fe(II)-siderophore + NADP(+) + H(+) = 2 a Fe(III)-siderophore + NADPH</text>
            <dbReference type="Rhea" id="RHEA:28795"/>
            <dbReference type="Rhea" id="RHEA-COMP:11342"/>
            <dbReference type="Rhea" id="RHEA-COMP:11344"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.16.1.9"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ferric reductase (FRE) family.</text>
    </comment>
    <dbReference type="EC" id="1.16.1.9" evidence="3"/>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q633"/>
    <dbReference type="STRING" id="1365484.W6Q633"/>
    <dbReference type="OMA" id="YMYLYMP"/>
    <dbReference type="OrthoDB" id="4494341at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052851">
        <property type="term" value="F:ferric-chelate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051410">
        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361:SF27">
        <property type="entry name" value="FAD-BINDING FR-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="102"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="216"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="241"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="14">
        <location>
            <begin position="296"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CDM32168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="602" mass="67020" checksum="1A0DF5893C130BFD" modified="2014-04-16" version="1">MGVELKGNGRGEPPMNPTIAVPLFVVGGLIAFLFVWKTVIRISHRRRSKAARQGSDQTQLCRTSRFKAALKRHLLYAPIWGNRHSREFRFLRLHMGSLPLRLEVICLLIYISLNIIFILVTVDWWLSDYSKKMFQLKYAAGHLAVMNTPGLVLGAGRNNPLVQLLGISFDTFNFMHRWVGRVITANAVIHMSAVLADKASTHGTDYVLYVIWQKKLFICGLLAIIGFLFIFVQSLSPARHAFYELFLHLHIALAVFSFVALWYHLQNLLQQRVLLCTLILWGLDRAGRLGILLWRNLSSRPTTATVEVLSGSVARVDVAVARAWRFRPGQYMYLYMPCLGLWTSHPFTVAWSSTGSLNTNEKRGSGGSMDALTGASATTTMSVLIKGQDGFTKKLLQKAEASAEGRIQAMALAEGPFGGIHSLTSYGTLLLIAGGIGITHPMSYLNEVIATFTEQKTATRKVHLVWIVRSLDHLTWIQTFMAEILGHESLSPINSNGHSFFQFPRLLLSISLHITSHKDAVEEYVPQPDSLWMQCAPPGVPVSIHHGKPCMQSVLEKEKEDQIGAMAVSVCGPGGLGDSVREAVRNVQGEKTVDLFEETFSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2024-10-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q710</accession>
    <name>W6Q710_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S02g002301</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q710"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM32150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="66" mass="7002" checksum="7A412FDE35B6F09B" modified="2014-04-16" version="1">MVPPRNAAIGKGKPATVLDRHEEEPVDPETSNPTGVQALVESIEHDDAGEGPFNVRAILDATPNDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q7X1</accession>
    <name>W6Q7X1_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PROQFM164_S02g002641</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q7X1"/>
    <dbReference type="STRING" id="1365484.W6Q7X1"/>
    <dbReference type="OMA" id="AMHQYKV"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032889">
        <property type="term" value="P:regulation of vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006624">
        <property type="term" value="P:vacuolar protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000550">
        <property type="entry name" value="Serine/threonine kinase 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000374">
        <property type="entry name" value="Serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000728">
        <property type="entry name" value="Serine/threonine protein kinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052239">
        <property type="entry name" value="Ser/Thr-specific_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45998">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45998:SF2">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="32"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="172"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="355"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="210"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="233"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="365"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDM32490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="425" mass="47114" checksum="4B36E74292E0B15C" modified="2014-04-16" version="1">MAQYFFDLLYNFTDCMCCFPSSPQLKINNRSFKLLRLLGEGGFSYVYLVQDKASSELFALKKIRCPFGQESVSQALKEVEAYNLFNSQSNIIHSIDHCVSTESGSKFRSDGGDPGSKTVYILLPYYQRGNLQNAINANLVNHTKFPEKRLMVLILGVADALRSMHQYRVKNGAASTRKVKAVRREGEEADDERTMQMKPKRRASHRVPENEDEENEPLMDDEVTRSQEGVEDGDLRPYAHRDVKPGNIMIDDNGQSPILMDLGSLAPSPIAITSRSLALAVQDTAAEHSTMPYRAPELFDVKTGSIIDTKVDIWSLGCTLYACLVGKSPFEARSEETGGSLSMCVLGGDWRFPDEKSGASKGKAKSGESEDASKNEVPAISAPVKDIVRRCLTVEPSERPDIDELIELMKSVIDQMPEDDAGPSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q875</accession>
    <name>W6Q875_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Probable transposable element</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S02g003059</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q875"/>
    <dbReference type="STRING" id="1365484.W6Q875"/>
    <dbReference type="OMA" id="GKRSCKN"/>
    <dbReference type="OrthoDB" id="4362974at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM32908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="115" mass="12835" checksum="F097D732067D6383" modified="2014-04-16" version="1">MQTITAKSTADWYALDQPPRDAMWLSKVADSLGLPRPDLTVIFTDNINSQLLLTKKGGKSATRWLALRYFLVKDAVAQGHVNILRVDTKQNLADGFTKALAMEQFQNFVRLLGIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q8Q0</accession>
    <name>W6Q8Q0_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Beta-lactamase/transpeptidase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PROQFM164_S02g000759</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S12 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q8Q0"/>
    <dbReference type="STRING" id="1365484.W6Q8Q0"/>
    <dbReference type="OMA" id="TGYTWKR"/>
    <dbReference type="OrthoDB" id="5946976at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.600">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050491">
        <property type="entry name" value="AmpC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021860">
        <property type="entry name" value="Peptidase_S12_Pab87-rel_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46825:SF9">
        <property type="entry name" value="BETA-LACTAMASE-RELATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46825">
        <property type="entry name" value="D-ALANYL-D-ALANINE-CARBOXYPEPTIDASE/ENDOPEPTIDASE AMPH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11954">
        <property type="entry name" value="DUF3471"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase-related" evidence="3">
        <location>
            <begin position="9"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S12 Pab87-related C-terminal" evidence="4">
        <location>
            <begin position="430"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="364"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="372"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="404"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF11954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDM30609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="554" mass="61729" checksum="528D1249713E9D3C" modified="2014-04-16" version="1">MDLLHSAGFASHVTELIDQQHVPGLAIAIIHNDQIASAGYGHVSLDPEIPCTADTLFDIASSAKSLTAAAVGLLVADNDMFPDIQYDAVMSTLLPEDFVMSGKGYTEGVSVEDILSHRSGMPSHNDSYMSVRAAKPDNARSITRNLRNLPVAAPIRSKYIYCNMMYTVATHLVEVKSGQNFGTFLEERFFKPLDMASTTLQPSSARSKGFESRMATGYTWKRADSTYRGLENPDCPEGQGAGSVISSVNDFIKFVKAFMNREDPINKNVYEGLTRLRTFVNPNPGRRKRHTSPVAYAAGLDIYFYRGHMVVGHNGVFSGFGSRFFFLPDFSFGAVIMGNSDGANGVAATLVRKLIDNLLGVMDERPHDSKSKATRPVKIRGPKPQAEVKDANPMSKNQGKKEKKKQEKKTQVKKSQDIQKGQVNEQRPKRHTPQPPTMPLSAYAGNYWNPGYHNLLVQIRDDALFIDATDRSMGFTLKFEHVSDDRKFDAHLTDWLDGSDGIVKAEFVIEDAQVTRLGLQLEEMLKEMIWFEQKDGVKSEYLELRLTRNNNLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q9A4</accession>
    <name>W6Q9A4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S02g002747</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q9A4"/>
    <dbReference type="OrthoDB" id="10416970at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM32596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="105" mass="11650" checksum="09A0C9B07B967A58" modified="2014-04-16" version="1">MGIGVGLSCSVPSPALYAIAVAPYLYGYVAGMEHFLETVVACEKGYHSRPLLQSAALVTVHRDGHVLANRLSTAVSRKVDKCWVKFWVAYGTLMRVMCYDLLLWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q9P7</accession>
    <name>W6Q9P7_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Uridylate kinase</fullName>
            <shortName evidence="9">UK</shortName>
            <ecNumber evidence="9">2.7.4.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ATP:UMP phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Deoxycytidylate kinase</fullName>
            <shortName evidence="9">CK</shortName>
            <shortName evidence="9">dCMP kinase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Uridine monophosphate kinase</fullName>
            <shortName evidence="9">UMP kinase</shortName>
            <shortName evidence="9">UMPK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">URA6</name>
        <name evidence="11" type="ORF">PROQFM164_S02g001064</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and dUMP as phosphate acceptors, but can also use CMP, dCMP and AMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>UMP + ATP = UDP + ADP</text>
            <dbReference type="Rhea" id="RHEA:24400"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.14"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="9">Binds 1 Mg(2+) ion per monomer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
        <text evidence="9">Predominantly cytoplasmic.</text>
    </comment>
    <comment type="domain">
        <text evidence="9">Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the adenylate kinase family. UMP-CMP kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.14" evidence="9"/>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q9P7"/>
    <dbReference type="STRING" id="1365484.W6Q9P7"/>
    <dbReference type="OMA" id="EQTMPVI"/>
    <dbReference type="OrthoDB" id="442176at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033862">
        <property type="term" value="F:UMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006221">
        <property type="term" value="P:pyrimidine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01428">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000315">
        <property type="entry name" value="Adenylate kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00235">
        <property type="entry name" value="Adenylate_kinase_Adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03172">
        <property type="entry name" value="Adenylate_kinase_UMP_CMP_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033690">
        <property type="entry name" value="Adenylat_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006266">
        <property type="entry name" value="UMP_CMP_kinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01359">
        <property type="entry name" value="UMP_CMP_kin_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="NUCLEOTIDE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00406">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00094">
        <property type="entry name" value="ADENYLTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00113">
        <property type="entry name" value="ADENYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6 9" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9 10" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="NMPbind" evidence="9">
        <location>
            <begin position="41"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="LID" evidence="9">
        <location>
            <begin position="142"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="21"/>
            <end position="26"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>a ribonucleoside 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="69"/>
            <end position="71"/>
        </location>
        <ligand>
            <name>a ribonucleoside 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="105"/>
            <end position="108"/>
        </location>
        <ligand>
            <name>a ribonucleoside 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>a ribonucleoside 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>a ribonucleoside 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>a ribonucleoside 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDM30914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="209" mass="22947" checksum="38C1ADD253475CB0" modified="2014-04-16" version="1">MATPRFSTNDVTVVFFLGGPGSGKGTQSANLVKDYGFVHLSAGDLLRAEQVREGSQYGDLIREYIREGKIVPMQVTVALLSNAMADSLATSPPPAGTKARFLVDGFPRKLDQAVFFEETVCPSELVLFLDCPEDVMEARLLKRGETSGRDDDNAASIRKRFHTFVETSMPVVDDFEKKNKVVSVKADSSVEQVYEQVKAGIEARGLHTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W6QA31</accession>
    <name>W6QA31_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cytochrome b5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PROQFM164_S03g000247</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QA31"/>
    <dbReference type="STRING" id="1365484.W6QA31"/>
    <dbReference type="OMA" id="GECMVGI"/>
    <dbReference type="OrthoDB" id="432299at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004128">
        <property type="term" value="F:cytochrome-b5 reductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000001">
        <property type="entry name" value="Cytochrome b5 reductase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051872">
        <property type="entry name" value="Cytochrome_b5/Flavoprotein_Rdt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46237:SF1">
        <property type="entry name" value="CYTOCHROME B5 REDUCTASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46237">
        <property type="entry name" value="CYTOCHROME B5 REDUCTASE 4 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="5">
        <location>
            <begin position="277"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="28"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="71"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="92"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="117"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="161"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="214"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDM33523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="360" mass="38086" checksum="6D93F3E67D8E9BB1" modified="2014-04-16" version="1">MGWVAVGVLIATTGYFLYRYPPRSWVEPRSFASPEPKPDAPVAATASEPVQRKHGPRASTPSIETEEEDSQSTPKASASSVPLPVLAVPTFSLDSGGSETSQAAAMPSIPQTVNGTAEERPSTNHEAPKFKPPPQPSLAPPPKPQPSIPPRATTTGTSSLMPPPPVPRPRPATQANRLAPTSTLQPPRLSGNSLGPPPSAAASQRGLGAPRSGSRLSSSTLAPTQVSLKKSSSRKVVLEPGFSPLDWAALAANPKNKLRGEGLPPGLLRVTPSMLKEQHGRKGRDAWTSYHGKVYNISPYAPYHPGGKGELLRGAGKDSAQLFQEIHPWVNWEGILGECLVGILVSEHDIQTENALDAMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W6QA46</accession>
    <name>W6QA46_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EF-hand-like domain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S02g001199</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QA46"/>
    <dbReference type="STRING" id="1365484.W6QA46"/>
    <dbReference type="OMA" id="FHDVMTR"/>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM31049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="193" mass="20794" checksum="D67A823F5000780A" modified="2014-04-16" version="1">MPPKKRGDAASSSAPAAPKRGRASKLAKENNITGEEENEIKEVFHLFSDKNADFPDEKEGVIPREDVRKALVALGLPPTDSTELAEILSALDPTLTGYVPYSPFVSIAAAKLRSRDDDAMAAEVDDAYQLFTRGTNGPITLSHLRRIARELKEDSVGDDILKDMILEGNGGAGLSAGVTLEQFHDVMTRAGVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W6QAH0</accession>
    <name>W6QAH0_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Aminopeptidase</fullName>
            <ecNumber evidence="11">3.4.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">APE2</name>
        <name evidence="16" type="ORF">PROQFM164_S03g000397</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">FM164</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9 11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9 11">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the peptidase M1 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.-" evidence="11"/>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QAH0"/>
    <dbReference type="STRING" id="1365484.W6QAH0"/>
    <dbReference type="MEROPS" id="M01.007"/>
    <dbReference type="OMA" id="MMEYVAI"/>
    <dbReference type="OrthoDB" id="10031169at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09601">
        <property type="entry name" value="M1_APN-Q_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.390.10:FF:000001">
        <property type="entry name" value="Aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.50.20:FF:000002">
        <property type="entry name" value="Aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1730:FF:000002">
        <property type="entry name" value="Aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1910:FF:000004">
        <property type="entry name" value="Aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="entry name" value="tricorn interacting facor f3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024571">
        <property type="entry name" value="ERAP1-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034016">
        <property type="entry name" value="M1_APN-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050344">
        <property type="entry name" value="Peptidase_M1_aminopeptidases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533">
        <property type="entry name" value="PROTEASE M1 ZINC METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533:SF174">
        <property type="entry name" value="PUROMYCIN-SENSITIVE AMINOPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11838">
        <property type="entry name" value="ERAP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="Leukotriene A4 hydrolase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 11 16" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 9 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3 11" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Aminopeptidase N-like N-terminal" evidence="15">
        <location>
            <begin position="88"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M1 membrane alanine aminopeptidase" evidence="13">
        <location>
            <begin position="308"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="domain" description="ERAP1-like C-terminal" evidence="14">
        <location>
            <begin position="599"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="381"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="380"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="384"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="403"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="10">
        <location>
            <position position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU364040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF11838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CDM33673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="943" mass="105784" checksum="BF4DD83F431FADC1" modified="2014-04-16" version="1">MRRFSTRVLLQQAKPPLLSARSPLPLFVSARSPQASIPRSITQRRSPSPLSQTAKRYCSYRRMCSSRRETSGSTNVKGGREVLPTNVKPQHYDLTLEPDFEKFTYEGAVTIDLDVTEDTDFITLNSNQIEIHSAIVSSKGSVVDSKPEISFNEDDQTATIKFGQAIAAGSDAQLKLTFTGILNDNMAGFYRSSYKENGETKYIASSQMEPTDARRAFPCFDEPALKAKFTVTLVADKSLTCLSNMDVDTETEVQGGAKKAVKFTTSPLMSTYLVAFIVGKLNHIETKNFRVPIRVYATPDQDIEHGRFSLELAAKTLAFYEKAFDSDFPLPKMDMVAVPDFSAGAMENWGLITYRIVDVLLDEKNSGASRKERIAETVQHELAHQWFGNLVTMDFWDGLWLNEGFATWMSWYSCNAFYPEWKVWQTYVIDNLQSALSLDSLRSSHPIEVPVKRADEINQIFDAISYSKGSAVLRMISKYLGEDVFLQGVRNYIKKHAYGNTETGDLWSALADASGKPVQSVMDIWTKNVGFPVLSVTENKETSSIHVKQNRFLRTGDVRPEEDQTLFPVMLGLRTDKGIDEDTMLTERERDFPVPDLDFFKLNADHSAIFRTSYSPERLKKLGQAARDGRLSVEDRAGMIADSGALAASGFQRTSGMLSLLQGLDTESEFVVWNEILTRIGTLRAAWLFEDDKTKDALKAFQRSLVAPKAHEIGWEFPENDDHILQQFKALMFGSAGMAEDPTVVKAALDMFTRFAAGDLSAIHPNIRGSVFTIALKHGGLKEYEVVLDRSRHAQTSDEKVTALRCLGASEDPELIQRTLGLAMSEEVKSQDIYMPLGGLRSHPAGVDSRWNWLKSNWDEIYKRLPPGLGMLGTVVQLTTASFCTEAQLKDVEQFFASKDTKGFDRAVEQSLDSIRAKINWLKRDRDDVEQWLSSNSYLQSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W6QAJ3</accession>
    <name>W6QAJ3_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S03</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S03g000169</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QAJ3"/>
    <dbReference type="STRING" id="1365484.W6QAJ3"/>
    <dbReference type="OMA" id="TVRYHSQ"/>
    <dbReference type="OrthoDB" id="5369511at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM33445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="368" mass="41758" checksum="3BEFB7C4B1C63F86" modified="2014-04-16" version="1">MLPVLPHPLAAGPGYPFSASLGSCASSINSKFDTRSLHSSTMAQHPMYGNPATTPLVYQQSGERSPSTPHGYGYRDDRQVPFGPMDSNRQAHYHGGPVLPDGHNLMMSPPAARLSYPPAGPVHVQPRTHEWSHPNQMPRESPRRDLGTMSAPETPEYIMERNSQRTGERSRGSPHYHSQRRTSNRDEFDGPHQFLEPPSPQAVAAQDKELPQLPTNLDAGEQDSILHKVNDRLSQCAYDFIAKYQFRVPIEQDKRPVKVPSDREWTEWVYLLKRLATTRRIPAHLLYNRQIKQLITVLENSLEMRHAAKHQSRPVKDDRNVLQLISAGTQVAKILRDSSAMQYLDSLYVDTEKLILDRRGRRVRFANT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W6QAK7</accession>
    <name>W6QAK7_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">GPI ethanolamine phosphate transferase 1</fullName>
            <ecNumber evidence="14">2.-.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">mcd4</name>
        <name evidence="18" type="ORF">PROQFM164_S01g000561</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13 14">Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the first alpha-1,4-linked mannose of the glycosylphosphatidylinositol precursor of GPI-anchor.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Endoplasmic reticulum membrane</location>
            <topology evidence="1 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the PIGG/PIGN/PIGO family. PIGN subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.-.-.-" evidence="14"/>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QAK7"/>
    <dbReference type="STRING" id="1365484.W6QAK7"/>
    <dbReference type="OMA" id="QSYFHRE"/>
    <dbReference type="OrthoDB" id="2748310at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051377">
        <property type="term" value="F:mannose-ethanolamine phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16020">
        <property type="entry name" value="GPI_EPT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.720.10:FF:000015">
        <property type="entry name" value="GPI ethanolamine phosphate transferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007070">
        <property type="entry name" value="GPI_EtnP_transferase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017852">
        <property type="entry name" value="GPI_EtnP_transferase_1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037671">
        <property type="entry name" value="PIGN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12250:SF0">
        <property type="entry name" value="GPI ETHANOLAMINE PHOSPHATE TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12250">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL GLYCAN, CLASS N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04987">
        <property type="entry name" value="PigN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="8 14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 14" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14 18" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="463"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="501"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="563"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="590"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="617"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="643"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="682"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="714"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="745"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="825"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="864"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="899"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="930"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase N-terminal" evidence="16">
        <location>
            <begin position="172"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="GPI ethanolamine phosphate transferase 1 C-terminal" evidence="17">
        <location>
            <begin position="452"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="980"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="980"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="999"/>
            <end position="1011"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU367138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF04987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CDM26752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="1017" mass="113181" checksum="A8D9F7DEAC0031CD" modified="2014-04-16" version="1">MARLGRVGFLALAVVFHLIYTYSIFDIYFVSPIVSGMRSYGVERLPGASAPAKRLVLFVADGLRADKAFQAFPDPSPDADPENNELIRLSPFIRSKVLSHGTFGVSHTRVPTESRPGHVALIAGLYEDVSSVTTGWKMNPVNFDSVFNQSRHTWSWGSPDILPMFKEGAVPGRVDAEMYSEEAEDFTVDATHLDTWVFSKVHDLFESAKTDPELDRKLRDDKLVFFLHLLGLDTTGHSFRPYSNEYLHNIKVVDQGVQAVTKLVEDFYGDDKTAFVFTADHGMSDTGSHGDGHPDNTRTPLVVWGSGVAQPQLSTSGIAAGHEDGFSADWGFDQVRRHDVAQADVAALMAYLVGLDFPVNSVGQLPLDYLNASPEEKALAALANTQAVLEMYRVKEEQKRHAVIRYVPYDPLAGYHENSIEGRLARIEVLISSGDHEEAIVVSAELLRVALEGLRYLQTYDWLFLRTIVSIGYLGWIAYALTTVIDLHVLHGTSDSHRTTASISFFSSILVALFSVFLYQGSSWRYYFYAFFPVYFWEEVFARRKALIAGRQIVLGHVRSFTGYLKFGLQLLVFLGVMEAMVQSYFHREIFTVCFALGALWPVIHGFSFIRSHPLLSATWSLGCGLMSSFTLLPVIKVENLDTITYGGLLMFLTGILYLLFEDAILGHRDTESKEPNAIGRVGSRIIMGIQLGMVLLAVIVTRSSVLSLQARQGLPFGNIVVGWVVLVTSLTLPFFHRLYPNSHYLHRLMIIFLTFSPTFIILTISWEGLFYFVFCMTIVTWVRLEHAIYVHTTGALKKANNPGVTTVNGETFYYRALTLSDVRVALFFFFLLQSAFFSTGNVASISTFSLDSVRRLIPVFDPFAQGALLILQILIPFAIISANLGILNRRLEVPPSALFMVVMAISDIMTLNFFFMVRDEGSWLDIGMTISHFCIASALCTFVAGLEFLSEQFVSGVDFAPTTAVGDAVIHTIEEITECGHEDHKEPKKPQSNGAKQSKFKGKGKGKGKSGKNGWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W6QAT9</accession>
    <name>W6QAT9_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF3533 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S02g003308</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM33156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QAT9"/>
    <dbReference type="STRING" id="1365484.W6QAT9"/>
    <dbReference type="OMA" id="EFFYLGY"/>
    <dbReference type="OrthoDB" id="2140105at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022703">
        <property type="entry name" value="DUF3533"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053001">
        <property type="entry name" value="MNNG_permease-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34814:SF2">
        <property type="entry name" value="DUF3533 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34814">
        <property type="entry name" value="NITROSOGUANIDINE RESISTANCE PROTEIN SNG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12051">
        <property type="entry name" value="DUF3533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="224"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="265"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="301"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="329"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="384"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3533" evidence="3">
        <location>
            <begin position="33"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="440"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="446"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="483"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM33156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="512" mass="56878" checksum="CF1243BA12620587" modified="2014-04-16" version="1">MQFYPRAREQRPSIHHPSVRPRRFGLLKASAINLLLLQILFLGLFCYLFGSLFQQSSHIHNINVLFVDYDGGAISDAARAAFQSLKGPSFPTLVERSASAYPQPGSIEGAVCDIKYWGALYTTANASNALSAALAGGAAASSYDKNNVLTMVWNEARYPTVIDTVLADSMKVLSETARLAYSQTNGKQSLQSVNSSDPAAIAAFYDPWTLADNNIQPTEQGSRVVYNTLVIILIVIQEFFFLGTINGLYVQFKLYTSLSAHRIAIARLVISSIYTLVGSICTAGAIWAFKSGWSVNGNQFALNWLALWLFAHVNFLVLDTFTIWLPPPYVPMALISRVVSNVTSILLPFELAPAFYKLGFALPAHSVFQVLIDIWSSGCNPQLYFALPILFVYEILGITSSSIGVYRRAHYACIEQEIEEKACKERVTAAILEKEEAQRVRRQASRHAERSGTSDSEDERRAALERRDTVTSPSEQEELTNIIHREMTRPDIDRTSSRKDSTGPSFPLAYRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>W6QBB7</accession>
    <name>W6QBB7_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Aspartate--tRNA ligase, cytoplasmic</fullName>
            <ecNumber evidence="3">6.1.1.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Aspartyl-tRNA synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Probable aspartate--tRNA ligase, cytoplasmic</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">dps1</name>
        <name evidence="16" type="ORF">PROQFM164_S03g000722</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>tRNA(Asp) + L-aspartate + ATP = L-aspartyl-tRNA(Asp) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19649"/>
            <dbReference type="Rhea" id="RHEA-COMP:9660"/>
            <dbReference type="Rhea" id="RHEA-COMP:9678"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78516"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.12" evidence="3"/>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QBB7"/>
    <dbReference type="STRING" id="1365484.W6QBB7"/>
    <dbReference type="OMA" id="WVHEIRD"/>
    <dbReference type="OrthoDB" id="372395at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017101">
        <property type="term" value="C:aminoacyl-tRNA synthetase multienzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004815">
        <property type="term" value="F:aspartate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006422">
        <property type="term" value="P:aspartyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04320">
        <property type="entry name" value="AspRS_cyto_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00776">
        <property type="entry name" value="AsxRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000038">
        <property type="entry name" value="Aspartate--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000132">
        <property type="entry name" value="Aspartyl-tRNA synthetase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02075">
        <property type="entry name" value="Asp_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004523">
        <property type="entry name" value="Asp-tRNA_synthase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00458">
        <property type="entry name" value="aspS_nondisc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003483">
        <property type="entry name" value="PRK05159.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43450:SF1">
        <property type="entry name" value="ASPARTATE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43450">
        <property type="entry name" value="ASPARTYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 16" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="15">
        <location>
            <begin position="244"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="37"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="49"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00070516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CDM33998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="556" mass="62014" checksum="E19CF5F04FE10735" modified="2014-04-16" version="1">MADSELPHRPKPEAQDASAPAAEGETKNASKNALKKAAKDKAKAEKAAARAAQEKAQAAAQEANDTAKDLYGPLPEAENAIPSTRFSELSEEHYEKEVTVVARVDNARVQSAKLAFLMLRQQGQKVQAVIAAAEPISRQMIKYTGGLNVNSIVQITGIVKKPEIPISSASISHLEIHIRKVYMISEAAQMLPMQVKDAERPPPESIDEGAQVDAEGAPIVTLKTRLDNRVLDLQTETSQAITWISSGVSQLFAEYMIKSGSRWISTPKLVGAATEGGSGVFEVKYFKRNAYLAQSPQLYKQMCIAGDMENVFEIAPVFRAEDSNTHRHLTEFSGLDFEKTFRGHYHEVLEFAEDLLVFILTQLKERYATQIATIQKSYPKAGDFKLPKDGKALRLNYMDGVALLKEAGVDVSEQERFENDFSTAMEKQLGQIIREKYDTDFYVLDKFPMAVRPFYTKADPDDKRFSNSYDFFMRGEEIMSGAQRINDIKELEESMRSKGLEPNQEGFEDYLNAFRQGCPPHAGGGLGLNRIVMFFLGLPNVRLASLFPRDPQRLRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W6QBM0</accession>
    <name>W6QBM0_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S03</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S03g000832</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QBM0"/>
    <dbReference type="OMA" id="GWVGYQI"/>
    <dbReference type="OrthoDB" id="4083871at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42077">
        <property type="entry name" value="YALI0F30239P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42077:SF1">
        <property type="entry name" value="YALI0F30239P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM34108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="107" mass="12216" checksum="EAC11DBB5D2AE1FE" modified="2014-04-16" version="1">MGARNIIPLILLLVFVGIIAAVGFVVYSIMQDVGKNTREKMERKNIAFTKDGMKVQVREVKDEAYKDQTQSVLFNMWNHTSFPAYKSRLWDMAGSSSSEQKVAEKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W6QC87</accession>
    <name>W6QC87_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD(P)-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S02g001925</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QC87"/>
    <dbReference type="STRING" id="1365484.W6QC87"/>
    <dbReference type="OMA" id="VIMADYH"/>
    <dbReference type="OrthoDB" id="3535423at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14097:SF8">
        <property type="entry name" value="NAD(P)-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14097">
        <property type="entry name" value="OXIDOREDUCTASE HTATIP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="1">
        <location>
            <begin position="7"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM31774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="150" mass="16704" checksum="2C5292C82FADC827" modified="2014-04-16" version="1">MKLILAGATGLLGTEIIKQSLQIREITQVVALAHQPVQLDKSIDSSKLKIIVLCDYGDYPEDVKAEFANADACIWAVSVTPLRTSKAELNRVFHDCTKLGFEAMYEAGPARPFRFMYLSADGIFRDPTKKAVIMADYHMIRVMDSNPRAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2024-10-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>W6QCM2</accession>
    <name>W6QCM2_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S01g001168</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QCM2"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM27357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="58" mass="6507" checksum="FB061011DF5E513C" modified="2014-04-16" version="1">MDVFVAVFRCARETALSVGGDNVINDSARFSEHDLVFCEGRAVVFDHRRSAGRMQVFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W6QCS7</accession>
    <name>W6QCS7_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pyruvate decarboxylase</fullName>
            <ecNumber evidence="4">4.1.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">pdcA</name>
        <name evidence="16" type="ORF">PROQFM164_S03g000590</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2-oxocarboxylate + H(+) = an aldehyde + CO2</text>
            <dbReference type="Rhea" id="RHEA:11628"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:35179"/>
            <dbReference type="EC" id="4.1.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11">Binds 1 Mg(2+) per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the TPP enzyme family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.1" evidence="4"/>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QCS7"/>
    <dbReference type="STRING" id="1365484.W6QCS7"/>
    <dbReference type="OMA" id="AQEISVM"/>
    <dbReference type="OrthoDB" id="3970464at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004737">
        <property type="term" value="F:pyruvate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000949">
        <property type="term" value="P:aromatic amino acid family catabolic process to alcohol via Ehrlich pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02005">
        <property type="entry name" value="TPP_PDC_IPDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07038">
        <property type="entry name" value="TPP_PYR_PDC_IPDC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000019">
        <property type="entry name" value="Pyruvate decarboxylase isozyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000024">
        <property type="entry name" value="Pyruvate decarboxylase isozyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012110">
        <property type="entry name" value="PDC/IPDC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme_TPP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047214">
        <property type="entry name" value="TPP_PDC_IPDC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047213">
        <property type="entry name" value="TPP_PYR_PDC_IPDC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43452">
        <property type="entry name" value="PYRUVATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43452:SF11">
        <property type="entry name" value="PYRUVATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036565">
        <property type="entry name" value="Pyruvt_ip_decrb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="10" id="KW-0456">Lyase</keyword>
    <keyword evidence="8 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 12" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Thiamine pyrophosphate enzyme N-terminal TPP-binding" evidence="15">
        <location>
            <begin position="6"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme central" evidence="13">
        <location>
            <begin position="201"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme TPP-binding" evidence="14">
        <location>
            <begin position="396"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="446"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="473"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="475"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR036565-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CDM33866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="574" mass="63486" checksum="B0A16A3F7B2C956E" modified="2014-04-16" version="1">MTQDIKLAEYLFTRLRQLGVDSMFGVPGDYNLRLLDFVTPAGLHWVGNCNELNAAYAADGYGRIKGLSALITTYGVGELSAINGIAGAYAENTPVLHIVGTPPRPLQSARTFMHHTFSDGDYRRFANMSKHVTAAQVRLEDAATAPERIDYVLRQALVHSRPVYLELPDDMPDVLVSAKNLETKISIPQPPSSTQEPEVLARILEKVYSAKRPLIFVDGESTGLGIVEQIDALIKATNWPTWTTVYGKGLVNEQLPNVYGLYAGAFGDKSAQEYFDEADLILAFGLHNSDSNTYYFTTIPKPAVSIAFSGSTVQIDNDTYRDLSARNILSNILQSLDSTRLVKATGPPKQEITLANIKNTDPLAQDNFYRLVNPLLREGDIILTETGTASHGGRNFKLPPKCRIFGAVTWLSIGFMLPATLGTALAQREHNKVTESKSQTILFIGDGSLQMTAQEISVMIREKLNIIIFIINNEGYTIERVIHGRKQVYNDVPFWRHAQALNYFGADQEHAANNSFTARTCGELKDVLASEQIQNGSGVRLVEVFMHREDVQGVLLHLLNKQLAQEKGEAEQQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W6QCU3</accession>
    <name>W6QCU3_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RBR-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PROQFM164_S03g001247</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.31"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.3.2.31" evidence="2"/>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QCU3"/>
    <dbReference type="STRING" id="1365484.W6QCU3"/>
    <dbReference type="OMA" id="KCSHFYC"/>
    <dbReference type="OrthoDB" id="9977870at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20335">
        <property type="entry name" value="BRcat_RBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22584">
        <property type="entry name" value="Rcat_RBR_unk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031127">
        <property type="entry name" value="E3_UB_ligase_RBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11685">
        <property type="entry name" value="RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01485">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="9">
        <location>
            <begin position="55"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDM34523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="246" mass="28085" checksum="7DF81E152423A0CB" modified="2014-04-16" version="1">MGTAISMGLGLETEDHLAKYKKKRPSSNSFSVEIRQTGDSIENAISLTDTPKVEIWRECVSCRDDHLQDNMLKTKCSHFYCKGCLVRLFKNALRDESLFPPRCCRNPITASKTILGSALVQQHKDKVIELNDPDRTYCSDLKCARYLPRNGTRAKVCKCASCGVRTCRKCKKSAHDGPCLYKLDALLEELADCKQWQRCSKCSRLVELRTGCNHITCFCKFEFCYLCGKRWKTCPCIFADEDNLYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W6QCX0</accession>
    <name>W6QCX0_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S03</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S03g000635</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QCX0"/>
    <dbReference type="STRING" id="1365484.W6QCX0"/>
    <dbReference type="OMA" id="DGPSWMI"/>
    <dbReference type="OrthoDB" id="38045at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000220">
        <property type="entry name" value="UDP-galactopyranose mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43734:SF4">
        <property type="entry name" value="AMINE OXIDASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43734">
        <property type="entry name" value="PHYTOENE DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51971">
        <property type="entry name" value="Nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM33911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="530" mass="59414" checksum="4B68FE6339FD1083" modified="2014-04-16" version="1">MLNVARKTFKRVPSFQDLLQGRMTHPDISVDVLVIGAGPTGLGAAKRLNQLNGPSWMIIDSNETPGGLASTDVTPEGFLYDVGGHVIFSHYKYFDDCINEALPKEEDWYTHERISYVRCQEQWVPYPFQNNISMLPKEEQVKCIDGMIDAAIEARVTNTKPKDFDEWIVRMMGTGIADLFMRPYNYKVWAVPTTKMQCAWLGERVAAPNVKAVTTNVILNKTAGNWGPNATFRFPARDGTGGIWIAVANTIPKENTRYGPNNKVEKVNAYNKTVTLADGTTIGYEKLVSTMAVDYLAEAMNDSELIPLTKQLFYSSTHVIGVGIRGARPERIGDKCWLYFPEDDCPFYRATIFSNYSPYNQPDASKKLPTLQLADGSKPKSTEAQDGPYWSVMLEVSESSLKPVNHETLLAECIQGLVNTQMLQPGDEIVSTYHRRFDHGYPTPTLEREGALTQILPKLQEKGIWSRGRFGSWRYEVGNQDHSFMLGVEAVDNIVNGAVELTLNYPDFVNGRQNTERRLVDGAQALAKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W6QDI6</accession>
    <name>W6QDI6_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acyl-CoA N-acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S03g000860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QDI6"/>
    <dbReference type="STRING" id="1365484.W6QDI6"/>
    <dbReference type="OMA" id="CMLYCMV"/>
    <dbReference type="OrthoDB" id="512662at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052523">
        <property type="entry name" value="Trichothecene_AcTrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791:SF4">
        <property type="entry name" value="ACETYLTRANSFERASE, GNAT FAMILY FAMILY (AFU_ORTHOLOGUE AFUA_4G09540)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791">
        <property type="entry name" value="GNAT FAMILY ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="92"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM34136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="236" mass="27114" checksum="44B6AE31C96F7B2B" modified="2014-04-16" version="1">MAVEVLPLTETDIPGVIEIIQQAFADDPYFKWAFDSSKFNKQRNYDSLAARCHWGIKNALFYVAKETQETDSKSHSTTLTPAPILGVSCWLAPHPAAQPESWYSWFQSWALSFSQMLNNIRYFGRGGLRTNRYWIWKQRQAEAQASIWDDPRGYYFCNIVAVSPKAQGMGIGRLLFEAVTKRADEEGIKCYLESSKNVPNVAIYERMGFHMSKEMECRDGVDACMLYCMVRDPRTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>W6QEN9</accession>
    <name>W6QEN9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Zn(2)-C6 fungal-type DNA-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PROQFM164_S03g001225</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QEN9"/>
    <dbReference type="STRING" id="1365484.W6QEN9"/>
    <dbReference type="OMA" id="SMVTYRF"/>
    <dbReference type="OrthoDB" id="2579025at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051711">
        <property type="entry name" value="Stress_Response_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47540">
        <property type="entry name" value="THIAMINE REPRESSIBLE GENES REGULATORY PROTEIN THI5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47540:SF3">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="574"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="49"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="119"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="128"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDM34501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="756" mass="84607" checksum="2CA938C1DE2D8D44" modified="2014-04-16" version="1">METTSVALHESPRPAVKPNEITSTLPASKRKASDTLKDGVAQRQKITRACDWCKVKKTRCTGTLPCTRCTRLSMECKYNAAYSRGLPPDPLPVSPGPISTPTRNPAFEAVDGRISSFNLQGTGRDPALTNNLLSNQSQSQRQHVISPRHSPEPGSTDFEGNYLGPSSGVSFLNRVWSRLHQDETANFPDKLQIESSRNTAVFMFGDKPYSNPQDAEFTLPTLEKALELVGIYFDYSMVTYRFVHRGNVEEWTRQVYQNNIGLSNLPVGNMVARTAIVLMIIAVSTLYMEMRPGEMPGGPGERLESERWYAASKYMSSLESGPPRLETIQARLGQCLYLLSSSRANECWYSFGTTMQIVTALGLHRRGPAKVSNNGCSYLELELRKRIFWSVYTLDKYLSIMFGRPRLLHDEDIDQELPNETNDIDLLEEDPTRRTGSTDSMMIASVLHYRLGRILGDISRQLYSINTLSRDSPLETAIRLTSELEKWKETVPPLFNSVHPTSLIPPLCRQSQVLQLAYSHAMIHVTRSFLLNDFTDLSRRPKVPHPMVSSHVHKCIQAAEDIMTIVDGLAHQGVLIQSFWFTHYVCFCAVLVIYIHTIQQHRKSMGGSSSASVSSVGSPRDPDKLRQLFSLAESCQQHLAEATRKNCPSRRYGIILEELRQEVHRQISNGLSVETQAHSGANVTLYVSGEGSQNTDVKSVLFDTQGVDFMMQPPDLGTNPGDDAGFLESLEGSIWWAQLDSWALSNLPNDPSTFSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W6QEW7</accession>
    <name>W6QEW7_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Inorganic polyphosphate/ATP-NAD kinase, predicted</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PROQFM164_S01g001943</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAD kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QEW7"/>
    <dbReference type="STRING" id="1365484.W6QEW7"/>
    <dbReference type="OMA" id="IPKYQES"/>
    <dbReference type="OrthoDB" id="24581at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019674">
        <property type="term" value="P:NAD+ metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006741">
        <property type="term" value="P:NADP+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10330:FF:000033">
        <property type="entry name" value="NADH kinase, variant 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.30:FF:000009">
        <property type="entry name" value="Poly(P)/ATP NAD kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.30">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00361">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017437">
        <property type="entry name" value="ATP-NAD_kinase_PpnK-typ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002504">
        <property type="entry name" value="NADK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20275">
        <property type="entry name" value="NAD KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20275:SF26">
        <property type="entry name" value="NADH KINASE POS5, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01513">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20143">
        <property type="entry name" value="NAD_kinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM28132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="432" mass="46794" checksum="57F1112948E5A046" modified="2014-04-16" version="1">MLCAIIRRSSRRSSRLALRQHFSTSQPRHEVKDIGSLSQRLIPKYQESCDGELLCLQWPAPPRNIFLVRKDCAPAVTDSLIEFVNHVSSTYPSISVILESKTAAEVHSSLSFPVYSVSLDEKTTALHDKVDLTVTLGGDGTILHAASLFATCSNVPPVLSFSMGTLGFLGEWKFSEFKRAFREVYMSGAGAGARTPVLEGPEATVTQEIEMGPTGWSSVRGKSMGSTRGARILMRNRLKVGLFTADGTETTPIRTKTDQGQGVYVMNELLIHRGKEPHLAVVDVFVGGRFLTEAVADGIIISTPTGSTAYSLSSGGSIVHPLVPAILLTPICARSLSFRPLVLPSSAPITLRLSEKNRGRELEVSLDGVNLGQGMGVGMEVRVWNEEMRHGKNEWQGGVPSVMRRSVGGEAHEGWVGGLNGLLKFNHPFGEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W6QFB6</accession>
    <name>W6QFB6_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g002063</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QFB6"/>
    <dbReference type="STRING" id="1365484.W6QFB6"/>
    <dbReference type="OMA" id="MMPFRTE"/>
    <dbReference type="OrthoDB" id="3485856at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="312"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM28252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="371" mass="42137" checksum="3CC1F5309C2EBF7C" modified="2014-04-16" version="1">MSPESESDLMEKKTTPTGSFVNTPPTPPPSEEKKLSTSAQSVLNYFKLHRKGRRPQSWWQHRLTPDQYTEVLRVLDGDESLRGYVEDKIRLDYDPRRSRLTIRMPSPLHDLFCAEVVSKILNRLTELQKSDEAFGDFARKTKHLSTSRIRLPNDINDTEQTYSERCPDASFIHEYAKYPGVIIEVCYSQKVRAAADLADDYILDTNTSVNAVIALNIEYRGSKKATISIWRPHKITVDGVKELEAKAVIDMMPFRTESGLPVDDSKQPALQLSLRDFAPKSISQKYPNLDQDIHISSRELCDFLSSAEAEHEKQLLDQGVDEPLSPGTRKRRRAQTPPEQLSSEEESPKNAMKRGRLTRDSSGLFARGSES</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W6QFF7</accession>
    <name>W6QFF7_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DUF1212 domain membrane protein Prm10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PROQFM164_S01g002128</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ThrE exporter (TC 2.A.79) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QFF7"/>
    <dbReference type="OMA" id="FAHGCAS"/>
    <dbReference type="OrthoDB" id="413008at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010619">
        <property type="entry name" value="ThrE-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051361">
        <property type="entry name" value="ThrE/Ser_Exporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024528">
        <property type="entry name" value="ThrE_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31082">
        <property type="entry name" value="PHEROMONE-REGULATED MEMBRANE PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31082:SF4">
        <property type="entry name" value="PHEROMONE-REGULATED MEMBRANE PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06738">
        <property type="entry name" value="ThrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12821">
        <property type="entry name" value="ThrE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="528"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="554"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="610"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="646"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="689"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="738"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="764"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="835"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="domain" description="Threonine/serine exporter-like N-terminal" evidence="8">
        <location>
            <begin position="421"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="domain" description="Threonine/Serine exporter ThrE" evidence="9">
        <location>
            <begin position="695"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="130"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="269"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="319"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="360"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="11"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="139"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="286"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="361"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF06738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDM28317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="870" mass="95005" checksum="A1755652A2A00E88" modified="2014-04-16" version="1">MAGGYFDLPISRSASEEGSSSLSRSRSFTSSLLIDSFQGQPVSQVRSFSDASAQDKYRNAGILKNTNRVKLTDSESDLREQPTGPMVEFRLDQRGTELPQRPLPTANIPGFQEKVSSSSPLAPQVEDDHFSASAGVTGLTISTRTSSPGTSAEYELGQGTNDKGRAICFAHERAHRLTSLLNCPHNCPKQSPQCSLVSEIGSTPTEVVCQTADEDKFPVISFPEKQQLFDNLIDEHEAEFLDGRSTPCNSGAHYLVHQMSPRDLNFLTRLRPQSPGLHSSDQDTVSEDRNSYESAERTTSYHGGILSSLLKLYEKPRYNHNQGRGRYGRSRQGSSSEFSGRGLSPDSVWKPQRKWYDKSTARSSISMAGSSRRSGSPFAMLTRSRSSGAAVPNLSRSRPKAQLEDEIHITVHIAELLSRQRYLIQLCRALMKYGAPTHRLEEYMRMTARVIQIDGQFLYIPGCMIISFDDASTHTTEVKVVRSSQGIDLGKLADVHEIYKEVIHDVIGVEEAIQRLDEVMKKQSKFHIMFLIFAHGCASASVGPFAFNARPVDIPVAFLLGCLLGVLQLILSTKSSLYSNVFEISAAVLTSFLARAFGSIRFNGEPLFCFSALAQSAIALILPGYTVLCASLELQSRSIVAGSVRMVYAIIYSLFLGFGITIGTAVYGLLDSQASTAYTCPASPIHNEYLQRFPFVILFTVCLAIVNRAKWKQMPIMIVISLAGYVTNYFSAKRFYSNTQVSNALGAFVIGVMGNFYSRLQHGLAAAAMLPAIFVLVPSGLAASGSLISGITSAEEMTRSPYAVVNNGTQGFVDAAKKLSADEARSQSYGVVFDIGYGMVQVAIGTTVGLFLAALVVYPLGKKRSGLFSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W6QG20</accession>
    <name>W6QG20_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyl methanesulphonate-sensitivity protein 22</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S04g000231</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1365484.W6QG20"/>
    <dbReference type="OMA" id="DNRIDYM"/>
    <dbReference type="OrthoDB" id="2386201at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035361">
        <property type="term" value="C:Cul8-RING ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019021">
        <property type="entry name" value="Mms22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28122">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SUBSTRATE RECEPTOR MMS22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28122:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SUBSTRATE RECEPTOR MMS22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09462">
        <property type="entry name" value="Mus7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="335"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="717"/>
        </location>
    </feature>
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    </feature>
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    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
            <begin position="1007"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="172"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="231"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="388"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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        </location>
    </feature>
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        </location>
    </feature>
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        <location>
            <begin position="525"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="556"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="606"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="670"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="850"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="990"/>
            <end position="999"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM35350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="2296" mass="257361" checksum="60473DC73B937EE0" modified="2014-04-16" version="1">MQMESWRQRGYVPDSDEEDGFDSLDAKNGNAENSPVVENIEYIDNPSSSPKEGATSVTKKQREYVRAENGSITLSDTEEVVRRHTNRTSPHLTNVAHDETTPNPRRGRKTYGLRSSATKSTKHRNSELHITNAFVNNTTSIYDFPTSSQEHDRPQSKPSSRESTPKALKPVRSSQSQDATSSTRSSSPDELALTPQPTRKKNTAAECVQPIEAPPLPPPLPPQEASEDDSPLSSLPSSFGSPSANDSTEIHADGMMEAEAETLIDKEADLPQTVLVELDANPDDVLPHLDIPEEVFRGLPHAAQRTFRKRNAIQMHPYHLEQLKFAQQLQARGVKPFGRPPQERKQVTDESQGQDSYDPDAPPSSPPLEEYLPPVRHERHRGPQSATQRREHHDSEHTQPSQARLAKRQKTSHSGTPKERHNLHKPSKPRGVRDRNTPTKNQNAVSIYDLSSSPPHTSRLSSTSRTPRASEGGFRFPRGWSPPGEIAKSRAQEIQEAGQVQSAGAGTDNEGEVQSISSNSQSDQEETKSDAEEREIRRFQRMIRGALPASHARLNQKNDKEKSLKLDRHASSQRPDGKGVARKLIRRGDRSKQPATQQARGLFDLGDSDSDDEDNRNDALGNASVANESSQMLTGTLSLEDPFALEGGDISEDNRIDYMSAPVLRNPTGSRHKRNSLKRPKSKQSLPNGERQPKRPRQTRMTDASYRARRTKKPSAVQRPRIGILDAPDVATKPLKEQSRLLRVATRRPRSRKDGGRQSPTQKFLKLASREDTVDANESLREWKRGAIQQARISPPRSRAPENRHWTTNLSILSARAKSNAKNGRIQFLDAEADTGFSSTNTVEPERVQAPPESSAVSVPPNQPPVAVSSARRKPEQHGHTWIIPRNVAITSLKRNTVRPAATSLAGPGRNQKMVPAMFNQSLSLLNRHYKNQRTSKPYKPSLTLDRYVSDSRSLSTGGNSSPMNASVAAAAATVSAEAKTQTPTPKASVSRRRLKKHPPKRINLDADEFRQNPDPATIVSDDLEPPIMTHTGDVRPPSFGVAGLFNWQRFYPVDFGVPSLRDNTFFHGSTFIGSGEFSRSLQITGRDFDGDAASFSIQLRDETFQWSRWNDTVSSEIGQVFDVIIDNVERSAVTSPETGITAALGVASRLYRLLIKYITENLVFTDPVDRTEFVTRAMGLVSQVRDPLAAFLTSDEYNKSGLVKIACFNMVFSNQIYQVASHRLVSPAIATEVLDIVKISAKDVAGLIASKVGSSEFKTLLKQINQPEHRESGIRDEYPSAEAYVITKHLLRSSENYKGCFEDNQLETFNNKIIRNERDVGSLEAGWHGMFTVLPLNEIDPLGIARPGYQLTAANDNWILAKRLLAPALDHFESDSKAQPISYNIYCRTLFLRCHRLINSWGWRECKPILDTLFDFFAKNTLHNLKLEEARGSPSFLDELDNNPSLDARVGEPCFHTFLKIVASGLRFLAKRYDKKKIRNFAWRLLPNHGRVYPKEQPLQHEDLEALRNHHDLLSTLYWAVPDGCRPRLETIRNLVHPATSHREACSINLRSWSRLVRFKLSTDEEVSGLDPFGDWYGYFVTELQQQHSYARKEIEAQNTGDNRVSQQVVERTISQNQRQVETLLSNALTGLRIAVQLAPKMEHARRLVLRTPFESLLALFNPKLPRVNVVVSEALQVLVAYTQKDFLVTSTSSAPAAMNTDEDSQEFGDWDAIQAVWDQQSSPGEGIEHVEKAFHPIVSRLVSNCFGEDHCPEDIILLNVVECWTSIAQVLIRHGLRNWDNYLSEFGDDSWTRLRQTVQTRKFAPLFLATCIEKDAHIVSDCRIQVMSMWMSSLVERSSMLKFQHRLTEALLNGSPTDPLLANLPFSKDRKIGRYTITLEEIGSRRLSLLSSLSSNMREQLYGMELSGNRNFSVTKQEYSEMLQRVMTSMKSNYQELGNGTAQTAQGEYVEFVQRVIGFLQQHTSDIKPIDPFFTDPASFPLPSTDPRYIVAKLKRYESKLSSSKEIQTLTGFVQSISERAAIDGQQSYLVEQLHTSMKHTYEAGDYDKPTLRAVLLQCVFPAYLEATLPNRAAWILSRPIIQTITLEFKTLLCNIDTLDPACVSSVIDIIDVVCRASCQALGVVAFRRHRLQSPTTLVMLAAFLDMISSALPVVDYIDRVTGAGEGILTHIEWIRDFAKAVGRCLQSTDPDIDLSSSSARVIFPSTPPSCDSRKTEFFSTANNLASNDLQLYLRKWSCHQDKYYFTRPGHELQEIKVEPEIAVLVASQSEAQKVFEDAARGFVDRATVLELLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W6QGJ0</accession>
    <name>W6QGJ0_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S03</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S03g000008</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QGJ0"/>
    <dbReference type="OrthoDB" id="4239138at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM33284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="280" mass="31712" checksum="75EA575B6366E7C0" modified="2014-04-16" version="1">MANNNGHWPPNQHFPPFTIALEPSPRSDPPSASIIKPPFETESMTERFPVQYLPVQYPQASCNKSQPASLQAEGNFVLYSQDEAISFQEYEYAQVNRTIGFYGQRAAFGRMQTVFQGSPLFSTHCKKVFPNEPDFSLIDQFVAQNNTVLEKTLSNLKRCDPARLEDFYRSAFRGLNLVACEAILAAWMGVLDLSILGGIQNTYLQKPPCSGFCIQAPSPLTIDDPGDFLYYILRGNHGEKLPFKRLLGALHFASIEATDRRNVETRLLLREIEIWRELNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W6QGK0</accession>
    <name>W6QGK0_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S04</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S04g000441</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QGK0"/>
    <dbReference type="STRING" id="1365484.W6QGK0"/>
    <dbReference type="OMA" id="GEEPIFK"/>
    <dbReference type="OrthoDB" id="5329385at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031342">
        <property type="entry name" value="Mug163-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17119">
        <property type="entry name" value="MMU163"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM35560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="332" mass="36669" checksum="A63D96F2DC2EAF86" modified="2014-04-16" version="1">MPKLVSLRTSLLNQPKSPVSGRLFASVSRQRLAQLRHGLLSEPWLTSTSVAPLPVTYFSPAWVRREHVEGLGRNDHQPPDERTLKLGKTLRILSPLLPTILYNTLPTEILAPSVNLHLFPSTHPHLPTVKGRTLYRAALWTVPVAWSSVPLVGNVKLQILSERIVRAGTLLDPTRHGVHHDCGDERLLVRWKTEPRTESRPFHGPASWNINSTNPSKNAPFSQNSHLSNSTKGTNNGLSVLLGGEEPIFKLSKEEQFTGIFIFSFDEEGRILTHTIEHADEADGWDRTAKFVTLTDWLIGKARGSLDPAANTGLAMATGESHGLASNSGRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>W6QH57</accession>
    <name>W6QH57_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S01g002768</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QH57"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM28957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="53" mass="6005" checksum="EE68C3E7DC78C30B" modified="2014-04-16" version="1">MHGQTTVDAIFGKESDIFSLRSKLPVCSEFEQYFDSGEIVIVPDVNTRITNRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W6QHC9</accession>
    <name>W6QHC9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Tyrosine-protein kinase, catalytic domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PROQFM164_S04g000257</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QHC9"/>
    <dbReference type="STRING" id="1365484.W6QHC9"/>
    <dbReference type="OMA" id="GNWYNKA"/>
    <dbReference type="OrthoDB" id="2158884at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07830">
        <property type="entry name" value="STKc_MAK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000233">
        <property type="entry name" value="Meiosis induction protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000314">
        <property type="entry name" value="Serine threonine-protein kinase mak"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="23"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="355"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="406"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="470"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="513"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="602"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="671"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="377"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="477"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="517"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="532"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="602"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM35376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="763" mass="84431" checksum="1623A81EC0FD52E1" modified="2014-04-16" version="1">MTVTYDMPTRGSHTSMASLEDRFEVIKEIGDGSFGSVAVARVRTAGAHIARRGTMVAIKTMKKTFDSLGPCLDLREVIFLRTLPIHPHLVPALDIFLDPHSHKLHICMEYMDGNLYQLMKARDHKYFEGKHVKSILYQILSGLDHIHAHHFFHRDIKPENILVSTSGPNDSAFSRYSNLVTPPSTPPVYTVKIADFGLARETHSKQPYTTYVSTRWYRAPEVLLRAGEYSAPVDMWAMGAMAVEIATLKPLFPGGNEVDQVWRVCEIMGSPGNWYSKSGAKIGGGEWREGSRLAHKLGFTFPKMAPHAMESVLQPPMWPAAFSEFVTWCLMWDPKNRPTSTQALNHEYFADAVDPVRPKSSTSSRLLGRKQSEKSFRSPNLTPGDSPTLSSKPSWFRRSLVVRSDSPVPSAEESPARPSAVTQVTVPEIQPVKARPPNIKRATWANGAPMPILPSIRPVSPLSNSVTAQANATLAHSQSSKSSSTSASSKIGRQLSLNSHGNHYDQNRLEAERRLNGSGTSTPTTKESFFSHLRKRARRLSGRNQSAPNDDVEANAGCIPWSNRSSVALDGPTSDPKQGSDLNELDKALQCVKYSLDSSTLSNVPVHLNNSADGQTKRQSMPHVTSNNPAPISSRTRRAMQMSTHPVHRYETPEEEDELLDEVLHSASKAARRLAQTQSMAADSHSAARRQPDNSRAQQNPYPTPSPTAKETAAFGQQSTPSKLNIHKIDPMAASRHWPTPPYEEAEYHNNKSDYFAPGSNYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W6QHD7</accession>
    <name>W6QHD7_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Genomic scaffold, ProqFM164S04</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S04g000267</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QHD7"/>
    <dbReference type="STRING" id="1365484.W6QHD7"/>
    <dbReference type="OMA" id="ISCIYWD"/>
    <dbReference type="OrthoDB" id="1751210at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055509">
        <property type="entry name" value="DUF7082"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39463">
        <property type="entry name" value="MEDUSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39463:SF1">
        <property type="entry name" value="MEDUSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23305">
        <property type="entry name" value="DUF7082"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7082" evidence="2">
        <location>
            <begin position="351"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="524"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="524"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM35386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="657" mass="71095" checksum="FDD665CAF434AE02" modified="2014-04-16" version="1">MSAFQKPVAGAITDYGSTRSLHDAASYSNYGQSPYVTTAMVPSPMADQASQISDCVPYLPNEYASSYEESQSPMMGARHRQLPEIVTYSPQRGSEGTRVMVQIQCPYDLHASSYAALYVVFGSKKCESLLHFLGFQDSAFQYGLSADVPAFLSTGSPSFAVPLSVLMETQDDCPATSLQVGVYTYEQASHPSPSGDSRKRKFSYSDAPVASAKRHNGSVIPKVEHHEGYHGRSVSASYSPYLQPLPAMVGFVAPYHSASSPQTGSGHYSSVSAASQPALRVPSPITPAWSPSFVSVSNDARNGLALTHVPQHKGPPQRGPSNPTLIRTSTMQTHSMPHNPAFNPYAIYPTKAILKLNGDLDTMTQGWTKEERACRRRLVQFTRSQTGSTIQGEFKAVSPDDRAPNSICISCISWEDKNECYVTSVDTIYLLESLVAVRFTVEEKNRIRRNLEGFRPLTVSKAKVESEDFFKVIMGFPAPKPRNIEKDVKVFPWKVLSQALKKIIGKYSASYSSTASAIPTPMTTTYTSHASHGTGSDSGTEPHTANSPQSISDSGAGHSYHGMPVQTYSQADHSSHLSSAPNIRSMSAVSQPYTSAGAYSYPAMSHQNGLPPAAPRASWDMHPLGHNTPHTGAPGNGGCYTYLDPVYSVHDTAHGGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W6QHJ2</accession>
    <name>W6QHJ2_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WD40/YVTN repeat-like-containing domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PROQFM164_S04g000781</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QHJ2"/>
    <dbReference type="STRING" id="1365484.W6QHJ2"/>
    <dbReference type="OMA" id="SIWDYSK"/>
    <dbReference type="OrthoDB" id="10261640at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000643">
        <property type="entry name" value="60S ribosome biogenesis protein Sqt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051179">
        <property type="entry name" value="WD_repeat_multifunction"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19857:SF8">
        <property type="entry name" value="ANGIO-ASSOCIATED MIGRATORY CELL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19857">
        <property type="entry name" value="MITOCHONDRIAL DIVISION PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="124"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="228"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="11"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDM35900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="515" mass="54707" checksum="3B8E538AC62A3346" modified="2014-04-16" version="1">MSSNDPHHENEEDYMQADDAEEIFERDEDHPMSEGEGEYDDENMTIEDEITFQNDSVAHFDSHSDSVFCVAQHPVHNNIVMTGSGDDTGYIFDSTPAPRPVLPSSYESNPQPKERESLAPLAKLDGHTDTVNAVTFTEPTGEYAITAGLDGKLRAYRDTTPQKTGLAWEFFGEVQEVEEINWMAVCPYQQGNEGTQNVIAIGANDGSVWVFRIDHTDPGQPISIIQTFFSHTESCTAGAWTPDGNLLATVSEDASFYVYDVFGAAAAAGIEYSQGTNAILGLTAEDQRFAVEGGLYTIAISPSGGIAAVGGAEGNIRVVGLPRVTASVPAAKGKGKGTPSQAAGSTAAGTIMAALQTQTDNIESLSFSQAPFTLLAAGSVDGSIVMYDAAHRFAARRHIRDAHEGSAVVKVEFLPSSKQLGATVSGPLANAPAAHQNRSWMLTSVGLDGVVRRWDARGGTAAASQGLMQEWKGHMGATENDEGEQAGGIMGFVQGFDGKRIVTAGDDGISLVFEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>W6QHR2</accession>
    <name>W6QHR2_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">asparagine--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Asparaginyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">DED81</name>
        <name evidence="14" type="ORF">PROQFM164_S05g000161</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>tRNA(Asn) + L-asparagine + ATP = L-asparaginyl-tRNA(Asn) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11180"/>
            <dbReference type="Rhea" id="RHEA-COMP:9659"/>
            <dbReference type="Rhea" id="RHEA-COMP:9674"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58048"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78515"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.22"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.22" evidence="3"/>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QHR2"/>
    <dbReference type="STRING" id="1365484.W6QHR2"/>
    <dbReference type="OMA" id="DCCLYPR"/>
    <dbReference type="OrthoDB" id="1931232at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004816">
        <property type="term" value="F:asparagine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006421">
        <property type="term" value="P:asparaginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04323">
        <property type="entry name" value="AsnRS_cyto_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00776">
        <property type="entry name" value="AsxRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000040">
        <property type="entry name" value="Asparagine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1910.20">
        <property type="entry name" value="asparaginyl-tRNA synthetase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004522">
        <property type="entry name" value="Asn-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048952">
        <property type="entry name" value="AsnRS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00457">
        <property type="entry name" value="asnS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594:SF16">
        <property type="entry name" value="ASPARAGINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594">
        <property type="entry name" value="ASPARTYL/LYSYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20917">
        <property type="entry name" value="AsnRS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="13">
        <location>
            <begin position="274"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDM36328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="577" mass="65487" checksum="18B35B9B4DCEC83C" modified="2014-04-16" version="1">MASTSIYIDEDVGKDESSATGTETAPYKTLVHAYVEHPPTTEGIQYLTRKSLTDAAGEDVDPAAKLEWKPATKSAMKKANNLWEQRKKKAAKEHELAIREKAEADKRQKVLEDAKKVVIKEDTSLPKPVRIRLDVTDPAIVKLRTAESDEPGTRVRVLGRVHRARAQKDVVFITLTDGYGYLQCVLTGDLVKTYDIMTLTLETSMSIHGEMRAVPPKQHAPNDRELHADFFEIIGKAAGDKEAITTRVAPDADPQTLYDNRHLVLRGETSSSVMKVRAATLRAFRKAFEENRMLEVTPPAMVQTQVEGGSTLFGFDYYGENAYLTQSSQLYLETCLPSLGDVYCVCPSFRAEKSLTRRHLSEYTHIEAELDFITFTDLLDHLEDVICRVIDYTLAEPEIAGYIKQLNPDFKVPSRPFRRMKYDDAIQWLIEHEIPNEEGQPHKFGDDIAEAAERRMTDIINQPIFLTHFPADIKAFYMKKDPEDRRVTESVDVLMPGVGEIVGGSMRMDNWDELMAAYKHEGMDPSPYYWYTDQRKYGTSPHGGYGLGLERFLAWLCARYTVRDCSLYPRYTGRCTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W6QHW5</accession>
    <name>W6QHW5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Armadillo-type fold</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PROQFM164_S03g000483</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the importin beta family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QHW5"/>
    <dbReference type="STRING" id="1365484.W6QHW5"/>
    <dbReference type="OMA" id="SFHYVFH"/>
    <dbReference type="OrthoDB" id="361693at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000362">
        <property type="entry name" value="Importin 11, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058669">
        <property type="entry name" value="TPR_IPO7/11-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997:SF7">
        <property type="entry name" value="IMPORTIN-11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997">
        <property type="entry name" value="IMPORTIN-7, 8, 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25758">
        <property type="entry name" value="TPR_IPO11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="5">
        <location>
            <begin position="37"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDM33759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="1052" mass="118114" checksum="209A7C033A8C0508" modified="2014-04-16" version="1">MAFAVEVQGETNPLTPQNVLNALVHAASSSQQQVQTGTEQLQYWEKQGMYYSFLQNAFLDYSLPNEIRYLAIIQLKNGIDKYWRKTAPNAIKPEEKERIKSRALEAGIVEPAPLLALHNSLMIAKIMRFEFPHDWPDAILFIISSLRSSVEPGANPLQLPRTLLMLLQIIKELSTARIQRTRHNLQSVSPEIFQLLGGIYVDKVNQWGTILDQGGASEGELLETLELSLVSLKVLRRLIIAGFEHPSRSQEVQGFWELTHSHFSKFHSLVDGSTNLPEPIHRAIEKHLLQMSKLHVEMAKTHPASFALLPDSISLVKSYWSLVVKLGEKYDSLGAGGENEGKSLPEKTGLRALLLIRACAKMAFNPANTFKYQTPEDKEERKQSVQLVKTQLFTEEFVINVMELLVTQFFRFRKIDFQEWEEEPEDWEKREEENADAWEFSIRSCSEKLFLDLVIHFKDLLIPRLLTVFYTFASTDNHNVLLKDSLYSAVGLAAASLEHHLDFNAFLEHTMVVEVQSQEPEYKLLRRRIALVLGQWVPVKAGDLNMNAIYQIFQHLLGKHDPLNDLVVRITAGRQLRSVLDSYEFSPEAFMSFAPTILESLMSLVQEVESSDTKMGLLETVRMVVVKMEDHITPFSDRIISLLPPLWESSGDEHLMKQAILTLLSSLIQSLGQESVRYHSLILPLIQSSVEPGSETIVYLLDEALDLWHAIIQATPSPASPEIISLLPSLFPILEAATDSTPQAIHILESYVFLAPQEILSDRFRFQLLVILESLLKSTTKQRLGVIPRLVDLLLRGAETVDGGSEATYRVISQSLLESSFLASLLEGLYSAHEASQTSGPNRKSSPVVGVVESDYYSVLARLALASPTILASSVAAATNSSEEQSLTWIMTEWFLHYDNIGSINQKKLHVLALTQLLALQGAPLDPSLPPPPPAYILSFLQSYLSVWTDLITELADGSTDPNADYLVCWNAPAGSATAMPETTQEVESPEIIRRRDWQSGDAIHRFMIRDFVRHRLQEVIAGCGGAQRFQDEWLVNVDTDVVAAFGALGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W6QI26</accession>
    <name>W6QI26_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cation efflux protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PROQFM164_S04g000547</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QI26"/>
    <dbReference type="STRING" id="1365484.W6QI26"/>
    <dbReference type="OMA" id="DVMIHIN"/>
    <dbReference type="OrthoDB" id="435980at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098771">
        <property type="term" value="P:inorganic ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030003">
        <property type="term" value="P:intracellular monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1510.10:FF:000013">
        <property type="entry name" value="Cation efflux family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1350:FF:000010">
        <property type="entry name" value="Cation efflux family protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1350">
        <property type="entry name" value="Cation efflux protein, cytoplasmic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050291">
        <property type="entry name" value="CDF_Transporter"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43840">
        <property type="entry name" value="MITOCHONDRIAL METAL TRANSPORTER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43840:SF15">
        <property type="entry name" value="MITOCHONDRIAL METAL TRANSPORTER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="9">
        <location>
            <begin position="37"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDM35666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="371" mass="39971" checksum="E3F7BA7D00544233" modified="2014-04-16" version="1">MTQTRDHGHSHGPGHHHDNTYLTSTNKRDAGVRITRIGLVANLCMAIGKFVGGYVFHSQSLIADAYHALTDLVSDFLTLGTVAWSLKPPSERFPNGYGKIESIGALGVSGLLLCGGVFMGLNAGQVLLAHFYPEVAETVAHSGILGHGHSHSHGPIGPSIHAAWIAGGSIVVKEWLYRATMKVAKERKSSVLASNAVHHRVDSLTSIVALVTIGGSYVFQDATWLDPVGGVLISLMVIKAGWGNTCTSLLELADTTVDEEVRHSVEDAASLALKDIQDGHEVIVRDVQGLKSGQNYLMDIELAVPGAWPISRSQHIEEVVRHAVGSGVRGVKRIKVRFIPAEHQDLTFSDEFVAQDVSGDPETLQDTRKRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W6QI66</accession>
    <name>W6QI66_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glutathione S-transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PROQFM164_S03g000603</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the GST superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QI66"/>
    <dbReference type="STRING" id="1365484.W6QI66"/>
    <dbReference type="OMA" id="SFYQAIF"/>
    <dbReference type="OrthoDB" id="422574at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03048">
        <property type="entry name" value="GST_N_Ure2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051:SF8">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE GSTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01151">
        <property type="entry name" value="Main.2:_Nu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="3">
        <location>
            <begin position="2"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="4">
        <location>
            <begin position="92"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDM33879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="238" mass="26951" checksum="43AF5CC8B2BBACAE" modified="2014-04-16" version="1">MSSNITLYTWPTPNGIKASITLEELGLAYKTEGLDISSNSNPQKEEWFLKINPNGRIPALLDGSQRVFESGAIMTYLVDKYDTDRKISYAPGTSEHVEQTSWLMFQMGGLGPMQGQANHFRLFANTRSDYAINRYINETKRLFSVLESRLKESPYLAGEKYTIADIASFSWVRGAPVSLEIDLSEFPALKKWVEEIDKRAAVQKGVDVPHSTRTPEQRAEFFRNCRAKIDAMTTSDQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W6QI87</accession>
    <name>W6QI87_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tetratricopeptide-like helical</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S03g000623</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QI87"/>
    <dbReference type="STRING" id="1365484.W6QI87"/>
    <dbReference type="OMA" id="IEAYQHC"/>
    <dbReference type="OrthoDB" id="434695at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034044">
        <property type="term" value="C:exomer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000146">
        <property type="entry name" value="Clathrin-coated vesiclec protein (Bud7)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000149">
        <property type="entry name" value="Clathrin-coated vesiclec protein (Bud7)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015374">
        <property type="entry name" value="ChAPs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31975">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN 7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31975:SF1">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN 7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09295">
        <property type="entry name" value="ChAPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="429"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="469"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM33899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="675" mass="76142" checksum="1F501B471AD5F4D0" modified="2014-04-16" version="1">MVAPAVPEIHEEEDIYVAVDARTESLQSLRELGPPDLVYLVKQPKANSTRQTGLYHHVTGIDASSSASLAAYVNTLTFSPLDKTHKVVSGIYCCYNAFSHLDMRVEVKIPGSLESYCIDERGDKRVATEALWLETFLCAVLRAYLYADDGSGDSVKKIVGVRRFNPVTNTEMEHKFLDAAEKLFFLGRQLSSDPETQVPNTVSNHLTSGILKYIHTTGRYTSGINLFEKLRTKDVEVSSLLARVQIMADEEVQAVRLMYDALQDVPMDYALLDCQASFCQSKGESEMALECAKRAVTAAPSEFSTWARLAEVYVGMERWDLALLTLNSCPMFTYQDKDTPRMPQPSRIMLPILAESLLDEIDEGQPKQGDPHDYVHPSLRKIHAASYQGTFLKAYNLLTKIAAAIGWDQLLKARSQVFVMEEEYRVERQHVPKPATNGNSPANEDDSSSVAGPDSSEPSSEETTNGDAGDSHPESPLERPEQTVASEVAKSGKEDPDPSHASYTQFRNKRLCERWLDNLFMVLYEDLRIYTIWRTEMAQSRQQAMEYKKSPTEWEILGELAQRLHHFDESIEAYQSCLATRFSPKAMRGVLRLYEKRNDTRGMLGALIRLIAWQYRWYSEFSPELLFLVRKLIEDEGAVKVRSIVQATNLPQAVLDLTHQYCQLCATFRSSGSDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W6QI95</accession>
    <name>W6QI95_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PROQFM164_S04g000617</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QI95"/>
    <dbReference type="STRING" id="1365484.W6QI95"/>
    <dbReference type="OMA" id="YEETKFC"/>
    <dbReference type="OrthoDB" id="5215911at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF50">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G00430)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="124"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="152"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="212"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="345"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="399"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="432"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="461"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="498"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="527"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="240"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM35736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="582" mass="64764" checksum="1296196D16D264BA" modified="2014-04-16" version="1">MSSTLPNSGTGNNSMWPPGTLHLADATASDGKTIILQPRPSDDPNDPLNWAPWRKCLNMGLVCFYVAMVAEFINANTPTWGPMETELGFTSEILNDSYAAGCAALGVGSVILIPFALKFGRRPLYLFSTIVQFGVCIWSAKMQTVGDLMAINVIQCFFGSLAEVIVQMTIADLFFVHQRGRMNALYVWTWLLSSYLGILIAGFVASGLGWRWIWWLNTIIFGVTMFVVGFGYEETKYCPPASPATPDVQLDTTNEDRSIAPNPQEEDRNKDDLEKLSSARMKEIYAEQGFADLSSIKADEPNITAVTINPNIPMKTYWQRLALTTTTSSSNTKNESFFRHMYQPLIVLTTIPAIAWTALVYGILVALGDVMSTTMSAYLPKAPYNFSSYEVGLMSLPRMIGVSIGALIVGPLSDWWILFLSRRRNGIFDPEMRLWCMIPFLPFIIAGALLFAIGLNDNRPWPVIAVGLALYNIGVTPINTLTITYLTDSYKDIVGDALVGVTLTRNSFSTAFIFALSPWVAKVGLKNTFITILVIAIAILMVFVVFLRYGKAFRRIVAPQYVRYAARQYKERDWLHIIACET</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W6QJT7</accession>
    <name>W6QJT7_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cell-cycle control medial ring component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S01g003640</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QJT7"/>
    <dbReference type="OMA" id="YILPRMP"/>
    <dbReference type="OrthoDB" id="5366541at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.286.70:FF:000001">
        <property type="entry name" value="Uncharacterized protein B2O8.280"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.286.70">
        <property type="entry name" value="Get5 dimerization domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049256">
        <property type="entry name" value="Get5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024737">
        <property type="entry name" value="Get5_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17183">
        <property type="entry name" value="Get5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12754">
        <property type="entry name" value="Get5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Get5 N-terminal" evidence="2">
        <location>
            <begin position="6"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="Get5 C-terminal" evidence="3">
        <location>
            <begin position="179"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM29827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="230" mass="25251" checksum="4614FC97AE536FAC" modified="2014-04-16" version="1">MSELTFTKSFLSTLDSRPIRLRADYVFDPEQIGLRVPYTLPRLSAAHPPMPKKVRSVQAPGSSKSITVRVKSARNPALEFLISNAPLSTTSVQDIRDAVQVRVTDAQGGQVPLDKIKILYKRKPVTGTGKTLAEVLADEPAIMAGGKEVEIGVMIIGGAQVVESAMAQPEITEKRDESPPKAAIGPSGEEVLHTEAFWDDLQGYLEQRLKDEEEAKRLRLVFKEAWSSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W6QKB8</accession>
    <name>W6QKB8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative RNA polymerase II transcription factor B subunit 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PROQFM164_S05g000698</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TFB1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QKB8"/>
    <dbReference type="STRING" id="1365484.W6QKB8"/>
    <dbReference type="OMA" id="NRPNFDM"/>
    <dbReference type="OrthoDB" id="360521at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000439">
        <property type="term" value="C:transcription factor TFIIH core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13229">
        <property type="entry name" value="PH_TFIIH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000406">
        <property type="entry name" value="Putative RNA polymerase II transcription factor related protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005607">
        <property type="entry name" value="BSD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027079">
        <property type="entry name" value="Tfb1/GTF2H1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013876">
        <property type="entry name" value="TFIIH_BTF_p62_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12856">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03909">
        <property type="entry name" value="BSD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08567">
        <property type="entry name" value="PH_TFIIH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00751">
        <property type="entry name" value="BSD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50858">
        <property type="entry name" value="BSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BSD" evidence="8">
        <location>
            <begin position="225"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="438"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="452"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM36865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="642" mass="70982" checksum="9CCE70A829B164C5" modified="2014-04-16" version="1">MSPPSGAASYKKKDGTLAISADEKSVSWSPAVAGAGNTITIPVVNITNLQQTPASNPKVMLKIFSQASDAPPNSTPDQYVFLFTAGANARPQADVIKDTLSARVNAVKSGTPSQTPGARGASEGLSAAMAIANAVTSAGTSKNPVDEENRLRSDIELQQSLLRSDSNLQRMFFEGLHTKPEALSSGSFVSQFWSTRLHLLRAHAIEQGQIRGSYNVLSSLKPRVEDNVTRLNISKEQIQLIFTQHALVKRVYDENVPKLSEQQFWSRFFQSRLFKKLRGERITEADATDAVLDKYLRTDEAAQPDRDTNIHHFLDLAGNEVNHSERSGNRPDLDMRPSGLDKVPIIRTLNSLSEKIMANVAPIDGDMSAPIGINEEAWKRLQLQDLCSEEHQSPITLNIRDQSRFFTHGQEEDKTKQFVKQDPEQLLQILRTEINQNLPSQGNTQLGKLVDPGDDEDEEMEDAPASRRPVGSSAALHDAFSQILEALRERRAQMKERATSETYGLSIALFDRLTLTHATTTEFLHQFWQAFLSGNPDRAGEVASLAESLHRAMERIKAVANDAEAERKVEVDRLKKQARDMYESTGRKLRVNLEGVEGGQKVVNQLLGPTLHALEVASTRYQKELAEQNKEAAMAAQDTAGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W6QKF1</accession>
    <name>W6QKF1_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Monooxygenase, FAD-binding</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PROQFM164_S05g000309</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QKF1"/>
    <dbReference type="STRING" id="1365484.W6QKF1"/>
    <dbReference type="OrthoDB" id="655030at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051704">
        <property type="entry name" value="FAD_aromatic-hydroxylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46865:SF7">
        <property type="entry name" value="MONOOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G07040)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46865">
        <property type="entry name" value="OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="4">
        <location>
            <begin position="46"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDM36476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="372" mass="40863" checksum="7193E41D2E4363AC" modified="2014-04-16" version="1">MKCMGKRQAFFPANNFIKPSLGFSTKYEIMRGDLCRIVYGLSKSRAKYIFGTSIESYEENDKEKTINVRFANATEDTFDLVIGADGQGPRTRKMMLGREAPDAFRPLNGRCIGYFTFPQPIKEGEGYVATMYSAPGGRGIMLRRRNAQEIQAYLGGQTNSEKLKEHLRGDVAEQKEALKVILQGAGWRADEILGYLKDSKNFYCERLGLVKMPHWSRGRVTLVGDAAYCPSVMTGMGTTSGIVGAYVLAGEIGRHCGGPSEEGNDSLMAAVQAYEQTFRPVINQVQAGVAEDEGLWHCTWKLSYGSCFPFEIGCSQQVLYGSCQKLETSDIQRVAPRLDNTNCATVQLCSLGTISLISTSSKLIISGSKSAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W6QKP5</accession>
    <name>W6QKP5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S05g000848</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM37015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QKP5"/>
    <dbReference type="OrthoDB" id="10551574at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM37015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="87" mass="9884" checksum="37E43B4BCF3D842C" modified="2014-04-16" version="1">MHLILDSPVKETNLFSFGIRVLTLLKAVDGSWRNQAGPWPLVLLLAEDKSRDNANIKYYTAPKERLPPAVECAAYSGPPRTDYRLQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W6QKT7</accession>
    <name>W6QKT7_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S05g000454</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QKT7"/>
    <dbReference type="STRING" id="1365484.W6QKT7"/>
    <dbReference type="OMA" id="SFCDLPY"/>
    <dbReference type="OrthoDB" id="74360at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050982">
        <property type="entry name" value="Auxin_biosynth/cation_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43539">
        <property type="entry name" value="FLAVIN-BINDING MONOOXYGENASE-LIKE PROTEIN (AFU_ORTHOLOGUE AFUA_4G09220)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43539:SF68">
        <property type="entry name" value="FLAVIN-BINDING MONOOXYGENASE-LIKE PROTEIN (AFU_ORTHOLOGUE AFUA_4G09220)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13738">
        <property type="entry name" value="Pyr_redox_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="557"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="569"/>
            <end position="583"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM36621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="663" mass="72787" checksum="4829CBE1107C5F07" modified="2014-04-16" version="1">MAANNMSLSRDEFPPRIDLLKLMAQNPLPLLAPGMVDPVSMADYEPTKQTQLVLDNLNTALARNDAGALEDCFWKDQAYWRDQLALTYHLRTFKSPGIIAASLLETNKLRAIKGDITVDGGAIFIQATPVLQFIDCGIAFQTSSPAATCKGKVILLPVKGANEIIEWKIWVLSTILKDLDIQKENETLLHSPGRQFGGIESFETEVFIIGGGNSAIALAARLKALGVESVMAERNVHAGDNWALRYDSMRFHVLTSLCHLPYMDYDQKLLTPHRLSKEDLASQVRQYVKAFNLNIITSAQIQWTEYDPSTKRWIVKFQTPAGQRKAISKHVILATGIASQKVNIPSIADSYLYKGTSIHSEQYKNAEQVKEKGAKSVIIIGSANTAFDILEDCHAAGLQVTMNVRSPTYIVPVDYVNNPASLGAYDASVELADNCFMTIPTVIDAQFARNLFSHFASQEPDRYKALAAAGFPVLDSNNPECALMQNLIERAGGHYVDVGGTKLLEEGKAGIKANVEPVAYTATGLRFSDGSHVEADAVIWCTGFVDKNVRETAAEILGGSPGQAPNGAEDDKNSVDGEADSKQKLGPRQIAARIDATWGVDSEGEIRGLWKRQSRLHGFWVMGGYTQQHRWHSRTLALQLKADLEGILPPAYLDTPTLTSEWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W6QL88</accession>
    <name>W6QL88_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Tat pathway signal sequence</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S02g000446</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ustYa family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QL88"/>
    <dbReference type="STRING" id="1365484.W6QL88"/>
    <dbReference type="OMA" id="NVEGFHH"/>
    <dbReference type="OrthoDB" id="3687641at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021765">
        <property type="entry name" value="UstYa-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365:SF13">
        <property type="entry name" value="TAT PATHWAY SIGNAL SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365">
        <property type="entry name" value="YALI0B05434P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11807">
        <property type="entry name" value="UstYa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="43"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00035112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM30297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="284" mass="32389" checksum="32C7E681D0E536FA" modified="2014-04-16" version="1">MDSIFDKNCHGDYSRRESGEGLLAEEEGTLWNRKETPTPTCNSFAVCLFQLSALVLVFLVGTLFGFHWRGDLDGLCSRHVSQYSTVMKEVGIQYSLQEFNGSLLKENVFRQDAGPDVDAAWESLGVNYRSIRVPPEDAEKSGLANDQVKINAKYGGGFPANVEGLHHLHCLNLLRQSLYYNYDYYHAKGEGPFTNNDYILRRHVSHCLDIVRQELMCTVDSGVLGQVWIYPENPEPYVDFNTQHRCKNFDAVRRWAEDNQLPQDPPSDFLQPPSEGDRIYIQMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2024-10-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>W6QLD9</accession>
    <name>W6QLD9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S06g000206</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792020">
        <property type="protein sequence ID" value="CDM37245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QLD9"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM37245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="86" mass="9531" checksum="91F1E4D708323463" modified="2014-04-16" version="1">MSSSEITRLSLFRPASPMVYGLMSRYLHDLGYELCRHPHTTSLGRPESGAPAVILLIPFPIVQDLTKDNTITRASESRAGLELEFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>W6QLP2</accession>
    <name>W6QLP2_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">Phosphoribosylaminoimidazole carboxylase</fullName>
            <ecNumber evidence="4 11">4.1.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">ADE2</name>
        <name evidence="14" type="ORF">PROQFM164_S05g000734</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + H(+) = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + CO2</text>
            <dbReference type="Rhea" id="RHEA:10792"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:77657"/>
            <dbReference type="ChEBI" id="CHEBI:137981"/>
            <dbReference type="EC" id="4.1.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (carboxylase route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">In the C-terminal section; belongs to the AIR carboxylase family. Class I subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.21" evidence="4 11"/>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QLP2"/>
    <dbReference type="STRING" id="1365484.W6QLP2"/>
    <dbReference type="OMA" id="ITFDHEH"/>
    <dbReference type="OrthoDB" id="15425at2759"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00130"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004638">
        <property type="term" value="F:phosphoribosylaminoimidazole carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.20:FF:000030">
        <property type="entry name" value="Phosphoribosylaminoimidazole carboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000016">
        <property type="entry name" value="phosphoribosylaminoimidazole carboxylase, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01929">
        <property type="entry name" value="PurE_classI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01928">
        <property type="entry name" value="PurK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016301">
        <property type="entry name" value="Ade2_fungi/plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003135">
        <property type="entry name" value="ATP-grasp_carboxylate-amine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033747">
        <property type="entry name" value="PurE_ClassI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000031">
        <property type="entry name" value="PurE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005875">
        <property type="entry name" value="PurK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040686">
        <property type="entry name" value="PurK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054350">
        <property type="entry name" value="PurT/PurK_preATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004679">
        <property type="entry name" value="PRK06019.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01162">
        <property type="entry name" value="purE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01161">
        <property type="entry name" value="purK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11609:SF5">
        <property type="entry name" value="PHOSPHORIBOSYLAMINOIMIDAZOLE CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11609">
        <property type="entry name" value="PURINE BIOSYNTHESIS PROTEIN 6/7, PUR6/7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00731">
        <property type="entry name" value="AIRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02222">
        <property type="entry name" value="ATP-grasp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17769">
        <property type="entry name" value="PurK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22660">
        <property type="entry name" value="RS_preATP-grasp-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001340">
        <property type="entry name" value="AIR_carboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01001">
        <property type="entry name" value="AIRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52255">
        <property type="entry name" value="N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="Rudiment single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 11" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="10 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 11 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 11" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="13">
        <location>
            <begin position="108"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR001340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDM36901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="572" mass="62196" checksum="3AFABF40314A5795" modified="2014-04-16" version="1">MWNSPKVGILGGGQLGRMLVESANRLNIQVNILDVDNSPAKQISSHDGHVTGSFKEPDAVRKLAETCDVITAEIEHVDTYALEEVASKVRVEPSWQAIRTIQNKFNQKEHLRKYGIPMADHRELVDNTPEELAQIGEQLGYPMMLKSKTMAYDGRGNFRVNSKEDIPEALEALKDRPLYSEKWAYFKMELAVMVIKTKDDVLSYPTVETVQEDSICKLVYAPARNVPEAINQQAQALARKAVSAFEGKGAFGVEMFLLEDNSLMLCELASRIHNSGHWTIEGCALSQFDSHIRAILDLPIPPKSLELRQPSIMLNIIGGATPDSHLKATEAALSIPNASIHLYSKGAARPGRKMGHVTVTAATMHEAETLIQPLIDVVDTMRAQRSDIKTKAAPSGPSKPVPSVAVIMGSDSDLKTLVPGLKLLRDYFGIEPEVEITSAHRTPDYMAEYAGQAASRGIKVIIAAAGGAAHLPGMAAAHTALPVIGVPVKGSSLDGVDSLYSIVQMPRGVPVATVGINNSINAALLAARVLGSFDPAIQRKVEAYAEAARAENMELKGTKLRELGWQKYFDQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W6QLY3</accession>
    <name>W6QLY3_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PROQFM164_S07g000171</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792021">
        <property type="protein sequence ID" value="CDM37823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QLY3"/>
    <dbReference type="STRING" id="1365484.W6QLY3"/>
    <dbReference type="OMA" id="MSCANTG"/>
    <dbReference type="OrthoDB" id="5086884at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17325">
        <property type="entry name" value="MFS_MdtG_SLC18_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050930">
        <property type="entry name" value="MFS_Vesicular_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23506">
        <property type="entry name" value="GH10249P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23506:SF35">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="64"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="119"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="153"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="244"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="279"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="313"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="423"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="22"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM37823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="448" mass="47524" checksum="5A4D6F8B209C1654" modified="2014-04-16" version="1">MTVITEKTLPIGYNWRSSKWFILSTIAIALFAETFLYGFLVPILGEMLRDRLHVPPSQAQELTSAALALHGTLAMVSGPIIGHFADKNTGRKTALLLSLGWCIVGTCMVAGAHSVPILLLGRVLQGIAGSAVWIVGFATVADTVSPSRIGFAMSLMMSCANTGVISGPAIAGLLIEATGYWITWSIPLVVLTIDFIARVCMIESPSSPPSMPTETASLLSSCEEQQIPSRNDSFWRTMLCNGRVGTCLLIIISGTTVSTSFHATLPLHVEETFGWGPRAVGFLFAGLVIPGVVIGPIAGWVRDKVGTRRPTMVCAVLEAIVLGLMGIAGDIPWAGARNMGKPLYVACIVAIGILRPFVSGIAPVELTATAKAIQEQSPGTFGPKGGMSRVFSMMDVADSLGMMIGPIIGGSLKEMVGYKCMSWTWSLLYLLLAALAMVFLGSEDAEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2024-10-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>W6QNE8</accession>
    <name>W6QNE8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S04</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S04g000525</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QNE8"/>
    <dbReference type="STRING" id="1365484.W6QNE8"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM35644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="111" mass="12383" checksum="D472BF134BEBB227" modified="2014-04-16" version="1">MSIRLASLATLSRQIFANTSKDIRTHPTINLPDYFDSITARWETIGLVFALLGTALFHTPEDDPVFTHRNPWKLAKSNLRNTATAIGNICCELCNGVGTISDPFCWLMTQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W6QNI3</accession>
    <name>W6QNI3_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F-box domain, cyclin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S02g001357</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QNI3"/>
    <dbReference type="STRING" id="1365484.W6QNI3"/>
    <dbReference type="OrthoDB" id="5279008at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM31207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="51" mass="5948" checksum="0A29100A4E8ECFF2" modified="2014-04-16" version="1">MSITNLPPEILSHICEYLEPQEWGALRITCHQIHGSTLEAYATRYFNCIPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>W6QNR2</accession>
    <name>W6QNR2_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pre-rRNA-processing protein ESF2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">18S rRNA factor 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Pre-rRNA-processing protein esf2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">esf2</name>
        <name evidence="10" type="ORF">PROQFM164_S02g001392</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in the small subunit (SSU) processome assembly and function, and in the 18S rRNA synthesis. Required for the early cleavages at sites A0, A1 and A2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ESF2/ABP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QNR2"/>
    <dbReference type="STRING" id="1365484.W6QNR2"/>
    <dbReference type="OMA" id="TRKHNDF"/>
    <dbReference type="OrthoDB" id="287393at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000480">
        <property type="term" value="P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034462">
        <property type="term" value="P:small-subunit processome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12263">
        <property type="entry name" value="RRM_ABT1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039119">
        <property type="entry name" value="ABT1/Esf2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034353">
        <property type="entry name" value="ABT1/ESF2_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12311">
        <property type="entry name" value="ACTIVATOR OF BASAL TRANSCRIPTION 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12311:SF7">
        <property type="entry name" value="ACTIVATOR OF BASAL TRANSCRIPTION 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="281"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="53"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="96"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="289"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDM31242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="336" mass="37785" checksum="A7D2459A6A3D73C4" modified="2014-04-16" version="1">MTTRKHNDFLDIAADDDEASGSDRGYDSEANVVESKGRAVKRRRTTTTQDFSQESDEDEDEEENDKDAENEDEDNHNEDGGTSPKDPAQPSTKSAKSLKAKGKLAKLSKLANGKEPKKKRSGVIYFSSLPPYLKPFALKAMLEKRGFGGITKIFLAPLLPSAAGHRNRSNKRKLYTEGWIEFDSKKTAKICAETLNATIVGGLKSSWYHDDVWNIKYLSRYSWEDLMQSVQRERSERESKRKIADARESKEAKMFIAGVESGRIADGMAKKNEEKMKRRLEAAGEAAGDGDKELLQPKKDKQPTRRRFHFQQNEVVKGSKDGAMAEDAKRVLGKIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W6QNT2</accession>
    <name>W6QNT2_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Heat shock protein Hsp70</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S08g000116</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792022">
        <property type="protein sequence ID" value="CDM38065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QNT2"/>
    <dbReference type="STRING" id="1365484.W6QNT2"/>
    <dbReference type="OMA" id="MGRCTSR"/>
    <dbReference type="OrthoDB" id="2963168at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10170">
        <property type="entry name" value="ASKHA_NBD_HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187">
        <property type="entry name" value="ALPHA KINASE/ELONGATION FACTOR 2 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187:SF79">
        <property type="entry name" value="HSP70 FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_1G15200)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="21"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="34"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="78"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM38065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="698" mass="77588" checksum="9411F33B511C4B48" modified="2014-04-16" version="1">MDLMSSRFKSFGFRNKKSPPNSNPIVPPTPSSPPSSSSTTSLPMNHQQTQPQLGRPPSYTNNRPTSPMAHGQQPPPITTNLQYNSNAPLNGPPGYGMQQQQMAPSIPPSLSNTQYPGRNPAVEVEGGGRSKAQLIVGIDFGTTFSGVAYAFATNNQASEDIITEWPGAGTHAKQKIPTVLYYDQYQKVVGWGPDIADALAPTGYPKPQVQKVEWFKLQLMLSGNTYIDPINLPPLPPGKSEIDVAADYLFKLRQAIRANLQKALGEVFTREERNIRYYLTVPAIWNDAGKAATRTAAIQAGFLRDENDNRLTLVSEPEAAALFCAKSGLLNLKVGDAILIVDCGGGTVDLIAYEVEEESPFSVMECTAGSGDSCGSTALNRNFSNILRAQIRKMKLPDGSRTAGKVYAKCIMDFENRIKADFRNNGQKWAVDVGIEADFPDAGIEEGYMTFTNEEILQCFEPVVNRILELVRNQIIAIQAQNRLLQNVLVVGGFGASEYLFQQIKLHVPPQYQTKVVRPMDSVAAIVKGAVTAGITERVITHRVARRHYLMATLQPFKEGYHPEQYRVPSLDGRDRCKYTRQIFVQKGERVRIGEPVKVSFFRQVAPGATLMYEDVLYACDEDVCPEYTKDPRIKELVTLTSDLSRKNLETDFERMDTPQGIFYRVYFDIYLTLDGSEFSAELVCQNEIMGRCRAKFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W6QNT3</accession>
    <name>W6QNT3_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BCS1, N-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S29g000005</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792043">
        <property type="protein sequence ID" value="CDM38599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QNT3"/>
    <dbReference type="STRING" id="1365484.W6QNT3"/>
    <dbReference type="OrthoDB" id="10251412at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014851">
        <property type="entry name" value="BCS1_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08740">
        <property type="entry name" value="BCS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BCS1 N-terminal" evidence="1">
        <location>
            <begin position="7"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM38599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="50" mass="5867" checksum="0E2F2D150071558B" modified="2014-04-16" version="1">MSLIDILFPSLTSTIHISYYNEAYDMLVDWIAYQPFVYNAHTLIARVRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W6QP44</accession>
    <name>W6QP44_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Short-chain dehydrogenase/reductase SDR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S02g001507</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QP44"/>
    <dbReference type="STRING" id="1365484.W6QP44"/>
    <dbReference type="OMA" id="VWDTTMA"/>
    <dbReference type="OrthoDB" id="5840532at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24321">
        <property type="entry name" value="DEHYDROGENASES, SHORT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24321:SF12">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G14340)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM31357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="268" mass="28135" checksum="2547B5EC7736C0AF" modified="2014-04-16" version="1">MAYNMFPGVAVITGAGGTGIGAATAKAFAAAGCERIAITDLNEKSLQTTAKAIASTYPKTQLLVKAGNVADDQFADSFIDAVVQQFGRVDYAVNCAGVLGKSLRSAETSLEEFDRVNNINYRGCWLSSRAELRQMVSQSELPSHDPNRPGQRGAVVNVASQLGIVSRPGAPAYCASKSAVIGMTRADGIDYSKDGIRVNCVCPGVIETPLIMENPEIRAAITPAAEIAPMKRMGQPAEVADAILFLCSTQASFVQGHAMVVDGGYITV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W6QP76</accession>
    <name>W6QP76_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="5">10 kDa heat shock protein, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">HSP10</name>
        <name evidence="5" type="ORF">PROQFM164_S02g001542</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Eukaryotic CPN10 homolog which is essential for mitochondrial protein biogenesis, together with CPN60. Binds to CPN60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the GroES chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QP76"/>
    <dbReference type="STRING" id="1365484.W6QP76"/>
    <dbReference type="OMA" id="EDFLIMR"/>
    <dbReference type="OrthoDB" id="184876at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00320">
        <property type="entry name" value="cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.33.40:FF:000002">
        <property type="entry name" value="10 kDa chaperonin, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.33.40">
        <property type="entry name" value="GroES chaperonin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00580">
        <property type="entry name" value="CH10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020818">
        <property type="entry name" value="Chaperonin_GroES"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037124">
        <property type="entry name" value="Chaperonin_GroES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018369">
        <property type="entry name" value="Chaprnonin_Cpn10_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10772">
        <property type="entry name" value="10 KDA HEAT SHOCK PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10772:SF0">
        <property type="entry name" value="10 KDA HEAT SHOCK PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00166">
        <property type="entry name" value="Cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00297">
        <property type="entry name" value="CHAPERONIN10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00883">
        <property type="entry name" value="Cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00681">
        <property type="entry name" value="CHAPERONINS_CPN10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0346">Stress response</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00056825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDM31392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="103" mass="11204" checksum="B90FE1A6671F4F4F" modified="2014-04-16" version="1">MSVLRNIKSLAPLLDRVLVQRIKPEAKTASGIFLPEAAVKEQNEAQVLAVGPGLLDRDGKRLPMGVSAGDKVLIPQFGGNAIKVGEEEYTLFRDHDILAKIKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2024-10-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>W6QQI4</accession>
    <name>W6QQI4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S02g001938</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QQI4"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM31787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="59" mass="6848" checksum="073B217B8DD226A4" modified="2014-04-16" version="1">MQLCIHTTCLFIEIYEYLNVPACPDMYSIYMVVYPPKQTRGSMAMQTEYGSKQRELCAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W6QQR0</accession>
    <name>W6QQR0_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S02g002038</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QQR0"/>
    <dbReference type="STRING" id="1365484.W6QQR0"/>
    <dbReference type="OMA" id="IPYLQEC"/>
    <dbReference type="OrthoDB" id="4312812at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM31887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="491" mass="56398" checksum="F9A72C444156C268" modified="2014-04-16" version="1">MQSTSPEESVFGPPPQTLDMQYSLFKEMNMSAQSRIGASDWGHSYPAIFQLDLEIPAFFIPYRWWEDEATTVFWAFDIQEIKRVIQFGLFCDPNFPRSSLCTRNVDTIETFLSALSEPYESQLLGSLSHIQRVEEILRRSSISPFQEMPWSWLPPQSSPTLDARAIAAAIEAESHFQFRQIPFEEFVRAALGYNAVFVEWFLQQHAALYIMLQDHLGVYPEDIPLYTEVEKYLRSGSPFAHRALVKCLLAVRPGANHDLPQPNTAGFEFIAGPIQALFKDQPGRLTAMLKMLTVLTIRYRRQYIHTPIMDWQTPFDTSLPFLDDCLQSTSPKDLADSMRGLDEHQFAELTQQSLITEDFIVEQLKVQWRELSVSVWECCAALPDLIPYLQECTQFLLATRDYHSFTAIIKGLHIYTILTSRPGNIQGNPITLEALIPREIVSLMSPADNFAVYRQHYQNFPGIPWLVPHLRDHKENGEAVLQPVFHYLQST</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W6QR79</accession>
    <name>W6QR79_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S02g002203</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QR79"/>
    <dbReference type="STRING" id="1365484.W6QR79"/>
    <dbReference type="OrthoDB" id="3800738at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM32052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="62" mass="6957" checksum="E696B142C50454D6" modified="2014-04-16" version="1">MAPATRSAARKAFIVSTLTPPALKTPEVLEMILLQTNMRTLLTSCLYVCWDWHNLIIKSPSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W6QS09</accession>
    <name>W6QS09_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cation efflux protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PROQFM164_S05g000722</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QS09"/>
    <dbReference type="STRING" id="1365484.W6QS09"/>
    <dbReference type="OMA" id="QKVDTCR"/>
    <dbReference type="OrthoDB" id="78296at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098771">
        <property type="term" value="P:inorganic ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030003">
        <property type="term" value="P:intracellular monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1350:FF:000001">
        <property type="entry name" value="Metal tolerance protein 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1510.10:FF:000005">
        <property type="entry name" value="Putative Cation diffusion facilitator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1350">
        <property type="entry name" value="Cation efflux protein, cytoplasmic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027470">
        <property type="entry name" value="Cation_efflux_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050291">
        <property type="entry name" value="CDF_Transporter"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43840:SF13">
        <property type="entry name" value="CATION EFFLUX PROTEIN CYTOPLASMIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43840">
        <property type="entry name" value="MITOCHONDRIAL METAL TRANSPORTER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16916">
        <property type="entry name" value="ZT_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="Cation efflux protein cytoplasmic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="142"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="235"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="8">
        <location>
            <begin position="76"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein cytoplasmic" evidence="9">
        <location>
            <begin position="283"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDM36889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="391" mass="44235" checksum="FEC29A6E30A6A6F1" modified="2014-04-16" version="1">MTLLHDPLNLNQYKTTISEPKKNWVPISFSDEKEKLTGFYKEQNEMIEGFLTAGEEERLKAEDEAQNGGKVKLAVRASFTVNFFLFVIQLYAAVTTGSLALFATAADAFMDLVSSVVMLVTSRMSSRPKPYKYPVGRRRVETMGVIMFCALMTIVAVELIIESAKALAAGKTESEQLDLVPLVCVGVAIFSKFCMFLYCYGLRRYPAAHVFYIDHRNDLAVNGFGLIMSIVGDRFVWYLDPIGACCIALLILFSWASTAFDNMWLIVGKCAPREFLNKCVYVTLTHDQRIQKVDTCRAYHSGQQLYVEVDIVMDPETKLRESHDVSQALQRKLEGLADVERAFVHVDYDYEHDVNEEHRPLYEIGGSKHSIRALVKRLWSRNEDKADGTAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2024-10-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>W6QTH5</accession>
    <name>W6QTH5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S06g000411</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792020">
        <property type="protein sequence ID" value="CDM37449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QTH5"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM37449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="101" mass="11716" checksum="B6F66B68AD2D8356" modified="2014-04-16" version="1">MTTRRILQTTRHLPIYSQFARPSVTRPTFFRFPFEPPSRLAKSLSTSHFNTIRSLSTSTTMASRSKRDPTMYSFMNGADLVEELLRSRNFLRRMDSQHGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W6QTQ4</accession>
    <name>W6QTQ4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Metal-dependent hydrolase, composite domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S02g003073</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QTQ4"/>
    <dbReference type="STRING" id="1365484.W6QTQ4"/>
    <dbReference type="OrthoDB" id="5595695at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM32922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="101" mass="11082" checksum="2B51C5DC2DDB1896" modified="2014-04-16" version="1">MAQNLPSSDIKPWTRPAPKGYKFTNAHIVDVASGTIIENQTLIATDGKITYLGQESSAPTELETVDCQGKYLSLGLFDVYIHLYAILGFSDLSKAFENLNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W6QTU5</accession>
    <name>W6QTU5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">F-box domain, cyclin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S06g000531</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792020">
        <property type="protein sequence ID" value="CDM37569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QTU5"/>
    <dbReference type="OMA" id="MEMCNPL"/>
    <dbReference type="OrthoDB" id="4326814at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="533"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="533"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM37569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="565" mass="64129" checksum="956CA179528051CD" modified="2014-04-16" version="1">MSITILPPEILSHICEYLEPQEWGALRITCHQIHGSTLEAYATRYFNSYATRYFKILSLLLTRESLDNLEDIAESETLRGSVREIRIIPNLFEGWPEKNKERFRSPGLALRQQRSIFRIMRGEKEEPPFNKTEAKAELDALFTSYQAALEEHRAILDSELTAVLEKCLPRLENATTVGLRCYPIEFLLEANYRSFRCLGLRELKNQFNNDDISVHLTFTSFQRKMLSMPLALAFSQMVKAIIKSSHKVRALHTCGNIACGMKLGSIKLSESQYQSLLSLLTDLTTLHMCIRIKDNENDTFDEDAFKHLLSILVTVAPKLKVLTFAQWSPLEELSPLYFQDLSQNIRFSQLEELHLHSIELTVGNLKRFLQTAAPTLRRLSMKNVSLTDAIIGAQDPGPLTEERSSWGSSLSLEVINKIQELWKRSFELLADSPKLQFVQLSSLGYRGREIILQDDLYIERGQPDAQPDSNARRSINWPEICSDPTRGQSSLIDFYFDAGRANISLKRWIMQLRMEMCNPAGLATTQLPGTSGLSFNQDGVGSSTTYQPGEGPDPRRLAEMGALVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W6QVJ3</accession>
    <name>W6QVJ3_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Eukaryotic translation initiation factor 4E-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">tif451</name>
        <name evidence="10" type="ORF">PROQFM164_S09g000060</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">eIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least eIF4A, eIF4E and eIF4G. eIF4E is also known to interact with other partners.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the eukaryotic initiation factor 4E family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792023">
        <property type="protein sequence ID" value="CDM38144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QVJ3"/>
    <dbReference type="STRING" id="1365484.W6QVJ3"/>
    <dbReference type="OMA" id="EEFWAIV"/>
    <dbReference type="OrthoDB" id="590761at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016281">
        <property type="term" value="C:eukaryotic translation initiation factor 4F complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000340">
        <property type="term" value="F:RNA 7-methylguanosine cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.760.10:FF:000004">
        <property type="entry name" value="Eukaryotic translation initiation factor 4E-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.760.10">
        <property type="entry name" value="RNA Cap, Translation Initiation Factor Eif4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023398">
        <property type="entry name" value="TIF_eIF4e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001040">
        <property type="entry name" value="TIF_eIF_4E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019770">
        <property type="entry name" value="TIF_eIF_4E_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960:SF8">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01652">
        <property type="entry name" value="IF4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55418">
        <property type="entry name" value="eIF4e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00813">
        <property type="entry name" value="IF4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 10" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="6 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0810">Translation regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00062860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDM38144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="238" mass="26708" checksum="9EAE32768228FFE3" modified="2014-04-16" version="1">MAAVAENGTPAVADENSAPVTETQTGDAVTVFHNPDDFNVKHPLMHEWTLWFTKPPSGKGDNWNDLLKEVVTFSSVEEFWGIYNNITPTSELGLKADYHLFKKGVRPEWEDPQNKHGGKWSYQFKDKRSVPIDELWLHAQLAAIGETLENDDDNEVMGVVVNVRKGFYRVGLWTRTVGKSIQGDKHTRTQAQGKEILEAIGQRFKDVLRLNLADVVEFSGHTDSAHSGSTRAKAKYTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W6QW28</accession>
    <name>W6QW28_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tyrosine-protein kinase, catalytic domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S11g000017</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792025">
        <property type="protein sequence ID" value="CDM38314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1365484.W6QW28"/>
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    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044773">
        <property type="term" value="P:mitotic DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167">
        <property type="entry name" value="OVARIAN-SPECIFIC SERINE/THREONINE-PROTEIN KINASE LOK-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167:SF24">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE CHK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Protein kinase-like (PK-like)"/>
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    </dbReference>
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        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="16"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM38314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="266" mass="29753" checksum="E594A44699BC6390" modified="2014-04-16" version="1">MLDDAEVVIYRHYCPPGVKKVIASGSSAFIGEVDDLTVMKYPLAPGGDMSRLEIEKKLFEIVGSHERIIGFRGFSDKGLYLERAVNGTLGYYLLESDNAPPSIQQQLSWCREATEAVAWIHAQGVIHCDIQPGNILLDEDLHIKLSDFQGKQLSSDGTVLLDGGSGEPVRFYCPRADPFDADVKTDLFALGCTIYLIMMGYSVFPDIVDGEDGWYEQRFEKQQFPRDSHACSAITWKCWLKEYESAEELLRDIEVVEKGLRTGPAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W6QWB3</accession>
    <name>W6QWB3_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S03g000511</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QWB3"/>
    <dbReference type="OMA" id="NCPNDSC"/>
    <dbReference type="OrthoDB" id="4341155at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004879914" evidence="1">
        <location>
            <begin position="17"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM33787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="280" mass="30532" checksum="8F343D010709DC46" modified="2014-04-16" version="1">MSSFVYIFALVPLALAASMIRMVPNQAMILKEHDFAINAGRKGVLIASDGNCMDLDNISDYDNSCNNELFTFTRPHANLFRPAVGDSVGRHVRSIKCTTVHSPADRQEHVFSSDHASAKSPSNCPNDSCSSELDCQSNHPDYGMYCSSSSLTCQRTSETGRHCEGDSRCSGGNCSSGECMTVAENSRFLQGSECPSGMQCRPTHFHWSGASNVEMVCMKDEDARGIQCSAERPCQEHMPCVLRHETSTYCEWNGTCGLNTMSCESGSQCCSGFCKANLCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W6QWF5</accession>
    <name>W6QWF5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="4">60S ribosomal protein L22</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpl22</name>
        <name evidence="4" type="ORF">PROQFM164_S03g000566</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL22 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QWF5"/>
    <dbReference type="STRING" id="1365484.W6QWF5"/>
    <dbReference type="OMA" id="YQLRFYN"/>
    <dbReference type="OrthoDB" id="10259820at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1360.210:FF:000001">
        <property type="entry name" value="60S ribosomal protein L22 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002671">
        <property type="entry name" value="Ribosomal_eL22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038526">
        <property type="entry name" value="Ribosomal_eL22_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10064">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10064:SF31">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL22A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01776">
        <property type="entry name" value="Ribosomal_L22e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM33842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="124" mass="14145" checksum="6314645E17E1F0DD" modified="2014-04-16" version="1">MAPAAARGRKAQKVTQKFVINASQPASDKIFDVSAFEKFLHDRIKVEGRVGNLGENVVISQIGEGRIEVVAHIPFSGRYLKYLTKKYLKKQQLRDWLRVVSTSKGVYELRFYNVVNDEAEDDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W6QXJ9</accession>
    <name>W6QXJ9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="10">GRIP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PROQFM164_S03g000976</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QXJ9"/>
    <dbReference type="STRING" id="1365484.W6QXJ9"/>
    <dbReference type="OMA" id="NIGQDHV"/>
    <dbReference type="OrthoDB" id="1926336at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051952">
        <property type="entry name" value="Golgi-autophagy_related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000237">
        <property type="entry name" value="GRIP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23157">
        <property type="entry name" value="GRIP AND COILED-COIL DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23157:SF25">
        <property type="entry name" value="GRIP AND COILED-COIL DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01465">
        <property type="entry name" value="GRIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00755">
        <property type="entry name" value="Grip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90257">
        <property type="entry name" value="Myosin rod fragments"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50913">
        <property type="entry name" value="GRIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="38"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="GRIP" evidence="9">
        <location>
            <begin position="1159"/>
            <end position="1209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="83"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="294"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="432"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="558"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="995"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1098"/>
            <end position="1161"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="199"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="785"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="883"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="174"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="294"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="432"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="463"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="561"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="587"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="995"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1015"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1098"/>
            <end position="1124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1125"/>
            <end position="1144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDM34252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="1213" mass="137171" checksum="53E3EEB788FFD42E" modified="2014-04-16" version="1">MAKKVETAQVDLPHGKFPPWLRFQPWKPMLPLTSFCGLLFFLFLVNTLASGLAFLDSVVVWVLRTAAMFQRLRDAIDSRIAEEQARQKSAQDNIERSNSARRPPGRNQSPSRRARPRRNTGTPVRGPDPKEFEAEFTIGDDESIRSGTPRADTPEPASEVSAPNEGESQMAEGKPAETPEKETGETETKEAPAVLPPDVRAKLRRLDKLESRYHELLKAYRTAHSRVLSIEPFEAALRENTPLTSIGEPKAFTEYLNQSTLKSDMVMDELKRVTEEREDFRKKFEEAQQATKEALDELTGLKKEKPQTETPIGTDGTGEQASEEFFSFDNEVPRLEGELKEKKEEVENLKTEVEKLKRDMSVTRESTEGMVQNLETATRELVELRETKDNLDAEIKTLQTSKKADVDDLKAKLATAESSLKSTTLEVEKFKSQLKEKSEEIDKLQKQASERTESDSTLAAELETTKEEKKSDEKKLVVLQGLVDSLRSQLKDTESTVLQLKTEIDERCEHSAKLQDIFDLVDENLKENKAWVSTKEKVFVGELADFNEVIKTLVPVKEEPNSTVSAPVTTEGETQPAQATGGGSSGGKKKNNKKKKKGGKAEEPSKSTDAAPAEQPPPEAPSTATKELDELKQKIESLTLQLSEKEAAIDRLSSKLKSEDNLKEEIESLRDDLINIGQGHVAAKDKIKDLSEERTSLQETISKLEKELAELRTSNASTSADSAKVHTSLKEEFDNLKVRSVTLETDLSAAQQLAATRFKDLTDLRETLQKVQPELRSLRAESSELKTLKETLASKNSDLKVLEGKHENLCAELKTFKSRISERDAEVGTLTKKIRQETDSRLKAEEYLTVVQSNLRSAEGKKQDAINARDRTAAELSKTQDGLKNTRAKMREMDEHISQLNKELGSLREEIQLKTAQYTSAQSLMNSMRDQTTEVAMQMKEARERCESLDEELADAHRLLSERTREGETMRRLLNDIEGRSEAKVRDFKERMEAAVEERDRAEDEASTQGRRRAREMEELKAKVREAERALRTVEQDKEELEQSQKDWRRRRDELESVSEKSSQEVAEIRQAMAGLRDALDESEKQVRDLEKDKAELRRSVEETNSRLEKLRRSHKTLGEDVRLRGSPSGRPSSRSSTDSGSRRAVVSPGRSETPLGPPSNASIDYMYLKNVLLQFLEQRDKNYQKQLIPVLGMLLHFDRNDEQKWMSAIMSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W6QXW6</accession>
    <name>W6QXW6_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tafazzin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S03g001101</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QXW6"/>
    <dbReference type="STRING" id="1365484.W6QXW6"/>
    <dbReference type="OMA" id="GTNYYSH"/>
    <dbReference type="OrthoDB" id="193467at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="52"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="101"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM34377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="547" mass="60405" checksum="B0A461974AFEF88D" modified="2014-04-16" version="1">MPKKHQRFHAKPANLAHHSLALSGSRHDGGSGVQGSASATSVNDLISHLRRTQTPSASSDDPPSSQRARRSFVAPRSVHPSLRDVLELPATAPPRPRPGPRRTVFGVRPTRPTVGPPPPASWLAGNTNPAGDQGSHHRMPESSEEEIHRLARLPGPLFPDHRSLVHLVLKTMALNWCWHLEYDGPFLAHLPNHIKELLLSYVAVYARGPPLRGYMKGLKPLFLTRHDQDQIGKEVPGFNESGAIDGDFKIVRLDLGNALGNWITLKQLTNEVTISQAPVVGVSGHETEEIIPASWDEDVYNGREEAMVDRLSTPSIPKAISQTLRFPQLRALSLAHPTPSAASWTALLNLLAHLPTLTHLSLAHWPIPCRNPSAATTRIRSSVARFLAPDALDNNWAEAASILRQLSRSTYCLKWLDLEGCGEWLPALKWVGKDPDGVPQSPDTVGPEWNRSWRDVEWLGIGPGFLDLTESHDSSHVPSHEVPTPQTGLPNSSVHAYHLQNARDVLKHIRQIRRGKKWLEIELGSGLKDVEPETIRSLDGQELLVYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>W6QYF5</accession>
    <name>W6QYF5_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">sterol 14alpha-demethylase</fullName>
            <ecNumber evidence="12">1.14.14.154</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="28" type="primary">CYP51</name>
        <name evidence="28" type="ORF">PROQFM164_S03g001306</name>
    </gene>
    <organism evidence="28 29">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="28" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="28">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>32-hydroxyeburicol + reduced [NADPH--hemoprotein reductase] + O2 = 32-oxoeburicol + oxidized [NADPH--hemoprotein reductase] + 2 H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:75431"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:194328"/>
            <dbReference type="ChEBI" id="CHEBI:194329"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:75432"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>32-hydroxylanosterol + reduced [NADPH--hemoprotein reductase] + O2 = 32-oxolanosterol + oxidized [NADPH--hemoprotein reductase] + 2 H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:75107"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:166681"/>
            <dbReference type="ChEBI" id="CHEBI:166806"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:75108"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>32-oxoeburicol + reduced [NADPH--hemoprotein reductase] + O2 = 14-demethyleburicol + formate + oxidized [NADPH--hemoprotein reductase] + H2O + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:75435"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:194329"/>
            <dbReference type="ChEBI" id="CHEBI:194330"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:75436"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>32-oxolanosterol + reduced [NADPH--hemoprotein reductase] + O2 = 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + formate + oxidized [NADPH--hemoprotein reductase] + H2O + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:75111"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:17813"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:166681"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:75112"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>a 14alpha-formyl steroid + reduced [NADPH--hemoprotein reductase] + O2 = a Delta(14) steroid + formate + oxidized [NADPH--hemoprotein reductase] + H2O + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:68068"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:138031"/>
            <dbReference type="ChEBI" id="CHEBI:176902"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:68069"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a 14alpha-hydroxymethyl steroid + reduced [NADPH--hemoprotein reductase] + O2 = a 14alpha-formyl steroid + oxidized [NADPH--hemoprotein reductase] + 2 H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:68064"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:176901"/>
            <dbReference type="ChEBI" id="CHEBI:176902"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:68065"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a 14alpha-methyl steroid + 3 reduced [NADPH--hemoprotein reductase] + 3 O2 = a Delta(14) steroid + formate + 3 oxidized [NADPH--hemoprotein reductase] + 4 H2O + 4 H(+)</text>
            <dbReference type="Rhea" id="RHEA:54028"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:138029"/>
            <dbReference type="ChEBI" id="CHEBI:138031"/>
            <dbReference type="EC" id="1.14.14.154"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:54029"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>a 14alpha-methyl steroid + reduced [NADPH--hemoprotein reductase] + O2 = a 14alpha-hydroxymethyl steroid + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:68060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:138029"/>
            <dbReference type="ChEBI" id="CHEBI:176901"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:68061"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>eburicol + 3 reduced [NADPH--hemoprotein reductase] + 3 O2 = 14-demethyleburicol + formate + 3 oxidized [NADPH--hemoprotein reductase] + 4 H2O + 4 H(+)</text>
            <dbReference type="Rhea" id="RHEA:75439"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:70315"/>
            <dbReference type="ChEBI" id="CHEBI:194330"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="24">
            <dbReference type="Rhea" id="RHEA:75440"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>eburicol + reduced [NADPH--hemoprotein reductase] + O2 = 32-hydroxyeburicol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:75427"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:70315"/>
            <dbReference type="ChEBI" id="CHEBI:194328"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:75428"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>lanosterol + 3 reduced [NADPH--hemoprotein reductase] + 3 O2 = 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + formate + 3 oxidized [NADPH--hemoprotein reductase] + 4 H2O + 4 H(+)</text>
            <dbReference type="Rhea" id="RHEA:25286"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:16521"/>
            <dbReference type="ChEBI" id="CHEBI:17813"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="EC" id="1.14.14.154"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:25287"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>lanosterol + reduced [NADPH--hemoprotein reductase] + O2 = 32-hydroxylanosterol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:75103"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16521"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:166806"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:75104"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 25">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 26">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.14.154" evidence="12"/>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QYF5"/>
    <dbReference type="STRING" id="1365484.W6QYF5"/>
    <dbReference type="OMA" id="NFLMPWA"/>
    <dbReference type="OrthoDB" id="1055148at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008398">
        <property type="term" value="F:sterol 14-demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11042">
        <property type="entry name" value="CYP51-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000033">
        <property type="entry name" value="14-alpha sterol demethylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050529">
        <property type="entry name" value="CYP450_sterol_14alpha_dmase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24304:SF2">
        <property type="entry name" value="24-HYDROXYCHOLESTEROL 7-ALPHA-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24304">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 25 26" id="KW-0349">Heme</keyword>
    <keyword evidence="9 25 26" id="KW-0408">Iron</keyword>
    <keyword evidence="11 27" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 25 26" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="28" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10 26" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="8 26" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="28" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 27" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 27" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="27">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="27">
        <location>
            <begin position="44"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="25">
        <location>
            <position position="460"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00049163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00049450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00051540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00051806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00052067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00052625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="EMBL" id="CDM34582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="516" mass="58283" checksum="CFB73EE0DEFE50F8" modified="2014-04-16" version="1">MDLVPLVTGQVLRAAYYTAGLVLVSIVLNVINQLVFYNRKEPPVVFHWIPFIGSTVAYGMDPYQFFFASRAKYGDIFTFILLGKKTTVYLGVEGNEFILNGKLKDVNAEEVYGKLTTPVFGSDVVYDCPNSKLMEQKKFIKYGLSQEALESYVPLIADETNAYIKSSPNFKGQSGTIDLAAAMAEITVFTAARTLQGEEVRAKMTSEFAELFHDLDLGFSPINFMLPWAPLPHNRKRDKAHGRMREIYLEIIQARREAGEQDNLTGRDKAKGTDMISNLMRCVYRDGTPIPDKEIAHMMITLLMAGQHSSSAISCWILLRLASQPEMTEKLYAEQIQNLGADLPPLQYKDMDKLPLHHNVIKETLRIHSSIHTLMRKVKNPMPVPGTDFVVPPSHVLLSSPGVTARDARHFRDPLRWNPHRWETRVEVEDSSDTVDYGYGAVSKGTRSPYLPFGAGRHRCIGEKFAYLNLEVIVATLVREFKFFNPEGMEGVPDTDYSSLFSRPMQPATVRWEVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W6QZ42</accession>
    <name>W6QZ42_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Probable transposable element</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S03g001524</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QZ42"/>
    <dbReference type="STRING" id="1365484.W6QZ42"/>
    <dbReference type="OMA" id="DEHYNRS"/>
    <dbReference type="OrthoDB" id="2196114at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00022">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1170.10">
        <property type="entry name" value="Inhibitor Of Apoptosis Protein (2mihbC-IAP-1), Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051190">
        <property type="entry name" value="Baculoviral_IAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001370">
        <property type="entry name" value="BIR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46771">
        <property type="entry name" value="DETERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46771:SF5">
        <property type="entry name" value="DETERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00653">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00238">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57924">
        <property type="entry name" value="Inhibitor of apoptosis (IAP) repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50143">
        <property type="entry name" value="BIR_REPEAT_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="200"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="203"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="256"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="277"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="307"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="378"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="445"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="475"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="498"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="511"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="564"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="612"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="661"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="706"/>
            <end position="718"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM34797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="855" mass="94574" checksum="BC6F1B93FAA2C934" modified="2014-04-16" version="1">MGSEMDTFAARLASFDLVLKPEKRRSSGTKTPKAITWPHQRPSPAELAHAGFYYKPYETNPDNTTCFQCHRALDGWEEDDNPITEHLKHAPDCGWAIMMDLQQSSSNPASIEDPTGDRITQARLATFGTVWPHDGKKGWVCQSEKMVEGGWYFCPTDESNDLASCVYCKLSLDGWEPKDDPFDEHYRRSSDCSFFVFAQPPGKKSKSARAKKPRVSKASSRLSTQSVGSVASEAPDMEVDDPMGQSIMSQSSTKSKSTKKAPKSKSKGTKTKKEEPAEVESQIDAEIEEVAQTEPVKPKRAGKGKKRTSEDIKDEPNPVAMEEKEPSQPPAEPPAKRRDTKTRSSSITRSYNYEHSDSAMADARPVDEATSEEETTRGRKPTRKRASKTRKVSDVPVASKAPSKARAPRDSEIEAEIEAGLEADIPTPAEPEPEIEAEPAEPRASKKTKSSKKSKAVARIPEATVHNQVEDVSDREDRSDPHVEPVDDEPEAPAPKTKLAKGSKKKGTKKIKTEETIKAQSPEPRESLGLRGPDVRDDSERHDSFVSVEIISKEPENAPEPEEPIAKAESKKISKKKDGTSTKEKKSKKSEKKAEQAPVLQPSVEEHRAEPSVEEQDDEFETTDDLPDQLEIVNPSPPQQISPEPQSHIKTPSLPPKTAKRYSDIPHEEHLAETLVQSQISPHEVHEPRRNSNRSNRAVSPLPPAHQNTPSPSPQSSDAENRPPSRPSASRAPVQPTPKQPEFRVPLAVSTPSPSKRNANGGFGPSGHPWTPVDIDEVLFGEASEKENADLSGLFRGAKASLTSPEKKMTVQEWIAWNAKNGEERLKRECERLVSQFEKEGGRAMRRLEAIECID</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W6R147</accession>
    <name>W6R147_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Histone-fold</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PROQFM164_S04g000438</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
            <location evidence="2">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the CENP-W/WIP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6R147"/>
    <dbReference type="STRING" id="1365484.W6R147"/>
    <dbReference type="OMA" id="YILFMQE"/>
    <dbReference type="OrthoDB" id="2543597at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051382">
        <property type="term" value="P:kinetochore assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13732">
        <property type="entry name" value="HFD_CENP-W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000075">
        <property type="entry name" value="WGS project CABT00000000 data, contig 2.56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052484">
        <property type="entry name" value="CENP-W/WIP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34832">
        <property type="entry name" value="CENTROMERE PROTEIN W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34832:SF1">
        <property type="entry name" value="CENTROMERE PROTEIN W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0137">Centromere</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="4" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor CBF/NF-Y/archaeal histone" evidence="8">
        <location>
            <begin position="9"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM35557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="78" mass="8930" checksum="E2FB04E539DF0B04" modified="2014-04-16" version="1">MAAAQKLYPRGTVKRIVKAHSNRSVSKNADILIFLDYMLFMQELMREASIQSRKSGEKNISANTVRKVTEKTLRKFQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W6R249</accession>
    <name>W6R249_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S04</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S04g000793</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6R249"/>
    <dbReference type="OMA" id="HKLQCQV"/>
    <dbReference type="OrthoDB" id="4331647at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM35912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="129" mass="14585" checksum="DF276824C2878385" modified="2014-04-16" version="1">MSTMDGSRVHPHNFREIYTKACEAFAHKLQCQVFVLLCPSPSPDMEEIPTRLDELGERVMQIGFLGEVGEVGVRDHNRVRVRWGSLPIKEICFQIKWELAVLKDEIAGGQTPPQLIAELLAEILDSLPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W6R280</accession>
    <name>W6R280_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Propionyl-CoA carboxylase beta chain, mitochondrial</fullName>
            <ecNumber evidence="2">6.4.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Propanoyl-CoA:carbon dioxide ligase subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PROQFM164_S04g000828</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>butanoyl-CoA + hydrogencarbonate + ATP = (2S)-ethylmalonyl-CoA + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:59520"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57371"/>
            <dbReference type="ChEBI" id="CHEBI:60909"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:59521"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>propanoyl-CoA + hydrogencarbonate + ATP = (S)-methylmalonyl-CoA + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23720"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57327"/>
            <dbReference type="ChEBI" id="CHEBI:57392"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.4.1.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:23721"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Metabolic intermediate metabolism; propanoyl-CoA degradation; succinyl-CoA from propanoyl-CoA: step 1/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">The holoenzyme is a dodecamer composed of 6 PCCA/alpha subunits and 6 PCCB/beta subunits.</text>
    </comment>
    <dbReference type="EC" id="6.4.1.3" evidence="2"/>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6R280"/>
    <dbReference type="STRING" id="1365484.W6R280"/>
    <dbReference type="OMA" id="ENTSYMF"/>
    <dbReference type="OrthoDB" id="439921at2759"/>
    <dbReference type="UniPathway" id="UPA00363">
        <property type="reaction ID" value="UER00861"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004658">
        <property type="term" value="F:propionyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006552">
        <property type="term" value="P:L-leucine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051047">
        <property type="entry name" value="AccD/PCCB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011762">
        <property type="entry name" value="COA_CT_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43842">
        <property type="entry name" value="PROPIONYL-COA CARBOXYLASE BETA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43842:SF2">
        <property type="entry name" value="PROPIONYL-COA CARBOXYLASE BETA CHAIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50980">
        <property type="entry name" value="COA_CT_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CoA carboxyltransferase N-terminal" evidence="9">
        <location>
            <begin position="39"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="10">
        <location>
            <begin position="323"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00041138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00042797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDM35947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="582" mass="63159" checksum="668637EAC088B67E" modified="2014-04-16" version="1">MTKDNDSPSTRTGKDQATDRLQQVSSHISPPEQPRKSKPKPKSTETHLPADHSDVLGQLAALRAIAAKPDPTNRGYVRQKQAGKLWVRERIEQLLDPNTFQEIGSVSGTVTWQKTAPMREKPVSFVPSNNIQGAGLLRGRKVLLTADDFSIRSGHADGASTGKTVYVEKLAIALRMPVVKLVDGSSGGGSVTIIQKEGWSYLPHVASFPYVIKQLNMGIPNLGAVVGPAIGLGAARVVSCHFSVMAADIGALFNAGPKVVEGATFEEGLEFQDLGGPMVHCTNGTIDNLAANEAECYEQLRVVLSYLPNSGSDAPPTIPCTDLEEREDVALRSIIPRRQARMYNARSIITSVVDKDSWFEIGALWGRTAIGGLARLGGRPIGVISVNCEVNGGALDAAGSQKLTRLLKLCDVMNLPILQFLDIPGYAIGTVAERTATMRWGVELAKAYFSTTVPVFNVVTRRVFGVAGGIMLGCRDPVMQVAWPSGQWGSLPLDGGIEVGHRHELREAEKVGKKEERYQELEEEYLRLMNPVRTANAFGIEEIIDPKDTRKVCCAWASHVYEVLMKDRLADRACGKLQPSFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W6R3R1</accession>
    <name>W6R3R1_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Alpha/beta hydrolase fold-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PROQFM164_S05g000275</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6R3R1"/>
    <dbReference type="STRING" id="1365484.W6R3R1"/>
    <dbReference type="OMA" id="EVDGPYF"/>
    <dbReference type="OrthoDB" id="425534at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013595">
        <property type="entry name" value="Pept_S33_TAP-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051601">
        <property type="entry name" value="Serine_prot/Carboxylest_S33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43248">
        <property type="entry name" value="2-SUCCINYL-6-HYDROXY-2,4-CYCLOHEXADIENE-1-CARBOXYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43248:SF25">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08386">
        <property type="entry name" value="Abhydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="112"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S33 tripeptidyl aminopeptidase-like C-terminal" evidence="4">
        <location>
            <begin position="408"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDM36442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="515" mass="58004" checksum="78F671EC42BD574A" modified="2014-04-16" version="1">MKKSLLLGDFARKQQLQASRPKYWAIVSVILICSSFALKHWSVEIPTWHQHRTLKYTGEQISWEPCGFIKGNFVECGNVFVPMDQFNQSNSGNKIFTIPLIRMRGTNATQNLILNPGGPGASGFEFLNQNAEQLRAIVGEGLHLVSFDPRGVNSSTPLASCYPDVKSRKDLAHVRSRNVEIDSPEVYAWTQNFVKACHDTMGEHAKYLNTPQTAADMNDILDALGQRDMVYWGFSYGSLLGQTYAGLFPERSKRVIIDGVVNQFKWYDGTFEIESQVDTDKVLDGFFEECTRAGTKKCPLSSLATSVELRDTVLSYMNRLREQPIGVYVNNTAHGVLGYEELCLIQGNATNAFLAYGREDSWDMGHEASEFIRLNDGLSGPKNWPQDRQPLLDYILTSFNQSMFGARHSKIFFMRQQWTMPRTHSYVPRKGVTTAHPLLILSTTWDPVTPLTSARSAKEAFQDSQIVEVKAYGHCSIAVDSSCAANIIRDFLYEGKLPHAYTECEVDSPYFKESD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2020-02-26" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>W6R4H4</accession>
    <name>MPAG_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">O-methyltransferase mpaG</fullName>
            <ecNumber evidence="7">2.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Mycophenolic acid biosynthesis cluster protein G</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">mpaG</name>
        <name type="ORF">PROQFM164_S05g000555</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>FM164</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2016" name="PLoS ONE" volume="11" first="E0147047" last="E0147047">
            <title>Identification and functional analysis of the mycophenolic acid gene cluster of Penicillium roqueforti.</title>
            <authorList>
                <person name="Del-Cid A."/>
                <person name="Gil-Duran C."/>
                <person name="Vaca I."/>
                <person name="Rojas-Aedo J.F."/>
                <person name="Garcia-Rico R.O."/>
                <person name="Levican G."/>
                <person name="Chavez R."/>
            </authorList>
            <dbReference type="PubMed" id="26751579"/>
            <dbReference type="DOI" id="10.1371/journal.pone.0147047"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>CATALYVITY</scope>
        <scope>PATHWAY</scope>
    </reference>
    <comment type="function">
        <text evidence="1 4 7">O-methyltransferase; part of the gene cluster that mediates the biosynthesis of mycophenolic acid (MPA), the first isolated antibiotic natural product in the world obtained from a culture of Penicillium brevicompactum in 1893 (PubMed:26751579). MpaC methylates farnesyl-DHMP-3C (FDHMP-3C) to yield MFDHMP-3C (By similarity). The first step of the pathway is the synthesis of 5-methylorsellinic acid (5MOA) by the cytosolic polyketide synthase mpaC. 5MOA is then converted to the phthalide compound 5,7-dihydroxy-4,6-dimethylphthalide (DHMP) by the endoplasmic reticulum-bound cytochrome P450 monooxygenase mpaDE. MpaDE first catalyzes hydroxylation of 5-MOA to 4,6-dihydroxy-2-(hydroxymethyl)-3-methylbenzoic acid (DHMB). MpaDE then acts as a lactone synthase that catalyzes the ring closure to convert DHMB into DHMP. The next step is the prenylation of DHMP by the Golgi apparatus-associated prenyltransferase mpaA to yield farnesyl-DHMP (FDHMP). The ER-bound oxygenase mpaB then mediates the oxidative cleavage the C19-C20 double bond in FDHMP to yield FDHMP-3C via a mycophenolic aldehyde intermediate. The O-methyltransferase mpaG catalyzes the methylation of FDHMP-3C to yield MFDHMP-3C. After the cytosolic methylation of FDHMP-3C, MFDHMP-3C enters into peroxisomes probably via free diffusion due to its low molecular weight. Upon a peroxisomal CoA ligation reaction, catalyzed by a beta-oxidation component enzyme acyl-CoA ligase ACL891, MFDHMP-3C-CoA would then be restricted to peroxisomes for the following beta-oxidation pathway steps. The peroxisomal beta-oxidation machinery than converts MFDHMP-3C-CoA into MPA_CoA, via a beta-oxidation chain-shortening process. Finally mpaH acts as a peroxisomal acyl-CoA hydrolase with high substrate specificity toward MPA-CoA to release the final product MPA (Probable) (PubMed:26751579).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(4E,8E)-10-(4,6-dihydroxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4,8-dimethyldeca-4,8-dienoate + S-adenosyl-L-methionine = (4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4,8-dimethyldeca-4,8-dienoate + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66696"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:167389"/>
            <dbReference type="ChEBI" id="CHEBI:167390"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:66697"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Secondary metabolite biosynthesis; terpenoid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="4">Results in dramatic reduction in MPA production and leads to the accumulation of DMMPA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-independent O-methyltransferase family. COMT subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="7"/>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6R4H4"/>
    <dbReference type="SMR" id="W6R4H4"/>
    <dbReference type="STRING" id="1365484.W6R4H4"/>
    <dbReference type="OMA" id="TRWEWIE"/>
    <dbReference type="OrthoDB" id="1535081at2759"/>
    <dbReference type="UniPathway" id="UPA00213"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140722">
        <property type="term" value="P:mycophenolic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="COMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712:SF1">
        <property type="entry name" value="HYPOTHETICAL O-METHYLTRANSFERASE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005739">
        <property type="entry name" value="O-mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0489">Methyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000449218" description="O-methyltransferase mpaG">
        <location>
            <begin position="1"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="306"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="335"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="362"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="264"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="A0A0B5L781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="F1DBB3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="26751579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="5">
        <source>
            <dbReference type="PubMed" id="26751579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="6"/>
    <evidence type="ECO:0000305" key="7">
        <source>
            <dbReference type="PubMed" id="26751579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM36722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="398" mass="44077" checksum="00FD1BE57107E05F" modified="2014-04-16" version="1">MLTKSVTSILQGITLAAKEFENNEAGARESLIAHSRALISALEVPSEFIQHTFWSQPALSAIIRLAADVNMFQHLKDAAGKGIDCEALSMKTGVDASLLSRLARHLVAMNVITFQNGAFHGTDLSDSLAAENYQHSIRFCHDVSRPSFNEFPEFFKSNGYKTPTLSGTDGPFQAAHKTELTFLQWLVNTHPYLQYFHSYMSVYRAGKQNWCDTGFYPVSERLLSGFDASVSDVVLVDVGGGRGHDLETFASKFSPLPGRLVLQDREQTIASMPADESRQFEATAHNIFTPQPVKYARAYYMHSVPHGFGDEDAIKIMANLVPALAKGYSRVLLNEIVVSEENPILAATNMDMIMLAHLAVKERTEAEWRYIFTQAGLKVVNIYSYPGVAESLIEAELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W6R4Z7</accession>
    <name>W6R4Z7_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7703 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S05g000730</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6R4Z7"/>
    <dbReference type="OMA" id="RYGGCYF"/>
    <dbReference type="OrthoDB" id="405906at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056120">
        <property type="entry name" value="DUF7703"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37013:SF7">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37013">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_1G05950)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24802">
        <property type="entry name" value="DUF7703"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="55"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="119"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="163"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="202"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7703" evidence="3">
        <location>
            <begin position="26"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="279"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="312"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM36897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="327" mass="36297" checksum="27D7DE1AF592A45D" modified="2014-04-16" version="1">MSLADIAGRNFTSPDRSGDQFAVHTVVACLIGIAWYNALELIVLCFTTFKRYGGCYFWCLLLASFSIIPFGMGYILIIFNVYDNMFPVAMELVAWVGMVTGQSLVLWSRLHLVCHSRTVLRVTLAMIIVDAIILHIPGAVLELGSHSNKSSLFTDGFNIFERIQLVGFSIQEIILSIIYSWEAVRLLNLRPRGHYRGTLVQLLIVNVVMIMMDAAVIGVQYSGLFDIHVTLKAMVYSVKLKLEYAILGKLVHITEGGSGSTPTDLSDFVDLSLHNPRTPRPDRDTIRENPENGSNTRVRVPSKGSSTDPLRRSLSAHSPSSSNPDYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W6R5R1</accession>
    <name>W6R5R1_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CENP-A-nucleosome distal centromere subunit CENP-Q</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S06g000113</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792020">
        <property type="protein sequence ID" value="CDM37152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6R5R1"/>
    <dbReference type="STRING" id="1365484.W6R5R1"/>
    <dbReference type="OMA" id="QMKNEHP"/>
    <dbReference type="OrthoDB" id="2420947at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025212">
        <property type="entry name" value="CAD_CENP-Q"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13094">
        <property type="entry name" value="CENP-Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM37152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="254" mass="28691" checksum="489B70669E6AB14B" modified="2014-04-16" version="1">MPPKRKHTGDDAPQEDDSKGYAYLKPHIRRVPEKTIKSKWAPLPEPVQGKVMDMFHSLERPVIMRNQNERKRIEAQGAVQAVVRNLGKRLPRMPFPPITKDSNFDYESALNEHRSLEAHLATMNDSVDLLKAEIAKEEALLARETKSLQEMDKNAKRAEAERKRQTKNEHPVLRQLDALPRTEDSGSSEFMLLGAKDSQVTLDELETDPEVQGLMKQLHGHLQSMESNIAPFAGLGDAITRSQAALDLYSIPND</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W6R6H7</accession>
    <name>W6R6H7_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Short-chain dehydrogenase/reductase SDR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S06g000384</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792020">
        <property type="protein sequence ID" value="CDM37422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6R6H7"/>
    <dbReference type="STRING" id="1365484.W6R6H7"/>
    <dbReference type="OMA" id="QINWLST"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF31">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM37422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="349" mass="37738" checksum="6C815681C97DA4D8" modified="2014-04-16" version="1">MPFYNSYPGFLYRQFLVCPSKAPSTTSLRGKAGIVTGSNTGLGYQASAQFLGLGLSHLILAVRSISKGEAARNSLLASLPASVKPPVVEVWELDLGSYASTIAFVERLKKSDIQVDFALLNAGVANFNFTINQPTSHESSIQINWLSTALLTLLLLPVLDQQAANNLNRARPVISIVGSETAAWAKFPEAQVSIKQGLPLIQVLDDKANFDMGDRYYTSKLLYQLFFLELFRNRSSAKRSTGAILNLVNPGFCYGSELHRTAEGAFGKVLAGMKRVIGRSVSMGARTLVHSSVLAGDASNGKYLSDNKQAPFAGYGDSDSGRIIQAQVWKETISELAPVVDIDKVLSQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W6R6J1</accession>
    <name>W6R6J1_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type DNA-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PROQFM164_S06g000399</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792020">
        <property type="protein sequence ID" value="CDM37437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6R6J1"/>
    <dbReference type="STRING" id="1365484.W6R6J1"/>
    <dbReference type="OMA" id="MIWQLST"/>
    <dbReference type="OrthoDB" id="4132249at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050797">
        <property type="entry name" value="Carb_Metab_Trans_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668:SF20">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="9"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDM37437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="582" mass="64790" checksum="BF432B9B062678E2" modified="2014-04-16" version="1">MPDPPAKQACDACRRRKVKCIFPKPCEQCRAAGLVCRTSSQRQKKGRQGQTANILNELRANQIELALAQDANISPPSMALGLGDTIPTPQSLQTSGRCQFAKTPGLVSGELVNACSGYFFSRMRGTVPVLQPGSFQKRVDLADTCLHAYCLVTAFCAFVVTQTGFAVEHSSLEFSRVFCTEDYRNSLIEEATEARKHIDPFTDPIRQSIIIAFLLYGCHIGLGNQRHAYYFLRESTTLYTASALESQASSAQVDDDDPSLAGKLFWLLVVSERAHAIRRHRPITLQVTPESPRLEDDPLPTQLEDNVLENASAIGFRCLVNLYRPFDESFLSQWNGTNATCSIESLVRLEELIQSAVPADLDLPDILMADLRVSQQWLRIMIWQLSTTAGFLSTKPSHECMDFRYPLLIAEDLCFATWKLSRQSMETHGIGLIEKIFEVACTLIDVMACLSTARLRSSGFKLGPQDYLKHFFTLIHDLPGGRRRLLPLLLTKIGQTLPSMVDPITVHLKLQPSPLVSSSTNEESSISAIARSGNSIEQPSTELVSESANWMNGNFNYAEMSRIGEKTPEIDEAFLQYSSYFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W6R6R6</accession>
    <name>W6R6R6_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Glycosyltransferase, DXD sugar-binding motif</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PROQFM164_S06g000489</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 32 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792020">
        <property type="protein sequence ID" value="CDM37527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6R6R6"/>
    <dbReference type="STRING" id="1365484.W6R6R6"/>
    <dbReference type="OMA" id="NRHSWSF"/>
    <dbReference type="OrthoDB" id="3647at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000030">
        <property type="term" value="F:mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051999">
        <property type="term" value="P:mannosyl-inositol phosphorylceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.20:FF:000001">
        <property type="entry name" value="MIPC synthase subunit (SurA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051706">
        <property type="entry name" value="Glycosyltransferase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007577">
        <property type="entry name" value="GlycoTrfase_DXD_sugar-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32385">
        <property type="entry name" value="MANNOSYL PHOSPHORYLINOSITOL CERAMIDE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32385:SF20">
        <property type="entry name" value="MANNOSYL PHOSPHORYLINOSITOL CERAMIDE SYNTHASE CSH1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04488">
        <property type="entry name" value="Gly_transf_sug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="270"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="338"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM37527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="358" mass="41667" checksum="54B1E31ECCE49B0C" modified="2014-04-16" version="1">MRRGLVIFLLVNLIILSLLVRSVSTLLALLVEDAAADAIHRAELPSPNSSLIEHRPQIIPKIIHQTYKNETIPEVWVGAQQSCIDLHPDYEYILWTNEKSREFIAAEYPWFLDTFDGYSYPIQRADTIRYFILAHYGGTYIDLDDGCNRRLDPLLAYPAWVRRTAPTGISNDAMGSVPQHPFFLRTIEELQKYDRHWLLPYITVMYSTGPLFLSVIWKEYMRDGPSEAGRVRILMQDEYNKFSWSFFTHHRGNSWHGKDAHLIFWMGEHWVFLTICGFLLAGIVGFCLWWSYGRVMLLGAKYRYRYSKVSGIPPRLSTSPTRRSRLSVPTLLRRVSFKEDEESGGVTETSYELERRDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W6R737</accession>
    <name>W6R737_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S07g000005</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792021">
        <property type="protein sequence ID" value="CDM37657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6R737"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM37657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="49" mass="5716" checksum="EEAEC6468F99162E" modified="2014-04-16" version="1">MDQAMLTRSFFGNLLLSTILKALLLLSLVYIQPHWCFTLYQGSFWLDCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W6PQP5</accession>
    <name>W6PQP5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Probable transposable element</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S01g000024</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PQP5"/>
    <dbReference type="STRING" id="1365484.W6PQP5"/>
    <dbReference type="OMA" id="QCANAIL"/>
    <dbReference type="OrthoDB" id="4324149at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF74">
        <property type="entry name" value="POGO TRANSPOSABLE ELEMENT WITH KRAB DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="2">
        <location>
            <begin position="53"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM26215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="552" mass="62976" checksum="861DA5C72EE5DA0D" modified="2014-04-16" version="1">MDKPYSDVERRILTACSVARTSKKPNFAALAREYEVPVGRLRARFAGRKSRSTRQMTYTRLNEDQIASLVRWIRCLDNLHVPPTAKMVAISANALLRRANSDARPLAKDWVYDFVAQHLPEDLFWVQQKPADQKRILAEDIGVLTAWYDRLEPFIKRIPTKNIYNFDETGFLLGQGRPQNVISANKHRTRTHSFERGQLVTGIECVAADGWVMEPYFVAPGKAHLVRWYDGGKLSEETRIAVSDSGYSNDLLAIDWLHFFAENTSHRLGKSTKEPRLLIMDGHGSHLTYEFLDICDFYNIIPYVCPPHTTHLIQPLDGSPFRALKQAYRTKNNEIAQWGGDARDISVFFTEITAIRATAMTPRTIRKAFATRGIYPYNPKLVIEPLVAAQTPEPDLKIFDGTPPPEQISSIPYTPPKSVWDARRTRNKMVNILDKSPLPADIRDQLLRVAQSQIQLAEDKGLLQDTLENRLPKQRKIARKSQKQIGKFGALSTKDANRHIRDRKKAEEIKEALTELRNPLPYAAMSDASRARLDNFEVEHPPLLPNLEEDYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W6PR40</accession>
    <name>W6PR40_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Tyrosine--tRNA ligase</fullName>
            <ecNumber evidence="8">6.1.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Tyrosyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PROQFM164_S01g000020</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>tRNA(Tyr) + L-tyrosine + ATP = L-tyrosyl-tRNA(Tyr) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10220"/>
            <dbReference type="Rhea" id="RHEA-COMP:9706"/>
            <dbReference type="Rhea" id="RHEA-COMP:9707"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78536"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.1" evidence="8"/>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PR40"/>
    <dbReference type="STRING" id="1365484.W6PR40"/>
    <dbReference type="OrthoDB" id="337870at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004831">
        <property type="term" value="F:tyrosine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006437">
        <property type="term" value="P:tyrosyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00805">
        <property type="entry name" value="TyrRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000227">
        <property type="entry name" value="Tyrosine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.240.10">
        <property type="entry name" value="Tyrosyl-Transfer RNA Synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002307">
        <property type="entry name" value="Tyr-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024088">
        <property type="entry name" value="Tyr-tRNA-ligase_bac-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00234">
        <property type="entry name" value="tyrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11766:SF0">
        <property type="entry name" value="TYROSINE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11766">
        <property type="entry name" value="TYROSYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01040">
        <property type="entry name" value="TRNASYNTHTYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM26211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="438" mass="49705" checksum="C3D382E8EF6A0DF8" modified="2014-04-16" version="1">MRPRSTPLVRATCRNAPLPRTASCGARSFAAASQTNPLRCETRRPALFFQQSQCTPQQKRLITQQWLKRVQDGKDEWARHAEEINEGKRKSFAAHLEERGLIHDVVGERDLLHQVFTEKRVGIYVGIDPTAPSMHVGHMLPFMVLAWGYVWGLPVTFLLGGATSRVGDPTGRLKGREKVHTSIRKANMASMHMQLKKLGTSIEQYGRRHGYQKQAIWRRALVNNNTWWNSMPFIEVLRDLGAFTRLGPMLGRDTVKNRMNQGDGMSFAEFSYPLLQGWDWWNLFQKGTQVQVGGSDQYGNILFGMDAVKSISRNTADEQKRNPLDSELDRPIGFTTPLLTASSGEKFGKSAGNAIWLDKSMTTTFELYQFFVRTPDDTVERYLKLFTFIPLPEIHRAPKLERRSGMRTGGLCGYPSSQILIAFIGHEYRLPDPRSNCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W6PSF3</accession>
    <name>W6PSF3_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S01g000495</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PSF3"/>
    <dbReference type="STRING" id="1365484.W6PSF3"/>
    <dbReference type="OMA" id="VSHPQYG"/>
    <dbReference type="OrthoDB" id="3009558at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM26686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="531" mass="59881" checksum="B7B7AD6C1C046AE1" modified="2014-04-16" version="1">MSAKRPRLASPVRYNRLPIPETDIDTSFPRYQTLSPRLVLRTDSQVWGLPESAEIRAIHTLETTPENEQLVRTHHPALRLRDLVYVSHPQYGPEVWLVNGACEDIEAGGRPLHPYPEDRRNLYPSGILTPRSPWKEDYLFKEGINPRKFLSPEKIDGLRELFPTAVGARVFVSGFLVVLFKSLHDIQAIYEENWIMEAGGLRILYDEYRLEATADTVTSGMEVCDKPESLQGQGCLGLRIRMNDGKEAITTVTHGFVRNPRRSRMTKMFSEWILRAKRALLCLRNPPPQSDTSAIGVVRNSNKNSPIGKEVWLATEKKRIGTISYTFDDPSPVLPFPSGYRHDLSLIMDDELPQLISPPGYPAVSEWASYSTVLVGSDVYVVRMNTVVGRWALLEGTVGPNAIRNATVIGTQYLWDRTAHSQTASLLWKTKEPFSPADGWSGSVLCLGRPTDELSQAVVFQNFEVLCTTFVELEPGRTQDVLVKGGFLLPESIRSSQIVIGNDEHRGRNSDIYPRRRTERAVLDRRVFSAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W6PT24</accession>
    <name>W6PT24_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyltransferase 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S01g000839</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PT24"/>
    <dbReference type="STRING" id="1365484.W6PT24"/>
    <dbReference type="OMA" id="DSHWFRR"/>
    <dbReference type="OrthoDB" id="5405781at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050879">
        <property type="entry name" value="Acyltransferase_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23028">
        <property type="entry name" value="ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23028:SF128">
        <property type="entry name" value="ACYLTRANSFERASE 3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="364"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="421"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="Acyltransferase 3" evidence="2">
        <location>
            <begin position="35"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM27030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="481" mass="55286" checksum="B7209EBD52501CDB" modified="2014-04-16" version="1">MEYIQPTHLYSRILDNIPWKSADPSVKGDPRKSVKWIDGLRGIASFLVILTHLTRGWDYDLFAPRDDVDSPPRILQWPVLRIPWQGRLGVTIFAFLTGYVCALKPLKQSRNGDILGSFTSVGKSAFRRPPRLIFPATIALLISWVMAQFGAFVAANRSDCWWCRYAAVDLAPTFWEEFVRLFKTFLEVWTTGYMAYDDHQWALLPLLQASMLVYVLICATMFCKFRFRMAIYVGMYLYFHQNAAKNTETFQMQAVYGMFLSDLSYENGFKEFVERHSWGRKIVAGLLVCLGLFVCSYPGEHPEWATWSAYMERASHYIFPPEVNVGRRYSALGVDLIIFAIYISPSTKEFLSSRLLLWLGKQSFAVYLVHGTLLRTVLCWMLYGITGQPWDGDIVDEKGNPIYGEDGEPLHPHWIPIRAPWVVAISIPAWIVLVYFCATLWTGYVDPFCARMAQKLEKWMFEEGEQAPPQLPMTSIPMQTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W6PT26</accession>
    <name>W6PT26_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Peptidase A22, presenilin signal peptide</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PROQFM164_S01g001142</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase A22B family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PT26"/>
    <dbReference type="STRING" id="1365484.W6PT26"/>
    <dbReference type="OMA" id="TFWTGTL"/>
    <dbReference type="OrthoDB" id="29661at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098554">
        <property type="term" value="C:cytoplasmic side of endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098553">
        <property type="term" value="C:lumenal side of endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042500">
        <property type="term" value="F:aspartic endopeptidase activity, intramembrane cleaving"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033619">
        <property type="term" value="P:membrane protein proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007369">
        <property type="entry name" value="Peptidase_A22B_SPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006639">
        <property type="entry name" value="Preselin/SPP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12174:SF23">
        <property type="entry name" value="MINOR HISTOCOMPATIBILITY ANTIGEN H13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12174">
        <property type="entry name" value="SIGNAL PEPTIDE PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04258">
        <property type="entry name" value="Peptidase_A22B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00730">
        <property type="entry name" value="PSN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="120"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="190"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="227"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="257"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="289"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="330"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="418"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="51"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="481"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="526"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="485"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="526"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDM27333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="622" mass="69944" checksum="236C535EB7207F31" modified="2014-04-16" version="1">MADVSPVAELLGQAFYHFDRLRPLLPTYGHLLVSALFPIWIGAHASLTRPSSAAKPAKKQSDKDKDENDTDDEEGHGPLQKMEGLEPSDALIFPLTAGLTLGGLYLVIKWLEDPAILNKILSFYFSQMGLFFAFAFLKDVLLMIRSFVFPRYYRQGGRLWKAKQSEHLFMASEDHPAKSHSIRNSPLPGILGYLPLPSMVLGLLWKCRNVSYQRLKVRGHIRGLFDFRCLVGLLDIVSGSLALSAVGYFAFVANPWWLTNFLGFCFCYGTLQFMSPSTFWTGTLIMGSLFFYDIYFVFFTPLMVTVATKLDVPIKLLFPRPPTSRDAPGSVPLAMLGLGDIVIPGMMIGLSLRFDLFLYYQRKGAQMARLERSDQATVKPEYQSAIGAWGERFWAPPVKPLQPELQPPYYDARCFPKIYFKASIAGYVVGMVTTLLAMQYSNHAQPALLYLVPGVLISPWGTAFIRGEIDTMWDFSDAEEVDIEEEKKENEAEDKPSSQEKSLFMRIFSGDYLRASKDENAMRAMKVKEENIDDSKSETKSSKEGGRNAKTKKPKKDRDSADLISFTVSIPGKPKREMLVNSPTTSTEEEDAEVSVSRDANGDNEPPLKRRRRSMMNKSSAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W6PT82</accession>
    <name>W6PT82_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Isochorismatase domain-containing protein 2, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">isoc2</name>
        <name evidence="4" type="ORF">PROQFM164_S01g000899</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the isochorismatase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PT82"/>
    <dbReference type="STRING" id="1365484.W6PT82"/>
    <dbReference type="OMA" id="HVCVFQT"/>
    <dbReference type="OrthoDB" id="269496at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="entry name" value="Isochorismatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050993">
        <property type="entry name" value="Isochorismatase_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14119">
        <property type="entry name" value="HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14119:SF3">
        <property type="entry name" value="ISOCHORISMATASE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="Isochorismatase-like hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase-like" evidence="3">
        <location>
            <begin position="30"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM27090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="221" mass="24111" checksum="1F77B6798D654F92" modified="2014-04-16" version="1">MATLARSSRIRKKPPNPNAVQVNTRPGNPALFICDIQEKFRNGIYEFPKLVLTAEKMLRAASALKIPVFVTTQNRAKLGNTVPELQQHLSDTHVRADVDKTLFSMITPEIEKLLPAPGSAPLDVIIVGIETHICVTQTTLDLLERGHRVYILVDGVSSMNTEERGIALSRLRDAGAVVTSSESVLFEILGDASHEAFRAVSGLVKETKDNTKGALGVFSKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W6PTG5</accession>
    <name>W6PTG5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">F-box domain, cyclin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S01g000865</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PTG5"/>
    <dbReference type="STRING" id="1365484.W6PTG5"/>
    <dbReference type="OMA" id="RNHRIMF"/>
    <dbReference type="OrthoDB" id="550575at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101908">
        <property type="entry name" value="Putative isomerase YbhE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="8"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="528"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="578"/>
            <end position="605"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM27056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="605" mass="66159" checksum="E107173B9F259C14" modified="2014-04-16" version="1">MTAVSSTVDPLSVLPPEIVLQILHFTPISGLASLTATSKAWHQFIDGTHQEAIYGSEAKTVQPLGGSREFSFLADTHSFSKIFEGTKSWKDLCKRQTLLALNWAQPHPVSQESVVQIGNDPIWRFRADFKRRFFISTSHGGGLNVTDMDTGRLLWRLPSVLDAEGDGDGVRPHAHLEYQDGMAVFDSEGDLLEVWQTDLEGAKRGEFRRIATLCHDCHTRGFQLSYWTLCVVSNEGRGFVYDMTQRPPKLTTDLRIEGGGIGHLDQSEDIVIYSMGSKGYFAHSKESGALLGNLKPSQSTEKYHILPPKTASASTSAALAGAARLGLTTQPLTPGAFRKDCLVPIEVAEGPLSPPDDPDHVWHGDDEWGAGMLNGDLFVGFSRAGRVFICPDFRKALRDEASLAANSYILECQSDGSSFDLGGWLSIRNHRVMFEIQDRIYVVALDDNNRVQNLKNPARASYSLLTSSAPQLAVPISYMALADDAIMTTYTTLGWRDSNVPGGIPGGEIPRVFPTKVIRILSLAPNLSKQSSASGDTDEPSAVDSASLGGPGPNLPSSDAWRTQAGLLQLLSVLSNETDLEQSDGEDEWESMDEDEEEDEEEEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W6PU81</accession>
    <name>W6PU81_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">F-box domain, cyclin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S01g001251</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PU81"/>
    <dbReference type="STRING" id="1365484.W6PU81"/>
    <dbReference type="OMA" id="WYQVKRD"/>
    <dbReference type="OrthoDB" id="5554140at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009976">
        <property type="entry name" value="Sec10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048627">
        <property type="entry name" value="Sec10_HB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12100:SF1">
        <property type="entry name" value="RECYCLIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12100">
        <property type="entry name" value="SEC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07393">
        <property type="entry name" value="Sec10_HB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="29"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="489"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="502"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM27440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="888" mass="99549" checksum="56A5D0FD40889C0B" modified="2014-04-16" version="1">MPGAKKGPTAAAQARRDVLASLRMASMEDISRAALPAEIVSSILDHVGPVDLIRAARSCKLIHEMAYDDTRWVHKLKRIGCWDEADARKHAEVVFGTVANMEVVEQQEEAELVGPVPAATDDPSSDLKALSDGFDKIELVNTASQPTLFQDLMDEPALTVLKQVRSIRGEARQEYGKIHAALAPFYEDIARSEPSSENLVFTKYKDPQAQAQILAQLLMFSKSDMTQGWDERVDRLERTVSMFETAALKEFRQGYETDDIDGAMRKYAHILWTLNGGQAAVDLFIHHNHLMTRKSDLGSVASCIDGSTGQLKMEQTQAFFTRLSVAFNDEISIMNRVFPPALDVTSTFMTKVGEDVLSPFLAAIFDELHGVSIKSYLTAISTTFVQCMNLSEALLPIRGSDAKFDEYLDNVVIKVYEPHLDLYLAEELDFFKKACEFTVSEWDRHLSEQAASTESFLMSNVNRQADKRDFLTSFKKVIMMPVNILPGFSSAKSNEESKPDTETSSPNPLQPSKNTNRFSTISSPAPVAVDEAPTTELAAKAAIMKIKMEGIRSLFSIEIALDLVHSAKSSLERAAQFVRLGGEFGLAAKQQCEAIFVTLLRILGYQHVIVGFDKAVSHLSNYRPREQGERDQSGVEPLVTFLELVNVGDLILQMMDVFYEQELIGMRLTDRNDFVDPANKEKKKFEQMLDERVAAGLNKGIDVLMEEVDYILATRQPATDFNPGVSPDPHRQTMDVGVSEVAVAVVDVVSSHTQMLVGSTDKSTLDVFNQEVGLRLFTALCKHLKRQRISVEGSLKLISDMNHYFKYIQTLRNNELLLYFTAFRELVQIYLIDPGHAKELATVIADADRFHGIWRVEEVYEFAERRADWYLVKRDVERAMYGFGCNLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2024-10-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>W6PUU5</accession>
    <name>W6PUU5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S01g001809</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PUU5"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM27998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="78" mass="8833" checksum="34E296A033252A96" modified="2014-04-16" version="1">MCDFELRYLQRAFNSCSVDEPGHGGVHVRPIVTETGAYDDDVTRYWKLLCGPMVVQFVNVSVPKWHSCIFDGLPGCIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W6PVF2</accession>
    <name>W6PVF2_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g002034</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PVF2"/>
    <dbReference type="STRING" id="1365484.W6PVF2"/>
    <dbReference type="OMA" id="ATEVKWI"/>
    <dbReference type="OrthoDB" id="4449395at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004879213" evidence="1">
        <location>
            <begin position="20"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM28223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="399" mass="44892" checksum="A7E5CDF2C0B5D996" modified="2014-04-16" version="1">MVGSLFGWIALLFEPLAFQVPLIEPQPRLKAENGIAVPAEGPWQEIITGHYAVPPVLKIHDRNSVVKWSWQREDVTQPLPPLIHSGLYSGFNDATDMKWMRGGRSIAAVYSALVVVINHTPDQPSTDKKITFALNRANDVLHNAHTIEPLPGDRLAVGTTGQRPWDGILVYNMSSDLPLVDEPPVLQKIEGLRAIHAMIWDEQGQMLWATGTDAAADGSDPVPAYGVIQGYPFDAETGLLSIDEAYRFRFPEYWDIDVEWGHGYSWWAGPHDLVPVPNERVFLVSNDIGLHAFDIDKMEFTAAYDEVVEKYMPGFEVTTNDRHGINRQGEYVELPQSDLKGFSLAPDGSFIYTQSLWRLYRGNYTSLVVDGVRTQIMKGNEIYRSRWFGDIDGWPKPKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W6PVY1</accession>
    <name>W6PVY1_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">U3 small nucleolar ribonucleoprotein protein MPP10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PROQFM164_S01g001881</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in nucleolar processing of pre-18S ribosomal RNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
            <location evidence="1 7">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the MPP10 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PVY1"/>
    <dbReference type="STRING" id="1365484.W6PVY1"/>
    <dbReference type="OMA" id="HFAEDFG"/>
    <dbReference type="OrthoDB" id="445326at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034457">
        <property type="term" value="C:Mpp10 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005732">
        <property type="term" value="C:sno(s)RNA-containing ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012173">
        <property type="entry name" value="Mpp10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17039">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN MPP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17039:SF0">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN MPP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04006">
        <property type="entry name" value="Mpp10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017300">
        <property type="entry name" value="snoRNP_Mpp10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 7" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3 7" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="131"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="231"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="626"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="134"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="159"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="231"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="248"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="283"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="305"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="365"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="380"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="404"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="630"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="641"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="651"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="700"/>
            <end position="711"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR017300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM28070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="711" mass="78523" checksum="7C033A2557C452F6" modified="2014-04-16" version="1">MAKGQPKSKSVSANTAKIPEQMALSSALSSPWGFLRPTNDLHTAVVDSAKHILDSLAGSVVDAQTTRRQLNKKRKRSDLESDSVTQLQLKNLYVEGFTSNQIWEQATRILESTGDEIERDITLITQHSGYMESADSEQLEDISDPEGAQSDSDSHESMLEDLSEGSGAEDDLDEESGEEQEIDMGSDDDMEDMDDMDDDNSSVGSAEGEPEVFVEDRFGLNDGFFSIDDFNKQSEALERQDAAGGPEQTEDSDEEDLDWHSNPLMAGNSATISKSKDSRPTEKEDESMDDSEEEGPTFGNADLNGDSDSDDEDVADMDDGEAAAWVNTSDIKYADFFAPPPRKASNKKHRALPKTQPDAPEVDESDVKRAIDDVRRDLFDDADAGSDEEEDDIDGSADPSAPRSTHEKQRARIADEIRRLEAANVAKKEWMYTGEARAVERPINSLIEEDLDFERIGKPVPVNTNETTEDIEELIKRRILAMEFDEVVRRRPGAEGQQAGRKPRFELDDTKPQQGLAEMYETDHLRANDPNFVDTKDRKLMREHAEITSLWNEVSAQLDTLCNWHYKPKVAQASINVVTDAPTIMMEEARPTAGSAAGGPVGLAPQEIYTPGDNGRVKGEVVLKTGAPISKEEMTREQKAKNRRQNKQTQKKADAAKPTQEKPGKAAEKQQMISDLKKGGVKVIGKDGRMTNIEGGSVHEGAKNRGDNLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W6PW72</accession>
    <name>W6PW72_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g002299</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PW72"/>
    <dbReference type="STRING" id="1365484.W6PW72"/>
    <dbReference type="OMA" id="IARTRWI"/>
    <dbReference type="OrthoDB" id="545169at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046366">
        <property type="entry name" value="MPAB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36124">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36124:SF6">
        <property type="entry name" value="ER-BOUND OXYGENASE MPAB_MPAB'_RUBBER OXYGENASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM28488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="419" mass="48340" checksum="DF53A1461DB6DF95" modified="2014-04-16" version="1">MNYTDALASLQAGGMTTQLLPYAVGLLIAWPVVTTSLRFQRLRKLHKQYAYPTRESMSKMTDEEAFQIQKQVAQLEFPFIFIKSLQFALFRTYGIPSISRLLAKTTQFSNPDTSLKRYTDTSLLVQEWVGNNPTSMRACLGLARTRYLHSGYRASGKILDDDMLFTLALFALQPIRFIDRYEWRKLSDLERCAIGTFWKSAGDALDISYEKLPSGKVGFQDGIQWLEELTAWADEYEVRCMVPDIKNRETADQTTAVLLYMLPKVFHPAGLQAVSFMMDDRLRKAMFYEPPSAFCTALLSTIFTARRLFLRYLSLPRPYFMRFASSTEEPDENDRFFLTEWEAAPYYVKPTFWNRWGPMALLTRAIGRAVPGDEGDKYYPTGYSVADIGPKYFEGKGRKQLEETLVEFKEYRTGKCPFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W6PWA3</accession>
    <name>W6PWA3_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">chitin synthase</fullName>
            <ecNumber evidence="2">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">chsD</name>
        <name evidence="12" type="ORF">PROQFM164_S01g002334</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the chitin synthase family. Class VI subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="2"/>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PWA3"/>
    <dbReference type="STRING" id="1365484.W6PWA3"/>
    <dbReference type="OMA" id="NCIHVFL"/>
    <dbReference type="OrthoDB" id="5321960at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000077">
        <property type="entry name" value="Probable chitin synthase D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF46">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03142">
        <property type="entry name" value="Chitin_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="20"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="60"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="454"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="479"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="507"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="541"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="669"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="708"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="547"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="677"/>
            <end position="689"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00061704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDM28523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="748" mass="84808" checksum="6F5DDCDF5CDDFF08" modified="2014-04-16" version="1">MYSSLLLGSRCHPDHPQQIVYLSIVGPLMLAALFEWFLWLSAFIYCLIKVWMKADHWTIRVLAVVMIFFFTVIRLAFLPVMLVTLPLPPQITVDLPHKIVHGFQMFAFWAFSVLLIGPWLFCVYGLTTNSLGRKKRIKRVLDDRTAPKTVVVMPVYKEDPSVLIKAINSVVDCDYPANCIHVFLSYDGGKVDEPYLRVLDHLGIPITLESYPQSIDCIYKGARITVSRFKHGGKRHCQKHTFKLIDKVYAEYLKTHDNLFVLFIDSDCILDRVCLQNFMYDMELKPGSNHDMLAMTGIITSTTEKNSLLTILQDMEYVHGQLFERSVESGCGAVTCLPGALTILRFSAFRKMAKYYFSDKAEQCDDLFDYGKCHLGEDRWLTHLFMIGATERYQIQLCMSAFCKTEAVQTFSTLLKQRRRWFLGFITNEVCMLTDARLWKRYPLLCLVRFMQNTVRTTALLFFIMIIALLTTSKKVEDLPVGFMGVSLGLNYLLMLYFGLRLGRYKAWLYPLMFIVNPFLNWIYMVYGIFTAGQRTWGGPRADAATADDHTTPGEAVEQAKEQGDEFNVDVDTFRTSLVRQRSVPIRPSENVEGRFAPAKQLLDRFDVNTGPALARMVGAMGTSENSQYQLPSLFRHSTDSVLSASSDCGSSSVATPQNVENLLMSEEDQKKPYHSRQGQASTSSVSLDSQNLENRLNDALPALVSASEHDNLGLTHPPGAYQPGRFENMPPAYTDPEPTVPNKLAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W6PWJ5</accession>
    <name>W6PWJ5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Adenosine deaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PROQFM164_S01g002444</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>N(6)-methyl-AMP + H2O + H(+) = IMP + methylamine</text>
            <dbReference type="Rhea" id="RHEA:16001"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:59338"/>
            <dbReference type="ChEBI" id="CHEBI:144842"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:16002"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PWJ5"/>
    <dbReference type="STRING" id="1365484.W6PWJ5"/>
    <dbReference type="OMA" id="RPQFKPY"/>
    <dbReference type="OrthoDB" id="272271at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004000">
        <property type="term" value="F:adenosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006154">
        <property type="term" value="P:adenosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046103">
        <property type="term" value="P:inosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000033">
        <property type="entry name" value="Adenosine deaminase-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001365">
        <property type="entry name" value="A_deaminase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006330">
        <property type="entry name" value="Ado/ade_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11409">
        <property type="entry name" value="ADENOSINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11409:SF42">
        <property type="entry name" value="ADENOSINE DEAMINASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00962">
        <property type="entry name" value="A_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Adenosine deaminase" evidence="9">
        <location>
            <begin position="37"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDM28633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="372" mass="41391" checksum="6742D78903D2AE90" modified="2014-04-16" version="1">MWGPYSIASEIARWWCSFDQAMDDSKPVDQIFTKALPKIELHAHLSGSISRQCLHEIWKRKKEHNPNLNVEDPLVLMPPGKVDYTLETFFSTFSKLTYQLCNDLESLVYATNSVLEDFLGDGVVYLELRTIPRASPGITREQYISSVLATIETFQSKTQRMSVFLILAIDRGSMTAAEADEIVNLAIENKSRGVVGVDICGNPTKGDVSIYKESISNAKANGLGITIHFAETAASTSASELSTLLSFQPDRLGHVIHVPDEVKKEIARRRLCLELCISCNVHAKMINGGFLDHHFGHWRHEDCPIALCTDDVGFFCSPVSNEYLLAAQHFGLSRADLLEICIKSANAIFAGEYHKGRIQSMLEGFATRFDSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W6PWK4</accession>
    <name>W6PWK4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g000133</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PWK4"/>
    <dbReference type="STRING" id="1365484.W6PWK4"/>
    <dbReference type="OMA" id="VEPPRYF"/>
    <dbReference type="OrthoDB" id="3903267at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM26324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="418" mass="46944" checksum="08BA8497A0ACCF4C" modified="2014-04-16" version="1">MPIKKKAGTRKRDNEADLAELERLRKQVAEQSKALEAEEARREEESQAKRQISSRRQRTLVRWDVDTDIRLLLAIQYACNKLSVKIPWKEVAEVMGEKFTEGAIVQHLSKLRAKREEQDKPNPPPLKRAASCYNKNDANKKEALSPPKDEPPSTRSGKRRRRSPSVEESDDDVYPIKKKQPTKNKKKDKVSAAPKLRGEREQSESGDSRKLLCVGAEWLRDFAGDDCEIDDESASSEENENEDSTESSHVTAQAAKKSKIVTLKLGRERLASVDRYLGGSATFREPMASTNPLRAITNMPPRQPSYRTYMHSVGPFSPDPTTLFGNNISYPSSGPSPFDIPISDADLAGACAFDDVDLTAPYSQFDIPSELQFDPMCSYLNTSGFDNQFIPDDELFASVPDVEPPRYYGYGGEEVQEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>W6PY69</accession>
    <name>W6PY69_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 20">Serine/threonine-protein kinase Tel1</fullName>
            <ecNumber evidence="5 20">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="primary">tel1</name>
        <name evidence="25" type="ORF">PROQFM164_S01g002741</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17 20">Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Associates with DNA double-strand breaks.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 20">Chromosome</location>
            <location evidence="2 20">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 20">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 20">Belongs to the PI3/PI4-kinase family. ATM subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="5 20"/>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1365484.W6PY69"/>
    <dbReference type="OMA" id="HACSVIR"/>
    <dbReference type="OrthoDB" id="381190at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05171">
        <property type="entry name" value="PIKKc_ATM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1070.11:FF:000025">
        <property type="entry name" value="Serine/threonine-protein kinase Tel1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1010.10:FF:000019">
        <property type="entry name" value="Serine/threonine-protein kinase Tel1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038980">
        <property type="entry name" value="ATM_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003152">
        <property type="entry name" value="FATC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014009">
        <property type="entry name" value="PIK_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044107">
        <property type="entry name" value="PIKKc_ATM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021668">
        <property type="entry name" value="TAN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37079">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE ATM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37079:SF4">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE ATM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02260">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11640">
        <property type="entry name" value="TAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01343">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01342">
        <property type="entry name" value="TAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51189">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51190">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00915">
        <property type="entry name" value="PI3_4_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 20" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14 20" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="7 20" id="KW-0158">Chromosome</keyword>
    <keyword evidence="11 20" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12 20 25" id="KW-0418">Kinase</keyword>
    <keyword evidence="10 20" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16 20" id="KW-0539">Nucleus</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 20" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="15 20" id="KW-0779">Telomere</keyword>
    <keyword evidence="9 20" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FAT" evidence="23">
        <location>
            <begin position="1836"/>
            <end position="2434"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="22">
        <location>
            <begin position="2538"/>
            <end position="2849"/>
        </location>
    </feature>
    <feature type="domain" description="FATC" evidence="24">
        <location>
            <begin position="2866"/>
            <end position="2898"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="2825"/>
            <end position="2853"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="2828"/>
            <end position="2839"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00014619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00025079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU365027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS51190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="CDM28930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="2898" mass="325687" checksum="F8091067BD278183" modified="2014-04-16" version="1">MGEIFLDKTISLLSSDKQKARSDGLADLKHILQQNKKSSKLQTLNDKACHKIFESLFRFVAAERSIYNRAQKPTKTPSASRLSTCASVLRMAVGLFLKNLRIRTVRAIVDHITETLPVPGEGLWEPLSLDYTKCLASLLRYRPHAEHLDEEDWKALMSFCLASISPRENEESQLSIRSGYRFVPEDQDASDSRSTPSRMTVAPVSVSRERHSGNRNVIEEVVICIQLLTTSTNPPLHTTAQSILHGLSEFVESSVAGNTHQLAFNSINAVVTKVMFDQSELVRLVLSGLVPVIRRLWATKVQILKEELLATLMLSMIVFVDTARKDPSESLAHDIEGLASTLHSEYVRRAEKEIMQIDETTLYHNEACRTRPVYGPCFGTARSEHDWTVLWLIAELLKLSECIHTRVKSGSAREASSKRQRFSSEIQDVFRDSVSATGTKRICALQLIPFLESEVDIETKEPFFKQLVLNISGGNGAVSSWTMVALTSIANGATAKSPRIRVHWPRVVEFTTRAFSSPVTSRAACNLVSMILQSDLLDYSVAMETTRSLLTSVNGPSAISDTSLRLWASIARMRTQLDPRSAQQASIQICSWLREVWAGSVTDRIQTARVAAYARPLDLLDLFLSCTNRSFAIPRYQVTGPTGHIGRTWLFFHENRKLLGYIFDTNFAPANPWSLQETWSLEQFSRQDPDDIAILDLFRVRSDSFLQTWHAMNEEKSHITPDNFQILASFCVVVSLFMACLPPSLQSQPRSQDLHQNCRSLWNAICDFLAAHTHESAFMQSCLDLLSPLLDPLTSSDTPAAIQTSLKELVTPLAKTLEYFRQNSKSPSAAEDFMDVDDRFMAEPPIAIDDTILTLNRNSLSIFLDPVTYQRCLTIQLSVFLRTQADSDSSSVVEYLAGLDEADILAAQAILPEIFKLCSESEPSKLLCILENLGENCLQSYEMERCEASHCVCIRMMTSFVGSWTKGLDDTLKESAMDLYNWFMEVLLARKRATPKVYIALAELIQGVIGTCPSYGNEQSLPSPRTSLFTILREGDVQVKFSVAKFIPALFERFLLKDHDAIFDDVLESLPRDPGWIEGIAVRLFVLSRLASRWHTLLRRSIYHLFETPAQVPMSLWYAERCMVSVSQTLGLQDAKQLFRLFSSQILYTWTETQSIMSMPFSIFRYDSLQDMLMDVKDEIVGQMMMRAKEQETIELAKYLQIPHLELLVTSFYKAEAYSIARDISTPPGQGSQPKGVEIRLRKLLGADQFMTQIESQFPLIIATFFNSLDYYDQIERAFSKRENFGYALDIQTQIINKSASQNALPANQQPSFRTRYLLDEIEFLCRRTGFEFESIWTPSLASFVCRSLLESIHPALGSLHACSVIRKIRILICVAGPVILQDYPLEMTLSSLRPFLSDIHCSEDALGVFWYLLEAGKGYLLSAPDFSAGIAVSTMVTLRGIFSSLPENTTQESQYRTVQSNAKRFHQWLVEFIKEVRSDHLFHEVPKISFDRLVSQAEKFSTCEDSLVGQVGKDLVFAILKDLDSKGAALLSKPLADLILSLLCPQFEQASDTGNWVSNEGVDPASHVVSLWHTLQNSNGGPQYRLWAAQVIGRSFAATGKIDQLLLREQDLSLFEWNESYPLPKDIFCHSKARILMVLCEMLDVQKHFEAGLIERTLRLIVSKVDDYPDYEGCSRVIPISLLGALVWDPYTCPTILLSNSEQERCENAATSVSGLSVADWARNVSLFLSNAAPEDPVIGSLREILNVTPGLAAQLLPYVVHDVLQSEKDDKDKNGKVREDISATFRRVLCEIGEETLPHAQLVIDCILYLRNQPVPDESTIVQRDKWLDIDFREASLAAHRCGLHKTSLLFLEIQTSQVVSTSRRSSVVRYEPPPAFLHDVFKNIDDPDLFYGIQQSSSLSSVMERLEYESSGFKNLLFQSAKYDSEIQMSDNAESYGVLKALNATNLQGIANTMLSASGSANDAPVAFDSMLQAATNLQKWDIPVSPSDSSPSATVFRTFQSLNTSGSLLEVNGSIESGLLTTLGSLLKTSGSAIQLRSSMRALGIITEISDTLHSAFSENVEEEWQNIMARSNWLKTESYHEVGEILSWHEALFSSVRKNDILKSRANLSLGNSRLLEAKVIRQSLEITRTHGISQASLKSAMSLSKLAEPCAALGMNIDGAAKFDLANVLWDQGEMTASIRMLQQLKGQNDLHKQSIPLSRAELLVTLGHHVAEARLEKPDSILQEYLYPAVKELKGNSDGEEAGRVYHGFATFCDQQLLNPDGFEDFKRVEQLRDRKEKEVLGLEDMMKNATGKEREYLKNYRAKAKQWFDLDDREYQRLLQSREAFLQQCLENYLLSLRESDTYNNDALRFCALWLDESDNETANSAVSRYLDGVPSRKFAPLMNQLSSRLLDVSDDFQALLTQLVYRICVEHPFHGMYQIFASSKSKGGKDQSSHSRFRAANQLVDRLKNDSHIGQTWIAVHNVNISYVRFAIDKLDGKYKSGAKVPLGSLTTGQRLGQDAVTYKLPPPTMKISLRADCDYSHVPTITRFYSEFTIASGVSAPKILSASASDGKCYKQLFKGGNDDLRQDAIMEQVFEQVSSLLKDHQPTRQRSLGIRTYKVLPLTPSAGIIEFVPNTIPLHDYLMPAHQKYFPKDMKPNSCRKHIADVQTKSFEQRIRTYRQVTDHFHPVLKYFFMEKFNNPDDWFSKRLAYTRSTAAISILGHVLGLGDRHGHNILLDEKTGEVVHIDLGVAFEQGRVLPVPEVVPFRLTRDVVDGFGITKTEGVFRRCCEFTLEALRQESYSIMTILDVLRYDPLYSWTVSPFRVKKMQMQDKQASDGPAALPGAADDLVSKSGNENEPSEADRALTVVAKKLSKTLSVTATVNELVQQASDEKNLAVLYCGWASYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W6PY85</accession>
    <name>W6PY85_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Galactose-binding domain-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S01g002771</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PY85"/>
    <dbReference type="STRING" id="1365484.W6PY85"/>
    <dbReference type="OrthoDB" id="1657402at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004565">
        <property type="term" value="F:beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025300">
        <property type="entry name" value="BetaGal_jelly_roll_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13364">
        <property type="entry name" value="BetaGal_ABD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-galactosidase jelly roll" evidence="3">
        <location>
            <begin position="17"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM28960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="57" mass="6413" checksum="A5419FEED9CFF200" modified="2014-04-16" version="1">MSVVFNNSIQDITKQNTRGNNYRCQLFVNGYQFGKYINHVGPQTAFPIPGGIINHEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W6PYT6</accession>
    <name>W6PYT6_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 10 12">Alpha-glucuronidase</fullName>
            <ecNumber evidence="2 10 12">3.2.1.139</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12 17" type="primary">aguA</name>
        <name evidence="17" type="ORF">PROQFM164_S01g003245</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 12">Alpha-glucuronidase involved in the hydrolysis of xylan, a major structural heterogeneous polysaccharide found in plant biomass representing the second most abundant polysaccharide in the biosphere, after cellulose. Releases 4-O-methylglucuronic acid from xylan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10 12">
            <text>an alpha-D-glucuronoside + H2O = D-glucuronate + an alcohol</text>
            <dbReference type="Rhea" id="RHEA:20005"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:58720"/>
            <dbReference type="ChEBI" id="CHEBI:58899"/>
            <dbReference type="EC" id="3.2.1.139"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10 12">Belongs to the glycosyl hydrolase 67 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.139" evidence="2 10 12"/>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PYT6"/>
    <dbReference type="STRING" id="1365484.W6PYT6"/>
    <dbReference type="OMA" id="IWRAFVY"/>
    <dbReference type="OrthoDB" id="6501611at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046559">
        <property type="term" value="F:alpha-glucuronidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02795">
        <property type="entry name" value="CBM6-CBM35-CBM36_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1330.10:FF:000001">
        <property type="entry name" value="Xylan alpha-1,2-glucuronidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1330.10">
        <property type="entry name" value="Alpha-glucuronidase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="entry name" value="Chitobiase/beta-hexosaminidase domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037054">
        <property type="entry name" value="A-glucoronidase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011395">
        <property type="entry name" value="Glyco_hydro_67_aGlcAse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005154">
        <property type="entry name" value="Glyco_hydro_67_aGlcAse_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011099">
        <property type="entry name" value="Glyco_hydro_67_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011100">
        <property type="entry name" value="Glyco_hydro_67_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39207">
        <property type="entry name" value="ALPHA-GLUCURONIDASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39207:SF1">
        <property type="entry name" value="ALPHA-GLUCURONIDASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07477">
        <property type="entry name" value="Glyco_hydro_67C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07488">
        <property type="entry name" value="Glyco_hydro_67M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03648">
        <property type="entry name" value="Glyco_hydro_67N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029900">
        <property type="entry name" value="Alpha-glucuronds"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55545">
        <property type="entry name" value="beta-N-acetylhexosaminidase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6 10 12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 10 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="3 10 12" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013266213" description="Alpha-glucuronidase" evidence="13">
        <location>
            <begin position="16"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha glucuronidase N-terminal" evidence="14">
        <location>
            <begin position="21"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 67 catalytic" evidence="16">
        <location>
            <begin position="142"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 67 C-terminal" evidence="15">
        <location>
            <begin position="463"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="295"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="373"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR029900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR029900-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF03648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF07477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF07488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CDM29433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="833" mass="92718" checksum="0BA4FDAC9DA02189" modified="2014-04-16" version="1">MRTLLFFVSLGFAAAENGLNGWLRYASLPCSGQCHYNLPSSISILNATETSPVYVAGTELQNGLKGIYGKSVQVTHNCNISSVVVGTVDQYRKSCGAVNSVPELEEDGFWLDTKGGNVQILGQNERGALYGTFEYLSMLAQGNFSKVAYATNPSAPIRWVNQWGNMDGRIERGYGGPSIFFKDGQIVDDLTRVAEYARLLASIRINAVVINNVNADATLLNPTNLDGVARIADVFRPYGIQVGLSLNFASPQTYGGLSTFDPLDTSVIAWWSNITTQIYDLVPDMAGYLVKADSEGQPGPQTYNRTLADAANLFAKEVQPYGGIVMYRAFVYNQLNESVWTDDRAKAAVEFFKDLDGEFDDNVVIQIKYGPIDFQIREPASALFANLFNTSMAIELQVTQEYLGQQSHLVYIAPLWKTILDTDLRVDHQPSLVRDIVAGKRFNRRLGGSAAVVNVGTNTTWLGSHLSMSNLYAYGRLAWNPADDAQDILQDWIRLTFGLDRKVLGTITRMSMESWPAYEQYSGNLGIQTLTDILYTHYGPSPASQDNNGWGQWTRADQTSIGMDRTVANGTGFSGQYPDEIAAMYENIETTPDDLLLWFHHVKYTHRLHSGKTVIQHFYDEHYRGAETAQTFLTQWKSLHGKIDTERYNHVRHFLDYQSGHSIVWRDAINDFYYNLSGIPDESKRAGHHPWRIEAEDMELDGYEAYTVSPFETASGSVAIVTTSNNTAGTASTKIKFPSGTYDLAVNYYDVYGGQSRWKIYLNDHEIGQWVGNSEDVLSHTPSIYLDGHSAIRIKFRGVKIHKGNTLKIVGMPNGTEFAPLDYVALLPAGIVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>W6PYU9</accession>
    <name>W6PYU9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dbl homology (DH) domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S01g002717</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1365484.W6PYU9"/>
    <dbReference type="OMA" id="HSLHENA"/>
    <dbReference type="OrthoDB" id="10256089at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031991">
        <property type="term" value="P:regulation of actomyosin contractile ring contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032955">
        <property type="term" value="P:regulation of division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07589">
        <property type="entry name" value="BAR_DNMBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.900.10:FF:000053">
        <property type="entry name" value="Rho guanyl nucleotide exchange factor, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051492">
        <property type="entry name" value="Dynamin-Rho_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001331">
        <property type="entry name" value="GDS_CDC24_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22834">
        <property type="entry name" value="NUCLEAR FUSION PROTEIN FUS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22834:SF20">
        <property type="entry name" value="SH3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00741">
        <property type="entry name" value="DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="2">
        <location>
            <begin position="1156"/>
            <end position="1377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="305"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="364"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="574"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="670"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="748"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="924"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1004"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1054"/>
            <end position="1155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1658"/>
            <end position="1718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="364"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="419"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="509"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="576"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="602"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="707"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="756"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="782"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="812"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="825"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="848"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="936"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1025"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1060"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1077"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1104"/>
            <end position="1138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1139"/>
            <end position="1152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1662"/>
            <end position="1718"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM28906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="1889" mass="207886" checksum="C52CFBBE6120D30F" modified="2014-04-16" version="1">MSGGDEQGFDVRYRHPPPFGRQLSAPAFGQSANGHTTTSLGDSPTVSFSPQAQPSTTYAPLSSGFIRPHNSSTSANHLSSGDQLQDCRGRESPDPADYYRQRGSLPGTSSNVREGFGDVRMGMAAADYPSVDDKVSPLPTTMLESSRTRRQPYRSTSDSPTLGAPSVNIPPLHVNPRSRQPSFKDLVNKFNKTTDQVLPLPSVSRPTSRAPSPSGSVDGERNRVLPRRRQYRDSLPESITSNSRAPADSNPSSPEIDRIGPALDTNSAIPPPLFQRITESHTRRPLFGELSPINTQVNNGAISRLQQRRGSDGSIPSPNPAFRERLDQYPAKSPLTPTAWYLGHTTSLEAVQAGINSTGKHRRVLSDLDRTREPLADPWNPEMAVPAPLRQTKPGHGSPPGSPNSKSRIPVCSHRFVTSGSESLSPSSNPTFSSRSAAITSPPRGGSRLPIPSPKQSSPRIPADDPASFATNPRGRRDLTIGRTRNQLSESSRRLEAYIAEPPPKKSPPLRSSRPRQPVSHGAAVSPRSKIGDRVLNLQKHATYNNSRSRPERKLPELVKVDFDARRRHIQQALYRHSDVQENQNDRGPNKSTAGKLRRHASVREQETNEDLKQSMDEPTITPNPPVIHAPSSDEMATMVKDSTGSVEYDENGVQAVPRLHLNTALPASDTAAPHTTMDSPTLGLPQGVDSTTSGEGQPTVDDPTDSGATSDSGDTHVTTFDPEPQSGLLQRNPSVSQTLLDHIMQIRGSNRSDDSCDEPDCSLSENDDRESIQIMLGDTPYYNSSSSNDTQEPERASMHQAQNETDLHNRWSMSSWSSGQHQDSTCDEHCDESGDDSLLRGRETEPPTETCSAVSTRPASMVDDESPASIQDHGVMGPSTLQGSEQFRSNAFSDPPSLARLGRWDSKRATQLYLEELTRGRSHHLGPAVYPSSEPRSHPADTRADGRPDSLTEDPVVVPGFKDFHDSETLSHTASLVGRDDWEHASPSIMDWMQIAAEDDAVTPDTETDGMRTEGVLTPRLVPSANQDAGASNKNNGLGVSVDAQASNDQTLPHAFTSGFLSPSTMHSTDNEPLGGQNSLNSSSHIGLSRSTQAAPRAAGHSPGSSHDSSFRTLESIQSPEAADSSATSLVPSTEQTIRVEPKDSPSPEQRRLKKRRHIIKELVDTEHTFGHDMIIIEDIYKRTSLTVLDPEDVKVLFGNSDQVAAFSDKFLSDLKQAAQSIYVIPKALRWSSKRKRNNQAAESIAPEGAEAAGMSELEKDRATFVGQIFVAHMTQMEKVYTDYLKNHDAANKKLQVVQRIPKVGFWLSECQKGAMDLTTAWDLDSLLVKPVQRILKYPLILRDLLESTPKDHPDHAAISNALEEVTNVSHRINELKKRVDLVGQAVGRKRNHSDVRTGLSKAFGRRTEKFRQQVGLSDLFEDKTYDLLAQKLSDGYFQLQVVMRDAESYSRDVQLYVNQFNEYADSIEEIIGMSPSPYPQLESKWHQFKMTVQELVTTALPEHLAVVRKTVIDPMVELLGLYNAPQRVMRKRDKRLPEYARYKAIKDRGDKPDKKTVEQGEQFLALNDTLKDELPKLYALTSKLMAACLKNFIEIQTVWYSVLQKKIGAHVELFPNDLDRLISDFNSDHTLMEARVGELSCCNGAMMAHSLNLVPLSPGDQHNSMSPRRPSTVNSSKTRPGSMTDDSPNVSRDFSIGSQSYQSPQMESHSSRSSRYRANSILSSRVIPDTSNQLLQQVTSAPALKRTSDIEPFPRLPRLSLDTPFLEDVINSSSHSSYLPASPTDRYSGFFSSAMPMSDVPGDTAVNGHPERSAPPIGPAALFCAASVYDFDIDTRTEGGYPYLTYASGDIFDVIGEKGELWLARNQDDATRTVGWIWNKHFARLST</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W6PZA0</accession>
    <name>W6PZA0_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">UDP-glucose 4-epimerase</fullName>
            <ecNumber evidence="11">5.1.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PROQFM164_S01g002867</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Mutarotase converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>UDP-alpha-D-glucose = UDP-alpha-D-galactose</text>
            <dbReference type="Rhea" id="RHEA:22168"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:66914"/>
            <dbReference type="EC" id="5.1.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 11">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 11">Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Carbohydrate metabolism; hexose metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the NAD(P)-dependent epimerase/dehydratase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">In the C-terminal section; belongs to the aldose epimerase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">In the N-terminal section; belongs to the NAD(P)-dependent epimerase/dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.2" evidence="11"/>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PZA0"/>
    <dbReference type="STRING" id="1365484.W6PZA0"/>
    <dbReference type="OMA" id="GEHLICN"/>
    <dbReference type="OrthoDB" id="9402762at2759"/>
    <dbReference type="UniPathway" id="UPA00214"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003978">
        <property type="term" value="F:UDP-glucose 4-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006012">
        <property type="term" value="P:galactose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05247">
        <property type="entry name" value="UDP_G4E_1_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005886">
        <property type="entry name" value="UDP_G4E"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01179">
        <property type="entry name" value="galE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43725">
        <property type="entry name" value="UDP-GLUCOSE 4-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43725:SF47">
        <property type="entry name" value="UDP-GLUCOSE 4-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0299">Galactose metabolism</keyword>
    <keyword evidence="7 11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5 11" id="KW-0520">NAD</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="12">
        <location>
            <begin position="6"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU366046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDM29056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="371" mass="40489" checksum="8EEB294AC761A547" modified="2014-04-16" version="1">MSAGSVLVAGGTGYIGSFTTLALLEAGYKVVVADNLYNSSVEALHRIELICGKKAEFIKLDVTVENSFDQVFEAHPDIDSVIHFAALKAVGESGEKPLDYWLVNVYGTINLLRSMVKHNVTNIVFSSSATVYGDATRFPNMIPIPEDCPLGPTNPYGNTKFAVETAITDAINAQRNNAIKAGNEAEAKKWNGALLRYFNPAGAHPSGIMGEDPQGVPYNLLPLLAQVATGKREKLMVFGDDYASHDGTAIRDYIHILDLADGHLKALKYLRANNPGVRAWNLGTGKGSTVYEMIRAFSTAVGKDQPYEVAPRRAGDVLNLTANPTRAHTELGWKAERTLEQACEDLWLWTKNNPEGYRQEPPAELLAQLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W6PZD3</accession>
    <name>W6PZD3_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g001098</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PZD3"/>
    <dbReference type="STRING" id="1365484.W6PZD3"/>
    <dbReference type="OrthoDB" id="76567at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM27289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="336" mass="37128" checksum="A6E536FEDA324B1B" modified="2014-04-16" version="1">MDRPQKTEGTMGEANLSIGSNLDSTSASRGSETTTTTPPSQSSYQPFLGESNDLVVPPNARIIRPRSLNDIYDAIEDLKAELDTHTVETHTPRPSQFIWAYQIPQGLFTQIETDLELFPGVRTTIAHNDFAVLLKIMPGRQRERITGNFRVIVMGHLNAMGLSLQNGDFTDQGAEITRGFLQSKEPDWAFGPYDARINSAADEYPATEYPSLILETGFSESLGQLQLDAHWWYRNTTQETKIVVLIDVASDNPYRVNFEVWTEVPNQSHAPVTRNCPAEVVQCTQRATLQNGVVTGGPLILSFPTLMRRAPRAGEHDIVLGAADLAIIGARPRPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W6PZJ7</accession>
    <name>W6PZJ7_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">chitinase</fullName>
            <ecNumber evidence="2">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PROQFM164_S01g003490</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the glycosyl hydrolase 18 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="2"/>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PZJ7"/>
    <dbReference type="STRING" id="1365484.W6PZJ7"/>
    <dbReference type="OMA" id="GTTCFAY"/>
    <dbReference type="OrthoDB" id="2425929at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050542">
        <property type="entry name" value="Glycosyl_Hydrlase18_Chitinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45708">
        <property type="entry name" value="ENDOCHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45708:SF49">
        <property type="entry name" value="ENDOCHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="6 8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 8 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH18" evidence="11">
        <location>
            <begin position="1"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="265"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="265"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="361"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="412"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDM29678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="463" mass="48860" checksum="F23D821451D2A6A9" modified="2014-04-16" version="1">MAFNMMVNGPGGAPEIDFSVTSKDCDVFEGTELKNCPSIAKDIQTCQKKNKTILLSIGGATYSEGGFKSDEDAKDGAKLMWETFGPKKENSTALRPFGDAALDGFDLDFEANVQHMAPFANELRSLMKADKSKQDFYLTSAPQCPYPDEADKEILNGPVYIDAIWVQFYNNYCGVNNFNTDSSSNKYNFEEWDTWAKTVSQNKDVKVIVGVPAFTSAASTGYIPASELAKVIEYTKKFDSFGGVMMWDATQAYENDGFIEDVRESLGSANDSGSSSPDPVSTSASASTSTDPTKTTTTTTTTTTTTTTTTTTTRTTTTTTTSPSSNAPVSSHSSSSSSSASASHKGAEETTTTTTKEHKPTVTTTTQKPVASTTQPKPTTIVTTTAKPKASSTTSAETTATPTSNGGPNSPSDDDNSDDGPNDESGSNLLGSILGNDLLGLLGGLRKANKAASGITHGLANNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W6PZP2</accession>
    <name>W6PZP2_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="8">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PROQFM164_S01g003332</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the tannase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="8"/>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PZP2"/>
    <dbReference type="STRING" id="1365484.W6PZP2"/>
    <dbReference type="OMA" id="LCQWPSR"/>
    <dbReference type="OrthoDB" id="3039123at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030600">
        <property type="term" value="F:feruloyl esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011118">
        <property type="entry name" value="Tannase/feruloyl_esterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33938:SF7">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33938">
        <property type="entry name" value="FERULOYL ESTERASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07519">
        <property type="entry name" value="Tannase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005151036" description="Carboxylic ester hydrolase" evidence="8">
        <location>
            <begin position="22"/>
            <end position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM29520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="579" mass="62568" checksum="91B1B76E3249FB09" modified="2014-04-16" version="1">MRVSLGAAAALAASAGATSLADVCTVSNVQAALPSNGTLVGISMIPSAVTASAVYNATAGTGSTETYTYCNVTVTYEHTGKGDSVVIKYAFPKPSDFKKRFYVAGGGGFSLSSDATGGLEYGAVSGATSAGYDAFNYAYDDVVLYGNGSINWDATYMFGYQALGEMTKIGKVLTQGFYGMSSSAKVYTYYEGCSDGGREGMSQVQRYGEEYDGAITGAPAFRFAQQQVHHVFPATAEQTLDYYPPPCELAKIVNATITACDPLDGRTDGVISRTDLCKLKFNLTSIIGEEYYCAAETSTSLGFGFSKRADGTSTSTTPEQSGNVTAEGVKVAQAVYDGLHNSQGERAYLSWQIGSELSDADTQWNNESSKWEIDIPSTGGEYVTKFIQLLDLDNLSDLDNVTYDTLVEWMNIGMVRYLDSLQTTLPDLTPFQASGGKLLHYHGESDPSIPAASSVHYWQSVRAIMYPNLSSQESLKELADWYQFYLIPGAAHCGTNSLQPGPYPENNMQTMIDWVENGVKPSRLNATVSSGTYEGETQMLCQWPARPLWKSNSTFKCVDDTASIESWTYSFPAFKLPVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q0G9</accession>
    <name>W6Q0G9_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Guanylate kinase</fullName>
            <ecNumber evidence="2">2.7.4.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">GMP kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">GUK1</name>
        <name evidence="10" type="ORF">PROQFM164_S02g000182</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the guanylate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.8" evidence="2"/>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q0G9"/>
    <dbReference type="STRING" id="1365484.W6Q0G9"/>
    <dbReference type="OMA" id="EWAVVHG"/>
    <dbReference type="OrthoDB" id="6334211at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004385">
        <property type="term" value="F:GMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00071">
        <property type="entry name" value="GMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000776">
        <property type="entry name" value="Guanylate kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008145">
        <property type="entry name" value="GK/Ca_channel_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008144">
        <property type="entry name" value="Guanylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017665">
        <property type="entry name" value="Guanylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020590">
        <property type="entry name" value="Guanylate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03263">
        <property type="entry name" value="guanyl_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23117:SF13">
        <property type="entry name" value="GUANYLATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23117">
        <property type="entry name" value="GUANYLATE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00625">
        <property type="entry name" value="Guanylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00072">
        <property type="entry name" value="GuKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00856">
        <property type="entry name" value="GUANYLATE_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50052">
        <property type="entry name" value="GUANYLATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Guanylate kinase-like" evidence="9">
        <location>
            <begin position="6"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDM30033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="197" mass="22126" checksum="E956A67E01781CBE" modified="2014-04-16" version="1">MASAAYRPIVISGPSGTGKSTLLKRLFAEYPEKFGFSISETTRSPRPGEQHGREYNFVTKEAFLDLVANNGFIEHAQFGGNYYGTSVQAVKNIAEKKRICILDIEMEGVKQVKLTDLNARFLFLAPPSLEVLEQRLRGRGTETEESLQKRLTQAQNELEYAKLPEAHDRIVVNDDLEKAYVELRDWVVDGGKFGVAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q0L4</accession>
    <name>W6Q0L4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S02g000237</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q0L4"/>
    <dbReference type="OrthoDB" id="529273at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM30088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="85" mass="9987" checksum="AD88AABB0A7EBBE9" modified="2014-04-16" version="1">MLHLGEALEYSVHSDYLFLDCQVVYMYSVDFGNSADPEISVKMPRQLLRFDDTEPRQSQKITLTFINRVSGRKLANQEQYLERLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q1P2</accession>
    <name>W6Q1P2_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Winged helix-turn-helix transcription repressor DNA-binding</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PROQFM164_S02g000379</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q1P2"/>
    <dbReference type="STRING" id="1365484.W6Q1P2"/>
    <dbReference type="OMA" id="WPTPQVA"/>
    <dbReference type="OrthoDB" id="340227at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045727">
        <property type="term" value="P:positive regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07323">
        <property type="entry name" value="LAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045180">
        <property type="entry name" value="La_dom_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006630">
        <property type="entry name" value="La_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22792:SF132">
        <property type="entry name" value="LA-RELATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22792">
        <property type="entry name" value="LUPUS LA PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05383">
        <property type="entry name" value="La"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00715">
        <property type="entry name" value="LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50961">
        <property type="entry name" value="HTH_LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="HTH La-type RNA-binding" evidence="4">
        <location>
            <begin position="576"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="671"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="786"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="24"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="83"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="168"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="182"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="220"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="255"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="326"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="360"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="382"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="406"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="461"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="489"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="687"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="795"/>
            <end position="805"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDM30230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="951" mass="103371" checksum="C02BDF5BEAA33B93" modified="2014-04-16" version="1">MSTFSYAQAAKGVSGTPALSKTPSESEKTDSKPEEHTTVETTTDEAPAPTESEPVQQPEVVAEENKDDDFTTVTNKHAAKTKAINSRTSSPSVRTGSKARKSKEDDSHTPNGNADATAEKQAPSEGQTEKAEGAAEKSAEKSEDSEKIASPPKELKAAPLPSVNIWQQRREAQDAKVKAVPKSTSTSKAASTKAASTADETQQDSKTGSKKKGADGAQEGAKDRKKTDGGKGRDAGSVPPVEDATAWPTPQVAIGEEKKKSHEKTEKSPVIRPHGKEKWTPVPYVPTAVFNTPLPSAGGRGGRRATRGGRDSGRGAHGNGTATTDKAASGQAAQGAKQSPGDRGRLESGSGRAASLPAQSRRSTSTDAGATADARKASQAPERGRGARNGEENNKQVNGGENGPRPQREGKPIGRSQDARAGDRNQKGANLAVDLQAAARGNDRRFEAGSKSADPTGLTDFSRERGEFRSERGGRGSNRGRGGAYANFGGQNAQFNASMSNNPFPAPKSFGFNERQRSHQHGLPNGAQQGNRMPLRSPSVPTPANMYGVVYPFPGDINTMYGYPAAPMSAVPYQQYVEPFSLMNMLSMQLEYYFSVDNMCKDMFLRKQMDSQGFVPLNVLASFKRVKSLTEDFELIRHVSRQLRNVECQTGEDGVDRLRPRDKWQQWVLPVDQREPAAQNEGAAPARKTDENTPVHGHSENVINGSARQFVPNGVAHDVKTSLSSTAPEFMPSLLPTAVNEIANSEPPFPFDLESMVSPTSSDADCFQYQVGGTDWLISKSFAEAHQPAPKSNGKGRSSTQTSNYVPKTFNMSRKETFDGRGRQMSRRYSIGMTQPYESWSFSLTKNFNSHLYNEFRRSALDDLLTRHVDNGFNELMEFYRNCLLHRRHIPDLVLYDMVYLSQGQTSDYHTLVSNTIHETIASGKMKLHNWGRISKYFDTQLGKTAGEKLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q276</accession>
    <name>W6Q276_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S01g002095</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q276"/>
    <dbReference type="STRING" id="1365484.W6Q276"/>
    <dbReference type="OMA" id="FYAVSNQ"/>
    <dbReference type="OrthoDB" id="5359231at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM28284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="625" mass="71463" checksum="4BFBB27396D8B791" modified="2014-04-16" version="1">MSLDTLSYDVFYQIATLLDDCDFINLSRTSRALYHLSRSEQIARKTVENVFRYSKEGQAALAAQSGFRQAVGHRLAIHEAVATANPYSAVCVGYGSEFLYNQGHLCYRSDHWIRLLYLHGTVFRERVMDLRDAIPRLLETGPVEPGAEDRVTLLSYSDDILIFRVADANATEDALLVVNMAWREYHQGRSRFLLHEPIPASAPVFVRHCGTYIWYGIFMAGDGSAEGSWSITGVDLQSYEGINFELDRVVAGDLGQTLCFEMHGEYLYAVSTQDAADDDVHSSFYYWFCQAPRDEYRRWKGRLWRREHQEGPINEMWTDLSIRTDERTGRPVILECRREWRDGKSENHRTYYTQPLPTPEEALAPLVEGATQSPCWVSMDAEHPYNDRPAKRLRRHYHAEYEPGSTMRQEFIAARTKHKSYHLGASSFVDIVNDPVGDNLRSRDRIRLRTVSRKRKCPIDEEGIEGPRNQLFQPTQVDQDGYPVEGSEERFECRGVYMWPPEDAPPALQQLLCPGPRTGSVKSIADDCSIIYSIDAPGLPPNQQALVLISFDPNFQLPITTPLPTATSPADHWAPRELFPQTLKPPPPYFPSRNLVEEAPPFFLGIRRGYYLRGIRDPYWKGLVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q2M7</accession>
    <name>W6Q2M7_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Obg-like ATPase 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PROQFM164_S02g000385</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Hydrolyzes ATP, and can also hydrolyze GTP with lower efficiency. Has lower affinity for GTP.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q2M7"/>
    <dbReference type="STRING" id="1365484.W6Q2M7"/>
    <dbReference type="OMA" id="VLRCFDN"/>
    <dbReference type="OrthoDB" id="424823at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04867">
        <property type="entry name" value="TGS_YchF_OLA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01900">
        <property type="entry name" value="YchF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.300:FF:000001">
        <property type="entry name" value="Ribosome-binding ATPase YchF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000001">
        <property type="entry name" value="Ribosome-binding ATPase YchF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.300">
        <property type="entry name" value="TGS-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00944">
        <property type="entry name" value="YchF_OLA1_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004396">
        <property type="entry name" value="ATPase_YchF/OLA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023192">
        <property type="entry name" value="TGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013029">
        <property type="entry name" value="YchF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041706">
        <property type="entry name" value="YchF_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00092">
        <property type="entry name" value="redox-regulated ATPase YchF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23305">
        <property type="entry name" value="OBG GTPASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23305:SF11">
        <property type="entry name" value="OBG-LIKE ATPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06071">
        <property type="entry name" value="YchF-GTPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006641">
        <property type="entry name" value="CHP00092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="TGS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="4">
        <location>
            <begin position="21"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="TGS" evidence="5">
        <location>
            <begin position="306"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="30"/>
            <end position="35"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDM30236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="394" mass="43780" checksum="6A724FE6C3904558" modified="2014-04-16" version="1">MPPKKQQVQEKVLLGRPGNNLKSGIVGLANVGKSTLFQSITKSSLGNPANFPYATIDPEEARVIVPDERFDWLCQHYKPKSQVPANLTVYDIAGLTRGASTGAGLGNSFLSHIRAVDAIFQVVRCFDDAEIIHVEGDVDPCRDLTIINEELRIKDIEFVEKALDLLGKQTRRGGQSLEMKKLKEEEATTAKILQFLKDGNDIRKGDWTPKEVEVINPLFLLTAKPVVYLVNLSERDYIRQKNKYLPKVFEWIKTNSTGDPILPVSAQFEERLTLMHDDAAAEAECKTLGTKSGLPKIITTMRQSMNLGSFFTTGEDEVRQWTIRKGIKAPAAAGVIHTDFEKTFIQAIVYNYASLREYGDENAIKAAGKIMTKGKDYVVEDGDILLIKAGAAKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q2Q4</accession>
    <name>W6Q2Q4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="12">AAA+ ATPase domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PROQFM164_S02g000760</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q2Q4"/>
    <dbReference type="STRING" id="1365484.W6Q2Q4"/>
    <dbReference type="OMA" id="IRARITM"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042626">
        <property type="term" value="F:ATPase-coupled transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002145">
        <property type="entry name" value="ABC transporter (MsbA subfamily)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF345">
        <property type="entry name" value="ABC MULTIDRUG TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="76"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDM30610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="341" mass="37355" checksum="A9FB946A3C07BD9E" modified="2014-04-16" version="1">MVLDLFIAGIAIILVALVTNISGSGSTGYLGVALYQIVTFSTSLQTLVTEWTQIEMALGAISRDMSATNGPQKGAIVFNGFTVSYDTSTDPVLKNINLSITPGENVAICGRTGSGKSSLVSTLLRMLELQLGSICVDDIDISTITRQAVRARFNSLPQDPFFLQGTVRENLDPLRVSTDERLVQALQSVRLWDFCESRGGLDEDMNEGTLSHGQRQLFCLVRAVINPSSVLIIDEVGGSVEADTETLIHEVLQKEFEACTVIVVVHKLHTTLDLDRFVVPNKGRIVEAHRVSCLNGQDHCSRRYMTACRQTRGSSRIEAPPPRLGDPKGPTLRAIWHWHAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q3K2</accession>
    <name>W6Q3K2_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 8">mRNA 3'-end-processing protein RNA14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">rna14</name>
        <name evidence="11" type="ORF">PROQFM164_S02g000690</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 8">Component of the cleavage factor IA (CFIA) complex, which is involved in the endonucleolytic cleavage during polyadenylation-dependent pre-mRNA 3'-end formation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Nucleus</location>
        </subcellularLocation>
        <text evidence="8">Nucleus and/or cytoplasm.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q3K2"/>
    <dbReference type="STRING" id="1365484.W6Q3K2"/>
    <dbReference type="OMA" id="VQLWSVY"/>
    <dbReference type="OrthoDB" id="26282at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0180010">
        <property type="term" value="P:co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.1040:FF:000006">
        <property type="entry name" value="CFIA complex component Rna14, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045243">
        <property type="entry name" value="Rna14-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008847">
        <property type="entry name" value="Suf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19980:SF0">
        <property type="entry name" value="CLEAVAGE STIMULATION FACTOR SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19980">
        <property type="entry name" value="RNA CLEAVAGE STIMULATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05843">
        <property type="entry name" value="Suf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 8" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Suppressor of forked" evidence="10">
        <location>
            <begin position="254"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="640"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="888"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="29"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="96"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="135"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="168"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="226"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="933"/>
            <end position="946"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00026188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU369035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDM30541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="1015" mass="113387" checksum="B84BBF97B0929038" modified="2014-04-16" version="1">MADDEAEAAFFQAQALNPDSQSPTKEQEGDNSDAESDDYDPSLALGDHYSVSLPESKQPGAGPTDAAPSDEPEDPIPNPTVAPDADVASEVDADAGQTSDSPDPSQNPSRVESSTPVPASTAEPQSKTRIIGGFEVDDDEDDEGDAEYEPPAVLGGEDVNAMPVTMSEDPSSGNAMQNTSPDVSSHHAEQAPASGPDVANSSYSPDPVHNIDPSSVPGQSHWAAQDLQSATMQNSTVPTSVPDSPASKGRLAHDRVGMLEDRIREDPRGDIPAWLELIAEHRSRSRLDSARDTYERFLKLFPMAADQWVAYASMESELNEFFRLEQIFNRTLLTTPSVQLWSVYLDYIRRRNPLTTDASGEARKTISSAYDMAIQYVGMDKDSGNIWADYIEFIRSGPGIVGGSGWQDQQKMDLLRKAYQRAIGVPTQAVNTLWKEYDQFEMNLNKLTGRKFLQEHSPSYMTARSSYTELQNITRDLIRTSLPPLPPLPGSEGDVEFSAQADIWKRWLAWEKEDPLVLKEEDPAAYKSRVVYFYKQALMALAFLPEMWFDAAEFCFLNDMEDAGTEFLKNGIDANPESCLLTFKRADRLEVTSDSEQDSAKRAAKVREPYDKLLDALYELINKARNQETQDVARIEAYFAPQNVESQPQNEDDDDPEAKEREAAKTAQIDAVRKAHSVQINIISKTVSFAWISLMRSMRRIQGKGKPGELAGSRQIFAEARKRGRITSDVYIASALMEYHCYKDPAATKIFERGAKLFPEDEHFALEYLRHLLDINDTINARAVFETTVRKLTSNPENVYKAKPIFSFLHEYESRYGDLTQVINLENRMRELYPEDPVLEQFANRYSNSNFDPTSVQLILSPSQTRQKTNMAGISAEYHGSPMARYMDTSLNSPKRPYPTDEYDEDSGRPRKFVRAESPMKSAQARRLDQPKRVQQLNGQSTSYRPQGSPAPLPREVVNLLSILPSAATYNITRLSPEKMIDLLRHVDIPSDISQIQIPQAAHGGGQNPYSGGYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q444</accession>
    <name>W6Q444_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA polymerase delta, subunit 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S02g001523</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q444"/>
    <dbReference type="STRING" id="1365484.W6Q444"/>
    <dbReference type="OMA" id="HYGPCTG"/>
    <dbReference type="OrthoDB" id="337486at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043625">
        <property type="term" value="C:delta DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000731">
        <property type="term" value="P:DNA synthesis involved in DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007218">
        <property type="entry name" value="DNA_pol_delta_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14303">
        <property type="entry name" value="DNA POLYMERASE DELTA SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14303:SF0">
        <property type="entry name" value="DNA POLYMERASE DELTA SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04081">
        <property type="entry name" value="DNA_pol_delta_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM31373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="184" mass="20686" checksum="88A95AC488E25DED" modified="2014-04-16" version="1">MPRRASNTPRSQSTLSFGARARVTKPVTAPSHKAKALDSTPALSDKSASTPEPQQLSVTPKEPSKPHVAELAVRQQAAVEHQAPRSEEDNRALKLNKQDIWRYWRAQEQARKTPSAHQQGMDVEEKILRHFDLSSQYGPCIGIARVKRWRRANQLKLNPPIEVLAVLLKGKDISERAYIDELLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q4K5</accession>
    <name>W6Q4K5_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF2293 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S02g001723</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q4K5"/>
    <dbReference type="OMA" id="DAREQVW"/>
    <dbReference type="OrthoDB" id="5381833at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018744">
        <property type="entry name" value="DUF2293"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38113">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38113:SF2">
        <property type="entry name" value="DUF2293 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10056">
        <property type="entry name" value="DUF2293"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2293" evidence="2">
        <location>
            <begin position="165"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM31573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="264" mass="30069" checksum="6563FD6282AA4BE6" modified="2014-04-16" version="1">MAPTTKPKVRKRKPRARKKNRGVRTREGHARPIDAGSPAQPLAEVLNEKTKRRKPKKTWAALIPVSDDPLERNIVEQVPLPDGYVLVPKGDVYITRHCRSKTKESERIVYVVYPQNRTGKRTLGIRVPEEIYTEVLESAAATKESRANAVQVRDAKDLSKSRELLKSEFPLMPKETLKIVLEHAFLKGSGRVGRTGMISDDRKTLLAVEAHIRHVHTPYEKLLEEGVSRKDAREQVWPTIQAVERTWQGCEKRKTTLALRPVDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q5K1</accession>
    <name>W6Q5K1_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Multiprotein-bridging factor 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">mbf1</name>
        <name evidence="10" type="ORF">PROQFM164_S02g002104</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Transcriptional coactivator that stimulates GCN4-dependent transcriptional activity by bridging the DNA-binding region of GCN4 and TBP (SPT15), thereby recruiting TBP to GCN4-bound promoters. Involved in induction of the ribosome quality control (RQC) pathway; a pathway that degrades nascent peptide chains during problematic translation. Required to prevent stalled ribosomes from frameshifting.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MBF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q5K1"/>
    <dbReference type="STRING" id="1365484.W6Q5K1"/>
    <dbReference type="OMA" id="GKNKSCK"/>
    <dbReference type="OrthoDB" id="10253401at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.260.40:FF:000030">
        <property type="entry name" value="Coactivator bridging factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013729">
        <property type="entry name" value="MBF1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10245:SF15">
        <property type="entry name" value="ENDOTHELIAL DIFFERENTIATION-RELATED FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10245">
        <property type="entry name" value="ENDOTHELIAL DIFFERENTIATION-RELATED FACTOR 1 MULTIPROTEIN BRIDGING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08523">
        <property type="entry name" value="MBF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="9">
        <location>
            <begin position="87"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDM31953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="154" mass="16714" checksum="1ECC6D6C8165A326" modified="2014-04-16" version="1">MSDWESTTKIGSKFRGAGAQPREVVVKGKSALNAAQRSGGVITEKKYTTGNISAKAGAPEGQHLTKVDRSDDIVKPKTIGHAVADAIKRRRTEEGYKMTQKELATKCNTTITIVQDFERGTAAPDQKVLGAMERVLNIKLRGSDIGSEKFPKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q681</accession>
    <name>W6Q681_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Calcium/calmodulin-dependent/calcium-dependent protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PROQFM164_S01g003577</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q681"/>
    <dbReference type="STRING" id="1365484.W6Q681"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF288">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="86"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDM29764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="300" mass="34082" checksum="4A9A4D109EC00F1C" modified="2014-04-16" version="1">MSEGMPPICRLDFKSFQDWNGDRPSQTLTFHNNDSSWWIKVTVDWSLPEQVLSLGYLKRRVKTRSLYGMGIKTQRTSSLPLPIECTARLRKIQRGSYTRRERCLPTFEARCLHTVEVIAPTVSIVVFEQRLFAYKTIDRPIYEPEGTNHVLNEINVLAQLRGLPSIAQLVSLVVSENPYKTCPSTAMPTVITGFLLEYYSGGSLEQIFEDEFQFDTLPVQWALQIGTALNTLHKRGRTHLDIKPSNIVLDANKNAVLIDVSGTGGYVWEWRSTEMQVVIQQNSETSPANTPFEARVATDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q6G8</accession>
    <name>W6Q6G8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S02g001756</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q6G8"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004879613" evidence="1">
        <location>
            <begin position="18"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM31606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="72" mass="7434" checksum="602B9D0E46030C09" modified="2014-04-16" version="1">MRLTVLLYAALAGLSLAAPAEPAEAADAAALDKRQASCVTIRNQLASCEAEGNCGTVMAQCIALHCQHCANF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q7K4</accession>
    <name>W6Q7K4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S02g002864</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q7K4"/>
    <dbReference type="OMA" id="LHAICYA"/>
    <dbReference type="OrthoDB" id="4282352at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="300"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="303"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM32713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="377" mass="42821" checksum="097FC64E6EDD645F" modified="2014-04-16" version="1">MDYPTLPSLISRPPRRQRRVSQDAEDQSKLGTHLQQSSNGTNIEAKSPVTPRALTVEFMKLLHYNDTLVIPALKLLDLYSSLWECYVIKSAEKMQFEDKQRQLLESNEWLASDSDILLQLCDEQAMELRDRKLALQALCNEEAHATADHDLDLDLHAICYAGTRNVYIGSMFVGGNRRPRLPISGSTTPLVLCIIVIDYVYELVGKPTFGLPPFVTINYEQKHGISGSWTMHRIGVTSKSDDQIHEAAQETISKMPQAYHVLDNNCQHFVVNLADAILRDPRHKYLSVKGQFISAHEIGVQPERSEPTQDEQNFKGKQDFQEDGDIEEGNPVPITDRDAEGAVIENEKERRKMMLKSIADFMADNTPLIQEREVIYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q7N3</accession>
    <name>W6Q7N3_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ubiquitin thioesterase OTU</fullName>
            <ecNumber evidence="11">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PROQFM164_S02g002526</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Hydrolase that can remove conjugated ubiquitin from proteins and may therefore play an important regulatory role at the level of protein turnover by preventing degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="11"/>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q7N3"/>
    <dbReference type="STRING" id="1365484.W6Q7N3"/>
    <dbReference type="OMA" id="TRCILVY"/>
    <dbReference type="OrthoDB" id="65596at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22745">
        <property type="entry name" value="OTU_OTU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17059">
        <property type="entry name" value="Ubl_OTU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.80:FF:000016">
        <property type="entry name" value="Putative ubiquitin thioesterase otu1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000096">
        <property type="entry name" value="Ubiquitin thioesterase OTU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048857">
        <property type="entry name" value="OTU1_Ubl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003323">
        <property type="entry name" value="OTU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057766">
        <property type="entry name" value="Znf-C2H2_OTU1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13312">
        <property type="entry name" value="HIV-INDUCED PROTEIN-7-LIKE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13312:SF0">
        <property type="entry name" value="UBIQUITIN THIOESTERASE OTU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02338">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21403">
        <property type="entry name" value="OTU1_UBXL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24560">
        <property type="entry name" value="zf-C2H2_OTU1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50802">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 11" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="7 11" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="OTU" evidence="13">
        <location>
            <begin position="130"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="78"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDM32375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="333" mass="36353" checksum="926B13A525611189" modified="2014-04-16" version="1">MRIRVRGPSGQSTVTLDDTATIEDLQTQIAEKTGLAAFDVKYGYPLKPLELDSFQPDQRILEVGINLNGESLIVAQKEGASRGVSDDAPIARTAPPQPSQPSQPSLSQRRPENTAEDPPEIASPEHAGTFVLRVMPDDNSCLFRAVGSAVMGDMDTMVELRSIVAGAIQSNPSEYTAAILGKKPDEYCTWIQNEDSWGGAIELKILSEYFNIEICSIDVQTLHMFQFNEGAPTRCIVVYSGIHYDVLALSPSHPPYTRANPLAHDDTKIFEAVDPVVLQRAKELCQVLQSKHYYTDTSGFTVRCNVCGGKFTGEKGATKHAAETGHYDFGEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q7N9</accession>
    <name>W6Q7N9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Sucraseferredoxin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S02g002172</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q7N9"/>
    <dbReference type="STRING" id="1365484.W6Q7N9"/>
    <dbReference type="OMA" id="VHPESQL"/>
    <dbReference type="OrthoDB" id="10253744at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03062">
        <property type="entry name" value="TRX_Fd_Sucrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009737">
        <property type="entry name" value="Aim32/Apd1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31902">
        <property type="entry name" value="ACTIN PATCHES DISTAL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31902:SF8">
        <property type="entry name" value="SUCRASE_FERREDOXIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06999">
        <property type="entry name" value="Suc_Fer-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM32021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="290" mass="32149" checksum="B383CA08088F5B76" modified="2014-04-16" version="1">MLRSLLSLGRAGTNDYLFPKVDPKTDGPECLNDCADCTVKFPSKVKVETSRPLYGDIKEFQTHVLVATGQSDWKEKNVENTTGSLMEAFDGAKSDHGRIKVSASNLTPPEQPTTDESPTQATTVLILPSFTYVDSVTQKDVPDLIARYIDHPSDQQNGSPANGMNARACELDYVVLLCSHGRRDARCGITAPLIKRELERQLRPLGLDRDPDDSRVGGVGIFFVSHVGGHKFSANVLIYRKKDQQMIWLARVRPEHCEGIVKYTILQGKVVHPESQLRGGFDRVKGLTSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q7Q5</accession>
    <name>W6Q7Q5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Heat shock protein DnaJ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PROQFM164_S02g002571</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q7Q5"/>
    <dbReference type="STRING" id="1365484.W6Q7Q5"/>
    <dbReference type="OMA" id="RANHEES"/>
    <dbReference type="OrthoDB" id="5894at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051964">
        <property type="entry name" value="Chaperone_stress_response"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022755">
        <property type="entry name" value="Znf_C2H2_jaz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054076">
        <property type="entry name" value="ZUO1-like_ZHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44029">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44029:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12171">
        <property type="entry name" value="zf-C2H2_jaz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21884">
        <property type="entry name" value="ZUO1-like_ZHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0346">Stress response</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="J" evidence="6">
        <location>
            <begin position="23"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="311"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="497"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="286"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="412"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="295"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="426"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="477"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM32420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="536" mass="60795" checksum="1400A63645B29F64" modified="2014-04-16" version="1">MGQFHSTSQASSGASEQTEQKTDYYELLGVIRGATDEEIKKAYRKKALILHPDRNYGNVDEATKLFAEIQSAYEVLADPQERAWYDSHSDAFLGTNGNTDDQHSYNVRITTAEDVLRLFSKFSPQMEFSDSPTGFFGGLREQFEQLVVEERLACQWENQDPIEYPSFGSGDDDFETVVRPFYAAWTGFSTQKSFAWKDAHRYSEAPDRRVRRMMEKENRRLREEGIREFNDAVRSLVAFVKKRDPRYKVNAQSEAQRQETLRQSVAAQAARSRAVNQARMRDHVLPEWAQSEQPVADDDQERSEESEVESFECVACHKYFKSQKQFEAHERSKKHLKAVKQLCWEMRMQNDELDLESADDSGTNAVATKPLDDVDVGEYKVSAASEVDVVSDASLESHDIDAEDREISHGLEETIPLSELSSPTSSHDDDYASREYVETRLRTDMDSLSTGAGDSSDIPGRPFSSDLTEQSPTLKMGKAKQKRAKKAARQADQPTGFICANCQAPFTSKSKLFDHIRDLDHAQPLKGSLAKKGRKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q7Y1</accession>
    <name>W6Q7Y1_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Phytanoyl-CoA dioxygenase domain-containing protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">Phyhd1</name>
        <name evidence="5" type="ORF">PROQFM164_S02g002262</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM164</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PhyH family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q7Y1"/>
    <dbReference type="STRING" id="1365484.W6Q7Y1"/>
    <dbReference type="OMA" id="KYSEDNW"/>
    <dbReference type="OrthoDB" id="445007at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20883">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE DOMAIN CONTAINING 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20883:SF15">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDM32111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="310" mass="34013" checksum="78F47A713066640C" modified="2014-04-16" version="1">MAGLTETQVASFKENGYLVLPNYLAPTEVTALLAETNKLLEEFPLESHPLTQFTTGDETADHVGDDYFLNSGDKIRFFFEPDAFSTEPDPVTGRAALLKPKNRAVNKIGHSLHTLSPPFKAISLNERNAAVARSLGFVDPRVLQSMVICKQPSIGGAVPSHRDSEFLYTDPPSAVGWWYALQDAGPANGTLGMYKGSHTGRKGGHIARRFVRRENGAGTEFIENRGPALPKGMEEEKSEEATDEDLEILDIKAGSLVLIHGNVLHKSEKNTSLNSRYAYTFHVIEGADGWEYDVRNWLQPPAGGFSKLNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q807</accession>
    <name>W6Q807_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="8">AMP-dependent synthetase/ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PROQFM164_S02g002671</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the NRP synthetase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1365484.W6Q807"/>
    <dbReference type="OrthoDB" id="416786at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05918">
        <property type="entry name" value="A_NRPS_SidN3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19542">
        <property type="entry name" value="CT_NRPS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19534">
        <property type="entry name" value="E_NRPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19545">
        <property type="entry name" value="FUM14_C_NRPS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.10:FF:000016">
        <property type="entry name" value="Nonribosomal peptide synthase Pes1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.30:FF:000002">
        <property type="entry name" value="Nonribosomal peptide synthase Pes1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000015">
        <property type="entry name" value="Nonribosomal peptide synthase SidD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1200.10:FF:000005">
        <property type="entry name" value="Nonribosomal peptide synthetase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45398">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45398:SF1">
        <property type="entry name" value="ENZYME, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Carrier" evidence="7">
        <location>
            <begin position="1035"/>
            <end position="1111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM32520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="1975" mass="219343" checksum="7489E68F14066412" modified="2014-04-16" version="1">MGIQHLEHSMRPSTDMPATGVITPPGDSLEETLISFKKGTFIPSPSTEEENEVDEIWRQVADQCHCSLEEIEDVYPCTALQEAMIALTFKDPRAYTIEHEYHLPREIDHHKLQEAWITTAQANPILRTRMIPTSQRGCMQAVVRGSIPWQVQETDDGINGEISSPSWRAGAPLAYFFFNVTEYKLKVIIHHSICDHWSMALLLRQADAAYRDEELAFHPFRPLVDHVQQTQDKANDFWRSMFRDAHEATMVAFPQLPTVGHSARPTERLERSFSIQSGSGSSSTVGTKIRLAWAILQSVYTGSDDTLFGAVNAGRAVSVAGVQDLSGPALASVPVRIKLCGKNTVADALIEVQDEWAASMEFEHVGLQNLLRLGPGPAAACHFQTLLSVEPRDGHQLPDIFSQSRSTQVAYDMYPLVLRCRPSAVTMWIEASFDPAATEVCQMERILSQFIHIYEQIDTKPGLTLSNISAVSPEDLSDLRRQNILTKRPDVIPCVHSLIESRTRQQPFAPAISSWDGSYSYQVLDDLSSALADHLSWHRVGPGSFVPLLLGKTKWMAVAMLAVMKSGAAFVLLEPSHPQSRLRNMCEAVAAPLVLTCGWHIALAAELGVQALLNVDTFDPEQVQCNSSSQRSAISPQDPVYLTFTSGSTGTPKGVIVHHEGFASSSVAHGKPYHFTPESRVLQFASPAFDSCIIEHLSTLIQGGCVCIPSTDDCHGHLVESMNRFEVDVACLTPSVTRIISPDSLKSLKVLMFVGEAVLASDVLRWEPFVHVGNAYGPAECSAVFSVQPNLKSNDPANIGFSTGGSGWVVHPEDHRVLMPLGCTGELLIEGPIVGKGYLSNLEQTARVFVEAPPWRLQFGSPPSGKLYKSGDLVQATGDGSFRYLGRKDTQVKLHGQRLELADIEYHLHRAFPKASQTLADVRRSFPRNSANEHRPEALLIAFICLPASPPDDDGSHQVEFLPPTDEFREACAAAETSMSDVLPSFMIPRFYLPLSHVPLTPSGKTNRRSIQEHANKLSLEQMKAYRAVKIQPEAPSTSREEKLQQIWANTLNRTVEEIGTTESFFRLGGDSVSAMQVAAGCRTVGLKVAVADIFRFPSIRQLAERIQDSGSVSFASAAEDDQTEVWFELSPIQKLFFERVPDGHNKFTLEFILRLDTPLPPPEIKRAIEKIVATHSMLRARFEKRADGQWGQIIGPDVSRSLRFREHRVPSMNDRKALQKIFSISQNTLDIVQGVMIVVDVITTDAGEQFLGLMAHHLVIDLVSWRVLLQDLEDILNTGRTIQPLSISFQQWSRLQQSYAQQSLDPSETLRTEIPRPSMDYWGPEASLGSNTWADATRRTITVSRETTEAIIGAANGAFHTQPVEIIQAAVLYAFVQAFENRPAPTMFSEGHGREPWDPEIDISRTVGWFTTIAPLFLDVKKEDNVRRILQMTKDGRRSISTNGWAYFASRFLHPEGPEKFKSHSPMEILFNYTGLFQQFERPGALLQMTSVQDDSLLPMAADLPRMALIDVNATVMNGSLNLSFIYNQQLQHQDRLDQWISNCQQTLEELPMELQQEQQLAAVDFPLLSLASEEHLHSLLHQVSGRFDVSPSGIEDMFPCSPIQLGMWLSQLRNPQVYWSHIRWSLHPTSANSSLDTNQVKQAWQQVVDRQPILRTVFADGVKGHGHPVQVVLRTCEANIKVLSGSELRAEGQVPSLSDEFLLNPKSSNTKGRPPHQLTVAIEPDGGAYCQLAIHHILVDGITEQRLLSEFHQACNGTLDAESAGSYSRYLSYLKTRDHRASESYWKEYLTDVHPCVFPSLGLKEHATAPSFLKSLPFSMSIGQDLSSFCRDHGITISSLLQVAWGVVLRAYTGSESVCFGYLNACRDIPVQDAHDISGPLINLLICRLSLADDSSVLSTLAENHAAYAQSLDHQHCSLAEVMHSLRRSGQPLFNTAMSLQKDAGNLFTDKSEKIKLQPEDGIDSTEVCEDTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q809</accession>
    <name>W6Q809_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SMAD/FHA domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S02g002282</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q809"/>
    <dbReference type="STRING" id="1365484.W6Q809"/>
    <dbReference type="OMA" id="RLADMAW"/>
    <dbReference type="OrthoDB" id="4096268at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051176">
        <property type="entry name" value="Cent_Immune-Sig_Mod"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15715">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 170 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15715:SF37">
        <property type="entry name" value="LD47843P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="FHA" evidence="3">
        <location>
            <begin position="32"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="138"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="474"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="705"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="157"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="477"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM32131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="809" mass="90367" checksum="EAC6DB870CC7A786" modified="2014-04-16" version="1">MSDPSATVTLVPLFEDLYPLRTLTITDNDKTVPIGRASKRENRNRNPTAENAWFESQVMSRDHALLKILPNQNMVFITDCGSTHGTFLNGGKLVTDVNTPLRNGDIIRFGVDVDQVFEPIEVSCKVEWLKPQHVVIPDDSISIKPDPSPSTNSFSVPEDDSDMEDTDLPSDDSSKESVARSWETTVLQPMNTSLVSPASSVQSVQSDEHSKDGCNSFWGTVFATKEPISKIVPDPTPLVPGLLGQLSDTKPVSDTNPSPAKLVSDAKIYLAESASAEIASEQQAHEDSLPAICYQQVPEIRYSDWTMMRPMFMRLADMAWGESNNIPDVDHDRHIIHAARRCSISQDSYWVDDTPSFRPCVGTEVYWEPDSEDSDTSFHRMPGNLLRYWSVDKRRYWVINEDEGGERVSNRWWIVEKPLELLSEDLKRELETETEVEDCHKCWIVRAWEPRMIGDRWCDVAPYWDPNFDENWLSDDQSVDSDEEAQEYEEYTTKSDALSDSSESYPRYPCLMYDSDSIHGDGCEMSDDLEEEDFEEDYAEDFEEDGEICDESENDSDCSDNGCLEHHIPQNPDIRSLLGPELVKKLERANNTDAVEVPEHVSAKPFEGQSLNPARIESKPLMGQAAPGMTNPGARFPTHTVSGELPSSCQNKYPPMQRKIESFVGVPSLSHEFKHPYHDGPFSTGYPAEDACLATFRKPHLKRTATEMESSALEASISQDAQRLPVEPTSQSDLDLNTISSEAKDAISSALAENVSAFAENERPAKRIKSNHSTSKSLASHATTAVISALLGGLGTIAVLASLPNEYFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q878</accession>
    <name>W6Q878_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Alpha-1,2-mannosidase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PROQFM164_S02g000593</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q878"/>
    <dbReference type="STRING" id="1365484.W6Q878"/>
    <dbReference type="OMA" id="TMVNPQN"/>
    <dbReference type="OrthoDB" id="449263at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000224">
        <property type="term" value="F:peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006516">
        <property type="term" value="P:glycoprotein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1610.10:FF:000002">
        <property type="entry name" value="Alpha-1,2-mannosidase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.98.10:FF:000010">
        <property type="entry name" value="Alpha-1,2-mannosidase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.60:FF:000002">
        <property type="entry name" value="Glycosyl hydrolase family 92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.60">
        <property type="entry name" value="alpha-1,2-mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1610.10">
        <property type="entry name" value="alpha-1,2-mannosidases domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2080.10">
        <property type="entry name" value="GH92 mannosidase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005887">
        <property type="entry name" value="GH92_a_mannosidase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041371">
        <property type="entry name" value="GH92_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012939">
        <property type="entry name" value="Glyco_hydro_92"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050883">
        <property type="entry name" value="PNGase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01180">
        <property type="entry name" value="aman2_put"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12143:SF25">
        <property type="entry name" value="FAMILY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G10790)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12143">
        <property type="entry name" value="PEPTIDE N-GLYCANASE PNGASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07971">
        <property type="entry name" value="Glyco_hydro_92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17678">
        <property type="entry name" value="Glyco_hydro_92N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004881852" evidence="2">
        <location>
            <begin position="20"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 92 N-terminal" evidence="4">
        <location>
            <begin position="33"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 92" evidence="3">
        <location>
            <begin position="286"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="786"/>
            <end position="805"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDM30444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="834" mass="91792" checksum="FC96719591B27067" modified="2014-04-16" version="1">MLPYLLLSLFSTSRILVNAADTPLLEDYDVLQYINPLIGSANGGNVFPGASLPYGMAKAVADTDSESNQGGFAHEGGSVTGFSSMHDSGTGGSPSLGNFPLFPYAKCAGDDVNGCVYPKNQRKTKYKPDSVQARPGYFAIELASGVRVDMTTAHHTSLFRFQFPSDNTTSPLILLDLTDLSNSRQDNATISVDNTTNRMTGDARFAPSFGSGSYMLHFCADFKSPAAQRDSGIFVNSRASADVHDLKISRSINGYPLPGGGFVRFESAADNTVLARVGVSFMSTEQACAHAESEIPNFDFNATHQIAVEKWTEKMRPIRVSRTNIDSSVLSNFYSGIYRTMINPQNYTGENPLWQSSEPYFDSFYCLWDSFRSQIPFLTIFDPSSVMQMVRSLIDTQRHLGWLPDCRMSLCKGYTQGGSNADNVLADVYLKGLRDGIDWDAGYAAVQKDAEEEPYDWSSEGRGGLRSWKELHYIPVEDFDYEGFGTMTRSVSRTLEYSYNDFAIAQMARGMNKTADAERYEKRSRYWQNLFKPNQASFWRGRDTGFTGFFQPKHINGTWGVQDPLACSNIDESGHACSLQNTAGETFESSIWEYQFFVPHDMQTLITLLGGPTNFVTRLDYLHDRNITYIGNEPAFLTVFQYHYAGRPAKSTSRVRAYIPDYFSPTPAGLPGNDDSGAMGSFVAMAMMGLFPNPGQSVYLLTVPFFESVSIVSPLTGKTATLRTVNWAEYNTANATGAAAGGNGFIQSATLDGVPYTRNWIGHDFFAEGRELVLVLGKEESAWGTGLEDLPPSLAPEAGSGGGDEDVNYRRWESVVESGQLGALHLDNHVDLVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q8F3</accession>
    <name>W6Q8F3_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S02g002811</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q8F3"/>
    <dbReference type="OrthoDB" id="4232419at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM32660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="56" mass="6345" checksum="DC057E393D7C2675" modified="2014-04-16" version="1">MVYIAYHAETMFSFNNLDNLCFADTKDNDSGIMPLDMEQEYVNDFDADREILGGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q8Z6</accession>
    <name>W6Q8Z6_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Probable transposable element</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S02g003290</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM33138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q8Z6"/>
    <dbReference type="OrthoDB" id="5379619at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM33138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="48" mass="5172" checksum="BC3F2200F4E11FD0" modified="2014-04-16" version="1">MFGSIKAQRIKCGRPCSITLVMLEALCDRLLEKPTIYAEACIQAGASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W6QB25</accession>
    <name>W6QB25_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Fimbrin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">SAC6</name>
        <name evidence="8" type="ORF">PROQFM164_S01g000721</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QB25"/>
    <dbReference type="STRING" id="1365484.W6QB25"/>
    <dbReference type="OMA" id="WQLMRKN"/>
    <dbReference type="OrthoDB" id="431378at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0032432">
        <property type="term" value="C:actin filament bundle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051017">
        <property type="term" value="P:actin filament bundle assembly"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051639">
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110009">
        <property type="term" value="P:formin-nucleated actin cable organization"/>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="entry name" value="CH_FIMB_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CH_FIMB_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21300">
        <property type="entry name" value="CH_FIMB_rpt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21303">
        <property type="entry name" value="CH_FIMB_rpt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000042">
        <property type="entry name" value="Fimbrin, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Plastin-3 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000016">
        <property type="entry name" value="Probable fimbrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000027">
        <property type="entry name" value="Probable fimbrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001589">
        <property type="entry name" value="Actinin_actin-bd_CS"/>
    </dbReference>
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        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039959">
        <property type="entry name" value="Fimbrin/Plastin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19961:SF18">
        <property type="entry name" value="FI19014P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19961">
        <property type="entry name" value="FIMBRIN/PLASTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00019">
        <property type="entry name" value="ACTININ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00020">
        <property type="entry name" value="ACTININ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="7">
        <location>
            <begin position="139"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="7">
        <location>
            <begin position="288"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="7">
        <location>
            <begin position="412"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="7">
        <location>
            <begin position="537"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00073963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM26912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="647" mass="72139" checksum="7D6A649184162B5B" modified="2014-04-16" version="1">MNVFKLQKRFPQLDQGEIFSLQDAFNRLDVEDRGYLDESTVIKAAQQSERQPYDVVRAALKDVELDSSRRVELEDYVDQLVSKLRTAPTEGVRAAATPAAVIQEAGAGPGASRHVSKGSVGGRIHVQGSSSNVTHTINEDERTEFTRHINAVLAGDPDVGNLLPFPTDTFEMFDKSKDGLVLAKLINDSVPDTIDERVLNKAGKKIKQLNAFHMTENNNIVINSAKGIGCSVVNIGSGDIIEVREHLILGLIWQIIRRGLLGKIDIKLHPELYRLLDEDETLEQFLRLPPEQILLRWFNYHLKNAKWDRRVTNFSTDVKDGENYTVLLNQLAPDICSRAPLQTRDLLERAEQVLQNADSLDCRKFLTPTSLVAGNPKLNLAFVANLFNTHPGLDPITEEEKLEVEDFDAEGEREARVFTLWLNSLDVQPAVNSLFDDLRDGSVLLQAYDKVIPGSVNWRHVNKPPASGGELMRFKAVENTNYSIELGKHNGFSLVGVQGADITDGQRTLTLGLVWQLMRRDITNTLSALAQRLGKREITDTEMIRWANDMSSSGGKSSTIRSFKDKSIGSGIFLLDVLNGMKSSYVDYDLVTPGRTDEEAYANAKLSISIARKMGATIWLVPEDICQVRSRLVTTFIGSLMATHEKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W6QB90</accession>
    <name>W6QB90_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Genomic scaffold, ProqFM164S03</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S03g000682</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QB90"/>
    <dbReference type="STRING" id="1365484.W6QB90"/>
    <dbReference type="OMA" id="CVDVESY"/>
    <dbReference type="OrthoDB" id="5953249at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040151">
        <property type="entry name" value="Gfd2/YDR514C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048519">
        <property type="entry name" value="Gfd2/YDR514C-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28083">
        <property type="entry name" value="GOOD FOR FULL DBP5 ACTIVITY PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28083:SF1">
        <property type="entry name" value="GOOD FOR FULL DBP5 ACTIVITY PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21762">
        <property type="entry name" value="DEDDh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfd2/YDR514C-like C-terminal" evidence="2">
        <location>
            <begin position="351"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="564"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="32"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="565"/>
            <end position="580"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM33958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="591" mass="66204" checksum="C238A581151E8501" modified="2014-04-16" version="1">MDVRERLKMLLEGDTGLNDLNTHLSQAEAVQPAPSADGADPGAGFTKAKQDVSQSYPEGGQFPLSYIRTYVVGDIGGSRDRPLTQINQRHPRRTPKMHIDIPGLNKRKDEGGGGISDLDCDEELVTAIPVTKSFTPATTMARFPFRYIPQNDAQSVNERFYEGDQFWNRTWDLYHLSVPMAISQTPFLLIPTSQAQALLDEINSALNLNLSLTGVDKDGLVIDIDNEMLPQPMYLGRTSTHARKKKLESIVPSPLENWGPHAHLVEPPVFEDFEKKIKQSIATTKIRKSCKQAVRDARIKKWQESLGRAQAYFGLCPPLKPNDTQPSFANGQIRPIDVLKPVNWAFQDAPIFICIDLEWMDRYGSLTEVGISTLDMMDLEGVVPGDYGHMWVKKIRSRHLRVKEHRHWVNVTYITGCPGRFGFGESEIVPSAEIPKVVDAAFQPPYMVSLEGEDIPRHKNAKRNVILVGLDLHGDIIHLQKAGSQVFTSLNEPSSVIRETIDVAELYRADAEENQKRGLRALLGSLNILSFDLHNAGNDAHYTLHALVRLMLRVAGEKPWAYELNGERNVESKDERKDQQGDPESEPKAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W6QBA3</accession>
    <name>W6QBA3_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g000791</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asaB hydroxylase/desaturase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QBA3"/>
    <dbReference type="STRING" id="1365484.W6QBA3"/>
    <dbReference type="OMA" id="KPWAKVD"/>
    <dbReference type="OrthoDB" id="412788at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044053">
        <property type="entry name" value="AsaB-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041278">
        <property type="entry name" value="CmcJ_NvfI_EfuI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34598:SF4">
        <property type="entry name" value="7ALPHA-CEPHEM-METHOXYLASE P8 CHAIN RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34598">
        <property type="entry name" value="BLL6449 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM26982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="296" mass="33625" checksum="3B4683F4062CD767" modified="2014-04-16" version="1">MTTAAFRYIDRASYDPDATEPFKKPWGKVDGPGRSYQLTELERKVEDLRGQESNFTTDNSGFALYKSPAKETAFTDDAEVRAGYYPEVEDLLRKKLPGVKKVAIFDHTIRRRVPGSARSPVQLVHVDQTPKAAEARVRRHLPEDEVEELLKGRYQIINVWRPIENPASDFPLALIDWRSIAPSDFVKVDLLYPKEWQEHGEVAPDSESFFSTDGYEVKGETYAIAPNQEHRFFYAKDMTPEEVMFIKCFDSRSHTMTGGKTDIAHGSGHTAFIDPQTPAGSPGRQSIEVRCLVFYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W6QBM1</accession>
    <name>W6QBM1_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Glucose-methanol-choline oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PROQFM164_S01g000866</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FM164</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QBM1"/>
    <dbReference type="STRING" id="1365484.W6QBM1"/>
    <dbReference type="OMA" id="KKYGTML"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF201">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE OXIDOREDUCTASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00623">
        <property type="entry name" value="GMC_OXRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0134">Cell wall</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 11 12" id="KW-0274">FAD</keyword>
    <keyword evidence="7 12" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="13">
        <location>
            <begin position="94"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="14">
        <location>
            <begin position="284"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="547"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="592"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="546"/>
            <end position="547"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS00623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CDM27057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="619" mass="68710" checksum="E95D7BA79F07AA66" modified="2014-04-16" version="1">MGNETLQQFAALDLDYLIIGGGTAGLAVAARLTEDTGFHVGVIEAGPSVLNIDDNGAINVPGRYGETIGSKYDWKFETTPQPGLGGRSLPWPRGRILGGTSALNLMAWNRGHRKDYDSWAELGNEGWGWEDLLPFFRRSENFHPPSAAHQKYYQSSYDPQANGTKGPLHTTHAKQYGPTHQYWHETLNNLGVPSTRDSLAGDNTGVWNMVCTIDPDSQERSYSASAYYHPISNRPNLHILTEATAMEILFNCDNDDWYAAGARVRWNGLEANIKAYEETIVCAGSVQSPQLLELSGIGDQEVLRAAGIEMKVHSPNVGENLQEHMMTATIFEISSTIPTRDDILKDPIQREAADRAYYASQAGPWTVMPCSVAYCPLSKILSPKECDELHTQAKEIARETGRTHDAILAGQFEYGHARGQIEYLFDLGNWSPYFVSEPGKKYATMLQMLQYPFSRGSIHIPAMGEHNYEKATIDDKPVIDPRYFLGPGEIDKKVMAKALRWGDRICQTKPLAKLIRRRVFPPPAKEADSEEKVYEEFVSNYTVTDWHPVGTCAMGEADGTNAGVVNDMLQVHGVYCLRVVDASIMPLQVGAHIQATVYAIAEKAAEMIIDDYFARNGPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W6QC43</accession>
    <name>W6QC43_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ankyrin repeat-containing domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S03g000370</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QC43"/>
    <dbReference type="STRING" id="1365484.W6QC43"/>
    <dbReference type="OMA" id="HEGNERT"/>
    <dbReference type="OrthoDB" id="1577640at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM33646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="221" mass="24258" checksum="A50FCA2DE921DF71" modified="2014-04-16" version="1">MRSACSADRDLTSGDPERPIFVVARFVVTQIELILSELPNELLLAVADKLESSGDIFALARTRTTLHKLLIPYLFRFDAARPQSDALYFAARLNRESVCRNALQAGANPMAKYNGDTVLHVAAEFDHDRIARLLLAMPSVNPNCKGYYGLTPLGLAVTAGSLRTLRLLVAHDGVDPQPIYQGRTPLIQAVMSKRVDIMRILLAAKGIDPEIPDHEGMSPLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2024-10-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W6QCK7</accession>
    <name>W6QCK7_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S03</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S03g000510</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QCK7"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM33786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="70" mass="8243" checksum="C5DFF8548CC2A9AD" modified="2014-04-16" version="1">MVNTVFVKMIDCQEARPKKAYKNRLRLNGRISIYILRYNDDRSMTTQEIEANLALLILARSETTFQIHLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W6QCT8</accession>
    <name>W6QCT8_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Mannan endo-1,6-alpha-mannosidase</fullName>
            <ecNumber evidence="4 10">3.2.1.101</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PROQFM164_S01g001228</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Random hydrolysis of (1-&gt;6)-alpha-D-mannosidic linkages in unbranched (1-&gt;6)-mannans.</text>
            <dbReference type="EC" id="3.2.1.101"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycosyl hydrolase 76 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.101" evidence="4 10"/>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QCT8"/>
    <dbReference type="STRING" id="1365484.W6QCT8"/>
    <dbReference type="OMA" id="QGMLWQK"/>
    <dbReference type="OrthoDB" id="4187847at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0008496">
        <property type="term" value="F:mannan endo-1,6-alpha-mannosidase activity"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="P:fungal-type cell wall biogenesis"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Mannan endo-1,6-alpha-mannosidase"/>
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005198">
        <property type="entry name" value="Glyco_hydro_76"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014480">
        <property type="entry name" value="Mannan-1_6-alpha_mannosidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12145:SF37">
        <property type="entry name" value="MANNAN ENDO-1,6-ALPHA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12145">
        <property type="entry name" value="MANNAN ENDO-1,6-ALPHA-MANNOSIDASE DCW1"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF03663">
        <property type="entry name" value="Glyco_hydro_76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016302">
        <property type="entry name" value="Man_a_manosd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 10 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0732">Signal</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004879737" description="Mannan endo-1,6-alpha-mannosidase" evidence="13">
        <location>
            <begin position="23"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="436"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="404"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="404"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009699"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00012350"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRNR" id="PIRNR016302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDM27417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="460" mass="50575" checksum="9AF0F9CDAE517C8D" modified="2014-04-16" version="1">MILSKWLATLLGGAFAVQGALAIDVNLDDETSLKNAAKTVATTMMDFYNARDSKDIPGKFDGTWWEGGSMFMTLIMYWFVSGDSQFNDAVQDGMYFQKGDDNFFPSNYSQYLGNDDQVFWGLAAITAAEFNYPERDGEPSWVSLAQGVFNTQYPRWDTSSCHGGMRWQIWPYQDGYLTKNAISNGGLFQLSARLALYTGNKTYADWAERIWDWSATTPLLKEKNWNIADTTTCGTQCTDHGDYQWTYNYATYISGAAYMHNYTNGTETKWKDGVVGLIKTSQQFYPTTGFNGDGGQILCEITCEAGGNCDRNQITFKAYFANWLGMLTTIVPDTYDLIFPQLRTSAQAAAKQCSGGDDGVHCGIRWYKQAAWDGTKGLEQQMAVLGVLAANLIPFKNKAPLSLTSGGTSKSNPTAGTNTSDNDVPVLNTIGTGDRAGAGILTVIFVSGWAVAVTWMIRGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>W6QD20</accession>
    <name>W6QD20_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="10 14">6-phosphogluconate dehydrogenase, decarboxylating</fullName>
            <ecNumber evidence="10 14">1.1.1.44</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">GND1</name>
        <name evidence="16" type="ORF">PROQFM164_S03g001317</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10 14">
            <text>6-phospho-D-gluconate + NADP(+) = D-ribulose 5-phosphate + CO2 + NADPH</text>
            <dbReference type="Rhea" id="RHEA:10116"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58759"/>
            <dbReference type="EC" id="1.1.1.44"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10 14">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 3/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 10">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10 14">Belongs to the 6-phosphogluconate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.44" evidence="10 14"/>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QD20"/>
    <dbReference type="STRING" id="1365484.W6QD20"/>
    <dbReference type="OMA" id="CVTHVGP"/>
    <dbReference type="OrthoDB" id="434986at2759"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00410"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004616">
        <property type="term" value="F:phosphogluconate dehydrogenase (decarboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019521">
        <property type="term" value="P:D-gluconate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009051">
        <property type="term" value="P:pentose-phosphate shunt, oxidative branch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000002">
        <property type="entry name" value="6-phosphogluconate dehydrogenase, decarboxylating"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.320:FF:000002">
        <property type="entry name" value="6-phosphogluconate dehydrogenase, decarboxylating"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000007">
        <property type="entry name" value="6-phosphogluconate dehydrogenase, decarboxylating"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.320">
        <property type="entry name" value="6-Phosphogluconate Dehydrogenase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006114">
        <property type="entry name" value="6PGDH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006113">
        <property type="entry name" value="6PGDH_Gnd/GntZ"/>
    </dbReference>
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        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006184">
        <property type="entry name" value="6PGdom_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006183">
        <property type="entry name" value="Pgluconate_DH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00873">
        <property type="entry name" value="gnd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006765">
        <property type="entry name" value="PRK09287.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11811">
        <property type="entry name" value="6-PHOSPHOGLUCONATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00393">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000109">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00076">
        <property type="entry name" value="6PGDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01350">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00461">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14" id="KW-0311">Gluconate utilization</keyword>
    <keyword evidence="5 10 14" id="KW-0521">NADP</keyword>
    <keyword evidence="6 10 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8 10 14" id="KW-0570">Pentose shunt</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphogluconate dehydrogenase C-terminal" evidence="15">
        <location>
            <begin position="182"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="186"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="193"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="13"/>
            <end position="18"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="36"/>
            <end position="38"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="78"/>
            <end position="80"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="12">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="12">
        <location>
            <begin position="132"/>
            <end position="134"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="12">
        <location>
            <begin position="189"/>
            <end position="190"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="12">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="12">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="12">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="448"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="454"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR000109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000109-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000109-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000109-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CDM34593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="491" mass="53761" checksum="2D2447BE4BEE26D2" modified="2014-04-16" version="1">MADQAVADFGLIGLAVMGQNLILNVADHGFTVCAFNRTVSKVDHFLANEAKGKSIIGAHSIQEFCAKLKRPRRIMLLVMAGKPVDDFIEALLPFLEKGDIIIDGGNSHFPDSNRRTQYLNGKGISFVGSGVSGGEEGARYGPSLMPGGNEAAWPHIKDIFQSIAAKSDGEACCDWVGDEGSGHYVKMVHNGIEYGDMQLICEAYDILKRGVGLSSKEIGDVFAKWNSGVLDSFLVEITRDILYYNDNDGTPLVDKILDKAGQKGTGKWTAINALDLGMPVTLIGEAVFSRCLSALKDERGRASTILSGPTPKFEGDKQAFIDDLEQALYASKIISYAQGFMLIQNAAKEYKWKLNKPSIALMWRGGCIIRSVFLKDITKAYRSNPDLENLLFDDFFNKAINNAQTGWRHVISKTALWGIPAPAFSTALAFYDGYRSKNLPANLLQAQRDYFGAHTFRIKPEDASETFPEGKDIHVNWTGRGGDVSASTYIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W6QDD6</accession>
    <name>W6QDD6_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S03</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S03g001428</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QDD6"/>
    <dbReference type="STRING" id="1365484.W6QDD6"/>
    <dbReference type="OMA" id="KTTHDHT"/>
    <dbReference type="OrthoDB" id="3366546at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050656">
        <property type="entry name" value="PINX1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23149">
        <property type="entry name" value="G PATCH DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23149:SF33">
        <property type="entry name" value="PROTEIN TMA23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="11"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="115"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM34703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="266" mass="29344" checksum="92ECEFB6905376B5" modified="2014-04-16" version="1">MDAQAYLIKHGWSGPGNPLNPNKRPGAHSGLGLTRPLLVSRKTNNHGVGKKTTKDPTNQWWLRGFEDALKGVGNDSFEATSARENNALTSELYRHFVRGDGLAGTLEGKKDESASTSTSTSTSTSKSKRKRENEDEGERKAKKLAKAARKVEKAQRKEARRVKRAAKAERKEKKIAGKLAKKALKEKKRTASEEDYPTPRSIDQESDLTGAETTGTDEAITRLEEKAAKKEKKESKKTKSIGDNVGAEDSKKKSKKEKKDKKEAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>W6QDH4</accession>
    <name>W6QDH4_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Branched-chain-amino-acid aminotransferase</fullName>
            <ecNumber evidence="11">2.6.1.42</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PROQFM164_S01g001463</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-isoleucine + 2-oxoglutarate = (S)-3-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24801"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:35146"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:18321"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:17865"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-valine + 2-oxoglutarate = 3-methyl-2-oxobutanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24813"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.42" evidence="11"/>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QDH4"/>
    <dbReference type="STRING" id="1365484.W6QDH4"/>
    <dbReference type="OMA" id="GKEEHEW"/>
    <dbReference type="OrthoDB" id="1732691at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052656">
        <property type="term" value="F:L-isoleucine-2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052654">
        <property type="term" value="F:L-leucine-2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052655">
        <property type="term" value="F:L-valine-2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:L-leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01557">
        <property type="entry name" value="BCAT_beta_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.10.10:FF:000004">
        <property type="entry name" value="Branched-chain-amino-acid aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.10:FF:000012">
        <property type="entry name" value="Branched-chain-amino-acid aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="entry name" value="D-amino Acid Aminotransferase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018300">
        <property type="entry name" value="Aminotrans_IV_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005786">
        <property type="entry name" value="B_amino_transII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033939">
        <property type="entry name" value="BCAT_family"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11825:SF69">
        <property type="entry name" value="BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11825">
        <property type="entry name" value="SUBGROUP IIII AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006468">
        <property type="entry name" value="BCAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="D-aminoacid aminotransferase-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00770">
        <property type="entry name" value="AA_TRANSFER_CLASS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3 11 12" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="7 11" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="6 10" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11 12" id="KW-0808">Transferase</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="8">
        <location>
            <position position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR006468-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDM27652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="396" mass="43758" checksum="337FC140E4A5BF0D" modified="2014-04-16" version="1">MGSVAPNVAELDASNFNITRSTNLRDLPLPGSPEELSHSHCTDHMVTVKWTAAKGWETPEVKPYQNLSIPPTASVLHYATECFEGMKAYRGYDGKLRLFRPDCNGARLNTSSQRSSLPGFKYDEVKKLVAKLLQIDGPRWLPNPGSYLYIRPTVIGNGPHLGVQVPKEALLFIIAVPWPDMTKMKKDPQAETPKGLRLYASSPDTIRAWPGGFGYAKLGANYGPSLQAHGKAQALGYDQILWLFGPDRQVTEAGASNFFIVWHNTEGKLELVTAPLDNQLILPGITRRSVLELVRERLSQNFVGKLAPLEAVERTLTIDDIEKASKEGRIVEAFVSGTAYFITPVALIHNEDTDINTLGANGEPAGYAAQIKSWLEAIMFGKEEHEWAYTIENEGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W6QET1</accession>
    <name>W6QET1_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Nucleotide-binding, alpha-beta plait</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PROQFM164_S03g001702</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QET1"/>
    <dbReference type="STRING" id="1365484.W6QET1"/>
    <dbReference type="OMA" id="NLYMLFA"/>
    <dbReference type="OrthoDB" id="277802at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097157">
        <property type="term" value="F:pre-mRNA intronic binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030626">
        <property type="term" value="F:U12 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12246">
        <property type="entry name" value="RRM1_U1A_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000572">
        <property type="entry name" value="U1 small nuclear ribonucleoprotein A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
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        <location>
            <begin position="24"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="132"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="164"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDM34975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="188" mass="20295" checksum="7BA659C6B56AD772" modified="2014-04-16" version="1">MASKSQPARGGADSKAVATGAPNQTLYCTNLPDRRIQKQDLRTALYALFSTYGTVLDVVCMKTNKMRGQAHIVFRDVQASTQALRALQGFDFFGKQMKIVYGKGSSNVISKLRGTYVAPVETAPAPVTTDLQKSIFGAPPGALPPRPTTDTNGEGHGVKRPREEESDNEEAPMDEDSDVPMDASSDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
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        </submittedName>
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    </gene>
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        </lineage>
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    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1">FM164</strain>
        </source>
    </reference>
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    <dbReference type="OMA" id="RFKITCH"/>
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    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM32714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="68" mass="7931" checksum="EEB10912C6F89EB1" modified="2014-04-16" version="1">MRRNDLTDRPPLLFGEVFSRARKDRFKITCHCDVSDKDTLRNIHQVIHHIGETGADRVDHSLDAVYEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W6QEY8</accession>
    <name>W6QEY8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Genomic scaffold, ProqFM164S03</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PROQFM164_S03g001345</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
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                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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            <location evidence="2">Centromere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CENP-K/MCM22 family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000070">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020993">
        <property type="entry name" value="Centromere_CenpK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14401">
        <property type="entry name" value="CENTROMERE PROTEIN K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14401:SF6">
        <property type="entry name" value="CENTROMERE PROTEIN K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0137">Centromere</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="248"/>
            <end position="268"/>
        </location>
    </feature>
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        <location>
            <begin position="4"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
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            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="257"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005795"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDM34621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="347" mass="39258" checksum="9DAF3D2E2FE65676" modified="2014-04-16" version="1">MDIADQTVQKIQKFAQRRQEAEHEAAKEPLSETALHVYTRRLDATLQGLQEQVKRQQDELNKACYLRELSSLDLTETGTDSWARISQARRARKAYDSLLKSDDELPATDSVLPSLIAIEETARLVQENKVSVTMTAEQLSVDRERLRVEEANLRDSQSIASGLRERIQRIRNANTRKEEQTPSQVAREQLTLQKEQNKELDRTSANLKVSLDTFIDETLAPMLAAEDLGGPTVGDAFEVSDATLKAGYTAHGKPKKQKEPTETEDGSQRRIDKFMKRNADEAPTNKREAVAKEMHGLLDAMLEANTYIDLERDSASSRFLVRAKVAQFHPRDARRLRLIDFGRSLGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W6QF14</accession>
    <name>W6QF14_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S04</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S04g000214</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QF14"/>
    <dbReference type="STRING" id="1365484.W6QF14"/>
    <dbReference type="OrthoDB" id="2103397at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM35333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="100" mass="11617" checksum="B10210864ACFF7CF" modified="2014-04-16" version="1">MPRSFFEYLLSGVVDYSIWFGSPGNYETNLVMVEAKKTRSLDEGMLSFLGYMGMIHHARKTAKMQDTPVYGIVTDSFRWDFIQIRADSEVQNPWDILECH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>W6QFB1</accession>
    <name>W6QFB1_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type DNA-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PROQFM164_S04g000354</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QFB1"/>
    <dbReference type="STRING" id="1365484.W6QFB1"/>
    <dbReference type="OMA" id="PKQACDN"/>
    <dbReference type="OrthoDB" id="4132249at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050797">
        <property type="entry name" value="Carb_Metab_Trans_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668:SF19">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="11"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM35473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="606" mass="67131" checksum="A458D0DA90E1C86F" modified="2014-04-16" version="1">MSSKQPKPKQACDNCRRRKIKCSRELPCDKCKRLLLSCSYSDVLRRKGPKFRTLYPLAPIHPLSSRQDPPEHIYPEDAGTGEIPDYQFNSPISPEFGIADSQFAGQDFSDTFSHLPPPELVSSPGSTDSTVESAIGYGYNYARPADRRLSPQILLVHVNIYLKYLFPIMPVIRGDQLRLDCHRPGQLSTQRYALLVSLCAATHIQLKLDGATHIPDPARLQSFGGGHSLMSGEELLAEAVRARRDCDLLEALSTESLLTSFFLFASYGNLDRQDQAWFFLCQATSFAFTLGLHRESTYAEYGVEEAEERRRVFWLLFITERGYALQQAKPVMLRSSIHKPQVLCSEDPILAYGFINLINIFENLTPNLYDWISAGGGDGILERPPISAIQSSLCKAISLEGVLEVQQVDILITQQWLQTMMWKLSMSHATQPGSHDDAVLPFHLPVMVSKSMMSVIGAASQGAVDAHGIGMEQKLFDLGSSVADVTRSLGPKAVHRLAESTIDPNELLWGILHTLSQIRGSPSYLFPILLDRCRTVLGLDCNITTGNFLPILGAAVPDQLASWSGQNVWDYATSAEDIEIHDVDGQAESALPHVPQELGFEDCLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>W6QFB3</accession>
    <name>W6QFB3_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="14 15">mRNA cap guanine-N(7) methyltransferase</fullName>
            <ecNumber evidence="3 15">2.1.1.56</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11 15">mRNA (guanine-N(7))-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12 15">mRNA cap methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">abd1</name>
        <name evidence="19" type="ORF">PROQFM164_S04g000071</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Responsible for methylating the 5'-cap structure of mRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a 5'-end (5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:67008"/>
            <dbReference type="Rhea" id="RHEA-COMP:17166"/>
            <dbReference type="Rhea" id="RHEA-COMP:17167"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:156461"/>
            <dbReference type="ChEBI" id="CHEBI:167617"/>
            <dbReference type="EC" id="2.1.1.56"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 15">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the class I-like SAM-binding methyltransferase superfamily. mRNA cap 0 methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.56" evidence="3 15"/>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QFB3"/>
    <dbReference type="STRING" id="1365484.W6QFB3"/>
    <dbReference type="OMA" id="KPFLEVW"/>
    <dbReference type="OrthoDB" id="10248867at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004482">
        <property type="term" value="F:mRNA 5'-cap (guanine-N7-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000231">
        <property type="entry name" value="mRNA cap guanine-N7 methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004971">
        <property type="entry name" value="mRNA_G-N7_MeTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016899">
        <property type="entry name" value="mRNA_G-N7_MeTrfase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039753">
        <property type="entry name" value="RG7MT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12189:SF2">
        <property type="entry name" value="MRNA CAP GUANINE-N7 METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12189">
        <property type="entry name" value="MRNA GUANINE-7- METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03291">
        <property type="entry name" value="mRNA_G-N7_MeTrfase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028762">
        <property type="entry name" value="ABD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51562">
        <property type="entry name" value="RNA_CAP0_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 15 19" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9 15 16" id="KW-0506">mRNA capping</keyword>
    <keyword evidence="5 15" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="10 15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 15" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7 15" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 15 19" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MRNA cap 0 methyltransferase" evidence="18">
        <location>
            <begin position="182"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="18"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="17">
        <location>
            <begin position="57"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="129"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="191"/>
            <end position="192"/>
        </location>
        <ligand>
            <name>mRNA</name>
            <dbReference type="ChEBI" id="CHEBI:33699"/>
        </ligand>
        <ligandPart>
            <name>mRNA cap</name>
        </ligandPart>
    </feature>
    <feature type="site" description="mRNA cap binding" evidence="16">
        <location>
            <position position="242"/>
        </location>
    </feature>
    <feature type="site" description="mRNA cap binding" evidence="16">
        <location>
            <position position="248"/>
        </location>
    </feature>
    <feature type="site" description="mRNA cap binding" evidence="16">
        <location>
            <position position="275"/>
        </location>
    </feature>
    <feature type="site" description="mRNA cap binding" evidence="16">
        <location>
            <position position="350"/>
        </location>
    </feature>
    <feature type="site" description="mRNA cap binding" evidence="16">
        <location>
            <position position="464"/>
        </location>
    </feature>
    <feature type="site" description="mRNA cap binding" evidence="16">
        <location>
            <position position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00033387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR028762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR028762-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CDM35190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="540" mass="61162" checksum="F141970D15C3905C" modified="2014-04-16" version="1">MDHPNGDRARDAARGRSTPRSPARTNTTYPSTDTGRHRSIEGDTAADGSNHVSSAASKRKRLQERHQALRKRGRTPPSVFSRRNRSRSPGGAPPREDRRSRSPLQPRRSPSPDAPRQRKRPGGGARQGLLDRETLRRKQEERERAEVDEAMRNSQQRGISDVVRQHYNAVPERGREWRKTESKIKGLRSFNNWVKSTLIQKFSPDETFVARFEDSKDWANDSQGPPPVDNQKLLVLDLGCGKGGDLGKWQLAPQPVDLYVGLDPANVSIEQARGRYDQMRSGRGQRGRRPPQPIFHAEFYPKDCFGEWLGDIDIIQRVGIDANAGPGGSIMASRYGGGGFDIVACMFAIHYAFESEEKTRQMLSNVAGCLKKGGRFLGVCPNSDVITSRVSAFHKARKEREAAKPVEPEGPEDGEVEEDERAQWGNDIYRVQFPGATPEDGIFRPPFGWKYSYFMKEAVEEVPEYVVPWEAFRALTEDYNLELQYRKPFLDIWEDEKNHPELGPLGDRMGVRDRATGALNMTEEEKEAVSFYHAYCFYKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W6QFM8</accession>
    <name>W6QFM8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S02g003135</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QFM8"/>
    <dbReference type="STRING" id="1365484.W6QFM8"/>
    <dbReference type="OrthoDB" id="4227485at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM32984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="324" mass="37352" checksum="D921B8FC6BA1781E" modified="2014-04-16" version="1">MFHYRYKPKQLRSRNLGQHIAQGFFESLSREEFYKYKERKQRRNIFYNQIFGPNQPPSEYITSLGVVKDIIRSFFGKSSFFQPILDKRQASPIQSLIRLTKTALGSINTNIDFEEWHLQVQPVNPSPSEAPQPSINSGPELVEEDTSKPIELANHPSGTPDHDAPPLAASFEETSQPIETKNYLSVRNKVPKILSTWYQSHQEVIVLYLFESQVYYKFFLGDGFNLRAVLQDLASNHLFIVINEYGIGTPDMNKVYKAALKERLILIRKIDNPSHGNDMEGTISLDKLRDYVLDYDIHTGKRKADFTDIRSGKRHQDTAPDKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W6QFU4</accession>
    <name>W6QFU4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BTB/POZ fold</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S04g000574</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QFU4"/>
    <dbReference type="STRING" id="1365484.W6QFU4"/>
    <dbReference type="OMA" id="NWISENA"/>
    <dbReference type="OrthoDB" id="6359816at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843:SF5">
        <property type="entry name" value="BTB_POZ DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="20"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM35693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="223" mass="25226" checksum="9B74EED1501156EA" modified="2014-04-16" version="1">MGFPDLQPILQSLLDSGRYSDLAISCEGQKFQVHRAIVCSQSPFFDAAVKGGFREASLSHVDLPDDELATIQRVVSFLYHQDYEDTDGSYFQNRKCASGNGMEPHAAMWNNLGVFMAADKFDISRLKILARSQIMNWISENARGFPLIVQQIWITIPPLESEIRDAIIKSISCDAQEFLAYDESMVIMTDIPDITIAVLKKIAEENSSLKRKLQRQRKTASMW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>W6QGH9</accession>
    <name>W6QGH9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Zn(2)-C6 fungal-type DNA-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PROQFM164_S04g000809</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QGH9"/>
    <dbReference type="OMA" id="PDDALMW"/>
    <dbReference type="OrthoDB" id="103819at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF1">
        <property type="entry name" value="MISCELLANEOUS ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="522"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="18"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="86"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM35928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="678" mass="77078" checksum="173546B2E52F9ED3" modified="2014-04-16" version="1">MCSHSNFSHQMNYDALRACDLCFSRKVRCDKQLHCANCTDAGVECSRTRARRPRRQSPSVISALGERLLTLERTVSEGIENRIPSNVTDHYDGNMPSKKRRLEHASPIEGTPQPTQNECAIGSATHLAEKARIVIQGELDGNECMDRERKAILRSALQFVDVTGQRRSSITDKFSPLEVSHEDFHDGPFIAPSPELLYMLLPEPTATIGRSSSVQWPDHISDKTLEKMASTILSDNDLEHGQEFYQYCICVYVKAIFHLFQKPRAYMDPRINAQFLKSKKLYETYAFRALKRLNFLNAPTLPLIQSLISAAFFMQYLGNMSQSWIFNSYAARLITALGYHEIRNPPGMSNLNEDIYSAVCWCFYLDRTLSTLLYRPLSLPEPCISPANLISADQNLPHIPLIRILFDLAQVQGELLNCGNADNTRQIIANHSRLQERMEVIYSRLQSSRVTAPDCISADWISGEFCYYAILVDILRSRLKCAFSPLTHKECVSYSRKSLRALHHLQKNLADVPGFVDPYPSFLTWTVLLYPFSPFFVLFCNIIGELDMDDYNLMQEITQSLSQFAASPYISKLLKLLYYLQNLCVPLIQAKQRMGPQVKVPTLYPSMAGTWHVGDPASDEHSHLLMSSSPYVDPVAETNLQQLQTTSDGSYAPDDALMWQLFNSQISLEWFESNPFSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>W6QGI1</accession>
    <name>W6QGI1_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Monothiol glutaredoxin-4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">grx4</name>
        <name evidence="9" type="ORF">PROQFM164_S02g003421</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Monothiol glutaredoxin involved in the biogenesis of iron-sulfur clusters. Binds one iron-sulfur cluster per dimer. The iron-sulfur cluster is bound between subunits, and is complexed by a bound glutathione and a cysteine residue from each subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutaredoxin family. Monothiol subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM33269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QGI1"/>
    <dbReference type="STRING" id="1365484.W6QGI1"/>
    <dbReference type="OMA" id="WAEPCKT"/>
    <dbReference type="OrthoDB" id="415696at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015036">
        <property type="term" value="F:disulfide oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03028">
        <property type="entry name" value="GRX_PICOT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02984">
        <property type="entry name" value="TRX_PICOT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000012">
        <property type="entry name" value="Monothiol glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000092">
        <property type="entry name" value="Monothiol glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033658">
        <property type="entry name" value="GRX_PICOT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004480">
        <property type="entry name" value="Monothiol_GRX-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10293">
        <property type="entry name" value="GLUTAREDOXIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10293:SF73">
        <property type="entry name" value="GLUTAREDOXIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="7">
        <location>
            <begin position="7"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="Glutaredoxin" evidence="8">
        <location>
            <begin position="197"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="147"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00055846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM33269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="290" mass="30714" checksum="395869C78CCA40BA" modified="2014-04-16" version="1">MSTLIEITSEADFSSHLSSLSPSALVVLYFHTPWAAPCAQMGAVLSALASQYPATTPPTISFVSINAEELPDISEEYDVSAVPFVVCLRSGQILESISGSDAVKVRDAVERHAGRGNVAGAVGPMDGVKANIPPPLSAVAREDGPFTATQSPVTAAEPPSADAANATAVASAPTLTPEQSREALFARLEQLVNAASVMLFMKGTPSSPQCGFSRQLVGILRERSVKYGFFNILADEDVRQGLKEYAEWPTFPQLWVNGELVGGLDIVREEINSDPDFLNDHSVNKPTAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W6QGQ7</accession>
    <name>W6QGQ7_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">D-xylose reductase [NAD(P)H]</fullName>
            <ecNumber evidence="2">1.1.1.307</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">yvgN</name>
        <name evidence="11" type="ORF">PROQFM164_S03g000093</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the initial reaction in the xylose utilization pathway by reducing D-xylose into xylitol. Xylose is a major component of hemicelluloses such as xylan. Most fungi utilize D-xylose via three enzymatic reactions, xylose reductase (XR), xylitol dehydrogenase (XDH), and xylulokinase, to form xylulose 5-phosphate, which enters pentose phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>xylitol + NAD(+) = D-xylose + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27441"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17151"/>
            <dbReference type="ChEBI" id="CHEBI:53455"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.307"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>xylitol + NADP(+) = D-xylose + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27445"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17151"/>
            <dbReference type="ChEBI" id="CHEBI:53455"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.307"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.307" evidence="2"/>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QGQ7"/>
    <dbReference type="STRING" id="1365484.W6QGQ7"/>
    <dbReference type="OMA" id="FMTMKAA"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19071">
        <property type="entry name" value="AKR_AKR1-5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000015">
        <property type="entry name" value="Oxidoreductase, aldo/keto reductase family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="2,5-DIKETO-D-GLUCONIC ACID REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827:SF13">
        <property type="entry name" value="ALDO_KETO REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00063">
        <property type="entry name" value="ALDOKETO_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="10">
        <location>
            <begin position="31"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="9">
        <location>
            <position position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDM33369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="282" mass="31441" checksum="C47BF9708B9719D6" modified="2014-04-16" version="1">MAPISLQSTYKLVSGYEIPVVGFGVYQTPSDVTEKVTRKAIEIGYRHVDCAKVYGNELESAAAIRGSGVDRSKIFYTSKVPSKCMGYEKAKKAIEESIAAANLGYIDLMLVHAPYGGKEDRLGTWRALVEAQKAGHVRSLGVSNFAIQHLEELEEYIKSGAGGQITVGQYEIHPWCPREDIAEWLQKRNIIVEAYSPLVQATRMKEPVLQNLAKKHGKSEAQILVRWSLQKGYVPLPKSVTESRILENSQVFDFTLSDEDMASLKLNSYAPVCWDPVRDCKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W6QGV1</accession>
    <name>W6QGV1_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NAD-dependent deacetylase, sirtuin family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PROQFM164_S04g000546</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sirtuin family. Class I subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QGV1"/>
    <dbReference type="STRING" id="1365484.W6QGV1"/>
    <dbReference type="OMA" id="RRHYWAR"/>
    <dbReference type="OrthoDB" id="424302at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017136">
        <property type="term" value="F:histone deacetylase activity, NAD-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="entry name" value="SIR2/SIRT2 'Small Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050134">
        <property type="entry name" value="NAD-dep_sirtuin_deacylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085:SF10">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="5">
        <location>
            <begin position="42"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="162"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDM35665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="379" mass="41115" checksum="581C384A2E0321E0" modified="2014-04-16" version="1">MTTPAIRIPFTGPLPPAIITPRAATTLAGAIDAINTFFTAPPSLNLRGVDVGRHSQTVLLTGAGISVASGLSDYRGDQGTYRRNKSYRPIYYHEFISHHESRKRYWARSFVGWPGLLKAKPNSTHWAIKGLGEKGYISSVVTQNVDSFHSLAHPELSTLELHGYLRSVVCVSCQNQLPRADFQASLEKLNPAWAEFLARMVAEGALDTDNPEEQRRKGLKLNPDGDVDLAEAPYSTFRYPPCPTCLENPPTLRDGTKAIVEVESDGALSATSNAGILKPAVIMFGENIDPLVKTAAEEAIDDAGRLLILGSSLATFSAWRLVERAHKRGMPIGIVNVGGVRNEALLFGNLGHEPTPHVRCSHPCQSVLPTVVSQLPANL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>W6QH68</accession>
    <name>W6QH68_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Elongation factor 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">tef3</name>
        <name evidence="18" type="ORF">PROQFM164_S04g000636</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein biosynthesis; polypeptide chain elongation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ABC transporter superfamily. ABCF family. EF3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QH68"/>
    <dbReference type="STRING" id="1365484.W6QH68"/>
    <dbReference type="OMA" id="VLSEAMW"/>
    <dbReference type="OrthoDB" id="2110130at2759"/>
    <dbReference type="UniPathway" id="UPA00345"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03221">
        <property type="entry name" value="ABCF_EF-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000076">
        <property type="entry name" value="Elongation factor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.990:FF:000001">
        <property type="entry name" value="Elongation factor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000193">
        <property type="entry name" value="Probable Elongation factor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1390.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050611">
        <property type="entry name" value="ABCF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047038">
        <property type="entry name" value="eEF3_chromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040533">
        <property type="entry name" value="EF3_4HB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047036">
        <property type="entry name" value="EF3_4HB_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211:SF5">
        <property type="entry name" value="ELONGATION FACTOR 3A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17947">
        <property type="entry name" value="4HB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24984">
        <property type="entry name" value="HEAT_EF3_GNC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24987">
        <property type="entry name" value="HEAT_EF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 18" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0694">RNA-binding</keyword>
    <feature type="repeat" description="HEAT" evidence="15">
        <location>
            <begin position="187"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="17">
        <location>
            <begin position="446"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="17">
        <location>
            <begin position="690"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1000"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1041"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="1043"/>
            <end position="1054"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CDM35755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="1066" mass="117471" checksum="543475D000AD8B06" modified="2014-04-16" version="1">MPAASDATPAATGKASAQSVAVLEDLIKNLNISTSADETNAAATNLATLFSGPIAEQTLPLKATEIFKKQLANKKDATARERACEGIRAIAAHPTIAPGVEPHLVALLGPVLAAVGDKVVAVKQAAQSTAIAIVQAVSGNAVKAVITPILYSLANAQKWPEKMAALDCINILVESAQMQLGYQVPTLIPVISEAMWDTKAEIKKAAYSTMEKVCGLIVNKDIERFIPELIKCIAKPENVAETVHLLGATTFVTDVTGPTLAIMVPLLDRGLVERETAIKRKTAVIVDNMCKLVEDPQLVAPFLPKMLPGLNKNFETLADPEAREKTRQALDTLSRVGNVVDGKIPEVSRAGDISTIVAILKEILEAKHKDVIAHSEEAITYVAAIAAQLVDEKENDHVIWTQNTMPYITAIVGEENAKSIAEELRKKACPDAAAADAIASDEEEGVDLCNCTFSLAYGAKILLNQTHLRLKRGQRYGLLGPNGSGKTTLMRAINNEQLEGFPKKDEVKTVYVEHDLDSADTEQTVIAWTQKKLAEVGQNPPREELEGKLLNEFGFSEFQIQGPITALSGGWKMKLALCRAVFENPDILLLDEPTNHLDVKNVAWLEEYLKNSPCTSIMVSHDSKFLDNVIQHVVHYERFKLRRYRGTLSEFVKQHPAARSYYELGASEMEFKFPEPGFLEGVKTKSKAICRVSNMSFQYPGTPKPQIHGITFQVSLGSRIAVIGANGAGKSTLVNVLTGELIPTSGEVYQHENIRIAYIKQHAFAHIDNHLNSTPSEYIQWRFQTGEDRETMDRANKIVTEEDEKAMDKIYKIEGTLRRVIGIHSRRKFKNTYEYEISWSLGDNVGMKSEKWTPLMSADNTWLPRSEIIVSHPKQVAEVDQKEALASGQFRPLVRKEIEQHCANFGLDAELVSHSRMRGLSGGQRVKVVLAACSWQRPHLIVLDEPTNYLDRDSLGALSKAIKSFEGGVVIITHSREFTEHLTEEVWAVNDGVMTPSGHNWVQGQGSGPRLDAKGDDDEDKFDAMGNKIVVTKKVKLTGSELRKKKKDRAARRKRGEEVFSDEDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>W6QHD1</accession>
    <name>W6QHD1_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="9">JAB1/Mov34/MPN/PAD-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PROQFM164_S03g000328</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1365484.W6QHD1"/>
    <dbReference type="OMA" id="ANKWNTS"/>
    <dbReference type="OrthoDB" id="1931567at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097157">
        <property type="term" value="F:pre-mRNA intronic binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030619">
        <property type="term" value="F:U1 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030620">
        <property type="term" value="F:U2 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030623">
        <property type="term" value="F:U5 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017070">
        <property type="term" value="F:U6 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016539">
        <property type="term" value="P:intein-mediated protein splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000393">
        <property type="term" value="P:spliceosomal conformational changes to generate catalytic conformation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000244">
        <property type="term" value="P:spliceosomal tri-snRNP complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08056">
        <property type="entry name" value="MPN_PRP8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13838">
        <property type="entry name" value="RNase_H_like_Prp8_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.80.40:FF:000001">
        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.230:FF:000001">
        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.43.40:FF:000001">
        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000002">
        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1570.40:FF:000001">
        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1570.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.16.10">
        <property type="entry name" value="Hedgehog/Intein (Hint) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.40">
        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8, U5-snRNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036844">
        <property type="entry name" value="Hint_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006141">
        <property type="entry name" value="Intein_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012591">
        <property type="entry name" value="PRO8NT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012592">
        <property type="entry name" value="PROCN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012984">
        <property type="entry name" value="PROCT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027652">
        <property type="entry name" value="PRP8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021983">
        <property type="entry name" value="PRP8_domainIV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043173">
        <property type="entry name" value="Prp8_domainIV_fingers"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043172">
        <property type="entry name" value="Prp8_domainIV_palm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019581">
        <property type="entry name" value="Prp8_U5-snRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042516">
        <property type="entry name" value="Prp8_U5-snRNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019580">
        <property type="entry name" value="Prp8_U6-snRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019582">
        <property type="entry name" value="RRM_spliceosomal_PrP8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11140">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR PRP8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11140:SF0">
        <property type="entry name" value="PRE-MRNA-PROCESSING-SPLICING FACTOR 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08082">
        <property type="entry name" value="PRO8NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08083">
        <property type="entry name" value="PROCN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08084">
        <property type="entry name" value="PROCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12134">
        <property type="entry name" value="PRP8_domainIV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10598">
        <property type="entry name" value="RRM_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10597">
        <property type="entry name" value="U5_2-snRNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10596">
        <property type="entry name" value="U6-snRNA_bdg"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51294">
        <property type="entry name" value="Hedgehog/intein (Hint) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50817">
        <property type="entry name" value="INTEIN_N_TER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="JAB1/MPN/MOV34 metalloenzyme" evidence="8">
        <location>
            <begin position="2275"/>
            <end position="2409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM33604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="2511" mass="291215" checksum="50A8DE3510B5F3BC" modified="2014-04-16" version="1">MASLPPPPPPPGWSAAPPMPMAPPPPGYQPPADPNVAKFAQKKNEWLRTQRNRFGEKRKAGFVETQKADMPPEHLRKIVRDIGDVSQKKFTNEKRSYLGALKFMPHAVLKLLENMPMPWESAREVKVLYHVNGCLTLVNETPRVIEPVFHAQWATMWMCMRREKSDRRHFKRMRFPPFDDEEPPLSWSENIEDVEPLEPIQMELDEVEDAAVYEWFYDHRPLLDTPHVNGPSYKKWNLSLPQMATLHRLSHQILSDVVDQNYYHMFDLNSFFTAKALNVAIPGGPRFEPLYKDIDPNDEDFSEFNAIDRIIFRAPIRTEYRVTFPFLYNTLPRSVKVAWYSHPQVVYVRTEDPNLPAFYFDPVINPISSRSVAPKNITVSHEDEIFGPGNNEDDEFELPGDVEPFFNDEELYTSETASAIALWWAPHPFDKRSGKMVRAQDVPLVKQWYLEHCPQGQPVKVRVSYQKMLKTYVLNELHKGTPKAQSKQNLMKTLKTTKFFQQTSIDWVEAGLQVCRQGFNMLNLLIHRKNLTYLHLDYNFNLKPVKTLTTKERKKSRFGNAFHLMREILRLTKLIVDAQVQYRLGNIDAFQLADGILYAFNHVGQLTGMYRYKYKLMHQIRSCKDLKHLIYYRFNSGPVGKGPGCGFWAPAWRVWLFFMRGIIPLLERWLGNLLSRQFEGRHSKGVAKTVTKQRVESHFDLELRASVMADLMDMMPEGIKQNKVNVVLQHLSEAWRCWKSNIPWKVPGLPAPIENIILRYVKSKADWWISVAHYNRERIRRGATVDKTVAKKNLGRLTRLWLKSEQERQHNYLKDGPYVSSEEAVAIYTTMVHWLESRKFSPIPFPSVSYKHDTKILILALERLRESYSVKGRLNQTQREELALIEQAYDSPGTTLARIKRFLLTQRAFKEVKIDMNDNYNNINPVYDIEPIEKITDAYLDQYLWYQAEQRHLFPAWIKPSDSEVPPLLTYKWTQGINNLSNVWETAEGETNVMIETELSKVYEKIDITLLNRLLRLIMDHNLADYITSKNNVQLSYKDMNHTNSYGLIRGLQFSGFVFQYYGLMIDLLLLGLQRASEMAGPPGSPNDFLQFRDRATETRHPIRLYTRYVDKIWVFFRFQADDSRDLIQRFLTENPDPNFENVIGYKNKKCWPRDCRMRLMRHDVNLGRAVFWDMKNRLPRSITTIDWDDTFASVYSKDNPNLLFSMNGFEVRILPKMRNMNEEFSVKDSVWSLVDNSTKERTAHAFLQVTEEDVQKFNNRIRQILMSSGSTTFTKIANKWNTALIALFTYYREAAVSTVNLLDTIVKCETKIQTRVKIGLNSKMPSRFPPAVFYTPKELGGLGMISGSHILIPTSDKRWSKQTDTGITHFRAGMSHDEETLIPNIFRYIIPWEAEFIDSQRVWMEYSQKRMEAQQQNRRLTLEDLEDSWDRGLPRINTLFQKDRSTLSFDKGFRLRAEFKQYQLMKSNPFWWTSQRHDGKLWNLNAYRTDVIQALGGVETILEHTLFKATAFPSWEGLFWEKACLAKGTRLLRYDGTEINVEDVREGDQLLGPDGEPRRAFNIVNGIDRLYRVKIGGEKEDLVVTPNHILVLHREGASNGPKKQTVEITAAEFAALPTEERNMYSAFTSPRVEQSAESSSPQIHSFKIEHISLESEKTEWAGFRVDKDQLYLRHDYLVLHNSGFEESMKFKKLTNAQRSGLNQIPNRRFTLWWSPTINRANVYVGFQVQLDLTGIFLHGKIPTLKISLIQIFRAHLWQKIHESVVMDLCQVLDQELEQLGIEAVQKETIHPRKSYKMNSSCADILLFATNKWNVTRPSLVFDTKDVYEPTTTNKFWIDVQLRYGDYDSHDIERYVRAKYLDYTTDSMSIYPSATGLMIGVDLAYNLFSAYGQYFPGLKTLVQQAMAKIMKANPALYVLRERIRKGLQLYASESSQEFLNSQNYSELFSPQIQLFIDDTNVYRVTIHKTFEGNLTTKPINGAIFIFNPRTGQLFLKIIHTSVWAGQKRLGQLAKWKTAEEVAALIRSLPVEEQPKQLIVTRKGLLDPLEVHLLDFPNISIRASELQLPFQAAMKVEKLADMILRATEPQMVLFNLYDEWLKSISPYTAFSRLILILRALHVNIDKAKIILRPDKTVITQEHHIWPSLSDEDWIKVEVQLRDLILNDYGKKNNVNVQSLTSSEVRDIILGMEISAPSLQRQQAAEIEKQQEEQKQLTAVTTKTQNARGEDIIVTTTSQYEQQSFASKTEWRTRAIATSNLRTRSNNIYVSSDDIRDDGYTYIMPKNVLKRFITIADLRVQVTGYIYGSSPPDNDQVKEVRTIVMIPQVGNTRDVQLPHQLPQHDYLQNLEPLGIIHTVSGNEPPYMSAADVTHHARLMNAHPSWDKRTVTMTVSFTPGSVSLAAWGLTPAGYKWGAENKDTTSDQPQGFSTNMGEKCQLLLSDKIRGYFLVPEDNVWNYSFMGSSFGSVEKRPIYVKIDTPLKFYDDQHRPLHFQNFAELEDIWVDRADNFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W6QHV7</accession>
    <name>W6QHV7_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Basic-leucine zipper domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S03g000473</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QHV7"/>
    <dbReference type="STRING" id="1365484.W6QHV7"/>
    <dbReference type="OMA" id="PQSWHPY"/>
    <dbReference type="OrthoDB" id="2247093at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="2">
        <location>
            <begin position="305"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="261"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="374"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="84"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="303"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="377"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="416"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="433"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM33749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="483" mass="52194" checksum="68C3C48DF4444722" modified="2014-04-16" version="1">MSQDSRRAGSLSRDVTQTDDRGSDNDRTFNRNPTRRPPQRPRPQSWHPYGPVEPPLESMSSRPIGVHAILNHPQATTDLAGREPLSLPGPSSSPRPQGTSPIIRSGYALTSQPLSPYSRPLMNPASPSARFVGGGGRASGQSSVAQSPLLPHEPLMGPRLPVTSSPLPMETGLRSIAPLTSTQPPSLHSTSMHSRRISAGPGPLSNLKSQETSPITSHSTFNHFGHASPAVTSVSLAQSTASYPTAPQYMTLDPVVRTVSATKGPRRQPEQHPTRAGTPQDSSLPLGMIPCVLDMRSGSSSQAEKRKANSDASRRFRNRKRNEMQLEQRLTAQQDEIQRNIETVRRQSEEIRFLVQQRDHYRSERDFYRDQLGRTMSLSALPPRPSSPRSAQPTLLPASEPGTTTSWSGVDAARSASGTQPTSNPPQGRMLESVQSQPTWPASPPYSSTPIASAGRAVAGPHSRSPSLSGGQLPPLQGSWSRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W6QII9</accession>
    <name>W6QII9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase, DXD sugar-binding motif</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S04g000692</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 32 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QII9"/>
    <dbReference type="STRING" id="1365484.W6QII9"/>
    <dbReference type="OMA" id="TQNTHPD"/>
    <dbReference type="OrthoDB" id="409543at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000136">
        <property type="term" value="C:mannan polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000009">
        <property type="term" value="F:alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007577">
        <property type="entry name" value="GlycoTrfase_DXD_sugar-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039367">
        <property type="entry name" value="Och1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31834">
        <property type="entry name" value="INITIATION-SPECIFIC ALPHA-1,6-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31834:SF9">
        <property type="entry name" value="INITIATION-SPECIFIC ALPHA-1,6-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04488">
        <property type="entry name" value="Gly_transf_sug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM35811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="419" mass="48057" checksum="D62B4365AD9214F4" modified="2014-04-16" version="1">MSLRRIKVQASRYFTRRGSCILFVILIWFLFYHLPAPPSTQNNTRADRPPPEHRVEDTARFIYRSPFRNDPNVQYEQQLSNALEEIEKAVLTQSEESNISKDRIWQIAKSQKDRGEDSIVFKGKNKDWIYTLVTDKKAVEFLTNELSAIPEIATIYKSYPQNILRADLLRYLLLWYYGGFYADIDVFPARSIKACPALEPFFALTPDGYTKSTHPDISLVVGIEVDEPYASPKFMRDWHWTRSYGLIQYTMYAPRRFSPLLRETIVRVLAHTRQYNGEHTSFFPSLAYDEKTILGVTGPDVFTDAILDTLSSSLPSTHPFIQKSVDADADIGDLISAETGELEKRVTWAPFHRLRDPVCIQAGEAVPNESMGGLCVLPISVWGNGQRHSEAGGFNHPDACVNHRFGRTWKKGWWEYIFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W6QIK8</accession>
    <name>W6QIK8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta hydrolase fold-3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S04g000712</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QIK8"/>
    <dbReference type="STRING" id="1365484.W6QIK8"/>
    <dbReference type="OMA" id="NLCVRGN"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF8">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="99"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM35831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="338" mass="37155" checksum="29B6D77A37A6FC2B" modified="2014-04-16" version="1">MTAGITEPPYPLHESVKDLLHPEYVAFYNEHVINNQQVHLRPVEASRTSGVLIPGAGPMLEVGKTQDITVQRRATEGPPVPIRCFTPKGEAPPGGWPVMLYFHGGGWVLGNIDTENVVCSNLCVRGNCVVITVDYRLAPENRWPAAVHDCWEVFLWLIADGPAALPVDVSKLATGGSSAGGNLAAIITHKALTLSPPVHFLAQLLSVPVTDNTATVENNESYRRYEWTPALPALKMYWYRDHYVPNDADRTHPESSPLFWDGDYSQLPPALVMVGELDVLRSEGEQYAEKLQKAGVPVDLQVMPGMPHPFLAMDGALSEGKRCITLMCDALQKAFWGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W6QJ65</accession>
    <name>W6QJ65_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S03</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S03g000963</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QJ65"/>
    <dbReference type="STRING" id="1365484.W6QJ65"/>
    <dbReference type="OMA" id="YRRICEN"/>
    <dbReference type="OrthoDB" id="4358152at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM34239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="384" mass="44494" checksum="BCF9F3D69717BD87" modified="2014-04-16" version="1">MDSFEKLPPEVIQQILANIGDFAGIKNSLLASRRLNAVFQAQPTRIIQELILLNPITYMPEIQKLCYNIWHLSISSLQCPDLEHYHQTCEDPPTLGYTESRHILKIGAQIQRLACKCLSIMREGLIKTLDNIPADSISGPPLQIQNASQPFTWTEEYRTYWALWHLHHYSHLRKAAIQRWNWNESSIRELDAYNTWSEIDYRTAERLWTVSAVLSDLGLTLNWLPNDPEAEEPAQTIWPAPEETSIPFFPSFDLPPTQSQDISLWATPDPPEDTELTSAWMLAPRHRASHHWHIAHLYLSGINLTRTVPACYSLTNMKPWRRLGWVIWDGWRMYSIELSNIARKKKIPLPDGGFLEPEPRNPRDQKPGIDYMARWFAMIGEEKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W6QJH2</accession>
    <name>W6QJH2_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S04g001042</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM36161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QJH2"/>
    <dbReference type="OrthoDB" id="5350490at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021295">
        <property type="entry name" value="DUF2867"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11066">
        <property type="entry name" value="DUF2867"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM36161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="63" mass="6989" checksum="49A79BD32CE9251B" modified="2014-04-16" version="1">MRIRDGVMSIFGVKRSTEIQAAAEKKGIDTITVFPVISRAENEIVLGEADSHLNFQISILTRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2024-10-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W6QJM9</accession>
    <name>W6QJM9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S03</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S03g001143</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QJM9"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM34419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="81" mass="9323" checksum="409BC924DD194AEC" modified="2014-04-16" version="1">MQYGGIHGYRGCVPRRRPWVPGYWIKIGVAISFLVSPSLLRSPVSRRSGWTSPQKRKKKEKKERNWAVSRVPNCHVHIAPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>W6QK72</accession>
    <name>W6QK72_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Dynein regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PROQFM164_S05g000229</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat AIP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QK72"/>
    <dbReference type="STRING" id="1365484.W6QK72"/>
    <dbReference type="OMA" id="FYQGPPF"/>
    <dbReference type="OrthoDB" id="2306at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030864">
        <property type="term" value="C:cortical actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030042">
        <property type="term" value="P:actin filament depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000102">
        <property type="entry name" value="Actin-interacting protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000167">
        <property type="entry name" value="Actin-interacting protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19856:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19856">
        <property type="entry name" value="WD-REPEATCONTAINING PROTEIN WDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="54"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="185"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="229"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="322"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="531"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="574"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDM36396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="611" mass="65084" checksum="23B22EBADB8CE360" modified="2014-04-16" version="1">MSLTNESIWAASPSTTRGQPTQLSSDAKGERLAYASNKSIFLRSIDDPAVARQYTEHKAQTTVARFSPSGFYVASGDAAGIVRVWDCVGEGITKGEYSIVNGRINDLAWDGDSQRIIAVGDGKQRYGHCITWDSGNTVGEIHGHTQQLNTVSIRQQRPLRAATAGDDKKTVFYHGPPFKFNNGIADKHSNYIYGVAFSPDGSHLVSVGADRKIWLYDGKTGETKGQIGEGEHTGSIFSVCWAKDSRKFVTASADRTVRIWDVEAGKSTQTWTLGEEGAMAVRDHQVGVVWPPGRTDNLLISLSLSGDLNYLVEGTPEPRQVISGHQKSITSLAQTTVDNKETLWTGSFDGRVCNWDVASGKAEEIEGDAHPGYVAGLATTSEGSGRIYSVGWDDTLRSVDAAAKTYTGSASKLNGQPKGVAAGDTTVLVGEAETVEIFQDGKKTGEYKTDFTATTVAAHGSQAAVGGENGSVQICAISSSRLSPRADINASRNPISALAFSPDASHLAVGDLRGRVLVFKVADGSLVTDRWTAHTARITSLAWNEAGSHVVSGSLDTNIFVWSLAKPGDWLELQNAHKEGVHGVGWISGGSKIISAGADAAVKVWKVDGLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W6QKP2</accession>
    <name>W6QKP2_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S05g000843</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM37010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QKP2"/>
    <dbReference type="OMA" id="MHQFINN"/>
    <dbReference type="OrthoDB" id="4249675at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM37010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="240" mass="26548" checksum="8CE98252679609C3" modified="2014-04-16" version="1">MNIDQLANGMKILTVNTELLISLINGDLVASPIGASTLRMSVRLTELPAYVTSPTFVFEDPKTFEVYLASTAPNATATKLRLAPLHRFIGRRFPEPSLRGLSGDGYCRLSRNKPTEVREFFMALPFPYPSMDGVFIDYVTHPEGLEFITLNSDWRAACRAIPAGHNVQEVIIDLTGAERLNSSYVSRLVQFVTTILALKAKGSFSSRLRADEPYQWMQCVAGAMVSKVVPGSEARDDIRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W6QKU1</accession>
    <name>W6QKU1_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major intrinsic protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PROQFM164_S02g000326</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QKU1"/>
    <dbReference type="STRING" id="1365484.W6QKU1"/>
    <dbReference type="OMA" id="KAWDPEY"/>
    <dbReference type="OrthoDB" id="3222at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015254">
        <property type="term" value="F:glycerol channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015250">
        <property type="term" value="F:water channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050363">
        <property type="entry name" value="MIP/Aquaporin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43829">
        <property type="entry name" value="AQUAPORIN OR AQUAGLYCEROPORIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43829:SF9">
        <property type="entry name" value="AQUAPORIN-9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="Aquaporin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="184"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM30177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="279" mass="29824" checksum="63B2176E93F19CF4" modified="2014-04-16" version="1">MIPRRALKPYAAEFLGTALLIVIGDGVVAQCLLSDYNYGTWLSINLAWAAAVCLSGYLSDPGPTINPAVTLCLALVRPSEGQWKQIPGKLAAQFLGGFVGAAIVYINYRSAIKAWDPEYTIPGGSILSPVGHHSAGIFSTYPGAFFQSNWEAVFSEMLGSAVLMFGLLSISDPGNARRFPAPQIAVFLLLLMIGAALGWQTGYAINPARDFGPRLFSAIVYGREVFTAANYYFVVPLFAPIVGCVLGAATYDGMLFEGEGSRIADALDEAEDHGSLRLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W6QKV2</accession>
    <name>W6QKV2_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Peptidase S59, nucleoporin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PROQFM164_S05g000469</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleoporin GLFG family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1365484.W6QKV2"/>
    <dbReference type="OMA" id="PMGKGLN"/>
    <dbReference type="OrthoDB" id="3797628at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044614">
        <property type="term" value="C:nuclear pore cytoplasmic filaments"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008139">
        <property type="term" value="F:nuclear localization sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000973">
        <property type="term" value="P:post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006405">
        <property type="term" value="P:RNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034398">
        <property type="term" value="P:telomere tethering at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2360:FF:000001">
        <property type="entry name" value="Nuclear pore complex protein Nup98-Nup96"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.690:FF:000003">
        <property type="entry name" value="Nucleoporin SONB, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1610.10:FF:000003">
        <property type="entry name" value="Nucleoporin SONB, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.690">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1610.10">
        <property type="entry name" value="Peptidase S59, nucleoporin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037665">
        <property type="entry name" value="Nucleoporin_S59-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007230">
        <property type="entry name" value="Nup98_auto-Pept-S59_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036903">
        <property type="entry name" value="Nup98_auto-Pept-S59_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021967">
        <property type="entry name" value="Nup98_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23198:SF6">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP98-NUP96"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23198">
        <property type="entry name" value="NUCLEOPORIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04096">
        <property type="entry name" value="Nucleoporin2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12110">
        <property type="entry name" value="Nup96"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82215">
        <property type="entry name" value="C-terminal autoproteolytic domain of nucleoporin nup98"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51434">
        <property type="entry name" value="NUP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="6" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="9" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Peptidase S59" evidence="12">
        <location>
            <begin position="965"/>
            <end position="1107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="52"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="414"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="847"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="917"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1116"/>
            <end position="1138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1198"/>
            <end position="1232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1351"/>
            <end position="1373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="54"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="86"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="421"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="438"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="502"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="522"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="554"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="601"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="622"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="641"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="666"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="694"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="847"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="925"/>
            <end position="936"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDM36636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="2038" mass="214080" checksum="3DB42EA84072BD1A" modified="2014-04-16" version="1">MSFGFGGFGSNNQSSGFGTGTGFGAGTSTGGGRSFLSPFSNSPCTLGPYPHVSHSTRRHHNKIRNARASSNPSLSDRDPLRHLGFGSTASPFGGATTGTSSAFGSTPSTSTGFGTGGGFGTNTTPQQPNALFGGQTRPGGFGTPNTPNTGSLFGGGTQTAGTTGGFGAGGGFGSTGTTGGFGANASATPAGGSLFGGAKPTGFGTATGTSAFGTSGGFGSTAAPTTTPSTGFGGSGTAFQGGLPNCEGTGSTPFSPWNEKDTSSANTTNHYQSICFMQPYSKWSFEELRLADYQQGRRFGNGSGQAGGFGAPAFGNTTTGGFGQQNTTATPAFGASTTPFGGAATSAPTGFGATQTAGGFGSTGANPLFGSAAKPATSLFGGTTPAASSGSLFGGATQTAGGFGGNTGTGSAFGNTGGSLFGSNNQQQQNKPAFGATGTTGGAFGGFGNTQTTTAANPFGAPTATASPFGGGAQQQAPSAFGGFGGANQQNQAQTQPKSLFGGFGGTPQQGAGTGLLGGAGSTPAAGSSLFGGAQQQPQQQGGSSLFGGQNQQAGTGSTLFGGSQNQQKPGGLFGSTPAPTTGGFSGFGASQPQPAAGGSSLFNTQNQQQQKPGGLFSSTTGTGGGGMFGGGQTNTGQGAGSSLFGGQNQQPQGGLGVSAFGASMPGQQSQPAPGSFQASLLDGNPYGSQSIFSGLPAPGGSAPGPLATPLSSSMKQKQRTPLPVYRITPNAANRLITPPKRGYGFSYSTYGSPSGSTGASSGLGSSLLGGAGGSSSLRGSVNGSIGRSFSKSYSTSNLRKTFDPEADSILSPGALQAGSVRGNSSLKRLTINRGLRNEIFSTSRIAPAPLHTPAPLLTNGEDAHSSDKLKKKVSFDSHTSGVNGGELVHVEPNSSEPSAEELGFLRSVRKSGSLNGFDAAGTSDRPEAESARRDLAVVPESAPQTTNGATVKRLTFIPGGDPRPGEYWMQPSRAELSRMSRDQLRQVVDFTVGRQNCGSVTFNGPVDLTTVDLDNLFSNIVDIGLRKITVYPEESVKPARGKGLNVPSTLRIENSWPRGRDKKSNSPVTSGPLFDKHIDRLQKVGDTEFVNYETETGTWVFKVPHFTTYGLDYDEEEGESHDQSTMSAQGPDHATSRAHFDPASFDQSTFSIDESFVGSMIGVEDDTFDFKKRKLVPGSFANQAMPVEDDYFSDGETESFLEEGSTGSTTENDDDVVTESQQSGDSVVGSDEADEMDMAGAFPTPHRTVERNDYQSTNGDLDTTYHMSRHFGSPAKPQLDLSGDWAEQLQRTISPRKQNRDALREMQASAFIDRNLVNDESPTNIATASPKKGFSNSIDLMNSLFQQPRKQAAPSPLKAKATPKGFEWPYNKQPKTFAGDTTQMSESDAAFHDSFKPRWGPMDSLICVKNDMGDTILGVNQTWKESFSIFSEDRDIAVMTYNQSSEVREMLDVQRLQSSIQRIDGTPFVRMARIDLSQFPLSPSTRSQSEEERLVWQLLNILFNDDIEDDISAGVPPRLRQQFAHRIRKDRLTRLWEGIIREKHSQNLDAIRSPVERAVHLICSHRVEEACKTLIDSQNPHLATIVAQIGRDATSRADIANQIDVWRQNNILSEMTEPIRALYELVAGNALRSEGKSGGALEDRASSFGFTERFDLDWFQAFGLRLWYCTAEDEPIEVAVSKFLADLATGQEPAFPHPSHQASTRAVPQPGSDTLGRESPLWVLLKAFSAIQGHVTQPVEFPASFLPESVSGDRLSNRLSFQLHHVLAAVVGKNQAIKINQHQTDQLVRDFASELSAGGKLDQALFVLLHLSQGNDRKGAVQETLARFAAQLPEPFAADGSSDLAWQYLITDLQLPEAWIWVAKALYARDIGDSAREVDCLIRGKHWNDAHTTFCRIVGPSTIIEGDYRTLETLVSGFGDAPERKMRGWSSGGGVYEDFLRLVNSTSGRRDPIRLNRLVNALVAMGDRVQGSSLEGLEERVAFKEMSRAVAGWITHEDVHSVESSAVLGLPLTGDARVLQTAEMSRRYYGVIMAGGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W6QL61</accession>
    <name>W6QL61_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">tRNA (guanine(26)-N(2))-dimethyltransferase</fullName>
            <ecNumber evidence="7">2.1.1.216</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">tRNA 2,2-dimethylguanosine-26 methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">tRNA(guanine-26,N(2)-N(2)) methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">tRNA(m(2,2)G26)dimethyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">trm1</name>
        <name evidence="14" type="ORF">PROQFM164_S03g001656</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>guanosine(26) in tRNA + 2 S-adenosyl-L-methionine = N(2)-dimethylguanosine(26) in tRNA + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:43140"/>
            <dbReference type="Rhea" id="RHEA-COMP:10359"/>
            <dbReference type="Rhea" id="RHEA-COMP:10360"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:74513"/>
            <dbReference type="EC" id="2.1.1.216"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.216" evidence="7"/>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QL61"/>
    <dbReference type="STRING" id="1365484.W6QL61"/>
    <dbReference type="OMA" id="MKCCHEM"/>
    <dbReference type="OrthoDB" id="6349953at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160104">
        <property type="term" value="F:tRNA (guanine(26)-N2)-dimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002940">
        <property type="term" value="P:tRNA N2-guanine methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.56.70:FF:000001">
        <property type="entry name" value="tRNA (guanine(26)-N(2))-dimethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.56.70">
        <property type="entry name" value="N2,N2-dimethylguanosine tRNA methyltransferase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002905">
        <property type="entry name" value="Trm1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042296">
        <property type="entry name" value="tRNA_met_Trm1_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00308">
        <property type="entry name" value="TRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10631">
        <property type="entry name" value="N 2 ,N 2 -DIMETHYLGUANOSINE TRNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10631:SF3">
        <property type="entry name" value="TRNA (GUANINE(26)-N(2))-DIMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02005">
        <property type="entry name" value="TRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51626">
        <property type="entry name" value="SAM_MT_TRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 12 14" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 12" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 12 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 12" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="1 12" id="KW-0820">tRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="129"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="493"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="662"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="724"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="188"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="496"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="665"/>
            <end position="676"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00051897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00077143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00082896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00083299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDM34929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="747" mass="81983" checksum="7DE8DE288A750AD0" modified="2014-04-16" version="1">MNASLIFGSATRRGKRILIPTIILAQSPRPTPTSIRYCVRFLSTSRAMEVPQTQLVEYQGDNYHVVKEGLAKILNPPAQAAASKGTKKDLKDDDQAQSVFYNPIQQFNRDLSVLAIRAHGEHIIDLKKQKAAQKLKKQAGNGDKKRKREDNQTENPRPASKAENKETIETNDQPVPAALVPAPAVDQGPQSEAQPEQPASFTVLDALSATGLRALRYASELPFVTKVVANDLSESAIKSMKKNIDYNNLQTIKPNLADARVYMYGLDHASKFDVIDLDPYGTAAPFLDAAVQAAKDGGLLCVTCTDAGVWASTGYSEKAFSLYGGIPIKGLHSHEGGLRLILNSIAMSAAKYGMAIEPLLSLSIDFYARVFVRIHRSPAQVKFLSGNTMLVYNCDVGCGAWSTQPIGSTKSRLDRKGNPIYHHGLAKGPTAGPNCEHCGTKTHLAGPMWGGPLHNPDFIQKILDMLPGADPETYQTCPRIEGMLTTALEEDLDLTPSDSQPSTPKQPAPSTKNQHDSAYPAIIPRMDVAAREKYPFYFSLSALSKVIHSTTIPIDEFRGALSHLGYRSTRSHTKPNSVRTDAPWEVIWEIMREWVRQRAPIKEASLKPGTPGAAIMGKSRENLRKLNDEDQWLSLLKKDLMSAVEAGRDVSDLVTKVEAALYRSGSRNSSQRTAASAETRPNADPQPVPEKEKSPAQPFKRPHPSTLEVVFDEALGREVSAAHTKKRLVRYQLNPRANWGPLNRAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W6QL92</accession>
    <name>W6QL92_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S06g000186</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792020">
        <property type="protein sequence ID" value="CDM37225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QL92"/>
    <dbReference type="STRING" id="1365484.W6QL92"/>
    <dbReference type="OMA" id="CLKCALT"/>
    <dbReference type="OrthoDB" id="4160690at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004880316" evidence="2">
        <location>
            <begin position="19"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM37225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="218" mass="21831" checksum="79F5B532BE2B805D" modified="2014-04-16" version="1">MRLVNLAALACAVISASAFDFPEFVPLHRRQEAGTPAYECHANCGGVIVDGRTDGYCDTDEFTTELAACLECALEYDIWQYYGTSVSKAATACGLDATPVEASSTTTSASATTASDSETTTSDSASATETAESVTSAESTAAATTSASTSIATTSVSPPRVSGSPRPSSLIPSATPTGSSTASSTPSSTPVYTDGATINMGSGLVSGAVVGCLLAAFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W6QLD8</accession>
    <name>W6QLD8_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Vacuolar protein-sorting-associated protein 25</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">ESCRT-II complex subunit VPS25</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PROQFM164_S05g000619</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VPS25 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QLD8"/>
    <dbReference type="STRING" id="1365484.W6QLD8"/>
    <dbReference type="OMA" id="TRCLIMW"/>
    <dbReference type="OrthoDB" id="245150at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000814">
        <property type="term" value="C:ESCRT II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000141">
        <property type="entry name" value="vacuolar protein-sorting-associated protein 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.570:FF:000003">
        <property type="entry name" value="Vacuolar protein-sorting-associated protein 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.570">
        <property type="entry name" value="Winged helix' DNA-binding domain. Chain C. Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008570">
        <property type="entry name" value="ESCRT-II_cplx_Vps25-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014041">
        <property type="entry name" value="ESCRT-II_cplx_Vps25-sub_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13149">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VPS25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13149:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN-SORTING-ASSOCIATED PROTEIN 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05871">
        <property type="entry name" value="ESCRT-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM36786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="202" mass="22769" checksum="B5F618FD4FC22ED0" modified="2014-04-16" version="1">MTTTPPFPFPPTYNFPPFFTPQPNTTTRHSQLEKWSSLIQSWCRHHRQYRLSLIDAVETPLFHNTALRKRLDLREARAVIDWMTKSEEEGGGGRRAEWISDAGGASSLGGLGNGAGQGPKAVAWIWWRRPEEWADVLVEWVEGTGQRGSVLTVYELIHGEGAMSQEFHGMDTDVMLRSLNVLVKRGRAQIFGAEGQEGVKFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W6QLQ6</accession>
    <name>W6QLQ6_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Carotenoid oxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PROQFM164_S04g000030</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM164</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="5">Binds 1 Fe(2+) ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the carotenoid oxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QLQ6"/>
    <dbReference type="STRING" id="1365484.W6QLQ6"/>
    <dbReference type="OMA" id="SCMAFHR"/>
    <dbReference type="OrthoDB" id="407010at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010436">
        <property type="term" value="F:carotenoid dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016121">
        <property type="term" value="P:carotene catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004294">
        <property type="entry name" value="Carotenoid_Oase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10543">
        <property type="entry name" value="BETA-CAROTENE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10543:SF24">
        <property type="entry name" value="CAROTENOID ISOMEROOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03055">
        <property type="entry name" value="RPE65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="345"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="547"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR604294-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDM35149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="562" mass="62055" checksum="FD7C747940283770" modified="2014-04-16" version="1">MPSIGPDPIAMENDRTEDYYNNWPNDKGFDPEYEQRKPVELSVIGHIPAYAAGVLYRTGPGKSHVEAENGETLRLSHWFDGFGQNHRFQIFAPDDSCTSPRVFYNSRFSTDDQIELARKTGSLRTISFGQKRDPCKSVLGKVQTEYVAQPTPSSKNISVTLSINVPGLDPKPDESKSASRWSDSRGIRTLYAKTDYNAFQKLDPETLEPIGLASQTSLHPELSGHLAASHARSDPITGDMFNYNLTLGPTCTYRVFGVSASTGATTILATFPATPVYIHSFLITEDHILLCLWNSHIKPREFDSSFIDAISPTDPSQPAVWHVIDRKHGKGLIATYESPAFFCFHTVNAWLEPSKENPAELDIVADVVRADSSECLQSLYYENLISSLDTAKAFQKKKDDSFRSSFTRFRLPAVPSAPCTEPKKAIVEWSVCKSLSPELPTLNPKIVTQKHQYVYAVTFRGEATLTDGIMKLDCDTQQVQLWACHGQSPGEPIFVANPEGTSEDDGVLLSVVLDGMRSKSYLLCLDARNLSELGRANVDGAVGFGFHGQHVPTVGGMPTGDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>W6QLR7</accession>
    <name>W6QLR7_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 14 17">Homoserine dehydrogenase</fullName>
            <shortName evidence="14">HDH</shortName>
            <ecNumber evidence="5 14 17">1.1.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">PROQFM164_S02g000661</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the conversion of L-aspartate-beta-semialdehyde (L-Asa) to L-homoserine (L-Hse), the third step in the biosynthesis of amino acids that derive from aspartate (the aspartate family of amino acids), including methioinine and threonine, the latter of which is a precursor to isoleucine; production of homoserine leads to a branch-point in the pathway as it can either be O-phosphorylated for processing to threonine, or O-acylated for processing to methionine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-homoserine + NADP(+) = L-aspartate 4-semialdehyde + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15761"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="1.1.1.3"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="12">
            <dbReference type="Rhea" id="RHEA:15763"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:25213"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 17">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 3/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 17">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 14 18">Belongs to the homoserine dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.3" evidence="5 14 17"/>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QLR7"/>
    <dbReference type="STRING" id="1365484.W6QLR7"/>
    <dbReference type="OMA" id="IYTRCYS"/>
    <dbReference type="OrthoDB" id="67851at2759"/>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00063"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004412">
        <property type="term" value="F:homoserine dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009090">
        <property type="term" value="P:homoserine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000006">
        <property type="entry name" value="Bifunctional aspartokinase/homoserine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005106">
        <property type="entry name" value="Asp/hSer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011147">
        <property type="entry name" value="Bifunc_Aspkin/hSer_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001342">
        <property type="entry name" value="HDH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019811">
        <property type="entry name" value="HDH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022697">
        <property type="entry name" value="HDH_short"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43070:SF5">
        <property type="entry name" value="HOMOSERINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00742">
        <property type="entry name" value="Homoserine_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03447">
        <property type="entry name" value="NAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036497">
        <property type="entry name" value="HDH_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01042">
        <property type="entry name" value="HOMOSER_DHGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14 17" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="11 14 17" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="9 14 16" id="KW-0521">NADP</keyword>
    <keyword evidence="10 14 17" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 14 17" id="KW-0791">Threonine biosynthesis</keyword>
    <feature type="domain" description="Aspartate/homoserine dehydrogenase NAD-binding" evidence="20">
        <location>
            <begin position="12"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="Homoserine dehydrogenase catalytic" evidence="19">
        <location>
            <begin position="155"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="15">
        <location>
            <position position="228"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="12"/>
            <end position="17"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>NADPH</name>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>NADPH</name>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>L-homoserine</name>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00059589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR036497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR036497-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR036497-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU004171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF03447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="CDM30512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="370" mass="38695" checksum="FE26867933039EFB" modified="2014-04-16" version="1">MSASPIYLGVIGVGGVGTAFLQQLARLPNAPQLVLLARSSQTLLSPSPAYSPAIPAADWATAAAAPSLTKSGALQAEEIATYLASAPGRAILVDNTSDISLARQYPTFLKKGISVVTPNKKGFSDDLSLWKDIFASAAEGKALVYHESTVGAGLPVLSTLKDLVATGDEVTRIEGVFSGTLSFLFNTFAPASGASDAQWSAVVAQAKELGYTEPDPRDDLNGMDVARKLTILARIAGLEVSRPDSFPIESLIPAELASLPSSADGITQFMTRLPEFDAQMANIKDTAEKQGKVVRYVGSIDVAAKAVKVGLQYFDKDSAIAGLKGSDNIISFYTKRYGANPLIVQGAGAGGEVTAMGVSADLIKVVERLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2024-10-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W6QLV5</accession>
    <name>W6QLV5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S02g000696</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QLV5"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM30547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="37" mass="4081" checksum="0600FA218770EE6D" modified="2014-04-16" version="1">MGDGASKEFFSARNSQDRRHATQPGSVWDSPMLLTAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W6QMJ7</accession>
    <name>W6QMJ7_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transport protein particle (TRAPP) component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S06g000607</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAPP small subunits family. BET3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG792020">
        <property type="protein sequence ID" value="CDM37645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QMJ7"/>
    <dbReference type="STRING" id="1365484.W6QMJ7"/>
    <dbReference type="OMA" id="CKEFWTA"/>
    <dbReference type="OrthoDB" id="941624at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005801">
        <property type="term" value="C:cis-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030008">
        <property type="term" value="C:TRAPP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14944">
        <property type="entry name" value="TRAPPC6A_Trs33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1380.20:FF:000020">
        <property type="entry name" value="Trafficking protein particle complex subunit 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1380.20">
        <property type="entry name" value="Trafficking protein particle complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024096">
        <property type="entry name" value="NO_sig/Golgi_transp_ligand-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007194">
        <property type="entry name" value="TRAPP_component"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037992">
        <property type="entry name" value="TRAPPC6/Trs33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12817:SF0">
        <property type="entry name" value="GEO08327P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12817">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04051">
        <property type="entry name" value="TRAPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111126">
        <property type="entry name" value="Ligand-binding domain in the NO signalling and Golgi transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM37645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="187" mass="21099" checksum="F658CD06D8D5F0E6" modified="2014-04-16" version="1">MSFDSTSPSNADPNARVFSSSCFDFLLIELVPMAERMAKELATEGQEAEDEEVRETIFFRLESLGYRVGQGLAERFARDRPRFTDNLDVIKFLCKDLWTVLFKKQVDNLKTNHRGVYVLTDSAFRPFGRMSMAVRTEAISMAQAYLWFPCGIIRGALANLGINTTVQAETSDLPGATFQIKTLQPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W6QMU9</accession>
    <name>W6QMU9_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glucosidase 2 subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PROQFM164_S02g001087</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QMU9"/>
    <dbReference type="STRING" id="1365484.W6QMU9"/>
    <dbReference type="OMA" id="YENGQHC"/>
    <dbReference type="OrthoDB" id="28322at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017177">
        <property type="term" value="C:glucosidase II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006491">
        <property type="term" value="P:N-glycan processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.130.10">
        <property type="entry name" value="Mannose-6-phosphate receptor binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039794">
        <property type="entry name" value="Gtb1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009011">
        <property type="entry name" value="Man6P_isomerase_rcpt-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044865">
        <property type="entry name" value="MRH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036607">
        <property type="entry name" value="PRKCSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028146">
        <property type="entry name" value="PRKCSH_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12630:SF1">
        <property type="entry name" value="GLUCOSIDASE 2 SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12630">
        <property type="entry name" value="N-LINKED OLIGOSACCHARIDE PROCESSING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12999">
        <property type="entry name" value="PRKCSH-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13015">
        <property type="entry name" value="PRKCSH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50911">
        <property type="entry name" value="Mannose 6-phosphate receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51914">
        <property type="entry name" value="MRH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004881775" description="Glucosidase 2 subunit beta" evidence="6">
        <location>
            <begin position="20"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="domain" description="MRH" evidence="7">
        <location>
            <begin position="432"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="182"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="399"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM30937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="569" mass="62885" checksum="CC63DA11D0A0D831" modified="2014-04-16" version="1">MRLPQSLFLLAAAGSAVQASSDKPARPRGLGPEFAKFYQDSTTFTCISNPSVKIPFSAVNDDYCDCPDGSDEPGTSACAHISRNSPLTVADRPGNSELDTVLALPGFYCKNKGHRPSYLPFQRINDGICDYEECCDGSDEWARVGGTKCEDRCKEIGKQWRKQEEQNQKSMNAALRKKKDLLVDAGRQQQELEDHIAALEAEVQGAELKEQNLEADLKLAQEQDRKVVRTGNGKGNGKVNALANLAKGRVDELRNALVDVRRQRDEVRERVKELEDILAKVKVEYNPNFNDEGVKRAVRSYEDYAAREQGTEGVNAAVDRDLDEIAKADGEEHGINWEHWENEEDGCNDSDLVYKLAAYLPPSLVSFIEDRAVSVRSYLEEKGILPKADKDSSSESKAVTQARDALKAAQDTVTSIKNKLRDHRADLEQDYGPNSIFRALKGVCITQDAGEYTYEHCFLESTKQNQRKGSNSVSMGKFSNVGTTTVEEVNAAGEVVNVEKMTIQYNNGQSCWNGPNRSTKVILECGEENKILKTAEEEKCVYAMLVTSPAACASGEEAGNVAPRSKDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W6QNF6</accession>
    <name>W6QNF6_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Flavin reductase like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S07g000264</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792021">
        <property type="protein sequence ID" value="CDM37915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QNF6"/>
    <dbReference type="STRING" id="1365484.W6QNF6"/>
    <dbReference type="OMA" id="DQRRYTS"/>
    <dbReference type="OrthoDB" id="2015405at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042602">
        <property type="term" value="F:riboflavin reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002563">
        <property type="entry name" value="Flavin_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050268">
        <property type="entry name" value="NADH-dep_flavin_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30466">
        <property type="entry name" value="FLAVIN REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30466:SF1">
        <property type="entry name" value="FMN REDUCTASE (NADH) RUTF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01613">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00903">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavin reductase like" evidence="3">
        <location>
            <begin position="99"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="35"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM37915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="301" mass="32731" checksum="3E6C7F21EF8A7DAA" modified="2014-04-16" version="1">MKLVFPAHGTARTALGELSCINNYTPLFLGTSLSLRTSPPVPYTKHRSRSDQRRYTSNSTAPSKENGRTGKPNAPSHADNTPQPPTPSTSISDQVRLLMRRVPYPVAIITATDPSGSENITSFRGMTVSSFSTVTLTPDPVISFNVRRPSETLNALLASRRFLVHLLAPSPATATLARDFSKGNIALASMLRGHGEFEFAALPTKDEQGYPSRSLPILKRRAEAIAVDDAVEFPFVFECTLHPQKIDVNDHSIVLGTVVRAVEGSGSVLALGQDDKALNDLPERLCLTYANTKFWKMGGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W6QPP7</accession>
    <name>W6QPP7_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PROQFM164_S02g001702</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QPP7"/>
    <dbReference type="STRING" id="1365484.W6QPP7"/>
    <dbReference type="OMA" id="RQIAHME"/>
    <dbReference type="OrthoDB" id="2110130at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03221">
        <property type="entry name" value="ABCF_EF-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:003119">
        <property type="entry name" value="ABC ATPase, putative (AFU_orthologue AFUA_1G16440)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000011">
        <property type="entry name" value="Putative ABC transporter ATP-binding component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032781">
        <property type="entry name" value="ABC_tran_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050611">
        <property type="entry name" value="ABCF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211:SF135">
        <property type="entry name" value="ATPASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G16440)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="50"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="483"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="50"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM31552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="739" mass="82119" checksum="18F5EB5746008D1D" modified="2014-04-16" version="1">MTSAPTILATCKQTRFHLLDDNPSQEIDVEGLNIIVTSSAPESTEDASKPKTKGKSRAKAAGRELISDAHLRLKAGVHYGLLGRNGTGKSTLLRAMAEKLIPGIPHATRMAILQQTDQQDDVTFGEDPNQDKTVLEAVLSSDESRNEAVRMTEFLSKSFETEDPMQPVRAIRKIRHQKAEKHLFLAHKNASLKSGARGLQARKDLKAAEGKLEAASEMLAQDVAAIDAETVQSDTQAAVETLQNLQSQIEDMKLADMKQQARRVLLGLGFKEDGFEKKVSTLSGGWRMRCMLASVLVQDPDIMILDEPTNFLDLLGVVWLENYLKQLRDTSETTIVLVSHDRDFINAVCEEIVILRDQKLTYFRGNLSAYEQDFEEQKLYLGRMKEAQERQVAHMEASIRENMKIGKKTNDENKLRQAKSRQKKVDDRMGLQVSANGGRFKLNRDLVGWHLHNRAEIDVPTDEKGATMSLPDATELRFPGPLVSLEGIVFQYKKTDRVILDDVNLVVHLGDRVGIMGLNGSGKTTLLRILTGQVSPSKGKVSTHSRLKVGYYSQHSVEELQERGRGEPSLTALGLLTIETEGSLNEGAIRGLLSSMGLAGRIASDVPVAKLSGGQLVRLALARIVWSAPQLLILDEITTHLDFHTVTALATALSSFNGAVLLISHDRFLVRSVIEGKRDTEHKLDEDFEGLEEEETEETPRRRSVYVIKQGKMNEQKNGVEQFEKSLVKRVQKLLATID</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W6QQ92</accession>
    <name>W6QQ92_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type DNA-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PROQFM164_S09g000072</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792023">
        <property type="protein sequence ID" value="CDM38156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QQ92"/>
    <dbReference type="STRING" id="1365484.W6QQ92"/>
    <dbReference type="OMA" id="QACTHCY"/>
    <dbReference type="OrthoDB" id="1600564at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF18">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDM38156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="630" mass="71361" checksum="FF4361D4C56094EF" modified="2014-04-16" version="1">MERSNPALSQSSTYGQACTHCYKAKSRCVRTPNGDKCERCLRLKKRCQPSESVRRRNAQAAGSSDSRIARLEDKMEILLSAMQSFVSQGASGTSANVPEPLQPALSLDGNIISSSTSHSNGTLVNTSAGLNISEGPTFATDSIVTTPPNLTQEDERLDFFRSRMLPCFPFIDFTPDMTNSYLRQNRPFLLQAIHTVTIFSTQERLGQIEELKRILFTSALREVQSNIDLLLGLLTYLAWSTDAFLGRADLVSRLMMLAISIVYDLRLFKPSSPDVKAIMSLTQGQAEEPHSPNDQLPDGFLERQRALLACFILSSNVSSHLGRQDAIRWTPQMEEALRVITLTKSCPADELFVFQVHLQLLKQKADYVRQQDEIGGTRTGTAPAAASAPRFFYLKTLRTQLHDLKSSFPPDLYHIDILNTHAQYVELYINQLGYSISRDSLSLDQSGRISDGGVVLEFQRPECLWQSVENIKSWLDEFYRIPCSKLFGQPFHFWSQMILSITLLKYLSTLEDPQWDCQAVRNTVDLISTMDCMLHKLDLSSKEPELQFNDHFLKLLFKLLTKCRLWAEARWTMASQLQDMGTRPCQSADSDMTSRNHHIPDLDQMAWMQSMDLGNDQWFEDVLGIPTAFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W6QR59</accession>
    <name>W6QR59_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S05g000387</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QR59"/>
    <dbReference type="STRING" id="1365484.W6QR59"/>
    <dbReference type="OrthoDB" id="2156052at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM36554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="78" mass="8706" checksum="0E11C5B26A412049" modified="2014-04-16" version="1">MSTEIDELRRLLAEENEKTSKTNLPASLDGVPNHFFHGLAVQQDKTRSTRGDPATATNKPRPRRLKASGSFAKEQEDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W6QRD4</accession>
    <name>W6QRD4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S15g000005</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792029">
        <property type="protein sequence ID" value="CDM38541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QRD4"/>
    <dbReference type="OrthoDB" id="4360605at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM38541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="66" mass="6819" checksum="3DD9B6A10A232205" modified="2014-04-16" version="1">MAHNSKSSGNGVGRGAAKVKPRAGRSCTDSPCSDRSTVPTSKADRDPLKPVAKLYKGLGYSVIKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W6QRM8</accession>
    <name>W6QRM8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Pyridoxal phosphate-dependent transferase, major domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PROQFM164_S05g000547</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QRM8"/>
    <dbReference type="STRING" id="1365484.W6QRM8"/>
    <dbReference type="OMA" id="KNWRYPG"/>
    <dbReference type="OrthoDB" id="2108at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050596">
        <property type="entry name" value="AspAT/PAT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46383">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46383:SF1">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="7">
        <location>
            <begin position="106"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="81"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM36714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="482" mass="53624" checksum="E275ABA366DF59A0" modified="2014-04-16" version="1">MSFSGRRLSILRPSENRNPSAKKELSDNELNSETHRQFREAHEGHRPHAGLDASRASTGVVWCTERACEHGYADDPSSWANLGQGAPEADDGIEGSFPRPTAIPITSASREYGPTAGIKPLRAAVARLYNDHYRQGKESQYTWENVCIVPGGRAGLIRIAAILGNSYLSFPIPDYSAYSEMLSLFKNIAPIPLPLSKEDHYHIHPNKIAEEIARGTQVLLTSNPRNPTGHFMPQDELQQIQDLCRDRATLILDEFYGGYNYTTGCDGTTISGASNVVDVNKDDVLLIDGLTKRFRLPGWRIAWVVGPKDFVDALGSAGSYLDGGANVPFQEAAIPMLEPWLVRTEMKALQQHFMEKRDYVLGRLYDIGFRVQDVPGATFYVWLDLTSIEPPLPEEANISDGLNFFSALLTQKVIVVPGIFFDLNPAKRRDLFDSPCHHFVRLSYGPKMDVLKRGLDGIERVVKRARLMGAPKWDAEVAVADE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W6QSY6</accession>
    <name>W6QSY6_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S02g002773</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QSY6"/>
    <dbReference type="STRING" id="1365484.W6QSY6"/>
    <dbReference type="OrthoDB" id="5350673at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM32622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="153" mass="17150" checksum="2C01FDE11CDB920C" modified="2014-04-16" version="1">MYIATSSETCEASVYLNTGLKYYDQSLALFRDELNDITPQNCNAIFANSIVTVAVTVTSSLLMDTNREHSSKTDNAVILINLELFPHNECWDNAVAKLDVDTSTALAHLATLNDKIMISIFAEQYRTNKKLISHLRHYYAEFARSARLSPVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>W6QTL0</accession>
    <name>W6QTL0_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">E3 ubiquitin protein ligase</fullName>
            <ecNumber evidence="15">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">bre1</name>
        <name evidence="19" type="ORF">PROQFM164_S06g000451</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">E3 ubiquitin-protein ligase that mediates monoubiquitination of histone H2B to form H2BK123ub1. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation and is also a prerequisite for H3K4me and H3K79me formation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 15">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 15">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the BRE1 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="15"/>
    <dbReference type="EMBL" id="HG792020">
        <property type="protein sequence ID" value="CDM37489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QTL0"/>
    <dbReference type="STRING" id="1365484.W6QTL0"/>
    <dbReference type="OMA" id="YRQMQEY"/>
    <dbReference type="OrthoDB" id="654191at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033503">
        <property type="term" value="C:HULC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16499">
        <property type="entry name" value="RING-HC_Bre1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058643">
        <property type="entry name" value="BRE1-like_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013956">
        <property type="entry name" value="E3_ubiquit_lig_Bre1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23163:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE BRE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23163">
        <property type="entry name" value="RING FINGER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08647">
        <property type="entry name" value="BRE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26095">
        <property type="entry name" value="CC_Bre1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 15" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="11 15 16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 15" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9 15" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 14 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="18">
        <location>
            <begin position="679"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="242"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="76"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="186"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="279"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="627"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="17"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="245"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00059679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU365038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CDM37489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="731" mass="82487" checksum="9C33340564A6FD72" modified="2014-04-16" version="1">MPAVEPPVKSSESGLIKMEDRKRPAADHNDSAPPLKKQATPPPPPLKKQATTVNGGSKPHPDADMPWKDDLERFQKEAILRQMQEYKREKSSLESRLSQMSKAATFHNDHLRVIDLWFKQLIDEVKLLLGPPQAEDQETPFKSSLQFEDVEEFETHLKSRSEDIHAIISQVQSKSNDAPIEISEVQTRLAKKLAEEKVTIAELEKTLAEKQQLEESLEEASLRYLVAEKKLDRAKSLTVAKLEKQQSMGIQRPGETSQSKREGSTPANGTPAGDRNPELEEANNKLTAISETQKEQVRKLEAENASLLGQITEIKVKSSKFTDDDYAHTDLFKHLRSQYDDVVKRINHLEATNVQLREEAEKYRSERIAYKIQVEDETQSTIAEKEAQLMRAETDLARIRNARDELLADQQMRKAAQDQKKTSSLKLQELADAREARITALESESQRLRLQIEGSKSDDNINDMPLEELRAKYTSLERQYSMLNTELTSMQTAYTKFATLASQKVTDFAAMEERVARLTAEKSKADQKFFAAMKSKEARDVEVRTLRMQSSKTSDIVAQLKESEAATRSLVSNMDKQANETKEALNSALSKHRALQQQLTESNILMEGLKHQVSELKGLSTSKDSTLASTTSALRQAETEVAGLKQSLSDTKKSLDNWKTKSLGNSSSEYEMLRTLALCTVCRRNFKNTVIKTCGHVFCKDCVAERLTSRSRKCPNCGKSFGSNDHMHITL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W6QU52</accession>
    <name>W6QU52_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Hydantoinase/oxoprolinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PROQFM164_S07g000012</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxoprolinase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792021">
        <property type="protein sequence ID" value="CDM37664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QU52"/>
    <dbReference type="STRING" id="1365484.W6QU52"/>
    <dbReference type="OMA" id="RREFNFN"/>
    <dbReference type="OrthoDB" id="3643at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017168">
        <property type="term" value="F:5-oxoprolinase (ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049517">
        <property type="entry name" value="ACX-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008040">
        <property type="entry name" value="Hydant_A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002821">
        <property type="entry name" value="Hydantoinase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003692">
        <property type="entry name" value="Hydantoinase_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045079">
        <property type="entry name" value="Oxoprolinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365:SF2">
        <property type="entry name" value="5-OXOPROLINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365">
        <property type="entry name" value="5-OXOPROLINASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19278">
        <property type="entry name" value="Hydant_A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05378">
        <property type="entry name" value="Hydant_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01968">
        <property type="entry name" value="Hydantoinase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02538">
        <property type="entry name" value="Hydantoinase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydantoinase/oxoprolinase N-terminal" evidence="4">
        <location>
            <begin position="9"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="Hydantoinase A/oxoprolinase" evidence="2">
        <location>
            <begin position="234"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="domain" description="Acetophenone carboxylase-like C-terminal" evidence="5">
        <location>
            <begin position="547"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="domain" description="Hydantoinase B/oxoprolinase" evidence="3">
        <location>
            <begin position="736"/>
            <end position="1273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF19278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDM37664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="1274" mass="138005" checksum="64221C94B0D2B262" modified="2014-04-16" version="1">MSDSGKITISIDRGGTFTDVHAIQPGRPDIILKLLSVDPSHYQDAPTEGIRRILELATGEPHPRGQPLRLDRIGCLRMGTTVATNALLERKGARSALFTTKGFRDLLKIGDQSRPAIFDLSMARPGVLPESVVEVNERVLSCHPSADSACFSDCRLVEGITGENFRVVQELDLVQVKAELQRLKEQGILSISVALLHSYAYPEHERQIGELAQEMGFSVTLSSNLQPMIKIVPRGMSAAADAYLTPVIKTYIDSISSSFEGGLESQQKCRFEFMQSDGGLVDFRKFSGLKAILSGPAAGVVGFAATSWDPTEKTPVIGFDMGGTSTDVSRFDGHFEHVFASKVAGVIIQSPQLDINTVAAGGGSILTWRNGLFYVGPESASAHPGPACYRKGGPLTVTDANLFLGRLLPEHFPKIFGPNENEALDTETTARLFNELTQKVNIERRQQGQSEFSPEEIALGFLHVADESMSRPIRNLTEARGFETASHHLACFGGAGGQHACSVAKTLGISRIIIHKYSSVLSAYGLALAEVVKESQEPVSSAYLSSQSTLLQRLDNLSASATKDMESQGFPSTQVRHEQYLNMRYEGSDTSLMIRKPENSDFLEAFRIRHRREFNFNSDRPVLVDDVRVRTIASSKVRTEQSPLVQLKEADLRDVAPALNTTSAYFGQLGRVDTPVYLLGALEKNSRIHGPAIIIDQTQTIVVAPNAVANLLDTCIVIDLNDEPTSSGSALSSEIDPIRLTIFGHRFMSIAEQMGHTLQKTSVSTNIKERLDFSCALFSPDGGLVANAPHVPVHLGSMQFAVRYQHEKWLGNLKDGDVLVANHPSCGGTHLPDITVITPVFDRPGGSEIMFYVASRGHHADIGGILPGSMPPKSTELWQEGAAIEGDKIVSDGILDEARLIELLVTKPSKYPGCVGARCISDNLSDLKAQIAANTRGISLIQTLFNEYGTQTVQKYMYAIQATAEAAVRNLLKELYQKFNGQPLESVDYMDDGTPIRLKVTINGAEGSAIFDFEGTGPEVYGSWNAPIAITHSAIIYCLRCMINADVPLNQGCLAPIDIRVPSSSILSPSKTAAVVGGNVVTSQRITDVVFKAFQACAASQGCCNNLTFGRDAKLDSSTGAVITPGFGYYETIAGGSGAGPTWRGESGIQVHMTNTRITDPEILEKRYPTMLRQFALREGSGGQGRNPGGEGVIRDIEFLSPIQCSILSERRVHRPYGLEGGQDAQTGFNLWITRDPDTGNERRINIGGKNTVSMKTHDRVVINTPGGGGWGAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2024-10-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>W6QXH3</accession>
    <name>W6QXH3_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S03</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S03g000961</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QXH3"/>
    <dbReference type="STRING" id="1365484.W6QXH3"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM34237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="96" mass="10973" checksum="04D5F4CEE4653BCA" modified="2014-04-16" version="1">MLIASYKNFYIASVDTVQTTLEARTTRVVRIVTRPRLGMTKRIVQAADRAYAIMHFPVCMLGPYGHSPPLGQYRTVIFVLEGIRLFHALPFIRHLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2024-10-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>W6QZR9</accession>
    <name>W6QZR9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S03</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S03g001789</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM35062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QZR9"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM35062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="70" mass="7501" checksum="52E72A7036F7EF50" modified="2014-04-16" version="1">MGIKICEVNFIHVFHLQNFTVNPVSIEAATACCGTVVPGTGPVCIDLSPLAASTSLWVRQFQNFEPLLPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W6R278</accession>
    <name>W6R278_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Amino acid/polyamine transporter I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PROQFM164_S04g000823</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6R278"/>
    <dbReference type="STRING" id="1365484.W6R278"/>
    <dbReference type="OMA" id="TSRHIMM"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000006">
        <property type="entry name" value="General amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF21">
        <property type="entry name" value="GENERAL AMINO ACID PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="76"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="190"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="238"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="279"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="377"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="408"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="453"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="485"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="9">
        <location>
            <begin position="49"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDM35942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="546" mass="58766" checksum="FB46E608A2C3F25E" modified="2014-04-16" version="1">MEKSGYDNENVQSAPGADFEDYDVNPKAEFELNVGGRAPLQRRLRNYQVTMIGFCGGIGTGLFVGTGAAYAKAGPAGLLLAYIIVGGVLWCVMQSIAELATLFPTAGSFPHWATRFIDPAVGFSLAISYGYCYTIAIASEVSAAAVIVSYWTDLTPAVVITVGLVLILAINLMSVRFYGETEVFGGAVKVLCFLGLVVVSIVITAGGAPKGGAIGFRYWHHPGPWTDYNGITGPTGHFLGFLSSLVNASFSFIGVETVVITASESVDPHRAIPKAARRVTYRIGIFYILGALLIGMIVDPRAQGLVSGTGNANSSPFVIAITNAGIKALPSIVNACILIAAWSAGNSYCWVGSRMIVAMTTDKQLPQIFARVNKSGVPYYAVFAAWLFGPLAYLSLGTGGAAQAFTWLLNLSTIAGLIAWATLCLCYIRFFAAMKKQGVSRDTLPWQAPLQPYAAWVGFIGSIIITLVAGFPVFLKGNWNTSDFIASYIGIPIFIFPIICWKIWRRTKFERAASIDLWSGRLVDGEITHVENPNRNALTKFTDWLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W6R3D8</accession>
    <name>W6R3D8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATPase, F0 complex, subunit F, mitochondria, fungi</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S05g000140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019727">
        <property type="entry name" value="ATP_synth_F0_fsu_mt_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28161">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT F, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28161:SF1">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT F, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10791">
        <property type="entry name" value="F1F0-ATPsyn_F"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM36307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="149" mass="16738" checksum="7107703200C8A9D8" modified="2014-04-16" version="1">MTGRSRHHRIGFSRAWQAEHPQGSVCSSFLLHQLSLVHLRRESILDKMSYIARRGLSTLIPPKVASPNAIGAAQDAARMERVVTFYAGLPRGPAADVKPTGLIRRYQARYFNGKNASGLPFVHAIAGILIMGYGMEYYFHLRHHKNHPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W6PRG3</accession>
    <name>W6PRG3_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Nitrogen fixation negative regulator NifL</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PROQFM164_S01g000140</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PRG3"/>
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    <dbReference type="OMA" id="DEYHEWV"/>
    <dbReference type="OrthoDB" id="447251at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47429:SF9">
        <property type="entry name" value="PAS DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47429">
        <property type="entry name" value="PROTEIN TWIN LOV 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0157">Chromophore</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAC" evidence="4">
        <location>
            <begin position="363"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDM26331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="611" mass="69242" checksum="CA32A11020210FFF" modified="2014-04-16" version="1">MKPWRVHEMMYHSGGAPVPREGFPTIKEKVYLRGLQGLHDGLRTPDAESLRSFTETIQDEYHEWVSESGRLSQTDQLLDNFPHPPRLESLNAIHEEEMEAYPTPNPSIKNLRRHATANELPLLQQINPNEGAPEFNPVSEETGSYDLIAPYDGGDLPLYKLERIADIMFSSEHMLTILNNPRYLARFRDFILEERPRSISTLTYYLNASKALKAIEYANALVRLSIDVPPPAVRTDGEAAGVTVNRVLERRVVDGLLALTAEELPAFITARCINITSKIVEERVRGTLPMKFRGTSNALAEVFCLTDPSRPDNPIIFASEEFHRTTQYGMDYVLGRNCRFLQGPKTNANSVRRLREAINAGRHHSEMFLNYRRDGSPFMNLLQCAPLCDSHGRVKYFIGAQIDVSGLAMEGASMESLMELQNKYRDPDEESIAEPPEAEEKDEFRELTELFSPRELSAVQQYGGNLFQPMQSLAYPHHPRSWFQPDASLERETEAVRLREMKSPLFRMSFAGVYENYLLVRPYPSLRILFTSPALQIPGMLQSPFLSRIGSSSAVKDDLLQTMKVGRSVTARIKWTTRSNPDGRNRWVHCTPLLASNGQVGVWMVVVVDDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W6PT40</accession>
    <name>W6PT40_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Nuclear cap-binding protein subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">20 kDa nuclear cap-binding protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">cbc2</name>
        <name evidence="11" type="ORF">PROQFM164_S01g000854</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the RRM NCBP2 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PT40"/>
    <dbReference type="STRING" id="1365484.W6PT40"/>
    <dbReference type="OMA" id="DIRRIIM"/>
    <dbReference type="OrthoDB" id="201398at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005846">
        <property type="term" value="C:nuclear cap binding complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000339">
        <property type="term" value="F:RNA cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12240">
        <property type="entry name" value="RRM_NCBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000399">
        <property type="entry name" value="Nuclear cap-binding protein subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027157">
        <property type="entry name" value="NCBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034148">
        <property type="entry name" value="NCBP2_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18847">
        <property type="entry name" value="20 KD NUCLEAR CAP BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18847:SF0">
        <property type="entry name" value="NUCLEAR CAP-BINDING PROTEIN SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5 8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="10">
        <location>
            <begin position="50"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="23"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="131"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="144"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDM27045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="178" mass="20826" checksum="ED8A97F4148D3E92" modified="2014-04-16" version="1">MSLLAVNTVDRLDRPSAYYVSKNKRRRYNDREEEEPQQQEKPDDKLKNATTLYVGNLSFYTTEEQIHELFAKCGEIKRLVMGLDRFNKTPCGFCFVEYYTHQDALDCLKYIGGTKLDERIIRTDLDPGFEEGRQFGRGKSGGQVRDEYREEYDPGRGGYGRAYDEQRQREEDEYGAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W6PTG2</accession>
    <name>W6PTG2_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S01g000860</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PTG2"/>
    <dbReference type="STRING" id="1365484.W6PTG2"/>
    <dbReference type="OMA" id="GVAHARY"/>
    <dbReference type="OrthoDB" id="3260408at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23242">
        <property type="entry name" value="TRANSCRIPTION FACTOR HOXA13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23242:SF9">
        <property type="entry name" value="TRANSCRIPTION FACTOR HOXA13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="557"/>
            <end position="597"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM27051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="1265" mass="136226" checksum="2F23593752478DBE" modified="2014-04-16" version="1">MVVKGNEVTDVTTKAKGRMDLEKPRRKGFVRWTIGLIVRLCIWYALLTPFFRCPTHLEDLTETSPRVCKPYLIARSHVEPYVTPYYDIYAAPYVDQARPYVKVFNQRVYTPASKFTKSGYEKYGAPTLKQAQAYGIEQWEHQVSPRLRTAQNKVHQVYLAKIDPHVQQSVDVVSPYCQWASTVVLNVYQGQLVPFYARSKPFIGKVYSTGQGILATHVMPGAQYTWSSAIYFANSSLWPHVTGLYSEQVEPQLVKIGQRLASYREGKRLRAVIEDVDSSSTVQPVSSLTTKSQEQIHTSTTMTSTFTPQASVQPTLTPTEQAQQVREEIDSDLWRWQERFSLAADKGIEDLEGRIGEIVSALVASSANTHGQSLSTALQSVSAEQISSMKQRINELAGSMPEVDAPEIEKSTSDLLIREIRTSAISVRDRAHALREWSISFEDELVRRVTAAVNSTIDVLDSIRNLGLQEIGMRWAWMDGVTYKDWAKYHALKAQLEEWRNDIRNVGMNHKSVSDARAVASDILDQGMHEAEQAARELVRLKDVGIWKIAAREVSDHFETRTEAPPTRPKAQEETEESDEEAAKMDFGNDESSEEVATPISDDAYEETPFTDEPSAAVNAEADFDGVNESVMDDDIVVENQPSARPAFGVAAADANLHQAPILDDESHNVQDSLASKVGDTYAGASDAVSEAVYGASTTNGVGEKVASLASEQYSVAWSAASTVIHGTPLSPVEKVYSDGSEKYSDAVAAASSVIYGTPTPVVQSLMDGASSTFADSTHQAKVLYEIAKSQVLSRIAESSAPVHVQILASIESAYSGSLKYATDELESKLRSVRATPTPSNVGPLAHISSIASSRLSHGLSLASEQLARVQPPATTASIPQGGLEPFVLDAQRRYYEAVGLAHDHYSVFVSTASEAVYGSPTPTPAGSSKGIIEEAGSQYEHVSSLVSASLAAVVASASSVMSSADGGKAQSIVEDASSRYNAALSAASSSLSVASISASSVIHGTSTGPVESLYSQVPEKWESLISKASEQIYGAPTPFLQQVVNNGRPQFEAVQGLVSELIAGKQPSYTESVLSKLRAAYETPYPAVAFSSASSYVNEAYGSASSVAASVISEAPSVEDIIQHANNQLRAAVETASVGIYGTPKGSYEKATDAAADAYSTASAQIISAVYGKESSYLDVAKDAIENIQSTASAAIYGKEPSAVESAAIRLARAKKDAMSQLADLAANLPASNVIFEAVETATAHLKDTTSSIKSSAVSVKDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W6PTM4</accession>
    <name>W6PTM4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glycoside hydrolase, family 31</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PROQFM164_S01g000930</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PTM4"/>
    <dbReference type="STRING" id="1365484.W6PTM4"/>
    <dbReference type="OMA" id="HQGEWSF"/>
    <dbReference type="OrthoDB" id="10070917at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14752">
        <property type="entry name" value="GH31_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06591">
        <property type="entry name" value="GH31_xylosidase_XylS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1760">
        <property type="entry name" value="glycosyl hydrolase (family 31)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048395">
        <property type="entry name" value="Glyco_hydro_31_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025887">
        <property type="entry name" value="Glyco_hydro_31_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051816">
        <property type="entry name" value="Glycosyl_Hydrolase_31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43863">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G03140)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43863:SF2">
        <property type="entry name" value="MALTASE-GLUCOAMYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13802">
        <property type="entry name" value="Gal_mutarotas_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21365">
        <property type="entry name" value="Glyco_hydro_31_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 31 N-terminal" evidence="4">
        <location>
            <begin position="23"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 31 TIM barrel" evidence="3">
        <location>
            <begin position="232"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 31 C-terminal" evidence="5">
        <location>
            <begin position="571"/>
            <end position="655"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF21365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDM27121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="655" mass="75503" checksum="FC517B79EFA99E8F" modified="2014-04-16" version="1">MLYTEDDKLIFRFDDHILWVQPWGENAFRVRATRQASIPMEDWALSSKPPSPNLSIEISTDQEATITNGKIKATVSRRGKIIVYDSKGNKLLEEYARHRLDPMDPKCSALTIEAREMRPILGGDYHLTMRFESLDRKEKIFGMGQYQQPYLNLKGTDLELAHRNSQASVPFAVSSLGYGFLWNNPGIGRAVLGTNIMSFEAYSTKALDYWVVSGDTPAEIEEAYAKVTGYVPMMPEYGLGFWQCKLRYTNQEQLLEIAREYRRREVPLDLIVIDFFHWKHQGEWSFDPEFWPDPEAMVKELKELKVELMVSIWPTVENASENFPEMLEQGLLIRHDRGMRVAMQCDGDITHFDATNPAARKFIWSQAKQNYYNIGIKTFWLDEAEPEYSIYDFDIYRYHAGSNLQVGNTYPKEYARGFYEGMTAEGQTNIVNLLRCAWAGSQKYGALVWSGDIASSWSSFRNQLAAGLNMGLAGIPWWTTDIGGFHGGNPKDPAFRELFTRWFQWGAFCPVMRLHGDREPKPEGRPTASGADNEIWSYGDEVYEICKRYIGIREQLREYTRGLMREAHEKGTPVMRTLFYEFPSDEPAWEVETQYMFGSKYLVVPVFEPGQRKVKVYLPAGASWKLWDGKDTVYEGGRDVEIECPIQSMPVFCRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W6PTQ3</accession>
    <name>W6PTQ3_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Pre-mRNA-splicing factor CWC22</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Pre-mRNA-splicing factor cwc22</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">cwc22</name>
        <name evidence="12" type="ORF">PROQFM164_S01g000965</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM164</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CWC22 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PTQ3"/>
    <dbReference type="STRING" id="1365484.W6PTQ3"/>
    <dbReference type="OMA" id="ILTEDMR"/>
    <dbReference type="OrthoDB" id="3938623at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000004">
        <property type="entry name" value="pre-mRNA-splicing factor CWC22 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050781">
        <property type="entry name" value="CWC22_splicing_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003891">
        <property type="entry name" value="Initiation_fac_eIF4g_MI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003890">
        <property type="entry name" value="MIF4G-like_typ-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18034">
        <property type="entry name" value="CELL CYCLE CONTROL PROTEIN CWF22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18034:SF3">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR CWC22 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02847">
        <property type="entry name" value="MA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00544">
        <property type="entry name" value="MA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00543">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51366">
        <property type="entry name" value="MI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="MI" evidence="11">
        <location>
            <begin position="426"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="384"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="622"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="56"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="387"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="650"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="688"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="740"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="776"/>
            <end position="803"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00040804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00069506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDM27156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="810" mass="92264" checksum="D9AE8A87524DC267" modified="2014-04-16" version="1">MSDLDVLQSAVRVPTPPPGASYSPAAASRKRSPPSRSPPPNRRRSPPGDSLQDGSDVLKADAEYADDRERQLTERVREHEKREAARKPMTEEQKQASAKAEYEKLLTMRSGGTYIPPARLRALQAQITDKTSKEYQRMAWEALKKSINGLINKINVSNIKFIVPELFAENLVRGRGLFCRSIMKAQAASLPFTPIYAAMASIVNTKLPQVGDLLLARLIVQFRKAFKRNDKAVCISSTTFIAHLCNQQVAHEMLAAQILLLLLHKPTDDSVEIAVGLTREVGQHLEEMNAPIALAVFDQFRNILHEADIDKRVQYMIEVLFQVRKDRYKDNPAIKEELDLVEEEDQITHRAGLDDELETQDTLNIFKYDTEWEEHEEAYKKLKAEILGEDSDEENEDRSDESEEEESDTEEVQMDIKDQSNTDLVNLRRTIYLTIMSSIDFEECCHKLMKINLPAGLEHELPSMIIECCSQERTYSKFYGLIGERFAKINRLWSDLFEAAFAKYYDTIHRYETNKLRNIAQFFGHLISNDAIGWHVLSVVHLNEEETTSSSRIFIKILFQNLAENLGLPGLQARFRDDILRPSFEGLFPTDNPRHTRFSVNYFTSIGMGVLTEDMRENLKTIPRPTVPALPTRAASRSPSHTPSDRSRSSRSSRSMCSTCTGSPHSRRSRSPSYSRSPSRDRGRSYSHSLTPSSRGHSYTPSRSRSPVHRRRDASDSRSPVRHRRRDASDSRSRAPAGRSRSRSISRTAAKRSRARSRSYSRSPSRSPYRSRRSVTRSVTPPRRGQSPPSRRNRSYSRSVSRSANTRTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W6PUX4</accession>
    <name>W6PUX4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Basic-leucine zipper domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S01g001844</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PUX4"/>
    <dbReference type="STRING" id="1365484.W6PUX4"/>
    <dbReference type="OMA" id="SMSYATM"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052635">
        <property type="entry name" value="Sec_Metab_Biosynth_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39607:SF1">
        <property type="entry name" value="B-ZIP TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39607">
        <property type="entry name" value="XANTHOCILLIN BIOSYNTHESIS CLUSTER TRANSCRIPTION FACTOR XANC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="2">
        <location>
            <begin position="42"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="19"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM28033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="285" mass="32029" checksum="8D89F9DD9B69552E" modified="2014-04-16" version="1">MNRSPSYDGRSGSRGSHLNSSAFSPNANPNEDWTKISDLAERRRIQNRIAQRNYRKKLKRRLEDLERRAATSASPEQSHAEPVSPPSPKTRTKPRSKVTDVKPHSQSDRAASYDYYSPEDRQTMFAQQCTRQLSASPPPVFSYPSMASYDTYRPSYAQPPIYHAAPSTYSEIAYQAEYGEQLPSLVPMLPSMQARKLAYDDDLISPFSMSYATMAGIDLCQQQAQAQAHSQHQSSALPMPALAYYDQRAPSTSPETSIFTFPLTPESGPCSPRSMHGLYEYDLRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W6PVD3</accession>
    <name>W6PVD3_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S01g002009</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PVD3"/>
    <dbReference type="STRING" id="1365484.W6PVD3"/>
    <dbReference type="OMA" id="VVEMRCQ"/>
    <dbReference type="OrthoDB" id="8300214at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM28198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="294" mass="32325" checksum="07F4E4B801B2DF74" modified="2014-04-16" version="1">MSSSQGKSSSSQYEPLSLQDDGEGSSATFEKRSSEDDHSTPLLEASDNLPALAPSKPSQLPKLILYFSFALALLSAVNVALLPTTLSKYQAYPFSDSDLEALPYGDARLGLDRVAKFIPPPKVYHHTWPDRIARVSRRLKNAVWGQGVQVYVTVEDSTIMRFPISPTGVNTCALSWRPPPEFSPRAKDLTTKGDITEIEVWQLIAPSDILANVSSTMDELDYDTLSYSTLPVRGELLGVLDLTAKPNSTTLEFACPRGAESLVVEMRCQRVACHVSFMQIHIAPSFGFELLERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W6PW54</accession>
    <name>W6PW54_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g001827</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PW54"/>
    <dbReference type="STRING" id="1365484.W6PW54"/>
    <dbReference type="OMA" id="YFYYALP"/>
    <dbReference type="OrthoDB" id="4218123at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39470:SF1">
        <property type="entry name" value="CHORISMATE SYNTHASE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39470">
        <property type="entry name" value="CHROMOSOME 10, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="228"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM28016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="377" mass="41518" checksum="9ABAB14D293510C7" modified="2014-04-16" version="1">MAPIAISWGTVKSVLIFFAPIILPRLITAYRSLRVSIASRPPPRPLPAAPGRALNILFGGIVFFLLLSLPFNPHAPEPNIFSQTRSRLNTPTDVIFNRLARLRPDNFLTEADNLLQSKFTSLGARKVYLTYGPDALVSCQYCSFDNIYTYLLYYLPFHVLLPHLAHLLLLGVATSAPIAGREASRWRIKFTLAGLVLAAVDIYIMATYDAVQSAPRSVRAGQTPPSGIYNHITLLRPLAFVICDVICSVVLWLSATNRFFFKPPSTVEQIDEAVSMAVQTLMGANSKLHAASVTRNAVVRDSTLKNRDDLYWRTMVASENPTQGPGEGGEQILNNIWEEEEVARAMSRAMAGHGGIDLAQLGVSANDFVRHVTEGLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2024-10-02" version="15" xmlns="https://uniprot.org/uniprot">
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    <name>W6PWB2_PENRF</name>
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        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
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        <name evidence="1" type="ORF">PROQFM164_S01g001887</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PWB2"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM28076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="125" mass="14097" checksum="9A92534E88F8011C" modified="2014-04-16" version="1">MYWTLGGHEFPDWVQLRVPLSTDDSTSSRVHTNLRVVGYGDLHPPCIPWDSSSGNESHDFRNIHEKARFDVGQQVLRVPLPTLSHGGYGEMVVRGMGRGEEEEEEKGVRGEGTLLYPSRMGLWAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W6PXI8</accession>
    <name>W6PXI8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RNA polymerase I specific transcription initiation factor, RRN9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S01g000483</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Rrn9_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059095">
        <property type="entry name" value="Znf_C2H2_17_2nd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10680">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26176">
        <property type="entry name" value="zf_C2H2_17_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rrn9" evidence="2">
        <location>
            <begin position="165"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-domain containing protein second zinc finger" evidence="3">
        <location>
            <begin position="606"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="348"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="501"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="351"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="367"/>
            <end position="383"/>
        </location>
    </feature>
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        <location>
            <begin position="414"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="503"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF26176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM26674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="654" mass="73595" checksum="765D41E2C3B04D38" modified="2014-04-16" version="1">MSSLYGSQSTWPENIPPQSAQPHRSLFGGPSSDVLQPSSQLEPPRSSLFGGGPIEQDAPLEPFSEADLMDEELDQNENEIDVIMQEQPLALQNDSDDESQGNNRGRSRIHSKRAQESPLDPIYYVVDRGLDLPPGVERPNLFDGHATSWRNYNADDIGAYNAIVTNRTRDLAAHLYNAHVVRKRAQDTARENPGVDKVPLRVNKRWAAWPVHAATVPRANEIIQRVMDASDNFQMQPDPRPSAGLEECITAFILKTSKETFQAREWDSEEIKHNSRNKMNDGKELMEDELGKNEENEEARVDVRTLRPTVLLDDDTAIRQLRPLVRNVISQVDRLLYGLHCAMKGRKFEEESGEEQWSDSDGDHQTRHSRKLRSRSRSRGRRSARQESQKRNISRPSNSAHISTRPETKDENLPNVSHTRAQSRGFSTGHESSHHINGRLKLRDWSEVMGLASMIGLPSSAVMRASKRCADLFGEDMEFRIMPEGRVRKRKKVDAREEYAYTESASDSDSKPLSVQPIPRPVGQPTRKRKTDPGLGPKAQAKIPGQRRSKSHMTPAIVPSSSPAPEEPTESREAIAENTRRAIAQGSRTVKPGVGKGPHRKLDIVCHFRSCNRHTNGFSRKWNLNQHLKKAHGINVAPGNERSIERDATVIVLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W6PZ71</accession>
    <name>W6PZ71_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S01g003380</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PZ71"/>
    <dbReference type="STRING" id="1365484.W6PZ71"/>
    <dbReference type="OrthoDB" id="5273847at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM29568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="150" mass="16490" checksum="9748D2F5A7374557" modified="2014-04-16" version="1">MLGRVFELKPPSFQQCARGAGFRAAARALPATNGSYILQLIYPSDMPNNILGYRAPGNQTMIGFEGRPLRGFEVIIGIGAFRAIRPLFNPMNNWFGRPTNNSEELECEFEYMQISTDDEILALSVDFDVSLVCSASCACHSNSNVSITNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W6PZD4</accession>
    <name>W6PZD4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g002902</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PZD4"/>
    <dbReference type="STRING" id="1365484.W6PZD4"/>
    <dbReference type="OMA" id="SERWWTV"/>
    <dbReference type="OrthoDB" id="4227485at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022198">
        <property type="entry name" value="DUF3723"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12520">
        <property type="entry name" value="DUF3723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="593"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="741"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="847"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="966"/>
            <end position="1094"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="624"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="640"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="766"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="847"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="896"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1025"/>
            <end position="1036"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM29091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="1207" mass="134815" checksum="FAB1BD6628C835DD" modified="2014-04-16" version="1">MEQSMFTDAEAQLTTERRLKYQGTAKIDLSQITCHPCVARQLDQKNVERLCEVFRKDGCNRLDVQHHVTAVVTRRHLKHARREAQITAEELLTNRPDKYPFLSFPSSQIQCLHGQHRLHAATEVLAPSERWWTVDLYLDDISHELRNTLVDEYANEKTPTDGDIYRKIRQYQSEHNAAFQKRWWTRLSENKAKRLRQLMSPDNVDICAAFDALLPIPGLWNGLSIGSLNRVLALKCDEEIIHYLQHVERFWSTLMDGDRHQMAKIDIHTVEKLQLRAPAACSADAREVKGYILGGEVFSQFEETEQPRIWDRMSSYDGIIPSIHTFFRDTTYLEACATGVRQFAVLSKSQPTVRAALKHAYKPDTTRGACLVQTSDASFRNHTGPSTDSFELAYRQIWLFAMRHYPEMAKDATSKKVVAKTIRGRADEVVLHNMATLAQKLGFDSLPVTEMLNRSPDRRIAREALLKARKPGSYRYDPATFDSLIDRLVECFGTAVAHEALPSPDFVLERTPTLSRRCGPPLEHVQPIDRPHLFLGKVHSKEATGPQTISSFFVRQCVYFAFFDKPLTWTQSQDHDQASPELLQTDVSRSPLFVPVDDLPSNPRVVPATGSASQRQSRREQRQERRRRRQATGNRSHRDRRQEIVEEIHPAVPADPVDSITADDDMGMNDVAHVVAGGADISMAGSSSESPIGGSDHLAIQNELFRDTRRDVEENPELLPNVEQDEQALAQVSDTRRNLGDIVHEPSTDSPNGHDTAERQSEVNEDTASQYSQDSSRSGENDSMEYVESVVPAEMQDRLTRGVSSDADLQLTSCPVEADSESLNQRTEEREVAQDAVQQALRMLEQEAETRAHTSIERSEEQFATSTDEPTASLELPSPGVGPAVNALAESRISNEHSPATTQNPDPIVRQGRVPRNARAAKTITQIDLTGLDAAIIVGEDGPDQQEQAESPIIGRAAISTPLGHQELSEHEQGTDNMGPREFLSDLPDPSASNPIIGESTGPPRPAALQISAGATGEGGPSQREQADVQITHHDMASPVSKPPEPKEHVRQTNKKKLRENKDDSQEAPASGQNISEFTVPPLPEALRPRRNPPPNAITITFKIYENGGWHVTDQVPVSPKDPSEAHRIAHKYARKDNKHARFYNKNLRLVSAAQCVRAAMDDGSNTVLMSLQQDLVVTRAKVAAVAEMMEADAQRRAATDADDIIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W6PZE7</accession>
    <name>W6PZE7_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g003445</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PZE7"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM29633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="97" mass="10532" checksum="1CB3E908626DAEB0" modified="2014-04-16" version="1">MSTFSFTRTPYPVARQNARWASPLKSPWEFNYDSSCGRQAKICRGPDCNCADLKPPSPLTGHPHSPVTSSENGDQSIGGTTDDIAPKVHQSLCTCGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q0A6</accession>
    <name>W6Q0A6_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g003193</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q0A6"/>
    <dbReference type="STRING" id="1365484.W6Q0A6"/>
    <dbReference type="OrthoDB" id="5392447at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM29381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="117" mass="13188" checksum="46F777787700C821" modified="2014-04-16" version="1">MNTTIREENCKSVDLDGFGSTADDAWFDYHTAPMDGEEETGAHPHQVAAFKAYMKGDSTPSETAAIMTKPHDPDERTDIQRRHTTPRTGHNRRRAFSAALKPHARPHRLDKGNYQGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q0W3</accession>
    <name>W6Q0W3_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S02g000094</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM29945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q0W3"/>
    <dbReference type="STRING" id="1365484.W6Q0W3"/>
    <dbReference type="OMA" id="YANNCKG"/>
    <dbReference type="OrthoDB" id="3672617at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029167">
        <property type="entry name" value="Mug117"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15474">
        <property type="entry name" value="MU117"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004879524" evidence="1">
        <location>
            <begin position="20"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM29945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="116" mass="12038" checksum="6C8B3358FACDCF42" modified="2014-04-16" version="1">MHASKILATFVAMGVHVVAYNNNCEGSGAAGIALIPQNCINAKNAIDTSATYTDGTEFSKGNCYVKYATNGSGDQPISGQDIVNTMTTIMDSCDVGIGSFGTGNCDSCHVTINYRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2024-10-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q0X4</accession>
    <name>W6Q0X4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S02g000347</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q0X4"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM30198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="69" mass="7325" checksum="A9B128CC65D3C92B" modified="2014-04-16" version="1">MRSGDSTQHRSAEKSSSAPRPGAPSCNVRDTDLVNTVIEDIATGAVYIDDLGSRGSRNPGVERYTTAMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q107</accession>
    <name>W6Q107_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S01g001700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q107"/>
    <dbReference type="STRING" id="1365484.W6Q107"/>
    <dbReference type="OMA" id="VYMPSMA"/>
    <dbReference type="OrthoDB" id="3993201at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM27889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="214" mass="22931" checksum="6687AAD1696A2C51" modified="2014-04-16" version="1">MIAPRSSSLRAVRALSQQPVASAARRSLHITGVQAAQPVNPGEKALSNHDVLQSRAFSIAMRRINGNAFSDPSSRQFNTSRASKATHDNSTVDFVYMPSMAELDAAPLQRPIQVPVLSGPSTRLQTPSPPSMKPQIYTVSGGAGPDVQASAMSEVVDNHAVDFDPFSLTEAVGRSRAGEELQRKENGTSEPGVIRELWAGFVDDVLGPKQSVRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q1U5</accession>
    <name>W6Q1U5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S02g000667</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q1U5"/>
    <dbReference type="STRING" id="1365484.W6Q1U5"/>
    <dbReference type="OMA" id="GWLIWRV"/>
    <dbReference type="OrthoDB" id="5421757at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="73"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="13"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM30518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="356" mass="40422" checksum="7769629092561445" modified="2014-04-16" version="1">MAKSSRRSGRGKTPSSSGASTPSSASSGPIPPFTKVPQALQPFVEQLSPDEVYLVHIDTTAEELKRQTFTVPLIVNLIVTAILGLRVYMGISTYPALVGTLIGLKNSMTVDTSTPWPEAVRIILWRTGNICVDYFLVSLLWSWPVNFVRGPLHWRRAIGFLEREIIVRRSNRSWSKELERNRWIRDDEARRDKIVAAVTPERIAKTGYLLVDEDWNLDYAAMVRAHGLVERTRRTDGVKMDEFRTAVLVNTDADGWLIWRVGDDNTPTSQKDSVQRDQLLAFKDKLADMGKEDLFLRWVELIQWESSRPGGFTVERQRSAMMQAKQMFEDENVDFSQFWHDMGGMEGVEGLDPGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q219</accession>
    <name>W6Q219_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Meiotic recombination protein rec14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rec14</name>
        <name evidence="4" type="ORF">PROQFM164_S02g000185</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q219"/>
    <dbReference type="STRING" id="1365484.W6Q219"/>
    <dbReference type="OMA" id="LDSSMCL"/>
    <dbReference type="OrthoDB" id="10251741at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051510">
        <property type="entry name" value="SKI8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44090:SF1">
        <property type="entry name" value="SUPERKILLER COMPLEX PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44090">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="186"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="228"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM30036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="309" mass="32947" checksum="F96EA8055C02F51F" modified="2014-04-16" version="1">MSKQYLSRGSADNAHIIDIFSLAITDKQILSTSGASSIKVHSTIDADFPLVQSIDGAHTIGCHHIVTNGNGSRAITAGFDGEIKVWSCQDGHWAADTKLTADLTNADAWAIAISEDGQYLAGVTQEGRINVWDLAADGTRIRDHETKGSFGTCIDLSPDGRLIASGHEDGAVYIFTTETGRMPFSLSGLVNPVRAVAFSPKSKILAAAGDSKVIVLYDTSSGEQIANLSGHSAWILSLSWSDTGEYLLSSSFDGKVKVWSMETKTCVATHSETDKAVWNAKWLPKIGKTEGFATAGANRSIAFYREATG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q330</accession>
    <name>W6Q330_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD-dependent pyridine nucleotide-disulphide oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S02g000525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q330"/>
    <dbReference type="STRING" id="1365484.W6Q330"/>
    <dbReference type="OMA" id="GAAMHQG"/>
    <dbReference type="OrthoDB" id="202203at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004174">
        <property type="term" value="F:electron-transferring-flavoprotein dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43735">
        <property type="entry name" value="APOPTOSIS-INDUCING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43735:SF24">
        <property type="entry name" value="NUCLEOTIDE-DISULPHIDE OXIDOREDUCTASE AMID-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17180)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="1">
        <location>
            <begin position="10"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM30376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="416" mass="45572" checksum="671DB5A64B81F820" modified="2014-04-16" version="1">MPSLEEQPPFKVLIVGGSYSGLAATLNLVDLCHGRKCRFSLDENDQGPGNTIPVQVTIVDERDGYYHLIGLPLAIASNADASTFWKKFEDIPALQSPDINHIQGRVDSIDCKSRIARIHQNTANDGHKIVEEKYDYMIACSGLRREWPSAPKSLTREAYLAETADSVQTIEKAAEGVVIIGGGAVGIEIAAEIKMLQPQAKVTLVHSRQQLLSSEDLPDDFKAKALEMLKESKVEVVLGARVQDTVLGSESSPAKYTLKLSDGRELVADHVINAVSRFTPTSSYLPKDACDPEGYVQITPGLQFSADVPNKKYHYAAGDIASWSGIKRGGAAMHQAHFAAVNIHQQMLAERYNTEPKFVELVEVAPMMALALGKTAVGYFPAMGLSSGDEVRNMFFNDDLGYEICWKWMRLGEATE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q3J9</accession>
    <name>W6Q3J9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type DNA-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PROQFM164_S01g002530</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q3J9"/>
    <dbReference type="STRING" id="1365484.W6Q3J9"/>
    <dbReference type="OMA" id="FDFLPMM"/>
    <dbReference type="OrthoDB" id="4454541at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF38">
        <property type="entry name" value="TRANSCRIPTION FACTOR, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G00410)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="22"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="53"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="114"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM28719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="698" mass="78458" checksum="2F545816C006F624" modified="2014-04-16" version="1">MSERGSEIVYRAENVPIRFFKACRWCRRQKMRCDARSQVPCFRCRSTGRDCILDPIDDGRRRNDRRRKTTTPARSTASPLDPRTGYHTPVTRDQGFSPATVQDGGFTTPIDSLPDSTGLGSLQRSYTSDTNGPESQQLSPNEMIAPASAVHSMSVNLLDTNDIFMESSVKGDPRGDVVARGIVSEELARVMYERFTGGSKNFLPLFDPIRDTFDSVRSRSLFCFTVIIYLASRAVTDLRGDTHMQRVLQDEAQRLAEDSFFERPTKLETVQGMILLAAYSEKTWFSIALILRTALDSGLEKSLDTLLSQENIPRSSLSASMADRELVWKTRTWLITFILELDVASGTGRKSRIAEVDVVKLRRFLDYPLSLPFDMRTVCIIELHQLRGNSRVVIDNTSTVSDIVSTELPAIMTRLQNWWTTWDEIHENNGFHIGAFQRSSLKLMLLYARIFVFCASLARIQKLQPTCTDSNSEILDQDVMNLWQSLVTTIMDQLNFLINEPSYRCQLPWAPTYPALTIAFVTTFPLRIARWRPNLINQTLLLERAEKICDFLKQPPYPDIHRTVSIFVNYARALIASQCPQNNNSTDVPIVSGQSEGPPFQGADNPMINGPPPSGVGPLEDLRYRTGPTIQADKVSNMVSMPSSDPSAVARAPVSRLSGTMEAPNWTVSNSIADSFGLFEEGQNDIFDFLPMMPSIPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q424</accession>
    <name>W6Q424_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL4m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PROQFM164_S01g002695</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL4 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q424"/>
    <dbReference type="STRING" id="1365484.W6Q424"/>
    <dbReference type="OMA" id="KTFGPHP"/>
    <dbReference type="OrthoDB" id="275876at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002136">
        <property type="entry name" value="Ribosomal_uL4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013005">
        <property type="entry name" value="Ribosomal_uL4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023574">
        <property type="entry name" value="Ribosomal_uL4_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03953">
        <property type="entry name" value="rplD_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10746">
        <property type="entry name" value="50S RIBOSOMAL PROTEIN L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10746:SF6">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL4M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00573">
        <property type="entry name" value="Ribosomal_L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52166">
        <property type="entry name" value="Ribosomal protein L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="131"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDM28884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="311" mass="34873" checksum="B2906E39440820E5" modified="2014-04-16" version="1">MPGNDVIRSLRLLSRSSGGLMSGPKQVTQRCLTRSMATEATTQPPVATKDAVQVQQAQRPGGPTPVQVMTYRWPNLEPQRLVHYSRRLLQMPTRHDILHRAVVYEGDSTRQGSASTKWRDDVHGSHRKLYAQKGSGRARAGDKMSPVRRGGGVAFGPHPRDFSTDLPRKIYDQAWRIALSHRLSRGELIVVDNSIDINENASPFFIINLIKAHGWYQKGRSTFVTLKPNEMFSDAVEKFGNHARTISVEDLDVKNVLETARLIIEKNALHKILLSHSTDLAKVDTLFSPSANGEKVYPLDFSRMKATWSNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2024-10-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q4B2</accession>
    <name>W6Q4B2_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g002815</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q4B2"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM29004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="98" mass="10622" checksum="5B989BC5F49AD58A" modified="2014-04-16" version="1">MKEAWLATEKKKVWENDEPFSPADEWSESVLCLGRPTDESSREAFSAPASLRLDSSSVPVRVSGGATKFTETKGSGRKASKRAGQPSFMSPYLQVAPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q4F8</accession>
    <name>W6Q4F8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S02g000971</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q4F8"/>
    <dbReference type="OMA" id="QEIRDWG"/>
    <dbReference type="OrthoDB" id="3016366at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM30821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="172" mass="19438" checksum="D32C8948FEEAC3E2" modified="2014-04-16" version="1">MSLADLQVGGLYVILQAHHEPPEPNEFYWGLYLHSDPVGGMAYHVIDTGSGLRPEHEYTGRIFDTPLLTGLFRIADITRPLHPFVDRVVRSYDSSLNCPGRSSNSKFWVLNVLALLIQPTATGWLPVNCHNLPILEQEIRDWGNRMSQGRCIYQRLKPIGSSTICGLPEWKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2024-10-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q4X0</accession>
    <name>W6Q4X0_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S02g001166</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q4X0"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM31016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="64" mass="7069" checksum="5DCFDAD666582382" modified="2014-04-16" version="1">MYRPHIDLAEEPGGRSIAVESSHSCNLCAKGILPWSQIELEYCCSGSFRGWAECPTSNLDLHCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q5X6</accession>
    <name>W6Q5X6_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PROQFM164_S01g003461</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q5X6"/>
    <dbReference type="STRING" id="1365484.W6Q5X6"/>
    <dbReference type="OMA" id="CHNDFGA"/>
    <dbReference type="OrthoDB" id="5979581at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050684">
        <property type="term" value="P:regulation of mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Serine/threonine-protein kinase, putative (AFU_orthologue AFUA_6G02242)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051334">
        <property type="entry name" value="SRPK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634:SF9">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="5 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="60"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDM29649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="455" mass="52406" checksum="C8AA686C7A5A4498" modified="2014-04-16" version="1">MNQLAKRTIFSLARKPIWHLPSRSALPIPQHEAVDEEICPGYSPNHFYSANPGDILASHYQLLVKIGWGTRSTVWLARDITRLRWQSERTVALKIINSCRDREPYHERDIEEHITRQNQSHRGRAIVRTCLESFEVASTEGNHLCLAYKPMREPLWILQRRFVDRRLPLPIVKAYIFFLLVGLDFLHSDCGVVHTDLKLDNILMSFENESVLSAFVKLQINEVPMQYKVDIMTGRTVYRCHNDFGALDWTNLKNMVPKIADFGLSTRLSYDSPRKEAGGDQTGIYPIQPDHYRAPEVILGCGWDSKADIWNFGVMMWNIIECTELFQQVHNTDGRYDSKSHLAEMIALLGPPPEKLIAKENAMAQHNWPHPISNEAGISCSNAREYFDGPFFSDEGKFLYDDLIPARSLEATLPSLEENERDSFLSFVRGMLTWLPEERKTARQLIAHPFLNIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2024-10-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q6G6</accession>
    <name>W6Q6G6_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S02g002086</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q6G6"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM31935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="42" mass="5178" checksum="BA434DAC85533439" modified="2014-04-16" version="1">MIRKFLYPAPPRLHLGPYVSMDVFMKTWTIFKRPRDNRSRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q7S1</accession>
    <name>W6Q7S1_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Mitochondrial carrier domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PROQFM164_S02g000423</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q7S1"/>
    <dbReference type="OMA" id="DIWIAGA"/>
    <dbReference type="OrthoDB" id="250329at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45667">
        <property type="entry name" value="S-ADENOSYLMETHIONINE MITOCHONDRIAL CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="3"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="123"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="236"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="273"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="273"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDM30274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="361" mass="39932" checksum="7F5BE97899A2F65C" modified="2014-04-16" version="1">MYNTHSDIWVAGAFAALIVDFIAYPFDTLKTRVQSPDYEKVFKNARTGAVRRNVLFRGLYQGVWSVVFTTIPASGAFFTTYEAVKSIMYNSSKEASTSMNGGKRSSPDGSLNSLRLPFTHSLPTPIMNAIASSAGEMVSCLIITPAEVLKQNAQMVQGSHADKSAMRQVIWRFQHHPWRLWSGYTALLARNLPNTALQFPLFEYVRSHLINRRRRLKATRMNTGQPPSEIKDQLVERAGLTGIAAAISGTIAATVTTPIDVIKTRLMLSASDAASSQHKSTQAGTRGNEAISSDVRKKTKPGKTLISVGRDIIRYEGVRGLFKGGLIRAGWTAIALGLYLSLYEGARFYLENRRKEREHVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q7V4</accession>
    <name>W6Q7V4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S02g002242</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q7V4"/>
    <dbReference type="OrthoDB" id="10513783at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM32091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="168" mass="19077" checksum="97715CC84FBDA98F" modified="2014-04-16" version="1">MTSRFSQSPQCFEEANPHVACTNNNRDHILLALLQRELDPDKKIGELGSGVFSLSCQVDGFLESKSTFRAQSILEAKALRQLIHEPNVYWQETKWLALLNAHPEKSLPKDRTWVSGTEGTRQPHLPGLRCTFLKRNTYLIIKKEDAPYFAKLALAVALRTSKEGDERI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q7Z4</accession>
    <name>W6Q7Z4_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">U4/U6 snRNA-associated-splicing factor PRP24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PROQFM164_S02g002272</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Functions as a recycling factor of the spliceosome, a machinery that forms on each precursor-messenger RNA (pre-mRNA) and catalyzes the removal of introns. Chaperones the re-annealing of U4 and U6 snRNAs (small nuclear RNAs) released from previous rounds of splicing, an initial step in reforming the U4/U6-U5 tri-snRNP (small nuclear ribonucleoprotein) that can reassemble into another spliceosome complex; this step involves binding U6 and facilitating the unwinding of the U6 internal stem loop, followed by base-pairing of U6 to U4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q7Z4"/>
    <dbReference type="STRING" id="1365484.W6Q7Z4"/>
    <dbReference type="OMA" id="LWARYIL"/>
    <dbReference type="OrthoDB" id="360390at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12299">
        <property type="entry name" value="RRM4_Prp24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000632">
        <property type="entry name" value="Pre-mRNA splicing factor (Prp24), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000633">
        <property type="entry name" value="Pre-mRNA splicing factor (Prp24), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000588">
        <property type="entry name" value="Pre-mRNA splicing factor (Prp24), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000365">
        <property type="entry name" value="U4/U6 snRNA-associated-splicing factor PRP24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050502">
        <property type="entry name" value="Euk_RNA-bind_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031766">
        <property type="entry name" value="RRM_occluded"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48025">
        <property type="entry name" value="OS02G0815200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48025:SF1">
        <property type="entry name" value="RRM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16842">
        <property type="entry name" value="RRM_occluded"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="819"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="894"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="985"/>
            <end position="1061"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="1096"/>
            <end position="1169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="756"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1194"/>
            <end position="1266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="80"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="756"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="781"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1222"/>
            <end position="1233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1236"/>
            <end position="1266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00093374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00093627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDM32121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="1266" mass="142681" checksum="3C1295BC75A6E7EE" modified="2014-04-16" version="1">MDISSLLSPDSNPKSGNSTPVPGPTSNNAPATSAGPSPHKAIERTRTGSRRKGKISSPLAQHVYVPSGESSPGLSGGNGTSPTEVHSRQPSTPGMDTLADLASMQHHQPQRPTPTSMLRSTESYEHQLSPSTIHPHVNSINHNTPTSRMSFELAMSDGRDGPAKRTYAATSLDPDAQRLATELFHQISLNPHTHDAHVQFIGLLHAGFVNHVYPPNNPDVHGDPRRYDLLNDLKTAREEMDKLFAMGEDLWAEWIQDESMLAQDVDGRIAVLELCQRSVVEEFGSTKLWNIYGEWVLYLYNSAHGKTSSQWTEEDRMIGREVFTWDSVVEVWQRGADATKWRINNSHLVWDRLLDLYAQDIAREPSQEKINHLHGLYSHRLQTPHATWEQTFQKFSSFISAYCNSKYEEIMCETVARAAEAKALFNAREEFELRLVKAQESGDRSLEWAVYSEYIHWELTRNRRKRGEFNFELVNAIYQRAVLHFPTDVSIWEDYVMFLIGESIHRHASTTTISTLDRATRHCPWSGNLWSQYLLSSERENQSFNKISSIKHKATSTGLLDAGGLEEVLKVHVTWCSYLRRRAFLSDSTDEDLDVAEVGIRSAIESVQELGEKKYGPAYQGDPLFRLERIYIRFLSESGSWDSARETFKGLVARRGNSYEFWLAYYEWELICWSKFVQGEATVDAARRTPNPSFATAVLKQAIKRTDLDWPDKIVQTYVTHCEDYEDSDELQLAVIETRKAMRAVTARREREALEAAAAQQQQQQQQQQQWEAAVQAVPSPEKRKREDEKDGMPQTKKVRNQEALAEAPAPPPRDRENATVIVSNLPKGTTENSLTKQIGTINTVKMLRRDEKSSEVAIIEFETKEDALAAITRDQKRFNDTDNIIDVQIGSETTLWITNYPPDAGEDYFRNLFGKYGEVLEIRMPSLKFDTSRRFCYLQMDTSSAAHHATELHGMRFENGTRLSVKISDPGQRTARSGPRYEGRDIYVANIAWDANEKDLKELFSKFGEIERVLLERKTNGASKGFGFVTFSTKDAANDAVAMNEHVFKSRPLRVEIATTDSRRGNQLVISRVASHPADHGARGLEVPVGDHAQRTLALMNVPDTVNQARIRTLVEPYGRLIAINLRPEHQGAIVEYVDIQDAGKAALALEGKEIIAGRPLHIGTVREMLNLQPEVKTDRGQSAKPERIMKKTNLQLTAPIRRPQQPGARKGGGLGMKRQIVSSGQKQSAATPASDKKDATPDGESKPKKSNDDFRAMLARKGPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q928</accession>
    <name>W6Q928_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S02g002657</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q928"/>
    <dbReference type="OMA" id="VAPRIYQ"/>
    <dbReference type="OrthoDB" id="9983368at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM32506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="146" mass="16798" checksum="CC31F8F31A2948A7" modified="2014-04-16" version="1">MSVGPDLDDDAVLKWLEAFHRASATLNTDQWLDEFMTDDVEMQYANNPVIKGSEVRQMFKAVLGQLDMMTHEIRYFDYVAPRIYQAATIRYLVKGDSLDTDQITIPGFAVFSIRRDDDGRVKCYRAETFLEPSALFQRMAEKSSQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q950</accession>
    <name>W6Q950_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Probable transposable element</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S02g003076</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q950"/>
    <dbReference type="STRING" id="1365484.W6Q950"/>
    <dbReference type="OrthoDB" id="4368291at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM32925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="111" mass="12473" checksum="DA10992C52EB2017" modified="2014-04-16" version="1">MVNGPTSFRSTSVKPYHRAPKQDTTEPVSQHDPPPPIVEAPQPRRRGRPRGSKNKTAVITTPGEPFEASDAKEIEDLFNQGVFRFEKYDPTSHGGERIFKSRMVREVKAVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2024-10-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q970</accession>
    <name>W6Q970_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S01g000091</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q970"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM26282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="34" mass="3823" checksum="FF5D5879322236D1" modified="2014-04-16" version="1">MKRDPTFGLANEALMKAKAYHQILCKFQPLGAMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q990</accession>
    <name>W6Q990_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Lipase, class 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PROQFM164_S02g000904</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM164</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2019-11" db="PDB data bank">
            <title>crystal structure of a FUNGAL LIPASES.</title>
            <authorList>
                <person name="Wang Y.H."/>
                <person name="Yuan H."/>
                <person name="Lan D.M."/>
                <person name="Liu X.H."/>
            </authorList>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.80 ANGSTROMS) OF 27-305</scope>
        <scope>DISULFIDE BONDS</scope>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PDB" id="6L7N">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.80 A"/>
        <property type="chains" value="A=27-305"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q990"/>
    <dbReference type="SMR" id="W6Q990"/>
    <dbReference type="STRING" id="1365484.W6Q990"/>
    <dbReference type="ESTHER" id="penrf-w6q990">
        <property type="family name" value="Lipase_3"/>
    </dbReference>
    <dbReference type="OMA" id="PEYWISS"/>
    <dbReference type="OrthoDB" id="426718at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051299">
        <property type="entry name" value="AB_hydrolase_lip/est"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005592">
        <property type="entry name" value="Mono/diacylglycerol_lipase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46640:SF1">
        <property type="entry name" value="FUNGAL LIPASE-LIKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46640">
        <property type="entry name" value="TRIACYLGLYCEROL LIPASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G06510)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03893">
        <property type="entry name" value="Lipase3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="8" id="KW-0002">3D-structure</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004881368" evidence="3">
        <location>
            <begin position="19"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="Mono-/di-acylglycerol lipase N-terminal" evidence="5">
        <location>
            <begin position="5"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="Fungal lipase-type" evidence="4">
        <location>
            <begin position="103"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="62"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="129"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDM30754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="8">
        <source>
            <dbReference type="PDB" id="6L7N"/>
        </source>
    </evidence>
    <sequence length="305" mass="32991" checksum="9C4172A23C64BFD2" modified="2014-04-16" version="1">MRFSLFTALSAAASLGHALPGQLQARDVSTSELNQFDFWVQYAAAAYYADDYTAQVGAKISCSKGNCPQVEEAGATVFYDFSNATITDTSGFIAVDHANEAVVLSFRGSYSVRNWVSDAIFVYTNPDLCDGCLADLGFWGSWVLVRDDIIKELKEAVSQNPGYELAVVGHSLGAAVATLAVADLRGKGYPSAKLYAYASPRVANVPLAKHITAQGNNYRFTHTDDPVPKLPLLAMGYVHISPEYWITSPNNVTVGASDIKVIDGDISFAGNTGTGLPSLEDFEAHKWYFMKTDAGKNDGRPFKRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q9Q8</accession>
    <name>W6Q9Q8_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">2'-phosphotransferase</fullName>
            <ecNumber evidence="3">2.7.1.160</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PROQFM164_S03g000097</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the last step of tRNA splicing, the transfer of the splice junction 2'-phosphate from ligated tRNA to NAD to produce ADP-ribose 1''-2'' cyclic phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>2'-phospho-[ligated tRNA] + NAD(+) = mature tRNA + ADP-alpha-D-ribose 1'',2''-cyclic phosphate + nicotinamide</text>
            <dbReference type="Rhea" id="RHEA:23324"/>
            <dbReference type="Rhea" id="RHEA-COMP:11106"/>
            <dbReference type="Rhea" id="RHEA-COMP:11107"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:76596"/>
            <dbReference type="ChEBI" id="CHEBI:82883"/>
            <dbReference type="ChEBI" id="CHEBI:85027"/>
            <dbReference type="EC" id="2.7.1.160"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the KptA/TPT1 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.160" evidence="3"/>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q9Q8"/>
    <dbReference type="STRING" id="1365484.W6Q9Q8"/>
    <dbReference type="OMA" id="HATWPKI"/>
    <dbReference type="OrthoDB" id="419694at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000215">
        <property type="term" value="F:tRNA 2'-phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006388">
        <property type="term" value="P:tRNA splicing, via endonucleolytic cleavage and ligation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.170.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.970">
        <property type="entry name" value="RNA 2'-phosphotransferase, Tpt1/KptA family, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002745">
        <property type="entry name" value="Ptrans_KptA/Tpt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042081">
        <property type="entry name" value="RNA_2'-PTrans_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042080">
        <property type="entry name" value="RNA_2'-PTrans_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12684">
        <property type="entry name" value="PUTATIVE PHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12684:SF2">
        <property type="entry name" value="TRNA 2'-PHOSPHOTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01885">
        <property type="entry name" value="PTS_2-RNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM33373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="341" mass="36799" checksum="8E595D5B05FE1767" modified="2014-04-16" version="1">MAHPKDNKDKRGRGHGQGQSRDVQVSKALSLLLRHAAEKEGLKMNAQGYASVPDVLNWRKLKSLKVTFPEILYAVSSSDKKRFALLHIPSARATKSRTQASTTLVTTPDAEHEAGAILGEDQATTSVLESALSEAQQTATDQALAVEDTDPSNFLIRATQGHSIKAVDAASFLEPLSLSDESKLPDTVVHGTFHATWPLILQSGGLRCMGRNHIHFATGPSLESVLAIHADAAGGKPKLDDSRVISGMRRDAQVLIYIDVRKALQAGVPLWRSENGVILSEGIPLVASGQAEKGEADKFVSLDFFDVVVERKVGLGKLWANGGALQELPETLTKRNPKARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W6QAK3</accession>
    <name>W6QAK3_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S03</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S03g000184</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QAK3"/>
    <dbReference type="STRING" id="1365484.W6QAK3"/>
    <dbReference type="OMA" id="IHYDRRY"/>
    <dbReference type="OrthoDB" id="3257538at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019171">
        <property type="term" value="F:(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.129.10:FF:000103">
        <property type="entry name" value="WGS project CABT00000000 data, contig 2.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052741">
        <property type="entry name" value="Mitochondrial_HTD2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28152">
        <property type="entry name" value="HYDROXYACYL-THIOESTER DEHYDRATASE TYPE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28152:SF2">
        <property type="entry name" value="N-TERMINAL OF MAOC-LIKE DEHYDRATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM33460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="359" mass="39282" checksum="8C8D000E0541738D" modified="2014-04-16" version="1">MSSNLSLLTHLRPRVLARTRPGAIRSFTIPQRLRSDASSVASAFLSRFQSLGPQTRTQTIDANQLQLLTLTLNRPTLFPGAPSLSNSAPAPQSAVPVPPGYHLAYFTPAFLESELGADGTDVSYNPDVPFTRRMWAGGEVLWPRVDGKPNLLRVGQQVQETTRVLSAEAKVVKKTGEDMIVVGVEKEFANEHGVSIIDRRNWVFRKALPVPSASTSSSALPSPTSHIATPNPTSFAISTEGNAHTRTLVQTPVSLFRFSALTFNPHKIHYSLPWARDVEGHKDIVVHGPLNLICILDLWRDTRQNVTDSTLVVPERISYRATSPLYAGDEYRIVLEDGEGTEVQIIGPGGVVAMKAEIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W6QAW4</accession>
    <name>W6QAW4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SutA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PROQFM164_S02g001414</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QAW4"/>
    <dbReference type="STRING" id="1365484.W6QAW4"/>
    <dbReference type="OMA" id="IHNRWTK"/>
    <dbReference type="OrthoDB" id="288203at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008271">
        <property type="term" value="F:secondary active sulfate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07042">
        <property type="entry name" value="STAS_SulP_like_sulfate_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.750.24:FF:000024">
        <property type="entry name" value="Sulfate permease 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="entry name" value="STAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018045">
        <property type="entry name" value="S04_transporter_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001902">
        <property type="entry name" value="SLC26A/SulP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00815">
        <property type="entry name" value="sulP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11814">
        <property type="entry name" value="SULFATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01130">
        <property type="entry name" value="SLC26A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="77"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="275"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="370"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="407"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="436"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="STAS" evidence="6">
        <location>
            <begin position="528"/>
            <end position="659"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM31264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="780" mass="84827" checksum="A21D2E26F10E82FA" modified="2014-04-16" version="1">MAETISTRVGHAFAKLLRIDLSPIPSVVGDDTRTYGYYECEPTVGDWFRGHTPTAPQVRRYVWGLFPFLHWIGYYNVQWLIGDLVAGITVGAVVIPQGMAYAELAKLPPEYGLYSSFMGVLIYWFFATSKDITIGPVAVMSTLMGSIIIRVQAVHPEISPPVLASALAIICGAIVLFLGLLRLGFIVDFIPLPAITAFMTGSAINVCAGQVKTVLGEKAHFSTRGATYKIIIDTLKHLPSARMDAAMGLTALAMLYGIRSACNYGTRKQPHKAKLFFFLSTLRTAFVVLFYTMISAAVNLHRRDHPAFKLLGNVPRGFKAAGVPKIDIPIIKAFLGELPAAVIVLLIEHIAISKSFGRVNNYTIDPSQEFIAIGISNLLGPFLGAYPATGSFSRTAIKAKCGVRTPLAGVITAVVVLLAIYALPALFFFIPKSSLSAVIIHAVGDLTGIYCTIAVSLAVLLFRLAKARGQFLGYIQVHSVVGDHILNASQGDPNTEFEDDTEGSRRIYLPTEHDGGTNPRIKIHQPAPGIFIYRVSEGFNYPNANHYTDHLVSHIFKATRRTNPQAWETTGDRPWNDPGPTRAERKLLLSEEAPTSPLPTLRAIILDFAAVNNVDVTSVQNLIDVRNQLDRWASPDSVQWHFANIHNKWTKRALAAAGFGFPTVSDGTGPRCQRSIFNVAEILDGGLPALVTQSQVGGLEEWSKDLEVGLNVQESSASSVMGVTEDNIQVVQTGESTKVNTHRRRGRSGVGTCMAAVDGINRPFFHVDLTSALKSSMADS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W6QAX8</accession>
    <name>W6QAX8_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CTP synthase</fullName>
            <ecNumber evidence="9">6.3.4.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">UTP--ammonia ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PROQFM164_S01g000671</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>UTP + L-glutamine + ATP + H2O = CTP + L-glutamate + ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:26426"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Pyrimidine metabolism; CTP biosynthesis via de novo pathway; CTP from UDP: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the CTP synthase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.2" evidence="9"/>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QAX8"/>
    <dbReference type="STRING" id="1365484.W6QAX8"/>
    <dbReference type="OMA" id="HAAMYCH"/>
    <dbReference type="OrthoDB" id="1739076at2759"/>
    <dbReference type="UniPathway" id="UPA00159">
        <property type="reaction ID" value="UER00277"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097268">
        <property type="term" value="C:cytoophidium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003883">
        <property type="term" value="F:CTP synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044210">
        <property type="term" value="P:'de novo' CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019856">
        <property type="term" value="P:pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03113">
        <property type="entry name" value="CTPS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01746">
        <property type="entry name" value="GATase1_CTP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000207">
        <property type="entry name" value="CTP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000069">
        <property type="entry name" value="CTP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004468">
        <property type="entry name" value="CTP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017456">
        <property type="entry name" value="CTP_synthase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033828">
        <property type="entry name" value="GATase1_CTP_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003792">
        <property type="entry name" value="PRK05380.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00337">
        <property type="entry name" value="PyrG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11550">
        <property type="entry name" value="CTP SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11550:SF0">
        <property type="entry name" value="CTP SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06418">
        <property type="entry name" value="CTP_synth_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 9" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="3 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CTP synthase N-terminal" evidence="11">
        <location>
            <begin position="2"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamine amidotransferase" evidence="10">
        <location>
            <begin position="321"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU810713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF06418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDM26862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="588" mass="64913" checksum="4739FBEBBB3B99CD" modified="2014-04-16" version="1">MKYIVVSGGVISGAGKGIVASSAGLLLQSKGFVVSTIKIDPYINIDSGTMSPLHHGEIFVTDDGGEISLDLGNFERYLSTTLQHGHNITTGKIYLDIISRERAGDYLGKTVQVVPHVTNAIQNCIERVAKIPVDESQAEPDVCIIELGGTVGDIESSPFIYALAQLRKRVGKENLVQIHVAYVPVVPPGASGEQKTKPTQRSISDVRSAGLSPLLVACRCEVPLDPGTIQKIANMCSMEPEQVISVHDGPTTYHLPLLLEKQNLLSILCEYLQLPLGQTPTQRIEQGRRTWSDWVHLVQSQDTITDTVSIALVGKYTSNKDAYLSVSKSIEHAAMYCHKKVKIVWIDSAHLEQETYQNSAVKYHKAWHDLCSAKGIVVPGGFGTRATGGMIKAITWARVNKKPFLGVCLGMQLTVVEYARHVMGISDAGSQELHPESKNHVIIHMPERNQENGRDTMRLGKHPCIFKEGTEWSKLRSLYGPTISQIEERHRNQYEVNPEIVEELEKAGLAVVGKDATGKRIEIVEIRDHPFFVGVQFHPEYLSRVLRPSKVFLGFFAAAAKCLEKIPMALQQGRRSLAEEDEEAMGNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W6QB01</accession>
    <name>W6QB01_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Citrate synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S02g003373</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the citrate synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM33221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QB01"/>
    <dbReference type="STRING" id="1365484.W6QB01"/>
    <dbReference type="OMA" id="WVAHWNE"/>
    <dbReference type="OrthoDB" id="435022at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046912">
        <property type="term" value="F:acyltransferase activity, acyl groups converted into alkyl on transfer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.580.10">
        <property type="entry name" value="Citrate Synthase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.230.10">
        <property type="entry name" value="Cytochrome P450-Terp, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016142">
        <property type="entry name" value="Citrate_synth-like_lrg_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016143">
        <property type="entry name" value="Citrate_synth-like_sm_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002020">
        <property type="entry name" value="Citrate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036969">
        <property type="entry name" value="Citrate_synthase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11739">
        <property type="entry name" value="CITRATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11739:SF4">
        <property type="entry name" value="CITRATE SYNTHASE, PEROXISOMAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00285">
        <property type="entry name" value="Citrate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00143">
        <property type="entry name" value="CITRTSNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48256">
        <property type="entry name" value="Citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM33221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="441" mass="49258" checksum="8BDC6CB617CE5AEE" modified="2014-04-16" version="1">MSTGILFIRDSRTNANYEIPINRNAVRATDLQRIRAPSLNSNRADQVAHGLRVYDPGLQNTAVTESPISFSDHERGLLLYRGYTLDQLWGCDFEEMFHLLLWGTYPTASQFEELRRQLAQYMQVVPDIVRQTIVNLPKETSPLPLVLAGLSAYLACTPDVIPATTNPTIYQRDIKRADQIILRTVAAYAVVFGAVRSHRLGIPWKSPSIHQTYYENLFAMAGLVDPKTNRPDPTRVSCFRRFGNLNAEHGMALTVFSTVVTASSLTDPVSCLIATVAAAHGPLHFGATESAQLALRNIGEPKNVPAFIEDIKSGKQKLFGYGHRTYKGMDPRVRPIQSILKDMTDVNQPLLKVAEAIEEAASKDEFFSTRGLYPNADFYGNFVFTGIGFEPDMIPAAMLAHRIIGIMAHWREYMVNRGKLFRPIHLYTGHAEPTSGPRPKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>W6QBA4</accession>
    <name>W6QBA4_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="20 21">NADPH--cytochrome P450 reductase</fullName>
            <shortName evidence="20">CPR</shortName>
            <shortName evidence="20">P450R</shortName>
            <ecNumber evidence="20 21">1.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20 25" type="primary">cprA</name>
        <name evidence="25" type="ORF">PROQFM164_S02g001574</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="20">This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5. Involved in ergosterol biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19 27">
            <text>2 oxidized [cytochrome P450] + NADPH = 2 reduced [cytochrome P450] + NADP(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24040"/>
            <dbReference type="Rhea" id="RHEA-COMP:14627"/>
            <dbReference type="Rhea" id="RHEA-COMP:14628"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:55376"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="EC" id="1.6.2.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="20">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="20">Binds 1 FAD per monomer.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="20">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="20">Binds 1 FMN per monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="20">Endoplasmic reticulum membrane</location>
            <topology evidence="20">Single-pass membrane protein</topology>
            <orientation evidence="20">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="20">Mitochondrion outer membrane</location>
            <topology evidence="20">Single-pass membrane protein</topology>
            <orientation evidence="20">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="20">Cell membrane</location>
            <topology evidence="20">Single-pass membrane protein</topology>
            <orientation evidence="20">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="20">Belongs to the NADPH--cytochrome P450 reductase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="20 21">In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="20">In the N-terminal section; belongs to the flavodoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.6.2.4" evidence="20 21"/>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QBA4"/>
    <dbReference type="STRING" id="1365484.W6QBA4"/>
    <dbReference type="OMA" id="QKRYQRD"/>
    <dbReference type="OrthoDB" id="1856718at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003958">
        <property type="term" value="F:NADPH-hemoprotein reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06204">
        <property type="entry name" value="CYPOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.990.10:FF:000009">
        <property type="entry name" value="NADPH--cytochrome P450 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000100">
        <property type="entry name" value="NADPH--cytochrome P450 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000111">
        <property type="entry name" value="NADPH--cytochrome P450 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.360:FF:000024">
        <property type="entry name" value="NADPH--cytochrome P450 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000001">
        <property type="entry name" value="NADPH--cytochrome P450 reductase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.990.10">
        <property type="entry name" value="NADPH-cytochrome p450 Reductase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="CysJ-like_FAD-binding"/>
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        <property type="entry name" value="FAD-bd_FR_type"/>
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        <property type="entry name" value="Flavdoxin-like"/>
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    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
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    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
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    <dbReference type="InterPro" id="IPR023173">
        <property type="entry name" value="NADPH_Cyt_P450_Rdtase_alpha"/>
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    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
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        <property type="entry name" value="P450R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384:SF17">
        <property type="entry name" value="NADPH--CYTOCHROME P450 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00667">
        <property type="entry name" value="FAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00369">
        <property type="entry name" value="FLAVODOXIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 20" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 20 21" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 20" id="KW-0274">FAD</keyword>
    <keyword evidence="3 20" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4 20" id="KW-0288">FMN</keyword>
    <keyword evidence="2 20" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="14 20" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="16 20 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="15 20" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 20" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="9 20 21" id="KW-0521">NADP</keyword>
    <keyword evidence="12 20 21" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="18 20" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="13 20" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="17 20" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="23">
        <location>
            <begin position="66"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="24">
        <location>
            <begin position="277"/>
            <end position="538"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="251"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="72"/>
            <end position="77"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
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        <location>
            <begin position="123"/>
            <end position="126"/>
        </location>
        <ligand>
            <name>FMN</name>
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        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="169"/>
            <end position="178"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="296"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
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        <location>
            <begin position="451"/>
            <end position="454"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
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        <location>
            <begin position="469"/>
            <end position="471"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="486"/>
            <end position="489"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
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        <location>
            <position position="552"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
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        <location>
            <begin position="614"/>
            <end position="615"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
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        <location>
            <begin position="620"/>
            <end position="624"/>
        </location>
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            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
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        <location>
            <position position="656"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
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        <location>
            <position position="694"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
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        <source>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00049342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PIRNR" id="PIRNR000208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CDM31424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="695" mass="76734" checksum="BC215E01863905EE" modified="2014-04-16" version="1">MAQLDTLDLVVLVALLVGSVAYFTKGSYWAVPKDPYASSAATQNGAAKSGKTRDIVEKMEETNKNCVIFYGSQTGTAEDYASRLAKEGSQRFGLKTMVADIEDYDYENLDKFPDDKVAFFVLATYGEGEPTDNAVEFYQFFTGEDVAFESGASAEDKPLSSLKYVTFGLGNNTYEHYNAMVRQVDAALTKLGAQRIGTAGEGDDGAGTMEEDFLAWKEPMWAALSEAMSLQEREAVYEAVFSVVEDDEKSPEDESVYLGEPTASHREDRAKGPFSAQNPYIAPIVESSELFTVKDRNCLHMEISIAGSNLSYQTGDHIAIWPTNAGAEVDRFLQVFGLEEKRHSVINVKGIDVTAKVPIPTPTTYDAAVRYYMEVCAPVSRQFVSSLAAFAPDEESKVEMVRLGNDKDYFHEKIADQRFTIAQALQSITSKPFTAVPFSLLIEGLNKLQPRYYSISSSSLVQKDKISITAVVESVRLPGASHMVKGVTTNYLLALKQKQNGDPSPDPHGLTYSITGPRNKYDGIHVPVHVRHSNFKLPSDPAKPIIMVGPGTGVAPFRGFIQERAALVAKGEKVGTTLLFFGCRKSDEDFMYKDEFKTFQDQMGDSLKIITAFSREGAEKIYVQHRLKENAELVSDLLKQKANFYVCGDAANMAREVNLVLGHIIAQQRGLPAEKGEEMVKHMRSSGSYQEDVWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W6QBG9</accession>
    <name>W6QBG9_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DUF1446 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S02g001654</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QBG9"/>
    <dbReference type="OMA" id="YEHIGFP"/>
    <dbReference type="OrthoDB" id="10265871at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="AtuA-like_ferredoxin_dom"/>
    </dbReference>
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        <property type="entry name" value="AtuA_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47585">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47585:SF2">
        <property type="entry name" value="DUF1446 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G11420)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07287">
        <property type="entry name" value="AtuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23544">
        <property type="entry name" value="AtuA_ferredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyclic terpene utilisation N-terminal" evidence="2">
        <location>
            <begin position="8"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="AtuA-like ferredoxin-fold" evidence="3">
        <location>
            <begin position="516"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="472"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM31504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="628" mass="69183" checksum="9DCE7200CA495919" modified="2014-04-16" version="1">MAYKGRPVRIAGASGSASDRRQAIADFARHHPTDPIDVIIADFMSEFNMATAAGRRVDQTTSRVPTAPAYEPSFLEALEPALDDLAKYGIKLAVNAGVTDTKGLYEVVLRMVEAKNLDLKVAWVSGDEVLSTVQKELASGSEFRNVYTGDRLADWPFEPIYAQCYLGGLGIAGALAGGADIVLCGRVSDASPVIGAAYWYHGWQRDELDKLANAFVAGHLIECSNYVCGGNFTGFKALEYADGDGWTNIGYPIAEISAEGDVVITKQAHATGGAVTVDTCTSQLLYEIQGPWYYNSDVTAVLDNIRFLQCGVNRVAVHGVHCGPPPPTTKVGITARGGFQAEVWWFLTGLDIEAKARMLEAQVRHLLSPYSGRYTSLNFDLLGSSLSDPPNQNRATVPLRIVAQARHAEDLAPTRFLKHITDNIMQGYPGATFHLDMRQGFPRAIFEYYVTLLPQSAVQHRVHMPWKPTASAQTLDISPPANTRIYPSRQPSQPTARTDRPVDLARDFEPTSRGPLGWIVHARSGDKGTDANCGFWVRHSDEYEWLQALLSVDKVQELLGETARENTNLEIERFELPRLHAVHFLFRNLLDRGVGVTTTVDFLGKNVAEYLRARHVDLPVRFLNRGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>W6QBK4</accession>
    <name>W6QBK4_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidyl-prolyl cis-trans isomerase</fullName>
            <ecNumber evidence="5">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">ssp-1</name>
        <name evidence="9" type="ORF">PROQFM164_S01g000851</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="5"/>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QBK4"/>
    <dbReference type="STRING" id="1365484.W6QBK4"/>
    <dbReference type="OMA" id="DEVQCLH"/>
    <dbReference type="OrthoDB" id="2530521at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060261">
        <property type="term" value="P:positive regulation of transcription initiation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.10:FF:000066">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.40:FF:000026">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051370">
        <property type="entry name" value="PPIase_Pin1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000297">
        <property type="entry name" value="PPIase_PpiC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10657">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10657:SF4">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00639">
        <property type="entry name" value="Rotamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50198">
        <property type="entry name" value="PPIC_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 5" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="WW" evidence="7">
        <location>
            <begin position="4"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="PpiC" evidence="8">
        <location>
            <begin position="65"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="29"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM27042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="176" mass="19597" checksum="B4E40D9732C7413D" modified="2014-04-16" version="1">MADTGLPTGWEVRHSNSKNLPYYFNPSTKESRWEPPAETDTDKLKVYMAQNHTPAARSDPSGEGEGKIRCSHLLVKHRDSRRPSSWREADITRTKEEAIEILKGHEQRIQSGEITLGDLAVAESDCSSARKKGDLGFFGRGEMQKEFEDAAFGLQPGEVSSIIETASGVHLIERVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2024-10-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>W6QBP7</accession>
    <name>W6QBP7_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S02g001729</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QBP7"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM31579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="50" mass="5920" checksum="91CA98261B19B077" modified="2014-04-16" version="1">MLNARRWRLLFSQNRLYFWTISGVAIVVANEKLHLSIAIYKIVDRRGSDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W6QBX5</accession>
    <name>W6QBX5_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PROQFM164_S03g000927</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QBX5"/>
    <dbReference type="STRING" id="1365484.W6QBX5"/>
    <dbReference type="OMA" id="YIQVEDI"/>
    <dbReference type="OrthoDB" id="5979581at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050684">
        <property type="term" value="P:regulation of mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051334">
        <property type="entry name" value="SRPK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634:SF9">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM34203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="152" mass="16826" checksum="23D646F5795AB3AB" modified="2014-04-16" version="1">MTDSSYIQVEDIYHPEADVENSEDYVPGGYHPTLIGDTLCSGRYTVVHKLGFGGYSTIWLARDHQRQRYVSLKILTARASPDNHFPMKSDLAHSGKRFTPSLLGQFSFHGPNGHHRCLVGEPAGANVANPKEDSPNSCFRRTLLDLLPPSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W6QC90</accession>
    <name>W6QC90_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pre-rRNA-processing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">ipi1</name>
        <name evidence="9" type="ORF">PROQFM164_S01g001046</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">Component of the RIX1 complex required for processing of ITS2 sequences from 35S pre-rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the RIX1 complex, composed of IPI1, RIX1/IPI2 and IPI3 in a 1:2:2 stoichiometry. The complex interacts (via RIX1) with MDN1 (via its hexameric AAA ATPase ring) and the pre-60S ribosome particles.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the IPI1/TEX10 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QC90"/>
    <dbReference type="STRING" id="1365484.W6QC90"/>
    <dbReference type="OMA" id="CAGGWVK"/>
    <dbReference type="OrthoDB" id="361362at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120330">
        <property type="term" value="C:rixosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024679">
        <property type="entry name" value="Ipi1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16056">
        <property type="entry name" value="REGULATOR OF MICROTUBULE DYNAMICS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16056:SF2">
        <property type="entry name" value="TESTIS-EXPRESSED PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12333">
        <property type="entry name" value="Ipi1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="6" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Pre-rRNA-processing protein Ipi1 N-terminal" evidence="8">
        <location>
            <begin position="132"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU368021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM27237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="344" mass="37307" checksum="315250ED82421B9F" modified="2014-04-16" version="1">MGASSKRKKDKQKDFQKPKLKVGKTKAKPDNYTDTSFKSKAIVLTQQSLHLAAPTANAVFTHNLSLLNAKSDSQRRESLAYLTTTISSRPVNSPLPQPVSVILPSLLPLILDGSTSVRTQLLKLLRTLPPGDVEDHVAQLLPYVRAGMTHLAADIRSSAVEILSWMVEAAGESTVSCAGGWIKTLNCFLSVLGWHTEESSQWSSSRASFGKSGSQGKPMVKTLGTLAKFLDAGIGNPSISGVDSEMSGDDESPDWPFPLCQTAQHMISDSSTPFAYLNLFGKPRDEEGEMYETREDRYRVFSTRFQSAIERGIKSAREEGGELGRASSGVTKVLKEAIAYGPGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W6QCJ0</accession>
    <name>W6QCJ0_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Sodium/calcium exchanger membrane region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PROQFM164_S03g000924</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QCJ0"/>
    <dbReference type="STRING" id="1365484.W6QCJ0"/>
    <dbReference type="OMA" id="MHRIHSW"/>
    <dbReference type="OrthoDB" id="1699231at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015369">
        <property type="term" value="F:calcium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1420.30:FF:000016">
        <property type="entry name" value="Membrane bound cation transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1420.30:FF:000011">
        <property type="entry name" value="Vacuolar calcium ion transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004713">
        <property type="entry name" value="CaH_exchang"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503:SF18">
        <property type="entry name" value="CA(2+)_H(+) EXCHANGER, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503">
        <property type="entry name" value="VACUOLAR CALCIUM ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="167"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="209"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="242"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="553"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="588"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="618"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="649"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="679"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="10">
        <location>
            <begin position="107"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="10">
        <location>
            <begin position="554"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="289"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="400"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="12"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="292"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="315"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="330"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="351"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="406"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="419"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="474"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="493"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDM34200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="710" mass="76184" checksum="4A02A5D113C6255D" modified="2014-04-16" version="1">MHRIHSWAKAHASSSGLPDQSPSEQAADPVNSEKPSQHGQVNVPVEDPTPGSVTETNTKPGLLIRMRNGSGRFYHHTADAICHSWINVLLIFVPVGIACEAAGLNPALIFAVNAVAIIPLAGLLSHATESVASRLGDTIGALINVTFGNAVELIIFIIALVKNEIRIVQASLLGSILANLLLIMGMAFLAGGLRFREQIYNSTVTQMSACLLSLSVVSLLLPTAFHASWSDSNNADRETLKVSRGTSVVLLLVYILYIIFQLRTHSYLYASIPQAIIDEESKPGVLAEFMNSSSDSSSSSSDESDDTTTSWTTAKRIKRAMKYRRHRKSSTSSKGTISHNSFQKRAMASTSNENHGSISNSIGSNEHAIELSDEIRYDADDDILPSSAVRSRDFGLALSRMDSKASKKSKKRDHKRRETQKAEKKAQIEASEHSGPSDQRPVLKGFPSAPNVVGLESVDDPRKRRSPFGPIPSLLSNTVFSSQSPAGSPRMGATSSRPGICRSNSLPAHTSRPPLAGNAVQFARGASRLTEHNDIVGPEIASQAPEPTMSRTAAVVMLLLSTALVAVCAEFLVDAIPDMIASSNVSEAFIGLIILPIVGNAAEHVTAVSVATKNKMDLSIGVSVGSSIQIAIFVTPLVVILGWCMDKDMSLYFTLFETICLFVTTFVVNFLVLDGRSNYLEGVLLIAAYIIIALSAFFYPPSTKSSVIAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W6QCL9</accession>
    <name>W6QCL9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Proteinase inhibitor, propeptide</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S03g001167</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protease inhibitor I9 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QCL9"/>
    <dbReference type="STRING" id="1365484.W6QCL9"/>
    <dbReference type="OMA" id="MYFNVTM"/>
    <dbReference type="OrthoDB" id="5518345at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004866">
        <property type="term" value="F:endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042144">
        <property type="term" value="P:vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.80:FF:000005">
        <property type="entry name" value="Proteinase inhibitor I2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.80">
        <property type="entry name" value="Peptidase S8 propeptide/proteinase inhibitor I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052471">
        <property type="entry name" value="PBI_I9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037045">
        <property type="entry name" value="S8pro/Inhibitor_I9_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28288">
        <property type="entry name" value="PROTEASE B INHIBITOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28288:SF2">
        <property type="entry name" value="PROTEASE B INHIBITOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM34443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="70" mass="7863" checksum="E20949DB95079759" modified="2014-04-16" version="1">MPLYNITLKTNAPVEELEKAKAFAREKGGVIRHEYSIIKGFTVEFPDDTVQTLKSTEHVHIEQDGAVSPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>W6QCR1</accession>
    <name>W6QCR1_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Beta-ketoacyl synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PROQFM164_S01g001193</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM164</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Secondary metabolite biosynthesis; terpenoid biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1365484.W6QCR1"/>
    <dbReference type="OMA" id="KDNIGHT"/>
    <dbReference type="OrthoDB" id="429813at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041068">
        <property type="entry name" value="HTH_51"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032088">
        <property type="entry name" value="SAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF21">
        <property type="entry name" value="NON-REDUCING POLYKETIDE SYNTHASE AUSA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18558">
        <property type="entry name" value="HTH_51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16073">
        <property type="entry name" value="SAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="2" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="9">
        <location>
            <begin position="386"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="10">
        <location>
            <begin position="1294"/>
            <end position="1601"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="8">
        <location>
            <begin position="1651"/>
            <end position="1725"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="7">
        <location>
            <begin position="1294"/>
            <end position="1422"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="7">
        <location>
            <begin position="1450"/>
            <end position="1601"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="7">
        <location>
            <position position="1325"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="7">
        <location>
            <position position="1508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDM27382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="2495" mass="273738" checksum="1C58448B5E316427" modified="2014-04-16" version="1">MAEPPKTPGRPVCVVFGPQSSEIDETLFYISRNIDENPSLGFLKDVLQELPSLWSPITDAWSSLSSIPGATQLTVLAECVQGTTAAPKSAMNVFMTPLTVIRQIIDVWKFKEESQNRCRIVDAQGFCVGFLAAVAVASSNDSNEFEDIASTMIRLAVCIGAAVDLDGILHGPTRSVALRWKSDSEKEQLDRVLGSSSTAYISCFTDATSVTVTVAEDEVDDLTKELGGHGLSVKIIDLKGRFHHSRHVTAVQYLADLCETDARFRLARTSPCVLPLRSNVDGHVIGKRFAIHKTALESILTKPSQWAITVSAAFEQARETDDDLAFVVIGTGQFVPRLVRTRVLDHLNNKWSDTKQHAILPNGIHRSSSTTRSRPSIDMAPIGPTVTPIAITGMGCRYAQADSPEQLWEMLELGRCGVNALPNERFKMENLLREPKGPFWGNYLANPDVFDHRFFGISAREAEAMDPQQRLLLQVGYEAMESAGYCGLRTFNIPSDVGCYVGVGSDDYTDNVGSSNANAFSATGTLQAFCTGRLSHYFGWTGPSVVVDTACSSAAVSIHLACKALQTNECSIAVAGGVNVMTSPRVTQNLAAASFLSPTGASKAFDASADGYCRGEGAGLVVLRPLKDAIHNGDPILAIIGGSAVNQGSNRSPITVPDSDSQISLYRKALVTSGVRPEDVTYVEAHGTGTQVGDPIEFESIRKTFGRPARTERLYVGSIKDNIGHTETSSGVAGLLKTVLMMQKHQIPKQANFVQLNPKIPTLDDAAIAIPTKSIHWPSAANSSSTAVAMVTNYGAAGSNAALVVKQYKAKSGLSNPVSPLPSEVPVILAANTVESLRSYCKALLSSVCDAQLTSCQDTAYNLAIKQSRDMDYVSAFSIPVDRPNELIAKLESISCETTNLEKQPAARLPVVLCFGGQNGNEATISEDLFNQCELLQYHLTECEKVCQTLDLPSLFPSIFQPGPIEDTVSLHCILFSIQYASAKSWIDSGLQVDRIIGHSFGQLTGLCVGGGLSLSDALYLVSERAKMIHSMWGSERGAMLLVEGSEVEVQGLLNRAAEHMADVAVDVACVNGPRNTILAGDERSLQMIEKLSAKAPSILRTKRLKNTHAFHSRLVDNIVPPLTKVAQQLQYKPLSIPIEACSQYDDWTYVTPGKIVDHSRRRVDFQTAVERVAQRIQGPAIWLEAGSASPIIPLVRRVIDTVAAFSNGHVYQALDLGGALAHRSLSQATCNLWSRGVKVQFWQFHDSQAKSYNWINLPPYQFAQTRHWIGYDPNAFASLPEVKPTVPSSDAPKEFVQLLTKQPTECVFAINTNDPLYQECTQGHAVLDQNLCPASLYFEIIVRAAGLIRPENDISPAMPHLKDLSISAPLVLNPRGNVMLSLTRARVGDSPWSFSLFTREPNKNKVTTHATGEISLHPFGQNTPLFVRLHSMNRLIDSSRVDSIANSRESSGLKGFAVYQAFRRVVNYADYYRGVEQVFATDHEAAGIVNLPSSRTKDASCDPMLVDNFIQVAGIHVNCLSETKEDEVFVCTGVGEILIGEAFMTRDPNCSRSWAVYSNVDRSIKNKITCDTFVLDRETDKLAVTILSATFTSVSIAGLSRVLKKLNNQPDDKKVPLGQSLRDDSKVALNPTPQNALAAVPAPLHSAPDSGHFMVVQEMLCDLLGIASDELLPSSNLEDIGVDSLMRTEVLVEIKKRFNFTIDTSSFVEIPDILTLVQTIFPDAATAPLTNGVHPSLQIETTEAVDSERNTHVIPTPISDEEIHGLIDIAPGLFTDIQRSMVHSQSTQWDGFCESVYPRQMALVTAYVVEAFKSLGVSLESFEAEHLIPQVPVLQQHSKVRSQLYSILQFSNLIRATDHGFVRTSVPVSTISSDVLHEEIIRLYPQHTSEHNLLRTTGSRLSDCLSGAADPLSLLFQDAEARRLMEDVYTNAPMFKAATNHLAQYLVNLLGRVDTTREIKILEIGGGTGGTTKALLSQLTAVPGLRFQYTFTDLSSGLLTLARKKFKHYSFMKYQVLNIERAPTPDMLGQYDIVLSSNCVHATRSLVQSCSNINKLLRPDGLLCLIELTRNLFWFDLVFGLLEGWWLFEDGRQHALATEHVWKQTLSQSGFQWVDWTYNDSQESNVLRVITASPTSAVILPPSPRSPLYLMNEETIVYGKNDGVELSADIYYPRDLQPIGKPRPIALLIHGGGHIMLSRRDIRSKQVRMLLNAGFLPVSVDYRLCPEVSLTEGPMHDVCDALCWARHVLPSLTLGRPDIQPDGTQAVAVGWSTGAHLAMTLAWTSQQRGIAPPNAILAFYGPTDYEDSFWSQPNFPYGKNAASPEMRYDLWEGIYETPITAYNPPVDQKALGGWMSPADPRSRIALHMNWKGQSLPMLLHGGRFWSDHKDGDCGEELPVPTLEEIQAVSPLAQIRNGHYKTPTFIIHGTLDDLIPVEQAQRTSQELVTKGVEVQLRVVDKAVHLFDIYPGFEKDQAASRAVEDGYEFLRDHVRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W6QCU0</accession>
    <name>W6QCU0_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial glycoprotein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S02g002160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QCU0"/>
    <dbReference type="STRING" id="1365484.W6QCU0"/>
    <dbReference type="OMA" id="RWLNNVK"/>
    <dbReference type="OrthoDB" id="278212at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:cytosolic ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.280.10:FF:000007">
        <property type="entry name" value="Regulatory protein SUAPRGA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.280.10">
        <property type="entry name" value="Mitochondrial glycoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003428">
        <property type="entry name" value="MAM33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036561">
        <property type="entry name" value="MAM33_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10826">
        <property type="entry name" value="COMPLEMENT COMPONENT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10826:SF1">
        <property type="entry name" value="COMPLEMENT COMPONENT 1 Q SUBCOMPONENT-BINDING PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02330">
        <property type="entry name" value="MAM33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54529">
        <property type="entry name" value="Mitochondrial glycoprotein MAM33-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM32009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="288" mass="32559" checksum="04640542995161A3" modified="2014-04-16" version="1">MLSLRTVTRSIPRTFSRSIATSALRPAFPKPALRQSWNQATKPAYAAFSTSSIFKAPSSEVDIELLAKLEDELRHEKSSEIPEFEEQLESIEETIKDGEWQVKDVAGEQEVILTKKFGTENIRVSFTVADIQNISEQEDFDDASLSDEMDFQNQSRGQDAEASAEDIEQPEPSFPARVTITVEKPNNGALLIQTVVQDGVFQIEEVSHFANAELAQSQTAEKDWARQSLYAGPPFENLDEDLQGLWDRYLEDRGLNAEFANMVPDYISVKEQKEYLRWLETVKNFIGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W6QDL0</accession>
    <name>W6QDL0_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PROQFM164_S03g000890</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QDL0"/>
    <dbReference type="STRING" id="1365484.W6QDL0"/>
    <dbReference type="OMA" id="YIYGIMY"/>
    <dbReference type="OrthoDB" id="6770063at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF60">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="157"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="226"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="251"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="285"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="312"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="384"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="429"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="472"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="499"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="531"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="565"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="159"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="109"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="9"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="35"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="109"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM34166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="601" mass="66341" checksum="813922B26CB3C494" modified="2014-04-16" version="1">MSDHKESGSTRPQSASISSTDSEFQASRTQSRSQSLAGSLRTRLRSLSNSGMTQVDRVYSGRHLNDQSVYHSDEFDGSDDDEPSVGNEHMPDIIQEVRNGIVNERDLDLERADTAQPELEKSRTSRSNRSRHDPKLVQWDGPEDPENPKNWSSKKKWAAVITVSLFTFISPVSSSMVAPALPSLVADLKVTDEVVSQLMLSIFVLAYAVGPLFLGPFSEIYGRTIVLQLANLFFLVFNIGCAVSRTKVQMIVCRFFAGLGGSAPLAIGGGVLSDCFRAEERGKGIAIYSLAPLLGPALGPIAGGFIAENTTWRWVFYSTSITDGLIQLMGLFFLRESYGPKILLDRAVRLRNETGDESYQTEAERQNKTLPEVLRSSLIRPFRLLLTQPIVQVLALFMAYIYGIMYLVLSTFPTLWTSPNYYNESTGIGGLNYISLGLGFWLGSQICAPLNDRIYRRLKARNGGVGKPEFRVPLLFVGAFFIPSGLFIYGWTAQYHCHWIAPNIGAVLFGTGNIIAFQCIQTYMVDTYTRFAASALAASAFLRSLAGFGFPLFAPYMYSALNYGWGNSLLAFVAIVIGVPAPVFLWKFGETLRKKSTYAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W6QE67</accession>
    <name>W6QE67_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Haemerythrin/HHE cation-binding motif</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S03g001045</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QE67"/>
    <dbReference type="STRING" id="1365484.W6QE67"/>
    <dbReference type="OMA" id="HMRDEES"/>
    <dbReference type="OrthoDB" id="9983919at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.520">
        <property type="entry name" value="nmb1532 protein domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012312">
        <property type="entry name" value="Hemerythrin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35585">
        <property type="entry name" value="HHE DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_4G00730)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35585:SF1">
        <property type="entry name" value="HHE DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_4G00730)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01814">
        <property type="entry name" value="Hemerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hemerythrin-like" evidence="1">
        <location>
            <begin position="15"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM34321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="201" mass="23415" checksum="5A5E2DC49AE9BC90" modified="2014-04-16" version="1">MNSRLFTISANMVRISDVIKDDHRKLESYYNIIVNSEDQDEQTRYQNQFTWELARHAVAEELVVFPALEKLRAGKEQLDDDRREHKALKEMLNVFQDLNSSDPRFFPTITLLMEGLAQHMKDEEANDLAILEESLTSDESEKLAESLSRTKIFVPSRSHPHDLDNPRYETAVDLLTAPLDHLQDLFRRWPDEESTLTAPME</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W6QF52</accession>
    <name>W6QF52_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ankyrin repeat-containing domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S03g001842</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM35115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QF52"/>
    <dbReference type="STRING" id="1365484.W6QF52"/>
    <dbReference type="OMA" id="HFSVAAY"/>
    <dbReference type="OrthoDB" id="426293at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24173">
        <property type="entry name" value="ANKYRIN REPEAT CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24173:SF74">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="23"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="57"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="125"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM35115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="228" mass="25111" checksum="1DD127D9BC5E1F57" modified="2014-04-16" version="1">MEVTARFCIQNGAHVEVTDIHDHDRTPLFWAACKGYEAVVKLLLETGRVNADSKDSHSETPLLAAAQNGHEAVVKLLLDTGSVDVNSKCAYETPLFRAAYHGHEAVVKLLLKTGHVDLQPKDDPFGWTPLYVAAWHGYEAVVKLLLATEGVDADSKDSNGWTPLLRAAQAGHEAVVECLLETEQVVVQPEEGPGDWTPLSVATQNGHEAVVELLRWSEWRSFWNRAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W6QFE9</accession>
    <name>W6QFE9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S01g002108</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QFE9"/>
    <dbReference type="STRING" id="1365484.W6QFE9"/>
    <dbReference type="OMA" id="YRCKVPA"/>
    <dbReference type="OrthoDB" id="5062908at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059009">
        <property type="entry name" value="Znf_C2H2_17_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059095">
        <property type="entry name" value="Znf_C2H2_17_2nd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26177">
        <property type="entry name" value="zf_C2H2_17_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26176">
        <property type="entry name" value="zf_C2H2_17_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-domain containing protein first zinc finger" evidence="3">
        <location>
            <begin position="360"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-domain containing protein second zinc finger" evidence="2">
        <location>
            <begin position="399"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="236"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="433"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="42"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="270"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF26177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM28297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="560" mass="62076" checksum="0920F1CB600575EC" modified="2014-04-16" version="1">MSPRNTSDSDRVSISQSMHTSMVSGISNMASRSIQDDEISSHDSSSLCSSIRTAHGNPQDMKDWTLNRQDSLDQAMSKSDSSEVHMLSFSLSQQLMTPTVGPNDIMYPGMDFPAVPDMDHEMTRDLYNSFLDFSSVENDVCVGNGTPDDALSIGHSSHSTEDGHYITGPEWTPMMHDTHYPGTTMEYASGLYQTAPVSPPLTDASNDISCSHAGYSSFMAPDDALLGDFTTSPIGTTHGLNPAEPLFPSSSINDRDPHRTIRPSKPSRRSALSSVSQQQIKTEPDFFPTLPVREPARPRSKEGVEARNPREHQYYSMSTHSDGKYYCPFATGEKPCSHPPTTQKCAYQQVLPKYLDSHLKPYRCKVPACIDAQLRFSSNACLFRHEREAHGLHGHGDNPHLCLWEGCERAVPGNGFPRRWNLYDHMRRVHDYATSERHSSPETSPGAGQIKKKEPTGRKRRVTGATPAPTMKRTRSVNSQASSIKASQASASLSQHLQNAEQNFFKCRSRLLEELSAISPKDTIMHEKVNAGFQELFTLGLNYRQIEASQAVSHMPNGLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W6QFS1</accession>
    <name>W6QFS1_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S03</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S03g001528</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QFS1"/>
    <dbReference type="STRING" id="1365484.W6QFS1"/>
    <dbReference type="OMA" id="HEPYNVG"/>
    <dbReference type="OrthoDB" id="6499973at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM34801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="284" mass="33291" checksum="4887AA6FBFB0DB63" modified="2014-04-16" version="1">MPWNPRQPSIFHDESWPTPWRSSEFPPEETFVERINRQHANPEWESVPHFLYYESGRSGGWPWGWAIYRTSYLNTSDQDWTRAIEKLDEACMADLEFYERSWHRFDLKCVEMVREGYRNVIFEDPALEGASEAVIQRRHKEWVESHGLRISSGIPRLGYALLLDDRCIRSILASAAPRKPSVIEQGLPWPKINDKPGGMVGYVNFIDSFFRPEDPENDYGEYYRGLVRVHLDCLAHFAIYCEDLETGEQEWGEYGMDIPDNVFYTDGHCSKTELKEISTIFYLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W6QFV1</accession>
    <name>W6QFV1_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thioesterase superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S04g000141</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QFV1"/>
    <dbReference type="OMA" id="AFAPYMW"/>
    <dbReference type="OrthoDB" id="506431at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03443">
        <property type="entry name" value="PaaI_thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052061">
        <property type="entry name" value="PTE-AB_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47260:SF2">
        <property type="entry name" value="THIOESTERASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47260">
        <property type="entry name" value="UPF0644 PROTEIN PB2B4.06"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioesterase" evidence="1">
        <location>
            <begin position="161"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM35260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="283" mass="30771" checksum="6BCA59055FCBE535" modified="2014-04-16" version="1">MSHISQTARRLFRSQPLSAFRTYSPAAPIARLHEQHPNRSAVVHDQALPSQTDGSPLLSQTQSLHNERTGLDKLVSHVPLVQKLRGTQSTYKETRPHLAIPPHLRQHHFVGGSLTGVGKLAFAPYMWLSTGKSGTGTDSADRASSVVSVFHIGQDVCGHPGFVHGGLLTVLFDEVFARCVSAAFPSGLGMTANLNVDFRKPALPDRMYVMRTKTVKVEGRKAWVEGRMTYLPLTVPLSADGHTIVPDASLLHEDSEGAVMVAEAKALFIEPKFADSMVSVYSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W6QG30</accession>
    <name>W6QG30_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PROQFM164_S01g002423</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QG30"/>
    <dbReference type="STRING" id="1365484.W6QG30"/>
    <dbReference type="OMA" id="ACINESQ"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF237">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE ATNE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM28612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="311" mass="35528" checksum="C4247A35C9724E94" modified="2014-04-16" version="1">MDIWRCHQKYGNHIRYAPDRLTFNTAQAVMDIYGIGSRVRKSKVYETLVHQAPNTLTLRDKKKHAQRRRIMSQGFSDAAIRSFEPRVLELVQRLCGILQGDLNSNDGKWSKGQDMAKWFDYLTFDIMSALVFSASYDTIRQEKFRPIINAIEESNVRVSVILQAPILTLFRLDKRLFSRSILWRNRFIKFIRRTVSERVKKSSLLKERDVFSYLKSAKDTVTAKTLRIDELGGEAATLIVAGSDTTATTLAATLFYISREPSVYERVTREVRSCFASAEEIHAGTQLNSCQYLRACIDEALRLSPPAGSAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2024-10-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W6QGE2</accession>
    <name>W6QGE2_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S04</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S04g000764</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QGE2"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM35883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="44" mass="4828" checksum="0BBDE32232912DA3" modified="2014-04-16" version="1">MSPECYWLGRGEGDRSTPQGLQANEGAPVEAPARKPNQIPCRIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W6QGY1</accession>
    <name>W6QGY1_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Acyl-CoA dehydrogenase/oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PROQFM164_S04g000964</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM36083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QGY1"/>
    <dbReference type="STRING" id="1365484.W6QGY1"/>
    <dbReference type="OrthoDB" id="10254877at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000002">
        <property type="entry name" value="Acyl-CoA dehydrogenase fadE12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050741">
        <property type="entry name" value="Acyl-CoA_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083:SF17">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE (AFU_ORTHOLOGUE AFUA_2G16630)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083">
        <property type="entry name" value="MEDIUM-CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="7">
        <location>
            <begin position="25"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="7">
        <location>
            <begin position="95"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="6">
        <location>
            <begin position="154"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM36083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="276" mass="30161" checksum="1A4DEEBE84612197" modified="2014-04-16" version="1">MASFSTIPFADPLWLNRGYSPYYNDSHRRLQKEVREYVDTYIAPFCEEWEKQGVVPQEVHKRHAELGYTAVSSFPLAVNYLNGQRLPGDIKPGDWDGFHDIVVIDELARCGYLGIVWALGCGNSIGGPPVINFGNDDQKRRFLPDMLKGNIRFCLGVTEPDAGSDVAGITTTAERNGDVYIVNGAKKWITNGIFADYCTAAVRTGGEGTQGISALIIPLKAPGVTCKKIENSGVHASGSTYIEFDQVEVPVANLLGVENKGFPVIMNSMFPLDSHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2024-10-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>W6QI98</accession>
    <name>W6QI98_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S05g000376</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QI98"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM36543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="45" mass="4857" checksum="DBD63B2D6D86D75B" modified="2014-04-16" version="1">MTPTELSIPLQISLRLGTLGCLCASLQFLLYYEAGADQEATSCFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>W6QID4</accession>
    <name>W6QID4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Zn(2)-C6 fungal-type DNA-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PROQFM164_S03g000688</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QID4"/>
    <dbReference type="STRING" id="1365484.W6QID4"/>
    <dbReference type="OMA" id="DQGFQYF"/>
    <dbReference type="OrthoDB" id="422427at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051711">
        <property type="entry name" value="Stress_Response_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47540:SF1">
        <property type="entry name" value="ACTIVATOR OF STRESS GENES 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47540">
        <property type="entry name" value="THIAMINE REPRESSIBLE GENES REGULATORY PROTEIN THI5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="57"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="140"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="212"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="679"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="729"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="839"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="23"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="230"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="691"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="885"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="910"/>
            <end position="929"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDM33964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="1021" mass="113264" checksum="FC49C72F343A5F77" modified="2014-04-16" version="1">MATTTSPLSGENEEDPAPMTDLKYSHDDDHHDTPTPDATIMDSKSLPAQKRRRVGRACDECRRKKIKCDGKQPCTHCTVYSYDCSYDQPSNRRRNPAPQYVEALENRLQKAEALLRIVLPNVDLDDPQLDLHATEQKFTAAQKSKATEDVRPSGALDPAQEGADEGLLETMVDNSGCLDRDDQGHWDYHGHTSGVLFVRRLRKQLGAADITAPMARSRPSISAHMMDSPKSVSESPQDSTLPPTHDLPPRAAARRLCHNAIDHACSLMKFVHIPSFFASLERIYDTPPEQFTNQDHSFLPLLYIAIAVGCLFSDDESGQGTLDLAGYEGAIGQGFQFFKAGRQLLEITDCRDLVSLQAICFMVLFLQSSAKLSTCYSYVGIALRSALRLGLHRSVAADFNPLERELRKRIFWVVRKMDIYVSTLLGLPQILSDDDIDQEYPMEVDGDFITSEGITQPPSNYTPLMAGCNAHTRLSNIILKVVKYIYPVKNARYRSKSDQRYMVSHSKIREIERDLQNWMEELPPALRPGTEVSPQLERVRQLLRISYAHVQMVMYRPFLHYVTGGSQARGVDKRSYACAAACVSVSRNIVHITTGMQKRGLLNGSFWFTMYTTYFAILSLIFFVLENPDSPTAKDGVLKDAMEGKNTLAGLAKKSLAADRCSQSLNCLFKTLPEMLKNRQSSKTPVNLKRPAPSNTAEPEPNNAEPQPKPSFEKTLPVRSSTFPVQMMSQPAVADDQNRRQRSVDNVQPVTNRPAADIHHQSTWISTTPDLLTETMTTPEHISSSSMTSSMPNQEPSSLAWAQQFTNPSNLPDLMPMMFPSDDPFAYPTQPMSTLEDAHFRHDPAGMPSQYSFDSAPGMGPTTPVDPSSAGGTPTFDFKNIPNYPITNSAGMKSSVPSHLRPSHSRTSSRVHSPISQSQTPTDASSSSDLVSIPNQNFVWKGYNFQANIATDMAPETAPQQQEMPAPNGLPPFSMGIDENIGMNMDLGITFDDLFGNNAAYRPGSGASAEDWAQWMNANSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W6QIP4</accession>
    <name>W6QIP4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="9">NADPH-dependent FMN reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PROQFM164_S05g000098</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homotetramer.</text>
    </comment>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QIP4"/>
    <dbReference type="STRING" id="1365484.W6QIP4"/>
    <dbReference type="OMA" id="METEMND"/>
    <dbReference type="OrthoDB" id="8300214at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016655">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.360:FF:000027">
        <property type="entry name" value="Arsenical resistance protein ArsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014063">
        <property type="entry name" value="Arsenate-R_ArsH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02690">
        <property type="entry name" value="resist_ArsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43590">
        <property type="entry name" value="ARSENIC RESISTANCE PROTEIN ARSH (AFU_ORTHOLOGUE AFUA_5G15030)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43590:SF1">
        <property type="entry name" value="ARSENIC RESISTANCE PROTEIN ARSH (AFU_ORTHOLOGUE AFUA_5G15030)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0288">FMN</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADPH-dependent FMN reductase-like" evidence="8">
        <location>
            <begin position="105"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM36265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="315" mass="36229" checksum="867480D6279A878C" modified="2014-04-16" version="1">MLSYFIQRAPSTFRPAIPSSLLHPTYSARISSAVPQQVIANTRQIDVSYRTLELRPSEDSRDIRQKYRPFILSDDATEDWVNNLDLTTAMDMAELDLQLTNKRLRVLVLYGSLRRRSYSRLVALEACRILFRLGCDVRIFDPEGLPVKNDNDTDHPKVQELRELSVWSDRHVWVSPEQHGNLTAVFKNQIDWIPLTTGSVRPTQGRTLAIAQVCGGSQSFNAVNSLRILGRWMRMFTIPNQSSIPRAYTQFPDEGQPEDQRLMPSGNRDRLVDCMEEFVKYTILMRPHIGLFGDRFSEREEKKAKEEKMNAAAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W6QIS3</accession>
    <name>W6QIS3_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="13">NADH:ubiquinone oxidoreductase, B12 subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PROQFM164_S04g000782</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I NDUFB3 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QIS3"/>
    <dbReference type="STRING" id="1365484.W6QIS3"/>
    <dbReference type="OMA" id="VAFTAYC"/>
    <dbReference type="OrthoDB" id="521512at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022900">
        <property type="term" value="P:electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012576">
        <property type="entry name" value="NDUFB3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15082:SF2">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15082">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE B12 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08122">
        <property type="entry name" value="NDUF_B12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0249">Electron transport</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="13" id="KW-0830">Ubiquinone</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDM35901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="89" mass="10242" checksum="B8792C6FC852D976" modified="2014-04-16" version="1">MHAPNPTGFNMADYKAAASPSSIWAKRDPWARNETWRYCGPFSRFNRFKGLFPGFGIATVAFAGYCTYEHFFMKDDHHHGDAHHGEEHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W6QIU5</accession>
    <name>W6QIU5_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">4-hydroxybenzoate polyprenyltransferase, mitochondrial</fullName>
            <shortName evidence="9">4-HB polyprenyltransferase</shortName>
            <ecNumber evidence="9">2.5.1.39</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Para-hydroxybenzoate--polyprenyltransferase</fullName>
            <shortName evidence="9">PHB:PPT</shortName>
            <shortName evidence="9">PHB:polyprenyltransferase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PROQFM164_S01g003324</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>an all-trans-polyprenyl diphosphate + 4-hydroxybenzoate = a 4-hydroxy-3-(all-trans-polyprenyl)benzoate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:44504"/>
            <dbReference type="Rhea" id="RHEA-COMP:9514"/>
            <dbReference type="Rhea" id="RHEA-COMP:9564"/>
            <dbReference type="ChEBI" id="CHEBI:17879"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58914"/>
            <dbReference type="ChEBI" id="CHEBI:78396"/>
            <dbReference type="EC" id="2.5.1.39"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="9">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite biosynthesis; terpenoid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Mitochondrion inner membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
            <orientation evidence="9">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 9">Belongs to the UbiA prenyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.39" evidence="9"/>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QIU5"/>
    <dbReference type="STRING" id="1365484.W6QIU5"/>
    <dbReference type="OMA" id="AKRHTHF"/>
    <dbReference type="OrthoDB" id="18170at2759"/>
    <dbReference type="UniPathway" id="UPA00213"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008412">
        <property type="term" value="F:4-hydroxybenzoate polyprenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140722">
        <property type="term" value="P:mycophenolic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd13959">
        <property type="entry name" value="PT_UbiA_COQ2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.140:FF:000008">
        <property type="entry name" value="4-hydroxybenzoate octaprenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1780:FF:000001">
        <property type="entry name" value="4-hydroxybenzoate octaprenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="entry name" value="UbiA prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1780">
        <property type="entry name" value="UbiA prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01635">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006370">
        <property type="entry name" value="HB_polyprenyltransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039653">
        <property type="entry name" value="Prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11048:SF39">
        <property type="entry name" value="POLYPRENYL TRANSFERASE AUSN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11048">
        <property type="entry name" value="PRENYLTRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="152"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="247"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="276"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="309"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDM29512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="335" mass="36346" checksum="09783FA4DE18BED7" modified="2014-04-16" version="1">MGVPEQLNGTANGKSKDSLSKQYGGVHAGGWVDYLPSYFVPYIQLCRLSPPAAFFIIFFPHFFGVIHAASVQKSSVEEVLRVSLILLGGSFFCNNASHAWNDLIDAPVDKLVARTCTRPIPRGAISLTAAFIFTCIQAAIAASFLLLLPSSIALAAVPNIFGTTYYPFAKRHTHFPQVVLGFCLTWGIMIGSAAMGVPEPWADKSTLSLFVASSLWVIIFDTVYAHQDLEDDLRVGVKSTAVLLQSYARLFLVVLFLGMSACLFACGYYSNMSMAFFSVTVGGCFLSVGAMVFFVDLKDPASCWSWFSQGFWMTGVAISGGLLAEYVYAANGSLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2024-10-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>W6QIW5</accession>
    <name>W6QIW5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S04</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S04g000832</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QIW5"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM35951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="53" mass="5545" checksum="DF62C369BD8436EB" modified="2014-04-16" version="1">MAFVRGSVRPAPSIVRVAVDGSCHAGASYPCPCLSMVGAHIPLTHQLLRVVCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W6QJ01</accession>
    <name>W6QJ01_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="8">FAD-binding, type 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PROQFM164_S05g000218</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QJ01"/>
    <dbReference type="STRING" id="1365484.W6QJ01"/>
    <dbReference type="OMA" id="RNAISHM"/>
    <dbReference type="OrthoDB" id="9983560at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF39">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004879868" evidence="6">
        <location>
            <begin position="24"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="7">
        <location>
            <begin position="116"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM36385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="537" mass="58730" checksum="F319D195E20A5A60" modified="2014-04-16" version="1">MRLHSCQYLVLFCIISILQPSTGLSSNCRCMPGDTCWPSSDDWSRFNTFIGGWLVNTQPLGQPCHDPLYIANECRSLRQQWTKPELHDLSSSSIMAATVANETCDAFTPRSKPCTLGAMVLYAVNASSPDDFIQTIRFSQERNIRLVIRNTGHEYASSSNNAMLSLIMHPSYLGKSTGAGALSIWTHYLKDIDFLNYTNAHYTGPAMRMAAGVQGTDINKAAYLKGLVIVAGECSTVGPAGGFTQGGGHSALSSQYGLSADQVLEWEVVDGMGRFLTASPTQNPDLYWALSGGGGGTYGVVYSMTVKAFPDFPVTGVVIQFENKNPSSHSFFEAVGHYHRHLPTYTASGGMAIAQITHSTFLLTPLTLPVYTAVEAKRLLAPFLQELHKLDISYTMNITESPSYFQHYTKLIEPDLMQLVQNAQYGGRLLPLDLIQHNNSQLTNAIQRITVDGVTFVGIGLNVSSSVTGNVWNSVLPAWRTAAITVILSTDWPTGANLTKMKTLADRMTTKWVPILTALSPDSGCYMSEARRQTFTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W6QJ47</accession>
    <name>W6QJ47_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex</fullName>
            <ecNumber evidence="6">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">Dbt</name>
        <name evidence="10" type="ORF">PROQFM164_S05g000646</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM164</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="6"/>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QJ47"/>
    <dbReference type="STRING" id="1365484.W6QJ47"/>
    <dbReference type="OMA" id="MPFCIKA"/>
    <dbReference type="OrthoDB" id="15567at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016407">
        <property type="term" value="F:acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031405">
        <property type="term" value="F:lipoic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045333">
        <property type="term" value="P:cellular respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06849">
        <property type="entry name" value="lipoyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000041">
        <property type="entry name" value="Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.10:FF:000007">
        <property type="entry name" value="Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.10">
        <property type="entry name" value="E3-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050743">
        <property type="entry name" value="2-oxoacid_DH_E2_comp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036625">
        <property type="entry name" value="E3-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004167">
        <property type="entry name" value="PSBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43178">
        <property type="entry name" value="DIHYDROLIPOAMIDE ACETYLTRANSFERASE COMPONENT OF PYRUVATE DEHYDROGENASE COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43178:SF5">
        <property type="entry name" value="LIPOAMIDE ACYLTRANSFERASE COMPONENT OF BRANCHED-CHAIN ALPHA-KETO ACID DEHYDROGENASE COMPLEX, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02817">
        <property type="entry name" value="E3_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47005">
        <property type="entry name" value="Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51826">
        <property type="entry name" value="PSBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4 6" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="8">
        <location>
            <begin position="43"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="Peripheral subunit-binding (PSBD)" evidence="9">
        <location>
            <begin position="180"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="124"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="124"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDM36813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="476" mass="51676" checksum="9282FD43F5204119" modified="2014-04-16" version="1">MGFSRSGGLAARNFRPCLPQNHLRIRSTLPPLLSRKFHASSLLWQIKSQVLKDVGEGITEVQIIQWYVEEGAHIEEWKPLCQYQSDKAVDDITSRYEGVIKKLHFETDDTVPTGRALCDIEVADGKYPDDNPAHESRAAPSEPTPASEIQAATQAVESSLITSPPIKAPDEIPKTKHASLAVPAVRGLLKSHGVNILEINGTGKDGRVMKEDVLKFVAERDSPALPTSVPTSVSVSPDTRQAESIVNLTPIQSQMFKTMTKSLNIPHFLYADELKINGINAIRKKIAFDKHDPTKITFLPFVVKAVSQALTEFPILNSKVDTTDPAKPKLVMRAKHNIGIAMDTPNGLIVPNIKDVASRSIFDIAAEIARLSALGKSGKLSPADLSGGTITVSNIGNIGGTYVAPVLVPTEVAILGVGRTRAVPVFDDDGQVTRGDMVNFSWSADHRVIDGATMAKMGNRVKDLVESPELMLLNLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W6QJ93</accession>
    <name>W6QJ93_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Src homology-3 domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PROQFM164_S01g003469</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1365484.W6QJ93"/>
    <dbReference type="OMA" id="ETWYFLA"/>
    <dbReference type="OrthoDB" id="6129702at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110085">
        <property type="term" value="C:mitotic actomyosin contractile ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140278">
        <property type="term" value="P:mitotic division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11889">
        <property type="entry name" value="SH3_Cyk3p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000168">
        <property type="entry name" value="SH3 domain protein (Cyk3)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.620.30:FF:000005">
        <property type="entry name" value="SH3 domain protein (Cyk3), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.620.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052557">
        <property type="entry name" value="CAP/Cytokinesis_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035553">
        <property type="entry name" value="Cyk3_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056409">
        <property type="entry name" value="Ig_CYK3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002931">
        <property type="entry name" value="Transglutaminase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46333">
        <property type="entry name" value="CYTOKINESIS PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46333:SF2">
        <property type="entry name" value="CYTOKINESIS PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24584">
        <property type="entry name" value="Ig_CYK3_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01841">
        <property type="entry name" value="Transglut_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00460">
        <property type="entry name" value="TGc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
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        <location>
            <begin position="7"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="83"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="278"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="363"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="666"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="771"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="866"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="88"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="166"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="198"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="278"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="476"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="507"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="528"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="614"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="666"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="726"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="791"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="809"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="869"/>
            <end position="884"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDM29657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="1484" mass="162102" checksum="B367832CC26B527D" modified="2014-04-16" version="1">MAQLPMRFPCWCRAVYSWGGETTRDLGFVEGDLIECLNAGDGQWWMGRLRRDRRAVGLFPSNFVELLGEDFVPVSRDTTSPMVLAGSSPINNPTSAPKKQKTVWRKPFQAHKEAVSPASVARRATATSPAAPAIPQTPPRAGGISRSTRPLRTHATAVRNQGSLARPTSSTSRPSSHNVSPRSSAEPERSPSMLPRGSVSSARPSSRDQPPLQSQERPYANTSNGSLSSTRRNPSPLPIREYSSGIITQGSTPLYRASSREPSPLQMQDYASQAMPQGITSSYRGSSREPSPLQMQEYPPPTIPPGGISSYQAQSREPSPMYMEDHPAASMPYGSMPSYRAASPLQIQDNSSAMVPYGRYTSYRAPSRGPSPPPMHEHSTMSSHGGMYRAPSRSQSPLYMEDHPPAPVPHGSMSSYRAPSPLPAREHPSALVSGGGMSSYRVPSREPSPVQMHEEREDSPPPPPPPPHRVVVGRSGSHSPQPPIHSQTRSHSPLPPMHSSQDRAHSPNPPSHYPNPSRSPTPLVMNDRYTTLNRTPSPSAASMHSALSATSGQSDMHGNTPSPLRDAMEDVMTSLEDMGLPRQDQSPSPSPVFNEPWSPEEFDTSQERTPQGNRRRDLTSMGFEGDKEQLQGGLVHRNSVYSHDHMDGPPQLNNYVQRMESRLRQLEDQNRSSEDRTGGQDDNGPPPPPPKHATYHPRNNSIPGQYAPLKTRRSGHDLRGDILNRTFTNKSSTTNSSSGMQSNGTSMTTSTDKTGQSVMSGFSAGGFSATSAGSFARRGGSERPNTAMDTVRSRGYSDARPETPFTGVSYHSSHNSSRQGASSAIPWTSTGLDSTDHSGVFGGLSTPKSKKQGFFKKIFETAKTGAASARSSISVGSNSPTKSNRGIDAVSPAPSHSHRNSGRDMGLGTNAIDWVQVRRDVNRASSPSRNERIDRAERCQMMDHPVIYSVEELYDTAEGDESIDGQPITEPTNFHAANLTLVDKSARFISSLPPMTNPMSLAQAYICRPYKSDVQRLRAIFTWVSEKISWEEPLDGVEVDMKRLLQAKRGTPEEISVLVHEMCTAVGLHTEVIRGFLKSPGDALDLESLSRPNHWWNSVLVDGEWRFMDCALANPTNPLRSKFISNNSSISESWYFLTRPLDLCYTHVPLYPEEQHICPPISPDVLLSLPTVCPPFFKLNIQMPDYDTSFLRIDGLEVMQLRMIVPPDVECAAEVEAPGFARDVDGDVFESGDIVRKRALVQPDWIRGQKRITIKAVLPGDEGQGVLKIYAGKKGLMHSSRDIPHPLALALPMTHTGENPPYDFVLRHPTPHAQRHDLYIMQPQCSRLAVNNTFVFAVRQHASAPASAMDESTSIGRASPSIFNRPASALSMVSSTTAGGSTVSGASNEFSASTSVISSGRSTSGRDKAAKLAIQSPSGKILRLTRKAEHMISSDNGNQSISDAVAEGSVWETVIKIGERGMWRGLVLADRAARWCVFCEWECV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W6QK95</accession>
    <name>W6QK95_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Apple domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S05g000249</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QK95"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.4.10">
        <property type="entry name" value="Hepatocyte Growth Factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004879667" description="Apple domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="129"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM36416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="171" mass="18203" checksum="28DA3E7715F4C9C7" modified="2014-04-16" version="1">MPSMHPLSLLTAILASALAESSSSSCWDTMHNSTLAVFSSAPIAFSLDRATALQCQAWCGQVSNCQAWVFVDQLLQCDLHRAAPVNVLPETNGFVFGGCDPSGAVLDLPRLIYAETMVEGAASTPTTQASAISLASSSSGATPEKTHGVPESIHPKVRRHGHSRHSRNHWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W6QL69</accession>
    <name>W6QL69_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Beta-lactamase hydrolase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">blh</name>
        <name evidence="3" type="ORF">PROQFM164_S02g000421</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QL69"/>
    <dbReference type="STRING" id="1365484.W6QL69"/>
    <dbReference type="OMA" id="GTWQYLI"/>
    <dbReference type="OrthoDB" id="449487at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050313">
        <property type="term" value="F:sulfur dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070813">
        <property type="term" value="P:hydrogen sulfide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07724">
        <property type="entry name" value="POD-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.15.10:FF:000033">
        <property type="entry name" value="MBL fold metallo-hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051682">
        <property type="entry name" value="Mito_Persulfide_Diox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044528">
        <property type="entry name" value="POD-like_MBL-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43084">
        <property type="entry name" value="PERSULFIDE DIOXYGENASE ETHE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43084:SF1">
        <property type="entry name" value="PERSULFIDE DIOXYGENASE ETHE1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="2">
        <location>
            <begin position="122"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM30272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="403" mass="45143" checksum="00BB9B3704C174B6" modified="2014-04-16" version="1">MISFKQQSSSIGWQWSSDLFRLSSRPIGTSMLANLRQLRHIQKATRTSVSHTAKSSRNVASIKGTVRQSQKGQTVHSWNRPFSPRSFSTPTKHLIPRQVTYSTASTIYTEPVIHDVFEPTSGTWQYLIADPSTSTAVIIDPVLNYDPATQAVTTHAADSLLSLIKGKGYTIDKILETHAHADHLTASSYLQKRLAQDQNLKPPICIGKRIEKVQRLFAERYGVPPVEYEGIFDVLFDDDETFTIGNLRGKAIHLPGHTPDHLGYMVGDNLFCGDSLFHVDIGTARCDFPGGDANDLFRSGRKLLSLPDHFKIWTGHDYPPEGRSDPVPWVSVQDHKKLNKHLKDGISEEEFVTLRKERDAGLAAPRLLHQSLQINIRAGRLPSPTNFGYRLLHLPLKLTGEAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W6QL82</accession>
    <name>W6QL82_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S06g000176</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792020">
        <property type="protein sequence ID" value="CDM37215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QL82"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM37215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="57" mass="6223" checksum="36F017E20FD699EF" modified="2014-04-16" version="1">MATSHGDVPSKADSWQTDISRLTALPSYVKKKKKGPNRDLNAGPRTGSPEARIIPNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W6QLG4</accession>
    <name>W6QLG4_PENRF</name>
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        <submittedName>
            <fullName evidence="7">Peptidoglycan-binding lysin domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PROQFM164_S06g000226</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792020">
        <property type="protein sequence ID" value="CDM37265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QLG4"/>
    <dbReference type="STRING" id="1365484.W6QLG4"/>
    <dbReference type="OMA" id="PGYYLCV"/>
    <dbReference type="OrthoDB" id="5985073at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="LysM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052210">
        <property type="entry name" value="LysM1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34997">
        <property type="entry name" value="AM15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34997:SF2">
        <property type="entry name" value="LYSM DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004881747" evidence="5">
        <location>
            <begin position="22"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="6">
        <location>
            <begin position="217"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="6">
        <location>
            <begin position="480"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="6">
        <location>
            <begin position="562"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="6">
        <location>
            <begin position="645"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="428"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="529"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="614"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="437"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM37265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="694" mass="73967" checksum="6C38FF6A285BF38F" modified="2014-04-16" version="1">MLLTSVGIAFVLPFFGQNVAAIQVWDSLDDIPTAVPSDCRNALTYNMTCANSLVTAQDAANGAALVGVAAKTYCTKECHDSLQTFQESILSACGKKEYQLYKNSTTTQSPAVVADGLVWAYSLMCIQDASGYCLADLYNRTKAPCSDCTLKYGSIMMSSDYGRNKFPPAAFSSLLSSCSVPASSYPYTYTPLPTATTMVSTPTGATSTTATPTCTGHTYISIEGDTCKSISKANSVSTDQLIKVNKLDYSCSMLISGTPLCIQDTCTVFTVQQNQTCNDIIKAQSFGLVQLIGWNPTIHQNCDNLDSMVGRSICISPPGGGEFSLPDSTNKTSAGLPSSLITSWVPGTPVTTMDNITTSWYSPIIDPNYTPSIPTFTPNATLSSLLAERTKYCWITAEDENNGFIPEDDLSDNCYSLYESYCDLGPTDPVPSPSPSAIPTSCTPTSSSASTTDSSPATTTTSGIATPTPTQPNMTKDCTKFHKVVDGDNCATISKEYGISQADFLTWNPDVGADCKNLWLDNYVCVGSTPTSTSGTPPPTSTSPGVVTPTPTQPNMTKGCTKFHMVVDGDNCATISREYGISRADFLTWNPDVGTNCTNLWLDNYVCVEASPSSNPSPTTTLSPSPTSEATPTPTLPKMVDGCIQFHKVEDGDICASIATQYGISQADFLAWNPYVGDGCKNLWLGYYVCVGKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W6QLN7</accession>
    <name>W6QLN7_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Citrate synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">mcsA</name>
        <name evidence="10" type="ORF">PROQFM164_S06g000306</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>oxaloacetate + acetyl-CoA + H2O = citrate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16845"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>propanoyl-CoA + oxaloacetate + H2O = (2S,3S)-2-methylcitrate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23780"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57392"/>
            <dbReference type="ChEBI" id="CHEBI:58853"/>
            <dbReference type="EC" id="2.3.3.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Organic acid metabolism; propanoate degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the citrate synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792020">
        <property type="protein sequence ID" value="CDM37345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QLN7"/>
    <dbReference type="STRING" id="1365484.W6QLN7"/>
    <dbReference type="OMA" id="IDHGFNA"/>
    <dbReference type="OrthoDB" id="8017587at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050440">
        <property type="term" value="F:2-methylcitrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036440">
        <property type="term" value="F:citrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.230.10:FF:000001">
        <property type="entry name" value="Citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.580.10:FF:000001">
        <property type="entry name" value="Citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.580.10">
        <property type="entry name" value="Citrate Synthase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.230.10">
        <property type="entry name" value="Cytochrome P450-Terp, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016142">
        <property type="entry name" value="Citrate_synth-like_lrg_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016143">
        <property type="entry name" value="Citrate_synth-like_sm_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002020">
        <property type="entry name" value="Citrate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019810">
        <property type="entry name" value="Citrate_synthase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036969">
        <property type="entry name" value="Citrate_synthase_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007128">
        <property type="entry name" value="PRK09569.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11739">
        <property type="entry name" value="CITRATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11739:SF15">
        <property type="entry name" value="CITRATE SYNTHASE 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00285">
        <property type="entry name" value="Citrate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00143">
        <property type="entry name" value="CITRTSNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48256">
        <property type="entry name" value="Citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00480">
        <property type="entry name" value="CITRATE_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDM37345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="466" mass="51174" checksum="B476BE251D75769D" modified="2014-04-16" version="1">MALSWRSTRHVSRLAQSARPVLSARHYATAEPDLKTTLKEVIPAKRELLKQVKAQSEEVIGEVKFANVIGGMRGLKAILWEGSVLDADEGIRFHGKTIKDCQKELPKGTTGTEMLPEAMFWLLLTGQVPSTGQVRAFSRELAEKSELPSYILDLIKTFPSSMHPMTQLSIAVAALNNESKFAKAYADGINKADYWEPTFDDSISLLAKIPRVAAIIFRPNDIDAVGTQKLDVTQDWAHNFAELLGKGGSDHADFHDLLRLYLALHGDHEGGNVSAHATHLVGSALSDPFLSYSAGLLGLAGPLHGLAAQEVLRWVTAMQDKIGTKFTDEDVRNYLWDTLKSGRVVPGYGHGVLRKPDPRFQALMDFAATRPDVLANPVFQLVKKNSEIAPGVLTEHGKTKNPYPNVDAASGVLFHHFGFQQPLYYTVAFGVSRALGPLSQLIWDRVLGMPIERPKSINLSGLLSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W6QLY4</accession>
    <name>W6QLY4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Type I phosphodiesterase/nucleotide pyrophosphatase/phosphate transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PROQFM164_S06g000427</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM164</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PIGG/PIGN/PIGO family. PIGO subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG792020">
        <property type="protein sequence ID" value="CDM37465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QLY4"/>
    <dbReference type="STRING" id="1365484.W6QLY4"/>
    <dbReference type="OMA" id="YPSFDIF"/>
    <dbReference type="OrthoDB" id="272139at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051377">
        <property type="term" value="F:mannose-ethanolamine phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16023">
        <property type="entry name" value="GPI_EPT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037675">
        <property type="entry name" value="PIG-O_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039524">
        <property type="entry name" value="PIGO/GPI13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23071:SF1">
        <property type="entry name" value="GPI ETHANOLAMINE PHOSPHATE TRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23071">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL GLYCAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="516"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="548"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="580"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="609"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="639"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="668"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="711"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="743"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="782"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="840"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="895"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="944"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1033"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDM37465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="1068" mass="116839" checksum="A2466ADC140CC6F7" modified="2014-04-16" version="1">MVTRPAGTMGTPNPSSPKSGLPAASPRSSEKSSGGQSKLKQAGLLDQKALELEDEFKVKHFGVMGVLAWILLLHVAGIYLFTKGFLLTRMVLENKSSCDILPFEDTLAQHTTALGSKQQKGCWHEKTFDKAVVIIIDALRYDFTVPFAPKGESDTAHLFHNNIPVLYETAVQNPANAFLLPFIADPPTTTLNRLKGLTTGTLPTFLDAGSNFAGTAIDEDNLVAQLHSAGKNLVHLGDDTWQALFPGYFDTNLTHAYDSFNVWDLHTVDNGVTEHLFPLLQPENRNKWDVIFGHYLGVDHAGHRYGPNHAAMASKLQEMDRVIRDIIAALDDNTLLVIMGDHGMDIKGDHGGESDDEVEAALWMYSKRGIFGRTRKDTLLPPQFARDRFVPQIDLVPTLSLLLGMPIPFNNLGSPIEEAFCGARGNNWANLATVNRLTAAQVKRYQHQYAIARGAGDDEEAALLWTAAEEEWRSAQKGFSSKSTAAQASNELYRKYQRHTLDICRGLWARFDVPSMIQGVVILFAGIILLIIYARGLKTDRTQATSRLLQFASVGAGVGAVAGSALGLTGLTEISTVDGAVLLAAAGSIIGATPALVKKPANMTLPLPNGMWGWLALFFTVSQSIGFASNSYTIWEDEILLFFLTTFAVCAGISSMRQKQTTDRILGVYHSILFVILGRIASFSRLCREEQMPFCRSTYYASSTSSTSAPWQLAIPFLVTLFLPSVVRSYYAGSKSYQGVASLWIGFAFRFGLFVASIFWILEGADDGEWLPVSKETLKFARVFLAQFVLALAFAAGTAAYLYSKPCVSINVSKPTEDPNSPPAPIVAGQQQGPRTTVTILGFGNVYGTHFCFLLINFALAVILMQKPMGQGAIALLLWQILSLLEILDTNGLTMSNSSIGPVILGVLGSFYYFKTGHQATLSSIQWETAFIPLTTIQYPWSPLLVILNTFGAQILAAIAVPLTVLWKRPLQTHDRVPASNPNKNPATRILSDVVQAAGTHILYLATINLATTMWAGHLRRHLMLYRIFSPRFMMGSVVLVVVDVVLMVVSVGGVRWNTLSVGEIFGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W6QM86</accession>
    <name>W6QM86_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S08g000014</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792022">
        <property type="protein sequence ID" value="CDM37963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QM86"/>
    <dbReference type="STRING" id="1365484.W6QM86"/>
    <dbReference type="OMA" id="SEPYIWV"/>
    <dbReference type="OrthoDB" id="3009558at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM37963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="530" mass="59713" checksum="5FD4DB8EB8C0AA1B" modified="2014-04-16" version="1">MATYSCVQEHPRPVSQIIQYRGRQLRQVHRTTSTLWGSRSVAEARALIEPQITQENEQLFRTYHPAFSSQRAVCVLTQKDSGKDIWVVPENSHVPFIKAGGREIHIQPAFESPVDHDMQYCNIISDPIRRDVDVRQAFTPEDIKCLRAAFPRSIGAFIYQVECVVILFSRRDDMLHTWNFGTPPTVGRLTVGYTVLAMQPSAATAESGQQLARMSNAYEVCGVLGLKIRLPDHTEAITVPTHAFVRLPGPPTFFTRVASFYKRVTQSLTRFQIPLRLQNREVEVSTTPSPLSSSPIGKQCWLAGTNRRVGLITRTYDDPSSTYPYPSGYRHDLSLITGDNLIDIHPPKGIEMVPEWASYKDAIQGAPMIACVFDYINNEHGRLLGDIPNEQIRAALLEGHGHIWIQNAVDSSASILWRTDEDQVDARGFSGSVLCIGRVHEKCRPLLFQNFQLKITVWPDGECQRNSADLPPGLNHPNPMIKGGFILPDEIRTAKILLRSVRRQRQNLSDPVSSEIDQTVPNRKQFSDPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W6QMB0</accession>
    <name>W6QMB0_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein BNI4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S08g000044</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792022">
        <property type="protein sequence ID" value="CDM37993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QMB0"/>
    <dbReference type="STRING" id="1365484.W6QMB0"/>
    <dbReference type="OMA" id="EINNFKM"/>
    <dbReference type="OrthoDB" id="5563016at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12751:SF18">
        <property type="entry name" value="PHOSPHATASE AND ACTIN REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12751">
        <property type="entry name" value="PHOSPHATASE AND ACTIN REGULATOR PHACTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="554"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="595"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="23"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="121"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="216"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="258"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="288"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="344"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="366"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM37993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="727" mass="78436" checksum="433DBD782C95D739" modified="2014-04-16" version="1">MAALVQTIPQQSGTVPVLQTRPSSSSGTFSSSTQNQGSRIQTMSWTSFNAGNSGTYRAGHPVVAPYAYNPNMGQSVQNRQSWTPHLRPEHRTFSAPTTPQVPVNPTYTGASPRSSHPAAGSVSNPSNSSSRSYVSKDDSALPSRPRSDQPLRPLSTANLPSPPIMNISSPKPSPNRYRRTPQRAEAAPSSPAPSPIPTVIVDDFGGPRPVRPSAHSRVSSVDDSSYVDRAQPERYRRRSLGNMDAAAYPNLPLDFPTSPSSQPQSGSYDFITFDANQRPASSHSQRDSVGSVNSTHSSASSAREGTPSESNSVTSKTGKAEEKRTSKPSPLSQPVSTEPEAPKPKPPAEAPKKPPPPTLDSPAAKRLNDLKMDTKRPGKSRLRRAFSFGSASELLKTSAQSNASKREAFAADQARREALREQLGPEQAAIAEQQELSGLGESIYSHQGHFFTGSNDNLSVSSTASSASMMLRKMGKGMKRSTRSLVGMFRPKSVASINSMEGAIPEIPAPQITVVNVEAERERVAVNPDPADLPRGATVFPKVDNASEVRRSVSIRERAASENSQSRKSIMGGDRERAEILAAVRKGILKKTHSDFGVSSPAHALPGSDSPHSSAPPTPDESSRSPAHQNDPVKIAGEDYFLSARFSSSEAKSAPITPSNVAGRNIVFSPRIQFHETWPSGEYDRRGEIATCNRLTPLLAQQIREEINNFKMEMEVHENSKIYTHFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W6QMD0</accession>
    <name>W6QMD0_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein kinase-like domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S04g000215</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QMD0"/>
    <dbReference type="STRING" id="1365484.W6QMD0"/>
    <dbReference type="OMA" id="PRNILME"/>
    <dbReference type="OrthoDB" id="8300194at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF58">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="94"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM35334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="178" mass="20907" checksum="41DCDE465ADC6A5B" modified="2014-04-16" version="1">MVYMPGKPLDKAWDTLSSSQKLSIANKLYSYLKQLRELKGHYIRAINWGKAIIGRIASIEGGPFDTEAQFNEFILGDFVKIAPDMLRHYTKFALMDDHEIVFTHSDFAPRNILMEAGRVTAILDWEYAGWYPAHWEYCQALRQLRPMFDWPEYLARILPPKFEREYIGMTFLARISRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W6QMS6</accession>
    <name>W6QMS6_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Elongated TPR repeat-containing domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PROQFM164_S07g000068</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792021">
        <property type="protein sequence ID" value="CDM37720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QMS6"/>
    <dbReference type="STRING" id="1365484.W6QMS6"/>
    <dbReference type="OMA" id="WRAAQCA"/>
    <dbReference type="OrthoDB" id="420195at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21381">
        <property type="entry name" value="CTWD_TTC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044059">
        <property type="entry name" value="Csn1/TTC4_wheel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46035">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46035:SF1">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18972">
        <property type="entry name" value="Wheel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="Cns1/TTC4 wheel" evidence="5">
        <location>
            <begin position="295"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="234"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF18972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDM37720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="411" mass="45579" checksum="99EF34179E705277" modified="2014-04-16" version="1">MSRVEELPDDFDESLNLNKAPPEVTQGVPVPGFDAFAANETPFPINEEALKARNTDPNAPELPPAIAAIQSHSSEELMAMMNKTPLFMTDIDKAGDEKGENVLLDALQALQNEGTRGEVANSFKGQGNEAVQGLKWIDAKEFYTKALAVINAKENKWEAPEDFEEEAALLRKLEEASYINRALCNLELGMKLPFLYPRLRFHPQVKPQKLAEAEDSAARGLAIDPESKALLESAKKIAERKALLERAAARKKAEEERVRKQNMVLSAALRARQIRTRKTAQPPDIEDAGIRLVPDPLSPESTIEFPVVFLYPMDAQSDFVKAFSEMNAIEDHLSYIFPLPWDKKKEYTVEGVECFMQTVSGGLIKAGKKLPLLQILSGGKVEVVDELVTIHVVPISKTGKYIAEMKARKTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>W6QN70</accession>
    <name>W6QN70_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein transport protein sec16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">sec16</name>
        <name evidence="15" type="ORF">PROQFM164_S06g000363</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Involved in the initiation of assembly of the COPII coat required for the formation of transport vesicles from the endoplasmic reticulum (ER) and the selection of cargo molecules. Also involved in autophagy.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the SEC16 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792020">
        <property type="protein sequence ID" value="CDM37401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1365484.W6QN70"/>
    <dbReference type="OMA" id="YKSPYDL"/>
    <dbReference type="OrthoDB" id="8918678at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070973">
        <property type="term" value="P:protein localization to endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09233">
        <property type="entry name" value="ACE1-Sec16-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.1030:FF:000008">
        <property type="entry name" value="Protein transport protein sec16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024340">
        <property type="entry name" value="Sec16_CCD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024468">
        <property type="entry name" value="Sec16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024298">
        <property type="entry name" value="Sec16_Sec23-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13402">
        <property type="entry name" value="RGPR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13402:SF6">
        <property type="entry name" value="SECRETORY 16, ISOFORM I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12932">
        <property type="entry name" value="Sec16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12935">
        <property type="entry name" value="Sec16_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12931">
        <property type="entry name" value="TPR_Sec16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0072">Autophagy</keyword>
    <keyword evidence="4 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 10" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Sec16 N-terminal" evidence="14">
        <location>
            <begin position="367"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="domain" description="Sec16 central conserved" evidence="13">
        <location>
            <begin position="1068"/>
            <end position="1185"/>
        </location>
    </feature>
    <feature type="domain" description="Sec16 Sec23-binding" evidence="12">
        <location>
            <begin position="1246"/>
            <end position="1543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="179"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="660"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="703"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1545"/>
            <end position="1570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1600"/>
            <end position="1680"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1702"/>
            <end position="1861"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1874"/>
            <end position="2012"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="202"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="749"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="820"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="847"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="962"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1600"/>
            <end position="1610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1640"/>
            <end position="1654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1655"/>
            <end position="1669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1732"/>
            <end position="1759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1774"/>
            <end position="1787"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1805"/>
            <end position="1825"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="1911"/>
            <end position="1920"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="1960"/>
            <end position="1973"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF12931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF12932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF12935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CDM37401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="2012" mass="214711" checksum="D713BCE6D0ABDCE6" modified="2014-04-16" version="1">MAHQATENDSESWNPASRPDNNNSPVTIQSGLSDPIAADGPKDRSLDDVVSPQSEDFSAWDISDEVDGIQPQYTSLDVLVNNESPVVDQDMCLDTDSVDKSSHVPDETIAATHTTTPSIENADTVLSQTLPETQPAQPVQIEAPSVHGAETSNSFPTIINGFPSVHTENSDTVVPTVAPEQETAPESTFVGETTPPREETTASEPTLDTSKNKYTSQSTPTDELFPGTDADNADSENPWATFEKDLSNTLPSTEEATPHNISELASTSTQIQDSDEPNFVEEAVRPLPEETAFTGATRDAESLDVFNSTENAIAPTENEQIDLVSHSINVESGNTGSPSPIAEAFAPTNDAHLDPAAAGVDTTTQDQPFWANESSGEVESDEDGFFDQLNSQTKPIFAPPEAESRFEEGVPLLDESTPASPQHPTEQETSIDSVFANDEDDVDDFFISAPKTEAKNADEDFFASTPKKEPEEQPVVHIARKSTSQVLESAGFALDSPVSDTSAAAQFDDALKAASLEPQTMADPSEEELAARWEAELGDSLDDDLAARWEAALDDDDILLETEAAQSVSEQEHAHQTPVQPVNDGLVVGLNSPFQTPQVFSQPRPVPNIYTPHQPSTGDLLQNIPLPGTAPPTTGAMSSYFSQQPQNPVAIRGESFAERSKEGYKSPYDLPDDISRPRKPVVTHKPVPPPVISMPPPPLPCASGIPIPAVAGFPPPAAPPSALAAPPAPKNFYEELPLPPPRSRPASSGRYTPNPQTAPTMTGSSLPPPQVQYASVVPPAPQPIGLPIQSTLQPPEQLDPYASLSSSAPVGPPTVARYSPQPPGFQAPPKPPSLPRYSPAPPPTSSVRNRYASQPLNVPGQNLPFQPRTSSPLAHHEKVSYQPDQSHRPPSLEPAINLSSPREQGAGFGQIPPSAPQYFNGPANLPRRESAGSPLQPSPPQSRYAPQEYLNEFAQRLAPGPEHAPPAPPAPPANGLSPPPSDFQMGPLRRSQTQSPARDLTSPRSYGQDIDPLQRPASVQVSSLPIQTVNPYAPVKPVHQTRAPTHHLEFIAPNDGQEHDPLERWKGAPIFKFGFGGSMVSCFPKHVPRYSIGQVAPMIQPTLGEPKISQLSEWLPSADTIVQHPGPLKAKSKKKDLVAWLSSKIAAFENSDLPSYEQVQSDTHKRQEEKTLLWKVVKLLVENDGNLESSPEIQTSLRHIIFPNLPNSDADGSYASSLAPSGGVAPSETPLQADAVDAQWLEELRLHLICGDREKAVWSAVDRRLWGHAMIISSTMDRSISKQVAQEFVRREVRSKSANTESLAALYEIFAGNIEESIDELVAPSARAGLQLISMANGQGSTKNALEGLDKWRDTLGLVLSNRSPGDHQALFSLGHLLSSYGRTEAAHVCYIFSRAAVFGGPDDPQANITLLGADHQRCPSSLMDEDAILLTEAYEFAMSVLGNSPTAHLPHLLAFKILNARCLVDQGRNLEAQGYCDAVAAALKATTRPSPYYHQHLFAEVEELSARLRQTTSDSGSWISRPSMEKVSGSMWARFNSFVVGDDSDAASTGSGKGGEHAEFGPFANVAGTPTISRSPSVSEIYGSYPGAAAGAPLIPTSGASKYHPSSQYAPGASPEQFKGRSSIDSQRSASYFPPYGQRRSSQELSPSIDQQMSYGAPGYGSPSAGGYQPTPPQSSYIPLAPVEEATSPAEAHPAAQSMVNGLFYHPPGQAATSSQSPYYQGPPGMPASVPDSESPYAPPAASSSYEPVSYEPNSYEPAAAGVDMGYGSQEEDLPRAAEQPRKQSIMDDDDDDLAARAAAIQKAENDRKANEAFAKAAEEDAKKGPQQSGKKGWFGGWFGGAKKEENSGGGPIRAKLGEESSFYYDKELKKWVNKKDPGSSAPVHATPPPPRRSAPPSRTASSNSMPQNGAPPMPPMPPMSVSGGRPQSSSTAAPPFLSPSPGFPGLAPRSVSTGAAMPTPPGSSSGPPPRPSSSLTHASSIDDLIGAPQARKGSAVRGKKKGRYVDVMAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>W6QNE7</accession>
    <name>W6QNE7_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="8">G2/mitotic-specific cyclin cig1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">cig1</name>
        <name evidence="8" type="ORF">PROQFM164_S02g001322</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclin family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QNE7"/>
    <dbReference type="STRING" id="1365484.W6QNE7"/>
    <dbReference type="OMA" id="MVDGAYT"/>
    <dbReference type="OrthoDB" id="5590282at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044772">
        <property type="term" value="P:mitotic cell cycle phase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20512">
        <property type="entry name" value="CYCLIN_CLBs_yeast_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000001">
        <property type="entry name" value="G2/mitotic-specific cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039361">
        <property type="entry name" value="Cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004367">
        <property type="entry name" value="Cyclin_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048258">
        <property type="entry name" value="Cyclins_cyclin-box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10177">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02984">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01332">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00292">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="2 4" id="KW-0195">Cyclin</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="6">
        <location>
            <begin position="321"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin C-terminal" evidence="7">
        <location>
            <begin position="414"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="6">
        <location>
            <begin position="418"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM31172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="555" mass="62464" checksum="88C537AE7FE4330E" modified="2014-04-16" version="1">MDAKPQRFRVVGDENVPPSSLHQNHKVIHQRNKSSPALSMMAQNNAGRRAFVDVSNTKDMNRASRDDSAVGGKPALVEVKAPGLSQPAQRRMTLAGTKGVIESVATTKPMNPAGKAQPAYKSKRNNAVFKDQLHTVPEKTASKETNTDTDAKTSHKGVEKGRHLNSIVVRPSNVLNVDTASLVESDATVSETEDLKEYTYTYVKEPVPAVSEPEEWDGDDTEYNVAPFYSFRGDNADGTTVIYPCMSNVTTREMFRAKDIVESEQTPEDIEEELLDTTMVAEYGDEIFLHLRKKEIEMLPVPDYMARQSELQWSMRAVLMDWLVQVHGRFNLLPETLFLTVNYIDRFLSYKVVSMGKLQLVGATAIFIAAKFEEITAPSVQEIVYMVDGGYSVDEILKAERFMLTILDFDLGWPGPMSFLRRISKADEYDLETRTVAKYFLELAIMDERFVCTPPSFIAAGAHCLSRMLLNKGNWTPAHAFYSGYLYSQLIPVLVTLMECCENPRRHHAAIFEKYSDRRFKHASIFVETGLASDFVLPEPSDLNDPDRLDGYANY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W6QP86</accession>
    <name>W6QP86_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Peptidoglycan-binding Lysin subgroup</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PROQFM164_S07g000139</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792021">
        <property type="protein sequence ID" value="CDM37791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QP86"/>
    <dbReference type="STRING" id="1365484.W6QP86"/>
    <dbReference type="OMA" id="SKCCAFW"/>
    <dbReference type="OrthoDB" id="73875at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036861">
        <property type="entry name" value="Endochitinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053214">
        <property type="entry name" value="LysM12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057277">
        <property type="entry name" value="LysM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47700:SF2">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47700">
        <property type="entry name" value="V CHITINASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G13720)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25139">
        <property type="entry name" value="LysM14_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57016">
        <property type="entry name" value="Plant lectins/antimicrobial peptides"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004882220" evidence="4">
        <location>
            <begin position="22"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="5">
        <location>
            <begin position="33"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="148"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="175"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDM37791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="362" mass="39174" checksum="DCEAA81672DF2037" modified="2014-04-16" version="1">MGLFRIDFLALWLLFLRLATAAVPVPTSDGYCFVYLIQGYDTCALIAKAHGITEADIESFNKNTWAWLGCGRLYQGDFICLSAGKPPMPMALPHATCGPQVPGTTRPAKWADLPGLNPCAESKCCAFWGQCGVSDLYCEGYRAPPAGPTATVKGATEAPTSEVTTKAKATGVQQSTKTGAGSKATSKSSTSSKSSTTGTTIIKATKITTTTKQTTTQKTTTQAAPKASASQYSWTAPWEITLYSQANCQGDYYHLEGYNKEYLDDKGCLALHGGLNSKFTETGVTCKWWTSNSLTWTSCDASKLVKPESWLLKNGYCSIFTKTDCDCFDTWKLYYQPKGCHNRTEGIDPPTFAALECSINGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W6QQ12</accession>
    <name>W6QQ12_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S08g000132</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792022">
        <property type="protein sequence ID" value="CDM38081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QQ12"/>
    <dbReference type="OrthoDB" id="4369213at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM38081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="82" mass="8630" checksum="C409407DA8EDC3C0" modified="2014-04-16" version="1">MRSRSPPSPLSSAINQVLKACQITMQSAAFLEKEIPADEGLSVQEASQLITELVEASEAPPPPHARKPSTGGRTTSTGCIKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W6QQ69</accession>
    <name>W6QQ69_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Zinc finger, DNL-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PROQFM164_S05g000037</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QQ69"/>
    <dbReference type="STRING" id="1365484.W6QQ69"/>
    <dbReference type="OMA" id="YRITFTC"/>
    <dbReference type="OrthoDB" id="512667at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050821">
        <property type="term" value="P:protein stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024158">
        <property type="entry name" value="Mt_import_TIM15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007853">
        <property type="entry name" value="Znf_DNL-typ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20922">
        <property type="entry name" value="DNL-TYPE ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20922:SF13">
        <property type="entry name" value="DNL-TYPE ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05180">
        <property type="entry name" value="zf-DNL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51501">
        <property type="entry name" value="ZF_DNL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DNL-type" evidence="6">
        <location>
            <begin position="97"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="64"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="74"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM36204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="204" mass="23211" checksum="36FB8E829F6D71D3" modified="2014-04-16" version="1">MRPFTPGLRPLNALLSQAQSYTTVARIQSSRFLSTQSFSLNSARPSSLLPRSQRIFLQTQIRYNSRAPHPLTESPKTPKSQAEQEAEWEARNQERRKDEEAYRITFTCKPCGHRSSHRMSKQGYHRGTVLIQCPECDSRHVMSDHLGVFFDKKTTLEDLLKEKGQTLTHGHTEGNLEFWEDGSVKSYDLEGKEILGASDEGKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W6QQH8</accession>
    <name>W6QQH8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Intradiol ring-cleavage dioxygenase, core</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PROQFM164_S02g001928</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM164</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the intradiol ring-cleavage dioxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QQH8"/>
    <dbReference type="STRING" id="1365484.W6QQH8"/>
    <dbReference type="OMA" id="FYCYHPT"/>
    <dbReference type="OrthoDB" id="5238185at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018576">
        <property type="term" value="F:catechol 1,2-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009712">
        <property type="term" value="P:catechol-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.130.10">
        <property type="entry name" value="Aromatic compound dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007535">
        <property type="entry name" value="Catechol_dOase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000627">
        <property type="entry name" value="Intradiol_dOase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015889">
        <property type="entry name" value="Intradiol_dOase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050770">
        <property type="entry name" value="Intradiol_RC_Dioxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33711">
        <property type="entry name" value="DIOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G02910)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33711:SF5">
        <property type="entry name" value="INTRADIOL RING-CLEAVAGE DIOXYGENASE PRCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00775">
        <property type="entry name" value="Dioxygenase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04444">
        <property type="entry name" value="Dioxygenase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49482">
        <property type="entry name" value="Aromatic compound dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Catechol dioxygenase N-terminal" evidence="9">
        <location>
            <begin position="25"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="Intradiol ring-cleavage dioxygenases" evidence="8">
        <location>
            <begin position="107"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="288"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="302"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDM31777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="316" mass="35014" checksum="F199F82B880D6189" modified="2014-04-16" version="1">MSSTRQFDPNFTPSVINGMGPNTPERARVVLGSLIKHIHDFAREVELTSAEWMLGVEFINSIGQISTPIRNEGHRICDVIGLESLVDEIANKIITEDGLSPTSNVILGPFWSPNAPFRALGDSIIQDPKPNGRVTFMHGAITDMETGKPIVGAVLDIWQASANGQYDFQDPTQTDNNLRGKFRSNEKGEFNWYCYHPTPYSLPTDGPAGVLLNLMDRSPMRPAHIHLMITHPDYATVINQIYPSDDPHLAIDSVFAVKDDLVVDFKPKTNDPKASLDLEYNVRMALKKHHPNPNSAPPVSSFERHAKAAKEAQGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>W6QQK2</accession>
    <name>W6QQK2_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Zinc finger, RanBP2-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PROQFM164_S02g001963</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </subcellularLocation>
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        </source>
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</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W6QSA4</accession>
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        <submittedName>
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    </gene>
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            <taxon>Pezizomycotina</taxon>
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        </lineage>
    </organism>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
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                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
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        <property type="project" value="UniProtKB-KW"/>
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    <keyword evidence="2" id="KW-0418">Kinase</keyword>
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</entry>
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    <accession>W6QSP6</accession>
    <name>W6QSP6_PENRF</name>
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        <submittedName>
            <fullName evidence="7">Cytochrome P450</fullName>
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    </protein>
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        <name evidence="7" type="ORF">PROQFM164_S02g002663</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
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        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="1365484.W6QSP6"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002974">
        <property type="entry name" value="Cyt_P450_E_CYP52_ascomycetes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047146">
        <property type="entry name" value="Cyt_P450_E_CYP52_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287:SF18">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE APDE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01239">
        <property type="entry name" value="EP450IICYP52"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM32512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="220" mass="25522" checksum="5B6F941762AAC3B8" modified="2014-04-16" version="1">MICRRDSIWGSQKGCELPLELPKRWPFGIDRIKDLWETNAEGRLLAYLCKIAEDYEPQNNLTQYLLFGPRAFHVLHPKNLEVVFIGSFAHWCFFFLSDYGFGVRPQIFAPLLGNGIFTQEGFEWQHSRELLHKQFKNVQSQNFDQFREHVDNLIDRLPSSGGVDLQPPFFDLTMDIATALLFGRSVYTLRAGIDQYQHNKLFAESFNIAQEGLAKRFTLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W6QTK6</accession>
    <name>W6QTK6_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Short-chain dehydrogenase/reductase SDR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PROQFM164_S02g003023</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QTK6"/>
    <dbReference type="STRING" id="1365484.W6QTK6"/>
    <dbReference type="OMA" id="TDIEHGW"/>
    <dbReference type="OrthoDB" id="3819888at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052178">
        <property type="entry name" value="Sec_Metab_Biosynth_SDR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618">
        <property type="entry name" value="7-ALPHA-HYDROXYSTEROID DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618:SF4">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_7G04540)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="230"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="235"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDM32872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="295" mass="32012" checksum="EA4E5E2F0A880345" modified="2014-04-16" version="1">MSAQESNRSFKLEHLFGLKNRVALVTGGGSGIGLMATQALAVNGAKVYITGRTEEKLDRVADLYSKDIPGQIVPITADITSKESIQKLVDEISAKESKLHILINAAGISSPHLNTDQDNPKALQEELFKNQSTIQEWEDVMRTNVTHLFFTTTAFLPLLSKGSEDEYGWSSTVVNISSISGLLKTAQRHFAYNASKAAAIHLTKMLAYEIVSSQIKIRVNSIAPGVFPTEMTAHGSDKKQKSTIPKERFEGKIPAGRPGKDEDMATAVLFTVSNQYLNGQTIAVDGGYLLATGTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W6QU07</accession>
    <name>W6QU07_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S02g003173</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM33022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QU07"/>
    <dbReference type="STRING" id="1365484.W6QU07"/>
    <dbReference type="OMA" id="GKTGRNW"/>
    <dbReference type="OrthoDB" id="1162399at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="350"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="409"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="366"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="449"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="484"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="536"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="564"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM33022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="584" mass="66196" checksum="7F4B6CEEED7D1FBC" modified="2014-04-16" version="1">MSYFKTEYQRFLDNPKAAKLADDVSLIYVPTTTKFEKSDNVITHVLKNAKVVKTKSNKVISAIEGSDSLCLDMETTLEFTEGGGVYLPSLDDNFLADRVATFPTIHIVHFDTNQQIKQIRIYWDQASLLKQIEVIGARGRQWPIRDGKDQLRLLRDAETARGTPSQPSSQKLDTDLPHRPSSSGKRRIKDPYAADSLTELISPVKEVAEPESGAKTPSRPSTAKKYTPDPYGAGSLTELLSPTKKVRAPVAPFAPSAGRPAERNFSDIFVKDDHVPDSRTGPVDEHRHYYKAVPGKYDHFEIGGDNSEREAKAEVRQANTKHETHWDFNDVETPVKGQRVLRGQEVRHFGFGDDEEGAGSPQTKQDVAKPRRDADRHFDMTDSESADEGRIISSFGGRGKRLYENRLFDDNGQPQLSEREQKDEPLPTGGNVANRKKNFASQFDLTDESPVKENKPTQRHDAHNKMMESHWDNYDEQTPPKPTQNHDKHNKAMESHWGNYDEPSPPHPTQQHHAHNKMMESHWDNYDEPTPPKPTQNHDKHNKMMEPHWGNFDDASPEPVRRNATAQRNPLGHNQPSWNHGDNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W6QU76</accession>
    <name>W6QU76_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Aflatoxin biosynthesis regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PROQFM164_S07g000032</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792021">
        <property type="protein sequence ID" value="CDM37684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QU76"/>
    <dbReference type="STRING" id="1365484.W6QU76"/>
    <dbReference type="OMA" id="PPCSNCI"/>
    <dbReference type="OrthoDB" id="5295362at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053157">
        <property type="entry name" value="Sterol_Uptake_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47784">
        <property type="entry name" value="STEROL UPTAKE CONTROL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47784:SF10">
        <property type="entry name" value="TRANSCRIPTION FACTOR, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14150)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00755">
        <property type="entry name" value="AFLATOXINBRP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="13"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDM37684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="383" mass="42792" checksum="A06961534CDA82E4" modified="2014-04-16" version="1">MPPRRAHTKSRQGCDQCKRRRVKCDEKGPPCSNCISRELPCTYLRAPARPDSRASQTPAPLAIIDTPLRPRIPRLTAPVSSTISAVRDLELMHKFSTETYKSLCSSSSEHYVWQIAIPRLALQYDFLMNGILALGALHIAATIEPPASLVYIDIALQYHNLTFAPYRAAVDSINPMNCEAALAQSIITTVIGIALPRVTAARGESSSITENIVVVFELLQGVRKIHRIGESWIKLELFTRRRNYWNSGVASIDSDMRDALERLGSLNDEALASIDPDQHQVNKDAIVYLRHFSARVGNSVDAANVLAWLAMSDKEFVDNVRRRQPLSLLILMHWGVLLGELDGQHWWARDSGRALVSELLDALHPGDMEWANAMAWARKKMGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W6QUB7</accession>
    <name>W6QUB7_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peroxidase</fullName>
            <ecNumber evidence="8">1.11.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PROQFM164_S07g000072</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Destroys radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peroxidase family. Cytochrome c peroxidase subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.-" evidence="8"/>
    <dbReference type="EMBL" id="HG792021">
        <property type="protein sequence ID" value="CDM37724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QUB7"/>
    <dbReference type="STRING" id="1365484.W6QUB7"/>
    <dbReference type="OMA" id="GAWVNNP"/>
    <dbReference type="OrthoDB" id="2859658at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000302">
        <property type="term" value="P:response to reactive oxygen species"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00691">
        <property type="entry name" value="ascorbate_peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.420.10:FF:000009">
        <property type="entry name" value="Ascorbate peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.520.10:FF:000005">
        <property type="entry name" value="Cytochrome c peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.420.10">
        <property type="entry name" value="Peroxidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044831">
        <property type="entry name" value="Ccp1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002016">
        <property type="entry name" value="Haem_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002207">
        <property type="entry name" value="Peroxidase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019794">
        <property type="entry name" value="Peroxidases_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31356:SF36">
        <property type="entry name" value="L-ASCORBATE PEROXIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31356">
        <property type="entry name" value="THYLAKOID LUMENAL 29 KDA PROTEIN, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00141">
        <property type="entry name" value="peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00459">
        <property type="entry name" value="ASPEROXIDASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00458">
        <property type="entry name" value="PEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00436">
        <property type="entry name" value="PEROXIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50873">
        <property type="entry name" value="PEROXIDASE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 8 11" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Plant heme peroxidase family profile" evidence="10">
        <location>
            <begin position="13"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="279"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDM37724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="304" mass="33473" checksum="067406992DFA20F1" modified="2014-04-16" version="1">MSTHDYDAVRKDIADILQKPGYDDGSAGPVFVRLAWHSSGTYDVESDTGGSNGAGMRYEAEGGDPANAGLQHGRAFLEPIKEKHPWITYSDLWTLAGVVAIKELGGPDIPWQGGRTDLINDTKLPPRGRLPDGAQGADHLRFIFYRMGFNDQEIVALTGGHNLGRCHGDRSGFEGPWVTNPTRFSNSFFKLLLQLDWQPRKVASGNTQFVYVDPDADEDEEPLMMLPTDMALMTDPAFAPWVKRYAKDKELFFDHFSKVFAKLIELGIRRDAQGAVTNTDGTLGGYVSAPKKSNTATGPPRARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W6QV70</accession>
    <name>W6QV70_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="4">1-aminocyclopropane-1-carboxylate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S03g000181</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QV70"/>
    <dbReference type="STRING" id="1365484.W6QV70"/>
    <dbReference type="OMA" id="SKSYNMG"/>
    <dbReference type="OrthoDB" id="7042322at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43510">
        <property type="entry name" value="AMINOTRANSFERASE FUNCTION, HYPOTHETICAL (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43510:SF1">
        <property type="entry name" value="AMINOTRANSFERASE FUNCTION, HYPOTHETICAL (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="3">
        <location>
            <begin position="45"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM33457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="408" mass="45310" checksum="D22F1554A32EE186" modified="2014-04-16" version="1">MVKIEAFAVEQWMDKYETTAKYNTAETCCASISVDDLRALSDDKESNPLAQLQSTKLTYGAIRGSDKLRNTLANLYSVRAPTQLPKENILITAGAIQANFLLLYTLVGPGDHVICHYPTYQQLFSVPASVGAEVSLWKSKEADGWQLDIEELKGLIRPNTKLIIINNPQNPTGAIIPRQTLQQLVDIAREKSIIIHSDEVYRPLFHNISPADPRFPPTLLSMGYERTVVTGSVSKAYSLAGLRVGWVASRDSSIIESVANTRDYTTISVGKIDEAIAGFALAPHCIHNLLKRNIDLARTNLSILEKFIDAHRWACEWIKPQAGTTAFVRFNKMGKPVDDVAFCEMLQERTGVMLVPGSLCFGVGEDFKGYVRIGYVNETEVLERGLDALGKFMEDGYEDVPVKKPLQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W6QWJ5</accession>
    <name>W6QWJ5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S14g000028</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792028">
        <property type="protein sequence ID" value="CDM38529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QWJ5"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM38529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="125" mass="13822" checksum="D1A204C9ED5D87D8" modified="2014-04-16" version="1">MILEEDTEVLLRRAWLLQIAAAPGVRPLHSIGRDKDTRLLDYFAAFIQQNMFTTSFSSIVPDLTPLISTSPVLYDVVIAIGTLYANRCTGGHALQGEKSSYVHAMTSYHKSMGFLRTSLGNSNVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W6QWN0</accession>
    <name>W6QWN0_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Probable phosphoketolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PROQFM164_S03g000661</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the XFP family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QWN0"/>
    <dbReference type="STRING" id="1365484.W6QWN0"/>
    <dbReference type="OMA" id="GCMDDRE"/>
    <dbReference type="OrthoDB" id="2532903at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016832">
        <property type="term" value="F:aldehyde-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005593">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018969">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019790">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018970">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019789">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase_ThDP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31273">
        <property type="entry name" value="PHOSPHOKETOLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31273:SF1">
        <property type="entry name" value="PHOSPHOKETOLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03894">
        <property type="entry name" value="XFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09363">
        <property type="entry name" value="XFP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09364">
        <property type="entry name" value="XFP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017245">
        <property type="entry name" value="Phosphoketolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="TK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS60002">
        <property type="entry name" value="PHOSPHOKETOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS60003">
        <property type="entry name" value="PHOSPHOKETOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase N-terminal" evidence="6">
        <location>
            <begin position="34"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase C-terminal" evidence="5">
        <location>
            <begin position="599"/>
            <end position="802"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF09363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF09364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM33937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="819" mass="91973" checksum="6412F12EF09EDCB8" modified="2014-04-16" version="1">MPAEIIDQPNPAALPSYLPDYLEKLSVKLDHEKLDEKACDALLKFRRAACYIAAAMIFLQENTLLKSELTPHDIKPRLLGHWGTCPGLILVYSHLNYLIRTRNLDMLYVVGPGHGAPAILAALWLEGSLERFYPEYSRDSKGLHKLISSFSTTAGFPSHINAETPGAIHEGGELGYALAVSFGAVMDNPDLIVPCIVGDGEAETGATATSWHAIKYIDPKESGAVLPILHLNGFKISERTIFGCMDHKELVALFSGYGYQVRFVEDLNNIDADLHFSMTWAIEEIQRIQKAARSGKPIMKPRWPMLILRTPKGWSGPKEVHGMFLEGSFHSHQVPLPKAKTDKEQLDLLQKWLSSYKPDELFTSTGDVIDEIKSVIPTEDKKKLGQRIEAYNGYKRPNLPDWRPFCVEKGSDASAMKVIGSFINQTFKDNPTNVRLFSPDELESNKLDEVFEGTNRNFQWDQFSNARGGRVIEILSEHMCQGFLQGYTLTGRIGIFPSYESFLGIIHTMMVQYAKFTKMALETTWHTSVSSINYIESSTWTRQEHNGFSHQNPSFIGSVLKLKPTAARVYLPPDANTFLTTVHHCLKSRNYVNLMVGSKQPTPVYLTPKEAESHCRAGASIWKFCSTDEGINPDVVLVGIGVEVMFEVIAAAALLRKLIPELRVCVINVTDLMILENQGLHPHALSTEAFDSLFTADKPIHFNYHGYPTELQGLLFGRPRLERVTVAGYIEEGSTTTPFDMMLLNRVSRYHVAQHAIHGAAKGNEKIRVYQQELNAQLEGSIVNTRRYIVANRDDPPGIYDTPQFHNFHKPAEPFWDLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W6QX51</accession>
    <name>W6QX51_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aegerolysin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S03g000841</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aegerolysin family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QX51"/>
    <dbReference type="STRING" id="1365484.W6QX51"/>
    <dbReference type="OMA" id="SIHIRDR"/>
    <dbReference type="OrthoDB" id="2727348at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019836">
        <property type="term" value="P:symbiont-mediated hemolysis of host erythrocyte"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.270.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009413">
        <property type="entry name" value="Aegerolysin-typ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06355">
        <property type="entry name" value="Aegerolysin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM34117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="137" mass="15565" checksum="E2766AC876220381" modified="2014-04-16" version="1">MDNMDKYNSQWVSFHIRDHIKDGEILVQNTVIEGAEFTDPNNRRKSLTEEEVDEIKISHDGVGEIGASSRRGSEGRLDLFHDNDKICELHWENRGGDYANLVEVLDKSDKYTIQHGGWSAEAGPLGHVFVDVVEKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W6QYJ0</accession>
    <name>W6QYJ0_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Zinc finger, HIT-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PROQFM164_S03g001336</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QYJ0"/>
    <dbReference type="STRING" id="1365484.W6QYJ0"/>
    <dbReference type="OMA" id="CCMCGYW"/>
    <dbReference type="OrthoDB" id="74807at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21437">
        <property type="entry name" value="zf-HIT_ZNHIT1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039723">
        <property type="entry name" value="Vps71/ZNHIT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007529">
        <property type="entry name" value="Znf_HIT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13093">
        <property type="entry name" value="ZINC FINGER HIT DOMAIN CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04438">
        <property type="entry name" value="zf-HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="HIT-type" evidence="5">
        <location>
            <begin position="256"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="149"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDM34612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="301" mass="31911" checksum="AB6B4F5BED8D58B0" modified="2014-04-16" version="1">MFRVELVSDTSTATPGWSYAPTRGFDPTQAMAPTLGRKRGIRDAGKGGDISSRQANAIARHIAELDRENQRDVAIPAPVKQAREAGARGTRAKTTSNVRRILQSQKTFRNHLDDEEAAIASGSGGIGGMQGAGGASVVAQARNSIAAKGGKAAATLRRSATPASTAGAKRPAAAMADTTAGVSAPMQETADAEPDADDKPPRKPKLIKSQYDNDPLLRSYAPPVPPDRLMQRLLAEPPLSYSASRAKPPASGRPGRHFCCMCGYWGKIRCKSCHLRTCSLDCYKVHEDSSIGKELGLALSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>W6QZS7</accession>
    <name>W6QZS7_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DNA-directed RNA polymerase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">RPC11</name>
        <name evidence="14" type="ORF">PROQFM164_S03g001799</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8 12">Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM35072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QZS7"/>
    <dbReference type="STRING" id="1365484.W6QZS7"/>
    <dbReference type="OMA" id="MEFCDEC"/>
    <dbReference type="OrthoDB" id="282152at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006386">
        <property type="term" value="P:termination of RNA polymerase III transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd10509">
        <property type="entry name" value="Zn-ribbon_RPC11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.10:FF:000005">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012164">
        <property type="entry name" value="Rpa12/Rpb9/Rpc10/TFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001529">
        <property type="entry name" value="Zn_ribbon_RPB9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034014">
        <property type="entry name" value="Zn_ribbon_RPC11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001222">
        <property type="entry name" value="Znf_TFIIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239:SF12">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02150">
        <property type="entry name" value="Zn_ribbon_RPB9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01096">
        <property type="entry name" value="Zn_ribbon_TFIIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005586">
        <property type="entry name" value="RNApol_RpoM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00661">
        <property type="entry name" value="RPOL9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00440">
        <property type="entry name" value="ZnF_C2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51133">
        <property type="entry name" value="ZF_TFIIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8 12" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="3 9 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 9" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIS-type" evidence="13">
        <location>
            <begin position="72"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="10">
        <location>
            <begin position="5"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="5"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="8"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR005586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR005586-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR005586-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDM35072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="116" mass="13118" checksum="10974716F5CA2A7F" modified="2014-04-16" version="1">MLVFCPNCSNALTISKAESSTRFPAGVNRFECRVCPYEAPLEKNYFEKKDMKQKEVDDVFGGKEEFANADSVGTQCPAESCNGERAYFFQLQIRSADEPMTTFLKCTSCGARWREN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W6R289</accession>
    <name>W6R289_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S04</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S04g000838</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6R289"/>
    <dbReference type="STRING" id="1365484.W6R289"/>
    <dbReference type="OrthoDB" id="3645574at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM35957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="189" mass="21795" checksum="66E7C80344580940" modified="2014-04-16" version="1">MFTINPEYRDTEAMRWIQATWLSSTSRGMWDKCFRLPGGKKTKTLYRRTFFRDLSRIFLSLARVPLPSIGSFVIDKDGYLQLTNRPLLLEIQDREISEDAVDYEAARTELMEILENEEGLFGEASRKANLSGIMDRSWRSGTFWFSLALASPVSFRSSTSKFSPALVNIVRIRMRPSKRQCHGTGLRIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W6R2Z0</accession>
    <name>W6R2Z0_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Zinc/iron permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PROQFM164_S05g000020</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6R2Z0"/>
    <dbReference type="STRING" id="1365484.W6R2Z0"/>
    <dbReference type="OMA" id="ACDCANT"/>
    <dbReference type="OrthoDB" id="448280at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040:SF60">
        <property type="entry name" value="FAMILY ZINC TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04010)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040">
        <property type="entry name" value="ZINC/IRON TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="136"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="399"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="443"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="204"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="226"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="240"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM36187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="461" mass="50187" checksum="3B916AC0A1496781" modified="2014-04-16" version="1">MQNAQDWQTAKDLPSDLKRALSAISEIPDALLRAELLRRGGASEDTPACGSKQRGKYNTPLHVMALFLILGLSTFACSFPVLARRFPRLPIPRRFLFISRHFGTGVLIATAFVHLLPTAFVSLTDPCLPRFWSQTYRAMPGFVAMISVFAVVIVEMFFAMKGAKHVHGSEYDNLIGEVRRGSIRDGGNADIDYSGLEARQVSDNLNLDSMGHNSKLRTTRASSSSHESDRLHLADSSPDKEDDEDDLDGLDDYMDDDGLISGQAHSAQSQPVHRHRSRVSESHCQQTDTDVPIQNPQRQLLQCLLLEAGILFHSIFIGMALSVATGTSFVVLLIAISFHQTFEGFALGSRIASLIPDLFAPNSMKPWLMSLAYGTTTPLGQAIGLVLHNLYDPGSATGLLMVGITNAISSGLLLFAGLVELLAEDFLSESSYETLKGRRRVEACVSVACGALLMAFVGAFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W6R3X2</accession>
    <name>W6R3X2_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S05g000330</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6R3X2"/>
    <dbReference type="OMA" id="CRARKQS"/>
    <dbReference type="OrthoDB" id="4296339at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM36497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="168" mass="19200" checksum="F6EE55E7828D0067" modified="2014-04-16" version="1">MGISNTLWSRFIELFGRCRARKQSQEGLQEVVYQCSAPHRGTSVKLISAEELDELAKQPSSSDFNVGNLRIRILGQLVDSRSTNVYHMQREIRKTEEIPGTKDLMQELWFEHYWASQTELIKSSIGRDLLQDEASKGVSEPLPEDHAFNYSSFAQLLHTLDSAIMQLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W6R9I0</accession>
    <name>W6R9I0_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Aflatoxin regulatory protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PROQFM164_S14g000021</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792028">
        <property type="protein sequence ID" value="CDM38522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6R9I0"/>
    <dbReference type="STRING" id="1365484.W6R9I0"/>
    <dbReference type="OrthoDB" id="2740448at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045122">
        <property type="term" value="P:aflatoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013700">
        <property type="entry name" value="AflR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08493">
        <property type="entry name" value="AflR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Aflatoxin regulatory protein" evidence="7">
        <location>
            <begin position="28"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="26"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM38522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="96" mass="10601" checksum="581260E7F672B7D1" modified="2014-04-16" version="1">MPPPLHYHCDPKSPLTPHSRKQLLFLRNRRRSGGQSASGPEPARMSGSVLKNNKDAGMSVCRMLQCGCALRPQNPVLLALLCSRLVPSRLQSHMTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W6PQM4</accession>
    <name>W6PQM4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transcription factor, MADS-box</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PROQFM164_S01g000004</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PQM4"/>
    <dbReference type="STRING" id="1365484.W6PQM4"/>
    <dbReference type="OMA" id="FEYCTEC"/>
    <dbReference type="OrthoDB" id="1898716at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1810.10">
        <property type="entry name" value="Transcription factor, MADS-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002100">
        <property type="entry name" value="TF_MADSbox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036879">
        <property type="entry name" value="TF_MADSbox_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00319">
        <property type="entry name" value="SRF-TF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55455">
        <property type="entry name" value="SRF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="MADS-box" evidence="6">
        <location>
            <begin position="34"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM26195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="121" mass="13999" checksum="3448898833CAE1D5" modified="2014-04-16" version="1">MEPSPVVNISLPTNIANSKFKTSHARRGNQKSLRRRETLLKKIFEYCTECDADIHFVLRMKKTGQLYTLTSNAKEWPLSTEQINKESNHPEPIQMKMDELAIKYQGQSPQGEHRPMSLLKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W6PRM2</accession>
    <name>W6PRM2_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Major facilitator superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PROQFM164_S01g000210</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PRM2"/>
    <dbReference type="STRING" id="1365484.W6PRM2"/>
    <dbReference type="OMA" id="FWTPLAF"/>
    <dbReference type="OrthoDB" id="2105912at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17324">
        <property type="entry name" value="MFS_NepI_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42910:SF1">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42910">
        <property type="entry name" value="TRANSPORTER SCO4007-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="129"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="213"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="246"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="326"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="360"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="448"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="4">
        <location>
            <begin position="89"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDM26401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="489" mass="54078" checksum="3B2F2C33D164AD28" modified="2014-04-16" version="1">MTADSTQRVGNHSSSQIEGSAELLPITSAQSNSPAAQGFDEDEKDHDVNVQSTTEESIGKRKYWRRFIDAVSWTPPRCRWNTENPIKFGLPLNILFAFSATFTVANLYYSHPILDILAQFFDVSHERASLIPTCSQAGYATGLILLCPLGDLVRRRHFVLLLTLVTAALWVGVCITKSFEVFLVLSYLSSVTTVTPQVMLPLVGDLVPPARRATALSIVSSGLVLGLLFARLLSGIVAEYSYWRNIYWLSLGLQFLIFALLWLFMPDYPSTNTNISYFKILYSIIGYYWKSPVLVQATLMGFFLSATFTSFWTTLTFLLSGDPYNYPTLTIGLFSLAGLTPMFLGPLFSRYMIDKFVPQFSILVSFSILITGVSVGTYTGTYTVAGPIIQAALQDFGLQMTQVANRVAIYSVAPKARNRINTGYMIGVFCGQLMGTSVGNRLYSQGGWILSGSVNMAFIGVALTICLLRGPAEKGWVGWHGGIRIRRIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W6PSD3</accession>
    <name>W6PSD3_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cell division control protein 16</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cdc16</name>
        <name evidence="3" type="ORF">PROQFM164_S01g000947</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PSD3"/>
    <dbReference type="STRING" id="1365484.W6PSD3"/>
    <dbReference type="OMA" id="MEGVHKG"/>
    <dbReference type="OrthoDB" id="10263206at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031030">
        <property type="term" value="P:negative regulation of septation initiation signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000026">
        <property type="entry name" value="Mitotic check point protein (Bub2)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957:SF263">
        <property type="entry name" value="MITOTIC CHECK POINT PROTEIN BUB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="2">
        <location>
            <begin position="148"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="59"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="80"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM27138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="443" mass="49132" checksum="0631FC92020FB27B" modified="2014-04-16" version="1">MAKPQPPWALGIPGPDAPPSPRTMRTLRKIQSHQVLSTSSALIAQTQASQQTGSHESQPGSTATPGAATRARAHRRARSNSDAASREAAATPPATQRRPPRKTGSGIGIKRSLLESFLRDGPQSSNPNEGLRELKYLVLSSRVDADGDGMSPYRIYLWLVLLDIPPMPTDEYLDLIHRGRSPAYAKIRNDTFRTLATDPLFKRRVTEASLIRLLNAVAWKLHDSRPKPRSRPTSSRRREMELLVNAPPSIAEESPFGGELEKITNSTTSDSAMYVQGMNVLCAPFLYAARSEVEAFALFHYFVTRECPGYVRSAMDGVHKGLRLVDRCLEIVEPKLAAYLFSKGMHAELYAFPSVLTLCACTPPLPEVLHLWDFLFAYGAHLNILCIVAQLIRMRDLILESPSPNKILRSFPPLNAKEIIALTVLLVRKIPENLYAEMISHAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>W6PSW3</accession>
    <name>W6PSW3_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PROQFM164_S01g000774</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Plastid</location>
            <location evidence="1">Chloroplast</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1365484.W6PSW3"/>
    <dbReference type="OMA" id="TFPVEMK"/>
    <dbReference type="OrthoDB" id="5600252at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd17917">
        <property type="entry name" value="DEXHc_RHA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000819">
        <property type="entry name" value="ATP dependent RNA helicase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000500">
        <property type="entry name" value="ATP-dependent RNA helicase DHX29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000002">
        <property type="entry name" value="Putative ATP-dependent RNA helicase DHX36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF145">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX57-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="7 15" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0934">Plastid</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="674"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="920"/>
            <end position="1097"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="246"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="324"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="382"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="41"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="248"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="390"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CDM26965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="1450" mass="163191" checksum="EBE5E13C1D13E328" modified="2014-04-16" version="1">MPPSSKKKKKPASNPARGFATVSMPSKPKPEATSTPSPATEESKATPEIELQPERNAIRIADVAAPQKTSSLQDYTPEELEKHLEEAELQILVDKYAAKCKNDAARQATKLENERRVFRQQSVSLSLLEWLPTDIQDSILELAGTEEHDYLIASGRITSPKQAGSEDDLYNKLWTLRETLLKLNFPENRVEDALKHVLQYFAGNSNSAGRDVVWNLDEAIEWLATHSDKNELPSYTQINTRQLKDTDSVTSWMTESKASGTSTPVSSQNRSKPGNKKADWKAAKVAPPISYDSDSSVDPDIMVPEWLELQTRLYSLDPDLFDRSGKGKKGRVGASNLSDDPETSKVQRKIAKIERDVLFERREAEYIWEQKLDELRKDASFARRPVKKKSSTDAEDQPKPEINEELEPALLAIDGMEDALGDLFQGEAEDSGSILGIPAPQTQTSITLRDFGKSTGLSPRRVLEETCKSRDSTCVIVYQDFSSSSHSNRKALEVRWSKPQEAPFPLAVESITHKSNALATFVSMDALATPNAQQAEGYVSTLALFILFPQNSKEGKAYLRLPAVWRELWTEFATLQKIQQDEVDKTTVKELKRLIQENQGTFEDDVVLSDNFRKRNGVGSKPGTPMKGPTRDNYAGIDDRLKEAWIAKSSTPSYHRMMQGRMNLPIWGFKDEILSTLDDHRAMIICSETGSGKSTQIPSFILEHEMIQGRPCKIYVTEPRRISAISLARRVSEELGESKNDVGTNRSLIGFAVRLESKFTQSTPLIYATTGVVVRMLERPDDFQDITHVVLDEVHERTIDSDFLLIVLRRLMQKRPDLKLILMSATLDAQRFSNYLGGVPVLNIPGRTFPVEMKYLEDAVEMTNYRLSEDAQHTVLDDDMDDPPTDADTTGGLQASLDGYSRQTKETVINIDEYRLDYDLIKRLLLKIATAPEMTHYSKAILIFMPGLAEIRRLNDEILSEPMFQRGWIVHTLHSSIASEDQEKAFNVPPEGTRKIVIATNIAETGITIPDITAVVDAGKEKIMRFDERRQLSRLVESFISRANAKQRRGRAGRVQNGICFHLFTKHRHEKLLSEQQTPELLRLSLQDLVLRVKICKLGEVEQTLLEALDPPSSKNIRRAIDSLKEVKALTSNESLTSLGTQLAKLPLDVFLGKMIIHGAFFRCLDATVSIAAILSSKSPFVNTIGSNSQRDGARASFRRGDSDLLTVYNAYCSWRRTRSTPGSNEYSFCRKNFLSAQTLLAIEDIKMQLVVSIADAGLLTLDASQKAALNRARSNSRNRQFFIIPEDFDINSNNDTVINSVIAWSFYPKLLTREGKGWRNVGNNQTVTLPAVSVNKRADSSVKWLSYYSIMARARNLNAHDTSAVDDFAIALLCGDAEFKMYSGVVSIDANRIRFAVRDWKSMLALRILNSRLREILSITFRNPHRPLSYKHQQWIDIWQQIFSQAGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W6PT42</accession>
    <name>W6PT42_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 9">Chitin synthase</fullName>
            <ecNumber evidence="2 9">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PROQFM164_S01g001162</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Polymerizes chitin, a structural polymer of the cell wall and septum, by transferring the sugar moiety of UDP-GlcNAc to the non-reducing end of the growing chitin polymer.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-D-glucosamine = [(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16637"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9595"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="EC" id="2.4.1.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cell membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the chitin synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="2 9"/>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PT42"/>
    <dbReference type="STRING" id="1365484.W6PT42"/>
    <dbReference type="OMA" id="TAWYFKI"/>
    <dbReference type="OrthoDB" id="26569at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04190">
        <property type="entry name" value="Chitin_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013616">
        <property type="entry name" value="Chitin_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF39">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01644">
        <property type="entry name" value="Chitin_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08407">
        <property type="entry name" value="Chitin_synth_1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="4 9" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="550"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="610"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="636"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="680"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="721"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="819"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="858"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin synthase N-terminal" evidence="11">
        <location>
            <begin position="125"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="48"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="100"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="100"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="112"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU366040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDM27353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="890" mass="100546" checksum="C51A202F3F3BEE65" modified="2014-04-16" version="1">MNYFDRPYSSHYVRQTNESDGLSDGYSPQNTRVPNEHALSLLHPAHSSALSLSPSTDPISWSEGTRRPYNSSSAEVQSPRPGSMESLDLPDQIRLHNLSHQGSAVSSSKESGRHKGSSIRRYPTRRIKLTQGSVLSINYPVPSPIRNAIQPEYRDAEGELSEEFTQMRYTAATCDPDEFTLRNGYNLRPSMYNRHTELLIAVTYYNEDKVLTARTLHGVMQNVRDIVKLKKTEFWDRGGPAWQKIVVCLVFDGMDPCDKNTLDVLATIGVFQDGVMKQDVDGRETIAHVFEYTTQLSVTPKQELVRPYKDDPMNLPPVQMMFCLKKKNAKKINSHRWLFNAFGRILNPEICILIDAGTKPGPKSLLALWQAFYNDKNIGGACGEIHALLGHRWKKLLNPLVAAQNFEYKISNILDKPLESSFGYVSVLPGAFSAYRYRAIMGRPLEQYFHGDHTLAQKLGKKGIDGMNIFKKNMFLAEDRILCFELVAKAGNQWLLTYVKASKGETDVPERPAEFLSQRRRWLNGSFAASLYSVMHFNRIYKSGHGIIRLLLLHIQLIYNICQLVMTWLSLASYWLTSSVILDIVGTPSATNKFKGWPFGNDATPIVNNLLKIGYLTFLMLQFILALGNRPKGSKFLYTLSFVYFSVVQLYLLILSFYLVAQAMTPENLNFDFSHGFSALISGFFNSTGGLVLIALVSTYGIYFIASILYADPWHMLTSSWAYFLGMPSSINVLMVYAFCNWHDVSWGTKGSDAPEKLPSAQTKKDDETPFVEELDKPQVDIDEQFASTVKRALTPWQEPTENEGVALDDSYKAFRTNLVLLWTFSNGLLALCINNLSIDRLCLTSTSTTRTAWYFKIILLATSGLSIFRFFGALYFLVKTGVLCCISRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W6PTP3</accession>
    <name>W6PTP3_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g000955</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PTP3"/>
    <dbReference type="STRING" id="1365484.W6PTP3"/>
    <dbReference type="OMA" id="WKDECAG"/>
    <dbReference type="OrthoDB" id="5429993at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="48"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM27146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="532" mass="58334" checksum="F4188E487440AE10" modified="2014-04-16" version="1">MPIPTRSFSLRDPRKQTSSIARPATKTPTPLPGTASPSKDSARETNSKNRSPSNPSPVEGVALKDNGPTARGKTLLPQRSNLALDNGRGTGHGRIQPPSIKPKPRGHPSPIRQPEISPARKQTQADSTAIKIGVAPSRRQSIMRPGALKVPLAKITVASSKSSAQSFAPPSPRKAPGRPLPVQPHTIRSPSSPKKTETLPPPRPTRSLSLRQPVSASKGPPTAAKTHVRHKSQLAQNTKQAETTPVIGQRARAHSTYQRPSSPKKSSKPPTPTPGAEPQSGNVLIPSSWPDIAALQTELLQLSLFHSNSLQSQAEWKSDSESRLRKKYDSVASQYRLVLANETQQQCHLNAQALRLWLSNCREHRGPHDFSEQIQILSRVLQDVSDMIAGSRGAQYSRAVKTFEDWLNQAELIRHKRGSGCLDVGAFIDPLGRSWKESLHALNVKLELCVRQLQVLDIPGLGELERLEQSALARVARNLVELIQLMMQEIRAMQTLETEVVRSERDYVGLLATQLVCSMKETRAPQVGAWRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W6PUM2</accession>
    <name>W6PUM2_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g001729</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PUM2"/>
    <dbReference type="OrthoDB" id="5304367at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM27918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="56" mass="6201" checksum="80AA24756490B5C9" modified="2014-04-16" version="1">MAILLLTYCSSSIRSARRDAQTHVPGPHQPPPRKDESWVEQALEESRAQNGGKGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>W6PV64</accession>
    <name>W6PV64_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PROQFM164_S01g001944</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PV64"/>
    <dbReference type="STRING" id="1365484.W6PV64"/>
    <dbReference type="OMA" id="NFTHRVH"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019236">
        <property type="term" value="P:response to pheromone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01093">
        <property type="entry name" value="CRIB_PAK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06614">
        <property type="entry name" value="STKc_PAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000139">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000705">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.810.10:FF:000005">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.810.10">
        <property type="entry name" value="CRIB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000095">
        <property type="entry name" value="CRIB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036936">
        <property type="entry name" value="CRIB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051931">
        <property type="entry name" value="PAK3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033923">
        <property type="entry name" value="PAK_BD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE SAMKA-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832:SF22">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE SAMKA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00786">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15413">
        <property type="entry name" value="PH_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00285">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50108">
        <property type="entry name" value="CRIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0589">Pheromone response</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PH" evidence="12">
        <location>
            <begin position="84"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="CRIB" evidence="14">
        <location>
            <begin position="200"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="547"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="270"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="36"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="305"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="329"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CDM28133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="836" mass="91888" checksum="DDB8D297A3EFF06E" modified="2014-04-16" version="1">MTSYGNNMYAPEQFMNPGPAPRPPTDRPPKLTLPTNSTTSSFGQMSSDSPITPGLSSANLSLFPNTSSPSLAVTRSNTTQNGISIIKEGTVRCKEDKFLATWNTRYLILREFKLEFLKSDSGKVVITFPLSTVTAVARSEDSKMAFEVTRLANPKDANSKTALLARDLPTKTITCEVKSDDEIYEWIDKIYERCPGMGGVSNPTNFSHRVHVGFDPNTGAFVGLPPEWEKLLTSSAITKEDYKKNPQAVIEVLEFYSDIKMREQNPQYYAGINSSPNGQPKAYGSSVGSSIAPPRPAPPGPMQRLDSSQSKQSEGSMRSASSSVGQADRAADHQQQVDRMKEIADQERRRVEEERRNKEEQDAYNASIPKGRPTMAQQELGGYGGDDSSQNSRYQPSRPAPQAPGSAARQQDRQLTAQRPAPAPPSQSPYGQSAAPGAPRTDDQQGSPSSRSDPRAPGSANRPQQNGSKAGPPPTRLPAPVQAVKPLNIANKQNGTKNVPDGVRLAEAALTKKAEPRKEVRMSGMSENEVMERLRSVVSKDNPNESYSKQRKIGQGASGSVYVARVKETAPTGVAHELYRTYGPRCQVAIKQMDLRSQPRKELIVNEIIVMKDSQHPNIVNFLDSFLQESSNELWVVMEFMEGGALTDVIDNNPVITEGQIATICFETCKGLAHLHNQSIIHRDIKSDNVLLDRVGHVKITDFGFCAKLTEHKSKRATMVGTPYWMAPEVVKQKEYGPKVDCWSLGIMAIEMIESEPPYLNEEPLKALYLIATNGTPRLKKPEKLSKELKAFLSVCLCVNVHSRASADELLAHEFLQTGCSLASLAELLRWKKATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W6PVY3</accession>
    <name>W6PVY3_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Small GTPase superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S01g002194</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PVY3"/>
    <dbReference type="STRING" id="1365484.W6PVY3"/>
    <dbReference type="OMA" id="GERIPVM"/>
    <dbReference type="OrthoDB" id="25896at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050227">
        <property type="entry name" value="Rab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47977">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM28383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="205" mass="22857" checksum="53F55A67298B9574" modified="2014-04-16" version="1">MAEADPHTDGNKPVSLLLLGDEGCGKSTFLARLKSGRSSPSGTSNNDSNTIELLRDSDQPFIYDIRFAKKTFTLELNDTSNPNQHWTSLRPDLVVLAYDISNRDTLTGLKEWRNDITRYFQYGHGERLPVMMLGLKRDLRREGEGIIYPQEAYRIAQELVCDRYAECSAVTGELLAETFEDLARLAAMTTTAKGGQTEGTSCVIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W6PW88</accession>
    <name>W6PW88_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g000023</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PW88"/>
    <dbReference type="STRING" id="1365484.W6PW88"/>
    <dbReference type="OrthoDB" id="3919880at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046496">
        <property type="entry name" value="DUF6589"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20231">
        <property type="entry name" value="DUF6589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6589" evidence="1">
        <location>
            <begin position="6"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM26214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="183" mass="21345" checksum="B005059A6C21B10D" modified="2014-04-16" version="1">MPGNRDDEILHQTQRYWIAEAIRYTHRDAIHDVFTDELVEWPQFPCVERLLPQKTMHYSLGPILENEGTIDGTYNVIDKVFTDQLGYDPSSDFNDILHLVFGDQKTISLIRAVQKERRGSTLSYDKHDWILPIPGLFHWRTNYMDMIHDLYSGLESASIGCTLHHNKNFMAASRAIKVHFITR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W6PWD7</accession>
    <name>W6PWD7_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Riboflavin biosynthesis protein RibD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g002046</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PWD7"/>
    <dbReference type="STRING" id="1365484.W6PWD7"/>
    <dbReference type="OrthoDB" id="252265at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18785">
        <property type="entry name" value="Inv-AAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM28235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="129" mass="14781" checksum="71A14FBA1E275640" modified="2014-04-16" version="1">MLSTGHSLEYPRDYNEDLGTTHAEQCCFIKIADEYNLPEERIHEVLPANTVLYTTMEPCNERLSGNMTCATRILRLRSAIKTVYVKIKEPGTFIPHNDGQQRLEANGVKVVFPVEHWHDRIIKVSMTGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W6PWI5</accession>
    <name>W6PWI5_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Efficient mitochondria targeting-associated protein 19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PROQFM164_S01g001977</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM97/sigma-2 receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PWI5"/>
    <dbReference type="STRING" id="1365484.W6PWI5"/>
    <dbReference type="OMA" id="EFKDPMV"/>
    <dbReference type="OrthoDB" id="433124at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033118">
        <property type="entry name" value="EXPERA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051987">
        <property type="entry name" value="Sigma-2_receptor-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016964">
        <property type="entry name" value="Sigma2_recept"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31204">
        <property type="entry name" value="SIGMA INTRACELLULAR RECEPTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31204:SF1">
        <property type="entry name" value="SIGMA INTRACELLULAR RECEPTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05241">
        <property type="entry name" value="EBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF031032">
        <property type="entry name" value="TMP_97_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51751">
        <property type="entry name" value="EXPERA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="15"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="100"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="EXPERA" evidence="9">
        <location>
            <begin position="13"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR031032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDM28166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="167" mass="19729" checksum="C32C8663BC04B022" modified="2014-04-16" version="1">MTQHIMSICTRKRDLSYLLFFVTHVPIILLIDTVPLLPAFLQTNLSHHLRQFYITTYRDKFFEDPPTWFTVFIWMELLYHLPLSIWAVRGLLKDHPLVPVHLLVFGIQAFITTLTSLVVVWSWTDRSVAEKQQLTMLYAPYMALGGFMALDMVFRLRDKLMPKTKRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W6PWJ4</accession>
    <name>W6PWJ4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g002081</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PWJ4"/>
    <dbReference type="OrthoDB" id="4496885at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM28270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="77" mass="8941" checksum="658C0688A91CEC0E" modified="2014-04-16" version="1">MPEREEDRESISEPLPEDLQKIVDKEESDRQIRADYENSFTSTSPKHSLKELVTERLDENPDVPHNSSEKTQEKSQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W6PWJ8</accession>
    <name>W6PWJ8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S01g001987</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PWJ8"/>
    <dbReference type="STRING" id="1365484.W6PWJ8"/>
    <dbReference type="OMA" id="CRVVMGY"/>
    <dbReference type="OrthoDB" id="418131at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057965">
        <property type="entry name" value="STEEP1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25809">
        <property type="entry name" value="STEEP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STEEP1" evidence="2">
        <location>
            <begin position="6"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM28176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="191" mass="21633" checksum="C6CDFF5C7E862CEB" modified="2014-04-16" version="1">MTDHRLPIQTQHCRFCNHLLLATTRNISTLPRRGGEGKDKALILPLERKSSTDADADADIEADLEEEARTTETEPSSRKTRARHVSNHTTLLLATTIPDRRATIIRREDGIEKRILLRCGRCKVVVGYYLDRLHWASTGDRERERGGARDGEEEGEEERPPAVYLLPGAVVETEKLGGEGVGEREWREWVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W6PXE3</accession>
    <name>W6PXE3_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S01g002431</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asaB hydroxylase/desaturase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PXE3"/>
    <dbReference type="STRING" id="1365484.W6PXE3"/>
    <dbReference type="OrthoDB" id="412788at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044053">
        <property type="entry name" value="AsaB-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041278">
        <property type="entry name" value="CmcJ_NvfI_EfuI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34598">
        <property type="entry name" value="BLL6449 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34598:SF1">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_3G13140)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM28620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="297" mass="33161" checksum="47101D1F797EF447" modified="2014-04-16" version="1">MTTTQTPPVSAQNQGALPPPPRGDITTPLLFSRQFPPDETPYMYIKCPPPEGVPYTNIRGEPSMVTVQDLRGKESSVNLDYDSIHIVQGVPISKTNFDNEEDIRKNYYPLVEQQILANVPGATKVHIFRHGIRHTKNFPVPYNPPALIAHLDHTGDAVVDRVRYHLDEEEAEKLLLGRYRVIHFWQPLNGTVYTCPLAIASSATVKDEDIVTMVSHLKDFSEDFGAPIYRDHQKWYYLSGVGADEAIMLQIFDSYGSKPGSGVKGGRAVHVAFKDPRTPPNAPDRWSIETSALVFGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W6PXR8</accession>
    <name>W6PXR8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g002397</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PXR8"/>
    <dbReference type="OMA" id="HRYIKHR"/>
    <dbReference type="OrthoDB" id="4362480at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="68"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM28586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="112" mass="12161" checksum="EA914E5DF5D42D3D" modified="2014-04-16" version="1">MRQAHIISTSGFKEKNQDVWLQSTAMEKGNILSPGSHPSACDILQPLSRTSLLPSSGALAARAREQQSGSAASSMASSPDCEVQKHIESTQQMCDEDAGGVRTWKRLVVEYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W6PY35</accession>
    <name>W6PY35_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Alpha-1,4 glucan phosphorylase</fullName>
            <ecNumber evidence="10">2.4.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">GPH1</name>
        <name evidence="11" type="ORF">PROQFM164_S01g002482</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>[(1-&gt;4)-alpha-D-glucosyl](n) + phosphate = [(1-&gt;4)-alpha-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:41732"/>
            <dbReference type="Rhea" id="RHEA-COMP:9584"/>
            <dbReference type="Rhea" id="RHEA-COMP:9586"/>
            <dbReference type="ChEBI" id="CHEBI:15444"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="2.4.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 10">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycogen phosphorylase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.1" evidence="10"/>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PY35"/>
    <dbReference type="STRING" id="1365484.W6PY35"/>
    <dbReference type="OMA" id="WLKQANP"/>
    <dbReference type="OrthoDB" id="9215500at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008184">
        <property type="term" value="F:glycogen phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005980">
        <property type="term" value="P:glycogen catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04300">
        <property type="entry name" value="GT35_Glycogen_Phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000002">
        <property type="entry name" value="Alpha-1,4 glucan phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000003">
        <property type="entry name" value="Alpha-1,4 glucan phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011833">
        <property type="entry name" value="Glycg_phsphrylas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000811">
        <property type="entry name" value="Glyco_trans_35"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02093">
        <property type="entry name" value="P_ylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11468">
        <property type="entry name" value="GLYCOGEN PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11468:SF3">
        <property type="entry name" value="GLYCOGEN PHOSPHORYLASE, LIVER FORM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00343">
        <property type="entry name" value="Phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000460">
        <property type="entry name" value="Pprylas_GlgP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="8 10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 9 10" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0808">Transferase</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="9">
        <location>
            <position position="592"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000460-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDM28671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="743" mass="84620" checksum="BF3D6BF93F81B995" modified="2014-04-16" version="1">MGRTLDNAMLNVGLKDVAREGLSDLGFRVEDVIDQEHDAALGNGGLGRLAACFMDSMATLNYPAWGYGLRYRYGIFKQEIVDGYQVEVPDYWLDHNPWEFPRHEITVDIQFYGNVKKYQDENGKIVHSWEDGEVVEAVAYDVPIPGYGTKTTNNLRLWSSKASSGEFDFQKFNAGEYESAVADQQRAETISAVLYPNDNLEQGKELRLKQQYFWCAASLFDIIRRFKKTKRAWGEFPDQVAIQLNDTHPSLAIVELQRILIDKEGLEWDEAWGIVTKTFGYTNHTVLPEALEKWSVPLMQNLLPRHLQIIYDINMFFLQSVEKRFPKDRDLLSRVSIIEESHPKMVRMAYLAIIGSHKVNGVAELHSKLLKSTLFKDFVTVCGPDRFTNVTNGITPRRWLHQANPRLSALIAEKLGSYDFLTDLTKLDKLEAFIKDKPFRNEWAVIKRENKLRLAKHIKATTGFDVNPDALFDVQVKRIHEYKRQQLNIFGVIHRYLTIKAMSAEEKKKVVPRVSVFGGKAAPGYWMAKTIIHLINKVADVVNNDPEVGDLLKVVFIADYNVSKAEIICPASDISEHISTAGTEGSGTSNMKFVLNGGLIIGTCDGANIEITREIGEENIFLFGNLAEDVEDLRHRHFYGDFKLDPNLERVFETIRDDVFGNSSDFSALISSIDEHGDYYLVSDDFNSYITTHAMIDKAFLNKDEWLTKSILSVARMGFFSMDRVTNEYADGIWNIEPLVVKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W6PYB3</accession>
    <name>W6PYB3_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g003055</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PYB3"/>
    <dbReference type="STRING" id="1365484.W6PYB3"/>
    <dbReference type="OMA" id="CTTECAC"/>
    <dbReference type="OrthoDB" id="4360670at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="48"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM29243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="201" mass="23469" checksum="AC5E1B16DC38624F" modified="2014-04-16" version="1">MVFRTETWRIERKRIGWTEYKFLYRKGYKKARCGLDLFVQLIIADYHVRELAQQKEALQEKLEKLDKTQEVLQKEYWYQECELHKWQSSIPGGPMKLAYESLRKNPKWYMQNELIKDCAGRGGCCGRECGCCEKRESTPEKSMGAGHCTTGCACCSSFRGCELTAQEKKNIRDALRAALKYSNSAYLLSMSRAYIIRDRKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W6PYH5</accession>
    <name>W6PYH5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S01g003130</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PYH5"/>
    <dbReference type="STRING" id="1365484.W6PYH5"/>
    <dbReference type="OMA" id="YFPVQMK"/>
    <dbReference type="OrthoDB" id="5599902at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058345">
        <property type="entry name" value="DUF8032"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22949:SF0">
        <property type="entry name" value="RE27538P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22949">
        <property type="entry name" value="WHITE COLLAR 2 PROTEIN WC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26087">
        <property type="entry name" value="DUF8032"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF8032" evidence="2">
        <location>
            <begin position="283"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="394"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="28"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="127"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="237"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="396"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM29318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="691" mass="76590" checksum="03EC60B607EB57D2" modified="2014-04-16" version="1">MTGMVQPDLGPPATKYKEDSIDDPLRHGNSGRSGSQQPQSRSNLAQPQKQGPASPVQPSRSLPPTTYPPPPHQLGNEVLHHNHYGPPPQSRPTTPPILPIHRPRRPPDLMASTAQMQRPYPSIYHTPQSSSPASVASQSHEQHGRNMYSSPQMPPQMFGYPPYSPMNPVQPPYGAHHSPQQHPTTQPLMMPPQKAPSQGPPHQSPHLPTSGMSSSPIMKLDTSHPSSSKQSMLNPPHTATSSHHMSASNPHATPSLGGSTSSAAPGPIPATTPLVVRQDSNGVQWIAFEYSRDRVKTEYTIRCDVESVIVDTLTQEFKTENCVYPRACCSKDQYRGNRLVYETECNAVGWALAELNPALRGKRGLIQRAVDSWRNSNQDPRLRSRRVRRMAKINRRQSVPAQSHMPQQGPVGPSGPPGPGMNAMPAPVPRPNLGPMSMGPPQMHHHHQPDGNPNEEVSGTEYPGHRSMDTRLPQPSIPDLRPVHIFHDTPTTLTPSGSSSGPSMPPLLRDNNLTSLSRHTIATAARIGSTNHDIDEQGPTNEDLFSHLPDGKRRKFILVDDPQRGCRVRVKVVLDKVNMDEIPDSYRESNAVYPRTYFPIQMRDENRVIPAKRFFRDDAEQADDPESSTVGRTTVPAPSLDADAEIDVPKISRRKHHKELMLNDLGYRMSWSQSRVFAGRILFLQRSFFVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W6PZG5</accession>
    <name>W6PZG5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein kinase, catalytic domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g003460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PZG5"/>
    <dbReference type="STRING" id="1365484.W6PZG5"/>
    <dbReference type="OMA" id="GCKERPE"/>
    <dbReference type="OrthoDB" id="4185642at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM29648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="138" mass="16227" checksum="B4BFF5FB9F457095" modified="2014-04-16" version="1">MKVHHGRGPRRYYEQEGRGLDIHVLEATTYTRLKEQGLCDRGIVPDFLGFMRKFDPSLCQPHLRKFLDDEYPPSAIFLEYITSLGMINLRNYTPQRVNNLLKGIRQIHKVLVRHRDSKPRNMMIVKDSSDAESRLARF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>W6PZM5</accession>
    <name>W6PZM5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S01g003525</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PZM5"/>
    <dbReference type="OrthoDB" id="3868412at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM29713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="54" mass="6205" checksum="44721432B220F091" modified="2014-04-16" version="1">MNPLILLGRAFLQLKRERVWKIGLPVRSAVLKPHTSNQSIIQYAFPLEAAMKPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W6PZN1</accession>
    <name>W6PZN1_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g003536</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PZN1"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="62"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM29723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="77" mass="7887" checksum="5F77A9AFD93868A0" modified="2014-04-16" version="1">MANNRGPGPSRNNGNQGPSHTGNTPTPAASPPLPGFDIAQFTELIKKAIQTSLRNNANTLRGPQGNQGPQGEQGSPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W6PZX8</accession>
    <name>W6PZX8_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">tRNA(m1A58)-methyltransferase subunit TRM6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">trm6</name>
        <name evidence="8" type="ORF">PROQFM164_S01g003631</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRM6/GCD10 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PZX8"/>
    <dbReference type="STRING" id="1365484.W6PZX8"/>
    <dbReference type="OMA" id="EGYIFHA"/>
    <dbReference type="OrthoDB" id="10254665at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031515">
        <property type="term" value="C:tRNA (m1A) methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017423">
        <property type="entry name" value="TRM6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12945">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12945:SF0">
        <property type="entry name" value="TRNA (ADENINE(58)-N(1))-METHYLTRANSFERASE NON-CATALYTIC SUBUNIT TRM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04189">
        <property type="entry name" value="Gcd10p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="251"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="531"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="253"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM29818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="552" mass="61377" checksum="37B74CBF7BC742B5" modified="2014-04-16" version="1">MHSYIRPGQFVAIRLQSDQLRLIQIIPDTVVNLGRFGNFTANQIIGRPFYFTFEILDACDDAGHQLRVVSATELHAETLLADGEGDGEGDDVDTGENGIPMRTNRQINDENSSQKLTLQEIEELKREAGGAGKDIVAKLLESHSAIDQKTAFSLAKYTLRKRKKYLKRFTVLPLDVGLLANYLIEERDAQKAMELRDEHIGLIGCWGNVHHSGNVEVGEGMKPHGRYAIVDETGGLVVAAMAERMGILYPHDADEDPTEEQDPPAHNAAESQHTDEPPKPRRIRPQPMSATTNTITVIHPYSQPNLSLLKFFGYDTNNPDESHPLHTHLKSISWMQLADPNSDPLYANEPPIIPAEELAELKQSKRTAYYHKRNRWGRVKAVVDEGRAGNFDGLIVSTLLEPASVLKTMVPLLAGSAPVVVYSPTVESLVELTDMYSTARRTAFINKKRELESQSPEGEAVDLSSLHEEFVVDPTILLPPTLQTSRVRPWQVLPGRTHPLMTGRGGAEGYLFHGVRVFPTTQNIQAAGNVRKRRKVETTSTPISDRDVEMTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q0C4</accession>
    <name>W6Q0C4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Basic-leucine zipper domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S01g003548</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q0C4"/>
    <dbReference type="STRING" id="1365484.W6Q0C4"/>
    <dbReference type="OMA" id="YREMIGT"/>
    <dbReference type="OrthoDB" id="4496773at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052635">
        <property type="entry name" value="Sec_Metab_Biosynth_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39607:SF3">
        <property type="entry name" value="BZIP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39607">
        <property type="entry name" value="XANTHOCILLIN BIOSYNTHESIS CLUSTER TRANSCRIPTION FACTOR XANC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="2">
        <location>
            <begin position="22"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM29735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="315" mass="34469" checksum="B7416008557CDCC7" modified="2014-04-16" version="1">MEDQSMSPKDDILSQTQDPLERRRLQNRLSQRNHRRKIRERIAKLQDRVIANELRAAAALNGWDQVYNPSLFPRSHSSYSETEPVFTSRGVCVSPLIPDQCTSFMPSYPPFSQSWPNDLNTFPQQAYPGDLSQFTGVSEASPIYPITRAPVQLNHITSPPSSGISGETYREMISTPETLVPDSLSTAAPNQPLYYVATEQALPQIIQVINTMSPQYKVIVLVPPESPASASMAVFPSPNYSYGSGHTGPNNGPAAQQSDSQSLGCLCYPQNIHPGPPAYSASKSWMGGGSYLQACPLHKMANSVTPGGAFPVRMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q0Q1</accession>
    <name>W6Q0Q1_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S02g000014</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM29865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q0Q1"/>
    <dbReference type="OrthoDB" id="4232233at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM29865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="70" mass="7750" checksum="F438B10C7F5DDF00" modified="2014-04-16" version="1">MKFDDNTDCETIVLPGIPLGIEFVKGRITCMGEKHLSPEWSTMCLKNNKLAVIMLSNISQGPSLHRTSSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q152</accession>
    <name>W6Q152_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S01g003513</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q152"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM29701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="122" mass="13694" checksum="523C1CFD7BEA07C4" modified="2014-04-16" version="1">MRPKYPVLGHPGTSAYTAVYNSANSKLHEMSNETANASCFHWLSIPHSDSDYRMKSCMHRPIGGCRMLEVNFHGVKHFTEFRLRVRVGGVWVCTQGWGMFSGLAIQVVQSRNLPLKAVQGVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q196</accession>
    <name>W6Q196_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S02g000249</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q196"/>
    <dbReference type="STRING" id="1365484.W6Q196"/>
    <dbReference type="OMA" id="HYSYECT"/>
    <dbReference type="OrthoDB" id="437973at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13917">
        <property type="entry name" value="zf-CCHC_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM30100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="287" mass="32797" checksum="A72BF38072A75C71" modified="2014-04-16" version="1">MNRYRNAPKLGGSNSNRATATTLCQKCLGRDIFDCKASAQERPYVPRPSRTQQLLNPELMPKLSSENPNEFLRKEGVADELLATREEERGRKRDLEDMTDRGVQSPKRARSLSVETISTNRSDSSSPRRNKHGASDRGRRNDSSAPPAKSRKRRFSDSTEGSSGSFYSGPRDRSPSQERTDDRNTRRRRRESSPEERGRHRGAGRHSERRDRRSKSVDKDRVKESRATTQDVPRDRSHRDQAIPSRQSQSGRSKPDPIMEKNQLPRERSLSPFSKRLALTQAMNNGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2024-10-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q200</accession>
    <name>W6Q200_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S02g000459</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q200"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004879551" evidence="1">
        <location>
            <begin position="29"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM30310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="91" mass="9886" checksum="4689BB0316B74127" modified="2014-04-16" version="1">MAFFWWKGNRKACIALGVAIGIAGETDSARPANADGDQFFYARARGVWNSVLLGLDSSRTSLLLADQSFARGPVFCSRTSLLRRVVKCCVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q229</accession>
    <name>W6Q229_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="12">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PROQFM164_S02g000753</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q229"/>
    <dbReference type="STRING" id="1365484.W6Q229"/>
    <dbReference type="OMA" id="PAFNMKY"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000023">
        <property type="term" value="P:maltose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000149">
        <property type="entry name" value="MFS transporter, SP family, general alpha glucoside:H+ symporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF5">
        <property type="entry name" value="ALPHA-GLUCOSIDES PERMEASE MPH2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0462">Maltose metabolism</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="52"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="132"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="156"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="229"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="312"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="350"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="377"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="410"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="441"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="476"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="55"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="531"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00026248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDM30603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="550" mass="61522" checksum="CFDE40E0803922D6" modified="2014-04-16" version="1">MDFKSAAQHVETPDDKSPMDVDPGTLVQEAQIATDKEHRMSLWQALKLYPKAIGWSVLISTAIVMEGYDVVLMGSFYGFPAFNQKYGHTLSDGSQGLSAAWQAGLSNAMNCGQILGLFANGIVSERFGYRKTMLGSLIATMAFIFILFFAPNVETLLVGEILMGIPLGVYQTLSVTYASEVCPVALRAYLTTYVNLCWVMGQLIASGVLKGLESRNDEWAYRIPFAIQWIWPVPIFIGVLMAPESPWWLVRKGRLQEAVKSLTRLTSRGNTDFNAEETVAMIIHTNEVEKQLNEGTSYFDCFRGTNLRRTEISCLIWAAQNLCGAGLMAYSTVFYQRAGLPVSQSFNMSLAQYAIGFFGTLFSWVLMSYLGRRTLYVYSLAVLCVILFVIGFIAIAPSTSATSWATGSMLLVYTFIYDSSAGPVCYSLVSEIPTIRLRIKTVVLARNLYNCFSIFNGVVIPYMLNVDGWNWRGKAGFFWGGLCLASFIWSFFRLPEPKGRTYAEMDALFEQKVSARKFASTKVNLFHEEETKEGIETKEEKEVIETKEDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q2F0</accession>
    <name>W6Q2F0_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein kinase C</fullName>
            <ecNumber evidence="2">2.7.11.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="primary">pkcA</name>
        <name evidence="23" type="ORF">PROQFM164_S02g000868</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.13"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.13" evidence="2"/>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q2F0"/>
    <dbReference type="STRING" id="1365484.W6Q2F0"/>
    <dbReference type="OMA" id="QCTHLVP"/>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004697">
        <property type="term" value="F:diacylglycerol-dependent serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20822">
        <property type="entry name" value="C1_ScPKC1-like_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20823">
        <property type="entry name" value="C1_ScPKC1-like_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08689">
        <property type="entry name" value="C2_fungal_Pkc1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11620">
        <property type="entry name" value="HR1_PKC-like_2_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05570">
        <property type="entry name" value="STKc_PKC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.160:FF:000004">
        <property type="entry name" value="Protein kinase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000101">
        <property type="entry name" value="Protein kinase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000191">
        <property type="entry name" value="Protein kinase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000103">
        <property type="entry name" value="Protein kinase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.20:FF:000014">
        <property type="entry name" value="Protein kinase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.20:FF:000034">
        <property type="entry name" value="Protein kinase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.160">
        <property type="entry name" value="HR1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037778">
        <property type="entry name" value="C2_fungal_PKC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011072">
        <property type="entry name" value="HR1_rho-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036274">
        <property type="entry name" value="HR1_rpt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037312">
        <property type="entry name" value="PKC-like_HR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017892">
        <property type="entry name" value="Pkinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02185">
        <property type="entry name" value="HR1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00433">
        <property type="entry name" value="Pkinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00742">
        <property type="entry name" value="Hr1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46585">
        <property type="entry name" value="HR1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51860">
        <property type="entry name" value="REM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10 23" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="REM-1" evidence="22">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="REM-1" evidence="22">
        <location>
            <begin position="122"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="18">
        <location>
            <begin position="205"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="20">
        <location>
            <begin position="434"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="20">
        <location>
            <begin position="502"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="19">
        <location>
            <begin position="743"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="21">
        <location>
            <begin position="1003"/>
            <end position="1068"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="67"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="329"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="573"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="333"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="17">
        <location>
            <begin position="353"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="574"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="666"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="696"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="713"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="772"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="CDM30718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="1068" mass="119065" checksum="5E7925F3491A9260" modified="2014-04-16" version="1">MDGDELIASVFRKIEREKALITAASNMRQSTDNPLVQQRVDANIRDGRKNIAYLEEKMRELQIRQMNQEGGPAPPPKGHGEGEHYTQGGSGSMPSGAPFADPRPYAPIPKARPNYTKLDLIKYDTPYLGPKIQLMLSQLEFKLSVEMQYKAGIEKMVRLYQDEGDRKSRADAEGRRIESNQKIQLLKQALKRYEDLHVDIESGDAPDDESLSTPNMRKPLTGLLTMRIHAVKDVDHAASSRFSRGPETYIVVKVEDTIKARTKATRNDKWLDESFSMDIDKANEIELTVYDKAGDRPVPIGMLWVRISDIAEEMRRKKIETELNASGWVSADKMGDGGSPRHDQAGSPMGSSHGPGSGGRPGTSGHGAHGHGGESSNAPPTVTIDSWFALEPVGRVQLQMSFAKQLKDRRPFDIGLNRQGAVRQKKEEVHEKQGHKFVTQQFYNIMRCALCGEFLKYAAGMQCADCKYTCHKKCYPKVVTKCISKANYETDPDEEKINHRIPHRFEGFSNISANWCCHCGYLLPFGRKNAKRCSECGLTCHAQCTHLVPDFCGMTMEAANQILETLIRTKNHNKSASVSSGLSNRTLRAGGPPGPPQDNAALSYPQKPMEGPYGSIPRQPSAEAAAQRQQIPPKSPPGPSAAAAAAAAATGLRSPQQAPAEMGRPMLPPQAPPQPQHAHYDPSAYANFPQQPPPQAMAVQPAAYPMAPPPQPIQQQMPQQQVAPPIKDDAAAQAKARIGLDHFNFLAVLGKGNFGKVMLAETKSSRKLYAIKVLKKEFIIENDEVESTKSEKRVFLIANKERHPFLLNLHACFQTETRVYFVMEYISGGDLMLHIQRGQFGLKRAQFYAAEVCLALKYFHENGVIYRDLKLDNILLTMDGHIKIADYGLCKENMWYGGTTSTFCGTPEFMGPEILLDKKYGRAVDWWAFGVLIYQMLLQQSPFRGEDEDEIYDAILADEPLYPIHMPRDSVSILQKLLTREPELRLGSGPTDAQEVMSHAFFRNINWDDIYHKRVPPPFIPTISSPTDTSNFDQEFTSVTPVLTPVQSVLSQAMQEEFRGFSYTADFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q2H2</accession>
    <name>W6Q2H2_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Non-histone chromosomal protein 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PROQFM164_S02g000664</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">DNA-binding protein that induces severe bending of DNA. Required for DNA-binding by the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. Also augments the fidelity of transcription by RNA polymerase III independently of any role in the FACT complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NHP6 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q2H2"/>
    <dbReference type="STRING" id="1365484.W6Q2H2"/>
    <dbReference type="OMA" id="MKNMGGK"/>
    <dbReference type="OrthoDB" id="1919336at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01390">
        <property type="entry name" value="HMG-box_NHP6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.30.10:FF:000016">
        <property type="entry name" value="FACT complex subunit SSRP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050342">
        <property type="entry name" value="HMGB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112">
        <property type="entry name" value="HIGH MOBILITY GROUP PROTEIN DSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112:SF22">
        <property type="entry name" value="MITOCHONDRIAL TRANSCRIPTION FACTOR A, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="8">
        <location>
            <begin position="28"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="6">
        <location>
            <begin position="28"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00043963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00057588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00067275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM30515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="108" mass="12426" checksum="6C0ADE4F1661C51D" modified="2014-04-16" version="1">MPKETTTKTTRKAPEKRVQRRKKDPNAPKRGLSAYMFFANDNRDKVREENPGISFGQVGKQLGDKWKALSETDRKPYDAKAAADKKRYEEEKAAYLAKAEEEEEEESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q3J0</accession>
    <name>W6Q3J0_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">beta-glucosidase</fullName>
            <ecNumber evidence="3">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PROQFM164_S02g000675</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Plays an important role in cellulose degradation. Shows hydrolytic activity against several glycosidic compounds.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyl hydrolase 1 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="3"/>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q3J0"/>
    <dbReference type="STRING" id="1365484.W6Q3J0"/>
    <dbReference type="OMA" id="YQIEGHG"/>
    <dbReference type="OrthoDB" id="65569at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080079">
        <property type="term" value="F:cellobiose glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000011">
        <property type="entry name" value="Cytosolic beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001360">
        <property type="entry name" value="Glyco_hydro_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353">
        <property type="entry name" value="GLYCOSYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353:SF134">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12600)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00232">
        <property type="entry name" value="Glyco_hydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00131">
        <property type="entry name" value="GLHYDRLASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00056775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM30526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="488" mass="55848" checksum="DD623DC94F48022A" modified="2014-04-16" version="1">MDLNSVQDLKDVLRPDFFHGYATAAAQIEGAWNKDGKGVSIWDTFGHTPDKIADGSTADDAVRAYDFYREDVALMKSYGVNAYRFSLSWPRIIPLGGRDDPVNEQGIKFYSDLIDELLRNGITPFITLFHWDIPQALEDRYGGMLNQDAYTPDFMHYARVCFERFGDRVKHWITYNEPGVYTLAGYAAGVHAPGRSSFRERNADGDSSTEPFTVAHTELVSHGHVVRLYREEFQPQQKGSIGITLHGNWSEAWDEEDPRDQEAAERAREFEIAWFADPLYKTGDYPASMQAQLGDRLPRFTEEESKLVFGSSDFYGMNSYTTFFVKHTTSPPDINDHKGNVEICDENKQGVSRGEESDTPWLRAAPGGFRKLLNWIYKRYQMPIYVTENGTTAKGETAPMPEVLNDEFRIKFFEGYVGNALARAVKEDGVDIRSYFAWTFTDNWEWAAGYADRFGSTFIDFESEEKTRYPKQSAYYLDKLFKHLIKDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q3P6</accession>
    <name>W6Q3P6_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="7">EXS, C-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PROQFM164_S02g001105</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q3P6"/>
    <dbReference type="STRING" id="1365484.W6Q3P6"/>
    <dbReference type="OMA" id="FRRWIWI"/>
    <dbReference type="OrthoDB" id="2159384at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004342">
        <property type="entry name" value="EXS_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10783:SF46">
        <property type="entry name" value="PROTEIN ERD1 HOMOLOG 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10783">
        <property type="entry name" value="XENOTROPIC AND POLYTROPIC RETROVIRUS RECEPTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03124">
        <property type="entry name" value="EXS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51380">
        <property type="entry name" value="EXS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="102"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="EXS" evidence="6">
        <location>
            <begin position="188"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM30955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="403" mass="46700" checksum="5EDD6239FCFCEB22" modified="2014-04-16" version="1">MAVDQHAQLDAFGLIFPLPLRIAAILVAGFWGWGLNLQYLAKANIDVPALIKYPARTSSSQRPHHIAVYRLATCFTIPLALWFIVFWVVTRRAPELVERLDWLPQSVYIVLLLILIWPFNRASRSGRIRFLLTLKRISIGGLAESKDGKFGDILLADALTSYARVIGDLYISFCMFFTDGFAATSKPNRACGSEIVVPIILAVPSLIRLRQCLTEYYRARRTVTRRETHKLNQHLANALKYASAFPVIWIASKMRNYNPLELRGYSEVSMMRLLFLVSFINSGYSFWWDVVKDWDMTLFSSESRDSSHPYGLRRHRYFGSDKMYHYVIIADLALRFSWLWRIVPGLGWISETESGLWILMFLEVVRRWMWVFFRTEAEWIRNTHGPGPDDVLLGEYNHKFDAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q4P2</accession>
    <name>W6Q4P2_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type DNA-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PROQFM164_S02g001445</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q4P2"/>
    <dbReference type="STRING" id="1365484.W6Q4P2"/>
    <dbReference type="OMA" id="GINDKDC"/>
    <dbReference type="OrthoDB" id="6486656at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF8">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="29"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="60"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="63"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="96"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM31295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="791" mass="87791" checksum="7C7585A5AB6E2DD1" modified="2014-04-16" version="1">MMTGGFTVDTVEHRSSYVRSPLPTRVRSACERCRRHKSRCDPVRPCSVCIRANVDCRPLPTTRPRRATLPKRLGSKRNPLTERHRSHLSPLTLTEKSPDENDRGRGERIPEQSRLIDAHPRGDDADFPAGGENMPPSLNCGEAESAIGIARRICQLGSHNIDEQTTSAIPGYQASTGGSMANSATGQRIPISSILSRPFPPMELVYSLLEDYFDAVHWFSLAIYEPKFRKSLDSIADGSAYPSQRPFLVLLAVMLGMASWYRSQRNCTDPADNSDDMKKLSADLLGLVESNLVELMDQPSVTSAQTCILLGSHHVYHGRPNLSFSLLGATIKMAQSLGMHRGLLRGDFENIEERKRVWWTIYTWDRFASITYGRPLGINDKDCNLDMPADVFENPNFVSPALGQASPICYSTYQRELNQLYLIASPALKTVFGSRTLRTSKQLNGDTYFALVRHVTENLQKWRSCLPSHLALDLNRDFDPDDTPSLRAYALQSLSLQLTCDNVLIVLHRPLLARQVDHLYTVNEQTPEGSRTDNIMYHPATDPSVAQSNLSPDSGFPNNQTTTPDLWMNAATRTSRVTELPALAQLATDSHLCAFLAINLFNAAIVLAVMALSEPLSDTAQEVKRTITRILRLQDLLGRRSALSKQSTAVLKNVVIMLLRRESAAMLAPVTATSQVMGHQPLQTLADPSLISVEDTLRMPLDATWDSRNPLARDQRLPDLSRADRLNNSLTSVQYALGPGDRSTGIPTGGDSLQPREFVEPGIQAHEVWQLPAEYDWNMPALKVGCIGYGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q4R7</accession>
    <name>W6Q4R7_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="10">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PROQFM164_S02g001794</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q4R7"/>
    <dbReference type="STRING" id="1365484.W6Q4R7"/>
    <dbReference type="OMA" id="FYVSRVL"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000078">
        <property type="entry name" value="MFS maltose transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF77">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="16"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="59"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="95"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="186"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="275"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="314"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="339"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="371"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="410"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="438"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="19"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDM31643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="510" mass="55882" checksum="D338CFA69687DDD6" modified="2014-04-16" version="1">MAGLDLKIDWKSNRRAIAYCMVAAIGALCYGYDTIYYTGIQGMTWFAKDYGERNADGSYSLGTSFLSVSASIIYVGELVGAIGAAPINDFFGRRAVFLSASLCIIVGAIVQVCSFGSDSVFYVSRVLIGLGIGQFTATCLMYIGEVAPSAIRGPALMCFQFMQSISQLVGACVNQGTQSISSSQSYRIPMCLLVVLPGILLLCLPFTPESPVWYMYKGKREKAIKALRRINHSCRDYDPSADIQAIEDQVQMEREMAKDATWVSLIMDPIERRKLFYACGVMFVQQINGIQFWYTYGVVFAQSIGVSDPFTINTIIYVLQIITVGLAVVLGNKINRRTNLLVCSGGMFISLIAVGGLGTTKASDGTFSRGIGIGIVVLAYINIIFYNFSIGTLSYTIASEMSVGRNRNKITACAMGVFFLTLWVMVFTSPYMYYTGHLGPMIGFVYGATTTSLLAYSWFCVGETAGRSNAEIERLFQDKVPARQWATYVIPSDDVTVTKKGAEDEQIEMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q4T3</accession>
    <name>W6Q4T3_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Nucleoside phosphorylase domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PROQFM164_S02g001814</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1365484.W6Q4T3"/>
    <dbReference type="OMA" id="HASALMM"/>
    <dbReference type="OrthoDB" id="195446at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054471">
        <property type="entry name" value="GPIID_WHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22939">
        <property type="entry name" value="WHD_GPIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="25"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="6">
        <location>
            <begin position="384"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="domain" description="GPI inositol-deacylase winged helix" evidence="5">
        <location>
            <begin position="659"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="850"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1047"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1080"/>
            <end position="1112"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1115"/>
            <end position="1147"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1149"/>
            <end position="1181"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1182"/>
            <end position="1214"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1248"/>
            <end position="1280"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1538"/>
            <end position="1570"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1571"/>
            <end position="1603"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1604"/>
            <end position="1636"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1755"/>
            <end position="1787"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1998"/>
            <end position="2024"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF22939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM31663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="2024" mass="223608" checksum="A053B9F9984933C5" modified="2014-04-16" version="1">MSTSLPNERYTVGWVCALPIELSAAKAMLDEEHEGPQTPPKQADDNIYLLGAVGKFNVVITCLPKNEIGSSSAAAVAKDMLFTFPGIRFGLMVGIGAGIPDYELDEVQDVRLGDVVVSSSKENGGVVVYDFGRRLGDGSFQARYPLNQPPRSLRTALTRLETEHMLNESQVASFIEKALTKYPKLRKKGGWVRPNQDSDRLFHAEYPHVGGRTCAECDKDYEIDRQEWERHDTSPVIHYGTIATGSAVVKHAPTRTEIGKTHQAICLEMEAAGLMNAFPCLVIRGISDYADSHKNDTWHNYAAVAASACAKELLQFVTPKEVEAEDTAQKILNSVREDVSSIKESVSVLNTAVVEEHQMAILDWLSPHNFNDVQNDRLAQRIDGTCLWFLETAEMKNWLQSAGQTLFCPGIPGAGKTVMAATIIEHLQSLTKQDPKSVVAYIYCSYQPKSEQAVQNMLQVLLRQVTAKQRSIPDNIKRLHKEHATAGSRPSVKQLLVVLCQCLRQYNRVFIVLDAVDEYYVSDYESHQTLLSELSDIQRDIPINLLMTSRFNNTNVSSKFPGSIQKEIRAHEADILLYLNRKLPIFVVSVAGKVYLEEHIQSMVLQAADGMFLLAQLHTEYLMKMPTIRHLKRSLEALPRGQDGLTPTYVRAMSDIDRQANEIRDLARKALSWLAHSKQALSSVELQHALVTESGQSDLDEELLLDIDILHNLCAGLIVWDRATDVVRLIHYTTHEFLQTEGILKDPESQVALNCLTYMSFEPFSFGRCSNPESYMDRHERYPLYMYCTKHWGDHARNSNSDDAKNVALQFLASIGCFSAACQSMKGPPIKRGKPLDSSNILKYSTCRITAAHVCAYFGLTEWLQILLQNGAEVNAKDSKGDTPLTYAARAGHESTVKLIGPEMSHGVISKDDALEEAAGEGHEADVRYLLSGSAGTEVGQEQKQRALKEAAGKGHVSIMKLLLDQGTNPEYNHIRGGWFREDSPLELAISSGNLEAVRLLLPKDGTISEYANKNMELVFRAVSDANYEMVQLLLNHGADPDLPNTSGRTPFIKAVFKGEKSTARLLLSKDIDVNAQDQTGGNPLIYSVRSGDEELVNALLMKGADPNLRAITWDLETPLDRAVSKGYLKIVQALILKGADPNQPSGSLEDPPLCSAAGNDHEEVVRYLLERGADVNLSNKVNETPLFFAIKARRIQISRLLLSEGAKLDSQNIVGNTALFYAVQCPSNSLAADLITRGSDPNQRNELEETPLFFAARAGSLSSVHLLLNGGAHADPRNKLRETPLLQAATFLCADKESCMEYAAIIELLIANGADPNPTPDLGYPHILFDAVGDGDLVSQWSESDPEKFQQVQESWSKSKRLSKDLFALFCEHISGRNGEGYSKWKNSCSARRSWKDGLVTPLVWSVRAGCTDLSQRLVDLGLDDMDAPSSEPLLYKAADFKHNKVADLIYKSDLRVYVQNIKPGERGTVGKLAFLSAVEMGNLAIISVLQRHSLSYLTSTTRVGDFALLVSSRCGRINLCHHLIDAGFDLHHRDETGKTSLTLASIEGHNDLVELLLQKGCQTEAEDNTGRTPLLWAVQLGNTPAVELLLRAGANPNCLEQNSRTPLLFSTLNGDDFMVELLLKYGANPNFANKAGESALSWAVAQNYEAIANMLLKREARLINENNLNQSSLFWLIRPFLTKRVKSSLTVRRSSYNLKQKAFNKNDIFSVVSTVQVDGKSDFDGDETVGNDMEAMLRLLISHGQNIDLKDENGRTCLARAAFAPNEDYARIFLRHGANPDTQNDLGETPLFLASLRRGGSSPSPAQMKRKTDMIDILACNGANPNLATVYGRTPLMTVAASGALEATQILLKITNVNKHLQDRFGRTAFSEASERSQPHICGLLDPDEVDHDLPVPETVHQMASPKFCDICRVNICSGDEFYHCELCQGGDYDVCNFCLRNGASCLDETHPVSKIIAVPRKAIEPKNSTTEDPSSLMAAHMASLMMASIQSMIGKCSTSSQSGSSESRDASNRLRVRMWRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q4T4</accession>
    <name>W6Q4T4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Mg2+ transporter protein, CorA-like/Zinc transport protein ZntB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PROQFM164_S02g001131</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q4T4"/>
    <dbReference type="STRING" id="1365484.W6Q4T4"/>
    <dbReference type="OMA" id="NYGHIRQ"/>
    <dbReference type="OrthoDB" id="165352at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050897">
        <property type="term" value="F:cobalt ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015087">
        <property type="term" value="F:cobalt ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.20">
        <property type="entry name" value="CorA soluble domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045861">
        <property type="entry name" value="CorA_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46494">
        <property type="entry name" value="CORA FAMILY METAL ION TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46494:SF1">
        <property type="entry name" value="CORA FAMILY METAL ION TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143865">
        <property type="entry name" value="CorA soluble domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="558"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="591"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="211"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="273"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="211"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="287"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDM30981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="638" mass="71988" checksum="8931B5B082964EE3" modified="2014-04-16" version="1">MSIHSVDYAQQGPTRPEVDVEAGRPSVSSQVAPTVGEREGAASPAFTTAARVNSTETTKRRARRNTARSYHPEGFAQDPNWQPGTEPGIDPTKPLPPYTSEWSSNIPADLQRRCQITVVDFSQHEMRQYELDNDTLEQFLQREKEPWVQCRWINVNGLSWDVIKILGNHKRLHRLAIEDVVHDTNRTKVDWYSDHAFVVLTLQKLVKIQEEDSSDSEDEEENPVSPWKSRDRKSSVVSDKSSISLRRPTKWSVIMAALKDIFRFRSSTKQERKDMAKYGSSVRPGLGQNSTQNSHFGNVGATTDTSARSLQRYRGGPNEDRIEFMERHAALSAKGLCVTLEQVSIFLHTDNEVTSFFETSADDIESPIVRRLNTPETILRQSCDASMLLQAILDAVIDLAIPVTMAYQDAIGDLELEVLTDPDIEQSKSLYILTSEIAVLRNHMQPIVAVINALRDHRSEPVGTPGFGVLRNPLSPGATPAEFLDPRPHIGTVPPNLKSVGGTGVTISSMCHTYLGDALDHCITIVEGYDQMRRNADNMIDLIFNTIGAYQNESMKQLTLVTCLYLPMTFLTGYFGMNFTHFAGIEHSEGYFWKIAVPFVLVTIFYLMRDKIQRYAVMLAQRRLIVSSRKQRRERTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q5L9</accession>
    <name>W6Q5L9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S02g002134</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q5L9"/>
    <dbReference type="OMA" id="ADNFLAH"/>
    <dbReference type="OrthoDB" id="4316405at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM31983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="311" mass="34689" checksum="867E642BA7B84F3D" modified="2014-04-16" version="1">MFMWEAYQIFVQIQTAERQKLIFPFRDRRGPAGTSNRHLDSNGRETDKPLNYVEFMLRTLSKPSNLEPPPAITEPSSQGDLQRAQKELADNRVYNFKGTVSLSTISPKLAELEEKASTFISGRGGGSGGGGSGSKGDSESDADKHIRFIRTVSQKVAAVKDDRHLITIGDVSDRLGRAEDISRRIVALRKGQTNNWLVRELSSDQGWNLQEADPNKKGEYRSTVVMAEADTDVPGMPRYQAVDFPRTFAANTEKIKGKGLTTWDKFMAWGEELGNRNAITGGPANTDNNVLHWEEIKPWESFWDKCAVPAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q5N3</accession>
    <name>W6Q5N3_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S02g002149</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q5N3"/>
    <dbReference type="STRING" id="1365484.W6Q5N3"/>
    <dbReference type="OMA" id="RRAFYNF"/>
    <dbReference type="OrthoDB" id="2122015at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007008">
        <property type="term" value="P:outer mitochondrial membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035195">
        <property type="entry name" value="Emr1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17237">
        <property type="entry name" value="Emr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM31998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="54" mass="6236" checksum="40733AEB4D7E0651" modified="2014-04-16" version="1">MANLPNLRRLFVEARTEAEENEYSRKAFYNLVLFISSVAIFSLTAQRMSRPKVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q7J2</accession>
    <name>W6Q7J2_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="11">JAB1/Mov34/MPN/PAD-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PROQFM164_S02g002117</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM164</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M67C family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q7J2"/>
    <dbReference type="STRING" id="1365484.W6Q7J2"/>
    <dbReference type="MEROPS" id="M67.A14"/>
    <dbReference type="OMA" id="SWGVFRL"/>
    <dbReference type="OrthoDB" id="3640at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061578">
        <property type="term" value="F:K63-linked deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140492">
        <property type="term" value="F:metal-dependent deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070536">
        <property type="term" value="P:protein K63-linked deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08066">
        <property type="entry name" value="MPN_AMSH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000033">
        <property type="entry name" value="AMSH-like protease sst2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.80:FF:000024">
        <property type="entry name" value="Endosome-associated ubiquitin isopeptidase (AmsH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.80">
        <property type="entry name" value="Phosphotransferase system, lactose/cellobiose-type IIA subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044098">
        <property type="entry name" value="STAMBP/STALP-like_MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015063">
        <property type="entry name" value="USP8_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12947">
        <property type="entry name" value="AMSH-LIKE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12947:SF13">
        <property type="entry name" value="FI19924P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08969">
        <property type="entry name" value="USP8_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102712">
        <property type="entry name" value="JAB1/MPN domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140856">
        <property type="entry name" value="USP8 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MPN" evidence="10">
        <location>
            <begin position="350"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="120"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="206"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="301"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="206"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="317"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDM31966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="529" mass="59115" checksum="46E72BBA9FBDC6FB" modified="2014-04-16" version="1">MASNAIGGTAPQSVEHITRIAQNYEYNSSVPLRYWLRTAATLLREAHIYEREGHDEQAYLILFRHAQLILVHLSKHPDVKKNEEDRKALVAAEKEVEKNLSKLEILRPRINKRYERYTQLMRERESRQQPSLAKTIPEPREQVPDPALAGVAEPLEAGENRDLAVQLAQSELNRRATIRNSKGLSGPSAEEIETRRAAGIWREWDHSMKSDSRTGDRDHTNQPYSQTPEESEIPSSAASAYKYPTVPRQKPLEPTVSPGQIAILDKNAERFAPPILPPKEHLEPSRASFIDDSTTAVVPSRPAKVLPGPVLPEKIQPSKQTTATRSDLDPSSYTFKPSAYLENGTPLRSVFLPANLRSRFLSMAAFNTRANLETCGILCGTLVSNALFISKLVIPEQTSTSDTCETVNESALFDYCDSEDLMTLGWIHTHPSQTCFMSSRDLHTHCGYQVMLPESIAIVCAPSKNPDWGVFRLTDPPGLKTVLNCNQTGLFHPHAEENIYTGALRPGHVFEVSGLEFETVDLRPDALKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2024-10-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q8A7</accession>
    <name>W6Q8A7_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S02g002766</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q8A7"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM32615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="66" mass="7949" checksum="CDA5F6081D58C986" modified="2014-04-16" version="1">MCRARGRYCRQDPAKCCAPGVLRWGNESAKDWFPWNTQREHFPPWQPRRGCRQCPELSLHFMRTNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q8L9</accession>
    <name>W6Q8L9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S02g003184</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM33033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q8L9"/>
    <dbReference type="OrthoDB" id="10570604at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM33033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="77" mass="8361" checksum="8ED0DB5DD6D53C52" modified="2014-04-16" version="1">MLALPHSPPRSKSLNSSRQLSEEWEPGATGPENIPDVIGLQDANGKTKLKVVGELKIPWVDEDPLVSTAKQTLLPHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q8T9</accession>
    <name>W6Q8T9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Semialdehyde dehydrogenase, NAD-binding</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S02g003239</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM33088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q8T9"/>
    <dbReference type="STRING" id="1365484.W6Q8T9"/>
    <dbReference type="OMA" id="WGERAYY"/>
    <dbReference type="OrthoDB" id="2130169at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051783">
        <property type="entry name" value="NAD(P)-dependent_oxidoreduct"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079:SF6">
        <property type="entry name" value="NAD(P)-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079">
        <property type="entry name" value="PROTEIN YEEZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="1">
        <location>
            <begin position="5"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM33088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="344" mass="37463" checksum="AF5E49BD446A1734" modified="2014-04-16" version="1">MTKLFITGVTGYIGGDSLATLVANHPEFSYSALVRTTEKAEQVKAQYPFIRIVIGDLDDSALLERESAAADIVLHTADASDHVGAAKAIIAGLVAGHSKENPGYLLHTGGTGILSWEDSDKKEYGNRSEHVYDDWDGVDELLNLPDHAFHRNVDQLVLQAAAQHADVLKTALVCPPTIYGKGRGPVNQRSRQVYVLANVTLRLKKGPIIGAGQSLWNNVHVNDLSDVYALLVDAAIAGRTDDGLWGPKAYYLTENGEHCWGELAKATAEAATKLGYLPEAKTEVLDPVIAKQYGGFESLSWGMNSRGRSQRARKILGWNPSRPSLVDELPEIVRGEWERLQNAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q8V5</accession>
    <name>W6Q8V5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S02g000804</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q8V5"/>
    <dbReference type="OMA" id="FNHEIPL"/>
    <dbReference type="OrthoDB" id="4366786at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM30654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="122" mass="13564" checksum="484BA77D71C75EE3" modified="2014-04-16" version="1">MQTAGQVLASPLPLLRQARGTSHPSVSTEWLHQRFIHQWTTFDQEIRSALASLDLNFQIAHIDSPSGEVYLVGNEIGLSGRFVNNVCEPVAKILVRASQPAMVMGDIQALKLQHRTLSQMYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q8Z4</accession>
    <name>W6Q8Z4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PROQFM164_S02g003001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the anthrone oxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q8Z4"/>
    <dbReference type="OrthoDB" id="5954308at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013901">
        <property type="entry name" value="Anthrone_oxy"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35042">
        <property type="entry name" value="ANTHRONE OXYGENASE ENCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35042:SF1">
        <property type="entry name" value="DUF1772-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08592">
        <property type="entry name" value="Anthrone_oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM32850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="119" mass="12845" checksum="590AE75923BD582C" modified="2014-04-16" version="1">MDAHNLAQIAAISSSFWLSGPPFAILGAGGFVWLALESGCWLYWRAAILDVGIVPYTFAFVIQTNSSIFEIANVKDSSEKPASEENRLAPLLNRWACLNTVRSLFPLAGGILGLVAALY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2024-10-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q932</accession>
    <name>W6Q932_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S02g003330</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM33178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="71" mass="8533" checksum="ABACC4DC6D76CB4E" modified="2014-04-16" version="1">MSISRIRQKGWNPNEPDLDPKYVFRERIGDNIMSQVFQFKRMRLLKQYTKIAWNVSRIARDGIDRTALYSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q935</accession>
    <name>W6Q935_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S02g003335</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q935"/>
    <dbReference type="OrthoDB" id="76567at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM33183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="101" mass="11604" checksum="CB94A5C9AC5538E0" modified="2014-04-16" version="1">MFEHGLPSTTPKYEFKGIEDALQILDQELERHRQDTELSNPYTIFIMDERSFLDNMNVEENLFAQSCESYDPSIGHALIRLETGAHSVAIGSFFGMVECWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q9A3</accession>
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        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">PROQFM164_S01g000141</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
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                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
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                <person name="Lacoste S."/>
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                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="501"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="377"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="424"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="502"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM26332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="585" mass="65560" checksum="8B115C996E0F75F7" modified="2014-04-16" version="1">MAFQVPTHVPRRRTSYSTPPPPTLDIPSSLSEQRDDDTAQWVLFSPTARTHTTSTDRTRTVGASRLSDFGSFAATRSGIGAEGEADDENALDDQLDEDGTELDSLDDGLHAFRIPDLAPVSPTRFDQGPPAMLPAHDGLGSFQASSQAVQDQLWQHEQYNPQRPSYGHIQHHSHSSVQRYLDTVDEGETNVERERWQRIEEWRMDQSRALLQEIERETRQRRTSLTSRSSLRHSVDPSPQSRVSEVLSRDISLSKDVSEDEESFWRRITRTVIRDLIGIDDSLLSVIFGESLPLDAQPLPQEDPLDMETVLAREPEPEFSYSPLWQTKVLQTIAHELGILVHQICEHPGAFTTYYQMTKDISAEYAGMSLNRLAESGISQKPAESTASTVADTTGDSMLSPHFTPTLRDSNREHEAQWGIEDDDPKRSDQLSESIKLQHESEYWESGLDVMMVFRYLRNRFSRRGYMPNEAHTPTPPRRAQDASRRAAIIRQHHPLVARAYSRSQPQTRRASQFSGVSNTAGVSSPIVRPHRRPGSSCASQSAKLSAISSRRTMTSSSRNYWDIGGSESNSVIGVGAGLGTWGEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q9P8</accession>
    <name>W6Q9P8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Exocyst complex, component Exoc1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PROQFM164_S01g000306</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SEC3 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1365484.W6Q9P8"/>
    <dbReference type="OMA" id="SFMRVFP"/>
    <dbReference type="OrthoDB" id="27109at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="PH_Sec3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Exocyst complex component Sec3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028258">
        <property type="entry name" value="Sec3-PIP2_bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048628">
        <property type="entry name" value="Sec3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019160">
        <property type="entry name" value="Sec3_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16092:SF14">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 1 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16092">
        <property type="entry name" value="SEC3/SYNTAXIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15277">
        <property type="entry name" value="Sec3-PIP2_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20654">
        <property type="entry name" value="Sec3_C-term"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09763">
        <property type="entry name" value="Sec3_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01313">
        <property type="entry name" value="Sec3-PIP2_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst complex component Sec3 PIP2-binding N-terminal" evidence="6">
        <location>
            <begin position="88"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="71"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="207"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="613"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="675"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="212"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="223"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="263"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="295"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="322"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="351"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="410"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="454"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="520"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM26497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="1475" mass="163219" checksum="AF5D515C49CB569C" modified="2014-04-16" version="1">MVNGRDRPRGPPPGPPLNRGDLHSDSGSSPSTMTRGAAFEDEKKRIIHSCFAKKDEDGLLLESYITHVRITEDSAHPSSPSPPNGPPENKKPRIIIISVRKSGRVRIHKARENNEGTYSIGKTWMLDDLSAIQTFGSFVPRTPGEQQQKEWAGNVGFTVTIGKPYYWHARTSKEKEFFIGSLVKIYKKYTNGKVPNLVGFDDKERQMLSRHGQSGQPAQPAQPGGPPPRGQPPQPGGPPPRGPGPIPPTSDSSIPPSLQPSYRGRDTSRDGPREVKRKPSEDPTLRTQKSREQMSRPSTGSRPSTGHGRPAPSPFDLHKSPPHSLLSGPPLDQQPPPRAAERSATHAMPPSSLSESRGTDNLTVAAQSSNYADIPESLRPSSARSQDRGPKPPPLTTQPAPAKAPEFMRSNDTLRPTTSGSSNNENRDTVPRPTPSFGPKSPQRGGGDKAFTFNHPSLPQERSASDNLLAGAHAQPREPSSSPAIEGLAAEPAAIMAANLPSVEPIQPSNEKPKTPIETAPAADSPSQASSEQAGETGEFEPHRPGLGPMVKKKDAKDIAGAWKKAANAYAGFKPRIGGAGERLLAAAKKSQADLAGPDGITSVVPAPSLARSLTDPPQSPMVPKSEQDLQLPAPTVGPETPTVEITEPAPEEIAVTPVQTPEVSRENLSDVVVNVEDRSRSPSPATQGRRRRRREDHTMKYCQALGIDPGILDGRGIDFDDILTDLGWNGRLADEQKIEDLEADVRREIGRVEATSWLGNLEQQEGKVEQLASLIDRTIEECDELDGLLTLYSHELNTLHEDVAYIEAQGQGLQVQTANQKLLQNELQTLLKTLSISVTELGPLKEASLSNPDGLKDTESALATLYKAMVTIDSDIGQNKKRQVDASVGVYADTEIGQMRAIKQKKEEYRSIATMFLNRLQQFMALAFKMAEQKRLDWSNGAKDPMKLDSAARGHFRQEVWRYNALMLFAKEVSMTEWHSLVSLYEQQSKPSYQGDFRDNNLAWKNTARKPTGDEQELLFTHQEKEKEAEGLTMAARKLTVRRGKTVRAAAGLRLASGGGKKEGRAEPSEAFSGTLRETLNMMAQEQNFIIQFFHLDSLASADFSELVSAAIPENRSCPDFSANQPHDPDRAMAKRVEQIMDEIYSFWPTEMQNMVDWAMQADPLQGIGILYSLETAMNDFDDTNQEFILHALQKIHSRLMGLFNRFVDEQIRGIEDTKVKVNKRKGVISFMRVFPNFSNAVESMLSFPSGAFCDIRVSVNDAYDRINRAMWESLKFIAKEAPGQPPGVTAGGAGDPEDKEILNYHILLIENMNHYIEEVDVHNIPALERWTDRAHQDFQEHLRLYLDAVIHRPLGKLVDFVQSIDNLLAAGAKPTDIAARASHSRMVAKKVLTYYDNKETRRGIEMLKKRVEKHFGDADDPGLSRSLVVKVLRECENRYENTYDRIRQIIEDVYEGQVDLDWRKEETLSMFRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q9T9</accession>
    <name>W6Q9T9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Probable transposable element</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S03g000142</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q9T9"/>
    <dbReference type="STRING" id="1365484.W6Q9T9"/>
    <dbReference type="OrthoDB" id="4367135at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM33418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="51" mass="5749" checksum="A0FED288C9EA7D1C" modified="2014-04-16" version="1">MAPAALQRVSALFCTHKSSVQMLEMNPWVISMDCTYKTIRYGLPLLDKSTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W6QA66</accession>
    <name>W6QA66_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Ribonuclease H-like domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PROQFM164_S02g003422</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the REXO1/REXO3 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM33270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QA66"/>
    <dbReference type="STRING" id="1365484.W6QA66"/>
    <dbReference type="OMA" id="CGFMTVK"/>
    <dbReference type="OrthoDB" id="206335at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06145">
        <property type="entry name" value="REX1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000019">
        <property type="entry name" value="RNA exonuclease NEF-sp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034922">
        <property type="entry name" value="REX1-like_exo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047021">
        <property type="entry name" value="REXO1/3/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801:SF115">
        <property type="entry name" value="FI18136P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801">
        <property type="entry name" value="RNA EXONUCLEASE REXO1 / RECO3 FAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuclease" evidence="8">
        <location>
            <begin position="330"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="132"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="224"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="502"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="598"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="33"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="230"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM33270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="720" mass="79787" checksum="F5C812059268B6B0" modified="2014-04-16" version="1">MGKERKRKLSSDDPVGQPTAQVFGVADTLSRLQSDNPISEGSNGSHASKKRKRVDGEKVKYPDLTYVDGKLVSPIRIADLQGLLLYCFADGIAPQWISVKHSGHVRKVVVLMVPGLEMGMFDGTIPVQRASVTGEQETQEPKINAPEATEEVPKDEHAADYERWKQGLPLPDRSHRFNPRSITRENLPEPLQPLADMFPHIWPVKAPGDNKYNKVHSPLQAILMSSPPKTKNDDSRAKGARPAKVEKGFVPKRTPITAFVTSREDLLENDFILHPVFFSSDEEKSSQMEARQRGSQSVEDGWVDTQVPTLESALPPDIEIESGSVTVGRDIFALDCEMCITEGGQSELTRISMVGWDGEVVLDELVKPARPVINYLTRYSGITPEMLEPVTTTLRDIQQRLLTLLTPRAILVGHSLNSDLTALKLVHPFIVDTSIIYPHPRGPPLKCSLKWLTQKYQNKQIQNGMAGHDSVEDARAVLELVKLKCEKGERWGTSDSSNESIFRRLSRSTRPSHLPRPGEERTGAVVDWGNPERGFGAQATVSIGCLDDDAVVSGVSAVINGDESHPSIPGGGVDFAWARIRDLEYLRGWCSRLPDPNNANESTTLFPPPEETTPTTTSGNGDSTDLPRPDVLADTLSRTVSNISRIYDSLPACTLFIVYSGTGDPREVGRLQSIHKKHREEFRSGKPWDELTYKWTDVEEQALKKACERAREGCGFMCVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W6QAF1</accession>
    <name>W6QAF1_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S02g003152</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM33001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QAF1"/>
    <dbReference type="OMA" id="EEHANFW"/>
    <dbReference type="OrthoDB" id="4332324at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM33001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="317" mass="35851" checksum="CEF5D772A28372BB" modified="2014-04-16" version="1">MAGHRASDEFREEHANFWTLMQQIIHGLRNNYPSNQDKVIGWMGQLNLQLSTLRRAGEMMGLSYPPSDVVLDAPPQYFTARAQRHQNYFGTNFGYSCWYTQGQLGYAIADLLHQRDHTRVADQLEQLLVSWQLTEMRAFPRHLTTHNHVEHPADIVHIDVPPYYTPGAGRSKTETGPVRVHITMPAPTDTIYGVAQQTRHRPAPYLERGARPRHRGNARLIPPMPKMDLQLPNIMHNSDIRHAPLPTLPAVRSFFTPYSIPGHALFGIPNMSVPPLRGMQYPSIVPAPDTGDSLSVLNAHVGETLNKHLFCRDGVRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W6QAX1</accession>
    <name>W6QAX1_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="8">NADH-ubiquinone oxidoreductase 12 kDa subunit, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">nuo-12.3</name>
        <name evidence="8" type="ORF">PROQFM164_S02g003343</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM33191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QAX1"/>
    <dbReference type="STRING" id="1365484.W6QAX1"/>
    <dbReference type="OMA" id="GYQKNDP"/>
    <dbReference type="OrthoDB" id="10252718at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039993">
        <property type="entry name" value="NDUFB10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13094:SF1">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13094">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE PDSW SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0249">Electron transport</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="8" id="KW-0830">Ubiquinone</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM33191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="103" mass="11727" checksum="4166FAB8C1056C12" modified="2014-04-16" version="1">MPTAESAAFLAKKPTVAPTYEGVDFEDNVALHNARDAIIREQWVRSMMARLVGEELGKCYAREGVNHLEKCGVYRDKYFELLKESKIRGYLGMEKNRFGGQPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>W6QB95</accession>
    <name>W6QB95_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type DNA-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PROQFM164_S01g000781</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QB95"/>
    <dbReference type="STRING" id="1365484.W6QB95"/>
    <dbReference type="OMA" id="RDKGTEC"/>
    <dbReference type="OrthoDB" id="5244761at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053181">
        <property type="entry name" value="EcdB-like_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47785:SF4">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47785">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="182"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="263"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="390"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="475"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1048"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="267"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="324"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="400"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="475"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1048"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1065"/>
            <end position="1074"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM26972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="1074" mass="119557" checksum="8014994458FC2938" modified="2014-04-16" version="1">MNRMPPPEGHHAHAGSHVAYDPSWRPAYPPTFDNHLSDPRRSANPQTTLPPQPAGYPVMPNRELPQLTPEGPYGRPNGHGLPLHAPVHSPQDPIPQNFHQPMNGAPHEASPDYRPRMGYPPPDQISSAEHTPVSGALPPASQFMTPVAQMASATPPAGYDQAFYQNQTFGARQRKANRATQACDQCRARKAKCDEGRPNCSHCKENNLGCVYKEVPPHKQEKTTQLVLDRLSQIENRMEERDNRMDERFKKMQMQMQEQLLNKLGNQPPPTVQERPSLPPPPPLIKQDPPFKTEMPRPHAPTPNILDPGSQYSQFGQNLGPMDPRLEDQREAEGELSIPVEHTTAAHKLLMWPSIKRLLHPEQYDEDYVMRLEEERGLLSIYGQGEISYTADDSQLPMDGDSKGSKGVRPDGDGAGPDADVDIDEFGNMKLDAATARRYYDSYIEHMFKLHPFLMMGELNIKVDNFIRCYCRPNTSPSSASSYTRLARDGPPPAKRRRSNENLGVRGEFMQSIPNPPRPRVGKNIDNALVILCLALGAICEAPAPLPGPIMDKKIDYPNQRIPEPLPPFIPPPTLNGTYVTNGVLSPANSDSAAMQMSLSNSLYTVPTQPPGQSFPDSPLNKGIPGLSRRDVTNVQDEQGNTKNYQAIPGLTLYGYATAILGHLQGGNELEHVQCGLLAGLYAGQLAHPFQSHSWIYQASRACQVLVRTKRYERLEEGPTQDLYNFAYWTCLQLESDLLAELDIPASGISRSEGRMAIPKGKWTIILPNDLNAPQTMMMLFYSAQIHLRKVLNRVHTDLYKVEKQGQTRWSSTVQEALSLNLDLWRKSLPQSMQWDENDPPANEINAARMRAKYYGARYIIHRPLLYHALHYGHTGARVGPVGHSSVNSPTSQRLSPSMLHSARAPHMARMSSDIGSMPAAVSADWQPPKVRLQDLPRKLKGACDICIKSAIKSTEAFDGVGGHRLVVTNIFGTAHAQFGNMLVLSATFMSSLNELVEPEQLDRLLVRTIGFLIQSENISPTLRADARILTEIYTMIFHHPPDLRRVTSMSSHTPSMSSHTPSMNSQTTSMSFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W6QBD7</accession>
    <name>W6QBD7_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATP synthase subunit J, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">atp18</name>
        <name evidence="2" type="ORF">PROQFM164_S03g000747</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QBD7"/>
    <dbReference type="STRING" id="1365484.W6QBD7"/>
    <dbReference type="OMA" id="KPMWPFY"/>
    <dbReference type="OrthoDB" id="5520611at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006995">
        <property type="entry name" value="ATP_synth_F0_jsu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28060">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT J, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28060:SF1">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT J, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04911">
        <property type="entry name" value="ATP-synt_J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM34023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="60" mass="6331" checksum="FC52C5C9751CA797" modified="2014-04-16" version="1">MSLLGKKFPGALATPMTPFFAAGLIVLYGVNSLQNALSNTAQYKNDPRNVNAKPAGKADH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W6QBS2</accession>
    <name>W6QBS2_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S03</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S03g000225</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QBS2"/>
    <dbReference type="STRING" id="1365484.W6QBS2"/>
    <dbReference type="OrthoDB" id="5361958at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM33501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="228" mass="25861" checksum="335870ABCBEF6B94" modified="2014-04-16" version="1">MATPMASPIRLSPHVQCIQQSSPYTNIYDNAPVSPLRDLLPHSHPEQKRWENPGGWGARHLNDMAPFTLWDEQNHKFRHPSGQDWTWIRNKFGEGTVHISAWLICMETASPPQPIPLTLGTMPVIFVRPGEMFREPIPLSGYSNPRVPDPCPTVRWPQLTNPTKRQAVAVLTAIAPLARVRAAMFLPAWTIFELEFGDGRNYEKRSLPGSWQAEQHSTTTEINRFLAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W6QBU7</accession>
    <name>W6QBU7_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD-dependent pyridine nucleotide-disulphide oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S02g001774</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QBU7"/>
    <dbReference type="STRING" id="1365484.W6QBU7"/>
    <dbReference type="OMA" id="HMGHYAG"/>
    <dbReference type="OrthoDB" id="202203at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004174">
        <property type="term" value="F:electron-transferring-flavoprotein dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43735">
        <property type="entry name" value="APOPTOSIS-INDUCING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43735:SF24">
        <property type="entry name" value="NUCLEOTIDE-DISULPHIDE OXIDOREDUCTASE AMID-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17180)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="1">
        <location>
            <begin position="14"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM31624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="419" mass="46115" checksum="6CC9C567E2717008" modified="2014-04-16" version="1">MPSNDFVRTVSRNFRVLVIGGSYGGLSAALTLIDLSQGRLPRFNCNPDAKAPTHRIPIQITVVDKRDGYFHLIGSPKALACEKFAPEAWTRFQDIPGLKCPELKFIQGSVSSVDFNAKVANIVDAETNSNRTEPYDYLIAGSGLRRSFPTVPQSLRRDEFLKEARQHMTDVKEAREGVVIVGGGAVGVEMAAELKILNPDQKITLIHSRKRLLSSEPLPDEFAERVGTILRDTGVEVILGQRVIETTAVDGKNGTRTWDLTLSDGQKLRTGHVLNAVSRSVPTSTYLPKEVLNEEGYIKVHRSLQFSGAVPNAEHHWAVGDLTEWEGIKRCGGAMHMGHYAAMNIHQHMLAECTGGKPEYQTLEPFPSVMGLALGKTAVSYIPSEGTRDGEDLMKSLFGKDMGHTICWNYMRLGEACKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W6QC05</accession>
    <name>W6QC05_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 15">Alkaline phosphatase</fullName>
            <ecNumber evidence="3 15">3.1.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">PHO8</name>
        <name evidence="17" type="ORF">PROQFM164_S03g000320</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a phosphate monoester + H2O = an alcohol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15017"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:67140"/>
            <dbReference type="EC" id="3.1.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="13">Binds 1 Mg(2+) ion.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="13">Binds 2 Zn(2+) ions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the alkaline phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.1" evidence="3 15"/>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QC05"/>
    <dbReference type="STRING" id="1365484.W6QC05"/>
    <dbReference type="OMA" id="KAAGYMT"/>
    <dbReference type="OrthoDB" id="7392499at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004035">
        <property type="term" value="F:alkaline phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16012">
        <property type="entry name" value="ALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.60.40:FF:000002">
        <property type="entry name" value="Alkaline phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.720.10:FF:000063">
        <property type="entry name" value="Alkaline phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.60.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001952">
        <property type="entry name" value="Alkaline_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018299">
        <property type="entry name" value="Alkaline_phosphatase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11596">
        <property type="entry name" value="ALKALINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11596:SF5">
        <property type="entry name" value="ALKALINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00245">
        <property type="entry name" value="Alk_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00113">
        <property type="entry name" value="ALKPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00098">
        <property type="entry name" value="alkPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00123">
        <property type="entry name" value="ALKALINE_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 13 15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8 13 15" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphoserine intermediate" evidence="12">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="346"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="351"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="355"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="394"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="395"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="505"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR601952-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR601952-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CDM33596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="595" mass="64686" checksum="1C2DF30A1E2F52A9" modified="2014-04-16" version="1">MAREESLLPPRLSSDGSSIRNDEEDYALLTGERTTHQDKRRAWPSWREIGVFSWALVATILVIVLAAIYPHKSAEPHNHLASNTTWGPGGKPTGKRNMIFMVSDGMGPTSLSLTRSFRQYTHDLPFDDILVLDKHYVGTSRTRSSSSLVTDSAAGATAFSCGRKSYNSAISVLPDHSPCGTVLEAAALAGYKTGLVVTTRLTDATPACFAAHANLRNYEDLIAAQEVGEHPLGRVVDLLLGGGRCHFLPNSQAGSCRSDDHDLVKVASQNGFGYIDDRAGFDSLKGGDNVSLPLLGLFASGDIPYEIDRRTQNDIYPSLEEMTRTALKALSKATEDSEQGFFIMIEGSRIDHAGHGNDPAAQVHEVLAYDKAFAAALEFLENDSTPGVIVSTSDHETGGLAAARQLHKSYPEYLWLPNVLEKANHSGEYLAAQLKEYLSGPGKDAEDLSKQSWIRQTLKDGLGIDDASKDEVNTLLHPDPEVTTAYVFADMISRRAQVGWTTHGHSAVDVNIYASSTKDAWPLVGNNENTDVGDFLADYLDLNVDNVTKLLQDTKSGSDWMGDRLGLNFHAEGLDTYHGDFRKRSADDCGCGAIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W6QCU7</accession>
    <name>W6QCU7_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Six-hairpin glycosidase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S03g000999</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QCU7"/>
    <dbReference type="STRING" id="1365484.W6QCU7"/>
    <dbReference type="OMA" id="EDGGHNF"/>
    <dbReference type="OrthoDB" id="2305845at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010905">
        <property type="entry name" value="Glyco_hydro_88"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052043">
        <property type="entry name" value="PolySaccharide_Degr_Enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33886">
        <property type="entry name" value="UNSATURATED RHAMNOGALACTURONAN HYDROLASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33886:SF8">
        <property type="entry name" value="UNSATURATED RHAMNOGALACTURONAN HYDROLASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07470">
        <property type="entry name" value="Glyco_hydro_88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM34275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="367" mass="41799" checksum="BF7ACB6797C9444E" modified="2014-04-16" version="1">MSSPKPTGAQIHNAVNLLIDNLVNIKDETGKFLLPLPDGRIIDTKSWQGWEWTHGIGLYGVWKYYELTGDERLLRIIEDWFAARFAEGGTTKNINTMAVFLTLAYVYEKTGNVTYLPWLDAWAEWAMHDLPRTRYGGMQHMTYITENYQQLWDDTLMMTVMPLAKIGKLLNRPQYIEEAKKQFLTHIKYLFDTKTGLWFHGWSFEHGGHNFADARWARGNSWVTIVIPEIIELLDLQPNDPIRLHLIDTLEAQCEALQRLQSSSGAWHTLLDHPDSYLEASATAGFAYGILKAVRKRYIGAQYRPVAEKAISAVMGYVDEKGELQNTSFGTGMGECLYFYKTIPLTSMPYGQAMAIMALGEALRGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W6QCY5</accession>
    <name>W6QCY5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S03</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S03g001044</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QCY5"/>
    <dbReference type="OMA" id="DAPRHYL"/>
    <dbReference type="OrthoDB" id="5419162at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM34320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="81" mass="8898" checksum="45F0DB01D291370A" modified="2014-04-16" version="1">MSSLGEAKDVNLSIEEEVNARRGYSAKSKDNALDLLNDELDGDTPRHYRDEVPDQSTDSSGLVGVEKAAPEYHDNSESEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W6QDG9</accession>
    <name>W6QDG9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Genomic scaffold, ProqFM164S03</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S03g001249</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QDG9"/>
    <dbReference type="STRING" id="1365484.W6QDG9"/>
    <dbReference type="OMA" id="YNKNMAD"/>
    <dbReference type="OrthoDB" id="5238236at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046539">
        <property type="entry name" value="DUF6604"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38795">
        <property type="entry name" value="DUF6604 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38795:SF1">
        <property type="entry name" value="DUF6604 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20253">
        <property type="entry name" value="DUF6604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6604" evidence="2">
        <location>
            <begin position="12"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM34525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="857" mass="97611" checksum="D59D039FD10B9052" modified="2014-04-16" version="1">MLPKFLQSSYIRYKDDTNSFATWLLKAAGKCGYQPQGLTSTAPTSKNGKNKSRNKAANDSDPVQYTMTVKDLQLLADVVAKSALTVPTQVLIIVKRAIKLRKHVTSWFLGQGDSDNNKRHTHFISALEKVCETLEWKMNNSSNPDSNQPPPTSESGGGDADLDMFLNKFAVLTVEEPQETQEGQQKSPESKQVVKVEIVENDEDEDTSYFRLIFFKTYCMFQDLNNMRAFISHTWSEYRDNKIDLMNAAIVTDSALQLARDLVQEVVDDWSTSTPSIDNLQEMVFNVACFTRGIDATPSIEIGLPYNKHMSDVAEWCYLPTRILLESFRDVLQDNHLPVFKKGFFGTYDPKANREGMSVGQKFNEDKIIFVQLMPEFCMIDKFGIRMLTSDAITAGLVEFCRTKKATLWLSFAAQVLLDVHHIMRYSILGAFDDLRMSGLRITKTIDDYFKGTKSHPQPQFWPKEGDEEIKDIHFTVASWIIQDPFLERKRVSIPGYDVSEKHVLFSQHAILCGLSLFHLNTRMQSVGQQLVTQWYDVQQLAFLYNLANTDGHMNLIWPDMEAFIKIHGESHIFIGSRPKNASESLNRLELATGISSAAKFARGSRKRQDFHRPDGKNPRVLTPTTTIANLFRAQYVSGFREEDGIRTIDNVLDTLSQEPCLRETSKELQPSDLQVMFQQKWSHTRNIGTLQLLTLLKSRLSKEEPLLLFNYFGMHKRSLELLRLIRAKEHHKFVQYFTTAYMPDESLISNIVILVHHVARGSAQNARALGMSSMGNGSQICSRIVMSCGEVMRDYLRKNGDVACKELRVFCKNKKPIQDEIDYDKGRSEEFGYWFGIEEALDPKVLASLMTGIPIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W6QEA4</accession>
    <name>W6QEA4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Oligopeptide transporter OPT superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PROQFM164_S02g002685</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QEA4"/>
    <dbReference type="OMA" id="QLAYRII"/>
    <dbReference type="OrthoDB" id="9986677at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004648">
        <property type="entry name" value="Oligpept_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22601">
        <property type="entry name" value="ISP4 LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="307"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="407"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="462"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="489"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="646"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="685"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="722"/>
            <end position="744"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDM32534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="770" mass="87475" checksum="A8F89B1242CD3BB7" modified="2014-04-16" version="1">MTGKEAKELPTETVQPIEIKNLASINKEEVDSFDESQYDFDSAEFKNIPELVRTVVGFEDDPELPVLTFRSILLSALFCAIGSIVSQLSYFRTTYAPFPVFFVILASDPLGRFMARVLPAYRVPLGRFSFSLNPGPWSNKEHAIVGIAANAGSQGQWATFLPTNAALYYNITMNPAVALFFGWGCSLLGFAFAAMVRGVLIDDPEFIFPLSLQQVTLYRSMDAKNRPDQKRAREQVKVFWILLLATFVWQFLPEYLFPFVASLAPLCWFASRNHTVNFIGAGRGGMGLLNITLDWSNITSVVITYPYSVQVIIFLAFVLTCWILIPIAYFGNLWGSPTFNIMSNGVFMKNGTTYPFNDLSGYLAMTFREYADYFQVYLDSNGMQHFNETKYDEVGLAYSGAQYTWQMFMWVASYMSSFAWCGLFLGPKIYRMWKARKQAGSYHQDRLSRIIQRYPGMTKWEWAALTLIPFLMLLGVVVSKTVYMPIWTYFVALGFGAVSMLPMSFVYAMSGFSIKVGYFNELVYGYMIDAKGSSRHPLGQLAYRIISGNVWYDARTVLEDQKIGHYLHLPPRQVIGIQIIANMLALPVNYGVMRWVIATKFDYVSGKEKDPLGQWTGQDFQSYNTAGIQYALVGPRKLFASAFFRPILWGFLAGALAPGVMWLLHKKFPRARFDLWNTTIFFASAAVFYGNLSTGPFTTFLVGTFTNFFLYRYRRVFWNKWAYISGAALDTGFNANLLFIFIFFGTTGTKMVHWWGNNADSIERCFALKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W6QEH4</accession>
    <name>W6QEH4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Short-chain dehydrogenase/reductase SDR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PROQFM164_S03g001592</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QEH4"/>
    <dbReference type="STRING" id="1365484.W6QEH4"/>
    <dbReference type="OMA" id="SHVDEWR"/>
    <dbReference type="OrthoDB" id="153074at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050664">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05367">
        <property type="entry name" value="SPR-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000281">
        <property type="entry name" value="Uncharacterized oxidoreductase YIR035C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008">
        <property type="entry name" value="BENZIL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008:SF8">
        <property type="entry name" value="BENZIL REDUCTASE ((S)-BENZOIN FORMING) IRC24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="4">
        <location>
            <begin position="4"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDM34865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="253" mass="27309" checksum="4DEB2675DBC2D11D" modified="2014-04-16" version="1">MAAKTIIVTGASRGIGLAVAKYLLTAPQSHNVVVVARSVEPLQKLKEQYGNQVAILNGDLSDFSLAQQAVDKAIKTFGQLDGMVLNHGLLGQVGKIADADPQQWKEGFDVNFISLVAFAKAALPALRESKGKIIFTSSGAAVNAYRGWALYAATKAAMNNFAMSLGAEEPDVTSVSIRPGMVDTEMQRALREDHGTALDAEMHSKFTGVHKNGKLLKPEQPGHVMAKLVLDAPKEISGRFYSWNDKELEVFQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W6QG65</accession>
    <name>W6QG65_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="8">TAFII55 protein, conserved region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PROQFM164_S02g003336</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF7 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM33184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QG65"/>
    <dbReference type="STRING" id="1365484.W6QG65"/>
    <dbReference type="OMA" id="KWEKMQN"/>
    <dbReference type="OrthoDB" id="153872at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08047">
        <property type="entry name" value="TAF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037817">
        <property type="entry name" value="TAF7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006751">
        <property type="entry name" value="TAFII55_prot_cons_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12228:SF0">
        <property type="entry name" value="TATA-BOX BINDING PROTEIN ASSOCIATED FACTOR 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12228">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID 55 KD SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04658">
        <property type="entry name" value="TAFII55_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01370">
        <property type="entry name" value="TAFII55_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TAFII55 protein conserved region" evidence="7">
        <location>
            <begin position="141"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="363"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="17"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="397"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM33184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="477" mass="53289" checksum="441AB098CEC788FA" modified="2014-04-16" version="1">MPPLKIKFSRRPDPPEEPAPIPAPVPAPAPAPAPAPPAETPQAPRKITLKIARKPQPESEEKPKKKKSTKKRPAETAALPELEHEPEPETSQQIPKRIKLIPSKKPALQSIRIKNKGIVPNRPVGVGYDSEASDTELDPSIEEQFILRMLPGEDCDIIRKVINDRTFKNGDVGIKPLTREGRRSIVNVRGHQYAAALVDLPCIIEGMKSWDRRGWYKSADICQMLLVLGRVNSDQEAMEYPLPPGVDSPDEKTLQYAHGIAPPLRWVRKRRFRDRVSTRTIEQVEKAVEELMAQDDNSIFPPKFELVDSTSLNRVEGLVQSGGYGDEYDDEQDAYGEAEEEMMDDFEDALAAEMEAALAAGDDEAPGAPEQAHTTSQSFTPAGGPTERGDTSADESNISDEDEEDELDDDQIEQQQQLQQQREEVAELEALIKTETAQWEKVQNHILRNKMGRRIQELKKDLQLKKVSMGMPAGDDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W6QG82</accession>
    <name>W6QG82_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L41</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PROQFM164_S04g000689</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM164</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4">Component of the large ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the eukaryotic ribosomal protein eS32 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QG82"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007836">
        <property type="entry name" value="Ribosomal_eS32"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05162">
        <property type="entry name" value="Ribosomal_L41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 4 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00043969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU368055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDM35808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="46" mass="5878" checksum="F2D8D81679A428A0" modified="2014-04-16" version="1">MRLGPPTLHLSFYYLCFILEIMRAKWRKKRTRRLKRKRRKMRARSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W6QGB2</accession>
    <name>W6QGB2_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type DNA-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PROQFM164_S04g000331</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QGB2"/>
    <dbReference type="STRING" id="1365484.W6QGB2"/>
    <dbReference type="OMA" id="YHDVWIA"/>
    <dbReference type="OrthoDB" id="4220372at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053175">
        <property type="entry name" value="DHMBA_Reg_Transcription_Factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="10"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="60"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="154"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="447"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="84"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="161"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="447"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM35450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="688" mass="74778" checksum="EDD9080F878BD37F" modified="2014-04-16" version="1">MVYCGRPSTSCSNCRAKKRRCDKAVPECGQCCRTGQKCPGYRDPLSLVFRDESTQVINRARSKVSKRTSTGTPTDRLSVERTDPSQAQNQQQNTSTPDYHVSRPSDVVDETMLEMSDFDVGAGMFAGGSFMPELMSFNDPFNLDETGLFSLHQDASPSAMPVSGDGPGSAASVSASASGRRSRVGASSVGGDDVALNQFPDDSSNRGDRQRLGHNNFTSSQPEVIARPFSVPLVITGLNFFLSRYVVRQSGPSSGFFDYAPAMLAQDDGGKDMLEGAILAVGFSGLARTTSQADLLTRSMMMYTRTMERVNLALADPQAACRDSTIVSVLVLALYEFSRASIDGWKHHIEGATLLLNLRGRSQFSTSTGLQIFKDVFSQLLTNCLRAGSPIPSSLRMLRIEAGNAISVSDPYWVACSGIVELLDLFQHISPGGYSFFPNSYGAPSAPAAPSNSSNSPSTASGSSPASTSMLSGPLEGANISIEHLERYLSQVLEIDYRLESAFSKCPCEWQFTDKSNSSSSNYDPTGIRRDANHIYHDVWIASIWNGMRICRILANHAISHLLLRGANIDSNWFFANNYTDRLHQATQTIVRLRDEMLASVPQLMGYATSPAQELQQHTHSKNNAGSAVGGYYACWVLLTVGCMHNLSHETRAWTAAQLRRISCQAGLAQADDFANLVQSSNLRPPLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W6QH51</accession>
    <name>W6QH51_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WW/Rsp5/WWP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S04g000157</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QH51"/>
    <dbReference type="STRING" id="1365484.W6QH51"/>
    <dbReference type="OMA" id="MLKSTYT"/>
    <dbReference type="OrthoDB" id="410044at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070063">
        <property type="term" value="F:RNA polymerase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.440:FF:000035">
        <property type="entry name" value="Putative ff domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.10:FF:000049">
        <property type="entry name" value="Transcription elongation regulator 1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.440">
        <property type="entry name" value="FF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002713">
        <property type="entry name" value="FF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036517">
        <property type="entry name" value="FF_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045148">
        <property type="entry name" value="TCRG1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15377">
        <property type="entry name" value="TRANSCRIPTION ELONGATION REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15377:SF3">
        <property type="entry name" value="WW DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01846">
        <property type="entry name" value="FF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81698">
        <property type="entry name" value="FF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="WW" evidence="3">
        <location>
            <begin position="10"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="3">
        <location>
            <begin position="124"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="165"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="502"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="93"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="105"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="165"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="212"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM35276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="567" mass="65627" checksum="9B2AA9D4D3BF1723" modified="2014-04-16" version="1">MLRSTYTAPPPLPSGWTQHRAPTGHLYYYNSSTKQSTYTRPQETAPQTIQAAPDTPEATYNPETLPPFSSTPYGPIGFASGPAQFSPPQNSRGRGGFRGFRGGRGYHDHGRRETEDRPRAKHPIPDCAPWLLVKTKLGRRFVHNPETNESFWKFPEQVLKGVVEFDRLEREKKERKERGEPEVPAKKEPPSPQHGRIEPEPIPQEAERADYDSDYEEVEVTDSEGEEGQPSKRARAESEGVKDQPLEFNEEDMAYQLAAMGEDYGLDPGEYGEVGEEDWEEGAEGLPLTEADAEALFRDLLDDFRINPFTTWENVIEEGRIIEDTRYTAPSNMKTRREIFSNWTRDRIQDVREQKAKQEKTDPRIRYLAFLQEHATPKLYWPEFKRKYRKEPEMKDSQLGDKEREKFYRDHISRLKQPESTRKSDLSALLKSVPLDLLHRSSNLEALPTIIITDIRYIGLAPEVRNPLIEAYISTLPPAPEVQMTAEELEEVDRKRIEREKRERALADREKRVEEEKRRQRGDLLRSKHLLREGEAEIEQAMHVNKDGLMSYMDIDQAVDEEQKPSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>W6QHQ0</accession>
    <name>W6QHQ0_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Zn(2)-C6 fungal-type DNA-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PROQFM164_S04g000836</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QHQ0"/>
    <dbReference type="STRING" id="1365484.W6QHQ0"/>
    <dbReference type="OMA" id="CIRIACW"/>
    <dbReference type="OrthoDB" id="654211at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF1">
        <property type="entry name" value="TRANSCRIPTION FACTOR WITH C2H2 AND ZN(2)-CYS(6) DNA BINDING DOMAIN (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="35"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="11">
        <location>
            <begin position="105"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDM35955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="652" mass="72893" checksum="142AB0F40B00B3C3" modified="2014-04-16" version="1">MEFVHALTRNRPLPTAPFPFLSHSDCNNTGVDVMFQCTQCEKAYQRKTHLIRHEVTHTQQLSSSCPLCSKSFLKPEVTRRHIKNCAKKFNQPAPPAAKPGRKRHSCDLCYFAKASCDRNLPCSRCRSFGRECTFVTQEISGDPSCSAVTSLSPSITTSRANSRDSGSFSFLQHFANPSFQRDRLAIGETAKCSVRRNLETLNSHIEDALVPTDPMSAFDGDFQLTNLSFQVPSTLPSFTDDYLLQFNPDTLFPSKLSNQLSEIMTELVDTSKSMGLGSTGTLSPLDFMELSTLLGVSNISASISAFFHSLHWHLPVVHFPTFDPGNISNALLLAIFLSGATYTIPLDGGALPSGLFDVAEEYIFRKIADLSTLTSPKDQSHLLSNVQLMQSALIIEMLQFGQDSMQTRRRIRIVRHPCLVSTIRSLGIFQLKRGAAPTVCDEMTWRNLVAEEVCIRIACWVFLADGFLTVCFKNHPSISVFEMDCHFPWSAGLWEAESASSFSRIAMSHSTELPLPPLKDVITQLLETPLGNDPIPWSLSVSVEHLLILIYAINSLAFQARAGLLRYLSLDRIRCASSNWRRIWDSVIGLLDKDQFLHLGYPKHAQELWWLLNATLDATGRSDVSLRYMDNTATDDLGNLNEFIQWCHQSPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W6QHR5</accession>
    <name>W6QHR5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Calcium/calmodulin-dependent/calcium-dependent protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S04g000851</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QHR5"/>
    <dbReference type="STRING" id="1365484.W6QHR5"/>
    <dbReference type="OMA" id="KGIFLEY"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24359:SF1">
        <property type="entry name" value="INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE EPSILON SUBUNIT HOMOLOG 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24359">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE SBK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="7"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM35970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="336" mass="38919" checksum="C77A3BE1195BE8DC" modified="2014-04-16" version="1">MDIKDQFPSVHWIWKGGISFVYEVDPRIAVKVPQSGEEEREQFSKEVEIYRIFSQNPPCPFIVQCFHISDKGIFLEYMRDRSLFSRIQDNHTWNRQNMVVTKVEKLEPLSLRKEWMNDLAQAVAFLESLNLAHGDLRPENILFDRDRLKLSDFDCTAKIGMGHEACIGPYGRFLNSNEPDEGICGSSGSLGSRTEQFALGSLYYYINYGFEIYGDRCLTEDPYDHGPKTVDLLQNMEFPELNGNPRIDDIIDKCWHNKYGKVSDLALDTNRFLNEGTEAEGSIRVGHREEGNRKEFLLKKELCQDLEKRGLLDLLSSGEPKKIGFECRLYRYRMKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W6QHX5</accession>
    <name>W6QHX5_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Exocyst complex component Sec8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PROQFM164_S04g000911</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SEC8 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM36030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QHX5"/>
    <dbReference type="STRING" id="1365484.W6QHX5"/>
    <dbReference type="OMA" id="WYKAIVT"/>
    <dbReference type="OrthoDB" id="272977at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006904">
        <property type="term" value="P:vesicle docking involved in exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090522">
        <property type="term" value="P:vesicle tethering involved in exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039682">
        <property type="entry name" value="Sec8/EXOC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007191">
        <property type="entry name" value="Sec8_exocyst_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048630">
        <property type="entry name" value="Sec8_M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14146">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14146:SF0">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20652">
        <property type="entry name" value="Sec8_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04048">
        <property type="entry name" value="Sec8_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="3 4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst complex component Sec8 N-terminal" evidence="6">
        <location>
            <begin position="181"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="Exocyst complex component Sec8 middle helical bundle" evidence="7">
        <location>
            <begin position="434"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="582"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="642"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="14"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="73"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="95"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="106"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="120"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="585"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="648"/>
            <end position="661"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM36030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="1215" mass="135379" checksum="7BDFE498E9321496" modified="2014-04-16" version="1">MSGQSGYGNGYGYSGPNQYGNDGGYSSNSNPGGTGYGGLGAAPPPGGGGHSDRRPGGYGGFYADTPQPADLSPGQSPALSQSPDRRRDRTNRQPSPQPSSNPSPHPSSNSAKASSRSRTRNQDPDRKHREERSRDASRRDQRDGRSQRDQRDPRGQMEHRSQRNASPVAKVSNDSGETQAIETILHSIQRDWDFMTDAECVPVHVALSLMDTSTLGKADREPEFLHMYNDIQKTLKAIVNEHHQGFNSSIGTYHKIQSNIASSQNRVRSLRNALDQAKSGLISTKPELKGLATSSQNYDDIVQLFTQIEEIQSLPEKLETQISDKRFLAAVDVLHTALRVLRRSELEEIGALSDIRAYFLNQETSLTDILIEELHDHLYLKSPYCSDRWKANTTDGKDVHTSHLAGSHSWERPVYSFLAKFDPLTPMVEDASRNPEADTFSYIQLLIEALNKMGHLDVAVHRIEQRLPVELFAVVDKTNGEVDTRYPEPTKSFSAQDNYKQSSLPTEIIEKRGHVLSEFLWALYAKFEAIVEGHRIVHDVVAAIVDREGLIKSEALSGGFKELWKLLQSEIRSLMHDYLATDGDSSFRSRTEENDPRHHQYTGNRDKNKKMFKLSDIEHNSEMKAEQDELDEILKSSVPGLVSKSRQKATTSDTPHPTNGNSGTGHKILLEPSVFNMGILLPPSLSFIQRLKDIVPVDSDISMGTLTSFLDDFMVNVFLPQLDETVTDLCTLSFIGADAFTEDPHWAKASPRPIFKGTVKFMSIVREFSKMLSSIPHDQAFTQLLIDQIVTYYDKCCGWYKAMVTKISARNRGGEVRLKAAAAFAETGDIHDVVDELWKGAGDKKKTLIDTEIDLLLKRTTEVPLEPYDIISDPKTVISLSLLYNSMQWLASHLARIRLVVEHTADSESSSLTATGRPSRRWTLFGSMKPNRDSINNPVHLPLNQETAVAFDGTIHSLHRLADTALLTMHVDIRCGIIHMLTKTMAGPNPPNLRNSEPVTPSPNVIDNWWHIIMNQPTAASPTILALNNDLIAFDTNISTYLGSVERWFITSGLARFIDRVFVACTQYIGAMNENGALRLQLDVLVLQQNLKNIIIDPAGDSPDSATYLHAQASQEIVALPRSAKFLDWFLEGAEKALDYAKEEKEAFASQGAKALAAGNGEPFTYEELRVLVDLCFSEFLRGPRGAENREEFMSAKKASADALLRLNEIMWDAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W6QI46</accession>
    <name>W6QI46_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S05g000321</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QI46"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM36488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="50" mass="5610" checksum="BF5D8E21B9CEC152" modified="2014-04-16" version="1">MIDTAKCTRAMSTQPNPNQQLEVLERNEVYEDSDEGLKASISQVPSLCIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W6QIG1</accession>
    <name>W6QIG1_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Probable mannosyltransferase KTR4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">KTR4</name>
        <name evidence="5" type="ORF">PROQFM164_S01g003179</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 15 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QIG1"/>
    <dbReference type="STRING" id="1365484.W6QIG1"/>
    <dbReference type="OMA" id="WCFFLYQ"/>
    <dbReference type="OrthoDB" id="439943at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000032">
        <property type="term" value="P:cell wall mannoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000051">
        <property type="entry name" value="Alpha-1,2-mannosyltransferase (Ktr4)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002685">
        <property type="entry name" value="Glyco_trans_15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121">
        <property type="entry name" value="ALPHA-1,2 MANNOSYLTRANSFERASE KTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121:SF7">
        <property type="entry name" value="MANNOSYLTRANSFERASE KTR4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01793">
        <property type="entry name" value="Glyco_transf_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004882066" evidence="4">
        <location>
            <begin position="31"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDM29367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="393" mass="45904" checksum="305EF420779859FA" modified="2014-04-16" version="1">MAIARPIRMLGAACILLCLFLVFQLHQSSSEEGSKLPHGMKKDPLVDPTGEPVGNLWRADEHDYSPNSEQSARTNAALITLVRNEELGQLLSTMTDLERTWNSKFNYPYIFFNDVPFTDEFKQKTQAMTKAKCQYELVPKEHWDVPEWINMDLFRESAKLLEEQDIQYSSKVSYHQMCRWNSGMFYKHPALENYRYYWRIEPNVKFFCDVDYDVFRYMEDGNKTYGFTINLYDAPQSIPTLWPETQRFLAANPSYLSDNNMWEWITDDVARPEHTKAANGYSTCHFWSNFEIGDLDFFRGEKYEAYFQHLDRAGGFFYERWGDAPVHSLGIGLFADAANVHWFRDIGYNHIPYLNCPNSPKCSGCKAGQFFQGADFLSKEDCRPTYFKYVGTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>W6QIN0</accession>
    <name>W6QIN0_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosome-interacting GTPase 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">RBG2</name>
        <name evidence="5" type="ORF">PROQFM164_S01g003264</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QIN0"/>
    <dbReference type="STRING" id="1365484.W6QIN0"/>
    <dbReference type="OMA" id="DVCDQVH"/>
    <dbReference type="OrthoDB" id="603at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903833">
        <property type="term" value="P:positive regulation of cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01896">
        <property type="entry name" value="DRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000003">
        <property type="entry name" value="Developmentally-regulated GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000740">
        <property type="entry name" value="Putative GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045001">
        <property type="entry name" value="DRG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031662">
        <property type="entry name" value="GTP-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006074">
        <property type="entry name" value="GTP1-OBG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43127">
        <property type="entry name" value="DEVELOPMENTALLY-REGULATED GTP-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16897">
        <property type="entry name" value="MMR_HSR1_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="TGS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00905">
        <property type="entry name" value="GTP1_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="3">
        <location>
            <begin position="68"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="TGS" evidence="4">
        <location>
            <begin position="295"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDM29452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="371" mass="41156" checksum="6C9917A56DFED317" modified="2014-04-16" version="1">MVNITEKIKEIEDEMRRTQTNFQISISEHHLGLLKGKLARLRAQLLEPVGGAGGGPGAGFDVSKSGDARVALVGFPSVGKSTFLSKITKTKSEAASYSFTTLTAIPGVLEYGGAEIQILDLPGIIEGASEGKGRGRQVISAAKTSDLILMILDATKRAEQRALLEAELDAVGIRLNKEPPNIYLKIKKAGGMKISFATPPKHLDEKLVYNVLRDYKILNCEVLVRDENATIDDFIDVIMKDHRKYIRCLYVYNKVDSIGLEFLDALAREPHTAVMSCELDLGVQDVVERIWKELRLMRLYTKRKGEEPKFDEALIVRKDSTIEDVCDQIHRTIKDTFKYALVWGASARHVPQRVGLGHLVADEDVVSIVAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W6QJ64</accession>
    <name>W6QJ64_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S04</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S04g000942</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM36061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QJ64"/>
    <dbReference type="STRING" id="1365484.W6QJ64"/>
    <dbReference type="OrthoDB" id="5985073at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM36061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="67" mass="7440" checksum="E37A49FEADE209FD" modified="2014-04-16" version="1">MDNSSRNCSQWYSVQEGDTCAQVSLAQSMSLTDLYFLDLDDAYCVKAVGSITSYPTYTVTGYLLAYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W6QJA3</accession>
    <name>W6QJA3_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Nucleoside diphosphate kinase</fullName>
            <ecNumber evidence="3 11">2.7.4.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">ndk1</name>
        <name evidence="13" type="ORF">PROQFM164_S01g003479</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a 2'-deoxyribonucleoside 5'-diphosphate + ATP = a 2'-deoxyribonucleoside 5'-triphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:44640"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9 10">Belongs to the NDK family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.6" evidence="3 11"/>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QJA3"/>
    <dbReference type="STRING" id="1365484.W6QJA3"/>
    <dbReference type="OMA" id="QHYGEHK"/>
    <dbReference type="OrthoDB" id="2162449at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004550">
        <property type="term" value="F:nucleoside diphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006241">
        <property type="term" value="P:CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006183">
        <property type="term" value="P:GTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006228">
        <property type="term" value="P:UTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04413">
        <property type="entry name" value="NDPk_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.141:FF:000002">
        <property type="entry name" value="Nucleoside diphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.141">
        <property type="entry name" value="Nucleoside diphosphate kinase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00451">
        <property type="entry name" value="NDP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034907">
        <property type="entry name" value="NDK-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036850">
        <property type="entry name" value="NDK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001564">
        <property type="entry name" value="Nucleoside_diP_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023005">
        <property type="entry name" value="Nucleoside_diP_kinase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001908">
        <property type="entry name" value="PRK00668.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11349">
        <property type="entry name" value="NUCLEOSIDE DIPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00334">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01243">
        <property type="entry name" value="NUCDPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00562">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54919">
        <property type="entry name" value="Nucleoside diphosphate kinase, NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00469">
        <property type="entry name" value="NDPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51374">
        <property type="entry name" value="NDPK_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 11 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nucleoside diphosphate kinase-like" evidence="12">
        <location>
            <begin position="5"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="active site" description="Pros-phosphohistidine intermediate" evidence="9">
        <location>
            <position position="119"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDM29667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="153" mass="16617" checksum="171B5B2B9264113C" modified="2014-04-16" version="1">MSANEEQTFIAIKPDGVQRGLIGPIISRFENRGFKLVAMKLTSPSQEHLEKHYADLATKPFFKGLVAYMLSGPICAMVWEGKDAVKTGRVLLGATNPLASAPGTIRGDFAIDVGRNVCHGSDSVENAKKEIALWFGASEVLKYTSAQAAWVYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>W6QJJ6</accession>
    <name>W6QJJ6_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">acetyl-CoA C-acetyltransferase</fullName>
            <ecNumber evidence="4">2.3.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">erg10</name>
        <name evidence="13" type="ORF">PROQFM164_S05g000019</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM164</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="8">Metabolic intermediate biosynthesis; (R)-mevalonate biosynthesis; (R)-mevalonate from acetyl-CoA: step 1/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.9" evidence="4"/>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QJJ6"/>
    <dbReference type="STRING" id="1365484.W6QJJ6"/>
    <dbReference type="OMA" id="ICPSIAI"/>
    <dbReference type="OrthoDB" id="5404651at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003985">
        <property type="term" value="F:acetyl-CoA C-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000007">
        <property type="entry name" value="acetyl-CoA acetyltransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18919:SF165">
        <property type="entry name" value="ACETYL-COA ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18919">
        <property type="entry name" value="ACETYL-COA C-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0630">Potassium</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase N-terminal" evidence="11">
        <location>
            <begin position="7"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase C-terminal" evidence="12">
        <location>
            <begin position="276"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="9">
        <location>
            <position position="92"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="355"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDM36186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="399" mass="40767" checksum="5B8DC2FFE65D7E2C" modified="2014-04-16" version="1">MSSLPPVYIVSTARTPVGSFLGSLSSLTAPQLGAHAIKAAVERAEGINASDVEEVFFGNVLSAGVGQNPARQCALGAGLTDSTICTTVNKVCASGLKAIILGAQTIMTGNADIVVAGGTESMSNTPHYLQTSRSGTKFGSQALVDGIQNDGLTDAYGKHDLMGVAAEECAAEHGFNRTQQDDYAIRSYEKAQAAQKSGAFDNEIAPIEIPGFRGKPGVTVSRDEEPKNLNPEKLRAIKPAFIPGTGTVTAPNSSPLNDGSAAVVLVSEAKVKELGLKPIAKILGWGDAEQQPSKFTTAPALAIPKALKHAGVSQESIDAFEINEAFSVVALANMKLLGLSEDKVNIHGGAVAIGHPLGASGARIVSTLLGVLSAKEGKLGCVGICNGGGGASALVIESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W6QL63</accession>
    <name>W6QL63_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transcription initiation factor IIF subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PROQFM164_S03g001661</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the TFIIF alpha subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QL63"/>
    <dbReference type="STRING" id="1365484.W6QL63"/>
    <dbReference type="OMA" id="IPIMTTK"/>
    <dbReference type="OrthoDB" id="76676at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005674">
        <property type="term" value="C:transcription factor TFIIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001096">
        <property type="term" value="F:TFIIF-class transcription factor complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008851">
        <property type="entry name" value="TFIIF-alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011039">
        <property type="entry name" value="TFIIF_interaction"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13011:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIF SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13011">
        <property type="entry name" value="TFIIF-ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05793">
        <property type="entry name" value="TFIIF_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50916">
        <property type="entry name" value="Rap30/74 interaction domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 7" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="127"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="392"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="127"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="149"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="172"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="198"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="393"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="415"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="443"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="453"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="506"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="559"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="583"/>
            <end position="597"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM34934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="694" mass="77048" checksum="261F5D26C3D69790" modified="2014-04-16" version="1">MSTPTNPSNARTPTGPNGAPLMRMRRPKAADPLVRPKRRPVPRPAGATPAGNGVATKTLPSRPQRPHNQAIFPSERPMLELSNNHMAANGFSGPLLSDKYVDYPVVTTKRALMEGLKHHIARFASKKSVDPRDESQFTRPVRLHRRDPRSRTHDPNSGRSEIDGQPMDEAEREAFDARKAAREKERAENLSQIAPALGSTSKRPNAPKQKTQQVFKSDMTPEEIARARIKYEEALPWHLEDFDNQHTWVGNYEAALSETHAIFVLDNGKMRMIPAEKWYKFNAKSNFKALTIDEAEKFMAKRVKDPRWFMEKQQQLEQEKELETYAKQRKVYAGKQGTTAGKGAGLEAGEMDFEEDRFADDEEHDDLFNEDEDAKDAEKRIKEDQLKANVFNLKDEKEYDAEEMREKREREARRVLGKGVRKALKRRERNFDYSSGSDVNPYTDEESSDDSETERAKEEERKKAEEEKNQKEALSKGGNTPSGRPKHTDALKKASAAGSRKRLGSPNASDASGTDTSRKKAKNMHLPASQPPSRPISPSALQGKKRVRNIAGGAGSGSDGDTAAGSGAEMTEGGKIKKLKLNPPTSVSRGGTPQGSRGASPLPRLSGSRANSPDGPRGLRMSTPVSGNQTFPTAGEIHAAIPASGILSSDLLKVFRPRIGESKENHRRFIAIVKDVSVYGKEDRMLRPGPWKGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W6QLM3</accession>
    <name>W6QLM3_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S07g000081</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792021">
        <property type="protein sequence ID" value="CDM37733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QLM3"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM37733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="68" mass="7935" checksum="D238E9F9B11F32BC" modified="2014-04-16" version="1">MPTQQLMPMNPGNYIVLGKEERTTNCVMLQNMTPIPIMNATCVYPQARIEAEKLLLDRLRWPTSRRFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W6QLY7</accession>
    <name>W6QLY7_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 15">Squalene synthase</fullName>
            <shortName evidence="15">SQS</shortName>
            <shortName evidence="15">SS</shortName>
            <ecNumber evidence="4 15">2.5.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PROQFM164_S07g000176</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Catalyzes the condensation of 2 farnesyl pyrophosphate (FPP) moieties to form squalene.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>2 (2E,6E)-farnesyl diphosphate + NADH + H(+) = squalene + 2 diphosphate + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:32299"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15440"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:175763"/>
            <dbReference type="EC" id="2.5.1.21"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>2 (2E,6E)-farnesyl diphosphate + NADPH + H(+) = squalene + 2 diphosphate + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:32295"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15440"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:175763"/>
            <dbReference type="EC" id="2.5.1.21"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="15">Terpene metabolism; lanosterol biosynthesis; lanosterol from farnesyl diphosphate: step 1/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the phytoene/squalene synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.21" evidence="4 15"/>
    <dbReference type="EMBL" id="HG792021">
        <property type="protein sequence ID" value="CDM37828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QLY7"/>
    <dbReference type="STRING" id="1365484.W6QLY7"/>
    <dbReference type="OMA" id="CKSEESF"/>
    <dbReference type="OrthoDB" id="431150at2759"/>
    <dbReference type="UniPathway" id="UPA00767">
        <property type="reaction ID" value="UER00751"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055056">
        <property type="term" value="F:D-glucose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051996">
        <property type="term" value="F:squalene synthase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045338">
        <property type="term" value="P:farnesyl diphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00683">
        <property type="entry name" value="Trans_IPPS_HH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.600.10:FF:000003">
        <property type="entry name" value="Farnesyl-diphosphate farnesyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002060">
        <property type="entry name" value="Squ/phyt_synthse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006449">
        <property type="entry name" value="Squal_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019845">
        <property type="entry name" value="Squalene/phytoene_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044844">
        <property type="entry name" value="Trans_IPPS_euk-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033904">
        <property type="entry name" value="Trans_IPPS_HH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01559">
        <property type="entry name" value="squal_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11626">
        <property type="entry name" value="FARNESYL-DIPHOSPHATE FARNESYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11626:SF2">
        <property type="entry name" value="SQUALENE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00494">
        <property type="entry name" value="SQS_PSY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01018">
        <property type="entry name" value="Squalene/Phytoene_Synthase_Lik"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01044">
        <property type="entry name" value="SQUALEN_PHYTOEN_SYN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01045">
        <property type="entry name" value="SQUALEN_PHYTOEN_SYN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="14" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="10" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="13" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="6 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU368088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CDM37828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="429" mass="49307" checksum="9AFC9EACF17B90E9" modified="2014-04-16" version="1">MDLISDILYFVLRPNQLRTIIQWKLRRHPIHERNKQQESSTKICFDFLDQTGRSYSPVVKELHPELRLPVCVFYLILRGLDTIEDDTSIPLETKVPLLRNFKDVLDQDGWTFTGNRPEEKDRELLVQFDNVVAEFRQMKPVYQAIIKDTTDKMGNGMADFVEKAAVGDIAVNTIEEYDLYCWYVAGLVGEGLTRLFVEADLADANVINQSHLQKSMGLLLQKNNIIRDIREDNDDGRQFWPKKIWSKHVENFEDLFKPDNHELALNCSSEMVLDALRHTTDCLSYLAGLREQSVFRFCAIPQSMAMATLELCFRNPALFERNIKITKREAIGLVVESGAGLQGVCKVFCHFVHRIQQKNDPKDLNYLEIKTACEQIERFAESLKPQSIRLANSKINESWFTARRVLAIPVTSILVLGLAWLVQANLNAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W6QMH4</accession>
    <name>W6QMH4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S08g000129</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792022">
        <property type="protein sequence ID" value="CDM38078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QMH4"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM38078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="44" mass="5333" checksum="ACBF0D4C145E36E3" modified="2014-04-16" version="1">MTATARDVLWLVVAFLLAVKAINFLFWWAKREVKLYVNWSHRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W6QMM1</accession>
    <name>W6QMM1_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Translin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PROQFM164_S09g000044</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the translin family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792023">
        <property type="protein sequence ID" value="CDM38128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QMM1"/>
    <dbReference type="STRING" id="1365484.W6QMM1"/>
    <dbReference type="OMA" id="DTCMETC"/>
    <dbReference type="OrthoDB" id="31005at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14820">
        <property type="entry name" value="TRAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.190:FF:000008">
        <property type="entry name" value="Translin-associated factor TraX, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.190">
        <property type="entry name" value="Translin, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.200">
        <property type="entry name" value="Translin, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016069">
        <property type="entry name" value="Translin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002848">
        <property type="entry name" value="Translin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016068">
        <property type="entry name" value="Translin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036081">
        <property type="entry name" value="Translin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10741">
        <property type="entry name" value="TRANSLIN AND TRANSLIN ASSOCIATED PROTEIN X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01997">
        <property type="entry name" value="Translin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74784">
        <property type="entry name" value="Translin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDM38128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="280" mass="31608" checksum="426747044C8818B8" modified="2014-04-16" version="1">MGTKRDWEGQPLELHPKDTIMAEAESAPSILSIFENFRDELDEHHDRRERIIKKSRDITALSKKIIFALQRVRATNQPIPPKIAQENQTRFDQIQALFEAVVPEQLGINGWRYQRQISPGIQEFIEAISFDHYLRTETLITHAECSARVPPQILISEEDYLLGLFDLTGEMMRFAVLSLSSGNTTATQVTKNTTNESEKSPVAASQGGIVVDLRAMRAGFEALSVPQRHYMFRDMAKKLDVMQNSVEKVERAAYGIVVRGSERPSGWTPDLSGAMEVASY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W6QNH2</accession>
    <name>W6QNH2_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Probable transposable element</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S12g000072</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792026">
        <property type="protein sequence ID" value="CDM38463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QNH2"/>
    <dbReference type="STRING" id="1365484.W6QNH2"/>
    <dbReference type="OMA" id="RATSRVN"/>
    <dbReference type="OrthoDB" id="4207519at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05225">
        <property type="entry name" value="HTH_psq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="3">
        <location>
            <begin position="60"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM38463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="104" mass="11755" checksum="29E09E250E68D503" modified="2014-04-16" version="1">MPPIRSQSSTKSVEQEGRILLAIQALKNQEFTSISLAARTFNVPRSTLRHRLNGIQYRATSRVNSTKLTAIEEESLRKWIVSMDSRGSAPRPSMVREMADLLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W6QNL0</accession>
    <name>W6QNL0_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Carboxy-cis,cis-muconate cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S08g000031</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cycloisomerase 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792022">
        <property type="protein sequence ID" value="CDM37980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QNL0"/>
    <dbReference type="STRING" id="1365484.W6QNL0"/>
    <dbReference type="OMA" id="VQNYEYQ"/>
    <dbReference type="OrthoDB" id="1715191at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017057">
        <property type="term" value="F:6-phosphogluconolactonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000244">
        <property type="entry name" value="Carboxy-cis,cis-muconate cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050282">
        <property type="entry name" value="Cycloisomerase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019405">
        <property type="entry name" value="Lactonase_7-beta_prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30344">
        <property type="entry name" value="6-PHOSPHOGLUCONOLACTONASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30344:SF4">
        <property type="entry name" value="CYCLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G11580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10282">
        <property type="entry name" value="Lactonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75011">
        <property type="entry name" value="3-carboxy-cis,cis-mucoante lactonizing enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM37980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="360" mass="40508" checksum="A776484C574F1D41" modified="2014-04-16" version="1">MKHHLMVGTWTAPGRIYTVQFDDDALTLELVKNTEIPEAEPISWMTFSHDKKAIYGAAMKKWNSFAVNSPTEIIHQVSHPVAGHPLAPSSETNTRAIFVLAAHKPPYNVYGNPFYNYAGYGNVFSVKPDGSLDSNIQNYEYVPNTGIHGMVFDPTETYLYSADLTANKIWTHIKDPKTGELTLVDCLEAPDAGDHPRWVEMHPSGKYLYALMEAGNRLAVYVIDERTHKPVFTHITYPLLPSGLPPRNKYRGDVTFCTKGGEYLFATTRSNHFDVTGYITAFKLGSHGEIERQLFINPTSTSGGHSNAVSPCDFSDEWLALCDDQLGFVEMYRWRDEKLARVARVDIPEQGFGMNAIWYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W6QPB2</accession>
    <name>W6QPB2_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">ER transporter 6TM N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PROQFM164_S04g000825</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QPB2"/>
    <dbReference type="STRING" id="1365484.W6QPB2"/>
    <dbReference type="OMA" id="GTYHWFI"/>
    <dbReference type="OrthoDB" id="2274698at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018823">
        <property type="entry name" value="ArAE_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018820">
        <property type="entry name" value="BRE4-related_DUF2421"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049453">
        <property type="entry name" value="Memb_transporter_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37994">
        <property type="entry name" value="ARAE_2_N DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37994:SF3">
        <property type="entry name" value="ER TRANSPORTER 6TM N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10337">
        <property type="entry name" value="ArAE_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10334">
        <property type="entry name" value="BRE4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13515">
        <property type="entry name" value="FUSC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="61"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="174"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="203"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="628"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="657"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="680"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="706"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="732"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="770"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="domain" description="Putative ER transporter 6TM N-terminal" evidence="8">
        <location>
            <begin position="41"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="Integral membrane bound transporter" evidence="9">
        <location>
            <begin position="645"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2421" evidence="7">
        <location>
            <begin position="791"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="368"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF10334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDM35944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1010" mass="111570" checksum="4371DB332F2BB34F" modified="2014-04-16" version="1">MTDIELSQRDALEDESPLTSNGEGSSAPVKPAQAPKAGRKLPGWLDHFNARDMKVLFRCTLAAWVASLLIVITPSLSVIGTATFFATLVLFMVPPTGIVFIFLLGTLTVIIGMALGWAWGVITMKAAMAARPAAETQANLQSLGQAAYSQANSTGQAVAEVQKELIYNGWMLDARVTVVYYCLICLFIYLISRLRAKNPKLILLQILGIIIIDVTLTIGPMLPYFSGTVPKVLIEPAAIGIGLGLVSHFIFFPRSTSHVVLDGMEGLVRLLKGPVDVTENTLLKGQVLDMADLQRIKGQTIAAYRNLKPAMAFLPLDFSVGWWGADDIKSMKKPIRQALVSSLSLLEVHIARIGGEAKFKKLHQLTVDRDSDSDSQANGNEKKRPREVGMRQMMEGVNLVQAMRSPEHESMLSETVEVLRKSSKDILPACQEAVEIIAESINTANKRWFGRPSKERLNQLHERSQTVLQNLQALRTSFASETTDRLIQTHAEIFDEKGMLKALDKTSMPRVRGIMMGMVFEEQVLGVADGWERVLRQLVVLLKERQKIRLWLPKGLRYALNWVCRKNAVAPIPAADDPIVDPDVAETQSKAAQLHLRMSRGYRVHRGSSFGRAIIGTYHWFINPEGLYAMRMVAVTIALAIPAAIPHTAGFYYREKGIWALIMGQTTLVIYMADFTFSLICRAIGTVVGGVLGLVVWYIGSGHGKGNPYGLAAIMAVALTILMWARIFTSPAFLQATIMAGATYILVVGYSFEDTHIPTYGNPGWGYSVFWRRLVLVLIGSAAALIVQLFPRPPSASRHICKSLSNVIRSLSDHYALLLSCWGQGREEGLAAEKLALNLAETITALDGPIALLRFEFSSSPFDSDRLGQVKALCQELNQNIARLLYLSASLPEHLQTRLARQVGLLDHHNIGDIMAVLGVVEQSLKTGDPLPEMLPTPLLNRCHDYWKSHQTDIILSKELIRDENYRRFCVAISAYLKFLAAVDDLVLVMKGTLGESHIVSRDLLHEPNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W6QQA1</accession>
    <name>W6QQA1_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Developmental regulator flbA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">flbA</name>
        <name evidence="5" type="ORF">PROQFM164_S02g001858</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QQA1"/>
    <dbReference type="STRING" id="1365484.W6QQA1"/>
    <dbReference type="OMA" id="DPGMRYL"/>
    <dbReference type="OrthoDB" id="196547at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009968">
        <property type="term" value="P:negative regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04450">
        <property type="entry name" value="DEP_RGS7-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08708">
        <property type="entry name" value="RGS_FLBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000315">
        <property type="entry name" value="Developmental regulator FlbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000591">
        <property type="entry name" value="DEP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058855">
        <property type="entry name" value="RGS1/SST2-like_Fungal-DR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10845:SF192">
        <property type="entry name" value="DOUBLE HIT, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10845">
        <property type="entry name" value="REGULATOR OF G PROTEIN SIGNALING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00610">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25889">
        <property type="entry name" value="WHD_Fungal_DR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01301">
        <property type="entry name" value="RGSPROTEIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00049">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50186">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0734">Signal transduction inhibitor</keyword>
    <feature type="domain" description="DEP" evidence="4">
        <location>
            <begin position="342"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="RGS" evidence="3">
        <location>
            <begin position="462"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="46"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="613"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="46"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="81"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="114"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="620"/>
            <end position="631"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDM31707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="642" mass="71956" checksum="575EAE98B1F7C995" modified="2014-04-16" version="1">MPTQTGSHSREYSLPSVPDSDFGGIISRNRRSFAALAQKTSNALASLSGSTVRSSTSYGSLSRPHKLSATPVTPPFDSDTYEQLTGTSRPSSPALVDNPANSVLKRRLTLQRLPTPPHETRPSPPAPKMHQTSSRLLRMTEDERPFTKDFMDLFSTLMVSLKLDSHRVRFTRYDHTFTSEEAINNLGSLKFSQSNRMPDPKDPSRIVTTTTTTTFSMAKEMARSVCQRFVDARFIESVDGRELLIFPLKGALFQLTPKGINILQRFCQRNGITARHVMDVLESPRNTMQLVNLERDTDTDKLSHDRATIEVIFRRFAGQDGPNIKSSISTSDSDSLSDYTNGLVGVKVARERKLLDGKVYSNTFTGKASVDWLMDCSTTIERRETCLISELFLKYGLITMIQDDKQFPDVGTNAHFQPSKYAIYGITERGQRVCGWIAREKTREVAPTYDSRGMPRDSNNARLTHILQDPALRLLFREFLRYSLCEENLSFYLDVSEFTTNYHKAEKMGTFNKVDSVRETLAAAYGLYNAFLAPGSPCELNIDHALRNSLASRMTKAVGDDESMFKSLQEVVHLFELAQTSVFKLMSSDSVPKFLRDPKYSVVLQEHDVDIIGGSRSYSPTPPAPPAPPAIPERSMSRSARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W6QRE0</accession>
    <name>W6QRE0_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Coatomer beta' subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PROQFM164_S02g002263</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QRE0"/>
    <dbReference type="STRING" id="1365484.W6QRE0"/>
    <dbReference type="OMA" id="ATYQVVH"/>
    <dbReference type="OrthoDB" id="431715at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045943">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000633">
        <property type="entry name" value="Small nucleolar ribonucleoprotein complex subunit Utp15, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000867">
        <property type="entry name" value="Small nucleolar ribonucleoprotein complex subunit Utp15, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018983">
        <property type="entry name" value="U3_snoRNA-assocProt_15_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19924:SF26">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 15 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19924">
        <property type="entry name" value="UTP15 U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 15 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09384">
        <property type="entry name" value="UTP15_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="134"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="177"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="264"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 15 C-terminal" evidence="7">
        <location>
            <begin position="394"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF09384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM32112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="542" mass="60225" checksum="B3FB4AEFEBEFFA10" modified="2014-04-16" version="1">MAAPVLPLQQVKLASLPSTQLTPEQQYWRTFKNPLLIPSPANGPVNLITQPSVPSSAAAFPSLTQPPDVFTVTTGARVQIYSIRTRKLLRTLTRFDDTVRGTDVRPDGRVLVAGDDTGSVQVFDVKSRAILKTWKDHKLPVWVTKFSPSDPTAVLTASDDRTVRLWDLPSQTSARTFVGHTDYVRSGAFMPGSMASSGLVVSGSYDRTVRLWDPRVGNRAAMTFKMGAPIETILPMPAGTTVLAAADNKIAVLDIVAGKPLHMIQSHQKTVTALALASNGERLLSGALDGHMKVFETTGWNPVSGSKYPSPILSLRAITSGTEYEDKHIAVGMQSGLLSIKTRLSGQQKIKERERRKEMAALLEGKLEEHDREVAKKKKTRGSGWEKRLRGRDFIGEGVEIVIEGQDRKKRKREQPWENDLRKARYSVALDQVLSSADKTSQLTLLTALRHRSALRASLKDRDEVTLQPVLQWVYKNIREPRLVDLSVEVAMNLLDIYSGNLGQSVQVDKMVERLHRRVRDEVEMAQQAWQTKGMLDMLKAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W6QRP3</accession>
    <name>W6QRP3_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S05g000562</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QRP3"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM36729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="95" mass="10029" checksum="DB1E97991DCB834B" modified="2014-04-16" version="1">MVGVVVSSSSCLHGQAAHRAFPSSLSAFHFAYRAFPSSLASSHFATCFFFLSTIMPATTEDSTMLSIATATTEDFTMPAPDLATTTEDSTMPAIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W6QST9</accession>
    <name>W6QST9_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein BTN</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">btn1</name>
        <name evidence="10" type="ORF">PROQFM164_S06g000130</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Vacuole membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the battenin family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792020">
        <property type="protein sequence ID" value="CDM37169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QST9"/>
    <dbReference type="STRING" id="1365484.W6QST9"/>
    <dbReference type="OMA" id="WLCNWQV"/>
    <dbReference type="OrthoDB" id="5965864at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051453">
        <property type="term" value="P:regulation of intracellular pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003492">
        <property type="entry name" value="Battenin_disease_Cln3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018460">
        <property type="entry name" value="Battenin_disease_Cln3_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10981">
        <property type="entry name" value="BATTENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10981:SF0">
        <property type="entry name" value="BATTENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02487">
        <property type="entry name" value="CLN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015974">
        <property type="entry name" value="CLN3_BTN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01315">
        <property type="entry name" value="BATTENIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="8" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="161"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="190"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="289"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="327"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="357"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="383"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="225"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="238"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDM37169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="462" mass="49905" checksum="D447BEDD59D7AD1F" modified="2014-04-16" version="1">MPLPVSDEDAATLPPQEQSSPFWKRLSARLSGAFSGADPRVCVAFWLFGLINNVLYVIILSAAVDLVGPDVPKGVVLLADVIPSFATKLVAPYFIHLVPYSIRVLVFAFLSTVGMLVVAMSPGYTDGGTISSKIAGIILASLSCGAGELSFVGLTHFYGPFSLAAWGSGTGAAGLVGAGAYAVATSALGFSVHVTLLVSACLPAIMGLSFFVVLPRSPLRSAESDADSYRAVEGGGPVEEDEVDDGAGGEDEGLLGVSHNSPAHKSIHVNQGGSWQDQTRMNLRRIKGLFIPFMIPMLLVYIAEYVINQGVAPTLLFPLRESPFDHFRSFYPTYNAIYQVGVFISRSSTPFFRIHKLYLPSLLQVVNLVLLTLHAMFDFIPTVWLVFIIVFWEGLLGGVVYVNTFAEIAERVPKEDREFSLGATTVSDSGGICIAGFLSMGWEVWLCSWQVSHGRDYCRRKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W6QV98</accession>
    <name>W6QV98_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S08g000110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792022">
        <property type="protein sequence ID" value="CDM38059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QV98"/>
    <dbReference type="OrthoDB" id="10469527at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM38059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="69" mass="7617" checksum="3DD953BFC6B17524" modified="2014-04-16" version="1">MRVAKCNIWHRQAMSGSFWKAVETSSDDMDVVAASGTPRSRVYELASRPSSQSFSSLLTQLLSILTPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W6QVA4</accession>
    <name>W6QVA4_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phenylalanine--tRNA ligase alpha subunit</fullName>
            <ecNumber evidence="5">6.1.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Phenylalanyl-tRNA synthetase alpha subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">FRS2</name>
        <name evidence="18" type="ORF">PROQFM164_S03g000216</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>tRNA(Phe) + L-phenylalanine + ATP = L-phenylalanyl-tRNA(Phe) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19413"/>
            <dbReference type="Rhea" id="RHEA-COMP:9668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78531"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="5"/>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QVA4"/>
    <dbReference type="STRING" id="1365484.W6QVA4"/>
    <dbReference type="OMA" id="QIEGWVM"/>
    <dbReference type="OrthoDB" id="238316at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009328">
        <property type="term" value="C:phenylalanine-tRNA ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00496">
        <property type="entry name" value="PheRS_alpha_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2330:FF:000002">
        <property type="entry name" value="Phenylalanyl-tRNA synthetase alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000028">
        <property type="entry name" value="Phenylalanyl-tRNA synthetase alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004529">
        <property type="entry name" value="Phe-tRNA-synth_IIc_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002319">
        <property type="entry name" value="Phenylalanyl-tRNA_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040725">
        <property type="entry name" value="PheRS_DBD3"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00468">
        <property type="entry name" value="pheS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003210">
        <property type="entry name" value="PRK04172.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538:SF40">
        <property type="entry name" value="PHENYLALANINE--TRNA LIGASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538">
        <property type="entry name" value="PHENYLALANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18553">
        <property type="entry name" value="PheRS_DBD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01409">
        <property type="entry name" value="tRNA-synt_2d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 18" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0436">Ligase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="17">
        <location>
            <begin position="223"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00015409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00030612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CDM33492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="512" mass="57829" checksum="FCAA1908A9964125" modified="2014-04-16" version="1">MASDLTNQILDALSASDAPILSSEAFPSTPSLNVKSALDRLDSRQMVEYETLDKEIVTLTAEGQEIATNGSHEAKVFAVVLAALDGLKISDLPGIVGKENAKVGQGNAFKRGWIKKDKDLLRASTDSIVDETQQQLLEVQKTKNLDDKKALADLKRRKLVGLAKEISFKFTKGPKYAREFVKEQTDLTPEMIASGSWKTAHLKPYNFNAKGAPTPCGTLHPLNKVRQEFRNIFFEMGFEEMPTNRFVETGFWNFDALFVPQQHPARDLQDTFYISDPAVADAPREDPPNDPHRPAQLKSEKPLDYKKYWDNVREVHEHGKFGSIGYRYPWSADESLRLVLRTHTTSISTYMLHKLAANPRPARFFSIDRVFRNESVDATHLAEFHQVEGVIADFGLTLGGLIGFMEVFFAKMGIHKLRFKPAYNPYTEPSMEIFGYHDGLGKWVEIGNSGMFRPEMLESMGLPKDLRVYGWGLSLERPTMIKYAVSNIRELLGHKVDLDFIQTNPAVRLEKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W6QVB3</accession>
    <name>W6QVB3_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PROQFM164_S03g000226</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QVB3"/>
    <dbReference type="OMA" id="RGYYMGT"/>
    <dbReference type="OrthoDB" id="19092at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="279"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="87"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="241"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="345"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="364"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="413"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDM33502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="437" mass="46863" checksum="B4C245F15216A05B" modified="2014-04-16" version="1">MSTMMSSPTSSQNIISTNNLSVLPPILTDGTVKRSSTHPKDRLSTYSNVSFASQNRSRPGSHVFPIFHTSLPYALVRDFAYPSTHPLHYGPPPPRASGVSTPASEHRRLSDPSPSWDISRGWSTGQSGIEPQITYVHQQLPAMSFGDGPPYSEDEDLHSPVVTSRHRKKTSDINGLVDERVMSGTGQAVNSDRGMLVGINPDGSETYYVNDGDTSDDGPGGEYVTYPANEGRYSTMGYSAPAGQQGYEHDPGFESEDENPGDNRYSRDYQFAVGCPDEEMHGKAVALFDFTREHENELPLTEGQVIYVSYRHGQGWLVAEDPKTGENGLVPEEFVRLLRDIEGGLTSLNGEPNPDVTGAADVSLDSTESEQISTPTQVEQASFAVSAQSGNKTTDDSSLAAVSTEGADASQSATNTGTPTGKAAGGADKRSSTLSKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W6QWA3</accession>
    <name>W6QWA3_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Putative gamma-glutamylcyclotransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PROQFM164_S03g000496</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the gamma-glutamylcyclotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QWA3"/>
    <dbReference type="OMA" id="FKLWGPY"/>
    <dbReference type="OrthoDB" id="3262926at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06661">
        <property type="entry name" value="GGCT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.10">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045038">
        <property type="entry name" value="AIG2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009288">
        <property type="entry name" value="AIG2-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013024">
        <property type="entry name" value="GGCT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036568">
        <property type="entry name" value="GGCT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31544">
        <property type="entry name" value="AIG2-LIKE PROTEIN D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31544:SF4">
        <property type="entry name" value="GAMMA-GLUTAMYLCYCLOTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06094">
        <property type="entry name" value="GGACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110857">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Gamma-glutamylcyclotransferase AIG2-like" evidence="5">
        <location>
            <begin position="28"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00030602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF06094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDM33772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="156" mass="17561" checksum="AB0BEE1F03A8534C" modified="2014-04-16" version="1">MRSTSPSHFFQPQVRRSQNQGPAPTGPYFFYGSLHDQNLLIELLDLSHAPHLRPAYIQGYKRKLWGHYPALLSGDPMDTVTGAVYEVLRVDDAKKLAAYEGPSYTTVACSIRYADGESPIQAEGYAFLFVGNTRDLSEGSFDFKLWLERRALGRKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W6QYR7</accession>
    <name>W6QYR7_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S03</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S03g001417</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QYR7"/>
    <dbReference type="STRING" id="1365484.W6QYR7"/>
    <dbReference type="OrthoDB" id="4869816at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM34692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="56" mass="6452" checksum="6F96B167D4056F41" modified="2014-04-16" version="1">MGSMATDLPWVYVLDVSFDHGSQVEEGEYPGYFRVALESLLMDLYPLLEIMPFHEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W6R0P9</accession>
    <name>W6R0P9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S04</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S04g000293</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6R0P9"/>
    <dbReference type="STRING" id="1365484.W6R0P9"/>
    <dbReference type="OMA" id="MIHDRIT"/>
    <dbReference type="OrthoDB" id="2104739at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13391">
        <property type="entry name" value="HNH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HNH nuclease" evidence="1">
        <location>
            <begin position="132"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM35412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="325" mass="36730" checksum="43A3450924AF314F" modified="2014-04-16" version="1">MSTELADDWSTLAAKAQARVSQYKPQQHQQHANFLPVSLNAFITWLPEGGRECLARDIIGSKSDNELYDIFSNLLTGPATPMRARSKPPSVSPSPHAKREAHVEAVAATLTQPEKRTSQFKELCLKRDDNRCVITGELDIEYWEELNRPEEPYFGRTEGAHIIPFCYASWESAEVLYRCFPLVRQVQEGISTETINDTSNGMTLRANIHDEFRRFTIALKPTNVYEVKTFPRFPKWDISALPTSSTIHLTQADDAQDVALPKAALLDCHYRLSEILNASGMGHVIDRYLRDWEDIKCEAPKTLDEAGRTNVNAFLQAGLWEHALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W6R271</accession>
    <name>W6R271_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Genomic scaffold, ProqFM164S04</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PROQFM164_S04g000818</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ATG33 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6R271"/>
    <dbReference type="STRING" id="1365484.W6R271"/>
    <dbReference type="OMA" id="WCLSSPR"/>
    <dbReference type="OrthoDB" id="5336366at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051668">
        <property type="entry name" value="ATG33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37278">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 33-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37278:SF1">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 33-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="164"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM35937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="185" mass="20836" checksum="2C5F278807AC3217" modified="2014-04-16" version="1">MACPISVSKFVGTVSLGLLTGLSYSTSAITIPALQLLPTATTAARSLNEVKRLTRRYALRLSFLTNTCFCFAWCLSSPRRRHPYMIWLCAFSTIGAHGVDFWFHRHLGFKNWVSAVIRDVSHFSLIRDSNTSKDEDLVVVEAEDDVNGETVQREMDRERRLNQARTWLSGIALSIGIVGLWGDKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W6R4N0</accession>
    <name>W6R4N0_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S05g000590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6R4N0"/>
    <dbReference type="STRING" id="1365484.W6R4N0"/>
    <dbReference type="OMA" id="FGIRGIW"/>
    <dbReference type="OrthoDB" id="94039at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="107"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM36757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="442" mass="49827" checksum="A618C5245F79157F" modified="2014-04-16" version="1">MSSPFRIIEHVVPTQHIREYPGATANDQEEPLYLAVKQYIPLDNPNPQPGDITILGAHANGFPKELYEPLWEEIYARSKQNGMRIRGIWMADVAQEGQSSVINEDSLGNDPSWFDHPRDLLHLINVKRAEMPRPIVGIGHSMGGAHLAQLCLMHPRLIHTLVLLDPVIQRQTTQLDNLSLQINKRVIAKTTQLSTHRRDLWPSRQAAAESFRRSPFYQTWDPRVLSRWIEYGLRDLPTAIHPLDPKTPINKTTGPPVTLRTTLHQEVFTFSRPNYTNIPNSTKPVNRVTHPDLDATHAHSYPFYRPEPARIFAQIPFLRPSVLYIFAGKSDMCGPDMRADKLANTGTGLGGSGGVAAGRVSEVFLEDFGHLLAQEAVNECADAAVCWLAPEIRRWRAEEESFRAAWSRKSKIEKVTVDAEWLENVPAPARRPKAVQNGESKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W6R4N4</accession>
    <name>W6R4N4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Prefoldin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S05g000595</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prefoldin subunit beta family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6R4N4"/>
    <dbReference type="STRING" id="1365484.W6R4N4"/>
    <dbReference type="OMA" id="REMIQQK"/>
    <dbReference type="OrthoDB" id="2015447at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23164">
        <property type="entry name" value="Prefoldin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002777">
        <property type="entry name" value="PFD_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20903:SF0">
        <property type="entry name" value="PREFOLDIN SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20903">
        <property type="entry name" value="PREFOLDIN SUBUNIT 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01920">
        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM36762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="120" mass="13600" checksum="F547E951AE845551" modified="2014-04-16" version="1">MSIPNEALQKLFQEIETRAISSQQQISITKAHMTAKQRDIRMLQLTSKELSELPSDTNVYEGVGKMFVNVPVGIVNKRLVRESGEATAEISNLEKKLQYHETTNQKSRENLEQILKSGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W6R868</accession>
    <name>W6R868_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S08g000113</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792022">
        <property type="protein sequence ID" value="CDM38062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6R868"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM38062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="57" mass="6298" checksum="D7B54AA36EA49081" modified="2014-04-16" version="1">MEFGVSLINVSSLHELLTNLPELLAPLYSSCMPNSIKIESLDIIGVRISVRTTRLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W6R8C2</accession>
    <name>W6R8C2_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Haemerythrin/HHE cation-binding motif</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S09g000033</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792023">
        <property type="protein sequence ID" value="CDM38117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6R8C2"/>
    <dbReference type="STRING" id="1365484.W6R8C2"/>
    <dbReference type="OMA" id="CSQLDFH"/>
    <dbReference type="OrthoDB" id="10044044at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12108">
        <property type="entry name" value="Hr-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.520">
        <property type="entry name" value="nmb1532 protein domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053206">
        <property type="entry name" value="Dimeric_xanthone_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012312">
        <property type="entry name" value="Hemerythrin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38048">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38048:SF1">
        <property type="entry name" value="HEMERYTHRIN-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01814">
        <property type="entry name" value="Hemerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hemerythrin-like" evidence="1">
        <location>
            <begin position="25"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM38117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="172" mass="20268" checksum="766CD1CAE89F3D6F" modified="2014-04-16" version="1">MASSSGDSGDSPLSASDFRTYNRMSEQMEGFHSHFRLTWNQLWEACENSRKRGLSARQMIMMGLQFCSQLDFHHSIEEQHIFPVLAKKMPEFRKELELLSQHRQIHAGLEKLEKYLEQCRSGEEDMRREEVKRLMEGFGKVLWTHLDQEVQTLGAANMRKFWSLAEMRQLPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W6R9D2</accession>
    <name>W6R9D2_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S12g000076</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792026">
        <property type="protein sequence ID" value="CDM38467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6R9D2"/>
    <dbReference type="OrthoDB" id="4411012at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM38467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="132" mass="15550" checksum="43ECE48FF1DFC57A" modified="2014-04-16" version="1">MRDSYLIFSRSTPAPVYSPVLIGHNLSAYRPRKSSNRLYFTLITGDYSGDLRYKNERFFTALQHGWKYNQTRYKVHFPSSITLNIYDIIQCHETVELPLEKVFTNTKQGVYSEYCYYNNPAIKELRSSDIVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W6PQW7</accession>
    <name>W6PQW7_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Taurine catabolism dioxygenase TauD/TfdA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PROQFM164_S01g000402</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TfdA dioxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PQW7"/>
    <dbReference type="STRING" id="1365484.W6PQW7"/>
    <dbReference type="OMA" id="EFVIVYD"/>
    <dbReference type="OrthoDB" id="10257314at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051323">
        <property type="entry name" value="AtsK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT SULFONATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468:SF1">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT SULFONATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="7">
        <location>
            <begin position="56"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM26593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="359" mass="40923" checksum="66CBB5C32D378304" modified="2014-04-16" version="1">MVSETVEEKRPLYPDYLPFYDPLEKVEMVGPFEHDDPGHRADPSFPNLLKKATNVVQLSPHCGTELKGVQISELSTEGLDELALMVADRGCLVFRDQTFTDLGFEEQKRIASHFGPLHKHGWMPHPKNGPEEFVIVYDSKDDLRIRKSWARKSPIQFHVDQSPETQPPGATFFCMLESPPGAGGDTIISNMTRAYERLSPSFRKRLEGLKAVHTTANPIMREIRDNGPDSVLRRPITRTIHPVVIIHPVTKKKALFVNSSYTQSIVGWDEEESDYMLKFLFDHINRGHDFCCRVRYEPGTVVIWDQRVTQHSQTLDYQAGSRRHAFRLTPLANVPIPSLIEEDDGECAKDEGRMMLNLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2024-10-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>W6PQZ3</accession>
    <name>W6PQZ3_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S01g000089</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PQZ3"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM26280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="80" mass="8907" checksum="438787139CA5A93A" modified="2014-04-16" version="1">MRVGSPIEGPNRAIHHVDASEGLEMLEDSICGLRITEKELQTEAAEFGALLKDTTNRFAALSEMIESPSKRVLSVSRFYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W6PR97</accession>
    <name>W6PR97_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g000537</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PR97"/>
    <dbReference type="STRING" id="1365484.W6PR97"/>
    <dbReference type="OMA" id="YKFPMWV"/>
    <dbReference type="OrthoDB" id="5593235at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM26728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="418" mass="47997" checksum="7CA3D93CB8062FF0" modified="2014-04-16" version="1">MERELLTMSRTQNLRDIESNNEKKHSHWRDWAFVLLWGATGYACIILMVLLYSNPKLIPFDICSLLFRKEISPFFAFSQGTGHYSKPQGFKIVALVPFHYHGRTEILDCYLQKNLVHNNGFLDQVIFVPQTDDAVDMEWLYSIVNQTPEYAISSRYHEIEWEVAKNNVMYIRIDGDIVFLEDNAIPTIVKTKLDNPSTLMVSANVINEAALASLHSHPGTALPYLPELYDVEQPSRSKLQLKHDWRASNLPNWQGPPSFKISKDFDPPFEGHRWLLPRDAGSDRDPIARSVYTDTGPTLHDWTVGAQQHYSFLHHLEHNDLGRYKFPMWVDPTEPTSDNFGCFWGNDAVDVHRIFRNNQNGSSHNWHMSDGSRPHIIIDGKGLVSHYSARQGAAGLDATDLITRYRAYAQEKVCLQTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2024-10-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W6PRM9</accession>
    <name>W6PRM9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g000334</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PRM9"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM26525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="72" mass="8017" checksum="50F8AFE47BAE6DC5" modified="2014-04-16" version="1">MTNPLLNLYRQPLLRPKQQGPRQGPRNRNPKGTAAEVVCGEVRGCNNAINKPGGSWEQARLTIEETTAWDCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W6PSG6</accession>
    <name>W6PSG6_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Crotonase, core</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g000977</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PSG6"/>
    <dbReference type="STRING" id="1365484.W6PSG6"/>
    <dbReference type="OMA" id="PKTDSWH"/>
    <dbReference type="OrthoDB" id="2018133at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006108">
        <property type="entry name" value="PRK08259.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43802">
        <property type="entry name" value="ENOYL-COA HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43802:SF1">
        <property type="entry name" value="IP11341P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM27168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="273" mass="28900" checksum="5A019ED2652B076E" modified="2014-04-16" version="1">MAEPGRVTTDTSSYPGISVVAINRPDRKNAVDPLTAKALYEAILLFENDAKQKVCVLTGAGGSFCAGADLHMVAQANNDTPSDNLQPVNGRNLGPMGPSRLIIKKPVICAVSGYAVAGGLELSLLADMRVVEEDAVFGVFCRRWGVPLIDGGTVRLQAIVGLGRALDMILTGRAVSAQEALTMGLASRVVPKGESLKEAIGIARQLITFPELCLNTDRHSCYYSAYEASSFQDAMTQEFNAGSKVISQEAIAGAAKFSKGLGRHGSFKDHSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W6PSR3</accession>
    <name>W6PSR3_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Phox homologous domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PROQFM164_S01g000719</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sorting nexin family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PSR3"/>
    <dbReference type="STRING" id="1365484.W6PSR3"/>
    <dbReference type="OMA" id="INGWIIH"/>
    <dbReference type="OrthoDB" id="41200at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06093">
        <property type="entry name" value="PX_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003114">
        <property type="entry name" value="Phox_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013937">
        <property type="entry name" value="Sorting_nexin_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22775:SF47">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 122 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22775">
        <property type="entry name" value="SORTING NEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08628">
        <property type="entry name" value="Nexin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02194">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51207">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="54"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="PXA" evidence="4">
        <location>
            <begin position="156"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="336"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="385"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="668"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="345"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="689"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="710"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="721"/>
            <end position="734"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDM26910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="923" mass="101526" checksum="B1D4D9C0ADF917C0" modified="2014-04-16" version="1">MSRLSDDDSEVISAPSDKDHNTPTTKDPILNTAISKELINAILNFLSTSTNETLLGVFALLALVTYIVLGRIGLLLIGVAVGVVLHASWEGSDNEHGEEASHVQKPNRRRELALEVSNRLLDWPRRAGASDIQGDDGSINTLEDMSSADLEYATFQPATAVALRTLTDAVIQDYVKYWILTHFITSVSSHLSRKRTEDTFLQFLTNSSSIVIVFLNELAAAFTAASSSPTEAQKTVDQYLEQFPDSSLANVLSAEQQKKKLSMIADDILSNFLDAKTYNYPAVRDFLREVFAGVILGSTVTSLARPEFINEWIIYLLQGGESEIMHAIDAGVEGARNQGVSAPRSSEHPKADSVKATQRDSMHVARATEEEAVLEVKRLSAMIVSHDTQNSESERTRQNEQFDENYPLNTDLASDTTDENENHEDQGPIPNTQSLASPKSFEDSSVPPLILHGAQVLVDDDGARDEKGQIKSRPVWDYLLQVEPASTRSTGWMVFRKYSDFQSLHEILGTVSRLNQISSFSERHPILPTWKGKTRLALARDLGWYLQDAMKHESLADTDRMRRFLQKDAGASTQPSCNNKPGFSFPSQIAFEHMGKGMLGALTNAPRGVAGGGKAVFEGMTGVFGGTANGKKPAVGADQIQPKVDDSSRAIRSQTRFSFADRTDVSNENVDSPMVFPSDPLEIQGGEISKSSSVGSTRESFESERGAWTTEISPSKTSLDISDHTAELDVRATETIDQTSSHRRSDTGQSIDKPRNQGNPITADETKIAVELIFAVINELYTLSSAWNIRRTLLNAAKSYILRPGSPTLETIRTLLQDSMIEGHTSDDALGYYLVKLRENALPTEEELKAWPSPPSEEEKIRLRDTARKLFVQRGIPQALTSVMGAAASREALEKIFDSLQVESVARGFVFSILLQGLRVLTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W6PT21</accession>
    <name>W6PT21_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g000834</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OMA" id="CENLTFF"/>
    <dbReference type="OrthoDB" id="4361124at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM27025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="249" mass="28477" checksum="700B3B4ACD474806" modified="2014-04-16" version="1">MSLKSQYEEDNYVFFSGRLSFQHSESLEYLDLDIYGGADHGLDLNPFDVLKEIIITPHSILGDPDEKMIMARSLQRLTIRYEEGTRLPLNSILEELEKKNLPNMRSVICQIPDNICEGTTSSEICVEAEAFKPNSKELGVELSTELVPYPLTMPKYDTCPCENLTFFHQFPSHPRVKSRPPNEHTTNTTDAGHSNPHPAGVISFDDYDPYYDDPYEGNHPSLYDMSPPTPPRMPTFTDYDDYCDWAYDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W6PT79</accession>
    <name>W6PT79_PENRF</name>
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        <submittedName>
            <fullName evidence="6">UbiA prenyltransferase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PROQFM164_S01g001209</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PT79"/>
    <dbReference type="STRING" id="1365484.W6PT79"/>
    <dbReference type="OMA" id="CWIAITY"/>
    <dbReference type="OrthoDB" id="434972at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13965">
        <property type="entry name" value="PT_UbiA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="215"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDM27398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="246" mass="27295" checksum="E3BBE94A17FED0C2" modified="2014-04-16" version="1">MGRCAMIVQGALTSLWYHSYTLWLFLFSDFKTIVIPKTIFGITNAWAASKYDPHVAGALPPPQNISDSPKSIGRAVATFYKNPVIRNIINGLGFTCFASGAMEVALGGSFLPLHPLGWSGRWLLVVIGIIFSTVQLQDMSDQAGDAKRGRRTVPLVWGDTAARWTIAIPMLGWGIWSPMFWEVSSLCFILSMALASLVALRALLIRSVLGDKQTFRLWNCWIVVVYMLPMFSEREPLQSRLSSHVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W6PTG3</accession>
    <name>W6PTG3_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Rho GTPase activation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S01g000979</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PTG3"/>
    <dbReference type="STRING" id="1365484.W6PTG3"/>
    <dbReference type="OMA" id="REHRRSW"/>
    <dbReference type="OrthoDB" id="3196451at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060237">
        <property type="term" value="P:regulation of fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04396">
        <property type="entry name" value="RhoGAP_fSAC7_BAG7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051025">
        <property type="entry name" value="RhoGAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15228:SF25">
        <property type="entry name" value="F-BAR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15228">
        <property type="entry name" value="SPERMATHECAL PHYSIOLOGY VARIANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="3">
        <location>
            <begin position="75"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="303"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="487"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="311"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="321"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="331"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="346"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="387"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="397"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="447"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="492"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="544"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="565"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="624"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="684"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="741"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="759"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="784"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="830"/>
            <end position="840"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM27170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="863" mass="94193" checksum="4DB7395710929021" modified="2014-04-16" version="1">MVTVGKSHPGADPVHPLPTSPDPVSANSPPSKRDLASWWKQFKRSTRKDELKEEAPRGIFGIALNVSIKYANVAISLTNDHGESFIYGYVPIVVAKCGVFLKEKATDVEGIFRLNGSAKRIKDLQEVFDSPERYGKGLDWSGYTVHDAANVLRRYLNQLPEPIVPLEFYERFREPLRIYQRQVLEGKNTTDADKFDHAKAVSTYQNLIIELPPLNKQLLLYILDLLAVFASKSDQNRMPSANLSAIFQPGMLSHPQHDMSPEEYKLSQDVLIFLIENQDHFLFGMSGTAADEQTVKEVEAGIARPHPTVRRSVSNASANTESHRKLDSIRRNVSVSSRNSRHSNNTQSPVTPTSITGGGGGGVHRSNTLPSKMGPVLTSARYARANDTGSNNPSGLSVSHQSSRSNSRTPSVREEPEQPEPIPESVSHPVPRPVPEQTSEQRPEQRIPSQSTASLTPGNVYVHTSTHGPLPLATAERLVINETTRPHDNLNTVVSPPVTLPPQVVTPSRERKLSSFFTKSPPPDYELREHRQPNRLKKKRIPGSASMSAQSSTNSLHASTPAHSADLEPKHENRSVEAAVGDTTPKPPNAATLGNRENPFDSNSALVEGTLQHHTDHSLRPNKSRTPSMNSRSSFTDQSDMDQPDDVTRHENRRSWRFHRSPKRTSEQLGLGFASPPLGATNPRAEQSTTSIGSGQYQSTDLSNHPLSLDAGVQGTSSAGSEPEKKSLFGKFKAKVAQVRDGVKDDRERTKSPTRSENEPSLTNRPLSPNATESTNGNHASVEVPREQPKEEHIRSPVSPLPGAGLPPSIPEEPHSPAASASVPVIEQKGSAQLPATESVSAPEPPLSNEILEEIAGPSTSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W6PTM1</accession>
    <name>W6PTM1_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PROQFM164_S01g001034</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PTM1"/>
    <dbReference type="STRING" id="1365484.W6PTM1"/>
    <dbReference type="OMA" id="ACMAIFY"/>
    <dbReference type="OrthoDB" id="2988756at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF2">
        <property type="entry name" value="SRPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="40"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="130"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="180"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="215"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="247"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="21"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="334"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM27225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="377" mass="41886" checksum="B4C4912317A17504" modified="2014-04-16" version="1">MDGFNTEAFTLLGVAITVIGLRTTARWIMVGPKGFQADDYLMLVACVVYGLETGAAYMVGAWFMGLANNAMTDEERRELSHNSEEYRLRVGGSKVQVAGWSLYTLLLWLLKTCMAIFYSRLTAGLVNMRIRIHIAHVLIAITYIATVCSILFGCHPMDKNWQIYPNPGNYCQPAVSKIDIYVTVVLNVATDLYLISIPAPMLVKARLKWREKLELLVLFSGGLFVMMAGILRCVLILTAGANGAQQAGSWACRETFVAVIIGNIPMIYPLIRRFTKRAGLYITSRNESESYPGYHLSDADTGGGYSKRKKFRHPLSIPGDTQWNTISDEQMILPTSRQQPPTCTAGDGDWKSQSQSSQGGIKVVHETIVHRSEKSQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W6PUL9</accession>
    <name>W6PUL9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S01g001396</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PUL9"/>
    <dbReference type="OrthoDB" id="4355239at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM27585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="116" mass="13226" checksum="3F8E97D58C4388E8" modified="2014-04-16" version="1">MVNQKPAPIPAQILYGPAKIALEAMLFLRIASPSLLEWRPSENLSQDAEMLLDACKTLRSRGSQEPYLENDLHLHGLIDFLSWPYDSEVKGILQDRYRSIMCGMDSSNFDFLLVRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W6PW43</accession>
    <name>W6PW43_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g001817</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PW43"/>
    <dbReference type="STRING" id="1365484.W6PW43"/>
    <dbReference type="OMA" id="AWHNDAP"/>
    <dbReference type="OrthoDB" id="426718at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021838">
        <property type="entry name" value="DUF3431"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37490:SF3">
        <property type="entry name" value="DUF3431 DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37490">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11913">
        <property type="entry name" value="DUF3431"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM28006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="380" mass="42332" checksum="32ABF50CCE5605B1" modified="2014-04-16" version="1">MGRKVQRSLIQLIFFLCILFFILFLNRPQSTKDKLFAWTKVRYQTTSSIIPEARGVCPGLAESTKPALIVSHVSSDGDPSWLEPLRTQYHVCMYQVDAPADKTSKLLQVPANRGHEAMAYLTFLIDNYADIPSAGAVFVHGSRWAWHNDIPDYDNAALLRSLDIHAALKAGYSNLRCDWSAGTCPSSVPAQGSLETRLSSAVSPWSARSASDLALPEALGQIFGGDADARVEEITSAVHLYLGRQDAVRAQCCAQFVVSRERIWQHAQSEYIALRQWLLDGSDDGVSRNVYRESRAAPGDDRIAGRIVSYIWHILFADHAGERGIDLDRLNRDSCPSAAECYCRLYGKCDLKCRGPGSCKGQYSVPKDYRLPEDWEKTHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W6PWB9</accession>
    <name>W6PWB9_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Pyruvate decarboxylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PROQFM164_S01g002354</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM164</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TPP enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PWB9"/>
    <dbReference type="STRING" id="1365484.W6PWB9"/>
    <dbReference type="OMA" id="AIRGCIM"/>
    <dbReference type="OrthoDB" id="4258301at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004737">
        <property type="term" value="F:pyruvate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000949">
        <property type="term" value="P:aromatic amino acid family catabolic process to alcohol via Ehrlich pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07038">
        <property type="entry name" value="TPP_PYR_PDC_IPDC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012110">
        <property type="entry name" value="PDC/IPDC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047213">
        <property type="entry name" value="TPP_PYR_PDC_IPDC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43452">
        <property type="entry name" value="PYRUVATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43452:SF11">
        <property type="entry name" value="PYRUVATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Thiamine pyrophosphate enzyme N-terminal TPP-binding" evidence="9">
        <location>
            <begin position="6"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme central" evidence="8">
        <location>
            <begin position="211"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDM28543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="597" mass="65977" checksum="3A98C2F3621AF010" modified="2014-04-16" version="1">MSDDITLAGYLFERLHQVGLHAVHGVPGNHNIGILREATDAALGCVTHRSDLSVGLVADGYARVKGIAAVISSFENMSPSVPTAIAASYRDRIPVVLVIGTPERKVQAQASKFHHSFFDAQPNVPRQPDVFQTLADCFDKITITQEFLVHPSEATAQIDTAIRGCIMQSLPVYIELPEDLVGSMVPVKGLVQRLDFNAPPHDAEIEQTVVASIMNKIRHAQRPVILVDAGVPSCGLTKEASQLAKKTRFPTAATQFSRGVVDETLKNFHGDISDFDMYGSYFRSSDLILLIGPLNTTKWAAPAVFEAKTAETVTFNRNSVVIGDQSYELFSRPVLQRILDCLTERKLRDLAPYPNLPNVRDSIEMLPSQRNTALLQHDIYSTFWRRMSLFFRPGDIILTETQTAQDGARSFVLPRDTTIINPGIRKFAGHMLATTLGVASAKQGLAKATCRLSHGRTVLFEGAKGFQEGRNDLRAIIDNKLNAIIFVINEGEPIVERLMHAMEYRQQDSGHWRYAESVSFFGAPNVTSYPVSSTIARTWGDIDIIFHDEMVQSGTGLHVVDVMVRPGDPNQSPCILTEIYGPPPSPFTLKKHHIKQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>W6PWN4</accession>
    <name>W6PWN4_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Malate dehydrogenase</fullName>
            <ecNumber evidence="3 12">1.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">MDH1</name>
        <name evidence="15" type="ORF">PROQFM164_S01g002022</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 12">
            <text>(S)-malate + NAD(+) = oxaloacetate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21432"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.37"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the LDH/MDH superfamily. MDH type 1 family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.37" evidence="3 12"/>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PWN4"/>
    <dbReference type="STRING" id="1365484.W6PWN4"/>
    <dbReference type="OMA" id="ASCAEYI"/>
    <dbReference type="OrthoDB" id="4069699at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030060">
        <property type="term" value="F:L-malate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01337">
        <property type="entry name" value="MDH_glyoxysomal_mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000013">
        <property type="entry name" value="Malate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.110.10:FF:000001">
        <property type="entry name" value="Malate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.110.10">
        <property type="entry name" value="Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001557">
        <property type="entry name" value="L-lactate/malate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022383">
        <property type="entry name" value="Lactate/malate_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001236">
        <property type="entry name" value="Lactate/malate_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001252">
        <property type="entry name" value="Malate_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010097">
        <property type="entry name" value="Malate_DH_type1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01772">
        <property type="entry name" value="MDH_euk_gproteo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11540">
        <property type="entry name" value="MALATE AND LACTATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11540:SF73">
        <property type="entry name" value="MALATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02866">
        <property type="entry name" value="Ldh_1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00056">
        <property type="entry name" value="Ldh_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000102">
        <property type="entry name" value="Lac_mal_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="LDH C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00068">
        <property type="entry name" value="MDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10 12" id="KW-0520">NAD</keyword>
    <keyword evidence="5 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Lactate/malate dehydrogenase N-terminal" evidence="13">
        <location>
            <begin position="25"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="Lactate/malate dehydrogenase C-terminal" evidence="14">
        <location>
            <begin position="170"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="200"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="30"/>
            <end position="36"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="140"/>
            <end position="142"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CDM28211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="340" mass="35860" checksum="7E75EBE861365730" modified="2014-04-16" version="1">MFAARRTVNLFQKRAFSASAFNASKVAVLGAAGGIGQPLSLLLKLNPRVSQLALYDIRGAPGVAADLSHINTNSTVTGYKPEGTGLKDCLEGSEIILIPAGVPRKPGMTRDDLFNTNASIVRDLAKAAAEAAPKALVLVIANPVNSTVPIVAEVYKARNVYDPKRLFGITTLDVVRSSRFISQVEKTNPANEAVTVVGGHSGVTIVPLLSQSSHPSISGEVRDALVKRIQFGGDEVVQAKDGAGSATLSMAMAGARFAESLLRAAQGEKGVIEPTFVDSPLYKDQGVDFFASRVELGPNGVEQILPVGKVNEYEQGLLDASLVDLKKNIKKGVDFVKANP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W6PWZ0</accession>
    <name>W6PWZ0_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g002092</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PWZ0"/>
    <dbReference type="OMA" id="TPTFANE"/>
    <dbReference type="OrthoDB" id="3438016at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004881651" evidence="1">
        <location>
            <begin position="19"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM28281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="124" mass="12881" checksum="B70C0AA3243E3C26" modified="2014-04-16" version="1">MRFSRILFPLAFAPLALAAPEPRPNPVAAPAPATTGGLLEELPELLSGAQSLLSTDNINKLDTILDGAAKLLAADNIDILQDILTNAHSLLTKSFVNNTTTLIGDATPLVEDISKLLGGVLGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W6PXE1</accession>
    <name>W6PXE1_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphatidylethanolamine-binding protein PEBP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S01g002262</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PXE1"/>
    <dbReference type="STRING" id="1365484.W6PXE1"/>
    <dbReference type="OMA" id="WTVVICP"/>
    <dbReference type="OrthoDB" id="2506647at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030414">
        <property type="term" value="F:peptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030162">
        <property type="term" value="P:regulation of proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046578">
        <property type="term" value="P:regulation of Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00866">
        <property type="entry name" value="PEBP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.280.10">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008914">
        <property type="entry name" value="PEBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036610">
        <property type="entry name" value="PEBP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035810">
        <property type="entry name" value="PEBP_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11362:SF148">
        <property type="entry name" value="CARBOXYPEPTIDASE Y INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11362">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01161">
        <property type="entry name" value="PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49777">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM28451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="181" mass="19877" checksum="E40DAF91CDEBA64A" modified="2014-04-16" version="1">MVTIVSAQIPESDTVLQVQYGSVTFKTGEKLRLSDITSAPSIGLSAPALTGTYIVIMIDPDAPDPTLPIFTQVLHWVQQDLIFSPMAGKYNTFVPLITPSPAPAAAPYLPPMPPPLLAPHRYIQTLFRQPAEFSINDLDLYLADSILRFGFNLSRFAQENMLGEPIASNFFLAGDETIQIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W6PXG8</accession>
    <name>W6PXG8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Hydroxy monocarboxylic acid anion dehydrogenase, HIBADH-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PROQFM164_S01g002456</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HIBADH-related family. NP60 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PXG8"/>
    <dbReference type="STRING" id="1365484.W6PXG8"/>
    <dbReference type="OMA" id="VYSNRTM"/>
    <dbReference type="OrthoDB" id="435038at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029154">
        <property type="entry name" value="HIBADH-like_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015815">
        <property type="entry name" value="HIBADH-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051265">
        <property type="entry name" value="HIBADH-related_NP60_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43580:SF8">
        <property type="entry name" value="6-PHOSPHOGLUCONATE DEHYDROGENASE NADP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43580">
        <property type="entry name" value="OXIDOREDUCTASE GLYR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14833">
        <property type="entry name" value="NAD_binding_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000103">
        <property type="entry name" value="HIBADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphogluconate dehydrogenase NADP-binding" evidence="5">
        <location>
            <begin position="3"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyisobutyrate dehydrogenase-like NAD-binding" evidence="6">
        <location>
            <begin position="174"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000103-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM28645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="311" mass="32623" checksum="E93D6095C8446CB2" modified="2014-04-16" version="1">MPQIGWYGLGSMGLAMASNLQRHLATKKALSLIYSNRTMSRGAPLQALGAIPVANFEKLVSQCGIIFTMISNDAVLQSLLSTAMGSSQSLKDKIFVDCSTVHPDTVKSAVSELKSKGASYVAAPVFGGNPIAVDGKLVFAIGGPKSATDAVKPLIQDVMGRRVIDCGEDATKASLLKIAGNIVTVNMMEAVGEAQVFAEKTGLGTGPMEELIGEAFGAVAGGYSKRLTTGAYAPPLDSHPGFGVSLAIKDARHAMSMAQDQGVELPGLEIAKTNMEAAREYGGECLDSSSMYGILRQKAGLAFWNEKSRKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W6PY49</accession>
    <name>W6PY49_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glutamate-5-semialdehyde dehydrogenase</fullName>
            <ecNumber evidence="2">1.2.1.41</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Glutamate-5-semialdehyde dehydrogenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Glutamyl-gamma-semialdehyde dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">pro1</name>
        <name evidence="13" type="ORF">PROQFM164_S01g000713</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the NADPH dependent reduction of L-gamma-glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-glutamate 5-semialdehyde + phosphate + NADP(+) = L-glutamyl 5-phosphate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19541"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58066"/>
            <dbReference type="ChEBI" id="CHEBI:58274"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.2.1.41"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the gamma-glutamyl phosphate reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.41" evidence="2"/>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PY49"/>
    <dbReference type="STRING" id="1365484.W6PY49"/>
    <dbReference type="OMA" id="KTQRYGT"/>
    <dbReference type="OrthoDB" id="1934954at2759"/>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00360"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004350">
        <property type="term" value="F:glutamate-5-semialdehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07079">
        <property type="entry name" value="ALDH_F18-19_ProA-GPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000006">
        <property type="entry name" value="Gamma-glutamyl phosphate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00412">
        <property type="entry name" value="ProA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012134">
        <property type="entry name" value="Glu-5-SA_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000965">
        <property type="entry name" value="GPR_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001221">
        <property type="entry name" value="PRK00197.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00407">
        <property type="entry name" value="proA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11063:SF8">
        <property type="entry name" value="DELTA-1-PYRROLINE-5-CARBOXYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11063">
        <property type="entry name" value="GLUTAMATE SEMIALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000151">
        <property type="entry name" value="GPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="12">
        <location>
            <begin position="12"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00059423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00060997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00075718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00077451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDM26904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="457" mass="48982" checksum="F8C43FCCD39C3DFC" modified="2014-04-16" version="1">MSLTESVAVDVAHSASLASRRLATLNNDDRNKALTLLHDALEMNQKDILEANARDVKLATIAADNGDLSHSVLKRLDLSRPGKYKDMLDGILSVRDLDDPIGKVTLRTLLDDGLTLERVSCPIGVLLIIFEARPEVIANIAALAIKSGNAAILKGGKESMESFAAIANVVSKAIAESRVPVSSIQLVKTRDAVSSLLAQDSLIDLVIPRGSNELVRFVKDNTKIPVLGHADGLCSAYIHADADIDTAVKVIVDSKTDYPAACNSLETLLVHEDTLELVFPAVAAALLEKGVTLRCDPDSKSALTKTLPAEKSVQVQTATESDYNTEFLDLVLAVKTIPSTDPPIAAVEAAITHINMHSSKHTEIILTRSKEAADMFMGGIDSAGVFWNASTRFADGMRFGFGTEVGISTNKIHSRGPVGLEGLTIYKYLIRGNGHGAADYDGEGRKKYLHTRLPIGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W6PY54</accession>
    <name>W6PY54_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 11">D-xylulose reductase</fullName>
            <ecNumber evidence="9 11">1.1.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Xylitol dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">xdhA</name>
        <name evidence="13" type="ORF">PROQFM164_S01g003005</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 11">Xylitol dehydrogenase which catalyzes the conversion of xylitol to D-xylulose. Xylose is a major component of hemicelluloses such as xylan. Most fungi utilize D-xylose via three enzymatic reactions, xylose reductase (XR), xylitol dehydrogenase (XDH), and xylulokinase, to form xylulose 5-phosphate, which enters pentose phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>xylitol + NAD(+) = D-xylulose + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20433"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17140"/>
            <dbReference type="ChEBI" id="CHEBI:17151"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="11">Binds 1 or 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="8 11">Carbohydrate degradation; L-arabinose degradation via L-arabinitol; D-xylulose 5-phosphate from L-arabinose (fungal route): step 4/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.9" evidence="9 11"/>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PY54"/>
    <dbReference type="STRING" id="1365484.W6PY54"/>
    <dbReference type="OMA" id="FETWYAM"/>
    <dbReference type="OrthoDB" id="3941538at2759"/>
    <dbReference type="UniPathway" id="UPA00146">
        <property type="reaction ID" value="UER00577"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046526">
        <property type="term" value="F:D-xylulose reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003939">
        <property type="term" value="F:L-iditol 2-dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042732">
        <property type="term" value="P:D-xylose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019569">
        <property type="term" value="P:L-arabinose catabolic process to D-xylulose 5-phosphate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006062">
        <property type="term" value="P:sorbitol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05285">
        <property type="entry name" value="sorbitol_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000068">
        <property type="entry name" value="Sorbitol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045306">
        <property type="entry name" value="SDH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161:SF9">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11" id="KW-0520">NAD</keyword>
    <keyword evidence="5 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 11" id="KW-0859">Xylose metabolism</keyword>
    <keyword evidence="4 10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="12">
        <location>
            <begin position="13"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00026119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU369026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDM29193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="354" mass="37888" checksum="3B82DD5E0C0C2652" modified="2014-04-16" version="1">MATPENLSFILQGVHKVTFEDRPIPELKEPHDVLINVKYTGICGSDVHYWEEGSIGPFVVTDPMVLGHESAGVITQVGSAVQSLKVGDRVAMEPGIPCRRCEPCKAGKYNLCEHMRFAATPPYDGTLAKYYVLPEDFCYKLPERISLQEGALMEPLSVAVHIVRQARVSPGQSVVVFGAGPVGLLCCAVATAFGASKVIVVDIQQKRLDFAKDYATTATFMPKNVPATENAERLRQENGLGLGADVAIDASGAEPSVHTGIHVLRNGGTYVQGGMGRSEIIFPIMAACSKELTIKGSFRYGSGDYKLAVGLVASGSVDVKKLITDTVKFEDAEKAFVEVKAGKGIKTLIAGIDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W6PYD8</accession>
    <name>W6PYD8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SET domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S01g003085</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PYD8"/>
    <dbReference type="STRING" id="1365484.W6PYD8"/>
    <dbReference type="OMA" id="HQEATWL"/>
    <dbReference type="OrthoDB" id="308383at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="2">
        <location>
            <begin position="315"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="269"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM29273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="448" mass="51006" checksum="8E293AE41AAC6DB1" modified="2014-04-16" version="1">MAYVPQITNKKAKKVKTVNTPNTTIKKTTNRKTARKSANRKTTKKAPNPPVDLNKLFPSWGSEDALNQTANKEATDIILAVYHDINAYCNLERHARNKVYGSQETFYNLLVFTEGFVEREIGYYTSCVESFKAEHGEFQPVTPNSRFLEFVTGLGWKMFAIFSHAEAFRRGIKEADDRTWGLLLEKIHENSMSIELYAHSRTLKWRNILQVYQDNPIPGLPDMKPEIETYMGWKVDHPHHTVITLDGKLKEPTYNGKLQQHINESIYDPKKWSGQKQDPTLRKKPNGSSTNVGRNCVLCGSPVSCDCRLKSRAGELVELREYTEKGTGVRALARFGRGDILDIFMGELLPHPAEDVYPLTQSDDKLKFSNLCTICPHQFGNWTRYISHSCRPSTQFMTRTIGKRVVCTVEAIRDILPFEEITVSYGNKYWESVGYNCLCGHCDGSGTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W6PZB2</accession>
    <name>W6PZB2_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Nucleolar pre-ribosomal-associated protein 1, N-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PROQFM164_S01g002877</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PZB2"/>
    <dbReference type="STRING" id="1365484.W6PZB2"/>
    <dbReference type="OMA" id="RYITFKR"/>
    <dbReference type="OrthoDB" id="72892at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059018">
        <property type="entry name" value="HEAT_URB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039844">
        <property type="entry name" value="URB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032436">
        <property type="entry name" value="URB1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021714">
        <property type="entry name" value="URB1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13500:SF0">
        <property type="entry name" value="NUCLEOLAR PRE-RIBOSOMAL-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13500">
        <property type="entry name" value="NUCLEOLAR PRERIBOSOMAL-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26140">
        <property type="entry name" value="HEAT_URB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16201">
        <property type="entry name" value="NopRA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11707">
        <property type="entry name" value="Npa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="URB1 N-terminal" evidence="2">
        <location>
            <begin position="101"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="URB1 central HEAT repeat" evidence="4">
        <location>
            <begin position="637"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="domain" description="URB1 C-terminal" evidence="3">
        <location>
            <begin position="884"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="820"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="820"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="832"/>
            <end position="841"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF26140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDM29066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="1128" mass="126619" checksum="D44F37066CE9BD90" modified="2014-04-16" version="1">MSHITEHPSRAKRRKIDDPKPEKTAVISNIKSAASLRELLAVQQNAPLAKQGIIKFKEFLVSIAHTENESEKAEKLRVLKDYCDKQITNSGKEDETSVCFADIIQSWSFGDGNNNEPLLTSVPSVLAIFLKTISSELEFREFGIALCKHLLQKDQLRLFNRGLTATKSKEHLISPCLRLLTEIVTFDGGAVARQLYLRRYITFKRLEVFLAPNKAQEISGDESHKSTLRRNAQRYLLANLRVQHASEKGDIIEQHKITRSFLEYIRKDPRDTVLEIIKAIERDVVQDSALSRKSKSKFFNRHNLERLVTLYGYDRESDEPNAGGVVIANEIHRVMMNVCKTAGLGVLLPETGWYPVGTDPETLPVDDDTCIELGLDSPIYVDKYRESIPVRNGSLSFLIQCLRPDVDSLQIELLVSIFRVAPELVADYFSRKTMFISDPKATPSWMAESAFLFSTVQLPVPANCGWKDKQPILPPPVSVVIENILPRPLGQKIMTRCLNQNAEIITLFAVRILTLAFTKLRAVLKIFQADHGQGQLFWNQASAKLLAEFSRRCPAVKDVVVLFRRTEREDLTQQEAVAELLTCYYEVMPDIALEENFDVSLVLVDVLKRLEAPDISADDSESLLSQLQSILQIAQQSASLRWWQKPASMQYSPFTSILKVLMDTSDKDSSRRISTLFKTVLVDNSVLQSSPHAFASVLSSLENSEADALHQQLVFFDNCVSRVAKKPVHYQDLLQSLSEDVSRTTSALVAAIVEQWPFVVKGGDASTEAAVGAWIASLLGNLKQAGESTKVLKAARDALVEATETKKIKSLLKKSVKEADDADNEDKMDIDSGSNVPSSSNKASAVDLDEIFGSLPTEGTTHNALNKWEREDIAEAVDQGHVAELMLCICSQHEEVRRQAFANIIRFMAKLKDSTYAEWRTVFTLAGELLETVNNIGMEKPVPWIVGECASNCLEVLIDPLHKVYGKVNKFLQKAPLWEVEKIPTYWVDKILLHEPELDDGYFDEIDWLLNLFIKALRTEADMEVYRRANVFERILSLYQSPTLGPAARRKILHIVYRAAQVGGSTTLITRSGVISWIQIQAAEADTKEAAQLAALARALYETCDRERVDDWSNGTLGRVVDEIQAQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W6PZK9</accession>
    <name>W6PZK9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Isopenicillin N synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PROQFM164_S01g003287</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PZK9"/>
    <dbReference type="STRING" id="1365484.W6PZK9"/>
    <dbReference type="OMA" id="WENVQSH"/>
    <dbReference type="OrthoDB" id="406156at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044283">
        <property type="term" value="P:small molecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050295">
        <property type="entry name" value="Plant_2OG-oxidoreductases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47991">
        <property type="entry name" value="OXOGLUTARATE/IRON-DEPENDENT DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00682">
        <property type="entry name" value="IPNSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="5">
        <location>
            <begin position="205"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDM29475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="401" mass="45798" checksum="1896A9F3D960FB9D" modified="2014-04-16" version="1">MAVSAPFNPPSADLPGKPFVPTWVPPPITQQKENFAELSSIDLSLLDSDDPAVVDKLVQQVKGAIRDDGFLFLENYGISLEQLHRQFSLAQYLYQNISEEDKERLLFDPETGVWSGYKHPYGFKRERGPEDGIEQFNWYKPDWSDINRVPKCLHPFMDEIEEFANYLTKSVNRRLLTLFSRVLELPDDYLWDNVQSHGCPTGEGYFRHALFRPVQKKTEEASKGLRMHGHTDFGLTTLLFSVPVSCLQIWGRDEKWYYVPYKPGALVINIGDTLEIVSGGHFKATRHRVYKPPVDQLQQERLSLVLFNSSVGDLRMGPATASPLIQRVGCVEEQGVYKEFKSLTSQGKLVPTNRQWREIQIATATDPTDQERNRVGADQVLIDGKIMHQREYMGVKVVLPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W6PZV1</accession>
    <name>W6PZV1_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Amino acid transporter, transmembrane</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PROQFM164_S01g003387</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PZV1"/>
    <dbReference type="STRING" id="1365484.W6PZV1"/>
    <dbReference type="OMA" id="AMLMTHI"/>
    <dbReference type="OrthoDB" id="40134at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000039">
        <property type="entry name" value="Neutral amino acid transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF683">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="125"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="234"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="267"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="309"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="349"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="379"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="414"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="8">
        <location>
            <begin position="46"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM29575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="467" mass="50276" checksum="B3BF1E83739AEA90" modified="2014-04-16" version="1">MMDIKNEKDLEGLDPSQSREIQNSHINNHDDVFGEITESGPNYRNVGWAGTVILMMKSQIGLGVLSIPSTFDTLGLVPGVICLIVVAVITTWSDYMVGVFKLNHRSVYGIDDAGYLMFGVIGREVFGFVFCLYWIFVAGSGMLGLSIALNSVSSHATCTAVYVAVAAVAGIIFASIRTLGKISWLAWIGLTCILAAIFIVTIAVGVQDRPASAPQEGIWVSDYKIVASPKFSEAISAVSSIIFAYAGTPAFFSIVSEMRDPKYYTRSLIICQSSVTAVYVTIGVVVYYYCGSYVASPALGSAGDTMKKVSYGFAIPGLLVTVMLFVHLPAKFVFVRALRGSKHLTSNSMVHWGSWIGCTAAVGIISYVIASAIPVFDSLVSLIGALLGTFMCFQPMGCMWLYDNWGKGKVDRSPRWMFMVSWSVFVIVIGSFMMVAGTYGSVVSIMDSYKANGGSAAWSCADNSNSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q135</accession>
    <name>W6Q135_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Beta-lactamase/transpeptidase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S01g001740</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q135"/>
    <dbReference type="STRING" id="1365484.W6Q135"/>
    <dbReference type="OMA" id="KMGEQWE"/>
    <dbReference type="OrthoDB" id="10250282at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058664">
        <property type="entry name" value="ARB_00930-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051478">
        <property type="entry name" value="Beta-lactamase-like_AB/R"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22935:SF97">
        <property type="entry name" value="BETA-LACTAMASE-RELATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22935">
        <property type="entry name" value="PENICILLIN-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26335">
        <property type="entry name" value="ARB_00930_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004879835" evidence="1">
        <location>
            <begin position="19"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-lactamase-related" evidence="2">
        <location>
            <begin position="109"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-lactamase-like ARB-00930-like C-terminal" evidence="3">
        <location>
            <begin position="442"/>
            <end position="583"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF26335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM27929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="584" mass="62678" checksum="04E862C83EB25E89" modified="2014-04-16" version="1">MPSISYAPFFLLFSSALSFTPCPLLGPAFPPFSLDTNDKTVAGALQKLTQKFDTLVATNNGTHGDTSPNTTFSIALFSSDAGNAEDEPFFWQYHHTAPILNQSLVGSHTADKDSIYRIGGLTEVFTVWSLLLAGDGDQIFDDPVTKHLPELIDNTTREQDMNGRVRWEDVTVGQPASHMSGIVRDYCSTDVTLQTSSAEAGLPPLQAISIPCCGGDSKCDSSDFIRHLANQTRVAPAGETPIYSNMAFQLLGYIVEKRTGKPFSKVLHHIFDVLGMAETSIFAPNSTTAGIIPVSKEASGWSAHLEADIAQCTHCRSKSIFSSVKDLATAGQAILNSTLLSKPQTNRWFKPVSHTSNPANSIGSPWVIYSAGSYPNTSMVDIYTVLSNEGNDKSLYSSYLGLVPDFGVGFAILSADSDTPADLNAHADDIGDVVLTALMETATEQAARNFGGEYKVSNINSSIVVEYDSLPGLYIQEFVSNGTDFRATLAGLVGVAKPADLSIRLYPTQLVEDSGSGSKQGFRAVFQDVTELADAGTATCVSWLDIGRLRYGGHGLDEFIFSLDQSGQAVSVEIPALRISLQKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2024-10-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q1B8</accession>
    <name>W6Q1B8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S02g000274</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q1B8"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM30125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="76" mass="8723" checksum="0550497851A4D99F" modified="2014-04-16" version="1">MKPITSEHEPQTTQWDEGQVYVKTCHNATRKALALLLSRSNEENLHITTTELELSSGDPLDYGPRFVNPFAYYVIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q1I0</accession>
    <name>W6Q1I0_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S01g003619</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q1I0"/>
    <dbReference type="STRING" id="1365484.W6Q1I0"/>
    <dbReference type="OMA" id="NRCWPAC"/>
    <dbReference type="OrthoDB" id="4843554at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004881213" evidence="2">
        <location>
            <begin position="21"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM29806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="216" mass="22334" checksum="C3C2388F8320F38B" modified="2014-04-16" version="1">MHTQQLLPICGLLLASIAIASKLDRDDVPNRCWPACSSVVGIAKSCDAKYERDSAEIQCICDWDAAKTEIPLCSACITQYQTDRRNHNITQHDDDNDDDDDDDNDDDNEALDLVRSCSLTTTTYSAAATTLIGTSTSTESTSTATSSTATITDSSSTSGGSQDSTSSVSSGSSDSAGASSGSASSPTPTPDAAASISAPGATSMLGFMGLMAFAWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q1S5</accession>
    <name>W6Q1S5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Zinc finger, C2H2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PROQFM164_S02g000080</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM29931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q1S5"/>
    <dbReference type="STRING" id="1365484.W6Q1S5"/>
    <dbReference type="OMA" id="HGDVTKH"/>
    <dbReference type="OrthoDB" id="3544487at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="entry name" value="Intergrase catalytic core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021842">
        <property type="entry name" value="DUF3435"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37535:SF2">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G09300)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37535">
        <property type="entry name" value="FLUG DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11917">
        <property type="entry name" value="DUF3435"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="4">
        <location>
            <begin position="624"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="540"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="411"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="30"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDM29931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="661" mass="75245" checksum="EDB3C827D1DBBD28" modified="2014-04-16" version="1">MSFDGSVPSNESDTTPGHSEVFSDHASDTDSSTEPSVFDSSSESEDESEDELVSEEEEEQLPPEYYLHEAESLDDQFCKGTKRDPVECLFWLSNTEETWHLIYKAEVGHGVSKDVHIKIRDVLAIVVTEKSLSLKGRPKVTMYVEDVAEFTRVVLSTTEMTFPYGWYRIQLLLFCQLAAITGNRPGALLKLRFQDLKLTLVRDPNDGRPRLFIYLRPEFTKTFLGGKESNTFPIPEIIFDPTLVLSPHVFLLGMLFRIGAFKSLSKDGPVMDCPEKLYCLRVLHGLSEQELKLKDEILDQNVFCQALREPGGIRIAPEEKLTKGWLSYRMKRGGEIIGFAEVAKPYCLRYSAAKAFNDSPDMSNELQNVILQHASIDTFIRHYSKRTYENTRAALQREFGDKLSGENFPHSRMIRKRRKAQEKRVKRLQQKFDHIDKQNHLIHENLERYKNEQPVVDSERQLSGKVINKEVLVELERTGYMTPQHITLIDTVLTMPGTTIEKEYERRIAVINAVIAVCDTEEVTPSRSCIARKRSADASDMLPTAPLPKRQNSTPSAKSDDAFSKAIASVYVKSPEERPTIYFICLSTPRLPQSERLRMYKNSGSLSRHFVSKHIKPFSNDMRCECSICGEKLESKSMLLNHAERVHGTVSRSSKTALGLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q1X6</accession>
    <name>W6Q1X6_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S02g000429</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q1X6"/>
    <dbReference type="OMA" id="YGCCISW"/>
    <dbReference type="OrthoDB" id="3705032at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046925">
        <property type="entry name" value="WD-like_fungi"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20493">
        <property type="entry name" value="WD-like_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004879331" evidence="1">
        <location>
            <begin position="22"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="WD-like" evidence="2">
        <location>
            <begin position="68"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM30280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="270" mass="28877" checksum="176FBCA23C899606" modified="2014-04-16" version="1">MFKRLSISAWAIAVLATTAQCQQLSYEDSIAALAYGNVATDTSSAGEVWLNVTGFAVEELPHIQSDVGIHTLDNLETLTAIAGLAQDAAKRGQWGDIVYLHSAFSMNGHVDHLNVSSVEMQESLLEAVTNRTSGKTDSPLVELYANTSSSTFLAEAFKNLKSDANPQRKRWTKEACSTAHRAVTSACRSLLGNINDNATWKSGGPRNICQYGCCISWSANATFQLQNLSSAGNYCVNACASSTVSCEIYGVTLQGTVVDQCLSNRANGCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q2E3</accession>
    <name>W6Q2E3_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S02g000629</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q2E3"/>
    <dbReference type="STRING" id="1365484.W6Q2E3"/>
    <dbReference type="OMA" id="KIPLQSC"/>
    <dbReference type="OrthoDB" id="5296964at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM30480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="164" mass="19347" checksum="DF69EF35A33E11D4" modified="2014-04-16" version="1">MPSRGPTIRSQAHSTPRDRRHDHGRHYELHLQICKPQGGVIHWMLVTRHPHSQSCTRLHSTGYMGNRNLEIEYNKRFDSWSVESTHLLGEIHRDNIHTVEAEAREVPLQSCQLWACYLMLRLERRGLLAEGTFDHYMNCYEHKREENYGPGHDHHHHVCPVHGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q386</accession>
    <name>W6Q386_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="10">GTP-binding protein rhoC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">rhoC</name>
        <name evidence="10" type="ORF">PROQFM164_S02g001213</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rho family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q386"/>
    <dbReference type="STRING" id="1365484.W6Q386"/>
    <dbReference type="OMA" id="RTKRTCI"/>
    <dbReference type="OrthoDB" id="8830751at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032506">
        <property type="term" value="P:cytokinetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04132">
        <property type="entry name" value="Rho4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000678">
        <property type="entry name" value="Rho GTPase Rho4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0488">Methylation</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0636">Prenylation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="251"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDM31063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="289" mass="31757" checksum="1A2668C19EEFD564" modified="2014-04-16" version="1">MSAMYEDQYNAASRRRSLVTPPPSLTPRHSRTRSDSIRVSHGTASTNTSVSSGRMSEATNITQPPSFSKKFVVVGDGGCGKTCLLISYSQGYFPEKYVPTVFENYITQTTHRASGKTVELALWDTAGQEEYDRLRPLSYPETDLLFVCFAIDCPASLENVVDKWYPEVLHFCPTTPIILVGLKSDLRNKRTCIELLKTQGLTPITPEQGENVAQRMGATYAECSSKEMRGVDEVFAKAVDSAISIEEQGWVAPQPAGRNNRNNRASAVPSGGGGPRPGKKIKKRTCKIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q3K8</accession>
    <name>W6Q3K8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S02g001055</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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</entry>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
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                <person name="Abraham A.L."/>
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                <person name="Dupont J."/>
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        <source>
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        </source>
    </evidence>
    <sequence length="1435" mass="156592" checksum="974B4061B14BD0AA" modified="2014-04-16" version="1">MRLHLVISRHGLPVTRILWTTTSSTSVLGEYGTQRPASTAAVASSRTPNIAFSNGGYTVAQLLEDVNEVVPLETEPSIFDTEFSGQWGLEDYVVEVAGSECLHFMEVDGLLRDGDEVVIRALQLADLRTRRLCGRHQITAEGKHLIDGVPFGSPFLKRTTSTRPAITIPPRKKRRTVFSGWDHAPELVAEEVHADEEGDGEWLPHPNTGFGKELSVMPAEHEESLGTVIRHPVDHATESDSEVDMSEMPEVEEDELESELQALKEDFDEASQFIDIRNQTRNASGHPLRATSIVKRPTSKGSLAAASSLSSKRSRAEDPSPRASKAVRFNKGDKQEDKEMPDLPQLPQAVHVQIEESAAATSDSGSSESSMSSSGSDSDDDSDDDSDNDSDDDSDDVDSSSEVEPAAEAPSDSHSSSSSDDSDSSDSDSEEEAAPSIPVSVGAPGGGSLRTKKNNQRIKLRRRLSKLKELGALPEKAGFDALRAWEDSHGGWHTPEQYLNPEPFVQPPKPVEPELEPEPEPAESSKKKQKREKKDQEQKEFEARRQKLLNDLALGNGVDVSEISEKENVPPAASAVGDTPVSEEISGKEEPEQEPSNRRTLDIASSRRMLFGSLGMRTPKTKEDEEETRRKLAAKASACGPRNKPSKQDIGEEADQMQEEEDASDIDWQNKLVIRAVECLYPQVDMTAPPYPFVQRWDKEANALIRELKGPSKKRKRKQRVQVYEGHEQEEYDENGYYYGHDDKYQANDQPNNGYYEGEADSHYEGQWEGEAAPYYEGHYAGEAEGDQIDYDDAPEPGQAPNPTLDDLPAIPADMSSVPGLTESEAKVGAIIAFRQLDMSKATNWQPQMSEYRVAEVRSIKDHGVINVLLAKRDRKPHSASSEYDEPRRFSKFEVPDLANDEGEDDGYRELAFAELSDPKLIQPAAQSGAEFEGQNREGSIVSVVHESVLNAQPTLSEEMYIDDTTIVTIGNEVSHIESPRESPGMPDEPIQQTPGRDLPQIQVQSGSIQRSVTPPIPSPSFTGFHSARSWQQMTPGVEFSRELEGHTLIGGDTPSALVNRDEDPSALSYASANQSFADETEDQEMSEHQEHERQIVSENILPPGDSGDSGPQSGSLLSTIDRSGGNGGQGGNSSDDDASDSDSLFVKSDTKREKHSVAPTSSSESWKDLLNRLRNGPPDPDSNNSSNSEANSEANSEANSEANSEANSEANSEANSEANSEANSEANSEANSEANSEANSEANSEANSEANSEANSEANSEANSEANSEANTIAKTTTANLQHSYLDLNFSSLDFPRPSNSHSPNPPTSAQPDAQSQKQTSILSPFETKPAATTRSILSQRVHEPESASQILSSQASEVIDLTSSPRESPKPSSSDPNPSQRSKSAVYGKSQRSKDIPRSSGRPPRASTGRLQHMVEVSISPSSQKKKRSARKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q4V6</accession>
    <name>W6Q4V6_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="5">D-aminopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">dap</name>
        <name evidence="5" type="ORF">PROQFM164_S02g001839</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S12 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q4V6"/>
    <dbReference type="OMA" id="EYSYCNV"/>
    <dbReference type="OrthoDB" id="5946976at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.50">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050491">
        <property type="entry name" value="AmpC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027279">
        <property type="entry name" value="D_amino_pept/lipop_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012856">
        <property type="entry name" value="DAP_B_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009622">
        <property type="entry name" value="PRK13128.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46825:SF9">
        <property type="entry name" value="BETA-LACTAMASE-RELATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46825">
        <property type="entry name" value="D-ALANYL-D-ALANINE-CARBOXYPEPTIDASE/ENDOPEPTIDASE AMPH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07930">
        <property type="entry name" value="DAP_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50886">
        <property type="entry name" value="D-aminopeptidase, middle and C-terminal domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="1 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 5" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase-related" evidence="3">
        <location>
            <begin position="17"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="D-aminopeptidase" evidence="4">
        <location>
            <begin position="353"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDM31688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="537" mass="59091" checksum="E662AFB7903ACA0D" modified="2014-04-16" version="1">MAIDEKVQAVLNKTVLRYRGPGGAIAVVKDGEVIGQRVWGFADLDQRIPMTAQTQIPICSITKQFVCALLIDLERNPTPTLAAKGDVRKQLSDHLAEILSPELTSDGELTIDRLCDMQSGMRDYWAMTTLWGSKPDDEFLIARDCGPLLARTKSFMFQPGTEYSYCNVNFHVLARIIERATGESLAKLLEKRILRPAGMSTAFLCPNTAHHPPPCVGYEGDEQHGFTAAVNRMEWSGDAGLVASLADMIEYEKYLDRCYADPQSWYHTAIAAPKFKDGTPAKYRYGLDHADIAGVNTIGHGGALRGYRLHRRHAPRERLSVVVMSNSDFGAFGPNMEILHELLGIPKPVASTVQPAADWVGAFLDQDTQLSIVITKGARDGEVAIRYDGSAEPIKLSAPNHGKSDSMVATIDGDFLSIHRVVDNRILSARRIVPKESILKGTSFQGVYHCAEIESTFHCIGEDGMLYGAFDGYLGQGIATPMKYLGDDVWVLTCPRGLDAPAPGDWTVVFSRDEHDAIQGFTIGCWLARKVDYVKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q521</accession>
    <name>W6Q521_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">J domain-containing protein spf31</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">spf31</name>
        <name evidence="3" type="ORF">PROQFM164_S02g001595</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q521"/>
    <dbReference type="STRING" id="1365484.W6Q521"/>
    <dbReference type="OMA" id="EIVNKAW"/>
    <dbReference type="OrthoDB" id="342454at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46620">
        <property type="entry name" value="J DOMAIN-CONTAINING PROTEIN SPF31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46620:SF1">
        <property type="entry name" value="J DOMAIN-CONTAINING PROTEIN SPF31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="37"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM31445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="215" mass="25743" checksum="2E3F0474C3C7CA43" modified="2014-04-16" version="1">MSDDEPDQEFLEALEKEASEFKKDVEIDRIRSAFKLDSYAVLDLQPGVTEKDIKVQYRKISLLIHPDKTKNPAAPDAFDRLNKAQEALLDEKQREYLDECISDARRLLIREHKYTLDSPELKTEEFKVEWRKKTISVLLDEEARRRRQLKARLQEEGREQRKEEEELEARKRKRENDKKWEETREERIGSWRDFQKGRKPGGDEKKKKKKMKVLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2024-10-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q5B0</accession>
    <name>W6Q5B0_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S02g001979</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q5B0"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM31828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="76" mass="8614" checksum="E00E1E2CAE64F225" modified="2014-04-16" version="1">MQLFVCFPTAAAPGNRGGDLLAAEVGCSWIDMSRRVRIWVLRAWMSTDDYRPTLAPHVHAQGPTHIEFLSFKHKTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q5F7</accession>
    <name>W6Q5F7_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Basic-leucine zipper domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S02g001366</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q5F7"/>
    <dbReference type="OMA" id="YKDEDMW"/>
    <dbReference type="OrthoDB" id="3555317at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40618:SF1">
        <property type="entry name" value="B-ZIP TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40618">
        <property type="entry name" value="B-ZIP TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="3">
        <location>
            <begin position="57"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="77"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM31216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="441" mass="49471" checksum="6989D4C965C72353" modified="2014-04-16" version="1">MKPSVLLLLGMRAWHSDIQESPEVHYEPSYPQWYGVRSTAMPTGQVKRTSLGRPRKPAEDAKSIRRAQVREAQQAYRSRQQSQLSSLKARVEQLEDVLNQLSQTVHAFDNQLIQHGSQWSQPQLLQTVQLLRDDIMSHFKRADIHFQESTEDQPSELSQAVNEQPHALVASEVSAGRLKDHTSGSDFWKLFLGSSAGIIPSTNTQNLDNQSNDLVSIPVAPSIAETHTIQYATTPFTQRLFRACAESGHRFLSNLSYKDEDMWEFGLLLQRMPRAEIQRYFGRVIDMEPCNPIVDGRFPYVSLGGAGTHFLQPSSDSFSDSFALFRTANGVSHIPAVEDWFDVHDVERYLLNKGIIAGEFPSALTISYPFSPDARPSNLEIPQGELPGGMMMVIDEYKLINRLSQLPVALGCVAGFRRSDVERVVSHNVRWISVGFTGSTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q612</accession>
    <name>W6Q612_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Endoplasmic reticulum-Golgi intermediate compartment protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PROQFM164_S02g002294</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Plays a role in transport between endoplasmic reticulum and Golgi.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Endoplasmic reticulum membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Endoplasmic reticulum-Golgi intermediate compartment membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Golgi apparatus membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ERGIC family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q612"/>
    <dbReference type="STRING" id="1365484.W6Q612"/>
    <dbReference type="OMA" id="MTNHYLR"/>
    <dbReference type="OrthoDB" id="5541786at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033116">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045888">
        <property type="entry name" value="Erv"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012936">
        <property type="entry name" value="Erv_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039542">
        <property type="entry name" value="Erv_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10984">
        <property type="entry name" value="ENDOPLASMIC RETICULUM-GOLGI INTERMEDIATE COMPARTMENT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10984:SF81">
        <property type="entry name" value="ER-DERIVED VESICLES PROTEIN ERV41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07970">
        <property type="entry name" value="COPIIcoated_ERV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13850">
        <property type="entry name" value="ERGIC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Endoplasmic reticulum vesicle transporter N-terminal" evidence="7">
        <location>
            <begin position="23"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="Endoplasmic reticulum vesicle transporter C-terminal" evidence="6">
        <location>
            <begin position="190"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU369013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM32143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="396" mass="44682" checksum="A51B222C9BFE8967" modified="2014-04-16" version="1">MNGFESKGLDEDSFGGKPGLTALKTFDAFPKTKASYTTPTRSGGQWTVLILIICTIFSWSELKTWWRGTENYHFSVEKGVSHELQLNLDIVVHMPCDQLRVNIQDAAGDRILAGELLKRDDTNWLLWMQKRNTETNAGAHEYQTLSHEESDRLAEQEADAHVGHVLGEVRHNPRRKFAKGPRMRRGVLPDSCRIYGSLEGNKVQGDFHITARGHGYRENAPHLDHSSFNFSHMITELSFGPHYPTLQNPLDKTIAESEEHYYKFQYFLSIVPTLYSRGKGALDAYTHSPQTAAARHGRNTVFTNQYAATSQSTVLPESPMVVPGIFFKYSIEPILLLVSEERAGFLSLVVRVINTISGVLVTGGWLYQISSWAREVWGRRKNRSSEGYLTGKSSMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q6M9</accession>
    <name>W6Q6M9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hpc2-related domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S02g002509</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q6M9"/>
    <dbReference type="STRING" id="1365484.W6Q6M9"/>
    <dbReference type="OMA" id="MDGDVPM"/>
    <dbReference type="OrthoDB" id="5576775at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014840">
        <property type="entry name" value="HRD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08729">
        <property type="entry name" value="HUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hpc2-related" evidence="2">
        <location>
            <begin position="472"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="426"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="524"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="21"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="68"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="172"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="199"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="316"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="531"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="594"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="610"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="623"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="655"/>
            <end position="665"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM32358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="665" mass="69527" checksum="4B63048F59C93A8D" modified="2014-04-16" version="1">MSDPAKMGIQKEEGPVDDVKSGAGARRASGTARRSRRKKDDDPDKDKDKTKKDKEPKETKEKPPTQPTQPTQPTQPTQPTQPQIAPPPQPPQPPQSAPSSYSNTPSHTAPGASYQLSQPSRPQSQPPVPQPPPQRTSGQNFDPIRSAFDNPSPAPSYSPSTRAISPRNAYRASASPAISSIIDPPAQNSQPIYNTLQRSSSGHVSGLSSPALSAMVSTSPHPSLAPPVSSAARGAMHIPQAMSQSTPYTTPYPPTEQRPTPSQPPKPEPSPPVQPQPPAQPEPAVQSTPPRQQPTDSMEIDPTEQLEPSAKKEKSTATAPTSKASSPKPARSAKDAPQLPQGSGMITNALFGGGEEPAKSPDSRSAPSIIVHVPLQKGNQIVNFARLAEEQYGFAALHPRLAAHKARMARVAAAAAALERNDKTAKGISAGESADEDLSLDAERDSDMDGDVPMGGTGTGTNGAPSETSDGKKKRRKKVEEYDRDDPFVDDTEMVWQEQAAASKDGFFVYSGPLVPEGEKVQVERADGTIKRGRGRGRGTGRTRTVTSHPHVPIAAAVPVSQDTGLPLRGPGSRGGTSRRPRGNKRADGGSDRAATAAFAASASHESRGGRGGGTGSSGRGGTNSTRGGKSSISIPMPDLAPAPSGVAHGPPAPSSLSSPELMMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q6V6</accession>
    <name>W6Q6V6_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Monooxygenase, FAD-binding</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PROQFM164_S02g002236</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q6V6"/>
    <dbReference type="STRING" id="1365484.W6Q6V6"/>
    <dbReference type="OMA" id="AMPWIDA"/>
    <dbReference type="OrthoDB" id="1878542at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF147">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_2G01950)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="129"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM32085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="284" mass="31373" checksum="E867AAA2DFB0B365" modified="2014-04-16" version="1">MRGGGADVGVKDTHQAAYRIMIHKEQIKDDPELLALINSNRVTRWIGEKRHIIAYPVSNNTIYNLSTTQPDSHFASATNATYTTKGSKPAMMDVFSDFCPMVQRLLDYVPEGEVCEWKLRVHDPLPTWVLDSVALVGDACHPTLPHLAQGAAQAIEDGAVLGVVLSKLPDTTPQSINKALRVYERVRKSRAEALVDMATASGRALHLGEGAAKEERDKQFAALRAGKGPVPDKWADADVQREIYGFDCAKVAADDFDEYFQKIRILLPLLKPRGRFPILALNTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q7Y5</accession>
    <name>W6Q7Y5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S02g002969</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q7Y5"/>
    <dbReference type="STRING" id="1365484.W6Q7Y5"/>
    <dbReference type="OMA" id="IRDTEWD"/>
    <dbReference type="OrthoDB" id="4232626at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="99"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM32818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="516" mass="58932" checksum="43921C36418E13F9" modified="2014-04-16" version="1">MLNDVFRTSIMLIQRFSKTVYPSDTRHNGNLATWPDPCPLASSFFSIAVTVSSTSTYMSKTPYGRQPYHDNYISQPQEYEPWEQDSQYSPPTPGYFRSPYAPSSNCSPSPSTPPENDRSSARQRPSTLPLLQESEWEPEKAYDEDPPNCIHYFIEWRVTLNKKTVVKDTEEDLVLAPGAYWKLFLEEKLQTVLLEKVPRDKRVRVDDTAIMVSNSDRSQRDLNKRFNKTEIVWAPIEKQLRMWSSHFCRGKRLTLRVCFNYVEDCSYPPAGRKGEKRGKSSVTKRMLGDRDAQLDAEESSCGQQSIWRHVYDLMKCDSAACHLGPYCWLDPKGKKHYRLRTQTLRRLVTYAEKGGILETHRDVPDEIRDELYMEEQQREEKDKRKGSNILGSQMSHLPININVHPPGVATTASAVVTAGQKSVSSLKIPGLKDVAVKEYGEWLASNVSDDTLKAAFRQACGITLSDGFELEHIYKDQNPEFFVSKGIKPGIARSFVENIGDWVENVKKVLPVLELV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q866</accession>
    <name>W6Q866_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S02g000583</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q866"/>
    <dbReference type="STRING" id="1365484.W6Q866"/>
    <dbReference type="OMA" id="RFTDPTW"/>
    <dbReference type="OrthoDB" id="4366257at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM30434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="391" mass="43236" checksum="0ACD513FFE5EC875" modified="2014-04-16" version="1">MARVTAELRINMSPSHEGPIWAALGIDMATNTQDRLATQHLIKEIYNPILYNALQQGRPWNGTFRGHCGFEVRRRITARQHELPAVVLAHVPDSAELTERIFDVLRFYRFTDPTWRVTDPNYPIFEVFSLPAPAGGLAPRPGPGFSLLPAPTPAHAPAPTPARLTRARARARALVPSPAPVPVPVLAPVPTSGHTFTPVRTRNRTIFPVASPNPVPAPVFPVSPVPKAATKDTFWASDSRLLVAPEDIHSPIPDDFYTADTTEAPSPPRTEFGISTSTIEQGKRKRTSDDEKDGETSPPQKKRSKASRLPKEKVEWSTFTTLSDSSSNDEEILDADGDAWMGESFTPYKIKNKSVEPDSSVWSSMRDYFLLKAREPTPDDQDEEHGLEIGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q8Y6</accession>
    <name>W6Q8Y6_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Probable transposable element</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S01g000026</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q8Y6"/>
    <dbReference type="STRING" id="1365484.W6Q8Y6"/>
    <dbReference type="OMA" id="AYNETAD"/>
    <dbReference type="OrthoDB" id="3799035at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF463">
        <property type="entry name" value="REVERSE TRANSCRIPTASE TY1_COPIA-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Retroviral polymerase SH3-like" evidence="3">
        <location>
            <begin position="102"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase Ty1/copia-type" evidence="2">
        <location>
            <begin position="436"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="239"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="296"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM26217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="913" mass="101829" checksum="87C3705697A3C07F" modified="2014-04-16" version="1">MGDEMKFMLFSRAIQAEVTGVDQHQQNGVAERARKTIYDRIGPTLAHARLPSKFWPEIARTAAFLSNRSPSSKLNMTPYQAWYGDRPDLSRLRVIGSKGEYLIPPKQRKKLTDPRTRPCILLGYEGNTYYRILLGDGRIVGTPNAEFQEVLTTPSTQTMEDVGARQDGLLEATAAAAGGSETVGLINQPSVGIRQASVPASGYQLSMDPPERPLPKPRNDISHTLPRSDENSRVLTQPSDDNSQTQASAQSSDDDSQPAVAVQGDRTLSSTRSDDTLGPLSPAYQDSVLGTDLPSGGDQQQGDAVAAQGDITLSSTRRGNTLGPLSPDYQDSVLGIDSPSGGDQQHQRGPILEWQRYSELHRPVHEVQQGTLDYHPELKLRASEATLDNPDGDEELALMNVPEENVIPTFLAMAAKETEPFEPKTMLEEVNSLHQNQTWELVDPPKDRRLLSGKWVFKLKRGPHGEIIRHKSRWVVRGFTQEEGIDYEETFASVVKPMSYKALFAIGAALDLEIEQMDVKTAFLYGNIDHEIYVEQPHHMTDGTPRVCKLRKALYGLKQAPRIWYQTLTNFLRSLGFEPITADLGIFVRSSVYIAIYVDDLLIVGPSIAEIKRIKRSLRNRFQMTDLGPCSYYLGVSIQRDRQNRRLLLSQEAYIDNIAHQFGIDNCAPVSTPIETSPLPENSPDYTCSPDQRTSYQRIVGSLMYIMLGTRGDIAYAVSVASRSLSNPGPQHMKLARRILRYLKGTKNLRLTYQGQLQTLRGFTDADWGGCRATRRSTAGYLFKIGSGAISWQSKRQGVVALSTCEAEFLGQTQATKEAVWLRRLLNELNMDQGTTATIICGDNQGAIALASNPQYHSRTKHMEIQRKWQGEVQDNGTVKLKYIPTTEQIADGFTKPLARERFEWFRKGLGIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>W6QB73</accession>
    <name>W6QB73_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Serine hydroxymethyltransferase</fullName>
            <ecNumber evidence="13">2.1.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PROQFM164_S01g000766</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 13">Interconversion of serine and glycine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine</text>
            <dbReference type="Rhea" id="RHEA:15481"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 12 13">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5 13">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 13">Belongs to the SHMT family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.1" evidence="13"/>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QB73"/>
    <dbReference type="STRING" id="1365484.W6QB73"/>
    <dbReference type="OMA" id="TQPFFSQ"/>
    <dbReference type="OrthoDB" id="10265628at2759"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004372">
        <property type="term" value="F:glycine hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019264">
        <property type="term" value="P:glycine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00378">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000097">
        <property type="entry name" value="Serine hydroxymethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00051">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001085">
        <property type="entry name" value="Ser_HO-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049943">
        <property type="entry name" value="Ser_HO-MeTrfase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019798">
        <property type="entry name" value="Ser_HO-MeTrfase_PLP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039429">
        <property type="entry name" value="SHMT-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000586">
        <property type="entry name" value="PRK00011.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680">
        <property type="entry name" value="SERINE HYDROXYMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680:SF57">
        <property type="entry name" value="SERINE HYDROXYMETHYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00464">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000412">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00096">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 13" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="9 12 13" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 13 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Serine hydroxymethyltransferase-like" evidence="14">
        <location>
            <begin position="57"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="12">
        <location>
            <position position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00006376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000412-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CDM26957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="528" mass="57431" checksum="85FAD7C25F5A6701" modified="2014-04-16" version="1">MYLSRCGRSAARLLPLGSSRAAVVSARASIVPRLAPQSRGVASSTRDSQHKLLAASLEESDPTVYNILQQEKNRQKHFINLIPSENFTSQAVLDALGSIMQNKYSEGYPGARYYGGNEFIDASERLCQQRALETFRLNPEEWGVNVQPLSGSPANLMAYSALLNTHDRLMGLDLPHGGHLSHGYQTPTKKISAISKYFETFPYRLDESTGLIDYDALEKSATLYRPKLIIAGTSAYSRLIDYSRMRAIADSVGAYLLSDMAHISGLVAADVLPSPFPYSDVVTTTTHKSLRGPRGAMIFYRKGVRSTDKKGNPIMYDLENPINASVFPGHQGGPHNHTITALAVALKQAQTPDFKAYQQTVLLNASALADRLGDSTSNGGLGYNIVSGGTDNHLVLLDLKNRGVDGARVERVLELCGVASNKNTVPGDKSALKPGGLRLGTPAMTSRGFQPEDFTRVADIVDRAVTITQKLDKAARESAQSRGVKNPNTVKAFLEYVGGGEEISEIVVLRQEVEDWVGTFSLPWADDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W6QB77</accession>
    <name>W6QB77_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sodium:neurotransmitter symporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PROQFM164_S03g000444</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QB77"/>
    <dbReference type="STRING" id="1365484.W6QB77"/>
    <dbReference type="OMA" id="FNNINHR"/>
    <dbReference type="OrthoDB" id="6581954at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035725">
        <property type="term" value="P:sodium ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11554">
        <property type="entry name" value="SLC6sbd_u2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037272">
        <property type="entry name" value="SNS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616:SF240">
        <property type="entry name" value="BLOATED TUBULES, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616">
        <property type="entry name" value="SODIUM/CHLORIDE DEPENDENT TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00209">
        <property type="entry name" value="SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00176">
        <property type="entry name" value="NANEUSMPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161070">
        <property type="entry name" value="SNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50267">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="106"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="178"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="213"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="295"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="353"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="393"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="422"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="457"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="484"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="556"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="586"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="651"/>
            <end position="672"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM33720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="672" mass="74162" checksum="0974181F2A47430B" modified="2014-04-16" version="1">MVLAQYLKKVVAWIAPPPQKSEDGRDQWPSRAAFLLAAMGGCAGQGNLLRYPSVVYNNYGLQWFIPYLLAVFAIAIPALILEIAIGQAYRGGTMIAFNNINHRLKGVGMGPILVSFVVVQYFTVNLAWIMNYFRNSFRSPLPWEGRIEEFYMGDVVANVDPAVGNLTAGNGAVAHYTVYPGIALIGETVGWSAFIWFLIWISIFRGVGLTGRVVYWTMGLPIVTTIIIVGRSCSLENAGEGIRLLWATWRSDQLASGTVWQTAVGQVFFSTGIGFGYFTSYASYNSKHSNAVMDAFLICGSNILFENFAAFAVFGVIGYLRRWPQDGERLGAFVVGFLTLPEAVLHMPGANWWAILLFFTLVVLGFSSAFVMLDAVATLAVDSGMKMSRPMIVTSLTIISFLMSLPYCTQFGFYLLDGIDRWINNVALIFVVWSELVGATTVYRWHDVVSQTGLPAFVVYNFGYFGGQIVGVAVAHGISNPSAGAGAGFGLYIVCSILSVLVATTPAIKAASFWGRNPLLARFWYLAFYSGNQLRRDLNGVVGGNGNWNIPRFWPILLRYVSAPILAIVFSFAYPEFYTLRYDPMMIAGFILAHFCLLLTLLGVVFPRYYDVFIPPHRRAEGTEIMTANQPKEHDFVPDVGVFDFESGMPESISGRKSSDKLDSVHSTLPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W6QBG5</accession>
    <name>W6QBG5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S03</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S03g000090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QBG5"/>
    <dbReference type="OrthoDB" id="4732339at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM33366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="72" mass="8264" checksum="AC62C2E151C9C82A" modified="2014-04-16" version="1">MVNACPTFLAKHPAYLRYVREVASGELVMPKYERDEDDRVIIQVGAQYCRYPGCRVSNVREPDPKCVTHACF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W6QBZ8</accession>
    <name>W6QBZ8_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein ARV</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PROQFM164_S02g001825</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Mediator of sterol homeostasis involved in sterol uptake, trafficking and distribution into membranes.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Regulates also the sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Endoplasmic reticulum membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Golgi apparatus membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the ARV1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QBZ8"/>
    <dbReference type="STRING" id="1365484.W6QBZ8"/>
    <dbReference type="OMA" id="WAVERCF"/>
    <dbReference type="OrthoDB" id="2192830at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032366">
        <property type="term" value="P:intracellular sterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097036">
        <property type="term" value="P:regulation of plasma membrane sterol distribution"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006665">
        <property type="term" value="P:sphingolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016125">
        <property type="term" value="P:sterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007290">
        <property type="entry name" value="Arv1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14467">
        <property type="entry name" value="ARV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14467:SF0">
        <property type="entry name" value="PROTEIN ARV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04161">
        <property type="entry name" value="Arv1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 10" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="154"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="154"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="200"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="220"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU368065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDM31674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="446" mass="47232" checksum="ED683EFBAD7DE4EE" modified="2014-04-16" version="1">MPICIECSYPVSHLYSAYSRADDRSQGKGVRLTQCPRCQRFADKYVEYDFVVLFIDLVLIKPQVYRHLLFNRLGRDDNKFNRSIIRLGVLLLLFDVYLTWARIEKDPSLATTFLSRAPIIVQYLFFLSLNAAATLAHHLTVRLLASMLVPKSRQYSGPDSSNANTNPSTKSTGDATPSAPPTPTTHPSPSGVSIHPHAQNSANPPASLLNPNPTPTPSSYSEVTSPTDLSPLPQGTSMGPSPLPAPPLRRASTAPLQNIQPLPPPTAASPAAISTALLVSSCAKLFPILLVIWGADGSGNLSDIPAHSHTAAQIRSATQSAMVSSAVHQSLFATATETSSLCATAAMSSPPSAAVSSSSFLESWLGVTASSLRTSTPTSYLTGLFDLLASLLSLGVVDAHLVLLSNIEALYILLGCGYLRAVAVAVAGQIARWAVQRVILGAVGVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W6QC63</accession>
    <name>W6QC63_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Genomic scaffold, ProqFM164S03</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S03g000400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QC63"/>
    <dbReference type="STRING" id="1365484.W6QC63"/>
    <dbReference type="OMA" id="TINPICT"/>
    <dbReference type="OrthoDB" id="18529at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037507">
        <property type="entry name" value="Ribosomal_mL59"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040922">
        <property type="entry name" value="Ribosomal_mL59_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28041">
        <property type="entry name" value="54S RIBOSOMAL PROTEIN L25, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28041:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18126">
        <property type="entry name" value="Mitoc_mL59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Large ribosomal subunit protein mL59" evidence="2">
        <location>
            <begin position="16"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM33676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="300" mass="33130" checksum="F3D43BE23090CD50" modified="2014-04-16" version="1">MSVSKQTGTLLENLPQRLVNFFARYPPQTHSAAVRRPAPANGEGYVPMKVESPYTPDRDAKGAPGEKKHGWTPSRALLVTSNDVRNPFLPHKRFGKWEAPKYGLRQQADLMKLAIKYNVGALLPPSRKSPEFKETRRAERGLQVKGTGVGHKVKGHKWERTMESRLEDRRKAMEAMPEMVRMWKQVMAAAGDNGPSGNVDAPPPSTVASSSFPSLFWPVCSFWLFNALSIPTRTGSAQILVPAIAGAWDGVLSLKYTINPICTIQSTVTSPNGTQENHLHESGRCYLSSSSTPIRKLLAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W6QCB4</accession>
    <name>W6QCB4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Src homology-3 domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PROQFM164_S03g000844</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QCB4"/>
    <dbReference type="STRING" id="1365484.W6QCB4"/>
    <dbReference type="OMA" id="MTRPHII"/>
    <dbReference type="OrthoDB" id="196165at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015630">
        <property type="term" value="C:microtubule cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030950">
        <property type="term" value="P:establishment or maintenance of actin cytoskeleton polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000035">
        <property type="entry name" value="SH3 domain containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053039">
        <property type="entry name" value="Polarity_Bud-Selection_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47775">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47775:SF1">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="121"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="200"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="232"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="365"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="44"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="74"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="209"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="234"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="288"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="325"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="369"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="388"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="427"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="439"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="450"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="493"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="555"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="650"/>
            <end position="660"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDM34120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="736" mass="82272" checksum="BE7720058FA55DEB" modified="2014-04-16" version="1">MIRADTLDLQDHDTPSAKDHTKQPEQPDPLGSGRPAPNQGLAIRHAEQDSQAELKDGSHKNQEYRSDKEAYREADDEEDDEDENHYENEDGDLADGESDDMMDDDMMDKISSSPSIDDEDIDFEFVYALHNFVATVDGQANAAKGDTMVLLDDSNSYWWLVRVVKDGSIGYLPAEHIETPTERLARLNKHRNVDLSATMLGDNNEKSKNPLKKAMRRRNAKTVNFGAPTYIDASDVDYSTDDDSEHGDFFNDDETLDGEEEDVQEQAEDIVVEPLRPKAQKENQNPTEHVDANGVEKQDLQRSNSDRRPSSEEFFEAEAEAPVSRSRNGTVRNTDSFFKDDTAEPKKISLTPNLLRDIRDENSTNTLAEWKEPRGSLESIEKGSNSQDKTKDKEEKKRKDKKPGMLSGLFKRKKSKDDIDDLERSPESASRTSPQPKTSMDSVSSKSMSPEQQRPSKPQKFSNNKLHKQPRGIMKVDPVLDPTMAEFARGNEAINQSQGNKSIRQVSQEERESSYEDCEIVLQSPISQSSFSKDPFATPLESMDPMESPVDRPSSESQWRGPNDPSRTTAGPASAQKFVPTLVAGDESESPVNISPVEVYSPMSARGSTSNVSPRDVRSRSPPSPPSSPGQDVNYPKGGTATPALVDTLSVDTPTWSDSSLRSYMDEENDIRDLFIIVHDKSNVPPAGPDHPITGRLFKEESKRLKEMNNQLDEMLVNWMSQRSNSSTRGIRSPQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>W6QCK2</accession>
    <name>W6QCK2_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribosomal RNA-processing protein 43</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PROQFM164_S01g001141</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase PH family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QCK2"/>
    <dbReference type="STRING" id="1365484.W6QCK2"/>
    <dbReference type="OMA" id="EIKAFWV"/>
    <dbReference type="OrthoDB" id="45882at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035925">
        <property type="term" value="F:mRNA 3'-UTR AU-rich region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034473">
        <property type="term" value="P:U1 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034476">
        <property type="term" value="P:U5 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.70:FF:000025">
        <property type="entry name" value="Exosome complex component rrp43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050590">
        <property type="entry name" value="Exosome_comp_Rrp42_subfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097:SF9">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097">
        <property type="entry name" value="EXOSOME COMPLEX EXONUCLEASE RIBOSOMAL RNA PROCESSING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="Ribonuclease PH domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0271">Exosome</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="11" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="10">
        <location>
            <begin position="55"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDM27332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="387" mass="41918" checksum="1D59A5497B2D7894" modified="2014-04-16" version="1">MASSTTASNLTPPSLSLPPSQFARLQPHAYLLAHLSPPPASNQPSIRANGRAASQFRVTSANAGSLTHTNGSAVVRIGDTAAVCGVRAEILHTKDIASWSVLQASSEHNLDNSNYAGVSESQDEEDRGHIQDLNLLVPNLSLSTGCAPGFTPGAPPSALAQSLSHQLLSLLHTTRLVRAEDLRIWYQPPNLESEEFGNAGEGMDVDTEESGGPEREIKAFWVLYIDVMIISLAGNPFDAAWASVLAALRDTKLPRAWWDADNETVLCSDDVADARKLSLRGLPVASSFCSFEGDAAAGWRAVVIPSAEEQKQKKSAQRRWILADPDGYEEGLSQERASVVVDKENGKTVIVKMEKHGGWTVDSDDLRQLVDVSAQRWDEMKRILDQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>W6QD01</accession>
    <name>W6QD01_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Armadillo-type fold</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PROQFM164_S01g001293</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">RNA-binding nucleolar protein required for pre-rRNA processing. Involved in production of 18S rRNA and assembly of small ribosomal subunit.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QD01"/>
    <dbReference type="STRING" id="1365484.W6QD01"/>
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</entry>
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                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>W6QEH3</accession>
    <name>W6QEH3_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="1 2">
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            <taxon>Penicillium</taxon>
        </lineage>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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            <authorList>
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                <person name="Dupont J."/>
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                <person name="Abraham A.L."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="9997739at2759"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM32604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="43" mass="5116" checksum="501F43113509D6B0" modified="2014-04-16" version="1">MVLEYHSLMESGIVLFVVGKDRKRFLIHKELDSSFQARFFDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W6QEV2</accession>
    <name>W6QEV2_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S02g002885</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QEV2"/>
    <dbReference type="OMA" id="GHIMVYY"/>
    <dbReference type="OrthoDB" id="4314168at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM32734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="168" mass="19129" checksum="5C27DBE73BD0469C" modified="2014-04-16" version="1">MITVNQHQYSRALNIYATPSNSESTWYRYGHSHNKASLSPTSNSASYQYNPYPVDTESDTNGLASKIDNGNRGHIMVYYKTLLRTIETKVLPDRRDQISDKYYISYMILLVLLFSNTSLTHRITAVENEVERPVGTLIAIIPNIYRPSLDPIAILLYLLAQLQSKQAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W6QFS7</accession>
    <name>W6QFS7_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Nucleotide-binding, alpha-beta plait</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PROQFM164_S04g000554</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QFS7"/>
    <dbReference type="STRING" id="1365484.W6QFS7"/>
    <dbReference type="OMA" id="FIWQRPG"/>
    <dbReference type="OrthoDB" id="10266058at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23139">
        <property type="entry name" value="RNA-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="277"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="235"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="10"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="66"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="89"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM35673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="429" mass="48224" checksum="CD502F72455435AA" modified="2014-04-16" version="1">MNGDTYSSRETGRSRDYFRDERRDRDRGDRPERGAERPADRGAERGAERGTERGAERGDRSDRGERRRSRSPHHGSRREREVNSYSTSRDYRAREREDRYSGRRDDREWDRGDRAERGDRAERGGGDRGGGDRGGGDRGGGDRGGGRRRDFDERPRRDLFDDRRGGRGGGDRGDRGDRERRDRKRSATPPRRKEPTPDLTDVPSVLTRKRRLTQWDMKPPGYENVTAEQAKISGMFPLPGAPRQQPMDPSRMKDFLNPPTGDSDNAALKPSNSRQSKRLFVYNIPSGVSGDAVITFFNLQLNGLNVIHNVDPCISAQVSEDKTFALLEFKDPNDATVALAFDGITMAESGDKGLEVRRPKDYIVPDGSASQPVQPDVVLSEVPDSPNKICISNIPTYINEEAIIMLLKSFGDLKSFVLVKDAATEESRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W6QG68</accession>
    <name>W6QG68_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">sphinganine-1-phosphate aldolase</fullName>
            <ecNumber evidence="14">4.1.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Sphingosine-1-phosphate aldolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">DPL1</name>
        <name evidence="18" type="ORF">PROQFM164_S04g000286</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">FM164</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 16 17">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the group II decarboxylase family. Sphingosine-1-phosphate lyase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.27" evidence="14"/>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QG68"/>
    <dbReference type="STRING" id="1365484.W6QG68"/>
    <dbReference type="OMA" id="FKDHQFT"/>
    <dbReference type="OrthoDB" id="10254570at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008117">
        <property type="term" value="F:sphinganine-1-phosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030149">
        <property type="term" value="P:sphingolipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06450">
        <property type="entry name" value="DOPA_deC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.140.2150:FF:000002">
        <property type="entry name" value="Sphinganine-1-phosphate aldolase Bst1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000020">
        <property type="entry name" value="sphingosine-1-phosphate lyase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050477">
        <property type="entry name" value="GrpII_AminoAcid_Decarb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42735">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42735:SF6">
        <property type="entry name" value="SPHINGOSINE-1-PHOSPHATE LYASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 17 18" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 16 17" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="16">
        <location>
            <position position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00038965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00042568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CDM35405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="572" mass="62480" checksum="6536913572F36959" modified="2014-04-16" version="1">MSSSMLPVALQNKLVGYGRVSSAHLSALNIDLIRNIIFILFILRYTRKTFYSIRGYGIFGSIRNIYISLRLFCYGLFLRVPGVSGQVDKQVSTAITKLESKLVNSGPDVTRYLTLPKEGWSPEQVRAELDKLAGLEHTRWEDGRVSGAVYHGGAELLKLQAEAFGQFGVANPIHPDVFPGVRKMEAEVVAMVLALFNAPLDGAGVTTSGGTESILMACLAARQKAFLERGVTEPEMIIPDTAHAAFIKACNYFKIKLHRVPCPEPEFKVDVHAVRRLINPNTVLLVGSAPNFPHGIVDDIPALSQLATKYKIPLHVDCCLGSFVVAYLKKAGFPSPYEEEGGFDFRQPGVTSISVDTHKYGFAPKGNSVLIYRNKSYRNNQYFIYPDWSGGVYASPSVAGSRPGALIAGCWASLMSVGENGYINSCTDIINAARKFETAVRTDPTISLHMEILGDPIVSVVAFRSKNGAIDIYDIADDLSAKGWHLNALQSPPAIHCAFTIPTAKAVDQLIADLREVIGKELEKAEQRKREGKSYILQRGDTSALYGVAGSIPDKSIVSRLAEGFLDTLYKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W6QGD7</accession>
    <name>W6QGD7_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g002513</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QGD7"/>
    <dbReference type="OMA" id="HPTRELM"/>
    <dbReference type="OrthoDB" id="2135053at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41805">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41805:SF1">
        <property type="entry name" value="RRNA-PROCESSING PROTEIN FYV7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM28702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="207" mass="23498" checksum="837C50395F44A5BD" modified="2014-04-16" version="1">MAPKRTHDGDAAPVSKGEPAIKKRKGFSVGPANLPDGTYRRKTQKIKNDLIHKAKVKKAYAKIKAQELAIAPRKSVYDTTEGDEVETGKDKEEAGEEATTLELHPDRIAMLNEPEGERAPAPKPEWRPRGEGKQRERRQKPSAFTRELEFAEKRRKAEEARQKEREAKQNERGALLRAKRPDQFGKRRLGRESTALLSRVQRMVGQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W6QGR4</accession>
    <name>W6QGR4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g002598</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QGR4"/>
    <dbReference type="STRING" id="1365484.W6QGR4"/>
    <dbReference type="OMA" id="WLELILW"/>
    <dbReference type="OrthoDB" id="5341924at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="424"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="963"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1095"/>
            <end position="1115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="982"/>
            <end position="995"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM28787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="1115" mass="126159" checksum="E70123CD0359DB0D" modified="2014-04-16" version="1">MSRCLRPGRILPFGRRPTASRLPFIPYRSVSPFSRPTWTQYTRKTRNDQREINFPDEVLFLRRYNLIKHPHLRHDQKRHIEEWMPVLRDCIPPKTTKPPDVAQPAGQPRRLRPLRESEHELDRTHALLGCLWDGRIHFEFQLIAHLGFAHHEWSNVQALLNSLIDTYELLAAHMPPKHPSAGLDWNRPYRVRRRDESTSDLVSPITSKVSLSKLTGGTKSSSPWKWSRLEPLPSDNISLDTLTVEPAPRFFGERILAEVLANLGSLVLYATRSRSDDSKHAMSCVYRTLARLHHAGMISDRVYQYPKPDASQIVFRPPGLHFLSGPIMSVLSDAAWHEHEVAVAAAAADAGKLSPFVPYTPGIRELGPEIWLELILWCCVEHGFCRTGTLLVHQMTRLIEWKAESWAPLINDLATVQKTNVSIEQSWRRPGQNEKPPILKGQDKEPFNGLGFRTISSEVVASLRSGLANKAYVGMGDRGYLPEDLTNLSAPLTKLIDPALSTREELRPTNRFTNWHIVRILASGCLKPSSDPVAFEDLLRSQNNVVPPWEGNELSLAQVLDGKTRAQFYDESAAMTGLIEFNLNYYARDKQSGRLFHEYAWLQNISDASKAQHIQRFFERVSQASDEEASLLFDFKSFEPHDISQSSIPQLSCPTFANLLDVATTTHAFDFGQQLLLENDIDGPAIPQRAYGNQALAPSILRFAAATANVELGERVIASLAIPLSVNTIKSLINFSITRKDWKRVVLMLNFLTEHRAKSWGYVNIGVLASAIIRLDATVKHRTSAGTLTPADTEDLNQATDILLRIFRGEWHANTTREKVRNFQLRTLSRMHRVLSLIPGPLPDILKQVEPPKEITGHHKATLIPPATFHEIFAAVVETQGAIVGKQLWDKVCVDWVSPKRQLQSPGGVARLLFSDERANAHGSPGWDADYVNHVRSKATIADLNTVRILARSAVREYAECVKQATDEQPHGRPSKSKTKTDPNNTTSSSPSSSSFIYDRAASYTPSISRKEYPYQLKSGKMPQTELESILDFCLETFLKFGLPEDQVDIEIPGHMRRMQLRKVFSSPTRRPVRMRIKYNRSDPFMRSHWPKELAESLPPAEEPEPKWPYDNPNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W6QGW2</accession>
    <name>W6QGW2_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="9">TVP18/Calcium channel flower</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PROQFM164_S01g002653</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Golgi membrane protein involved in vesicular trafficking.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TVP18 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QGW2"/>
    <dbReference type="STRING" id="1365484.W6QGW2"/>
    <dbReference type="OMA" id="IYAQWLG"/>
    <dbReference type="OrthoDB" id="5591789at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019365">
        <property type="entry name" value="TVP18/Ca-channel_flower"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13314">
        <property type="entry name" value="CALCIUM CHANNEL FLOWER HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13314:SF2">
        <property type="entry name" value="CALCIUM CHANNEL FLOWER HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10233">
        <property type="entry name" value="Cg6151-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01077">
        <property type="entry name" value="Cg6151-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="42"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM28842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="149" mass="16180" checksum="2B1E74905C816FAA" modified="2014-04-16" version="1">MTLAEEFKSRNFSIYGQWTGVLCIILCLALGIANIFSFNVVLIIISVISIASAFVILFIEVPFLLRICPTSSTFDSFIRRFTTNWMRALIYAVLGGVQLISLAERASSLIAGAVFLLIASVFYALAGLTKQEFVGSKTLGGQGVAQMIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>W6QGX2</accession>
    <name>W6QGX2_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">T-complex protein 1 subunit epsilon</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">CCT-epsilon</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">cct5</name>
        <name evidence="11" type="ORF">PROQFM164_S04g000087</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM164</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QGX2"/>
    <dbReference type="STRING" id="1365484.W6QGX2"/>
    <dbReference type="OMA" id="SHPQMPH"/>
    <dbReference type="OrthoDB" id="10248520at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03339">
        <property type="entry name" value="TCP1_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000003">
        <property type="entry name" value="T-complex protein 1 subunit epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000049">
        <property type="entry name" value="T-complex protein 1 subunitTheta, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012718">
        <property type="entry name" value="Chap_CCT_epsi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054827">
        <property type="entry name" value="thermosome_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02343">
        <property type="entry name" value="chap_CCT_epsi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041082">
        <property type="entry name" value="thermosome_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 10" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDM35206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="548" mass="59856" checksum="D068E6A2B056C1DB" modified="2014-04-16" version="1">MAMQLDMSQASILKDEQGRPFIVVRDQGKKKRQHGTEAVKAHIVAAKTVASIVKSSLGPRGLDKILISADGDITVTNDGATILGQMEITNNVAKLLVELSQSQDEEIGDGTTGVVVLAAAMLEQASDLIDKGIHPIRIADGYDQACEIAVAELDRISDEITFSQDDTTNLLKVAKTSLGSKIVSKSHDQFAKIAVDAVLSVADFERKDVDFELIKVDGKVGGSLEDSLLVRGVIIDKDFSHPQMPDEVRNAKLAILTCPFEPPKPKTKHKLDITSVEEFKKLQDYEKEKFTEMIQQLKESGANLVICQWGFDDEANHLLLQNDLPAVRWVGGPEIELIAIATNGRIVPRFEDLTPDKLGTAGIVREISFGTTREKMLVIEECANTRAVTIFVRGSNKMIIDEAKRSLHDALCVVRNLVRDNRVVYGGGAAEIACSIAVEDAAVKSPGIEQYAMRAFADALDAVPLALSENSGLSPIETLASIKSRQVKEKNTRLGVDCMMTGTNDMREHFAIDPLIGKRQQLLLATQLCRMVLKINNVIISGDDQSEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W6QHC4</accession>
    <name>W6QHC4_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain, cyclin-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S05g000051</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QHC4"/>
    <dbReference type="STRING" id="1365484.W6QHC4"/>
    <dbReference type="OMA" id="PYLDEMS"/>
    <dbReference type="OrthoDB" id="3199516at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="436"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="743"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="756"/>
            <end position="776"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM36218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="805" mass="90911" checksum="5ACC69E0E0957ECF" modified="2014-04-16" version="1">MAGASLDWADKPNADFALSSDEEEFVSSPSTASRELEGPAKQNLTLALGKLHLEQEDLNQSSGQDSTPTTPHMEGLIQTPPELEMAKKPLQLLDLPLDILKEIIKEVTHTTDLTSLALTCSSLHFLAIPHMYSRFDIVWPESLNPSTDDYSGVDALSYGLSTLVMGEDVFNQPALFQSDKVKNSCVNCGCNKPHPQPDPDPGDNGDRLRSRRGNHYAQYTRTFSIGNGPLSWVQEYSVTKEVGKMLGTLVALAVARMVNLEAFVWDMPTGVVREIWLALASLADRPGHDCRLERIWVRWHDNSENALRSSSAAATRLFQKYKHVEHPSLSVLPPLKNVTVLDIDEPAYVEELAILIERSRFRLSELRIGIAEKAHMSPWLLCGKDSDGSTNWPRADGVLGILSRRHLDKKQDNAIVSSLEDKSMPSDESINKSLKSTEIAAPLTPNSEEQPPSTTKDKKSPPSSGLSNRSARSQPPPYKSDYEILHLKVLELERVPLSVPTLLPAVDWTGLTTLTIMRCDDHEKLWRALRRKYAPPATPAKRPHDAERRTNASSVEYPLNLKHIRTDTVSPYLILFIKDALAPNTLESVYLHEAPGHESAVHIDAIYKHILRKHRRSLRKVLIDATDRIIGAGYSGIRWHKWMFTHDMVSFVTSGKMPQLKELGIAMHYRDWHFFLQRLPNMPQLHALYLPHIHHSVHRDLKELALQVLDIVSIRPDLKIAYIGLHIKCYQILEARHDDNPLDFDDNPAIEHSPELSEDEDEGDPDDYDTEPDEEQGDSRIRYRLQEILFYDEKVSIFKARHGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W6QHJ5</accession>
    <name>W6QHJ5_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Diphthine--ammonia ligase</fullName>
            <ecNumber evidence="1">6.3.1.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Diphthamide synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Diphthamide synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PROQFM164_S03g000393</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>diphthine-[translation elongation factor 2] + NH4(+) + ATP = diphthamide-[translation elongation factor 2] + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19753"/>
            <dbReference type="Rhea" id="RHEA-COMP:10172"/>
            <dbReference type="Rhea" id="RHEA-COMP:10174"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16692"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:82696"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.1.14"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="6.3.1.14" evidence="1"/>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QHJ5"/>
    <dbReference type="STRING" id="1365484.W6QHJ5"/>
    <dbReference type="OMA" id="HCRLAQS"/>
    <dbReference type="OrthoDB" id="686384at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017178">
        <property type="term" value="F:diphthine-ammonia ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01994">
        <property type="entry name" value="AANH_PF0828-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06155">
        <property type="entry name" value="eu_AANH_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06156">
        <property type="entry name" value="eu_AANH_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1490.10">
        <property type="entry name" value="putative n-type atp pyrophosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="entry name" value="RutC-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002761">
        <property type="entry name" value="Diphthami_syn_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030662">
        <property type="entry name" value="DPH6/MJ0570"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00290">
        <property type="entry name" value="MJ0570_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12196:SF2">
        <property type="entry name" value="DIPHTHINE--AMMONIA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12196">
        <property type="entry name" value="DOMAIN OF UNKNOWN FUNCTION 71 DUF71 -CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01902">
        <property type="entry name" value="Diphthami_syn_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="YjgF-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Diphthamide synthase" evidence="6">
        <location>
            <begin position="113"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00031552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM33669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="763" mass="83323" checksum="66A83E918B8F9F44" modified="2014-04-16" version="1">MSAAQPSAPGLNVIALISGGKDSLYSILHCIRNGHKVVALANLYPEPRNKTASASPNQRKNDEEEDIDSFMYQTIGHSVIPLYETALQIPLYRQPITGGAVDTARIYGTRATTMDETESLVPLLRRIKQAHPEANAVSAGAILSTYQRTRIESVANRLGLIPIAWLWMYPSLPAPTARTADALAIRQAGLLEDMSAARCDARIIKVASGGLDEGFLWENVSGVGSGGRMMRRCLVKAMSRFAAAEDIRGAVLGEGGEYETLALDGPGFLWKQRIEVGSREEKVGDGGVAFVRLRGARCTAKSAWEIGDGIAPSDIRRPGLLDAVFEGVLGSALELFGSLDDSKSRAMTSTARSPDWPVCEPVHRLSGSTWTISNIVAPEAGPGAGQQMKAIAYKVEKVLKSFAHPKSGSRSTDDIVFATVLLNSMTDFGPMNDIYVSLFKKPNPPARVTVACGDRLPSNVKVMVTFVVDLGARERRQALHVQSRSYWAPANIGPYSQALSVPLQNDSRLVYIAGQIPLDPGSMDLARVEGSSSWIENYRLRAVLALQHLWRIGEAMQVNWWLGAVAFLARGDHANTQAQVAWRLWERMHALPDNEDEDDDDGPQLDAWDIKYGRRTEELTDTPVPSLPQFTALVESHTSIPPFLAVQVDELPRGSDIEWQGLGGLCEQVKLDIKGGTSSTTMDSQYKYTNIEIDAGSSDDTLKQILRSVKEAYCRDSSLSQAVLYTTYPVPEASWPVQVVLCRSVWGREGRRLSAGVVLQQFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W6QHL3</accession>
    <name>W6QHL3_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S04</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S04g000362</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QHL3"/>
    <dbReference type="OMA" id="QARSEIH"/>
    <dbReference type="OrthoDB" id="4326229at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM35481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="90" mass="9931" checksum="8F69280537AA6833" modified="2014-04-16" version="1">MAQHGINPELLPIRISARALTPTPNTSHLDLLYSIVEATIQDVQTRSEAHPDLIIITDITTQEGQQLWDVLDEISSRTGSESASIRTLEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W6QHN3</accession>
    <name>W6QHN3_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Nuclear pore complex protein Nup85</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PROQFM164_S01g002934</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Functions as a component of the nuclear pore complex (NPC).</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the nuclear pore complex (NPC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
            <location evidence="1 9">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the nucleoporin Nup85 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QHN3"/>
    <dbReference type="STRING" id="1365484.W6QHN3"/>
    <dbReference type="OMA" id="YKPSPAC"/>
    <dbReference type="OrthoDB" id="5422384at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011502">
        <property type="entry name" value="Nucleoporin_Nup85"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13373">
        <property type="entry name" value="FROUNT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13373:SF21">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07575">
        <property type="entry name" value="Nucleopor_Nup85"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 9" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="7 9" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0811">Translocation</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1084"/>
            <end position="1115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="44"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1087"/>
            <end position="1107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDM29122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="1151" mass="126038" checksum="BBCF9664ECA457B2" modified="2014-04-16" version="1">MSFQVPYESSPPETPEKDSSRSLWSNLSTTPAGPPPSTAGSFIPHSTSNINGGSRINSFSRNDGAFSTNQNSFSRNDFSNSVFTKSGNINTNDSIFGSSFGSTDYAMPKQTKAPSARLRGNSSLRFGVPNGGFGDSLDFGHSNGFASSQMSDFHEEQEDGMEPEAEETIEKEMNMNAQDQSKNFNFLDSAFGNPFGSQPSMGAQRKQIYSNPNDAKRPKLDEHWAHQSPLRKTNLAPKKPSAMPSILHNIATRSRIAPVKEPSEMILKTEDALGKLSDELKAAEFKHVDFDAVLAKVSKELTDNWQTCADESGIDRPYVAHSGIGPGDQASDLAKATFLASLLLQIHHPSREAASTAHINPMRTGAPGMVKAMTRLPVPKPLPQVLLDWLSDNHVSQTKELQALKYVEPNPTASSNFWDIIIASVLRGRLTDAAGVLRSADFNYARSAMEDGLPQPGYRGAQLQNIQRCVNKALQILESCPGTQAEDWEVTGLDWSQYRKRVLSAVTDLEEFAEGEERDESIMPVPENRFQAVNFGLSTFNSNTANKNPISFAQSARMAESRVPWSIYQSLRSIYRIILGDPSAIKAKSQDWVEATIALTAWWDGEDDTGSNMDFGASDNFPDFLRSRGPKNHVRAVDRNMRGAYLDRLELALSHTTSDGSDTADFRPNPLSSVEVGLASVFEGNVQGVLELVQSWSLCVAAAVAEVASLGGWFESASSQKTIPGLSENDLMVLSYGQDNKSPARHLRKDDILRSYAFGLYDRTVIEDEHSSREGWELAIEVLSRMDDANQMKQAVTEIVDKLPLESPEQLDKLVVLCSELELEDQGRRVSERFGDMLTSKSENFGLALVCYARAQSRRKVKSVVDLLISYSLVQSRAYPATTDLDEQLRSLMKEPKACLSSIAQIDEEAARILQFYLSGYATLRRFYEIRDEEFELQEGQRPRYKPLARRRAAAQALAAVIGSAADNIYGGLYDPDRDSAVQVDGLLALLGEACAFVNQPTAILSVSQQFTILSAIEDLETVTPRVYAQCEECFRSTLLEYQSSMRGGLDGPPSPRALLKKSVSNFSASSFAFIGNDMLESARARSGSGSHPPSVGSSGVLVSTPGDKASADRGWDWRAGLPETAKGGDILQMLRLGLARGLSHGAMGSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W6QHY6</accession>
    <name>W6QHY6_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Autophagy-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PROQFM164_S04g000507</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Autophagosome membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Vacuole membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the ATG8 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QHY6"/>
    <dbReference type="SMR" id="W6QHY6"/>
    <dbReference type="STRING" id="1365484.W6QHY6"/>
    <dbReference type="OMA" id="AVYQEHK"/>
    <dbReference type="OrthoDB" id="6738456at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000421">
        <property type="term" value="C:autophagosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043936">
        <property type="term" value="P:asexual sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16128">
        <property type="entry name" value="Ubl_ATG8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000010">
        <property type="entry name" value="Autophagy-related protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004241">
        <property type="entry name" value="Atg8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10969">
        <property type="entry name" value="MICROTUBULE-ASSOCIATED PROTEINS 1A/1B LIGHT CHAIN 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02991">
        <property type="entry name" value="ATG8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0072">Autophagy</keyword>
    <keyword evidence="10" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="9 11" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="5" id="KW-0926">Vacuole</keyword>
    <feature type="lipid moiety-binding region" description="Phosphatidylserine amidated glycine; alternate" evidence="11">
        <location>
            <position position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR604241-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDM35626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="118" mass="13748" checksum="8C78807255E14793" modified="2014-04-16" version="1">MRSKFKDEHPFEKRKAEAERIRQKYADRIPVICEKVEKSDIATIDKKKYLVPADLTVGQFVYVIRKRIKLSPEKAIFIFVDEVLPPTAALMSSIYEEHKDEDGFLYITYSGENTFGDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W6QI24</accession>
    <name>W6QI24_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S04</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S04g000961</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM36080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QI24"/>
    <dbReference type="OMA" id="RQDARKW"/>
    <dbReference type="OrthoDB" id="76567at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM36080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="299" mass="33183" checksum="A90C7F9C4D781BDD" modified="2014-04-16" version="1">MAENPTLMSDLPQGHVVSFSRLRRLRLEALQISKWFEEHTDGNQWIVVLGLSTPVIEALTSDHGGLGGIAFRFQWEGSTGLIKVVPRSEHEVATDKFTEVIRDSYKAMGVPSEGTAWIGSTTYRSGMRKGKEADNGYVPPSRCTHPIGNVGYPTLIIETGVSESLGRLRQDARKWFADSEGDVRMVVLIIVRKNYVSFEQWQLAPNGAPRPLTRNYIRTLQAQTPNIPPLIRQPARLQQPYCAQSVDITPNPVAGMPNFMDGDPMVLPFVAIQDRPPGPGEGDVVIGLQNFNFVTEFLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W6QI64</accession>
    <name>W6QI64_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S05g000341</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QI64"/>
    <dbReference type="STRING" id="1365484.W6QI64"/>
    <dbReference type="OrthoDB" id="4365878at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM36508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="137" mass="15252" checksum="76E7F4D4451267A0" modified="2014-04-16" version="1">MVTNAVTVEGSGRNIREDDCILNCLPEMKSVILGHISGPLAGRESFAGFLNVPLISDALVKTIEVMFEAPKSCVLQLHNDEASANINWLDVVKERNYEAEYKGNGIYHFHMRDRGVIVQLSAFQHNMILSGLPRKLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>W6QIA8</accession>
    <name>W6QIA8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Prefoldin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PROQFM164_S01g003119</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FM164</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">Binds to cdc4 and rlc1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1365484.W6QIA8"/>
    <dbReference type="OMA" id="DVRFLHK"/>
    <dbReference type="OrthoDB" id="6108017at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120104">
        <property type="term" value="C:mitotic actomyosin contractile ring, proximal layer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903475">
        <property type="term" value="P:mitotic actomyosin contractile ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902404">
        <property type="term" value="P:mitotic actomyosin contractile ring contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01377">
        <property type="entry name" value="MYSc_class_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.820:FF:000001">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.530:FF:000001">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.720:FF:000001">
        <property type="entry name" value="Myosin heavy chain, muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000101">
        <property type="entry name" value="Slow myosin heavy chain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1590">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.360">
        <property type="entry name" value="Myosin S1 fragment, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.270.10">
        <property type="entry name" value="Myosin, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055914">
        <property type="entry name" value="DUF7491"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008989">
        <property type="entry name" value="Myosin_S1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004009">
        <property type="entry name" value="SH3_Myosin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140:SF857">
        <property type="entry name" value="MYOSIN-11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24319">
        <property type="entry name" value="DUF7491"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02736">
        <property type="entry name" value="Myosin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90257">
        <property type="entry name" value="Myosin rod fragments"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51844">
        <property type="entry name" value="SH3_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 9" id="KW-0505">Motor protein</keyword>
    <keyword evidence="5 9" id="KW-0518">Myosin</keyword>
    <keyword evidence="2 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myosin N-terminal SH3-like" evidence="13">
        <location>
            <begin position="110"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="Myosin motor" evidence="12">
        <location>
            <begin position="164"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="50"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="9">
        <location>
            <begin position="737"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1457"/>
            <end position="1477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="2257"/>
            <end position="2279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="2367"/>
            <end position="2398"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="936"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="1009"/>
            <end position="1261"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="1308"/>
            <end position="1431"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="1608"/>
            <end position="1642"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="1717"/>
            <end position="1785"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="1948"/>
            <end position="2039"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="2082"/>
            <end position="2179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="54"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="73"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1465"/>
            <end position="1477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="2385"/>
            <end position="2398"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="257"/>
            <end position="264"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00064372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDM29307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="2398" mass="276029" checksum="476268CF553196B6" modified="2014-04-16" version="1">MLPSQLNGSPKRASLFARPSSSQGTHSPHTRPKSAIITPSNALESARGHLRNTSVSQLSPSLSLSGNRERSNSAKNSPSSGTFAPSFIKSEELRRGADQIRGLEGDNDFSGNKYVWIRDPQKAFVRGLVLEEFEGGRLLVQTDDGDQQELDADQVDKVNPAKFDKADDMAELTHLNEASVVHNLHTRYQSDLIYTYSGLFLVTINPYCPLPIYTNEYIKMYKGRGREETRPHIFAMADEAFRNLVEEGQNQSILVTGESGAGKTENTKKVIQYLAAVATSDTPYGRSGAKQLTGLSQQILRANPILEAFGNAQTVRNHNSSRFGKFIRIEFSRAGQISGALIDWYLLEKSRVVKPNPNERNYHVFYQLLQGADRETREKLLLADLQIEDFAYTRDGNDSIVGVSDQEEWNSLIEAFHVMNFDDEDQLCILRTIAAVLHLGNVSVAKASMRADQATLAPEGYSSMEKACYLLGIEAEAFVKGLLHPRVKAGREWVEKVQTPDQVRMALDALSKGIYERGFGNLVARINGQLGRSMASDDNYFIGVLDIAGFEIFDNNSFEQLCINYTNEKLQQFFNHHMFVLEQEEYAREQIEWQFIDFGKDLQPTIDLIELTNPIGIFSCLDEDCVMPKATDKSFTEKLHSLWDRKTPKYHASRLNQGFILTHYAAEVEYNTSDWLEKNKDPLNDNITRLLAASKAPHVANLFSDCADSEEDGGNHPRSRVKKGLFRTVAQRHKEQLSSLMAQLHLTHPHFVRCILPNHKKRPKMLHAPLVLDQLRCNGVLEGIRIARTGFPNRLPFTEFRQRYEVLCQDMPKGYLEGQTIARTMLAKLGMDRGWYRVGRTKVFFRAGVLADLEEKRDQLIRTIMSKFQSLARGFVQRRISNKRLYRAEATRIIQQNFHAYLDLKGSPWWRMFSRMKPLLGDTRNAKEVKKRDDKIQQLEIKMKQDLAERNKLDEERRRTEIEIQKIQHTLESERALALDKEEIFKRLQYREVELADKLSGAIADQEGLEEQLDELVFAKRKIDDELQLRITQLEQAGLIIQQLESEKNSLHSRVKELDIKLSETEAQFSGKDLQIQELGQEIKILQSHLSLKDRKLQDLEAKLLKTDQDLDIKLANTSKELDKSKKQIRDVTEENRSIRDQIAELSSTSTSYEELLRRKESEIAVLRNDVQIHEEEKRSIESEKISLAARHDNMQSKLREVQAERDAMRSEQRQLQREAADLKNLLENKRSEDAEAGQSRKLLEEQINDLKHHLFQAQADLSRERQSRDDVQMLSEHNLALLTQKYETLNDSKITIEKEMYIQQDSLRRATEARVTAETTKKELQSELIKLRERFTDAETARMNAEAEIERKIMSQAEERMTSSRKDLEEKARQLEEVETERSQLSARIQELMHSISESENFRLRHDQHKERLERELVTLRGRLTASENDNKSLLTKIQQKNLDIARSNSKASDNNRLRLTTLQKEKSRLDEETKRLSRQLEDSQVMIRSLEKQKEKLSLSLEDLNHEVNREHKTSRNAEKAASAANLQLAEANRKLETERQLRNQAQANTRQTQGTLDRANKEIEDLHRQLILLHKVFEPEATEPAQSWEAVQPHLSKKVDLAQVLETVQNRLGVTEEKYARAESQLAEMRRRHGDEMKELDAKYSSSKRALLEEIDQNEVTNNRTPAHLRKNSENAAKKYSNPTTPNRRYNVFEAPNDSARSDRTVDTQAYQRRMDTAAELEELQNKLQMTEMQNKHLQSQLGRSTPTADIWQDESPSIRRMQLLERENGRLHDQLDDSSKKVSSLERSIRSGELSLRDVQAKSHEELYDLINSQEQSRRSLLKVHNETMTEFGDAKAQFEKLKRARATLEVELRDALSEAQELQVGREQDAVSRNQLLQEFSDLQIRLDAESSRSADLESSLMLYKSRSDEYFNKLEQAEIAVMKASRAEQFAKSQGQEAEETCAQIMSERKEMDALVEDLQRQAQSLEARMEDQAAELQGALQAKQRLQNELEDYRNQRAIDLEDKETSMEQTRQKYQREFSTLNNELEMERERVLNGRGETSRLREELENLRSKWDNEVLNSSTWAKEKSRMDVVLQDVTNSRDEAVNAHNEAQSKVVSLLSQVRTLRTSIEDVQAERDMLLKDKKMLEGRLAEAGDRLEDLAKGESPSMRNAASMDRELLELKSRIAQQEDVSAAAVGKMRRADALATEMQKEVTAEREANAQLFKEKAAVEKQLKEAQLRCLDLETKSYSSGSQDVRFLHKRIKELETHLEEQESKHSSEQRSLRNVDRTVKDLQSQIDRRDKVNTQLTDEVNRARDKIERLLRNIEEIQHNDSDAQLLARRAERDLREEREKALRLERELEGWKALRVERGSVIGRGVTFSDTGSRRGSGVYGSNDIPQRQPSNTKGFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W6QJ24</accession>
    <name>W6QJ24_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Zinc finger, LIM-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PROQFM164_S05g000621</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QJ24"/>
    <dbReference type="STRING" id="1365484.W6QJ24"/>
    <dbReference type="OMA" id="CGDPFTP"/>
    <dbReference type="OrthoDB" id="15567at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030695">
        <property type="term" value="F:GTPase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08368">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000077">
        <property type="entry name" value="LIM domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000127">
        <property type="entry name" value="LIM domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000113">
        <property type="entry name" value="LIM domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24216:SF8">
        <property type="entry name" value="PAXILLIN, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24216">
        <property type="entry name" value="PAXILLIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0440">LIM domain</keyword>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="5">
        <location>
            <begin position="559"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="5">
        <location>
            <begin position="638"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="190"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="526"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="72"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="200"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="225"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="288"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="354"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="373"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="403"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="432"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="540"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDM36788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="779" mass="86324" checksum="19EE9D0DF0BC8E69" modified="2014-04-16" version="1">MMHKHPTQRKVSPPGPSFMSNDQVSTYLKDLRANRPARPTGSRPYPGKAAAVSDQSDNLPPRASSAFSMRTPVEHDVEDRRSGSAMSHRRANSQASAGAMGRPLAQEPRTHSIRKNVFPAQIHARTISIPASPALSYRENGQRRHEKEEARALREALQKMDIEDDVGLHQAAQDEATQLVWMHQNPGQAFKNPYAPYQNPDANKGSQSPVKNGSREYDPLTNKFSQSTGSSISSDGNSSPESLRKRSSLAGPSKKNLKVNFKLPELEESVAPEPQTVSSDSFKGILKNPKEQIYEEPIETKKKPEPKKEPEPKSEFSKSDSSAMKNKPRNALGRIPRPLPWLQNRVHSSPMMDKISRFETPKDTPTKPRNAGYTRNESATPSPTQSQVAGYTRNESPTPSPTESHKAGYARNERATPTPPPEEKDELVSIQDGRERRSDEIRAATSKKRGDRSEKLPMPSAVSDRVGRPIVSFDKTWKPVDQPKPDRPTLPVIEIAPPTIEVSEPTPVPVINIPDIKVPTISEIEASSKQAARPHPTGKKPQSQSRWYSPYTRTGVPTASCERCTLSISGKIVTAGGCRFHPECFTCFHCSTPLECVAFYSEPESNRAERLSKTDSSDIEARVPRFYCHLDFHEMFSPRCKSCKTPIEGEVVVACGAEWHVGHFFCAECGDPFDSQTPFVEKDGFAWCLNCHSRRTAPRCLGCKKQVMDDVVVSAIGGQWHESCFNCHECGEGFGSEGRFFVREGEPKRTAKGRIIGGPVQLAICERCEGIRLKAPGMC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W6QJ62</accession>
    <name>W6QJ62_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Signal peptidase subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PROQFM164_S01g003439</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Essential component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Essential for the SPC catalytic activity, possibly by stabilizing and positioning the active center of the complex close to the lumenal surface. Essential for viability.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the SPCS3 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QJ62"/>
    <dbReference type="STRING" id="1365484.W6QJ62"/>
    <dbReference type="OMA" id="WVGALTW"/>
    <dbReference type="OrthoDB" id="10261524at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005787">
        <property type="term" value="C:signal peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045047">
        <property type="term" value="P:protein targeting to ER"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007653">
        <property type="entry name" value="SPC3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12804">
        <property type="entry name" value="MICROSOMAL SIGNAL PEPTIDASE 23 KD SUBUNIT SPC22/23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12804:SF0">
        <property type="entry name" value="SIGNAL PEPTIDASE COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04573">
        <property type="entry name" value="SPC22"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016089">
        <property type="entry name" value="SPC22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="238"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR016089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDM29627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="267" mass="29480" checksum="05F0ADC23464BDBF" modified="2014-04-16" version="1">MHSSLNRIQAVFGFFTTVALVVSALAAVSVLFFPADETNASVQLKNVQVVKGRPHYYSTKREEYAQFRFDLDADLSPLFNWNTKQLFVYVYATYSSSENPDSQVRLSESIIWDTIIPATPSPYSWEILKDKVIALLPAAVLSDSVAAAQRNAKRHAKPPKKAKNKKATGVLRLRGQKGKYQVSDITGRLAERQNVTLHVGWNVQPWVGALFWAPGTGAVPRTAGTIVSSEPFAFPEEKTAAEKRAKEAAEEAEKVKVEKAKAEQASV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W6QJT3</accession>
    <name>W6QJT3_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Thioesterase superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S01g003635</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioesterase PaaI family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QJT3"/>
    <dbReference type="STRING" id="1365484.W6QJT3"/>
    <dbReference type="OrthoDB" id="46529at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039298">
        <property type="entry name" value="ACOT13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21660:SF11">
        <property type="entry name" value="FAMILY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G04355)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21660">
        <property type="entry name" value="THIOESTERASE SUPERFAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioesterase" evidence="2">
        <location>
            <begin position="2"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM29822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="83" mass="8848" checksum="4EC0F9F1BD8F36FF" modified="2014-04-16" version="1">MAIATHGYERTGASIDIHVSYLSTATVGDTLDISAVADRVGKSMAFTTVKISRVVDDEVGPLVSKGSHTKFLPVSKENREPKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W6QK42</accession>
    <name>W6QK42_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S02g000096</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM29947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QK42"/>
    <dbReference type="STRING" id="1365484.W6QK42"/>
    <dbReference type="OMA" id="ENCNSCH"/>
    <dbReference type="OrthoDB" id="3672617at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004882110" evidence="1">
        <location>
            <begin position="20"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM29947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="113" mass="12020" checksum="1242F524764D4CFC" modified="2014-04-16" version="1">MQLIAYLIGAVAPAMLAMAYNDNCDGSLIPANKDDCLKAISNVDTSATYNDGSQFSEGECYLVYATNGSGDQPVSGQKIHDVAQAIVDNCDMQHGSFGTENCNSCHVTVNYRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W6QKC6</accession>
    <name>W6QKC6_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S05g000284</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QKC6"/>
    <dbReference type="STRING" id="1365484.W6QKC6"/>
    <dbReference type="OrthoDB" id="4364700at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM36451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="292" mass="32920" checksum="BF7D2A1A3F736C9C" modified="2014-04-16" version="1">MMTVAESLDIVAVQGCPCFIEFGHGSAMEEEDFLHLKAVWQNVESTNKSQAHIHLRLGAWFNKASQDLDNYPDFNRYLSAVQRRDAPSSRIGMFWAAYEQQCQVAKSLHATSKVKKAYGMNEELVNMSLVNFIQAVCACHPGLDINCNPARVHLTFDFRRVKDEKQAKAIDSNPSLINTLSAIHSCHTPIKPRVEMPPKKTMTVPATVEDWEQAVHPDGTTIVDINASIHDQYKLQSSSAMEEEDFLHLKAVWQNVESTDKSQAHSCENAGLPTLIRVWERTSSFCCWIVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W6QKK4</accession>
    <name>W6QKK4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Aromatic-ring hydroxylase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PROQFM164_S02g000261</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QKK4"/>
    <dbReference type="STRING" id="1365484.W6QKK4"/>
    <dbReference type="OMA" id="RAYEHIQ"/>
    <dbReference type="OrthoDB" id="655030at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46972:SF1">
        <property type="entry name" value="FAD DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46972">
        <property type="entry name" value="MONOOXYGENASE ASQM-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="5">
        <location>
            <begin position="7"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="5">
        <location>
            <begin position="298"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDM30112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="388" mass="42401" checksum="2F7D0DFCBC25E148" modified="2014-04-16" version="1">MTQSQSPIAIVGAGPAGLTLARLLEVAEIPYVVFERDVSATWANEHQSGGTLDLHPTTGQAALLEAGLFPRFQSLARFGVPLTIVDSQGKVHVSHSREGDTEEPEIDRKDLRDLLLSSVPASRILWDHKVQRIERVDNGSVTTHFENQPSRSGFRLVVGADGAWSKIRATVMPSEPQYSGIHFFSSYIKPDNPIYPLAASKAGKGNYLAFGKERQIFLYYLGDGSYHVSVGLRLSEKSIPEGSILASASALWNTVLQEYFAGWDYDLTDFVRSCDGKFRSWPLYTMAEDAIPSWNHVSGVTLVGDAVHLTVPTGDGVNNAMHDSVDLARHIISHGIDNLESATLAYEEAMRPRAVATIQKGHWMTHHMFLAAGPEEMLAAMGADGGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>W6QKL8</accession>
    <name>W6QKL8_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 18">CDP-diacylglycerol--serine O-phosphatidyltransferase</fullName>
            <ecNumber evidence="5 18">2.7.8.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16 18">Phosphatidylserine synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">PROQFM164_S05g000808</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 18">
            <text>a CDP-1,2-diacyl-sn-glycerol + L-serine = a 1,2-diacyl-sn-glycero-3-phospho-L-serine + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16913"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="2.7.8.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="17 18">Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from CDP-diacylglycerol: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 18 19">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.8" evidence="5 18"/>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QKL8"/>
    <dbReference type="STRING" id="1365484.W6QKL8"/>
    <dbReference type="OMA" id="HGCGMIS"/>
    <dbReference type="OrthoDB" id="448573at2759"/>
    <dbReference type="UniPathway" id="UPA00558">
        <property type="reaction ID" value="UER00615"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003882">
        <property type="term" value="F:CDP-diacylglycerol-serine O-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006659">
        <property type="term" value="P:phosphatidylserine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1760:FF:000022">
        <property type="entry name" value="CDP-diacylglycerol--serine O-phosphatidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050324">
        <property type="entry name" value="CDP-alcohol_PTase-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004533">
        <property type="entry name" value="CDP-diaglyc--ser_O-PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016271">
        <property type="entry name" value="CDP-diaglyc--ser_O-PTrfase_fun"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048254">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00473">
        <property type="entry name" value="pssA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269:SF61">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--SERINE O-PHOSPHATIDYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000852">
        <property type="entry name" value="Phosphatidylserine_synth_fun"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 18" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 18" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12 18" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13 18 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="14 18" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="15 18" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 18 19" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 21" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="140"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="214"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00032361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00060701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRNR" id="PIRNR000852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="CDM36975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="240" mass="26309" checksum="0D46EC5D72C1F6BE" modified="2014-04-16" version="1">MSRRTSTMASSNSSSGVPPSGDGGQEKQKMLLSSDHGHFSLVKAMHLADLITEMNGFFMSVFSSMRYCLGDPTEYGSIWAALAFMPFGLFFDFMDGKVARWRKKSSLMGQELDSLADLISFGLAPAAAAFALGIRTSLDHVFLTFFVLCGLTRLARFNVTVAVLPKDQSGKSKYFEGTPIPTTLSIASVMAYWVSQSWTHENIPLGLVAEGTIFEFHPVVLMFVLHGCMMVSKTIHIPKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W6QL25</accession>
    <name>W6QL25_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Meiosis specific protein SPO22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S06g000116</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792020">
        <property type="protein sequence ID" value="CDM37155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QL25"/>
    <dbReference type="OrthoDB" id="65716at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090173">
        <property type="term" value="P:regulation of synaptonemal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039057">
        <property type="entry name" value="Spo22/ZIP4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013940">
        <property type="entry name" value="Spo22/ZIP4/TEX11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40375">
        <property type="entry name" value="SPORULATION-SPECIFIC PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40375:SF2">
        <property type="entry name" value="SPORULATION-SPECIFIC PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08631">
        <property type="entry name" value="SPO22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0469">Meiosis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004879701" description="Meiosis specific protein SPO22" evidence="2">
        <location>
            <begin position="30"/>
            <end position="608"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM37155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="608" mass="69127" checksum="56BF2AEDB4758462" modified="2014-04-16" version="1">MRPLPAGEWTEKCFVAFLLLLSRSDLSDSTRIQALQDVIDSLERRGYPSFSSRASHATLICIWKMTAGAISRNDRWSARLWLQLCSQPKIFQRCSLPIQIVIQKKLVAYYIEAGQLADARWLIDRGIVQSQEDCQRMYLSYKLTLLEGKSGAAHFYLGFPSHPVPHKQLSLLSCAMEAQRQHKPEEVLNCLEPFINCLTSDDIYHHDFPAAEHHMFAITLLSEELSKGGFNQRLGKCIETVLESALSYAKENSLFEGGDREVSVTQLEWLYLATYNVALKLINSSGFLSATHALDHSRDFALQYRQIEYPEGGSKAPRPHLFSVIYLRLLVSTLRARCADPTAKKPHYEDVCICFQQLGDLRGWEDGEETDAGANYKEEKHYNIARFFNLEATMHLNRWQDVVRICASDDTIPDSKFYPQIMDLTLRLNLPPTWAIWLIKRIVSKLNELRDDPPTTWQHEFRASLPRYLHCLFILAIEPDPYASTDRSANLGFKMADAEVAEEVLDKILAMADEEAAVAEERYGTQHSLNAIQVGSEMDYMFTYPAGELINVATMSFNKAIDFYRATRDQDCQRWAEKAIRVAQLVPGAQGKALVNVLQIRLGSLIGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>W6QLB1</accession>
    <name>W6QLB1_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Probable aspartic-type endopeptidase OPSB</fullName>
            <ecNumber evidence="6">3.4.23.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Probable aspartic-type endopeptidase opsB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="primary">opsB</name>
        <name evidence="24" type="ORF">PROQFM164_S06g000595</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Secreted aspartic endopeptidase that allows assimilation of proteinaceous substrates. The scissile peptide bond is attacked by a nucleophilic water molecule activated by two aspartic residues in the active site. Shows a broad primary substrate specificity. Favors hydrophobic residues at the P1 and P1' positions, but can also activate trypsinogen and hydrolyze the B chain of insulin between positions 'Gly-20' and 'Glu-21'.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of proteins with broad specificity similar to that of pepsin A, preferring hydrophobic residues at P1 and P1', but also cleaving 20-Gly-|-Glu-21 in the B chain of insulin. Clots milk, and activates trypsinogen.</text>
            <dbReference type="EC" id="3.4.23.20"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 21">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.23.20" evidence="6"/>
    <dbReference type="EMBL" id="HG792020">
        <property type="protein sequence ID" value="CDM37633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QLB1"/>
    <dbReference type="SMR" id="W6QLB1"/>
    <dbReference type="STRING" id="1365484.W6QLB1"/>
    <dbReference type="OMA" id="CNVTLGT"/>
    <dbReference type="OrthoDB" id="771136at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05474">
        <property type="entry name" value="SAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000011">
        <property type="entry name" value="Aspartic protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000068">
        <property type="entry name" value="Aspartic-type endopeptidase (OpsB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033876">
        <property type="entry name" value="SAP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF65">
        <property type="entry name" value="ASPARTIC-TYPE ENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 21" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="20" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="12 21" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="16" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 21" id="KW-0645">Protease</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 22" id="KW-0732">Signal</keyword>
    <keyword evidence="14" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="22">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004881743" description="Probable aspartic-type endopeptidase OPSB" evidence="22">
        <location>
            <begin position="19"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="23">
        <location>
            <begin position="66"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="active site" evidence="19">
        <location>
            <position position="84"/>
        </location>
    </feature>
    <feature type="active site" evidence="19">
        <location>
            <position position="282"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="20">
        <location>
            <begin position="317"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00067536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00068059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="CDM37633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="481" mass="50413" checksum="B35E16A52C93C20C" modified="2014-04-16" version="1">MKNAWVLLVTGLALPVWGLTLHRRDNPAVVQMDIQRKDILDPVARDQARRKRSTVSQALDNEETLYFCNITLGTPEQSVRLVLDTGSSDLWCNTPNSTLCAASKDACAESGTYNSSSSSSYSFVNSDFNITYADGSGAAGDYVTDTLTIGGTTIKDFQFGLGFTSGSSEGVLGIGYTTNEVQVGRNGDSAYANLPKAMVSKGVIQSNAYSLWLNDLDASTGSILFGGVNTKKYHGTLQTVPVQKVNGQYSEFIIALTGLSLTNSSGKNTYSSSALPAGVLLDSGSSLTYLPDALVQDIYNDLSVSYESDSGIGYVECSMADKNITLGYTFSSPTISVEIKEMIIDVGDLYFRNGKRACVFGIVPAGTSTAVLGDTFLRSAYVVYDLANNEISLANTNFNTTENDVLEIGTGTDSVPGATAVSNPVTTASVGGTAARIGAPQGETGLSGTSSVTGNMAIPMATAMPKHMAVGLVGVGALLAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W6QLY9</accession>
    <name>W6QLY9_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">rRNA methyltransferase 1, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PROQFM164_S05g000834</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM37001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QLY9"/>
    <dbReference type="STRING" id="1365484.W6QLY9"/>
    <dbReference type="OMA" id="HNGCILE"/>
    <dbReference type="OrthoDB" id="270651at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016435">
        <property type="term" value="F:rRNA (guanine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18105">
        <property type="entry name" value="SpoU-like_MRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000035">
        <property type="entry name" value="TrmH family RNA methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047182">
        <property type="entry name" value="MRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047261">
        <property type="entry name" value="MRM1_MeTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013123">
        <property type="entry name" value="SpoU_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46103">
        <property type="entry name" value="RRNA METHYLTRANSFERASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46103:SF1">
        <property type="entry name" value="RRNA METHYLTRANSFERASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08032">
        <property type="entry name" value="SpoU_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00967">
        <property type="entry name" value="SpoU_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="alpha/beta knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="RNA 2-O ribose methyltransferase substrate binding" evidence="11">
        <location>
            <begin position="271"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="38"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="39"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="79"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="97"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="153"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="170"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="188"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="204"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="222"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDM37001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="598" mass="67134" checksum="00714D40150EEBE6" modified="2014-04-16" version="1">MLSTISRTGLDGLSRVIRSSHSTVLAIRHASLNSAIGEGIRRSQTADRDNRRGNDTRFPKREREYEGKYGARQYERSGESNFADRQTNGSRQYGQQKYERSDQTNFNDRRTDGARQYGEQKPERSGFNSGVRRSYGQGEREYGAKKPWTSDGVGRKDYDRRQSPWNEKSQSPRESRKEEKFEFDEDEFIRSGDFRGLPREHQSRFQSRFQSRTQDSPFAQSGRERPWMDEPREKEPVRPRAHRVTRSMPERVKENVKVPDTIPYTTPASEFIYGTSAVEAALRCSRRQLYKLYIYQSTEEELSAAKVTIRKLALSKNIAVKMAFAGWDRLMDKMSAGRPHNGCILEASPLPKLPVRGLLAVPSISEEYFRTELAPQTREEAAVNGTDDRIQIHHPSPSPHEAEQRHRYPIVLLLDGVVDTGNMGAIIRSSYFLGVDAIVLAGRNSAPMSPITIKCSAGAAENMPILHVTNEVDFIQRSQQNGWRFYAADAPLPGSVHMDHISADGDQSGAKLPSTTGPSVIMMGSEATGLSSHIKSHADAIISIPGARQSSILGVESDPARIDSLNVSVAAALLMEKFLRTPMTVGEIAKKEKKEKTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>W6QM12</accession>
    <name>W6QM12_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type DNA-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PROQFM164_S05g000854</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM37021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QM12"/>
    <dbReference type="STRING" id="1365484.W6QM12"/>
    <dbReference type="OMA" id="VWQDCLL"/>
    <dbReference type="OrthoDB" id="1747771at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004507">
        <property type="entry name" value="UbiX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43374">
        <property type="entry name" value="FLAVIN PRENYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43374:SF1">
        <property type="entry name" value="FLAVIN PRENYLTRANSFERASE PAD1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="24"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="64"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM37021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="624" mass="70643" checksum="0F6A81C2AD8FC461" modified="2014-04-16" version="1">MSAVSQSEADRVLHLKSREREAHACYTCRKRKVKCDGNQPCRTCQKRKHPEICTYALAHSRRRSASRHSVARSASPRSPTVASNEQARPDDSSKNYVYSGDNSVVSILRMRASDVNGSVARDVGSVLGLQNTFSNYIFMDSKTPLERWKSLLTVMPQRSEVLKFFHFYRVTAYPFNPILADIDRFESDLCTYLNAHASGEVRDPEKITDRWATDKSIGHISLLLATLAAGAHYSDTEYPERFELSTDFARRSFHALRLANFLFRPSLDIIQALLILGNTLQNMGQSDAAWALLGTTIRLAQTMGLHTERSTVHWPENVRTKARNLWSTIVWQDSLLCLCYDRPPIVSVTGWSPVNSFFERQDLSFAEVMYFICRIGLDTMRPESLSVAEYELAIEGLRQLDYAHQRGLPHLRSRENCTTLQQHLEHLALRMHTSFCVSVLCRPAMKQSTPQPFLHHADILRARAKGSLIDASRAFLDFQALSTVPLRTWSMVHTVLSSTLLLCIWEETRNDPECRNLQQKVIDVFSSSNSGTNDDGASSSESDSQWLSARHIRALVTLRSALDREQETGATETENWAEMTSNMVPQFGPGPMDMPNPFDVSPVTYLDSIMNLPVFDYTQENGFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W6QMC5</accession>
    <name>W6QMC5_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SWR1-complex protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PROQFM164_S08g000064</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SWC5 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792022">
        <property type="protein sequence ID" value="CDM38013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QMC5"/>
    <dbReference type="STRING" id="1365484.W6QMC5"/>
    <dbReference type="OMA" id="FLANRIM"/>
    <dbReference type="OrthoDB" id="445677at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000812">
        <property type="term" value="C:Swr1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011421">
        <property type="entry name" value="BCNT-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027124">
        <property type="entry name" value="Swc5/CFDP1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48407">
        <property type="entry name" value="CRANIOFACIAL DEVELOPMENT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48407:SF1">
        <property type="entry name" value="CRANIOFACIAL DEVELOPMENT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07572">
        <property type="entry name" value="BCNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51279">
        <property type="entry name" value="BCNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BCNT-C" evidence="4">
        <location>
            <begin position="534"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="109"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="286"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="286"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="331"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="342"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="357"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="412"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="450"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDM38013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="614" mass="67974" checksum="6A89A66DD358128C" modified="2014-04-16" version="1">MKEQAVPPTGPAGPGGSTAQRRRQDDWRSRRNPIAPTAPTFLANRIMELMSQAIQRQVDQEGMRPSAARDARVTELTLLAVQAQMVHEFGALHGAANGDQAARGEQLARVRGQGGPLRVRGSRYDRGGSGRGRSRGTYRDTYRDTYRVAHRGAHRGTYRAANRAAHRGVHRGHAVHGTAAGDANQQNLVAREVVPEPVVNAESNWWAAPQTGLEEIEVNGDDIHSCDTAYGRNSSFYLVAPCPKDLDHLSISPVKQKRLTMANATLPENLDLDEEDYDSAEDEDFHLDAAPDDSDLSSDPDEAAEPVKKKRKTDTQSQIPKDAELDSGDEATIRKAREKKDKKAKGKKAKGKHARDSDEDDGDIDLDDNEGGTGGFVRTRAMKQHIQEEQRKPLARIDGATVDVDALWEQMNAPQTHTGLQPPQTQQISESDQEPEPTGETKGQDQGAEDAEHKIGHTVHADQMIKIKRTYKFAGEWITEEKVVPKHSAEAKAFLSSGENVEYTDEDAAAANAARNLRRPLRKISRFDPNPTGTIKKSWEKQLVTDDKDARGPKINTVEKSRLDWASYVDSAGIKDELRTHSKAKEGYIGRMDFLGRVEDKREDERRAARLKGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W6QMD4</accession>
    <name>W6QMD4_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Altered inheritance of mitochondria protein 9, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Found in mitochondrial proteome protein 29</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PROQFM164_S06g000552</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AIM9 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792020">
        <property type="protein sequence ID" value="CDM37590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QMD4"/>
    <dbReference type="OMA" id="FLQAQWP"/>
    <dbReference type="OrthoDB" id="2906425at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051035">
        <property type="entry name" value="Mito_inheritance_9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36091">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36091:SF1">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="7">
        <location>
            <begin position="122"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM37590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="544" mass="61132" checksum="781FDF9B05801B1D" modified="2014-04-16" version="1">MRNAVNSQKCVEATWPARGAPVDNLPSHFLVDEEHQLSRRYVRFNVDALCNTVATAGDSSPVTAIEKMEGGFSKAFLMRKANGTEVIAKIPCRIAGPPSLTTAGEVGVLEYGMMVPIPERVEWLRRTVGRHTSIPVPRVLSWSSDSSNAVGAEYIVMEKAAGVPLYERWRSMTEFERLQLIKNLTKLEAQLSAISFPAYGGLYLRTDMSRPNRSLGDEIDPSKSFCIGPSCDKKFNPDTTLEFDQGPWDSISSLGISITRRELLRISRGQQSRSSFYKGTVEQQTQLLEVTANLMKLLDSNQILTGACQPTLWHTDLHMGNIFVAPDECSRIVSLIDLQSTSILPAFLQAQWPIFLKPPQTYDYVKGIFQPQLPDNFNELDKDSKAIAFREWSQVKLAKAYEVSTYLEDRAAHNAMNVPRVFRELFTRCGEISEVGIVPLRECLIEILQNWSSLGFSGKCPYSFSRDELDAHGRQFAEYRAWHDVQALAEECLDTDAEGWIAPPLDIDEKRRQNGELLDLYIEKVSGEKSAEDAKAMWPFTVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W6QMR4</accession>
    <name>W6QMR4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PROQFM164_S02g001037</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QMR4"/>
    <dbReference type="STRING" id="1365484.W6QMR4"/>
    <dbReference type="OMA" id="IGSHILM"/>
    <dbReference type="OrthoDB" id="3639251at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF58">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04470)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="167"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="201"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="234"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="308"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="352"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="376"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="402"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="434"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="467"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="74"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM30887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="512" mass="56824" checksum="9BA99FB26271622A" modified="2014-04-16" version="1">MVDSEKGQFSFTLTPTAQDLHTLDPVVQETNAQSDGVIFDQAPPEDGQNRLNAERGVEWAALEKRVRWKVDLRLCSIGGLLCSLNLLDSGILSSASVTTMLDDLDLGQGNRFSVSIFIFTIASVIFQLPCTVAVRFVGPRIWFSTITFTFGLLTLCTAFVRNWQQMIILRVLLGIAMSGIYPGLTYLVSAWYPRQEQQLRFAFLQSGEVVILATGNIVNFGLNHLNGVAGLAGWRWMYVVQGLITCVLGIITYWWMVDFPENAQHSFCFLSDQEARLATRRIQDDRADVIPEPFSWGTLLANFKDPKIYGFAIMFFLLNLISTALSYFLPIILQSGMGFSSNKSILLSTPPYYYAIIPVILTSLIGDFYRVRGPLIIFNALVLIAGFLMFGLPVSTRVAVRYIGTFLATGAYISNWAALNAFQANNIVGQWKRVATAAAVTACNGLGGVAGSFIVRQQEAPQYQTAVWVSIGSHILLIAIVGAFTIYFYIVNRQQKRGLKILEGVSGFRYTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W6QN53</accession>
    <name>W6QN53_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NmrA-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S11g000016</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792025">
        <property type="protein sequence ID" value="CDM38313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QN53"/>
    <dbReference type="OrthoDB" id="3358371at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="2">
        <location>
            <begin position="72"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM38313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="122" mass="12947" checksum="E210B4190CAB0AEC" modified="2014-04-16" version="1">MNPENLKPPAPPIMETTVAFSTGSTLSAERNPNSDRAHCGKADTDCRLPPSGAKPVAKPWPKEHEPLATRFSLIVIVRATGGQGGSVVSSFLKAGGWNIRSLTHNTESDKAKALVVKGFEIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>W6QN81</accession>
    <name>W6QN81_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphotransferase</fullName>
            <ecNumber evidence="6">2.7.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PROQFM164_S02g001257</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the hexokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.-" evidence="6"/>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QN81"/>
    <dbReference type="STRING" id="1365484.W6QN81"/>
    <dbReference type="OMA" id="LDMGITF"/>
    <dbReference type="OrthoDB" id="419537at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005536">
        <property type="term" value="F:D-glucose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008865">
        <property type="term" value="F:fructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004340">
        <property type="term" value="F:glucokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019158">
        <property type="term" value="F:mannokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001678">
        <property type="term" value="P:intracellular glucose homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006013">
        <property type="term" value="P:mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd24000">
        <property type="entry name" value="ASKHA_NBD_HK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000211">
        <property type="entry name" value="Phosphotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.367.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001312">
        <property type="entry name" value="Hexokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022673">
        <property type="entry name" value="Hexokinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022672">
        <property type="entry name" value="Hexokinase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443">
        <property type="entry name" value="HEXOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443:SF29">
        <property type="entry name" value="PHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00349">
        <property type="entry name" value="Hexokinase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03727">
        <property type="entry name" value="Hexokinase_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00475">
        <property type="entry name" value="HEXOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51748">
        <property type="entry name" value="HEXOKINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="4 6 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Hexokinase N-terminal" evidence="8">
        <location>
            <begin position="49"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="Hexokinase C-terminal" evidence="9">
        <location>
            <begin position="299"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="Hexokinase C-terminal" evidence="9">
        <location>
            <begin position="526"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="495"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="498"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDM31107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="624" mass="68450" checksum="B4812CE17DCD7F7A" modified="2014-04-16" version="1">MASVNSKSSKKDEDEEHEIMHDDLIEDDEEASSELNAVEQECLAHHQQLEEFLSPLFLDEAVLYKLARRFSTTYRNLALTSDQQFLPTPVTQLPTGRETGRYLAIDVGGSNLRVAFIELLGEAVDSDVRPTDATERSRDTIRKAQRQRVKRTLERAWPIQEHLKMDKAEDLFSWIGDCIAEVVAESLSSDATKKDIPAELDMGITFSFPIMQESLAEATLMPMGKGFAISSNLNLGNILLDGYEKHTRRPDDEDEPSTKRRKLFALPKLKIQAITNDTVATLASLAYKVKSLPNSRVAMGIIVGTGCNATIPMKLSALHESKAKSVNIMEPSAVETVVNTEWTISGAAPPLKELNVTTKWDIELDQACSRPGFQPFEYMTGGRYIGELIRLIIFDYLTTVAKLSKRSLPANLIQEYALTTTYISDVVAKARSDNDLAKALNKSLPPPECSDWRWDARAAGAFRKIARTVQRRSAGLIAAAVVGLLACAREIELKEDSNSSSPENPASPQIHGDTITESLSAPDAAAASLNSAAVAASHAAQEHVVPVLDPTPIDWQSGPEELVVAYTGGIIQHYPQFKEMCQQYIDRLIMRTGPQRGGKSVFLREASDGGVIGAGVLAGMVVRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W6QNW3</accession>
    <name>W6QNW3_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S04</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S04g000650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QNW3"/>
    <dbReference type="STRING" id="1365484.W6QNW3"/>
    <dbReference type="OMA" id="FEAQFKP"/>
    <dbReference type="OrthoDB" id="5556956at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027973">
        <property type="entry name" value="FSAF1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053030">
        <property type="entry name" value="Ribosomal_biogenesis_FAF1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28096">
        <property type="entry name" value="PROTEIN FAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28096:SF1">
        <property type="entry name" value="PROTEIN FAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15375">
        <property type="entry name" value="FSAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM35769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="308" mass="33575" checksum="F605D69616FE7C70" modified="2014-04-16" version="1">MVVKRKRETTVVSKPQTKEDSPPPVDNAQDVFRRLFEAQFEPLDLPAPTAKSTEIGNEEDDDSDFSGSEGDWDGVSDISDESNQVEVVEHTDAYAAPEDRMDKKTWKAFMSGKLLSDLDKPSADPEPTSKKEEEEDAHDSANLKHDLALQRLLKESHLLDSANDLAPTGKNRLKALDMRMQSLGAKTSLYAQTKMPTAHRRGIKAKAESKEDRRRQEAKENGIILEKPNKVHKSSNNGRRERGLAGSSVGRFSGGTLNLNKDDIARVQASGRRMMGGRGKGKTRGGRGGGGGRGGRGGGRGGGRGDKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W6QP21</accession>
    <name>W6QP21_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S04</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S04g000710</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QP21"/>
    <dbReference type="OrthoDB" id="3641682at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM35829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="140" mass="14695" checksum="B777169425B8F53E" modified="2014-04-16" version="1">MLNSINAFNELLGVSNLFDSVGFSVSDSQTYSVSNTVTCNGVSAERGDICVLFYQAVTVFTANVKEVNSCACGGGTTIIDRGEAIVYAPNPNQVGSVTGRGINVANHGVQQGEGPWIADYVNLRAPAGCAIPIEANRYQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>W6QP23</accession>
    <name>W6QP23_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Glutamate decarboxylase</fullName>
            <ecNumber evidence="3 9">4.1.1.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">GAD1</name>
        <name evidence="10" type="ORF">PROQFM164_S07g000084</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 9">
            <text>L-glutamate + H(+) = 4-aminobutanoate + CO2</text>
            <dbReference type="Rhea" id="RHEA:17785"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:59888"/>
            <dbReference type="EC" id="4.1.1.15"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7 8">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the group II decarboxylase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.15" evidence="3 9"/>
    <dbReference type="EMBL" id="HG792021">
        <property type="protein sequence ID" value="CDM37736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QP23"/>
    <dbReference type="STRING" id="1365484.W6QP23"/>
    <dbReference type="OMA" id="ECRDKNM"/>
    <dbReference type="OrthoDB" id="5152799at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004351">
        <property type="term" value="F:glutamate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006538">
        <property type="term" value="P:L-glutamate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000017">
        <property type="entry name" value="Glutamate decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.160:FF:000004">
        <property type="entry name" value="Glutamate decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.50:FF:000001">
        <property type="entry name" value="Glutamate decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010107">
        <property type="entry name" value="Glutamate_decarboxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01788">
        <property type="entry name" value="Glu-decarb-GAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43321">
        <property type="entry name" value="GLUTAMATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43321:SF6">
        <property type="entry name" value="GLUTAMATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="5 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 7 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7">
        <location>
            <position position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDM37736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="511" mass="58471" checksum="547988C4D11BAED8" modified="2014-04-16" version="1">MVHLAKVKKDSELPSARQFDSIPPIETNDADTNVYGTHFAVDHMPQHEMPEREMPRQIAARMIKDELSLDGNPKLNLASFVTTYMEEEIEEIMTDSFSKNFIDYEEYPHSAEIQNRCVNMIARLFNIPTDAASENAMGTSTIGSSEAIMLGTLAMKKRWQNKRKAEGKDFSRPNIIMNSAVQVCWEKAARYFDIEEKYVFCTDTRFVIDPQQAVDLVDENTIGICAILGTTYTGEYEDVKAINDLLVERNIDCPIHVDAASGGFVAPFTDPNLVWDFRLEKVVSINVSGHKYGLVYPGVGWVIWRAVEYLPQELVFNINYLGADQASFTLNFSKGASHVIGQYYQFIRLGKHGYRAIMTNLTRISDFMASEFEKLGMVILSQTQGRGLPLVAWRLPTDPNRVYDEFALAHQLRERGWVVPAYTMAPHSEKMKMMRIVIREDFSMNRCDSLIQDFKLAIDTLDAMDKNMMAKYRVHMKNHRNQPRHQSLIHRHYLEEKHSLQGKDGKTHGVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>W6QP88</accession>
    <name>W6QP88_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ubiquitin-conjugating enzyme E2 1</fullName>
            <ecNumber evidence="1">2.3.2.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">E2 ubiquitin-conjugating enzyme 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">ubc1</name>
        <name evidence="11" type="ORF">PROQFM164_S04g000795</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="9">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="1"/>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QP88"/>
    <dbReference type="STRING" id="1365484.W6QP88"/>
    <dbReference type="OMA" id="THLRGQF"/>
    <dbReference type="OrthoDB" id="9993688at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd23800">
        <property type="entry name" value="UBCc_UBE2K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000037">
        <property type="entry name" value="ubiquitin-conjugating enzyme E2 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015368">
        <property type="entry name" value="UBA_C_fun"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09288">
        <property type="entry name" value="UBA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 9" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="10">
        <location>
            <begin position="4"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="8">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00072431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00077197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDM35914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="237" mass="26115" checksum="92ECD238F11D731D" modified="2014-04-16" version="1">MASNRMRRIGKEIADIHADVHSHIKAEPFGNLDDLTHLRGSFPGPPGTPYEGGIYDIDIKIPTDYPFRPPTMKFETKVWHPNVSSQTGAICLDTLSSAWSPVLTIKSALLSLQSLLSTPEPKDPQDAEVANMLLKSPKEFERVARDWAVLYAGAPVRSADNGSGSSLDDTRQAASEDNLAKYDGYNKNLIDRFSSMGFDVDRVVAAFRYVGVERRGGQDYELEEGRMGDIAARLLGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W6QPW3</accession>
    <name>W6QPW3_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S12g000079</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792026">
        <property type="protein sequence ID" value="CDM38470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QPW3"/>
    <dbReference type="OrthoDB" id="4367900at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM38470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="33" mass="3815" checksum="536DACE3F9EAE488" modified="2014-04-16" version="1">MKVLNLNASRAIPVLKLLDLYFCLWECYVVKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W6QPY1</accession>
    <name>W6QPY1_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 15">Long-chain-alcohol oxidase</fullName>
            <ecNumber evidence="7 15">1.1.3.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">PROQFM164_S02g001772</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Long-chain fatty alcohol oxidase involved in the omega-oxidation pathway of lipid degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>a long-chain primary fatty alcohol + O2 = a long-chain fatty aldehyde + H2O2</text>
            <dbReference type="Rhea" id="RHEA:22756"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:17176"/>
            <dbReference type="ChEBI" id="CHEBI:77396"/>
            <dbReference type="EC" id="1.1.3.20"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell envelope</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 15">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.3.20" evidence="7 15"/>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QPY1"/>
    <dbReference type="STRING" id="1365484.W6QPY1"/>
    <dbReference type="OMA" id="RNVKGCW"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046577">
        <property type="term" value="F:long-chain-alcohol oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-dep_OxRdtase_2_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012400">
        <property type="entry name" value="Long_Oxdase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46056">
        <property type="entry name" value="LONG-CHAIN-ALCOHOL OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46056:SF12">
        <property type="entry name" value="LONG-CHAIN-ALCOHOL OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028937">
        <property type="entry name" value="Lg_Ch_AO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0274">FAD</keyword>
    <keyword evidence="9" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="13 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="FAD-dependent oxidoreductase 2 FAD-binding" evidence="18">
        <location>
            <begin position="223"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="17">
        <location>
            <begin position="270"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase C-terminal" evidence="19">
        <location>
            <begin position="589"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="16">
        <location>
            <position position="676"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR028937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR028937-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF05199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CDM31622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="752" mass="81261" checksum="7ACD68BAC4B7D83F" modified="2014-04-16" version="1">MPTLTVSTYTPRDVPLPPAPSATYFSELQWKTFYALADAVVPSIHTAATTKSSNDRVISNAEWNSAVSSLSTAISGPDAVNLATQYLQENVSSNPQFRAAVERLLGDYVNDEGRNGFGFIMSALNTRAGSLVMTGSTTPIQDQPIEFREKILRGWDTSRLAPLRAIYRGLTAIVKKCWVISSPTISPVLGFPSIPIHGEQVDGFQFEFLQFPSGDQPETIETDVVIVGSGCGGSVAAKNLAEAGYRVLVVEKSYSYPTNTFPMGANEGYTNMFENGGAVSSDDGSMAVLAGSTWGGGGTVNWSAALQTQGYVRQQWADTGLPFFTSLDFQKSLDRVCDRMGVNDDHVEHNYQNKVVIEGARKLGYAVKTVPQNTGHGEHYCGYCTLGCASGGKKGPTESFLVDAAQAGAKFIEGFRADKVLFTTVKGKKVASGVQGTWKSRDSYLGLAGIGAVERRLIIKAKKVVVSAGTLQSPLLLLRSGLKNPQIGRNLHLHPVLAASAVFDEDTHPWEGSALTTVVTEFEDLDGNGHGAKIETAAMLPSVVIPIFPWRDSLEYKMWAAKMRHSTSFIVLTKERDTGRVYPDPVDGRCRIDYTVSAFDRKHMVETLIGIAKIAYISGAKEFHTVYRDLPPFIRPETSDPEAPEGINNTALQSWIAELRAKSPLNPERGLFASAHQMGTCRMSKSPKLGVVDPDCQVWGTDGLYVVDASVFPSASGVNPMVTNMGIADWASRNLARAMGTVPGEGNVMARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W6QR94</accession>
    <name>W6QR94_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Iron-sulfur assembly protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PROQFM164_S05g000417</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Involved in the assembly of mitochondrial and cytoplasmic iron-sulfur proteins. Probably involved in the binding of an intermediate of Fe/S cluster assembly.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the HesB/IscA family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QR94"/>
    <dbReference type="STRING" id="1365484.W6QR94"/>
    <dbReference type="OMA" id="FGPRKAT"/>
    <dbReference type="OrthoDB" id="333486at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.300.12:FF:000001">
        <property type="entry name" value="Iron-binding protein IscA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.300.12">
        <property type="entry name" value="HesB-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016092">
        <property type="entry name" value="ATAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000361">
        <property type="entry name" value="ATAP_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050322">
        <property type="entry name" value="Fe-S_cluster_asmbl/transfer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017870">
        <property type="entry name" value="FeS_cluster_insertion_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035903">
        <property type="entry name" value="HesB-like_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00049">
        <property type="entry name" value="iron-sulfur cluster assembly accessory protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10072:SF41">
        <property type="entry name" value="IRON-SULFUR CLUSTER ASSEMBLY 1 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10072">
        <property type="entry name" value="IRON-SULFUR CLUSTER ASSEMBLY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01521">
        <property type="entry name" value="Fe-S_biosyn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89360">
        <property type="entry name" value="HesB-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01152">
        <property type="entry name" value="HESB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core" evidence="5">
        <location>
            <begin position="132"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="51"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="84"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="105"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="119"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00054873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00071673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDM36584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="235" mass="26090" checksum="0FAA02EC40DA982B" modified="2014-04-16" version="1">MSFSTTMQRPVTSSATLLRWVKPSAGRLRTFSSYGNAYLASKRDMQTATAYRPHSLPSSFPPPRSTGGADTSISAEFPSDMKSYRNTSQGTLSNVSLREGEAQKSKPTSASPPASKTSPKPRRPLRPRKAAMKLSTLAIEQLRKLMAQPEPKYIRVGVKNRGCSGLAYHLEYVEKPGKFDEVVEQDGVKVLIDSKALFSIIGSEMDWQEDKLSRRFIFRNPNIKEECGCGESFMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W6QRV0</accession>
    <name>W6QRV0_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S02g002403</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QRV0"/>
    <dbReference type="STRING" id="1365484.W6QRV0"/>
    <dbReference type="OMA" id="YEYWMPA"/>
    <dbReference type="OrthoDB" id="1937642at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="202"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="282"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="306"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="384"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="391"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="410"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM32252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="419" mass="45797" checksum="4C901DDC9034672B" modified="2014-04-16" version="1">MAPFLATLLSREPRFDPTVSSNEFRTQWVHPSDVFSVLLILGGDIVARALAQLAGSGLTPVTFSFGWVAYSVSALVSAVGENKLMPQNVDCKCKVINGKSGYSRDNSSWVIGRIVRDFDTWSGTATKEKTKKLLGEKWEELKSLDKAAEEPTRAGLVVTIYEPSATPKAGLAKRDLIFWSGLLIMLLQLGIAAIPCGLFGDWGILIITACGNVLAIVTGVLPQWKKEKWACRPKSKYSYILTRGNGAQHAIVILGNGHGLNLEDLASGQSNVESSTNTLTRAVLLALSIFWVLLLIAAAGLRGNTWFLLAIGGIGIVQNVFVAGRSMKPENYGIHLDYVGVFGKTKVMDTLLDVEQKYPGIGRSMRDEFFPGKLPLAGVRAWEQIEQSTESEPRAKAPRESQDDSEETQAEERQVEERI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W6QT53</accession>
    <name>W6QT53_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S06g000225</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792020">
        <property type="protein sequence ID" value="CDM37264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QT53"/>
    <dbReference type="OrthoDB" id="4509322at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM37264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="88" mass="9573" checksum="69560121D568AA54" modified="2014-04-16" version="1">MKIEVQLAPQPQLVGLTDPVLVEVQASLHDHRQVSEDFGGLPTLPRPLPGSSTDNPIDVDALSDPDIETRVYPHDLPRAGDSIEPDRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W6QU72</accession>
    <name>W6QU72_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">chitin synthase</fullName>
            <ecNumber evidence="2">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">chsD</name>
        <name evidence="13" type="ORF">PROQFM164_S02g003228</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="2"/>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM33077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QU72"/>
    <dbReference type="STRING" id="1365484.W6QU72"/>
    <dbReference type="OMA" id="DIMGLCG"/>
    <dbReference type="OrthoDB" id="370884at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04190">
        <property type="entry name" value="Chitin_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054295">
        <property type="entry name" value="CHS4-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF16">
        <property type="entry name" value="CHITIN SYNTHASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03142">
        <property type="entry name" value="Chitin_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22997">
        <property type="entry name" value="CHS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="483"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1065"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1090"/>
            <end position="1110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1116"/>
            <end position="1139"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin synthase 4-like" evidence="12">
        <location>
            <begin position="391"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="611"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1184"/>
            <end position="1209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="54"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="67"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="89"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="161"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="177"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="630"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1189"/>
            <end position="1199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF22997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDM33077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="1209" mass="136717" checksum="77912C2A80C96216" modified="2014-04-16" version="1">MFQSASDILPEMSLPQRPGRPSPRREEARAFREPSQRRRRDIDSGTYSDDPTSHSHRHRRRHSSHRRAMDTDEERMDRSGDVRHKKRMVKPERRKDDRDQPNYHYRQRSNHMRIFPSTTGNDPLLDKRDEVETNSSRSMDMKSKGLYARGNINKPMERVPSRHRSKKKKRGSRRSRGVAEEKRREKAIEQSGPPELWPTYCVVLTFFIPDFLLKCCGMPQKEQRTAWREKIGLISIIMMIGAFVGFLTFGFTATVCASPPVRLKVNEVSSNYMIFHGKAYDLSGSKHPAVTGISANANVLYDLPHKYGGQDGSFFFQQVNGACKGLITATSDSDIPTNSDGDLGWYFPCAPFNQDGSSEPNTTVEYYVGWACHTSKAAREPFYTLHSEGDVYYTWEDTKNKSRNLAIYSGNVLDLDLLAWFDTSQVSYPKQFDELRKNPDVRGVDLTYYLQSGEEKKIGKCLAQIIKVGSIDTDTVGCIASKVVLYVSLIFILSIVGVKFAFALLFQWFLAPRFAAQTTSMASDARTRNQQIEDWSNDIYRPAPRMTEPTIPDRLSKRASFLPTTSRFSSPYNVNSSAGSKQKPLYVTMASQNSTSRLMPSSNPGTMYKLSHSGSGGTLSADNSRHNPGASRTSLVPTGQGQQDTGYATLSTDYEGLGPAGYIHEAVVPQPPPEWQPFGYPLAHSLCLITCYSEGEEGIRSTLDSIAMTDYPNSHKTILVICDGIIKGKGESFSTPDIVLGMLREPVVPEDEVEPYSYVAVATGSKRHNMAKVYTGFYDYGHNSIIPADKQQRVPMMVIVKCGTPQESTQSKPGNRGKRDSQIILMSFLQKVMFDERMTELEYEMFNGLWNVTGIAPDFYEVVLMVDADTKVFPDSLTHMVSAMVKDPEIMGLCGETKIANKTDSWVTMIQVFEYFISHHQAKSFESVFGGVTCLPGCFTMYRIKAPKGGQNYWVPILANPDIVEHYSENVVDTLHKKNLLLLGEDRYLTTLMLKTFPKRKQIFVPQAVCKTVVPDAFLVLLSQRRRWINSTVHNLFELVLVRDLCGTFCFSMQFVIFIELIGTLVLPAAISFTVYVVVVSIVKKPVQVIPLVLLALVLGLPGVLIVVTAHRLVYVLWMLIYLLSLPIWNFVLPMYAFWKFDDFSWGDTRKTAGEKDKGHGDAEGEFDSTKITMKRWRDFEKDRRLRSAWSQPPTTDVHPSQYEPYSHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W6QUA3</accession>
    <name>W6QUA3_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Reticulon-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PROQFM164_S07g000057</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Endoplasmic reticulum membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792021">
        <property type="protein sequence ID" value="CDM37709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QUA3"/>
    <dbReference type="STRING" id="1365484.W6QUA3"/>
    <dbReference type="OMA" id="TGLMKQY"/>
    <dbReference type="OrthoDB" id="567788at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003388">
        <property type="entry name" value="Reticulon"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02453">
        <property type="entry name" value="Reticulon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50845">
        <property type="entry name" value="RETICULON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="Reticulon" evidence="8">
        <location>
            <begin position="71"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="40"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="50"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM37709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="352" mass="39464" checksum="C735F52063311272" modified="2014-04-16" version="1">MASGDVTYPNTGSKVREPSIRDVITKGPIVNNVKSEASRTSDEFRDLKNSRVTPSNTTADGQPLTHYHSLMYSLLSWEQPRATAVSYASMICFIFAARYMPLLRWAFKFLYMSLGVTATVEIAGHLILKRGIASGFRPRRYYTVPKEVIEGVLEDLEQLVDFFLIEFQRILFAENVLHTVFAFNAAFIGYWLLRFLPFWGVALIAVTTTYFTPLIYISNREFIDEQITNYQEIINSQTNQLRDMAGERTSHATDLVKQYVGEYSSKAQGYIAHRRSASRETKLASPIKRETVEPAANFTAPVAKPAVEPVIKHEDFPEAPKAAPVAQALESGIVASVEPAEQAKGREPLLAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W6QUJ1</accession>
    <name>W6QUJ1_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type DNA-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PROQFM164_S07g000117</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792021">
        <property type="protein sequence ID" value="CDM37769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QUJ1"/>
    <dbReference type="OrthoDB" id="4685598at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053181">
        <property type="entry name" value="EcdB-like_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47785">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="11"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="72"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="104"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM37769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="286" mass="32037" checksum="306D1995237F20C4" modified="2014-04-16" version="1">METGRKRASLACNYCRRRKRRCNGAIPSCSLCEDSGIDCVYNEADTARPRGETSSSEFFRRLDAIENFLWSHPRLPQTPQTGETRSGDFTLPPSSENERADFSHPSTMLISSPSRPNPADISQLISTNSSTFIPPEHDIPPMSIPIGHTTTTEYMLHMTRVKALFGEFPPDLFIRAESKRHMPHQLSFVPGTITASQLPILNEASTYPLVEAYFKHVHVEMPILDKDQFLGLYDHHIRAGLSVDCDSALCLAVLALGSAALEQVDPIKSKSPYWVGQTSFHLRCRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W6R3Q5</accession>
    <name>W6R3Q5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Isopenicillin N synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PROQFM164_S05g000270</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6R3Q5"/>
    <dbReference type="STRING" id="1365484.W6R3Q5"/>
    <dbReference type="OMA" id="KSDCHLR"/>
    <dbReference type="OrthoDB" id="406156at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.330:FF:000040">
        <property type="entry name" value="Chromosome 21, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00682">
        <property type="entry name" value="IPNSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Non-haem dioxygenase N-terminal" evidence="4">
        <location>
            <begin position="37"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="Isopenicillin N synthase-like Fe(2+) 2OG dioxygenase" evidence="3">
        <location>
            <begin position="199"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDM36437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="370" mass="41744" checksum="4F01B0955CFB07F8" modified="2014-04-16" version="1">MATLTQPPAPVPTGSDIPTYSQVPETTFDLDWADLATLDLSLFDQPGGKEQLAKQLFEAIQNIGFFYITNFGLSQEDVDRQFAIGKEIFKLPIKEKLKYRAELEKGGYNGYKPMGLREISPGVYDKTEIYNIPKFIPALELPQPDIVNNNRPIIEGFARHIHDQIAAKLLTLFAIILELPEDYFLKVHRYDEKSDCHLRYMKYHRRSDEENEKAAGIWSKGHTDFGSLTLLFRQPVAALQVRTPEGEWKWVKPYPGSITVNLADSLHFLTNGFLKSSIHRVVAPPPDQRDVDRLGVLYFVRPEDSLELRPVVSDVLHRLGYDQTTDNSAVGITAGEWVKARVAKGVDKGVARSEIGDQPIIGGVVAKYYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W6R3S7</accession>
    <name>W6R3S7_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S05g000290</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6R3S7"/>
    <dbReference type="STRING" id="1365484.W6R3S7"/>
    <dbReference type="OMA" id="VYMILTE"/>
    <dbReference type="OrthoDB" id="4177740at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM36457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="152" mass="17509" checksum="BB3E41E8BF9DBA39" modified="2014-04-16" version="1">MDYYLTLVDSPGQYNAYKSLYFHGSPSLGPSPTFGAFKIIDSPGKEYPHLKAVIYTDMEADDKTCFRSEVLISLRLMLAQLRKVRLMHHKIAPVLLVSLMGKHVRILESYFDGKLLQMRSTRLYKISDWDSIKTVYMILTEYLLGPPIRDTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>W6PPW8</accession>
    <name>W6PPW8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S01g000032</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PPW8"/>
    <dbReference type="OrthoDB" id="10293823at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM26223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="142" mass="15501" checksum="437B36ECE41FC8E2" modified="2014-04-16" version="1">MTINEIFVAHMRISVNPRVIWAARPPGEALASQNGMQNKLSEPPSLDSLQTTSVVDSFNLERAGRRGRFLGMAKLPFPAIGQALRRDTFGECLGLANPVGNTKRSAVATPRYVSSVRATCLYPLGSKEKTKSMAWMPSLLIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W6PQL8</accession>
    <name>W6PQL8_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF2470 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g000297</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PQL8"/>
    <dbReference type="OMA" id="VECFFFD"/>
    <dbReference type="OrthoDB" id="5553410at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.180.10">
        <property type="entry name" value="PNP-oxidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019595">
        <property type="entry name" value="DUF2470"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037119">
        <property type="entry name" value="Haem_oxidase_HugZ-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37783">
        <property type="entry name" value="MEMBRANE PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G04315)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37783:SF1">
        <property type="entry name" value="MEMBRANE PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G04315)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10615">
        <property type="entry name" value="DUF2470"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2470" evidence="1">
        <location>
            <begin position="4"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM26488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="213" mass="24407" checksum="9778B21AE8EA8427" modified="2014-04-16" version="1">MSSKDFIIKHMNADHQDSLVLFLQAYCGITSAQAKNAQLEEISTSYLIITAHGTRYSVPIEPAMKDYSEARGRMVAMHKESLKRLGRSEITLTEYRAPRGIQAVIFVLCFLFYITCFQRSNLQPGSEFYEYLGLQRVPWFPRLVCILQPYVVAIHIIETVLLVVTQLKPLNVPVMSGLWWKWVASCFVEGYGSFSRIKKFVKEQKAKKNGKSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W6PSC8</accession>
    <name>W6PSC8_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Deoxyuridine 5'-triphosphate nucleotidohydrolase</fullName>
            <shortName evidence="10">dUTPase</shortName>
            <ecNumber evidence="10">3.6.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">dUTP pyrophosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">DUT1</name>
        <name evidence="13" type="ORF">PROQFM164_S01g000942</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Involved in nucleotide metabolism via production of dUMP, the immediate precursor of thymidine nucleotides, and decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.</text>
    </comment>
    <comment type="function">
        <text evidence="2">This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>dUTP + H2O = dUMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10248"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61555"/>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <dbReference type="EC" id="3.6.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 10">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the dUTPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.23" evidence="10"/>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PSC8"/>
    <dbReference type="STRING" id="1365484.W6PSC8"/>
    <dbReference type="OMA" id="RSGMGHK"/>
    <dbReference type="OrthoDB" id="419889at2759"/>
    <dbReference type="UniPathway" id="UPA00610">
        <property type="reaction ID" value="UER00666"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004170">
        <property type="term" value="F:dUTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006226">
        <property type="term" value="P:dUMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046081">
        <property type="term" value="P:dUTP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07557">
        <property type="entry name" value="trimeric_dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.40.10:FF:000004">
        <property type="entry name" value="Deoxyuridine triphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008181">
        <property type="entry name" value="dUTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029054">
        <property type="entry name" value="dUTPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036157">
        <property type="entry name" value="dUTPase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033704">
        <property type="entry name" value="dUTPase_trimeric"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00576">
        <property type="entry name" value="dut"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001862">
        <property type="entry name" value="PRK00601.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11241">
        <property type="entry name" value="DEOXYURIDINE 5'-TRIPHOSPHATE NUCLEOTIDOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11241:SF0">
        <property type="entry name" value="DEOXYURIDINE 5'-TRIPHOSPHATE NUCLEOTIDOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00692">
        <property type="entry name" value="dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51283">
        <property type="entry name" value="dUTPase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 10" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="dUTPase-like" evidence="12">
        <location>
            <begin position="59"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="34"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU367024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDM27133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="188" mass="19730" checksum="D61498FECD25ABBB" modified="2014-04-16" version="1">MTKETTPPLQEKSLPAHNPPSLPTSPLPKRSKPDTMTTAAVTSIQQPLPPLLVKKLVESAQAPTRGSAFAAGYDIYAAKETVIPAKGKGAVDTGIAIAVPEGTYGRIAPRSGLAAKHFIDTGAGVIDADYRGEVKVLLFNHSDVDFPVKAGDRVAQLVLERIYTPEVSVVEELEESVRGAGGFGSTGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W6PTS9</accession>
    <name>W6PTS9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alcohol dehydrogenase superfamily, zinc-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g000990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PTS9"/>
    <dbReference type="STRING" id="1365484.W6PTS9"/>
    <dbReference type="OMA" id="YTINYRT"/>
    <dbReference type="OrthoDB" id="3509362at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08276">
        <property type="entry name" value="MDR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052711">
        <property type="entry name" value="Zinc_ADH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45033">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45033:SF1">
        <property type="entry name" value="OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="1">
        <location>
            <begin position="12"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM27181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="351" mass="38160" checksum="9A44CDB2334C10FB" modified="2014-04-16" version="1">MAVQQWITPLKGIDSLSRTEAPVPVPGPSEVLVEIRAVSLNYRDVEVTNGEYKHHRTANQDATIVPCSDMCGVVTQVGSGVSKWTVGDRVLSTFLPDHQTGQVTEKELARSLGLPQNGVLATHRVFPDYGLVKAPSFMSDEEAATLPIASVTAWMSINGLRPMGQSGGKDEYILLQGTGGVAIAGLQIAKAAGAKVIITSSSDAKLEQAKELGADFTINYRTNPNWEIEVMKVTENHGADIILEVGGAKTLRKSFDCIAFGGLIDCIGYVSGKIDADEDRLNVNLLALRRTVTLKGIINGPKDRFEEMIRFYEENQIHPVVNRVFSFADSKEAFRFLESGSHFGKVVIKVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W6PTW8</accession>
    <name>W6PTW8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glucose-fructose oxidoreductase, bacterial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S01g001025</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfo/Idh/MocA family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PTW8"/>
    <dbReference type="STRING" id="1365484.W6PTW8"/>
    <dbReference type="OMA" id="WTNFVHD"/>
    <dbReference type="OrthoDB" id="64915at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051450">
        <property type="entry name" value="Gfo/Idh/MocA_Oxidoreductases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055170">
        <property type="entry name" value="GFO_IDH_MocA-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43377">
        <property type="entry name" value="BILIVERDIN REDUCTASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43377:SF1">
        <property type="entry name" value="BILIVERDIN REDUCTASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22725">
        <property type="entry name" value="GFO_IDH_MocA_C3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="2">
        <location>
            <begin position="7"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="GFO/IDH/MocA-like oxidoreductase" evidence="3">
        <location>
            <begin position="138"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM27216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="357" mass="38910" checksum="B94CFFBDCDAF7818" modified="2014-04-16" version="1">MAESPKVRIALIGGGTIAPLHVKHLMSSPTCELVAIVDPYHPGRELASSLSLPHFESVASLLKALQKPPKAYVICVPSSLHVSIAIDVIYRARPKALLIEKPFCTDSKSGTELLALANEKGCKILVGHHRRFHPSLLTTRSVIETGKIGKITAISGLWTAKKDEGYFTSASWRATRSAGGGPIWTNFVHDIDALHFLTGARMTCVWAINTIPRRKHESVAADDIVEEGAAIMAQFSNGVVGTFLVSDNVASPYGWESATGDNPLYPKAEIQVDIYSILGTKGTIVVPDNTLWTYGSETTQVSPRGWVENSIDTRQASSRPGYFVSTSCRIKDIMRLTVVLLKSLELKTWLCGNLRFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W6PU90</accession>
    <name>W6PU90_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ribosome biogenesis protein SLX9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PROQFM164_S01g001261</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLX9 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PU90"/>
    <dbReference type="OMA" id="HKPGAMK"/>
    <dbReference type="OrthoDB" id="5429132at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028160">
        <property type="entry name" value="Slx9-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15341">
        <property type="entry name" value="SLX9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="116"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="119"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="155"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDM27450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="170" mass="19048" checksum="D42C8A3EC1A62349" modified="2014-04-16" version="1">MAPIRKSMTKTASGRGAIAKPSVFGDEFRTSKRDKRQIKHAALVSKIEKNSQKTPKRRRASKKLVANLESLADALPEAEESNDAASQVNVIKQKTLRHKPGALKRREKMERLERDRFNKNLTEMSNITSAPAANNGEASTESNPTASRWSALRNFISQTMEQQPVFKTNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W6PUV1</accession>
    <name>W6PUV1_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S01g001372</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PUV1"/>
    <dbReference type="STRING" id="1365484.W6PUV1"/>
    <dbReference type="OrthoDB" id="10414705at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM27561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="92" mass="10178" checksum="B997A1D996943114" modified="2014-04-16" version="1">MIQVRPDHFISPLAYLEVGPNGKKFTAPSGIIQSLRCRYKSSPEIIYVVDDDVEDIFGHILQYLHSGDYSVLIPAADSSSHAACEDEIEIAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W6PUY8</accession>
    <name>W6PUY8_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">dbp2</name>
        <name evidence="19" type="ORF">PROQFM164_S01g001417</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">ATP-dependent RNA helicase involved nonsense-mediated mRNA decay and ribosome biogenesis through rRNA processing.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Associates with polysomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PUY8"/>
    <dbReference type="STRING" id="1365484.W6PUY8"/>
    <dbReference type="OMA" id="STMPKFE"/>
    <dbReference type="OrthoDB" id="196131at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17966">
        <property type="entry name" value="DEADc_DDX5_DDX17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000008">
        <property type="entry name" value="ATP-dependent RNA helicase RhlB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000079">
        <property type="entry name" value="probable ATP-dependent RNA helicase DDX17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 14 19" id="KW-0347">Helicase</keyword>
    <keyword evidence="6 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="18">
        <location>
            <begin position="136"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="16">
        <location>
            <begin position="167"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="17">
        <location>
            <begin position="370"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="520"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="13">
        <location>
            <begin position="136"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="15">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="15">
        <location>
            <begin position="23"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="15">
        <location>
            <begin position="520"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CDM27606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="567" mass="60378" checksum="5567B68A60C97F8C" modified="2014-04-16" version="1">MSYGGGYSRGGGGGGDSYRSRGGDSGYSNGGSGGGGYSGGGGGYGGGRGGGYSGGGGYGGGGGGGYGGGAAGGDRMNNLGAGLKTQDWDPNTMPKFEKSFYKEHPDVTARSEEDIIAFRKEKEMAIQGTNVPRPVETFDEAGFPAYVLSEVKAQGFDAPTAIQSQGWPMALSGRDVVGIAETGSGKTLSYCLPAIVHINAQPLLAPGDGPIVLVLAPTRELAVQIQAEITKFGKSSRIRNTCVYGGVPKGPQIRDLSRGVEVCIATPGRLIDMLEAGRTNLRRVTYLVLDEADRMLDMGFEPQIRKIIGQIRPDRQTCMWSATWPKDVRQLASDFLNDYIQVNVGSTDLSANHRITQIVEVVSDFEKRDKMIKHLEKIMEDRSNKCIIFTGTKRVADEITRFLRQDGWPALSIHGDKQQNERDWVLNEFKQGKSPIMVATDVASRGIDVRDITHVLNYDYPNNSEDYVHRIGRTARAGAKGTAITFFTTDNSKQARDLITILTEAKQQVDPRLAEMVRFGGGGGGGRWGGRGRGGGRGGWGGGRGGGGGGGGFTASNSAPVGGNRRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W6PVV6</accession>
    <name>W6PVV6_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S01g001851</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PVV6"/>
    <dbReference type="STRING" id="1365484.W6PVV6"/>
    <dbReference type="OMA" id="GAMHWSG"/>
    <dbReference type="OrthoDB" id="540004at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43861:SF1">
        <property type="entry name" value="TRANS-ACONITATE 2-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43861">
        <property type="entry name" value="TRANS-ACONITATE 2-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="3">
        <location>
            <begin position="57"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM28040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="227" mass="25356" checksum="EF11222FB4151218" modified="2014-04-16" version="1">MPETTNHKIKSDIKKAYNEIASVYLTWTKPSHETRLSYLDLLLQSIHSAKETHQLNILELGCGAGVPCTQLLSSHAHISITANDISSTQIALAKERLPPSVNLILGDMMELEFSAEQFDAVMAMYSIFHLPRMEQTTMLRRIFGWLKPGGRLLANFSEAAFESSTNGPWLGATEGAMHWSGWGRDEVRRVLKEIGFGIEVDEVTVDREEDNGGGKSVGFHWVLARKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W6PX11</accession>
    <name>W6PX11_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g000313</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PX11"/>
    <dbReference type="STRING" id="1365484.W6PX11"/>
    <dbReference type="OMA" id="ILERPMK"/>
    <dbReference type="OrthoDB" id="4524805at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="180"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM26504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="281" mass="30619" checksum="3D16A03EE27D28AD" modified="2014-04-16" version="1">MNGSMVTIDESIVANDRQRAQHDMEMLYAAVMEHDAQKASGIDLSVREQDFHAQSPDSQLTNPFTDRGSHGSENSLAPLAPLKSPTKGFNSSRLSKLFNPGSRANPDPSKVRSPRLAIRKMPISSPLASPAVATPQAYVFENPPLSPRIYNPGPPPMVPQQHASESIRPAPGRARPPAPLTLSTPSPSSSVPSNLPFREAYPPQSAPATKTTILERPMKNRAGPLTGMATPYSPYMPFTPVTPFTPGRTVTKRQRKREERGNGLQVLNEDDLVKDDNDIWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W6PYD2</accession>
    <name>W6PYD2_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Sensitive to high expression protein 9, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">she9</name>
        <name evidence="15" type="ORF">PROQFM164_S01g002846</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Required for the maintenance of the structure of the mitochondrial inner membrane. Involved in mitochondrial morphology. Causes growth arrest when highly overexpressed.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 12">Homooligomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Mitochondrion inner membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the SHE9 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PYD2"/>
    <dbReference type="OMA" id="ERYMALI"/>
    <dbReference type="OrthoDB" id="5595506at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007007">
        <property type="term" value="P:inner mitochondrial membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008839">
        <property type="entry name" value="MDM33_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31961">
        <property type="entry name" value="SENSITIVE TO HIGH EXPRESSION PROTEIN 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31961:SF3">
        <property type="entry name" value="SENSITIVE TO HIGH EXPRESSION PROTEIN 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05546">
        <property type="entry name" value="She9_MDM33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="306"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="459"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="83"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="187"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="120"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU364128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CDM29035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="484" mass="54283" checksum="D78D04AEA248A71D" modified="2014-04-16" version="1">MQSMPQLLRQSLRSSLRLTSPSPVRAHFRPAFSVRPTPRSFSACVQCQFRRQPSTYLALNDREKFSADTERLIREKEKELAELELASRDPVPIPGLESGSSLDSVPPAEDEQSAAQSKPQTKEHEKEKSVSQEEDASVGTRSGGLPSYLESRRSKWSKQFSTVMDNLQSNVFVAGQRLNDLTGYSSIEALKKDIQFYENRLRTARANVKQAKEDYAAAINRRSTSQREVNELLQRKHAWSSTDLERFTLLYRNDHTNEVAETETSHALSAAEREAEEAAAQMSKSILSRYHEEQVWSDKIRRMSTWGTWGLMGMNVLLFLIFQILVEPWRRKRLVQGFEDKVVEALEKEKALNRAMFTENAVSITPRSNVTILPEIIDSTDENIIETAPSLLIEPKITTTEKDASTTGSIVSVTDATAAQSLKTRLSNITLPVLSVEYWRQVASEFFSDRSIAVSQYDLTAVALQSAAAGAAVTGLLFALIGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W6PYG8</accession>
    <name>W6PYG8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S01g002881</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PYG8"/>
    <dbReference type="OrthoDB" id="4355239at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM29070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="154" mass="17563" checksum="F18BF2AF59B709F0" modified="2014-04-16" version="1">MSHHKPAPIPVQFLYGPAKVALEAMIFLRIDSPVLLKWTPSENSSQDARMLLDACKALRNSRSRETYLDENISLEEGLRAFEGNVLHSLSYSTVLMLVLMTWHFDASSSEASWGLIAFLRQPYDNEVRRILQGRYSSIMRETAPSNFDFLLVLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W6PYU0</accession>
    <name>W6PYU0_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PROQFM164_S01g002997</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PYU0"/>
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    <dbReference type="Proteomes" id="UP000030686">
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    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="entry name" value="SPRY_SSH4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035780">
        <property type="entry name" value="SPRY_Ssh4-like"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="14"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDM29185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="320" mass="35041" checksum="0A912DA95192A84A" modified="2014-04-16" version="1">MSNQPHNDLPPSYDASQQSWGISGTKPQTGPSASANPPPYHNWQEAVPDTATFPPPPITGYLISGTGNASEDDAQRAHDFCNSVPLWLPAQPSSAVYHDVQVHDLRPVQPAELRGHVSAVARGRWRGHSVDGNGDCVVLTQLPMYFPATDSPFVREQKKTIYFEVKLLALRAGPTPQDCSGFSIGFAAQPYPSWRSPGWERGGLGVFSDDGCRFVNDSFGGRDFTMPFKVGETVGLGMEFELPENICSGDKHSKSCKVHIFFTRNGRRSESWDLHEEVDADSGDVEGLEGDYDLYGAIGLFGGVDFESCFDPAGWLWKPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2024-10-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>W6PZA8</accession>
    <name>W6PZA8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S01g001073</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PZA8"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM27264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="68" mass="7354" checksum="2455A161B20E3F38" modified="2014-04-16" version="1">MHLGGMYYWIKDGLGPVFLVLVILRRITGGSESCSSRTSTSGKVCNDIQPFKSPGRPDLNMPGVAEIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q0G5</accession>
    <name>W6Q0G5_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Carbamoyl phosphate synthase arginine-specific small chain</fullName>
            <ecNumber evidence="4">6.3.5.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Arginine-specific carbamoyl phosphate synthetase, glutamine chain</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Glutamine-dependent carbamoyl phosphate synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="primary">cpa1</name>
        <name evidence="21" type="ORF">PROQFM164_S01g003263</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Small subunit of the arginine-specific carbamoyl phosphate synthase (CPSase). CPSase catalyzes the formation of carbamoyl phosphate from the ammonia moiety of glutamine, carbonate, and phosphate donated by ATP, the first step of the arginine biosynthetic pathway. The small subunit (glutamine amidotransferase) binds and cleaves glutamine to supply the large subunit with the substrate ammonia.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>L-glutamine + H2O = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>hydrogencarbonate + L-glutamine + 2 ATP + H2O = carbamoyl phosphate + L-glutamate + 2 ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:18633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-arginine biosynthesis; carbamoyl phosphate from bicarbonate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Heterodimer composed of 2 chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CarA family.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.5" evidence="4"/>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q0G5"/>
    <dbReference type="STRING" id="1365484.W6Q0G5"/>
    <dbReference type="OMA" id="CFSVQYH"/>
    <dbReference type="OrthoDB" id="434at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005951">
        <property type="term" value="C:carbamoyl-phosphate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004088">
        <property type="term" value="F:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01744">
        <property type="entry name" value="GATase1_CPSase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000016">
        <property type="entry name" value="Carbamoyl-phosphate synthase arginine-specific small chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.30.20:FF:000003">
        <property type="entry name" value="Carbamoyl-phosphate synthase arginine-specific small chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.20">
        <property type="entry name" value="Carbamoyl-phosphate synthase small subunit, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01209">
        <property type="entry name" value="CPSase_S_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006274">
        <property type="entry name" value="CarbamoylP_synth_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002474">
        <property type="entry name" value="CarbamoylP_synth_ssu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036480">
        <property type="entry name" value="CarbP_synth_ssu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035686">
        <property type="entry name" value="CPSase_GATase1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01368">
        <property type="entry name" value="CPSaseIIsmall"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009475">
        <property type="entry name" value="PRK12838.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11405:SF4">
        <property type="entry name" value="CARBAMOYL-PHOSPHATE SYNTHASE ARGININE-SPECIFIC SMALL CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11405">
        <property type="entry name" value="CARBAMOYLTRANSFERASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00988">
        <property type="entry name" value="CPSase_sm_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00097">
        <property type="entry name" value="ANTSNTHASEII"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00099">
        <property type="entry name" value="CPSGATASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00096">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01097">
        <property type="entry name" value="CPSase_sm_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52021">
        <property type="entry name" value="Carbamoyl phosphate synthetase, small subunit N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Carbamoyl-phosphate synthase small subunit N-terminal" evidence="20">
        <location>
            <begin position="38"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00043861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00044031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00044168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00044334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00044340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00049285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="SMART" id="SM01097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="CDM29451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="455" mass="49205" checksum="1EFAB6AC679A75E7" modified="2014-04-16" version="1">MISNLFKAMPARASAFASMSRTSGQARFMATVRRAAMEPATFTIRDGPMFSGKSFGARSNISGEAVFTTSLVGYPESLTDPSYRGQILVFTQPLIGNYGVPSAEKDPNGLLKYFESPNLQAAGVVVADVAEQYSHWTAVQSLGEWCAREGVPAISGVDTRAIVTYLREQGSSLARITVGEEYDANEDEAFTDPEQIHLVRQVSTKQPFHVAAADPHSHVAVIDCGVKENILRSLVGRGSSVTVLPFDYPIHKVAHHFDGVFISNGPGDPTHCQDTVYHLKRLMETSQVPIFGICLGHQLLALAAGASTIKLKYGNRAHNIPALDLSTGRCHITSQNHGYAVDASTLPSDWKPYFINLNDQSNEGMIHKSRPIFSTQFHPEAKGGPLDSSYLFDIYLDSVLKYKNSQTGLYPQRDSRPSPLLVDLLAKERVGVQPTIGQQNVVAAAAASAAIAAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q0V3</accession>
    <name>W6Q0V3_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Protein kinase-like domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S02g000079</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM29930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q0V3"/>
    <dbReference type="STRING" id="1365484.W6Q0V3"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM29930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="286" mass="31921" checksum="BE59287EE2BEAB74" modified="2014-04-16" version="1">MIYDLNTINAQSQLPISISAPTTCESHTAATKKLTGSHCRSKLKESPWDTYRKVIIYKITGKVTIATRRTRPSRMVAIRIYAKENTRRLIYRFGRLEHRNVLSLHKCYIHKDLAFFLVDDLPLTLAYIVAFLSVYPNETELGSIILDGVFYLFTFGLAYQSLSCDHILFGIDGIIKIASLDLCIDCTPKQSEAAYIAALPSITMQLMQKFDKDQGVVGVIDLERWPIDSAAVGFLSATETAGSIKSLRNQPLLTGKHRPSEDLVVLARAALLSSSLNCVYNPDSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q2E7</accession>
    <name>W6Q2E7_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g002185</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q2E7"/>
    <dbReference type="STRING" id="1365484.W6Q2E7"/>
    <dbReference type="OMA" id="GNWAPSP"/>
    <dbReference type="OrthoDB" id="1746530at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038846">
        <property type="entry name" value="RPC9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15561">
        <property type="entry name" value="CALCITONIN GENE-RELATED PEPTIDE-RECEPTOR COMPONENT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15561:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="73"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM28374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="224" mass="24422" checksum="739BBAB60255D539" modified="2014-04-16" version="1">MRIIDPQTAVLTNVEVLAYLTSNPPRRPPPNSGNWAPSPDLRDHNTVVKEIHNYASRLSPHLLRYPRYTPRPSSSQSKTQSQAAMTGTLRTSNSANPEADTNSMPPPIPSAEITPMDTALRELVARLQPYGLTKAEVVMILNLGVGLSGNPATEEAREEGANGEESMEVDGEGEGEAEEDDYTAVVLMDGVIEERELRLSDEDVKAILAIIKETLTADYENVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q3G7</accession>
    <name>W6Q3G7_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Chromatin modification-related protein EAF7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PROQFM164_S01g002510</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EAF7 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q3G7"/>
    <dbReference type="STRING" id="1365484.W6Q3G7"/>
    <dbReference type="OMA" id="QHTRIPY"/>
    <dbReference type="OrthoDB" id="5595141at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012423">
        <property type="entry name" value="Eaf7/MRGBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13581">
        <property type="entry name" value="MRG-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13581:SF5">
        <property type="entry name" value="MRG_MORF4L-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07904">
        <property type="entry name" value="Eaf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="159"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="13"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="163"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="222"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="257"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM28699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="287" mass="31523" checksum="9D71FBB51A51E3BB" modified="2014-04-16" version="1">MPPKKKTKRAHSPTPQEDTVAESSANTPSSDSAGKSDTDYDLITDPWTDEQETALLKAIIKWKPVGIHKHFRMLAISDYLKSQGYAPSTAEHMRIPGIWKKLGSLYNLEALDEREDSAITDVNEDDKGSSEMYCAFELPYDEYGDMMFDRRLAMEESLSPVTSRASRAGGSRRGSTVADTDEPRSSPVPSRNRKPRPSTRGTRSTRLQVEIGPGSQGKISDEGGDSAEDTGANDEDDEEGEDGNSEEDEGEGEKGGSRSTRAQTSRSKAKDNRPSTGTATRRTARRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q3R7</accession>
    <name>W6Q3R7_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4211 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S01g002565</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q3R7"/>
    <dbReference type="STRING" id="1365484.W6Q3R7"/>
    <dbReference type="OMA" id="WRDFHIN"/>
    <dbReference type="OrthoDB" id="21499at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025451">
        <property type="entry name" value="DUF4211"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14689:SF0">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 82"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14689">
        <property type="entry name" value="PHORBOL-ESTER_DAG-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13926">
        <property type="entry name" value="DUF4211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4211" evidence="2">
        <location>
            <begin position="374"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="508"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="16"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="107"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="316"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="509"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM28754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="633" mass="71871" checksum="AE6CE444482F20EA" modified="2014-04-16" version="1">MPPRKSKKKQTRLAFAASAASPSADASPESSRYATLTYDHPSLGTYRPPKSLNSESGTSPASKRPKLPAKTRSKDKPTNELFVEKSSHESLDETIIPASQKRKQVAPPDNLDPVNLDDAQDSKNSRSRKSQQSLECSRTDSESTNGSDSEELSRPRRSLKRRAPSSPIDSSDSDEPVASSAPNRRRSTRGGHSSSSPVILSGDYSNESVAPSTAKRRRVARPAVVSERDEVDSDEPLASSPVKRLRRGKAKESPQAPHTPRHISQQARLDIAEDLEDLQDSVVKKSRTRGRNVESARDKRMKHLEALRRRRAGMKDEEEEQEDEEDDDDEEESDPDVQEIKQPSVRSLWRHDDGDSDIESAIDPNENLDRYEDDFVLEDEANDLGVPTEELPFEFTRHAYKQPKEYFRDVIGWMVQNKLNPAFPRSDDMYKMAFMKLEDEVKGRAGSQLISSVWNPSFVYALQARPHMEVDTFPTEDNHPCDACRRSGHPASREMKLYGKAYSLQTLEPLEDDSDEDSNNDDDGNDRDRDGHVIPPENVRYYLGKQCNARAQLTHTLTHWRYHLNEWVIDFLERTGHMDADEILRRNDMSVKRKTRNANDVLDSMTGSGEVDKLWRDFHIKLKSAREKESIYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q3S2</accession>
    <name>W6Q3S2_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="8">pH-response regulator protein palH/RIM21</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">palH</name>
        <name evidence="8" type="ORF">PROQFM164_S02g001145</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the palH/RIM21 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q3S2"/>
    <dbReference type="STRING" id="1365484.W6Q3S2"/>
    <dbReference type="OMA" id="PRQIWAN"/>
    <dbReference type="OrthoDB" id="5393256at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071467">
        <property type="term" value="P:cellular response to pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014844">
        <property type="entry name" value="PalH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35779">
        <property type="entry name" value="PH-RESPONSE REGULATOR PROTEIN PALH/RIM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35779:SF1">
        <property type="entry name" value="PH-RESPONSE REGULATOR PROTEIN PALH_RIM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08733">
        <property type="entry name" value="PalH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="226"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="268"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="299"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="386"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="426"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="626"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="719"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="398"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="437"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="719"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="737"/>
            <end position="761"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM30995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="761" mass="83794" checksum="89B98E8EA25B550A" modified="2014-04-16" version="1">MENDFHLLPRQIWANPTPTTTKVYTPGCTPVVLPINGLVYLNKSFAITLSENAVFEPVCTGSPTDEVHISAVLDTRDPFYSSITPQLYAIGCATVVSYLLVIILLITPRTFYVGGPGGGANFLGRHGMISGSYSGNSSVVGVGGRPWLQKVAAILVAISLTIATVDSFRVAERQYNYGFSDAEALSQEVIDGMEIRIVRVISSTFLWLAQVQTLIRLFPRHKEKVMIKWAGFALIVLDTTFSILDNFWARNAPTRPRLYEDAIPALSYLFELSLNLLYAAWVIFYSISKHRYAFFHPKMRNICLVALLSLCAILIPVVFFVLDIAKPEVAGWGTYIRWVGSAAASVVVWEWVERIEALERDETKDGILGREVFDGDEMLEVTPSEEVDWPRFSPQGHDQGGGNGASSGWGGVMGLAHRPLRARAGLPLGNRNKRARAPPYSQAAASAPRGPNGHRPTPPPAAITPISRADTTSAASTVYNVRYHPVASPTPPVAMPNMHEEEEMDEAKELEGREPHTPGIHNQALSVQNTREQSPQIVQADPRWHVLLHPFKRRRASLPKEVAYAQAEEEFSEHRPSAAAEEAEAEAKAARSRADLFFSLHRKARPGAGPQNTDGSLPVTVIPARRRGQHTWSPQNRLLEDTQPPGESRPIEPQHHGAPSTRPNLPVRVIPSRPEASAPWTEADVERGGGDYVLHYDPEAAALINEDISHLDRELVTNYDQQSWTDTSYSEERNDVSAEQTGTSESLVHGPSNGQHGQSSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q3U0</accession>
    <name>W6Q3U0_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein family Cys-rich</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S02g000791</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q3U0"/>
    <dbReference type="OMA" id="RQRAWSY"/>
    <dbReference type="OrthoDB" id="1045822at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006461">
        <property type="entry name" value="PLAC_motif_containing"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01571">
        <property type="entry name" value="A_thal_Cys_rich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15907">
        <property type="entry name" value="DUF614 FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04749">
        <property type="entry name" value="PLAC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="421"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="124"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="421"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM30641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="451" mass="50455" checksum="E224F72ED8BEC3B8" modified="2014-04-16" version="1">MSRLNVDTGGNHERYSFMETPLEMHPSSHQQSLSALPPAGANAHPQHPAVDEQQKERQRAWSYVPSEKEQFQHQGIIPDYANRPPLEQHPANYAPLVQNQEQQQQHSTSISPQTSTIAPEQQQHHTQSYTSQSYTNVAEQPSHTVSPQTYASQSYTNTPEQQQHQWHQQIGMTISPQYANIPERQQNSTPMSPHSYASHPYATQSYHIPNQHRDIEIPSQQYASYTETPSSPPPNSPGPLPLKVNPEGPPRSESVPIVPDENPLQSPISPYFPPITRPKTSHAPQPDDLSSYHQPGQTTHPNQEIKGGGWSNGLCEFSNFGICCLGLLCPCILYGRTQHRLSMKSRKEDPTNMLGYETCNGSCTAMGLLCGCQWLLATVQHTRTRKAYGIQGSIASDCVRATCCTCCTLIQDEKEIQKREEYRSRAARERGTTLLSPYTTPGPMSYGPPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q497</accession>
    <name>W6Q497_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Nucleotide-binding, alpha-beta plait</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PROQFM164_S02g001593</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q497"/>
    <dbReference type="STRING" id="1365484.W6Q497"/>
    <dbReference type="OMA" id="KIERCKA"/>
    <dbReference type="OrthoDB" id="271725at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000323">
        <property type="entry name" value="RNA binding protein MSSP-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24012">
        <property type="entry name" value="RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="275"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="363"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="472"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="550"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="40"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="484"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="519"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="550"/>
            <end position="563"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDM31443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="601" mass="65748" checksum="4063F3B43A20795C" modified="2014-04-16" version="1">MHPQGSQHTSSSGSGSCQTSSSQSAQYPQEPRTPYGPRYHQSTNPSSIDSSGAGLTNLFRGLNLQNSRPKFNGSKGTAPVQMNTNMDWSNTNRAYNSPFILVPNSTVFNGVPTVSSFVPNGVSGQTDQMGQFSYLPTGVYPNVNPVMAGGYSSWPYMMNYDMQDGTTNKQAWVSEGQKGVQGENNGQINYYPSALVSGMDGSSMSGYSYGGMVPSQLGSLSLPLQMMKTPNGYVVQDLEALTQQDPAIPRAVPAMWTNPSELTLAKCLENREGITNVYIRGFLPETTDEMLHAYAARFGKIERCKAIVDLDTSLCKGFGFVQYYSFESCENCIRGFFYLGYQASFAQKSRNSRLKDLEDKSSTNIYCTNIPIDWTEADLRRHFEPWRVVSEKISRDEKTGVSKEVGFARFENRDVAEKVLMEFHNVTKDDGVKLLLRFADTKAQKILKQQSNERRAYRAGEYNYSVEVVQGSTPSPGMKRGSHLTPNSQVSYTSPAGVGANWTPATSISPCHPHMKNPSSSARSSSLSSRSLNALDHTPAYRSRALSLNRGSYTDLSGGSSKTAMPDSPTMGSRKENIRAGSVSPASSSPMIILSPARSCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q4D9</accession>
    <name>W6Q4D9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PROQFM164_S02g001643</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q4D9"/>
    <dbReference type="STRING" id="1365484.W6Q4D9"/>
    <dbReference type="OMA" id="ICLYEKT"/>
    <dbReference type="OrthoDB" id="2373987at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056337">
        <property type="entry name" value="LHD_YVC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052971">
        <property type="entry name" value="TRP_calcium_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056336">
        <property type="entry name" value="YVC1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35859:SF4">
        <property type="entry name" value="MEMBRANE CHANNEL PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G11300)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35859">
        <property type="entry name" value="NONSELECTIVE CATION CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23190">
        <property type="entry name" value="LHD_TRPY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23317">
        <property type="entry name" value="YVC1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="326"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="355"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="379"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="422"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="460"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="489"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="515"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="domain" description="YVC1 N-terminal linker helical" evidence="3">
        <location>
            <begin position="93"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="Calcium channel YVC1-like C-terminal transmembrane" evidence="4">
        <location>
            <begin position="331"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="742"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1026"/>
            <end position="1090"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="809"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="858"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1026"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1049"/>
            <end position="1062"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1078"/>
            <end position="1090"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDM31493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="1090" mass="123286" checksum="0273984B18F58934" modified="2014-04-16" version="1">MFASLLRPKRQRGQVEQSPFSTPSPWFRSTHNNSRRVPRADESSDDAPELHEIDEEDMDQDWEEGEEEEDGPLESTPLLPMFSASHLDALPVYNITHAIRPLIASRCETTLTWDQLRSPQVSQFLIKPILQKIMSAHFSRATLYALMANCLQFEREIHLSPGNSGANQTRAMVSELLAIKLLREYSTRELIDALSYEFYPLQGQDQSTILVTGPHRKRVVAARVSCLEVAIRAQAKRFLAHPVVVQQLEAIWAGTVVFHSAADSLHRSMSMNQGGNLDYGATMDPNDDNTTESSNKILRRSVTIYNPRDASLFKLSRLRVPRYRQFLSTLSFAVLLGLFLAVLEQRSRRITSLEILFWFWSAGFMLDEVVGFNEQGFSLYLMSFWNLFDVGILLLLFAYYCLRIYGTFLTYPRSEYIADQAFDVLTATAPLLFPRLFSILDHYRYFSQLLIAFRIMASDLIAVFVLIVISCSGFFVSFLYFGDNKSPKVVAYGLFQMLMGFTPTAWAMWDEYNFLGRTILTVFLFICHFVVVTILITVLTNSFMRIVQNANEEHQFLFAVNTISMVKSDALFSYVAPTNIIAWLVTPFRSLMPFRDFIRLNRTIIKITHLPILFTICLYEKTILSSRVVQPMDLIEPTSQNETPAHIQQPRRFRGFSTSASVLRREPSVATYQKDRALEEVFRRPYRGDRMRGPPSTVHERQTNNVIKDWMQEIGSGPANGPDDVDSLVADRHGMHRQRFKFPFRARLSNPPRDFTETTRSVASNPEDRTSCAASPVIRSRRTRPSISPTQKRQLSLHTDMEGDDELTSNDGDSNDNKQSALGSTGETADSVEGAERPSPKFYSSRPSTARMMSRRNSPTRRIRHTRNASGVTMLYNPVGSLDEETEGRVTPTRPDTDSSDGESPPFASTSLDQGTMKRHDISRARNPPIGLHMSVPDIDYLTNRSTGTRPRSSLLYDLGSDLGDNKAVASGFSGALPSSFQTQLGFAPPVRREPPTQTQDMLSKLVLARMNNIEEGFREVIKEFKDLRRSESSRSPSRPDESRGATREKKKRDKKDSKKKSVASPASRAASGEDPFTGNQPGDDTLPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q4H8</accession>
    <name>W6Q4H8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g002890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q4H8"/>
    <dbReference type="STRING" id="1365484.W6Q4H8"/>
    <dbReference type="OMA" id="WAACAIR"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054471">
        <property type="entry name" value="GPIID_WHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GPI INOSITOL-DEACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GPI inositol-deacylase winged helix" evidence="1">
        <location>
            <begin position="82"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM29079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="138" mass="15591" checksum="598FCF1F1FAC1972" modified="2014-04-16" version="1">MDKSMPLRILVTSRNTVDLDQGIVGPDERDTLAEKILDKSKGSFLWTVLVLEELLRCHSRKEIYRILENVPRGMESLYKRTLDYMSQAVRGKELAKTILIWAACAIRPMTISELGGALSLDIHDSFLRLEESIVALCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2024-10-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q4Q2</accession>
    <name>W6Q4Q2_PENRF</name>
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            <fullName evidence="1">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
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        <name evidence="1" type="ORF">PROQFM164_S02g001460</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1">FM164</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM31310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="95" mass="10984" checksum="71BC811E54EA1ACB" modified="2014-04-16" version="1">MRVYNVFQTWRGLEKTDKGKLTKKRSKPCLCDRFPLCLHPSPPWNDPKAVLAPRYWIVTITPDPAPIRWGRLHAQWARVPMLASFRATQTQNGVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q4Y9</accession>
    <name>W6Q4Y9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sec62/63 complex, subunit Sec66</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S01g003051</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q4Y9"/>
    <dbReference type="STRING" id="1365484.W6Q4Y9"/>
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    <dbReference type="OrthoDB" id="73168at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031207">
        <property type="term" value="C:Sec62/Sec63 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031204">
        <property type="term" value="P:post-translational protein targeting to membrane, translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Sec66"/>
    </dbReference>
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        <property type="entry name" value="TRANSLOCATION PROTEIN SEC66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28229:SF1">
        <property type="entry name" value="TRANSLOCATION PROTEIN SEC66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09802">
        <property type="entry name" value="Sec66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="217"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="242"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM29239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="264" mass="29446" checksum="29B8842A9F4A524A" modified="2014-04-16" version="1">MFDVDWLSLAVPVAYLGILLGSLATFSSLYRKRKSHKAASLEPWFPAHLQRDIYFSLLHLEPSTTSTKEKKAPAIPDSIFKASLLRRAAEDIRRIMALRTQKQALTTLVQRGSVGDDLWQRFQRAEKEMEDEVKDVVSEANAYVPGWGQTIFQSANEMMNNDIYRKRMDDQQKKLEEERQWWIKKKTSIQEGFMKELNEGSVASTDEAKTTNITTKSSEAASTAPAAGASIQGSDDDAVLVEAETSSTPASPASAKKKKGKGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q5V3</accession>
    <name>W6Q5V3_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ion channel regulatory protein, UNC-93</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PROQFM164_S02g001851</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q5V3"/>
    <dbReference type="OMA" id="ALYLFWV"/>
    <dbReference type="OrthoDB" id="196103at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010291">
        <property type="entry name" value="Ion_channel_UNC-93"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051617">
        <property type="entry name" value="UNC-93-like_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294:SF19">
        <property type="entry name" value="DUF895 DOMAIN MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294">
        <property type="entry name" value="ET TRANSLATION PRODUCT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05978">
        <property type="entry name" value="UNC-93"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="69"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="126"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="163"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="254"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="286"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="319"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="359"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="424"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM31700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="468" mass="51449" checksum="9520F77B22735A0E" modified="2014-04-16" version="1">MTNSEKEAVPSEKVDSAGSITSPVGGPHKVKWYRSTFYNAFILGLCNFLAPGIWGAMNSLGGGGEEKPYLVNAANALTFGLMVVSCFFSSVLVRFIGIKWALIVGTMGYAPYAAGLYTNNRFGVEWLVLLGAALCGISAGIFWMAEAAIALSYPEPYNQGRFLGFWLSFRVGGQILGGAINLGINANRSNSGSVSYTVYLIFIALQALGPFAGLLLSNPSQVQRKDGVPVNLQVTKSITHELKSMWKLWINRKFLYIIPFICQAVYTEAVMFSYEGLWFSVRARALGSFLSGVVAVTIGNILGAFLDSKRVSLKNRTRYAFYFVVAWQGMCWIWATVVTTEFNETHPTYDWSTPGFGRAFALFLFWVAGFQLNYMYLFFLVGNLADDQEEVVRIAGLLRGTESAAQCVSYGLSSVNIMAAVGSIYLNFGLWAIAIIPTWIIIKDIGTAFEDKKIARETPGLREAVDQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q6F8</accession>
    <name>W6Q6F8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sphingolipid C4-hydroxylase SUR2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">SUR2</name>
        <name evidence="8" type="ORF">PROQFM164_S02g001746</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q6F8"/>
    <dbReference type="STRING" id="1365484.W6Q6F8"/>
    <dbReference type="OMA" id="FFIFWDR"/>
    <dbReference type="OrthoDB" id="408954at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050307">
        <property type="entry name" value="Sterol_Desaturase_Related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11863">
        <property type="entry name" value="STEROL DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="195"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid hydroxylase" evidence="7">
        <location>
            <begin position="205"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="405"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM31596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="424" mass="48053" checksum="DEEEE82819B80F71" modified="2014-04-16" version="1">MAMNASVAFDLPPLPTYTLTPQGHLLAFLPDNILSLVLPVIAYWVLSMIYHYLDVNDYFVEYRLHTPAEVLKRNKVTRWEVVRDVVLQQVIQTVAGLAFLYFDAEETVGREEYDVAVWAQRLRIAQKAFPSLLALVGVDAISLGKSVSQSGYTMLAGALAGGSYPDVTQSIILDNGAEAVAPAFTSWELAVASFIYWYFIPTLQFMLAISIVDTWQYFLHRAMHLNRWLYVTFHSRHHRLYVPYAFGALYNHPVEGFLLDTAGTGIGFLVSGMTTRQAMWFFTMSTIKTVDDHCGYAFPWDPLQHFTSNNAAYHDIHHQSWGIKTNFSQPFFIFWDRLLGTRWTGEVKPRYERARENAQKQVDLDAAQALNNTPAVTLTGERERERERVVVSTEGPAARTRLRRKTVDSLKGPSHGVPGSVLHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q6G9</accession>
    <name>W6Q6G9_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Efflux pump dotC</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Dothistromin biosynthesis protein C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PROQFM164_S02g002091</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Efflux pump; part of the gene cluster that mediates the biosynthesis of dothistromin (DOTH), a polyketide toxin very similar in structure to the aflatoxin precursor, versicolorin B. One function of dotC may be to transport early-stage dothistromin biosynthetic intermediates from the cytoplasm into vacuoles, thereby affecting the rate of dothistromin production.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. TCR/Tet family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q6G9"/>
    <dbReference type="OMA" id="GNKKGWL"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000014">
        <property type="entry name" value="MFS drug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000196">
        <property type="entry name" value="MFS toxin efflux pump (AflT)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF102">
        <property type="entry name" value="DRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G08530)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01036">
        <property type="entry name" value="TCRTETB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="68"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="195"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="229"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="260"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="292"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="332"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="365"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="395"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="426"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="459"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="539"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="71"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="567"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="38"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="575"/>
            <end position="598"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00057269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00069956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00083178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDM31940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="598" mass="64947" checksum="EC035EDF187BBB74" modified="2014-04-16" version="1">MSERQQPDASSSNTEIDQPHTEKSPDTPDQVTEVAGQHNDENLTEKTTEGAPLDHAPSQAAKMGKKKIIVVMMALCLALFLAALDMTIISTALPTIAAQFGASESGFSWIASSYLLANAACIPLWGKISDIWGRKSIIVLANVVFLVGSLICALAHNMATIIAGRAVQGVGGGGIIILANISVSDLFSLRDRPMYYGLFGATWAVAGALGPVIGGAFTTEVTWRWCFYLNLPVGGVSLAILVLFLHIESPKTPFWAGLRCIDWTGTFLIIGGTLMFLFGLEFGGVNYPWASPTVICLIVFGVLTWALAMFLEWKVAKFPIIPPRLFNEWYNILILLVCFCHGFAFIAATYYLPLYFQTVLQATPILSGVYVLPLVLSLAIGSAATGVVMKKTGRFRELIIGGMTLMSLGFGLFIDLKAYASWPRIIIYQLITGIGIGPNFQAPLVAFQANIRPADMATATATFGFVRQLSTSMSVVLGTVIYQNIMSQQSAKLIAALGAEDAAIVSASFSSSSKALIKRLTPSQRKVVMEAFTHALNRMWIFYTAIACLGFVLALLVRRRELTRHHTVQKTGLAEQERARQELIDSQRKADSKPEIEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q6U9</accession>
    <name>W6Q6U9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Zinc finger, RING/FYVE/PHD-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S02g002584</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q6U9"/>
    <dbReference type="STRING" id="1365484.W6Q6U9"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051826">
        <property type="entry name" value="E3_ubiquitin-ligase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22765:SF434">
        <property type="entry name" value="GB|AAD18119.1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22765">
        <property type="entry name" value="RING FINGER AND PROTEASE ASSOCIATED DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="3">
        <location>
            <begin position="189"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM32433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="241" mass="26701" checksum="9A77F68643714F56" modified="2014-04-16" version="1">MSATPNGPTASTAVTAVICAALIIGLCFAAFTRWFCYIRRRSTEGNPAAVPPSVFQLQANQSKVQEKPLTVEDLNKYLPMIEYKMWKSQQYEQRMSFPQTATEAQKTLSDPNVSALLPQSPTEDPVHLSNLNASVGAQGQVNLSEEVRSKDRLFEFSLTPKAPESSCQTIQSAVSPVWPVEKTVSGDACAICLDTMEDEIKVRGLPCDHAFHVDCVDKWLLWRRACCPVCRYACKIPPKVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q881</accession>
    <name>W6Q881_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Small nuclear ribonucleoprotein G</fullName>
            <shortName evidence="10">snRNP-G</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">snr-7</name>
        <name evidence="12" type="ORF">PROQFM164_S02g003064</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Plays a role in pre-mRNA splicing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the heptameric LSM1-LSM7 complex, which consists of LSM1, LSM2, LSM3, LSM4, LSM5, LSM6 and LSM7. Component of the heptameric LSM2-LSM8 complex, which consists of LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8. The LSm subunits form a seven-membered ring structure with a doughnut shape.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q881"/>
    <dbReference type="STRING" id="1365484.W6Q881"/>
    <dbReference type="OMA" id="MSKAQPP"/>
    <dbReference type="OrthoDB" id="2146at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034719">
        <property type="term" value="C:SMN-Sm protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097526">
        <property type="term" value="C:spliceosomal tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005687">
        <property type="term" value="C:U4 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01719">
        <property type="entry name" value="Sm_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000019">
        <property type="entry name" value="Small nuclear ribonucleoprotein G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044641">
        <property type="entry name" value="Lsm7/SmG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034098">
        <property type="entry name" value="Sm_G"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10553">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10553:SF2">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 10" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10 12" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 10" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="11">
        <location>
            <begin position="3"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDM32913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="78" mass="8873" checksum="EABE56ED138FC9CF" modified="2014-04-16" version="1">MPQAQPELKKYMEKRVFCQLNGNRKVIGILRGYDVFMNIVLDEAFEEKDGAEKVAIGMVVIRGNSVVMLEALERISDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q8G0</accession>
    <name>W6Q8G0_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Cytochrome b561, eukaryote</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PROQFM164_S02g000678</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FM164</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q8G0"/>
    <dbReference type="STRING" id="1365484.W6Q8G0"/>
    <dbReference type="OMA" id="WASIFLH"/>
    <dbReference type="OrthoDB" id="432881at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140575">
        <property type="term" value="F:transmembrane monodehydroascorbate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08761">
        <property type="entry name" value="Cyt_b561_CYB561D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045150">
        <property type="entry name" value="CYB561D1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006593">
        <property type="entry name" value="Cyt_b561/ferric_Rdtase_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15422:SF45">
        <property type="entry name" value="CYTOCHROME B561 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15422">
        <property type="entry name" value="OS05G0565100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03188">
        <property type="entry name" value="Cytochrom_B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00665">
        <property type="entry name" value="B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50939">
        <property type="entry name" value="CYTOCHROME_B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="148"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="186"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="210"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b561" evidence="13">
        <location>
            <begin position="40"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDM30529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="241" mass="25953" checksum="98984381ABD7E7FC" modified="2014-04-16" version="1">MASATGIPQAHPVTIESREDEPLLGRPGDVTQKAEEAIYRNLFTGTASVAQAGIWILAALVWQGVLAQPLSLFTPHPLLGSSALLLQVQAALILQPTATPQQKRTGTRIHYSFQLLSVVLFVSAFVIIEVNKGSHPHFVSPHGIPGLVTYIAIVLQAVVGVIQYFAPVTVLGSVDAGKRIYKYHRWSGYVLLLLEMATIVAATQTTYNLMAIHIPLWGVVVAAIFILAGVGARIKKHKLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q969</accession>
    <name>W6Q969_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type DNA-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PROQFM164_S02g003370</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM33218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q969"/>
    <dbReference type="STRING" id="1365484.W6Q969"/>
    <dbReference type="OMA" id="WGEEDIS"/>
    <dbReference type="OrthoDB" id="2943660at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050675">
        <property type="entry name" value="OAF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069:SF31">
        <property type="entry name" value="MONODICTYPHENONE CLUSTER TRANSCRIPTION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069">
        <property type="entry name" value="OLEATE-ACTIVATED TRANSCRIPTION FACTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="25"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="75"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="173"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="83"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="108"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="181"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM33218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="450" mass="49641" checksum="270CC94C0958EF0B" modified="2014-04-16" version="1">MAETSTKRSLQSNGQLLRNQKMRTTCNACQQAKIRCSHTYPCDRCESHGYQCVYSISQPLGRPAKRKMIRPAAAGTGIKMRRKEVEGVDRPTRLAPEERAQRARRVPSRIPSPTTSSGSGPSSREESYKSDPSTGTEVTPPKGNFQWSSFTNLLSDVAGNHKIGQGIQDHEAENRADPGFSDTSPDSSFEQNDGFESSGGPRFSGRVDYSTQCYTSHIGLMVDEPPIEGFLHTAAPDIQSGSLFQGGAIYPFSLAPNAIQVSGTVRNPARIMDLPSSEIWHEPVDTDSSQSLPLEDIDLEALPEDASSLHCNCYAQAFSEVMQSEEVNGPNKILLHLERVQQQGVVILQCQVCFASNARANILTLLVMAIEKAARALKVRAKLATTSVQGGVCSVWGEEDISQMRRCLSHLSIIVRFIHQDLHWASPSKWHLVMANETDRRLQSIIRIFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q9K0</accession>
    <name>W6Q9K0_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Translation initiation factor IF-2, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PROQFM164_S03g000027</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q9K0"/>
    <dbReference type="STRING" id="1365484.W6Q9K0"/>
    <dbReference type="OMA" id="DPFVAGN"/>
    <dbReference type="OrthoDB" id="361630at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01887">
        <property type="entry name" value="IF2_eIF5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03702">
        <property type="entry name" value="IF2_mtIF2_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03692">
        <property type="entry name" value="mtIF2_IVc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000008">
        <property type="entry name" value="Translation initiation factor IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10050:FF:000001">
        <property type="entry name" value="Translation initiation factor IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000019">
        <property type="entry name" value="Translation initiation factor IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10050">
        <property type="entry name" value="Translation initiation factor IF- 2, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1060.10">
        <property type="entry name" value="Zinc finger, RanBP2-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00100_B">
        <property type="entry name" value="IF_2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053905">
        <property type="entry name" value="EF-G-like_DII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044145">
        <property type="entry name" value="IF2_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006847">
        <property type="entry name" value="IF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000178">
        <property type="entry name" value="TF_IF2_bacterial-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015760">
        <property type="entry name" value="TIF_IF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023115">
        <property type="entry name" value="TIF_IF2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036925">
        <property type="entry name" value="TIF_IF2_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00487">
        <property type="entry name" value="IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381:SF20">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR IF-2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR IF-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22042">
        <property type="entry name" value="EF-G_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11987">
        <property type="entry name" value="IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04760">
        <property type="entry name" value="IF2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52156">
        <property type="entry name" value="Initiation factor IF2/eIF5b, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01176">
        <property type="entry name" value="IF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50199">
        <property type="entry name" value="ZF_RANBP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RanBP2-type" evidence="16">
        <location>
            <begin position="135"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="Tr-type G" evidence="17">
        <location>
            <begin position="404"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="160"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="258"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="698"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="28"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="118"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="180"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="220"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CDM33303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="924" mass="103153" checksum="07EDA42EBDB399D6" modified="2014-04-16" version="1">MNSSTQENNPFGEETPGSHMKWSRETPRNQGTNPSTQEKNPFKEENPGSYMKWPKGTSRDQERNPSTPERAPFEKENGGGYMRWPKGTSRNQERNPSIRATKAANEEENPFAPEKTQNRSQGQFQNKATRDHPMAHDDWNCPQCMKHVFATKQVCPFCKTSRPADAQPRSRITREYSDSPGRSQFQESRSPPEYTRKFQQLGDSVLSELEQDVKLNTTRNTERDSEEFDRPQTKEEADNFKKNQWTWDMSALEQLEKLEAQEQPPPPKPMKRRDGRKGRESESDGADFDSEDRERLRRERRRQQKEKDAQRAAKKAAALAAPAPLYLPEFISVSNLADVIGVRPAQFVQRMEEMGFEEITYRDVLDAETAGLVAAEFNYEAIFDSGKADLHAAPELEDTSNLPTRPPVVTIMGHVDHGKTTILDWLRKSSVAASEHGGITQHIGAFSVTMPSGKAITFLDTPGHSAFLEMRRRGADVTDIVVLVVAADDSVKPQTIEAIKHATQAKVPVIVAISKIDKEGNNPDRVKADLSIHGVHVEDYGGDVQAIGVSGKTGQGMLELEEAIVALSEMLDHRASTVCNVEGWIIEASTKSYGRVASALIRRGTLRPGDIIIAGTAWARVRTLRNQAGVTISEATPGMPVEIDGWREQPGAGTELLQAPTEQKAKDVVDYRLERSDTQKMGVDMIAINEARRELVEKRRREREEEETTQDVEPTGPKSVNFILKGDVDGSVEAVLNSVAAVGTNEVFANIIRSGVGPVSEFDIEHAGSAKGKIISFNQAIDPNIMRMAEAENVEILDHNIIYKLIDDVKAILSEKLPPTVTMRVTGEAEIQQVFEITVKGREKTAIAGSRVRNGLINKTRKVRVLRGEEIVYDGAMVSLKNVKKDVIEMRKDTECGIAFENWTDFAPGDHVQCYEEISEKRYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q9M1</accession>
    <name>W6Q9M1_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Fumarylacetoacetase, C-terminal-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S03g000052</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAH family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q9M1"/>
    <dbReference type="STRING" id="1365484.W6Q9M1"/>
    <dbReference type="OMA" id="WSYAKGM"/>
    <dbReference type="OrthoDB" id="411064at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018773">
        <property type="term" value="F:acetylpyruvate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050163">
        <property type="term" value="F:oxaloacetate tautomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006107">
        <property type="term" value="P:oxaloacetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.850.10:FF:000002">
        <property type="entry name" value="2-hydroxyhepta-2,4-diene-1,7-dioate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="entry name" value="Fumarylacetoacetase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820">
        <property type="entry name" value="ACYLPYRUVASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820:SF7">
        <property type="entry name" value="ACYLPYRUVASE FAHD1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="FAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumarylacetoacetase-like C-terminal" evidence="3">
        <location>
            <begin position="95"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM33328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="304" mass="32960" checksum="49827CDDA6675746" modified="2014-04-16" version="1">MGISNMNGTEFTETPAKHPVWKRWVRFRAEDGKIYGGEPVNPDIDVGQAIEKNAEVPVKVVAGNSAFDYDALFTGEIKTIDELLSPVSQIEAGAVRCIGLNYKEHAAEMKLTLPNTPTVFLKASTCIASACEPIVLPSNVDYDEADYEVELAIVIGRKCKNVSVSEAVHYILGYAVANDVTARKHQEKTSQWSYAKGMDGFCPLGPCIVSTEQIPNPAVLNLKTRLNGKIMQNESADDMIFNVPEIVSYVSQGHTLLPGTVIITGTPCGIGISQSPPQFLQPGDELRISISHGLGTQICPIVRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q9Z8</accession>
    <name>W6Q9Z8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thioredoxin-like fold</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S02g003387</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM33235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q9Z8"/>
    <dbReference type="STRING" id="1365484.W6Q9Z8"/>
    <dbReference type="OMA" id="GMVQHHR"/>
    <dbReference type="OrthoDB" id="9932926at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051033">
        <property type="entry name" value="SH3BGR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12232">
        <property type="entry name" value="SH3 DOMAIN-BINDING GLUTAMIC ACID-RICH-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12232:SF0">
        <property type="entry name" value="THIOREDOXIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM33235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="342" mass="36828" checksum="AF4051F37516E18E" modified="2014-04-16" version="1">MSDSTLYLYTSLTAGSSHIITATSRIETILKANKIPFRAIDVATDDAARKLWGRRSKGKKIPGLVKYGDIVGDLEEIEEWNEFGELRMVVNSVQDLGGMPPTSYPLPATEPKAESTPTTLKPSTIKIQNPPVTKHEDKKDDMTVLALRQASSEAAAKAKTKSDDKKDAKAQATGVPVASRAHRGSVAPELPDTAPESSQATRRPTLVPEQAAVSSANFHADNAEMLGLVGHHRSSRIPTLDNAEQDKTVHDIRQSISAEPTGNIDALRKEAAEKAGKSKSPSIKEVPVVDDVAVENKEELMEPNEPKGNAIAEMLATPMPQEIKSESKDDTKGGLSPTQKSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W6QA92</accession>
    <name>W6QA92_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Tetratricopeptide-like helical</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S02g001239</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QA92"/>
    <dbReference type="STRING" id="1365484.W6QA92"/>
    <dbReference type="OMA" id="MAMIANA"/>
    <dbReference type="OrthoDB" id="5986190at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF11">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM31089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="461" mass="51252" checksum="33E1E5264F64D02D" modified="2014-04-16" version="1">MDNHPPSLESLQREVSELTAIYHGRGWTTEATELESAMTTAGNRILATRADSEGMKIMLEELAACVKTLLQANSWIVAEDLGILVLDSCEKLKGEQDLMTMTAMHNLASAYWGRGQLDQAAALASWVTKLRQKILGEEHPQTLTSMTNLASTYRSQGLWADAQELDLRVFEMKKKTIGLKHSSTLGSMSNLAISYAYLGRYEEAETIARQLVDLGESELSPTDASLLKWKLTLASTYRDQGRLDSAEKLELEIVAVSRDIFGTNDHFTLTSMANLASTYREQGRWSDAERLEKEVVASSETVLGETHPQTLMSISNLASTYRNQGRLEEAKDLGEKATTVMKEVLGERHPHTLVAMADLAVTFQMMRQSPDAEILAARSLRLMKETIGKDHPYTLNAMANLGFIYQSQSKWDVAGGMAETVYSRRERALGTDHPDTVAALEDLRRIAWVEAADQNSQRTLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W6QAD1</accession>
    <name>W6QAD1_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="7">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PROQFM164_S02g001279</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QAD1"/>
    <dbReference type="OrthoDB" id="4525967at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF2">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="92"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="95"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM31129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="120" mass="13313" checksum="3585C042F1739E55" modified="2014-04-16" version="1">MRAEGDASSTISRSVCQLLPLSKPLNYGTFIFFGLVTTIGVLHVWFLVSETKGRTLEEMDELFGSGSMAVEDEVLKRRIEREIGLLALLGEDSDSSEKTSEKLEHLDHRKRAELPNSASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W6QC31</accession>
    <name>W6QC31_PENRF</name>
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        <submittedName>
            <fullName evidence="4">Thioesterase superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S02g001865</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioesterase PaaI family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QC31"/>
    <dbReference type="STRING" id="1365484.W6QC31"/>
    <dbReference type="OMA" id="GDWMNTL"/>
    <dbReference type="OrthoDB" id="2831072at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03443">
        <property type="entry name" value="PaaI_thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.129.10:FF:000075">
        <property type="entry name" value="Thioesterase family protein, putaive"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039298">
        <property type="entry name" value="ACOT13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003736">
        <property type="entry name" value="PAAI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00369">
        <property type="entry name" value="unchar_dom_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21660:SF1">
        <property type="entry name" value="ACYL-COENZYME A THIOESTERASE 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21660">
        <property type="entry name" value="THIOESTERASE SUPERFAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioesterase" evidence="3">
        <location>
            <begin position="71"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM31714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="170" mass="18605" checksum="09DD01933F3ED61F" modified="2014-04-16" version="1">MSHNAISAPPRQLDEFEQLVYEYTARMGLGNEEHWDIDARGCNLRFESATRGPPATVSFLLTITPALTNYFGNLHGGCAATLIDVLSTTILLGVSEPGRFSFGGVSRNLKITYLRPVPAGTEVRLVCEVIHVGKRLALLRAEIQRAESGDVCVIGEHEKANTDPEVTQRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>W6QD45</accession>
    <name>W6QD45_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Homeodomain-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PROQFM164_S03g000710</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM164</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">Interacts with MCM1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QD45"/>
    <dbReference type="STRING" id="1365484.W6QD45"/>
    <dbReference type="OMA" id="KPDMDCV"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000082">
        <property type="term" value="P:G1/S transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000286">
        <property type="entry name" value="Homeobox transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051000">
        <property type="entry name" value="Homeobox_DNA-bind_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24324:SF9">
        <property type="entry name" value="HOMEOBOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24324">
        <property type="entry name" value="HOMEOBOX PROTEIN HHEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 9 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 9 10" id="KW-0371">Homeobox</keyword>
    <keyword evidence="6 9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Homeobox" evidence="12">
        <location>
            <begin position="48"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="9">
        <location>
            <begin position="50"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="38"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="99"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="332"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="9"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="125"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="196"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="244"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="332"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="351"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="378"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="453"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="465"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00065092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDM33986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="571" mass="62342" checksum="7899548123E5AB40" modified="2014-04-16" version="1">MSDPEPSVAISSSPSLPATDSNPLNYAFLVHSQKTLTQNLPPRVDNKLLARQKRRRTSPEDHAILESEYQQNPKPDKAARTSIVSRVSLGEKEVQIWFQNRRQNDRRKSKPLQPHELLAPRSGRVDSSGQPSSDDNASTEPGSSSGAEQFDINDHREEMASKPWHGGLLQFSDDSDPVTEDKDEHELPQSTQTSVATEAAGETPPTTQEEFSQLVNDPSEDPLLQIPKRKRSVSDIRGEGENEQAATTKPTQNTQNTQTTPTKSPPSLRLSMSFDGEALVHKEDELTPSPPKGRNALRIAMSSDGKAVIRGENEPSPSKNRVAMFSVRRTKMTSLQRSSSAVFPATPRAGVTEKDRAFGRSRDPRNWESFCDTDARSALSTPTSGPNGSPGLFQSRSQRSLPRSASGRHSLAAHGEPNTPISQSMGEKRRKLARAVSSLGRLETGRNKANVNPSKLSKPLFSKSGKPDLEQDLGDSDKENWVPGTRSTNIRRRNTSHIPRPVLRDANRNRGLGISANGKRNRALQAGSQGKAPPELSAEVSAFMAGGTGDSQEDDLDCVQGLLSLSQGAWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W6QDG0</accession>
    <name>W6QDG0_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ankyrin repeat-containing domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S03g000825</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QDG0"/>
    <dbReference type="STRING" id="1365484.W6QDG0"/>
    <dbReference type="OrthoDB" id="426293at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13606">
        <property type="entry name" value="Ank_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="18"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM34101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="110" mass="11945" checksum="154B7C9EBBBA443F" modified="2014-04-16" version="1">MIICFLITEPILIVDVILNSTPLSYAVEHASLPLVSLLLNRGGDITEGQVLHHAVSRNSDAVELPKLLLLDQRYHVSMPSAFLGHEFLSGGNCSAQGSISLQIRCHPFPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W6QDI8</accession>
    <name>W6QDI8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g001483</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QDI8"/>
    <dbReference type="STRING" id="1365484.W6QDI8"/>
    <dbReference type="OMA" id="GTHAAMM"/>
    <dbReference type="OrthoDB" id="4358242at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540">
        <property type="entry name" value="TRANSCRIPTION FACTOR (ACR-2), PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540:SF5">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="284"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="49"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM27672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="324" mass="36731" checksum="2ECDBB602976895B" modified="2014-04-16" version="1">MDSPNEKEPHFQFVESIEKPVARSHAMKTYWRRKKGEQQQEEYLKPNQPSLRPLRPLSKPRAVHEPETSTLLSPTEEASSGHGYLSCSVKSPEELGIPDQLFANISFTFACVLGQKVEANSFQISAHHHRFFYHWLSMHAHIIHSGLQARTFTPFTEIWMPLDLSNAASFNGILAHAAADLMRFEGGRSNPELLKYKTEAIETINKWLGDTVNAITDDVFAGVVRLLTFERHWGTRERFNMHKHGLQQMVQARGGYKAFGPNWRIQLVLSLYFLLASSIPKPVSPRQTTHTPRVIGRSDKGFATSTDNRGRHAWRDTASTGSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W6QDJ7</accession>
    <name>W6QDJ7_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Chitin-binding, domain 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PROQFM164_S03g001480</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the polysaccharide monooxygenase AA13 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QDJ7"/>
    <dbReference type="OMA" id="FWATPDF"/>
    <dbReference type="OrthoDB" id="120613at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004302">
        <property type="entry name" value="Cellulose/chitin-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052282">
        <property type="entry name" value="Starch-active_LPMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36575">
        <property type="entry name" value="BINDING PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G14430)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36575:SF2">
        <property type="entry name" value="CHITIN-BINDING TYPE-4 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03067">
        <property type="entry name" value="LPMO_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0186">Copper</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004881492" evidence="7">
        <location>
            <begin position="20"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-4" evidence="8">
        <location>
            <begin position="20"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM34753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="340" mass="34434" checksum="4A0AE19E53876EE0" modified="2014-04-16" version="1">MKSFTPALAFASIISLVNAHGFVTSPAAREPGTAMGAACGQQVLSNQESDKYGNIQGELQVAATQTDYNAAECDIWLCKGYKFADNQANIQSYTAGEEVAFTVDIRAPHTGVANVSVVQTSSNTVIGSPLISWDVYASVATGVTANETSFSVTIPDDLGSQCATAGDCVLQWYWYAESIDQTYESCIDFTLGGSGSSAVASTSSTSSTSSISSTSSSTVVAATTTPTAAVVETPTTAAVQPTTSSTTVAAVVKTPTTAAVQSTTPSITVAAQPTTSTTTVAAQPTTFATTVRQSTTSAAAQVPTTSADASATTSAVSIPTGSAADVLSWIESLLGNLVGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W6QDU2</accession>
    <name>W6QDU2_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transcription factor, MADS-box</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PROQFM164_S03g001390</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QDU2"/>
    <dbReference type="STRING" id="1365484.W6QDU2"/>
    <dbReference type="OMA" id="CCECDAD"/>
    <dbReference type="OrthoDB" id="4361034at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1810.10">
        <property type="entry name" value="Transcription factor, MADS-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002100">
        <property type="entry name" value="TF_MADSbox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036879">
        <property type="entry name" value="TF_MADSbox_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00319">
        <property type="entry name" value="SRF-TF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55455">
        <property type="entry name" value="SRF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50066">
        <property type="entry name" value="MADS_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="MADS-box" evidence="7">
        <location>
            <begin position="16"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM34665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="108" mass="12537" checksum="B4FDC38486A13671" modified="2014-04-16" version="1">MAPSSELISTITAKQDSPRARAQKVRRRRKGLFKKAAEYSINCESDVVVAVRNRQSGQLYIFESSKKKWLPAEMDMDNYYPRPITETTEDIIPCLERLEEEELRADIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W6QE54</accession>
    <name>W6QE54_PENRF</name>
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        <submittedName>
            <fullName evidence="4">K Homology domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S01g001678</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
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        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CDM27867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="1365484.W6QE54"/>
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    <dbReference type="OrthoDB" id="397265at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd22385">
        <property type="entry name" value="KH-I_KHDC4_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22386">
        <property type="entry name" value="KH-I_KHDC4_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000037">
        <property type="entry name" value="KH domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000051">
        <property type="entry name" value="Putative kh domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055256">
        <property type="entry name" value="KH_1_KHDC4/BBP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
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        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047890">
        <property type="entry name" value="KHDC4_KH-I_first"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047889">
        <property type="entry name" value="KHDC4_KH-I_second"/>
    </dbReference>
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        <property type="entry name" value="PRP5/DDX46/KHDC4_KH"/>
    </dbReference>
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        <property type="entry name" value="RIK/BLOM7"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15744:SF0">
        <property type="entry name" value="KH HOMOLOGY DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="KH_12"/>
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    </dbReference>
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        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="3">
        <location>
            <begin position="240"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
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        <location>
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            <end position="388"/>
        </location>
    </feature>
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        <location>
            <begin position="440"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="348"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="358"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="371"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="440"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="460"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM27867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="488" mass="53008" checksum="7D2FFB8846D59678" modified="2014-04-16" version="1">MADDEHRVKRSRFDQTEPEPRRSRFDQRSRSPSNRQSESARTRSPLSRPLSRTLSRSPGADTPAKPPVVDPAAAAAAAAAKINAQLQAKKAIQHVDVPPIRSADNATENSQSPSAEGAAKLNAEIYVADGDYIKDIEINDLRNRYTLTKGSTQKMIQDETGADVTTRGNYYPDKNMATAASPPLYLHVTSTNKEGLEKAVTMINDLMQKELPNLVDERRFRRREPEQQVERDEYGRRKWPDERILIDLEPIPGFNLRAQVVGQGGAYVKHIQQQTRCRVQIKGRGSGFIESSTGRESDEPMFLHVAGPDANDVQQAKELCEDLLTNVKEQYQRFKENPPQHNYGGYRGGDRGDRGDRYQGGGGGGYGGGYNNRQQHNNPSASPAGQAAAAASPSAAATPTAADYSAQYAQYYGTTDPYAPYGGYQNYVAYCQYYQQMAAAQQQQQADGSAPPTAPASETPAPPPGSGSPPPPPGAGGSYSAVPPPPGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W6QEF8</accession>
    <name>W6QEF8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S02g002740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QEF8"/>
    <dbReference type="OMA" id="MYSKPSE"/>
    <dbReference type="OrthoDB" id="4362761at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM32589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="142" mass="16175" checksum="46C4EC3D6ABA428A" modified="2014-04-16" version="1">MYSKPSEICYPTIGRIRKIPFTNQRQSFRSRLQRSAEGNTTEEESSLQENGFFGNHHNDIANLAEDCNIIALQCTADLDIRTKLIQKALDNSNSWITTIRSDLEDIRSRLAVVETAIEIIAKEGKNSTTEDNTTRRTLRSQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W6QEP5</accession>
    <name>W6QEP5_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF1279 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S01g001868</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QEP5"/>
    <dbReference type="STRING" id="1365484.W6QEP5"/>
    <dbReference type="OMA" id="TKWISRP"/>
    <dbReference type="OrthoDB" id="426386at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045866">
        <property type="entry name" value="FAM210A/B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009688">
        <property type="entry name" value="FAM210A/B-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21377">
        <property type="entry name" value="PROTEIN FAM210B, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21377:SF0">
        <property type="entry name" value="PROTEIN FAM210B, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06916">
        <property type="entry name" value="FAM210A-B_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1279" evidence="2">
        <location>
            <begin position="121"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="59"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="83"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM28057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="256" mass="28048" checksum="B81D5F485DAE455D" modified="2014-04-16" version="1">MSVRPTLLAKWISRPSSMLKSSPSLASHLQLHLNPSIRPSLARRSTIFPHAHGAQVTARFSTRTRPTPTPSSFQPKPKQRRFNSGSAGDGKNSSSGSDSGPGNGTGSRGGGKTKPKPSLSQRLKSLSREYGWAALGVYLGLSALDFPFCFAAVRLLGVDRIGYYEHVVIGYVKDKVKSVFPKTKGSEEEDGQGQLAQAEERNQEEASIWTQLVFAYAIHKSFIFIRVPLTAAVTPKVVKTLRRWGWDIGKRKPKST</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>W6QEU1</accession>
    <name>W6QEU1_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">PAN2-PAN3 deadenylation complex catalytic subunit PAN2</fullName>
            <ecNumber evidence="10">3.1.13.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">PAB1P-dependent poly(A)-specific ribonuclease</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Poly(A)-nuclease deadenylation complex subunit 2</fullName>
            <shortName evidence="10">PAN deadenylation complex subunit 2</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">pan2</name>
        <name evidence="10" type="synonym">PAN2</name>
        <name evidence="13" type="ORF">PROQFM164_S03g001290</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein PAB1. PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. May also be involved in post-transcriptional maturation of mRNA poly(A) tails.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Exonucleolytic cleavage of poly(A) to 5'-AMP.</text>
            <dbReference type="EC" id="3.1.13.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="10">Binds 2 metal cations per subunit in the catalytic exonuclease domain.</text>
    </comment>
    <comment type="activity regulation">
        <text evidence="10">Positively regulated by the regulatory subunit PAN3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Forms a heterotrimer with an asymmetric homodimer of the regulatory subunit PAN3 to form the poly(A)-nuclease (PAN) deadenylation complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">Contains a pseudo-UCH domain. This ubiquitin C-terminal hydrolase (UCH)-like or ubiquitin specific protease (USP)-like domain is predicted to be catalytically inactive because it lacks the active site catalytic triad characteristic of thiol proteases, with residues at the equivalent structural positions that are incompatible with catalysis, and it cannot bind ubiquitin. It functions as a structural scaffold for intra- and intermolecular interactions in the complex.</text>
    </comment>
    <comment type="domain">
        <text evidence="10">The linker, or PAN3 interaction domain (PID), between the WD40 repeats and the pseudo-UCH domain mediates interaction with PAN3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the peptidase C19 family. PAN2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.4" evidence="10"/>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QEU1"/>
    <dbReference type="STRING" id="1365484.W6QEU1"/>
    <dbReference type="OMA" id="TQELLWT"/>
    <dbReference type="OrthoDB" id="16516at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031251">
        <property type="term" value="C:PAN complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004535">
        <property type="term" value="F:poly(A)-specific ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06143">
        <property type="entry name" value="PAN2_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000459">
        <property type="entry name" value="PAN2-PAN3 deadenylation complex catalytic subunit PAN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000028">
        <property type="entry name" value="PAN2-PAN3 deadenylation complex catalytic subunit PAN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000135">
        <property type="entry name" value="PAN2-PAN3 deadenylation complex catalytic subunit pan2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03182">
        <property type="entry name" value="PAN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030843">
        <property type="entry name" value="PAN2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050785">
        <property type="entry name" value="PAN2-PAN3_catalytic_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048841">
        <property type="entry name" value="PAN2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028881">
        <property type="entry name" value="PAN2_UCH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15728">
        <property type="entry name" value="DEADENYLATION COMPLEX CATALYTIC SUBUNIT PAN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15728:SF0">
        <property type="entry name" value="PAN2-PAN3 DEADENYLATION COMPLEX CATALYTIC SUBUNIT PAN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20770">
        <property type="entry name" value="PAN2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13423">
        <property type="entry name" value="UCH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 10" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="8 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 10" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 10" id="KW-0540">Nuclease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="USP" evidence="12">
        <location>
            <begin position="482"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1090"/>
            <end position="1110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1141"/>
            <end position="1162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1091"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1101"/>
            <end position="1110"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="866"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="868"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="975"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="1035"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDM34566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="1162" mass="129995" checksum="C2BE5720E07C400F" modified="2014-04-16" version="1">MEADWDELSRIPMPPPSPHAMPTVATATAFDDMMELLWTGNEYGRVSSFYGPELQRYTSVRAHPVSEGAVQQIIFHERGVISLSSKSVHMITRRGLTQWHLTHDEMVDLRCMSFTAQTNRILVAGSQRVMFTVDIDKGTIVEKLPTEHGYTIMKKSRYLCAATDTGSVNALSLSDFSVVKSWKAHGTGVNDMDARNDLLVTCGFSVRHLGSPIVDPLANVYDLKTLTPLPPIPFHAGAAYVRMHPKLHTTSFVASQTGQLQVIDLMNPNSVNLRQANVSLVLGIDLSPSGEALAINDAECSIHLWGSPTKVHFNELSKETEFAEVPTRPPQVEWSSESPLNIVGMPYYHERLFSAWPSHLLFEVGSPAAPLDQSMLPYLRPAEMGHHAPNPRKTRRYQIENTRALTMAEPALIAPKFLSEKARDYSKSDGLVSDTAETLAGAKINGESDDDPLLKYSNVEIKYSRFGVDDFDFRFYNKTSFSGLETHIANSFTNSLLQLFKFIPLFRNLALNHAAGSCIFEHCLLCELGYLFDMLEKASGQNCQATNLLKTFSSFREASNLGLLEENLTNKSLSTAIQAVNRFFLTQIAQDFRMIQPNSEELDQRLATIASESIRCMFCQNEIVRPGNSLANELIYPNIDMKHARRNPLFRFSNILRASIERETQNRGWCNYCRRYQQVTIRKTIHRMPLILVLNAALTNPLCRWLPDAVGILVDASGQVMCFEGDDLRLRIQNQTPGLAVYDLIGLVAEIDIPEHQKAHLVSFVNVSISGAESEEQGKWHLFNDFLVTEVERDEALRFTQPWKQPCVLAYQVRDPRHVVDDSWKNLLDKTLLFREWSLNGGRPVESCQTLTEDEMPKPGTPVALDTEFVDLEKAEIDVKADGSQEMVRPNKSGLARVSVLRGVGVHEGVPFIDDYITIREPIVDYVTQYSGIKPGDLDPRTSEHNLVPLKVAYKKLWLLLNLGCIFVGHGLASDFRKINIQVPKAQTVDTQYLFFHPGKNRRLSLRYLAWAVFKEHIQEEPSPETVQGHDSIEDARMALRLWKKFQEYEDAGIVSQMLEEIFREGSKLGFRPPPKNGGTVAVLSRPGTAVTMQNDSGRNTPSTPDTRSVVPVTTTSAVPITGSPSAPTTPRQAFRRSIALTPSNGSFSGPGTGDFFGSPLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W6QEZ1</accession>
    <name>W6QEZ1_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WD40/YVTN repeat-like-containing domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PROQFM164_S03g001350</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1365484.W6QEZ1"/>
    <dbReference type="OMA" id="RGQCASI"/>
    <dbReference type="OrthoDB" id="248320at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008139">
        <property type="term" value="F:nuclear localization sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006405">
        <property type="term" value="P:RNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Putative nuclear pore complex subunit Nup159"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026054">
        <property type="entry name" value="Nucleoporin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039462">
        <property type="entry name" value="Nup159/Nup146_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23193">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23193:SF23">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16755">
        <property type="entry name" value="Beta-prop_NUP159_NUP214"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117289">
        <property type="entry name" value="Nucleoporin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nucleoporin Nup159/Nup146 N-terminal" evidence="5">
        <location>
            <begin position="55"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="461"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="529"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="632"/>
            <end position="1155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1405"/>
            <end position="1446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1472"/>
            <end position="1491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="463"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="534"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="561"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="651"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="666"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="714"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="768"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="783"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="967"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1004"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1115"/>
            <end position="1131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1140"/>
            <end position="1153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDM34626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="1518" mass="159353" checksum="32B6C2DAD20F53BA" modified="2014-04-16" version="1">MAFNFGASNPAGGSASAELGSELPDVFTDEVGFKGVSGDANIRFLPTAWPDNALPAPTSSLLAVAHTKGLVVGAGPDALVIGTTDVVRKSIEAPAGEDMEKTKPFQPIATIPLPSRPTHVAFTPGDDGLILATENGSTISVFDTNTLTQGNAQPAISIPTNGVSLRALAPNPEPSSTLVALVTVNGELLIADLKAGSLVPGPNGPVLKDGVSCASWSNKGKQLVAGLADGTGYQMTPDGTKKAEIPRPSDLEGDCHISSIAWLENDVFFVTYTPNVSEDDMGMNPASSYYIITRRKQAPFLIQKLPEVCSTMGFMLKRGPAFQFITRIREYKPHLRDVLIVASTASTDLGLITRSDQPLANDERTKLHVGQFMTTEVSDDTKRASVPLKDSGDETSVIGLAQNLSATENVIAPLPGSDILESSTPLPGVLLLNNDGILSSWWFVYADSIRQNIPYSGLISSGQATQAPSQPQAVAPTPAQQPAFGQSSFGGSSAFGQPAFGKPAGASVFGSPSTLGASTMGATAFGKQSAPAFGSPSRLGGSPSPAFGKPSSPALAPAFGTPSQPGASFGTPSTPGQPQFGKFGFGAIGSGQSTSPANPFGAKGVASGGAGFSAFSGGGGFSGFATAKPGESPFAAKQPGGSPFAATQSKGSPFANASSASPFGAKSQTQTSFPPQASNEVKNPFGAAQGGFELKSAFKGDGSAANDGPNADKSSSGAFSFGGSFDEMVSTPRKGSSSPSESMDDTEDIEPVNKETFSIFGGASKPASQTPTSTFSSKTTPSAENTKSAFSMFGSSADQNRVTSPLSALSDKTETPKKNWPNTSSLDVEAPLPPDPTSRASYAAGDTSASSNVSKCSAEDVPLPPDFTKAKKASPKPEEDAPLPPDFLNQKKPAPKIDDAPLPPDFLTKSKKVEAAAVPDDAPLPPDFLTKSKKVEAAAVPEEAPLPPDFTAKPKTKPSEEAVPIPDESDESGISDADSEAAAGSDFSDSGEEITHDEALIAKSKQSAQSSFDAASEQSSTGGFFDSPARNVNDKGRLPQQLFGEIPKQALLPPPVSIAKGNREPYRSPSPVRVGGKKNVLFSEKSHSRKGSTGALHSRKASLTHIAQRSGHLRKASDVAREEREEQEKQARAHAAAQIQEDDVLSLSDDDEDDRLRDELAQPVEPVDTLDPFLPHQNYMGDTPKPGIAGQVERLYRDINSMVDTLGINARSMAGFLLYQQPKKLSDIDEWVIVMNGDQPADILDTKMTFKDIERFEELIASISRSLDNQRVQGVDEKLDACRDLLTKQIVTLRGQFASIRKTLDAHTDIGAILEAPLSAEQGALQHDLRTTFTNIQVEITALEQAVSLLRAKIADIPQTNGGGRNRPTVEAVTKTIATMMSMAEGKSTDIDVLEAQMRKLGVDIVSTGPPSREGSPFSTPRKNAAGRIPMIPGSRGSIDGSAYHTPDSVSRGLNFRASINGSVRQSRLRSVEGAGEPALPQEDAIQYKANRSRRQRLNANLKKAFEDKQAKVRSVDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W6QFA1</accession>
    <name>W6QFA1_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ATP-grasp fold</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PROQFM164_S02g002950</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QFA1"/>
    <dbReference type="STRING" id="1365484.W6QFA1"/>
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    <dbReference type="OrthoDB" id="434648at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052032">
        <property type="entry name" value="ATP-dep_AA_Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041472">
        <property type="entry name" value="BL00235/CARNS1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43585:SF2">
        <property type="entry name" value="ATP-GRASP ENZYME FSQD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43585">
        <property type="entry name" value="FUMIPYRROLE BIOSYNTHESIS PROTEIN C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13535">
        <property type="entry name" value="ATP-grasp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18130">
        <property type="entry name" value="ATPgrasp_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="5">
        <location>
            <begin position="245"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDM32799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="606" mass="66790" checksum="7E3CD22013B86693" modified="2014-04-16" version="1">MPHEVCILIDDTQNVHVEIVATSLEPLQRGDINECSVLTALVQPLRREVIDKIRGLFPITRSMLVMDAGSDTPVKATLDPANISSICTCVGDQKGQQTVLFIIANREGRWSASSAPGNSSVFFQPRPMVWQNSSGWPFAASWPMSPATIPLHRLAVVGEVRPAHLSSRFFQAARALGVELVALGPRGHWLQDPESRNDPDREVFIELDLTVDPGLPHRIVTTIQDYAGEIDGLSTVTEYLLIPVAQAAERLGLPTSPSMSFSKSVNKYQTRLEDSPSSCRLVSGLDAFQSQLAYEEEGILPPGPPWIVKPCNGWHCLGATKVATKEGLVAAVERVAKYAAYSRDGPNAEDPQWQTNVLIEEYCDGLEVDCNFVLWDGQILFFEVIGNFPCAGDTVAEGMQTTENFKETQLVFSSALPPSELYTLKSSLYDAITRLGFRSGVFHVEARGGDSSNRYRAAEDDETLDLRPRPKPAARRATVFLIETNARPPGYVDTCASYYANGVDLSRALSQPFHSRPHVVVSAIQATKAGIIASEDPWKDIVQKNPTLMRSVVHHVMSFGEGHRIQNPRLDTTPWLSAFTTYSLKNRADALRLCSQVKRESECEIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W6QG17</accession>
    <name>W6QG17_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S04</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S04g000226</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QG17"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM35345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="62" mass="6750" checksum="C704A286E3DD2B77" modified="2014-04-16" version="1">MLRDKPRAILHGQCCNAPGVSPYNLESARTKRADVISLATFILALVIASSTGYCLAPARRYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W6QG92</accession>
    <name>W6QG92_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PROQFM164_S02g003361</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM33209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QG92"/>
    <dbReference type="STRING" id="1365484.W6QG92"/>
    <dbReference type="OMA" id="KWVITIM"/>
    <dbReference type="OrthoDB" id="446368at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF47">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="141"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="165"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="200"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="234"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="307"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="343"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="386"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="411"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="444"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="479"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="76"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="49"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM33209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="516" mass="57398" checksum="DA293D3D2E49CD0D" modified="2014-04-16" version="1">MPSKETQTLLSSHSNQSERESTSLQTVFDDGDTYDVADGLESNGGSSKIKPERSPNEKDNLIEKPKNFPTWRKWVITMVLGMMTLCVTFGSSIFTTATRQTATKFGVSMEVTLLAVSLFVLGFAFGPIIFGPLSELYGRKLPLFLGMFGFAIFQIPVAVAENLHTIFICRFLGGTFASAPLAIVNGILADMFEPVERGIAMAVFAAAAFIGPVAGPIVGGFITISYLGWRWTEYITAIWAFAISSIGILVVPETFEQTLLTQRAKRLRTKSKNWALHAKAEEKVVSYQDIAVQYLLRPFQMLVQEPILLLITLYMGFIYGFLYTCFVAYPVSFQEQRGWNDGIGALPFVAFICGVFCGCLIIIAFSLTRYRTFILRNGRVQPEERLIPMIIGGILLPVGMFWFGWTSDPHIIWVPQVISGAFLGSGVLLIFLQGLTYIVDVYPMYTNSAMAANSFFRSWLGAGFPMFAPPLFHNLGVDWAMTLLGCLTVALFPVPIAFFIYGPKIRSWSRFTMKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W6QGF4</accession>
    <name>W6QGF4_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Short-chain dehydrogenase/reductase 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Retinal short-chain dehydrogenase/reductase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PROQFM164_S04g000386</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the reduction of all-trans-retinal to all-trans-retinol in the presence of NADPH.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QGF4"/>
    <dbReference type="STRING" id="1365484.W6QGF4"/>
    <dbReference type="OMA" id="DQIQMSL"/>
    <dbReference type="OrthoDB" id="10253736at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052650">
        <property type="term" value="F:all-trans-retinol dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000131">
        <property type="entry name" value="Short-chain dehydrogenase/reductase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24322">
        <property type="entry name" value="PKSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24322:SF736">
        <property type="entry name" value="RETINOL DEHYDROGENASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00059620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00068717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00082544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDM35505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="316" mass="35371" checksum="C684BFF482DD7AB8" modified="2014-04-16" version="1">MFNLLDTPIIKSSLSVLVGSVGLYYLNTKISERVINNFQGSEAWIPENELVLLTGGSGGIGREIMEDLSRNKVRVVVLDIIRPTFELPENVTFYQTDVTSAKSLSEAGAAIRKAHGEPTVIVNNAAIFHHDTILDLPEEQLRQAFDVNIISHFLIIKEFLPFMIRMNRGHVLTVASVASFVTLGEMVDYACSKAAALSFQEGLRQELKYWYKAPNVRTSTIHPLWVQTPMIEGFTKYQAAFDQPLLDPKDVSQAVVEHLVNRKSGLTVLPRHSSVIGSLRAFPLWLQEAVRSYFSSFVMRVRIQRTADENSGSHVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W6QGX0</accession>
    <name>W6QGX0_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Biogenesis of lysosome-related organelles complex 1 subunit KXD1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">KxDL homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PROQFM164_S01g002663</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1) involved in endosomal cargo sorting.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the KXD1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QGX0"/>
    <dbReference type="OMA" id="DRMQDVF"/>
    <dbReference type="OrthoDB" id="4089816at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031083">
        <property type="term" value="C:BLOC-1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032880">
        <property type="term" value="P:regulation of protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051390">
        <property type="entry name" value="BLOC-1_subunit_KXD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019371">
        <property type="entry name" value="KxDL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37787">
        <property type="entry name" value="BIOGENESIS OF LYSOSOME-RELATED ORGANELLES COMPLEX 1 SUBUNIT KXD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37787:SF1">
        <property type="entry name" value="BIOGENESIS OF LYSOSOME-RELATED ORGANELLES COMPLEX 1 SUBUNIT KXD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10241">
        <property type="entry name" value="KxDL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="KxDL" evidence="9">
        <location>
            <begin position="83"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="22"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="157"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="42"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="158"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF10241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDM28852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="180" mass="19776" checksum="ECD9A512F66393DC" modified="2014-04-16" version="1">MATQRHYYQPAAYPYHHAPSKAPAPASLYPISRVSSSPPDFSDASTTAGSRSSGGLTFSSAGEYDSSFASYSGVDVVDVLSDRMQDAFDPTQLDKGLARQAQTSGQLNAKQQELLELQALAQRRLKGARANFSEGLKTARETKRDLEWTQKRVSALKAKAEKAHPDEYRRSSKKFAHDGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W6QGX9</accession>
    <name>W6QGX9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Hydantoinase/oxoprolinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PROQFM164_S01g002673</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxoprolinase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QGX9"/>
    <dbReference type="STRING" id="1365484.W6QGX9"/>
    <dbReference type="OMA" id="GTGPQMW"/>
    <dbReference type="OrthoDB" id="3643at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017168">
        <property type="term" value="F:5-oxoprolinase (ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008040">
        <property type="entry name" value="Hydant_A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002821">
        <property type="entry name" value="Hydantoinase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003692">
        <property type="entry name" value="Hydantoinase_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045079">
        <property type="entry name" value="Oxoprolinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365:SF2">
        <property type="entry name" value="5-OXOPROLINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365">
        <property type="entry name" value="5-OXOPROLINASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05378">
        <property type="entry name" value="Hydant_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01968">
        <property type="entry name" value="Hydantoinase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02538">
        <property type="entry name" value="Hydantoinase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydantoinase/oxoprolinase N-terminal" evidence="4">
        <location>
            <begin position="9"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="Hydantoinase A/oxoprolinase" evidence="2">
        <location>
            <begin position="241"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="domain" description="Hydantoinase B/oxoprolinase" evidence="3">
        <location>
            <begin position="738"/>
            <end position="1267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDM28862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="1270" mass="137546" checksum="F9325BEBFA3EF812" modified="2014-04-16" version="1">MTTAPGINISIDRGGTFCDVLVQIPGRDDLVFKLLSEDPQNYRDAPTEAIRRALEIIENRQIPVGEKLDGSRIASCRIGTTIATNALLEGKGRDFAFVTTKGFKDVCVIDDQTRPKLFALNVRKPPALHSTSVEIDERITIEDYDLNPFPSDKAAKLTDPALVRTPSGEVIRVLKALDPVEVREVLSGLQSAGYTSLVISFMHSYLYSGHEDQVADIAQDMGFETVIKASEVSPVIKFLQRSSSASSEAYLYPIVRDYIKAFQTGFSVLPQRVEFMGSDGGLRQADKFRGNEALLSGPAGGVVGIARTCFDAAEGTPVLGFDMGGTSTDVCRYDGKYDYLTETTVGGRKITTPMLNIATVAAGGGSMLFARHGLFVVGPESAGAHPGPACYRKGGPLTVTDANLFLGRLVLSSFPGIFGPNANQHLDLDVTKQKFDELTREINEQTGQKLTPEEVAFGSLDVANETMTRPMRNATEVRGFAPSSHTLVSFGGAGGQHACSIASKLGITRILIHKHSSLLSAVGISQADLQVEKTVPFVGSFDFKVLDDIRAHISNLKSQAESALLSQGADPSTVVFEESLSLRYTGTDTNIVVPKPKDEDYGASFIATHLREFAFVLDRKIQIDSIKVRGVGRSGVAIEELSPYSQLEQVKSLNDYLQADRTQSVYFDSEWQNVPIFELASIRRPSQVRGPALLIDATQTIFVESNFDAFLLPNHLVLEKSETKTPSNTEVAQSETIDPIQLSILSHRFMAIAEQMGYTLQRTSISTSIKERLDFSCAIFSREGKLVANAPHIPIHLGSMQYAIQYQHRLWEGKLKAGDVLLSNHPECGGTHLPDLTIITPVFVDGETTVAFYVAARGHHTDIGGQGITSMMPDSKELWQEGFNVRSMKIVDNGVFLETDVRNAFLAAGDLPGCSPSRRLDDNISDIKAQISANQRGILLLQKMCAEFTFPFVDRYMNAIQRNSETAVREYLKSVSQTRTMPLTASDHFDDGTVIKVSISIDEAGGAVFDFTGTGPQMWGNYNCPISITHSAVIYSVRCLLDADIPLNDGCLSPIDIRIPKGSVLRPSASVAICGSTLASQRVIDTILRAFESCAAFSGCANSFGWGMGGRNPATGIIEPGWNYGETVGGGCGAGPGWHGEHAIQAHSTNTKITDAEVVEKRTPVIIRKHAINPNTGGDGEYRGGNGAVREIEARIPLKFSILSDRRVFSPYGMNGGQPGSVGKNYAFKWNEEKTALERLSLTGKAALALQAGEIMQINSPGGGGWGVHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W6QHB3</accession>
    <name>W6QHB3_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Amidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S01g002818</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QHB3"/>
    <dbReference type="STRING" id="1365484.W6QHB3"/>
    <dbReference type="OMA" id="DGWDWDY"/>
    <dbReference type="OrthoDB" id="566138at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42678">
        <property type="entry name" value="AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42678:SF37">
        <property type="entry name" value="AMIDASE C869.01-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004882039" evidence="1">
        <location>
            <begin position="21"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="domain" description="Amidase" evidence="2">
        <location>
            <begin position="83"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM29007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="584" mass="62874" checksum="2B210CA4B12EC51B" modified="2014-04-16" version="1">MAPLIQTLVSGLALVSSVIAQESDCLVDSQILVDPYLYDFPRLGGNGAAQFAMRPCHGFKLEEATIDQIQAELKNGTFTGVQLLECYMDRVHQTQPYLNAILQVNPDAFTIAKKLDEERAAGTVRGPLHGIPFIVKDNIASKDRLETTAGSWALLGNVVPRDSHVVHGMRKAGALLLGKAALSEWADMRSNNYSEGFSARGGQCRSAYNFTVNPGGSSTGSGVAVAANLVPIALGTETDGSVINPAQRNSIVGIKPTVGLTSRAGVIPESTHQDTVGTFGKTVRDAVYALDAIYGIDPRDNYTSAQEGLTPVGGYTQFLSNQTALKGAVFGIPWKSFWALGDADQIAQLLDLVKLIESAGATVINGTELPHYKEIVSPDGWNWDYGTTRGYSNESSYSYIKVDFYNNLRDYLSEVENTNVRSVEDLVQYNIDNYGSEGGLPGIHPAFGSGQDGLIASLESKGIMNETYFQALEFCRRTTREEGIDAALKHGNRTLDGLLVPPDVAQSVEIAAQAGYPVITVPGGVSDVSGMPFGLAIMNTAFSEATLIKYASAIEDLKKNHGAKYDRALPEWRGYLQRPLPVAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W6QHK7</accession>
    <name>W6QHK7_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S05g000101</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QHK7"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM36268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="110" mass="12536" checksum="223CB0A484595D32" modified="2014-04-16" version="1">MVLAWASSCLSFLWGEKWRKSATLLLCPRFYFRARDSTFVSATLLLCLRLYFCVCGCTFVSATLLASFLIATAENDPSCELESLSYNRWLSLSNYFGYSTVLIKRRDAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W6QHX3</accession>
    <name>W6QHX3_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="11">TRP-like family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PROQFM164_S05g000236</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transient receptor potential (TRP) ion channel family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QHX3"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="P:fungal-type cell wall biogenesis"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="InterPro" id="IPR010308">
        <property type="entry name" value="TRP_C"/>
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    <dbReference type="InterPro" id="IPR040241">
        <property type="entry name" value="TRP_Flc/Pkd2-like"/>
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        <property type="entry name" value="DUF907 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_2G06100)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_7G01610)"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF06011">
        <property type="entry name" value="TRP"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF14558">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01320">
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    </dbReference>
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    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
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            <begin position="20"/>
            <end position="710"/>
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        <location>
            <begin position="340"/>
            <end position="372"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="393"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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            <begin position="419"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="481"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="507"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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            <begin position="538"/>
            <end position="557"/>
        </location>
    </feature>
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        <location>
            <begin position="569"/>
            <end position="598"/>
        </location>
    </feature>
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            <begin position="21"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="650"/>
            <end position="710"/>
        </location>
    </feature>
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            <begin position="688"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00010642"/>
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    </evidence>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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            <dbReference type="EMBL" id="CDM36403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="710" mass="77618" checksum="228079EA5DD151A3" modified="2014-04-16" version="1">MQNFIWALLGLAMVPQALASDVLSTDGFDLCMTDSAINVQKMDVTYTRSTGVVVFDLAGTNAMEQNVSATITVTAYGSQLYSKEFDPCGDDIHVAELCPVPKGSFKATGSMDVPSAYASQIPGIAFTMPDLDGQAKLVLKSKQSQSNLACIQSELTNGHTTNVAAVKYVSAGIAAGALALSGVSAIGSAGTVGSPSSSPGFGDVMGWFHSMATNGMLSVAYPSVYRSFSSNFMWSTGMIPWPGLMKSIDQFRAATGGNLTDESYEFLLNSSTTQSSSSSTNTTKRSWEYTIQFGEMVARSVDTSTDASVSNSSSTESTSTSKITDLKQVAEELMVPSADVFMTILVIFAIVIAVVVVGILLMKVILELWALYGNFPNKLSDFRKDYWGMMARTITNMILVLYSIWVLYCVYQLRKGDSWAAKLLAAITLSLFTALLLFFAIRIVYMARKYKKAEGDTSRLYEDKETWKKYSLFYDNYKKDFWWIFIPVIMYALVKGCIIAGGEGHGLFQSAGQLACEVLLLGLLVWSRPYATKASLGINIAVQVIRVLSIACVLVFVEELGMSQTTKTVTGIVLIVVQSTLTAVLAILIAVNAFISCYRENPHAKRRREAEKANRDIDDLTPLDARDSLLMEHPQRKQYAEMSNFNFTGPYQTYRDEPKRAGSPGNTERDRLVNNDYGVAHARSSSPDSRHSRSSLEGRRPAAPGYGMAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W6QI08</accession>
    <name>W6QI08_PENRF</name>
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        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S04</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">PROQFM164_S04g000527</name>
    </gene>
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        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
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            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792018">
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="W6QI08"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM35646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="154" mass="17305" checksum="A3C136BBAFC0F315" modified="2014-04-16" version="1">MDFSLNFQSLHDRLNLAELDLLLLQIGTTLSFTEGPNRGLRKEPDAFLHTPSQAFPTLVAEVGWSESGNRAIKIGILVKWTKHANNSVSGVLELYRNDRQGIPRCTQTEIISPMPAGDPPQSLDIQRYEIYPVQSLRGPKEISPLEISRLRFHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W6QIF0</accession>
    <name>W6QIF0_PENRF</name>
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        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g003164</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29352.1"/>
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    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42064">
        <property type="entry name" value="YALI0F28677P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42064:SF1">
        <property type="entry name" value="YALI0F28677P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
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            <begin position="1009"/>
            <end position="1040"/>
        </location>
    </feature>
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            <begin position="1077"/>
            <end position="1100"/>
        </location>
    </feature>
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        <location>
            <begin position="1216"/>
            <end position="1254"/>
        </location>
    </feature>
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        <location>
            <begin position="1307"/>
            <end position="1368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1014"/>
            <end position="1029"/>
        </location>
    </feature>
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        <location>
            <begin position="1307"/>
            <end position="1316"/>
        </location>
    </feature>
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        <location>
            <begin position="1356"/>
            <end position="1368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM29352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="1564" mass="175371" checksum="3B339EDBA8B83223" modified="2014-04-16" version="1">MVEHQEDHSSSLHSTTTEQIPTFPKVNTPCPLSYRAQDPASVPLPPSPPGSPVMSPTFVKSPLNVGPGELGGSGRASATVVAAPSNGHNPIPAMASIIPVPVEDVPQISFEDFATRYHQNQRKQAQRKRLEKRLRATKVSIGVSARMVRVGLTAQRGLVEALRHDDKASFVALYHTLQDLQESCSAPAPNDGQTEDSMDGEPSLGTDIGRFPDFLHQLSPQSRTDFLEILRLVRSDPQFLVDRLQSLSSSQLAAFTSPATALDTNDPAFPSTSRARAQSFLNKSQTQSTAFKDHAYAFERTDPLSVLLFNVFAAPLDPGTSEARLRMEVWSSVCAQLMSNGSSRYYPLIGQILSSWTTDSTWKARSKFELYLMDILQTGAFLLEPIATPPGLDFAMDSLDPMRTDVAEEFFASAVDGLFSVLDDPDGGFPHAVLQFARAVLRKLNNPETRRRFLEFLFLQWFFSKFLYRALTYPETHGLLLDFHIRKDAREKLLNQVGHRAYAQVFAVMRSMNHFSPPRPIIKDSIENMLSRFHDAMPSKVSIDPSIRSSQAPLRRKSSSTFLMMSALDVLTLLDTLFQQTPSSLHSSPASAGVNSWPSSPPSFNLRPDSLTDSGFARFKHDTSSKHTSNIGSIFSMETHSLFPPENSLSEKAARIRFELTDLDHPNERLSLEHPSDEHWTIFSVAADGHGLTWSLLPDSRYETSKGPIIESEDDTQSTTLGLEENHEALQTAILRLVQENRIQDVGDYEFVSRNTTQPAAMSLKQRFNEAMFCCHHDSDFVGAHYWWNASQQLGQRGIPSSSRSTDDSWILGPMHENYSRSLIQSRAVIERCESDFVSLDHSLCRLQTQVKDLTATFCKIRDKMWYMSDVKNSIRYEEAKHVAMALKAMIYSARLFNQYPEEQRSRYGTRSLGGSLFQKPEVQVMNMMKAPSSQGGPNKLSDEQVELTQKWLSHNGIDNFCKGEERIHRFCYEVRMSINKLVGETMTETPVLWASELFQTERSKYEGYSRTFPGMSMPSTPRPSTTTSEDTNSASHFYGANIPLLDPTSRLSPDIPSLGHKPSFQSIISDKWRPQRDLPSVDMSSLGGSPGRAASTSTGDTYSTFWSAPQKHPMYAASASSVYSRPPSMFSETATRQPRRVERKPHGKTVFMDDLRQTLTSLLLSDLGSPVWSCGSETDAWFTNALNQKRIQVEMRRRAAVQKFYVDYDERSQHLGQQRGSLKGRRSRSMGNLRESQHKAPRVEPSSQLPQTFMESDGQSAFSYKAVFRRLIEVFSRHGNPFVKLNALRDLRSLVVASLISPQDANCPTDINSSPGEGERMRSSPQLHRATRHSFSEVRPNNLPQMDPLLPSSPPESVTCGSRRSDYSTPSEAQIVAALRDLILEMKPKTLFRDLQFISAFVPGDQLNKTDCGTAFLQFGLAALSLKEEICHSMVEIADRIVFQELSRRHTPFASDFQSRPGHAIQDAAGMWIITAKEGNPVAQRELAILYLTHPELLPRVTLPLTLPRDTFKAEMMYRRDKDSKSDPQSMCLALHWMQLSASGGDTLARNRLREREEFDSIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W6QIQ3</accession>
    <name>W6QIQ3_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S05g000531</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QIQ3"/>
    <dbReference type="STRING" id="1365484.W6QIQ3"/>
    <dbReference type="OMA" id="EGWSHNF"/>
    <dbReference type="OrthoDB" id="5404323at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="318"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="380"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="383"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="458"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="507"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="536"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM36698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="580" mass="63668" checksum="1B1DB76BA2271B79" modified="2014-04-16" version="1">MLLNLGLTADAAAAHANEPKKPEAKPSTCTTYSPAFLLSALPLLNSFYSPPRLPDGSTDCPGLVSAMTMDSIESASDSGEPSRESAMVARPRVARSNTGRKSRPKTLYQFAHPAAHARHKRFRFRPKLLLQLQQVSQTPRPLPVVDILPSTSYLPLLARKFPAIYRTRNGLGPYDLIVVLSEQYDRAVDSIPEKRVSSEDEDEDHREVVATVCQKYQGDARMNGKAEICLNFGPIWEAAPLPSGSYEFVAQTDSGVQVVRWALRGGRNRRMTMPTATQSREDGKRFTFSVIDPTTRRHPVLASMTRNQLEVNNEYSTAVRSGTGPTTPSSGMSVVSDASDETPLDGSSVILDDGLRTLIVVTGIWVAFREGWSDNFRYSDPVSSPAKSSTSPTSAKYASPTTSKNETDSFPNVAEDGKRCLSVSSVRRSQIMDGGSLSRRSNSTGAAFMDRAKRRSASGLSTRLNRHSMFTTSGENGRDIVVSRPPSPRPPSAEVEDSSRAVYPRAKSPEKAQPERETVRSKPRPDRDPPASNSHLMHHNSTRKKKSDAPLPGAVDSTKSKLSRRLSTFFGIFHRKHDTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>W6QIV1</accession>
    <name>W6QIV1_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">DSC E3 ubiquitin ligase complex subunit A</fullName>
            <ecNumber evidence="4">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Defective for SREBP cleavage protein A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">RING-type E3 ubiquitin transferase dscA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">PROQFM164_S03g000868</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalytic component of the DSC E3 ubiquitin ligase complex which is required for the srbA transcriptional activator proteolytic cleavage to release the soluble transcription factor from the membrane in low oxygen or sterol conditions. Required for growth during hypoxia and triazole drug susceptibility, as well as for virulence in a murine model of invasive pulmonary aspergillosis (IPA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 26">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Component of the DSC E3 ubiquitin ligase complex composed of dscA, dscB, dscC and dscD.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4"/>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QIV1"/>
    <dbReference type="STRING" id="1365484.W6QIV1"/>
    <dbReference type="OMA" id="LEGWMRF"/>
    <dbReference type="OrthoDB" id="9984778at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044695">
        <property type="term" value="C:Dsc E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000626">
        <property type="entry name" value="Transmembrane ubiquitin ligase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021319">
        <property type="entry name" value="DUF2921"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050731">
        <property type="entry name" value="HRD1_E3_ubiq-ligases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22763">
        <property type="entry name" value="RING ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22763:SF162">
        <property type="entry name" value="TRANSMEMBRANE E3 UBIQUITIN-PROTEIN LIGASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11145">
        <property type="entry name" value="DUF2921"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="13 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 22" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 21" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 19" id="KW-0863">Zinc-finger</keyword>
    <feature type="signal peptide" evidence="22">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004879863" description="DSC E3 ubiquitin ligase complex subunit A" evidence="22">
        <location>
            <begin position="23"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="387"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="418"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="445"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="554"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="581"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="611"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="23">
        <location>
            <begin position="737"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="478"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="491"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="20">
        <location>
            <begin position="531"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00056116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00063126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00071072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00077885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00082128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="CDM34144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="807" mass="91014" checksum="14FA243FE7349F0A" modified="2014-04-16" version="1">MDNRGSFFFFVLVFYLLFSSQSRPPLIDEDRARQRELDHERQVLRLLNGSKYGDFDPPANRWLPFSGSRGNDSYAWDLFPQVKGLARHQLQSAVSNAGLESPDGLEDPIVSPTLNLTKLLLPIYRNSTGKLRGDWVRRTEGVHRREPLNTTAIAEEHEYFTHEFSHNITGNSGTFYFDLEEGGGEELQMGDGLLREMRASLTVESEDFWGSTWYISLLGVHFPDTGSIVLTTSSEKFGGIFSLPHFMLSSDTYELSHELLLKSLSDTISEKQNRPPTLFPWSSLTGTEQMEFPAPKCEHIIYLQQHPVMLEDAVADRLLLERMEQELRYPMGAPIPDPPLMVMSAVVFSPDCGYILQTKGTPEFPPSDALYVTGPKHEEYSKYASRLIFVVSGVFVAQITLLLRQIKEASTPSTRSRISFYTIALMALGDAFVLTFIVLELYAAVSFLVLVTASFLAFLSVSYIGMKFMMEIWAVQEPERREQDRPPNPSTPTTRPGTLPLPATASEARDSGATPIILSPDQDAPDDEMDSPPPTTRATPPTPRQIRSDVGTMYARFYLTLFGMLILSIWAFLLPRRLGSIYTRFLAAVYLSFWVPQVYRNAMRNCRKALRWDFVAGQSVLRLFPFLYFLTARGNVLFIRPDYTSAFIMTGWVWIQAWILVSQDVLGPRFFVPRGWAPHAYDYHPMLRDLSGADEDLEAGGGVLSIASLRGDERDLVSDSKDDDKQRKDRKKAIFDCAICMQDIEVPVLPAPSASGGSSVTDGAASILSRRLYMVTPCRHIFHTACLESWMRLRLQCPICRESIPPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W6QIY1</accession>
    <name>W6QIY1_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S03</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S03g000903</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QIY1"/>
    <dbReference type="STRING" id="1365484.W6QIY1"/>
    <dbReference type="OrthoDB" id="4354667at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM34179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="92" mass="10606" checksum="43E3AB57A8F1D7D7" modified="2014-04-16" version="1">MPNYTDSAPHAWFVQQLTRWNINGQLMPDEHLNVMVTASPRVTASNPPYTGDQKEPDTFISCFRLPYLHEPRIIIEVGFNQTYRSLVDDAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W6QJI0</accession>
    <name>W6QJI0_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pleckstrin homology-like domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S05g000796</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QJI0"/>
    <dbReference type="STRING" id="1365484.W6QJI0"/>
    <dbReference type="OMA" id="MSWYEDI"/>
    <dbReference type="OrthoDB" id="5598057at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd13311">
        <property type="entry name" value="PH_Slm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046868">
        <property type="entry name" value="BAR_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046869">
        <property type="entry name" value="SLM1/RGC1-like_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043453">
        <property type="entry name" value="Slm1_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31941">
        <property type="entry name" value="CYTOSKELETAL SIGNALING PROTEIN SLM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31941:SF16">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE-BINDING PROTEIN SLM1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20400">
        <property type="entry name" value="BAR_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20399">
        <property type="entry name" value="PH_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="3">
        <location>
            <begin position="406"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="551"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="579"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="42"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="65"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="581"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="622"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="633"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="672"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="698"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="714"/>
            <end position="734"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM36963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="796" mass="87481" checksum="10E3D2EB0C481520" modified="2014-04-16" version="1">MAMAARPQTPSQDAYMVPQIDPGALSRGSGALESSQVPHNPRFKEDFDTVSHRSSAFDRPGVQRSVSTMSHVQSSSPSRSSTLRKKASLSKKGSLRRSGSRRSMRAGSVRSLSLGDREKYHADGAEDVNSAFLTPVPTNGNPTEVLANRFGAWRKLLKDLILFFKEVQKSYETRAKLFLSASSVVNNQTLPPGLLQPGGLADATEILQNFHRQGYTEANKAVEVEVEVISQLTGLRSDLQKKTKEIKSLSADFKNTVDKEVDGTRKAVRNLQEALGLVDTDASATSGKGDPFILRLGVEKQVEKQIEEENYLHRAFLNLENSGRELEGIVVSEIQKAYNAYASILRREANEALDTVEKLQAGPISMPQDFEWNQFVADTEELVDPRIPLRDVESITYPGKDHPAAAEVRAGMLERKSKYLKSYTPGWYVLSPTHLHEFKSADRVAWQTPVMSLYLPEQKLGSHSQEDSSSHKFMLKGRQTGAMHRGHSWVFRAESHETMMSWYEDIEGLIGMTGEARNAFVRQHVRSVSGRSVNEVMEDDEADRTPYAAESAVMTHDRPTSSRQAGGAFPSDVQLDRNLQAPLSPSSGDSSAGRDMLGAAGSLPDGSSAFNDSLRPVGSGDGRNSYQSYRSNDGTDERSRPDSNQHDSYYGDWIGPSVAVAKKRQSQQLEPPNRDDRDIRSDGDQASLAAVSGVGISNRRDQSAPAQIDRRESVSTVPTNTNATEFTNHTNPTSVDDHELDLPKIQTVGLGNGPIHQGLESDSVAKVPILLRSNTDNSIALDMKMPGRYPRTNVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2024-10-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>W6QJK0</accession>
    <name>W6QJK0_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S05g000433</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QJK0"/>
    <dbReference type="STRING" id="1365484.W6QJK0"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM36600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="56" mass="6362" checksum="E91185D52283185B" modified="2014-04-16" version="1">MSNAFFADCDIDDFRNDMHLGPSAHRLMAAEIYHGIDGIMLNPNGTEKRHNRRFAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W6QJM0</accession>
    <name>W6QJM0_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Zinc finger, U1-C type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PROQFM164_S05g000846</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM37013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QJM0"/>
    <dbReference type="STRING" id="1365484.W6QJM0"/>
    <dbReference type="OMA" id="QMRPPLM"/>
    <dbReference type="OrthoDB" id="76567at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030627">
        <property type="term" value="F:pre-mRNA 5'-splice site binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000395">
        <property type="term" value="P:mRNA 5'-splice site recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013085">
        <property type="entry name" value="U1-CZ_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017340">
        <property type="entry name" value="U1_snRNP-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31148">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31148:SF1">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06220">
        <property type="entry name" value="zf-U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="U1-C C2H2-type zinc finger" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="169"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF06220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDM37013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="211" mass="21618" checksum="9493C6B725A080AE" modified="2014-04-16" version="1">MSVRKAHNSGRNHLRNVVDYYQQIGQEKAQSVIDSITSSYAAEGQQAPNMMAPSAFPPPFGFPGMTMALPPGTPEHQPETEIKLTPLGQPGMPPPPFGIPPPGAPGAPGMLPPHGLPFPPPFPNATGTPPTGGFPPPLPNMPQGANFPIPPPGGFPNFPIPPPGVAGFPPIPGQHGMAPGGPSPIPTGPRGLEGYPPPPGGGPPGGMDQRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>W6QJT4</accession>
    <name>W6QJT4_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphatidylinositol 4-kinase</fullName>
            <ecNumber evidence="7">2.7.1.67</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PROQFM164_S03g001208</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19877"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58178"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.67"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="7">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Vacuole membrane</location>
            <topology evidence="7">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the PI3/PI4-kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.67" evidence="7"/>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QJT4"/>
    <dbReference type="STRING" id="1365484.W6QJT4"/>
    <dbReference type="OMA" id="NWMVKVD"/>
    <dbReference type="OrthoDB" id="3349449at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004430">
        <property type="term" value="F:1-phosphatidylinositol 4-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039756">
        <property type="entry name" value="Lsb6/PI4K2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12865:SF1">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 4-KINASE TYPE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12865">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 4-KINASE TYPE-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 7 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="9">
        <location>
            <begin position="168"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="313"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="414"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="630"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="16"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="439"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="649"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="665"/>
            <end position="679"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDM34484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="771" mass="87303" checksum="DB7F93C036C1689B" modified="2014-04-16" version="1">MPKTRPATSGYARLAQAEEERGYLHDESEDEDVGAFSTASTSAPRYAPVSSRAQMQASGLHTPPAHRRRHSGYTQGRRNSGVDIKAINARLEKWADEIASKFKINRVKGKSYEEEKLEIYHSVFQAPPGVIPVTAEALESDEFEGQQRRARAEYEEIIESVRLAIEMDIHPRMISQGSSGSYFARNPEGKVVGVFKPKDEEPYASRNPKWTKWLHRNLFPCFFGRACLIPNLSYVSEAAAYVLDARLRTNLVPYTGIVRLSSRSFFYDFWDRRKAWKGKKVLPPKAGSFQVFLKGFKDANIFLREHPWPDQVNTGFRTSDAPKRKKRPWNEACRPSGAQSDDEDDDPGYVPSPDGSRDESAERRFYWTENLKQSFREELEKLVILDYIMRNTDRGLDNWMVKIDWGTEQVSIVAEPPKQTSPQPKHDEDELMPPARPVSVNSNGTSNPSFHPYRRHETMMAISRTGTPLASSEQSASVQLGAIDNSLSWPWKHPDAWRSFPFGWLFLPVSLIGQPFSQRTRDHFLPLLTSTAWWSGTQMALRGVFSQDDDFKESMFARQIAVMKGQAWNVVETLKQPDHGPLELTRRTRVCVWDDLVDVPVAIPMRAPSTDKQRNQHIRNQHMNYDPDEEEMDIGASASSQPIPEHDLLGLNSSLSDLPNPNRFELTRGRTDADSERADGSIGSPATINDFGGRNTRGSLDGWPSHSRQHKNRKNGGAVPFRVPHVNTFGSDDLEGDLGYAVAEGMEGNQRKVIVERLEAVKSKNPVFTWC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>W6QJW1</accession>
    <name>W6QJW1_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein-serine/threonine kinase</fullName>
            <ecNumber evidence="8">2.7.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PROQFM164_S06g000068</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-seryl-[pyruvate dehydrogenase E1 alpha subunit] + ATP = O-phospho-L-seryl-[pyruvate dehydrogenase E1 alpha subunit] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23052"/>
            <dbReference type="Rhea" id="RHEA-COMP:13689"/>
            <dbReference type="Rhea" id="RHEA-COMP:13690"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the PDK/BCKDK protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.-" evidence="8"/>
    <dbReference type="EMBL" id="HG792020">
        <property type="protein sequence ID" value="CDM37108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QJW1"/>
    <dbReference type="STRING" id="1365484.W6QJW1"/>
    <dbReference type="OMA" id="NEMPSIC"/>
    <dbReference type="OrthoDB" id="241648at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004740">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010906">
        <property type="term" value="P:regulation of glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16929">
        <property type="entry name" value="HATPase_PDK-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000065">
        <property type="entry name" value="[Pyruvate dehydrogenase (Acetyl-transferring)] kinase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.20">
        <property type="entry name" value="Alpha-ketoacid/pyruvate dehydrogenase kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036784">
        <property type="entry name" value="AK/P_DHK_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018955">
        <property type="entry name" value="BCDHK/PDK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039028">
        <property type="entry name" value="BCKD/PDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11947:SF3">
        <property type="entry name" value="[PYRUVATE DEHYDROGENASE (ACETYL-TRANSFERRING)] KINASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11947">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10436">
        <property type="entry name" value="BCDHK_Adom3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69012">
        <property type="entry name" value="alpha-ketoacid dehydrogenase kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="10">
        <location>
            <begin position="303"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="109"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="118"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDM37108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="437" mass="49551" checksum="93949EB48085E0D9" modified="2014-04-16" version="1">MWKPSERLMDTIRHYASFPATGVSLRQMVQFGDRPSTGTLFRASQFLSEELPIRLAHRVQDLGELPDGLSEMPSIKKVQDWYAQSFEEIIALPRPTLTQEVKARLLRPGRMNGPSKILSETTQNPSVREGQYRSSVTASNGNGVARSPAASGRRYFFPSDDRGNWPPELNDYNQRFAKTLQQIKRRHDGVVTTVAQGILEWKRARQRMQIDSTIQSFLDRFYMSRIGIRMLIGQHIALTEQTHVKHPNYVGIICTKTNVRDIALEAIENARFVCEDYYGLFESPKVQLVCKEDLNFMYVPGHLSHMLFETLKNSLRAVVEAHGADKDEFPVTKVIVAEGKEDITIKISDEGGGIPRSSIPLVWTYMYTTVEQTPNLDPDFDKNDFKAPMAGFGYGLPVSRLYARYFGGDLKLISMEGYGTDVYLHLNRLSSSSEPLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W6QKG6</accession>
    <name>W6QKG6_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Guanylate cyclase activating protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S03g001439</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QKG6"/>
    <dbReference type="STRING" id="1365484.W6QKG6"/>
    <dbReference type="OMA" id="YVFIAPY"/>
    <dbReference type="OrthoDB" id="5427350at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053143">
        <property type="entry name" value="Arylsulfate_ST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039535">
        <property type="entry name" value="ASST-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35340:SF9">
        <property type="entry name" value="ASST-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35340">
        <property type="entry name" value="PQQ ENZYME REPEAT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14269">
        <property type="entry name" value="Arylsulfotran_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004882117" evidence="1">
        <location>
            <begin position="19"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="292"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM34714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="501" mass="54934" checksum="E97D3ADAB0E94438" modified="2014-04-16" version="1">MALLKQTLLAALATTSLHQSNDHYRSRPDLAPPQLNITIPAANPNGSEYVFIAPYSVDGTLERPGPYIYRKDGDLVWAGTGYYAGFVANFHPTTYQGKPVLQAFQGSIDGAHGEGFGQHVLLDQSYQHVATSTAANHRVSSIHEFNVIRGETALIEVFYTTPVNLSAYGGNSSQVWLGNGIFQENDIATGKLVFEWNALEHVDPSESLVPLGSKYANNGLSSAEAWDYFHINSLDKNEEGDYLLSSRHTSTIYKINGTDGSIIWRLGGKYPSFSQIGNWTFGFQHHARWQPQPSQLGTEVISFFDNSGDGTITFNDVSRALVIQINHTDSTATVLRKATAPYDLQAQSQGNTQLLSDDRIFVNWGSEGAFTEFGADNEILYHALIETGAVSYRGFLGNWTATPKESPALVALKTASNLVELYVSWNGDTETAAWRFFYVNGQEKTRVGQVDRNSFETAFTWKSTFALSSSARFVAEAVDTNGETLGQTSLTATTANIKLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W6QKS8</accession>
    <name>W6QKS8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Cytochrome b245, heavy chain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PROQFM164_S03g001491</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ferric reductase (FRE) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QKS8"/>
    <dbReference type="STRING" id="1365484.W6QKS8"/>
    <dbReference type="OMA" id="WMDEVLR"/>
    <dbReference type="OrthoDB" id="4494341at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000293">
        <property type="term" value="F:ferric-chelate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051410">
        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361:SF12">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G14340)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="239"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="12">
        <location>
            <begin position="307"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="381"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="381"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="394"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDM34764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="615" mass="68074" checksum="DFA22A5DCDC05589" modified="2014-04-16" version="1">MAATHPHIAARGYGSNATYIYEYSRGLGGVDVPRDVIFTRIIYGSLCVVAFALFCGRVAQISHAYLRQITATSASKHQQTFWAQEQSTWWSNIKKYILYAPLGSKRHNRELQLSSAVNVGTLPSRLQTILVALYFASQVAYCFILDYSVNHKAALVAELRGRSGTLAVLNMIPLFLLAGRNNPLIPLLHISFDTYNLLHRWLGRIVVIESVAHTAAWAVNAVDEEDFTRMLARVRETPFFLWGLIGTVAMVFLCLHSPSPIRHAFYETFLHLHQLAAVFAFLGVYLHLQIDNLPQQSWAKAIAGIWIGDRLARLFRLIHLNISTTGTTKMVVQALPGEACRVTFHLPKVVNIDPGCHVFAYIPRISWWMSHPFSIAWAEPSTSSTSTFSPSPTQDKRYNDVEKQSDLPTKPSKPSTQVSLIVGAQKGMTRRLYNLANAAPSKTLTLAGFIEGPYGSNPANFSSYGTAVLFSAGAGITHHLLQTRALVTAAAQNTAATRKVYLIWSVRSTDHLTWVSNYMDQILRLPNRRDILVVKLFVSKPRRAADIVSPSATVLMHSGRCRPDVVLDEILPGRTGATIVSVCGPGAFADEVRSAARERIGKGAVVDFAEEAFTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W6QKT9</accession>
    <name>W6QKT9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Crotonase, core</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PROQFM164_S06g000420</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM164</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792020">
        <property type="protein sequence ID" value="CDM37458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QKT9"/>
    <dbReference type="STRING" id="1365484.W6QKT9"/>
    <dbReference type="OMA" id="FQAIMDF"/>
    <dbReference type="OrthoDB" id="448450at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004165">
        <property type="term" value="F:delta(3)-delta(2)-enoyl-CoA isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000048">
        <property type="entry name" value="3,2-trans-enoyl-CoA isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051053">
        <property type="entry name" value="ECH/Chromodomain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43684">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43684:SF1">
        <property type="entry name" value="ENOYL-COA DELTA ISOMERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDM37458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="276" mass="30522" checksum="40EF9A8CDEEECE61" modified="2014-04-16" version="1">MSNDSLITVAYQARVAIVTLNRPDKLNALNADLYYLLGERLREIDSRDDIFITVLTGKGRFFSAGADVTSIRPGPDDSNSNERRELVKGFVANNVDVTRTFYNHSKILVVALNGPAVGLSAALVAHADFIYAAPHTFILTPFSSLGLVAEGGASRAFVERLGIAKANEALLMSKRITCDELVSAGFVNKVIAPESGEKDDSDGFLKKVLEEVDDRLGTHLNQTSLLKIKELVRRPERELLDRQNGLEAFMGLERFMKGFPQEEFRRLASGEKRHKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W6QL52</accession>
    <name>W6QL52_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S05g000564</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
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    <dbReference type="OrthoDB" id="3868412at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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            <end position="97"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM36731.1"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">FM164</strain>
        </source>
    </reference>
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            <end position="173"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CDM36876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
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    </evidence>
    <sequence length="232" mass="25981" checksum="DD0888B81558F00E" modified="2014-04-16" version="1">MSELSVEGQESKAVPCYHDHPPQYDSYYGSQDLLTSIIENEHTVRKLAKRMDELNTKITEIANIREELEKKTFLETPASNLTTAEDFEELSGAFTEIAQIMTGLSNACKERAVHNTDLYKAIGNLTDNELERTYDSLKRDPDRQIRHELAQDHKDRSDRDSGHNLQCSSTTNPVERAGNCTYNSCSRFAEPLATMDNINEKLPSDTANISKVADDTTAKSPVTPADKEPTVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
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                <person name="Dupont J."/>
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            <dbReference type="PubMed" id="24407037"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">FM164</strain>
        </source>
    </reference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004879710" evidence="1">
        <location>
            <begin position="28"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM35214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="131" mass="15173" checksum="BD7C83F3D8D77B43" modified="2014-04-16" version="1">MSAILYSLEAATCVAIWVILLIMSGAAIEESQANTVQIYSEPPNHKIKNKSVQTQKKCLDDKERLLDESRAIFKRKTYLIERLQLREDRMAKGDIGAAGPYPNSTARHLYELQFKIRQIWRELADLRRYCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W6QM22</accession>
    <name>W6QM22_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Autophagy-related protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">atg2</name>
        <name evidence="14" type="ORF">PROQFM164_S07g000231</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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            <taxon>Penicillium</taxon>
        </lineage>
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    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
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                <person name="Dupont J."/>
                <person name="Gouzy J."/>
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                <person name="Abraham A.L."/>
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                <person name="Lacoste S."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FM164</strain>
        </source>
    </reference>
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            <dbReference type="ChEBI" id="CHEBI:57262"/>
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            <dbReference type="ChEBI" id="CHEBI:57643"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
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            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out)</text>
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            <dbReference type="ChEBI" id="CHEBI:64612"/>
        </reaction>
    </comment>
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            <topology evidence="1">Peripheral membrane protein</topology>
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            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ATG2 family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="GO" id="GO:0005789">
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
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            <end position="431"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
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            <end position="1682"/>
        </location>
    </feature>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00009714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDM37883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="2096" mass="229639" checksum="50FD792E0D61CFCB" modified="2014-04-16" version="1">MASYFMPSFFQKRLLKYALSRLGLVDTEALDPDNLGIRWGQRSIIELRDIGLKLEKLSTILNLPPSCELLSARVQLLRITLPADFHNSGILCEANGIDVHIRLLSEEPKKEQNTKNKGGKDDYSAVPTPSGLAESFLESEPKEEREELQAAIASQSQVLPHDPLAWSVDDDDELGLGSDTLSLPSFVAGFLKGVVDRLQLKIKDAVVRVDMELKQDGTSKRQPEHKPDLVAGLLSVGEIDVHGVSEKTVGPDEALPFRQGKRLISIADINVGLISDPSVFSNYSRFAAPASPSTTMRSKGSEPSSRASSPSPLYRSVEEPLAMTQSTIFEPPQAFGHSSTTSDDLEASAFSHGRFSDADSESGSHHGGYLEDSHVFGDDPFQDNPGYLDSVIDTQFDDFDDEQSPVIHPEEDQRFRNQWGSHMSHGPQSLHHSQRAEYSDEPLLPSDSHHMSRTYETHNGQIGSEIDETTPLTQHYNDYNENEHNERSQLSVSSHSSSTSPRPEPESTGPREETPNVDLNESRLFSHDEAQSLYMSAISQDVGDSFMPHIPGGWGSFNRGSKSRSALDDRSKITAPIDPAQSIQVQDEANSRCASPSGDNVTEGHDLDDQGQSQTLHKDRPSTSSSPGLHRINEMRKSILTVDKILMWFSPPASEEEAPALSSPVPRKENAESDLTESTVSFGDSAPEESLLASRLYKSTRFGRDFVEARAQSSAGPELPEIAVEVFSISVHFDIATGWLLTKIGQKLSHAVDTAEKDMSAKQSRKDQPARTPPVHLAVHAFSIKFIEHVPGHVYSSDDNGSSSSPPYNMDDVILRLSLSGLDARLSAQSVTTKLKLHVSKFAFGFASEDIIFFDERLKMRESTRDVLSPSQGDISISLVKSSDLTKVDISTLPLHINLNVQRLEEVLGWMGGLSTILELGSSMSSVSTVKGCPPPTKARPRGVHFETSVPAIDTTKGKSAPLKINARVGAILLDVTGETHCLQLTTTAVKIVSRFEGIGIQIDKAKVIGPLSIDDASSDTPAKITLNNIRLEFLFAPKEVDLDRLLTLITPSQDKFEVEDDIMLDTLLRQRRQGSVLRVTVGRLETFISDTSGLEPLSSLAVELSRLSNVTKYLPEDDRPGILTLMLVRDFQGHVHVGGEVGDLKSQLTDVEVAHITMPSLTAVQIGTMTVSRNNDEELVGQALWPPNRCEDPDQSYPPVLMARFIPDEMDPTYKIKLHNLLVEYTVPSVTAFLGLGGNKMSGDLASSMVNSIANLAEHSIPSSSMTGRPMSTESSSSTKPVKLAVVFRDCVIGLNPRNSHAKGLAVLTNAKFGGSLHGDESAEASLDIRKASLMIIDNVYHEEAYNLHQRGSVVSQDTQAQAYIDKGYVPVSSISSATASVKLTSAEDGTKSLDVELRDDLLILETCADSTQTLISIMNGLQPPTPPNVNMKYRTEVMPIQDMFASFTGDAFAANPPISNDNDLATIPEGSSGEDQLTDELEYVSDFYPVKGGPGGVGVEGMEAGSNDLLDSFHSQYQVSSSMTELDFQEDHFAKKSAVGGTAHRWDSTQNTYGFTNDTKLERSPLRVRVRDVHFIWNLFDGYDWQRTRDTISKAVKDVEIKATERRSRGSQVSPLAEDEEESVIGDFLFNSIYIGIPANKDPRELHREINHDIDDFTSETGSYATTATLTGAGSRQGRSGSKREKKLRLHRSKHHKMTFELKGVSADLIIFPPGSEETQSSLDVRVKDLEIYDHVPTSTWKKFATYMREAGEKESGTSMVHLEILTVKPVPELAASEIVLKVTVLPLRLHVDQDALDFMSRFFEFRDEAAEPSDTPGDVPFLQRVEINAVQVKLDFKPKRVDYAGLRSGRTTEFMNFFVLDGADMVLRHVIIYGVSGFDRMGQTLNDIWMPDVKQNQLPGVLAGLAPIRSLVNVGGGVRDLVVIPMREYRKDGRIVRSIQKGALAFAKTTSNELVKLGAKLAIGTQTVLQGAEDLLTPNAPTFDDDSADEDEAKKISLYADQPVGVVQGLRGAFSGLERDLLLARDAIVAVPGEVVESGSAKAAAKAVWKRAPTVILRPAIGVSKAVGQTLLGAGNTLDPSNRRKMEDKYKRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W6QM57</accession>
    <name>W6QM57_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S04</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S04g000140</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QM57"/>
    <dbReference type="OMA" id="GFIVEDW"/>
    <dbReference type="OrthoDB" id="425354at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053037">
        <property type="entry name" value="Pericyclase_pydY-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38115">
        <property type="entry name" value="LIPOCALIN-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38115:SF1">
        <property type="entry name" value="LIPOCALIN-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM35259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="223" mass="25393" checksum="823A8CC6451FE79F" modified="2014-04-16" version="1">MAAPREITIECLNGRWVLNKDLTSEADPILKLQKVPWLLRKAFEFATIYIQISQYQTPASETSQPSTSIDFTQTATAGLAATKEERVLDWKVLDHEDYFFGEVKAQSEFVHGVIDAGGIIRPEFELQTAMSNDQIKQYLRGEIQEDGSKSTGFLVEDWSGMSEEGPGLWVHTFERNVKSGWTAEQIWGFEMFGDSRYFSRRGVIMTTRGEYMCGRIVFDFVST</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W6QMW7</accession>
    <name>W6QMW7_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">PROQFM164_S02g001117</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QMW7"/>
    <dbReference type="STRING" id="1365484.W6QMW7"/>
    <dbReference type="OMA" id="DPPYADI"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06609">
        <property type="entry name" value="STKc_MST3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000411">
        <property type="entry name" value="Probable Ste20-like kinase Don3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000488">
        <property type="entry name" value="Related to severin kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050629">
        <property type="entry name" value="STE20/SPS1-PAK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012:SF10">
        <property type="entry name" value="FI20177P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012">
        <property type="entry name" value="STERILE20-LIKE KINASE, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 19" id="KW-0418">Kinase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="18">
        <location>
            <begin position="11"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="285"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="539"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="288"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="301"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="329"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="354"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="441"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CDM30967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="622" mass="68891" checksum="4FF784E84A65AC65" modified="2014-04-16" version="1">MPPPIDPETIYTKQACIGGGSFGKVFKGLDRRTGESVAIKIIDVENAEDDVDDIIKEIAILSELKSPYVTKYHGSYLKGSNLWIIMEFCAGGSCHGLLRPGVIHEEYIAIILRELLRGLDYLHSDQKLHRDIKAANVLLSASGQVKLADFGVSGQLSATMTKKNTFVGTPFWMAPEVIKQSGYDYKADIWSLGITAIELACGDPPYADIHPMKVLFLIPKNPPPTLVGDFSKPFKQFVELCLRRDPKERPSAKELLEHPFVKRAKRTTYLTELIERAERWQITHRGQDDEDEYDEYDDREADQTAKARTQEKEDLWDFGTVRPVGKTSAPPSRSGTNTRTETEEWDLCEETPRQAGTSQPQSHAQVSPANPAFNVSPTKTPLPPSAPSSPLKQRSSQTALPPRKVVSPVASKPAVDNLPTRGLNEQYAQAATHSAGKLDTASSAKPSSAPQSPRIPQVALPRHTEPLQHAKPVSGLKSKRAPANMDDRAMPHRSTPPTPTSSDHKRSTRPPPETERPTACGTVILPALRAAMDRRRNNLVRLEPGRNPNEPPATPEEEKDFDRSVRIHHGLEKVAEDIARAFNSLQHWDMERPVDMGGGVDTVLDVFLEEVLARMQARTDVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W6QNA1</accession>
    <name>W6QNA1_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">U4/U6.U5 small nuclear ribonucleoprotein 27kDa protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PROQFM164_S06g000398</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May play a role in mRNA splicing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of a tri-snRNP complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SNUT3 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792020">
        <property type="protein sequence ID" value="CDM37436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QNA1"/>
    <dbReference type="STRING" id="1365484.W6QNA1"/>
    <dbReference type="OMA" id="VDSSTMW"/>
    <dbReference type="OrthoDB" id="21368at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013957">
        <property type="entry name" value="SNRNP27"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31077">
        <property type="entry name" value="U4/U6.U5 SMALL NUCLEAR RIBONUCLEOPROTEIN 27 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31077:SF1">
        <property type="entry name" value="U4_U6.U5 SMALL NUCLEAR RIBONUCLEOPROTEIN 27 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08648">
        <property type="entry name" value="SNRNP27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="U4/U6.U5 small nuclear ribonucleoprotein 27kDa protein" evidence="9">
        <location>
            <begin position="176"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="20"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="88"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="129"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="163"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDM37436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="231" mass="27272" checksum="A35ABAA6F68F0D79" modified="2014-04-16" version="1">MAEPPAKRARRVDSSTMWDSNDKRPHAPEQESDRDRKRSPAPRDDRRDGRYRSRSQERKDGRRDRSWSRDRRDRDRDGRGAQNRKRSTSRERNQDRRGNAPKNVKFRERSRSRSPHRNGTKARSPPRGPKSDRHGDRKDPRSRDVGQKANGAQPGPDRHEDAMDVDFNEDADEDEMEAQMRKTMGFSRFRTTKNTKIPGNDIYGVRKEKKIEYRQYMNRQGGFNRPLSPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W6QNI5</accession>
    <name>W6QNI5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Probable transposable element</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S13g000001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792027">
        <property type="protein sequence ID" value="CDM38478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QNI5"/>
    <dbReference type="STRING" id="1365484.W6QNI5"/>
    <dbReference type="OMA" id="IVETDQC"/>
    <dbReference type="OrthoDB" id="3261222at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM38478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="94" mass="10900" checksum="276762B8A03BF834" modified="2014-04-16" version="1">MARLNGYLNQINIVETDQCDCGQARETVEYFLFRCRKWMTYRTEMLQCTQTHRGNISFFLGGKQPSDDQKWTLNLEAVQASIRFAIATGRLEAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W6QNL2</accession>
    <name>W6QNL2_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Genomic scaffold, ProqFM164S04</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S04g000580</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QNL2"/>
    <dbReference type="STRING" id="1365484.W6QNL2"/>
    <dbReference type="OMA" id="ISGWKTM"/>
    <dbReference type="OrthoDB" id="2251794at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004882200" evidence="2">
        <location>
            <begin position="21"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM35699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="253" mass="27168" checksum="53A738CFE4456F3F" modified="2014-04-16" version="1">MVFTPILALAFVALTPIVNAYPVTGSVIDCHSGPGASHSVVKTYEERADIEIVCQATGTTVDGSDIWHQTVDDCYVSDFSSDVTEECPSEDTVDDEDTLSEGALSERSTSSNLPGLSATQTKHAKAIIAEAKKEGLGRQGCLAGISTALVESNILIYANKKVPASLKYHHDAVAEDYDSVGIFQQRAVYYPNIAADMDAAKSAAQFFKIMKKVSGWKKMNTGKLCQKVQGSAYPSRYQERVPESKKICSAGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W6QP61</accession>
    <name>W6QP61_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="5">tRNA-splicing endonuclease, subunit Sen54, N-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PROQFM164_S02g001527</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SEN54 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QP61"/>
    <dbReference type="STRING" id="1365484.W6QP61"/>
    <dbReference type="OMA" id="MYMRLRH"/>
    <dbReference type="OrthoDB" id="408683at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000214">
        <property type="term" value="C:tRNA-intron endonuclease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000379">
        <property type="term" value="P:tRNA-type intron splice site recognition and cleavage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024337">
        <property type="entry name" value="tRNA_splic_suSen54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024336">
        <property type="entry name" value="tRNA_splic_suSen54_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21027">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21027:SF1">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12928">
        <property type="entry name" value="tRNA_int_end_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA-splicing endonuclease subunit Sen54 N-terminal" evidence="4">
        <location>
            <begin position="74"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="103"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="426"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="435"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDM31377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="448" mass="49510" checksum="3EDB3F9DAA5A0808" modified="2014-04-16" version="1">MADADEDAVRAPATASTEPDIDLSDETQDFRFLNHLNFFADSSPSIPRRGEKDFEPNPTELQADVLSASRGAMHNALSYPRLHGAKTRIIAFYAPDGYVPPVQIDRATPKASGEDGKSSESTPKPARPLPNSARISPDACVYVPNPKGQFFKTMGQADSTSRIWLLPEEALYLIERGSLDIRWPSPSGSTEDLSVPMSLQAAYACFMGRGGLTLERYSVYTGLKRLGYALVRAPGWCDDIQQQDADALGSSEITPPKIHGPGLAGMLASLFNWIHDPHSTASTATGPIIGTGIHRSYMDVYRKLAIIPWYDPVTAPERHPFDTTPPFRVVFHIYKPSTPIKKSALPTPDFRIAVVSTRDQTTMPTMTQLGALLESTPLDPPRGEKMDRMMYMRLRHGYRNVVMAVVDQGVVSYLRIADSAFGKEKLYENKGGPQGHKRNYANQKSRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W6QPH2</accession>
    <name>W6QPH2_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PROQFM164_S02g001637</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type III membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the OST4 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QPH2"/>
    <dbReference type="OrthoDB" id="2124077at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018279">
        <property type="term" value="P:protein N-linked glycosylation via asparagine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018943">
        <property type="entry name" value="Oligosaccaryltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051307">
        <property type="entry name" value="OST4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036330">
        <property type="entry name" value="Ost4p_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48164">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48164:SF1">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10215">
        <property type="entry name" value="Ost4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103464">
        <property type="entry name" value="Oligosaccharyltransferase subunit ost4p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="36"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDM31487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="67" mass="7342" checksum="B9409E4EA441567D" modified="2014-04-16" version="1">MISDNDLYRLAIFLGSCAMMMIVLYHFLDVNSSEEEPESAESASQIKAKDTVPVVSTDRVSASEKGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W6QPP1</accession>
    <name>W6QPP1_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cobalamin (Vitamin B12) biosynthesis CobW</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S02g001697</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QPP1"/>
    <dbReference type="STRING" id="1365484.W6QPP1"/>
    <dbReference type="OMA" id="WSQAGPN"/>
    <dbReference type="OrthoDB" id="272672at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03112">
        <property type="entry name" value="CobW-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011629">
        <property type="entry name" value="CobW-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003495">
        <property type="entry name" value="CobW/HypB/UreG_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051927">
        <property type="entry name" value="Zn_Chap_cDPG_Synth"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43603">
        <property type="entry name" value="COBW DOMAIN-CONTAINING PROTEIN DDB_G0274527"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43603:SF1">
        <property type="entry name" value="ZINC-REGULATED GTPASE METALLOPROTEIN ACTIVATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02492">
        <property type="entry name" value="cobW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07683">
        <property type="entry name" value="CobW_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00833">
        <property type="entry name" value="CobW_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90002">
        <property type="entry name" value="Hypothetical protein YjiA, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CobW C-terminal" evidence="2">
        <location>
            <begin position="317"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="347"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="532"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="348"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="534"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="562"/>
            <end position="577"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM31547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="577" mass="65453" checksum="7B4E3D7DF222F9B3" modified="2014-04-16" version="1">MVINSGTDSVSYNVPAPLEEKPKTRQMPVTLLSGFLGSGKTTLLKHILKSPDHGLRIAVIVNDMSQLNIDATLIQNHKVSQTTEKLIRLQNGCICCTLRGDLLAELAALTKRNEVDYVIIESTGISEPMQVAETFTSEFSSAMLEAEDQIANDDEEARKILDEIVNLGGLHTMARLDTTVTVIDAFNLLSSFDTAEFLSDRYGREEIVPEDERTISDLMVDQIEFADVLILNKVETVDQATRDKLMHLLKLLNPVAKILESNYSQIDVREIINTNKFDFVRAASGPGWLQSLHEMTIQTTGNGERLAPKPETLEYGINNFVYTARRPFHSRRLFALLHDKFIILQNNEVEEEEGDEEDGEEDEEEEEEDAMDTDSDSGSVEDFDQPDPAVIMSNKRNHPAFGPVLRSKGFFWLTTRPWQFGEWSQAGGMLTLGCGGPWFAELPDEAWPEDKDVRESIQNDFQGAWGDRRQEIVFIGEGIDTGKITALLDECLLDDKDMKKWEKVMKNKKMSRDEKTDKLAKMWEDGWEEWPAFEVEEEEEEEEEQEPEQGKHRISEYLGQKKGTKHAHGHNHRMVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W6QPR1</accession>
    <name>W6QPR1_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nucleoside phosphorylase domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S12g000004</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792026">
        <property type="protein sequence ID" value="CDM38395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QPR1"/>
    <dbReference type="STRING" id="1365484.W6QPR1"/>
    <dbReference type="OMA" id="YTRCDEN"/>
    <dbReference type="OrthoDB" id="1577640at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF11">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleoside phosphorylase" evidence="2">
        <location>
            <begin position="66"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="337"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="496"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="496"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM38395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="651" mass="73277" checksum="69A1913B1AA4A694" modified="2014-04-16" version="1">MAESSKSQPEQSVLGQNKAGTDTPPCRKRLQHSAYTIGWVCALVKEQTAARAMLDEEHEPLPIPSNDLNTYTLGSIRGHNIVIACLPNMEANSAATVATSMINTFLTIRFGLMVGIGSGIPSKVNLGDVVVSQPVADYSGVVQYDMGRLGRGGQFVHTGLLNRPPNALLKALNRLKSDHEIYGSQINEYLDDVERKYPKLAPKYTRCDENGKSSENEKEKRTEREVRVHYGLIASGNKVVKDAQSRDSLDKAFGGHLLCVEMEAAGLMNDFPCVVIRGICDYADLGKEKGWQEYAATVAAAYAKELLGCLHPSLVDAEDPGKATLENVRQQIERVQQTVMDSGDSDSSSDNDSLFSAPVSVPSTRSFDSGKGEMNSLLIEQFAHLLNEDGDMLSLLLIGLSREPIGFERMRNNFRRLLKHFANDLKADILSESHRDLVRFVSSYSVMITRELFAMVSVDEQRKLNPYERLAHERKVESYLQSLQDAALQTSEVIEGLDPDDEDSDEGSVAEGANEDEPYDGSLQNLDQMKHFIRESAAYQILRRRLEEFVQPSLSSQFRNLVIKWSKPENKNHGDVARYKLRNLVTDLQHVNPSEIRFEHDESSSRFSMFISQYQHLIERWTGESWDWWPLPRYPRPLAESETRLRWKCII</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>W6QQA4</accession>
    <name>W6QQA4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Zn(2)-C6 fungal-type DNA-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PROQFM164_S09g000082</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792023">
        <property type="protein sequence ID" value="CDM38166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QQA4"/>
    <dbReference type="STRING" id="1365484.W6QQA4"/>
    <dbReference type="OMA" id="IYMHEIG"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001216">
        <property type="term" value="F:DNA-binding transcription activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.240.10:FF:000003">
        <property type="entry name" value="C6 transcription factor (Leu3)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF39">
        <property type="entry name" value="TRANSCRIPTION FACTOR PBCR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="10">
        <location>
            <begin position="89"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="184"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="677"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="725"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="131"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="45"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="76"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="677"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="694"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="729"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="770"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="800"/>
            <end position="820"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDM38166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="877" mass="97576" checksum="FF82B182024B4AD4" modified="2014-04-16" version="1">MEIDPQLQHADPQRSFYTPIRPTMSTGPEYPEPPSHAPLNPYPSRDTHGDGRGHEHGPRDTHPSFGMGLDSNQSPDPHDPPGDAKRSRACEPCRQLKVRCDPDPAHPEGSCKRCAKARRTCVVTAPTRKRQKKTDSRVAELERKIDALTATLQASNSTSALFSGGAGQRDEQLAGRRWIAGSKRQHTGELKDPSGGLLAPRYSRPGSPSAEQIPSHASKHWRRPVGVDSAPPPPKHEAGNEFADMIDRGIIDYKTASAAFDRYIHQMAPELPFVVFPPGTTMGEVRRNKPYLFLAIIAAAVAVFNSDAQPILVNETYRLIAEQVVVKGQKSLELVQTIMVCSIWYLPPDNFDEIKFYSLIHMAVVMAMELGLNRRISDNRRSFSVIRELIIKKPTGPAFDPKGPEARRTWVGCYFLSVQMSAALRRVHLVTWQPYMDECLQILETHPDALPSDRNLKWWIKLGSIMEDAGNLFSEEDPGCITTFADSKVWYNIKMFEDRLAQWREEVPRDVYTEPMVHAEHVLNLFVHGSAMCVDYNTVNNSPSQDDLHNSSIAIDALSTAIRCIHESLDVICTINIDRLISLPTTSLARTSYPVVSLIKIYSLFMSPDSRIGQILDVQSLKLDYYLDKVIAHYRAAAARDGGRAAARFGNIMVLLRNWFIKKRDQGDHGRELKEVFSNDQKSSDHRQARHNPDTPNAVSTNPRARIAPGMTPLHFLSEVAMGDPAHRANNSNSQRSIAGQSYSSNHSPSSTVNPMPTPSSSNFVPDPPQTSWSSSSSYPTTLPSSDSNHIETRGYYQPYPSTEITQNYPDLPSSTQTQGYPDMSTVAGVQLAPPMGMAPEVGMDPNFGDPWFTLGNMMDEGLFTFPLSFDGNFGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W6QQH1</accession>
    <name>W6QQH1_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S10g000050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792024">
        <property type="protein sequence ID" value="CDM38236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QQH1"/>
    <dbReference type="STRING" id="1365484.W6QQH1"/>
    <dbReference type="OMA" id="CQMNDGM"/>
    <dbReference type="OrthoDB" id="190201at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM38236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="314" mass="34674" checksum="778420EA55964AAC" modified="2014-04-16" version="1">MDYAIFPIPASIRRRLPRLYSARAVPETTESSGDQHRGLASSSEPHLLCQSQLSASVVPELQGPSMASNDLDLFDPGPVGSDSPREDMGSPTKYETTSGLRWNRVVPAFNLLRNAGYEAQQPQADGRLARSLYFNALIYLLDALPSDLTNEETSMLQHHIPEPVKVELTTYSQPSGYMEGANHTICPPPRSYLHKFLASMILQLFILLRFLLPYAKVLLRQIYEYDRTHRITRRIMTITLEAADGLGKGGVNIGAAVSKFNEGRIGAALTNFAVWWMEGVAGGIYEGVGEGMIHLGLLGKEADLDRLPLEPMSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W6QQV1</accession>
    <name>W6QQV1_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">D-lactate dehydratase</fullName>
            <ecNumber evidence="1">4.2.1.130</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PROQFM164_S02g002078</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>methylglyoxal + H2O = (R)-lactate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27754"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16004"/>
            <dbReference type="ChEBI" id="CHEBI:17158"/>
            <dbReference type="EC" id="4.2.1.130"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase C56 family. HSP31-like subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.130" evidence="1"/>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QQV1"/>
    <dbReference type="STRING" id="1365484.W6QQV1"/>
    <dbReference type="OMA" id="DPHSLQM"/>
    <dbReference type="OrthoDB" id="543156at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019172">
        <property type="term" value="F:glyoxalase III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019243">
        <property type="term" value="P:methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03141">
        <property type="entry name" value="GATase1_Hsp31_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050325">
        <property type="entry name" value="Prot/Nucl_acid_deglycase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48094:SF11">
        <property type="entry name" value="GLUTATHIONE-INDEPENDENT GLYOXALASE HSP31-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48094">
        <property type="entry name" value="PROTEIN/NUCLEIC ACID DEGLYCASE DJ-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="DJ-1/PfpI" evidence="6">
        <location>
            <begin position="28"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM31927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="235" mass="24440" checksum="CDC5FC9ED1301A49" modified="2014-04-16" version="1">MTPKVLVVLTSEDKLGTTGKPNGWFLSEFAHPYEVLRDKVSLTVASPKGGEAPLSPASIKMCESDPISQKFLKEQKALWTNTEKLADVLPRAGEFDAIFYVGGHGPMFDLTENPTSLALIQAFAAANKPVAAVCHGPCVLLNATAPSGVPLISGVGVTGFSNNEEDAVGLSSAMPFMLETELGRVTGGKYVKAAKPWEEMIVIGKAAGTGSTIITGQNPASATGVGKAILKALGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W6QQY8</accession>
    <name>W6QQY8_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transposable element</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S05g000322</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QQY8"/>
    <dbReference type="OrthoDB" id="4371331at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004882285" description="Transposable element" evidence="1">
        <location>
            <begin position="17"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM36489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="132" mass="14415" checksum="563D1C67E027A860" modified="2014-04-16" version="1">MPRGPFAGFYWPKVWAGHLAVSGRLIPALVGSMVEEQVPEECQKSARKVPRATYESRFTEGFFFRGKDNTKAPGMHFALPGTGLIGYKRPGVAAAKAQTHLISKHPTASQSLWSVTAFELAAWESTLLVISP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W6QR09</accession>
    <name>W6QR09_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S02g002133</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QR09"/>
    <dbReference type="OMA" id="EINCTPH"/>
    <dbReference type="OrthoDB" id="4360026at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM31982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="589" mass="67160" checksum="9DB57B304E05ED43" modified="2014-04-16" version="1">MAATQVAGQSSVISSTDLPVHAGKQQPAEYDLDQCIAAIKGEKVPSDVTSFWHRRAVIRGIRDSLQFATSPTIIELCSGDDAHQFSRARNARLIMSNVIPDMQPATEPYCIWYPEFASEETYRELASRYPSMRYQVGRACAAALYTDLYKELDLLPDVSIAEEACNAAEDAEIFKIIMSAPQRWAVMDDFTRSVNLTSPQAPAFLNGNMKPRRALSQRVLPPENLPDTTADDIDIEEDGFIGFEEEIEIDRDAILGPGDSEDLWMPLSPDLPVLDKRLPTQMAAWEGNVDRYARFMHPRRLRTEIEYNCILRGIYHHTSFARWWAYQLETNPGRIILPGKLLSEGNERERREIRTAINARRIMNNDISDLDDDSDCLPWLIWWPVRPHENTLRELAGKCPSMRPQIAITSILCDYQSLFMALNPPPRESYFEAAKQSRNPYYLQYLEEFVRERSIGSGKISEFDPYDTTKKTSLGPDLEPRDFLTHSSVKFSDMAVPWGQHPRGEWDSPGIYGGLPVDPGIVERYMWLSTETAQKIQDEYRAYSGVYGDSADTGYLYIDDDDPDNELWLKLSRPLRPMTSFEMKTSDVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W6QR41</accession>
    <name>W6QR41_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S12g000045</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792026">
        <property type="protein sequence ID" value="CDM38436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QR41"/>
    <dbReference type="OMA" id="SAMGWPE"/>
    <dbReference type="OrthoDB" id="4265129at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM38436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="184" mass="21190" checksum="67ADAADB6C245CEA" modified="2014-04-16" version="1">MSPRSAMGWPEWEEKNLLPWLDAHRALSWKARSHAYYEQYRVVRTVESLRGKKYHILRKRRRTSAGSPEHRGNRKRSGAIHRSVGDMASLESLPDTNTAQGSVDKWLQTVPTVEPSHTRGSESTQTKSSRPGRMTLVPVYYRPPGTRSSSCNWDYVHRVCAARKLRYQWTKCEQHSSGIQVTVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W6QR61</accession>
    <name>W6QR61_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Probable transposable element</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S12g000065</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792026">
        <property type="protein sequence ID" value="CDM38456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QR61"/>
    <dbReference type="STRING" id="1365484.W6QR61"/>
    <dbReference type="OMA" id="KCTENCR"/>
    <dbReference type="OrthoDB" id="4207519at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF62">
        <property type="entry name" value="HTH CENPB-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE-1" evidence="2">
        <location>
            <begin position="2"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM38456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="150" mass="16811" checksum="B28B2468608759B5" modified="2014-04-16" version="1">MVGRYRLLVLDGHGSQLTPQFDQICEENNIIPICMPPHSSHLLQPLDIGCFAVSKRTYGRLVETKMRNGINHINKLDFLEAYPTVRIEAFKSETIKNSFSAAGLVPFSPDRVLLKLDVYLRTPTTPPSRGSNSSQNFTPKTPATGKDLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W6QS27</accession>
    <name>W6QS27_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">anthranilate synthase</fullName>
            <ecNumber evidence="3">4.1.3.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">TRP2</name>
        <name evidence="10" type="ORF">PROQFM164_S05g000747</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM164</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 1/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the anthranilate synthase component I family.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.27" evidence="3"/>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QS27"/>
    <dbReference type="STRING" id="1365484.W6QS27"/>
    <dbReference type="OMA" id="GCVGYLD"/>
    <dbReference type="OrthoDB" id="1865897at2759"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004049">
        <property type="term" value="F:anthranilate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:L-tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.120.10:FF:000003">
        <property type="entry name" value="Anthranilate synthase component 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.120.10">
        <property type="entry name" value="Anthranilate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005801">
        <property type="entry name" value="ADC_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019999">
        <property type="entry name" value="Anth_synth_I-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006805">
        <property type="entry name" value="Anth_synth_I_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005256">
        <property type="entry name" value="Anth_synth_I_PabB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015890">
        <property type="entry name" value="Chorismate_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00564">
        <property type="entry name" value="trpE_most"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11236">
        <property type="entry name" value="AMINOBENZOATE/ANTHRANILATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11236:SF9">
        <property type="entry name" value="ANTHRANILATE SYNTHASE COMPONENT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04715">
        <property type="entry name" value="Anth_synt_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00425">
        <property type="entry name" value="Chorismate_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00095">
        <property type="entry name" value="ANTSNTHASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56322">
        <property type="entry name" value="ADC synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="Anthranilate synthase component I N-terminal" evidence="9">
        <location>
            <begin position="40"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="Chorismate-utilising enzyme C-terminal" evidence="8">
        <location>
            <begin position="229"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDM36914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="513" mass="56276" checksum="44B233BCF7F29888" modified="2014-04-16" version="1">MATAIATIPSLETAREVISKSRNSEYPPNLLPVTASIAADLLTPTLAYLKIAENSRLSFLFESAATTETIGRYSFVGADPRKVIKTGEGHGPAADPLPYLEDELSQFRVATVPGLVLPPLTAGAIGYVGYDCVRYFEPKTARPLKDVLGVPESFFMLYDTIIAFDHFFQVVKVITYVPIPSADADIEAAYLKGQSIIQKTIEKLLQDRTPLPPQGPIIPNQEYTSNIGQEGYEGHVNRLKQHIAKGDIFQTVPSQRLSRPTSLHPFNLFRHLRTVNPSPYLFYIDCQDFQLVGASPELLVKEERGRIISHPIAGTVKRGKTPEEDAALSEELRSSLKDRAEHVMLVDLARNDVNRVCDPTTTQVDRLMVVEKFSHVQHLVSQVSGVLRPGMTRFDAFRSIFPAGTVSGAPKVRAMQLIAELEGEKRGVYAGAVGYFGYNSANEDGSAEMPGAMDTCIALRTMMVKNGVAYLQAGGGIVFDSDPYDEYIETINKLGANIACIKGAEAKYLSMEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W6QSM3</accession>
    <name>W6QSM3_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">60S ribosomal protein L3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">rpl3</name>
        <name evidence="8" type="ORF">PROQFM164_S06g000064</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the universal ribosomal protein uL3 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792020">
        <property type="protein sequence ID" value="CDM37104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QSM3"/>
    <dbReference type="STRING" id="1365484.W6QSM3"/>
    <dbReference type="OMA" id="QRTEYNK"/>
    <dbReference type="OrthoDB" id="1611972at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000079">
        <property type="entry name" value="60S ribosomal protein L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1430.10:FF:000001">
        <property type="entry name" value="60S ribosomal protein L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.960.10:FF:000001">
        <property type="entry name" value="60S ribosomal protein L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.960.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000351">
        <property type="entry name" value="Ribosomal protein L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.960.10">
        <property type="entry name" value="Ribosomal protein L3, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045077">
        <property type="entry name" value="L3_arc_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044892">
        <property type="entry name" value="Ribosomal_L3_dom_3_arc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000597">
        <property type="entry name" value="Ribosomal_uL3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019926">
        <property type="entry name" value="Ribosomal_uL3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11363">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11363:SF5">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00297">
        <property type="entry name" value="Ribosomal_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00474">
        <property type="entry name" value="RIBOSOMAL_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6 8" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="17"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM37104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="429" mass="48398" checksum="8CACE432EFD21375" modified="2014-04-16" version="1">MSPFFPSVSPHTKRAKSTSTFPDRPPTTSTTNDNRVKMSHRKFEAPRHGSLAYLPRKRAARHRGKVKSFPKDDAKKPVHLTASMGYKAGMTTVVRDLDRPGAKMHKKEIVEAVTVIETPPLVAVGVVGYIETPRGLRSLTTVWAEHLSDEVKRRFYKNWYKSKKKAFTKYAKSHAESSGASITRELERIQKYCTVVRVLAHTQIRQTPIKQKKAHLMEIQVNGGSVADKVEFARNLFEKTIDIDSVFEKDEVIDVIAVTKGHGFSGVTSRWGTTKLPRKTHKGLRKVACIGAWHPNHVQWTVARAGQDGYHHRTSCNHKIFRIGKGTDEANASTEFDISKKQITPMGGFVHYGEVKNDFVMVKGSVPGVKKRVMTLRKTLYPQTSRRATEKVELKWIDTSSKFGHGAFQTFEEKKAFMGTLKKDLVETV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W6QSX8</accession>
    <name>W6QSX8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="7">CDC45 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PROQFM164_S02g002763</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CDC45 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QSX8"/>
    <dbReference type="STRING" id="1365484.W6QSX8"/>
    <dbReference type="OMA" id="MQSEEWI"/>
    <dbReference type="OrthoDB" id="10258882at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902977">
        <property type="term" value="P:mitotic DNA replication preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003874">
        <property type="entry name" value="CDC45"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10507">
        <property type="entry name" value="CDC45-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10507:SF0">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 45 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02724">
        <property type="entry name" value="CDC45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="109"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM32612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="203" mass="22587" checksum="8170313FF4C452D5" modified="2014-04-16" version="1">MTSVYSARSHKAPVLGVFRIAVVKDGPDVKLFRNPGALTKLALWIAEAIRVQEKERGDSVKLGQKGAAGTPLVLAGLDEDRHLYVVVGTGGGGGVVDFAAIAKRQEERKKKKDVKEKKQKERSERRSQRAAERAEREEEIVRGRGRSAWKHLLRNRFGIAFQEVVQETNARVRIDSFEHCVVKVQKDDLGGFLEALSFRSVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W6QTI0</accession>
    <name>W6QTI0_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S02g002993</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QTI0"/>
    <dbReference type="STRING" id="1365484.W6QTI0"/>
    <dbReference type="OMA" id="WISFCER"/>
    <dbReference type="OrthoDB" id="3544487at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021842">
        <property type="entry name" value="DUF3435"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37535:SF2">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G09300)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37535">
        <property type="entry name" value="FLUG DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11917">
        <property type="entry name" value="DUF3435"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="30"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM32842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="349" mass="40184" checksum="33C5DA56A2105398" modified="2014-04-16" version="1">MASRGSIPSGDESDISPCHSENFSDHASDTDSSTAPSVFDLSSESESESEVESEDDLASEDEEEQLPPEYYLHEAESLDRLDEAQYFWDKFCKGTKRDPAECLYWLSDNEETVRFLKALFLWRCDQRRGKDRRRRTAGVKTKSTLDAFWKWWHLIYKAEVGYELSKDVYVKIRDVLAIVATEKGLSLKGRPKATIYVEDVAEFARVILSTTEMTFPYSCRPGALLKLRFQDLKLTLVRDPNGGRPQLFIYLRPEFTKTFLGEKESNTFPIPEIIFDPTLVLSPYVFLLGILFRIGAFKSLSKDGPVMDCPEKLYRLRVLYRLGEQELKLKDKILSQNVFYQVLREPSGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W6QU67</accession>
    <name>W6QU67_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Poly [ADP-ribose] polymerase</fullName>
            <shortName evidence="15">PARP</shortName>
            <ecNumber evidence="15">2.4.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">PROQFM164_S02g003223</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>NAD(+) + (ADP-D-ribosyl)n-acceptor = nicotinamide + (ADP-D-ribosyl)n+1-acceptor + H(+).</text>
            <dbReference type="EC" id="2.4.2.30"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the ARTD/PARP family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.-" evidence="15"/>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM33072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QU67"/>
    <dbReference type="STRING" id="1365484.W6QU67"/>
    <dbReference type="OMA" id="QGENDRF"/>
    <dbReference type="OrthoDB" id="2017365at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003950">
        <property type="term" value="F:NAD+ poly-ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990404">
        <property type="term" value="F:NAD+-protein mono-ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070212">
        <property type="term" value="P:protein poly-ADP-ribosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00027">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01437">
        <property type="entry name" value="parp_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07997">
        <property type="entry name" value="WGR_PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.142.10:FF:000002">
        <property type="entry name" value="Poly [ADP-ribose] polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.140.10:FF:000001">
        <property type="entry name" value="Poly [ADP-ribose] polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.142.10">
        <property type="entry name" value="Poly(ADP-ribose) polymerase, regulatory domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.140.10">
        <property type="entry name" value="WGR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050800">
        <property type="entry name" value="ARTD/PARP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012317">
        <property type="entry name" value="Poly(ADP-ribose)pol_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004102">
        <property type="entry name" value="Poly(ADP-ribose)pol_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036616">
        <property type="entry name" value="Poly(ADP-ribose)pol_reg_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036930">
        <property type="entry name" value="WGR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008893">
        <property type="entry name" value="WGR_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10459">
        <property type="entry name" value="DNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10459:SF60">
        <property type="entry name" value="POLY [ADP-RIBOSE] POLYMERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00644">
        <property type="entry name" value="PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02877">
        <property type="entry name" value="PARP_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05406">
        <property type="entry name" value="WGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00773">
        <property type="entry name" value="WGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47587">
        <property type="entry name" value="Domain of poly(ADP-ribose) polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142921">
        <property type="entry name" value="WGR domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51060">
        <property type="entry name" value="PARP_ALPHA_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51059">
        <property type="entry name" value="PARP_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51977">
        <property type="entry name" value="WGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0013">ADP-ribosylation</keyword>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 15" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 15" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 15 21" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BRCT" evidence="17">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="WGR" evidence="20">
        <location>
            <begin position="199"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="PARP alpha-helical" evidence="19">
        <location>
            <begin position="327"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="PARP catalytic" evidence="18">
        <location>
            <begin position="462"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="90"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="299"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="140"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00033987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU362114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="CDM33072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="696" mass="77422" checksum="62275A7BA5C05F90" modified="2014-04-16" version="1">MAPRSFKNLVITVGGTFPNLRQVDLKTLIEGNGATFSTAVTDECTHLVTTEKDVEKQTTKYKQASQVANCHIVPLSWLLESAEAKKPLPESKYSFGQASQPDDDTQKTADAAPAENKRITRKRGADAAPAETQDTQKNGADSKAKPSEDKKPASKKRSATEDPVKNGSDKKTKDIQKTTKKTINVPVDEGFMEFGKIKDPKVYIDSAGLIWDATLSQTVSANNANKFYRIQLLSGTNSKYFTWTRWGRVGEHGQSACLGEGSLGAAMKHYEKKFRDKSGLKWVDRLDTPKNGKYTFLERNYEEDDEDEEPVKKEKTIKEEEDQPEVESALSKGLQNLMSFIFNKQDALDTLAAMSYDVHKLPLGKLSDRTLKSGFSALKEISELMITPSVAQAKYGQSYNDAIETLSNRYFTLIPHVFGRHRPPTLNTNAQIKKEIDLLEALTDMDVANEIMVSSKQGDDTHALDRQFQSLGMKEMTELDHKSTEFVELENYLKNSRGDTHNMSYKVVNIFRIERQGENDRFNTSPYASIPNSDRRLLWHGSRSTNFGGILSQGLRIAPPEAPVNGYMFGKGVYLADTSSKSANYCCAYNSRGMGLLLLCDAELGAPMLELVDSNYNAGEDARNSGKIATLGKGLNVPGGWKDAGCLNPALEGVKMPDVAIGSTHLSENRGLFYNEYIVYDVAQIRQRYLFQVKMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W6QYH3</accession>
    <name>W6QYH3_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NUC153</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PROQFM164_S03g001321</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat NOL10/ENP2 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QYH3"/>
    <dbReference type="STRING" id="1365484.W6QYH3"/>
    <dbReference type="OMA" id="GYFMDVR"/>
    <dbReference type="OrthoDB" id="273340at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056551">
        <property type="entry name" value="Beta-prop_NOL10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040382">
        <property type="entry name" value="NOL10/Enp2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012580">
        <property type="entry name" value="NUC153"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14927">
        <property type="entry name" value="NUCLEOLAR PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14927:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23098">
        <property type="entry name" value="Beta-prop_NOL10_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08159">
        <property type="entry name" value="NUC153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleolar protein 10-like N-terminal" evidence="6">
        <location>
            <begin position="19"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="NUC153" evidence="5">
        <location>
            <begin position="553"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="514"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="574"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="647"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="698"/>
            <end position="718"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF23098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM34597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="727" mass="80470" checksum="4179D73C7F84514C" modified="2014-04-16" version="1">MKLSNPSEVPVYTISGSDSARPLPEWLARRRKRSLKNDPEYANRVELLQDFEFEEASHCIRVSEDGDWVMSTGTYKPQIHTHYLPQLSLSWARHTSSLNTTFILLSSDYTKSLHLQSDRSLEFHTPSGCHYTTRLPRYGRDLVYDRQSTEVLVPAVGVNQDGMGEVYRLNLELGRYMRSFEVDVGGDDFTSTGGGTLQGGINTGAVNTGAIAEQSHNLLAFGTSLGTVELWDPRAKGRAGVLSTPTQLGLHDGRSEITALDFNRSGMSLGTGSSNGLIHLYDLRSPVPFQVKDQGYGFPIHTLQFLEPSSATQAATIEPKLLSSDKRIIKLWDIEDQKPWTSVEPAVDINSVAWCKDSGMLLTANEGRQQHSFFIPQLGPAPKWCSFLDNLVEEMAEDPNDPSAFKSAQSGSVWPGFTLVPSEEVAKWDAKLIKAGGDPIDLAAYMQSGKMVPYSKGYQVSNFVYNSITSLFPDTENPRAKKVAEIMNKERESRIRGKKKVAVKVNRRLAERMLNAEEKRERKHAKRLLEGSGDQEMVDAAATGEDKVLGGGRFAQLFEDQDFAVDETSREFQLLNPSTVPQAAAPSASRKERGLTAVEQEAIDEVPGSSSDSDSDNEAEKPVKAAVSKKISSADYKRTKRPPPRMQVSSSNQANSTRDRSFGSRAQNMKSKQKPARRVGVVGEQEMSFNPAGKPKRAAPEVRYDKTDTSFRAKERRSASGNTFRKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W6R1R0</accession>
    <name>W6R1R0_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S04</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S04g000623</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6R1R0"/>
    <dbReference type="STRING" id="1365484.W6R1R0"/>
    <dbReference type="OrthoDB" id="4363784at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF11">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM35742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="116" mass="12795" checksum="E043284B96850C1E" modified="2014-04-16" version="1">MASDVIYDTKKLAQDLGIYYMEMEAAGLMNDFPYLVIRGIYDYADSHKSKEWQGYTAAVAAAYAKELLLVVSIDYIGTAKASLRVVEAVIHDIPISTSLTELVDVARGKATVIQQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W6R6F2</accession>
    <name>W6R6F2_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Choline monooxygenase, chloroplastic</fullName>
            <ecNumber evidence="4">1.14.15.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PROQFM164_S06g000353</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the first step of the osmoprotectant glycine betaine synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>choline + 2 reduced [2Fe-2S]-[ferredoxin] + O2 + 2 H(+) = betaine aldehyde hydrate + 2 oxidized [2Fe-2S]-[ferredoxin] + H2O</text>
            <dbReference type="Rhea" id="RHEA:17769"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15354"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15870"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="EC" id="1.14.15.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine aldehyde from choline (monooxygenase route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the choline monooxygenase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.15.7" evidence="4"/>
    <dbReference type="EMBL" id="HG792020">
        <property type="protein sequence ID" value="CDM37392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6R6F2"/>
    <dbReference type="STRING" id="1365484.W6R6F2"/>
    <dbReference type="OMA" id="ARMEFDY"/>
    <dbReference type="OrthoDB" id="426882at2759"/>
    <dbReference type="UniPathway" id="UPA00529">
        <property type="reaction ID" value="UER00430"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019133">
        <property type="term" value="F:choline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019285">
        <property type="term" value="P:glycine betaine biosynthetic process from choline"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00680">
        <property type="entry name" value="RHO_alpha_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.380.10">
        <property type="entry name" value="Naphthalene 1,2-dioxygenase Alpha Subunit, Chain A, domain 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="entry name" value="Rieske [2Fe-2S] iron-sulphur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015879">
        <property type="entry name" value="Ring_hydroxy_dOase_asu_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001663">
        <property type="entry name" value="Rng_hydr_dOase-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43756">
        <property type="entry name" value="CHOLINE MONOOXYGENASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43756:SF3">
        <property type="entry name" value="CHOLINE MONOOXYGENASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00848">
        <property type="entry name" value="Ring_hydroxyl_A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="ISP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aromatic-ring-hydroxylating dioxygenase alpha subunit C-terminal" evidence="7">
        <location>
            <begin position="123"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="Aromatic-ring-hydroxylating dioxygenase alpha subunit C-terminal" evidence="7">
        <location>
            <begin position="188"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM37392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="320" mass="37048" checksum="633539C440352F5C" modified="2014-04-16" version="1">MSELVRTLPASWYCSQPLYQMERRAVFLKSWYLLGPVTRFQVVGEHVPYEIAQRSVSAVRTSGETLNPVDEELKVVCAKTGKELRSHLTPTGLLFSTISDDAPSFHEFFPELEELLGKVDFTKLPHRRSINYEGRFNWKTMVDGYQECLHCQYTHPSFSKYYPPTFYTVRNKHNFSQHIADPNKSDDGLFLYFFPNCTLNVYGGGMSCFRVCPTADPQVTRMEFDYFHLESGDKFEEYFKFVRQVAMEDFELCEKAQSNLARGVYHEGILNPNKENGVSYYQRRVFDMVCEQHEFDRTAKAAKESGLEEHVAPSMVQMAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W6R9P5</accession>
    <name>W6R9P5_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase-like domain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S28g000003</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792042">
        <property type="protein sequence ID" value="CDM38593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6R9P5"/>
    <dbReference type="STRING" id="1365484.W6R9P5"/>
    <dbReference type="OrthoDB" id="8300194at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM38593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="83" mass="9518" checksum="E44AD1517E0AB31C" modified="2014-04-16" version="1">MNGCKILEINSSTILKVGPVIQMAEVETLFLVRERTSVPVPEVFNAYTIADYGFILMSKIPGFSLAQCWEFDWRFQDFYCPTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2024-10-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W6PPX4</accession>
    <name>W6PPX4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g000037</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PPX4"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM26228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="86" mass="9195" checksum="E867291B4907F68B" modified="2014-04-16" version="1">MGRGSGFQKTNPPTGLLTKTRPDPWGGFSWAGSGFGAGLARSSNYIKTNSTSSITNVMWIQRLLAPADQVRRRIAIPISLGSGIEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W6PQX8</accession>
    <name>W6PQX8_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">mRNA-capping enzyme subunit beta</fullName>
            <ecNumber evidence="8">3.6.1.74</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">mRNA 5'-phosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">mRNA 5'-triphosphate monophosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PROQFM164_S01g000412</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">First step of mRNA capping. Converts the 5'-triphosphate end of a nascent mRNA chain into a diphosphate end.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a 5'-end triphospho-ribonucleoside in mRNA + H2O = a 5'-end diphospho-ribonucleoside in mRNA + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:67004"/>
            <dbReference type="Rhea" id="RHEA-COMP:17164"/>
            <dbReference type="Rhea" id="RHEA-COMP:17165"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:167616"/>
            <dbReference type="ChEBI" id="CHEBI:167618"/>
            <dbReference type="EC" id="3.6.1.74"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:67005"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="8">Heterodimer. The mRNA-capping enzyme is composed of two separate chains alpha and beta, respectively a mRNA guanylyltransferase and an mRNA 5'-triphosphate monophosphatase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the fungal TPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.74" evidence="8"/>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PQX8"/>
    <dbReference type="STRING" id="1365484.W6PQX8"/>
    <dbReference type="OMA" id="YFAQQRS"/>
    <dbReference type="OrthoDB" id="272147at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031533">
        <property type="term" value="C:mRNA capping enzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140818">
        <property type="term" value="F:mRNA 5'-triphosphate monophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004651">
        <property type="term" value="F:polynucleotide 5'-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006370">
        <property type="term" value="P:7-methylguanosine mRNA capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07470">
        <property type="entry name" value="CYTH-like_mRNA_RTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.100.10:FF:000002">
        <property type="entry name" value="mRNA capping nucleoside-triphosphatase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.100.10">
        <property type="entry name" value="mRNA triphosphatase Cet1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040343">
        <property type="entry name" value="Cet1/Ctl1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033469">
        <property type="entry name" value="CYTH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004206">
        <property type="entry name" value="mRNA_triPase_Cet1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037009">
        <property type="entry name" value="mRNA_triPase_Cet1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28118:SF1">
        <property type="entry name" value="POLYNUCLEOTIDE 5'-TRIPHOSPHATASE CTL1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28118">
        <property type="entry name" value="POLYNUCLEOTIDE 5'-TRIPHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02940">
        <property type="entry name" value="mRNA_triPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55154">
        <property type="entry name" value="CYTH-like phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0506">mRNA capping</keyword>
    <keyword evidence="4 8" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="mRNA triphosphatase Cet1-like" evidence="10">
        <location>
            <begin position="489"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="64"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="153"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="222"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="249"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="277"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="357"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="389"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDM26603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="780" mass="85246" checksum="ED46C75F17AB9405" modified="2014-04-16" version="1">MDLRTIMNTDGGASNPPPPSNSASSPISDQTPQKRPRKAASYSEYSTRPPQPPPLQHPQHASPERSSPYASVQSPYQQFSSAPVINTAVRSQRSQTPPHVSTPYGPGTRDPFGAPAYWSQPQHPGGGPLVSPYTPQPMSAGPQHPEQPSYFAQQRSQQRSQSLQSVMTTPRAPIESFRSPPVASQPLPSQHFSPAAHRSVTGTPLGPPAAFAARQSPSTARPPSSGHNSPGNPLSSPRPTREAPIRDQVPTQSPVTQRQFSPHSSQPPEPTRLPSGGSKQEPTESASPQSISRHNSIVTASESATAGQVRSSEDRMLVESPTAQKSTVAGSDFLTSPLAPGSQMNSSPSAHGGAHAVDMEIDHEPRVDIQQPKQKRRRYNEPPIYARLTPRNTNRRPIIPNPRPPIPKHARKSQQDPSVAVRRRSSSTKAVTPAARVTRALPIASPNTSVPRVQASPAPPAPSLRPPNSQVVGSLGPWEPSITGFIPHEEITKTLCDFLFQHVVMRNDVNTGPVGSVAAASQGTIIEIEAKLGHIIDLDSRERIHLPILTESVLNRENARIRTSFESNMTVEQHRAMNNFLNEAVKASMPQPNSTRIPLAYVHKKERDTFYEIQAADLPPVIRQNLNPRHKPKVRVTTDERTGEILAKIVKCRVADMDVCSPRTTVDWRVSVNLEMEYTGDVSNLPVIDAAVVKGARGDRIKDRMSYRHLAYQVDLTQVAKSDQQPGKNEFEHELEVEVSADEIRRQGKLAMSGDPKNQYEDLVKGFVDNIRLLARAVPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W6PR51</accession>
    <name>W6PR51_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Six-bladed beta-propeller, TolB-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g000482</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PR51"/>
    <dbReference type="STRING" id="1365484.W6PR51"/>
    <dbReference type="OMA" id="NANIWVK"/>
    <dbReference type="OrthoDB" id="43744at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011659">
        <property type="entry name" value="WD40"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32161">
        <property type="entry name" value="DPP6 N-TERMINAL DOMAIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32161:SF8">
        <property type="entry name" value="DPP6 N-TERMINAL DOMAIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07676">
        <property type="entry name" value="PD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004879161" evidence="1">
        <location>
            <begin position="19"/>
            <end position="677"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM26673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="677" mass="75359" checksum="1279C16C4C794178" modified="2014-04-16" version="1">MRLSIITVVGLAIAPVLANCPYARDAGSEVDNSANLHAHLPRDATRSKPTTGVASPLPSAAAGKKGLLLMNRIAPGTSELYIANADGTNERPLLKDPGYEYHAEFSPDGEWISFTSERDGDGNSDIWRVHPDGSDLQPIVKSPAAEDSVVISPNGTLAAYVSTANKYNANIWVKNLETGAEWNITDTPANRPDEDMMHGHFRPAWSPDGDWLAFSSDRNTIWDGHGKPTYLGLAGWEHTQELGIYIIRPDGSDLRLVAHRASHCLGSPKWSPDGKRLIFYEMTRNGTWDAHRPELVADGNSTIVSIGINGNDRRTEVGGPGIKTFPQYVTNSTIGYHLKGGDKEGLYLTNGTYVNTTIRSPSWSTDGKYVVYEKAVWSIRPLFKELYSWDSEWDYRFTDIFPQLSSNDRVAMTEKQLGNSSIATFDLEDRHASLVYKPNDTSLIDTTLIGEGLAGAYNPSWSPDGEWIVFGVGAWFEARDWRGGWILRSTANGSHTEVLTTSKLFINQTKYLNTGFPSFSHDGKKVVYRVWGAETAKYGDETEIGLRMIDIETREITQLTSGWDNLPSFSPDGEFIVFTRKVSPTNYDVCIIRPDGTDFRILTSSGANDAHAVWRQDGKIMWSSGMYGFQYECALYEETFQPYGQIMIMDPDGSNKRALTNSIWEDSMPLFLPNDWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W6PRL3</accession>
    <name>W6PRL3_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PROQFM164_S01g000200</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PRL3"/>
    <dbReference type="STRING" id="1365484.W6PRL3"/>
    <dbReference type="OMA" id="IWGTNNM"/>
    <dbReference type="OrthoDB" id="2988756at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF166">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="37"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="171"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="209"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="248"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="21"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM26391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="338" mass="37703" checksum="E1B64FCBDC0E6D39" modified="2014-04-16" version="1">MDSTLIILWVFTWVAIGLIVLRLLARKLRGYQFVLGDYFAMGAILCAVIRLALVHVILIWGTNNMSGTFRRTHVFTPEDIRRREIASKFVLTNRVFYNSYLWLQKLVLLDTYRRLLRQLRWEKVTMISYIGIFAATYVTVQTVTFTECDPFSHYWIVLPDPGKCCQAQLQLIVLVSSGVLNVITDIMLIALPIPILVLVKRSAVEKIQLAVLFAVGLFIVAITIVRLPQNVKNPTVQVNRTTWASVELLAAAIVANAPVLYGLLKGRSQRSKYAASGAGSTGPSWQGLQKRSANELELELQRISHSVGGPVLGSKISSSHYLEIDGGSSQSLTRSLDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W6PS49</accession>
    <name>W6PS49_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S01g000852</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PS49"/>
    <dbReference type="STRING" id="1365484.W6PS49"/>
    <dbReference type="OMA" id="PTWEEII"/>
    <dbReference type="OrthoDB" id="4192850at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM27043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="243" mass="28450" checksum="9F31258B331A83E6" modified="2014-04-16" version="1">MSNPTLKLRQKRSMMRLLNEGRSILEYKFDPSAFVVPRWILVPHEVRNAMVALQYKAMVAVYGMKSLMVTRDHRYFKLCPKSTGPIIYQLHQSSMHRLLEWKEDWSFANPTLAAAAKIPRDVLQFCVDSIAYGKFTCDYTNKIDGFMSGAFQSWRQLRIEIGHLAFRLMSHKPHEYNKWLVWWEGKFADDMWRWEVCLEGLILPTWEEIIDDVYLMINDRVENAQDLANTFYVSTPGLASTGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W6PS62</accession>
    <name>W6PS62_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">dihydropyrimidinase</fullName>
            <ecNumber evidence="6">3.5.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">PYD2</name>
        <name evidence="9" type="ORF">PROQFM164_S01g000400</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>5,6-dihydrouracil + H2O = 3-(carbamoylamino)propanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16121"/>
            <dbReference type="ChEBI" id="CHEBI:11892"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15901"/>
            <dbReference type="EC" id="3.5.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="PTM">
        <text evidence="7">Carbamylation allows a single lysine to coordinate two divalent metal cations.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.2" evidence="6"/>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PS62"/>
    <dbReference type="STRING" id="1365484.W6PS62"/>
    <dbReference type="OMA" id="FGFHFGI"/>
    <dbReference type="OrthoDB" id="1924787at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004157">
        <property type="term" value="F:dihydropyrimidinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01314">
        <property type="entry name" value="D-HYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000174">
        <property type="entry name" value="Dihydropyrimidinase-related protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011778">
        <property type="entry name" value="Hydantoinase/dihydroPyrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050378">
        <property type="entry name" value="Metallo-dep_Hydrolases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11647:SF1">
        <property type="entry name" value="COLLAPSIN RESPONSE MEDIATOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11647">
        <property type="entry name" value="HYDRANTOINASE/DIHYDROPYRIMIDINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="8">
        <location>
            <begin position="55"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-carboxylysine" evidence="7">
        <location>
            <position position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00036696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR611778-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM26591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="532" mass="58825" checksum="BB2F0528DD3FD16E" modified="2014-04-16" version="1">MAKFDLIIVNGKVVTASDISICCIGIKNGKIRALVDGFTDEEIEGVKVIDAQGAYVVPGGIDAHVHLCQDLKTGPHGLGGECADNFETGSRSAVAGGTTTMITFATQTRAEEDRSLLNVVKAYNSRAEATGSYADYGFHIIIVRNDADVLENELPVLMKDWGISSCKLFLTYETQKLTDSQLLDVMFAARKNFITTMIHAENGDMIQWLTNKLESKGMVAPYYHALSRPPLVEAEATNRAIALAHLIQNPILFVHVGSALGAANVRKAQTMGLPIYAETCPQYFHLTWDDLKRFHSPTCFENSKMICSPPPPPDISDQEDLFTGLQNGTFTIYSSDHCPFRYDHPNGKPSGVLEHEPSMEGEKHCHGDELQNLLERKEGTFRLIPNGIPGVETRLPLLYTGALATGRITAQKFVELTSTNPAKLYGLYPTKGTIMPGSDADLVIWHPDKDFVPFRLTNSMLHHNVDYTPYEGMEFVNWPKYTILRGNIVWADGEVQGKPGDGKYLKRGPSQLSRSFSKTSADPRYVASWLYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W6PS89</accession>
    <name>W6PS89_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ankyrin repeat-containing domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g000430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PS89"/>
    <dbReference type="STRING" id="1365484.W6PS89"/>
    <dbReference type="OMA" id="WDINEPV"/>
    <dbReference type="OrthoDB" id="426293at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051616">
        <property type="entry name" value="Cul2-RING_E3_ligase_SR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46224">
        <property type="entry name" value="ANKYRIN REPEAT FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46224:SF64">
        <property type="entry name" value="IQ MOTIF AND ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="161"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM26621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="200" mass="22444" checksum="B5FD5C0D4F1B6F1E" modified="2014-04-16" version="1">MYSNSLDIVDLHDIIIEVIHLGRVEFVSLLLSHGFPIKPSFTREAIVFKVKRVLECFLEAGYAVTDVEMTRWFLEHGTNPNTSCEVDCTPLSYTIRNARLSVIKLMLDHRGDVRKGQLLQYAVCRDEGLEDIISLLVERGAPLNATMYKDGQTLIHFYPISLGTALHTATEQGKMNAIRLLKHLGADTEVKDANGDTTLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>W6PSW1</accession>
    <name>W6PSW1_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Winged helix-turn-helix transcription repressor DNA-binding</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PROQFM164_S01g000625</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the HSF family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PSW1"/>
    <dbReference type="STRING" id="1365484.W6PSW1"/>
    <dbReference type="OMA" id="SALWEFK"/>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000229">
        <property type="entry name" value="HSF-type DNA-binding domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000232">
        <property type="entry name" value="HSF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015:SF396">
        <property type="entry name" value="FLOCCULATION SUPPRESSION PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015">
        <property type="entry name" value="HEAT SHOCK TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00447">
        <property type="entry name" value="HSF_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00056">
        <property type="entry name" value="HSFDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00415">
        <property type="entry name" value="HSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00434">
        <property type="entry name" value="HSF_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HSF-type DNA-binding" evidence="6">
        <location>
            <begin position="129"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="392"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="392"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="436"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="516"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM26816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="558" mass="61416" checksum="B1C0CED0490F3391" modified="2014-04-16" version="1">MSRLADPPSTRISFAGVSDAPGRTRNIPVLSSSGQHSMDITPPPTGAHGSDDRMTGITNGAEAGNNLLTAPNAAIGAAAAAQQPKVVQTAFIHKLYNMLEDPSIQHLISWSGTNDSFVMSPTSEFSKVLASYFKHTNISSFVRQLNMYGFHKVSDVFHTGSPDSALWEFKHGNGNFKRGDLAGLREIKRRASRHALIHRDSFPGHKAPVSQPGTPAEPVHDATEARFLNIEQTFYDLRNRMARAEEGNITLNSRCHAMTESLTKCYQWTHSISRFLQAVVPDRESPLHRDVSSMQREVEKHIEIMRAMETPHETLMPPRQQYFANMTEAGPPLSPRQMPQDDARRQSMMDHTPRHTNMIRPPVPPHLSVSPRRYGSIGGAPSASAYARLQPPVAPPAQQPMPHPLSVSTSPGPNLTRRHTSADIRQHGWSPSAGSPYPPGNPPNGPWPSSPGHRTPVSSDQQVRDVLAQYEMGAPRRLREQSRHATPPTAEPSPSMLGVDNGWTLGGSRFPHGSSLPATRRSSMASNVHSLLNPADTAERPDEDQQAMSEDRKRKRLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W6PTG0</accession>
    <name>W6PTG0_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g001299</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OMA" id="EFYMCMV"/>
    <dbReference type="OrthoDB" id="10010954at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="212"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="248"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM27488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="291" mass="33076" checksum="21B36251553AE13D" modified="2014-04-16" version="1">MDLSKRHPHPIPLGTKQLGPISDLAPFSALIISLVLVIFFLVRFYVLEGFLIRRLYGSIYTEMSELNRRGFVNHHIAGVTKVIILVVAAYPFISVAFCKGPSFNTPFVKGSVVTLGDMLIVVAQILIGIYIFELIYRVKLSPVAVMHHVGTIFIGQAAIAISLRPLREPDTYIEFVLCTVWGAFDAVFELFPHFAIILYRVFPRRHQLLSRIFLISCFSTAVGTLTETVVTMWLFGSTWDRWRLAFKVVTPVLHLAFSAAQIHGSLVFWRMYRRQKRFQKEADTEAELLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W6PUI6</accession>
    <name>W6PUI6_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S01g001232</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PUI6"/>
    <dbReference type="STRING" id="1365484.W6PUI6"/>
    <dbReference type="OMA" id="DDWRKTN"/>
    <dbReference type="OrthoDB" id="37537at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050791">
        <property type="entry name" value="Aldo-Keto_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625">
        <property type="entry name" value="AFLATOXIN B1 ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625:SF40">
        <property type="entry name" value="ALDO-KETO REDUCTASE YAKC [NADP(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="21"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM27421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="349" mass="38182" checksum="9B73E474E651D755" modified="2014-04-16" version="1">MAPKFTKLRPLGKNGPLVPAIGYGMMVMTSPSYGASLEDDQRLALLDRAVEIGATFWDTADMYGDNEKLLAQWFKRSGKRDQIFLASKFGYVKGSHTLEIDTSAAYTKKACYSTLENLGIEYLDLSNAALDYVHNVDKVTPIEETMRALVELQAEGKIKHIGLSVVSSSTIRRAAKIAPITAYQPGYSLFERLIEGPEGTHALATCRELGIAIVCATPLGRGILTSGFSQGKAIGAEADIREKMMPQFQDGAKEHNADLARQIKIVADRKGCSLSQLALAWLLKQGDDIFPIPGTKRIKYLEDNMGALDVNLTDEEEAEIRALVEKTPVVGSSVPDAFTGMLFRDTKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W6PUR1</accession>
    <name>W6PUR1_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S01g001317</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PUR1"/>
    <dbReference type="STRING" id="1365484.W6PUR1"/>
    <dbReference type="OrthoDB" id="566138at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM27506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="92" mass="10273" checksum="F48DE2C8462A937C" modified="2014-04-16" version="1">MEHLGHGNTRLSQNYSCDVLLVTSSTDLPLDLGRLQGIQVPLGFSADREIVRKFKGMVMKATNILYGITLTGRRLSEEFLPVRMHLSKLSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W6PUR3</accession>
    <name>W6PUR3_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g001441</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PUR3"/>
    <dbReference type="STRING" id="1365484.W6PUR3"/>
    <dbReference type="OMA" id="SEDSWIM"/>
    <dbReference type="OrthoDB" id="5412996at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM27630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="113" mass="13466" checksum="758BF1848BEE3CDB" modified="2014-04-16" version="1">MNDSWESGDFWILYAALHSFAFDGIYWQKIDSRFFGPTESIEDAWKERLDLLDEGQKDEMELLLDRKLQEMNTRVLSWDPDAYTLAFHQQSKSQEEKANEEKGKREEQTEEHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W6PV11</accession>
    <name>W6PV11_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="5">p53-like transcription factor, DNA-binding</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PROQFM164_S01g001541</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PV11"/>
    <dbReference type="STRING" id="1365484.W6PV11"/>
    <dbReference type="OMA" id="HQTINPE"/>
    <dbReference type="OrthoDB" id="2288358at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000228">
        <property type="term" value="C:nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1390">
        <property type="entry name" value="NDT80 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052605">
        <property type="entry name" value="Fungal_trans_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024061">
        <property type="entry name" value="NDT80_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037141">
        <property type="entry name" value="NDT80_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008967">
        <property type="entry name" value="p53-like_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35144">
        <property type="entry name" value="MEIOSIS-SPECIFIC TRANSCRIPTION FACTOR NDT80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35144:SF2">
        <property type="entry name" value="MEIOSIS-SPECIFIC TRANSCRIPTION FACTOR NDT80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05224">
        <property type="entry name" value="NDT80_PhoG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49417">
        <property type="entry name" value="p53-like transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51517">
        <property type="entry name" value="NDT80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NDT80" evidence="4">
        <location>
            <begin position="173"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="NDT80" evidence="2">
        <location>
            <begin position="173"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="309"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="432"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="489"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="547"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="309"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="342"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="504"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="559"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDM27730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="587" mass="64428" checksum="A69CC19371B5A788" modified="2014-04-16" version="1">MNPSLLSEVFSLNDPVTSEGDYMNSHVTGFGTDEDDNSQRVGGLVSMPDTNGVRYHAQHPLMQDLQYSSSGALAMTPPDSCPDSFSPTSGPLFPHISRLQHPFDRMADYQRVPALQPPTGMPTGMQSSGHALNSIPALMGRNNSYGSYALQRGIGNIGLPMGGMNDLSRHGYPGTPRALDSGMDRSQNNMYQQPIVESPQRSQPQIEAPPFDDTTILHTVVAEFGGQYQTVKPDVQAKMGRGPFPAEGKWTCYRRNYFAVTCGFGLHPWPPNAPLYIRYPDQTLEPIRGFSMAISAIVNGQYGETRELVQHTPKRDKQSERKPGRVILQPAPPPSFTSTSTVNGSLSGFPLGSQSMDYNPSFTGTPQPCQPPTSHVFERIQFQKATANNGKRRAQQQYYNLVVELYAEVASSVPGETEWVQIARRHSHPLVVRGRSPGHYKDGRRGSTGSMGPDGAGGDNTCGVIPHGLGQTGRSHMLVYDTSHRNGLSYGRSDHRKINVTDHSPLSDSPLISSSSSSGFEYSMIDTMDPMDTIKSDLYLKSDPYQDNTYTGVPHQHRQSNTGGYDPVYSTNYSRYDPIQNSHSLCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W6PV72</accession>
    <name>W6PV72_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g001571</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PV72"/>
    <dbReference type="OMA" id="DCKDAYQ"/>
    <dbReference type="OrthoDB" id="5144514at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006771">
        <property type="entry name" value="CetA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36195">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G01990)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36195:SF6">
        <property type="entry name" value="SECRETED THAUMATIN-LIKE PROTEIN CALA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04681">
        <property type="entry name" value="Bys1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004879780" evidence="1">
        <location>
            <begin position="18"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM27760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="176" mass="18294" checksum="FD3602C9233A3861" modified="2014-04-16" version="1">MTFNVFLTGLLAATAAAVPLSARSGESGAVQTRDSGGGGLQIVNNMGKDLYLWTTSSDAGSMQTISSGGDHSEDWTTNSNGGGISIKLSTSETKDSVLQFEYTQNGDTLFWDMSSIDLDASSDFVKAGFTVVPSDSSCKTVSCAAGDADCKDAYQLPDDVNTYSCSLSADFTLTLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>W6PVK9</accession>
    <name>W6PVK9_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="7">PPIase</shortName>
            <ecNumber evidence="7">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PROQFM164_S01g001612</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 7">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the cyclophilin-type PPIase family. PPIase B subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="7"/>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PVK9"/>
    <dbReference type="STRING" id="1365484.W6PVK9"/>
    <dbReference type="OMA" id="HPGDRPK"/>
    <dbReference type="OrthoDB" id="193499at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01926">
        <property type="entry name" value="cyclophilin_ABH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000001">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 7 11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0697">Rotamase</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004879216" description="Peptidyl-prolyl cis-trans isomerase" evidence="7">
        <location>
            <begin position="24"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="10">
        <location>
            <begin position="39"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="200"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="200"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDM27801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="265" mass="29537" checksum="00747858B890B8B5" modified="2014-04-16" version="1">MYFRNLLVSLFFVFAVGFALVQAQEAKEPRGPKITSKVYFDIQHGDEPLGRIVMGLYGKTVPETAENFRALATGEKGFGYQDSTFHRVIKDFMIQGGDFTKGDGTGGKSIYGNKFKDENFKLRHTKKGQLSMANAGKDTNGSQFFITTAITSWLDGRHVVFGEVLEGYEVVDKIQNVPKGSGDRPKLAVKIVKSGELELEPETEEKELDQEPSVTENAPDAPEATPSYLLQLVVIFFVLVAAVGIWIARRRGQQQEQEKEKQYDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W6PW74</accession>
    <name>W6PW74_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 15">Dipeptidyl peptidase 3</fullName>
            <ecNumber evidence="4 15">3.4.14.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13 15">Dipeptidyl aminopeptidase III</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14 15">Dipeptidyl peptidase III</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PROQFM164_S01g001847</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>Release of an N-terminal dipeptide from a peptide comprising four or more residues, with broad specificity. Also acts on dipeptidyl 2-naphthylamides.</text>
            <dbReference type="EC" id="3.4.14.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15 17">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="15 17">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the peptidase M49 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.14.4" evidence="4 15"/>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PW74"/>
    <dbReference type="STRING" id="1365484.W6PW74"/>
    <dbReference type="OMA" id="QRYWIRD"/>
    <dbReference type="OrthoDB" id="4694525at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.540.30:FF:000001">
        <property type="entry name" value="Dipeptidyl peptidase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.540.30:FF:000002">
        <property type="entry name" value="Dipeptidyl peptidase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.540.30:FF:000004">
        <property type="entry name" value="Dipeptidyl peptidase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.540.30">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005317">
        <property type="entry name" value="Dipeptidyl-peptase3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039461">
        <property type="entry name" value="Peptidase_M49"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23422:SF11">
        <property type="entry name" value="DIPEPTIDYL PEPTIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23422">
        <property type="entry name" value="DIPEPTIDYL PEPTIDASE III-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03571">
        <property type="entry name" value="Peptidase_M49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007828">
        <property type="entry name" value="Dipeptidyl-peptidase_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 15" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="7 15" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 15 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 15" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="8 15" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 15 17" id="KW-0862">Zinc</keyword>
    <feature type="active site" evidence="16">
        <location>
            <position position="499"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="498"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="503"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="557"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR007828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR007828-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR007828-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CDM28036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="755" mass="83977" checksum="E04BC7DC210FE8E8" modified="2014-04-16" version="1">MHSMRGIAPHLSSRSSVSPLLPLHRISRRLTPRLAKTFSSYTHLTRDAMDLSIKQHYLADSPPTVVRLEVKSHFDTLKDQNLRKYAHFMSRAAFEGTRVTLRQVSPESEPIYDLILSLYHAANGDWNSLAQKTQVSPDDLRFFLEYASQFLGNCGNYKGFGDSKFIPRLSVSAFEALASATAETKAAFQKANTTGGGIYETSEGSMMHLGYPKGGHMTTYYPDSPTISKEEITAVGDLMEKKGLALENTRLRKTSSGDFELLIASGVSSPPVRDRDLGDVDTFELDGDLKGKKLRLVFGDHQEEMAKIAHSIKQAELSAANDNQKKMLDSYALSFGAGSIEAFKESQRIWVKDQKPVLETNLGFVETYRDPHGVRGEWEGFVALVNLERTRAFGTLVDSAESMIPKLPWGKDFEKDKFLSPDFTSLEVLSFAGSGLPAGINLPNYDDIRQNLGFKNVSLGNVLSAKAPNEAIPFIAENDQEVYRSFRDPAFEVQVGIHELLGHGTGKLLQETAPGEYNFDIKNPPISPVTNKPISTWYKPGQTWSSVFGSIASSYEECRAECVAMVLGCDFGILKIFGFGDGKEDLAGEAGDVLFAAYLSMARAGLVALEFWDPKTQKWGQAHMQARYSILRTFLDAGDDFVKLSYKKEDLSDLEIHLDRSKILTHGRPAVEKYLQKLHVYKSTADIEAGKGLYDDITSVDSWWGTSVREVVLKKKVPRKIFVQANTILEGDQVTLKEYEPTLEGLIQSYAERNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>W6PWJ6</accession>
    <name>W6PWJ6_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">cysteine desulfurase</fullName>
            <ecNumber evidence="3">2.8.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">NFS1</name>
        <name evidence="13" type="ORF">PROQFM164_S01g002086</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the removal of elemental sulfur from cysteine to produce alanine. It supplies the inorganic sulfur for iron-sulfur (Fe-S) clusters. Plays a role in both tRNA-processing and mitochondrial metabolism. Involved in the 2-thio-modification of both 5-carboxymethylaminomethyl-2-thiouridine in mitochondrial tRNAs and 5-methoxycarbonylmethyl-2-thiouridine (mcm5s2U) in cytoplasmic tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(sulfur carrier)-H + L-cysteine = (sulfur carrier)-SH + L-alanine</text>
            <dbReference type="Rhea" id="RHEA:43892"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="EC" id="2.8.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.7" evidence="3"/>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PWJ6"/>
    <dbReference type="STRING" id="1365484.W6PWJ6"/>
    <dbReference type="OMA" id="KGLYWAR"/>
    <dbReference type="OrthoDB" id="10250117at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990221">
        <property type="term" value="C:L-cysteine desulfurase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031071">
        <property type="term" value="F:cysteine desulfurase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044571">
        <property type="term" value="P:[2Fe-2S] cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034227">
        <property type="term" value="P:tRNA thio-modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000003">
        <property type="entry name" value="Cysteine desulfurase IscS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000002">
        <property type="entry name" value="Cysteine desulfurase IscS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00331">
        <property type="entry name" value="Cys_desulf_IscS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020578">
        <property type="entry name" value="Aminotrans_V_PyrdxlP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010240">
        <property type="entry name" value="Cys_deSase_IscS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02006">
        <property type="entry name" value="IscS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010611">
        <property type="entry name" value="PRK14012.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11601:SF34">
        <property type="entry name" value="CYSTEINE DESULFURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11601">
        <property type="entry name" value="CYSTEINE DESULFURYLASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00595">
        <property type="entry name" value="AA_TRANSFER_CLASS_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class V" evidence="12">
        <location>
            <begin position="108"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00050776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDM28275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="507" mass="55438" checksum="41C65D113B6D272A" modified="2014-04-16" version="1">MTSAVPTAWRQASAFSRRLSTYGSRAPRVLATGLRGARSYVSETKVGQAQVNIETAIKEEQKAFMNQSHMAPQSVKLPGSATSGDAALSPSAGILKQATVMDQGTRPIYLDMQATTPLDPRVLDAMLPYLTGIYGNPHSRTHAYGWESEKGVEEAREHIAKLIGADPKEIIFTSGATESNNMSLKGVARFFGRSGKKNHIITTQTEHKCVLDSCRHLQDEGFEVTYLPVQSNGLIRMSDLEEAMRPETCIVSVMAVNNEIGVIQPMEEIGRLCRSKKVFFHTDAAQAVGKIPLDVNKLNIDLMSISSHKIYGPKGIGACFVRRRPRVRLDPLITGGGQERGLRSGTLAPSLVVGFGEACRIAAQDMEYDTKHIDRLSKRLSEGLLAMEHTTLNGDPEHHYPGCVNISFAYVEGESLLMALNDIALSSGSACTSASLEPSYVLRALGSSDESAHSSIRFGIGRFTSDEEIDYVLKAVQARVSFLRELSPLWELVQEGVDLNTIEWSQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W6PXQ1</accession>
    <name>W6PXQ1_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S01g002536</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PXQ1"/>
    <dbReference type="OMA" id="WQHEISS"/>
    <dbReference type="OrthoDB" id="3796275at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM28725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="234" mass="26713" checksum="98C642306F66ADE5" modified="2014-04-16" version="1">MHSLSKIDLALHEWQSFYQDVVAKYDSHNGTWDPAVIEAIVIGGSFSVATEQVLVGDDLGVRRRFHERNRQAVTTVLQIQGYNLRFADYKAARPTPFTGVPDFVVLDSSRAIKVVGEAKTPWDRLKVNMLDAAIIKFEQGNEKKLGRYLGQLAGQMRERDLKYAFLTTYDETVFVRKVDVESDWGLGYSPVIRHDDTFGQALSGQTFSETLPQCSNHRTMSKVLRFMEQEQRYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W6PXQ6</accession>
    <name>W6PXQ6_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ureohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PROQFM164_S01g002829</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the arginase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PXQ6"/>
    <dbReference type="STRING" id="1365484.W6PXQ6"/>
    <dbReference type="OMA" id="DEHCAGP"/>
    <dbReference type="OrthoDB" id="288726at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008783">
        <property type="term" value="F:agmatinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033389">
        <property type="term" value="P:putrescine biosynthetic process from arginine, via agmatine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.10">
        <property type="entry name" value="Ureohydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006035">
        <property type="entry name" value="Ureohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020855">
        <property type="entry name" value="Ureohydrolase_Mn_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11358:SF30">
        <property type="entry name" value="AGMATINASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11358">
        <property type="entry name" value="ARGINASE/AGMATINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00491">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01053">
        <property type="entry name" value="ARGINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51409">
        <property type="entry name" value="ARGINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDM29018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="108" mass="12186" checksum="A3020DAFBCD80085" modified="2014-04-16" version="1">MIDKIRINDIIRRIVNTVGDNYVYISIDIDVLDPAFTPATGTIEPGGWTRRELLRILYGLSQAGLPIIGVDVVEFAPMYDNKAETTVITVTQIIYELLRWMVHVPVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W6PXY2</accession>
    <name>W6PXY2_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Stress-responsive protein Ish1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S01g002616</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PXY2"/>
    <dbReference type="STRING" id="1365484.W6PXY2"/>
    <dbReference type="OMA" id="WTFDTWN"/>
    <dbReference type="OrthoDB" id="2527403at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018803">
        <property type="entry name" value="Ish1/Msc1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10281">
        <property type="entry name" value="Ish1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005716462" evidence="2">
        <location>
            <begin position="21"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="487"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="493"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM28805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="512" mass="57424" checksum="29B7D107DB501B9E" modified="2014-04-16" version="1">MKLNLATGLICLLASTEVVAASSWWNKALYNKWHETELERWLSDHNIPYPSPADRRDLENLVKTNWDSRVQTPLGQAVDNVNHELHHAREWIFDSWSDSQLKAFLDRHGIPAPQPRRHDLLVKTARENYEKIATKVGQTAAYPGDWLYAEWSDSDLKEWLDERGWPVPQPSERDKLIASVRRNSRIFSLQTQSIAASASAEAEAVKETLSNQLFNAWSDSKLKEFLDEHNVKVPQGSKRNELIALARKNRHYLSDQVSSASSAVEGAFGAATTKAGNEYAQATDYAKLKIDDAFETALNGWSDSRLKAFLDARSVPVPQNGKRDELVAKVRANAHKAAGGWNQYNFDTWDKEHLVNYLSSVNHKAIKQADASREQLVKSAQDSYAKASKAGGEQYASATSSIAHATDTAKDATFDQWSHSELKEYLDDYGVPTYQGSSINELRAAARRNAHYYKYGTASPQATIYAKVMSVLQWFADQLKIGAASGRAQGTEAAEKVQKKVSEHTERLREEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W6PY25</accession>
    <name>W6PY25_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transcriptional activator of proteases prtT</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Zn(2)-C6 zinc finger-containing protein prtT</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PROQFM164_S01g002681</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the prtT family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PY25"/>
    <dbReference type="STRING" id="1365484.W6PY25"/>
    <dbReference type="OMA" id="STTITHC"/>
    <dbReference type="OrthoDB" id="2595934at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF34">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR OF PROTEASES PRTT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="11">
        <location>
            <begin position="9"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00041135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00042461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDM28870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="602" mass="67454" checksum="414B4CA740332FC9" modified="2014-04-16" version="1">MPTKRRILSCQPCRRLKTRCEVLPGSRQCARCISLRLECSLPSTSAITSPDSGSIGRSDRNSAQPIACHCAARLDAIETSLSEMKELLKSHLLGNDRSMARHPANEMRETSSNLNPRKDINDSKATMHVPSEADISATTDIQPAPITVVRHVGSLITEPVTTGENDSLRGNMTEMGLDSDSFSSVFQHGFEQIASWYPFPNETLTDLKQNHPLLFAMCLLAGIRATAGLNRTNLHITLHTLVKTHLGMKTLDTPIDLSTIHAMLIFSAWSFGPLVPGGRYIDSWLMSSTTITHCMLSFPLSELVSLVGLYDETNRNMCRMWIQASLVHLKYAIGTGRPSVVPCERLHQWTEIVKYPGFETFDHIIAAELKLYIHLYEAIYHTVSSVTEAWDMVNRWGRKYLGGEQVKLSVMQLYSYSDIQNTDGSNILRWAHSCVSLILSRWELAKQNQSTSPDSLMRTERINELTETVIRHAQLVLREILVLCTSDTAFVRPTYDYLLTAYAGVTLAEYCSSISDVHATYTLMEDVRTQARIPKSIEGVFSWATNVVQKKAKDLLDSKVAVIPDDTFYSYPGSVADWAPFRFIDSMPASEWDGMNGSMQHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W6PYR4</accession>
    <name>W6PYR4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S01g003220</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PYR4"/>
    <dbReference type="STRING" id="1365484.W6PYR4"/>
    <dbReference type="OMA" id="NIGENEH"/>
    <dbReference type="OrthoDB" id="4453902at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM29408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="306" mass="35845" checksum="3438216CFF7ED2E1" modified="2014-04-16" version="1">MAEAQPQPHKFLRSLFRCIEYFEPDFPSPEYLYALGIQAFEVLLDPDKCGTFQFSPSFFQPHPDRLLQLYPPRPDVQEQEEFLRLSPIPSVQDIMNDSDIDYSPEVAPTFANLHRYDINRYEMVNDALAQARQTEKIIDCHMTIPSLNDPLRKWWRVMNQYRYIDRPRKPHLVMTCISNVRPTNTNRGITIHELKAIVSTFIRRVNHRPFIECQFHPVLVSSFMGEKLGRIIQASDDGQEIVLQYSQLWSFTDEETAPVKMFLRYRLSEAVGGYVCSRDGQQHWHGDARSLDCGRVRFKLPSLSFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q081</accession>
    <name>W6Q081_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Coatomer subunit beta'</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PROQFM164_S01g001435</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 13">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Cytoplasmic vesicle</location>
            <location evidence="1 13">COPI-coated vesicle membrane</location>
            <topology evidence="1 13">Peripheral membrane protein</topology>
            <orientation evidence="1 13">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Golgi apparatus membrane</location>
            <topology evidence="13">Peripheral membrane protein</topology>
            <orientation evidence="13">Cytoplasmic side</orientation>
        </subcellularLocation>
        <text evidence="13">The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the WD repeat COPB2 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q081"/>
    <dbReference type="STRING" id="1365484.W6Q081"/>
    <dbReference type="OMA" id="YVDYYPQ"/>
    <dbReference type="OrthoDB" id="10261470at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22947">
        <property type="entry name" value="Coatomer_WDAD_beta-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000016">
        <property type="entry name" value="Coatomer alpha subunit, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.470:FF:000001">
        <property type="entry name" value="Coatomer subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006692">
        <property type="entry name" value="Beta-prop_COPA/B_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050844">
        <property type="entry name" value="Coatomer_complex_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016453">
        <property type="entry name" value="COPB2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056176">
        <property type="entry name" value="TPR_COPA_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19876">
        <property type="entry name" value="COATOMER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19876:SF2">
        <property type="entry name" value="COATOMER SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04053">
        <property type="entry name" value="B-prop_COPA_B_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23953">
        <property type="entry name" value="TPR_COPA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005567">
        <property type="entry name" value="Coatomer_beta'_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 13" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="7 13" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="9 13" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 13" id="KW-0653">Protein transport</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 13" id="KW-0813">Transport</keyword>
    <keyword evidence="5 14" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="14">
        <location>
            <begin position="93"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="14">
        <location>
            <begin position="136"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="14">
        <location>
            <begin position="180"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="14">
        <location>
            <begin position="224"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="COPA/B second beta-propeller" evidence="16">
        <location>
            <begin position="318"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="domain" description="COPA/B TPR" evidence="17">
        <location>
            <begin position="594"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="816"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="834"/>
            <end position="844"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR005567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF04053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF23953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CDM27624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="877" mass="97226" checksum="5D9F227305760073" modified="2014-04-16" version="1">MRLDIKRQLFARSERVKGIDFHPTEPWILTTLYSGHVYIWSYESQSIIKTFELTDVPVRAGRFIARKNWIVCGSDDFQLRVYNYNTSEKITSFEAHPDYIRSIAVHPTQPFVLTASDDMTIKLWDWEKGWKCVQVFEGHSHYVMGMAINPKDTNTFASACLDRTVKIWNLGSPHANFTLEAHETKGVNHVDYYPQADKPYLLTTSDDKTVKIWDYTTKALIATLEGHTSNVSFACYHPELPVIISGSEDGTIKIWHANTYRLEQSLSYGLERAWCVSYQRGRQGIAMGFDDGAVVVKMGREEPAVSMDGSGKLIWARHSEVVSSVIKGGDASVKDGEPLSLPTKDLGQCEVYPQTLSHSPNGRFVSVCGDGEYIIYTALAWRNKAFGQALDFAWGAKDNSNDYAIRESSTSVKIFKNFKEQSAGLDVGFQAEGLSDGVLLGVKGQGGIGFFDWETGSLVRRIEADPKSVYWSESGELVTLACEDDFYVLRYSREDYINGLNAGEADEDGVEAAVELVATINETVRTGQWVGDCFIYTNSTNRLNYLVGDQTYTISHFDQPMYILGYLPRDGRIYLADKDVNAVSFSLSLSMLEYQTVVLRGDMEMASELLKDVPQDQMNKVARFLEGQGYKEMALEVATDPEHRFELALALNDLETALTIAREANVEHKWKIVGDAALAGWNLALAQECFTNAKDVGSLLLLHTASNNREGLKALAAQASESGLHNVAFSTLWSLGDIDGCIALLIQTNRIAEAVLLAQTYKPSSAPKLVVQWKESLEKSGKTKVARLIGVPPGAPDVASTDDDLFPEWDEYIRLEKEGNVPEPPSSESLIDINGDEEEEEAEAEPVSATNGALEADEEVEKADKAAVDEADAAEAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q0Q5</accession>
    <name>W6Q0Q5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S01g001590</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q0Q5"/>
    <dbReference type="STRING" id="1365484.W6Q0Q5"/>
    <dbReference type="OrthoDB" id="4364221at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM27779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="104" mass="11515" checksum="8BBD7F0E2634BA5B" modified="2014-04-16" version="1">MNSTCGYIHIEEGQDRLTVYLALELGIGLSDTTKGNVSALVPLESLTDTFTGITLSLVATTRPNFSRQFLRSAVSDTEKDLKCCQLMIQCYPRTNCIHTTRNLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2024-10-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q0R5</accession>
    <name>W6Q0R5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g001605</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q0R5"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM27794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="129" mass="13822" checksum="0872E03B8F6587E1" modified="2014-04-16" version="1">MSLASPSKAGGDQIPPILGKTPSAQANSVSEFRPRGGSCTVHTFYNMLPQCTSPVHARALWLCSRRLSPSFTGDRHVQKTHVTRSRDSVAGAGMDLRPPLDRGLLAIRHMATGLAGWNGPCGFTTFCTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q0Z3</accession>
    <name>W6Q0Z3_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PROQFM164_S02g000367</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q0Z3"/>
    <dbReference type="STRING" id="1365484.W6Q0Z3"/>
    <dbReference type="OMA" id="RNRWHIG"/>
    <dbReference type="OrthoDB" id="72851at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06421">
        <property type="entry name" value="CESA_CelA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050321">
        <property type="entry name" value="Glycosyltr_2/OpgH_subfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43867:SF7">
        <property type="entry name" value="CELLULOSE SYNTHASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43867">
        <property type="entry name" value="CELLULOSE SYNTHASE CATALYTIC SUBUNIT A [UDP-FORMING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13641">
        <property type="entry name" value="Glyco_tranf_2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="360"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="492"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="533"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="588"/>
            <end position="610"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM30218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="611" mass="67808" checksum="5F503601F526740A" modified="2014-04-16" version="1">MFPNNVYDIEELSPDDRALYAQKYRKYLRRIAQAAIWTTYIYFTVRLFFTVMSPEQTWQRWLMLGVEGLFAHISLNHQRLSLAATTKPPHQTLRKRLRSNENLPRVDVLVTCCGEPVEIILDTVRAACGLDYPASRFRVRLLDDGASTDLHDAIAKLATKWTHLSYHTRGKQSGQSFAKAGNLNYALFSLQTEDPPEFCTVVDADSILMPEFLRATLPHLLEDPKAALLTTRQYFYNLPCGDPLSQSRAYFYTCENTELDLLGHALDAGSGAVFRRDAILDAGGYPTYSFSEDWQLSLILRGLGKRTMQVQEVLQFGLVPTSLAGHLKQRNRWHIGHSQQISVLLPSVNKAIPEHLRWDIALGGLSIMAGLVTYSIGFVALPFLLVSDGGFIPAGSALEVKIQLVLAIVHVASTWAYDWARSAHAGVPFAPFAHAENSWLSTAHLYAIARFHLFGSKPKGSFVTGSTANSSENATSISSFQKAYRDTLQSGALLNICLFIATVGAMLFAIWVAVTGDGTEIPKLLTTFAWPPLLHLCFLTIVHNWVPIAHLFNSPAYHPRDSRLLTTEKEISYPRAEIEEELSSETPLLGLCCSFIVPVVLLGALAGVLIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2024-10-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q143</accession>
    <name>W6Q143_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S01g003503</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q143"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM29691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="68" mass="7718" checksum="EBE0606214B79726" modified="2014-04-16" version="1">MKEDISLHNARECNPRQELCITSQRRGADGLAMFEDEVFVNRVEGLVRLVDASPERAVFAWLLRTLGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q1A5</accession>
    <name>W6Q1A5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Six-bladed beta-propeller, TolB-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S02g000259</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q1A5"/>
    <dbReference type="STRING" id="1365484.W6Q1A5"/>
    <dbReference type="OrthoDB" id="9977941at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052998">
        <property type="entry name" value="Hetero-Diels-Alderase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42060">
        <property type="entry name" value="NHL REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42060:SF3">
        <property type="entry name" value="SMP-30_GLUCONOLACTONASE_LRE-LIKE REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004881711" evidence="1">
        <location>
            <begin position="22"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM30110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="128" mass="13879" checksum="72D5E569E4DFE8D4" modified="2014-04-16" version="1">MANLLGSILLLLTFIYTLCLAHSPNLREIHRSPNGTWVENIAVRPDGNLLVAVLSTAELWEIDPSIPSGPSSANLVHHFDGAEDADGITELSPDIYAVIASNSVWTVDLKHHRNAPSQFSSQNSPLTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q1B7</accession>
    <name>W6Q1B7_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein family SERF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S01g001825</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q1B7"/>
    <dbReference type="STRING" id="1365484.W6Q1B7"/>
    <dbReference type="OMA" id="NTMSGTE"/>
    <dbReference type="OrthoDB" id="18018at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007513">
        <property type="entry name" value="SERF-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04419">
        <property type="entry name" value="SERF-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Small EDRK-rich factor-like N-terminal" evidence="2">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM28014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="64" mass="6976" checksum="50FB73AA6ACB7260" modified="2014-04-16" version="1">MTRGNQRDNDRAKALKKAGNSKNKNTQTGSEFARAKEDAAAIMREKQRKADEKRAAEAAAGGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q1K5</accession>
    <name>W6Q1K5_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein transport protein SFT2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PROQFM164_S02g000349</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Nonessential protein required for the fusion of transport vesicles derived from the endocytic pathway with the Golgi complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Golgi apparatus membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the SFT2 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q1K5"/>
    <dbReference type="STRING" id="1365484.W6Q1K5"/>
    <dbReference type="OMA" id="PTHNEGP"/>
    <dbReference type="OrthoDB" id="660759at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007305">
        <property type="entry name" value="Vesicle_transpt_Got1/SFT2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011691">
        <property type="entry name" value="Vesicle_transpt_SFT2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23137:SF36">
        <property type="entry name" value="VESICLE TRANSPORT PROTEIN SFT2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23137">
        <property type="entry name" value="VESICLE TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04178">
        <property type="entry name" value="Got1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="84"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="115"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="149"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM30200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="218" mass="24195" checksum="6B61810151441212" modified="2014-04-16" version="1">MANNSFRDSVNSLGWSRRDPDLPVQTGASSNTPFLSRLQSYNPFGEGGYVQLPTHNEGPGAPLPAPTRREEEEGFFALSRWDRMLIFGACNLGAAICFMICFFLFPVLSLKPRKFAVLWSVGSVLFLLSWAVLMGPWTYAKHLVSGTRLPFTAAYFGSIALTLYFAIGRQNLFLTLIFSIFQLAALVWYLVSYFPMGSTGLQYVGRFGASRVTAWVSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q211</accession>
    <name>W6Q211_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">glycerol-3-phosphate dehydrogenase</fullName>
            <ecNumber evidence="4">1.1.5.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">Gpd2</name>
        <name evidence="16" type="ORF">PROQFM164_S02g000175</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">FM164</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.5.3" evidence="4"/>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q211"/>
    <dbReference type="STRING" id="1365484.W6Q211"/>
    <dbReference type="OMA" id="PHIVKPM"/>
    <dbReference type="OrthoDB" id="264015at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004368">
        <property type="term" value="F:glycerol-3-phosphate dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006072">
        <property type="term" value="P:glycerol-3-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.870:FF:000001">
        <property type="entry name" value="Glycerol-3-phosphate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.9.10:FF:000001">
        <property type="entry name" value="Glycerol-3-phosphate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.870">
        <property type="entry name" value="Alpha-glycerophosphate oxidase, cap domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031656">
        <property type="entry name" value="DAO_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038299">
        <property type="entry name" value="DAO_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000447">
        <property type="entry name" value="G3P_DH_FAD-dep"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11985">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11985:SF15">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16901">
        <property type="entry name" value="DAO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01001">
        <property type="entry name" value="FADG3PDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00978">
        <property type="entry name" value="FAD_G3PDH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="8" id="KW-0274">FAD</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="14">
        <location>
            <begin position="85"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-glycerophosphate oxidase C-terminal" evidence="15">
        <location>
            <begin position="502"/>
            <end position="629"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF16901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CDM30026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="701" mass="76711" checksum="3B09FC920D1CC55E" modified="2014-04-16" version="1">MAARHSRKFLRPLLYTSAAPAAGGGGAGVIYISYRPRNIPGLEAPAVPPPGYYKGKLVPPSFPSIKSRLEQIEDLKRSEEEEEYDLLVIGAGATGAGIALDAATRGLKVAVVERDDFSSGTSSKSTKLVHGGVRYLEKAVWELDYNQYALVKEALRERKYFLNTAPHLSSWLPIMVPVQKWWQAPYFWAGTKAYDFLAGSEGIETSYFLTKSKAIDAFPMLKRDNIIGAMVYYDGAHNDSRMNVSLAMTAALYGTTVVNHLEVTGLNKDASGRLCGARAKDIVAEKNGEVAKEFNIRAKGVINATGPFSDSIRKMDEPNVKEIVAPSAGVHIILPGYFSPSNMGLIDPSTSDGRVIFFLPWQGNTIAGTTDQPCEIEAQPQPTEKDINWILSEIRGYIAPDITVDRSDVLAAWSGIRPLVRDPKVKNSEALVRNHLVTVSQSGLLTCAGGKWTTYRQMAEEAVDEAVKSFKLKPRQLNSLPDISGVGGSGLVADGAVLDGSCQTHQVRLIGAHGYSKTLFINLIQHFGLETDVAKHLTESYGDRSWQVAALSSPTSERFPVRGCRISPMYPFVDGEIRYAVRHEYAQTAVDVIARRTRLAFLNAEAALESLPTVIDTMAEELKWTNARKDLEWKDSLTFLSSMGLPKSFMGLSRHDVQNGRVTQVDDAERATFSRKEPPADMIESDVRATIEPPAATPALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q277</accession>
    <name>W6Q277_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transcription initiation factor TFIID subunit 13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PROQFM164_S02g000245</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TAF13 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q277"/>
    <dbReference type="STRING" id="1365484.W6Q277"/>
    <dbReference type="OMA" id="PWPFNPQ"/>
    <dbReference type="OrthoDB" id="10266074at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07978">
        <property type="entry name" value="HFD_TAF13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003195">
        <property type="entry name" value="TFIID_TAF13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11380:SF5">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11380">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID/SUPT3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02269">
        <property type="entry name" value="TFIID-18kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="47"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="117"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="285"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="63"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="78"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="117"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="293"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM30096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="324" mass="35153" checksum="954B566F686FFEAE" modified="2014-04-16" version="1">MSAKRTGQAAKRVSFSLPPYASPLPLKPSHTGLSTLNTWTRTPICPFETTISAPPNAHLQAPSTFSSTSKTDSSNPTRNPSRQPSSKTLVSELSPNWGFDEQDTVLNCAGYGPKWTLSSPDTASTSTRKDKKESTTKPTMAEPRARTARHKGQMNFQNELRLLLLAYGDPSPHPSFPNEPLPETVRVLDEIVTDFVLELCHGAAQVAHHARRQKIKVEDFRFALRRDQNKLGRVQELLRMERELKEARKAFDQNDDQVAKEAGKKGAAAAAAAAAAGEDPVAAEAAAAATVTKKSKGKGKRGAATRRGSDATEESVSKKRKTIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q278</accession>
    <name>W6Q278_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">S-adenosylmethionine synthase</fullName>
            <ecNumber evidence="11">2.5.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">eth-1</name>
        <name evidence="16" type="ORF">PROQFM164_S02g000559</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the formation of S-adenosylmethionine from methionine and ATP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-methionine + ATP + H2O = S-adenosyl-L-methionine + phosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21080"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="2.5.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="11">Binds 1 potassium ion per subunit. The potassium ion interacts primarily with the substrate.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11">Binds 2 magnesium ions per subunit. The magnesium ions interact primarily with the substrate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 11">Amino-acid biosynthesis; S-adenosyl-L-methionine biosynthesis; S-adenosyl-L-methionine from L-methionine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the AdoMet synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.6" evidence="11"/>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q278"/>
    <dbReference type="STRING" id="1365484.W6Q278"/>
    <dbReference type="OMA" id="ASYMARY"/>
    <dbReference type="OrthoDB" id="5852090at2759"/>
    <dbReference type="UniPathway" id="UPA00315">
        <property type="reaction ID" value="UER00080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004478">
        <property type="term" value="F:methionine adenosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006555">
        <property type="term" value="P:methionine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006556">
        <property type="term" value="P:S-adenosylmethionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd18079">
        <property type="entry name" value="S-AdoMet_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.10:FF:000001">
        <property type="entry name" value="S-adenosylmethionine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.10:FF:000003">
        <property type="entry name" value="S-adenosylmethionine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.10:FF:000004">
        <property type="entry name" value="S-adenosylmethionine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00086">
        <property type="entry name" value="S_AdoMet_synth1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022631">
        <property type="entry name" value="ADOMET_SYNTHASE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022630">
        <property type="entry name" value="S-AdoMet_synt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022629">
        <property type="entry name" value="S-AdoMet_synt_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022628">
        <property type="entry name" value="S-AdoMet_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002133">
        <property type="entry name" value="S-AdoMet_synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022636">
        <property type="entry name" value="S-AdoMet_synthetase_sfam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01034">
        <property type="entry name" value="metK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11964">
        <property type="entry name" value="S-ADENOSYLMETHIONINE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02773">
        <property type="entry name" value="S-AdoMet_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02772">
        <property type="entry name" value="S-AdoMet_synt_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00438">
        <property type="entry name" value="S-AdoMet_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000497">
        <property type="entry name" value="MAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55973">
        <property type="entry name" value="S-adenosylmethionine synthetase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00376">
        <property type="entry name" value="ADOMET_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00377">
        <property type="entry name" value="ADOMET_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 11" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="9 11" id="KW-0630">Potassium</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="S-adenosylmethionine synthetase N-terminal" evidence="13">
        <location>
            <begin position="10"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="S-adenosylmethionine synthetase central" evidence="14">
        <location>
            <begin position="122"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="S-adenosylmethionine synthetase C-terminal" evidence="15">
        <location>
            <begin position="244"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CDM30410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="387" mass="42069" checksum="D3538D0B98CB98FE" modified="2014-04-16" version="1">MGSVANSGTFLFTSESVGEGHPDKIADQVSDAILDACLAEDPLSKVACETATKTGMIMVFGEITTKAHLDYQKIIRGAIKDIGYDASEKGFDYKTCNVLVAIEQQSPDIAQGLHYEEALEKLGAGDQGIMFGYATDETPELLPLTVLLAHKLNAAMKAARQDGSIPWLLPDTKTQVTIEYAHDNGAVKPLRVDTVVVSAQHTDDVSTEELRATIKEKIVQKVIPAELLDDRTVYHIQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYSKVDRSAAYVARWIAKSLVNAKLARRALVQLSYAIGVAEPLSIFVETYGTSSKTSDELVQIIRDNFDLRPGVIVKDLDLAKPIYYQTAKNGHFTNQEFSWESPRTLKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q2I5</accession>
    <name>W6Q2I5_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dynein heavy chain, cytoplasmic</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Dynein heavy chain, cytosolic</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">nudA</name>
        <name evidence="17" type="ORF">PROQFM164_S02g000888</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">FM164</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Consists of at least two heavy chains and a number of intermediate and light chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynein heavy chain family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1365484.W6Q2I5"/>
    <dbReference type="OMA" id="NERQMTR"/>
    <dbReference type="OrthoDB" id="447173at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008569">
        <property type="term" value="F:minus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007097">
        <property type="term" value="P:nuclear migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072384">
        <property type="term" value="P:organelle transport along microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.20:FF:000002">
        <property type="entry name" value="Cytoplasmic dynein 1 heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000122">
        <property type="entry name" value="Cytoplasmic dynein 1 heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.2620:FF:000001">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.100:FF:000002">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.30:FF:000001">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.180.20:FF:000002">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000071">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000517">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.720:FF:000003">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.130:FF:000007">
        <property type="entry name" value="Dynein heavy chain, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.1220:FF:000004">
        <property type="entry name" value="Dynein heavy chain, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000075">
        <property type="entry name" value="Dynein heavy chain, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000829">
        <property type="entry name" value="Dynein heavy chain, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.1220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.100">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.180.20">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.720">
        <property type="entry name" value="Region D6 of dynein motor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035699">
        <property type="entry name" value="AAA_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035706">
        <property type="entry name" value="AAA_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041658">
        <property type="entry name" value="AAA_lid_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042219">
        <property type="entry name" value="AAA_lid_11_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054354">
        <property type="entry name" value="DYNC2H1-like_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042222">
        <property type="entry name" value="Dynein_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043157">
        <property type="entry name" value="Dynein_AAA1S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041466">
        <property type="entry name" value="Dynein_AAA5_ext"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024743">
        <property type="entry name" value="Dynein_HC_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024317">
        <property type="entry name" value="Dynein_heavy_chain_D4_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004273">
        <property type="entry name" value="Dynein_heavy_D6_P-loop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013602">
        <property type="entry name" value="Dynein_heavy_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013594">
        <property type="entry name" value="Dynein_heavy_tail"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042228">
        <property type="entry name" value="Dynein_linker_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46532:SF4">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46532">
        <property type="entry name" value="MALE FERTILITY FACTOR KL5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12774">
        <property type="entry name" value="AAA_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12775">
        <property type="entry name" value="AAA_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12780">
        <property type="entry name" value="AAA_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12781">
        <property type="entry name" value="AAA_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18198">
        <property type="entry name" value="AAA_lid_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08385">
        <property type="entry name" value="DHC_N1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08393">
        <property type="entry name" value="DHC_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22597">
        <property type="entry name" value="DYN_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17852">
        <property type="entry name" value="Dynein_AAA_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03028">
        <property type="entry name" value="Dynein_heavy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12777">
        <property type="entry name" value="MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11 15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-0243">Dynein</keyword>
    <keyword evidence="6" id="KW-0493">Microtubule</keyword>
    <keyword evidence="12" id="KW-0505">Motor protein</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="16">
        <location>
            <begin position="1930"/>
            <end position="2068"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="16">
        <location>
            <begin position="2587"/>
            <end position="2737"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="16">
        <location>
            <begin position="2929"/>
            <end position="3095"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="1630"/>
            <end position="1657"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="3417"/>
            <end position="3458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00033439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CDM30738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="4342" mass="492947" checksum="38DF2EF2FE5793DD" modified="2014-04-16" version="1">[encoded data, 4342 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q2R0</accession>
    <name>W6Q2R0_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cyclase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S01g002315</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Cyclase 1 superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q2R0"/>
    <dbReference type="STRING" id="1365484.W6Q2R0"/>
    <dbReference type="OMA" id="TGWWTRF"/>
    <dbReference type="OrthoDB" id="5396at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004061">
        <property type="term" value="F:arylformamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:L-tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.50">
        <property type="entry name" value="Putative cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007325">
        <property type="entry name" value="KFase/CYL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037175">
        <property type="entry name" value="KFase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34861">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34861:SF10">
        <property type="entry name" value="CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04199">
        <property type="entry name" value="Cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102198">
        <property type="entry name" value="Putative cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM28504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="343" mass="38347" checksum="C97F81A5D68CDF72" modified="2014-04-16" version="1">MSSSTQVANKLPWDPNSTKFPSRKDLPKLPDAPDGAAWVWGNDDEVGRLNLLTPQRVKASAAEIDTGEMVRLDLPLTVPEKPAFDREILQHNIKTLVDGIAYDDTYIMNTQSGTQWDGFRHFAHIDSKCFYNGTKSSDFVGDTVNLRCSIHHWAMHGIAGRGILLDYYHYAKTHNKPYDPYTTHSITLSELQACAISQGLDLRPKSEGGDIRIGDILLVRSGFVERYYELNPEQRYAAATRSHDDLCFAGLSRESAIRDWLHDCYFAAVAGDSPTFESWPVPEHDYLHQSLLALWGCPIGEMWDLELLAEKCRARGKWSFFMTSAPANMPGGVGSHANATAIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q3H9</accession>
    <name>W6Q3H9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S02g001020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q3H9"/>
    <dbReference type="OMA" id="NCCEISG"/>
    <dbReference type="OrthoDB" id="3538998at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004879570" evidence="1">
        <location>
            <begin position="23"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM30870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="346" mass="36747" checksum="4FEFC4D4FAEAE411" modified="2014-04-16" version="1">MLSKFFLASAATVAAFAGLANAQTNITEKDCASSSEYSKCNRDVADKWSSCLRGCNGNGNCVVDCGCDSHQKYINCMAESCWNQVYSCKYQLFVQQYFAICPSAKEPIPFWPPPDNAPNRCSCDLGKVTQTTLSSRNQQIKCMRNVTDNISADIGSIPDLSKLNNGLDIANRASDCACCGASASISASWDICPHTEPTLAGADMWGVFFPSDLPNLYTSLPNWAWSSCDSTLKDTTCKDLGFTDTDKFYKPGDFPSNGTSTLYEVGGTVTAPPSGTVLTWSQVSTTYTVTATGYDLKAVSSQSEYRATATGTDQAFATQTADSGAGAVRNGGVGAVVAGVFAVVML</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q430</accession>
    <name>W6Q430_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Transcription initiation factor IIA subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">toa2</name>
        <name evidence="12" type="ORF">PROQFM164_S02g001255</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation. TFIIA in a complex with TBP mediates transcriptional activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">TFIIA is a heterodimer composed of the large TOA1 and the small TOA2 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TFIIA subunit 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q430"/>
    <dbReference type="STRING" id="1365484.W6Q430"/>
    <dbReference type="OMA" id="QYYELYR"/>
    <dbReference type="OrthoDB" id="586585at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005672">
        <property type="term" value="C:transcription factor TFIIA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10014">
        <property type="entry name" value="TFIIA_gamma_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10145">
        <property type="entry name" value="TFIIA_gamma_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.190:FF:000001">
        <property type="entry name" value="Transcription initiation factor IIA subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.18.10:FF:000003">
        <property type="entry name" value="Transcription initiation factor IIA subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.18.10">
        <property type="entry name" value="Transcription factor IIA (TFIIA), beta-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.190">
        <property type="entry name" value="Transcription factor IIA gamma subunit, alpha-helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009083">
        <property type="entry name" value="TFIIA_a-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009088">
        <property type="entry name" value="TFIIA_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003194">
        <property type="entry name" value="TFIIA_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015871">
        <property type="entry name" value="TFIIA_gsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015872">
        <property type="entry name" value="TFIIA_gsu_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10966">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02751">
        <property type="entry name" value="TFIIA_gamma_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02268">
        <property type="entry name" value="TFIIA_gamma_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009415">
        <property type="entry name" value="Hum_TFIIA_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47396">
        <property type="entry name" value="Transcription factor IIA (TFIIA), alpha-helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50784">
        <property type="entry name" value="Transcription factor IIA (TFIIA), beta-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="6 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription initiation factor IIA gamma subunit N-terminal" evidence="10">
        <location>
            <begin position="6"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="Transcription initiation factor IIA gamma subunit C-terminal" evidence="11">
        <location>
            <begin position="63"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00063181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR009415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDM31105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="111" mass="12524" checksum="036521832F97058E" modified="2014-04-16" version="1">MASVAYYELYRGSSLGLSLTDTLDDLINEGRIEPQLAMKILGTFDKIVTEVLADKVRARLTFKGHLDTYRFCDEVWTFLIKDVSFKLDNQTTVSADKVKIVSCNSKRPGEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q4B4</accession>
    <name>W6Q4B4_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Class E vacuolar protein-sorting machinery protein HSE1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Class E vacuolar protein-sorting machinery protein hse1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PROQFM164_S02g001335</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the ESCRT-0 complex which is the sorting receptor for ubiquitinated cargo proteins at the multivesicular body (MVB).</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the ESCRT-0 complex composed of HSE1 and VPS27.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the STAM family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q4B4"/>
    <dbReference type="STRING" id="1365484.W6Q4B4"/>
    <dbReference type="OMA" id="DWPGPDS"/>
    <dbReference type="OrthoDB" id="546434at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00155">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06224">
        <property type="entry name" value="REM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11883">
        <property type="entry name" value="SH3_Sdc25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000072">
        <property type="entry name" value="Unconventional Myosin IB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.870.10">
        <property type="entry name" value="Son of sevenless (SoS) protein Chain: S domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056685">
        <property type="entry name" value="DUF7783"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056686">
        <property type="entry name" value="DUF7784"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000651">
        <property type="entry name" value="Ras-like_Gua-exchang_fac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019804">
        <property type="entry name" value="Ras_G-nucl-exch_fac_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057827">
        <property type="entry name" value="WW_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF368">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25006">
        <property type="entry name" value="DUF7783"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25008">
        <property type="entry name" value="DUF7784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00618">
        <property type="entry name" value="RasGEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23518">
        <property type="entry name" value="WW_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00229">
        <property type="entry name" value="RasGEFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00720">
        <property type="entry name" value="RASGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50212">
        <property type="entry name" value="RASGEF_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0967">Endosome</keyword>
    <keyword evidence="8 10" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="13">
        <location>
            <begin position="73"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="N-terminal Ras-GEF" evidence="15">
        <location>
            <begin position="796"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GEF" evidence="14">
        <location>
            <begin position="965"/>
            <end position="1201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="153"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="229"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="694"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="154"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="325"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="700"/>
            <end position="716"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CDM31185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="1218" mass="136449" checksum="EA6E0E61C310CA70" modified="2014-04-16" version="1">MFGIRAADLAVDTTALAKSGSVATAFEYTDEQVTTPTALSRYRGRGNSVSRDFNHINHSPSKMASGYAVSPEPPALFVRAMYDYDADDHTSLSFRRGDIIQVLNQLETGWWDGVIDDVRGWFPSNYCTPLTEADDFTNQFAHTHLETELGADSGLEDEYGDGHDEDEVHSDDNARDPQPILPMEGVAAPKEQEEAAFWIPQATPDGRLFYFNTLTGYSTMELPFENPTATIEPGPRDRNNFYVPDQTRPPPEMMARGFERDEDEYDGSASEAEGESLMLGSHGSISRRRQSVMDGISPATSMDSLYAPGSKDFKMPHPPNKRPQKSYSLGGNSTSTSMTESYSRPSISYPPQHFVDDGFAPPITWPLLVDNMRHAVESYRQTLFKGERAEYVRKAEDISDHLRMLLAAGSDTTDNHSGNPSIISTNKALYPYFRDMMSKFSKLVLSSHIAAADWPGADSANKCLQEADGVMQGVYGYVEVAQQQRGDVIHRIVPGFVSGSSSGGSWQNNGVSLHTSGPTSFLVPDGDSRSEPSVSLDTAFLDSIDILRRSFVGSIRRLEERLVVNRKIVTAQEHADIADAISAAAIKVIEQFRPWISSVESMNLAPLGTSFQNPQLVDFSLQKQRAYDAIGDFVLSCQAVSAPLADEWAELRGNSLDDRVNAVRGIARQLENYVSQIGFPLSLLLEQIPTEPVSSLRRGSRQESDDESFKKMHSRGESMAKIAESIGIPSSYAPEKEGGTDKVRRNMDKAQRFFGQAPPTAITREPIREPVREPEETPWFLKMAHEGEVFYDNKGDLPILKCGTLAGLVEHLTRHDKLDASFNNTFLLTYRSFTTATELFELLVQRFNVQPPFGLNQDDMQMWIDRKQKPIRFRVVNILKSWFDHFWMEPNDELHMDLLRRVHTFTSDSIATTKTPGTPTLLAVIEQRLRGQDTTVKRLVPTQSTAAPTPIIPKNMKKLKFLDIDPTEFARQLTIIESRLYSKIRPTECLNKTWQKKVGPDEPEPSPNVKALILHSNQLTNWVAEMILAQGDVKKRVVVIKHFVNVADKCRNLNNYSTLTSIISALGTAPIHRLGRTWGQVSGRTSAVLEQMRRLMASTKNFGEYRETLHLANPPCIPFFGVYLTDLTFIEDGIPSLTPSELINFNKRAKTAEVIRDIQQYQNVPYLLQPVGELQDYILSNLQGAGDVHDMYERSLEIEPREREDEKIARLLSESGFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q4S1</accession>
    <name>W6Q4S1_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Low-affinity glucose transporter HXT1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">HXT1</name>
        <name evidence="11" type="ORF">PROQFM164_S02g001799</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q4S1"/>
    <dbReference type="STRING" id="1365484.W6Q4S1"/>
    <dbReference type="OMA" id="INNMACP"/>
    <dbReference type="OrthoDB" id="2241241at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17356">
        <property type="entry name" value="MFS_HXT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000044">
        <property type="entry name" value="Hexose transporter Hxt3p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF92">
        <property type="entry name" value="LOW AFFINITY GLUCOSE TRANSPORTER MSTE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="222"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="312"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="346"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="377"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="408"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="446"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="477"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="55"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="529"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="540"/>
            <end position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDM31648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="564" mass="62303" checksum="4A3138585C88A3B7" modified="2014-04-16" version="1">MGVSTFMDKIKHGKAESQVSSQASPARADSTTAEKDNLTLDDSPVKYLTWRSFILGLCVSMGGFIFGYSTGQISGFTTMIDFKQRFAEYNAATGEYAFSNVRNGLIVGLLSIGTMIGALVAAPIADRIGRKYSISFWALVHIVGIIVQIATIDKWYQIALGRWVAGLGVGALSSVVPMYQSESAPRQVRGAMVSAFQLFVAFGIFISYIVNFGTETLKSDASWRITMGIGFAWPLILAIGTLFLPESPRYAYGHGRVEEARDVMCKLYGVPHNHRVVAQEMADMKLKHEEELAHGKAHWQEVFTGPRMMHRILLGVGLQSLQQLTGANFIFYYGTSIFQGIGLSNSYVTSIILGAVNFGMTLPGLYIVEHYGRRKCLMYGAAWMFVCFMIWASVGHEILVQTPSSHPAGVAMIVFTCFFIVGFATTWGPIVWAICGEMYPFKYRAVCMGIATAANWTWNFLISFFTPFISNTIDFRYGYVFAACCFLAVIVVFLFVNETQGRTLEEVDTMYILHVKPWKSAGWVPPEGIVADLHGPSTEAPKDGEAGTSEHQHHDGEPQEVAEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q5I7</accession>
    <name>W6Q5I7_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Protein mmf2, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">mmf2</name>
        <name evidence="1" type="ORF">PROQFM164_S01g003286</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q5I7"/>
    <dbReference type="STRING" id="1365484.W6Q5I7"/>
    <dbReference type="OMA" id="MNEVYID"/>
    <dbReference type="OrthoDB" id="309640at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019239">
        <property type="term" value="F:deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00448">
        <property type="entry name" value="YjgF_YER057c_UK114_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.40:FF:000004">
        <property type="entry name" value="Translation initiation inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="entry name" value="RutC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
        <property type="entry name" value="2-IMINOBUTANOATE/2-IMINOPROPANOATE DEAMINASE RIDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803:SF12">
        <property type="entry name" value="TRANSLATION INITIATION INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="YjgF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM29474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="116" mass="12542" checksum="6FACB94CF2646A01" modified="2014-04-16" version="1">MSRQLISSEKFPTKPHNCPAVKVPGLVFCAGQTATGEIKQATRTVLQNLKEVLELSGSSLEQVVKFNVYLADMKDFAGMNEAYIDFLPQPMPARSCLQAVAPGNGTVIEIECIAQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q5P9</accession>
    <name>W6Q5P9_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glutathione S-transferase kappa</fullName>
            <ecNumber evidence="4">2.5.1.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PROQFM164_S02g001801</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the GST superfamily. Kappa family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.18" evidence="4"/>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q5P9"/>
    <dbReference type="STRING" id="1365484.W6Q5P9"/>
    <dbReference type="OMA" id="PFWGFDR"/>
    <dbReference type="OrthoDB" id="4664297at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004602">
        <property type="term" value="F:glutathione peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000096">
        <property type="entry name" value="Glutathione S-transferase kappa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001853">
        <property type="entry name" value="DSBA-like_thioredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051924">
        <property type="entry name" value="GST_Kappa/NadH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014440">
        <property type="entry name" value="HCCAis_GSTk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42943">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE KAPPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42943:SF13">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE KAPPA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01323">
        <property type="entry name" value="DSBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006386">
        <property type="entry name" value="HCCAis_GSTk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DSBA-like thioredoxin" evidence="6">
        <location>
            <begin position="5"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00047960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR006386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR006386-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM31650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="223" mass="25579" checksum="C25D67A398E7E356" modified="2014-04-16" version="1">MSGKIDAYIDCVSPYSYYATLYLRRNRKVLESHGVEVEFHPGFLGGINVGSGNKPPWSLPAKATYSKFDSERACKYFGVPQIQTPEFFPILSILPQRCMIYIKNHFPREKYETTFLSLWEWMYYKGIDISKPENLTELLQSNGYSDSEVREILAAASSPEIKQALTANTQIALDKGAYGAPWFWVRNSEGKEEPFFGSDRFAFMWMYLGLPFQDIAIAEKSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q5X3</accession>
    <name>W6Q5X3_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S02g002244</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q5X3"/>
    <dbReference type="OMA" id="APNIPFC"/>
    <dbReference type="OrthoDB" id="4367311at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012361914" evidence="1">
        <location>
            <begin position="16"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM32093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="307" mass="30676" checksum="ED8C40195AFF60B4" modified="2014-04-16" version="1">MKSFAFALLASAAMALPANIPSGTIGSLPSGVPSSLPSGVIPSGMPLPMTSMIPSGSDVAATPSFSTLPDPTGAGQVLSILNQAGTSKIEMMAESELESLMSKLPLSALEKPVGQVIQTAESVDKLDTNTGSGLTQITALLDNGNAALIELTQEVVDLLSSLGLHKVGSLLGSIVGGLESITGNVKRDDPLQNVLSITDVNGLAGGKNLLVQVEPTVVGLLSGLDLSTIEGPIGNVVAVAPSVSELKSKVPEIPGANFIAVNAEDKVSVLLIKVDGAVQGLLSTLGLGSVGTTVGSIVSSAKGGLVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q637</accession>
    <name>W6Q637_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g003537</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q637"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM29724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="120" mass="13717" checksum="11B799F527CC9881" modified="2014-04-16" version="1">MPISDRPTAQATAIIRYTHRPATIQRQPRFSPRPDSYDSKTATQTFYGATKQKSSLRKTNKPKSTKRKSSLNKPKSTKRKSSLRKTNKQKTTRRKSSLREPNKPKTTKQTSTLTRPALNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q6D1</accession>
    <name>W6Q6D1_PENRF</name>
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        <submittedName>
            <fullName evidence="5">Homeodomain-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PROQFM164_S02g002036</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="SANT_TRF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052450">
        <property type="entry name" value="TRBD-Containing_Protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46734:SF1">
        <property type="entry name" value="TELOMERIC REPEAT-BINDING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46734">
        <property type="entry name" value="TELOMERIC REPEAT-BINDING FACTOR 1 TERF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13921">
        <property type="entry name" value="Myb_DNA-bind_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0371">Homeobox</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH myb-type" evidence="4">
        <location>
            <begin position="301"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="3">
        <location>
            <begin position="301"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="32"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="123"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="242"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="384"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="533"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="53"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="244"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="298"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="384"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="401"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="423"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="545"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="587"/>
            <end position="598"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDM31885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="675" mass="72484" checksum="60E8227F7318C718" modified="2014-04-16" version="1">MESASALRPLDESILRELPQLSLRIAPLREPVSSRTLSVPSPLEPNASGTREPNNIPNSNSNSGKIPANAKAGLPTVTEFLNAARIRKTELSADSQSNVERPPRPILPAFVNLRALEKFPFSSSFDDDALQGPRKRRRRDPQADSFSEHLQLPIPQAQKEQRPPPFGPFAILNGLNEPPPNAALLPPIEAGSNISQLLTKPSRGGAAVDPGTLVAAHVAISDGQSAAERRDTRLEDILRMSLNVDEDDDPNDNDENVESTNPMDPDEIALAVRKAEDPKNTKALPLHSGQDVPISPKTRGRSRKNVRKWTEEETATLLRGVVKCGIGNWTAILAQPELEFNQRTASNLKDRFRVLCPWAYRTSDPNEAAKQLHDTLANTLLKAKGEGSDETPGKPHLSHIMPSSQGSESISGAEGQAPNPQKPSTSSTVSSTPDTDPGSSSIPQSQSPSSGNSTPAPASKSQTTLASLGIPANVVKSKRRSRRPFTAVEDEALLKGYAVHGFQWTLIQQDSRLNLSHRKATDLRDRFRTKFPHAYRDGGSVNGKAFTNPNQGQGQDSAAGASTPRPHPVNTEQSPSKAYAMTPTPTPNSTTASRNSASRSRHAATPSQSSLGQIDPALLPPPPQSFSEHSMYLPPAAAGALSFSLDDGPGAGAASTVETPWEDNTLAPMIWDELT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q775</accession>
    <name>W6Q775_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Zn(2)-C6 fungal-type DNA-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PROQFM164_S02g002366</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q775"/>
    <dbReference type="STRING" id="1365484.W6Q775"/>
    <dbReference type="OMA" id="HIFAFNW"/>
    <dbReference type="OrthoDB" id="2264294at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001080">
        <property type="term" value="P:nitrogen catabolite activation of transcription from RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050797">
        <property type="entry name" value="Carb_Metab_Trans_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668:SF4">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN DAL81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="43"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="8">
        <location>
            <begin position="299"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="656"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="24"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM32215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="676" mass="74889" checksum="7D794407F3964E5B" modified="2014-04-16" version="1">MATVITLQPGYSQTHSPDLRRKTGSTPVLSPSPISINSTLPRARNGASCDACLRRKSRCAMNEMVNKCYSCDFHRQECTFSHTHEGPSKKRKLDGQEPAEGIKRPSMQHCIPETESHLAVNMIRPGFFNQSTQYIGMTTELEPTLLDYLPLDEYDECTVANSRVRRCADDGTFMRVVDTVPDSHAVSLDAIESMVAPYGSTLIEKFFEHVHPSFPILIEEVFRQSYRERRGLSPLLLAAVYVLTLKFVDVGVTSQTARKPDAARLEASALKLLMDSLQFPSVSTIQAGLLLTQKSTLATASLNGQLVTAAFELGLHQDCTNWRMETWEKGLRKRLAWALYMQDKWSSLVHGRPSHIFAFNWTVKHLVEQDFSDAFASGTDSSHDETAVGHGPLLFCHMVALTTILSDILDRFYTLHAIEEFSAAGNQRTRMILEKAKPAQIRLKDWFSSLPASLKMETSTGELVETITDEHARNGALHLAYFATEITLHRCIVRSLLAEGTDQYLAHICRSAAKTRLISAMDFVNRLRPAHLRSFWPASARTNFSLIGSFGMLLRITAPTNEEADFYRVRLCEYRWTLGVSHKNAEFMGFALQSLDNATALHKHVPAKPGIAELMASSGKNAPPRMPPTTLSSYDDAMMEAAGTAASSSVMSGLASPATSISDMEDGEGEASMAPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q7G4</accession>
    <name>W6Q7G4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Helix-loop-helix DNA-binding</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PROQFM164_S02g000348</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
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                <person name="Giraud T."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
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        <location>
            <begin position="264"/>
            <end position="367"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
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        <location>
            <begin position="144"/>
            <end position="227"/>
        </location>
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            <begin position="242"/>
            <end position="271"/>
        </location>
    </feature>
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            <end position="475"/>
        </location>
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            <begin position="170"/>
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        </location>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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</entry>
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        </lineage>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
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                <person name="Debuchy R."/>
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                <person name="Silar P."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1">FM164</strain>
        </source>
    </reference>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="42" mass="4700" checksum="F7D3F966A15B6E4E" modified="2014-04-16" version="1">MMRAGIDSASILLLLLAVLVVILFFANIPTAKTIVRNDHREY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q7Q4</accession>
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        <submittedName>
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        </submittedName>
    </protein>
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    <organism evidence="2 3">
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
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                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
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        <location>
            <begin position="113"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM32041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="257" mass="30001" checksum="13174CD4FE1823A5" modified="2014-04-16" version="1">MHHHMSRQSKARRNIIPQCHLTETQQNTDCYDHHHLCHVQQPTPCSRDHHLHLNNTDIDTVKHRAYHLRQAPSTKETIHCYFCPNFQGQGPRLRMNNVDSDPLVQHHEICHNRHKSQHIHLQSRSRSSESSEDEEHRYHTEHYHTQGIQSNERQHHPPTVKHVHSKSSNSMFDHGHHHAATPAQSTCAHATVFNSHDDGCGSNMKAVRFEEDDRPETHHSDCPIHGTPSHGEDRWVWGPPLPVVAPRREKTYYAERY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q7U7</accession>
    <name>W6Q7U7_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4219 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S02g002924</name>
    </gene>
    <organism evidence="2 3">
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        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
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            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
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                <person name="Giraud T."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="DUF4219"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13961">
        <property type="entry name" value="DUF4219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4219" evidence="1">
        <location>
            <begin position="19"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM32773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="136" mass="15438" checksum="510D9870CE739B9D" modified="2014-04-16" version="1">MSALVHDSPDRAVTAIEPLTGSDNFATWKRLMTSYLKARQVWDVVSGDLQRPDCLFKYAKPITADIHPLVEPHLNGTVRQRTIEARLEVEVQAFERHREWSRREAEAYQPRTLSAWSSLNNLPGSLCFAALCLACK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q7W5</accession>
    <name>W6Q7W5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S02g002949</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q7W5"/>
    <dbReference type="OrthoDB" id="8904098at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM32798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="117" mass="12555" checksum="0AF58C802C942D77" modified="2014-04-16" version="1">MRVWLAATIGMAARFSYYGTQTLFQNYLQNRPNDLVPGAMGLGKSRATMVNLAFTVLVNILPLPTSILVDGCLGRYRALQIFTGIYAKGSVILFATSLPSEILSGVASPGFPKGPDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q8S0</accession>
    <name>W6Q8S0_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S02g002537</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q8S0"/>
    <dbReference type="STRING" id="1365484.W6Q8S0"/>
    <dbReference type="OMA" id="NHGSRKV"/>
    <dbReference type="OrthoDB" id="2152248at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47381">
        <property type="entry name" value="ALPHA/BETA-HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47381:SF3">
        <property type="entry name" value="ALPHA_BETA-HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM32386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="363" mass="39532" checksum="E58493EC0FCD6063" modified="2014-04-16" version="1">MTDPLKSVSDVGSVAAAISERVYTIAGISVTVFGLEELRKEASEVACLWLLHPRLATQERMTSIANSAITDWNTRNQDTPTAKGLIAVSFDQRNHGTRLVDPLGNESWKKGNPRHAQDMFSIFQGTARDTSVLMDYLPSYIFPSGEHKITQNLVLGVSLGGHAAWSCLLHEPRVTAGVVIIGCPDYINLMADRARLSKLPSWTKSDPPGADVLGSEALPTSFLETVSRYDPASMMLKHVDCGPLTGPLREGPLPQPSESEQKVLRPILTHALAGKRILNLSGAKDKLVPYHRGELFLNWLKQSISSDGWFGDGGVHFEDIIDESAAHEVTAKMADEAVRFISETLAVGPDQGGRRGSVRESKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q8U2</accession>
    <name>W6Q8U2_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S02g002936</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q8U2"/>
    <dbReference type="OMA" id="ESPESHC"/>
    <dbReference type="OrthoDB" id="4347333at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM32785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="420" mass="47056" checksum="937D2F422B947F2C" modified="2014-04-16" version="1">MHVKPSNMSLQIVAANSTRGSQQASIKKCVLQRLLSSWWLTETEKPTNTSSIPGNLLYDYSPVYIVDQQIRQCLSMDIRPYASARATASCGLFILVLTIRTLNLWELTRVALITLHYRQCSTQSHGLHTIPSPVASNNAACPRWKIANQDSHFHAKGHPSSTVKYTVASGLFRQIEDKTKVSADERAPSRLPPSSPPPSHYCGALNLWHRDTFIHHGSAMFITSAFVTRVYCLNKLSCAPQRGFFEASADCDELECDVAWLVTALKRVENTLISVTRVECHANKYLVCSSSPIQLRLHALSPFHITTIDNESPESHCSICLYDTTPELRLAYTTTRITPVAKRITFQIPSSGVGYWYRMRDPRCLRMTFDERTSADNQAVSTSPPARGRRRKVFSFLAYNLTLDISGTNREDKIGAQASQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q9B0</accession>
    <name>W6Q9B0_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Coatomer subunit zeta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">ret3</name>
        <name evidence="14" type="ORF">PROQFM164_S01g000151</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 12">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 12">Golgi apparatus membrane</location>
            <topology evidence="1 12">Peripheral membrane protein</topology>
            <orientation evidence="1 12">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Cytoplasmic vesicle</location>
            <location evidence="12">COPI-coated vesicle membrane</location>
            <topology evidence="12">Peripheral membrane protein</topology>
            <orientation evidence="12">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the adaptor complexes small subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q9B0"/>
    <dbReference type="STRING" id="1365484.W6Q9B0"/>
    <dbReference type="OMA" id="NELMLHS"/>
    <dbReference type="OrthoDB" id="10249988at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000013">
        <property type="entry name" value="Coatomer subunit zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039652">
        <property type="entry name" value="Coatomer_zeta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11043:SF0">
        <property type="entry name" value="COATOMER SUBUNIT ZETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11043">
        <property type="entry name" value="ZETA-COAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 12" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6 12" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8 12" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AP complex mu/sigma subunit" evidence="13">
        <location>
            <begin position="51"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00045555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU366053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDM26342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="201" mass="22067" checksum="C8D3F8E0803EB6E0" modified="2014-04-16" version="1">MPGSLSLFSVNAVLVMSADDGSRIYAKYFSAPHPPAGAAPNSTDYPGANPYPTVKEQRSFEKGLLEKTNKSASDVILYDNRIVVFKMESDVMLYVVGSADENEVLLYNVVLSLRDALGILFKGATDKRTIVENYDLLSLTIDETIDDGIILETDPVMIASRVSRAPAADAPNMKNIDLTEQGLMNAWEFGKRRLAEGLRQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q9U9</accession>
    <name>W6Q9U9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S02g002907</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q9U9"/>
    <dbReference type="STRING" id="1365484.W6Q9U9"/>
    <dbReference type="OMA" id="DIPGCPH"/>
    <dbReference type="OrthoDB" id="3335358at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.170.20">
        <property type="entry name" value="Protein of unknown function DUF952"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009297">
        <property type="entry name" value="DUF952"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34129">
        <property type="entry name" value="BLR1139 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34129:SF1">
        <property type="entry name" value="DUF952 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06108">
        <property type="entry name" value="DUF952"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM32756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="136" mass="15599" checksum="4A0F2302DC7E7209" modified="2014-04-16" version="1">MKKMGDSAPLYVYKIVPSTNPVREPLPERLPVSHIDQSSGFIHLLTAPQVPIALKAIFESEPMVYVFRIPYNKVMQDIRWETADGALREALPEEDLCPHLYNKFNLGRDDVESIAVWINENGWEKVLSQTGTWLLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W6QAH2</accession>
    <name>W6QAH2_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Kinetochore Spc7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S03g000134</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1365484.W6QAH2"/>
    <dbReference type="OMA" id="WRMKLQE"/>
    <dbReference type="OrthoDB" id="5592879at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990758">
        <property type="term" value="P:mitotic sister chromatid biorientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034501">
        <property type="term" value="P:protein localization to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040850">
        <property type="entry name" value="Knl1_RWD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033338">
        <property type="entry name" value="Spc105/Spc7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013253">
        <property type="entry name" value="Spc7_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28260">
        <property type="entry name" value="SPINDLE POLE BODY COMPONENT SPC105"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28260:SF1">
        <property type="entry name" value="SPINDLE POLE BODY COMPONENT SPC105"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18210">
        <property type="entry name" value="Knl1_RWD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15402">
        <property type="entry name" value="MELT_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08317">
        <property type="entry name" value="Spc7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00787">
        <property type="entry name" value="Spc7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01315">
        <property type="entry name" value="Spc7_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Spc7 kinetochore protein" evidence="3">
        <location>
            <begin position="942"/>
            <end position="1278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="417"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="534"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="592"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="841"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="980"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1139"/>
            <end position="1191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="26"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="72"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="173"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="232"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="263"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="300"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="321"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="351"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="442"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="534"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="548"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="592"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="624"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="658"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="725"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="758"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="784"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="797"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="893"/>
            <end position="924"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM33410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="1490" mass="163648" checksum="0DABE010AFB2EAC0" modified="2014-04-16" version="1">MSTRPDSAALRPPRSRRSIAHVPRSRMTSSLDKENATTQIGAAQPFLNNTKPAMKDKKSRSKSLGPGGLDALQNSNGNRRQSTASFPLKSILKPTVPVSPVRTIPSFEETRRRTPARSKQQTHDGTMDGQGQTDQKKEGLLIDFETTPGPPTTDNDNDDTANPFDTFNATSAIREEMAATKERDEQERKDRERQNILEKRAARRKSMANRRVSFAPEATLHTWNVVEIPDDSTSSSAANSTRRASAAVSSQNQPAPASPTKDAPSSPAESEFEFSPVRTQDLNQIRGRPSSGDDDVQDLSSSPFSGSSVGSEDTGAQSLAGEDDDGDSSDSDDGFDAESTAMSMDDMTARSGMSVQSDATSSSSSSARLNEALRQAAQEAGTELDEGGEMSMEIVDQEITGAFQPWIKKGQRQSFDWGDISARHDEENLDPSKAATTQGSPESDDIDEDEDLSMDVTNAVGRILGKSPGRRQSTARRQSVAEESNYGDQTMEMTNVVGGIAQVDSPFNFSEIGNEDEGMTMEFTSAVGKILGNQPTYASNSDHMNFDQENESDDGMDMEMTGAIGGILQSGIEANDKVHAKMIMELETDSGQLASSPFQDNVRQSPAKSPLAYQIAAVASENGSPSSATMRPRPPRRSSTPGSSSRQRSPNTKPLTPPKQSTPQAKPTTPSKTPPSSNVTFRSASPKKLFQPELQQSADKRKSLRQSLFEHNIATGESTPLFKLQPRESRRSSGLGIDKEGLGSPRVAALLDKRPSLGDSTPQFVPQEQPRSGVRFEDPLQMQAEEERDREEEELREDGYIRGLQSDRDVTPSLKDLISNLSPKKTRIGNRKSLHVGAARGVLGKRPVELDLDEDEVENSPKRLRGHNVSPVKGVKLPTPMFREANIRRSILSPVRRAASSSPPKGSTTPSQQPRSSSQTSTTPLNHGIDALHIASDPQQPEEEEVTPTEEATVEIESIQLQDFLKMTNIHFMELTTTKRRHTTAPGSATKKLTRPSGESMPKPGSITFDDCVAAGFCTVPMLELYQHSCRELKSYISEGRQVIRSIEAETYAENPALFKEYITAPPDIRVIMDNQFRNVKTHARLLSKATWYEWRMKLLEGLKEGLIRHVEEMKADDDLLSEREELLNRNVPFLVEKHASLEEEATNLKQLVEEMENCDQDELRNTRSKLSEVDSEIAVKRRELEQLQKEVQAKGTFIEAGAEMRDEFLAQIQEAERVKEECRGWSAREINELKASVQRIQQQTGWSIVSAAIPSDDASKGPLLKMAYRDKLQLEFYPGAFASKKSGQDEGKNYPMELASQKNANISPIASLVLHSLQHYLATIQQSTVAPKQLLRFISSAWDRTVGLENEARMLEFCGVTRLTLSKPDVGSLSLRTRCTLLGNATVSTPGRKGIASKNNGAKRIDVDFTVRTRIDKANAENTIGSLDFDIDVLATKVYGFGPGSKSGLPDKELQSILGKGLSREKDGDVQLGNGLWCKAVRILTGSVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W6QC09</accession>
    <name>W6QC09_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HPP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S03g000957</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QC09"/>
    <dbReference type="STRING" id="1365484.W6QC09"/>
    <dbReference type="OMA" id="WRLSWYF"/>
    <dbReference type="OrthoDB" id="2016548at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007065">
        <property type="entry name" value="HPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058581">
        <property type="entry name" value="TM_HPP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33741">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN DDB_G0269096-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33741:SF5">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN DDB_G0269096-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04982">
        <property type="entry name" value="TM_HPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="HPP transmembrane region" evidence="2">
        <location>
            <begin position="29"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM34233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="212" mass="23363" checksum="88C880672E7B51F7" modified="2014-04-16" version="1">MISEKEFLARLPRFISHWLGYRENAPKPPPKYLVHFWSFIAAFCGLCVVQGIFNYSSYFIERGVPGIIASYGASAVLVYGAIESPLAQPRALIGGHFLSALVGICISKLFSLMHNEEKFDSLRWLAASLSSAVAIVVMQITETTHPPAGATALLPAVDEAVWALSWYYLPVVLLSSTMILMVALVVNNIQRRYPVFWISPPAPKPVLPQATN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>W6QC13</accession>
    <name>W6QC13_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">acetyl-CoA C-acyltransferase</fullName>
            <ecNumber evidence="6">2.3.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PROQFM164_S02g001840</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA</text>
            <dbReference type="Rhea" id="RHEA:21564"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
            <dbReference type="EC" id="2.3.1.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.16" evidence="6"/>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QC13"/>
    <dbReference type="STRING" id="1365484.W6QC13"/>
    <dbReference type="OMA" id="NASPMND"/>
    <dbReference type="OrthoDB" id="5404651at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003988">
        <property type="term" value="F:acetyl-CoA C-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010124">
        <property type="term" value="P:phenylacetate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050215">
        <property type="entry name" value="Thiolase-like_sf_Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020610">
        <property type="entry name" value="Thiolase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43853">
        <property type="entry name" value="3-KETOACYL-COA THIOLASE, PEROXISOMAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43853:SF12">
        <property type="entry name" value="ACETYL-COA C-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00099">
        <property type="entry name" value="THIOLASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase N-terminal" evidence="10">
        <location>
            <begin position="33"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase C-terminal" evidence="11">
        <location>
            <begin position="298"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="8">
        <location>
            <position position="118"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="375"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDM31689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="420" mass="44271" checksum="9B2CAA517D0328BC" modified="2014-04-16" version="1">MSSPQQRLSSVANQLAAPGSARQKLLAKNPDDVVITYLARTPLTKARKGGLKDTSVDDLLISLLTKTVREKSNLDPNLVEDVCVGNVLCPGSAYVARSAVLAAGYPVTAAASIANRFCSSGLLAVQNIANQITAGSIDVGVAVGAESMSKNADGGAPEMSERIAKHPIASQNSLPMGQTSENVANQFDITREQHDRFAANSFQKAERAQKAGWLDDEIVPVKTQIKDPKTGEVKDIVVDRDDGIRYGTTPESLGKVRAAFPQWAPSATTGGNASQITDGAAALVLMKRSRAQELGQPIVAKFCGATVSGLEPRIMGIGPSLAIPKILNKFNLSKDDIDIFEINEAFASMGVYCVNKLGLDESKVNPRGGAIAFGHPLGATGARQVVTALSELRRQDKRIAVTSMCVGTGMGMAGIFVSEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W6QCN5</accession>
    <name>W6QCN5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Thioredoxin-like fold</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PROQFM164_S01g001173</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Putative mitochondrial redox protein which could be involved in the reduction of small toxic molecules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FMP46 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QCN5"/>
    <dbReference type="OMA" id="IVDWNNG"/>
    <dbReference type="OrthoDB" id="59229at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012882">
        <property type="entry name" value="Fmp46"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28071">
        <property type="entry name" value="REDOX PROTEIN FMP46, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28071:SF1">
        <property type="entry name" value="REDOX PROTEIN FMP46, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07955">
        <property type="entry name" value="DUF1687"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="33"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="45"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM27362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="153" mass="16901" checksum="A411BF929F3BADC1" modified="2014-04-16" version="1">MFRFSKTLDPITLFHSPSIQASTRTLNILKQASATAGETATEDQASDHTNHSKQQRGEFELEVTTSPPTTDQLRSILDYISPVSGVGNPGEKVTYGVAELVKGARDAEDALKKFKEDNENFVRPITVDWVNGRAVIGDDKSEILRMVRQLPVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W6QDD9</accession>
    <name>W6QDD9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S03</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S03g000805</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QDD9"/>
    <dbReference type="STRING" id="1365484.W6QDD9"/>
    <dbReference type="OMA" id="HSIMSCL"/>
    <dbReference type="OrthoDB" id="4453902at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM34081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="287" mass="33644" checksum="460FE7B3EC12218D" modified="2014-04-16" version="1">MAETQDQPHFQRLGVQAFQVSLAPEHGEGLQFDPCFFRPHPDKLCEKYPIYIYHLEDDPRDIQFTTLNDYIQDALTEHSPEYAPIIARMEYEEDSDVPPERDPYMHAQDVEEAIESHIKAGRSGPHECFSLVNFRKKDQERWNPNQREDHPRVYEGFEDPKPWRVVNHYRYISRPLKPHSIMSCLAQIWPDGNQSLTTHELRAIVNMMLLRVNHKSFRRCHTHPILVLSYMGGHHGRIIQASYDGKGLILQYPQLWSFADIKTTPVELFVRYRLSEPVGAIRTLSLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W6QDH5</accession>
    <name>W6QDH5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cystinosin/ERS1p repeat</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PROQFM164_S03g000840</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-histidine(out) + L-arginine(in) = L-histidine(in) + L-arginine(out)</text>
            <dbReference type="Rhea" id="RHEA:71063"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the laat-1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QDH5"/>
    <dbReference type="STRING" id="1365484.W6QDH5"/>
    <dbReference type="OMA" id="NDRLEWI"/>
    <dbReference type="OrthoDB" id="8048523at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015174">
        <property type="term" value="F:basic amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034488">
        <property type="term" value="P:basic amino acid transmembrane export from vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.290:FF:000009">
        <property type="entry name" value="PQ loop repeat family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051415">
        <property type="entry name" value="LAAT-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201:SF34">
        <property type="entry name" value="LYSOSOMAL AMINO ACID TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201">
        <property type="entry name" value="SEVEN TRANSMEMBRANE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00679">
        <property type="entry name" value="CTNS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="31"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="297"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="148"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="408"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="162"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00050768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM34116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="440" mass="48538" checksum="E49FA4EB8FF044E6" modified="2014-04-16" version="1">MSPPLLQYLLSGTLPDHCEPTSPFLTAVSSHLHICIPTPLAAISSVLGTLSIVSWLFAQLPQIYKNYQVQSTSGLSIFFLVIWCLGDASNLVGALYTRQAGWQVVIASYYVFVDIALVFQFFWYTHYKPRQNDSYDDLSHSHDSARRNIIQGVPPPGHDSDNQTPAPVNMNNKHPEAKDGGFQAGSALDSTHVPTASYSNEKLSSSRRSVRLGSSMQSPPFALPRTMLMASLLCAVLANAAPTDKSDTFISEAPRETIVEIIGRVFSWMSTILYLGSRPPQLYKNYQRKSTEGLSPLLFMAAFCGNLFYSSSMLTNPNAWSDFSPYGGGGWADNHGNNRLEWIGRATPFFLGAFGVLGLDGFMGVQFLMYGDGPEHEDDESFISGDGDDPKRGRSRWRHVHGWMRGWIPSASPRRDSRESSVSQEGQALLGAERGRYGTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W6QDJ8</accession>
    <name>W6QDJ8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lipase, GDSL</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S03g000875</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QDJ8"/>
    <dbReference type="STRING" id="1365484.W6QDJ8"/>
    <dbReference type="OMA" id="GLNWVGH"/>
    <dbReference type="OrthoDB" id="1600564at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01846">
        <property type="entry name" value="fatty_acyltransferase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001087">
        <property type="entry name" value="GDSL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051058">
        <property type="entry name" value="GDSL_Est/Lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45648">
        <property type="entry name" value="GDSL LIPASE/ACYLHYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_4G14700)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45648:SF22">
        <property type="entry name" value="GDSL LIPASE_ACYLHYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_4G14700)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00657">
        <property type="entry name" value="Lipase_GDSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM34151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="295" mass="32578" checksum="367CEE74E654F532" modified="2014-04-16" version="1">MKNRDDIGPIASGGTVAVTPLQAQDAPTYLFTFGDSYTQTDFTVDGTQPSISNPMGNPILGTGTTSGGINWVGYLTTLYNVSPVLSYNFAVIGATIDNSIVDSKVKDVTSQVRDFELAYSKKPTSAPWSSDNAVFGFWIGINDIGRGHQNTQPNVLVPTLMAQYKCLIEKIYASGGRRFLFLNVPPTDRSPMITKQGPEAVKTHATWVRAYNSGLQSMISDFKSNHTDTTIVLYDTWSFMPKILDDPQTYGFPNATCFNKDGTSCIWWDHYHPGQNYHKLQAADMVQYLQPLGAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W6QDS9</accession>
    <name>W6QDS9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S03</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S03g000960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QDS9"/>
    <dbReference type="STRING" id="1365484.W6QDS9"/>
    <dbReference type="OrthoDB" id="5400577at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37535">
        <property type="entry name" value="FLUG DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37535:SF3">
        <property type="entry name" value="FLUG DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM34236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="191" mass="22113" checksum="870D4C2BFFA71A31" modified="2014-04-16" version="1">MTDPQYMLSRKDFFAKRDEIAKTKRRLQREKNGYIPRAPQTGGLNSGEGQEASKTKSLHHKTVKLWLNFTADPENGFEYYKTSLGCPAPSHDMIKQFIRWYTSSIQGRLNEDELPTVRTWIKNTLTADGIVIDQKKEKLNFTKQDFLITVSSLWQTDHQKFIPGLLKVFVLFALQLYLFTGARVGSFIQYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W6QDT4</accession>
    <name>W6QDT4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Epidermal growth factor-like domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PROQFM164_S02g002475</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM164</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QDT4"/>
    <dbReference type="STRING" id="1365484.W6QDT4"/>
    <dbReference type="OMA" id="TCSCICT"/>
    <dbReference type="OrthoDB" id="283575at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00053">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17178">
        <property type="entry name" value="SECRETORY GRANULE PROTEOGLYCAN CORE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17178:SF0">
        <property type="entry name" value="SERGLYCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="407"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="4">
        <location>
            <begin position="437"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="140"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="321"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="584"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="219"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="590"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="464"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDM32324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="702" mass="73994" checksum="72B1605276E122E5" modified="2014-04-16" version="1">MGLPPRSSSQPQPSALAQSHRPIDNTPASPTSTIDLTPRISIATEDLFRQSVASDMPQFPPTSLPAESDLSQDEPRHRTAGLVAPLNSRRPPRARRSSVSPIPEELAHPRFTKCSVASSRAIPSWGSGPAESEILGAYDIDSDDGQRSPGFQEDDTRLVRNASIGKRGKPTMRTILKSNPVSVVDMPAPTQEESAKGTTARSVGLGAAASQAPHIPSQLRKSSTTSSEPPKGLNLEKPPLSTKHESLSSNAQLEKELEAFGQLPNAAPTMSDKRPGGRKPPALNMHALRDAEARGSLSSLSDLIRRATKLASNLDHGRTASRANLAGDEAGFKGMGHRPRNSGSLSEMLASFPPPGLATPEARGSTASWPVFFGRSNLRNVEQLNSSDDDPNAPRRKKTCCGIPRKIFVLICVVIFIIVILAVLLPVFLVAVPRENASTPCAEKNPCENGGVSVSAGTQCSCICSNGYIGSQCTVLGDGSCTTALISDGSNATMGSALPVLFNESKEKFNITLDPVTIMALFNMNDVTCTTENALVAFSAVTTDTSKTRRSVNLVADSMPSVSKTDPTPVLAVRSEATMNGILYDDSESSKTATTTSAPTQTESATSASATKASSQTTAAAASTSTAISVPDKVVGFSRIAVLYILQKTGSLDTALSSEEDIEEYLADSYANATQPAMKVGAFAVDFEKLTITLPNSTVKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W6QDX3</accession>
    <name>W6QDX3_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial</fullName>
            <shortName evidence="7">Glu-AdT subunit A</shortName>
            <ecNumber evidence="7">6.3.5.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PROQFM164_S03g001650</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>L-glutamyl-tRNA(Gln) + L-glutamine + ATP + H2O = L-glutaminyl-tRNA(Gln) + L-glutamate + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17521"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="Rhea" id="RHEA-COMP:9684"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.7"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Subunit of the heterotrimeric GatCAB amidotransferase (AdT) complex, composed of A, B and C subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the amidase family. GatA subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.7" evidence="7"/>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QDX3"/>
    <dbReference type="STRING" id="1365484.W6QDX3"/>
    <dbReference type="OMA" id="QPASYCG"/>
    <dbReference type="OrthoDB" id="421993at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030956">
        <property type="term" value="C:glutamyl-tRNA(Gln) amidotransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050567">
        <property type="term" value="F:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070681">
        <property type="term" value="P:glutaminyl-tRNAGln biosynthesis via transamidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00120">
        <property type="entry name" value="GatA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000120">
        <property type="entry name" value="Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004412">
        <property type="entry name" value="GatA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895:SF7">
        <property type="entry name" value="GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE SUBUNIT A, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895">
        <property type="entry name" value="TRANSAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Amidase" evidence="9">
        <location>
            <begin position="17"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="114"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="132"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7">
        <location>
            <position position="139"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="7">
        <location>
            <position position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDM34923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="500" mass="53254" checksum="6181B452C9E03B82" modified="2014-04-16" version="1">MSLLREAERCVANQYTRGLNAFITPLLREGPWLDRVKEADVRKEEGKPKSAVDGRLISIKDNICTRDLPTTCASGILDEYVSPFNATVVDQLEAAGAIVAGKTNMDEFGMGSHSINSHFGPVRNPRQDSSGEDLSAGGSSGGSAASVAGDECYASLGTDTGGSVRLPAAYTGIVGFKPSYGLISRWGVVAYANSLDTVGILGKTTANVRDIFDILNQHDQCDPTSLSIHSRSRIQASLQTPQLASRLTSAPLRIGVPIEYNVSELTSSVRRAWALSLAHLKSQGHTLHSVSLPATKHALSTYYVVGPAEASSNLAKYDGVRYGTRAEGPDGDGKPDGCLFSKTRGEGFGEEVKRRILLGTFTLSADAIDNYFIKAQQLRRLVQQDFDAVFTAKHPLAAQDANKIAGEIDVDVIVCPTAPSSPPRLSDLMSKSIKKSPLDAYVSDVFTVPASLAGLPAISVPVTVSGQNDTELAGIQVIGQYGDDQLVMKVGELLEGRKLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W6QDZ5</accession>
    <name>W6QDZ5_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">dihydrolipoyllysine-residue succinyltransferase</fullName>
            <ecNumber evidence="5">2.3.1.61</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">2-oxoglutarate dehydrogenase complex component E2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PROQFM164_S02g002565</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FM164</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid degradation; L-lysine degradation via saccharopine pathway; glutaryl-CoA from L-lysine: step 6/6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.61" evidence="5"/>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QDZ5"/>
    <dbReference type="STRING" id="1365484.W6QDZ5"/>
    <dbReference type="OMA" id="NMPQTAV"/>
    <dbReference type="OrthoDB" id="5391403at2759"/>
    <dbReference type="UniPathway" id="UPA00868">
        <property type="reaction ID" value="UER00840"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045252">
        <property type="term" value="C:oxoglutarate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004149">
        <property type="term" value="F:dihydrolipoyllysine-residue succinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033512">
        <property type="term" value="P:L-lysine catabolic process to acetyl-CoA via saccharopine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06849">
        <property type="entry name" value="lipoyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.10:FF:000006">
        <property type="entry name" value="Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050537">
        <property type="entry name" value="2-oxoacid_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006255">
        <property type="entry name" value="SucB"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01347">
        <property type="entry name" value="sucB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43416:SF5">
        <property type="entry name" value="DIHYDROLIPOYLLYSINE-RESIDUE SUCCINYLTRANSFERASE COMPONENT OF 2-OXOGLUTARATE DEHYDROGENASE COMPLEX, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43416">
        <property type="entry name" value="DIHYDROLIPOYLLYSINE-RESIDUE SUCCINYLTRANSFERASE COMPONENT OF 2-OXOGLUTARATE DEHYDROGENASE COMPLEX, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="6" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="14">
        <location>
            <begin position="77"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="153"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="159"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CDM32414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="461" mass="50078" checksum="DB55625B6AA040F5" modified="2014-04-16" version="1">MASRIFIARLSGQRFSAVARTAPRGASQFRNVKGLSTLTRKASARSASGLLQVSSGINVSRLNLAPLGGHQLRTYADSIIKVPNMAESITEGTLKQFSKQVGDFVERDEEIATIETDKIDVSVNAPDSGVIKEFLVNEEDTVTVGQDLVRIELGAAPEGGKKDEGAEKPKEPEPKAPEPKEPEPKKEAPPAPTETEKPKAPEPKKAAPPKEAPKPQAAEQPASIGNREERRVKMNRMRLRIAERLKQSQNTAASLTTFNEVDMSSLMEFRKLYKEDTLKKTGVKLGFMSAFSRACVLAMKDIPAVNASIEGPNGGDTIVYRDYVDISVAVATEKGLVTPVVRNSEGKDMIGIEKAIADLGKKARDNKLTIEDMAGGTFTISNGGVFGSLMGTPIINTPQTAVLGLHAIKEKPVAVNGNVEIRPMMYMALTYDHRLLDGREAVTFLVKVKEYIEDPRRMLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W6QEU8</accession>
    <name>W6QEU8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S02g002880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QEU8"/>
    <dbReference type="OMA" id="LEMRVHH"/>
    <dbReference type="OrthoDB" id="4358431at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM32729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="86" mass="10124" checksum="AD8AE62C17FCD8E8" modified="2014-04-16" version="1">MITRHAGRNIRTDSSSPPSQRAKKVLEMRVHHRFHGSHVTFLEGQPGRPQRKGAKETPRRKGANSQREAIRLDWMRRLRPKPHRRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W6QGG6</accession>
    <name>W6QGG6_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Aromatic-ring hydroxylase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PROQFM164_S01g002533</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the flavin-dependent halogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QGG6"/>
    <dbReference type="STRING" id="1365484.W6QGG6"/>
    <dbReference type="OMA" id="RVIHSEH"/>
    <dbReference type="OrthoDB" id="3340390at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050816">
        <property type="entry name" value="Flavin-dep_Halogenase_NPB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006905">
        <property type="entry name" value="Flavin_halogenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43747:SF5">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43747">
        <property type="entry name" value="FAD-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04820">
        <property type="entry name" value="Trp_halogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDM28722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="504" mass="55215" checksum="73C058354D78ED12" modified="2014-04-16" version="1">MSIPEHCTVLIVGGGPGGSYAAAALAREGIDTVLLEADVHPRYHIGESMLPSMRYYLSFIDCDSTFDQYGFKKKATFTLNQANYEGYTDFIASGGPNHYTWNVIRSEADELLFRHAAKSGAKAFDGVKVNSIEFAQPPASNGTAGNESDVSALGRPVSASYTLKSESVSGAVKFDYIIDASGSKGLLSTKYLKNRTFNQGLKNVASWGYWRSTGKYGIGTAREDSPYFEALIDESGWAWFIPLHDNTTSVGVVMNQEIMNKKKAASGLSSRDFYLSSLKLAPHLNEFLSGGELVTGIKSASDFSYSSSSYAFPYARIVGDAGCFIDPYFSSGVHLAITSALSAAVTVSAAIRGDFEEEIAAKWHSNKVKAGYSRWLLVVLSTYKQIGNQKEPVLSEYGEDNFDRAFNFFKPIIQGTADTTNKLTQAEFSKSFHFCVKAFDRYKNKTDSEEPTSKEEEKMLAEFRSTQAKTWNGIDSFTTDDIDGRVPRLERGNLGLMSVIVAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W6QHG8</accession>
    <name>W6QHG8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S05g000071</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QHG8"/>
    <dbReference type="STRING" id="1365484.W6QHG8"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM36238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="240" mass="25822" checksum="BC351482B60E7335" modified="2014-04-16" version="1">MLYERIANLSTCVRLRMGIWNTIKCMKRESAVPTTSTRSRSDANPDSARRESAVPTTSTRSRSDANPDSARRESAVPTTSTRSRSDANPDSARRESAVPTTSTRSRSDANPDSARRESAVPTTSTRSRSDANPDSARRESAVPTTSTRSRSDANPDSARRESAVPTTSTRSRSDANPDSARSSGKTGVSWDSSMLPGDPTATSLDLSVVLLTSSLLVKPTQAHILLQSPSPLQYPTSHSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W6QI77</accession>
    <name>W6QI77_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glutathione transferase</fullName>
            <ecNumber evidence="2">2.5.1.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">gst2</name>
        <name evidence="9" type="ORF">PROQFM164_S04g000602</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in the oxidative stress response and detoxification.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the GST superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.18" evidence="2"/>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QI77"/>
    <dbReference type="STRING" id="1365484.W6QI77"/>
    <dbReference type="OMA" id="NPWKVIM"/>
    <dbReference type="OrthoDB" id="422574at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd03048">
        <property type="entry name" value="GST_N_Ure2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.130:FF:000016">
        <property type="entry name" value="Glutathione S-transferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051:SF3">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR URE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01151">
        <property type="entry name" value="Main.2:_Nu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="7">
        <location>
            <begin position="4"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="8">
        <location>
            <begin position="92"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00060024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM35721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="216" mass="24646" checksum="BBFABD07DFB321F9" modified="2014-04-16" version="1">MSLKPITVYGHATGPNPWKVIMILEELDIPYIHKFINFADMKKEPFESINPNGRVPAIEDPNTDTTLWESGAILEYLVDTYDKQNTISFATGSKDYYLAKQWLHFQVSGQGPYFGQAVWFSRYHPEKVQSAIDRYVSEIRRVSGVLNRALQGKQYLVGDKFSYVDAAFVPWYQITGRFGIDMGKEFPNVAAWLKLVQERPAIAKTVQDRAEASAQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>W6QI78</accession>
    <name>W6QI78_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 13">Fructose-bisphosphate aldolase</fullName>
            <shortName evidence="13">FBP aldolase</shortName>
            <ecNumber evidence="5 13">4.1.2.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">fbaA</name>
        <name evidence="14" type="ORF">PROQFM164_S03g000613</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 13">Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>beta-D-fructose 1,6-bisphosphate = D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:14729"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.1.2.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12 13">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="12 13">Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 13">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 4/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the class II fructose-bisphosphate aldolase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.13" evidence="5 13"/>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QI78"/>
    <dbReference type="STRING" id="1365484.W6QI78"/>
    <dbReference type="OMA" id="PRTWGKL"/>
    <dbReference type="OrthoDB" id="35652at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00183"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004332">
        <property type="term" value="F:fructose-bisphosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00946">
        <property type="entry name" value="FBP_aldolase_IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000013">
        <property type="entry name" value="Class II fructose-bisphosphate aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000771">
        <property type="entry name" value="FBA_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006411">
        <property type="entry name" value="Fruct_bisP_bact"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00167">
        <property type="entry name" value="cbbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01520">
        <property type="entry name" value="FruBisAldo_II_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006628">
        <property type="entry name" value="PRK09197.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30559:SF0">
        <property type="entry name" value="FRUCTOSE-BISPHOSPHATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30559">
        <property type="entry name" value="FRUCTOSE-BISPHOSPHATE ALDOLASE CLASS 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01116">
        <property type="entry name" value="F_bP_aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001359">
        <property type="entry name" value="F_bP_aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00602">
        <property type="entry name" value="ALDOLASE_CLASS_II_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00806">
        <property type="entry name" value="ALDOLASE_CLASS_II_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="9 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12 13" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="110"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>dihydroxyacetone phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="267"/>
            <end position="269"/>
        </location>
        <ligand>
            <name>dihydroxyacetone phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="288"/>
            <end position="291"/>
        </location>
        <ligand>
            <name>dihydroxyacetone phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001359-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001359-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001359-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU366023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDM33889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="360" mass="39434" checksum="4EC730275BA8B05D" modified="2014-04-16" version="1">MGVLEQLNRKSGVIVGDDVLRLFEYAKQKGFAIPAINVTSSSTVVASLEAARDDKCPVILQISQGGAAYFAGKGVSNEGQKASIAGAVAAAHYIRSVAPAYGIPVILHTDHCAKKLLPWLDGMLDADEAYFKLHNEPLFSSHMIDLSEEPVDYNINTTAAYLKRVAPMKQWLEMEIGITGGEEDGVNNEDVDNNSLYTQPEDILAIQNTLAAISPYFSIAAGFGNVHGVYKPGNVKLHPELLSKHQKYVKEQTGSSSDKPVFFVFHGGSGSSKEEFKEAISYGVVKVNVDTDMQYAYLTGVRDFVLKNKDYLMSQVGNPEGADKPNKKFFDPRVWVREGEKTMSKRVKEALEDFNTAGQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W6QJF7</accession>
    <name>W6QJF7_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Aromatic-ring hydroxylase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PROQFM164_S04g001027</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PheA/TfdB FAD monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM36146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QJF7"/>
    <dbReference type="STRING" id="1365484.W6QJF7"/>
    <dbReference type="OMA" id="IYDIAFW"/>
    <dbReference type="OrthoDB" id="5325318at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016709">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05352">
        <property type="entry name" value="MDH-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012941">
        <property type="entry name" value="Phe_hydrox_C_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038220">
        <property type="entry name" value="PHOX_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050641">
        <property type="entry name" value="RIFMO-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004:SF4">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004">
        <property type="entry name" value="TRK SYSTEM POTASSIUM UPTAKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07976">
        <property type="entry name" value="Phe_hydrox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="287"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="domain" description="Phenol hydroxylase-like C-terminal dimerisation" evidence="7">
        <location>
            <begin position="674"/>
            <end position="871"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM36146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="875" mass="96214" checksum="8415B7CFE6B33A35" modified="2014-04-16" version="1">MSEGKGFTTQQDNIQLHCDMSRFSLKGRTALVTGGARGCGLAFARGLAEAGADVAVFDVISPEEGFHAIEKDCGVRTAYYKVDVSSQESLQEGFASFQKDFENALDICVPCAGINRHLPFLEFTYKDHQDLLSINVLGLYFTAQLAAKQMIANKTKHGSIVLVASMASHIAVRSQLCSAYCGTKGAVRSMCPAIAKELAEYGIRVNSISPGFVKTEMTASFPHLLEGWKSEVMNGRIAEPEDIMGACIFLASDASSYMTGSDIVVDGGVTRCADHEGYRIGSVDASTTVVVVGAGPSGLMLACNLVRFGIAVVILDDRPDKTSTGKADGMQPKTIETFRQLRLADPLLRNGARVYDISFWESTANDSLRRTGRKVHYPEHVGASDPYILLAHQGMVEEVMIDDMEARGVSITRNSKFVSCSPVNGTTQLDIIYEDVTTNTAHKIRANYLVGCDGARSKVRSFIPDAELEGELTNAAWGVLDGVIDTDFPDLWSKVALRSHSAGSILWIPREKGMTRLYVELSSTDGERVEKSKATTEYVMSRAREAMHPFSLEWKTVEWFGTYVVGQRVAKRFMDSEANIFIAGDAGHCHSALAAQGANTSMHDSFNLAWKLNLLVRGLAKPSLLHTYEEERQKIAYDLINFDVEHCKAFAAGDEELAKNFDSNIRFISGIGAEYAPGMLTQAPTTTARLQPGMLQLPAKVTRYIDANPVDIELDVPLLGQFKIYIFVPNVYRSRESLENICEQLQYILAGVSVRANQSYEKHPRGHSPSDEFVQAQRYTSVSNAFTFAMVTQSSQSEFEIADLPEILQASRWTLYVDNIGGPSCTEKWFGDLNQEKIGIAVVRPDGYVGAIDTWDTEQVGVIGQWLQDYFSFLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W6QJK6</accession>
    <name>W6QJK6_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S03</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S03g001113</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QJK6"/>
    <dbReference type="STRING" id="1365484.W6QJK6"/>
    <dbReference type="OMA" id="THVFGTK"/>
    <dbReference type="OrthoDB" id="4422269at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM34389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="554" mass="63314" checksum="5A3D0B8EE525845E" modified="2014-04-16" version="1">MALFIPMSLVPLCFPTPPTPKTEFQTLPAEIKLLIIDQLDRDTYTLSHLAACNRELYNMAIPALYANVSLGAVPHYRMWPGLAFPADRRSIERFLITILRKPHLAEFVKSLDVTDLHDLCFEHRQSSTQRRQLLLNPLAPQDHQMIMDAAMKLPLYSTIRVAMRKALGCDVPRSDAMVAVLLGYLPALKHLEIAMESEDPFREPQTTELNLIERVLISIAGARSAQTDENGISNALTPTLSKLTHLKAEVDGKSPMADIDWLMMLLRIPTLTHVFGTKWSNAQRWLRPVPGSSHRLVHLELRDCTFDALNLRRLLRQTHILETFIYERGWTEAKDWVVKAADLSQALQYRSHTLTCLELSFNRTDRKIHEELYLHPLNLSGLSHLKRLRISAGYLVQTETKSAHYEGRHWRLHDVDGAYNRNLPLHKLLPESLEELHIIQILDVLEFMLLCEKLCASLQSRIVPMSLEPHHFECLKEIKIEAPFEGEGECIFSELSRVTNQAGVKLTTIENSADYVKSWITGKSKPSCADKKIDWGFDGDVRWARPFIQRGVTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W6QK18</accession>
    <name>W6QK18_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phospholipid/glycerol acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S05g000573</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QK18"/>
    <dbReference type="STRING" id="1365484.W6QK18"/>
    <dbReference type="OMA" id="YTHFKDD"/>
    <dbReference type="OrthoDB" id="2427554at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004366">
        <property type="term" value="F:glycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016287">
        <property type="term" value="F:glycerone-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07992">
        <property type="entry name" value="LPLAT_AAK14816-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052744">
        <property type="entry name" value="GPAT/DAPAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31605">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE O-ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31605:SF0">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE O-ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="433"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="483"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="518"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="3">
        <location>
            <begin position="49"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="607"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="607"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="627"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="691"/>
            <end position="717"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM36740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="740" mass="81768" checksum="F42492C3E1D01E94" modified="2014-04-16" version="1">MGEKGQYIPPLVGWMYDLVLWSFSVLIDLFFREVHPRGSWKIPRRGPIILVAAPHANQFVDSLVLMRVIRSEAHRRISWLIAEKSFKRKFIGFLARAVGTLPVARAMDNLKPGTGTIYLPDPVNQPTLLRGVGTNFEGKGFQKDGTIALPTINGTSYSTAIAEIKGPEELILKKAFTSKDALTQLTGRQDIDRDGNFTGDASAQDPDFKGTKFKVAPHVDQTAVYQAVFKRLGAGGCVGIFPEGGSHDRTTLLPLKAGVALMALGTLAENPDCGLKIVPCGMNYFHAHKFRSRAVIEFGNPIEIPSELVEQFKQGERRESVGALLEIIYGSLVSVTVISPDYDTLMVIQAARRLYNTKGKNLPLPMVVELNRRLVKGYAHFKDDPRIVALRKSIVGYNKQLHLLGIRDHQVAYAKFTILQVVATLIYRLGKLALLTIGTLPGFLLFTPVFIATKYISAKKSREALAASTVKLQGRDVMATWKLLIALAFAPALYAFYTAALTYWTYWNRVNGLVPDWVPLWSIVVIGMVLFPTVTFAALRIGEVGMDIIKSLRPLVLSLNPSSANTLVKLRARRVALAQQVTDAINTMGPELFPDFDAARIVTDPFRDASDTDTKADNGLPAIRRTSVPEHGEKMPSSEPLPRNESFHNLANIGFFSTRPPSRNRSRSRSASARPGSRHGLKPLSTLTPKDPLEDVSSRIRDAMRERGERRRRRSEDGSWDMASSGPGTPSSGDESRKDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W6QK69</accession>
    <name>W6QK69_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BRCT domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S05g000618</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QK69"/>
    <dbReference type="STRING" id="1365484.W6QK69"/>
    <dbReference type="OMA" id="SWLYHLI"/>
    <dbReference type="OrthoDB" id="342264at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035361">
        <property type="term" value="C:Cul8-RING ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990683">
        <property type="term" value="P:DNA double-strand break attachment to nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18436">
        <property type="entry name" value="BRCT_BRC1_like_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18437">
        <property type="entry name" value="BRCT_BRC1_like_rpt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17743">
        <property type="entry name" value="BRCT_BRC1_like_rpt5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10190:FF:000066">
        <property type="entry name" value="BRCT domain protein (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10190:FF:000048">
        <property type="entry name" value="DNA repair protein Rtt107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053036">
        <property type="entry name" value="CellCycle_DNARepair_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47667">
        <property type="entry name" value="REGULATOR OF TY1 TRANSPOSITION PROTEIN 107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47667:SF1">
        <property type="entry name" value="REGULATOR OF TY1 TRANSPOSITION PROTEIN 107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16589">
        <property type="entry name" value="BRCT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12738">
        <property type="entry name" value="PTCB-BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16770">
        <property type="entry name" value="RTT107_BRCT_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="6"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="104"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="238"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="340"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="611"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="459"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="569"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="569"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="584"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM36785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="850" mass="95135" checksum="21F4D4B10FBBEC36" modified="2014-04-16" version="1">MAAENGDSKLFEQCCFCIVCSKDLSNESAEQLATLIEQNGGEPLIVQPGAEVPDVAKFSHMISTTIDFQAYGTACDALIPVVKPQWVNNSLTKRKLANPRQYSPDPRLFMNDVVVTCGDIPEGDKDAIIGGVVAKGGLYSPRISQQVTHLVDLTADSDKARILQAKRLNVKIVLPHWFDDCLKLGRRIDERPYTLPDPEILRAGPDTPIRWQDNKDLVGASTTNPSKLPTPSSAHQSGQRSVFEGKSIMLSPDLAIGSHLQESIQAVLEQGGAKVTSNIDVADMLICRYREGFSYRTASRLNIDVGNLAWLYHLMTFNTYTSPLRRLLHYPVSRTGIPGFEGLKISLSNYVGEARIYLENLIAAAGAECTKTLKQENTHLITAHGMSEKCNAAKEWGLEVVNHLWLEDSYAKWKLQPASNPRYSHFPLRTNLGEVAGQTPLDRHVLEQVFFSSEENIAHSPRRAMQSKNQNMVSVQPPAEKKRKIDEDAPETSLGTPQGNGKSRRPIQTPARTRVMSEGKENETPSSTSSRKSKEAAAARLHEYVPDLALYEKERKRVGGVIYGGRRKSDEGRVQENKKRASPEAEDESDGEQAVETKRQKKSRPPIAMHLLITGYQRWVGKGNEKKEDADKRGLRDLGIMVVQDARRCTHLAAPSILRTTKFVNALAYAPMILSTKFIDSCLKEEKLLDPSDFPLEDKEAEKKYSFDLSSVTKNAKKNKNKMLQGYRIYCVEDIRGGFDAFKSIVETNGGECMLYRGRLAIKNHSRREESDEESESEDGSPVRKDVFLLSSTGANHARVWPRFRQLAVDIKKTPRIVRVDWLLDMAMSQQTRAADEYELTDEMIETMDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>W6QLD4</accession>
    <name>W6QLD4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Laccase-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">yA</name>
        <name evidence="11" type="ORF">PROQFM164_S02g000511</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the multicopper oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QLD4"/>
    <dbReference type="SMR" id="W6QLD4"/>
    <dbReference type="STRING" id="1365484.W6QLD4"/>
    <dbReference type="OMA" id="WEEGAPN"/>
    <dbReference type="OrthoDB" id="2121828at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052716">
        <property type="term" value="F:hydroquinone:oxygen oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042440">
        <property type="term" value="P:pigment metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd13850">
        <property type="entry name" value="CuRO_1_Abr2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13876">
        <property type="entry name" value="CuRO_2_Abr2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13898">
        <property type="entry name" value="CuRO_3_Abr2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000036">
        <property type="entry name" value="L-ascorbate oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF488">
        <property type="entry name" value="LACCASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0186">Copper</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004879705" evidence="7">
        <location>
            <begin position="21"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="10">
        <location>
            <begin position="31"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="8">
        <location>
            <begin position="171"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="9">
        <location>
            <begin position="448"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDM30362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="586" mass="65164" checksum="ECD2897F50BF1A7D" modified="2014-04-16" version="1">MTHTKSLFLTLMGAAALSQAAKVHYDLDLTWKRGAPNGVEREMIFVNDRFPGPPLILDEGDEVTIDVTNNLPFNTSVHFHGIEQTNTPWADGVSGLSQWAIKPGDKYRYHWKATTYGTYWYHAHDKDRIMDGLYGGIRIRPSADRESPFSMISDDPADIQAMTKAAHDAQLVVMSDWDHLSSNEYMDALKETGYDIFCSDSILIDGAGSVYCKDPEYLTNLQPPQVRAVITEPLTDKGCDPFMPVLQGNWEHHPELLPEGLNSGCKPSEGPTSSFEVSPKNRWASLNFISAASLKSLIFSIDEHPMYIYEVDGRYIEPQLAHQVSIYSGERYSAMIKLDKEPGSYTIRVAGHDNQVISGYANLAYKGGEHNKRESTAYIDYGGTNTTASVINLNTTNLPPYPAILPAEDGDDFHLLTLGRINSSWEWTLDGTTFLPANLNQMEPVILNPKAPSLDSALKIETRNGTWVDIVFQLAIPDPTKLQPPHPMHKHSNKAFLIGSAMGKFQWGSIAEAKASSPDSFFKTPVYRDTFVTAPNGVAWIAIRYQVVNPGPFLLHCHMETHFSSGMGMVLLDGVDAWPEVPPHYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W6QLQ3</accession>
    <name>W6QLQ3_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sas10/Utp3/C1D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PROQFM164_S02g000646</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SAS10 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QLQ3"/>
    <dbReference type="STRING" id="1365484.W6QLQ3"/>
    <dbReference type="OMA" id="KSMKPVW"/>
    <dbReference type="OrthoDB" id="1924577at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007146">
        <property type="entry name" value="Sas10/Utp3/C1D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018972">
        <property type="entry name" value="Sas10_C_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13237:SF8">
        <property type="entry name" value="SOMETHING ABOUT SILENCING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13237">
        <property type="entry name" value="SOMETHING ABOUT SILENCING PROTEIN 10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09368">
        <property type="entry name" value="Sas10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04000">
        <property type="entry name" value="Sas10_Utp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sas10 C-terminal" evidence="7">
        <location>
            <begin position="553"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="318"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="373"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="563"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="124"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="10"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="58"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="320"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="399"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="409"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="451"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="489"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF09368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM30497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="627" mass="70846" checksum="65123F11704DBF24" modified="2014-04-16" version="1">MGSKKRKAGRPAENKAPEPSKFDIEERFDDSEDDFQTGRDQILLEEGPEAKRRRRVAEEEELIQPSDEEILGYESIDEDDDLEDSEEDDEYDDMGQPKKGDAESEEDEEGIAAWGSSKKDLYNADQIETEVDALEEEQEAKRLQMKQLQAMNEADFGFDESEWVESGKGTEDGADAGVVTEVLPQLEITDDMDTDEKLKILKSRYPEFEPLAKDFVDLQSSFKDLQQAALKASSTDDDSEEPQPSPVPVVKFRALSAYLGTISMYFMLLSSPSPDATSEHVPMTPAELRQHPVMGSLVKFRKLWNTVKDLEELEEPVGEPIKETKTEKTKTEKQPKTQEIKKPKQKKLSKAEIAQAEAEALRAERLRQTEAGLADLENLATEPSRKRKTQKIKAPLKDDDSDFGDEDALTAHEAEEKAKQKRSLRFYTSQLAQKANKRNAAGRDAGGDADLPYRERLRDRQARLNVEAEKRGRKELNPDQQLGGDSDDEDRRVAKELRRGEGAKEGTDDDEYYDMVASRSKKRKDDKQARADAYAEAERLGGKIFVQEEVGPDGKRAITYQIQKNKGLHAKRSKDSRNPRVKKRKKYEEKKKKLGSTKQLYKGGEGRGGYGGELTGIKKNLVKSVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W6QLR2</accession>
    <name>W6QLR2_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">X-Pro dipeptidyl-peptidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S02g000656</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QLR2"/>
    <dbReference type="OMA" id="FHEMIPG"/>
    <dbReference type="OrthoDB" id="5959877at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010281">
        <property type="entry name" value="DUF885"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33361:SF15">
        <property type="entry name" value="DUF885 FAMILY LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33361">
        <property type="entry name" value="GLR0591 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05960">
        <property type="entry name" value="DUF885"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM30507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="562" mass="65426" checksum="C600BB439187C60B" modified="2014-04-16" version="1">MVSVTSPRGIAIQRAQVDTIRDRIERITEDLKDIKEFFPIKISPRRTQKLRQFLTSELDSLRSQPFDLYDQQGKVDYILMKNYLERQLRELELDCKQDEKTALLLPFSGKLLELCEARVMVLSMNAKDAAQKLVESQAQISAVIDMVKGDSTKFRMEKTIAFRAARNIDSLHDNLKEWFEFYKGYDPSFNWWVSHPYGVVEKGLKDVSASIRENLAGIRPDNDDAIVGDPIGREGLLSELLGEMIAYTPEELISIGEKEFKWCVGELKKASRSMGFQDNWKQALEEVKNDFVEPGKQTGLVRDLTVEAISFVEDHQLVTVPPVAKENWQMFMMSPERQKVNPFFLGGECIIVSYPTDQMDHEAKLMGMRGNNIHFSRATVFHEMIPGHHLQMHMIARYRPYRRLFDTPFWIEGWALYWEFILWNDERFRKTPQNRIGMLFWRLHRCARIIFSVKFHLGQMAPEECIDLLVDQVGHERATAEGEVRRSLNGDYSPLYQAGYMLGALQIYALRKETVETGLLAEKEFHDRFLKENCMPIELARALMQDQSLSREHKPSWKFYSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W6QNB1</accession>
    <name>W6QNB1_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Splicing factor, CC1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PROQFM164_S11g000081</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792025">
        <property type="protein sequence ID" value="CDM38378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QNB1"/>
    <dbReference type="STRING" id="1365484.W6QNB1"/>
    <dbReference type="OMA" id="GRDNDKG"/>
    <dbReference type="OrthoDB" id="5411533at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12283">
        <property type="entry name" value="RRM1_RBM39_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12284">
        <property type="entry name" value="RRM2_RBM23_RBM39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12285">
        <property type="entry name" value="RRM3_RBM39_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000876">
        <property type="entry name" value="RNA splicing factor (Pad-1), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000172">
        <property type="entry name" value="RNA splicing factor Pad-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029123">
        <property type="entry name" value="RBM39_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006509">
        <property type="entry name" value="RBM39_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01622">
        <property type="entry name" value="SF-CC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48036">
        <property type="entry name" value="SPLICING FACTOR (PAD-1), PUTATIVE (AFU_ORTHOLOGUE AFUA_1G15810)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15519">
        <property type="entry name" value="RBM39linker"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="166"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="266"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="343"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="14"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="30"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="50"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="85"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="119"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM38378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="553" mass="61900" checksum="C9B19B9C014D44DF" modified="2014-04-16" version="1">MSGLDVEALLESTAAAPIEAPVEAPATSDSRADPTERRDRSRDRRRRRDHSRDRRPDRDLQGDEVAKSDTVSANGSLRSRKRSKSRESERRRSRRDRDGYRSNGDFYRGGGRVRSRSRSPYDDRHYRPNRRQREEERRPRRDADVRRGSAASRKSPELNEDERDSRTVFVQQLAARLRIKDLIAFFEKAGPVKDAQIVRDRVNGRSKGVGYVEFKNEESVSAAIRLTGQMLAGIPVIAQLTEAEKNRQAARNPEAPAGNHHTAPFHRLYVGNVHFSITEKDITNVFEPFGDLEFVQLQTDESGRSKGYAFVQFAHPDQARNALEKMNGFDLAGRNIRVGLGNDKFTPDSHANRASGASTNFQGSSFSGQGGRGVQAGGSNNFDRAGGRETEKGAGASALDDTDVAGVNFNNYSRDALMRKLARTDEPQSSVDDRQKFLRPKTETKPLPINVNMASRCVLLRNMFDPALEHSPTWVKDLEEDVRTECEKKYGHVVHISLDPNSVGDIYLKFDRVQGGENAIKGLNGRYFGGKMCTAQPVVDAVYSSLFSRTRAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W6QPA1</accession>
    <name>W6QPA1_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Major facilitator superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PROQFM164_S07g000159</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792021">
        <property type="protein sequence ID" value="CDM37811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QPA1"/>
    <dbReference type="OMA" id="NWAVTRI"/>
    <dbReference type="OrthoDB" id="5667at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17352">
        <property type="entry name" value="MFS_MCT_SLC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF224">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="68"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="227"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="268"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="306"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="336"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="360"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="397"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="430"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="70"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="27"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="48"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDM37811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="504" mass="54166" checksum="68AC42C94C9F3BBF" modified="2014-04-16" version="1">MANKQTGMAPSIDSTTTTPAVSVHGNNDPEKGLPSEKKEAQPVEKSVAAGPAPSAPAIGPPPDGGAQAWLVVLGAFCGLFVSFGWINCIGVFQTCYQSHQLSEFSTSTVTWITSLETFMMFFCGPIFGTMFDSYGPRWVLLLGTFLHVFGLMMASLSTEYYQFILAQGICSPIGASAIFNASVNSVSTWFAKRRGFALGVTASGSSLGGVIFPIMVSQLIPKVGFPWAMRICAFLILFMLGIANLTLKSRLPHHPKPFHIKLFLRPLAEIKFALTLAGAFFFFWGMFLPFTFVITQAERYGMSGDLSGYLIPILNAASILGRTLPGYYADKVGRYNMMVITTFFSAIIVLALWLPSRGNAPAIVFSALYGFGSGAFVSLAPALVAQISDLRQVGVRNGTFFAVISFAALTGTPIGGALVPDVLHGSYTKLQIFCGVVMIVGSVFFVFARGAVGGFKLNKNTEYLHITISAVYVGFGPSDIWDGLEQGVTAPGRLKLRCRSMFVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>W6QPC5</accession>
    <name>W6QPC5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Mitochondrial carrier protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PROQFM164_S07g000189</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792021">
        <property type="protein sequence ID" value="CDM37841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QPC5"/>
    <dbReference type="STRING" id="1365484.W6QPC5"/>
    <dbReference type="OMA" id="WVTATPF"/>
    <dbReference type="OrthoDB" id="193856at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000184">
        <property type="entry name" value="Mitochondrial carrier protein, putative (AFU_orthologue AFUA_6G12900)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF10">
        <property type="entry name" value="SLC (SOLUTE CARRIER) HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="94"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="188"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDM37841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="307" mass="33540" checksum="35C381ABE9608570" modified="2014-04-16" version="1">MAADFWAGYISGAIGIIIGNPLDVIKVRLQAGHSHADASRAQLSRFEKASSLVRGAAAPILGYGALNAILFVAYNRSLAALDGSVTDPTNPVGVSAYKIWLAGAVGGLASWTISSPTEFIKCRAQLDRRPDVSSWTVAKDIFRTRGWRGLYFGGLITSARDSIGYGFYFWSYELCKRFLTSHDEGSHQAALKILLCGGIAGVVTWGSVFPLDMIKTRLQAQTITDYAPGTESQSLLRSQRQTLNSFQIAKEVYHVEGIKAFYRGLGVCSVRAFIVNAVQWAAYEWLMKSFNHSWDARVTSQEPIAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W6QPJ3</accession>
    <name>W6QPJ3_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S11g000018</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792025">
        <property type="protein sequence ID" value="CDM38315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QPJ3"/>
    <dbReference type="OrthoDB" id="5228066at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM38315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="66" mass="7155" checksum="75081EDC115F7707" modified="2014-04-16" version="1">MKPPPKAIAVIVDVIESQGAIHITDDDGSYIDMVGTEFAGHLVLVPWDKSWFLRASGSIEVGYVIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W6QPQ9</accession>
    <name>W6QPQ9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dimeric alpha-beta barrel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S08g000032</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG792022">
        <property type="protein sequence ID" value="CDM37981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QPQ9"/>
    <dbReference type="STRING" id="1365484.W6QPQ9"/>
    <dbReference type="OMA" id="DWYNTEH"/>
    <dbReference type="OrthoDB" id="2851338at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43039">
        <property type="entry name" value="ESTERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="293"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM37981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="553" mass="61837" checksum="773141947CCE0EB8" modified="2014-04-16" version="1">MPTPGLLYVTMQPKGSLPDTQFHDWYNTEHGPLRLRLPFVTNGFRFRATDGEQPEYVALYDITDMDELTRKTYLDLRTDMIKTEREKKTMAQIDVGRLLYDLVDERSNTNFRPLEDQADTDAETRGSVLVAVRVATHPDPAKEADLDKWYREEHFEMLSRVPGWRRSRRFVTAAIDSAAPRESLTLHEYAPVNGLGGEAHKAAMNTPWGSRLMSEVVTSKKRRVYEWYYTFGPAPRELTSLAAPDVVGPWSSNDGRTRTFPSTTRPAVESFITTSDGVEIPYRLEGSRDPYAPVVVLSNSILVNWNIWDRFLDAFFAQQQNQRYRVVRYLTRGRRSQSGEQPVNIDLLASDLATLLEALRVPPKAARLIGVSLGGVTVLNTALLHPERVGAFIACDTNSSAPESNRKAWGDRVAICEKEGSTDPDTNEPIVGEELAEVTTRRWFVPESYQAQPEVLAPVKEAVRTNSLKGFAHSVQALCAYDIRERMAAATVPGLFIAGANDGVLPQTMQKMAADLHGGAELKLIDRAGHLPMVEQPVAFEKVVTEFLGKIDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W6QPU3</accession>
    <name>W6QPU3_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Signal recognition particle, SRP19 subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PROQFM164_S02g001742</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QPU3"/>
    <dbReference type="STRING" id="1365484.W6QPU3"/>
    <dbReference type="OMA" id="NPFKEAM"/>
    <dbReference type="OrthoDB" id="2190947at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006617">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.56.30:FF:000003">
        <property type="entry name" value="Signal recognition particle SEC65 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.56.30">
        <property type="entry name" value="Signal recognition particle, SRP19-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002778">
        <property type="entry name" value="Signal_recog_particle_SRP19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036521">
        <property type="entry name" value="SRP19-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17453">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 19 KD PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17453:SF0">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 19 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01922">
        <property type="entry name" value="SRP19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69695">
        <property type="entry name" value="SRP19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0733">Signal recognition particle</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="265"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="40"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="53"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="279"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDM31592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="290" mass="31452" checksum="AC2E7F5B489DD730" modified="2014-04-16" version="1">MSRRAQIEEVSDSDPEEIAPSYDSDEDLPRNAIIAPVNIPRAAPQPQQQQMPMPQPMPSMPAPEPQREIPRHFSCLYPVYFDKTRSRAEGRKVGAELAVENPLARDIVDAVQMLGLNAGLEPEKLHPKDWANPGRVRAQVRTQDGQLANPKIKNKHHLYILVAQYLKANPTTEKSPYRLRIRGLPMPEKLPAAPAAPRGWKIGTILPIHSPAYSGGGVSDNPLKDAMAEMQGMEGMPNMSEMMSQMGGMGGLSSMLGGLGGLGGMGGMGGEPSGAGAEKKKKEKRKVIRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W6QPZ5</accession>
    <name>W6QPZ5_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PROQFM164_S14g000014</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792028">
        <property type="protein sequence ID" value="CDM38515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QPZ5"/>
    <dbReference type="STRING" id="1365484.W6QPZ5"/>
    <dbReference type="OrthoDB" id="2496787at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF143">
        <property type="entry name" value="EXTRACELLULAR MEMBRANE PROTEIN CFEM DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Rhodopsin" evidence="6">
        <location>
            <begin position="124"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM38515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="228" mass="25610" checksum="E6DA2CD3761E7D85" modified="2014-04-16" version="1">MNRTGPVTNHVVAKHRLSDDWPGSSEVGAGTDVFDPLDPALFSHGPIKQIMLAEICYMAAEALRHLFFLPLYLRIFPSEQFQLIAYVLMGLSACFGFSNTCHDIPVPTYPILLVRLDWGVPRNVITVVSCLRLRSLVKFSKSPNTTYANTLAIYWSVLECDVPIICACMPAIPSLPRNISSILFRQSPNYRDDTSPLRHAPQSIPLDRNQKDEKCRNLQVTSSETYLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W6QQI7</accession>
    <name>W6QQI7_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="4">YL1 nuclear</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S05g000167</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS72/YL1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QQI7"/>
    <dbReference type="STRING" id="1365484.W6QQI7"/>
    <dbReference type="OMA" id="PVISYWS"/>
    <dbReference type="OrthoDB" id="3942062at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013272">
        <property type="entry name" value="Vps72/YL1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046757">
        <property type="entry name" value="YL1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13275:SF4">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 72 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13275">
        <property type="entry name" value="YL-1 PROTEIN TRANSCRIPTION FACTOR-LIKE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05764">
        <property type="entry name" value="YL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08265">
        <property type="entry name" value="YL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00993">
        <property type="entry name" value="YL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vps72/YL1 C-terminal" evidence="3">
        <location>
            <begin position="639"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="59"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="289"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="569"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="696"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="59"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="289"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="331"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="347"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="404"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="442"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="480"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="530"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="569"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="722"/>
            <end position="739"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM36334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="749" mass="81310" checksum="14FEE26905E5822F" modified="2014-04-16" version="1">MADIMEEDPSSAVQSSEGEEMPVESLVRGRAKRSTAGLHMSALLEAAADDDLSLLFEEVEDDNEFADVADPDAEDELLESSDEDEDQGPNAQNDYEGEQKLQKDERKKRRAQNDLRFQTLRKRVKIDPTAPSTMSAAPRPKKKSERISWIPTVEDGPTRQSSRRQTMVNKELTHARLKDSQEKRVRIIATMKEAEKRKAHLKPKQMTQEDHLAEAARVERLNSKSLNRWELSEKRKADERRARIEALQNRRLDGPVISYWSGVATWTNGRLTRVGKIDIRPKVDKDELRKKKKEKEDKEKAAAELKALGSTTGTSQPPYFHVVVGPPESLPPSTSTVDQPTGNKPPENAAPTAENTDTAENTNTPLVSGTNAGQPDGIPETKTIMETSTEQGKDNAMEKAPSVDANTSVPPEQDQSITAEGQSSESKNYGRLRFAVEIPASHHTSISADNGSIQKSPDVPTKTEDAMDIDSPVAAAAADSTKNQKVLESTDQTSLATPHVAAQPTSAEPIAHAAGTTVPEPPPLDGSRPVESATAVSSEVSLAPQALPAPAATSQATVPENAIVRSLNQPSTLPSESQLSNGLVKEPAPEIPEPPPVIEQTGRCLTILENFDYATANNRKYSMYFNAKKLGRLTKISSSLCVITSLPSRYRDPETALPYANSYAYSQIRRMLSEGYIWSSMLGCFVGPAEAARGVPERFTGKPGPGTVKLTDEGQAETPGNALTEAPSTPTPAASRAAPPTEPMEIDKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W6QQX6</accession>
    <name>W6QQX6_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycoside hydrolase, superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S05g000312</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QQX6"/>
    <dbReference type="STRING" id="1365484.W6QQX6"/>
    <dbReference type="OMA" id="SYFMVAQ"/>
    <dbReference type="OrthoDB" id="43654at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071966">
        <property type="term" value="P:fungal-type cell wall polysaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000271">
        <property type="entry name" value="Alkali-sensitive linkage protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053183">
        <property type="entry name" value="ASL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024655">
        <property type="entry name" value="Asl1_glyco_hydro_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34154">
        <property type="entry name" value="ALKALI-SENSITIVE LINKAGE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34154:SF10">
        <property type="entry name" value="ASL1-LIKE GLYCOSYL HYDROLASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11790">
        <property type="entry name" value="Glyco_hydro_cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004880039" evidence="1">
        <location>
            <begin position="20"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="Asl1-like glycosyl hydrolase catalytic" evidence="2">
        <location>
            <begin position="32"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM36479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="263" mass="27753" checksum="B34A460DAFC62DAF" modified="2014-04-16" version="1">MVSFTKLFTAGLVATSAMAAPMHAKRSSSKRGAAYNDISTVSALADAGTISWAYNWAGDLSGSLPSGVEYVPMLWGQNMFGGWVTAIQTALSSGSTYILGFNEPDMTSQANMSPSDAASYYQTYITPWSGQAKLISPAVTSSTTAGLGLDWFESFIGSCSSCGITGLAVHWYGDTADDFKSFVTKAASAASSNNLSELWITEFALNADVNGSADPSATAAFLNEVIPWLDEQSAVTRYSYFMCAENYLLSGSTLNLAGKAYVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W6QR27</accession>
    <name>W6QR27_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Probable transposable element</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S12g000030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792026">
        <property type="protein sequence ID" value="CDM38421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1365484.W6QR27"/>
    <dbReference type="OMA" id="DCHYSWR"/>
    <dbReference type="OrthoDB" id="4368687at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09276">
        <property type="entry name" value="Rnase_HI_RT_non_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481:SF1">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481">
        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14529">
        <property type="entry name" value="Exo_endo_phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="478"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="domain" description="RNase H type-1" evidence="2">
        <location>
            <begin position="949"/>
            <end position="1096"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM38421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="1306" mass="147625" checksum="BC9232836513E400" modified="2014-04-16" version="1">MEALINDPQSQDLDALLIQEPSITTYRTHVNHSAWRLYRPTTQTDAVRFRSLIYVNRRLSTSSHRQIPCDHPDVAAIKIWSADSQILLLSVYIPPAPLFMGDDESALPALTAIQNTITTTLHNEQRPTNIILSGDFNRHHPLWGGNHIPPRFIEQAGDLIEFLQSHNLHSCLPRGTATYWALNNPGQNSTIDLTVTDKPERLVKCHLYHENYGSDHRATYSEWDLQPQSKPNDKVRKAYERADWARIGEEVARKMSPWKDIKTRPTLDRVVEKLTSATAQAVDQFTPDTRPAPYSKRWFTPYLKVQQVEVNQLRRRWQASCAELGRDHASTTAAFQTMQSKRRAWTRTIEKAKASHWKQFLDEAGDGKLWKAATYMKPRETWGCTPALKVGSQELTQNKDKARAFLEAFFPAMNTSDPSLPASPQPELPWHPITTLEIERSLKTAKGTTAPGEDNLPMRVWKKLWVYLKPFITSIFRACIDLGHHPKPWRSAKIIVLRKPGKPDYAMPGAYRPISLLNTLGKLLEAVMARRLSYLAEKHGLLPSSQFGGRPGRTTEQALLVLSNAIDQAWYKHKVVTLIAFDLKGAFNGVNRVSLDASLQARGIPVVARKWIASFMSDRHANIGFDDFRTETELLVNAGLAQGSPLSPILFAFFNADLVDQPVDSHGGASAFIDDYFRWRVGRSAEENVAKIQAEDIPRIEEWAQRTGSCFAAEKTELIHLTRKRGEHPEGVTFNGAVVKPSPTAKLLGVTFDQGLRWKEHVQQAIKRATKATIALSGLRHLRPEQMRQLYQACVTPIIDYASTVWHDPLRDKTHLRHLNTVQRTALIRILSAFRTVATATLEVEAHILPTHLRLRHRAQRTIARLHTLPRDHPIWSALPRAQNRRNNIGSYARFPLAEALKTMDVDRLNELETIDPRPLPPWRKDAFVEIELEPDRERARDRAESAKDTSDIVVYSDASGREGHLGAAVVALDDNDEVVESQQIQVGPMERWSVHVAELIGIFYAVNMVYKLVHQRTNVVNGAHITATILCDSRSALQAIQNAKNRSGQRIVHAILQTATEVQAKNITLRLQWMPGHCENAGNDAADRRAKEAAEPGKTHPFRPLLSRENAFVRSKIYDQWGQEWKTSTKGAHLRKIDGDLPAQYTRKLYGNLPRNRAYLLTQLRTGHNWLSSYRKKIGYSDDDRCECGAQETVSHVLMECPKLRGLRAELRGKVGDALNSVSSLLGGSNEGEKGKPDTVSRAKTVQAVLDFAEASQRFRSRLDQELLFASPFRSRWPQTSPQWRLAFSPSDRGSHFGLSLAPHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W6QS92</accession>
    <name>W6QS92_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S02g002503</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QS92"/>
    <dbReference type="STRING" id="1365484.W6QS92"/>
    <dbReference type="OMA" id="MGLKENQ"/>
    <dbReference type="OrthoDB" id="428854at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="309"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="368"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM32352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="408" mass="43358" checksum="579C74E81C064678" modified="2014-04-16" version="1">MPGSNPFRVRNLGNPAAPLSTNPGTLAPVPSKPLSTPPIAPNGYPRKSSIPLEREVADSSSSDEDTNPFNLRVSASESEDKINAHKSPAPLEDDRQRDYSGSAPHLAPSTDGSPISPDHNMPSATGADSFYTGRHARSSIELDASPLGRARDKKPPPPPRSHHGRRIGSIATAESSQTARSRSTNRLSIPGSPGNLTLGTSHPSSVSLSSADYFSVTVATGSTDSLQRSQSQHKRPPTPPLSRRHSQMRRSKSTQSKITSRLNMSYDSESNDGSLPPSPDPSSRVENKRLSMPPPSSGDFQATAPLGNISLNLSPPTNSRPSSLKAGRRTSSYGSVSGPPPPPPPRRTRDSIARSSDVMGLKENQSPAPVPVPVPAPAPQPSNALDILADLTKLQKEVDDLRGHYENR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W6QTM4</accession>
    <name>W6QTM4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S06g000466</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792020">
        <property type="protein sequence ID" value="CDM37504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QTM4"/>
    <dbReference type="OrthoDB" id="4362247at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM37504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="66" mass="7241" checksum="9FDE8818F506C78E" modified="2014-04-16" version="1">MLIVIPHLSTRSPSRLGDVRAPDWATGLDKRGETVISEFRGTGFVGSAVRDGSRTRRGTVVSREWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W6QTW6</accession>
    <name>W6QTW6_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S06g000551</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792020">
        <property type="protein sequence ID" value="CDM37589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QTW6"/>
    <dbReference type="STRING" id="1365484.W6QTW6"/>
    <dbReference type="OMA" id="CLNVAIQ"/>
    <dbReference type="OrthoDB" id="5215637at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004882357" description="Mid2 domain-containing protein" evidence="2">
        <location>
            <begin position="26"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="211"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM37589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="284" mass="29988" checksum="C19FEAB838D28F09" modified="2014-04-16" version="1">MESYFRLKGLVLQLSLLSLFTAVFAVDQCYYPNGATSTDTPCYTDGDFSHCCANTSICLTNGLCLSMKQPFSLSRGGCTDSTWRSSRCTDICVKAQGGAGSAVVWLDGSENNATYCCNSVLVDPFSGEKICSNVDGATQTSFKILDGYIIPSAGVLSNFEEISNNTSSFVANGTDTAVTTAVTTAATTPVPTATATATASNENSCNESREIAIGAGVGVPLAAIALLSIGWAFWERRNRKLAALPAAQPTPLFQPSYQVARGHESYHAYELKGSPPKPAELYTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W6QUZ7</accession>
    <name>W6QUZ7_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S08g000010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792022">
        <property type="protein sequence ID" value="CDM37959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QUZ7"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="244"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM37959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="444" mass="49469" checksum="754C96106373F899" modified="2014-04-16" version="1">MEYADQFVKLSETLDATIMEWFAIFECTAMFETYSADDKSVWLPIRTAVDRARETEKHKRFEWSAVARLQQIGYGTTFAKQCAFLAARVVDWPQFCHWVNWVAFLRCTNGKQGQKRRPGVITGDITSAHDRLNELSMLDMPTDDIVPAMLRPEQGEEIGCVIDPHGLLIPRPVETRLIVPAAPVDPLPPPSPSASHPEAPPCPVASSCPASVGARNKSRATPEPSVMQQGTFSSLAGLDEQDGARQPGARQPGARRPGARISTLWVSFHRPWPPVLRGPPQITPGRICQLLGVDPDLEFPSRQKPTTIPQLLFGSFQHVSTSSDRRPVVLAMAQQEVNIYPSRRRTEGYPMGEGVQGSTKFTYGDMRVFGGCGACTARRANPHRLAARRDRSAWPLPIETSSRHHSTFHRFEPTMSTDNMIYYLMTSSSTPANFPDSFQRNEVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W6QW25</accession>
    <name>W6QW25_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S11g000012</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792025">
        <property type="protein sequence ID" value="CDM38309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QW25"/>
    <dbReference type="STRING" id="1365484.W6QW25"/>
    <dbReference type="OMA" id="AISEPWH"/>
    <dbReference type="OrthoDB" id="5979581at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM38309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="74" mass="8207" checksum="F61B213D3660900E" modified="2014-04-16" version="1">MSVPSLPDDLSDSDFGDVVSTENDELDLEAISEPWHKYDIKETPNVFYPVYLGEVLNERCLVEHKIGHGGGSTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W6QY42</accession>
    <name>W6QY42_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="5">K Homology domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PROQFM164_S03g001196</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QY42"/>
    <dbReference type="STRING" id="1365484.W6QY42"/>
    <dbReference type="OMA" id="MCFEMHG"/>
    <dbReference type="OrthoDB" id="271862at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22453">
        <property type="entry name" value="KH-I_MUG60_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056553">
        <property type="entry name" value="KH_Mug60-KHD4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10627:SF76">
        <property type="entry name" value="KH DOMAIN-CONTAINING PROTEIN YLL032C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10627">
        <property type="entry name" value="SCP160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24563">
        <property type="entry name" value="KH_Mug60-KHD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="269"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="567"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="654"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="763"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="848"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="910"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="767"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="851"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="981"/>
            <end position="995"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDM34472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="1004" mass="111325" checksum="43E65BDD9A82A780" modified="2014-04-16" version="1">MHKISNFTGQARHGWERMTPTFGMSRPHTDMAFRRPHGAPPMTPPTSIDPTVNLSFNVPFSSTLAGPDVEDVLHASPGALQRWTFPEGTLEGTSVHQLPVHTNNVEGLQRLCRKITEEKGGRVEATLTTSEAKAVPSLQRRPNGLVTNVCVTGDGDMARKMRARILNETPIMLRCATVDVDMHLIIDGSPKGIRASVLEHLDTLAAYTGADIFLLTPKLHDADSAVVSSYGYASDNGLEQRFRVAIYGDLESSEHAKTRVLIMIDQILKRHVDAIKLDSTMHTLVCGRTRKNIKLIEAATGTAIYFPPPFPQIFGYIPPGANRRSEDEVYITGETPEQIARAKQKLRELVMGVKIFVKDVVVSSSKIDNILLDRLDKVRKVMEMNGSYVLFPQLGSQRGLVRIQGTEVLHVERTVREIMALAGQFYSASWWIIMPDPAQGGLRAPSTADIRSMLSDICTNSEAEVSFDNLTFTINGSDDAVKAAMSVINQIPFVMRSQYQMRVKIELANEHKEFVSGKKNGKINKIMGQSNVQIIFDGFNEYNFYIDVCGNQYESTKNGLDLVEQEMPASISFHVPDQYHKRIIGIGGQHIQRIMKKYSVFVKFSNAMDRGGMGKEDDDIKVDNVICRTPARNAQSLDLVKQEIMDMVEKVDAEYVAERVVINRLYHRELLARMPEIEELEKKWNCKIEFPSTELASDVVTISGPEYQVPQAVDALLGMVPESHELHFQSSAELQEYFKCSDFLADVRTKLKEQYEVDINVDVGTDLPTTQEEGSSSPTPGPEDRVVLGYTRNNAGGLKDAIDFLISRLVAHGLDANTVKGAIPRPKSDSFEESLPFFDSKLLQHAPVPLSTDSPTRPNFSDESSERGSIFERLRKPGSISSFSSFIGRKNHSASPGSFFKHASSNASKASLVSMESRDSGYRNPWNDSGVNLPEDDVHVLGSSHSHKSSNSNGWPTRFDTKFPFGTAPGDMTPKHDPRTSYDSGRPSTSNSTSGYPAPIGPPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W6QZG4</accession>
    <name>W6QZG4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Genomic scaffold, ProqFM164S03</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S03g001674</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asteroid family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QZG4"/>
    <dbReference type="STRING" id="1365484.W6QZG4"/>
    <dbReference type="OMA" id="GEADDWC"/>
    <dbReference type="OrthoDB" id="5297549at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026832">
        <property type="entry name" value="Asteroid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039436">
        <property type="entry name" value="Asteroid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15665">
        <property type="entry name" value="ASTEROID PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15665:SF1">
        <property type="entry name" value="PROTEIN ASTEROID HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12813">
        <property type="entry name" value="XPG_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Asteroid" evidence="2">
        <location>
            <begin position="134"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM34947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="552" mass="62240" checksum="28D30B97F1556CD7" modified="2014-04-16" version="1">MGIPHLTRHLLPYAESVLLDGRAIDSELPHIQAVVIDGPSLVYHVYRRLLGWMDPSSDVLDYQPTCDEISRGVSSFLLQLTRMGVKIHKICFDELARRNLSLPATPKCRDVIPTERGQVWCSRGLPQRRKGLPENPFMVPAVFEDLLNRWSKEQIRKEVDDDISCLVTDVNHPWAEITVMVPGEADVECARVAKLTGCSVLTDDSDLLLHDLGQDGSLLFLDSVQTSSGVWDPAEPDIRGLRICPHSLSGRLGIPSVQWFAYELQKNAHLRFAELTRISQESSKATELSSEYLEFLQEYHDDTTDNAVIPGAEQSVQLLDPRVSELFWQYELPSIYCSDEQPHVYLGILNEDFSRRCAWEQGRTYRSLGYSFFNLSRLVVNRYAVVHEFVRRGGRIVAEEITLSGTKTVISDLDLLQKRLALAHATFDDGLAAESFWFLYALSDIYRDGSGTTTVPNAKGLESFLKNGYMARSTEWADIHLLAQMQAALYSLRILKQLLDIATPGLDLVDTSSLLADLPPLHIMMSRQKMTQSFANTRLVRHAVSKLIETYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>W6QZN3</accession>
    <name>W6QZN3_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AMP-dependent synthetase/ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S03g001754</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM35027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QZN3"/>
    <dbReference type="STRING" id="1365484.W6QZN3"/>
    <dbReference type="OMA" id="MPMFHAA"/>
    <dbReference type="OrthoDB" id="429813at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051414">
        <property type="entry name" value="Adenylate-forming_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439:SF2">
        <property type="entry name" value="ENZYME, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439">
        <property type="entry name" value="PHENYLACETATE-COENZYME A LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23562">
        <property type="entry name" value="AMP-binding_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="3">
        <location>
            <begin position="549"/>
            <end position="632"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM35027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="1040" mass="116381" checksum="380B22371EDCDABB" modified="2014-04-16" version="1">MESFRKRLLATTIDEQAETKPTQRFAVISQGLDLSNGLRDISIKDLAQAVNFMCWWIESIIGPAHSDSPETVAYMGGNDVRYLIFFLACQKTGYQAFLPSTRNSDEAYVHLLSAINCTKFFFGEERQERVLEIQGLVPKLDIFQAPTLNTILSDESGLRHYPYTKSYADAEDDIVCIIHSSGTTGMPKPVYLTNGFIMTFDSVTYLEKPPGRRPNTFHDLDQSQLLLAAAPFFHLMGLVTFIFSVWNECPMFVAPDKPLSVDYMIELLSTGHPTVALLPPSVLEDMSQSEKALASLKEVKKVYFAGAPLPLEIGEKLRKYTEIITVIGSSEAGVIPGLIPEDKTNWGYFEWNEDYGVEMQDTGGGVFELVIPRKKDSRDWKAVFHTYPELDAYPTNDLFTQHPTDPRLWKFCGRKDDVIVLSNGEKFNPIGMEGIIEGHPLVRKAVVVGQSRFQAGLLVDPSPAGWDMDPKVFIEEIWPVVQAANQTIAAHGRVMKNKIRLAVKTKPFQTTPKGNVRRRMVLQDYEEEIDMIYTEDLVDDLDQSLPQTLDHESLTEYIRQVITRVLEKPEIADDQDFYAAGLDSLMTIHASRILQKGIQLRRPDVEAGAINAQTIYGNPTVDRLSQSVMDILDGRAQADIPRAEKIKSLLEKYTSDLPVREVYRENGLPSPSTVILTGSTGSLGTYLLHDLLNSDSITKIYCLNRSDAEARQKKGFEEKGLHFDENDWKDKVEFLQVSFGEPQFGLDESKYQELLDSVDTIIHNAWKVDFNHSVDSFEGTHIRGVRRFIDFSLNSRNNAHVHFVSSISTVGAWTPDKGDLVPEVPIDDISVVLSQGYGESKHIAERICLEASQRSQVPTSVHRVGQIAGPTSARGQWNRQEWLPTIIATSKAMGKIPDQLGSVAVDWVPVDTLSNIIVEIVNTRHRDSSEARSAVFHLTNPEQTSWSTLIPAVQSEYAVEPVAFSRWLGELESITNPSSEEVASKPALKLLGFYRGLEGEGSALSVPLDVQRTKAASASMRALGAVSPSLMRNWLQQWQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W6R005</accession>
    <name>W6R005_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DNA-binding RFX-type winged-helix domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PROQFM164_S04g000028</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6R005"/>
    <dbReference type="STRING" id="1365484.W6R005"/>
    <dbReference type="OMA" id="DKYKFDS"/>
    <dbReference type="OrthoDB" id="338531at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016586">
        <property type="term" value="C:RSC-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052406">
        <property type="entry name" value="Chromatin_Remodeling_Comp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003150">
        <property type="entry name" value="DNA-bd_RFX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22970">
        <property type="entry name" value="AT-RICH INTERACTIVE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22970:SF14">
        <property type="entry name" value="AT-RICH INTERACTIVE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51526">
        <property type="entry name" value="RFX_DBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RFX-type winged-helix" evidence="6">
        <location>
            <begin position="459"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM35147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="742" mass="84922" checksum="298E55483010DFAE" modified="2014-04-16" version="1">MSASTPRTSLRQGLRHAPKINQPFIPDTAPARRSHTHHGLTSPQPPTSPHHVNMNPAANPQSAQFAVDSWEGKDNRQVPMSTREVPTPGNRPLMFSHVRDPSKMPRQLDYQDPYFPLRYLEVPRTDHIYKRAHYGLQSGIPDEVDFALYHLVQISNQRWDKFKFEGFPLLAETLMQKALDITQLCTGVKWEFQYDPRRPTDRANVLNSLHGTRDILDKISKIPVNLPDDSLETYDFNHRLRNIKEATLVLRNMVLLKENAFYVSRYANGLLRDFLVILINAPNQPRLNEIKNDALDIAEEVTKFLRTDPEDPLWISLVNCLDSPDRAHVVRSLWALTHFGTELDDADANRAMETLTRPTLQQMYYHTLLDLDKDILSGALDFWYQYTLSHDNIETLMDVVNFPIVFVPRMIALLTYEARPTKKETVLQEKKVAPPPTDIPRVSPELLEKLMELSEPERSSQWLRCCFIEDSECEITQIALWQAYQSRFADPRVTGGGVLPAAEFIKNVSNTFTNAQAQVINGPGTATKFIIKGIRPLETAHTFEGFPYSYCRWADNSKPSKMCQRAFTSPTDLRNHVFGDHMTLEPTDTPGQYKLDPAESPIHTCQWDHCTRFRASGPSANTSMVAGHVSSHLPEDRPADAQPTTAKRVVLQERIVRKWYYMDTPINEKGEPFGVAYKAALVLRNIARGLPNRTTSKYGGLPWKKACFTSQRPKIVEVWDRNRALRKELTELIMVIEKEVDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>W6R2W4</accession>
    <name>W6R2W4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Peptidase M3A/M3B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PROQFM164_S04g001043</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM164</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase M3 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM36162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6R2W4"/>
    <dbReference type="STRING" id="1365484.W6R2W4"/>
    <dbReference type="OrthoDB" id="534666at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006518">
        <property type="term" value="P:peptide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06455">
        <property type="entry name" value="M3A_TOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.390.10:FF:000074">
        <property type="entry name" value="Metalloprotease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.40">
        <property type="entry name" value="Endopeptidase. Chain P, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1370.10">
        <property type="entry name" value="Neurolysin, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024077">
        <property type="entry name" value="Neurolysin/TOP_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024080">
        <property type="entry name" value="Neurolysin/TOP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045090">
        <property type="entry name" value="Pept_M3A_M3B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001567">
        <property type="entry name" value="Pept_M3A_M3B_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804">
        <property type="entry name" value="PROTEASE M3 THIMET OLIGOPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804:SF84">
        <property type="entry name" value="SACCHAROLYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01432">
        <property type="entry name" value="Peptidase_M3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 7" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 7" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M3A/M3B catalytic" evidence="9">
        <location>
            <begin position="278"/>
            <end position="766"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDM36162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="771" mass="87719" checksum="0629C5366B44958E" modified="2014-04-16" version="1">MAPPLRVSFIFFGGIIFLTTALFYIWAEEFSTLSSELAKASAGEAISDSKNSTPFHEPSANVQCRPPQAPPSFLGTPSSIMEDIQYCIETSRELYNSLEQDVNETKATFENVLLPIANLENLCGLRYHIVGFYKSVTSNTYVHNASIESMKMIESFERQSCQHSGIFRLVSAVAQRGQTLLPEQQHFLDDRLRCFRQHGLHLNPSEQTKYNQIQTRLSELQYAYEENLKHPPPTLEFSRAELEGVSDEWLSIWKLESDSKGDNLFKIPLGRAEVSLVLRSATGSHTRERVYVANENKNHENAAIFAEIVNLRNDAARIAGFQNHADGALVGNMVRSFRDVDKLLWALKQDLNAAGQEEIAFLKEVKRIHLEEMSETFSDSYQLWDHHFYSRLQANKDAHTNIDALVSAYFPLEHVLRRVMQMVARLFGIRFEGITESKDRNGIVWHEDVRLFAVWDDSDAVNCTEPFLGYLYLDLFSRAGKFGGRVANFLLQPGFTFANGTRWYPVTAILSNFARPTISNQANLQFDDLIALFHEFGHAVHNLVSKTTFSRFHGTRVARDFVEIPSLLLESWCWEESILHSISSPSLLSPSTTRPTHNNNVNTSTSSISPFSLLQNFINAKRSHRVLSTLQQIHFATFDMAVHQIGDSEALNTTSISKLYNRLQRQVVGLNSSCVRDEKDDWGHGYANFGHLVSGYDARYYGYIYSRIYSVDIFQSYFQTNPLNHTPMRRFRHLALEKGGSQNENTTMAEFLGRQPDLRAFYRDLGISSGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>W6R5C3</accession>
    <name>W6R5C3_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Flavin prenyltransferase PAD1, mitochondrial</fullName>
            <ecNumber evidence="6">2.5.1.129</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">PAD1</name>
        <name evidence="9" type="ORF">PROQFM164_S05g000855</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for the ferulic acid decarboxylase FDC1. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>dimethylallyl phosphate + FMNH2 = prenylated FMNH2 + phosphate</text>
            <dbReference type="Rhea" id="RHEA:37743"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:87467"/>
            <dbReference type="ChEBI" id="CHEBI:88052"/>
            <dbReference type="EC" id="2.5.1.129"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6">Oligomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the UbiX/PAD1 family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.129" evidence="6"/>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM37022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6R5C3"/>
    <dbReference type="STRING" id="1365484.W6R5C3"/>
    <dbReference type="OMA" id="ERWEGWQ"/>
    <dbReference type="OrthoDB" id="5126881at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106141">
        <property type="term" value="F:flavin prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1950:FF:000001">
        <property type="entry name" value="Flavin prenyltransferase UbiX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1950">
        <property type="entry name" value="Flavin prenyltransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01984">
        <property type="entry name" value="ubiX_pad"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036551">
        <property type="entry name" value="Flavin_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003382">
        <property type="entry name" value="Flavoprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004507">
        <property type="entry name" value="UbiX-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004685">
        <property type="entry name" value="PRK06029.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00421">
        <property type="entry name" value="ubiX_pad"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43374">
        <property type="entry name" value="FLAVIN PRENYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43374:SF1">
        <property type="entry name" value="FLAVIN PRENYLTRANSFERASE PAD1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02441">
        <property type="entry name" value="Flavoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52507">
        <property type="entry name" value="Homo-oligomeric flavin-containing Cys decarboxylases, HFCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 6" id="KW-0288">FMN</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="1 6" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Flavoprotein" evidence="8">
        <location>
            <begin position="41"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="20"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="48"/>
            <end position="50"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="125"/>
            <end position="128"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>dimethylallyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:88052"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>dimethylallyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:88052"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00060793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM37022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="228" mass="25197" checksum="3386ABF9B7477453" modified="2014-04-16" version="1">MLSLLSGTKTLSSSRHSHGDSPTETAMPTIDQAPQQTRRRRIVVAMTGATGAILGIKALIALRRLNVETHLVMSKWAEATIKYETDYHPSNVKALADHVHNINDMAAPISSGSFKTDGMIVAPCSMKTLAAIHSGFCDDLISRTADVMLKERRKLVLVARETPLSDIHLRNMLEVSRAGAIIFPPVPAYYIRPASVDDLVDQSVGRMLDLFDLETGDFERWEGWQTQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>W6R7G5</accession>
    <name>W6R7G5_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GTP-binding nuclear protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">GSP1</name>
        <name evidence="9" type="ORF">PROQFM164_S07g000110</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the small GTPase superfamily. Ran family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792021">
        <property type="protein sequence ID" value="CDM37762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6R7G5"/>
    <dbReference type="STRING" id="1365484.W6R7G5"/>
    <dbReference type="OMA" id="FNAWDTA"/>
    <dbReference type="OrthoDB" id="48625at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000054">
        <property type="term" value="P:ribosomal subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00877">
        <property type="entry name" value="Ran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000131">
        <property type="entry name" value="GTP-binding nuclear protein Ran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002041">
        <property type="entry name" value="Ran_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24071:SF0">
        <property type="entry name" value="GTP-BINDING NUCLEAR PROTEIN RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24071">
        <property type="entry name" value="RAN GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00627">
        <property type="entry name" value="GTPRANTC4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51418">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM37762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="214" mass="24263" checksum="ADB4E0260A2B7D63" modified="2014-04-16" version="1">MAAETPTFKLVLVGDGGTGKTTFVKRHLTGEFEKKYIATLGVEVHPLNFNTNYGAIQFDVWDTAGQEKFGGLRDGYYINGQCGIIMFDVTSRITYKNVPNWHRDLVRVCENIPIVLTGNKVDVKERKVKAKTITFHRKKNLQYYDISAKSNYNFEKPFLWLARKLVGNPQLDFVAGIALAPPEVTVDEKQLEAYRKEMEEAANQPLPDEDDADL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W6R873</accession>
    <name>W6R873_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Proteasome assembly chaperone 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S08g000118</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792022">
        <property type="protein sequence ID" value="CDM38067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6R873"/>
    <dbReference type="OMA" id="VYVGCSI"/>
    <dbReference type="OrthoDB" id="5407417at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043248">
        <property type="term" value="P:proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032157">
        <property type="entry name" value="PAC4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16093">
        <property type="entry name" value="PAC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM38067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="157" mass="16893" checksum="3FC15C2F2153CEED" modified="2014-04-16" version="1">MATEAPPAVPSAELATPAVRPQELSFSLPRALHTTAHVHLTFLGNCATIFLATSSPGDSGGSIKPMGSFVYAMPDRTSPKSTISTTLYTSPSSIEYTTRISKILARRFSMPVYVGCSIDPHSMGLEVAEEIEGLTKIVDVITEKWEEHKQEKAGNAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W6PPW3</accession>
    <name>W6PPW3_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g000027</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PPW3"/>
    <dbReference type="STRING" id="1365484.W6PPW3"/>
    <dbReference type="OrthoDB" id="543156at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM26218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="70" mass="7813" checksum="997570C5FC341D24" modified="2014-04-16" version="1">MSSSSDRAPVRDQAEDDAWFPSPYSLSQYTSPKTDFNGANYPNLGLFPISVFTDIIWPLLSAVNYRAPIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2024-10-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W6PR95</accession>
    <name>W6PR95_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g000204</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PR95"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM26395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="100" mass="11536" checksum="6F3BA27930295480" modified="2014-04-16" version="1">MNLTISVPLRLAPKRELGPFLLDVSSSTFRKTKRERSYDKIENIRSSRERSRTGSEPRFYASAQASAKLAVINASPTPNTRIRIEFSGHFFYQVRRYTLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W6PRL4</accession>
    <name>W6PRL4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S01g000637</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PRL4"/>
    <dbReference type="STRING" id="1365484.W6PRL4"/>
    <dbReference type="OMA" id="WWRLSEI"/>
    <dbReference type="OrthoDB" id="4368470at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM26828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="278" mass="30803" checksum="30F3ADF70CADCF7B" modified="2014-04-16" version="1">MASPQDPPSDACKKLTISAKNFTEHASFAESVKGIICEAKHYQLLTVTDVPLGWEDFLWEADEDLPANRKTYDPITGLLRVSIMPTNGHDVASGWLSRAMVRWTRAGLTIPQEEDILYTMSDASIDFKYGVYRGWRKQPDAAFRIVGLNLPTLVVEVGWSEGYPDLLDDMNKLLVGGNGDIRAVIIIKFTQQGVNVSGFLEVYRLNSQGIPYLAQDETVFPTPQGQAAAQQQVRVTRSELFGKFLVPGMTGADILPLDVDWLRSICRSQIALMGLVPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W6PSL0</accession>
    <name>W6PSL0_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Dolichol-phosphate mannosyltransferase subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PROQFM164_S01g000540</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Stabilizer subunit of the dolichol-phosphate mannose (DPM) synthase complex; tethers catalytic subunit to the ER.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the dolichol-phosphate mannose (DPM) synthase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Endoplasmic reticulum membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the DPM3 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PSL0"/>
    <dbReference type="STRING" id="1365484.W6PSL0"/>
    <dbReference type="OMA" id="DCPEAYT"/>
    <dbReference type="OrthoDB" id="2014333at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033185">
        <property type="term" value="C:dolichol-phosphate-mannose synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013174">
        <property type="entry name" value="DPM3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16433">
        <property type="entry name" value="DOLICHOL-PHOSPHATE MANNOSYLTRANSFERASE SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16433:SF0">
        <property type="entry name" value="DOLICHOL-PHOSPHATE MANNOSYLTRANSFERASE SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08285">
        <property type="entry name" value="DPM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="40"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM26731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="92" mass="10232" checksum="D149EEB028CADD7C" modified="2014-04-16" version="1">MTRAVQTLSVLLLVSSLYLSLFLGLVPLNETVQTEVIPVLPFYALIVFACYLLARLGVAIFTFNDVPEAHAELQKEIELAKVELRQGKVEVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W6PT76</accession>
    <name>W6PT76_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S01g000765</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PT76"/>
    <dbReference type="STRING" id="1365484.W6PT76"/>
    <dbReference type="OMA" id="SKWTSEP"/>
    <dbReference type="OrthoDB" id="4094614at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005199">
        <property type="term" value="F:structural constituent of cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038843">
        <property type="entry name" value="Sed1/Spi1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35523">
        <property type="entry name" value="CELL WALL PROTEIN SED1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35523:SF1">
        <property type="entry name" value="CELL WALL PROTEIN SED1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004881052" evidence="2">
        <location>
            <begin position="18"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM26956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="191" mass="18388" checksum="BEAA87DB186CCA6A" modified="2014-04-16" version="1">MRFSIAALALGATGAMAGVVTETLTEYTTYCPEATSIVHGSHTYSISTPGYITMSHGPYTVTRPISTSTVTECNSCSSTAVVSTPVASAPVASAPAPSAPVVSTPLASSPVASSSTPLIPVVPSVVTSTPLVPTAGSTGVPSVPSSPSSAPSSPSSAVTPSQPAFNAGAMNAATGAGAGLAAILGAVALLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W6PUK0</accession>
    <name>W6PUK0_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PROQFM164_S01g001247</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the ZNF598/HEL2 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4"/>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PUK0"/>
    <dbReference type="STRING" id="1365484.W6PUK0"/>
    <dbReference type="OMA" id="VFTHEHT"/>
    <dbReference type="OrthoDB" id="3838338at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072344">
        <property type="term" value="P:rescue of stalled ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16615">
        <property type="entry name" value="RING-HC_ZNF598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057634">
        <property type="entry name" value="PAH_ZNF598/HEL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041888">
        <property type="entry name" value="RING-HC_ZNF598/HEL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056437">
        <property type="entry name" value="Znf-C2H2_ZNF598/HEL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044288">
        <property type="entry name" value="ZNF598/HEL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22938:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE ZNF598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22938">
        <property type="entry name" value="ZINC FINGER PROTEIN 598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23202">
        <property type="entry name" value="PAH_ZNF598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25447">
        <property type="entry name" value="RING_ZNF598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23230">
        <property type="entry name" value="zf-C2H2_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="14">
        <location>
            <begin position="102"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="369"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="421"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="598"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="61"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="421"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="436"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="454"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="609"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="650"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="666"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="735"/>
            <end position="747"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00035113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CDM27436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="771" mass="84603" checksum="240932498A2D36DE" modified="2014-04-16" version="1">MTDNQASTPESSSQGRGGRRRGRGGTAPSGRGDSQHNTGDGEKRPKPRTRGGGRGSGGDIGRQTRTTDRTNNQDTQPSKATTPAAKKPVEEATDDADDGEVCFICASAVEHTSVSPCNHRTCHICALRLRALYKNRACAHCRTESNFVIFTDDPVRRYEDFNKKDFARTDDNLGIEYESDEIFGDTVLLLRYNCPDEDCDVACLGWPDLHRHVKSKHNKVMCDLCTRNKKVFTHEHELFTTAELRKHERSGDDQPGAIDQSGFRGHPECGFCRQRFYGDDELYTHCRDKHERCHICDRRSSHRQQQYYIDYNALENHFHKDHFACLDKECLEKKFVVFESQMDLKAHQIEAHPDSLSKDIRRDARMVDLSEFDNMRTPYQQQRQRRGAGRGRDPNAEPLPVSSAQPMTRAEVAYQRQMAIQSSQSVSTRNFGGQLTRDDVQPVRAPERSAAATPVQSTSTSRSQPLPTAAFEGLNISANSAPATAQDQTRRMRHEAVIERASNLLRNDATKLAEFRSRVSSYRASSISATELIDAFFSLFDTSSTELGKLIKELAEIYEDASKRSDLLRAWNDWRAINEDYPALPAGGLLPGMSTGAVNSSGKRVLRLKSSTAKSSRSAVGRSGALPNAPSNPFPPLSASAGPSSRRGKPSAATPWAAAAPPPSFSRPAMPSPVSRPSSAAPSSSRTPTAPASRGADSFPALPAAAKPNVLMAGKTRGTVRWNDNRGPAPNAWGSAPSSGTASPAEPSNDDSSNGKKGKRNKGKQTLFHFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W6PVF7</accession>
    <name>W6PVF7_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Zinc finger, C2H2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S01g001696</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PVF7"/>
    <dbReference type="STRING" id="1365484.W6PVF7"/>
    <dbReference type="OMA" id="SGHPFTN"/>
    <dbReference type="OrthoDB" id="3524154at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057026">
        <property type="entry name" value="Znf-C2H2_ascomycetes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24537">
        <property type="entry name" value="zf-C2H2_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="531"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="658"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="50"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="74"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="158"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="199"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="236"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="293"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="307"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="363"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="396"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="658"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="679"/>
            <end position="697"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM27885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="697" mass="76083" checksum="AEC848DBE58FB546" modified="2014-04-16" version="1">MDLRFSQSSFYDFRQHRRHSERSQYAMPELTVSSHGPLPIAPRNRATMKPAPPPLPPPSRIPALEMGHDPGWQYANSQTPTSLPSINPGSSLFGGHRRPVTASQGDPMQIDELEGRQGAPLSRSPETQIQIQPPPSATDGFPNSMSIIPNPTGPVLSGEREFSLRSVKDSSNAYDQHLLSKIGKPQIAKPPSPGGSISLGDSRNSLSALTVPSRSPSNLPSPGPSEGSTLDVKWHNSPQSGGVSPRTNVNWREYVEGRSPSVESNAPSALDYDQGSFRRRYRGTTPQREDSISLPSRSNRGSYDQDVFSDIEGEFSADEPAPPRQFILREPTPPYPDSRQGMKRRASSPPREPISDDRHTLHIATSNGDLSQRRLSGHPFTNTLSVNPNYPASQRTLSTGSSLSIRTSGSYSSTLSIGGSSMTSLSPYDRPPPGGFSPSSDLDTFHEKSILNPSPPAALSHATLPRFPGPASLEPPATDSTGKMSVPTIMSLPKPATPKIGGLFICDCCPKKPKKFDSPDGLRAHEMEKQYACAYCNHRFKNKNEAERHQNSLHLRRHSWSCAALVTFQAAFHPSGAQACQTSAGAARDTCGYCGEEFPNFPQADWDQRFEHLTTVHKFGECNNAKKFFRADHFRQHLKHSHAGTSGKWTNILENACMKEEQPPEPREPRGPKDKAASGPQTGSLTTNAISEVISEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W6PVL0</accession>
    <name>W6PVL0_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g002059</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PVL0"/>
    <dbReference type="OMA" id="DAGSEQM"/>
    <dbReference type="OrthoDB" id="3050608at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM28248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="63" mass="6942" checksum="CC16E28697AC4149" modified="2014-04-16" version="1">MDKVSGIANKLGGNKGQEYIDKGIHTAEKKIVADKFDPEKKLSNAGHEQLDKARKSIPNKLTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W6PVW8</accession>
    <name>W6PVW8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PROQFM164_S01g001866</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PVW8"/>
    <dbReference type="STRING" id="1365484.W6PVW8"/>
    <dbReference type="OMA" id="IENPGVY"/>
    <dbReference type="OrthoDB" id="5411678at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549:SF30">
        <property type="entry name" value="MID2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="199"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="269"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="343"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="419"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="275"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="355"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM28055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="438" mass="44175" checksum="39FECD53D075ACD0" modified="2014-04-16" version="1">MATSVSKGAAAVATAIGSTAADTAVQTSAAAETTSETSAAQPTTSSADPTTSAVETTTSSTAAPTTSTEPTTSTTSSTTSTTSSTSTPEPTTSTPEPTTSTTTSTPDPTTSTTQPVTTSSTSTTSSTSSTTTAPTTSIAPETTTFSSTQGTTVVIITSTQLAPTADTTSITSSSATDSAALSTSTAAASSGGLSPSGTIAVAVVVPVVSVALIILALLFFWRKRKANKAAEEERRKEVEEYGFNPNNPNNDPTLPGMAGTVVPKDNESSGYRGWGTTSAGRKASTNLSSGMGGLAMSEGSSPGYHHGATPSDGTVQYSDGTRPDSGEIVEPLGVLGAAPVAANNRNNGDIHRGPSNASSAYSAANRSDASEESHMSAVHPSAGYYGENPYYGDINTHGAYGGDDYQPVIRDVQARRNTRIENPGVYPRQGNAGIAQNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W6PW78</accession>
    <name>W6PW78_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Calmodulin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">cdc4</name>
        <name evidence="4" type="ORF">PROQFM164_S01g001986</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PW78"/>
    <dbReference type="STRING" id="1365484.W6PW78"/>
    <dbReference type="OMA" id="HDQASTN"/>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903475">
        <property type="term" value="P:mitotic actomyosin contractile ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000001">
        <property type="entry name" value="Calmodulin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF0">
        <property type="entry name" value="CALMODULIN LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="72"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00020786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM28175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="139" mass="15344" checksum="CF648DC11543ED72" modified="2014-04-16" version="1">MASTNYKEAFSLFDRRGTGRVAGDLLGDLLRACGQNPTLAEISDLEKSVGGDFDFDSFLKVLNRPGGFREPGEPEEYCRGFQVFDKDMTGFIGVGQLRYILTNLGEKMSDDEVDELLKAVDTSSGEINYTDLVRTILAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>W6PWN7</accession>
    <name>W6PWN7_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Sulphonylurea receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PROQFM164_S01g002484</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PWN7"/>
    <dbReference type="STRING" id="1365484.W6PWN7"/>
    <dbReference type="OMA" id="DIQAGHF"/>
    <dbReference type="OrthoDB" id="422637at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005324">
        <property type="term" value="F:long-chain fatty acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015910">
        <property type="term" value="P:long-chain fatty acid import into peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007031">
        <property type="term" value="P:peroxisome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042760">
        <property type="term" value="P:very long-chain fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03223">
        <property type="entry name" value="ABCD_peroxisomal_ALDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050835">
        <property type="entry name" value="ABC_transporter_sub-D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11384">
        <property type="entry name" value="ATP-BINDING CASSETTE, SUB-FAMILY D MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11384:SF69">
        <property type="entry name" value="PEROXISOMAL LONG-CHAIN FATTY ACID IMPORT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06472">
        <property type="entry name" value="ABC_membrane_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="112"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="346"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="117"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="461"/>
            <end position="627"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDM28673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="644" mass="73331" checksum="AB038A743DE11DFB" modified="2014-04-16" version="1">MAAQSKLLPPERSIKQILSSLTSLYLRNRTNISRAVYLALFAALAKRIHNAISEQKAASQQVELLRRPGTSSLGDEEQPRKKRVGINREFFKNLLRLLKIVIPGWRSKELRLLVSHTVFLVLRTILSLYVAELDGRLVSNLVRGKGKDFLLGLVWWMIVAIPATFTNSMLSYHQCKLALSYRKRLTDYIHEKYLSNMTFYAISALDDRIKNPDQLVTVDVSRFSDSLAELYSNLAKPILDMAIYNYSLSKNVGGEGLFIMSLLVQLSANVMRMLTPPFGKYVADEARLEGEFRFLHSRLIEYNEEVALYHGHEAEKDTLDKGYFTLIKHVNRILRRRLYHGFMEDFVIKYFWGAMGLVLCSVPVFFKIPGQTTHSMADHTESFVTNRRMLLSSSDAFGRLMFSYKEISELAGYTSRVSSLLEVMDDLLAGRFEKKLVSSASTAENAEVLSGRGKVLESDAIEFIDVPIVSPNGDVLVRKLSFTVNPGDHLLIVGPNGCGKSSLFRILGGLWPVYGDRPGGWDAEEEWRDVLSGGLQQRIAMARLFYHRPKFAILDECTSSVTLEIEKVMYETAKKLGITLMTVSHRRSLWKYHQKILQFDGQGGYIFTGLDWERRLKLEDEKEELDLQLRAVPELERRVAELTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W6PWZ2</accession>
    <name>W6PWZ2_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">G-patch domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S01g002286</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PWZ2"/>
    <dbReference type="STRING" id="1365484.W6PWZ2"/>
    <dbReference type="OMA" id="MIQFVRK"/>
    <dbReference type="OrthoDB" id="20507at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011666">
        <property type="entry name" value="DUF1604"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13384">
        <property type="entry name" value="G PATCH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13384:SF19">
        <property type="entry name" value="G PATCH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07713">
        <property type="entry name" value="DUF1604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26093">
        <property type="entry name" value="HTH_TGH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G-patch" evidence="2">
        <location>
            <begin position="149"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="551"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="616"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="628"/>
            <end position="641"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM28475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="719" mass="77920" checksum="DAAF730D8A002164" modified="2014-04-16" version="1">MALKRTRAALEADLQAEQSPYAFYGTPLPPLDEGVRDDGSFVPIWKQELRDENGSKRLHGAFTGGFSAGYFNSVGSKEGWTPATFVSSRQNRAQKAEQKRPEDFMDADDLREQEESRQLQTSDEFAGFGTTELDATRRAGLMDILKTSGETMGVKLLKKMGWREGQGIGPKVRRKANLDESSAPGGDAEETYLFAPENPPMVAFIRKTDRKGLGFEGESRLESHNALPSIPDAEESDSFFGGRLAIQGKAQPPKPKESRRGGLGVGPLNDTGSDDEDPYSLGPQISYNKTIGGDKKKKKKAKPEPTIASSNPLLNSKPVFISKKVAASRGIGGFRKCRDGRLPLDGFILADGISGMSISEKKYDPPVIPEGWKPAKEIWSEKRDKSKYVSTADAAKASSLNPTSRAALLGEDQLPGKSIFDYMTPEAREKIAKLTGNANLPPALGEKAPKGYELPESKKRKDLWDLVPKLDKQTAAQALARAGGGWLPYQEDEKKRARYQIFLEVSAGTRSTLPERAEGSSTDDWVIEMQEFCRAAEVFKPISGVMASRFTSSSTAPKVVSDAPDSTESGLSRPAEKPDDPAVAAAKVGMFGPMTRSTIPFYPSRLLCKRFNVKPPENVQLDPERPGASSSGPGTRSQSAGFQAETGPKQLVSQDIMNQLLIDSLGYLPTADGLDPSGQPVSAAPPPVVIEPERNDALEAERPGDAVFKAIFGSDDEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W6PX37</accession>
    <name>W6PX37_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g002147</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PX37"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM28336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="65" mass="7309" checksum="06598534FCC44806" modified="2014-04-16" version="1">MGLSEPDSQATLTIGKEYPWRTGSSGSGPLDLSAERLFSLTLDRGMEYGRRWNPFYFGKDMTDQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W6PXM2</accession>
    <name>W6PXM2_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PROQFM164_S01g002789</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PXM2"/>
    <dbReference type="STRING" id="1365484.W6PXM2"/>
    <dbReference type="OMA" id="WGPRYQG"/>
    <dbReference type="OrthoDB" id="4505626at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549:SF33">
        <property type="entry name" value="MEMBRANE PROTEIN WSC4, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G09020)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013357042" evidence="6">
        <location>
            <begin position="16"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="158"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM28978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="272" mass="28300" checksum="700FE7655540652F" modified="2014-04-16" version="1">MIPLYALFLIPLVNGWTFRYTNATNATEIARGQDSQNCTNSPIGKEKLFTWDPEGSGLCVSIYRDLKCDSRAGYACEIWRKNASEAFAAFDVLPETEIDAKHQTSTLAVSTSTSATTSASASISTPSSVSSELVSAIPTGSTAVSTANSDSGFSDSSLSGGAIAGIVVGVVAAVAIIVAFVVIPIRKRNKKNTAVANQHGGYEPHEADATGSSISGTTAVVEKAADSAVRPFRPPPGSKIIELVGDEGSAELGSSPISEMDGNNIKKGFNRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W6PXP9</accession>
    <name>W6PXP9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PROQFM164_S01g002819</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PXP9"/>
    <dbReference type="OMA" id="GRHFAYI"/>
    <dbReference type="OrthoDB" id="5283415at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="148"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="236"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="50"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="365"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="403"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM29008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="417" mass="46136" checksum="2207B52C33B7E286" modified="2014-04-16" version="1">MTVPVDILAADAAGRIPSGVSLQYLAESRDRSAIVGIIFMVCFTGLLMIVRLYARVFIVKKTGLDDALAILTLMLYIAFVILSIVLINLGSGRHIEYIQYVLSLPTVRETEVLDFVAHILYTTALFLCRLSGLAFYFRLTARSSKLNLSIIIAAPLLLAAYLPQLFLLIFHCKPVTGLWPYEWQEEPKTYKCLSWGLVYSVNSGLSLACDMLMFVIPAVLIKGLHVSLEKKIKLSFVMFPGIFVIVISAIRVWLVAAGQWDSDGSWAYSPMLCVESAEIAGTLVALSVPAVKPVFGNLFAHMAEYTSSHTRSRSRSTKLHSLGHSKTIPSAAISTNRDSKRLINWSKIGMDDYEMMPSEVSVSRDILGGSRGSDRSEEARHKMHGSRSPGIRVTNEVNITRAQESEVRVETPRSRGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W6PY16</accession>
    <name>W6PY16_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein kinase-like domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S01g002666</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PY16"/>
    <dbReference type="STRING" id="1365484.W6PY16"/>
    <dbReference type="OMA" id="VRCTNCL"/>
    <dbReference type="OrthoDB" id="2906425at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05120">
        <property type="entry name" value="APH_ChoK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF58">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="2">
        <location>
            <begin position="169"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM28855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="390" mass="44545" checksum="A0E9E6F45171F546" modified="2014-04-16" version="1">MVEKGAFDLEGAQPANEARPASETQSVSEAVRFNARTLKKLQAALTKDPEVDLADQFPTQYLERLLRMRTTIESPKKPRYVEQDIRESLCPSDPVEIVFPLSDAVAKLLEPISQTAEGLPLSQRLFEVLKSSEIIYKAPFFHHKGVFKCSSEIVIKAVRYMEHNTQYTALQYLDRHKPNIPVPKPLGLVRMSGISLIFMSHMGSTTLREVWHTLDSDQKTSISNQLNTMLTDLRTLPFEEGTPLGGVAGEGCRDLRRHVRVSETPIFSLEDFETFLFLGPHPGGNVFIEFLRQLAPSFTNNSGPRIVFTHGDITPDNITVKLTDNKYVISGILDWEYSGFYPDYFESVRCTTCLRPYEEDDWFLYLPECVSPKIHAQWWLFDRVRQSRVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W6PY32</accession>
    <name>W6PY32_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein kinase-like domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g002691</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PY32"/>
    <dbReference type="STRING" id="1365484.W6PY32"/>
    <dbReference type="OMA" id="YAARRSW"/>
    <dbReference type="OrthoDB" id="5412996at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF37">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="77"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM28880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="468" mass="54195" checksum="5A7F62F79EAFBB0F" modified="2014-04-16" version="1">MLPLMKGKLMLFDEVAWDKSDEQLATWEAILLNQETMQKITTLIKIHRQGITDQLFPPQKGSFNMVIRLRFLDGASAIIRFPIPGYSVFPDEKLHREVRVMRFLERHTDIRIPHILHHGTSDESPHGLGPFIIMEYIDHNADLVDALNTPGILDEERPVLDPNIGDNRLRSVYNQMAGLLLQVAKYSFPRIGCISNAAEDEFEDEWVVAHRPLSINMNELVQVGGVRAGDLPGMTETFATTAEYLLALAELHMTHLSSQRNDAIDDAEDCRTKYIARCLFRKLAREGRLSWAGEEGMFKLFCDDLRPANVLANSDFGYKISGAIDWEFAYAAPLEFVYSPPCWLLLERPEYWDNGLDDWEWVYESRLEIFLQELHMREDVDIRRGVMSEENRLSRHMRESWNNGGFWVSYAARRSWAFDVIYWARIDRRFFGEGTLEDRIGLLTVEERNSMEDFVQRKLAEKEEGGLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W6PYE3</accession>
    <name>W6PYE3_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Dynein family light intermediate chain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PROQFM164_S01g003090</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PYE3"/>
    <dbReference type="STRING" id="1365484.W6PYE3"/>
    <dbReference type="OMA" id="KVNDHIG"/>
    <dbReference type="OrthoDB" id="27603at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035974">
        <property type="term" value="C:meiotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045504">
        <property type="term" value="F:dynein heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008467">
        <property type="entry name" value="Dynein1_light_intermed_chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022780">
        <property type="entry name" value="Dynein_light_int_chain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12688">
        <property type="entry name" value="DYNEIN LIGHT INTERMEDIATE CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12688:SF0">
        <property type="entry name" value="DYNEIN LIGHT INTERMEDIATE CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05783">
        <property type="entry name" value="DLIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0243">Dynein</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8" id="KW-0505">Motor protein</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="412"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="467"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="412"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="467"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDM29278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="516" mass="56984" checksum="C4F690062DF81876" modified="2014-04-16" version="1">MPSSPNPGKTSSRPTSKDGSKKNIWSSLLDTVANGKRLPEKNLLVLGGTPDSQREFLDTFSADTSADPSLVNDKRKGKGKTPPIANQFALGYTYRDVLDADKEDTLARVSAYLLSEPSPSFAPLLKPLLTPKSVPETLVVILMDWSDPWTWVRRLREWTRLLRSVLVSLDDETKFVMEETMTEWRDRKRGIDPSSAAAGGISTSSGPVTIPLGPGEWDEGLGIPMCVVCQGADKIEKLEKDHGWHEEQFDFVLQFLRTILLKHGASLIYTTPFLANSLQGLIHSSLGIHSLLKRESLKHNVIDRDKILVPANWDSWGKIRIIREGFDMEGVSTAWSIEIQESPESIYQSTDDNQQGENGVAEEGTSAVTMFELTINDPKRGTSNPHGNTTKIEVETTDLQEFFATQVEKLEDLKAKDEKENSNQPTPQLEMSPMADEGKVNDHIGPVQFNMGGIQVDADDMLKKLRDREASRTLKKESPYAGTAGNDEKAHNQALANFFAGLVKKPGSSPRGSPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q077</accession>
    <name>W6Q077_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S01g003502</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q077"/>
    <dbReference type="STRING" id="1365484.W6Q077"/>
    <dbReference type="OrthoDB" id="4369665at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM29690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="96" mass="10991" checksum="FB413A57D0BD397C" modified="2014-04-16" version="1">MDLLVALKIIVASQPTKRPFACFQELIFCLLCTVALEVTLKENVFQAMQSVFHCDANSKSLRGRIRGAKWANRAIYLLSRTNWGSRSWDIIYIENP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q0M7</accession>
    <name>W6Q0M7_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Deoxyhypusine synthase</fullName>
            <ecNumber evidence="6">2.5.1.46</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">dys-1</name>
        <name evidence="12" type="ORF">PROQFM164_S01g003643</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[eIF5A protein]-L-lysine + spermidine = [eIF5A protein]-deoxyhypusine + propane-1,3-diamine</text>
            <dbReference type="Rhea" id="RHEA:33299"/>
            <dbReference type="Rhea" id="RHEA-COMP:10143"/>
            <dbReference type="Rhea" id="RHEA-COMP:10144"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57484"/>
            <dbReference type="ChEBI" id="CHEBI:57834"/>
            <dbReference type="ChEBI" id="CHEBI:82657"/>
            <dbReference type="EC" id="2.5.1.46"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; eIF5A hypusination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the deoxyhypusine synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.46" evidence="6"/>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q0M7"/>
    <dbReference type="STRING" id="1365484.W6Q0M7"/>
    <dbReference type="OMA" id="HSIINAN"/>
    <dbReference type="OrthoDB" id="294378at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034038">
        <property type="term" value="F:deoxyhypusine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.910.10:FF:000003">
        <property type="entry name" value="Deoxyhypusine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.910.10">
        <property type="entry name" value="Deoxyhypusine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002773">
        <property type="entry name" value="Deoxyhypusine_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036982">
        <property type="entry name" value="Deoxyhypusine_synthase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00321">
        <property type="entry name" value="dhys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11703">
        <property type="entry name" value="DEOXYHYPUSINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11703:SF0">
        <property type="entry name" value="DEOXYHYPUSINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01916">
        <property type="entry name" value="DS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0386">Hypusine biosynthesis</keyword>
    <keyword evidence="9" id="KW-0520">NAD</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00020607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDM29830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="365" mass="39695" checksum="9BFD87993EE747A4" modified="2014-04-16" version="1">MSAQQPSIVPSSVTDSVLKSSQPVPEGSHIVSGVDFDKFQGRDITVAEMVDSLAHTGFQGSAVAEAAQIINEMRAFRDPETGNKTTIFLGYTSNLISSGLRDTLRYLVKHNHVSAIVTTAGGVEEDLIKCLAPTYLGSFSTPGAGLRAKGLNRIGNLLVPNNNYCAFEDWVVPILDKMLEEQEAAKIKARETGDEEDELHWTPSRITERLGREIDHEDSVLYWAARNGIPVFCPALTDGSLGDMLYFHTFKSSPQRLRVDIVDDVRRINTMAVRATRAGMIILGGGLVKHHIANACLMRNGAEHAVYVNTAQEFDGSDAGARPDEAVSWGKIKTDARSVKVYAEATAVFPMIVAASFARAESTQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q0V7</accession>
    <name>W6Q0V7_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S02g000084</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM29935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q0V7"/>
    <dbReference type="STRING" id="1365484.W6Q0V7"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM29935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="102" mass="11611" checksum="B11EB25493D1746F" modified="2014-04-16" version="1">MIACSDAKSLHCLLQSIHLDDAHRVNTRFNDALSAKAALRIEYWTWNQDMWCVLTSSPLLVYSHDLGLDACGGFIVIISDITSEKRAEYAYKQLAKDIQEHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q0X5</accession>
    <name>W6Q0X5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Membrane-associated, eicosanoid/glutathione metabolism (MAPEG) protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PROQFM164_S02g000109</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM29960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q0X5"/>
    <dbReference type="OMA" id="AYVFIES"/>
    <dbReference type="OrthoDB" id="2122304at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.550">
        <property type="entry name" value="Membrane associated eicosanoid/glutathione metabolism-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023352">
        <property type="entry name" value="MAPEG-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001129">
        <property type="entry name" value="Membr-assoc_MAPEG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35371">
        <property type="entry name" value="INNER MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35371:SF2">
        <property type="entry name" value="MAPEG FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01124">
        <property type="entry name" value="MAPEG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161084">
        <property type="entry name" value="MAPEG domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDM29960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="165" mass="18082" checksum="F41F3EEF6795636B" modified="2014-04-16" version="1">MSAFVTTLGLRAAPGQAPANHASALLMANWFFAYILTSPRGAKIRLGLDHNVSPREDLTTYGEAAVQSGKITRRALDKLKRQTSAHANVQEGYTLFVAAMLVSLYAGLPNETINTVGAWYSVSRVAYHLFYCNIESYSLSFLRSAAWWSGNISCLYALVQASKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q1M4</accession>
    <name>W6Q1M4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein kinase-like domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S02g000010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM29861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q1M4"/>
    <dbReference type="OMA" id="YGPMSRD"/>
    <dbReference type="OrthoDB" id="4177236at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF48">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM29861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="214" mass="24054" checksum="07D8327E8FA66ABB" modified="2014-04-16" version="1">MDNELQSIIELPTIADIEASTDVLSIRTNAIKVVRVKERFAVKIGYSIPPLEAENMKFVAANSKVPVPKVHANFIDPETQKRYVVMDFVPGTDLQKLLPSLTPTEKTTISQRIRQAINELRAIPSPGYFGNLNGTPYIDGVLSTPDNNPIISGPFKDQKQMNQGILERLGQMQSPHYIRLLKEMVNRTLKNHRIVFTHGDLQPKNIIVERKGVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q2H0</accession>
    <name>W6Q2H0_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S02g000330</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q2H0"/>
    <dbReference type="OMA" id="ANCSAQP"/>
    <dbReference type="OrthoDB" id="4366200at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="189"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="267"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM30181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="364" mass="39537" checksum="C905F14005B4CA1D" modified="2014-04-16" version="1">MALIDPNQPGFGLDQPDFGLDQPAFDPEAFLNSLTSLDANVSSNASNDFEHYQIPELLCSFDEFFASIPLDDLDQSGFGQSSSATSVNCFTQPLSSNIPAQAPYRQMPYDPSIGIAYTSEDTDASKVRSWENLIAQANLVNAGVPPSTPQIMEEETASQGLQTMDSPDSLFNSPGTQSVASVESVEIVETPSPTSSTPCPPRAPAATTTPSNAATNVIASAIPSPNPRAVQLPQALTNQKGYAQHVSPFAPVATIAPPISSMNSRELENARARIQTLARERNYYQRNLRKATNIDPKSGKTSLQLLQAENVNLRRANSKQSQEIQRMKNEAEAAKVSYATLAEYYNDSLKQLHKAELELEQLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q2M1</accession>
    <name>W6Q2M1_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Band 7 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PROQFM164_S02g000380</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the band 7/mec-2 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q2M1"/>
    <dbReference type="STRING" id="1365484.W6Q2M1"/>
    <dbReference type="OMA" id="YLQMLPK"/>
    <dbReference type="OrthoDB" id="434619at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08829">
        <property type="entry name" value="SPFH_paraslipin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.479.30:FF:000004">
        <property type="entry name" value="Putative membrane protease family, stomatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050710">
        <property type="entry name" value="Band7/mec-2_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032435">
        <property type="entry name" value="STML2-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001972">
        <property type="entry name" value="Stomatin_HflK_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43327">
        <property type="entry name" value="STOMATIN-LIKE PROTEIN 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43327:SF10">
        <property type="entry name" value="STOMATIN-LIKE PROTEIN 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16200">
        <property type="entry name" value="Band_7_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00721">
        <property type="entry name" value="STOMATIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="Band 7/SPFH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Band 7" evidence="5">
        <location>
            <begin position="82"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="379"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="388"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="405"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDM30231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="431" mass="46849" checksum="0C7555BA44776CB1" modified="2014-04-16" version="1">MEGASRQTSRLLRPRGQKLLPRLTRTSAVNATPFTHIQRRTLSNSPRPFAPESLLNTFRTGGSYNEGPTSYFSNRQTLPANTVVRFVPQQTAWIVERMGKFDRILEPGLAILVPFLDRIAYVKSLKEAAIEIPSQNAITADNVTLELDGVLYTRVFDAYKASYGVEDAEYAISQLAQTTMRSEIGQLTLDHVLKERANLNTNITKAINEAAQEWGVVCLRYEIRDIHAPEAVVAAMHRQVTAERSKRAEILESEGQRQSAINIAEGRKQSVILASEALRSEKVNHASGEAEAIKLKAEATALGIDAVARAIEEGGENAHSAVGLSVAEKYVAAWSNLAREGTAVVVPGNVGDMGGMIANAMAVYGKVSETHARGLAKKTLGVEDASRSSETSQNSQVPTFFEEQAGQNTQSNVASRTAEEGFETVAGEHKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q2P9</accession>
    <name>W6Q2P9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">3-dehydroshikimate dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">qa-4</name>
        <name evidence="2" type="ORF">PROQFM164_S02g000973</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q2P9"/>
    <dbReference type="STRING" id="1365484.W6Q2P9"/>
    <dbReference type="OMA" id="FMYEEDR"/>
    <dbReference type="OrthoDB" id="5360893at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.150">
        <property type="entry name" value="Divalent-metal-dependent TIM barrel enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050312">
        <property type="entry name" value="IolE/XylAMocC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12110:SF57">
        <property type="entry name" value="DIOXYGENASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12110">
        <property type="entry name" value="HYDROXYPYRUVATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="Xylose isomerase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylose isomerase-like TIM barrel" evidence="1">
        <location>
            <begin position="26"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM30823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="339" mass="38684" checksum="E1EE687E897AF514" modified="2014-04-16" version="1">MVYQPAIMSVSLGRPWLHDFEYKMGQASKAGFKGVELFYEDLDYFARGISKNDTPTSNQLLQAADKIHSICQAHSLEIITLQPFLFYEGLKDREQHAKLIEKMKLWLQLAKRLDTTTIQIPANFLPAEQLTDDIDVIVADLRQLADMGAAETPVIRYAYENLCWSTVNDTWEKVWDVVKRVDRPNFGMCLDTFNIAGKVWADPTSPTGKTANADSDLKESLERMVAEVDVAKVFYLQVVDAERLQSPLVPGHPFYVEGQPARMNWSRNARAYMYEEDRGVYLPVEDVARTITSGLGYKGWISMELFSRTMAEEGQHVPDQHAQRGIASWKKLQQRLQLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q2S4</accession>
    <name>W6Q2S4_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ASTRA-associated protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">asa1</name>
        <name evidence="9" type="ORF">PROQFM164_S02g001008</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Component of the ASTRA complex involved in chromatin remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the ASTRA chromatin remodeling machinery complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the WD repeat ASA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q2S4"/>
    <dbReference type="STRING" id="1365484.W6Q2S4"/>
    <dbReference type="OMA" id="WHKEGVY"/>
    <dbReference type="OrthoDB" id="7668193at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19854:SF1">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19854">
        <property type="entry name" value="TRANSDUCIN BETA-LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 7" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="18"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="425"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="371"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="372"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00037338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00037931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM30858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="440" mass="48159" checksum="2000A0E42B43A141" modified="2014-04-16" version="1">MDTKSVQAQSPATPVYILRGHASPIHALNIYSQNLRLVSGDANGWIVVWDLVTKRPVTGWKAHEGAILEARGFNVDLGATEIYTHGRDHKLCVWKLRPEDESFLDKTLPVDVAESAQPENKSQPWLLHSLPVNALNFCAFSIAFVNADGLPGAPSKSGKPENTLFAVPNALDSGGVDIFHLPSERRISTIPSDQSIQTGMLMAVNLFTSPSGDLYVASAYEDGHVMVFVHRGALKSASFEREYISSNPLKWDKLYAGHPHSQPVLSIDVAPSHRYFISSSADSLIVKHPIPSIGPAGYIPTPGYKEESPLKIVNTKHSGQQGLQIRSDGKVFATAGWDGRIRVYSAKTMKELAVLKWHKDGCYSVAFGDTESTSSLMSSSPESARQEPRDTDQGAAGQTVIDVRDYSLATVQQQRNQKVQETHWLAAGSKDGKISLWDIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q3J5</accession>
    <name>W6Q3J5_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Dolichyl-phosphate-mannose--protein mannosyltransferase</fullName>
            <ecNumber evidence="14">2.4.1.109</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">ogm4</name>
        <name evidence="17" type="ORF">PROQFM164_S02g001040</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = 3-O-(alpha-D-mannosyl)-L-seryl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17377"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:13546"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137321"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 14">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-threonyl-[protein] = 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53396"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:13547"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137323"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Endoplasmic reticulum membrane</location>
            <topology evidence="1 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the glycosyltransferase 39 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.109" evidence="14"/>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q3J5"/>
    <dbReference type="STRING" id="1365484.W6Q3J5"/>
    <dbReference type="OMA" id="NCHLNAP"/>
    <dbReference type="OrthoDB" id="292747at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004169">
        <property type="term" value="F:dolichyl-phosphate-mannose-protein mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd23285">
        <property type="entry name" value="beta-trefoil_MIR_PMT4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.80.10.50:FF:000044">
        <property type="entry name" value="Dolichyl-phosphate-mannose-protein mannosyltransferase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003342">
        <property type="entry name" value="ArnT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036300">
        <property type="entry name" value="MIR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016093">
        <property type="entry name" value="MIR_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027005">
        <property type="entry name" value="PMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032421">
        <property type="entry name" value="PMT_4TMC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050">
        <property type="entry name" value="DOLICHYL-PHOSPHATE-MANNOSE--PROTEIN MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050:SF51">
        <property type="entry name" value="PROTEIN O-MANNOSYL-TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02815">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02366">
        <property type="entry name" value="PMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16192">
        <property type="entry name" value="PMT_4TMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00472">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82109">
        <property type="entry name" value="MIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50919">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 14 17" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 14 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="42"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="126"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="235"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="272"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="591"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="633"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="727"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="16">
        <location>
            <begin position="323"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="16">
        <location>
            <begin position="392"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="16">
        <location>
            <begin position="457"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU367007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CDM30890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="776" mass="88601" checksum="74007F97FE5C4A1F" modified="2014-04-16" version="1">MSSPSPSLRKRGGKKDVYTALPSEDGPAPVSVPVKQKSEWDYWLAIVILTLLAFATRFYRLDFPNEVVFDEVHFGKFASYYLQRTYFFDVHPPFGKLLFALMGWLVGFDGRFLFENIGDSYIDNNVPYLSLRAMPATLGALTIPVVFLIMWESGYSLPACVLAAGLMVFDNAHVGEDRLILLDSTLVLSMALSILCYVRFYKLRHQPFSRKWWKWLLLTGFCMSCVISTKYVGFFTFVTIGAAVLVDLWNLLDINREQGALSMISWGKHFMARAVGLVIIPFMFYLFWFQVHFAILNRSGPGDDFMTPEFQETLSDNQMTAQSVGIQYFDTITMRHKDTKVFLHSHWDKYPLRYDDGRISSQGQQVTGYPHNDTNNQWQILPADPLIDPSESKSVRNGDIIQLRHVGTESYLLTHDVASPLFPTNQEFTTVSQELAEGERHNDTLFELKIESGKAAQEFRTLASLFKLIHVPTRVALWTHTTPLPEWGYKQAEINGNKNILQSSNAWYVENIENLEEDSPRLVKEERKVKTLPFLRKYFELQGAMFHHNNALTSSHPYATEPFQWPFLLRGVSFWTKNDTREQIYFLGNPIGWWIASSILAVFAGIVGADQLSLRRGVDALEEIWGPGTRSRLYNSTGFLFLCWAAHYFPFWLMGRQRFLHHYLPSHLASTMVCGALVEFIFNLQPLDPRTALPPVDDPSGKSKARSVSSLRRFITAKERMGCKSLIAGWIATLIILAATIWGFIFYAPLTYGTPGLDVAGVNARKWLNYDLHFAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q3R4</accession>
    <name>W6Q3R4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily domain, general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PROQFM164_S02g001135</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q3R4"/>
    <dbReference type="STRING" id="1365484.W6Q3R4"/>
    <dbReference type="OMA" id="WTLLDYP"/>
    <dbReference type="OrthoDB" id="2962993at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF38">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="38"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="75"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="130"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="259"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="291"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="324"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="349"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="198"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM30985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="376" mass="42659" checksum="D2203A3ED876CC09" modified="2014-04-16" version="1">MLWNVRIEQDRRQPFSFAPTCITIDVDAEKKLVRKIDLYLMPSVFILYLFSYMYQDRLNIGLAKIAGMKRICTSHQINTTLVWVIGYTISGVPSNIILSRTRLSVFLPVITFAWGSIAALIGAVRHQSQLIALRFLLGVFEAGFSIKAVHYLPNRRYTPRSIRGSNLRSYHIDIRWRTRYPWLEMALHCRRARNCRGKPDRPLDSTRLPHSSRGLSPEERKLSQQRLLEDGIADQGDSKDQNISIFVLLFKALSNWQTWVLIPGYMTISGAGAISYFYPTLIHEMGYTSTAAQYMTAPLYIASLAAAIPISWLADRKPHARAQLLMGDMIVGMVFFALIAGIRNNTARYLFLCFISMTFWTGSALALSFSPTSLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q3T2</accession>
    <name>W6Q3T2_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">DNA polymerase alpha subunit B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PROQFM164_S02g000781</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the DNA polymerase alpha subunit B family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q3T2"/>
    <dbReference type="STRING" id="1365484.W6Q3T2"/>
    <dbReference type="OMA" id="PFLDIEH"/>
    <dbReference type="OrthoDB" id="336885at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005658">
        <property type="term" value="C:alpha DNA polymerase:primase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.60:FF:000005">
        <property type="entry name" value="DNA polymerase alpha subunit B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.60:FF:000008">
        <property type="entry name" value="DNA polymerase alpha subunit B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007185">
        <property type="entry name" value="DNA_pol_a/d/e_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016722">
        <property type="entry name" value="DNA_pol_alpha_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054300">
        <property type="entry name" value="OB_DPOA2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23061">
        <property type="entry name" value="DNA POLYMERASE 2 ALPHA 70 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23061:SF12">
        <property type="entry name" value="DNA POLYMERASE ALPHA SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04042">
        <property type="entry name" value="DNA_pol_E_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22062">
        <property type="entry name" value="OB_DPOA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018300">
        <property type="entry name" value="DNA_pol_alph_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA polymerase alpha subunit B OB" evidence="9">
        <location>
            <begin position="227"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="DNA polymerase alpha/delta/epsilon subunit B" evidence="8">
        <location>
            <begin position="365"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="72"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="72"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="91"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR018300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF22062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDM30631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="657" mass="71771" checksum="E1D1C8E2E4122530" modified="2014-04-16" version="1">MDAEGELNEFFVGSFPDGIPKDILAELFSILRVHSITAEELFYKWESYSIKMGEGVTLTMQTVRGFKQDVQEALERESRDKAGRHTEKRTANTATPRGAAAAGGDMFGMFDQLTPTGSNARTGNGFGSAKRKAEFTSPATPKVSKFEKFGSQAGTKTPTGTPGDGMQAVSFSDRPNPGQTIETLNAHLSQPATPMAPFSEARIKPTANTDLKKLGYKPMGMKLSEASEILDDRIDEFATIFQAEFNSDDITFGSAAIQSTSEIIAVGRIASDSLEGKLNPASLVLETSRRTGAGRRVPLKVDSVPSVNFFPGQIVALRGINPSGEYFTVKEVLPIPLMPPAVSSAMVLDGINERLDGDANPPLNIMVAAGPYTADDNLDFEPLQELCQKAAENYADSLVLMGPFLDIEHPLLASGDFDLPDIKGLDPDTATMSLMFRHCISTSLARLAAAVPSITIVLVPSVRDVLSRHVSWPQEQLPRKDLGLPKQVRIVSNPATLSFNECVIGMCSHDVLSELRREEVLHGRPAEGNLLTRLPKYLIEQRHFFPLFPPTARSNLPKPGFEGGMATGAMLDIPYMKLGEWWNVRPDILIVPSMLPPFVKVVDSVLVINPGTLSKRRAAGSYAQMAVHPRLLAEDEREQKQLSHKLYERARVDIIRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q4L5</accession>
    <name>W6Q4L5_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">alcohol dehydrogenase (NADP(+))</fullName>
            <ecNumber evidence="9">1.1.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PROQFM164_S01g002936</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a primary alcohol + NADP(+) = an aldehyde + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15937"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15734"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:15938"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="10">
            <dbReference type="Rhea" id="RHEA:15939"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.2" evidence="9"/>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q4L5"/>
    <dbReference type="STRING" id="1365484.W6Q4L5"/>
    <dbReference type="OMA" id="ASRGTCI"/>
    <dbReference type="OrthoDB" id="1879366at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008106">
        <property type="term" value="F:alcohol dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006066">
        <property type="term" value="P:alcohol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05283">
        <property type="entry name" value="CAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000158">
        <property type="entry name" value="Zinc-binding alcohol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047109">
        <property type="entry name" value="CAD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42683">
        <property type="entry name" value="ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="12">
        <location>
            <begin position="17"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00050997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDM29124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="368" mass="39297" checksum="B660373D266AC0F7" modified="2014-04-16" version="1">MSPPTDQDTFKGWVAHDAKSPLTYTTYTPKPFTPTDVEISISHCGICGSDVHTLRSGWGPTDYPCVVGHEIIGTVTRLGSAVSSQSGPNAIRLGDRVGVGAQSGACLRADCDACADGEESYCARMTGTYNGRYSDKSKSYGGFAERWRGPAHFVFRIPDSLPSAEAAPLLCAGVTVFAPMRKYGVGPGKTVGIVGVGGLGHLGILFARALGADRVVAISRSSGKKADAVGGLGADGFIATGEEKGWAKKYSRSLDLILCTVSAHDMPFAQYLRLLKRDGTFVQIGAPEDALPPLMAWSLIQKSVKVTGSNIGSPDDIRAMLTLAAKKRVLPWIQKRDMVDVNQALVDMHEGKARYRYVLQNKSEQAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q4U5</accession>
    <name>W6Q4U5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Yippee-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PROQFM164_S01g003026</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the yippee family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q4U5"/>
    <dbReference type="STRING" id="1365484.W6Q4U5"/>
    <dbReference type="OMA" id="YLRCARC"/>
    <dbReference type="OrthoDB" id="6407410at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034751">
        <property type="entry name" value="Yippee"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004910">
        <property type="entry name" value="Yippee/Mis18/Cereblon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039058">
        <property type="entry name" value="Yippee_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13848">
        <property type="entry name" value="PROTEIN YIPPEE-LIKE CG15309-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03226">
        <property type="entry name" value="Yippee-Mis18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51792">
        <property type="entry name" value="YIPPEE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Yippee" evidence="4">
        <location>
            <begin position="48"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDM29214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="231" mass="25400" checksum="12BFA745A12BD88E" modified="2014-04-16" version="1">MSKERVKRLQFPKFLLPSVFSKQSAGLSPTDRIPQNTKTTKYLDGHVSYLCCAGCASHLCWTSQIISKGFTGRHGRAYLVSAEPVATAVSVSASSSPTASLPNTVLQRPVPRQLVTGAHTVSDITCTFCDSVLGWKYVAAEEESQRYKVGKFILETKKIAASSCWESSPGVDQTMKADRQYGIQSGPANTEFDSQDEDECEDLFAGIWSPGLAARRRNRQIKRRPAMWGIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q585</accession>
    <name>W6Q585_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Integral membrane protein sed5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">sed5</name>
        <name evidence="11" type="ORF">PROQFM164_S02g001954</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the syntaxin family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q585"/>
    <dbReference type="STRING" id="1365484.W6Q585"/>
    <dbReference type="OMA" id="EHNHNVV"/>
    <dbReference type="OrthoDB" id="421009at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048278">
        <property type="term" value="P:vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15844">
        <property type="entry name" value="SNARE_syntaxin5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.70:FF:000007">
        <property type="entry name" value="ER-golgi SNARE complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045242">
        <property type="entry name" value="Syntaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021538">
        <property type="entry name" value="Syntaxin-5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957:SF3">
        <property type="entry name" value="SYNTAXIN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05739">
        <property type="entry name" value="SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11416">
        <property type="entry name" value="Syntaxin-5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="328"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="10">
        <location>
            <begin position="257"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="178"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="216"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDM31803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="348" mass="38521" checksum="8E8F7F7ECC8C1810" modified="2014-04-16" version="1">MTGPSIQDRTSEFSAILGHAQKRLGTSKVGSQRQALLTDAQRRQANVSPQGPVQEAKAARSEFARRARDIGRGITGTMAKLQRLAELAKRKTLFDDRPVEISELTYVIKQDLAALNQNIASLQALTQAQHPKSNRSKTDQEGEHNDNVVVMLQGKLADVGASFKEVLEVRTKNIQASRTRTENFVSSVSSKSHSALDAQRSDSPLYNTAGRRTPQPGYQGNSSDLLTLEPSNPSPLGRPSFQSDQQLMVMEEGESSNTYVQARGEAIEAIERTISELGGIFGQLAQMVSEQSEMIQRIDANTEDVVDNVQGAQRELMKYWTRVSGNRWLIAKMFGILMIFFLLWVLIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q5H9</accession>
    <name>W6Q5H9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S02g002069</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q5H9"/>
    <dbReference type="OMA" id="TWRSDQN"/>
    <dbReference type="OrthoDB" id="4219928at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="383"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="185"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="266"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="390"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="461"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="496"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM31918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="698" mass="77229" checksum="B51D7DAEF364A70C" modified="2014-04-16" version="1">MDSGATDMPSHAWFPARIQTHIRNQGSNSSSLSHDTMAMAEPIPSPRRWSPTYTPRRRSRQMPSLSFVPSPVMPRIESHDFSNSQARRPTDRGPGCMSPFRSVRRMKEPFQLMLPTSPASLDGPPPNFPERPSKPYTAAAGRTLRTWRSDQNLNCGNLEGFGLLPSPPISESRPASTGPELSYFDAQSSDGSGRSSDGQDKSGTTKQEVSPTVATLEIGERIQYTAYRPPDWKNQPRTDVMNVHEAHSEFVRQCESSNERESYVQSPKKSAPSIASPKSMHSERVVVPGSSPRPQRPRTGTVSSEASWVPSNFSYCERWLQGVPVDKLDDQNTTTKEFTNRRKCQIVENDPPMPKLDIIPGAKALEEPVRFVVASKTKPKLVDIARQSSPSPPLIPPPCLLPNTVPTTPDQRQEEVSAFSPDTPLDMSDSGYGTRDSGFSFDSYDDSKVDHDDDDAYTDPGSLTSSDSVGSTVICEKPGSAQGERETSPQPEIRSGSVSPNASFLTTTHLPGPTSIISENEDEKPRIWHHDWSMDDHEWTLDELEHSVKDFPRHMLRLASPVMVFLRKNDEKTLIKPFRTIFPDVTENLIDCLCAALLARNYLLSLSTIHRNKPAIPPRKDVYAIDGVPKKAYTTLGIQLPSGSATKPKDPLFSSRSTELQGQLERIVDNLLFAICGRSDPTLKSAVEVLAQVLESTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q5K6</accession>
    <name>W6Q5K6_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S02g002114</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q5K6"/>
    <dbReference type="STRING" id="1365484.W6Q5K6"/>
    <dbReference type="OMA" id="GYFGGCV"/>
    <dbReference type="OrthoDB" id="3524679at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033481">
        <property type="entry name" value="Dni1/Fig1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12351">
        <property type="entry name" value="Fig1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="222"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="251"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="306"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM31963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="358" mass="38915" checksum="62611FD6D0993BC8" modified="2014-04-16" version="1">MENYSSSTLPRKKAKTGVKKTGVKKTGKKSTGKKKPTSSTSAVHLAAPYNPYPTNTQYAPNYAPLPQTVVIEKPIGGNRRGKKSICALVFLAVASYLLAISLGLYVLTSCAWTMADSNKIYLAELSTNTTYDISLRVGYFGGCLSVTDAAAVSSSDGNSSAQTFTNCVSNMRRKDLDDLSEELWEHLDHEVSSAQSDVQTFLNTTLPQFKHLQDDVFFCEPPLVHALLFFISGIMLLVARTGTSRKKSYKAMLVIAITFSAFSLALALVTVLGTLQGMNALLDASSSGEQRDLGDSLYLSRGKRMLGYQGALTGIVGVFYISMGVLFVQRTPEGAAGYVVQAWHTMGRPLRKGWGRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q5U6</accession>
    <name>W6Q5U6_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methylated-DNA--protein-cysteine methyltransferase</fullName>
            <ecNumber evidence="3">2.1.1.63</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">6-O-methylguanine-DNA methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">O-6-methylguanine-DNA-alkyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PROQFM164_S02g002214</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 4-O-methyl-thymidine in DNA + L-cysteinyl-[protein] = a thymidine in DNA + S-methyl-L-cysteinyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:53428"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:10132"/>
            <dbReference type="Rhea" id="RHEA-COMP:13555"/>
            <dbReference type="Rhea" id="RHEA-COMP:13556"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:82612"/>
            <dbReference type="ChEBI" id="CHEBI:137386"/>
            <dbReference type="ChEBI" id="CHEBI:137387"/>
            <dbReference type="EC" id="2.1.1.63"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a 6-O-methyl-2'-deoxyguanosine in DNA + L-cysteinyl-[protein] = S-methyl-L-cysteinyl-[protein] + a 2'-deoxyguanosine in DNA</text>
            <dbReference type="Rhea" id="RHEA:24000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:10132"/>
            <dbReference type="Rhea" id="RHEA-COMP:11367"/>
            <dbReference type="Rhea" id="RHEA-COMP:11368"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:82612"/>
            <dbReference type="ChEBI" id="CHEBI:85445"/>
            <dbReference type="ChEBI" id="CHEBI:85448"/>
            <dbReference type="EC" id="2.1.1.63"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MGMT family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.63" evidence="3"/>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q5U6"/>
    <dbReference type="STRING" id="1365484.W6Q5U6"/>
    <dbReference type="OMA" id="GGYKGSW"/>
    <dbReference type="OrthoDB" id="1907495at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003908">
        <property type="term" value="F:methylated-DNA-[protein]-cysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06445">
        <property type="entry name" value="ATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001497">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014048">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036217">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNAb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00589">
        <property type="entry name" value="ogt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10815">
        <property type="entry name" value="METHYLATED-DNA--PROTEIN-CYSTEINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10815:SF13">
        <property type="entry name" value="METHYLATED-DNA--PROTEIN-CYSTEINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01035">
        <property type="entry name" value="DNA_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46767">
        <property type="entry name" value="Methylated DNA-protein cysteine methyltransferase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00374">
        <property type="entry name" value="MGMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="14" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding" evidence="13">
        <location>
            <begin position="48"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDM32063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="158" mass="17392" checksum="71050CB01CEDB019" modified="2014-04-16" version="1">MSLSAQPADPTPDEQDPQPHNSPQPTLPTAQTKKYLHRISLHPTLTPYRRRVYRTLLSVPPGRWTTYSAMATYLGSSARAVGNAMRSNPFAPGVPCHRVLAADGSLGGYKGEWKVDRHKGGGGFCEEKRLRLEEEGVVFLDGKVRGVCFKEFVDLGAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q6Y2</accession>
    <name>W6Q6Y2_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S02g002266</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q6Y2"/>
    <dbReference type="STRING" id="1365484.W6Q6Y2"/>
    <dbReference type="OMA" id="LCEFAAP"/>
    <dbReference type="OrthoDB" id="4161595at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="352"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="441"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="505"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="590"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="624"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="222"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="373"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="634"/>
            <end position="644"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM32115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="644" mass="71881" checksum="9ABCD9EF4BBA23A4" modified="2014-04-16" version="1">MSTAMQGQGSDVHGHQGHLPEENVKIPSNNVHINQDALTPDSPNQTIHQENRALSLLLSPPPSSPLIPLGTIDSAPTQYSPEYPAGPQFTRMNGSYRVYNPIRGAELRTAADLANPFRDRLDQGGQMRDHGRARSRSPYSSIQSNGLLESQDLPAGPARGFNHYPREVYVPPGINDMMHLNLPSSSPTLFPDNTHSGGRDLALSLPGDSLGQSYHLNDGNWYGYPQEQQQQQVQGPERPPVAKQEEEDLDDNYEDHLCEFAAPCRMHPSPDGMHYRKVVSHVFGRNKAVTKLFPLGVWVHYCRKHYQRARYRADQWPFTQCDLLLESLTRMESWDGVESFELILRRREQMRVGREAEGTTTTETSKQKEVTSSGKAQDQGTKSSAIVTRPGRRHPTAIIAPVPDWLRQHVGHGKTFQEIRQIIEMVRSHMVRLRNQERAQQQLNDVPKSPGKPGSLRRGASSSIRKGRTAKGQSPLPLRPSTVRFPDVEILPHFKPWVKEAALRQRSATNGPMNMNMNEPEIKDESEQRILGGGRVLGEIQDNRDTNGAGSSQASNGDFAATAAQHCEGRLESVTAVSADDTAGVNLLQVQPHIGRAGTNRGQSESQRRRSERVYIKALDRLPGQSLNKKTIKEDEEEEAENEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q790</accession>
    <name>W6Q790_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Serine-threonine/tyrosine-protein kinase catalytic domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S02g001982</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q790"/>
    <dbReference type="STRING" id="1365484.W6Q790"/>
    <dbReference type="OMA" id="EYKSHEV"/>
    <dbReference type="OrthoDB" id="1668230at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050167">
        <property type="entry name" value="Ser_Thr_protein_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23257">
        <property type="entry name" value="SERINE-THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM31831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="263" mass="28891" checksum="F7E23F1A0551D06D" modified="2014-04-16" version="1">MGFFSTSNRADSFIAAGTTSTIYAVDENFVIKLRPSSGDFQRQAYDTEVRSYKRLGHHGHIASCEVNEEGLLLERGICLRTILQSAGSTSDGPSKARESPISLATKLQWAQEAADGLAYIHSKGIVHADIGCHNMTVDNSNHVKFIDFAGSGIDSEAPLVCYEWFSFQPGKEIGVCTDIFAFGSMLFELETGRVPYSELEGTMEMGNLITVVENLFAQRQFPSVETLALGSVISACWNGKYNSMEEVHRDIACQSKNYSEKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2024-10-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q7P6</accession>
    <name>W6Q7P6_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S02g002182</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q7P6"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM32031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="98" mass="11073" checksum="65CF51AFAD2C4655" modified="2014-04-16" version="1">MAAKHLIGLKPRNFKVPKTTLNSTNFQHSCSRQIDLKPDGASIIDIESLIDANRTRDMDKLRANSTELYQSSEDGLSIYSLTVRGFNFQKTFFESSDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q7T5</accession>
    <name>W6Q7T5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative formamidase C869.04</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S02g002227</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q7T5"/>
    <dbReference type="STRING" id="1365484.W6Q7T5"/>
    <dbReference type="OMA" id="ATWNKRE"/>
    <dbReference type="OrthoDB" id="9975579at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.580">
        <property type="entry name" value="Acetamidase/Formamidase-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004304">
        <property type="entry name" value="FmdA_AmdA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054833">
        <property type="entry name" value="FormamaseFmdA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF045496">
        <property type="entry name" value="FormamaseFmdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31891">
        <property type="entry name" value="FORMAMIDASE C869.04-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31891:SF1">
        <property type="entry name" value="FORMAMIDASE C869.04-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03069">
        <property type="entry name" value="FmdA_AmdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141130">
        <property type="entry name" value="Acetamidase/Formamidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM32076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="412" mass="45125" checksum="9BFA252B68AD5E68" modified="2014-04-16" version="1">MGIKGIRTALKVDLDKPAWEQPGLHNRWHPDVPAHGKIANNEVVKIECLDWTGGQIGNNDSADDIRNVDLTQIHYLSGPFDIETAEPGDVLLVEIQDVQPFEDQPWGFTGIFHKENGGGFLDRLYPEAAKAIWDFEGIFCSSRHIPHVRFAGLIHPGILGCAPSAEVLAEWNRREGELIAANTIADQIVAQPPNPQNAHAGSAIDDAKSKIANEGARTIPGRPEHGGNCDIKNLSRGSKVYLPVHVPGAKFSVGDLHFSQGDGEISFCGAIEMAGVITLKFTVIKDGMAKLAMKSPIFHAGPVEPQFGPGRYLTFEGFSVDEHGKQHFLDATVAYRQTCLRVMEYLRRYGYSDYQIYLLLSCAPVQGHIAGIVDIPNACTTLSVPMDIFDFDIRPEADVVKLEMGTCAFESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q892</accession>
    <name>W6Q892_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Quinate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">qutB</name>
        <name evidence="2" type="ORF">PROQFM164_S02g000608</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q892"/>
    <dbReference type="STRING" id="1365484.W6Q892"/>
    <dbReference type="OMA" id="AIYVMRR"/>
    <dbReference type="OrthoDB" id="204377at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004764">
        <property type="term" value="F:shikimate 3-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019632">
        <property type="term" value="P:shikimate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01065">
        <property type="entry name" value="NAD_bind_Shikimate_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10860:FF:000030">
        <property type="entry name" value="Quinate 5-dehydrogenase QutB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10860">
        <property type="entry name" value="Leucine Dehydrogenase, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013708">
        <property type="entry name" value="Shikimate_DH-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022893">
        <property type="entry name" value="Shikimate_DH_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21089:SF1">
        <property type="entry name" value="BIFUNCTIONAL 3-DEHYDROQUINATE DEHYDRATASE_SHIKIMATE DEHYDROGENASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21089">
        <property type="entry name" value="SHIKIMATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08501">
        <property type="entry name" value="Shikimate_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Shikimate dehydrogenase substrate binding N-terminal" evidence="1">
        <location>
            <begin position="27"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM30459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="351" mass="38121" checksum="6D0ACA7AFC99662F" modified="2014-04-16" version="1">MSVTEINQTQLEEPIAIPSNRDGVAYLYGHPLLNSLSPPLHQTVYNALGLNWTQIPLSSVSGSSETYPPPYTRSPPIEKYLASIKSNPKFVGSSVTMPHKVAIMPYLDDLTEHARQAGACNTIFLREDPTTGQRQYVGTNTDCDGIREALTQNAPDPTRFRGRPALIIGGGGTARTAIYVMRRWLGSSRIYIVNRDAAEVAAILEEDRRRNPDPNAQAPLIPVTDPAEAARLESPAAIVSGIPNYPPKSPEELRSRAIIQAFLGTAAGAEKQQGVILEMCYHPTPWTEIAHLASVGGWKVILGSEALIWQGLEQARLWTGKDVIGTPGLVQEVKDLVSKTIAERGSAKSTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q9R0</accession>
    <name>W6Q9R0_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Galactose-binding domain-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S02g001079</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q9R0"/>
    <dbReference type="STRING" id="1365484.W6Q9R0"/>
    <dbReference type="OMA" id="CHIAAYL"/>
    <dbReference type="OrthoDB" id="4240053at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003305">
        <property type="entry name" value="CenC_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02018">
        <property type="entry name" value="CBM_4_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBM-cenC" evidence="2">
        <location>
            <begin position="7"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM30929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="164" mass="17578" checksum="2E09266952EB1224" modified="2014-04-16" version="1">MALSACNAVSNPSFETGILAPWHPSAVNVAQVSNGTIAYSGDYYLNLQTAVGNRGNTISQGLRHLKPHTEYKFSAQAQVPSPSGSEYCSVYVYVGRNATVGSIASVQLFNFGEWTEVTGSYVPKRENEILSIGAACDSEDSSYTDNVLFDDISFIPNDCAYGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W6QA17</accession>
    <name>W6QA17_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="10">AAA+ ATPase domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PROQFM164_S02g001174</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QA17"/>
    <dbReference type="STRING" id="1365484.W6QA17"/>
    <dbReference type="OMA" id="KPVIFME"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042626">
        <property type="term" value="F:ATPase-coupled transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF269">
        <property type="entry name" value="ABC MULTIDRUG TRANSPORTER (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="60"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="174"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="402"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="423"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDM31024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="461" mass="50795" checksum="5C0391B968455A4D" modified="2014-04-16" version="1">MRQKQKAWVHAVQERVNFTSIMLKELRQIKMFGIESDVAFKTNGLRELELHQSKPYRSMIVGVNVLSALSTAIAPALTIAMYATTQLNLRLETPSTDVAFTNLSLISLLTNPVVLLSVSLTRFTSAIGCFDRIQEFFCKKNRVHGLSSVDEYLLPENVLGMEPESVPTQSQPLVCMTDCCFSLGLEAPAILHGLTLKIQNGFFLAVTAPLGSGKSSLLKDMLGEMHSTEGILTVRSVKQAYCQQAPWIFNGTLRTNTIGESPLDETWFKEVVYVCNLDFETTTLSLGLDTLTGSSGAELSGGQKQRVALARAIYARSSLLILDDIFGALDTVTSRLIFQRLLDRAGLVRRLGIATILVTTAVEHLKEADNLIVLSKDGRMECQGLFEELAKKNQYIQSLLCSPSPEDSEVEEESKDSNSQVGEIREEKKETRQTTQTKTVSKISRVMGTPHSTRLVGGHVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W6QA65</accession>
    <name>W6QA65_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Altered inheritance of mitochondria protein 31, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">aim31</name>
        <name evidence="12" type="ORF">PROQFM164_S01g000491</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Cytochrome c oxidase subunit which plays a role in assembly of respiratory supercomplexes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Associates with the respiratory chain complex III/complex IV supercomplex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RCF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QA65"/>
    <dbReference type="STRING" id="1365484.W6QA65"/>
    <dbReference type="OMA" id="YYRTERT"/>
    <dbReference type="OrthoDB" id="6604018at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097250">
        <property type="term" value="P:mitochondrial respirasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007667">
        <property type="entry name" value="Hypoxia_induced_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050355">
        <property type="entry name" value="RCF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12297:SF3">
        <property type="entry name" value="HIG1 DOMAIN FAMILY MEMBER 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12297">
        <property type="entry name" value="HYPOXIA-INDUCBILE GENE 1 HIG1 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04588">
        <property type="entry name" value="HIG_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51503">
        <property type="entry name" value="HIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="70"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="HIG1" evidence="11">
        <location>
            <begin position="7"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="131"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="131"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDM26682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="179" mass="20688" checksum="0068D7C91D08EE79" modified="2014-04-16" version="1">MNREPVPSSFDEENPQFTEETGVQKFKRRLKEEPLVPLGCAATCYALYRAYRSMKIGDSVEMNRMFRARIYAQAFTLVALVAGGMYFKTERQQRREFDQAVELRKKQEKRDAWLRELEIRDKEDREWRERHAAIDAAAKEAGNKPAPRSESEAARSSIEPADEKSIGVMDAVRALISRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>W6QAR7</accession>
    <name>W6QAR7_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Signal transduction histidine kinase-related protein, C-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PROQFM164_S02g003288</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM33136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QAR7"/>
    <dbReference type="STRING" id="1365484.W6QAR7"/>
    <dbReference type="OMA" id="KHGLWED"/>
    <dbReference type="OrthoDB" id="303614at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.130:FF:000023">
        <property type="entry name" value="Sensor histidine kinase/response regulator, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050956">
        <property type="entry name" value="2C_system_His_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43719:SF11">
        <property type="entry name" value="HISTIDINE KINASE_RESPONSE REGULATOR, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43719">
        <property type="entry name" value="TWO-COMPONENT HISTIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="6">
        <location>
            <begin position="375"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="7">
        <location>
            <begin position="844"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="803"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="817"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="4">
        <location>
            <position position="895"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM33136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="964" mass="105800" checksum="4B33B405800BE0B3" modified="2014-04-16" version="1">MRFYAEVPLFSASGHVLGSYCVVDDKPRDVFGDHEVALLQEIADAIAHHLENARIVHFHRRAEKLVKGVADFVTDHPNPDAELKKPTATFSGLPLHTQSANDGESGLSPSMQAARVLESTTIAEEISALSFSTERSDQTRITSVPSSFEGQIAAMTPLNENHTTRDRVSSHFRTSRIKPGVAISQSIASIFSHASAILRDSMDLAGVMFLDAYQSNSGVKPFQHNGRSSEVSESLCESFGHALGISEHRSPDDSGVAVTEKLLRIMIDAYPEGQIFNMSDQFEDNEPAELEASNDITQTLAAQFPDADSVLFLPLWDWNKSRWLAGTLVWTKLPQRALGSEELGFFKAFGNSIISEVARVNWDAIEKSKSDFISSISHELRSPLHGVLGNTELLRATALEPVQVDMVKLIESCGLTLLDVLDHLLDFTKINSIQREDSLMADMTTLMTDVDLGILIEDVTGIMYSSQTTGDRQSFQSNVEGLLTPAIPSTNARDMENLNVVIRIEEKTPWKVRTVAGAWRRILMSLVGNSMKWTRKGVIEVSLSNISPNSDSEPVLAHLSVTDTGRGISPEYLRHSVFSPFSQEESLSEGIGLGLSLVHKLVTFLGGHIDVESEMGMGTQIDIYIPVQSLTAESSESLDPYSKPAVPIPPTRVCLIGFEGYPDLQETPTGIQSTESKRKLSIQKAVGEVLLAQPNLSVSFSESVENAQGDFAVIEEAKLLQTLQDGSLFSVQTRFKSFLVLGEKLSIAEGNFKANLVRVSQPYGPQKLRKAVNSILADLELSETHQDPYPKCDTAFVQEALQSNDHDARRNTRPKSGMSNTAAQTPAPTLPVTLEPPIIDDRAHVLIVDDNDINLKILTTFVQKLGCSYESATNGLIALGRYKESKHRINYVLMDLSMPVMDGLTATTKIREYEKENNIPEACIMAVTGVASAEMQQQAQLAGIDDYVVKPVSLQTLRKMMNIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W6QBL8</accession>
    <name>W6QBL8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Cation transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PROQFM164_S02g001704</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TrkH potassium transport family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QBL8"/>
    <dbReference type="STRING" id="1365484.W6QBL8"/>
    <dbReference type="OMA" id="NNHPRDV"/>
    <dbReference type="OrthoDB" id="9999863at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140107">
        <property type="term" value="F:high-affinity potassium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030007">
        <property type="term" value="P:intracellular potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003445">
        <property type="entry name" value="Cat_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004773">
        <property type="entry name" value="K/Na_transp_Trk1/HKT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015958">
        <property type="entry name" value="Trk1_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051143">
        <property type="entry name" value="TrkH_K-transport"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00934">
        <property type="entry name" value="2a38euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31064">
        <property type="entry name" value="POTASSIUM TRANSPORT PROTEIN DDB_G0292412-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31064:SF37">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02386">
        <property type="entry name" value="TrkH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002450">
        <property type="entry name" value="K+_transpter_TRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0630">Potassium</keyword>
    <keyword evidence="4" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="32"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="284"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="327"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="358"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="423"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="463"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="486"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="571"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="595"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="125"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="173"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDM31554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="692" mass="77194" checksum="105B69360A3FBC55" modified="2014-04-16" version="1">MHVLVTLRKWRRKTGSAIMAVLPPLNFLTLHYSYFIATCIIASIIFYLTSSPWRSVAYVDSIFMCVSAMTGAGLNTVDLSTLNSFQQAVLFTMLILGHAILISLTVLLVRKRAFEAKFKGVSDEREKERSSRNLSEVELQARDRDPAHASSGIDLLDESIEGHGCKPRPKTTVLVQTTPGEPSSRNEQIWVDDDQITVGGTPRHHHHRVFPMAGIGARPDLHNHPRDAAPNVPLVVKDSVSGLKGILRGTQKYIASKGLVSRNSQFHDLTPAEREELGGVEYKAVSLLSVVVFLYFILFIVFGMVGVGGWLEANDPAVTRTNGLSPFWTGAFFAVSAFVNSGMSLLDANMTALQLRAYPLLTMGFLILAGNTLFPCFLRFIIWTMRVMLPDRPMWQSWRITLDFILEHPRRVYTNLFPARHTWYLLGTIIILNGIDWAAFELLSIGNKDIETLPTEYRVLDGLFQALAVRAGGFYVVTIADLRQGLLVLYVLMMYVSAYPVTLTMRNTNVYEERSLGIYAHDESPDSPANTSRSNVVMDLIRQHLGRPGPSETSRGYFLHQQLRSQLSHDLWWIALAVFFIAIAESDHYNNQPVAFSTFNIIFEVVSAYGCVGVSLGFPGKNYSFCGAWHTISKLILAAVALRGRHRGLPVAIDKAIMLPSESLAWAEEEDAAMRRDRSRAWAQENGPVGSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2024-10-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>W6QCC3</accession>
    <name>W6QCC3_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S01g001071</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QCC3"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM27262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="85" mass="9493" checksum="9F9F3C99A143C715" modified="2014-04-16" version="1">MCSALNPNWEAVKTPLEDCTSASVPNPGMTRFRRSFSRVAMEKNGASEKGRSQRDSTSPFWATSPEPWNHSYACAAYTLVRLLHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W6QD59</accession>
    <name>W6QD59_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S03</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S03g001352</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QD59"/>
    <dbReference type="STRING" id="1365484.W6QD59"/>
    <dbReference type="OMA" id="NGREHMK"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM34628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="746" mass="85094" checksum="4F53F3EA7134B2C8" modified="2014-04-16" version="1">MSFGRHVYRHALKPPATPTLEHPWISDDLLAATFRRFANGQRRHGSCVPGPLEARRRLAKRRNTALASIGGGPAEDIACLFGRNGREHMKWTDHPWQRAPFETQSLADHSLGPLELPFSFSDQNPAPGPHSTHGPPSYIANADQVTREQMLEAFLDGKNWGIEDVRDFTRRLRIDLHREPRYSRQIFERLLARSDPDLTEAIAFLDDPFLNTRGSGNYAAAVEIFVRTKTKRGKRTAVLNAINRALELGLISTDEICLIITALPNIIVERNKTLGSWDHKALLKHYRAMWKAIGCCNILGYHDLDRNIVDAWLEVLLRTRSFRFAEELIIETHDAESRSQWPTALVQAWLESMEVDSETSLPFPDKIFSQLDVNSAADCVIRVTESLASSSADRDSRNQLLERWRDCLSNAEVISTVAKSQVWFDFPLPCVQTQIKHAPLSHSTQRQIILRLWLLRTLGRSTGPMYSKSSRATDQPICSLLNLYETLIQGTSGIFFPDFMREIHDLDLPYNSLLILALNKKGKNSITKTTRKTLEQLETCQLSLAEVWTNPSIYKGIQGLFHSTFDQMFHCMDLTSPATVEELLSVVRSGDSKSIWPILRLLNNNTPFKISLHKAWQPIPHPDDKVLVRYHPGPRNSRCPDPHAAVDLINQLAVALSCCKHLTPSQSFHMVHWLYGYLRRHGGPVDPEFVRAMYHAGVVRYRRDGRRISATQYEYILWIVRKFESSEVVEELTALPQIGESRLDWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W6QDB6</accession>
    <name>W6QDB6_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acyl-CoA N-acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S02g002330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QDB6"/>
    <dbReference type="OMA" id="DEMPIAW"/>
    <dbReference type="OrthoDB" id="61870at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053225">
        <property type="entry name" value="Acyl-CoA_N-acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20958">
        <property type="entry name" value="GLYCINE N-ACYLTRANSFERASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20958:SF6">
        <property type="entry name" value="GLYCINE N-ACYLTRANSFERASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM32179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="431" mass="46641" checksum="DA6168E51CEE8AC8" modified="2014-04-16" version="1">MASTCIYEHDAATIIPALISELPYSTTLLRRIQHGIGYPHETAHILATFPPGLAPEPGQPWLAARVDLFAGRTTQMFIYSSLEAEHTSIPPIATVGDSIKATKPEILNVDSGSNNNRTKNGNDVGANPDTNTKSIVSTFSANPPVLALARAQLLDLLSYVKTKLLPSYLSYLQATSAEAESLPVSTSLVTPNTTPSTNSTSSVPLIAAPDPHAFLIGALHTGLFCLLQQSGSYTQSDPIPCIRVHRFDDPPYYKYFFRRSEFSPDADLPCADLSLPPGYRFHDRQGREGVLSKHLDLVQSRTHIPRPRSQLSTMPGMAVYFDGSSDDDEMPIAWGFLGVDGALATLHVEPEHRGRGLAAALSKAVMRHGMAVDGLFGAGSVNSEDSHTRECIGAWAHTDVAGYNHASRRVMEKIGGQVLTTVTWTVIELLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W6QDY2</accession>
    <name>W6QDY2_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">U3 small nucleolar RNA-associated protein 11</fullName>
            <shortName evidence="6">U3 snoRNA-associated protein 11</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PROQFM164_S03g001435</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">Involved in nucleolar processing of pre-18S ribosomal RNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the ribosomal small subunit (SSU) processome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 6">Nucleus</location>
            <location evidence="2 6">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the UTP11 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QDY2"/>
    <dbReference type="STRING" id="1365484.W6QDY2"/>
    <dbReference type="OMA" id="KWKVRER"/>
    <dbReference type="OrthoDB" id="29058at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007144">
        <property type="entry name" value="SSU_processome_Utp11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12838">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12838:SF0">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03998">
        <property type="entry name" value="Utp11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015952">
        <property type="entry name" value="U3snoRNP11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="62"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="121"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="74"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="121"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="148"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR015952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM34710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="288" mass="33508" checksum="FD42254EB8B57FF8" modified="2014-04-16" version="1">MSSMRNAVQRRNHKERGQLQGREKWGLLEKHKDYSLRAKDYNAKKAKLKRLEEKVRDRNPDEFAFGMMGEKNRTQGRHGRGKGTARDSAAAQGLSHEAIKLLKTQDKGYLRTVGERVRREIERLERDVKLQDGMNKVLGKKDGKKDESDDDGFDDDSDFDFGAPVQSKPTRVVFADDRQDQLAMKKQKIQKEEPALDSEEEEQTSSKTRKTPKQLEAERQALVDARRARKLRKRAIEARHNKLTALHKQYAEIRTAEQELDWQRAKMENSVGGTNRDGIKWKIRERKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W6QEA5</accession>
    <name>W6QEA5_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">N-acetylglucosamine-induced protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S03g001080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QEA5"/>
    <dbReference type="STRING" id="1365484.W6QEA5"/>
    <dbReference type="OMA" id="YHDWEDL"/>
    <dbReference type="OrthoDB" id="498286at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006044">
        <property type="term" value="P:N-acetylglucosamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022036">
        <property type="entry name" value="DUF3605"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35020">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-INDUCED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35020:SF2">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-INDUCED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12239">
        <property type="entry name" value="DUF3605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM34356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="222" mass="25718" checksum="FB8EEB9FF5DB9D4A" modified="2014-04-16" version="1">MPEVPEVPAFNLTELDHKLLAMTDEEYVYHDWEDLKSIIARNDLGALKRKPSDLRRYLAWTQETKVQYGTIMNYICQRRLKWDLPLNTASGTGSAVIQQSGTATFKNPRPFADPEDYKILRNDWPYGLTPGISHLVVWLRTPIPVQSDEGHLTDESRAIINGFVQKTFVHRLAKDPQNFSDPDSHVLWFKNWVGLQSVRALEHVHILVRDVPEDIIFEWVNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W6QEC6</accession>
    <name>W6QEC6_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Regulator of Vps4 activity in the MVB pathway</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S03g001542</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IST1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QEC6"/>
    <dbReference type="STRING" id="1365484.W6QEC6"/>
    <dbReference type="OMA" id="HEVREFT"/>
    <dbReference type="OrthoDB" id="29853at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.60">
        <property type="entry name" value="Vacuolar protein sorting-associated protein Ist1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005061">
        <property type="entry name" value="Ist1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042277">
        <property type="entry name" value="IST1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12161">
        <property type="entry name" value="IST1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12161:SF5">
        <property type="entry name" value="IST1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03398">
        <property type="entry name" value="Ist1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="147"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="268"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="277"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="294"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="388"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM34815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="400" mass="43519" checksum="4737389FCEA00422" modified="2014-04-16" version="1">MPPSAQTTRLVSTLRLLIPRLRLLQKKDTASSVVQRRELSQLLSEGRDASARIRVENVIATDIAVEVMEMVELYCELLLARANVLDQMAFSDQGTRARLRAKELLKKRTQEQAGATVSTTAGVKGAGESTGSIFGFSWLGGGAQKKEAERAAPITGSGSPADDSGDGLADDDNPYLDTALDEAATVVFYAWHRFPHEVREFTMLRTMLGERYGKEFMTLAQDNKIDTVKVPDRLLKGLRVRPPGRDLVESYLREIAKAYHVEWHGAEEELGSAPPEFVDDLGDGDDGDAEEPQLPQTPGKQQGDSALRPNLAEARRASETSELTKATPPRGLTAGRSPVSVAPPAPRTDNPNPRVKLPGTEGKAAAVSREDGASKSNSNNSGIPELDELTRRFADLKRRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W6QEH1</accession>
    <name>W6QEH1_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Peroxin-11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PROQFM164_S04g000014</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Peroxisome membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QEH1"/>
    <dbReference type="STRING" id="1365484.W6QEH1"/>
    <dbReference type="OMA" id="AYHPTVA"/>
    <dbReference type="OrthoDB" id="411017at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008733">
        <property type="entry name" value="PEX11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12652:SF50">
        <property type="entry name" value="PEROXIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12652">
        <property type="entry name" value="PEROXISOMAL BIOGENESIS FACTOR 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05648">
        <property type="entry name" value="PEX11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="1" id="KW-0962">Peroxisome biogenesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00046271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDM35133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="238" mass="26413" checksum="8F3EC942D9AD4E11" modified="2014-04-16" version="1">MVANTLIYHPALAHWLRFVATTAGRDKLLRTIQYFSRFYAWYLYRTNKPQSAIDPYNAVKKQFGTTRKIMRLGKFLEHLKAAAVAFDNKNPVDPVLRYLAIGRQLGYASYLTLDAITVIDVVGIRKLPSVKRVQQSAYRSWGTGLAFSVVAGVYTLIRLQAKEKTIDRKEGEGVVEAKKIEKERSAARIQLISDVCDLAAPLSAVGIVNLDDGIVGIAGTVSSLIGVWSQWRKTAGPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W6QFK5</accession>
    <name>W6QFK5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S02g003110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QFK5"/>
    <dbReference type="OrthoDB" id="4372765at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM32959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="172" mass="18720" checksum="18EBAF1F8B9242F8" modified="2014-04-16" version="1">MHAPEMGIFVIRAPIYKQYILPENRGSIYYPSTIANIFANRSMSRLNIFTLLMVYFGVSKANTKNYPTELPDSLPLGNIKTQPGKIYPPNIQGQPSSPPDIRLHHGGVSIQGEDPMRLSGGLSASPHRAASDPVPPKGNVTKVLSIKYPGALALSKAKLRIIIESQGKQTKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W6QFQ5</accession>
    <name>W6QFQ5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S04g000534</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ustYa family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QFQ5"/>
    <dbReference type="STRING" id="1365484.W6QFQ5"/>
    <dbReference type="OrthoDB" id="3687641at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021765">
        <property type="entry name" value="UstYa-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11807">
        <property type="entry name" value="UstYa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00035112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM35653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="135" mass="15744" checksum="7C8C25D3E9DECF94" modified="2014-04-16" version="1">MADRFKEKARTFENHQFAIKTSYFGFEATDQLEDIWNELLPEHPITIPSSRVESLGHGNSADDPDWIRDPHDTSNLLALPEYAVQLGCLNFLRQVGYRSDRDFTYLKSFQGDDSLVWARAYQCIERLRHAIMNFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W6QFV6</accession>
    <name>W6QFV6_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycoside hydrolase, family 71</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g002348</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QFV6"/>
    <dbReference type="STRING" id="1365484.W6QFV6"/>
    <dbReference type="OMA" id="DWEINIA"/>
    <dbReference type="OrthoDB" id="1046782at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051118">
        <property type="term" value="F:glucan endo-1,3-alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11577">
        <property type="entry name" value="GH71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005197">
        <property type="entry name" value="Glyco_hydro_71"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051130">
        <property type="entry name" value="Mito_struct-func_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43173">
        <property type="entry name" value="ABC1 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43173:SF33">
        <property type="entry name" value="ASCUS WALL ENDO-1,3-ALPHA-GLUCANASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03659">
        <property type="entry name" value="Glyco_hydro_71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004880181" evidence="1">
        <location>
            <begin position="21"/>
            <end position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM28537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="564" mass="62016" checksum="C8595670FE15314F" modified="2014-04-16" version="1">MKSAIFLILSLWRGVHHVQAAAVFAHFMLYNSENFTVSDWEINIAEAQKAHIDAFALNIAYNFPTNDRSLANAFKAAKTLSFQLLFSFDYVGNGAWPEGEVIGLLRKYGNNPAYYQHNGKPFVSTFEGSSNATDWTTIKKYTDCFFVPGWSALGAKEALAVAPGIPDGLFSWAAWPEGPDPINTYIDSTYMQWLKDTGHLPYMMPVSPWFYTNLPGYGKNWVWNGDNLWYDRWQQVLSLKPEFVEIISWNDYGESHYIGPLHEGSYATFEIGHASYNYATGHPHDGWRDFLPFIIDVYKGARPDVTTEGVTAWFRLAPGKACANGDTTGNTKTHGQKEFPPTDVLQDEVFYSALLRNAMDVDVSVGIGGVVQDGKWKNRPHGPIGIYHGSVPFDGNTGQVIVTVSRQGKTVAEMRGASISESCPDDIQNWNAWVGTKFANNTISRPPPSPAPTEVSAASALLALWRIPFAIVFVALVATMVAATATPVQHEKLALTIPISEGSPSVYSAGAGDDDPRSLYSHGTSYGLYPINGYTRTTTTGALITPFTPTGATAFTYSTSWNLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2024-10-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>W6QFW8</accession>
    <name>W6QFW8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S04</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S04g000166</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QFW8"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM35285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="55" mass="6359" checksum="56E3B1E85BD8268E" modified="2014-04-16" version="1">MNTRDNLFWNTAAVGNRRVEIVDILLRNQGRRISGRSIPSTHEPIVQLLLWNSET</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W6QG19</accession>
    <name>W6QG19_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Succinyl-CoA:3-ketoacid-coenzyme A transferase</fullName>
            <ecNumber evidence="3">2.8.3.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PROQFM164_S03g001643</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a 3-oxo acid + succinyl-CoA = a 3-oxoacyl-CoA + succinate</text>
            <dbReference type="Rhea" id="RHEA:24564"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:35973"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
            <dbReference type="EC" id="2.8.3.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Ketone metabolism; succinyl-CoA degradation; acetoacetyl-CoA from succinyl-CoA: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the 3-oxoacid CoA-transferase family.</text>
    </comment>
    <dbReference type="EC" id="2.8.3.5" evidence="3"/>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QG19"/>
    <dbReference type="STRING" id="1365484.W6QG19"/>
    <dbReference type="OMA" id="GMGPHPT"/>
    <dbReference type="OrthoDB" id="1933379at2759"/>
    <dbReference type="UniPathway" id="UPA00929">
        <property type="reaction ID" value="UER00894"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008260">
        <property type="term" value="F:succinyl-CoA:3-oxo-acid CoA-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046952">
        <property type="term" value="P:ketone body catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1080.10">
        <property type="entry name" value="Glutaconate Coenzyme A-transferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012791">
        <property type="entry name" value="3-oxoacid_CoA-transf_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014388">
        <property type="entry name" value="3-oxoacid_CoA-transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004165">
        <property type="entry name" value="CoA_trans_fam_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02428">
        <property type="entry name" value="pcaJ_scoB_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13707:SF60">
        <property type="entry name" value="ACETATE COA-TRANSFERASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13707">
        <property type="entry name" value="KETOACID-COENZYME A TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01144">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000858">
        <property type="entry name" value="SCOT-t"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00882">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 5" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="5-glutamyl coenzyme A thioester intermediate" evidence="4">
        <location>
            <position position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR000858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000858-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDM34916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="541" mass="57557" checksum="64EEEA6B08C6C12E" modified="2014-04-16" version="1">MSALRISTTLSRKALTACRPRLFIGVRASVRPLQPFSTSTTRYSLTTPSATLAPKIDRSRSKLYKDADAAVADIKSGSTILSSGFGLCGVAETIINAMHRRGADQLHSLTAISNNAGSAAGGLSILSKNGQINRLILSYLGNNKALEKKYLTGHTAIELCPQGTLAERLRAGGAGIPAFYTPTGAHTFIQEGKIPVRMDESGKVLESGKARETREFNGKTYLMEEALTGDVAILRAWKVDEAGNCVFRYTTKAFGPIMAKAATLTIVEAENIVPVGAIDANDVDLPGIYVDRIVPATDDKHIENKKLRQEPSVAGPTKSAAQLQRELIARRAAKELKPGFYVNLGVGIPTLAPSFLPKDVKVWIQSENGILGMGDYPTEETLDPDIINAGKETVTLVPGAATFDSAESFGMIRGGHVDVSILGALQVSANGDLANYMIPGKIFKGMGGAMDLISNPDKTKIVVATSHVAKDGTSKIVQKCTLPLTGAKVVSTIITNLCVFQVNRATGELTLTELAPGVEVEEVQSKTDAKFTVADTLEIME</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W6QGB0</accession>
    <name>W6QGB0_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD-superfamily hydrolase, subfamily IA, variant 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S01g002488</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="1365484.W6QGB0"/>
    <dbReference type="OMA" id="TAPNGFW"/>
    <dbReference type="OrthoDB" id="1694274at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052898">
        <property type="entry name" value="ACAD10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47829:SF1">
        <property type="entry name" value="HAD FAMILY PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47829">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12880)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM28677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="259" mass="28921" checksum="D97526B5CFFC006B" modified="2014-04-16" version="1">MAEIKRPVGLLFDVGGVCVASPLQAILDYEIIRNIPSGWINFSISRTAPNGSWHKLERGDIGVDTDFFAGFNADLASPELWAQFQQQLQKKQGTNGSTIPPMPTVDAEWLFWEMMRVSRTTDPYIYPALKKLRESGQFLMGALSNTIIFPDGHEYNEASEVKKQFDFFISSAHTGLRKPDPKIYQVALQEMDNLAKRRGLAGANPDDVVFFDDIGENLKGAKNAGMRTVKVILGKTQDAVKELEKLTGLQLLEEDKARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W6QGC5</accession>
    <name>W6QGC5_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Long chronological lifespan protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">lcl2</name>
        <name evidence="6" type="ORF">PROQFM164_S04g000739</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
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                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Probable component of the endoplasmic reticulum-associated degradation (ERAD) pathway.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LCL2 family.</text>
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        <property type="protein sequence ID" value="CDM35858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="LCL2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38425">
        <property type="entry name" value="LONG CHRONOLOGICAL LIFESPAN PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38425:SF1">
        <property type="entry name" value="LONG CHRONOLOGICAL LIFESPAN PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004880206" description="Long chronological lifespan protein 2" evidence="5">
        <location>
            <begin position="22"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDM35858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="123" mass="13701" checksum="EFE6EE212245B8A6" modified="2014-04-16" version="1">MLQSWRQAIWALLLLVSVAQAQFNFFDQMFGGGEQQQRQQQRSQNAPSDSDRYQQMWNGAQCDHYLCPGTLACVHFPHHCPCPHPGVEEKVELGEGSAICVSKGGFKAGEAARKIELARKGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2024-10-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>W6QGF2</accession>
    <name>W6QGF2_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S03</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S03g001783</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM35056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QGF2"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM35056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="78" mass="8756" checksum="6ED74EF9E53DA429" modified="2014-04-16" version="1">MYRPDRRRLAALFRALRADIHPPKYPSPPASVQQSGQCFHAWNLVTVTSWSVRISAHARPPAAGCQFNRAGGPHFEVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W6QGS7</accession>
    <name>W6QGS7_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SWAP/Surp</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S01g002613</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QGS7"/>
    <dbReference type="STRING" id="1365484.W6QGS7"/>
    <dbReference type="OMA" id="VWYRWKL"/>
    <dbReference type="OrthoDB" id="377209at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.790">
        <property type="entry name" value="Surp module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006569">
        <property type="entry name" value="CID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051485">
        <property type="entry name" value="SR-CTD_assoc_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000061">
        <property type="entry name" value="Surp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035967">
        <property type="entry name" value="SWAP/Surp_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23140">
        <property type="entry name" value="RNA PROCESSING PROTEIN LD23810P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23140:SF0">
        <property type="entry name" value="U2 SNRNP-ASSOCIATED SURP MOTIF-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01805">
        <property type="entry name" value="Surp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109905">
        <property type="entry name" value="Surp module (SWAP domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51391">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="CID" evidence="3">
        <location>
            <begin position="446"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="253"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="407"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="662"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="725"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="666"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="727"/>
            <end position="742"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM28802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="781" mass="86388" checksum="C60696E0B34F19D3" modified="2014-04-16" version="1">MPDESKGKSFPDVSAKLSALPKKSLFERQKAEAEAKRAREKAETAAVYEEFVKSFEDEDSVAPQSWDGGSNTFRGRGGGPPRRHFATSSSRGSGHGSLGPPPPSLSHKRSHETFPPSRRDHLKFENVLTPSETDRALDEEERAAPKPTLYLASLPPGTSLSVIKALIPSTLTVDNVKIITPPGQLPTHRESSSALVTLSSDSAASTIDAAVSTLQNKYLGWGYYLTLCRHLSSIAINSNMPLPSGLSSTTTSLPFGAKPIPPSLGTSLSRAPPPGPHRGGFAPPSSYGPSVGRNGPTTQVQVELPTDIRQLRQIHMTIEKLVKQGPGFEALLMSRPEVQMDEKWAWLFDPRSPGGVYYRWKLWQIITDPKKKNIDKPAMIFEGGPLWLPPKQHLKFENVTRLDQFVSHPDYDSSDEEHSDGENERRNLGGAPQDGSNTRSDEPNFLNPLKMAKLTHLLARLPTTHSKLRRGDVARVTAFAIDHAAVGAPEVVDMAIRNVFRPLAYTGANPNREMEKSAARLATTDKDNATPSDEQLDMSSAKLVGLYIISDILSSSATSGVRHAWRYRQLFENALRSRKVFEHLGRLDKDLKWGRLKAEKWKRSVGALLHLWEGWCCFTQLNQEHFTQVFEKPPLTEAELQKQKETEKTNADQAAVAFAKSKSRWKTVDDERGGKFDPTRPANENKLSLSAHAVDESVHGKDGTAMEICELKNVDGEFMLKAPLSGDQDTQTEIPQTLSQNPPQHPTQPDKSEQSAGQQEPETRRRKPRPKAEDMFASDSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W6QHB4</accession>
    <name>W6QHB4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="12">F-box domain, cyclin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PROQFM164_S03g000313</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QHB4"/>
    <dbReference type="STRING" id="1365484.W6QHB4"/>
    <dbReference type="OMA" id="RMKSVWD"/>
    <dbReference type="OrthoDB" id="421226at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005221">
        <property type="term" value="F:intracellularly cyclic nucleotide-activated monoatomic cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000057">
        <property type="entry name" value="Cyclic nucleotide-binding domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000174">
        <property type="entry name" value="Cyclic nucleotide-binding domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050866">
        <property type="entry name" value="CNG_cation_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018488">
        <property type="entry name" value="cNMP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057207">
        <property type="entry name" value="FBXL15_LRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45638:SF24">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-BINDING DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_2G03170)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45638">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-GATED CATION CHANNEL SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16643">
        <property type="entry name" value="cNMPbd_u2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25372">
        <property type="entry name" value="DUF7885"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00889">
        <property type="entry name" value="CNMP_BINDING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="10">
        <location>
            <begin position="64"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="10">
        <location>
            <begin position="266"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="F-box" evidence="11">
        <location>
            <begin position="551"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="229"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="447"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDM33589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="932" mass="103062" checksum="D3D69BA73AAE4C81" modified="2014-04-16" version="1">MRRHGRSSGGPTKAVSPLSDTVSLIRSFDSVMNPNRPARPSPLASSHIQALPLELVDRLRSFPLFQATPESFLIEVGQHLRPQLHAPNDYILTEGDESKAIYWLVRGAVSVTSRDGESIYAELKPGAFFGEIGLLMDRPRTATIIARTRCMLVVLTKDDFRNILPRYPEVEQAIREEAEERLMILEKKKKETSAPALDMPSPARRGSKRLRESISKGLAVAEDDGDVSAKSVYKKRKSPSPGRRDGSSALANGLVNVRLLLKELPLFSGLPADILHYLGLNAQPRSFPPFTDIIQQNSQGRELYFIVRGEVEVLTEKAEMDHSSANKTSPNGHIEQPGIEVKARLKQGQYFGEVVSLDLAPRRTATVRSVTSVECLMLGGDVLAKFWEKCPSDVREQVQRTAQARLQAAADGDVIMSDEADSQPSLGDLALDDRVKITSSRRRSMPLLTLTETELDGPHQSSNAEDQDQDVLRPSDPDPYFSMGLDKVRMRSRRGSLAPLAPEEVSREQQRSSPTELCSASSSTLALSETASLSKSYHTERPRVDGTNGLLPDSVLLNIFQFLELHQLLRIRAVSSHWSDLLTRSADVIHDLDLSVYNRRITDDVLVKIICPFIGNRARSVNINNCFHITDEGFTVLAATCAPNITAWKMKSVWDVTASAILDMSSKATNIQEIDLSNCRKVGDTLLARIIGWVVPADQTMGEKQSSIKPTIQTAEFTVYGCPKLKKLTLSYCKHVTDRSMHHIASHAAGRIEEMDLTRCTTITDQGFKYWGNAQFTNLRKLCLADCTYLTDNAIVHLTNAAKNLEELDLTFCCALSDTATEVLALQCSHLKYLNMAFCGSAISDPSLRSIGLHLLSLQHLSVRGCVRVTGVGVEAVAEGCHQLRVFDVSQCKNLAPWLEDGGAVHYQPRVEFKTVAPNKKLPRLGSNTYKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W6QHJ9</accession>
    <name>W6QHJ9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S05g000091</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QHJ9"/>
    <dbReference type="OMA" id="NIMPVAW"/>
    <dbReference type="OrthoDB" id="4288742at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM36258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="246" mass="26262" checksum="C064F352BC62CCBA" modified="2014-04-16" version="1">MPPQTVGPRFKKCVAKHVAKRVVKRVVKRVAKRVAKRVAKRVAKRVAKRVAKYQSVYHPSILINIRNMTFSIFLLLASVYIRAALGGSLTVIDYDRQCVIWSDDNYGCTGHSSSFGLLDGDDCSDLSMITHGIRKDYSKLDVGVCGSTKDNIMPVAWIDINENGMVKFYNQNGDETGCTLDNGFKVGSSCIASDLSSPSSSASSSESSLSASESSSSSESTPSISASSPSSTSASSSEISSCTNSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W6QHV4</accession>
    <name>W6QHV4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ATP12, ATPase F1F0-assembly protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PROQFM164_S01g002999</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATP12 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QHV4"/>
    <dbReference type="STRING" id="1365484.W6QHV4"/>
    <dbReference type="OMA" id="WQTNQWG"/>
    <dbReference type="OrthoDB" id="5322896at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033615">
        <property type="term" value="P:mitochondrial proton-transporting ATP synthase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3580.10">
        <property type="entry name" value="ATP12 ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2180.10">
        <property type="entry name" value="ATP12-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011419">
        <property type="entry name" value="ATP12_ATP_synth-F1-assembly"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042272">
        <property type="entry name" value="ATP12_ATP_synth-F1-assembly_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023335">
        <property type="entry name" value="ATP12_ortho_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21013:SF10">
        <property type="entry name" value="ATP SYNTHASE MITOCHONDRIAL F1 COMPLEX ASSEMBLY FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21013">
        <property type="entry name" value="ATP SYNTHASE MITOCHONDRIAL F1 COMPLEX ASSEMBLY FACTOR 2/ATP12 PROTEIN, MITOCHONDRIAL PRECURSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07542">
        <property type="entry name" value="ATP12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160909">
        <property type="entry name" value="ATP12-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="34"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="49"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM29187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="436" mass="48709" checksum="AFD95530BF77028F" modified="2014-04-16" version="1">MVAFARAALSSQLSAVARPVSLCRRIHSSHFRSAVAHPITAHGPPPKAPELKEKSKPKEAELPAPEGEGSRYNLTAALRKRFWKDVHVHGKSDEYQVLLDKRPVRTPTKEVLTIPSTKPHLAHAIALEWDVMASAQEALKSHLIPMTSLAARATDIAREDAEGKNTTRKQILTTAMRYLDTDTLLCWEPEREMHVLERTAADGTPIESLRQIQTRIAGNVMSFLSTKVWPGLEIIPILDANSILPLAQPKGTKDSIGTWVSGLSAYDLAGLERAIIASKSLLIAVRLVVEWSENFRHLQRPETKRFGIEEAAEASSLEVTWQTNQWGEVEDTHDVGKEDLKRQLGSVVILVSGETRSILRHGEETKERTTKKGQVVDQKVIFPHDHTKTSQRLFIKRGDLLESRVDHPNGLLEFDIDRLREYATCALCRMDLTPAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W6QIR0</accession>
    <name>W6QIR0_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Vacuolar protein sorting-associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PROQFM164_S05g000536</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Mediates the transfer of lipids between membranes at organelle contact sites. May play a role in mitochondrial lipid homeostasis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the VPS13 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1365484.W6QIR0"/>
    <dbReference type="OMA" id="SGWRPIR"/>
    <dbReference type="OrthoDB" id="428159at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045324">
        <property type="term" value="P:late endosome to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045053">
        <property type="term" value="P:protein retention in Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026847">
        <property type="entry name" value="VPS13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056748">
        <property type="entry name" value="VPS13-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056747">
        <property type="entry name" value="VPS13-like_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017148">
        <property type="entry name" value="VPS13_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026854">
        <property type="entry name" value="VPS13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009543">
        <property type="entry name" value="VPS13_VAB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16166:SF93">
        <property type="entry name" value="INTERMEMBRANE LIPID TRANSFER PROTEIN VPS13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16166">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VPS13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25037">
        <property type="entry name" value="VPS13_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25033">
        <property type="entry name" value="VPS13_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12624">
        <property type="entry name" value="VPS13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25036">
        <property type="entry name" value="VPS13_VAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037235">
        <property type="entry name" value="VPS13_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="3 4" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Chorein N-terminal" evidence="6">
        <location>
            <begin position="1"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="domain" description="VPS13-like middle region" evidence="7">
        <location>
            <begin position="1082"/>
            <end position="1863"/>
        </location>
    </feature>
    <feature type="domain" description="Vacuolar protein sorting-associated protein 13 VPS13 adaptor binding" evidence="8">
        <location>
            <begin position="1930"/>
            <end position="2506"/>
        </location>
    </feature>
    <feature type="domain" description="Intermembrane lipid transfer protein VPS13-like C-terminal" evidence="9">
        <location>
            <begin position="3028"/>
            <end position="3134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="553"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="849"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1036"/>
            <end position="1057"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1358"/>
            <end position="1400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1539"/>
            <end position="1562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1700"/>
            <end position="1758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="553"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="867"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1036"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1046"/>
            <end position="1057"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1544"/>
            <end position="1556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1700"/>
            <end position="1709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1710"/>
            <end position="1720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1723"/>
            <end position="1735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1739"/>
            <end position="1757"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR037235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF25033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF25036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF25037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDM36703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="3159" mass="354827" checksum="A0A9F77C8040C536" modified="2014-04-16" version="1">MLEGVVANLLNRFLGIYVKNFDATQLNIGIWSGDVKLRNLELRREALDQLRLPLNVVEGHLGELTLSIPWSNLRGKPVKVDIQDVFLLAAPREDADFDPEEEAKRENALKMERVESAEILRERNAEGMSQEEQRRNQSFTQSMITAVVDNLQISIKNVHFRYEDSIASPGHPFAVGVTLKELSAVSTDGEWNPTFIQSDSSVTHKLAVLGALSAYWNTDAKLLGTGRGSDIGAEAQGISRADLIEKLRTAIDADEGNQFMLRPVSGRAGLEMDKSGTYERPAIKARLLFDELGFVLDEKQYRDALMLVDLFHYFIRHQEHKKIQPKASPKEDPRAWMRFAGEAVLSKIHERNRRWTWDYIKERRDDRIAYIALFKKSKKEEAFTPEETKELQRLEAKLSYEDIRFWRSLARNQLRKENVGVKKPAEQQSWSAWLWGAKKEESEETAMTEEQRQELYNAIDWDEKKAITESVDVPREWVKLQVNWSLRAGSFTLIQDPHGSANEVMKLVFDNFRAKALQRHDSYLLDLDLGGLKMYDGTTAGTLYPQIVKVKDSPPESTKVEELSEDDDELASQTSADDLQDEDSLFHLQLEKNPLDSDADTAVKVKLKSIEVIYNPRFLVGIVKFFEPPERHMESIGALLDTAGATVEGLRQQTRAGLEFALQEHKKVDAQFDIHAPLIIVPESITQPSSLCLIIDAGHASVNSELVDRKAMREIQSKQKKQYAEDDYKQLEHLMYDRFLIKLDSTQVLIGPGVDATKAQLNTNVESRNFHIIDRINVDFALEMCIVPSVTQLTRTRISGHLPELHASISDTKYKGLMKLIDIAIPEFDTEKSASDSVTAAAKEEAALATRDRSSSFQPAVQRDLPVVDDDEDEVDSEHAKKRVDTPANIHRRDFEFKFTVGRLRGSLSRSDPHDPQRDQLLVELVAEGFELDFYMRPYDMVAEVILKSLSVDDHIEENPVPEFKRIISSKGFDADEDKDLFQLKMVRVKPESPEFDSTYEGVAMNLDISVSTINLVVTRKTLLTLLDFTLLTFTNPQQPTQPNPETDKAIEGTASVEEKPEQAGKIRIKANLKSIALILNNDGVRLATLSLNTADVGVFLVGSSMLIQSRIGSLTLVDDVNLGAAEDSDIRRLLTIEGDDFADFKYETFDPDSETHPGYDSEVYLRSGSIKINFLEEPYRKIIHFLVKFGKMQAIFNAARQAAASQANQLQENASRVRLDIIVKTPIVVFPRVMTDGRPRDTITAHLGEIYAKNEFVPMDDGKDSPAVNVISTGVRNIRLTSNFHFEDGTSEELEMIQKVNLEFSICYLEHQANNPRPDMEIEGSLSPINLRISQSQLKFLLELSKSIPNAFATDTEQQELEAMESLPSSVTEPTREASSKAVQAQNGSGGAPPDDENRETWVRLDMIFKVDSVGLELILANDDQPVGRLEDSSLSKFSLNDTRVKLRMLTDGSLESELLIHSFSIRDSRKQDSNKFRNIMSLINNDVQQQFMASVSMSGGPEKHLIAMLTIDSPRIMFALDYLSALQSFSQSAFASEGPIEVQDESESPEESESGSDTIVSSNKAITEASSGDATAAAMTVSFRVNLVDAQVIMVANPAIPHSEAIVLGTKEVLISHQNVSTLQIQKVGMFLCRMDKFETSRLRILDDFTLEMSIDSRSQDKGSALTSIEVHLEPLVLRLSLRDILMAIQIVNKASEMTQNAQQTESGEAKKITDTKTTRGRSSSKTSSAVVKRSNRPSQGAGNLDRTTAPQSSVVLKREEMSAKIDGVRVILIGDLHDLPLVDWSVKKFNIDVRDWSSTLNADTNFETFMNVYNFSKSAWEPLIEPWQLGFHMAKETNPDVFSFDVYSHKTMELTITSATIALASKSFQFLSTDQDVLAKPRGADAPYRIRNYTGFDLSVWADVSEGVEGPAAKLTDGEEAPWRFEDSTAIRESLTPEGHGGVVGVKLEGSGFDSISRIPVVREGEVIYALKPKQQSVLHRLLVEVKLGPDNVKYITFRSPLLIENNTQIPVEMGIFSPGEGHLLKIEKILPGDARPAPVGSAYLHSIVVRPDQGFGYDWSDERLFWKDLIKRPTRTVKCISENGQQAPPFYFQVNATFDSKDSLTSVYPYMRIRIFAPVEIQNLLPYDFKYRIYDKNTKKDWTNFLRKGGVSPVHVVELSHLLLLSIDLQDSVFRQSEFAIVNGNAQDYRREHTLTLKDERGLQLRLQLHYFNIPNSGGAFKVSVYSPYLVLNKTGLPMDIQSKAFLQSARNAAGQGLRADPRDEGRALPYMYSYANEDQSNRSILKVSDSAWSKPQSFEAIGSTFEVIFPDRQGRSEFHSGVSVAEGEGKYKMTKVVTLAPRFILKSKLNEDLLAREPGSSNVLQVKNGQLVPLHFLRQVQEKQLCLCFPGVNNQWSSPFNIADVGTVHVKLAKANQRQKLIKIDIIMEGATLFLHFSLEQRNWPFSMRNESDMEFIFYQANPNVEDDDEEDQTSGWRPIRYRIPARSIMPYAWDYPATKNKSLVLTCQGKERHIKLAEIGNLIPMRIPASQPGEHQKIIDINIAADGPTQTLVLSNFKPSKSMYKQQSRQSSQVGSTAGFEIKEMNSDVNFKAQLRLGGIGISLINQNLKELLYLTFREIEFKFRESRLYQTLNATIKWIQIDNQLYGGIFPILLYPSVVPKTGKEMEAHPIFHAMVTRVKDDSYGVLYIKYATLLLQQMTLELDEDFVLAMLDFVKIPGASWAEEQEGKLCDEDLNIPEPRQEDNGQDVYFELLHLQPMQMDISFMRTERVNVEDTMQPSNPLMFFVNVMTMSMGNVNDAPVRLNALMLENARVSFPSLVANIRAHYTQEFLGQIHIILGSADFLGNPVGLFNNVSSGVAAIFYEPYQGLVMTDRPQELGLGIAKGATSFMKKSIFGFSDSMAKLTGSMSKGLAAATLDKEFQNQRRMSKVRNRPKHALYGITAGGSAFATSLASGIGGLARHPLQGAEKEGIQGFFKGVGKGVLGLATKPAIGAFDLASNLAEGVRNTTTVFDAEGLDRVRLTRFIGTDGIVRPYSQREALGQFWLKTTDDGKYFDEDYIAHLELPGRDMLVLLTYARIMLVRTKKLYTEWDIRLTDIQTISKERTGMSITLKGGANGPFIPVQDESSRNWLYRQIAVAVNAFNEKYNSRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W6QJ13</accession>
    <name>W6QJ13_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S05g000606</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QJ13"/>
    <dbReference type="STRING" id="1365484.W6QJ13"/>
    <dbReference type="OMA" id="FYRSQMQ"/>
    <dbReference type="OrthoDB" id="9978720at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12809">
        <property type="entry name" value="Esterase_713_like-2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050228">
        <property type="entry name" value="Carboxylesterase_BioH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43194:SF4">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43194">
        <property type="entry name" value="HYDROLASE ALPHA/BETA FOLD FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004882082" evidence="1">
        <location>
            <begin position="23"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM36773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="363" mass="39824" checksum="44604FF58EF4723B" modified="2014-04-16" version="1">MCKLMAPSLGTLFLGARFSTLADDTRTSQQENATNSTSMVMIGQIYVEKLSPQSAPVNPPLPIIFIAGAAQTGTNFLDTPDGRPGWASYFISKGHTVYLSDQPARGRSFWSPGQGSIGYIGSPDSVSDIFTDVANNDNQWPQAKLHTQWPGTGRIGDSTFDAFYRSQMQFQTDRFISEEQNAQAYSALVDLVGDCYIISHSQAGAYGWRVGDMRPDLVKGIVQLEPSGPPFTLRPPFGNDPAFAFGLTDLAIGYEPSAGENAENIETTIEPAIDADHDQCIMQKSPARQLTNLGKIPELVVTGEASFHAPYDYCTVKYLEQAGVDVEYADLGKEGIHGNGHMFFMEKNNLEIADRVYKWLEKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>W6QJB5</accession>
    <name>W6QJB5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">PROQFM164_S01g003489</name>
    </gene>
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        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QJB5"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM29677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="57" mass="6313" checksum="BAEEACBBF7DBC021" modified="2014-04-16" version="1">MTPVTVSLPCDTLKGVIDGALCGVKGELNKKITAFLTDKGQLYTKDEWLQRYPEPTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W6QJT0</accession>
    <name>W6QJT0_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Biogenesis of lysosome-related organelles complex 1 subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PROQFM164_S03g001203</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BLOC1S1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OMA" id="DNEMRTR"/>
    <dbReference type="OrthoDB" id="20018at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031083">
        <property type="term" value="C:BLOC-1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009395">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR13073:SF0">
        <property type="entry name" value="BIOGENESIS OF LYSOSOME-RELATED ORGANELLES COMPLEX 1 SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13073">
        <property type="entry name" value="BLOC-1 COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06320">
        <property type="entry name" value="GCN5L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="124"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="53"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="124"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDM34479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="175" mass="19468" checksum="BC0734930A9B4C8F" modified="2014-04-16" version="1">MDNPTPQPNPNPNPTADPENPTADQQQKEALAAFTATLHSVGTNLEAPLRDRAANIQSNAVVLERQEAELAENTQRLARQNQQWIGFADETRDGLKEIGDVQNWAEMIERDLLALEDMMDVVESGHGEHGSEDGDDRGDSDTELDDNASEQNGNVDIDANGKNVDRRPKGWLRWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W6QL19</accession>
    <name>W6QL19_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cupin, RmlC-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S03g001606</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QL19"/>
    <dbReference type="STRING" id="1365484.W6QL19"/>
    <dbReference type="OMA" id="HSFRNRS"/>
    <dbReference type="OrthoDB" id="5840532at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02231">
        <property type="entry name" value="cupin_BLL6423-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047142">
        <property type="entry name" value="OryJ/VirC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36156:SF3">
        <property type="entry name" value="CUPIN 2 CONSERVED BARREL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36156">
        <property type="entry name" value="SLR2101 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin type-2" evidence="2">
        <location>
            <begin position="90"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM34879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="195" mass="21784" checksum="C4166525BCB1E7E2" modified="2014-04-16" version="1">MSPYEKNPLPYIRRYITTHSNDGESIFLSHAQVPDYLPSTPTGEDGEIALLYATTSMPASVDAEADIAMYDEFLHQPPGVTVDNGTVFRLIDLRPGKATPMHRTVSVDYGVIIEGDVDLILDSGSSRHLHRGDVSIQRGTAHSFRNRSDTKWCRMLFVYLPMEKSSVQGKELKEEVYDEGFDKPDDEEGDQGNST</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W6QL39</accession>
    <name>W6QL39_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S03</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S03g001631</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QL39"/>
    <dbReference type="STRING" id="1365484.W6QL39"/>
    <dbReference type="OMA" id="ARFFSMN"/>
    <dbReference type="OrthoDB" id="5440at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030638">
        <property type="term" value="P:polyketide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009959">
        <property type="entry name" value="Cyclase_SnoaL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38436:SF3">
        <property type="entry name" value="CARBOXYMETHYLENEBUTENOLIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38436">
        <property type="entry name" value="POLYKETIDE CYCLASE SNOAL-LIKE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="406"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="412"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="428"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM34904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="509" mass="56600" checksum="AD8ED3105E5D0933" modified="2014-04-16" version="1">MANISISAPGLSSGGFLYNNGNNNARLCITAETEDFDIEIIKNWQEEGFDVLYLPYNGGGKDYARRLQSVKDGLGVGENYAVVAYGDAADYCLGYYINSINASRLCALVAYYPSLIPDTRSRFPLSLQVLVHLAGKTVDVLVQPVALGLQGKKRRQTRPINAGIGTGERLDLGYPAFTYDNAVPGFAETDLEEYDRLSAELAWSRTLKVLRKGYSRDPDYEQRYEQHVEAKFFSSNVKKTMDGYVQHKTPSVTYTPTISGGIGKKSLRHFYEHYFIGKLPPSMRLRLLSRTTGSDRIVDELYVSYEHTQEVPWMLPGVPATNKRVEIILVSIVSLRGGRLYSEHVYWDQASVLVQVGLLDPKLLPNGVQGVDRLPVVGREAARRILHEDTELEQEDYHNKMIRRARARARRSLNQSSRLSQAGDESAADLKSEAEQSLPDRSRDKGKSVQKTKPASLQRAAMEAAEHGGDDDANTETETSVKARSEADNQAAYVEDGENDSAENGSKQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W6QL62</accession>
    <name>W6QL62_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">non-reducing end alpha-L-arabinofuranosidase</fullName>
            <ecNumber evidence="4">3.2.1.55</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">abfC</name>
        <name evidence="10" type="ORF">PROQFM164_S02g000411</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Alpha-L-arabinofuranosidase involved in the degradation of arabinoxylan, a major component of plant hemicellulose. Acts only on small linear 1,5-alpha-linked L-arabinofuranosyl oligosaccharides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing alpha-L-arabinofuranoside residues in alpha-L-arabinosides.</text>
            <dbReference type="EC" id="3.2.1.55"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycan metabolism; L-arabinan degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 51 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.55" evidence="4"/>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QL62"/>
    <dbReference type="STRING" id="1365484.W6QL62"/>
    <dbReference type="OMA" id="GETSPKW"/>
    <dbReference type="OrthoDB" id="3032304at2759"/>
    <dbReference type="UniPathway" id="UPA00667"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046556">
        <property type="term" value="F:alpha-L-arabinofuranosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031222">
        <property type="term" value="P:arabinan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046373">
        <property type="term" value="P:L-arabinose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010720">
        <property type="entry name" value="Alpha-L-AF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055235">
        <property type="entry name" value="ASD1_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43576:SF3">
        <property type="entry name" value="ALPHA-L-ARABINOFURANOSIDASE C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43576">
        <property type="entry name" value="ALPHA-L-ARABINOFURANOSIDASE C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06964">
        <property type="entry name" value="Alpha-L-AF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22848">
        <property type="entry name" value="ASD1_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00813">
        <property type="entry name" value="Alpha-L-AF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-L-arabinofuranosidase C-terminal" evidence="9">
        <location>
            <begin position="308"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDM30262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="505" mass="56367" checksum="F7ECEFB75CFA8152" modified="2014-04-16" version="1">MTTFTKLDDHETPLISVHPSRRISKINPNIYAGFTEHMGRCIYGGIYDPGNPLSDEKGFRKDVLEALKGLNIPVVRYPGGNFCATYHWLDGIGPKNQRPARPELAWLGTETNQFGTDEFMQWCEALGTEPYLCFNFGTGTLDEALGWVEYCNGTGNTYYANLRRKNGREEPYNVKYWALGNECWGPWQVEQMTKEAYAHKAIQWAKALKLLDPTLILILCGQDGTASWDYYTLNQCLVPAHSALSTSSVPLIDMHSIHLYTSSSSHLLNVTAPLAAERAIEITSALIDLARVVNKVPPEQLRPTICFDEWNVWDPIRAEGSLGAEENYTLSDALAVAVWLNVFVRKSKDVSMACIAQTVNVISPLMTTPEGITKQTTWWPLWLFSRYMRGWTVASHVSCGTYEGETSPKWIRSAKDTPWLDVSATVGDDGFVNVAVVNIHDSRDLESHVEGAQGEVAVFTVTAGDLSVTNLNGKEEVAIQESTWTGSGQYVFPRHSLTLLRWKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>W6QLP3</accession>
    <name>W6QLP3_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">glucan 1,3-beta-glucosidase</fullName>
            <ecNumber evidence="10">3.2.1.58</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Exo-1,3-beta-glucanase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">BGL2</name>
        <name evidence="14" type="ORF">PROQFM164_S02g000636</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>Successive hydrolysis of beta-D-glucose units from the non-reducing ends of (1-&gt;3)-beta-D-glucans, releasing alpha-glucose.</text>
            <dbReference type="EC" id="3.2.1.58"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the glycosyl hydrolase 17 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.58" evidence="10"/>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QLP3"/>
    <dbReference type="STRING" id="1365484.W6QLP3"/>
    <dbReference type="OMA" id="EGICAMR"/>
    <dbReference type="OrthoDB" id="1293114at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042973">
        <property type="term" value="F:glucan endo-1,3-beta-D-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004338">
        <property type="term" value="F:glucan exo-1,3-beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050732">
        <property type="entry name" value="Beta-glucan_modifiers"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000490">
        <property type="entry name" value="Glyco_hydro_17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631:SF26">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00332">
        <property type="entry name" value="Glyco_hydro_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0134">Cell wall</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004882156" description="glucan 1,3-beta-glucosidase" evidence="13">
        <location>
            <begin position="21"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00036824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00041761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDM30487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="316" mass="34149" checksum="CF5CA71339F2FF75" modified="2014-04-16" version="1">MRASGVVSLLLAAAPALVSAKGTLGFSLGDKNADGTCKSTSDYEADFDALKSLSTLVRTYSGTECNTPQNILPAAKNKGFKVVLGMWVGKPTDTNNLLEEPSFKGDWAAIQKAIPGYEDVIHAITVGSETLYRGDLTGPQLHTYISHVMDNVPKGVLVGTAESWNKLADGTGDALFTQEPVVTYVLANAFAYWQGTAADKAYQTYFDDMAGAMEHIQKIAGDNADKINIVTGETGWPTDGGSDYEAAKAGTKNAQTFWKTGICGMLDWGVDLFYFEAFDESWKPDTKGDNGEMKDEKHWGLFTADRKVKFDTSCPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W6QMT7</accession>
    <name>W6QMT7_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S10g000017</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792024">
        <property type="protein sequence ID" value="CDM38203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QMT7"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM38203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="55" mass="6166" checksum="733F7CB66100CC6E" modified="2014-04-16" version="1">MGRRIFLGQDPLKNSTSAFFVPISESILLGIRSIRTISDGQLDLFSPEERNHPHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2024-10-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W6QMV5</accession>
    <name>W6QMV5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S10g000047</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792024">
        <property type="protein sequence ID" value="CDM38233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QMV5"/>
    <dbReference type="STRING" id="1365484.W6QMV5"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004879718" evidence="1">
        <location>
            <begin position="23"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM38233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="65" mass="7208" checksum="5C97A0C639F5A382" modified="2014-04-16" version="1">MRATITIVFLFVIIVSLLIIDGEPTVVQIPSHYDGPAAVDALNWSQFAYTQYVTNTAYLCISVML</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>W6QNC5</accession>
    <name>W6QNC5_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="16 17">Phosphatidylethanolamine N-methyltransferase</fullName>
            <shortName evidence="16">PE methyltransferase</shortName>
            <shortName evidence="16 17">PEAMT</shortName>
            <shortName evidence="16">PEMT</shortName>
            <ecNumber evidence="16 17">2.1.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">cho2</name>
        <name evidence="19" type="ORF">PROQFM164_S02g001302</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15 16 17">Catalyzes the first step of the methylation pathway of phosphatidylcholine biosynthesis, the SAM-dependent methylation of phosphatidylethanolamine (PE) to phosphatidylmonomethylethanolamine (PMME).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16 17">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + S-adenosyl-L-methionine = a 1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11164"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64573"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="EC" id="2.1.1.17"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 16 17">Phospholipid metabolism; phosphatidylcholine biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="16 17">Endoplasmic reticulum membrane</location>
            <topology evidence="16 17">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16 17">Belongs to the class VI-like SAM-binding methyltransferase superfamily. CHO2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16 17">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.17" evidence="16 17"/>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QNC5"/>
    <dbReference type="STRING" id="1365484.W6QNC5"/>
    <dbReference type="OMA" id="RIWYSVG"/>
    <dbReference type="OrthoDB" id="4583at2759"/>
    <dbReference type="UniPathway" id="UPA00753"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004608">
        <property type="term" value="F:phosphatidylethanolamine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006656">
        <property type="term" value="P:phosphatidylcholine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.2840:FF:000006">
        <property type="entry name" value="Phosphatidylethanolamine N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03217">
        <property type="entry name" value="PEMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007318">
        <property type="entry name" value="Phopholipid_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016219">
        <property type="entry name" value="Phosphatid-EA_MeTrfase_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32138">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32138:SF0">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04191">
        <property type="entry name" value="PEMT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000383">
        <property type="entry name" value="PEAMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51598">
        <property type="entry name" value="SAM_CHO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 16 17" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 16 17" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11 16 17" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 16 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 16 17" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="13 16 17" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="14 16 17" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 16 17" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 16 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 16 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 16 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16 17">
        <location>
            <begin position="14"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16 17">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16 17">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16 17">
        <location>
            <begin position="352"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16 17">
        <location>
            <begin position="498"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="260"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="274"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="293"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00057332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU361122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CDM31152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="908" mass="102502" checksum="BD769E21E84CFE93" modified="2014-04-16" version="1">MVSQLLLPSEPKNFGDLVVLILLAGHILFLWALPKGAKIPVFAATYLFWRLAYNAGIGWLLHNQSHHKTLIRWAEKTKVFVNPATGKNPHPKLYNWIKRELETKIPQDYSFDNAPIEYNTWLVFRRLVDLILMCDFTSYCLFAIACGHQPVDESILMTVLRWSAGIVLVLFNLWVKLDAHRVVKDYAWYWGDFFYLIDQELTFDGVFEMAPHPMYSVGYAGYYGISLMAASYKVLLISIIAHAAQFIFLVLVENPHIDKTYNPPPPRKRSTTCADSSTLPTDLDTPTAPTPSEDQTPNATSSYSAKPPQSVHNLLGLHNLDLYRTTDSSIMLVQLLVFSITALTPSTPGYQLLFVVLAAASRIWYSVGIGYILRNQSNSKSWTRHFVKYGDTPQEAWNQWKGTYHLSMILCYSSFIAAVWKMYTFPADWNYGLVLFRHVLGAGLISLQIWTSVSIHESLGEFGWFYGDFFFDDSPKLTYNGIYRFLNNPERVLGLAGVWGAVLITSSGAIVFLALLSHILSLAFIQFVERPHMQKLYGRSLRQDAGLVKSLKRSLPPSLKQLHGSVDKMFDDSFEFIEEMLDNARPKLAAGVNTFVKDTTALFQKYPARVTISRIDADLAGFDARDYSLSVEGTSALSFEESEKNKGREGANARMPLDRRGDLKDLTFEYGAPIKVKWTAPLHHSKKDWIGLYRVTDNTSREVTRVSSQGRWVATNEGAYDNSTCEKGILTSDVVTSSSERQGQDPCEFASGEIVLSGNKLFWTEGVFELRYHHNGMHNVMAISRPFEIRIRRSDEDETISDGYSFVESAVEDALLPVVRNCFDRDPEIAPETVDEQFGSLVERDGKFAKRVVFAVHQMFGIELAAEVVKADGNVRNLAWRICNAKKVLAPYSMSRSNGTTTPVEESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W6QNK7</accession>
    <name>W6QNK7_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pleckstrin homology domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S06g000493</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792020">
        <property type="protein sequence ID" value="CDM37531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1365484.W6QNK7"/>
    <dbReference type="OMA" id="CEDAPCF"/>
    <dbReference type="OrthoDB" id="120976at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052394">
        <property type="entry name" value="LRR-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057334">
        <property type="entry name" value="PH_2nd_LRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24114">
        <property type="entry name" value="LEUCINE RICH REPEAT FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24114:SF41">
        <property type="entry name" value="PH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25353">
        <property type="entry name" value="PH_2nd_LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="146"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1038"/>
            <end position="1057"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1150"/>
            <end position="1195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1214"/>
            <end position="1234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1253"/>
            <end position="1291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1153"/>
            <end position="1178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1183"/>
            <end position="1195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1220"/>
            <end position="1234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM37531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="1291" mass="143246" checksum="431E6711A6701800" modified="2014-04-16" version="1">MAEMIGKRQRRKSLSVFSPSLTLSTPLRPAIHTRTPSDDTLTRDKKGRRNSSFFGRSHSPNRASDGSNNRRPGTAGSDTPVGIPSTPVMETPRPRRKSMQKKRTSVFGSLRSLHSWEDDETMSPSVGSMMDEQSMATPRNGIWSSAILHHGEVQTTGGMWRKKSHYLVLTDTHLIRFKNQGKAADVFACIPASYTRPAPSHRQSVASVSSLQDMQFMASGDSTAGIPLNSIIAVYMLEDARLSPSVEVAYLDERTNKATLVQMQTSDLQELNLWMVGIRQAAQMARANCPMPFSKGSIEYVTRMLEHERDYDPEVFRMFRVIQIASSKSITRSSSDDLTKLSPTGCYLAIGAHKLHLLPMQKTTNRSSVVSLSDWEAGTSFGLMNLTGLSMEYGDDSLHLIFRIPLKKSFNVFLASVHSVEIACWIRQHTEYLRPLWVRQPYEFVVPKELQNDDNFPPVALDEDYGCFDRTLVAYSASYDIDTSNIRYTIDQECEDAPCFRLLKPASPKTPRYNALELIAVMRALRYNEFFRSISFRGVNLDALQGLRDIHGVDSDVHLDRGGASVHIPGQTNLTVLSQEVRALALKSKWLRRLDFSYCLTRIPTPTLDKGTRDPGCGIPEAIFPVCRRELTSVDWVVLNGIKLGESDLDYLVDAASQRRSHLRALEVGDCGLSVHDLDLLLSTIVAQESTLEAINISGVQGRLNPDVLQQYIGYFGQIRKINLSRISRTSGTDPLITAEMLFNWRLEELALSRTVLNRETVDAIATYLASDRSRNLRVLRLDQCGLTGEDVAMFMQSMSSEPDSPRSLHLHVNENRIDNGCSHVFNAIANNQTPSHLSMRMIDFKKEDHFRELVDSLRKNSTLKFLDISKASLPYDASPETCRSLQVMLEENETLEALDISGDNAHLDVARFGIGLNLALTGLKKNTSLKVLRIEHQKLGLQGANTLASVLEENDTLREVHCENNDINLQSFTVLVNGLRCNRSLLTLSCMDRDRVLSLDKVRREVDNVRWEASNGNQSSGHSVRRSLYAAMTVGQGGQGHRLSKAPPPSVASALENSPFANHNVELVLQSLNERWDTEVSRLNRYLLRNYNIAHGIEEIDDDSASIGRPATAASLSTMFDNFKFDVSVSADEIRTPSLLDEPPAVIRLSEASDTPSQSSSYIESTSFQTRRISSNTRRPHTAAAAHFTPSSHSSSASLLALPVPAVPPAVKKAESVRSGRSSSSTASFSAGSTRSAYGVASSTLRGFLSGTALRERRRADAVRPSPVCVSDDKPPQLDWTPPKLDLGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>W6QNR1</accession>
    <name>W6QNR1_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">chitinase</fullName>
            <ecNumber evidence="3">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PROQFM164_S18g000003</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 18 family. Chitinase class V subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="3"/>
    <dbReference type="EMBL" id="HG792032">
        <property type="protein sequence ID" value="CDM38563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QNR1"/>
    <dbReference type="STRING" id="1365484.W6QNR1"/>
    <dbReference type="OMA" id="CATGCCN"/>
    <dbReference type="OrthoDB" id="73875at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00035">
        <property type="entry name" value="ChtBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.10">
        <property type="entry name" value="Endochitinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001002">
        <property type="entry name" value="Chitin-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018371">
        <property type="entry name" value="Chitin-binding_1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036861">
        <property type="entry name" value="Endochitinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF402">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00187">
        <property type="entry name" value="Chitin_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00270">
        <property type="entry name" value="ChtBD1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="Chitinase insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57016">
        <property type="entry name" value="Plant lectins/antimicrobial peptides"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00026">
        <property type="entry name" value="CHIT_BIND_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50941">
        <property type="entry name" value="CHIT_BIND_I_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="4 11" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9 12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004879736" description="chitinase" evidence="13">
        <location>
            <begin position="29"/>
            <end position="1257"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-1" evidence="14">
        <location>
            <begin position="28"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-1" evidence="14">
        <location>
            <begin position="105"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="15">
        <location>
            <begin position="158"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="41"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="59"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="122"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="127"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CDM38563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="1257" mass="139485" checksum="E3849C393CADF46C" modified="2014-04-16" version="1">MITIRPTGGALLWLLLISFCFIFTSANAQDCSALNTCATGCCNKGGYCGIGDDYCGSDCVANCDYEPECSVSKPCASGCCNSYGYCGLGPDFCADKVCVGNCDCKAECDPGKYGDYAESSKCPLNVCCSKFGFCGTTEEFCGKTKVKRPSCDKDGSLNRVVGYYEGWSPSRRCNTFYPEQIPVGIYTHLNYAFASIDPDTFEIVAATESEKKLMTRLTDLKKVDPDLKVFIAVGGWTFNDPGATQTLFSDLAASESNQKKFFKSLQSFMSIYDFDGIDLDWEYPVADDRGGQKKDFDNFPKFLANLKKSLKSTGGRDGVSITLPASYWYLQHFDIANLQKHVDFFNIMTYDMHGKWDLGSEWVSPMLDSHTNLTEITNALDLLWRNDIKSDKVVLGLAFYARVFTAADPSCMEPGCLFVSGGNAGKCSQEVGILLNSEIMDIMDKQSLQSTLDKEAAVKILKFDDNQWLTYENSDTFKLKADFARSQCLGGVMVWAVSHDLPQGNFSRALGDAVGREVKSLVNSGELASMEVKKTHPQCKWTNCFDDCPSGWSRVRRTDDGAREGEHMWDSTACSFGQHTFCCPPDAELPKCGWYTHNNGKCNSECPSGYTEIGSNIQYCSNDFNDYQAACCTTETPSMKLYSKCDWAGKPRKCDEECPSGKSEVALSTTGSGGVYCDVTSFKYTMNGQEGTSWEERSYCCSEEDDVEWSKCEWRDDIGLMLDKSYVDGYCLPGCPDEYVRVAIDQHGGGCKGDGGRAKCCLPKYSTVSKRSYTTREQSLDDLVKGFMDDPSCGADDYNLKRDLAGFEYSVGNTSLSDLSGTRTPTTLQRRSTTKQLDAIYTVAYALAVQFTVNAAYEEIWKKRVLPSYPHLTVKAIRNYLTTSEDWAEGGISYKLEKVLCAPSIFDSKFAERSIVSCACETSDCCDANDPDSCSDLDGDDDDSTALSKRVLDKRASRTFDVDLSDGGAHATITSWTYIVRGNIRGNNPILDEGYTYDDAEDCLNTQIALMSVSMANIGRYQVEHVVELNTVAFFLRDAANGVLRSGGVMRLGRISVTFVRQALMAPVLTNPPVMTGADQSLTPMTRIMHALGSLNNQADFNLLLNRLNNLKSRLWLSKTLIADEKMEKAISADDPNRALIHLREPLTIISYLNHLRVQPDMIDTFNTIHVEFGRADTYWVNAGHPNPQSQARWDEWVPDLLDSATQNVRTFVENWGDQMYRFWAVRTGDNVAQTLEIIMTLRRQAKSARINPNGLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>W6QP67</accession>
    <name>W6QP67_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histone acetyltransferase</fullName>
            <ecNumber evidence="2">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PROQFM164_S04g000770</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-lysyl-[histone] + acetyl-CoA = N(6)-acetyl-L-lysyl-[histone] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21992"/>
            <dbReference type="Rhea" id="RHEA-COMP:9845"/>
            <dbReference type="Rhea" id="RHEA-COMP:11338"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.48"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:21993"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="2"/>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QP67"/>
    <dbReference type="STRING" id="1365484.W6QP67"/>
    <dbReference type="OMA" id="DQLWVGQ"/>
    <dbReference type="OrthoDB" id="3361892at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032931">
        <property type="term" value="F:histone H3K56 acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051236">
        <property type="entry name" value="HAT_RTT109-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013178">
        <property type="entry name" value="Histone_AcTrfase_Rtt109/CBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016849">
        <property type="entry name" value="Rtt109"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31571">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31571:SF2">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE RTT109"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08214">
        <property type="entry name" value="HAT_KAT11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01250">
        <property type="entry name" value="KAT11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51728">
        <property type="entry name" value="RTT109_HAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3 11" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="324"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="471"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="324"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="349"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="481"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDM35889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="515" mass="56803" checksum="78C26D4ECDE23EE1" modified="2014-04-16" version="1">MAVDLADLLAKALPTGVEITVRHVSSTPTPCEALFAAAPGQVSEPTFCENHFLSVSIDANDDGETIIFGMEVMVYNTAHLTTIFISKADSTGLLHLLKLPRKVSVLRLVSNTFLSFLARTRQRPGVRLVVSLFARAQNQYLFPGSIENAEKHVLDDRGLIKWWCCVLDPILREHEPESALQETKALDQTVEAAKASATAYLIVPSCDRFETRNFFPPTAKTDAQDRPRWLNSYPLKQLYHDPSAPPRCLVPRFPDDPKTRFLVDLDSELPESKEGEPVAPNAGRWRSVRSLDQFWEMMSFRQECSAGRLVGFLWLVINPPGLMNSTSMESQTRGSSDNSTISGELKVENGSSQSEEIATLTTTDTSPKLPRDDGSNTVNPFDWPEAGRGQVVLSEPDYKTMMDSVLDHFYDEKEVIASTKLYVDQVSSLADELTWGKKVVGTNTTSSTTQPANTTANNVLDLGLIRKRKKSLGEDNMPAVNAQTPSGSGDTQPTPSEPTSVNVLNASLVRKKKKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W6QPM5</accession>
    <name>W6QPM5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ankyrin repeat-containing domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S04g000930</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM36049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QPM5"/>
    <dbReference type="STRING" id="1365484.W6QPM5"/>
    <dbReference type="OMA" id="WASEDKS"/>
    <dbReference type="OrthoDB" id="21416at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051637">
        <property type="entry name" value="Ank_repeat_dom-contain_49"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24180">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE INHIBITOR 2C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24180:SF45">
        <property type="entry name" value="POLY [ADP-RIBOSE] POLYMERASE TANKYRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="57"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM36049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="566" mass="63225" checksum="3A4508AC4C7849A3" modified="2014-04-16" version="1">MVPEVQDITALELYEAVGEGRIDRVESLLAAGVDPNARFDNLGSVFTGVAEDWASEDKSARPPLFNPDQTEQPSLRRATGESEGSCSYLDKPKATRLMNALLKHGADPYALYRQPILKYRYVRLYPGQTRDEEVDDEATDLDQICFARRGIMEKALRLERKRRNLEQGVYDPNRDEFISDFEGSLDDVIKYLDLPINYGVRSVIHALLEGGMFVQPIFDFLGDTLDVERRDPQGRTLFLTACRSRVGPDAATSGVYGGLSTINYDTGIHENPSLQPENPWREFEAKNSKACTGPTFLSFSIARGADLLAVDNYGNNALHLLFTYTDCAWIGLPPPIDTTLAHLIETCPSLINQPDKAGTYPLHLAIWQMNSIMIPARDSPASIYHFETAVDALLAANADTAVRDGRGNTVLHYLAGSRLGEKDRMGDEQRRFLRRFLEDGVDPRARNAEGMTALEIFCTVSYDEFGDEGFYDRYFAIGQYVIGQFEKAGYDIQETNSKGQTLLHLVAGLTAPEGMSWAAWPWFQLLRSKGLDPMAKDGEGKTPIDIAEENESINVWLQEERESMAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W6QQ59</accession>
    <name>W6QQ59_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Thiosulfate sulfurtransferase TUM1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">TUM1</name>
        <name evidence="4" type="ORF">PROQFM164_S09g000047</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792023">
        <property type="protein sequence ID" value="CDM38131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QQ59"/>
    <dbReference type="STRING" id="1365484.W6QQ59"/>
    <dbReference type="OMA" id="NNNWFAS"/>
    <dbReference type="OrthoDB" id="270167at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004792">
        <property type="term" value="F:thiosulfate-cyanide sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01448">
        <property type="entry name" value="TST_Repeat_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01449">
        <property type="entry name" value="TST_Repeat_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.250.10:FF:000001">
        <property type="entry name" value="Sulfurtransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.250.10:FF:000033">
        <property type="entry name" value="Thiosulfate sulfurtransferase TUM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045078">
        <property type="entry name" value="TST/MPST-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11364:SF27">
        <property type="entry name" value="SULFURTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11364">
        <property type="entry name" value="THIOSULFATE SULFERTANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Rhodanese" evidence="3">
        <location>
            <begin position="73"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="3">
        <location>
            <begin position="214"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM38131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="339" mass="38067" checksum="9BCE217CFF1FE00C" modified="2014-04-16" version="1">MAFTARSFASARLFRPNMSVSTGLHTQRNVSFSSYLVTPKQLNEALKKNPRTKISTSPRVIPLCAAWFMPNDPEGRKGIDSFRNSRIPQARFFDLDAIKDQDSPYPHMLPTCETFAEAMSELGIRRDDSVVVYDTAELGIFSAPRVGWTLRVFGHPNVHILNNYRLWIKDGLPTESGEPAVVEKSKYSVPTYDSRLVISFREMKELAFDYGKEGAEEIEILDARSYGRWAGTDPEPRPGLSSGHIPGSKSLPFQELLDPETKAYLPVEDLRKVFEDHKVDPNQTIISSCGTGVTASIIETALSEAEYGDPNLRRVYDGSWTEWAQRVKESDGLIKKVKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W6QQ81</accession>
    <name>W6QQ81_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AMP-dependent synthetase/ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S09g000067</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792023">
        <property type="protein sequence ID" value="CDM38151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QQ81"/>
    <dbReference type="STRING" id="1365484.W6QQ81"/>
    <dbReference type="OMA" id="KGKWFKT"/>
    <dbReference type="OrthoDB" id="2962993at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031956">
        <property type="term" value="F:medium-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05941">
        <property type="entry name" value="MCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201">
        <property type="entry name" value="ACYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201:SF28">
        <property type="entry name" value="ENZYME, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G01530)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="1">
        <location>
            <begin position="47"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="2">
        <location>
            <begin position="495"/>
            <end position="578"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM38151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="591" mass="64003" checksum="7083980C928F716D" modified="2014-04-16" version="1">MSGLLSLLSRTNARVCFTPRRMPLSARLLSTLPNTHIFRALQSHDPESLAVVHSISARSFTYGNLIADTVLAKEDLEQKAQGQLAGERIAFIAESSYDYVVMMLAIFASDAIALPLSPAFPVAELKYILDNSQAKMLLTTQKYANKGLEVVDKGLEHEPVFSIRRKLTEGASSSEAVTLQDLKQPSSGGLMLYTSGTTNRPKGVLIPHSAVAAQASSLLEAWKYTSDDRLLHLLPLHHIHGVVNAIVAPIVAGSSVEFMHPFNAEKVWKRLAAPFLPSNSSRSPVTFLTAVPTIYTRLMATFPELTPEYQKAAKEGISPQNLRLSISGSAALPTPTKAAWTKLSNGNVLLERFGMTEIGMAISCGLDVADRVDGSVGWPLPGVEARLTDLETGAVIPVEDKNSNGPERQGEIQIRGETVFDHYWDNEKATRESFVQSDDGGRPWFCTGDVAIRRVVDGAGSGASGDWARGPMYFIQGRKSVDIIKTGGEKVSALEVERELLSLPQITEAAVVGLPSEQWGQKIVAVVVLSPDAATSGHNGQPWGPLDMRRALKDSLAPFKIPHEMKVLEAIPRNAMGKVNKKALVKEVFGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W6QQB5</accession>
    <name>W6QQB5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">1,4-alpha-glucan-branching enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S09g000092</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792023">
        <property type="protein sequence ID" value="CDM38176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QQB5"/>
    <dbReference type="STRING" id="1365484.W6QQB5"/>
    <dbReference type="OMA" id="IYTYVAS"/>
    <dbReference type="OrthoDB" id="4368023at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00102">
        <property type="entry name" value="IPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00603">
        <property type="entry name" value="IPT_PCSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052387">
        <property type="entry name" value="Fibrocystin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002909">
        <property type="entry name" value="IPT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46769:SF2">
        <property type="entry name" value="FIBROCYSTIN-L ISOFORM 2 PRECURSOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46769">
        <property type="entry name" value="POLYCYSTIC KIDNEY AND HEPATIC DISEASE 1 (AUTOSOMAL RECESSIVE)-LIKE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01833">
        <property type="entry name" value="TIG"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00429">
        <property type="entry name" value="IPT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="IPT/TIG" evidence="2">
        <location>
            <begin position="17"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="IPT/TIG" evidence="2">
        <location>
            <begin position="104"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="IPT/TIG" evidence="2">
        <location>
            <begin position="187"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="IPT/TIG" evidence="2">
        <location>
            <begin position="270"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM38176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="351" mass="34138" checksum="AD168D899F2BEE8B" modified="2014-04-16" version="1">MLAADTGNVWTWNPTPTPTVTSLSPVSGPLSGGNVVTVTGTNLTGTISVTFGGVTAPFFVVLSSTALNATVPASTVAGTVDVVVTTPNGSSPINPGDQYTYIAGPAPTAVEPSADLISGGTQVAITGSGLTGTTSVLFGTIPGTAINVVSDSEVDVTTPSHAIGTVPITVTSTGGTNSSLTFTFEAPPIISTITPAFGSTAGGTAVSISGAGLSNTNEVLFGATPATAQAIISDNQLTATSPPGPAGLAPVTVVTDAAFSDAVPFTYLGAPTLAALSPTTGSRLGGNNVTLTGSGFTQATAVTFDTSGALFTVEDDGTITAVAPAHVALGAVPVTVTTPGGISGPQTYTYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W6QS85</accession>
    <name>W6QS85_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glyoxalase-like domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S02g002498</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QS85"/>
    <dbReference type="STRING" id="1365484.W6QS85"/>
    <dbReference type="OMA" id="MVKGDSQ"/>
    <dbReference type="OrthoDB" id="10249419at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07262">
        <property type="entry name" value="VOC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35006:SF3">
        <property type="entry name" value="GLYOXALASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_3G06020)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35006">
        <property type="entry name" value="GLYOXALASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G14830)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="2">
        <location>
            <begin position="2"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="320"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="409"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="506"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="416"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="432"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="449"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="465"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="506"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="519"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="544"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM32347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="572" mass="60656" checksum="422A78DBF3194013" modified="2014-04-16" version="1">MPVSHITLTVAHLPTSTSFYLSCLQPLGYQFIGRHDDYIGFGQKQGEPADFWMTETKPGCPPGAVHVAFPAPSKDAVGSFFISALKAGAKIHGEPKMRDSQSGYFSAAVIDFDGNSVEAVYRPGAASVISAASGPTMALLEGSSRSVVSRASSRASTAKAESIAPPRSEAMSERSVARSDTRSVARSEARSEARSEARSEARSDTKSRAGSKAPSVYERSAPSMVSRQFQGPPPPSYTMQSHAPPQSDDGSMAAKTIVGTLIGAAAGAAIAYAMVKGDSQSTAQEHEPMQFANSFPQLKAAAQSFFGNDDQQSQFRAIEAPAPPRSAYTTASNPRSTLTRSVTSKNPRASTIYDGSEYMENPRRASEGSIYSIPEDIPLRAIEYPPASNASQKRYACAPSTFISSYHEEKMRAPSSVHSSSTIKAPQSTTSRSHKSQHSTHSHAGKDNASVASSSRSARNIPLPTGSNATFYSSPSIHSRDGGKSHFSARNVPLPESVVDLDVASQVSPDDSISQVGLHPHRHRSHRSGSSKSSRADDRVSPADSVSQVSRASQRTAKEGSRAGSRRGSQAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W6QVB0</accession>
    <name>W6QVB0_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF952 domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S03g000221</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QVB0"/>
    <dbReference type="STRING" id="1365484.W6QVB0"/>
    <dbReference type="OMA" id="NDEGWDK"/>
    <dbReference type="OrthoDB" id="3335358at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.170.20">
        <property type="entry name" value="Protein of unknown function DUF952"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009297">
        <property type="entry name" value="DUF952"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34129">
        <property type="entry name" value="BLR1139 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34129:SF1">
        <property type="entry name" value="DUF952 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06108">
        <property type="entry name" value="DUF952"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM33497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="135" mass="15313" checksum="4775A29D2BC4B285" modified="2014-04-16" version="1">MASLISQPRYIYKIVPSTAPVREPIPERLTVSELDEADGFIHLSTAHQVGNTLKAFFTEEPLVYLLRIEYHRVVQDIRWESPDGKVSAPRPGEGLFPHLYNGLKLGRGEIESVAIWQNDEGWDKALTAGKPWLLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W6QY21</accession>
    <name>W6QY21_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phospholipase D/Transphosphatidylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S03g001171</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QY21"/>
    <dbReference type="STRING" id="1365484.W6QY21"/>
    <dbReference type="OMA" id="FHAKYMV"/>
    <dbReference type="OrthoDB" id="9997422at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030572">
        <property type="term" value="F:phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032049">
        <property type="term" value="P:cardiolipin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00138">
        <property type="entry name" value="PLDc_SF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025202">
        <property type="entry name" value="PLD-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21248">
        <property type="entry name" value="CARDIOLIPIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21248:SF22">
        <property type="entry name" value="PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13091">
        <property type="entry name" value="PLDc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PLD phosphodiesterase" evidence="2">
        <location>
            <begin position="277"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="2">
        <location>
            <begin position="565"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="627"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="633"/>
            <end position="642"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM34447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="674" mass="75561" checksum="D37ABE51F5F7460C" modified="2014-04-16" version="1">MDGIFHPWNLTGTLLNCVEFLKLAAATVSFSTVGIILFIRQPPSPNRVRCKMVPRKVYNMCQEPTVTWELALDSSQSPQDVFYNLYESRDASDILDRAEQSDVENELEWEALDELQKARTCGNFGSVETSDLFLKVYHDALCCLENNPMSGVVSPRLLGSTGVLPLTIVAPLPDLCRHLANCIARAEHEVFLGTNFWIHSDASTLVTNAIRELSKRAGERGQKVIMKLMYDRGDPRQAWENRLSVHEDQYVGGKVKLPAASEIPNVDLQVINYHRPVVGTFHAKFTVIDRRMALIQSSNIQDNDNLEMLSHIEGPIVDSFYDAALLSWGKALDPPFPLLNSPAKDAPIPCHVGRYDGISTERGDTVLPEHTTDSPHYDNDFEQEARRVNDSVYPQGDETRTQAVSRHLNTTIQLDTTGDAPEVDQDDMFNPYLVIPRHEPFAMALVNREPYGSPNHSSVHTPQNAAWLSAINNAQRSILIQTPNMNAEPLLEPILDAVRRGVVVSCYLCLGYNDAGELLPFQNGTNEMISNRLYKSLETDEEKSRLRICYYVGKDQTRPIHNSFKKRSCHIKLMIVDEQIAIQGNGNLDTQSFFHSQEVNVLIDSELVCRAWTELINRNQNTAKYGAASTKDGCWHDPKTDETPPGSMGPEKRRFSWARGAIGAVQRVRGVGGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W6QY92</accession>
    <name>W6QY92_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S03</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S03g001241</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QY92"/>
    <dbReference type="STRING" id="1365484.W6QY92"/>
    <dbReference type="OMA" id="AHWYEAQ"/>
    <dbReference type="OrthoDB" id="4121058at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="316"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="113"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="177"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM34517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="500" mass="54521" checksum="BD2EF00CFAC29CB0" modified="2014-04-16" version="1">MPPVTDGQFSFNIDTFYVTASGGQLHRRAAPAEIKALYDTATTDKSTPDHPGHWYEAQLLHYGLPPSKVKATAKMRLLKAVQDGALSVPKESLQIEKNLKKEWKKQDSEEPAKTNTKTTTTKTVTTKTITVSKTVASKTTESKTTASKAAAKPAAVKTAAPKAATSKAAISKKDPALKATASKATAAKATTTKAAPKAAAKPAAGKTATAKPATPKAASKKATAPKAAAPKATTTKSATSQSAPAKRKRASNAEETADKPQTAKRRVYGKKTQDNTNMPTNSYPGPSGWSEQPEQPEHQDAPPSYEIACRMDGEHPYDALGDQMDIDGPNEFGYGHYSESETCSEPPSPPRALKNTLGLLNGTYEVRSPRIECEWPDAVRGGIFLSLRLNGNEIWGTYELGAFKGVLWMPQRPMRPSFDRIPFKWRGRETGEGEMSFADDQDGWIEFLGDGDIVGMISCYGDVHFRGQRIDSSVRTASDLRNEWNRYNEEEYDRECRSRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W6QZ66</accession>
    <name>W6QZ66_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Major facilitator superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PROQFM164_S03g001559</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the major facilitator superfamily. DHA1 family. Polyamines/proton antiporter (TC 2.A.1.2.16) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QZ66"/>
    <dbReference type="STRING" id="1365484.W6QZ66"/>
    <dbReference type="OMA" id="TAFNCGS"/>
    <dbReference type="OrthoDB" id="446368at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000266">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF186">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="162"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="200"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="227"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="307"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="345"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="385"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="411"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="444"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="479"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="75"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="529"/>
            <end position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDM34832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="606" mass="66625" checksum="C7F5269501B35AF3" modified="2014-04-16" version="1">MAADSDPQVSDKIESSAPTKIPYWRLVFDQGVVTQEIIDHPYPGSGTDEDPFAVTWLPNDPRNPMNFSEVKKWTFTMLVAVATLAVSLVSSAYTGGIREIMVDFDIGQEVATLGVSLFVLGFAIGPLLWAPLSELFGRQVLFIGTYAALTAFNAGVAGSRNAWSIIILRFFAGSFGSSPLTNAGGVIADMFPARQRGIAMSLFAAAPFLGPIIGPIAGGFIGMSDGGWQWVMGFLAVFAGTVWIIGSLTIPETYAPVLLRRRAERLSKLSGQVYRSKIEIDQGKVSLKDSFKVSLSRPWILLFQEPIVFLLSLYMAIVYGTLYMMFAAFPIVYEQSRGWNQGVSGLAFLGIMIGMLSAVIYSLFDNKRYVEVSDRYNGFAPPEARLPPCLVASVAIPVGLFWFAWTNYPSIHFMVSIAAGVPFGFGMVLVFLSIMNYLIDSYTIFAASVLAANSVIRSLFGAAFPLFTTYMYNNLGIHWASSIPAFLALACVPFPFLFYKYGPAIRTRCKFAAQSEAFMRKIQEQAIPEPMEDEKEEYDRTEALPDGSLSSESQDGVEELANTERIRSRAHSLASIRTGASLARSVTYEGNPYDIDRVNTRESFKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>W6QZZ9</accession>
    <name>W6QZZ9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type DNA-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PROQFM164_S04g000023</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QZZ9"/>
    <dbReference type="STRING" id="1365484.W6QZZ9"/>
    <dbReference type="OMA" id="QESQCDT"/>
    <dbReference type="OrthoDB" id="5431381at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
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    </dbReference>
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        <property type="entry name" value="Sec_Metabolite_Reg"/>
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        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
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        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
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        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF49">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="9"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM35142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="681" mass="76709" checksum="AB9F3D26BAB26EDB" modified="2014-04-16" version="1">MQGARGFLSCASCRQRKLKCDRKEPCGNCATRGVDCVYATVLRSRNSAHTRHGNQHLSARIRQLEHLVGTSVAPGSPIQDAVDPSNIQELGFAVESREQVASDQAQSNDIEVKPGHMISNSGQVVEHIDRDHSAEPLDFPGQIQHEGGPMLLEGTHPSSDLAAVLCEIPPRDVADRLVSRYINSNEPSAVIIHKPTFGQEYARFWLEPHNFSAPWLSLLFGIMSMGVFFYVRSQDDLPNGLGSPRNAMDVFQRCSTECLIISKYSTIPTAHTMEALLLNIQNEYVRRRDAHLGVWVLCGIATRLAMRMGYHRDPEHYSQISTFNGEMRRRVWAIILQLDALTSCQLGLPSMIQESQCDTQLPHNLIDEDFDADTMRLPPSRPHTELTPVSYTIAKAQLLSVFRTIFNEVCLGRVEGYEEVMALDKRLLAVQSSIPPRFRMTSSEASVTTPSHLLIRRYNIELLFQKARCFLHRHHMTKAYQDPKFSYSRSSCIDAAMSILSHQMNIFKEVHPGGLLYRDKWFISSLEQHDFLLASMIVCLELGSRGSEGYAPSSSYDRNLGNYRSEELIEALKNSRQFWAEFKASSTEAQFGLDLISAMLQRVCTSQESQESSLGDFQSLGDLQNPIFSYDPSFLQEVEISPQNSYLEGIEAMLATPNNVDWGLWETFLQRSRTASDSQLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>W6R0T2</accession>
    <name>W6R0T2_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Homeodomain-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PROQFM164_S04g000323</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6R0T2"/>
    <dbReference type="STRING" id="1365484.W6R0T2"/>
    <dbReference type="OMA" id="SHADPMI"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051000">
        <property type="entry name" value="Homeobox_DNA-bind_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057939">
        <property type="entry name" value="TRF2_HOY1_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24324:SF5">
        <property type="entry name" value="HEMATOPOIETICALLY-EXPRESSED HOMEOBOX PROTEIN HHEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24324">
        <property type="entry name" value="HOMEOBOX PROTEIN HHEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24818">
        <property type="entry name" value="PH_TRF2_HOY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 5 6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4 5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="8">
        <location>
            <begin position="54"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="56"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="16"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM35442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="597" mass="64982" checksum="D4C4AFA05111F664" modified="2014-04-16" version="1">MSLLTEMHYPSNGAIAPSSSSPPASTPSPSTSSATTAHSSVTRRPPRKSTLTQQQKNNKRQRATQDQLVLLEIEFNKNPTPTAATRERIASDINMTERSVQIWFQNRRAKIKMLAKKSIETGEGCDSIPESMRHYLAMQFDPNKAGARDPFGRVGAYGQPSMYANETSPSGKVVISHFTCRSLTVGSWRRIGQNAMDLVVFYSPDKACMTYYINNDAAGYKIEYPFAYIKNITLETGDPSPGPNGEPPRPGGLVVELNRPPHFYMDSSNSGGFYQCGDFTEEQQASQIMVHHLGGHPKVLSVQLAKLVSLESFQNRLAYNNSSFAVPAAMSPPFIQRPASQPNHFAAPTYMNLYQDSNHLGFNMPAARGHKRQRSRSVPVAVDISTFQSPMSSFHVPPPPPFNHTEAGIYAPVPQSVHHLPTDLRIDTQGYGLDFHNPMSATTTGSPPDFASPMYSNAGQDDSTPIASMAPQFNVPFVSGGSTDASAMGSHAPSPYSSMSPADPLIANHSPPLSSMSHGSSDMYGFSHDQQTSFDDGLSMNDMYSKHHVNYDVSHESPSFELPMHGLSAHPSPGMGDYSHGMANLDEINSQGMPTGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W6R386</accession>
    <name>W6R386_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PRISE-like Rossmann-fold domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S05g000085</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6R386"/>
    <dbReference type="STRING" id="1365484.W6R386"/>
    <dbReference type="OMA" id="TWIETYR"/>
    <dbReference type="OrthoDB" id="1731983at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd08948">
        <property type="entry name" value="5beta-POR_like_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055222">
        <property type="entry name" value="PRISE-like_Rossmann-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32487">
        <property type="entry name" value="3-OXO-DELTA(4,5)-STEROID 5-BETA-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32487:SF0">
        <property type="entry name" value="3-OXO-DELTA(4,5)-STEROID 5-BETA-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22917">
        <property type="entry name" value="PRISE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PRISE-like Rossmann-fold" evidence="1">
        <location>
            <begin position="9"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM36252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="384" mass="43991" checksum="DB53862B63E59C17" modified="2014-04-16" version="1">MGPPTSKVALVTGANGISGFSVIEHLVRQSKEEWSKIVVTSRRPLPNAWIDPRVEFLAIDFLDPVEDIIAKMKDICANVTHAFFTSYVHSDDFKLLREKNVPLFRNFLDATISSCNKLQNVSLQTGGKYYGVHLGPVKVPLEESFPRYDDQGYNFYYNQEDYLKELQARDRTWSYSIIRPNAINGYAPNANGMSEVLTIIIYMLICRELGQPANFPGNEYFWNSIDDNSYAPSVADLTVFAASHENCKNEAFNHVNGDIFVWKYIWQDFAAYFGIEVPEPNFVKARRADTLSNEIDMVEWAKDKRGVWETVVRKYGGKVETFDCGTWGFFNWASGKSWLTISSINKARQFGWQRNDRTFDTWIETYRSFENAGALPSRAALLRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W6R3G8</accession>
    <name>W6R3G8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Pseudouridine-5'-phosphate glycosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PROQFM164_S05g000180</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6R3G8"/>
    <dbReference type="STRING" id="1365484.W6R3G8"/>
    <dbReference type="OMA" id="FNCIIAT"/>
    <dbReference type="OrthoDB" id="198885at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004730">
        <property type="term" value="F:pseudouridylate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01941">
        <property type="entry name" value="YeiC_kinase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1790.10">
        <property type="entry name" value="Indigoidine synthase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01876">
        <property type="entry name" value="PsiMP_glycosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022830">
        <property type="entry name" value="Indigdn_synthA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007342">
        <property type="entry name" value="PsuG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42909:SF1">
        <property type="entry name" value="CARBOHYDRATE KINASE PFKB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42909">
        <property type="entry name" value="ZGC:136858"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04227">
        <property type="entry name" value="Indigoidine_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110581">
        <property type="entry name" value="Indigoidine synthase A-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="6">
        <location>
            <begin position="395"/>
            <end position="619"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM36347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="793" mass="83711" checksum="8886F87F380478D9" modified="2014-04-16" version="1">MLSHTMFASRAALRSGCLRGTQLLSARRYHGLAQSRFFKVSDEVRDAIATGKPVVALETTIYTHGFPYPDNIALAALLESVVRANGGVPATIGILGGVAKVGLSTEELIELASTAQEKSALKVSRRDLGYICGLGMVGKKMHGGTTISGTMILSELAGIKIFGTGGLGGVHRGAESSMDISADLTELGRTPVTVISSGCKSFLDIPRTLEYLETEGVCVGTFADGRDGAVDFPAFFTRESGIRSPRVIQNEAEAAAIVYAQSKLPVSSGIHFANPVPLEHSIPKAEMDIVIEEAIRLSHVEGYHGSDNTPFVLAKIKELSGGKSVVANRALIESNVKRATLVAVELAKLEQADLGTGSRHMPSIPDVAFPSQVASQVEDFPEPATEAPITPTLKADVVVAGSLAIDLSCDYTPFGDELTQVAPVPHTSNPAIIGQSLGGVGHNVAIAASYVGSDVIFCSVVADDLSGRAALSTLEKEGLSTAGIQVLAATASTRTAQYIAINDTKKDLLIAMADMGIVELPESELDFDGFWEPLLERTKPNWVVVDANWRPDVMAKWSAVARKHGARVAFEPVSTAKSRRLFGTGATIGPNQIVPNDAISLACPNRLELTAMFNAAREASLFESAEWWHLINSMNMSPTGSRQQLIALTSLSLVDEGIPQQTVQLLPFIPCIVTKLGGAGSLLTQLLPPGDPRLTDPKSAPYILSRAWGPDLPFGGVYMRLFSPDTILDAKDIVSVNAAGDTLLGVVVAGLSKDPSVRVEDVIPIAQEASRKTLASAGGVSKELGELRGLLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W6R497</accession>
    <name>W6R497_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acyl-CoA N-acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S05g000465</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6R497"/>
    <dbReference type="OMA" id="VDCYAGG"/>
    <dbReference type="OrthoDB" id="2821191at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="13"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM36632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="186" mass="20340" checksum="9846033918A7CF48" modified="2014-04-16" version="1">MASNPIKNGVHDITIVRGTADAVPAVLHLLDTAVQWLVSHNRTGQWGTASFSENPQRAEQLKEFATTGHGLWLAQTMNGEEPGVVVGALALGDKMPYVTPVSEPELYVRLLVTDRQCAGSQIGRRLLDHARDLARKAGVSLLRVDCYAGGDGKLIQYYESQGFERFETVNVKGEWPCQVLAQRLVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>W6R4U7</accession>
    <name>W6R4U7_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="12">CWF complex protein sap62</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">sap62</name>
        <name evidence="12" type="ORF">PROQFM164_S05g000675</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SF3A2 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6R4U7"/>
    <dbReference type="STRING" id="1365484.W6R4U7"/>
    <dbReference type="OMA" id="EFWIQIM"/>
    <dbReference type="OrthoDB" id="10250970at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.2690:FF:000002">
        <property type="entry name" value="Splicing factor 3a subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2690">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000690">
        <property type="entry name" value="Matrin/U1-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052092">
        <property type="entry name" value="SF3A2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031781">
        <property type="entry name" value="SF3A2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23205">
        <property type="entry name" value="SPLICING FACTOR 3A SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23205:SF0">
        <property type="entry name" value="SPLICING FACTOR 3A SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16835">
        <property type="entry name" value="SF3A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01050">
        <property type="entry name" value="CactinC_cactus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50171">
        <property type="entry name" value="ZF_MATRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Matrin-type" evidence="11">
        <location>
            <begin position="54"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="73"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="80"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDM36842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="234" mass="27046" checksum="965D86A5C5C7D925" modified="2014-04-16" version="1">MDYQNRAGSKFGGGGVASQSATNADRRERLRRIAMETMDIEKDPYIFKNNVGTFECRLCLTVHQNDGSYLAHTQGRKHQTNLERRAAREDREGKKDQSTLPGVAGVQVKKQLIKIGRPGYKITKIRDPLTRQNGMLFQLQFQEITPGVKPRVRFMSAFEQQVETPDKNYQYLVVAAEPYQNSAFKIQAKEIDRRDENYWTWFDEDSKEFWIQILFKTEREEIFSGVPGLAPSQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W6R559</accession>
    <name>W6R559_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Nucleotide-binding, alpha-beta plait</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PROQFM164_S05g000795</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6R559"/>
    <dbReference type="STRING" id="1365484.W6R559"/>
    <dbReference type="OrthoDB" id="1049195at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050374">
        <property type="entry name" value="RRT5_SRSF_SR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003">
        <property type="entry name" value="RNA RECOGNITION MOTIF RRM DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="152"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="51"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="200"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="59"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="84"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="100"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="112"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDM36962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="222" mass="25253" checksum="EEE855A831E77E2B" modified="2014-04-16" version="1">MGTFSRVLWIITLCFFVSLYYSFVTLICLVHSKGPRFSADSLIRPADVYRPYQRERSRSPRRRSSRSPPRRARRSYSPRSRSRSRGDREEYRRPERRSRSPLSASGAATGPPGSGSPFGGRSGYTPARFEDRAAKENMMQTVRDSSQQDRRVYVGNLSYDVKWHHLKDFMRQAGEVLFADVLLLPNGMSKVGDCGICNQGPSTKRREYAQQPEPDGSPCLCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W6R695</accession>
    <name>W6R695_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Intradiol ring-cleavage dioxygenase, core</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S06g000283</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792020">
        <property type="protein sequence ID" value="CDM37322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6R695"/>
    <dbReference type="STRING" id="1365484.W6R695"/>
    <dbReference type="OMA" id="KTWLRGI"/>
    <dbReference type="OrthoDB" id="121380at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016702">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03457">
        <property type="entry name" value="intradiol_dioxygenase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.130.10">
        <property type="entry name" value="Aromatic compound dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015889">
        <property type="entry name" value="Intradiol_dOase_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34315">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34315:SF1">
        <property type="entry name" value="INTRADIOL RING-CLEAVAGE DIOXYGENASES DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49482">
        <property type="entry name" value="Aromatic compound dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004880732" evidence="2">
        <location>
            <begin position="22"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="347"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="365"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM37322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="387" mass="41303" checksum="8F9EE3F2216F36E5" modified="2014-04-16" version="1">MVHLASIVAVGLTALTGIVSAHPGHDVKAEAAERAAFLKEASVHSRSLAQCTSHLQRRGHQSRNVARRHTSVKNIRRRLGLQHTNHFLKARSDDALDTSHHSNLTSVDYSTDPEVLFGAEATCILGPEVTQGPYYVTGELVRKNIAESQEGIPLYLDIQLINTNTCEPIPQLYTDLWHCNSTGVYSGVVASGNGNSNDSTNLDTTFNRGIQKSNRDGVVQFQTTFPGHYTGRATHIHVLAHPANETRVLANGTISGLYTTHSSHVGQIFFDQDLITAADEVAPYSTNTQEVTTNADDSILGEELDVIDPFMEYIYLGDDISEGIFAWITVGLDPTQDTTVTPAAYYTEDGGVENENAGAGGGSGAPPDDGASSGSSSSSSSSSTTAA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2026-01-28" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W6R6H0</accession>
    <name>RUSD_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Short-chain dehydrogenase/reductase rusD</fullName>
            <ecNumber evidence="7">1.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Roquesalins biosynthetic cluster protein D</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rusD</name>
        <name type="ORF">PROQFM164_S06g000374</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>FM164</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2025" name="Org. Lett." volume="27" first="2433" last="2437">
            <title>Formation of N-Hydroxyethylisoindolinone Derivatives in Fungi Requires Highly Coordinated Consecutive Oxidation Steps.</title>
            <authorList>
                <person name="Li Z.H."/>
                <person name="Dai Y."/>
                <person name="Zhou J."/>
                <person name="Yang L."/>
                <person name="Li S.M."/>
            </authorList>
            <dbReference type="PubMed" id="40029258"/>
            <dbReference type="DOI" id="10.1021/acs.orglett.5c00328"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>PATHWAY</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Highly reducing polyketide synthase; part of the gene cluster that mediates the biosynthesis of the N-hydroxyethylisoindolinone derivatives roquesalins (PubMed:40029258). Within the pathway, the short-chain dehydrogenases rusB and rusD, and the oxidoreductase rusC assist the highly reducing polyketide synthase rusA to assemble stachysalicyloid D from one acetyl-CoA starter unit and 5 malonyl-CoA elongation units (PubMed:40029258). The biosynthesis begins with the roquesalin backbone assembly by the cooperation of the highly reducing polyketide synthase rusA, the short-chain dehydrogenase rusB, the oxidoreductase rusC and the short-chain dehydrogenase rusD and released as stachysalicyloid D. Stachysalicyloid D can be reduced to stachysalicyloid B by an unknown enzyme and the FAD-linked oxidoreductase rusE oxidizes stachysalicyloid B back to stachysalicyloid D to ensure the oxidation state of the backbone for further reactions. After the oxidation at C-8 by the membrane-bound cytochrome P450 monooxygenase rusF, the widely distributed ethanolamine in the cell membrane can be loaded onto the alkyl salicylaldehyde scaffold to form an isoindole intermediate. Hydroxylation at C-10 catalyzed by the FAD-linked oxidoreductase rusG completes the biosynthesis of major pathway product roquesalin B (PubMed:40029258).</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.-" evidence="7"/>
    <dbReference type="EMBL" id="HG792020">
        <property type="protein sequence ID" value="CDM37412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6R6H0"/>
    <dbReference type="STRING" id="1365484.W6R6H0"/>
    <dbReference type="OMA" id="FAWRTIW"/>
    <dbReference type="OrthoDB" id="2102561at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000140">
        <property type="term" value="F:acylglycerone-phosphate reductase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019433">
        <property type="term" value="P:triglyceride catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05374">
        <property type="entry name" value="17beta-HSD-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44169">
        <property type="entry name" value="NADPH-DEPENDENT 1-ACYLDIHYDROXYACETONE PHOSPHATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44169:SF3">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE SRDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0521">NADP</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000462856" description="Short-chain dehydrogenase/reductase rusD">
        <location>
            <begin position="1"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="145"/>
        </location>
    </feature>
    <feature type="active site" description="Lowers pKa of active site Tyr" evidence="2">
        <location>
            <position position="149"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="6"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="L0E2Z4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="O93868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="40029258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="5">
        <source>
            <dbReference type="PubMed" id="40029258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="6"/>
    <evidence type="ECO:0000305" key="7">
        <source>
            <dbReference type="PubMed" id="40029258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM37412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="284" mass="31508" checksum="A307570484A8A157" modified="2014-04-16" version="1">MKSVLITGCGKGGIGEALALQYRARGCTVLATVLPWESREHLSSVGIACFELDVTKDDSVRALRKAVEEKIGDRLDILVNNAGICYTMTAIDTDVKQVQQMFDVNLFGPIRMVNIFHPLLILAKGCVVNIGSVGGVVPYMYGSSYNASKAALHHWGNTLRVEMSPLGVRVINVISQIISGNIGTNILDRDSSRTLPPDSFYAPLQTEFQAHVQRVPDTTDRMVYAKSVVQQSLRACPPAWHWVGNTSTLVWFMDIFAFRTIWDYVLWPVFSLGKLKRAMKSRSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W6R783</accession>
    <name>W6R783_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Myb-like DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S07g000050</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792021">
        <property type="protein sequence ID" value="CDM37702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6R783"/>
    <dbReference type="STRING" id="1365484.W6R783"/>
    <dbReference type="OMA" id="WACHKIS"/>
    <dbReference type="OrthoDB" id="3944408at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054505">
        <property type="entry name" value="Myb_DNA-bind_8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22980">
        <property type="entry name" value="Myb_DNA-bind_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb-like DNA-binding" evidence="2">
        <location>
            <begin position="29"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM37702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="115" mass="12845" checksum="91710DFDAF27D0D9" modified="2014-04-16" version="1">MAPTKSTPASKAGKSPSKPKEPRDSDLKKQLLFLWACHKISGVQVDAPAVARHFGITNHAARMRLDRLRKKLDEMEASTRSDDDTRAIKDKDDDCKAQTKQTEVDSEDECDTMSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W6R7K7</accession>
    <name>W6R7K7_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">deoxyribose-phosphate aldolase</fullName>
            <ecNumber evidence="2">4.1.2.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">2-deoxy-D-ribose 5-phosphate aldolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">deoC</name>
        <name evidence="10" type="ORF">PROQFM164_S07g000160</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>2-deoxy-D-ribose 5-phosphate = D-glyceraldehyde 3-phosphate + acetaldehyde</text>
            <dbReference type="Rhea" id="RHEA:12821"/>
            <dbReference type="ChEBI" id="CHEBI:15343"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="ChEBI" id="CHEBI:62877"/>
            <dbReference type="EC" id="4.1.2.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.4" evidence="2"/>
    <dbReference type="EMBL" id="HG792021">
        <property type="protein sequence ID" value="CDM37812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6R7K7"/>
    <dbReference type="STRING" id="1365484.W6R7K7"/>
    <dbReference type="OMA" id="AAYCVNP"/>
    <dbReference type="OrthoDB" id="70823at2759"/>
    <dbReference type="UniPathway" id="UPA00002">
        <property type="reaction ID" value="UER00468"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004139">
        <property type="term" value="F:deoxyribose-phosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009264">
        <property type="term" value="P:deoxyribonucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046386">
        <property type="term" value="P:deoxyribose phosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00959">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000198">
        <property type="entry name" value="Deoxyribose-phosphate aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00114">
        <property type="entry name" value="DeoC_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011343">
        <property type="entry name" value="DeoC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002915">
        <property type="entry name" value="DeoC/FbaB/LacD_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028581">
        <property type="entry name" value="DeoC_typeI"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00126">
        <property type="entry name" value="deoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10889">
        <property type="entry name" value="DEOXYRIBOSE-PHOSPHATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10889:SF1">
        <property type="entry name" value="DEOXYRIBOSE-PHOSPHATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01791">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001357">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01133">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0704">Schiff base</keyword>
    <feature type="active site" description="Schiff-base intermediate with acetaldehyde" evidence="9">
        <location>
            <position position="164"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="9">
        <location>
            <position position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00056337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001357-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDM37812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="260" mass="28311" checksum="2EF43C1C7523F18A" modified="2014-04-16" version="1">MAQVNTLAVSLHQLAKMIDHSLLHPTVTDGDVIAGLRVAKEYNVATACVKPYHIQLAKQELQDTDVEICAVIGFPHGNSTTEIKVQEATAAVEAGSHEIDMVVNIGKVLGGDWGYVSQEIEQINTAVVQKGAILKVIFETDYLKPEHIVHLCKICTESSVAFVKTSTGYGFVKQADGSYNYKGATVKHLRLMRQYSGPDVQIKAAGGVRTLDDLLHVMSLGVTRIGATATVAIIEDAKKRGIGMDRIEVEFKPMKEDSHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W6R900</accession>
    <name>W6R900_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Calcineurin-like phosphoesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S11g000005</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792025">
        <property type="protein sequence ID" value="CDM38302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6R900"/>
    <dbReference type="OMA" id="FTHHSPV"/>
    <dbReference type="OrthoDB" id="550558at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37844">
        <property type="entry name" value="SER/THR PROTEIN PHOSPHATASE SUPERFAMILY (AFU_ORTHOLOGUE AFUA_1G14840)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37844:SF2">
        <property type="entry name" value="SER_THR PROTEIN PHOSPHATASE SUPERFAMILY (AFU_ORTHOLOGUE AFUA_1G14840)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="1">
        <location>
            <begin position="6"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM38302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="272" mass="30580" checksum="0F6F7BF5013E8024" modified="2014-04-16" version="1">MSTFQILSDLHLENPSAYDVFNISPKAPHLALLGDIGVVNDAGFITFIETQLRQFQIVFFLLGNHEPYDSTWEETKQLLHQFSASVDRRRSTEQDGDSETMGSFIFLDQTRYDLSPEVTVLGCTLFSRVSEAHKEHVSYGLNDFYNIKDWTVDDHTAAHEADLGWLNGQVSHIASSEPHRKIVVFTHHSPVTQDPRAVDPRHVNSSLSSGFASDLSGHEVWKSPLVKLWAFGHTHFNVSYIEEGTKKMVVSNQRGYYLSQAPGFDGELVVGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W6PRC9</accession>
    <name>W6PRC9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g000095</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PRC9"/>
    <dbReference type="OMA" id="RVGEWWR"/>
    <dbReference type="OrthoDB" id="4338269at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM26286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="124" mass="14663" checksum="EE6E6C92B879794E" modified="2014-04-16" version="1">MDTSGSEYEQPLLPSSIRKRKRSAEHDSSRARKKRKPALDDLHKLLVTYHGLQQMQRELNEQLAVCNRQIAKHKFGSASGKSRRRRGRGRPYPRVKSPLRGVLRVEEDMPTFWGRVGEWLRRWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W6PRE2</accession>
    <name>W6PRE2_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S01g000254</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PRE2"/>
    <dbReference type="STRING" id="1365484.W6PRE2"/>
    <dbReference type="OMA" id="AKFYQLY"/>
    <dbReference type="OrthoDB" id="19806at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070822">
        <property type="term" value="C:Sin3-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038919">
        <property type="entry name" value="STB2/STB2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059025">
        <property type="entry name" value="STB6_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31011">
        <property type="entry name" value="PROTEIN STB2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31011:SF2">
        <property type="entry name" value="PROTEIN STB2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25995">
        <property type="entry name" value="STB6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STB6-like N-terminal" evidence="2">
        <location>
            <begin position="37"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="435"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="502"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="530"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM26445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="837" mass="94082" checksum="058D39E4B6C922B5" modified="2014-04-16" version="1">MQVNAPNVPPVDRTDSLPSEAASHATGAERPSPQGHQRIVFTDAVALRYLEEDPSTDVLQRRVTLQGYEIYIVEQWACSRVHPTFIISTYTGDPSHTVIVGVLSVPTNETTWSPRLRMYFDAMKQCHARRKETPLGTVMVTDLASFPSALSLIPIPNGDIKKHREDFIVNEDLKRLGCAGRAGLKLQHPSAATEAKFHQLYRTSERVPLYNAVMELVRQCQIALMVFDKLAPEYVDGLLCDVTEAAISDWWTDIGTDLYNIEPSDSSLGPTSVAALLGTLLGARNRLHAYGAPVGKDAFDFHSLKRGIGGFQKSQKMKRSRRLDRLTLDRLHRVTAKAANAEGWTDAVKSTMAELSGQGGEMVMGMVRGRDKGGIADIETLDLDTFVQCCNGERAKWLWLGKPRKSGVEDGFTRGTGSDMMFTTDEQGGYVWTSRRKHSTEDLHAERASSALDRSWKTPEPPAEEKDHRKKGVSGRVSDARAGLGRFKDAVGRQRHHHQHHSSRDSSEVTHDLAYRPSIDSDNEAPSTKTRTDSGFRSERKISNDIEKLIEEEEKPQLSPFSESERKAPEIHIEPVPEDEPETQAQDWPIVQQAPIIEEESDMERVISRSTAASTDRDRDGSISGIAVMALRRPQSCEAFQSLESELERRDNFCARHLSFSIVEEVVFKWEPLGGKPTVKETNNLDEAIVQEDMLASEGRIFSSRIQELSQHTVPWVERQVDSVEGLNQLLCDRHEELNSVYLERFGDYQRLRERSSDILIDESHHLADGVKRVELLGAKLDYELHVLESKVEDMEAGLSDFDRHIVNVEMRIKALVKGEEQHDTSWTAWIARSMGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W6PRS9</accession>
    <name>W6PRS9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g000384</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PRS9"/>
    <dbReference type="STRING" id="1365484.W6PRS9"/>
    <dbReference type="OMA" id="KAMLDHW"/>
    <dbReference type="OrthoDB" id="4115400at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="324"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="432"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="37"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="464"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="510"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="586"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="615"/>
            <end position="629"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM26575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="760" mass="84427" checksum="EFEAB08A1E94DA8E" modified="2014-04-16" version="1">MAPIPRADLDVDNPSSDVGDSQDSPLRRQFSEPFRPQSTSTQISQSPEPVPRRLKCDYCGKLLMLPNDAGISKEDVLKDHVNEVHPKTIRFSGYDGAEDGADDTYDENGDLQDDDAIEHDEPMVQATKPEDGEAQDEEGEEIAVELITDDNNGIQPTTIQVNASQIPETKRDLLDWLSNPRTGYPEEYRLREAQWRRPDVKKRLERFWKVHDTDEFSPNYIQEAAKCESTWDNAFHDPSKTRKRDAPEPAPHPLPYKKSKVEKGQFLEVQAQELDELVSMLRNPENHTPEELYALTQTAAFTLRTLQDEYLALDNLYLKAHRHKRDEPSYQTKRHQMQGHKKKGGAPLANVNEDKLDFEEKKEAMLYGYKHNYFPGNTPLVPIRTQQDPFVQGGFVPTPAQARKMIAKSKESGDLNPDGWATMKKHGLEYHAQMYEPRREPLVPKVTRKRKAAEVEVPTKTTESEETQNESAGGDETDDDNHPAKRRARGRGGKTVVTDATHSDANSRKSSGRGRGRGRGRGLGRLGSSRATFEVTPAPTQISSRGRGRRGASSLASSSIPPAETSFPAVEPMAAASPVESTSTSAKKEALSAEAIEEARRQKIANSKNPKRTKAMLDHWDRFNREGRIRNPKRSKAQIEQDRTVDGAADEVPKPTGPGRRKRSPSLAPLAGNLAPKGPIGLPSMASVQAQQQPMPPTLPPMGVVPHYGPGPVNPFAAAASVAPMAQLGQPMPPQYAPFPYVQYHGMGPLPGHNPRDPRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>W6PRU8</accession>
    <name>W6PRU8_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Polyadenylate-binding protein</fullName>
            <shortName evidence="14">PABP</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PROQFM164_S01g000290</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Binds the poly(A) tail of mRNA. Appears to be an important mediator of the multiple roles of the poly(A) tail in mRNA biogenesis, stability and translation. In the nucleus, involved in both mRNA cleavage and polyadenylation. Is also required for efficient mRNA export to the cytoplasm. Acts in concert with a poly(A)-specific nuclease (PAN) to affect poly(A) tail shortening, which may occur concomitantly with either nucleocytoplasmic mRNA transport or translational initiation. In the cytoplasm, stimulates translation initiation and regulates mRNA decay through translation termination-coupled poly(A) shortening, probably mediated by PAN.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 14">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the polyadenylate-binding protein type-1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PRU8"/>
    <dbReference type="STRING" id="1365484.W6PRU8"/>
    <dbReference type="OMA" id="QQPGFMP"/>
    <dbReference type="OrthoDB" id="19742at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12378">
        <property type="entry name" value="RRM1_I_PABPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12379">
        <property type="entry name" value="RRM2_I_PABPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12380">
        <property type="entry name" value="RRM3_I_PABPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12381">
        <property type="entry name" value="RRM4_I_PABPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1900.10:FF:000004">
        <property type="entry name" value="Polyadenylate-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000003">
        <property type="entry name" value="Polyadenylate-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000355">
        <property type="entry name" value="Polyadenylate-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000384">
        <property type="entry name" value="Polyadenylate-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1900.10">
        <property type="entry name" value="c-terminal domain of poly(a) binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036053">
        <property type="entry name" value="PABP-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006515">
        <property type="entry name" value="PABP_1234"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002004">
        <property type="entry name" value="PABP_HYD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034364">
        <property type="entry name" value="PABP_RRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045305">
        <property type="entry name" value="RRM2_I_PABPs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01628">
        <property type="entry name" value="PABP-1234"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24012">
        <property type="entry name" value="RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00658">
        <property type="entry name" value="MLLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00517">
        <property type="entry name" value="PolyA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63570">
        <property type="entry name" value="PABC (PABP) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51309">
        <property type="entry name" value="PABC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="10 13 14" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="9" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="RRM" evidence="16">
        <location>
            <begin position="45"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="16">
        <location>
            <begin position="133"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="16">
        <location>
            <begin position="226"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="16">
        <location>
            <begin position="329"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="PABC" evidence="17">
        <location>
            <begin position="637"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="360"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="608"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="714"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="377"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="15">
        <location>
            <begin position="608"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="626"/>
            <end position="639"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU362004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CDM26481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="740" mass="80455" checksum="DBEFF02A5E70DF40" modified="2014-04-16" version="1">MSAEAPATAPVTDNVVAATPEANGAPVEATSEAAGDAANNQPHSASLYVGELDPSVTEAMLYELFSSIGQVASIRVCRDAVTRRSLGYAYVNYNNTADGERALEDLNYTLIKGKPCRIMWSQRDPALRKTGQGNVFIKNLDNAIDNKALHDTFAAFGNILSCKVAQDEFANSKGYGFVHYETAEAANNAIKHVNGMLLNDKKVFVGHHISKKDRQSKFEEMKANFTNIYIKNIDLEITDDEFRVMFEAFGEITSATLSHDQDGKSRGFGFVNYANHESAEAAVAEMNEKDVKTQKLYVGRAQKKHEREEELRKQYEAARMEKASKYQGVNLYVKNLTDDIDDEKLRDLFTPYGTITSAKVMRDAAERSPSPEAEEKEADKETKDSEEKEVKTEESTEAKTEEPTEEKKTEEEGEDTEEKKTEKKAFGKSKGFGFVCFSSPDEASKAVTEMNQRMVNAKPLYVALAQRKDVRRSQLEASIQARNTIRQQQAAAAAGMPQPFMQPAVFYGAGQQGFMPPGQRGGMPFAPQGGMPMPNMPAGRPQYPGPFPQGGRGMPPNQQLPPNFQGMPMGMQAPGGIPNGMGYPMPQAFGRGGGGRGVPGMPMNMRGGPGFGRGGPQMGRGGGRGQPAPGGQPAGGEPASANQALLTAPPAQQKQMLGEALYPKIQAQQPELAGKITGMLLEMDNAELLGLLDDEEALRGKVDEALNVYDEYMKNKGDGETTEPKPQEAAKEAPVEENKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W6PT00</accession>
    <name>W6PT00_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RNA polymerase sigma factor 54, DNA-binding</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S01g000814</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PT00"/>
    <dbReference type="STRING" id="1365484.W6PT00"/>
    <dbReference type="OMA" id="WIRRINS"/>
    <dbReference type="OrthoDB" id="5392716at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025676">
        <property type="entry name" value="Clr5_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058913">
        <property type="entry name" value="Integrase_dom_put"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46791:SF5">
        <property type="entry name" value="CLR5 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46791">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14420">
        <property type="entry name" value="Clr5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24764">
        <property type="entry name" value="rva_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Clr5" evidence="1">
        <location>
            <begin position="18"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase core" evidence="2">
        <location>
            <begin position="205"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM27005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="505" mass="58119" checksum="98E9274E8C7D86CF" modified="2014-04-16" version="1">MENPVDTPSKMSGRPRVDLEPYKAEIIGLFEKKMKGDDICKHLKRQHDIQISSRTLTKRLQLWGVKKKMENNSSNEALHARIKNLFFDVGLSDQEIVTVLHDEGYEVSHRTLRRLRHQLGIRLRLDSPAQQQAQVQEILDALTEEMDKGTIEGYGKELLHNHFRSKGHVFARDRLYSVYRMLRPDTVERRTSDVPRRPPPPKILAGPNLTWHVNGYSKLANFGFRIFAELDSYSRYVLWIHVGVDAHTAVGVLKNHLETVASKNRQPRTLRSDLESEVPLLADAHFALRRVTEPDVLREQCCAPGRATDTHRIESWWAQLAKSVVTLYHNYFRELHNEGLFSSTLIPEQVALFAIYMPTLRSHIKSYVQTWNIHNIRKQADHPERAPGKPYMNYHHPPKGVENFGLAADIATLQAMQQNHTDYDTEQYLPADTLHWCEAQLQQLGFDPRKPPARLPGDLQPFRSVYLALRERAWHHERSGAEPKLAVCTFPGQGLRGYFPSGSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W6PT75</accession>
    <name>W6PT75_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S01g001204</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PT75"/>
    <dbReference type="STRING" id="1365484.W6PT75"/>
    <dbReference type="OrthoDB" id="4366258at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM27393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="242" mass="28009" checksum="0327480CE1BCCC40" modified="2014-04-16" version="1">MVSALWIRLDEDEEVYGFIKSWYLWEESEDHPPGQIAPTPIENPDILEDVDYFLDIETRFMDFTDTITFLLSLTLLKIKILLDLKDLHQARQAVGPKVPQEVLDQILANIPRSSAIKANRRIMSSPDLSGEIARLDAQVDALYKKIHQTNFFWWRTLVDRPEDAIEAVVNRSHNGARPEFGSPLEAAIWITQRGQRFCWIETPGVLDFLREKNSENPLPRLSEVHRIYGRRADQLVVALYNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W6PTD3</accession>
    <name>W6PTD3_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Probable transposable element</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g001269</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PTD3"/>
    <dbReference type="STRING" id="1365484.W6PTD3"/>
    <dbReference type="OrthoDB" id="4763081at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM27458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="424" mass="46672" checksum="47E7FAEDDD8CBE50" modified="2014-04-16" version="1">MVEFKIRSRINYINKLDFLEVYPLLRIEAFKSETIKNSFLAAGLVPHVLKNPVSGIPDGSAFASRTETMLFLAPSTVKASKKSYLCRWAGCKTCAVGPDVVTVHADCLEVYLEHAASYEERKEPTKEKVGNEDKETGKGDDKNKKDTTDDKKINETENAALQRLWIASSWRTPWKKAPFLSLLQCDNARMSMPSPALLHRLGLPGMARMPPELASTVRDLSKDILLWRLNAAARLALSLAEYEKTETYGDDPAALPASILLSEVEAWERGRLLVRRVVSDEKKPELAEETIATDSFIRLAIDTYGLLHIKRLPARPAYNGTTSAAGRMLTTQLGLGRIELPAGLPGLQIWDTPAPPPIEGVAYMRKHLKRVSPTSYLHVVDLEAITGLTLLSDGNVLGLHAHTVAEPSATVTAARMALPTSRVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>W6PU98</accession>
    <name>W6PU98_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ferric-chelate reductase (NADPH)</fullName>
            <ecNumber evidence="3">1.16.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PROQFM164_S01g001140</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>2 a Fe(II)-siderophore + NADP(+) + H(+) = 2 a Fe(III)-siderophore + NADPH</text>
            <dbReference type="Rhea" id="RHEA:28795"/>
            <dbReference type="Rhea" id="RHEA-COMP:11342"/>
            <dbReference type="Rhea" id="RHEA-COMP:11344"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.16.1.9"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ferric reductase (FRE) family.</text>
    </comment>
    <dbReference type="EC" id="1.16.1.9" evidence="3"/>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PU98"/>
    <dbReference type="STRING" id="1365484.W6PU98"/>
    <dbReference type="OMA" id="RWAGYLC"/>
    <dbReference type="OrthoDB" id="167398at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052851">
        <property type="term" value="F:ferric-chelate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000061">
        <property type="entry name" value="Metalloreductase transmembrane component, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051410">
        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361:SF23">
        <property type="entry name" value="FERRIC-CHELATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="188"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="227"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="268"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="299"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="325"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="14">
        <location>
            <begin position="355"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CDM27331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="734" mass="83345" checksum="2D2F58BE92E234AE" modified="2014-04-16" version="1">MLSTIAKRINVAITASTTTAEAAEMQRDPWSKSAKYGVGFVYFAVVLLIITTFVRCWHKWGDKMRIALYKENRPEIFRDDSVPDEYELPSAGTDASNAQFFPSPTVVSPPKRHESILARIVPLNKAIALTRWIFYRPVPVLRVGNIELVLPSLAVTAIVLVAFVFVVLYCFVPQPLYYWSIALGSPPLAIRAGMLAVAMIPWIVALSTKANFITMMTGLGPERLNGLHRWSAYICLFLSLVHMVPFYITPIWEDGALVNYSIGIPPHAYVYGTGIAALVPLLVLCIHSLPVFRNWMYELFVFVHIPVSYIFVAMLFWHTRNYLSSWAYLFTTLAIWVISYLVRLFYLNWTHPLRSSFLIGEEAAITLLPQNAIKITIPTKMRWRPGQYVYLRLPRISVIQSHPFTIASLCSDDFPSAYGEKYRDMILVFRPFQGFTREVFQKALEHGPYKIYSAFVEGPYGGMQREMAAFDDVVFFAGGSGITAIASQLLDLIKKIRDGKAITKSVKVIWALKNPEMMEWFQEELRICRDYAPSNIVSCHFFLTGVKQDDQIGRDIVQEKIYGMLQGIDKRNSAYIRDEAAGNPDIEKELRRENEDGVAALPNAYMATHVPSTRQFYQPPMNLHSPAATNSGGTSNFDFRLGASQPVPPPVHAPRFAYYHARGRDNWRTDYFRPNITQMVNEFSKTFGRRACVFVCGPPSMRVEVANTVAKLQMQVIMDSSKDEIFLHAENYNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W6PUY3</accession>
    <name>W6PUY3_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g001854</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PUY3"/>
    <dbReference type="STRING" id="1365484.W6PUY3"/>
    <dbReference type="OMA" id="VQLCLPR"/>
    <dbReference type="OrthoDB" id="4363173at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM28043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="475" mass="54380" checksum="350A9588F45C80C2" modified="2014-04-16" version="1">MPPRATLPRAAKLDGKSAPKRVNAKRKKSLKEDEGAAPKKAKTETGIPQLLNEELLAADLKADYSKTWKKPRQEIPKKQKWPMVKDVITELEDTPKGWNPEEPDLMPDDFKAQIERCRERIAENIMPHVYRHKMKEFIAKQSQRERLMAREPGLSWPEAQRVDDLKFTLDQLAGENDEYKMVSTVKAIIARYRSGELSWNPDLVTYWYSGVQLCLPRPFHWDEYRYVHDKYEGHVGFWVEGILGPGPSMSKASMVCQPDPRLNATMVRVALRIPKVPAITVREGERKKEKGEKDPKPLSRPPFFDFPFMDDTGATHMLLFEDDINVLRNLEAESGPVYPLPRCMGVGVLYLADGNRVTSIFREIEVNMWSYDERKWMSPDWQAISACVQSGQSTRAGADRLLGSWLRHRFYTGTCPDQSLRLWVFDYNPGIPQGQRTLPTATPAQLNAPYPVARVRPIDDFPHLDPNLATGHGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W6PV36</accession>
    <name>W6PV36_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">25S rRNA adenine-N(1) methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PROQFM164_S01g001914</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the N(1) position of an adenine present in helix 65 in 25S rRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
            <location evidence="4">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the BMT2 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="4"/>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PV36"/>
    <dbReference type="STRING" id="1365484.W6PV36"/>
    <dbReference type="OMA" id="FHRTSKW"/>
    <dbReference type="OrthoDB" id="5954793at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016433">
        <property type="term" value="F:rRNA (adenine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03044">
        <property type="entry name" value="BMT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021867">
        <property type="entry name" value="Bmt2/SAMTOR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21008:SF1">
        <property type="entry name" value="25S RRNA (ADENINE(2142)-N(1))-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21008">
        <property type="entry name" value="S-ADENOSYLMETHIONINE SENSOR UPSTREAM OF MTORC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11968">
        <property type="entry name" value="Bmt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="4">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDM28103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="283" mass="31636" checksum="E036AD90A97F6DC0" modified="2014-04-16" version="1">MAPQKRSKRPLLLSHSRPRIVKSKDAALSAKATRTLIRSHHRLLKVRAQALAAGDEARVSSIDAQIQANGGLESYQIASKLGQSMDRGGDSSKVLIDWIKPQLKQWNKDIPKLRVLEVGALSTKNACSTNPALDVTRIDLNSQEPGILKQDFMERPLPSSDDERFDMISLSLVLNYVPDATGRGEMLKRCVKFLTSKCPIELVPSLFLVLPIACVDNSRYLNEGRLGEIMACLGFRLTQSKRTSKLVFHLWEHTGTYSPKAFKKEELRSGKTRNNFAVILNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W6PVP5</accession>
    <name>W6PVP5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S01g001786</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PVP5"/>
    <dbReference type="OMA" id="YHIDGRA"/>
    <dbReference type="OrthoDB" id="5100247at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM27975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="132" mass="15068" checksum="89801F8A2C56BC29" modified="2014-04-16" version="1">MESSLPEQLFLDLPVADVMNKTARIRMVEPWASRYCIAISEKRYGDAIYARYHIDGRAKDGIYTDLRDNGDRPYVLHETSVYDMIMEDAQGYAQGSPELYRDALLFYSKASLNDNRRDIIEGLFKLGSNGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2024-10-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>W6PW56</accession>
    <name>W6PW56_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S01g002279</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PW56"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM28468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="51" mass="5903" checksum="C0BBB4F17D7E74BE" modified="2014-04-16" version="1">MFNGVEGSWEVSLESRAPLHIGMLFTEHLSLFFRIDSLIFNEPYFSQSPKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W6PXB2</accession>
    <name>W6PXB2_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metallopeptidase, catalytic domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g002232</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PXB2"/>
    <dbReference type="STRING" id="1365484.W6PXB2"/>
    <dbReference type="OMA" id="WRIVARC"/>
    <dbReference type="OrthoDB" id="1046782at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057277">
        <property type="entry name" value="LysM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25139">
        <property type="entry name" value="LysM14_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Secreted LysM effector LysM C-terminal" evidence="1">
        <location>
            <begin position="454"/>
            <end position="575"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM28421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="577" mass="63694" checksum="E2314DF1F3871F48" modified="2014-04-16" version="1">MASNNIGSYSAYHLWLGRVKDSTKSSRINRYASYGFLGTVEWALDLTNFVLTAAEADATSNITAAEDAFTAALSLSGYNTSNFETYNLTLLASKLVGWHGCDPLQKKEIYSGWQQSWEIMNYMMSEAYDDKINWNEAATVEYLGAPAMNQHLRERFKNIYVNLATIQPGWIGMPWDWRIVARCDDPHLACSCGRDTQTVAYTVNSDQDEPSAPAINFCPPYFGQPTLKTVLESANPGFTPAIYADMNNYNGNQATTWMHELLHIDWVALANGWGPNTHVTDIKMKYNYDTGSKWVTAYAPYLNKGLARVQTQFADWTIQNADSMALFALAKFIQNKLGDIYPHLPLAPPPPLDVKRYLVPGYFDYYANGTGEILNQTAMDDASWTASMGTCALGTDPDGAAGSAAIATVTSWPVQTDYPDDYLSSWSSWAGLATSTTRKATSTTTAAPTPTESWSIAIYSEKDCSGDYYVVSGYNEDTTQNTCLVINDLTTTSSDTDVSCGWYTDGGFSNTSCDKGTLTKPLSWRITGPNGAICTAYNTNTCDNNGYEDAYTTWDECHNYSSSNFDTEEWIALQCGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2024-10-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>W6PXF3</accession>
    <name>W6PXF3_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S01g000448</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PXF3"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM26639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="62" mass="7401" checksum="7F228EE8302E9C2B" modified="2014-04-16" version="1">MAGHSFHVHRLRQTLLSRMRWLSTDKGGLKVARKHEQSHRLINRDQWLTTDRQGGTPLFQYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>W6PXH9</accession>
    <name>W6PXH9_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Calcium-transporting ATPase</fullName>
            <ecNumber evidence="18">7.2.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="primary">pmc1</name>
        <name evidence="23" type="ORF">PROQFM164_S01g002302</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Catalyzes the hydrolysis of ATP coupled with the transport of calcium.</text>
    </comment>
    <comment type="function">
        <text evidence="17">This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. Transports the calcium to the vacuole and participates in the control of the cytosolic free calcium.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16 18">
            <text>Ca(2+)(in) + ATP + H2O = Ca(2+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18105"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="18">Membrane</location>
            <topology evidence="18">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15 18">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.10" evidence="18"/>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1365484.W6PXH9"/>
    <dbReference type="OMA" id="YRMYVKG"/>
    <dbReference type="OrthoDB" id="3352408at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005388">
        <property type="term" value="F:P-type calcium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02081">
        <property type="entry name" value="P-type_ATPase_Ca_PMCA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000039">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000028">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000031">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000018">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006408">
        <property type="entry name" value="P-type_ATPase_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01517">
        <property type="entry name" value="ATPase-IIB_Ca"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093:SF369">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093">
        <property type="entry name" value="CATION TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08282">
        <property type="entry name" value="Hydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 18" id="KW-0106">Calcium</keyword>
    <keyword evidence="4 18" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="13 18" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 18" id="KW-0813">Transport</keyword>
    <keyword evidence="3" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="320"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="352"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="523"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="564"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1004"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1031"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1074"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1112"/>
            <end position="1129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1149"/>
            <end position="1171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1183"/>
            <end position="1203"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="22">
        <location>
            <begin position="290"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="20">
        <location>
            <begin position="389"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase C-terminal" evidence="21">
        <location>
            <begin position="1031"/>
            <end position="1203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="248"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1261"/>
            <end position="1326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1341"/>
            <end position="1437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="62"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="127"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="151"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="251"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="1299"/>
            <end position="1308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="1364"/>
            <end position="1384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="1388"/>
            <end position="1399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="19">
        <location>
            <begin position="1417"/>
            <end position="1428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00038148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00059328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU361146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF00689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF00690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="CDM28491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="1437" mass="156545" checksum="1F2C7F113A21E87D" modified="2014-04-16" version="1">MSDPRSKDEPGQSSTLRRERAPTITIDTSAVNPPDNEYTPLQIRSGGSRMYTDNAHAPDTTALLSNGSRNGSASSTDMHSTASIRSNASSEARDRESRPTSPHNISSPKTKAAETHSNFLSVPGTRSRGNSLESEETNQTSSTYGGDTYVPSSSQESASDSPKSPATNGVHDEDPLSPDPGREDEFEVEDNKFAFSPGQLNKLLNPKSFGAFHALGGLRGLEKGLRTDIKSGLSVDETNLDGTVSFDEVVTPTTPASGTNMPKSASPTKPPPPTTEGSVITQHNGENFVDRRRIYGDNRLPERKLKTIWELAWIAYNDKVLILLTIAAIVSLAVGIPQSLHPANPDEPGVEWVEGLAILVAIIIVVVVGAANDWQKEQQFAKLNKKKENRQVKVKRSGRTEEISVHDVLVGDVMFLEPGDMVPVDGILIDGYDLKCDESSATGESDVLRKTPGDEVYKTMEQNEDLKKMDPFIISGAKVSEGVGTFVVTATGTHATLGRTMMSLQEEGETTPLQTKLNKLAEYIAKLGLASGLLLFVVLFIKFLVRLKDIAGGPDAKGQAFLQIFIVAVTIVVVAVPEGLPLAVTLALAFATTRMLKDNNLVRYLKACETMGNATTICSDKTGTLTENKMTAVAATLGTTSRFGKYSGVSSDDQSEITPSDFVSSLSPSVKDVLLKSIVYNSTAFEGETDGVKTYVGSKTETALLTFARDYLGLGPLGEARANGKVVQMFPFDSGRKCMAVVTQLENGKYRMLVKGAAEILSHKSTRIVQDPTDTLSETPVTDENRTALDSIMTTYATRSLRCIALVYRDFDQWPPRGAPTSETDDTQAVFEPIFKDMAMLGIFGIQDPVRAGVAEAVYTCQRAGVFVRMVTGDNIMTAKAIAQECGIYTPGGIAIEGPKFRKLSTRQMNQIIPRLQVIARSSPEDKKILVNQLKKLGETVAVTGDGTNDAPALKNADVGFAMGITGTEVAKEASDIILMDDNFSSIVKAMAWGRTVCDAVKKFLQFQITVNITAVILTFVSAVASDNEDSVLSAVQLLWVNLIMDTFAALALATDPPTETVLDRRPESKSDPLITLTMWKMIIGQSIYQLVVTFVLNFAGDKIFSWDSGHLQTVVFNTFVFMQIFNQYNSRRIDNKLNILEGILRNRWFIGIQIIIIGGQILIIFFGGAAFSVKRLNEGSQWAVSLVLGAISIPIAVIIRLIPDEFISRLIPHFWNRNKGPALVISDEDRNYEWNPALEEIRDQLAFLKRVRGGRLRHLRHKLQHPQEFLPRSRSGSRSRDSSTPPTPNGDNDHENDNGSPQPTTPESRSRRNTRSRSNSTFGPAAAMAGIVAGSIAGWSPIERGHDEPEQVTFPTNGGPHSGLDREPGIEIHPDTAADDRILNEYSPDSKTPPSQNPDLIPFFEHAPPDRAPSSRGRRSLSQRSRSRSSLSQSHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W6PY91</accession>
    <name>W6PY91_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AMP-dependent synthetase/ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S01g002532</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PY91"/>
    <dbReference type="STRING" id="1365484.W6PY91"/>
    <dbReference type="OMA" id="WLLERWE"/>
    <dbReference type="OrthoDB" id="6614653at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031956">
        <property type="term" value="F:medium-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201">
        <property type="entry name" value="ACYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201:SF8">
        <property type="entry name" value="ACYL-COA SYNTHETASE FAMILY MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="2">
        <location>
            <begin position="76"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="3">
        <location>
            <begin position="441"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM28721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="572" mass="63854" checksum="0D2B075D434F1CDA" modified="2014-04-16" version="1">MDTPEPSVLLLPDDPFFHELFNRHTQDPEACVIYDRASERSVTPYHFLVDILQTVDRVRRILSQGEETPSANNIFVCVLVPYGYEYAVTILALRALGLTAVPVSEAILPEEFEYFVQVCNATYLITIPSLQDHAESLLSGTSLAILTLQLPLSITQPLPVLRKPLQVSETWNTDRGAILLFTSGTSGPPKGVLHTHRSVYIGAKEWIETYGLTRDDRILLPWNSHWCAGFMMLSGCILAGTCAEICSTVFNPAWFWERIKAAEVTFLHLTPSLLGPAIEWYAREVIRQSPQEVEGYLVGSRRLRTVVIGSTTVPTPVADFWIEKGVKFDLHYGCTECWMIAATDWRKSKGFTPRHVGKLVSGVETTLASESEGEMAIKSQGLFQKYLSANPHIMNNVFDDNGYYLTGDFIRRGHDASLFILGRASQDVVRFSGWKVFTLDVEDALLNIPHIAAAVVLGVDDDTVGQRVSALIVTKPQLEQSLPQKVSLATLRRTLALEQQLPVYKLPTLMRFLAPGEEIPRTNSGKVSKASARKKFFASDDLDSEKVEAWDLNRKDEDLPTRAWDWAGIGAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W6PY93</accession>
    <name>W6PY93_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative cytochrome b5 B11H24.095</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PROQFM164_S01g000753</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the cytochrome b5 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PY93"/>
    <dbReference type="STRING" id="1365484.W6PY93"/>
    <dbReference type="OMA" id="FWKYHGD"/>
    <dbReference type="OrthoDB" id="260519at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000007">
        <property type="entry name" value="Sulfite oxidase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050668">
        <property type="entry name" value="Cytochrome_b5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19359">
        <property type="entry name" value="CYTOCHROME B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19359:SF14">
        <property type="entry name" value="CYTOCHROME B5 A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0349">Heme</keyword>
    <keyword evidence="3 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="6">
        <location>
            <begin position="2"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM26944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="84" mass="9364" checksum="43F11E18F63D758C" modified="2014-04-16" version="1">MSKTFTPAEVANHKTADKGLYIIIDSNVFDVTNFVDEHPGGAKILKRVAGKDASKQFWKYHNESVLKKYSPKLKVGEVKDAAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W6PZI9</accession>
    <name>W6PZI9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Gurmarin/antifungal peptide</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PROQFM164_S01g001163</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PZI9"/>
    <dbReference type="SMR" id="W6PZI9"/>
    <dbReference type="OMA" id="MGICESG"/>
    <dbReference type="OrthoDB" id="4233515at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009101">
        <property type="entry name" value="Gurmarin/antifun_pep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024206">
        <property type="entry name" value="Gurmarin/antimicrobial_peptd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11410">
        <property type="entry name" value="Antifungal_pept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57048">
        <property type="entry name" value="Gurmarin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0929">Antimicrobial</keyword>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0960">Knottin</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004879818" evidence="4">
        <location>
            <begin position="18"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDM27354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="57" mass="5796" checksum="7F7607BB9634B78D" modified="2014-04-16" version="1">MRLTFIVFMAIIGAALAADKAPPTIQNGSPCKADGSAGICASGFCLQLAHDNEGVCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W6PZJ4</accession>
    <name>W6PZJ4_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">6-methylsalicylate decarboxylase</fullName>
            <ecNumber evidence="7">4.1.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PROQFM164_S01g002958</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>6-methylsalicylate + H(+) = 3-methylphenol + CO2</text>
            <dbReference type="Rhea" id="RHEA:23112"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17231"/>
            <dbReference type="ChEBI" id="CHEBI:36658"/>
            <dbReference type="EC" id="4.1.1.52"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:23113"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily. ACMSD family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.52" evidence="7"/>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PZJ4"/>
    <dbReference type="STRING" id="1365484.W6PZJ4"/>
    <dbReference type="OMA" id="IILSHMG"/>
    <dbReference type="OrthoDB" id="2832284at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047596">
        <property type="term" value="F:6-methylsalicylate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032465">
        <property type="entry name" value="ACMSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240">
        <property type="entry name" value="2-AMINO-3-CARBOXYLMUCONATE-6-SEMIALDEHYDE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240:SF29">
        <property type="entry name" value="AMIDOHYDROLASE-RELATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="9">
        <location>
            <begin position="4"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00036832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDM29146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="340" mass="37344" checksum="372F87DD4B195FB0" modified="2014-04-16" version="1">MNRIDVHHHFIPPAYVNAFNSTSGDPSGWHLPKWTPESTLSLMTSHSTRAAILSLTAPGTSILSDSPMDSAALARQVNLYGCQLHRENPTRFGFFASLPHLTPETIPSAIEEVAYALDTLQADGITLYTRYSGTGYLGHAAFAPLWEELNRRKAVVFIHPTNITSDAQDQPQMGIAKLPQPIIDYPHETCRTAVDLITSGAISKNPDVKIILSHGGGTLPVLATRAANLLYDAGLTEITPEIFMEQARGFYLDLALSGNEGNLELLLGKTGFAKPGHVLYGSDFPYAPVNTINKYVGMMEGFFAREEEKEEEIARGAAVELFPRFRIEEDREEVLTNPGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>W6PZK2</accession>
    <name>W6PZK2_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">galacturonan 1,4-alpha-galacturonidase</fullName>
            <ecNumber evidence="12">3.2.1.67</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Galacturan 1,4-alpha-galacturonidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Poly(1,4-alpha-D-galacturonide)galacturonohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">PROQFM164_S01g001185</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Specific in hydrolyzing the terminal glycosidic bond of polygalacturonic acid and oligogalacturonates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>[(1-&gt;4)-alpha-D-galacturonosyl](n) + H2O = alpha-D-galacturonate + [(1-&gt;4)-alpha-D-galacturonosyl](n-1)</text>
            <dbReference type="Rhea" id="RHEA:14117"/>
            <dbReference type="Rhea" id="RHEA-COMP:14570"/>
            <dbReference type="Rhea" id="RHEA-COMP:14572"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58658"/>
            <dbReference type="ChEBI" id="CHEBI:140523"/>
            <dbReference type="EC" id="3.2.1.67"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 17">Belongs to the glycosyl hydrolase 28 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.67" evidence="12"/>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PZK2"/>
    <dbReference type="STRING" id="1365484.W6PZK2"/>
    <dbReference type="OMA" id="YSPQWYT"/>
    <dbReference type="OrthoDB" id="187139at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047911">
        <property type="term" value="F:galacturan 1,4-alpha-galacturonidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000027">
        <property type="entry name" value="Probable exopolygalacturonase X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000743">
        <property type="entry name" value="Glyco_hydro_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31736">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31736:SF14">
        <property type="entry name" value="EXOPOLYGALACTURONASE X-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00295">
        <property type="entry name" value="Glyco_hydro_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00502">
        <property type="entry name" value="POLYGALACTURONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
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    <keyword evidence="9 17" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 17 19" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 18" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004879279" description="galacturonan 1,4-alpha-galacturonidase" evidence="18">
        <location>
            <begin position="24"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="active site" evidence="16">
        <location>
            <position position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00041604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00043142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU361169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CDM27374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="435" mass="47077" checksum="FD92696AE814EFED" modified="2014-04-16" version="1">MKISSTFNQALGFCLLISAAVQAKGYSRSEACQPHHPFKPLPGSQARTRTCHVVNHGHGRDDSANVLTALKKCNNGGKVVFDADKTYTIGKALDMTFLKHVDLEIQGHIQFSNDTDYWQANAFKQVYQNATTFFQLGGEDVNVYGEGTLDGNGQVWYDLYAEDALILRPILVGIIGLNGGTIGPLNLRYSPQWYHFVANSSNVLFDGIDITGFSSSANVAKNTDGWDLYRSTNIVIQNSVINNGDDCVSFKPNVTDILVQNLHCNGSHGISVGSLGQYPGEIDIVQNVLVYNISMFNASDGARIKVWPGTPSALSTDLQGGGGSGLVKNITYDSMTIDNVDYAIEVTQCYGQKNLTLCNEFPSKLVIEDVFFKNFNGVTSGKYDPYVGTIVCSSPDVCSNINASGIDVVSPDGNDQFTCTNVDDNLLDLNCASSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q090</accession>
    <name>W6Q090_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S02g000082</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM29933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q090"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM29933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="78" mass="8895" checksum="9270ED943E29B3E6" modified="2014-04-16" version="1">MTNLVRTTRNAQATASIARKGLRVFATAASLRFSPTHRLFLRKHILGCIQPSIVPGELRKPRRVPHQDQSRPDQKPWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q129</accession>
    <name>W6Q129_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S02g000387</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q129"/>
    <dbReference type="STRING" id="1365484.W6Q129"/>
    <dbReference type="OrthoDB" id="4368535at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="234"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM30238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="245" mass="27961" checksum="D3B6A65FEE312EC0" modified="2014-04-16" version="1">MHSNSGKCRLEFAHEWATNDVWNHGCNYLDQKLSSEGDMSNVNEDVMSESASETLVKSEGDTSGNGSFTGQTSQDELTEDKLPRKKKSSVNKVSTQLVLAIYVRETTASNASEDEIETAKHTGLKSKSRRRKIEKPEKEQKEHKKQMKQKKAESKQYEEEKSTPARKMGTREEEPEERQFEEHESKEKAEEMKLAKKQKKHRKLEAKLREESCRKDSAALSSRKRKADNEDEVTTTSTTATEETA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q1J4</accession>
    <name>W6Q1J4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S02g000562</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q1J4"/>
    <dbReference type="STRING" id="1365484.W6Q1J4"/>
    <dbReference type="OMA" id="DQKWQCE"/>
    <dbReference type="OrthoDB" id="5395440at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056023">
        <property type="entry name" value="DUF7603"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24554">
        <property type="entry name" value="DUF7603"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7603" evidence="3">
        <location>
            <begin position="682"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="220"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="335"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="503"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="293"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="419"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="578"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="756"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="845"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="224"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="337"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="525"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM30413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="915" mass="102126" checksum="5AE68B1C9D785783" modified="2014-04-16" version="1">MASPLEFGGSPAHSESFSSPNPPPTTPPVRTKPLPHNDGPVTSGPDHPSSPISFEGDKPISIPTAPLSPLSVDGDSYISVPKNSNRYSRGRNDSQPLYIDTAASRHGSASYLRSVLEDDDDDDDDEDEGSNYFDEEYEHQFMNGTPLHSRLDSEPFIPILRSPPLTKRSSRRATSMALHMSMNRPPPLHFKVDSRAVSMSMGAGDPRNPRTPGNKISSFFGWKGNNTSPGGESSSTEISDSGRSATHFPMPPLANVPFNPGSPYDPKTNGYGHPARTSMGSSSLKENIFISKIADIENELREISSELARSIRREMDLEDLVERLQLEGPDINRRTSDYFSDSGNSSVRYASDAGKSEDIEKIRRAADQERAQLKVELSQKLQEERSQRLASESHVQILESQVQQLRRDRTDTSDLSSKTKELETALENTKRKLLEERQSKDNFEDLLTAMRVELEQLRNDRDQLRDDNRLIEEIEALKIENASLAQLQGGRFASIAEEGASPRNSAFGVRRSSSVARKPSSLAHSGGLSRSNSVNNNSGGKSPETRESLVDKVHDIEVQRDVLHRTLRSLLDRQAYQAREYEKRTRLLEMELARAQQSGQPRKLGYERDVRNLRDEVNHLRMRAEDALDGKWQCEKNLAGLKMDLDRAEQETSSLRALLVEDTAAGAELMTGQEGFAEVATTSSSLQSAFQKLQADQAEAKAGVADSEELASSLIRIETLGSKVHYQLQTNTSLHSRLATAIDKGDKDQQLSVERINILQNHMRELEEVLLVAQNHTEEEMGKHEDELRLLKESQHAQLTRMMNGGRNTLVLSPRPPNAPFDARSPRLDQTTSGEGVPLTQVVQSEILERRVKDLEKLLRDADMEMEQVVGRMNRTQIDVAQLQTDRDDALRQTRQLLAEIQAERDALRGLIDAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q1L1</accession>
    <name>W6Q1L1_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC transporter, ABCB2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PROQFM164_S01g003659</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM164</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
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    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="190"/>
            <end position="210"/>
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        <location>
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        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
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    <name>W6Q1L8_PENRF</name>
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        <submittedName>
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        </submittedName>
    </protein>
    <gene>
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    </gene>
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        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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    <dbReference type="STRING" id="1365484.W6Q1L8"/>
    <dbReference type="OMA" id="PRMSKRF"/>
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    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
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        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF40">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
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    </dbReference>
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        <property type="entry name" value="Zn_clus"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
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        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
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    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
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        </location>
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            <end position="76"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
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        </source>
    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CDM30433.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="662" mass="74551" checksum="F21EF737B47DE586" modified="2014-04-16" version="1">MASRLAACEACRKAKVACDHKRPACTRCASNDRAGICIYRTTPFKRRRAESSTPLQSPSRLPPAQPSFTPRNNPYPNPGFLGSSSHVAIFNEISPQDYHASDTYQASEDLTMLMQLQSTGENILLIQGADVLRQLFNTFPLAAMKDFVTFWLATGANLALAEPFTEKCTENMTRLFTSFSQEDNWHLAYAQRLTQNSREPLQFDSTSDMESFSAQFLDQKFRWESLGIFLSAVSRAAIAIPFFPPLFKTEKDNFVLRKLSTRLSDLALDIVLSLDCLNDLQLVLQYENFIVHTHVDGDQSYHSWSRLGGVLSSMFALGYHENIEKTKPPIPTFLSELRKAAWATTYSADKNVAIFLGRPPRMSKRFCHFQLPLAPTSSDQVFNASPVEDEVVRWKIDTPICYRAGIRWATLCSGLKEDVLELLRLKQRENFNRKASVIRQKAETQWANLPSQFRLSGPLKECSGDAFERDLIASIRLDQLHVLFLLQLSCLDTLTEPDPCILDISDQILSLVVDTILLRDQLVNSGIGLIWKIAHFGLPATGIILLSMLKEHRTLTEGRSSWSKTILNLGIFVAQVQVGSIVRRGDPNYALISKATQTIERFLDSIQREGIQSPTQLSPQPGENGDWAAFFSQDLCDFETDFWENLAYHPSLLPSDPILPPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q1V7</accession>
    <name>W6Q1V7_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosome control protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PROQFM164_S02g000404</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1365484.W6Q1V7"/>
    <dbReference type="OMA" id="MVYDRAM"/>
    <dbReference type="OrthoDB" id="67540at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034066">
        <property type="term" value="C:Ric1-Rgp1 guanyl-nucleotide exchange factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040096">
        <property type="entry name" value="Ric1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009771">
        <property type="entry name" value="RIC1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22746:SF10">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR SUBUNIT RIC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22746">
        <property type="entry name" value="RAB6A-GEF COMPLEX PARTNER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25440">
        <property type="entry name" value="Beta-prop_RIC1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07064">
        <property type="entry name" value="RIC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101898">
        <property type="entry name" value="NHL repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69322">
        <property type="entry name" value="Tricorn protease domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RIC1 C-terminal alpha solenoid region" evidence="4">
        <location>
            <begin position="828"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="29"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1051"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1051"/>
            <end position="1068"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDM30255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="1078" mass="119176" checksum="B7B9DB3829369050" modified="2014-04-16" version="1">MYWPHGVPRVYAVNGPDIAYTSSDEDRELLNTSSTNDGNAFDDGAEIRESDGQHESAETQPHESQTKSSLDTGKSEWGDEAIRGICVSRSGQMFATMSESSIALWQTRPTAVVTAISRSQFSLKTYGPNVSLLMHPNSTILVVQTLNGYLLTYSVTSDSTTQVYQQRFDHSTNPRRQQLARFSAVEEANVVGDINIRFRMAIKIESGIVKALALDQELVVATVKPPAIQCIRWTPEAGGAQTTSELLSRIPGISKKVSIVDMVYDRAMNLLIWITSSGQTYAVQRDSGSQQDPEAAKKLFHGHCFHDPKDDSEKAVKVTVNARFSLLTVSCSNGDILVYTAKDYMGNIPLSQKLHLPASPTTTGALTFMSYSPDGYCLFAGFENGWTTWSVFGKPGGNSFSVDTTLATANSEDWLTGVSDGCWIGGGSDIILSGQNDRRLWVLETARSALTGCFSSANLARGLLQTGTEFILYRGHDLPDLMTISGKDSLWHHGQYPPAYLHSQWPIRSCVVSQDGRYVAIAGRRGLAHYSVNSGRWKVFEDSKAESSFAVRGGMCWYGHILIAAVESDGSYEIRLYSREASLGNNSIMFIEYLPSPVVFIGTSGEDSLLVYTYDNILYHYIINSTQPQITLVPVGQIAFHGIVRAPSRVRSISWVLPEEQMRNGDPSQDVKVASVLLLVDGNLVLLQPTVSDAGDLKYDMRVISHDVEYYILMRDQISFNFSLQVDESLPASPSVDIALEPPHSSLSLRDSLWMFRGQNLLAWNDVQDVLREEMVPAPLDIPLDFYPLSVLLNKGIVLGVESEMMQRRDVTFTVLKFAIRTHLFLPYFLQYGLASVGTPAALALCRHFSHLSYFAHGLEILLHHVLDDEVDNESRANKSDNPQARAEPLLPTVIAFLQASLPARDYLEIVVQCTRKTELRSWRTLFTYLPPPKDLFEQALKLDSLKTAVGYLLVLQAFEDEEHGHDGRIEEYVVRLIALASHKGDWELCAELARFLIALDASGEMLRRAISRVGLRPNSQPSAKGTFPNSAPRFGPAGVQGLGLNLPMRSPSWASLSPTSSLSPLPSRQDGDVLDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q2M0</accession>
    <name>W6Q2M0_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="8">NAD(P)-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PROQFM164_S01g002270</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FMP52 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q2M0"/>
    <dbReference type="STRING" id="1365484.W6Q2M0"/>
    <dbReference type="OMA" id="CIENAKA"/>
    <dbReference type="OrthoDB" id="430436at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051170">
        <property type="term" value="P:import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000366">
        <property type="entry name" value="Protein FMP52, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14097">
        <property type="entry name" value="OXIDOREDUCTASE HTATIP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14097:SF7">
        <property type="entry name" value="OXIDOREDUCTASE HTATIP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="7">
        <location>
            <begin position="5"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM28459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="229" mass="24817" checksum="A7F3A0544D452153" modified="2014-04-16" version="1">MATAAVFGCTGAVGSQILATLLSSDAFSKVKTISRRLPNAQADKLEALEESDTSKWGDMISSLSPKPSVVFNAVGTTKATAGSIQNQWKIDHDLCVENARAAKEAGVKTYVFISSGGTRSLLWGWVPYSKMKVGVEDAIMEFNFENAIVLRPGMIIGREKSKSFLLEKFVEGLQKLGQGIQDKVGQDQTTIGRAAVAAARLVEEGKAPSSYWTLEQADIVRLGRDEWKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q2R1</accession>
    <name>W6Q2R1_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major facilitator superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PROQFM164_S02g000988</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q2R1"/>
    <dbReference type="STRING" id="1365484.W6Q2R1"/>
    <dbReference type="OMA" id="TSNRWAW"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000064">
        <property type="entry name" value="MFS allantoate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF40">
        <property type="entry name" value="THIAMINE PATHWAY TRANSPORTER THI73"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="140"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="175"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="277"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="313"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="341"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="367"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="401"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="435"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="49"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM30838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="492" mass="54119" checksum="2B0F764FEE8BCAF2" modified="2014-04-16" version="1">MGEIQPEVVAHPSADEIDDAVVYLKGHEKEALDSPVNLRALRRKIDRRLIPYMFCCYVLQFLDKVMLNYAAVMGIKKDLGLVGNDFSNVATWFFIAYLIAEVPNVYFLQKVPPAKWLGGNVFLWGVAAAASSGARGYRSLLAARIFLGIFEATVGPSLMLISSQYYTRSEQAPRFTVWYMGLGVAQIIGGIISFGFQHVHHALLDSWRIMFLVLGLVTTVVGGLTFFFIPDTPMKATWLSDNEKVALLQHVSENQTGVWSANLNLKQIREAVLDIQLWLLTVTTILISVSSGVVTTYSSTLIAGFGFSGPISALLNTPSGIVSIFFTLLVGFGIRRTSNRWAWNILCTIPGIIGGGLLSFLPKSNKAGVLIGIYLVNAIVATLPILYQWTMANCAGHTKRAFASALVAGSFSVGNIIGPQTFQSHDAPEYRPAKIAVLATQAAAALLSVVLFFYYKWQNHRRDQTKSGVDAADQTRWAGLTDKQNHSFRYVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q3C6</accession>
    <name>W6Q3C6_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S02g001253</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q3C6"/>
    <dbReference type="OMA" id="QIFRCLK"/>
    <dbReference type="OrthoDB" id="4154127at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM31103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="129" mass="14818" checksum="5BD2D12B2D3FB28A" modified="2014-04-16" version="1">MECFRQIFRCLKAPFKRDKGRIIEIGPPTNFRKEELPAYFSDAESDAYVRGQPHSDRGEGRNNDRDAIATIVDEEQDAGPCSKNERETIRERVKLSRWWKSSPASDHKTKAPAESIKMEEMRNADLACS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q3U1</accession>
    <name>W6Q3U1_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosome assembly factor mrt4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PROQFM164_S02g001170</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 6">Associates with the pre-60S ribosomal particle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
            <location evidence="6">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the universal ribosomal protein uL10 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q3U1"/>
    <dbReference type="STRING" id="1365484.W6Q3U1"/>
    <dbReference type="OMA" id="LEWAENY"/>
    <dbReference type="OrthoDB" id="10262308at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05796">
        <property type="entry name" value="Ribosomal_P0_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1730:FF:000005">
        <property type="entry name" value="Ribosome assembly factor mrt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.105.20:FF:000003">
        <property type="entry name" value="Ribosome assembly factor mrt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.105.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033867">
        <property type="entry name" value="Mrt4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001790">
        <property type="entry name" value="Ribosomal_uL10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040637">
        <property type="entry name" value="Ribosomal_uL10-like_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043164">
        <property type="entry name" value="Ribosomal_uL10-like_insert_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043141">
        <property type="entry name" value="Ribosomal_uL10-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051742">
        <property type="entry name" value="Ribosome_Assembly_uL10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45841:SF1">
        <property type="entry name" value="MRNA TURNOVER PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45841">
        <property type="entry name" value="MRNA TURNOVER PROTEIN 4 MRTO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00466">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17777">
        <property type="entry name" value="RL10P_insert"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160369">
        <property type="entry name" value="Ribosomal protein L10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL10-like insertion" evidence="7">
        <location>
            <begin position="126"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM31020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="246" mass="27703" checksum="9BAD6F4327A866DF" modified="2014-04-16" version="1">MPRSKRARIVHESKTAKKDHKEQTRRLFANIRECIEEYDHLFVFAVDNMRNTYLKDVRTEFADSRVFFGKTKVMGKALGADVESEAAPNLRKLTPFLAGAVGLLFTSRTPESVIDYFENFRPQDFARAGTEATRSFTIPNGLVTARAGEIPAEQDEPVSHTIEPALRKLGVPTRLVKGKVMLELTEGQEGYPVCKEGETLDSRQTTLMKMFGITSSEFKVDLKAYWTRSTEEVKILETEGGMDVDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q4P4</accession>
    <name>W6Q4P4_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pre-mRNA-splicing factor 18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PROQFM164_S02g001763</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PRP18 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q4P4"/>
    <dbReference type="STRING" id="1365484.W6Q4P4"/>
    <dbReference type="OMA" id="SFAQVRW"/>
    <dbReference type="OrthoDB" id="10261918at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071021">
        <property type="term" value="C:U2-type post-spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000350">
        <property type="term" value="P:generation of catalytic spliceosome for second transesterification step"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.940.10:FF:000008">
        <property type="entry name" value="Related to potassium channel regulatory factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.940.10">
        <property type="entry name" value="Functional domain of the splicing factor Prp18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004098">
        <property type="entry name" value="Prp18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014906">
        <property type="entry name" value="PRP4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036285">
        <property type="entry name" value="PRP4-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039979">
        <property type="entry name" value="PRPF18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13007">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13007:SF19">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02840">
        <property type="entry name" value="Prp18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08799">
        <property type="entry name" value="PRP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00500">
        <property type="entry name" value="SFM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47938">
        <property type="entry name" value="Functional domain of the splicing factor Prp18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158230">
        <property type="entry name" value="PRP4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Pre-mRNA processing factor 4 (PRP4)-like" evidence="9">
        <location>
            <begin position="133"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="57"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="10"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="57"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDM31613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="366" mass="42487" checksum="3900BE868156BEAF" modified="2014-04-16" version="1">MDFAALMSKEISKAKGSDSSKPSAKDTAKSSPVPAKKYMRRGDVEAARIQAYKEEQERLAREREERMANKRKLEDEEADRNREREEKKRRLAEESKTRREQEESAKERERRRRLGLPELPENTPADGDEEEDIEEEELIAKLRELNAPIILFGEDYRARLRRYRRLVQRAAIPKKKVTDGPIPTTLEPVPGGQMIIPAKIPKDQEGRLFLFRQLGSYFNMVLSEWELALAKRDVSVRESFQGKQAFNAMTQSRENMTPLFRLFEKAELEDGLLEPIVEIVHKAQQRRYVDANDAYLRVSIGKAAWPIGVTMVGIHERSAREKLHQSDQQAHILSDEITRKYLQSIKRCLSFAQVRWPPEDQLQMMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q4X5</accession>
    <name>W6Q4X5_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">cyclin-dependent kinase</fullName>
            <ecNumber evidence="2">2.7.11.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PROQFM164_S02g001176</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="2"/>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q4X5"/>
    <dbReference type="STRING" id="1365484.W6Q4X5"/>
    <dbReference type="OMA" id="GFCHSCN"/>
    <dbReference type="OrthoDB" id="1732493at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000524">
        <property type="entry name" value="Cell division protein kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF46">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="1"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDM31026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="289" mass="32916" checksum="5837B95A60662400" modified="2014-04-16" version="1">MQRLVYKGRNNQTNELVALKEIHLDADEGTPSTAIREISLMKELHHENILALYDVVHTGENLVIVSEYMDKDLKRFMDDRGGALDLPTLKFFAYQMLRGIAYCHENSILHRDLKPQNLLISRDGDLKLADFGLARAFNIPINTFSNEVVTLWYRPPDVLLGSRSYDTSLDLWSAGCIIAEMYTGRPLFSGNANNDQLLKIFQVMGTPSERTWPGISQLPEFKPNFPIYLSQDLRLLIPRMDPLGADLLERMLQLQPELRISAADALRHSWFDNLVSETGLSTRNVPMIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q4Z5</accession>
    <name>W6Q4Z5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Snf7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S02g001201</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q4Z5"/>
    <dbReference type="STRING" id="1365484.W6Q4Z5"/>
    <dbReference type="OMA" id="KILWEVT"/>
    <dbReference type="OrthoDB" id="2329734at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10476">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM31051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="232" mass="25943" checksum="60DAF204ADE6AE55" modified="2014-04-16" version="1">MESLKAVFFGPDPQAQMRKCNALIRTNTRQLDRDLARLKASDSQTRQYIVNASKRAQRNPSQAKQANNDTKVFARELVRIRKQTTRLNTSRAQLQSVGMQVNEAFSARKIQGSLQKSTGIMKDVNTLVRLPQLSATMHQLSSELVRAGIIEEMVDDATMDPSVFEDEEGEAESEIEKILQEVLQGKLAQAQPVTTTPVAKISEPESPQAEEEFEDQEATLAQMRGRLEALKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q5M5</accession>
    <name>W6Q5M5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ankyrin repeat-containing domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g003346</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q5M5"/>
    <dbReference type="STRING" id="1365484.W6Q5M5"/>
    <dbReference type="OrthoDB" id="539213at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="13"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="125"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM29534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="238" mass="26412" checksum="C592ECEBD29D8FE4" modified="2014-04-16" version="1">MRSGVDPNIYSLTGGFMLHVAVAANQPRMVTLLLEYGADPSYVHFKYRNAPYDDFMCWTDLALLRAFSGGAKVAGFAYYIQLVGLAGKSCRDTVAHALAGRNDCQFFPKVAPHLTNETITKISIRGETPLHAARKQTAPDIAREFIEADADPKSLDKSIDATLLTGFQNRHFELARLMRNSNAELAPGKYIGGREILVAISAWEVDIVRMLIRRSVRNILRRLCAPFGWKLGGREVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q5S9</accession>
    <name>W6Q5S9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S02g002199</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q5S9"/>
    <dbReference type="OrthoDB" id="3940621at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM32048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="262" mass="30524" checksum="B60ABBA2FD99FECC" modified="2014-04-16" version="1">MNQDCSREESKPPLFARLGEFSKLPPELRFQIWNCLFDDFLWNTSSTPCGLSIISCNRYLNEETTRILYERRVLSLTIVIRCSPEGGRIPEFHAIVKAAKGAGKLMGVKFMGLSYLDDVLRLVRNFPSWRFQKCGPWIHVNYFCLLCPSEELELWDCVVRVVDTLKLIPNGKNITFNTFYPYPLLREQTVGLTRSGVIKDWFDERFPGQPVPFRSRHRPDIRDHGYPPGPCLIIPVYHYTVLQAMRSAELKRHERDKLEVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q6Q7</accession>
    <name>W6Q6Q7_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cys-Gly metallodipeptidase DUG1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">DUG1</name>
        <name evidence="11" type="ORF">PROQFM164_S02g002539</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM164</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="8">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20A family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q6Q7"/>
    <dbReference type="STRING" id="1365484.W6Q6Q7"/>
    <dbReference type="MEROPS" id="M20.017"/>
    <dbReference type="OMA" id="CNVKFMI"/>
    <dbReference type="OrthoDB" id="7832001at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070573">
        <property type="term" value="F:metallodipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05676">
        <property type="entry name" value="M20_dipept_like_CNDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017153">
        <property type="entry name" value="CNDP/DUG1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051458">
        <property type="entry name" value="Cyt/Met_Dipeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43270">
        <property type="entry name" value="BETA-ALA-HIS DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43270:SF4">
        <property type="entry name" value="CARNOSINE DIPEPTIDASE 2, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037242">
        <property type="entry name" value="CNDP_dipeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="10">
        <location>
            <begin position="216"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="100"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="166"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="7">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between homodimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between homodimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="330"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between homodimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="7">
        <location>
            <position position="343"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between homodimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="7">
        <location>
            <position position="417"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between homodimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="445"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="7">
        <location>
            <position position="445"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between homodimeric partners</note>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="9">
        <location>
            <position position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR037242-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR037242-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR037242-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR037242-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDM32388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="477" mass="52870" checksum="B17742FD309BEBB2" modified="2014-04-16" version="1">MAPQLEPFFKQVDASSNDFIDRLRKAVAIPSISAQDENRPDVFRMGQFLADELTALGAEVEQRPLGKQPGKEHLELPPVVVARYGNDKNKRTILVYGHYDVQPALKEDGWATEPFELTIDEKDRMYGRGSTDDKGPVLGWLNVIDAHRKAGIEFPVNLLCCFEGMEEYGSEGLDDFIKDESKKYFKDTDAVCISDNYWLGTEKPCLTYGLRGCNYYSISISGPAQDLHSGVFGGSAHEPMTDLVNVLSKLVDAQGNILIPGIMDLVAPLTEEEKTLYGKISYTMDNLHESLGAETGIHPTKERTLMARWRYPSLSIHGIEGAYSAPGAKTVIPAKVIGKFSIRTVPNMESEDVTKLVIDYVKAEFAKLNTKNTLDVWLQHDGKWWVASPKHWNFSAASKAVQQVFGVEPDMTREGGSIPVTLTFEQATGKNVLLLPMGSSTDAAHSVNEKLDKRNYIEGTKLLGAYLHYVAEEPTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q719</accession>
    <name>W6Q719_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S02g002311</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q719"/>
    <dbReference type="STRING" id="1365484.W6Q719"/>
    <dbReference type="OrthoDB" id="3945418at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM32160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="176" mass="20235" checksum="8E4FF86DC3BA48CB" modified="2014-04-16" version="1">MFYFLLGSAVAYNLVMVIYRLHFHKLSRFPGPRLAAASGLYEIYFSVWGPGIFDHEIDLMHRKFGPVVRITPDEIHIQEPSSYSDGWIKGTEEVEPGYQGRSVHSFQYKRPSIARVRSLLWAKVNDMINPLIEKHHVDRMLSARPRLFLICPWSKKKVQSIGESESEDGGARSLQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q798</accession>
    <name>W6Q798_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Chromatin modification-related protein EAF6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PROQFM164_S02g002386</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the EAF6 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q798"/>
    <dbReference type="STRING" id="1365484.W6Q798"/>
    <dbReference type="OMA" id="GPMEQNR"/>
    <dbReference type="OrthoDB" id="440324at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015418">
        <property type="entry name" value="Eaf6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13476">
        <property type="entry name" value="CHROMATIN MODIFICATION-RELATED PROTEIN MEAF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09340">
        <property type="entry name" value="NuA4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 9" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="115"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="152"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="195"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU368022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDM32235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="228" mass="23867" checksum="3C0ED85C174F3773" modified="2014-04-16" version="1">MADTAPAPTAATATTGVAAPTAGATAGAPNAPADQNAASRGLPYYEKLRRELRDTLQKKRLMDKSMAQLEDQIFRFEQSYLEETTAGNIIKGFDNYIKGSANGSSLGAAGLGLGSSMGGSRRKAQVTESDRVFSRSSASYMMDSPGPSSVQTTPSHAATPTSTTGNGMSMKIDPLTVSAGMRNSNGASKNKKKATGGSKNTKGKNQTEDISDEDKPSVKRLKISYGRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q7A9</accession>
    <name>W6Q7A9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PROQFM164_S02g002002</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q7A9"/>
    <dbReference type="STRING" id="1365484.W6Q7A9"/>
    <dbReference type="OMA" id="NYHNERI"/>
    <dbReference type="OrthoDB" id="5329176at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="94"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="123"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="169"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="203"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="27"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="348"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="377"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM31851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="396" mass="43180" checksum="4DE6F564900981DC" modified="2014-04-16" version="1">MVDDHQHKTALGIVVAFTALGGIAVLLRLWSRWLSRSALTSDDCFIVVGYIISICQSITSWYYIKTNYVGFHIWDIPKDFNPRPGMNWNFANQILYNPALTVVKLSILLFLRRLDSRSRVVKYLTWSSFAVVITLFMTVLLVDIFQCNPVAYVYDTTIPGGKCINQGAFYVSTAALNLFTDIMVLSIPVIITARLQMPLRRKIAVCIILCLGGVATAVGVWRIVMLAQAFLSNTPNPDPTYAIGFCSSAVEINVAVVSACGPSLKAISSRIFPKLLGSSRGKSTYYGAGTGSGTGVGSRRLRSNAFKSTSHAQQSVYSTRGADYEMADPLGGPRVDVVGDFEMRKYKRGGSDSGLSSEDGKGIMKTTDISVGYSMEPRVEDGRSHDGRPASVDSIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q7R3</accession>
    <name>W6Q7R3_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S02g000408</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q7R3"/>
    <dbReference type="OMA" id="FGQGVKR"/>
    <dbReference type="OrthoDB" id="4364220at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM30259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="253" mass="28648" checksum="768D7276DC58B2A4" modified="2014-04-16" version="1">MAFKYPQFEPYGDKLIRWMENANEPGCPVSMTTLKSQNLPKSPDWNIEYEREWLSPDRIASIVGLGLRVGELIPNDLYPTESPCLRHSIIKARRNGITALVGTIAPGVLFVYSIRRYHESNDPYISDLAKIAYGTHFSLDSLKYIFMNDVQESATEPFIEEQIYPSRAGIKYPSAESQTWDYPSPEFRAIMGTPIGKVVGYFILGAFGQGVKRVARIVTFQTGLDLHKLEIRFDIEDVRGNLSLGEFDLDIIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q8B9</accession>
    <name>W6Q8B9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S02g002776</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q8B9"/>
    <dbReference type="STRING" id="1365484.W6Q8B9"/>
    <dbReference type="OrthoDB" id="4232626at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM32625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="164" mass="18255" checksum="3DC68F4E3186C01A" modified="2014-04-16" version="1">MGIHWLARRGLQISINYIEDSGPLPSRAEKRGRSSVTTRMLAGRDAQIDAEQISEYTLVKYVEQGRVLATHEDVPDSLRQQLYAAENQQPDQKKTKAADNSTMGSMCPPISIYVLPAVSSQLSLSIRTPANDDMPTRPDCTGSTMVDGLLGVTVEEYTEWQQRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q937</accession>
    <name>W6Q937_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S01g000051</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q937"/>
    <dbReference type="STRING" id="1365484.W6Q937"/>
    <dbReference type="OMA" id="CHIESSE"/>
    <dbReference type="OrthoDB" id="4505556at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM26242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="408" mass="46606" checksum="F91ECF4247F6AAEA" modified="2014-04-16" version="1">MQVPTEIYDHIVYRVWNVYNEFLYLADDARKYATFEGRARRDLANLRLVNRAFCRSASPWLFRHVNAECTSTLVTPPLERLIQLSKSPYATCVCQIDFGFKESLPSDTSTLYIEALAEWHSFLLVKFTNLRALGFHEPPLSLPQAQKAVYMEIAISILRYVPLPNLSELEVRFSITHDFGRFFPNEINSLQIPIEDILQHLRHLELCVCAYTDSADQRRRQTPVLPEYAALPNGTYAPHLFRMVENAPKLKSLILSSVNILDFDSVTFPSTVCLESLHLGGVSISSDVLLSLINQSAHKMKYIGFWLVKLKSGTWQQVLLQLCKLPRLLDINIDYGGYTLTGSSSHLADRLFPSPECRPDIETMHNLDLIELGNLQWQVNSNRIAMGLQPFPDTDYQHINKPSLEFEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W6QAG7</accession>
    <name>W6QAG7_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="12">WD40/YVTN repeat-like-containing domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PROQFM164_S03g000124</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat HIR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QAG7"/>
    <dbReference type="STRING" id="1365484.W6QAG7"/>
    <dbReference type="OMA" id="CIVSNLH"/>
    <dbReference type="OrthoDB" id="71227at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033186">
        <property type="term" value="C:CAF-1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006335">
        <property type="term" value="P:DNA replication-dependent chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000461">
        <property type="entry name" value="Chromatin assembly factor 1 subunit B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055410">
        <property type="entry name" value="Beta-prop_CAF1B_HIR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045145">
        <property type="entry name" value="PTHR15271"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15271">
        <property type="entry name" value="CHROMATIN ASSEMBLY FACTOR 1 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15271:SF4">
        <property type="entry name" value="CHROMATIN ASSEMBLY FACTOR 1 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24105">
        <property type="entry name" value="Beta-prop_CAF1B_HIR1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 9" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="CAF1B/HIR1 beta-propeller" evidence="11">
        <location>
            <begin position="1"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="10"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="59"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="117"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="159"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="CAF1B/HIR1 beta-propeller" evidence="11">
        <location>
            <begin position="308"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="217"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="430"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="549"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="233"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="270"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="431"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="549"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="559"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="604"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="627"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="648"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="663"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="679"/>
            <end position="692"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF24105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDM33400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="725" mass="76694" checksum="0C4B750EE09E3B98" modified="2014-04-16" version="1">MKATPLLISWHNDNAPIYSVHFDPNGKGRLATAGNDNNVRLWKVESTGEERKVSYLSTLMKHTQAVNVVRFSPKGEMLASAGDDGNVLLWVPSEIQTQALGEDHSDDKETWRVKHMCRSSGAEIYDLAWSPDGVFIITGSMDNIARIYNAQTGQMVRQIAEHSHYVQGVAWDPLNEFVATQSSDRSVHIYTLKTKDGQFTLTPHGKVLKMDLPAKRIASSSPAPPDVTSRSQPSTANSIAIASPAPSTPGTPMASNLPMDPPPVSHSRRSSFGSSPSIRRSASPAPSLPLPAVKPLEVSSPSLGGLGVKNASIYANETFTSFFRRLTFAPDGSLLFTPAGQFKTSHVSATDSTKTTDEVINTVYVYTRAGFNKPPISHLPGHKKPSVAVKCSPVFYTLKQGTQPAKNITLDTSSGEEMFSSLPEPVVSGNPPFTSQPHIVPPSSTTADSSKLQPSPKAAEHGGNEANHSSAPVFALPYRIVYAVATQDAVLVYDTQQQTPLCIVSNLHFATFTDLTWSADGLTLIMSSSDGFCSSLSFAPGELGQTYTGPTSVTHNVSNPTTPATNLTPLLTPTHSASSHVPSPIKTSHAPPNSTGPIPPASPARSNSACSVATQLSTQPAPAGVVNNPTPTLGTVPSVTATNSAQPPTLPMTTPPQTPISGAPQNGTTTTGSSVLGKRASESEREGSKEEPNNALQQPPKRRRVAPTLISAATDGASSSKEDKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W6QB34</accession>
    <name>W6QB34_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PROQFM164_S02g001494</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QB34"/>
    <dbReference type="STRING" id="1365484.W6QB34"/>
    <dbReference type="OMA" id="NTDDARH"/>
    <dbReference type="OrthoDB" id="5979581at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050684">
        <property type="term" value="P:regulation of mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051334">
        <property type="entry name" value="SRPK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634:SF9">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDM31344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="164" mass="18760" checksum="3C26048DA1B389DC" modified="2014-04-16" version="1">MIGQRFTSRVTKRAFISLRTKPLNLPPTGPTFAIPSHEVVDEERCPNYIPQHYYPARPGEILGNNYQLLAKIGWGTSSTVWLARDITRYRWQSERTVALKILNSCDAKSASDLLGIEETVAQKNPSHLGYYITRSCLESFELKTSDKMHLCLVYEAMREPMSMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W6QB48</accession>
    <name>W6QB48_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycosyl transferase, family 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S02g001509</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OMA" id="GITMIDY"/>
    <dbReference type="OrthoDB" id="4494951at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03801">
        <property type="entry name" value="GT4_PimA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12526:SF510">
        <property type="entry name" value="D-INOSITOL 3-PHOSPHATE GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12526">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20706">
        <property type="entry name" value="GT4-conflict"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="3">
        <location>
            <begin position="1064"/>
            <end position="1184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM31359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="1300" mass="143444" checksum="C6F98585BC27AF3F" modified="2014-04-16" version="1">MATLERARFEEDVLPTTLDKLIIPKAEDGNFALTALPEADSITEIVESVLGHAVELHRLQASGAEGQSGCSIYFVRNSSHPERTVAVTKVYPPACHKDFFEELVAYRRLISLSDPPSAARPLGVGRTRDENTAEPIGVIVYQLAAGKAINTIIRDIGRVSTLRRIAKQPCPEETREIMNDIVRGALHGISISHKTQQIQSSNIPTAEMLHCQFNGLMADLISAVQGVALTMAKLHREKSEWSSASESVVERLRNKLQGWVQEIQGPSRKQYERAIGSHKIQQLASLVDRAIEYSREEGVASLLHADASPGNFFWDPVQGITMIDYGGLTRSIDASGRPIGPAEMDAAGFHERLRKYAGDFGMSEADIGQVQREFWKAYQAQGIPINEGLARLFKTRTQLSRLWSAVEKQDTSRDEHKALQFSEKVEFEWERLVNISPEKIQPWRVLVLANASGPGKGGLPLLNQELVKAMSEIPNASVTLFMVEPENEVKNTLAWSEHGRAKVVCIPSRGADPGALLYHVAKVQQPGDYGLPIPDDQHPCPFNLIIGHSRYSSTAASLIRERWYPTAKLALITHTSALRKSDIAWKWYGQTREQGYVEAARLAMLDERILPKADLAVGVGPVLTTEAREREWMGQCNRPRSNMTGPRFHELIPGVRTGDACTQQRQPNDLFRVLLAGRADDPAKGLDDAVYAVRKIALSGNEISLDVLGLPVEDVERWQQAVDEMTGMPDLVRLHPFSDDPDAVSRFYCNADLVIMPSMHEGFGMIFTEVAGLGVPILVTQESGAGQFALDRTRIPPGLGQACVVMDESTYGIVPSPTSQRVAVWAYRIDQVRCYPEQTRRHARSLQRIMRGYSWKHAAKALLRSAMEGEGDTVQMAHGSIAPAYSSWSRPSLGMSVVSSMRRAARTRNRSGKPTLKQADEVMQNLPEIAPTISALAEHVSAAVGCPVNLRSLDPTHPGGFSGAIIFFAFANDEFTNGETTLSSNDRCKDRAVAVVKLFVHGLDNGITEELSSLEWLLLHTKGDIKTAAPLAVGQMTWDTKPAGVVTYQVAPGVSLYQLMMQMGRLPPGPARRDMLSAFIAGVQAVARTLARLHTHSVEGRPGTEYLQWYFNAATNRVQQALLYKEVIRSAGLEADQLPQKMNQLIADCRRDIASRPRTTVVHGDAHPGNFFYDCATGHITMIDTTTLHCSLDENGEPLGVPERDLGHFVHMLRRTGEQYGLTRQEMQESTTDFVEAYLGNAAAPISIEILQFLMSCSALSFLNYAAQSDQTKVELQVGILQDLFRLGEGLTQLDGMRVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>W6QB97</accession>
    <name>W6QB97_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphotransferase</fullName>
            <ecNumber evidence="6">2.7.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PROQFM164_S02g001564</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the hexokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.-" evidence="6"/>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QB97"/>
    <dbReference type="STRING" id="1365484.W6QB97"/>
    <dbReference type="OMA" id="HYPHYKE"/>
    <dbReference type="OrthoDB" id="419537at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005536">
        <property type="term" value="F:D-glucose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008865">
        <property type="term" value="F:fructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004340">
        <property type="term" value="F:glucokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019158">
        <property type="term" value="F:mannokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001678">
        <property type="term" value="P:intracellular glucose homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006013">
        <property type="term" value="P:mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd24000">
        <property type="entry name" value="ASKHA_NBD_HK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.367.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001312">
        <property type="entry name" value="Hexokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022673">
        <property type="entry name" value="Hexokinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022672">
        <property type="entry name" value="Hexokinase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443">
        <property type="entry name" value="HEXOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443:SF29">
        <property type="entry name" value="PHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00349">
        <property type="entry name" value="Hexokinase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03727">
        <property type="entry name" value="Hexokinase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00475">
        <property type="entry name" value="HEXOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51748">
        <property type="entry name" value="HEXOKINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="4 6 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Hexokinase N-terminal" evidence="8">
        <location>
            <begin position="13"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="Hexokinase C-terminal" evidence="9">
        <location>
            <begin position="244"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="453"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="458"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDM31414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="551" mass="60849" checksum="221FB271FEB13C8F" modified="2014-04-16" version="1">MTTSQISPKKHNLREFLQPLRVELETLYDLSCRLSSSYKKLAAESSEHFIPTALTCLPTGHEKGRYLAVYFGQSYLRVAFIDLLGDQHVEGHARVRRTLEKAWPIAEHLRKDHYIDLFTWIGDCIAEVVADRLANPSEERVDQITTGISFCLPIKQDSLDEAILMPTGKGFSLNSDLNLRQALLSGYDRHTYSTHGDEMNMPAKRRRLFSLPKLKVAVMINDTTATLASLAYSIPSLPNTRVVMGLIVGAGCNTTVPMKLADLHKSKTKSILEKHPDAEETLISTEWTLSTAAGPFDELGIRTTWDLQLDRNCQRPGFQPMEYMIGGRYTGELVRIVCYDWFHGVLGIPRSELPLKLVEEYSLSTDYLSLVVASSLSDERLASELSKTLQPSPESDWTWSPEYARDIRVIASTVQDRAASLVASAVVGLLDCTNEVQLCNTAPKCNNGEKVNTEAGVTEQTDSESVSSPTRGWNSGPEELAVAFSGGVIQHYPHYKETVQRYIDRLLLRAGPQVGGKSVFLREASDGGLIGTGVLAGTASGEIGEIKVTPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>W6QBF1</accession>
    <name>W6QBF1_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="8">LMBR1-like membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PROQFM164_S03g000070</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LIMR family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QBF1"/>
    <dbReference type="STRING" id="1365484.W6QBF1"/>
    <dbReference type="OMA" id="QLERICY"/>
    <dbReference type="OrthoDB" id="203099at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051584">
        <property type="entry name" value="GPCR-associated_LMBR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006876">
        <property type="entry name" value="LMBR1-like_membr_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21355">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR-ASSOCIATED PROTEIN LMBRD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21355:SF0">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR-ASSOCIATED PROTEIN LMBRD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04791">
        <property type="entry name" value="LMBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="134"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="163"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="351"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="405"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="447"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="498"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="567"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="654"/>
            <end position="680"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM33346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="680" mass="75814" checksum="DC08B0E93E900B7B" modified="2014-04-16" version="1">MFPLSVSPISVGSNVFFAFALFLISALVLLLLRRFLTLRATPAYLIVPIFLALALPASVVLLVPIDLASSSRDGSGPKAIWLPERMVLVCWRIAYWLIFVLTWVILPLLGEYVDSGYREPKGRLMYSLRSNAKYQMIVLGCALVGLIYVSISNGFEFTSIKGLVMALAYVWGLVLAIYLMGHGLVSIPRNLLRNSNVSGRLRRLQAHAPKVHDRLMDSVNELANLNGQVSQLQRRKTGTARDFQEWIEELREGHGQSDVRAPILESPDTSATIPSVITERYLADLTRRLQRARHMKTRFVDEWDRLVQLSADLQAIINSAASKKLEFAPAPRRSSCIPRVKFLTPYMRYQLYSNVIPSVRLALGAFFAVASVCIVWSEMIKSLAPHLSAVSLTVVPHWKDNPVGFGGQLTASAWLLYMCSAALVGVSDVKVWGNRALVRRNTYGESACWYAGLVARLTVPIAYNFLTFLPKEFRRTTTFYQFLGKLINLTPLGKGFDFIFPIFILLPICATMFNLYGRIKNIFGCGLAEDDDIHDVENNPAGYGMGGWREGRDLIERELNGFGSLAVSSRGGRSTWASDRDDEGSPGSSRLRLPVAEGSQPAQRTVVAPTIVEGEDEEDEGFFQSFAHRVKNTFDTTSTPRWFQGEPFRLPRWMSGDNNPTEEASALFGGRDVPGRLRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2024-10-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W6QBV5</accession>
    <name>W6QBV5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S03</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S03g000260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QBV5"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM33536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="63" mass="7612" checksum="F1AB4FA84355C091" modified="2014-04-16" version="1">MPYVAMRKFSEEGDRKWRNGWEGKAAESRIKRGGEEGEQEKQSMGEREKRRRRRGEEEEKGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W6QBZ7</accession>
    <name>W6QBZ7_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S03g000947</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QBZ7"/>
    <dbReference type="STRING" id="1365484.W6QBZ7"/>
    <dbReference type="OMA" id="PINKGRE"/>
    <dbReference type="OrthoDB" id="426718at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021838">
        <property type="entry name" value="DUF3431"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37490:SF2">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37490">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11913">
        <property type="entry name" value="DUF3431"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004881919" evidence="1">
        <location>
            <begin position="30"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM34223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="313" mass="35565" checksum="56F249AF07E916D5" modified="2014-04-16" version="1">MRLSLRVSAAAALIILTLVLVCRNLKTKGESLQDIWHFDTGSFRTSLRPKPQPDPSQRKWRVASDRKPALVYQTTDIVVPNQGAIVMAKLKEEDTAWVGAELAEWRSVIYTVDDINAPTHTPKNKGREALPYLKYLVDHYDDLPDIVVFLHSHRDGLLAGWHIDTMDYSNVDSVRALQKEFVQQAGYVNLRCQLSPGCPSAIQPFRQPPNPESKGEAHYAAAWKELFPGEPVPKEVAGPCCSQFAVSREQILQRPHSDYQRMYDWVMNNELPDDVTAAIMEYSWHIIFGKDPVFCPDLFQCYADVYGEEVIFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2024-10-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>W6QC36</accession>
    <name>W6QC36_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S03</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S03g000360</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QC36"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM33636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="56" mass="6394" checksum="6F193FD6BE79974E" modified="2014-04-16" version="1">MLLRQSNKIKRGSVTQFRFNYLCFFSPRALKQVSGQASSRPSSILLDTFPSIQTLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W6QC59</accession>
    <name>W6QC59_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="4">N-acetyltransferase ats1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ats1</name>
        <name evidence="4" type="ORF">PROQFM164_S03g000977</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QC59"/>
    <dbReference type="STRING" id="1365484.W6QC59"/>
    <dbReference type="OMA" id="QSEWVRY"/>
    <dbReference type="OrthoDB" id="7305308at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000086">
        <property type="entry name" value="Acetyltransferase, GNAT family, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051016">
        <property type="entry name" value="Diverse_Substrate_AcTransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10545">
        <property type="entry name" value="DIAMINE N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10545:SF29">
        <property type="entry name" value="GH14572P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="3">
        <location>
            <begin position="27"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM34253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="178" mass="20054" checksum="DD86F3B877ECCF57" modified="2014-04-16" version="1">MDYLRPLSNAMADQPTIHVPLILQFICELADYEKALHEVEATEESLLATLSFPGTPPRRGAVYTALITPPATADTPNPIPVGMALYFYNYSTWRSAPGIYLEDLYVQPSARGNGYGFKLLKYLAKQVLEASGRRLEWSVLTWNEPSIRFYEQVGARGMDEWMKMMVEGDALTRLAEDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W6QD78</accession>
    <name>W6QD78_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S02g002295</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QD78"/>
    <dbReference type="STRING" id="1365484.W6QD78"/>
    <dbReference type="OMA" id="HEVYRKQ"/>
    <dbReference type="OrthoDB" id="5413982at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23313:SF0">
        <property type="entry name" value="TESTIS-EXPRESSED PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23313">
        <property type="entry name" value="TSEC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="260"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="313"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="451"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="463"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM32144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="654" mass="72611" checksum="D1BF99D8515FB32C" modified="2014-04-16" version="1">MADDAERIKAEKLAAAKKRVAQLQKKKKAKKTTTGADTPKDAEVSAETEPAEDAPSPETPQADTPAEEKDEPVAQPEATASEQAEELEEPKSQLAVDTNTESPTEPMPPAPTSPGPDAEPLPVRLDTPRGNHGRHASLSIQSKMRSSSFRKTSVSHGSVSPSPSSATLKSPSQSLPPLTGDGESVHEVFRKQSTKIEELEKENKRLEKDLSEATLRWRKTEEQVEDLRDASVDSVGLREQLKNAEEKVASIESLKEEIASLQRQNSQLQTRSHRNTTTTESPPADLVLQLESKSATIESMELEISNLRAQVASQTSSNDAHESQVAALEEKVSKTQSALDQSQRELADTKQALTRASEKAVKEGVDKTSTETLVKNLQREIEEYKNEKSESEKKIETLDKKLQAIGNLHKETEARHQTRLRESEKSDKEIAVMRKKIASIENENLRLREESDRIRTRQTSGGADDEALDELEDEERQRLERRIRELEGEVFDLRRGVWQEKRQEMEYYPDDGPSAVSGDAANAFDDVDLVGGRPDHARRRSMAQQQQHSSFSTVLSSGFAAFTGVGGNRAQTSSPHPPGTRGSLELVSEENLDDEFDEDAFARALAEEEARKRVEWMRDIKSKLRDWNGWRLDLVDSRAGAEGAGVGMGEIFEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W6QD81</accession>
    <name>W6QD81_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Ribosomal protein Rsm22, bacterial-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PROQFM164_S03g000745</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Mitochondrial ribosome (mitoribosome) assembly factor. Binds at the interface of the head and body domains of the mitochondrial small ribosomal subunit (mt-SSU), occluding the mRNA channel and preventing compaction of the head domain towards the body. Probable inactive methyltransferase: retains the characteristic folding and ability to bind S-adenosyl-L-methionine, but it probably lost its methyltransferase activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QD81"/>
    <dbReference type="STRING" id="1365484.W6QD81"/>
    <dbReference type="OMA" id="CTNHSTC"/>
    <dbReference type="OrthoDB" id="421327at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052571">
        <property type="entry name" value="Mt_RNA_Methyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015324">
        <property type="entry name" value="Ribosomal_Rsm22-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13184">
        <property type="entry name" value="37S RIBOSOMAL PROTEIN S22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13184:SF5">
        <property type="entry name" value="METHYLTRANSFERASE-LIKE PROTEIN 17, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09243">
        <property type="entry name" value="Rsm22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="741"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="42"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="744"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="768"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="798"/>
            <end position="817"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00045681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM34021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="827" mass="93291" checksum="11FA20F6A3AFC933" modified="2014-04-16" version="1">MLSWSSASGASRSQSRELFHTFSRPSGSRQLRGPANRVIPTPQRTFIQKSSPLVASSSLAHRRNTSAQCQPQRRFLSGPVSADLPPQPSQSTEPDDINILIDRIGENEAEMVQILEELEIMGEEGERDELMDLIAQRDEHTAESWVHMIKQRFGDEMPEGLLDDAELQIYARLYGEPIIRREVEETVEEEEDLSLLREDGQGGWEEVDLEGNAVAEDEAPLVYDMEFSPEERETLAMQRTREVAEQLGGEVMLEEFENEAVPDSAPRMHPLTLEGKYGTDPSTIHLPQDTVTGPISVILSEFSNKHISETARRLFGGPGLPHSSTTAPPRAQLPQLPVALQASQRQMGEMEANAYLAALYPGIYASTLSVMVEIRKRLGVDWIRRLIAQEGGPNVLDANGGGAGILAWRDIIRAEWELMVPDHPAGAPIPFGRSTVLTGSDALRLRASAILENTTFLPRLPDYVHVRGKPTIDDSRKAPKRKQYDIIIAPHSLLGLEEEYERKQHVENLWSLLNPNGGILILLEKGRQKGFEAISGAREMLLKRHIASPGSTEFDNFLEDPDQREVIEKERGMIVAPCTNHSTCPMHNSAGATKGRRDYCHFEQRYIRPPFLQRIMGAKDRNHEDLKFSYLAVQRGVDLRQEQAIRQDSQATDAAFEGFEDPEESDIPNKPAFHALSLPRAIYPPMKRRGHVIFDLCTPAGKIERWTVPRSYSRQAYRDARKSHWGDLWALGAKTRIPRNLNLGDKHGEGKKERLARRVATKNSMRDAEEEGDFENEGEEEDEDYTVDDSDIPDVPVKKRGQHIPSWKKHNDKKKLRQVYNKRSADE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W6QDT6</accession>
    <name>W6QDT6_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 16">Non-structural maintenance of chromosomes element 1 homolog</fullName>
            <ecNumber evidence="4 16">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">PROQFM164_S03g001595</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Acts in a DNA repair pathway for removal of UV-induced DNA damage that is distinct from classical nucleotide excision repair and in repair of ionizing radiation damage. Functions in homologous recombination repair of DNA double strand breaks and in recovery of stalled replication forks.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="16">Component of the Smc5-Smc6 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 16">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the NSE1 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4 16"/>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QDT6"/>
    <dbReference type="STRING" id="1365484.W6QDT6"/>
    <dbReference type="OMA" id="WPGDKFV"/>
    <dbReference type="OrthoDB" id="185455at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030915">
        <property type="term" value="C:Smc5-Smc6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16493">
        <property type="entry name" value="RING-CH-C4HC3_NSE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000640">
        <property type="entry name" value="DNA repair protein Nse1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011513">
        <property type="entry name" value="Nse1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014857">
        <property type="entry name" value="Nse1_RING_C4HC3-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20973">
        <property type="entry name" value="NON-SMC ELEMENT 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20973:SF0">
        <property type="entry name" value="NON-STRUCTURAL MAINTENANCE OF CHROMOSOMES ELEMENT 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07574">
        <property type="entry name" value="SMC_Nse1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08746">
        <property type="entry name" value="zf-RING-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 16" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12 16" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="13 16" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14 16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="10 16" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="11 16" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 15 16" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="18">
        <location>
            <begin position="238"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="153"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="291"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="159"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="297"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU368018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CDM34868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="329" mass="36614" checksum="72223FA4F3818A5E" modified="2014-04-16" version="1">MVENMAGYNDSNRAFLQAFMARSSMTFEDAQPILAAILTVSEGRTVDPDEIEKDQFSDFIAAANTAVSPFDLEIRSLLPQVIEPAQQDAPATPPKRVYALVNTTSDPLTQLATTYSPDEIAFLKRLLDFMFAKNNTRLCEGMVASQMQAVSLHKAPSGERQSTSNDSAQSQTAAVQSLRMTQAETLVIHLIEEGWLQKSAKGYLSLTPRALMELRGWLVLTYNDESFDGRAVERIKFCAACKDIITVGQRCEDRDCKGRLHDHCMRNFFRMQQAEKCPLCKADWPGDNFVGERAITNPKQRNTVPQQRRSSSAASSAVGEGLDDEEDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W6QE05</accession>
    <name>W6QE05_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g001618</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QE05"/>
    <dbReference type="OMA" id="SYEREQT"/>
    <dbReference type="OrthoDB" id="5426872at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM27807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="168" mass="18197" checksum="84A6662EA50EECC5" modified="2014-04-16" version="1">MATQGPQALPPVTVRNTHVISQSAAHEFLAAYLDRAATDPSLQPNASISEHGPVSRTTTAAPNLILHNLKRVQMGLAGEFLGRDLTVAKQNPGEDYLDVAAGIPQTNGHDLPDESNDLVMNDAEFGMEAEAFADQEAGIDKEERKRKKKERRLAEKKGKAKAKAEESD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W6QE17</accession>
    <name>W6QE17_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N-acetyltransferase B complex, non-catalytic subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g001633</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MDM20/NAA25 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QE17"/>
    <dbReference type="STRING" id="1365484.W6QE17"/>
    <dbReference type="OMA" id="WKRREHQ"/>
    <dbReference type="OrthoDB" id="1874341at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031416">
        <property type="term" value="C:NatB complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019183">
        <property type="entry name" value="NAA25_NatB_aux_su"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22767:SF3">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 25, NATB AUXILIARY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22767">
        <property type="entry name" value="N-TERMINAL ACETYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09797">
        <property type="entry name" value="NatB_MDM20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM27822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="930" mass="105502" checksum="22B22FCDC8F35FA0" modified="2014-04-16" version="1">MSSSNDAVFLRRNNQIQDAIDSQNMKQALQLIEKRMKKGENTHFLKATNVLFNHADVTHKKKGIAETLELCKADPPISDLDSLDILHSTLRNMDDYTELRSAIWERAAKAKPQDRDLQMRWFKLGYEAGDWKSAQKAAMSLQKNFPRERKYYFWAIFLCYLVSDDKSSSDMDRKLFGTLAYRLAQKAVAEVPSNPTELLSPPRAIQTAEELLLVVRILESQSRWAEIVQVLNSENTGLSSRIVNNDRTFMLAKVTSLGAAELWEEGHSYVKGLLTVPEDEAERKTLHERDDWKYWNLLILAVRRLEKSPGPKSRNAHIAIMDIVLTGFKRGERTEDDLVIACQRYFDQHKHKLYAFKDLRGVLETRDDALIHRVAQNCLDSVEGKPDDAIPLINAYKLQYCDRISANKNVLKSSIETLVRNCLYFYDAFTLLAKTQDKKQESQPDTASAMESRPTDDFCIIAAMALLQPNTAGQASEKVSNTALIRAAGILEHLLIDSPHNYEAILMLIRIYLLLGAGSIALRWFGKLSIKQMQYESVAHNLFTRFATIHPHPAPLIEGGEYKDFDAQVAFITALDFYRHASFTINNSLIKGLDDGTYVNLDDTIELQKRIRDSICRRMWALDLRRMQRIRKGNHLALHEEIAQNTSPAQDQRKYDGFMDLERCGKPAFEHRLRAGPVPGENWLASARFTDRLFSVLESIGSQKPVVLEPELPDIGKLSLSQTDVDHTGAEIDAAKIHVELLKVAMFMAGSKAHTSTEIETVLGEIEDWLKAKKEDLALEDTGNSPLIMRTTVHFSPGTPGAPTWEYFHTIWTLVETLKALCNIFNLNSRKAVKTAKLPAEQMNGLNTLVREVFEDIRLNTRSLKQSLIESATLSTLIDMVKRGDTTDEYEKPLQEVLEKAMDESALELFCGELRESWEEALDGVLAARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W6QE79</accession>
    <name>W6QE79_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g001703</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QE79"/>
    <dbReference type="STRING" id="1365484.W6QE79"/>
    <dbReference type="OMA" id="SVWITEA"/>
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    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="392"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="392"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM27892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="508" mass="56269" checksum="95ABBE9AA82A8EFC" modified="2014-04-16" version="1">MAQTLDLGKSTLRIRDSKLQLRLAASAHFNQSPSHPTPEIPIDLSQLSNLESIWITEAPELELRFWIGGNWDQNEAAAFISKLRDKLCDMEIWSDLGFSVELKRYCIETSGFHFLQLGMHRGCLARNHTTGRTLPGSMTNPPDARPPPGVPVATLASIDVRLEYRFQAKDVSQAEDCSVLEVSLLGQGTSVVSSPHVLEEMVETKILLPMHDENSYAAVRQQTVRISGKRSPSSEELFRLFDLGIQRLIISNSIKDPTVSVSQKSTIKSFADIFPAVFDPGYRDAMNQRGVTIPMITKAISSLVVGNKNLSTKAKLADLLELTSSHQTGDLAIQPQLPSCNNAVLSSLWCVAQNNVPRIKPRRRGVSMLFTEFPSNALAGLDELVDLTSIDQHQPDNENPGQCHSSQTKYHDENEESDVCLLNSESEDQLLDNFSETSFTDIGESTQISLDTLLSTTGSSQTSYGDRDAMLLSDHGELADYPENYVIDYDPREDMEACDADIIMADYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W6QEN5</accession>
    <name>W6QEN5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Major facilitator superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PROQFM164_S04g000069</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QEN5"/>
    <dbReference type="OMA" id="RIMLYIM"/>
    <dbReference type="OrthoDB" id="196103at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06178">
        <property type="entry name" value="MFS_unc93-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051617">
        <property type="entry name" value="UNC-93-like_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294">
        <property type="entry name" value="ET TRANSLATION PRODUCT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294:SF59">
        <property type="entry name" value="UNC93-LIKE PROTEIN C922.05C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="81"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="167"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="205"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="259"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="296"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="326"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="375"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="439"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDM35188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="496" mass="54955" checksum="12AF30133E4E8A1E" modified="2014-04-16" version="1">MDERKTPVESSSEPEYIPRPAGWMYKSGKIGKFSTGWYASPRIQLGMVAFVCFLCPGMFNALSGMGGGGKSDPSLADKMNIALNSTFAVVGFFAGTVVNRVGVRLSLSFGGIGYCIYSISLLVSEHRYVPGFNIFAGAFLGVCAGLLWGAQGTIMMSYPTEQQKGRYFAWFWAIFNIGACIGSLIPLGQNIHVTSNKTVGDGTYIAFIVLMFAGACLALFICDADKVVRTDGSRVILMKHPSWKSEIVGLWETVRSEPWIVLLFPMFWSSNWFYTYQQNSINGAYFNTRTKALNGFLYWFAQIVAACIMGPLLDSERVRRTIRARAALVGLFILTVVIWGSGYAWQRRYTREDVDAKITGFQGWDWTTKGYVGPMFLYFFYGMYDAAWQGVVYWIMGALGNSGRKLANLAGFYKGLQSAGAAVMWSLDEKKLPYMNEYASNFGLLCGSILIAVPVVFFKIKDSVPVEDDIQGTDETLEDVLPLGAVESKRVGEEKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W6QF00</accession>
    <name>W6QF00_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g001968</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QF00"/>
    <dbReference type="STRING" id="1365484.W6QF00"/>
    <dbReference type="OMA" id="IHHIIAC"/>
    <dbReference type="OrthoDB" id="3527137at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056672">
        <property type="entry name" value="DUF7770"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24968">
        <property type="entry name" value="DUF7770"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7770" evidence="1">
        <location>
            <begin position="34"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM28157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="175" mass="19465" checksum="3854FCCAC717DA74" modified="2014-04-16" version="1">MSNFRPVHFVPANRQAEMLALPVLKIFAVPHQQQAGTNHWCFYLMTSSDTSVQIDCQPSYTEPSSVLRGGSKANLVVSELSCLVPNDAQERFELDITPGLLVGQVYDLIIQNARHKYEFDMDGVGCRCWATGQLGLFHQAQIITNESQVAATKAAILKLWPEQTPLPLDQGAYYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W6QF47</accession>
    <name>W6QF47_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S03</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S03g001837</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM35110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QF47"/>
    <dbReference type="STRING" id="1365484.W6QF47"/>
    <dbReference type="OrthoDB" id="4365430at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="130"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM35110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="200" mass="21890" checksum="9EFB16201CB6C713" modified="2014-04-16" version="1">MNGLDRSHESVNNLTRFSFGDAEDVITSVARTLCLYLMAFRSPARGQEWRNSARPELPLWTTSFDHTHSQIPKAQPPQTLPHSDSTTLKYTSLDSGSAYEPPSSPPDSPKAVAHRVPTRSQTSCAPSAVQRRSQSPDSSGSNSNQAIGHKRASTKLHPPHLPNEQVINGTREIIKATRPGITMRNFAPNDVYSDCSLAVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W6QFD2</accession>
    <name>W6QFD2_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PROQFM164_S04g000379</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QFD2"/>
    <dbReference type="STRING" id="1365484.W6QFD2"/>
    <dbReference type="OMA" id="DMCCAAD"/>
    <dbReference type="OrthoDB" id="5327538at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072354">
        <property type="term" value="F:histone H3T3 kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000961">
        <property type="entry name" value="Putative serine/threonine-protein kinase haspin homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024604">
        <property type="entry name" value="GSG2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24419">
        <property type="entry name" value="INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24419:SF18">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE HASPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12330">
        <property type="entry name" value="Haspin_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01331">
        <property type="entry name" value="DUF3635"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Serine/threonine-protein kinase haspin C-terminal" evidence="10">
        <location>
            <begin position="489"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="80"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="154"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="572"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="108"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="182"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDM35498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="657" mass="73759" checksum="B867BAE428411998" modified="2014-04-16" version="1">MSTRSHSPVSSHATPMEPKQSKPKSVAQRRVYGKRRANAPRAVFDHGSPARDTRSKTQYLDPVESLQAKLAQVAIDDDSTLQQDNYTKPIKTESEQEQELTEIPLGESSPSTIEDTSDTLTPRSSFESFSEQSKLEPKKCETMVEVRICPKNPGILPQAIPDSPAMMPESTSEDREKPSTSSRRRAERKKIPAPRRSSGVVHDSKASDYVSPILNEALSPIAAQGIQKFSSWASRSANMFHVAKLAEGSYGEVYKLHLREEACRPVVSKSKLAKLKSYGDGVFKVVPLRAKSGPGSKKFTTIDEIVSEVKMLKYLDPIPGFARFREIHVVQGRFPESFQNAWDHYKKTKDDCLNPNPSNKRAYPDTQLWAIVEMDDAGCELEKFAWSSIFQIYDIFWGVAMALARAEEYAMFEHRDLHLGNVCIRSTREDGCLDPPTEFDVARQSSCSGFGISSLETTIIDYSLSRADLLLTDDPAGLTEVASSDLDKKQLFDAIGQDEDEIMQRNTYRYMRATLYTGCPIETEKVADIPGIWAEYSPRTNLVWLLFLLQSLFKNRKPEALFVQPQRKALAPCSPNRMTPKPETSKGKDQNMAGSLKERQSKDVQASISRLKQALEGRLKAVLELLDLEHGHEDMCCAADLVAYAMDSRWLSEQDFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W6QGA0</accession>
    <name>W6QGA0_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Heat shock protein DnaJ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PROQFM164_S03g001723</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Endomembrane system</location>
            <topology evidence="5">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QGA0"/>
    <dbReference type="STRING" id="1365484.W6QGA0"/>
    <dbReference type="OMA" id="RYIRHAR"/>
    <dbReference type="OrthoDB" id="413400at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052606">
        <property type="entry name" value="DnaJ_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44653">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44653:SF2">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0346">Stress response</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004880203" evidence="8">
        <location>
            <begin position="19"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="163"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="9">
        <location>
            <begin position="42"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="240"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="347"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="243"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="348"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="373"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDM34996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="383" mass="42778" checksum="A8884D2D95532EE1" modified="2014-04-16" version="1">MKPFAFLSLFVFFGLVAAWSKEDYEIFGLQNDVATNEGANVTFYDLLEIRPNANQDQITKAYRKKSRTIHPDKVKRAFIANYAKDKNKAKSNQGVNVNKGPTQREIDAAVKNADARSARLNLVANVLRGPNRQRYDHFLKNGFPLWKGTGYYYSRFRPGLGSVLVGLFLVFGGGAHYAALILSWKRQREFVDRYIRQARRAAWGDELGVRGIPGIESVAAAPPPPAPESGDVGAVAVNRRQKRMMDKENKKDKKGGVRVSARAPDASTAEQTASTGERKRVVAENGKTLIVDSIGNVFLEEQNEAGERQEFLLDIDQIERPTLRETMVCTLPIWCFNKTVGRVLGTAPEEEVDSEAEEPLVEEAETTATSNSRSRKRGKRSQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W6QGR7</accession>
    <name>W6QGR7_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Probable catabolite repression protein creC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">creC</name>
        <name evidence="11" type="ORF">PROQFM164_S04g000042</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the regulatory network controlling carbon source utilization through ubiquitination and deubiquitination involving creA, creB, creC, creD and acrB. Required to prevent the proteolysis of the CreB deubiquitinating enzyme in the absence of carbon catabolite repression. CreB deubiquitinating enzyme stabilized in a complex with the CreC leads to the expression of genes such as those in the proline and quinate pathways.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Interacts with creB.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the WD repeat creC family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QGR7"/>
    <dbReference type="STRING" id="1365484.W6QGR7"/>
    <dbReference type="OMA" id="MCVCWSP"/>
    <dbReference type="OrthoDB" id="3367at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045013">
        <property type="term" value="P:carbon catabolite repression of transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000531">
        <property type="entry name" value="Probable catabolite repression protein creC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051362">
        <property type="entry name" value="WD_repeat_creC_regulators"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14107:SF16">
        <property type="entry name" value="AT02583P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14107">
        <property type="entry name" value="WD REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="1 9" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="367"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="471"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="479"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDM35161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="564" mass="62809" checksum="C8061856B6FB98A7" modified="2014-04-16" version="1">MFVLPPPPPRYTIPVAYAAGAANGMAVPVLEMNNTITHPERGCPLQVGEGTYTLQDDLLLATPPPHPSEAPIINPNPLATLPTPPTTGVKLSLVTLDPRKKPPTFLKSGITVPQFGDENPALAAPPVAAKDAAKRRKPKNNIIKSSSSFVSRVITHETSAKRLSDRDPNGVFAFANINRAFQWLDLSSPTKEEHLTKVLFTKAHMLCHDINELTKTSSHLDIVMGSSAGDIIWYEPMSQKYARINKNGVVNNSPVTHIKWLPGSENLFLASHANGVLVVYDKEKEDALFTPEVNDHSEQEIGRLPLDILKSVNSKNQKTNPVSFWKMANQKVSSFSFSPDQRHLAVVLEDGSLRLMDFLKEEVLDIFRSYYGGLICVCWSPDGKYIVTGGQDDLLTIWSFPERKVVARCQGHNSWVSWVAFDPWRCDQKTYRFGSVGDDCRLLLWDFSVGMLHRPRAHHASSRNRSSIVVPNSQIANRHRADSGDNRVRSDSNETDKFNEDLDQTTSHPVEPKSRTALLPPIMSKIVGEDPICWLGFQKDCIMTSSLEGHIRTWDRPSDSVIKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>W6QGU7</accession>
    <name>W6QGU7_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">D-xylose reductase [NAD(P)H]</fullName>
            <ecNumber evidence="2">1.1.1.307</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PROQFM164_S04g000934</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the initial reaction in the xylose utilization pathway by reducing D-xylose into xylitol. Xylose is a major component of hemicelluloses such as xylan. Most fungi utilize D-xylose via three enzymatic reactions, xylose reductase (XR), xylitol dehydrogenase (XDH), and xylulokinase, to form xylulose 5-phosphate, which enters pentose phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>xylitol + NAD(+) = D-xylose + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27441"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17151"/>
            <dbReference type="ChEBI" id="CHEBI:53455"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.307"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>xylitol + NADP(+) = D-xylose + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27445"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17151"/>
            <dbReference type="ChEBI" id="CHEBI:53455"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.307"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.307" evidence="2"/>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM36053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QGU7"/>
    <dbReference type="STRING" id="1365484.W6QGU7"/>
    <dbReference type="OMA" id="YCLQKNW"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19071">
        <property type="entry name" value="AKR_AKR1-5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000015">
        <property type="entry name" value="Oxidoreductase, aldo/keto reductase family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="2,5-DIKETO-D-GLUCONIC ACID REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827:SF13">
        <property type="entry name" value="ALDO_KETO REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00063">
        <property type="entry name" value="ALDOKETO_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="10">
        <location>
            <begin position="29"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="9">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDM36053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="283" mass="31046" checksum="6A6EDE11C17882D4" modified="2014-04-16" version="1">MSASFKITDLLPLPKSSVGIPRLGFGVYRSPPNQCVQSCLKALEAGYRHIDTAQFYANEAEVGEALRTTSVPRDQIFVTTKILSPAASVEATYDKLLASVHKIGGADGYVDLFLIHSSSSGSAGRKVLWQALEKLYASGKTKSIGVSNFGVGHIEEMRSYAQVFPPHVDQLELHPWCQQRVIGEYCQKNGIILEAYSPLVRNYKANDPTLVEVAKKYGKSTQQVLIRYAMQKGWVPLPKTDNPERIVSNADVFDFDISVEDMAVLDSFDQGSAGAIVEAVDNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2024-10-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>W6QIB9</accession>
    <name>W6QIB9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S03</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S03g000663</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QIB9"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM33939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="68" mass="7440" checksum="855E705F6027B420" modified="2014-04-16" version="1">MNRRLGSCKIQNPLGSDVIPNEEKGGEIPTKAIKVDCERIELMELMGSMESMGTDMGTLVFLPVLAPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W6QII6</accession>
    <name>W6QII6_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S03</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S03g000738</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QII6"/>
    <dbReference type="STRING" id="1365484.W6QII6"/>
    <dbReference type="OMA" id="FVRRCFP"/>
    <dbReference type="OrthoDB" id="3533623at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="380"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="381"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="405"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM34014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="468" mass="52467" checksum="0A9694C2DB12FFF9" modified="2014-04-16" version="1">MSPDPYYETLDAPDGTALTWIFDHCLRYADSYEISLRAAYELNCHPSKSTMTPSFIPRSPSIFRDTVWSKKGHNSKSSVDAPSYDTNAEFRACLSKTVAEVPSQPCALPPSFIISFVRRCFCLDLSEVDFAQALTALDYIRTLQNRWKKEIDAAFNRLNVTSEDARDPEHSEVARNYPNLLTWYENISNKARTIDFLYTQVYIGLRRWVLVNQMMLEPFDKANCLALLNTLLPPVHRDSSTPTQQLSTATLGLYRDTFFKYITTFEADPSIVEPIIQQGAAPGDENGWPALHATIERYMNAALEMIDECVLINEPCQITKSGVQRRTDSGISFGVDFGPCPTISHSSDTEKPLPHFPEPTIGTSKHGSFLERFSSLSAWGKKKDPKKEQQKEFARSLKKMQSLGKLTSPTSSAKSSTKSIKSVKTPPKFKANISFDLTEDKRRRLIDEAQARKAVGATEAAESIGQAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>W6QIZ4</accession>
    <name>W6QIZ4_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Transaldolase</fullName>
            <ecNumber evidence="3 9">2.2.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">tal1</name>
        <name evidence="10" type="ORF">PROQFM164_S01g003374</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the rate-limiting step of the non-oxidative phase in the pentose phosphate pathway. Catalyzes the reversible conversion of sedheptulose-7-phosphate and D-glyceraldehyde 3-phosphate into erythrose-4-phosphate and beta-D-fructose 6-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>D-sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-erythrose 4-phosphate + beta-D-fructose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:17053"/>
            <dbReference type="ChEBI" id="CHEBI:16897"/>
            <dbReference type="ChEBI" id="CHEBI:57483"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="2.2.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Carbohydrate degradation; pentose phosphate pathway; D-glyceraldehyde 3-phosphate and beta-D-fructose 6-phosphate from D-ribose 5-phosphate and D-xylulose 5-phosphate (non-oxidative stage): step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transaldolase family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.2" evidence="3 9"/>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QIZ4"/>
    <dbReference type="STRING" id="1365484.W6QIZ4"/>
    <dbReference type="OMA" id="THAEFLW"/>
    <dbReference type="OrthoDB" id="2015515at2759"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00414"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004801">
        <property type="term" value="F:transaldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009052">
        <property type="term" value="P:pentose-phosphate shunt, non-oxidative branch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00957">
        <property type="entry name" value="Transaldolase_TalAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000088">
        <property type="entry name" value="Transaldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001585">
        <property type="entry name" value="TAL/FSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004730">
        <property type="entry name" value="Transaldolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018225">
        <property type="entry name" value="Transaldolase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00874">
        <property type="entry name" value="talAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10683">
        <property type="entry name" value="TRANSALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10683:SF18">
        <property type="entry name" value="TRANSALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00923">
        <property type="entry name" value="TAL_FSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01054">
        <property type="entry name" value="TRANSALDOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00958">
        <property type="entry name" value="TRANSALDOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0570">Pentose shunt</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0704">Schiff base</keyword>
    <keyword evidence="5 9" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDM29562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="324" mass="35559" checksum="DFF5D5CE22FD135B" modified="2014-04-16" version="1">MSSSLEQLKATGTVVVCDSGDFATIGKYKPQDATTNPSLILAASKKPEYATLIDTAVAYGKKNGKTLDEQVEATLDRLLVQFGKEILQIIPGKVSTEVDAKLSFDTQASVNKALEIIKLYADNGISKDRVLIKIASTYEGIKAAHILQSQHGINCNLTLMFSLVQAIAGAEAGAYLISPFVGRILDWFKAAHKRDYTPQEDPGVKSVQDIYNYYKKFGYKTIVMGASFRNTGEITELAGCDYLTISPNLLESLYNSTEAVPQKLNAADASNLDIKKREYLNNEAQFRFDFNEEAMAVEKLREGISKFAADAVTLKELLAQKIQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W6QJ95</accession>
    <name>W6QJ95_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S03</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S03g000983</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QJ95"/>
    <dbReference type="STRING" id="1365484.W6QJ95"/>
    <dbReference type="OMA" id="THEGPYE"/>
    <dbReference type="OrthoDB" id="5371016at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM34259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="199" mass="21984" checksum="0D23EB6EEA3125FE" modified="2014-04-16" version="1">METTVSIYHGPYESIPDNASPGLKFLKRFLPALDSLTPGENVISPFFTSSAPILIASDPPTTASQAVPILEVRSRHTSKFHHHVDLAWDIDLRGDTGPINTSYSRTAPNADAAQKGQLYAPLVGNIQMKRTVMFEATSETTFREDPCQFAVRVREFNILDLEGRDESDLQIVEMRIFLDQRPLQAHSASLFTGSGYSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>W6QK83</accession>
    <name>W6QK83_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Endonuclease/exonuclease/phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PROQFM164_S05g000239</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">FM164</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the neutral sphingomyelinase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QK83"/>
    <dbReference type="STRING" id="1365484.W6QK83"/>
    <dbReference type="OMA" id="IEESSMF"/>
    <dbReference type="OrthoDB" id="387657at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004767">
        <property type="term" value="F:sphingomyelin phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006665">
        <property type="term" value="P:sphingolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.10.10:FF:000059">
        <property type="entry name" value="Inositol phosphosphingolipids phospholipase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038772">
        <property type="entry name" value="Sph/SMPD2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16320:SF24">
        <property type="entry name" value="PHOSPHODIESTERASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16320">
        <property type="entry name" value="SPHINGOMYELINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="16" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-0540">Nuclease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="402"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="428"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="15">
        <location>
            <begin position="16"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="341"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="344"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CDM36406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="495" mass="55294" checksum="79230B4C4108081B" modified="2014-04-16" version="1">MAYSIPSKAPTDIRVLTFNCWGLKYIAKYRHERMSEIGRQLAIASPPPEIVGLQECWTQKDYESIRDQTRHILPYGKFYYGGIFGAGLAILSKWPIEESSMFGYPLNGRPTAFFRGDWFVGKGVASARVRFGPGTADVAEVFCTHLHAPYEREPNDSYLCHRTAQAWEISKLMRGAAERGHLVIGLGDFNMVPSSFAHRLITTQSPVRDAWRELHPDSSLAAAIDPAEQARNRPIPTAEFNLTENGATCDGAFNTWRWTEAMRKRLVKGEDIEIDNETPDPRAKRLDYIFIGDGGYPPAFPPSSWSVQSVQISMTQRHPTLLCSLSDHFAVEAVITRSSVRTYPPSHSSDSAPSSPTSPSLHETTSKPVSPNAALSPDTYDHIIDMTHTYVARERSQRRWRLAHFLVSIVISIGCMVGVWWIGNRTYIGFILILVSTLNFAAGVLDGLIGGLFMSGELRALKEFEWEVRNARNLVVAAENRVGATSEERDGDQKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2024-10-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W6QK91</accession>
    <name>W6QK91_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S05g000648</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QK91"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM36815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="40" mass="4387" checksum="E7ABAAA75C87F168" modified="2014-04-16" version="1">MESQSIFQNSFSDNPSGHQGELKKKLGFVSMLGLAFIVLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W6QLQ5</accession>
    <name>W6QLQ5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="6">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PROQFM164_S05g000749</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QLQ5"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="127"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDM36916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="277" mass="31118" checksum="AE39DAA3C152C532" modified="2014-04-16" version="1">MDPRSLIHPSYKESVSPFTLMHWSYPALLYMMRSVGGKPSSLGAYSHSSANLSYTSFKLPQLLVGRIIIGMGIGTVFTMVPYGTIKATNRGKNVVIDGIFITSGNSMLLEQFWLFSYRRPVRVMDSFLEIPAALSLVLIIFIFFFPGLPRRLVLIGQGKQSVKELTRIRLKSMYRKSDARSHLSIFLRKPLKLPLPSKISSPCRMEAILPFCAVSRLAGLNSSDRSTLQPSPSRTWDFRDNCPVFRSSSLRSLYSSLLTIFIDGGCSYFVEMASRFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>W6QLT4</accession>
    <name>W6QLT4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="10">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PROQFM164_S06g000367</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792020">
        <property type="protein sequence ID" value="CDM37405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QLT4"/>
    <dbReference type="OMA" id="MAIIVSC"/>
    <dbReference type="OrthoDB" id="6339427at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015798">
        <property type="term" value="P:myo-inositol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015791">
        <property type="term" value="P:polyol transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000134">
        <property type="entry name" value="MFS sugar transporter protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050814">
        <property type="entry name" value="Myo-inositol_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020:SF9">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020">
        <property type="entry name" value="PROTON MYO-INOSITOL COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="70"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="166"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="200"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="228"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="320"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="356"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="384"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="418"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="482"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="75"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDM37405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="556" mass="61191" checksum="FC1C563ADF7D2485" modified="2014-04-16" version="1">MADLKDVEAPQNTHSENKDAVAFEMDDVADQKLQNGLSEAAMDAELQQLEEQVHIIPKSRLDITMSNPAAFTYVLVAFASMGGMLSGLDQSLISGANLYLPVDLGLSAADNSLVNAGMPLGAVAGALLLSPANEYLGRRMAIIVSCILYTIGAALEAGAINFGMVFAGRFILGAGVGLEGGTVPVYVAECVPRRLRGNLVSLYQLNIALGEVLGYAVAAMFVSVEGNWRYILGSSLVFSTILFVGMLFLPESPRFLMHKGREVEAYAVWKKIRGFNDLEAKDEFLGMRQAVTAESEEQAQSKNYPWMDFFTVPRARRAMVYANIMIFLGQFTGVNAVMYYMSTLMQAIGFGDKDAVFMSLVGGGALLIGTIPAVLYMERFGRRYWANVMLPGFFIGLLLVGVGYTIDADKYPAAAQGIYFTGIVLYMGFFGSYACLTWVVPSEVFPTYLRSYGMTTADANLFLCSFIVTYNFTRMMESMQRIGLTLGFYGGIAILGWVYQIIFMPETKNKTLEEIEEIFSLPTAVIVKRNLKQTAQVIRDLSRFRLKKVFSPEPYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W6QM29</accession>
    <name>W6QM29_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S06g000457</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792020">
        <property type="protein sequence ID" value="CDM37495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QM29"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="11"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM37495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="128" mass="14360" checksum="EEB1F76167C0665B" modified="2014-04-16" version="1">MIDCERISQLSIDQDMSDLIPPHDQPTDPEEPIVGEPEDLPTHTDLEGEYVAVTNLEPHFDEETVLRNMVLGAIPPPEHSPVPSTPRRHIILPSIRVTPISADMNPRFRMKDCVQVICISGPISNNRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W6QMC2</accession>
    <name>W6QMC2_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="8">CENP-S complex, centromere protein X</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PROQFM164_S08g000059</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CENP-X/MHF2 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792022">
        <property type="protein sequence ID" value="CDM38008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QMC2"/>
    <dbReference type="OMA" id="QIQTGAM"/>
    <dbReference type="OrthoDB" id="2500381at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071821">
        <property type="term" value="C:FANCM-MHF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051382">
        <property type="term" value="P:kinetochore assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22921">
        <property type="entry name" value="HFD_CENP-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018552">
        <property type="entry name" value="CENP-X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28680">
        <property type="entry name" value="CENTROMERE PROTEIN X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28680:SF1">
        <property type="entry name" value="CENTROMERE PROTEIN X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09415">
        <property type="entry name" value="CENP-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="65"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="82"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="105"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM38008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="200" mass="21566" checksum="5D2D3DBB5E65F893" modified="2014-04-16" version="1">MPGEPPAQKRPRLPFKPPSRTNSSAPKPKGKAKQTTKASTSTTVPKTTKSKSTSIGKRPRPDSPAANANANAASESESEYDSNGSGRSRSRSLSQEPDYILAEITTANQAEDVTSSDPKIPSKLLTRLLHQNFQNEKTKVAKDANSVVAKYIDVFVREAIARAAYERAESDGNTGGRGLGDGFLEVEDLEKMAPQLTMDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W6QMK2</accession>
    <name>W6QMK2_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S02g000952</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QMK2"/>
    <dbReference type="OrthoDB" id="4359717at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM30802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="69" mass="7807" checksum="81C90EE05F102E65" modified="2014-04-16" version="1">MDAQSPTTGSRPNQKFHLGSETQGTGPQSPSDTHCHSGWSIRRLLGRRGSRNYSVLEREPNRLRKRMSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W6QMK8</accession>
    <name>W6QMK8_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 9">Chitin synthase</fullName>
            <ecNumber evidence="2 9">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">chsC</name>
        <name evidence="12" type="ORF">PROQFM164_S07g000008</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Polymerizes chitin, a structural polymer of the cell wall and septum, by transferring the sugar moiety of UDP-GlcNAc to the non-reducing end of the growing chitin polymer.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-D-glucosamine = [(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16637"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9595"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="EC" id="2.4.1.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cell membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the chitin synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="2 9"/>
    <dbReference type="EMBL" id="HG792021">
        <property type="protein sequence ID" value="CDM37660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QMK8"/>
    <dbReference type="STRING" id="1365484.W6QMK8"/>
    <dbReference type="OMA" id="WPWGNDA"/>
    <dbReference type="OrthoDB" id="26569at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04190">
        <property type="entry name" value="Chitin_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013616">
        <property type="entry name" value="Chitin_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF39">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01644">
        <property type="entry name" value="Chitin_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08407">
        <property type="entry name" value="Chitin_synth_1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="4 9" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="571"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="620"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="650"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="690"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="732"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="827"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="867"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin synthase N-terminal" evidence="11">
        <location>
            <begin position="134"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="82"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="46"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU366040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDM37660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="902" mass="101960" checksum="D95B58395F745ABA" modified="2014-04-16" version="1">MSFPQRSTSPHSPHSGDLSHSPQASETSVYGPREQAYGYEEKPENLDSQQSLLYRNQPSPFNASFDDPYASTDSLRRYTLQDPGVTIFPDGPYQESAGGLNSRRSGIQSPMSETPSEAWQNRQAPVSGLRRYATRKIKLVQGSVLSVDYPVPSAIQNAIQKEYRESEEGFPEEFTHLRYTAATCDPDEFTLRNGYNLRPAMYNRHTELLIAITYYNEDKVLTARTLHGVMQNIRDIVNLKKSEFWNKGGPAWQKIVCSLVFDGIDPCDKNTLDLLATVGIYQDGIMKRSVDGRETVAHIFEYTTQLSVTPSQQLIRPQGNESSNLPPVQMIFCLKQKNSKKINSHRWLFNGFSRILNPEVVILIDAGTKPGKKSLLALWESFYNDKNLGGSCGEIHAMLGQGWKNLMNPLVAAQNFEYKISNILDKPLESAFGYVSVLPGAFSAYRYRAIMGRPLEQYFHGDHTLSKQLGKKGIEGMNIFKKNMFLAEDRILCFELVAKAGFKWHLTYVKASKGETDVPEGAAEFISQRRRWLNGSFAASLYAMMHFGRIYKSGHNLLRLFFLHIQMTYNFMGLVMTWFSLASFWLTTTVIMDLVGTPSESNKNRGWPFGNEATPIVNNFLKYGYIFFLMLQFILALGNRPKGSRLAYTLSFMYFSIVQTYIMVLSFYLVKNAFTGGTLDFSMDRGVSHFLKSFFGSSGAGIVLIALVSTYGIYFIASFLYMDPWHMFTSSWAYFAGMTCSINILMVYAFCNWHDVSWGTKGSDKGDSLPVAETKKDDAKSNFIEEVDKPQADIDSQFESTVKRALEPYVEPEDNDEPSMDDGYKAFRTNLVLIWIFSNLILALCITSEGITRLCLTNTSTLRTSKYFAAILWTTAGLSIFRFIGSLWFLGKSGILCCVSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W6QMM4</accession>
    <name>W6QMM4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Zinc finger C2H2-type/integrase DNA-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PROQFM164_S04g000310</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QMM4"/>
    <dbReference type="STRING" id="1365484.W6QMM4"/>
    <dbReference type="OMA" id="HPTGYGP"/>
    <dbReference type="OrthoDB" id="3437960at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000125">
        <property type="entry name" value="Putative zinc finger protein 143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000512">
        <property type="entry name" value="zinc finger protein 197 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000690">
        <property type="entry name" value="Zinc finger protein 354C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003:SF20">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G10380)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR PROTEIN YY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="119"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="147"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="177"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="205"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="223"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="415"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="313"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="375"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDM35429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="440" mass="47883" checksum="32FC050E62A10C28" modified="2014-04-16" version="1">MDFTTILNRKNSAAAAAAAEAQLQQQYFQHSAQLHTGASPTMKSESGGPENPVNVYPPHGPPPMQMDGGLPDSFYYAQPTGSTPRNMAYAPAGYAGDPQMQQEPAPQGRAGIDPPPKTFHCSTCNKGFARRSDLARHERIHTGVRPHACEWPGCGKQFIQRSALTVHSRVHTGEKPHMCERCGKPFSDSSSLARHRRIHSGKRPYKCPYANCQKTFTRRTTLTRHQNHHTGTIEEAAAETEAQLRQNKDRGRPGEGMFSEHASIHSTPSPAHHPSMSPGGELPPLNMHRSAGDYYMGNGPIPPHVRGDFPQGSPRASPTATSPSLSSYGSAPHNRPSMTSHPYGLPQPLEPPANSDHRPNSVNGSPHMTSLGWASPSHGGMPSPGSANDFTYPEPTGPAYPTSMPPHMYFPNSTIRRPTSTEPENYEMKPRGDHTWSTAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W6QMQ2</accession>
    <name>W6QMQ2_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA-directed RNA polymerase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">rpc25</name>
        <name evidence="10" type="ORF">PROQFM164_S02g001017</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">DNA-dependent RNA polymerase which catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QMQ2"/>
    <dbReference type="STRING" id="1365484.W6QMQ2"/>
    <dbReference type="OMA" id="LGPTLWW"/>
    <dbReference type="OrthoDB" id="10256606at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04330">
        <property type="entry name" value="RNAP_III_Rpc25_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.120:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000221">
        <property type="entry name" value="DNA-directed RNA polymerase III subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.120">
        <property type="entry name" value="RNA polymerase Rpb7-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013238">
        <property type="entry name" value="RNA_pol_III_Rbc25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036898">
        <property type="entry name" value="RNA_pol_Rpb7-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045113">
        <property type="entry name" value="Rpb7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005576">
        <property type="entry name" value="Rpb7-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II, III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709:SF1">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08292">
        <property type="entry name" value="RNA_pol_Rbc25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03876">
        <property type="entry name" value="SHS2_Rpb7-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88798">
        <property type="entry name" value="N-terminal, heterodimerisation domain of RBP7 (RpoE)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 10" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RNA polymerase Rpb7-like N-terminal" evidence="8">
        <location>
            <begin position="8"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase III subunit Rpc25" evidence="9">
        <location>
            <begin position="83"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU369086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDM30867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="193" mass="21873" checksum="46DF938E7DE2699C" modified="2014-04-16" version="1">MFILTTISDLIQISPEDFSKFSAVALEDNINAKYANKVIQKIGLCISFYDLLESSDGLIGHGTGLVNVNVKFRMIVFRPFKGEIMLGKIASGTEHGIKIGIEFFNDILIPPQMLMEKSRFDYAEQVWIWESEGGTEFFFDVGEVVRFRVESEEWHDQIPNAPDVADETPQERRPPYSILGSMQMGGTGPITWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>W6QMT3</accession>
    <name>W6QMT3_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Beta-ketoacyl synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PROQFM164_S02g001067</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1365484.W6QMT3"/>
    <dbReference type="OMA" id="RYPWQHG"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901336">
        <property type="term" value="P:lactone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05195">
        <property type="entry name" value="enoyl_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000209">
        <property type="entry name" value="Polyketide synthase Pks12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056501">
        <property type="entry name" value="NAD-bd_HRPKS_sdrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049552">
        <property type="entry name" value="PKS_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF13">
        <property type="entry name" value="POLYKETIDE SYNTHASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23297">
        <property type="entry name" value="ACP_SdgA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13602">
        <property type="entry name" value="ADH_zinc_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23114">
        <property type="entry name" value="NAD-bd_HRPKS_sdrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21089">
        <property type="entry name" value="PKS_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="9">
        <location>
            <begin position="20"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="10">
        <location>
            <begin position="933"/>
            <end position="1255"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="8">
        <location>
            <begin position="2134"/>
            <end position="2211"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="6">
        <location>
            <begin position="933"/>
            <end position="1068"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="6">
        <location>
            <begin position="1097"/>
            <end position="1255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1284"/>
            <end position="1319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1300"/>
            <end position="1318"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="6">
        <location>
            <position position="965"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="6">
        <location>
            <position position="1162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDM30917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="2218" mass="242332" checksum="C849829E535AB77A" modified="2014-04-16" version="1">MTNMKGADSEGASYGDQGTLQPIAIIGYSCRLPGQVTSPSELWELCTRARSGWSPIPKDRFSVEAFHHPNSSKIGSFNPKGGYFLDEDIAQFDAPFFNLTVQEATAMDPQQRLLLECAYEALESAGIPKENFARRNVSVFAGGNFADYELNNDRDTETIPMHQATGCAASLQSNRISYFFDLRGPSVTVDTACSSSLVALHYAVQSLRSGESKEALVAGCHLNIVPDIWVSMSMSQLFNDEGKTFSFDERATSGFARGEGSGVVILKPLDAALRDKDPVRAVVVHSGVNQDGRTQGITLPNGQAQEELIRQVYKEANINPDECGFVEMHGTGTKAGDPIEAAAVHAALGKNRTPRNPLYIGSVKSNIGHLEGASGIIAIIKAAMMLDRELMLPNAEFKKANPNIPMSDWNMKVLTMTRPWPPRKKYLSVSNYGFGGTNAHAVLEKAPLSSKAPDRAVEDVEVDPKRKLFLISANDKESLRTRIKDFGIYFEQHPEVFEKTLFGNFAYTLGNKMSQLSYRVGVSATSLDELGIRLAQLNINPSRVLGAPIISFVFTGQGAQWAQMGVPLMHEYPVYELAIKRADQCLRDLGAEFSLVEELEKDATASDIDSPHLSQPACTALQIALVNLLESWGIRPGSVVGHSSGEISAAYAAGIYDLEGAMALAYWRGQMTSLLKSSFPSLKGTMIAIGTSRETIQPILKNLSGYATVACVNSPTSVTVSGDISTISELEKVVDNKQLFNRKLKIDVAYHSDHMKKVSKAYLAAIENIRHFSSAITPFFSSVFGRFAEPFELGPEYWIANLTSPVLFSDALGKIVADDETRPSLLIEIGPHSTMKGPIMDTLKSLGPTVSKIAYTPTILRKVNAAESILDTAAAAYVRGATLNMTAVNFPKTGAANRWFLSNLPRYPWQHGTRYWHVARIPQKHMVRDGARNDVLGVLANYSNDLEPTWRNIIRLDEVPYLRDHKMQGMVVYPLAGYLVMAIEAARRRAKQADIQISQFELREVIVGSAFVLSDETDAETTITLRPYAEGTRGSSDLWDEFRVCSWTSKRGWTEHCTGQVRVRSDPKQQAVVISSPFETQATYMKAQISRIQKPATNYLDMSHMYQVLGDLGAGYGPIFQNIDNCYSSPHHSFGDLYVRNTRSVMPKGFETPLTVHPSFLDGLLHFAWPLLGQGLGRMDLDTLYMPTVIKRMTVGLNVPTTAGEYLKGYCSGSPSLPSPEPTKFDLFATQEGSTEPIITIDGLVMTPLRDSDTNREETRKLCYKISWHPLAEAENAVEEDIQDRNGPAESHGDTYIHGDTNTNGNTKHQGNAHTNENPVKPKHDLCITYFGKSDGIADKLSIALSDESGWQVSVRNFGEVNFSQKHLVLLQTGASSLRYLTEDVFEGLKKALLNARTVLWVYRTDSPDAQMTVGLTRTLRSETSARIATLGLVPDIKYPEKPIQAAISALWPTDGTQPTKDLEFKAKGSELFVQRIVEDDSANSFIHNETHDMTISTQPFSQPGRRFKIQIGSQGSLDSLYFVDDNPLPLGDGQIELQVKANGLNFKDIVVSMGHLAQPYIGIECSGVVSSVGSNVKNFKVGQRVMAMPEGCFSTYARCAATSATEIPADMSFEVAATVPVVFCTAYYSLFDLGHLQAGERVLIHAGAGGVGQAAIMLAQMIGADIFTTIGSLDKKQFLMAQYGIPEDRIFYSRDTSFARSIRRATGDVGVDVIVNSLAGELLRETWECLAPFGRFVEIGKADITKNTRLDMQPFEHNVIFSSVDLTKVGKSKPQLMKRILGDICRLIGDGSVHPVLPLSIYRISDIEKAFRTLQIGKSMGKIVVAPHEGDQVKAVAPKTSATLLRPDASYILIGGTGGLGRSMAKWMSSKGAKNIVLVSRQAAINETVRTLIDTLAPLGVRIIVKACDVSSRESVKALINEEMKDLPPIRGVIHGAMVLRDMLFENMSLEDFSAVACNKVEGAWNLHHALINSPLDFFIALSSIAGIIGNRGQAAYSAANAFLDGFIEYRRSLGLSGTSIDLAAVSDVGYLADTDAQRRQEVMKNISCQTIDESEVLALIAAALTGDLDRSCSGQCVTGLGLDSLENNFWVQDARFSVLYEAAKGTLGNSAQCNGPSVPLHVTLSTAPSKKEALRACYEALAAKLAQVLVLSLEDMDPSITVVSLGLDSLVAIEIRNWIAREANANVQVLELLSSGSLMALAEIILNKSQAYTRTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W6QN55</accession>
    <name>W6QN55_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">ATP synthase subunit d, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">atp7</name>
        <name evidence="14" type="ORF">PROQFM164_S06g000342</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the ATPase d subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792020">
        <property type="protein sequence ID" value="CDM37381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QN55"/>
    <dbReference type="STRING" id="1365484.W6QN55"/>
    <dbReference type="OMA" id="VSKGRWA"/>
    <dbReference type="OrthoDB" id="35799at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015078">
        <property type="term" value="F:proton transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015986">
        <property type="term" value="P:proton motive force-driven ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.280.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008689">
        <property type="entry name" value="ATP_synth_F0_dsu_mt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036228">
        <property type="entry name" value="ATP_synth_F0_dsu_sf_mt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12700">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT D, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05873">
        <property type="entry name" value="Mt_ATP-synt_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005514">
        <property type="entry name" value="ATPase_F0_D_mt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161065">
        <property type="entry name" value="ATP synthase D chain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="5" id="KW-0138">CF(0)</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 12" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0813">Transport</keyword>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="100"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR005514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDM37381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="173" mass="19291" checksum="5F218D456B77B236" modified="2014-04-16" version="1">MAARSAALKIDWVKVSTSLGLRGQTATSLQAFKKRNDEARRKVQVLSEQPQTVDFSHYRGILKNQAIVDELENHFKAFKPATYDVNRQLKAIDAFEAQAVQNAEATKGKVEAELQNLQKTLENIETARPFEDLTVDEVAAAQPEIDEKTASLVSKGKWMPPGYKERFGDLSAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W6QN94</accession>
    <name>W6QN94_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Probable transposable element</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S07g000208</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792021">
        <property type="protein sequence ID" value="CDM37860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QN94"/>
    <dbReference type="STRING" id="1365484.W6QN94"/>
    <dbReference type="OMA" id="LNSTINX"/>
    <dbReference type="OrthoDB" id="4354814at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="168"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="148"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="175"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM37860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="185" mass="20406" checksum="47B27FE1C9FE08FA" modified="2014-04-16" version="1">MAGCFLAAGLIPFLPNRVLLKLNIYLRTPTPPLSRGSDSSRNFTPKTPFNSKDLRRQALSIKALLRTQSRSLISPSKRALNQLIKGCELAMHSAILLAKENKDLRDENENKKQKRARSRRQIPAEEGLSVQEASEIIARLVEALEIPLHPPGGSTQSGLEPRPRAAPRCSGCGKTGHKINRCPDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>W6QNA8</accession>
    <name>W6QNA8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="6">26S proteasome regulatory subunit rpn-8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rpn-8</name>
        <name evidence="6" type="ORF">PROQFM164_S04g000500</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M67A family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QNA8"/>
    <dbReference type="STRING" id="1365484.W6QNA8"/>
    <dbReference type="MEROPS" id="M67.973"/>
    <dbReference type="OMA" id="HAMSIKT"/>
    <dbReference type="OrthoDB" id="10256771at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08062">
        <property type="entry name" value="MPN_RPN7_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000004">
        <property type="entry name" value="26S proteasome regulatory subunit rpn-8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024969">
        <property type="entry name" value="EIF3F/CSN6-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033858">
        <property type="entry name" value="MPN_RPN7_8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540:SF7">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13012">
        <property type="entry name" value="MitMem_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0647">Proteasome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MPN" evidence="5">
        <location>
            <begin position="16"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="304"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="307"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="337"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDM35619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="352" mass="39250" checksum="6A4F70B087BE761A" modified="2014-04-16" version="1">MPATTADTLSLVNRSVTVAPLVLLSVADHYGRTAKGTKKRVVGVLLGENSGDNVRVSNSFAVPFEEDEKDPSVWFLDHNFVESMRDMFKKINAREKLVGWYHSGPKLRASDLEINELFKKYTPNPLLVIVDVQPKEVGVPTDAYFAVDEIKDDGTTTSRTFVHTPSIIEAEEAEEIGVEHLLRDIRDVAVGTLSTRITSQLQSLQGLHLRLRDIGQYLQKVLDKELPVNHAILGNLQDVFNLLPNLSTPPATQRTSGQEPQIENSELARAMSVKTNDQLMAIYISSLIRAITAFHDLIDNKIQNRQQQEESDTKRDQEANGTKGDKDAKKAGPPNAEQKEEQDSSDKNKKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W6QND7</accession>
    <name>W6QND7_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidase M20</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S07g000239</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20A family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792021">
        <property type="protein sequence ID" value="CDM37890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QND7"/>
    <dbReference type="STRING" id="1365484.W6QND7"/>
    <dbReference type="OMA" id="IWPHGRW"/>
    <dbReference type="OrthoDB" id="4676at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016813">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03884">
        <property type="entry name" value="M20_bAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010158">
        <property type="entry name" value="Amidase_Cbmase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01879">
        <property type="entry name" value="hydantase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32494:SF5">
        <property type="entry name" value="ALLANTOATE AMIDOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32494">
        <property type="entry name" value="ALLANTOATE DEIMINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="Bacterial exopeptidase dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="3">
        <location>
            <begin position="279"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM37890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="492" mass="53442" checksum="D0D26A21A717506A" modified="2014-04-16" version="1">MAHSLFLRNPPRKYLQLVKPLILNPARTLSSSRIQAMLTTELSETQVSALRANKERLANDLHHSCQWGSGIRWGDGPTDTGMQRLAISEDDKHVRDWFIRTMKDLKCNVTVDEMGNIFAVRPGRRADVPATFIGSHLDTQPTGGRYDGILGVLSGIEVIKTMNDMGLETEGGVGVVDWTNEEGARFPISMISSGVWAECIPLAQAHNLKEVPTVASLPTAASAPETMKSALQKIGYLGDVPCSYKSTPMAAHFEVHIEQGPYLVSANQRVGVVTAVQAYKWFRLNVIGRDTHTGTTAFEHRADALYAFAQMMVRAREVAASKGCLASVGIVEAKPGSVNTVPGEVSFSLDIRGPETELVAEVEKELRADFDAIAAAEGAGIGKPCRVEWTLDFDSPAIKFHEDCIKCVEQSAQAVVADASVADTKSLVRTIMSGAGHDSVFTSKRVPTSMIFIPCKDGLSHHPEEFSTADDCATGASVILQAVVRYDRKRFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W6QNI0</accession>
    <name>W6QNI0_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S12g000082</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792026">
        <property type="protein sequence ID" value="CDM38473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QNI0"/>
    <dbReference type="OrthoDB" id="4360605at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM38473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="56" mass="6310" checksum="721B0AE752BB2DB9" modified="2014-04-16" version="1">MEDQVLWHDIQAVLYQTYSELVSAATRVLSTIDNIQNPGPVPYLPDSAVMYGSWPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W6QP83</accession>
    <name>W6QP83_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidase aspartic</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S10g000044</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792024">
        <property type="protein sequence ID" value="CDM38230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QP83"/>
    <dbReference type="STRING" id="1365484.W6QP83"/>
    <dbReference type="OMA" id="YSFGMHI"/>
    <dbReference type="OrthoDB" id="4074350at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="376"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="3">
        <location>
            <begin position="1"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="340"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="406"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="344"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="408"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="434"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="454"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="464"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="478"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM38230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="496" mass="52753" checksum="516C5013A85DAE3E" modified="2014-04-16" version="1">MQLGYTNAVPINAVTSRALDSMDLGGTVMQSADLTTVLEGYQTYPGGKNYPLEVGVLSLGCPDINQTFTRDAPLPPINATFANSYLYDKGQIPSYSYGIHIGSASFGISGSLKLRGYDQGRVFGDVSAQPVDSGKFPIELIDIGIGVAKGGSPWKFSNMTGLLAQSNSSLTSGFTVAVDPANPYIYLPQSSCDAIAANLPITYNSDLGLYFWDTTDSQYTKIVTSPSYLGFTFTKNGVNTEDITIKVPFALLNLTLEAPLVTSPTQYFPCMGTDSTPALGRAFLQAAFVGVNWSKKSWFLAQAPGPDYSYIQNVVDISDSDTTITSSGNSWEPTWENSWTVLASPNSPTTNSTTSTTSTTTTTSTGSIGLSTGAKAGIGAGCGIAALAAVAAAYWFISHRQKYKRTPSQDSAAADRSSQQPPPSIITTAPVEAPDTKPSRFHELDYGRAIAFPPTSTQTSEYGQSAQQTSQSEQSAQNMSEHSQASRQGPYELSTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W6QPS5</accession>
    <name>W6QPS5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S02g001727</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QPS5"/>
    <dbReference type="OrthoDB" id="4207132at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM31577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="87" mass="9873" checksum="D60B8E366FDD3394" modified="2014-04-16" version="1">MTLASLIPRFPLSDQEAEELASFLPEIIKNFVDERRLGRGLEAWALCTATPKLFGYQIGKQDKNDLVPGEYIIYLVWEKLRGDSLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W6QPU8</accession>
    <name>W6QPU8_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Translationally-controlled tumor protein homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S02g001747</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the TCTP family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QPU8"/>
    <dbReference type="STRING" id="1365484.W6QPU8"/>
    <dbReference type="OMA" id="PYATVWA"/>
    <dbReference type="OrthoDB" id="10248936at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.10">
        <property type="entry name" value="Metal Binding Protein, Guanine Nucleotide Exchange Factor, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011323">
        <property type="entry name" value="Mss4/transl-control_tumour"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034737">
        <property type="entry name" value="TCTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018103">
        <property type="entry name" value="Translation_control_tumour_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018105">
        <property type="entry name" value="Translational_control_tumour_p"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11991">
        <property type="entry name" value="TRANSLATIONALLY CONTROLLED TUMOR PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11991:SF0">
        <property type="entry name" value="TRANSLATIONALLY-CONTROLLED TUMOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00838">
        <property type="entry name" value="TCTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01653">
        <property type="entry name" value="TCTPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01002">
        <property type="entry name" value="TCTP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51797">
        <property type="entry name" value="TCTP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TCTP" evidence="3">
        <location>
            <begin position="1"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00014759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM31597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="184" mass="20584" checksum="6211F9E9C0A9EDCA" modified="2014-04-16" version="1">MIIYTDIVSGDEIVADTFDLVPNKDFDVLWECDCRKYLKRANEDFQLEGANPSAEDADEEGGEGEATMVHDIEDQFRLVWLKAEDGAKPSKESYKTHLKPYLKKLHKNASPKFAEAADPEAAEKAWKAKAAGAMKKILANWDNYDVLMGQSTDGEAMHVLIDFREDGVTPYATVWADGLKPIKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W6QQY3</accession>
    <name>W6QQY3_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HAUS augmin-like complex subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S05g000317</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QQY3"/>
    <dbReference type="STRING" id="1365484.W6QQY3"/>
    <dbReference type="OMA" id="SNLRTWA"/>
    <dbReference type="OrthoDB" id="66964at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070652">
        <property type="term" value="C:HAUS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029327">
        <property type="entry name" value="HAUS4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14735">
        <property type="entry name" value="HAUS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM36484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="366" mass="40621" checksum="BECB66DF978E186C" modified="2014-04-16" version="1">MLPPCDPSILEHNPQFKRLYENLTTSLLNSDASTRAQSASPARTAVVEELKQCQTQNAKKRIKEQMLRQLAFAPDTNLPAECHDNLAIITLYLETPSSAIEPTTPKPETELKKPDEVLTLLAPDIEAFYANIPAFIQPLSKNISSAVQDLRALSAVNTDPATAPDADAPTTHANHIARARARDRRVRTSMAPVPLLSSQLQARVRALRHTQLSELPVARRNMAATAAEVVAARARVLERTVVTLERAKHGALARATKAKAEHLAVLAQGVEGKLEVTKLEIAATLYTPETLAALARYRQHLRQTKERLQHRRKMTIQELRDYGDVEVSDPVDIDADEGTFPDIARRYGVLAREIEEVKMEIARLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W6QR39</accession>
    <name>W6QR39_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Translation machinery-associated protein 16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S02g002163</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TMA16 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QR39"/>
    <dbReference type="STRING" id="1365484.W6QR39"/>
    <dbReference type="OMA" id="WAYIATI"/>
    <dbReference type="OrthoDB" id="270284at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.170">
        <property type="entry name" value="Translation machinery-associated protein 16-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021346">
        <property type="entry name" value="Tma16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038356">
        <property type="entry name" value="Tma16_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13349">
        <property type="entry name" value="TRANSLATION MACHINERY-ASSOCIATED PROTEIN 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13349:SF2">
        <property type="entry name" value="TRANSLATION MACHINERY-ASSOCIATED PROTEIN 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11176">
        <property type="entry name" value="Tma16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00034127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM32012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="178" mass="20743" checksum="50B7FCA8FFD9E98A" modified="2014-04-16" version="1">MPVTLTKVHKQISKKRTSTNVLHENSRDAHRLRKAGARDDRLSRHNATVNRARQPYLDRIDYIHEAIQELTEALSTEEISEFVTKYIDRDTEEIKQLESERRKGRPPSKREEALKQRVQTEAREFETGLWMPDIGDQYAMTAMKNWNGHWSGLSAIKFMRFTKDGNKLASTFPPKSMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>W6QRV8</accession>
    <name>W6QRV8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="10">NAD-dependent histone deacetylase sir2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">sir2</name>
        <name evidence="10" type="ORF">PROQFM164_S05g000637</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM164</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sirtuin family. Class I subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QRV8"/>
    <dbReference type="STRING" id="1365484.W6QRV8"/>
    <dbReference type="OMA" id="PTHEFIR"/>
    <dbReference type="OrthoDB" id="420264at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046970">
        <property type="term" value="F:histone H4K16 deacetylase activity, NAD-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="entry name" value="SIR2/SIRT2 'Small Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050134">
        <property type="entry name" value="NAD-dep_sirtuin_deacylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085:SF9">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACETYLASE SIRTUIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="9">
        <location>
            <begin position="155"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="329"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="283"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="291"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="294"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="318"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDM36804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="486" mass="53820" checksum="437DDE59641A830A" modified="2014-04-16" version="1">MDLIPAPKGETSLETTVVEVGAVDMEKQYDMEDDAPDLALEIPSDLETDSDDSDAWDTLSNCDEAIQFLRDDQIRDGLVPGACTLEEATAYRQRLHAIGKAAFVEESILRETVTAKKLCTAFGIMPPAFLDGAPDESYHSLLAVAISREFSRRPKLPQYNTIDDAVRLLRESRNIVVLTGAGISTSLGIPDFRSKDTGLYSKLAHLGLSDPQEVFDIHIFREDPNIFFSIAKDILPTEKKWSPTHAFIRLLQDKGKLLTNYTQNIDNIEANAGVLPEKIVQCHGSFARATCVKCGFNVPGDTIFDEIRAGNVPHCTACKESIAKRELKPQGLKRKRSSNGHQKDRKVSGDSSDEDDYEIPTPGVMKPDITFFGEDLPDEFGERLIHQDRELADLVIVIGTSLKVAPVAEVPGILPRHVPQIYISRTPVSHTEFDIDLLGDCDVVVSELSRRAGWDLQHHMIPADEKVDITSVEGYESRHVFQVVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W6QTS4</accession>
    <name>W6QTS4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S02g003093</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QTS4"/>
    <dbReference type="STRING" id="1365484.W6QTS4"/>
    <dbReference type="OrthoDB" id="3000060at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM32942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="186" mass="21256" checksum="0482F431F371067B" modified="2014-04-16" version="1">MLPHIPLNNNNDRSKNQRILLSIRLRLSNFSSGGQTWLTAAVPEKPVQRYAPYLHSNLYKVRRICLDGEMPYQNHLTDIIVVRSSDMIERFLYEAKRASELAKRTEASLLLLIFCHGFPNYHLLLDSSKRSRGLSIITLKGILEPGAPFTLVTTACYSRRWVITPELNSNAVTAAGTEEEFKSRYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>W6QUU2</accession>
    <name>W6QUU2_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type DNA-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PROQFM164_S03g000026</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QUU2"/>
    <dbReference type="STRING" id="1365484.W6QUU2"/>
    <dbReference type="OMA" id="QYVPPVW"/>
    <dbReference type="OrthoDB" id="5284003at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051711">
        <property type="entry name" value="Stress_Response_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47540">
        <property type="entry name" value="THIAMINE REPRESSIBLE GENES REGULATORY PROTEIN THI5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47540:SF5">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="10"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="42"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="491"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="584"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="52"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="507"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM33302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="697" mass="77723" checksum="4F3B4FA6122BAE05" modified="2014-04-16" version="1">MDLKTRLRKACDACSIRKVKCDTAGPPCRSCASLDIPCTYERPSRRRGPPNRHAEAFKKQRREPEDAVSLSPANYPSATTPLAAPFTNSQSASLPLSVESICSLHTMQMLLDDFFTYIHPLVPIPHEPSFRAAFERREDVTNHTFLALLASMIGLLVASFPRRPKLRLNTEAERTAFPNSIALVKRCLDVAIQARGTGYLDRNATVYDAAISYFLGVCAGYIYNMRRCRVYLSECRAMLQVYDLYRSPTTTNRPSSTLGPLSPLSSALLMVQDPPAHNFTESQGVDLITQELGRRLFYVTLVGYQTLHQMGSSDIKVHVPPETPTDRYPPLPLEIDDEFLFSTHVEPQPSDRVSRLVGFNANVRVYSSYTALLAWEIAFGNGQIFDWEHQRNCIWDCLKKAKSALINVPAELSLHHPKHTSPTCLSGLGGDDTIFSYSNDHIHQERRAIQYEIQKANIYASQLCTRSYLVEKYWNLFETFSKYGKSPKFMTPGSTTPDIKTEGRPNSVPSASATPTGTAPSETNTQAQHAQTDFISRMMAEERKLVIKDLFVLLRTVNEVNMEPNGASITNKIRQVASTLLGLSHRPNKSNTEIPKPTTAAAPSPSPTTVPPGLHVLTDAEAETYLHAFIETLVRLECHSSMGDAASPADGVNPQMNGRAMSYLSDYERDQEELSQWASLKEYQQKFAEAGGVLYQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W6QV27</accession>
    <name>W6QV27_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Dipeptidase</fullName>
            <ecNumber evidence="2">3.4.13.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S08g000040</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>an L-aminoacyl-L-amino acid + H2O = 2 an L-alpha-amino acid</text>
            <dbReference type="Rhea" id="RHEA:48940"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:59869"/>
            <dbReference type="ChEBI" id="CHEBI:77460"/>
            <dbReference type="EC" id="3.4.13.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.13.19" evidence="2"/>
    <dbReference type="EMBL" id="HG792022">
        <property type="protein sequence ID" value="CDM37989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QV27"/>
    <dbReference type="STRING" id="1365484.W6QV27"/>
    <dbReference type="OMA" id="CDHPRNI"/>
    <dbReference type="OrthoDB" id="445695at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070573">
        <property type="term" value="F:metallodipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01301">
        <property type="entry name" value="rDP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008257">
        <property type="entry name" value="Pept_M19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10443:SF12">
        <property type="entry name" value="DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10443">
        <property type="entry name" value="MICROSOMAL DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01244">
        <property type="entry name" value="Peptidase_M19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51365">
        <property type="entry name" value="RENAL_DIPEPTIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0224">Dipeptidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="27"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU341113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM37989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="440" mass="48720" checksum="54F11FA8093104C0" modified="2014-04-16" version="1">MSEEKSLVLESQADAPTLKQKNHPFKILWLFLSIIVATAWFTLLRSPLLPLSIEERVQKILSQTPLIDGHDDLPILVRELFHNRVNDRNFTEAFVNGKFPGHVDIPRLKQGRVGGTFWSVFVPCPKNGTDFSDENYASSVRETMEQVDIMSRVQQAYPTVFSKPPNGTTAMSAFREGKIISPLGIEGLHSIGNSLAHLRIFYELGVSYATLTHNCHNRYADAAILELPDGGIKKSDPLWHGVSEEGQKLVFEMNRLGMIVDLAHVSTETMRDVLGAGKSEWIGSRAPVIYSHSSAYSICPHPRNVPDDILELVREKNSLVMVNFAPDFISCTASDRADGIPDEDPAHATLERVADHILHIGNLIGFEHVGIGSDFDGIPTVPRGLEDVSRFPHLIKELLKRGVSDNDASKVAGGNLLRVWKKVDEVALEMQAEGALPVED</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W6QWY8</accession>
    <name>W6QWY8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Prefoldin subunit 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">YKE2</name>
        <name evidence="4" type="ORF">PROQFM164_S03g000766</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prefoldin subunit beta family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QWY8"/>
    <dbReference type="STRING" id="1365484.W6QWY8"/>
    <dbReference type="OMA" id="VQTEFAQ"/>
    <dbReference type="OrthoDB" id="248120at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051131">
        <property type="term" value="P:chaperone-mediated protein complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23161">
        <property type="entry name" value="Prefoldin_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.370:FF:000003">
        <property type="entry name" value="Prefoldin subunit 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002777">
        <property type="entry name" value="PFD_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21431">
        <property type="entry name" value="PREFOLDIN SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21431:SF0">
        <property type="entry name" value="PREFOLDIN SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01920">
        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="7"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="78"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM34042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="124" mass="13994" checksum="893063CC1B63D1DC" modified="2014-04-16" version="1">MDAQKQLQALSEEFQGLQNELEVLVDARQKLESQQQENEGVQAEFVQLDDESNIYKLIGPVLLKQEKTEATMAVNSRLEFIEKEIKRIEGEIDATQDKSEKMRSELIQLQSQVQQQAAAASASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W6QX83</accession>
    <name>W6QX83_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glutamine amidotransferase type 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S03g000886</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QX83"/>
    <dbReference type="STRING" id="1365484.W6QX83"/>
    <dbReference type="OMA" id="VERNAKW"/>
    <dbReference type="OrthoDB" id="92161at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01741">
        <property type="entry name" value="GATase1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044992">
        <property type="entry name" value="ChyE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42695">
        <property type="entry name" value="GLUTAMINE AMIDOTRANSFERASE YLR126C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42695:SF5">
        <property type="entry name" value="GLUTAMINE AMIDOTRANSFERASE YLR126C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glutamine amidotransferase" evidence="1">
        <location>
            <begin position="63"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM34162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="237" mass="26916" checksum="8107A2A05B74AFA4" modified="2014-04-16" version="1">MIPSIRIHIAVLVCDTPIQPILRKYGDYFSIFQDLLRKALKDLEISEKFKDIMVEFSEHQMVDNNRFLDLEDVDAILLTGSKHDAWADDQWIRDLTGNVRETVLKHEKPVIGICFGHQILARALGARVGRNEAGWEISSIQQMHRDIVFDVPIGCANLATSPKCEVQGLYLPNRVLSVQGHPEYNEAIMSCLLEARHENGMFDDELYNDGLSRMGDSHDGWLIAKVIARFIVDSKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2024-10-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>W6QZF4</accession>
    <name>W6QZF4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S03</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S03g001664</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QZF4"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM34937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="64" mass="7385" checksum="46376AB8187968CF" modified="2014-04-16" version="1">MWLIEALGLLPLEMQDKKLPLEFGDEKFMSADPGLELNNKTRLAAEIEILDTMARTRRQRLAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W6QZM6</accession>
    <name>W6QZM6_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Eukaryotic translation initiation factor 3 subunit J</fullName>
            <shortName evidence="5">eIF3j</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Eukaryotic translation initiation factor 3 30 kDa subunit homolog</fullName>
            <shortName evidence="5">eIF-3 30 kDa subunit homolog</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">HCR1</name>
        <name evidence="7" type="ORF">PROQFM164_S03g001749</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the eIF-3 subunit J family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM35022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QZM6"/>
    <dbReference type="STRING" id="1365484.W6QZM6"/>
    <dbReference type="OMA" id="KPHYALW"/>
    <dbReference type="OrthoDB" id="20381at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.246.60:FF:000003">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.60">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03009">
        <property type="entry name" value="eIF3j"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023194">
        <property type="entry name" value="eIF3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013906">
        <property type="entry name" value="eIF3j"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21681">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21681:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08597">
        <property type="entry name" value="eIF3_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5 7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="213"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="48"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="75"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="217"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="256"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM35022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="266" mass="29561" checksum="206E9988766CBE53" modified="2014-04-16" version="1">MPPSKWDEEEEESSAPPPIVAAPRRRFDDEEEEDVLDSWDAAEDSEVEREKAKKAAEAEAKAKAVAAANKKTKAQRIEELRLQRLREQGSGESESEDEADRRARLRATEQEADLAHAEDLFGTVDLKRNKGAPKAVVVSDSTDPTKAVDLSAMPLFKPVTKDQFARLSDTLVPLLTLHSKKPHYSLWAQDFTRKLVKDLPSAEIKKIASALTTASNEKMREERASDKGNKKSKAAKTKISLNASRDSQVDHTNYEGGDDLGDDDFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W6R3N3</accession>
    <name>W6R3N3_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycoside hydrolase, family 71</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S05g000250</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6R3N3"/>
    <dbReference type="STRING" id="1365484.W6R3N3"/>
    <dbReference type="OMA" id="RATIPFW"/>
    <dbReference type="OrthoDB" id="1046782at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051118">
        <property type="term" value="F:glucan endo-1,3-alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11577">
        <property type="entry name" value="GH71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005197">
        <property type="entry name" value="Glyco_hydro_71"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051130">
        <property type="entry name" value="Mito_struct-func_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43173">
        <property type="entry name" value="ABC1 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43173:SF33">
        <property type="entry name" value="ASCUS WALL ENDO-1,3-ALPHA-GLUCANASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03659">
        <property type="entry name" value="Glyco_hydro_71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004880349" evidence="2">
        <location>
            <begin position="24"/>
            <end position="1101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="769"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="837"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="794"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="843"/>
            <end position="853"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM36417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="1101" mass="117679" checksum="59EAB8193E5C4BAD" modified="2014-04-16" version="1">MVSLLAWATVLLLACRVQLQVQAAAVFAHFMVTNTANYTSNDWENDILLAQDAHIDAFALNMAYADSTNTGALAAAFSAADSLGFKLFFSFDYAGNGDWPKADVITLIQQYSAHSSYYFYKGQAFVSTFEGPGRADDWPEIKAVTGCFFIPSWSSLGAKPAVATGVVDGLFSWAGWPWGPQDADTYVDASYLQYLESLPYMMPVSPWFFTNLPGYKKNWMWRGDHLWHDRWQQVLYIQPEFVEIISWNDYGESHYIGPLYDQAMEAFEVGEAPFNYATEMPHDGWRATIPFWADMYKDGTAEVTEETIIAWYRLTPGAACDSGGTSGNTASQLQVEFPPAEIAQDRIFFSAVLGSFSGAVVSIGDWTQTVGWFDVPDDDVGVYYGDVAIGAHRGPVTVSLMRDNVIIATIEGKAISSTCEHGVQNWNAWVGSTSTGETVSARPTRLLSEQVCMNGTGANNFAGLCGFACRYGYCPLGACTCTRMGIGYEPPNSTGVLGYPIVGEGASYSGLCSFDCNLGFCPESACGTVEVPLSTPTVSPFLPPACVSGSGEGNLAGLCDFGCAHGFCPMNACTCTGQGALNVMDPTSETVGTAAPGVDATVYGPLCEYTCQRGYCPEGACIVAEDSDSGSGSGDGPGDGEVYIAPSIWNMPSPVVQCEPPCSLIMPPLQLASPSVISIPPWESPVEQSYLTTRTTTYDDGVVETYNGYAVATTTITISFPPSVVTEIPVWGVTINASQAQPTELEMTRSITLPYMVWSLPPFDEDPNATSMTGTVLPPPYPWSQASKDSELNTATTTWSSGSATPTADRGNPDVGVSCKPFCHLCLLCRPDWSGGGGGGSDDGSNSNSNSNSNEDECSTREAEICSTVCVAGSGCEFDCSTTTGCSVTASATSTVGTPAPAVAITLEQWPEATEEPDAEVTSIARSLDSRLSALYGDLTVLTGYEDGAATATATSTSRATTTTSAPPDLPTSLSDLQFVIFLRKPADSLDSWTWSGYLLPTYYDEEYVCNNAYEVVTSTDNIPNQTDEDSDYGYPMYLGPFAAQDLNCGYVSQGLTPGDVHCGTQVLTCLELDALHALGYPGYTCGNTEFYMQAWCPMAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W6R7M2</accession>
    <name>W6R7M2_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S07g000180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792021">
        <property type="protein sequence ID" value="CDM37832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6R7M2"/>
    <dbReference type="STRING" id="1365484.W6R7M2"/>
    <dbReference type="OMA" id="EWLIIEW"/>
    <dbReference type="OrthoDB" id="4993731at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM37832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="272" mass="31528" checksum="1EB4FA53BFBD15B9" modified="2014-04-16" version="1">MPDNRRILEWISLKDAPNGVISNSDEIFAVLQEIQKLQECTGVARGRPQELRNIEWLIIEWRGSRDKEEFCTTELYLRLEEALATRSWSREVSCLLPDRGHIIAAHPMSPPMLYEVLTIYFPVDLDPATISCLEKFSVLPRWHIDGEDPVEYPSAALKAQTPVMWKEGTCEYQGQTARRFVYFIKFVNKEGERIYKEKVRYDPGGRTPLDIMSYFFGRLEDLGMIGYEPRHVEFVEIVHYVPENYVSEPLPTQPMECPPHNIADLEGDCDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>W6R904</accession>
    <name>W6R904_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PROQFM164_S11g000010</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="HG792025">
        <property type="protein sequence ID" value="CDM38307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6R904"/>
    <dbReference type="STRING" id="1365484.W6R904"/>
    <dbReference type="OMA" id="HGRIQQP"/>
    <dbReference type="OrthoDB" id="193931at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045033">
        <property type="term" value="P:peroxisome inheritance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000011">
        <property type="term" value="P:vacuole inheritance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14076">
        <property type="entry name" value="STKc_Kin4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000042">
        <property type="entry name" value="Aurora kinase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000397">
        <property type="entry name" value="Serine/threonine-protein kinase KIN4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034674">
        <property type="entry name" value="STK_Kin4/ppk1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF110">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="180"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="499"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="55"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="70"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="133"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="153"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="544"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="645"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="696"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="775"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="798"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="814"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="858"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="923"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="939"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="975"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="998"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDM38307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="1015" mass="112093" checksum="EBCD9A7E7D044CFE" modified="2014-04-16" version="1">MSTSHQQALPLPAHAPAVSTTSSPAQKNARAPYPDMLGSPPVPPPRTSSSRRTQNETSTEKTSSSRQGKSRSDRKDTRDRTRDTTRDDRNGRSRRQPEDTSREVQSRTESEVDIPGRVKEPSAEAKSVLPSDHAMDERERPATENASTGSAEEEARGPRSRHDYNNGNVVKRKETTFGSYILGQTLGEGEFGKVKLGWKRDGTLQVAIKLIRRDTLGTNPSRLPKIYREIAILRELAHPNIVRLHEMVETDRHIGIIMEYASGGELFDYILNNRYLKDNSARRLFAQLVSGVGYLHKKGIVHRDLKLENLLLDRNRNIIITDFGFANTFDPVDPLDEEMEYNLTNKEYVKRKRLDKIGPNGLRRGDLMQTSCGSPCYAAPELVVSDSLYTGRKVDVWSCGVILYAMLAGYLPFDDDPANPDGDNINLLYKYIVTTPLTFPEYVTPHARDLLRRILVPDPRKRADLFEVARHSWLSEFSNVVSHITSSTTNVVDIANTTIPSETQKEAPPLVRSASVREPPKTHQHAPAVGGLNHHAGDVSQDPPSEKSRTPRDAKRRTVQVEYVAPQSQTTRGEPPVETSASRSRVPAPSEAQIAASAQQPTEPATAPLNLNKPLPGHLPRSASDHAAMTGSQTSGMSQGHRPATGTSMSSFGNTGRLPSRGSYGQPVAPTVTATNTEGRLAQPKSRQFALPQDPAQASSTSIRRASTQNQQLPATFNTTPRQEPPKGHKRSNTVSSLGEKLFGRSGSILGGRSQSNATRTKQDKRYPPVSMKEPLPRENSRVSVDSRRSMQYPHNRKTSESGAENRPRRFSLLPQSFSFRGFSNTRAPTPEEPSQIPRPVDPRVPQRPTSGPAGPSQGRSRATSYGTQEAMGIVDEGPGEDVHTEPGPLSYEAQIDQQFADLGSQFDYQSGSFGVPSPEEVYQNSADRIDQQNHSSKPNYYDDYNGPYDSAPRQSTQVGRSGRGPGVLQKSHRKFADAYEYERDGSHHSGSSGAARKVMDFFRRRAKSRGGDDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W6PR56</accession>
    <name>W6PR56_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Basic-leucine zipper domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PROQFM164_S01g000487</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PR56"/>
    <dbReference type="STRING" id="1365484.W6PR56"/>
    <dbReference type="OMA" id="DHEINHQ"/>
    <dbReference type="OrthoDB" id="295274at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14687">
        <property type="entry name" value="bZIP_ATF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051027">
        <property type="entry name" value="bZIP_transcription_factors"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19304">
        <property type="entry name" value="CYCLIC-AMP RESPONSE ELEMENT BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="6">
        <location>
            <begin position="14"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="104"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="106"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM26678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="177" mass="20027" checksum="A2AA47475B0390CA" modified="2014-04-16" version="1">MKSVSSASSSQSVSPRRAKHLERNRVAANKCRERKKREHKQIERRLTHETEKKDILIAQLNCLREELWDLKNLVFQHAECQDHEINHQLARMTQTVLQTHSNPDVGPSLPTGSSPTFSTGTWSDESVADNANPTGPGAYNNDWTMLPAIPTEFAPYEPNGFTDSMFENFIDTDNGFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>W6PS46</accession>
    <name>W6PS46_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Small GTPase superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PROQFM164_S01g000499</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PS46"/>
    <dbReference type="STRING" id="1365484.W6PS46"/>
    <dbReference type="OMA" id="QSTRACC"/>
    <dbReference type="OrthoDB" id="63533at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016050">
        <property type="term" value="P:vesicle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01860">
        <property type="entry name" value="Rab5_related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000464">
        <property type="entry name" value="GTP-binding protein ypt5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47978">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0636">Prenylation</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="189"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDM26690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="264" mass="29253" checksum="AC6EEE3C13AF5079" modified="2014-04-16" version="1">MASRQAAGARPGARFAQFKLVLLGESAVGKSSLVLRFVKDQFDDYRESTIGAAFLTQTISLDDSTTVKFEIWDTAGQERYKSLAPMYYRNANCAVVVYDITQASSLDKAKSWVKELQRQANENIVIALAGNKLDLVTESPDKRAIQEADAEAYAREAGLLFFETSAKSSINVKELFTAIAKKLPLDQAGPRNLRATPRPGVDLRPEAPGTQGAVRPRLTHRLRRPKATHPSIFQRWYNSVTFYDFANVIPSDSGTIPYRYGAEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W6PSM5</accession>
    <name>W6PSM5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidoglycan-binding lysin domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S01g000664</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PSM5"/>
    <dbReference type="STRING" id="1365484.W6PSM5"/>
    <dbReference type="OMA" id="CWDIIAR"/>
    <dbReference type="OrthoDB" id="5985073at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004879393" evidence="1">
        <location>
            <begin position="23"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="2">
        <location>
            <begin position="40"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM26855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="97" mass="10698" checksum="0436966BFAF17570" modified="2014-04-16" version="1">MVAIGVRSLLCILGIASLGTSAAVNTNTVQGWQLTQYCTEFYTVSNGETCWDIIARNQNRFTMSQLLCWNDDINPWCSNLIPGRQVCVAVERPGPVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W6PSN9</accession>
    <name>W6PSN9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PROQFM164_S01g000550</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM164</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PSN9"/>
    <dbReference type="STRING" id="1365484.W6PSN9"/>
    <dbReference type="OMA" id="IQIEVFR"/>
    <dbReference type="OrthoDB" id="10009520at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20353">
        <property type="entry name" value="Rcat_RBR_RNF216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16630">
        <property type="entry name" value="RING-HC_RBR_RNF216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051628">
        <property type="entry name" value="LUBAC_E3_Ligases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047546">
        <property type="entry name" value="Rcat_RBR_RNF216"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047544">
        <property type="entry name" value="RING-HC_RBR_RNF216"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22770:SF42">
        <property type="entry name" value="FINGER PROTEIN (ZIN), PUTATIVE (AFU_ORTHOLOGUE AFUA_4G03910)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22770">
        <property type="entry name" value="UBIQUITIN CONJUGATING ENZYME 7 INTERACTING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26200">
        <property type="entry name" value="Rcat_RNF216"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26191">
        <property type="entry name" value="RING-HC_RBR_RNF216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="465"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="325"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="67"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="691"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="11"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="28"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="699"/>
            <end position="709"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDM26741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="780" mass="87748" checksum="732A12B05B8378AB" modified="2014-04-16" version="1">MVLSLPVPGFSRSSTSRPADGTQSNRKSASGSETSSSSSRNARKPSLGQTGSSPHSYSITLEALRNNPFGSTSRSRGPVQFSAHETEEHKREQEELNTALETLVRIFPDVQIEVFRELLLRFDGQSRLQVCVEELLRHKKKWVSGRWNLPEGTTEAEAEGIARTVPGDENFPRQDVGNGGLVPPEERFRFDEYKAAVRMAMTREYNGLNKSTVEAVLAEVNFSYARARPTLRDLSRRTWRATFNSMFPSFRRKKDREEHPLLVWHRGVDGELVPVLKETGCSELDAELHEMLLAPLLRQRREEQHDKDFRFASELNAKEAQELNALYECECCFADVTFEQIATCSTNTHIICYHCIQRTVYEALFGQGWGKSVDLERSTLKCLAPLSIGSCEGCLHPEIVKQAIILDTAGFETYRKFEDRLSSEALMKSQLKLVRCPFCSYAEIDPVYHPSSHGVRWRFRRDGGIIPTILMTLLLLDLIPLLVIPVLILLLLDPATVTAVFGNAIRNLCLKIRPKRFTCANPSCSRTSCMTCQKSWRDPHVCHEPLLLDLRATVEAARTAAVKRTCPRCCLSFVKSSGCNKLTCVCGYSMCYLCRKALGPPVRTPAPARAFRGFDAFDGPGDIPDDTFDEQVVGNMSEDDEFEEPEGYKHFCEHFRINPGSRCTECTKCNLYQAEDEEAVARRAGEKAEREWRIRQGDSGASNPTSTAGFRNVNHDLSAGADGHSTNGRATASIWDLQLTSSTKPWAYWLSDVWADGRWKLEGQAFADWIVERVIEVDDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W6PU42</accession>
    <name>W6PU42_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Zinc finger C2H2-type/integrase DNA-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PROQFM164_S01g001070</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PU42"/>
    <dbReference type="STRING" id="1365484.W6PU42"/>
    <dbReference type="OMA" id="SHKEAHH"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001102">
        <property type="entry name" value="Transcription factor IIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050331">
        <property type="entry name" value="Zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515:SF49">
        <property type="entry name" value="GASTRULA ZINC FINGER PROTEIN XLCGF49.1-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="203"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="231"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="19"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="251"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="112"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="143"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="153"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="260"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDM27261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="271" mass="30031" checksum="17CBE011EB3EE39F" modified="2014-04-16" version="1">MDLANLLSHSTAVKPIYTPLESSYYKRSPPMSPPAEERKLPERQRLSPSLGDRHVRVQSYELPPTPPLRPGSGHAHRRASPIESLSHKEAYHHHLHRSSISSNGSIHIPRNTAPYASPAPSVSSYTSPIDAPQQPMYYPRPPTTSSFQPSTPVSAPQMPTVQTQHSHSHSSSALISPVTPAWQHHHYFPPSTSAPYQQNHDRYICRTCHKAFSRPSSLRIHSHSHTGEKPFRCTHAGCGKAFSVRSNMKRHERGCHSGRPGPPPAPTALVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W6PUE4</accession>
    <name>W6PUE4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PROQFM164_S01g001187</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM164</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the plant acyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PUE4"/>
    <dbReference type="SMR" id="W6PUE4"/>
    <dbReference type="STRING" id="1365484.W6PUE4"/>
    <dbReference type="OMA" id="YCCRSIL"/>
    <dbReference type="OrthoDB" id="21502at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051283">
        <property type="entry name" value="Sec_Metabolite_Acyltrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31896">
        <property type="entry name" value="FAMILY REGULATORY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G14730)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31896:SF69">
        <property type="entry name" value="FAMILY REGULATORY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G14730)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02458">
        <property type="entry name" value="Transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDM27376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="496" mass="55850" checksum="24F3A849A81A7811" modified="2014-04-16" version="1">MGFFSSTQPPRPATVPSDEIIPLHFWNTALCMRGTVLDISLKFDDVLDTSKLRSALEELLEMKDWRQLGARLRMNPNGRLEYHIPTRFDASRPAFAMTNAQHETSIADHPLGARIPHATSTPAIFPSPDVLSPLLRSEDAPKNIDDWICSDRPQLSIHIITFSDATLITVTWLHTLTDVMGMALILNAWTALLRGNREAVPKLQGFRLDPLTELGQRTPAEKYMHFNRVFGRKEFWWFIGLNVLDRLWYRQEERRTICIPAASLRNLCQQSSSEICASRGKEEPVPFVSESDVLLGWWVRSLYSALGLRTDQTILVNNALNLRTSLHESFTSNNSAYMGNALCMSPTFLRGHQVADEPLGQIALRIRESVTEQRTPEQVEAMTALQMQTMEQTGYLALVGDPRMMLLSCSNWHKARLFDIDFSSAVLQSSGPSSLQNPQHTGKPCYVNGVQHSANSFRNVLSVIGKDAGGNWWLTGVLRTDAWTHIEKQLHKLGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>W6PVC7</accession>
    <name>W6PVC7_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type DNA-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PROQFM164_S01g001641</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PVC7"/>
    <dbReference type="STRING" id="1365484.W6PVC7"/>
    <dbReference type="OMA" id="FSWHIFG"/>
    <dbReference type="OrthoDB" id="2283488at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF1">
        <property type="entry name" value="MISCELLANEOUS ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="15"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM27830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="597" mass="67089" checksum="D92AEAAAB9C0C239" modified="2014-04-16" version="1">MMASPVSRSRSSTRACDRCRRRKAKCDCSGESSICTNCRLARMQCTFDVPIARRGPKSKRQRSHDVAYPNVPHSPLAPALQVSEDDSITQNLGSTAPVAVPLDVWDANIPILDPALSPDTVHTAQSSISDVASTRITSALQRWHALERVIVVQSTSANLERTINHCFELFFEYLYPLTPLVHEPSLRDGLGFFVTQGRNSRADGLIYGVNSLKYPELWPDLSFTLITAVCAETAFLLPKDIFPEGERIADIFLQASRNCLATYLEADLEYPNANSVAIRYFHSNCMHAAGKPRLSWHIFGEATRLAQVMQMHEEDSLQGLTSLEVEFRRRAFWIAYIGDKSAAILNNRPITIHKYSFNSGITIGYPTGIEDETILTPGSGVPDAESTQNSFIAGFNANIRLWQSASDLLLEMRLLDSHKNGNLLPRQPPTAEESHRLDHLYVLFVTSLDDLPPFLQYDQLMSNANKDNQRLSRLTRLHIIQAANVYVSLHCLKMVITQKFEEFNYYPSAPNEMLLLRKTDIARDLLRVIRDAPFWALQINGEPCVEKIRLIGACLLEIIDQHEASPLSARARNDLSVLLDILTRLDSKASDTLRRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W6PVF3</accession>
    <name>W6PVF3_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="10 11">Cytochrome c oxidase subunit 8, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Cytochrome c oxidase polypeptide VIII</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PROQFM164_S01g001686</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of a catalytic core of 3 subunits and several supernumerary subunits. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Mitochondrion inner membrane</location>
            <topology evidence="1 11">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the cytochrome c oxidase VIIc family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PVF3"/>
    <dbReference type="STRING" id="1365484.W6PVF3"/>
    <dbReference type="OMA" id="RSKWFGA"/>
    <dbReference type="OrthoDB" id="9974841at2759"/>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045277">
        <property type="term" value="C:respiratory chain complex IV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.49.10:FF:000001">
        <property type="entry name" value="Cytochrome c oxidase subunit 7C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.49.10">
        <property type="entry name" value="Cytochrome c oxidase subunit VIIc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004202">
        <property type="entry name" value="COX7C/Cox8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036636">
        <property type="entry name" value="COX7C/Cox8_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13313:SF0">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 7C, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13313">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT VIIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02935">
        <property type="entry name" value="COX7C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81427">
        <property type="entry name" value="Mitochondrial cytochrome c oxidase subunit VIIc (aka VIIIa)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00071004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDM27875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="68" mass="7837" checksum="D35FFB09FD2D987C" modified="2014-04-16" version="1">MATSFAARRGFSTTRTQLASPYHYAEGPRSNIPFNPLTKYFFLRYWSFMIAGFGAPFAIAVWQTYKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W6PVG0</accession>
    <name>W6PVG0_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WD40/YVTN repeat-like-containing domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S01g002044</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OMA" id="QCNVWEP"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054471">
        <property type="entry name" value="GPIID_WHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF16">
        <property type="entry name" value="GPI INOSITOL-DEACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22939">
        <property type="entry name" value="WHD_GPIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="3">
        <location>
            <begin position="76"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="GPI inositol-deacylase winged helix" evidence="2">
        <location>
            <begin position="324"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM28233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="1284" mass="142832" checksum="2E54CD932A2042E6" modified="2014-04-16" version="1">MTADHRSICKFDTPADPNYAVLRNALASTVNKITAAIPELKLKQRRERIKNLKKYLKVPDILDNDLTNVCEARMHGTCGWISTKASHVKWRDGESGNDRTLWIKGNPATGKSVLAGYVIDQLKDSGQTCSYFFFKHGDKSKSNLGCCLRSLAFQMASSNSEASDAILGIQADGVCLDRVDEHTLWRILFLSGIFQATMTRHFWVIDALDECFNPPNSHHKSYTVDLDQGLSFIAPDLVQSLPISITDTESDLSLLVKNRTKALGVVGPDDRGTLAEKILDKSMGSFLWTILVLEELIRCHSRREIYQILEDVPRGMESLYKRTLDYMSQAARGKELAKNILMWAVCAIRPMTISELDGALTLDTHDSFPRLEESITTLCGELVVVDKYGRVNMVHETARQFLVSGGLESEFFVEKTQAHTDGSGVSSRRRPSARLPAARLDFAAYAYTAYSYHLSRSDPLAAGTFQLAVQFFRSNVLTWIETIADSKSLNHLIRASKHLKIYVNACAIERSPLDPRLQALRQWTTDLARIPAMFANALTISPSAIYSLVPPFSPTESMVYNTGRSGRRLEVLGTPNKQWDDRLLCIDFRQGQPRALRYGDEFLAVGLSSGTVILYHATSYQEYKVLEHGEAVKFIAFKPKTDLVATCGMKMAKVWDIRSGQVVHSLASPPSPVGMEFDGSTLLIVSRNNYVAAWFLGHGAQPESVRRPWSDTDTLETNRTPPRGTPCALALSTTHGMLAVAYSRQPIVLWDMEEDAYAGNCGKKLSSGETCTDVVVVALAFNPNPDISLLAVVYLDGDLALLDPFADRQLECFRANCQTLAPSPNGCLLAAGGANGIIHVYEFDTFKLLYRVKSSNSFIKQLAFARDSMLFADIRGAQCNVWEPETLLRETLSDDSSGTTFTTVVETVSVEAKAKITAMVVHHTSEVIFCGKDDGSVVLYEQKTATSLKTLYCHKAPVRLLVWIERRDALLSVDASNMIFLHRMQKSADKGWLSDLTVLFKSRLDSEKAIIDVLVGEMAAKFLVSTRESDHLFSLDSGKCVTERTYPQIPGIRKWLPHPESSLHIVCIDNTKVCAYSWSDWSEFSCVALSLKNDMAELKSAILYSVGQKQRIMLDLLQPNSSVDSNRITVIDLDHLVIENRDSSFLLGKQLDAVPAFDPLVTDEEGEKMVKTLSSAAPLRSRMTAFGLSVAHVIGIDESRKLVFLNRSSWVCSVDLNESGLEIAQRKDPLTIKVFEQFFVPYDWFSGKRDVVCGLAKRDIMLTRGGDLAVIRGGLDYAERVRIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W6PVT6</accession>
    <name>W6PVT6_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="6">TatD superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PROQFM164_S01g001702</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PVT6"/>
    <dbReference type="STRING" id="1365484.W6PVT6"/>
    <dbReference type="OMA" id="YGGSQKH"/>
    <dbReference type="OrthoDB" id="6079689at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008296">
        <property type="term" value="F:3'-5'-DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01310">
        <property type="entry name" value="TatD_DNAse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000072">
        <property type="entry name" value="Hydrolase, TatD family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018228">
        <property type="entry name" value="DNase_TatD-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001130">
        <property type="entry name" value="TatD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050891">
        <property type="entry name" value="TatD-type_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10060:SF15">
        <property type="entry name" value="DEOXYRIBONUCLEASE TATDN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10060">
        <property type="entry name" value="TATD FAMILY DEOXYRIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01026">
        <property type="entry name" value="TatD_DNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005902">
        <property type="entry name" value="DNase_TatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01090">
        <property type="entry name" value="TATD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR005902-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDM27891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="314" mass="34636" checksum="8C94F9C982666D51" modified="2014-04-16" version="1">MAESKPLRYVDIGINLSDPVFRGKYHGKQAHEDDLDDVIQRARDVGCSKFMVTGSDLVESKHAVHIASKYPGFCYATVGVHPCQAKLFDKYPGGPDKMLAELRTLAIEGTKAGHVVAFGEIGLDYDRLFMSAKEPQLKYFEAQLDLAVEIQLPLFLHSRAASEDFERLLAPRLAKLPKRGLVHSFTGTMDEMNRMVALGLDVGVNGCSMKTEENLEVVKAIPLDRLQIETDGPWCEIRPSHASAKHLDGAPDLPKAVKKEKWQKGCMVKGRNEPVAIARVAHVIASVKGITVEEVCEAAWNNSIRMFGLGEESP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>W6PW25</accession>
    <name>W6PW25_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">T-complex protein 1 subunit gamma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">cct3</name>
        <name evidence="11" type="ORF">PROQFM164_S01g002244</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM164</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PW25"/>
    <dbReference type="STRING" id="1365484.W6PW25"/>
    <dbReference type="OMA" id="CGGSTIR"/>
    <dbReference type="OrthoDB" id="10248520at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03337">
        <property type="entry name" value="TCP1_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000034">
        <property type="entry name" value="T-complex protein 1 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000037">
        <property type="entry name" value="T-complex protein 1 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.260.10:FF:000023">
        <property type="entry name" value="T-complex protein 1 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000005">
        <property type="entry name" value="T-complex protein 1 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012719">
        <property type="entry name" value="Chap_CCT_gamma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054827">
        <property type="entry name" value="thermosome_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02344">
        <property type="entry name" value="chap_CCT_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041082">
        <property type="entry name" value="thermosome_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDM28433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="539" mass="59115" checksum="0ABFF60565A395DC" modified="2014-04-16" version="1">MQAPVVVMNTNSGERQVGRRAQMSNITAAKTVADIIRSCLGPKAMLKMLLDPMGGIVLTNDGHAILREIEVSHPAAKSMIELSRTQDEEVGDGTTTVIILAGEMLAQAVPQLERNIHPVVIIQAFKRALADALQIVEDVSTPVDIHDDKAMYSLIQSSIGTKFVSRWSELMCGLALKAVRTVSFDVGSGKQEVDIKRYARIEKVPGGQIEDSEVIDGVMVNKDITHPKMRRRIENPRILLLDCPLEYKKGESQTNIEISKEDDWNRILQIEEEQVKHMCEAVLAFKPDVVITEKGVSDLAQHFLVKANITALRRVRKTDNNRIARATGATIVNRVDDIQESDIGTGCGLFEIEKIGDEYFTFIRKCKTPKACTILLRGPSKDILNEIERNLQDAMSVARNVIFHPRLSPGGGATEMAVSVKLSQLARSVEGVQQWPYKAIADAMEVIPRTLAQNAGASPIRVLTSLRAKHVEGHNTWGLNGESGELVDMREYGVWEPEAVKLQSIKTAVESACLLLRVDDICSAKSAQQVSGGGGGGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W6PWK6</accession>
    <name>W6PWK6_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GTP cyclohydrolase II</fullName>
            <ecNumber evidence="3">3.5.4.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">rib1</name>
        <name evidence="11" type="ORF">PROQFM164_S01g002454</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>GTP + 4 H2O = 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + formate + 2 phosphate + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:23704"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58614"/>
            <dbReference type="EC" id="3.5.4.25"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; riboflavin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GTP cyclohydrolase II family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.25" evidence="3"/>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PWK6"/>
    <dbReference type="STRING" id="1365484.W6PWK6"/>
    <dbReference type="OMA" id="RLPNVEC"/>
    <dbReference type="OrthoDB" id="5569761at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003935">
        <property type="term" value="F:GTP cyclohydrolase II activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00641">
        <property type="entry name" value="GTP_cyclohydro2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10990">
        <property type="entry name" value="GTP cyclohydrolase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032677">
        <property type="entry name" value="GTP_cyclohydro_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000926">
        <property type="entry name" value="RibA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036144">
        <property type="entry name" value="RibA-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00505">
        <property type="entry name" value="ribA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21327">
        <property type="entry name" value="GTP CYCLOHYDROLASE II-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21327:SF29">
        <property type="entry name" value="GTP CYCLOHYDROLASE-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00925">
        <property type="entry name" value="GTP_cyclohydro2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142695">
        <property type="entry name" value="RibA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0686">Riboflavin biosynthesis</keyword>
    <feature type="domain" description="GTP cyclohydrolase II" evidence="10">
        <location>
            <begin position="174"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="30"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDM28643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="375" mass="40682" checksum="DC5A9FB6CF626D6C" modified="2014-04-16" version="1">MTDLPAHASPKFDARSPPSRLDGHSDDLSQESIASGENTPTLPDSLLSPAFTPPATPGGTLNLDLNPTKILHQNQAADIHHNSQDAKGLKLLPQLPAVECIVRARIPTTNGAEMFLHLYHNDLDGKEHLAIVFGNNIRSRSLDSVRPGETEMDRMIRGAYIGKLRPGRVSSRYDEHLAGSSTPKQVEPPLVRIHSECYTGETAWSARCDCGEQLDEAARLMSFPVEDLASDAPPEVQSLSSHSTGGVIVYLRQEGRGIGLGEKLKAYNLQDLGSDTVEANLLLRHPADARSYGLATAILEDLGCGADAIPEGIRLLTNNPDKVRAIEGPNHEVLVKERVPMIPLAWRTGGQKGIKSSEIEGYLKTKISKMGHMIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W6PX25</accession>
    <name>W6PX25_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PROQFM164_S01g000328</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PX25"/>
    <dbReference type="STRING" id="1365484.W6PX25"/>
    <dbReference type="OMA" id="LMNVAPF"/>
    <dbReference type="OrthoDB" id="5215911at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF50">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G00430)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="149"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="309"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="353"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="398"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="425"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="462"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="492"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="52"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="249"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="252"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM26519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="538" mass="59541" checksum="07B7145D01AEFEA5" modified="2014-04-16" version="1">MESDSIQDETIWAPGTVRLEDKPVHQSRDQLVLFPTPSADPNDPLNWSTARKALNFTLVSFFVLWTFVQLDIGFTAWGPMQDELNFSVDLLNANAAVNYGGLAIGCIFFMPLVHKYGRRPIYIFSVALQLASSIWQAEMYTIGDLMGSGLISGIGGAISEIVVQITIADMFFVHQHATMNGWYVVVQCAGAFLGPVASGYIVVAQGWRWMWWWCVIFFGVTLLCVVFLFEESKYVPYLDGREFTADVQVTDEPSKSRKDRDAADAKSANETIASPVHTNPDIPMKTYFQRMALVTITNEALWPHFYQPIVALFTFPAVSYAAITYGSMLSWFAIMTSLQASYMIIPPYNFDAIGVGLMNVAPFVGALLGFPFGGHLSDKSILWLSKRNGGIYEPEMRLWLALPLAIIGPAGILMFGLGLAYGVHWALLAVGFGFFGFTLASISGITLSYLMDCYQDIISDALVGVIFMRNIFSVVVLFALTPWVEGMGLRDLHILLAFIALVVLLIPVPLLVWGKKARIATAASYRKMAANQLSHRTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>W6PXM9</accession>
    <name>W6PXM9_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PROQFM164_S01g000523</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PXM9"/>
    <dbReference type="STRING" id="1365484.W6PXM9"/>
    <dbReference type="OMA" id="WQQDVRV"/>
    <dbReference type="OrthoDB" id="6058203at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd01446">
        <property type="entry name" value="DSP_MapKP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18533">
        <property type="entry name" value="PTP_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000142">
        <property type="entry name" value="Protein tyrosine phosphatase (Pyp1), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050348">
        <property type="entry name" value="Protein-Tyr_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134:SF561">
        <property type="entry name" value="PROTEIN TYROSINE PHOSPHATASE 36E, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134">
        <property type="entry name" value="RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="6">
        <location>
            <begin position="189"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="4">
        <location>
            <begin position="443"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="5">
        <location>
            <begin position="612"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="109"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="27"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="60"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="109"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="126"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM26714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="736" mass="81429" checksum="0718F885D563058B" modified="2014-04-16" version="1">MTGPGRSPSSPWVQSAQGGHHDGGVAQSIQSTMSPPTTGMMSSTAFTEKSSPNYFGMAVQNPNNQQTSNPGLSMQNNWGTLPHTQPLPSPQLPVFSQESVSAGLKNLLKTEPETSRIRRESALHGSSSPQTTSWSKSSSSHPLGNFSFAQPSELRLPAGKNLAPTPQGFTPASFPWVSAERCAERLESSQSNTMLFDVRPFAHFRQANIKGSLNLCIPTTLLKRRSFDTQKLEGTFTDDADKQNFARWRKCDVIIIYDSAAAELKDAAPLLNLLNKFQAEGWKGDGLILQNGFRGFSGRFPHLIQQPQTQTTGSSSKRPSPMRINLQSVAPVVGGCALPESSSAVNPFFGNIRQNMDLLGGVGQIPLKQPDQLTEAKRQQLPSWLRGASDTKDQGHIVSNKFLVLEKTELERMKQALTYEGPSGDTNGSPKKYRVAGIEKGTKNRYNDIYPFDHSRVRLEGIPAGACDYVNANHISAELTNRKYIATQAPVPDTFDDFWRVVWEQDVRVLVSLTAEVERGQVKCHRYWESGKYGPFEVKAYSEKHIYIEPRVGSPMPSTERPDGTNENPVITVRNFSICHTSFPFEPLRDITQLQYPYWPDFGTTSQPTHLLRLIEQCNKVIRATSNPSFSSEQAEPKGQRPVLVHCSAGCGRTGTFCTVDSVLDMLKRQRAQAAGGGGLDQNPSGSSEWMGDFTLDLIAKTVEDFRRQRPSMVQNLSQYALCYESVLEWLASEMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W6PXP3</accession>
    <name>W6PXP3_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Spindle assembly checkpoint component MAD1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PROQFM164_S01g002367</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MAD1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PXP3"/>
    <dbReference type="STRING" id="1365484.W6PXP3"/>
    <dbReference type="OMA" id="YKLDFMP"/>
    <dbReference type="OrthoDB" id="331602at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051315">
        <property type="term" value="P:attachment of mitotic spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000074">
        <property type="entry name" value="Spindle assembly checkpoint component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.457.60:FF:000005">
        <property type="entry name" value="Spindle assembly checkpoint component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.457.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008672">
        <property type="entry name" value="Mad1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23168:SF0">
        <property type="entry name" value="MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23168">
        <property type="entry name" value="MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD1 MITOTIC ARREST DEFICIENT-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05557">
        <property type="entry name" value="MAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="440"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="29"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="565"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="440"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDM28556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="714" mass="81781" checksum="D04AE2AC6CC2F9AC" modified="2014-04-16" version="1">MRRSTTMRQSGRFTQSQAQSHQLIHDAEKDELRVQLSTLKYELENIKQERELEALRHEKEIRDLQLKADADFRKAQTAESSSNRATHKSDELAKELKEIQDQALNDKLAFERKIRGLQDDNQNLQEEFDDTQARLSDQERQFKYQINELETVRASLQKTIEEFQTDIQNARTSQESTQEKLSQREAEVAELEAENIRLKAEGNDAEVLAVLKRELSEQVHHIRELESANRDQTTELRHLRKVSKNVEVVEEQKRSVENQLQLMKGIEAELNTVQIQKQILEDERQSWVSLLQENEQPAEFDSPDAIVRAVVQGRIEIATLLDRLGTVDAQFLEKDEAIKSLENDKNNLQRELEKLRVAGAASAGGPVAAESRLRARLERQRALAVKEVEYLRAQLKTFDAEEATMNEDQSQFDEQKSEQITQLQQLVDEYRSELHKVHEELSKQEATPKEEARGVKRALSPTNSEAESERIAVLSRKNRKLQEHLTKSDQATTLARRELDAAKSQIKSLKAKSRTRILELRDNPTAQTEQIKMTTLATLQSANRDLMAQLRGGRTDVKFVPVSTVESIKLEMQDMERIVADKEKRMRRLKEIWTAKSSEFREAVASLLGFKLDFLPNGRVRVTSMFHLSSAYRHGDCDAPSDSGPGSMGNGEENSIVFDGENGTMKISGGPNSLFAMELKPLIKFWVEERKDIPCFLAAMTLDFYDKTTRAARM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W6PY61</accession>
    <name>W6PY61_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Small ribosomal subunit protein mS29</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PROQFM164_S01g002731</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mS29 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PY61"/>
    <dbReference type="STRING" id="1365484.W6PY61"/>
    <dbReference type="OMA" id="GLAHWMT"/>
    <dbReference type="OrthoDB" id="274828at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019368">
        <property type="entry name" value="Ribosomal_mS29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12810">
        <property type="entry name" value="MITOCHONDRIAL 28S RIBOSOMAL PROTEIN S29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12810:SF0">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10236">
        <property type="entry name" value="DAP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="48"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM28920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="502" mass="55177" checksum="F15A194DD0CA0AB7" modified="2014-04-16" version="1">MASSWCWNCLSRLRPTPRALLPPSATPRISSASFHSTAVHYALPAKKKGASLTSMKHRQSTSLRRKKKKVADRGGRPPAVGERKALRKRIVLSNPNALEIEGMLELSPETMVDSRLRGTVLGLPVPMIDQLRAVQAFKPKQGWSIFRRPGTVLRRDTIEMGRLFEQISGDADEAQKGKVVKKIVTGMKGSGKTVHLLQAMAMGFLKKWAVITIPDARDLVSGEFAYAAIEDSNPLKYVQPTATSALLTRTVDANRELLASLKVSQKHPSLKMLKPSSTLEDLAKLGFTDPAVAWRVFQALWTELTATAPAAGLEKDFQPRPPMLVTVDGLAHWMTESAYRSAEHKPIHAHDLIFVHHFLSLLKEGESLKNGGLLLYATSCSNNPNPEGLKIALDRLAARQAGISASSPEFPQLPAYSDADPRVVDFFHPAEKAVSPLELQTLGGLTRDEARGFMEYFARSGLLREIINDQWVSEKWSLSGGGIIGELEKFGRRVRATASVSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W6PY89</accession>
    <name>W6PY89_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase S64, Ssy5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g003045</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PY89"/>
    <dbReference type="OMA" id="WVVKLGR"/>
    <dbReference type="OrthoDB" id="5424209at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM29233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="622" mass="69005" checksum="C6B07FFB8C39092D" modified="2014-04-16" version="1">MDPSVPSLGPSGLPTPPLSPRKRRRHLRESDDAEGDMSLEQYLQRVEVYRSTSIPSRFPSPVKLEVLPSLEKVLRPLYPEVSSILNQHNLPGMMMYRCWRMTKPGYPRGDIPVDIFSVLLDTSTPNISPLGPIKDEILSLFRRHKVRVHVEISNDKLCHHPTFFSIALNHPLVKAYDRVMQNLVAILKQTLGSNFNMLCPFNVGPNEAKAQPTIVVFVEPWTITNWFELRLQVMSRLLPHIQADSFDIEFLPGAMSFLNGGGIPFTHNVKEHEVPRMGSSIGIEGDKNAGTLGGFVTLTHGDVVRRGFLTNYHVVRPSPSQRPSDSNDFLQSLDRFGSSPVRPLANKITMESPSGLDKDATAAHISERLEAMREHETELNAKVQERELLGATPNPGILEALSNTKDSIQEALLLRSVVDRMPFSLGDVQFVSGYEVHGGHVIDWAFVQMSKAAEPKFFRPNFMPSVPKKYQPEKWSPSQNSAIWLGKKPLSEFGSLKDGDWCCKKGRTSGFTAGVVNGPKAYCKWNGPEVRYTPSGQKVEMRALETQEFVIVGKRAGVNEESFCTDGDSGSFVLGESGEVKGLLWGGMEKDKWNLGLASSMPDVMASIQEKMGGSVTLSLPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W6PYZ4</accession>
    <name>W6PYZ4_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fucose-specific lectin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S01g002767</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the fungal fucose-specific lectin family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PYZ4"/>
    <dbReference type="STRING" id="1365484.W6PYZ4"/>
    <dbReference type="OMA" id="VFNIRLY"/>
    <dbReference type="OrthoDB" id="407298at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.70">
        <property type="entry name" value="Fucose-specific lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012475">
        <property type="entry name" value="Fungal_lectin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07938">
        <property type="entry name" value="Fungal_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89372">
        <property type="entry name" value="Fucose-specific lectin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0430">Lectin</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM28956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="306" mass="34170" checksum="3B76065D23CA23A4" modified="2014-04-16" version="1">MPSNEAHEIVFRTSIAACNSGSDLRVYMQDVLGKIRESKYDDKWSNGTEKNIVASAKPYSPLACTSSDLENIRVYYLSTENTINDVTYDKSKGWYEGSLGKKCFITAPCSKLAACHLNGPDVTNRVYCQMANNTIQEYGLKDNGNWETMSNLGSAMPGTDITCTVFKTSEPNIRVYFQHMEHGIIEKCYDSKRGWYGGGAKLPKVQPRTSIACTSHMTSSETVGIRVFYNTSNTMCEMVYDGKSWTEGHFHADCIPGTQIDCISWMNGPRPEVRVYFQAGHEISAITEYVWTQGRWSSGKLALPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W6PZU4</accession>
    <name>W6PZU4_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Cysteine synthase 1</fullName>
            <ecNumber evidence="5">2.5.1.47</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">O-acetylserine (thiol)-lyase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">O-acetylserine sulfhydrylase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">O-succinylserine sulfhydrylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">cysB</name>
        <name evidence="20" type="ORF">PROQFM164_S01g003586</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the conversion of O-succinyl-L-serine into cysteine, the last step in the cysteine biosynthesis pathway. Can also use O-acetyl-L-serine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>O-acetyl-L-serine + hydrogen sulfide = L-cysteine + acetate</text>
            <dbReference type="Rhea" id="RHEA:14829"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:58340"/>
            <dbReference type="EC" id="2.5.1.47"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>O-succinyl-L-serine + hydrogen sulfide = L-cysteine + succinate</text>
            <dbReference type="Rhea" id="RHEA:53816"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:136856"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-cysteine biosynthesis; L-cysteine from L-serine: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cysteine synthase/cystathionine beta-synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.47" evidence="5"/>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PZU4"/>
    <dbReference type="STRING" id="1365484.W6PZU4"/>
    <dbReference type="OMA" id="VVTVFWD"/>
    <dbReference type="OrthoDB" id="10259545at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004124">
        <property type="term" value="F:cysteine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01561">
        <property type="entry name" value="CBS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000011">
        <property type="entry name" value="Cysteine synthase (o-acetylserine)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050214">
        <property type="entry name" value="Cys_Synth/Cystath_Beta-Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001216">
        <property type="entry name" value="P-phosphate_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007989">
        <property type="entry name" value="PRK10717.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10314">
        <property type="entry name" value="CYSTATHIONINE BETA-SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00901">
        <property type="entry name" value="CYS_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="19">
        <location>
            <begin position="39"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023192"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00047931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00050981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00058228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00072087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00078262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00079147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00081847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CDM29773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="372" mass="39817" checksum="F1DACD65C5EADA50" modified="2014-04-16" version="1">MFRQSVRRFATTAARAAGEGSTAYCTRVSTAQGVVNGLTEAIGNTPLIRLKKLSEQTGCNVLGKAEFQNPGGSVKDRAALFVVKDAEEKGLLQPGGTVVEGTAGNTGIGLAHVCRSKGYKLVIYMPNTQSQGKIDLLRLLGAEVYPVPAVAFDNPQNYNHQARRHAESLDNAVWTNQFDNIANRQAHIDTTGPEIWAQTEGKIDAFTCATGTGGTLAGTTRYLKTISDGRVKSFLADPPGSVLHSYIQSGGTLIDRSGSSITEGIGQGRVTDNLQPDIGLLDGSVSISDEKTIEMVYRCLDEEGLYLGASSAMNVVAAKEIAEKLGKGNTVVTILCDGAYRYADRLFSSTWLESKNLRGSIPKHLEKYIVLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q0K9</accession>
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        <submittedName>
            <fullName evidence="5">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
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        <name evidence="5" type="ORF">PROQFM164_S01g003313</name>
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    <organism evidence="5 6">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028942">
        <property type="entry name" value="WHIM1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42107:SF1">
        <property type="entry name" value="WHIM1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42107">
        <property type="entry name" value="YALI0D24453P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15612">
        <property type="entry name" value="WHIM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="169"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="24"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="354"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
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            <end position="561"/>
        </location>
    </feature>
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        <location>
            <begin position="577"/>
            <end position="597"/>
        </location>
    </feature>
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        <location>
            <begin position="28"/>
            <end position="45"/>
        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
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        </location>
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        <location>
            <begin position="580"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF15612"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="597" mass="66496" checksum="5E040F709AC062DD" modified="2014-04-16" version="1">MDPKTCRTCRRDGSIARNLLLPSTYPITSTMPSDSELSSLSSAPPTDDEATMAIDHPTGIAKYFKKESETPPPKREPSPPHEYVVADNPDIAFIVAFRARFHEVFPKGVPHYGPQDIEKGIEESPPGEYIERLLCALLGLVLNRKKEVERNHFTRPLEEAIHTHQAQWPKEWEGKNPLHGGGSFATMSPVERLRLLRTLILWSLSSSEAVQAKIKESYKQARHDDDLNQPLSVQPWGRDSLKRRYWLIEGHDDTNFRLYRESNPALKNNTWWSIAGSIPELEAVVEKLEGEKGTNSKKLSERIRASIPRFEASEEKRRRREYRLARKAAFVRPDPGFSMYEGRTRGKKLKYTYSDDDDIFSDDDEPSARRSTRNAAPTEASTESRRPRFTASGRQIRSRAGGLYGEALLIGQRNGADDDEFDEDDEEEVIRPQRARTSTHPNGYSGYDADDLEDASEVPSSANESGNEWQGVEDDLEHDVEGDNEEDEASADESSGNEEPESLVVQLRYGKGDAPSNLEVQIKKSPPAKEVEIAEETAAASSAQAPPKTLHQSNSDAQQAPTMIATSHPFASIPQVPTHSAAAVAAPSVSSNGVDQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q0N3</accession>
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        <submittedName>
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    </protein>
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            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q0N3"/>
    <dbReference type="STRING" id="1365484.W6Q0N3"/>
    <dbReference type="OMA" id="EKPAIFW"/>
    <dbReference type="OrthoDB" id="2093409at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22903">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR38488">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR38488:SF1">
        <property type="entry name" value="OXIDOREDUCTASE 9.5 KDA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G08980)-RELATED"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0830">Ubiquinone</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM29526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="76" mass="8313" checksum="5FA58B15271DA4A0" modified="2014-04-16" version="1">MSAPLFWSTPLRYIRWAAHEKPAILAALCIGVMGPISLATIPPIRHALGDVDPEPIPLTYPIPQGPRVIPKGYDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2024-10-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q0P1</accession>
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            <fullName evidence="1">Genomic scaffold, ProqFM164S01</fullName>
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    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
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                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
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        <source>
            <dbReference type="EMBL" id="CDM29850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="51" mass="5958" checksum="8964881E2E4F4903" modified="2014-04-16" version="1">MMWEWLVHLYAPNATVMAEPREYLKIFLGRKTGRYSPTPLIYASSLLEIAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q149</accession>
    <name>W6Q149_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF2293 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S02g000189</name>
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    <organism evidence="3 4">
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            <taxon>Penicillium</taxon>
        </lineage>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
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                <person name="Malagnac F."/>
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                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30040.1"/>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q149"/>
    <dbReference type="STRING" id="1365484.W6Q149"/>
    <dbReference type="OMA" id="RSVICFE"/>
    <dbReference type="OrthoDB" id="5288828at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018744">
        <property type="entry name" value="DUF2293"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38113">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38113:SF1">
        <property type="entry name" value="DUF2293 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10056">
        <property type="entry name" value="DUF2293"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2293" evidence="2">
        <location>
            <begin position="158"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="359"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="501"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="580"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="743"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="793"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="873"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="590"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="613"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="747"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="793"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="835"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="888"/>
            <end position="900"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM30040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="933" mass="105467" checksum="C671824A80462BB9" modified="2014-04-16" version="1">MTRVIRRAGSVRHGPDRATQRRARRHKVIMESVTQEKKKLRSVICFEAQAPSGYTFIPAGNPQLTTTCKERCRDEGLQIYAVSTTPHHRHHNLSQHVHRIGYHFPSTVVAAVCSELGFYLTSTGKTVPSTFPIQKLENNIRGESEISQQTLNTEARDALKDLFPNMPEKDLNQIIKTAFQKGQKKVGTATELPLARRAQLAVVAHVRHVYTDYDRLLKTTSFHEARGVVEHTTLAKVIEWRGDDENGQTVLEDVFREVIVISDDEDSESEEDAVASAGHQDTSVEILASDTRAHEIRCQPMDNTNSLGQDLPRELSEEAPPGFRFVTRAPATDTINRRGFNRYKAWTRAVKEYREGIQGTEEPRFSGAPAEKQSPRYAEQRITKEVPAARRQDIVPQHAEVHRRVAPGSASNDNQAHPVLAIPLMDRQRHVGIQENYLHSDVQQNYSTYDMNARPTGLTNKESPELQILEELSGPRNVIMSHSQDVPPSRMEPIFRQERLPPQSDRTNAPVFVSGPKENRQKLTPVGRYPDSVNTPLLRPGSNTQDSILPSIENPRPIESRWTDASHPLVHMTNKMSLRSVTPGYSQGEMGHHPDAIEKEGDSEHASKRRRLTCRERSRTESRPDPWSARPMGLPVSEGFAPHPYRRLELVQDHRPKELPHFRRDYLPVEQPPVVGYQRERNQNSLSYSNAQYGLETRSVLGRQHISGPYEPKAQAGLSSTSIVVSEGDRTFRAAPAVSNSGPWHPYHGDRSFRSDRAPKEPRAMRHTRIDSGRPLSENVHTDRNLYAEDFVRHVDHREPPPLEYVSRRAGPEATPIGEPSQSTRIRDFDYLGTKNLSQVSSDQRGSLPKGPRVTPSHDHLRTFSDSIIGKLQPHVSPHERPASGGFNSLRPSSNYPSSSQTTEQDRPVYVQRVEPRPPYPLPDGRHFVIVDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q150</accession>
    <name>W6Q150_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S01g001755</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 25 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q150"/>
    <dbReference type="OMA" id="CGNGYLR"/>
    <dbReference type="OrthoDB" id="47375at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06532">
        <property type="entry name" value="Glyco_transf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050757">
        <property type="entry name" value="Collagen_mod_GT25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002654">
        <property type="entry name" value="Glyco_trans_25"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10730:SF53">
        <property type="entry name" value="GLYCOSYLTRANSFERASE 25 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10730">
        <property type="entry name" value="PROCOLLAGEN-LYSINE,2-OXOGLUTARATE 5-DIOXYGENASE/GLYCOSYLTRANSFERASE 25 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM27944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="387" mass="43563" checksum="9F686194BF676EFE" modified="2014-04-16" version="1">MVFSAFRLRFVQLLLVAFGVAFILFNLRESIHGADAPTQQVWSNYHDWDNFDAIGNETLGFQKVFAINLVSRPDKRDNIVLGSSVSNFHVDWIDGVTPGEIDAKSYPYNWDHGHKPTEYAARRAHINGLQRIVQERLASAIIMEDDADWDVSIKVQLQSFAHAVRTLQLQLRHNRKVPTQSPYGDDWDILWLGHCGVSCKTDLPFYLTPNDPTIPMPHRFLPLWRDPPVFEGHERPDHSRLTCTANDAACSMFYAVSYRGAQRILAALSVNPSGLAEEIDIGAQFDVSLGRMCGNGFLRCFAPYPSITGGFHQAGSRAKSSDIHEETGDGEGFFSWGVKYSTMLNINRILKGERTVHATWDDVDVLDVIPEEITMEKGAVYVPQPRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q182</accession>
    <name>W6Q182_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">DHX35</name>
        <name evidence="10" type="ORF">PROQFM164_S02g000229</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q182"/>
    <dbReference type="STRING" id="1365484.W6Q182"/>
    <dbReference type="OMA" id="FHEVMET"/>
    <dbReference type="OrthoDB" id="10253254at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000020">
        <property type="entry name" value="ATP dependent RNA helicase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001075">
        <property type="entry name" value="ATP dependent RNA helicase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000007">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF136">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX35-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="32"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="9">
        <location>
            <begin position="234"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDM30080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="672" mass="75143" checksum="844EC1E1260C7C45" modified="2014-04-16" version="1">MASEQELSTSFIPALYKPAALLPIARHKKNLLYLVEKYPVTIVVGQTGSGKTTQLPQYLDQAGWCEDGKIIAVTQPRRVAATTVATRVAEEMRCKVGEEVGYSIRFEDLTSPATRIKFLTDGMLLREALVDPLLSRYSVIMVDEAHERSLSTDVLLGTLKKIRKKRPELRIIVSSATLQAEDFLRFFAGDEYRPEAEPADLGGSIGRIISLEGRMYPVDMLFLESPAEDYIERAVKTVFDIHTQEPEGDVLLFLTGREEIDTAIQLISERAATLHPKAPSLLPLPLYAGLTTEQQMYVFEPTPENTRKVIVSTNIAEASVTIDGIVYVIDSGFAKLRAYNPNTGIDTLTAVPISKASATQRAGRAGRTKPGKCFRLYTQQAFEQMPEATVPEIQRSNLAPVIMQLKALGIDNIVRFDFLTPPPAELIIRALELLSSLGAIDDYAKLTKPLGVRMAEIALDPMMAKVLLTAPSFNCLSEILTIAAMVNLQGTVWVQHAGDKRSAESHRRKFAVEEGDHLTYLNVYQAFVTKGKKDSKWCRDNLLNYRALLRAVSIRGQLKRYLERFGIQVDETLSSRQGTADLSKQPEQIRRCLTTGYFAHAAKMQPDGTFKTVSGGLTLHAHPTSLMFNRKADWVIFHEIMQTGDKTYIRDVTKIEKSYLLEYAPDYYRVRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q184</accession>
    <name>W6Q184_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S02g000442</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q184"/>
    <dbReference type="OrthoDB" id="5329176at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM30293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="76" mass="8420" checksum="DC7CB3805707EAE2" modified="2014-04-16" version="1">MIIISAVELNVAVTAANVPSFKAIWRKHVNGTLKGNTNSVNLSEERTLWREQCEDSDYLPQQRARGESGSAGFLDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2024-10-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q1J7</accession>
    <name>W6Q1J7_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S01g003639</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q1J7"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM29826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="50" mass="5741" checksum="41067DF5DBBB64A2" modified="2014-04-16" version="1">MCTFYFADNMFDKDSLACVDVFFPSTVLVHALFSMGARSHLVRILFHLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q201</accession>
    <name>W6Q201_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DUF676 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PROQFM164_S01g002045</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the putative lipase ROG1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q201"/>
    <dbReference type="STRING" id="1365484.W6Q201"/>
    <dbReference type="OMA" id="EKSCATH"/>
    <dbReference type="OrthoDB" id="4349937at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007751">
        <property type="entry name" value="DUF676_lipase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052374">
        <property type="entry name" value="SERAC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48182">
        <property type="entry name" value="PROTEIN SERAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48182:SF2">
        <property type="entry name" value="PROTEIN SERAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05057">
        <property type="entry name" value="DUF676"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF676" evidence="9">
        <location>
            <begin position="71"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="15"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDM28234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="250" mass="27894" checksum="B35010D6FDFBC51F" modified="2014-04-16" version="1">MFFRKQRHAKPELYPDSPSSSRDSTKSSRSLFSLSKALPRTSNTSDGQAESVKGPLGLSLLYSPTAPEIDFIFVHGLGGNSRKTWTKSSLRYNFWPREWLSKDPAFKNVRIHSYGYDSYYLKGKEDCLNIHHISKSFLGAISTSPCILNSGTHIVVIGHSKGGLVIKKAYILAKQDEVYKALAGRFAAFYFLATPHRGADSAKILKNLLKVAYDRAYVGDLEPNSGAVQVINDGFRHFSAGLELWSFYET</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q263</accession>
    <name>W6Q263_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">(DL)-glycerol-3-phosphatase 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">HOR2</name>
        <name evidence="1" type="ORF">PROQFM164_S02g000544</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q263"/>
    <dbReference type="STRING" id="1365484.W6Q263"/>
    <dbReference type="OMA" id="QVHTFDG"/>
    <dbReference type="OrthoDB" id="40579at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050308">
        <property type="term" value="F:sugar-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07527">
        <property type="entry name" value="HAD_ScGPP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051806">
        <property type="entry name" value="HAD-like_SPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43481">
        <property type="entry name" value="FRUCTOSE-1-PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43481:SF4">
        <property type="entry name" value="GLYCEROL-1-PHOSPHATE PHOSPHOHYDROLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01135">
        <property type="entry name" value="C1.5.6:_HAD__Beta-PGM__Phospha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM30395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="237" mass="25574" checksum="5BBE1FC187DD2F80" modified="2014-04-16" version="1">MSSATGTFSAPAQVHTFDGLLSDFDGTIVDSTDAIVKHWHKFGNDLGVDPKIILATSHGRRSIDVMGIYDPTKANWDYINEVEGRIPKEYGSDAVEIPGGRDLLAALETSGARWGVVTSGTRPLVHGWLEVLGLPHPKNLVTAMDVPLGKPDPRCYLLGREQLEIEHSTSIVVLEDAPSGILAGKAAGFKVIALKTTHSLEQLQEAGADWIVEDLRSISVKGVVDGQVQIEIKNAYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q2R3</accession>
    <name>W6Q2R3_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Proteinase inhibitor I78</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S02g000410</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q2R3"/>
    <dbReference type="STRING" id="1365484.W6Q2R3"/>
    <dbReference type="OMA" id="AMTMDHR"/>
    <dbReference type="OrthoDB" id="10013825at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.10.10">
        <property type="entry name" value="Trypsin Inhibitor V, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021719">
        <property type="entry name" value="Prot_inh_I78"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39600">
        <property type="entry name" value="PEPTIDASE INHIBITOR I78 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39600:SF1">
        <property type="entry name" value="PEPTIDASE INHIBITOR I78 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11720">
        <property type="entry name" value="Inhibitor_I78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM30261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="79" mass="8694" checksum="4E05245BA6552643" modified="2014-04-16" version="1">MPLVVPGINSSFGDKSEWVNKLMGKTISDTTNETSFAKKDLPESHRVLKPGDAKTMDHNPNRLNILVDDAGEVHDVNYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q2Y3</accession>
    <name>W6Q2Y3_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 15">Transketolase</fullName>
            <ecNumber evidence="4 15">2.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PROQFM164_S01g002380</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 15">
            <text>D-sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = aldehydo-D-ribose 5-phosphate + D-xylulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:10508"/>
            <dbReference type="ChEBI" id="CHEBI:57483"/>
            <dbReference type="ChEBI" id="CHEBI:57737"/>
            <dbReference type="ChEBI" id="CHEBI:58273"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="2.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="15">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <cofactor evidence="15">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="15">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <text evidence="15">Binds 1 Mg(2+) ion per subunit. Can also utilize other divalent metal cations, such as Ca(2+), Mn(2+) and Co(2+).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="13">Binds 1 Mg(2+) ion per subunit. Can also utilize other divalent metal cations, such as Ca(2+), Mn(2+) and Co(2+).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
        <text evidence="12">Binds 1 thiamine pyrophosphate per subunit. During the reaction, the substrate forms a covalent intermediate with the cofactor.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 15">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the transketolase family.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.1" evidence="4 15"/>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q2Y3"/>
    <dbReference type="STRING" id="1365484.W6Q2Y3"/>
    <dbReference type="OMA" id="ADYMRGS"/>
    <dbReference type="OrthoDB" id="10267175at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004802">
        <property type="term" value="F:transketolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07033">
        <property type="entry name" value="TPP_PYR_DXS_TK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02012">
        <property type="entry name" value="TPP_TK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.920:FF:000003">
        <property type="entry name" value="Transketolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000003">
        <property type="entry name" value="Transketolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000004">
        <property type="entry name" value="Transketolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055152">
        <property type="entry name" value="Transketolase-like_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005478">
        <property type="entry name" value="Transketolase_bac-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020826">
        <property type="entry name" value="Transketolase_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049557">
        <property type="entry name" value="Transketolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033247">
        <property type="entry name" value="Transketolase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005474">
        <property type="entry name" value="Transketolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00232">
        <property type="entry name" value="tktlase_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43522">
        <property type="entry name" value="TRANSKETOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43522:SF2">
        <property type="entry name" value="TRANSKETOLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22613">
        <property type="entry name" value="Transketolase_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00456">
        <property type="entry name" value="Transketolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="TK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00801">
        <property type="entry name" value="TRANSKETOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00802">
        <property type="entry name" value="TRANSKETOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0106">Calcium</keyword>
    <keyword evidence="7 13 15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 13 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12 15" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="5 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Transketolase-like pyrimidine-binding" evidence="16">
        <location>
            <begin position="355"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="417"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="116"/>
            <end position="118"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="358"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="385"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="443"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="467"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="475"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="479"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="526"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="14">
        <location>
            <position position="29"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="14">
        <location>
            <position position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR605478-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR605478-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR605478-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR605478-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR605478-5"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU004996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CDM28569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="683" mass="74428" checksum="06D25B4D1978EC3A" modified="2014-04-16" version="1">MGYTDLDHLAVNTIRLLAVDAVAKANSGHPGAPMGMAPVAHVLWNMMNFNPKNPEWPNRDRFVLSNGHGCMLQYALLHLFGYKISLDDLKNFRQLDSITPGHPEAHDTPGIEVTTGPLGQGFANAVGLAMAQAHSGGVFNKPGFELFNNYTYMFFGDGCAMEGIASEAASMAGHLKLGNLIAIYDDNHISIDGDTKCAFTEDVMKRFEAYGWHTEWVKDGDHDLEGIEAAIRRCQQVTDKPSVIKLTTTIGFGSKLAGTGGVHGNPLKAEDAKHVKALFGFNPEESFVVPQQVYDQYHKHAAEGAAKEQGWNQLFQKYQAEHKTEGADLARRLSGKLPEGWEKKLPVYKPTDAAIASRKLSEACLEAIHDVLPELVSGSADLTGSNNTRWKNAVDFQPPDLGIGEWAGRYVRYGVREHAMAAVMNGLAAYGTIIPAGGTFLNFVSYAAGALRLSALSRVRVIHVATHDSIGLGEDGPTHQPIETLAHFRAMPNCMVWRPADGNETSAAYYSAITSKHTPTVMALTRQNLPQLELSSLENALKGGYVAVDTPNAAVTIVSTGSEVSIAIEAATYLQEKHGVAARVVSIPCFEVFDSQTKEYRLQVLPDGIPVLSVEACCTMGWERYSHEQFGLNRFGASGPYKEVYAKFEFTPEGISKRALATIDFYKGVPVRSPINRAFQQIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q362</accession>
    <name>W6Q362_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Extradiol ring-cleavage dioxygenase, class III enzyme, subunit B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PROQFM164_S02g000565</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DODA-type extradiol aromatic ring-opening dioxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q362"/>
    <dbReference type="STRING" id="1365484.W6Q362"/>
    <dbReference type="OMA" id="HAVYVPM"/>
    <dbReference type="OrthoDB" id="7396853at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016702">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07363">
        <property type="entry name" value="45_DOPA_Dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.830.10">
        <property type="entry name" value="LigB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014436">
        <property type="entry name" value="Extradiol_dOase_DODA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004183">
        <property type="entry name" value="Xdiol_dOase_suB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30096">
        <property type="entry name" value="4,5-DOPA DIOXYGENASE EXTRADIOL-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30096:SF0">
        <property type="entry name" value="4,5-DOPA DIOXYGENASE EXTRADIOL-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02900">
        <property type="entry name" value="LigB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006157">
        <property type="entry name" value="Doxgns_DODA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53213">
        <property type="entry name" value="LigB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Extradiol ring-cleavage dioxygenase class III enzyme subunit B" evidence="6">
        <location>
            <begin position="18"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM30416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="279" mass="30859" checksum="BA08199B4DB1F862" modified="2014-04-16" version="1">MSVSDVPCAPSLFISHGTGPFPLLDPEQESYRQLLRRHGSKLDGVKGILLFSAHWETETPHISGGDNPGIFYDYEDMRDRLPPAAFEFQYPAPGNAKLATEVANRLKECGFSPTLDLQRGFDHAVYVPMILLRPQADIPIVQMSILKGHDEQDSTEKNIKLGQAVECFRNAGYAIVGSGGSYHDFEAIAKAFFTNEPVPAGTERFENFLKNAASIPDSSQREVALLGWRELPASHTAHLTNCSEHLMPFMVAAGSGGDIAGVRFDMYEYKGAPMSFYRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q3B4</accession>
    <name>W6Q3B4_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Vacuolar calcium ion transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PROQFM164_S02g001238</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Has a role in promoting intracellular calcium ion sequestration via the exchange of calcium ions for hydrogen ions across the vacuolar membrane. Involved also in manganese ion homeostasis via its uptake into the vacuole.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Vacuole membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q3B4"/>
    <dbReference type="STRING" id="1365484.W6Q3B4"/>
    <dbReference type="OMA" id="IGWCIAE"/>
    <dbReference type="OrthoDB" id="1699231at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015369">
        <property type="term" value="F:calcium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004713">
        <property type="entry name" value="CaH_exchang"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004798">
        <property type="entry name" value="CAX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00378">
        <property type="entry name" value="cax"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503">
        <property type="entry name" value="VACUOLAR CALCIUM ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503:SF22">
        <property type="entry name" value="VACUOLAR CALCIUM ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0050">Antiport</keyword>
    <keyword evidence="6 10" id="KW-0106">Calcium</keyword>
    <keyword evidence="4 10" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="8 10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <keyword evidence="10" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="123"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="159"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="253"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="286"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="320"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="349"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="377"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="11">
        <location>
            <begin position="63"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="11">
        <location>
            <begin position="253"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDM31088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="397" mass="43060" checksum="EECCEE9C54CEA043" modified="2014-04-16" version="1">MVSRRDTQPAPSHHRQDPWIHIQRFFKMPSQNGLKELSINHGRPAMVLLPLAGLAKIFHWNPIIVLTVNILAIIFLSEAISTSSDELTAHLGELQGALLSATLGNTVELTAGILALIHDEIPFAQSVMVGSILSDILLVFGCCLVTASYNKEVLEFNSALAKTLSSLMMITAVTMLLPTALYSTFPVSEIDDRVLSFSRGTSLVLLALYGGYLYFYLGTHKHLFLSIESEASDDENNVVSSSAANKASLASSIIRLTTAVAATVFCTELLLESVDDMAKTLGVSEVFIAIVFIPIASNSTEGVTVIAASRTGDTDSAIRVIIDSLLQIGLFVIPFLVVIGWCIAEPMTLFFDSFQTVTMFLAILVVNHLLRDGQYAYIHGAMLIALYSSLVVAFYAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q464</accession>
    <name>W6Q464_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Heterokaryon incompatibility Het-C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S02g001290</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q464"/>
    <dbReference type="STRING" id="1365484.W6Q464"/>
    <dbReference type="OMA" id="AFIKGHK"/>
    <dbReference type="OrthoDB" id="2506204at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010816">
        <property type="entry name" value="Het-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052577">
        <property type="entry name" value="VWA7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14905">
        <property type="entry name" value="NG37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14905:SF7">
        <property type="entry name" value="VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07217">
        <property type="entry name" value="Het-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004879352" evidence="2">
        <location>
            <begin position="23"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="330"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="570"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="673"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="345"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="371"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="606"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="680"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="704"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="736"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="763"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="775"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="786"/>
            <end position="798"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM31140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="798" mass="87063" checksum="2127B669B74F48C7" modified="2014-04-16" version="1">MPLLHVGSALLVLLLILPQVHAFGAGNIASISAVEGKNWRHGDIEDVLKTLAFISGHKWTSTMIKRVYFGNWLRDYSQAMDVGTLKNLQADTIRVLVWVLSFLSFGYATAEFEVTAERLGVYRPEEHIDNPKDYADNEDARQYDKRLRPPVRAIELEIDPNTGMKNYIANERGDWATSAAFIKFSLSRSIHYGRTYTNGGHKKGNEEDLCEALRCLGQGLHTLEDFAAHTNYVELALREMGFNNVFPHTGTATQINLQGHHVFPLVTGTFGMVDFFHSVMGEANDHFTQSEVNEMDIALGDAAANAQSNNSLNALTGLLGKIPGTKDLVSEAESLKRSSEAQEMANRSRSATTGYAQSSNSHERSRAGPTGDSSKPSSGLNAMPDFNPQETVAKIYPILAFRDKVMRSLNAIIEKIPGLESLVEKISETLTVVVMSLLAPFIRPLIKAASNSIQTGSAGVIDASGKHQYEPWTDPHCTDPTHSLLSKDHFANILNEPAGRVASSIVEYVAPRVLYAWQHTDVPESEVLNDCMQVFHHPALRNMHIDAHRVMFETVEKWVHSRSDRGASLNSVLSSEGVRSGRNTGGVSHTHSDGHSAFAALGGASHGQSQSHNQSSNNGGNSSGGFSSFFPQQNQQQSNSSSSGMPWDKLSSIPGLSGLSKFESKISNFLPGGLSRDANDQGTQQTQNSYQGYQVGGGHEAMQPSPQQYENYHQPQHVPQHSQGYQHNQHQEQHYGGSQNHPSYVQQDGHLGHPQSHNSHNAPPYGSHPGSHPGPHGGFGQGQGHGHGHGHGHGHPGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q4P0</accession>
    <name>W6Q4P0_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S02g001758</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q4P0"/>
    <dbReference type="OrthoDB" id="5429770at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM31608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="136" mass="14966" checksum="39AD960A471353B0" modified="2014-04-16" version="1">MPLTAPPSWGYKTVKINARSARHLMHEVHPEVMKPLENSSLWGTGLHQQRIIADGLFVKVKFGGILYKYKQIIDVVHVRSSWCLCDGVKREAVVVEASGARSSICGEKRMFNTAANPTAASAVIKGEFRVFIQGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q4S3</accession>
    <name>W6Q4S3_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">D-serine dehydratase</fullName>
            <ecNumber evidence="11">4.3.1.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">D-serine deaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PROQFM164_S02g001121</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the conversion of D-serine to pyruvate and ammonia. May play a role in D-serine detoxification.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>D-serine = pyruvate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:13977"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:35247"/>
            <dbReference type="EC" id="4.3.1.18"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:13978"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DSD1 family.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.18" evidence="11"/>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q4S3"/>
    <dbReference type="STRING" id="1365484.W6Q4S3"/>
    <dbReference type="OMA" id="WPRFYGW"/>
    <dbReference type="OrthoDB" id="20198at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008721">
        <property type="term" value="F:D-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036088">
        <property type="term" value="P:D-serine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009636">
        <property type="term" value="P:response to toxic substance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.10:FF:000016">
        <property type="entry name" value="D-serine dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="entry name" value="Alanine racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.20">
        <property type="entry name" value="D-serine dehydratase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001608">
        <property type="entry name" value="Ala_racemase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051466">
        <property type="entry name" value="D-amino_acid_metab_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026956">
        <property type="entry name" value="D-ser_dehydrat-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042208">
        <property type="entry name" value="D-ser_dehydrat-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28004:SF2">
        <property type="entry name" value="D-SERINE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28004">
        <property type="entry name" value="ZGC:162816-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01168">
        <property type="entry name" value="Ala_racemase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14031">
        <property type="entry name" value="D-ser_dehydrat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01119">
        <property type="entry name" value="D-ser_dehydrat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="PLP-binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0216">Detoxification</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="D-serine dehydratase-like" evidence="14">
        <location>
            <begin position="282"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00051198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00055764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00066349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00069616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00075219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CDM30971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="410" mass="44798" checksum="BCA13E29E433BF7E" modified="2014-04-16" version="1">MDYSLQNHASYIGRPVSELPTPALVLSKSVLERNTQILLDDVKRLGIEFRPHVKTLKCIEVTRMMLGNGTHRRIVASTLAEIRGALGLVKEGILDECLYGLPISASALPFLETITKSLKIILMVDSEQQIDLLESYAAKSSSPVAPWPVFIKIDVGSQRAGMVTDSPSLPRLIQRIESSSAATVYGFYCHAGHSYACRTEDDAAAVLQTEVEGVVEAAKVLVDGKSDRRIVVSVGSTPTAHVVKRLQGALPEGMELELHAGNYPTNDLQQVATSLVEPTQQAVRILADVCSVYPDRNEALINAGTIALSKETSEFPGFAVVVDRPQWSVVRMAQEHGILGWAESDQTRRLVAKTGSKSGDGEKVEAAFAVGDKVLLYIQHACITAAMHYAYYVVDDEDIVRETWVPWKGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q513</accession>
    <name>W6Q513_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PROQFM164_S01g003071</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q513"/>
    <dbReference type="OMA" id="PMWFFLN"/>
    <dbReference type="OrthoDB" id="2428527at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17476">
        <property type="entry name" value="MFS_Amf1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000294">
        <property type="entry name" value="MFS transporter of unkown specificity"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718:SF41">
        <property type="entry name" value="MFS TRANSPORTER OF UNKOWN SPECIFICITY (AFU_ORTHOLOGUE AFUA_5G09940)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="156"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="227"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="258"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="297"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="329"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="359"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="385"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="423"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="465"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="29"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM29259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="503" mass="54441" checksum="6A2397234B758B90" modified="2014-04-16" version="1">MGADSINLKPVESARSLASTFSPIHEVFFVAIVCMGQFMTQTNVGVCLSPLDTVGDSFGIDDPGILSWFMAGYSLTVGTFILVSGRCGDLFGYRRMFIIGFCWIALWSLVAGVSVYSNYILFIFARVFQGIGGALLMPNALAILGATYPQGKRKNMIFAIFGAAAPNSALLGAVFGAIFSQLAWWPWAYWTQAIVALCCAAVGLLVIPSIHHDAKFEKSFLGLLKALDALGGVCGIGGLVLVNVAWNQAPIVGWSEPYVYVLLIVGILLLAAFFYVEFRVSENPLIPFHAFSPDVSFVLGCVACGWGSFGIWIYYFWRFEEKFRQLTPLLTSAQFVPVGPVGIMACVVTGWLMGRMRPALIMVLSMTAFTVGNVLIAIAPVHQTYWGLTFVCLLVTPWGMDMSFPAATLMLSNAVERKHQGVAASLVTTIVNYSISLSLGFAGTVEVHVNNGGYTPSDVLKGYRGALYLAVGLGGLGMFLSMIYAFKGHRTERQPVEAKNEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q5P3</accession>
    <name>W6Q5P3_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S02g001436</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q5P3"/>
    <dbReference type="OrthoDB" id="5350472at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM31286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="198" mass="21873" checksum="63AD01CFB4CE71EA" modified="2014-04-16" version="1">MTRLSSLRQTNSGRELGIEFSTLSRLDYATPISPDCANPSNSRQETSDNNTSLDLLLGLLNKFFLGASLGGCVHKDRLVGSWRLPVKRARYWLVGGEHITLSGWSFSKRPELYQTIGNCAETYPIVHLLRGLNTTNGNVHGLALRKKALRAPRYKHTLSGRFWNAVANPCKNCQFLIELHGGNLQNFCRFAGSAGAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q5T9</accession>
    <name>W6Q5T9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Major facilitator superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PROQFM164_S02g001491</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q5T9"/>
    <dbReference type="STRING" id="1365484.W6Q5T9"/>
    <dbReference type="OMA" id="GMMTLFM"/>
    <dbReference type="OrthoDB" id="3639251at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000065">
        <property type="entry name" value="Putative MFS pantothenate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF64">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="120"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="187"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="259"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="304"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="331"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="364"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="396"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="430"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="28"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="480"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="485"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDM31341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="505" mass="56786" checksum="884A49584F3CF78D" modified="2014-04-16" version="1">MFRRKASTNVDFRSPEEKALVRRLDMFLMTFGCLSQVIKYLDQQNINNAYVSGMKEDLNLLGNELNLFTTYFNVAYCIMLIPSQVILTYVRPSYWLPGLEIAWGVLTGLVAMTTSAKQVYIIRVFLGLCESSAWPGMMTLFMHWYTPTELAKRMGFYHSCQAVGQMLSGAMQAAITDTLDGHSGLAGWRWLFVINAIITVIWGFAGFVMLPDLPNRPNPRAFWFKKVHGELSLERLARNGRAEPKKMTWAGVKRTFSGWVVYFIAILYIATVLGTYGYVYFGLFLKSLKNPDGSARWTVSQVNAIPIGGSAINVVFVWIWALLSDYFETRWALIVIQAVIGIVPCIIMSIWTTHPLSVGLSAVYASYFISYICLGTAPLIFAWLSDLIPQDPEARSLVVGVAVAGYYAISSWSQVLVWPASQAPFYKYGWQSALALLVLVIIMTSILRFVDVRYLLPKREEFRAVLEEDIVVGKGVSTSVSPDQIEGRHRRDESPKVATSNVHEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q683</accession>
    <name>W6Q683_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S02g002374</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q683"/>
    <dbReference type="STRING" id="1365484.W6Q683"/>
    <dbReference type="OMA" id="KAVLYFW"/>
    <dbReference type="OrthoDB" id="4526936at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004879608" evidence="2">
        <location>
            <begin position="18"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="625"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="698"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="698"/>
            <end position="715"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM32223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="761" mass="73637" checksum="43B095CAC155961D" modified="2014-04-16" version="1">MRSSLVMLAGLASSALAYPTDRAVEARNLDLLGELLGDLTLDVTGILSTVLEGTSVEIFAGLSAQGAAALSGGALGCKAGAIHAKAKAALKVWLRLHAEIDTTLKTSLIAWCDGHDELVLSADVLAALSVYIPGSANIAAKGQLYVTIDGIFEAASLESALVLSVAAQTSLSAWVEAKVDLDVDIKVGLNVCAAGGIVGSLSADIKASLLAWLNSTECELSADLKVSVLAWINGRAGGELVEIGALADTALSTVSVGASVGIHVLESGLLSVGGQASLAAFLGVDLAVALGADVKLALEACAKGELATAVELDVRTKLAIWLASSDCSLGVELKAVVLLWLSFAVEADVSVALNLVDGVLGDVTGLLTDIVDDLSVDLRGALSLCAAGGSLLDLTFSARTELAAFLSGCTSLNIDVSIQIIIIEWFTGCSIPGAPAATASSSVLSLPSSTPYLASTSSVPSGASASVGLTVSASVPAASGSVSVPSGSDATSTPCATETSEIVSSTVIPNPSGSGSLTASIPAIATGTVPAVVPTGASPTGTTVSGSVPAGSATTGTATTVVIPGSSGSSATTVTIPVTVTGTAPSGSATTIVVPNPSGTSSLTVTIPAQATGVSPTGTTVVGGSVPSGSAPSASTTTVVIPGSSGSSSTTITVTVPAEATSTAPSGSATTIVVPHPSGTGSLTVTVPAQATGTAATTGASGVTASAPAPTSPATIPSGGSTGSNVTETVTVTATLPSGGNTGSGKATETVTVTATVCGCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q7H8</accession>
    <name>W6Q7H8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S02g002102</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q7H8"/>
    <dbReference type="STRING" id="1365484.W6Q7H8"/>
    <dbReference type="OMA" id="CFAFHLE"/>
    <dbReference type="OrthoDB" id="7464126at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004879969" evidence="2">
        <location>
            <begin position="22"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="239"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="324"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM31951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="975" mass="110806" checksum="9B39BB1323DB4CEE" modified="2014-04-16" version="1">MMFSMILSILFLLSLLPFVKADDDWDDFTNNLATDLAPLITLFGERLTKQFLSESISTLDNVIFALSPLGVLTAVVSVIRVCGSSSLRAFVGRAQEGPAEAESELLPCVSESTAEVFNDGGITRVFGRPKIVEIVAWEDVDKITGEKETKIGTLRDALEEKAWSCNSKVSPTDLPELDMPNLSLNKGIKRRDQFWFHCAAILGGILQTGTVVFATLTVFVYPQHFQKNDKAVAPYAFPLYIIGTTLLFLGMFFCAFIMERSSKEFYLKAEKPSKIYWLQPGNQDVGDQVFNAFLAVNEGPESSMTDKLRYTKSIRDRRFDRKYLETYSTLISTILGFICQFVGLRGLHSSVTLAQLGSTFLMAIIRTCLRTERMKPDENKMKDDRELTSHKQQEIDCFVFYLEKVESFELASIPDRPPNMPSQRFTPHLGTPLAKQLIHTRTQLARLTTSSRQSLGVDWNGMPIRRIASNLAETIESTMDLMSSWGVNLGKTFEFRLGFKCKGPSPGSVTEAPGTYSIGLIRSGDALQWKLDVAELEAVLGLWTWSLYKSDENWQNSTLCRLIGLSEDEAKKDETFLYFYKWIFRQTEARLVPSEGYDNSSRLFSFEPKSLPYDGKVLAVRTDNELEAMVAQDIYIQFLKEVFLNLDDLGGDVDVIPELQNSFLASSTRIDDLIRCFENSKLGSREDALLCIVPVLRYRHLLPDLAADSTKVRARRERLIEKGDWKGAFTLVRWICQRSDDSQFERSVHELGFLCRRALSDSNKDVRKIGFEQTCELLTSDIRAEFLQVHNHVPPLQQSVSDDRIEWWNSFSRQLGWIAWNLSANVPGMEYCKPILRSLNVTEDLQGSNDQNQDPDKIEGAIHALKDWLTLYKLDDIDREGDGEDEQACLEWLVRNNFHALLYFLLLRWVELYEDLPMLVRMGYSFAARIRSQRALDILRRQGADIDMIDPNNCSAQPKHYSATLGDQSTCNCCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q7V9</accession>
    <name>W6Q7V9_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Inclusion body clearance protein IML2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Inclusion body clearance protein iml2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">iml2</name>
        <name evidence="7" type="ORF">PROQFM164_S02g000478</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Inclusion body (IB) resident protein that interacts strongly with lipid droplet (LD) proteins. Involved in LD-mediated IB clearing after protein folding stress, probably by enabling access to the IBs of an LD-stored soluble sterol derivative that acts as a chaperone in inclusion clearing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Interacts with lipid droplet proteins.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q7V9"/>
    <dbReference type="OMA" id="AFHSDIY"/>
    <dbReference type="OrthoDB" id="2154985at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019412">
        <property type="entry name" value="IML2/TPR_39"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31859">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 39 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31859:SF1">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 39C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10300">
        <property type="entry name" value="Iml2-TPR_39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="270"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="310"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00043897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM30329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="707" mass="79475" checksum="A27159411ED24668" modified="2014-04-16" version="1">MLRVGSWLYGKKPAQSVDSKVELKDLHDALTAATLILNDDVDGAESGLSTGTSSFHNLGKGVVAFVRATLGFEQEIMRQASERLYEAETSAANDQTRSQQNAQAPNAFHSDIYAAGTEYALCQAIAQLMSAVVGVLNESLTESIKAFYRLRKAYIALDAIMKMEEKFMEQRDIRKVLRPTASDLSSSSAACPDTKSESSSLLSKKSAKMANIEKSELNSSMNSLAISSRAVSPDVSTPSTLAKHIHQDPDSDIFKNEIDVFVHSGSNFCFGILLLLISMVPPAFSKLLSIIGFHGDKQRGLRMLWQASKFHNLIGAMAALALLGYYNGFVRYCDIMPDPTPGGSDVEGYPQERLAALLAEMRFRFPNSQLWLLEESRMLGANKKLDSALEVLSTDKKSPLKQVEGLCVFEKSLNALFLHRYNVCAEAFIECVELNTWSRSLYYYIAGSCHVVLYRQSLDDPKLAAEHAKKATMYMRKAPEFAGKKRFMARQLPFDIFVTRKIAKWEARAKEWNVSLVDAIGVDPVEEMIFFWNGHSRMTNEQLQESLTRLEWCESEKNKMWSREGSEEKAILELLRAAVFRSLYRHEEAKKILLTCVLNHEKSVFKGHLKDDWVHPVAHFEMAANLWMQRPTYQALHGITSPEASEEASAESRETNIEIERKQVSECKGYLDFAARWESYELDARIGLKVTAAMEAINKWQSIHAEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q7W0</accession>
    <name>W6Q7W0_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PWWP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S02g002631</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q7W0"/>
    <dbReference type="STRING" id="1365484.W6Q7W0"/>
    <dbReference type="OMA" id="WPVIVCD"/>
    <dbReference type="OrthoDB" id="62853at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026093">
        <property type="entry name" value="MGARP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000313">
        <property type="entry name" value="PWWP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22910">
        <property type="entry name" value="PROTEIN MGARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22910:SF6">
        <property type="entry name" value="PROTEIN MGARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00855">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00293">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50812">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PWWP" evidence="2">
        <location>
            <begin position="130"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="478"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="75"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="346"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="368"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="483"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="512"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM32480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="562" mass="61694" checksum="37C7562E7F24A4BC" modified="2014-04-16" version="1">MADDTPVSAPQGEQPERATEQPTDSENKSEDVTLSEDKPAETEAAPDKKTDAEAEPDKPASSDEAPEAKADGEAAEAAPADVEAIAPAEANGTPASAKKSSKNRRTSTGTTQKLSRKKSQSRITHLDAKPGQTYLARLRSYAPWPAIICDEGILPSSLLETRPVTAMQKDGSYKGEYGDNGRRAHERTFPVMFFDTNEFAWVPNTNLTPLDPTECKNISEKNKTKSLINAYKVASEGHNLQYFKKLLNDHQAAIDQEEAELEAQEAEKEAAKAAKEAKKGKRKSKGAETDVEMEDADDSKKSKAPSKKRKKDAETDAEAEKSNTKLKLTTPKAPTEDTGKKTPASKTKKAPAKKAKAAPVASDEGDSADAKESEKPIDPEELRKKKEKEILFLRHKLQKGFISRDQPPKEDEMASMAGYFDKLEKHSDLEVSIIRSTKINKVLKMIVKLNSIPRDEEFNFRHRAMGILSSWKNILDADTPGPADKDEKSAVNGAKEDGVETPKLETEEEKELESKSTKDVDSPMPDADEKAPEPEKEEKPEEKAAEEPTEEKSEEKPAEAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q9P1</accession>
    <name>W6Q9P1_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chalcone isomerase, subgroup</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S03g000077</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q9P1"/>
    <dbReference type="STRING" id="1365484.W6Q9P1"/>
    <dbReference type="OMA" id="FMHLRDG"/>
    <dbReference type="OrthoDB" id="18193at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016872">
        <property type="term" value="F:intramolecular lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016087">
        <property type="entry name" value="Chalcone_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016088">
        <property type="entry name" value="Chalcone_isomerase_3-sand"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036298">
        <property type="entry name" value="Chalcone_isomerase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47284">
        <property type="entry name" value="FATTY-ACID-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47284:SF3">
        <property type="entry name" value="FATTY-ACID-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16035">
        <property type="entry name" value="Chalcone_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54626">
        <property type="entry name" value="Chalcone isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="65"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="Chalcone isomerase" evidence="3">
        <location>
            <begin position="175"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="24"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM33353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="417" mass="45155" checksum="8312FB3ED6E5F54F" modified="2014-04-16" version="1">MASTLRQNPWRTYQCLTRQQIRTTRLSSRHLSTTPLRSNATNNPLRSRASAAADLQHASQAQRKMVLSAAGMIVCAVGLYGVIKLDLFGLNELDTSKDDKTISTPPKNGAMRMDGPVGFTSGGPSLITIQGQDRLEQVPTGTSTIPHFPSTIRLPTSEATEGKQEGDDLAPSQGEEYQLLGLGVRTVSFLSIEVYVVGLYVAKSDITELQRRLLHTAIHPLTTDSDAAISGVGTTAATSLVSPERQQLKELLLDADRGDAAWSAIIKENGIRTAFRIVPTRNTDFMHLRDGWVRGITARAKAKKTAGPSEFQDESFGTSMNDFKAVFGAGKGKSVPKGQTLVLMRDAHGALDALFQPGTDKPVKWMGRVADERISRLVWLNYLAGKTVSSEGARTSIVDGLMSIVERPLGTVVQKVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2024-10-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q9V4</accession>
    <name>W6Q9V4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S02g001109</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q9V4"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM30959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="65" mass="6926" checksum="1CEB196A34B96D9B" modified="2014-04-16" version="1">MSVLRDKGLLEGREAETLELADTMEDSFQGSKVAPVEVRGKGMCPGVLLSPEVSLIGQRSTIVHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W6QAT0</accession>
    <name>W6QAT0_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g000626</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QAT0"/>
    <dbReference type="OMA" id="KQNYAHD"/>
    <dbReference type="OrthoDB" id="3438340at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021641">
        <property type="entry name" value="DUF3245"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11595">
        <property type="entry name" value="DUF3245"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="104"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM26817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="213" mass="22853" checksum="6BE374F85FFF4E0A" modified="2014-04-16" version="1">MSLSKSESDVILNRANIALSRSQRLVASWLPQQTPEELANPKTDEELQREEDEIFTAVPETLGVGAPLPQKAADGSWNRTELDSNDKLRKQLLGKNYDRVMKAAAEQKAANAASTAAAASASASVSKADVEDEYDEEDGRSAMLARQKNKRKGGAGAGRGVHPAAAAAEARDKGGEEGEGEVVPAPARSKGRKKATSYLDELLAERAKKRKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W6QAT5</accession>
    <name>W6QAT5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="4">tRNA-splicing endonuclease subunit Sen15</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S03g000502</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QAT5"/>
    <dbReference type="STRING" id="1365484.W6QAT5"/>
    <dbReference type="OMA" id="HPDDQIA"/>
    <dbReference type="OrthoDB" id="10002170at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000214">
        <property type="term" value="C:tRNA-intron endonuclease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000213">
        <property type="term" value="F:tRNA-intron lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000379">
        <property type="term" value="P:tRNA-type intron splice site recognition and cleavage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042777">
        <property type="entry name" value="Sen15_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018593">
        <property type="entry name" value="tRNA-endonuc_su_Sen15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036167">
        <property type="entry name" value="tRNA_intron_Endo_cat-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28518">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28518:SF1">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09631">
        <property type="entry name" value="Sen15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53032">
        <property type="entry name" value="tRNA-intron endonuclease catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA-splicing endonuclease subunit Sen15" evidence="3">
        <location>
            <begin position="166"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="58"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="58"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM33778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="221" mass="25269" checksum="A93F35B56E9886F9" modified="2014-04-16" version="1">MMTDILEVTKQPEASAITERITEKGHESPHLATSAQVQHNLEHQHLWTSIIGDIIPGRSDDSNTLKKEPRQSPQEPIPLLSGYPPHRVYTHPDEQLYMLENEIRDEDLKPERIFVVPTTQGQPWTLRHMGAVFDRLPEFEQKAKEHDRSVGPTSMQPEAANLNPEKAEKLAQYYDKKEKTRLTKEWGAQRFLLAMVDKGMGGDGTVAYYVVHEGEVKPRQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W6QB36</accession>
    <name>W6QB36_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S03</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S03g000617</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QB36"/>
    <dbReference type="OrthoDB" id="10440474at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM33893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="52" mass="5636" checksum="AC25F9C3EE08B693" modified="2014-04-16" version="1">MVDEDGTYCVQLTKLVGSCFDRARGCGDVASSEIALAQIHWPSALQAMIYKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W6QB74</accession>
    <name>W6QB74_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Zinc finger, RING/FYVE/PHD-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PROQFM164_S02g001539</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QB74"/>
    <dbReference type="STRING" id="1365484.W6QB74"/>
    <dbReference type="OMA" id="CHGCAES"/>
    <dbReference type="OrthoDB" id="441210at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000795">
        <property type="term" value="C:synaptonemal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042448">
        <property type="entry name" value="CCNB1IP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14305">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE CCNB1IP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14305:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE CCNB1IP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14634">
        <property type="entry name" value="zf-RING_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="35"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="247"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="153"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="278"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="307"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM31389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="352" mass="39361" checksum="78BA4D10A493ECF5" modified="2014-04-16" version="1">MLTRDLHFFQGYALQPHPICNDTMDFSLRCNSLKCRAELKEKAVVTTCSHIFCHGCAESLGLSRPTTSNRLCPACQTALLNPDDAVSTILNPTEDYKTSVLSGLDPNTIMECAGRALAFWAYQSTQEIFYQEYRAKTLTEKYTNLNTQMDKVIHNANTEIMSLQNKLSDMQSSQEDLQKKNQELNDMYRDKNNKLAQMTNLYNLLKARAMRSRMQTAASDTVSQALSSLNAPVPDSALERASASIPLSNTSTLPSVPIIRHPKTPTFPVNPDGVEQLYRNQRSGTGSSKRARKRTPRGAPMPPPARPDWDGRNSKGRDPAPQHRTRLPRISRTPTFSSELPPGDAITQRFGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W6QB94</accession>
    <name>W6QB94_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S03</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S03g000687</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QB94"/>
    <dbReference type="STRING" id="1365484.W6QB94"/>
    <dbReference type="OrthoDB" id="420380at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="13"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM33963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="111" mass="12421" checksum="C7DED94DD0B796AB" modified="2014-04-16" version="1">MGSLPKLSTVLTWALYFVPLYIFILDPVVRGFFPSLVAPPSDSDELFDESSAPGPGINLTDDSFISPEDGVPFRCASAEEYRVHLLSREPLIIYIENFISETEANHILDMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W6QBH0</accession>
    <name>W6QBH0_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Gluconate transport inducer 1/Pac2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S03g000782</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QBH0"/>
    <dbReference type="STRING" id="1365484.W6QBH0"/>
    <dbReference type="OMA" id="PAYAWPP"/>
    <dbReference type="OrthoDB" id="5572844at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018608">
        <property type="entry name" value="Gti1/Pac2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28027:SF1">
        <property type="entry name" value="CAMP INDEPENDENT REGULATORY PROTEIN (AFU_ORTHOLOGUE AFUA_3G09640)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28027">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR MIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09729">
        <property type="entry name" value="Gti1_Pac2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="395"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="321"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="395"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="441"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM34058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="483" mass="51874" checksum="0393E9EFFCAA173B" modified="2014-04-16" version="1">METYYGHVRTPADAIILFEACRIGLLPRVQRRLSEKERQSIRSGSVFVWDEREAGMRRWTDGKSWSASRVSGSFLTYREMEGKRGGGSVSQGSASRGGKTPESRGSDDERADGTDEGPDGYRYKPDGLMKQSFSITTSNGQHLHLISYYSRSHPSAANLQQPTSDPALRHVRPQKGLYPESTVNDQQNLPVVTRGPMPGAAHPITPHPLGAYPRVTHTQPYPPAYAWPPTPLATPPTVSVQYGPGPSYLPPVGANGHPHYGPPHHQPPHQHGGLPLPPHGMTSPYDRPHMESTLPPAGPPPQQPSYMNRSPRSIHEHAHAHAQAQAHAHAQAQAHANAHAHAHAHEQRNAPVYGHLVDPRMASPRVPVQSLTQSNGHVHSPHLVKQEHPAALSSLNPIATSPKSSDPASTGNAVPGISSLMNGAALAPFPPSTASPGGPATSLNGNPAQSSFADGPRDIPNEKIGFGGEDTRALRQLDRAFIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W6QBJ9</accession>
    <name>W6QBJ9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S03g000130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QBJ9"/>
    <dbReference type="STRING" id="1365484.W6QBJ9"/>
    <dbReference type="OMA" id="CRDVLIW"/>
    <dbReference type="OrthoDB" id="4158087at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540">
        <property type="entry name" value="TRANSCRIPTION FACTOR (ACR-2), PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540:SF5">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM33406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="639" mass="71073" checksum="966D51A5BAFC8204" modified="2014-04-16" version="1">MDAKDLLPGYEQTLPVLSRPSAAAWAADPIHSPYAAPIHFDPNIHPIQTMASTPAPTPAPAPAPPPPKASSRKTTTRVRKPRKADNASTGKSTLFWVNSDQQTAAAGTTDETLKRIRSHVMSEHNRKKRMGNGEQSNKSKWKNSPCQPTTTTNTGALDTAGPVGSCIGSSVNLSSSQISDEQELEQVEELVTSTAVGYPAMQAASWNDSGFGGAVAYPSAWSYLGQGANDPFHTGHTHLTDRMMRHLRVFLWDLTQEAHPLQTRYKPKLQAHWASLIQRDPAILHATICMATSNDAMRAGELPIRDPNQKRSQLVIDTFHHRGETIRLVNEGLSDPVKASSDVLIAAVSTLLTIEIASGNPDYLKIHLAGLRQMIALRKNFDDVPSDVRFQISWTDIRVACMAHAKPIFPFVRYTRPARLSLIPPNDDVALLSTRLFPLLKIPGIFGEPMAQIVYDLLELSWYAEWIKGNTGYKEFNEETEDYFNTEVLHVEYQLHTDRYTMTGQVKGDNSIEGCTRLALLLFHNSAIWNFYPMIGQLLPKPIQALRIALEATIPSGLFALCRDLLLWQLFMGAACSLTLPSERAFFVSELANAARLQGIHSWQEARSILLGFFYVDRIHLPMLRQIWDECQLLVESPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W6QBV2</accession>
    <name>W6QBV2_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid/polyamine transporter I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PROQFM164_S03g000907</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QBV2"/>
    <dbReference type="STRING" id="1365484.W6QBV2"/>
    <dbReference type="OMA" id="WFNNFVG"/>
    <dbReference type="OrthoDB" id="2417308at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF22">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="125"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="282"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="328"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="385"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="409"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="450"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="481"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM34183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="544" mass="59871" checksum="C361A3718F402852" modified="2014-04-16" version="1">MDLEYNSQPLKPPLTDQHAQDAQDLADLGHSQALTRKFDMWSMLALAFCVLGTYSTFAQDLSSGLTNGGAITILWGLLLVTACNLCVALSLGELTSSMPTALGQAYWVYRLWDTPLGRFNSYMCAWINVFGWWTLTASQVAFMTEFLLGMKTMFDPEWDGANKGWLNFVVYIAVVFVLTLINVVSCRKEKILPWLNNFVGVWFFGLFIVLSLVLLISVGTKSNLSFQPASFVFGAWKNETGWGDGVVWFTGLVQAAYGLTAFDSVIHMVEEIPAPRKNAPRVIWMAVLFGAVTGFIFMVVCLFCIQNVDNVVNADLPFMELIVETVGLKGAAVLLALFIFNGLGQGISILTTASRLTWGFSRDGGVPFSNYFSHVDPVWQVPARALWGQSIVIGIVGILYLFANTVLEAILSVSTIALTVSYAMPILALLVVGRDKLPPGPFKLGRIGPWLNWVSIFYCIITTIFFLFPGSPNPAPSDMNFAIAVFGVMLVIAVAFWFIRGNRTYLQTEDAIASMVYAHHLELNEVGVDGSVPVVQAPVIVDYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W6QBY4</accession>
    <name>W6QBY4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Brl1/Brr6 domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S03g000937</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QBY4"/>
    <dbReference type="STRING" id="1365484.W6QBY4"/>
    <dbReference type="OMA" id="HPHIPRI"/>
    <dbReference type="OrthoDB" id="5961at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006998">
        <property type="term" value="P:nuclear envelope organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040202">
        <property type="entry name" value="Brl1/Brr6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018767">
        <property type="entry name" value="Brl1/Brr6_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28136:SF1">
        <property type="entry name" value="NUCLEUS EXPORT PROTEIN BRL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28136">
        <property type="entry name" value="NUCLEUS EXPORT PROTEIN BRR6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10104">
        <property type="entry name" value="Brr6_like_C_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01042">
        <property type="entry name" value="Brr6_like_C_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="231"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="339"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="Brl1/Brr6" evidence="3">
        <location>
            <begin position="229"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="368"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="426"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="426"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM34213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="447" mass="51217" checksum="3ED278FEA6EE5276" modified="2014-04-16" version="1">MDKRTGESPMDFEWQTRAPGDVTSPFYQLGAQHDKKRTYSAFESPQKQALPSLREPNSQPFLFSQPRQQPAPLSPKAKFGQPAFQTPRKFDVDFSSGAENMSSPEYADNEDTPEQQYKSGKGTSSLFNFHGRNPQSPGRGEIPRLTHHSNAALHRIQKKRRRDKELGRQIRVDSDDDSDQDRPSSREEKPVKATKQGKGEKFEQDRSRVSSWSEFFSMLEAHPNVPAILSWWAQLVVNLSLFSLAVYVVFGFVSAIRGEFEQAAQEMSDTILADMAVCTKNYIDNDCGRSSRVPALETICENWERCMNRDPAKVGRAKVSAHTMAIIINSFIDPISWKAILFFLATISTVTVFSNWSFRSLRQRLQQQNYAQHPPPPQSMHPQLQHNPSFGYYGQQDPRQTQGVAYDEKYDQPLMLENTRAMDFVTERSREREQHLRTPSPTKRRFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W6QDQ5</accession>
    <name>W6QDQ5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Major facilitator superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PROQFM164_S02g002435</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QDQ5"/>
    <dbReference type="OMA" id="NGFMSTW"/>
    <dbReference type="OrthoDB" id="6132182at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051617">
        <property type="entry name" value="UNC-93-like_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294:SF56">
        <property type="entry name" value="DUF895 DOMAIN MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294">
        <property type="entry name" value="ET TRANSLATION PRODUCT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="122"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="156"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="240"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="282"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="314"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="357"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="419"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDM32284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="466" mass="50939" checksum="AC9EB08827EE8A7F" modified="2014-04-16" version="1">MAPPVASEVVSEQVQDDSQTITRSRTSWYRSIPFQIAVASGVSFTAPGMWDALNNLGAGGAAEPYAVSAANALVYGLFAVVCIAAGAINNRIGLRYGLVLGAIGYPIYGAGLYTNTYHTTTWFMLFGSALCGISAGFFWAAEAAIIIGYPSPKERAFYIAVWQTAKSSGPIVGGAISLGLNAQTAGKGTISASTYIVFIVIMCLGLPISLLLSPAEKVQRKDHSLVVVNMKESWAKEFKAAFSLIFTRRVLLLLPAFFISYFYNGFQSTWLTTYFTVRSRAFSSFLTNFAGIASSFIMALLLDRQTIFIKTRARIAFCSVVALIIGTWIWATILQKQFYDLPESPVFDWFTPGFNKAYALIFFWTFSGQAFQQFLYWLVGQYSTDISSLSYHCGILRGFEALGQTVAWAMQTEGGANHFVSIGLNFGITVIAFVPTWIVLSELEHSHEVQVTVEDVPSKIADEATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W6QDS2</accession>
    <name>W6QDS2_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Prefoldin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PROQFM164_S03g001575</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QDS2"/>
    <dbReference type="STRING" id="1365484.W6QDS2"/>
    <dbReference type="OMA" id="WLWEDPK"/>
    <dbReference type="OrthoDB" id="198977at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005795">
        <property type="term" value="C:Golgi stack"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048211">
        <property type="term" value="P:Golgi vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048280">
        <property type="term" value="P:vesicle fusion with Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000296">
        <property type="entry name" value="Related to transport protein USO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006955">
        <property type="entry name" value="Uso1_p115_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024095">
        <property type="entry name" value="Vesicle_P115"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006953">
        <property type="entry name" value="Vesicle_Uso1_P115_head"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10013">
        <property type="entry name" value="GENERAL VESICULAR TRANSPORT FACTOR P115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10013:SF0">
        <property type="entry name" value="GENERAL VESICULAR TRANSPORT FACTOR P115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04871">
        <property type="entry name" value="Uso1_p115_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04869">
        <property type="entry name" value="Uso1_p115_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vesicle tethering protein Uso1/P115-like head" evidence="5">
        <location>
            <begin position="341"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="domain" description="Uso1/p115-like vesicle tethering protein C-terminal" evidence="6">
        <location>
            <begin position="1004"/>
            <end position="1143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="776"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1031"/>
            <end position="1103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1118"/>
            <end position="1143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="781"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1031"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1052"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1083"/>
            <end position="1096"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1118"/>
            <end position="1128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1129"/>
            <end position="1143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM34848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="1143" mass="127691" checksum="C6CBC4E22FFDC6BB" modified="2014-04-16" version="1">MFRILESQAPAKQTATDTIDVLSSRLQSATLLEDRRAAIQGLRSFAKLYPASVASGGLRSLISSLRNDSEDVDTIKVVLETLLMLFTPDESSPEASDEIALWLADEFTQRQDNITTLLNLLEAREFYSRLYSLQLMSHICSARPERTQECIFTAPLGISKLVNVLTDAREPVRNEALVLLIALTPASEELQKLVAFENAFEILFSLIEAEGALTHGTEVVEDCLSLLAHLLRFNVSNQSFFRETGCVKRVTHLLHECQQEPKDNEPAPQWTLVHRDKNVWGLLAIIQLFLIRGGMSTPINQTAFWQNGVTEQVLSIAFGQRFSVSVTSKALSTCADLIRGNSPLQERFGDIEVLWGSYPRGDKAVNGDANEPLRINVIEAFLKLSLEPAPNNLLDARLAACECMKAFFAHHPGIRMHVLRRAIEGHTSGQDRIPNILSVLLTAPEARGNADPYQVWMACVLMFHLIFDDAEAKAIAMAVTEGDAESGEEVVTSVQSVVGNLITGLQRGDDERITVGYLMLLCGWLFEDPDVVNDLLGEGSCIQTLLQEIKHQRTPSKLVPGLCTVLLGVIYEFSTKDSPIPRITLHKLLIEQLGREQYIDKITRLRECPLVRDFEVLPQTAGSQLEGGLPEVFFDRSFIEFLKDNFSRLLRAIDREPGFEISVVANGVEKGISRELVDSLRAEIEDRTQTLQTLESDLVSIQRRLDQEQLDHRKTKESNAIELSKIQQTNLSLQQRHAQELSQQLSKLQKEHNHHKNELLKQHNDQLRAIDHQLKQTSVESENKSSKAKEVREHHEREVVGLQQTIRGLESELSHMKEQHTGEVVNLNKRLQELETVISQSNQAHGIQVTDLQKKIEDLESTKKSHNGQVDNLSKKIQELQNTISQSKLAHGGQVADLEKKIQELENTKKSNDGLVADLNKQIKDFESIKGTHDGEVTDLTKKLQSLESTLAAAKQNHEAEVGEYKSKVESLESNLSTIKQKYEAESTGHNNTVGTLESNLAAAKKEHEAEIATLKQSVAVLKSDLAKAQKSSNDLETAQEGTVSQTSALEARAKEAEEKAREAESQARSAAEALKSMQAQLDKAKIEAKEKEEARQSAQSELEDLLIVFGDLEAKRMEDKERLKELGEEVSEAEDDDEDEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W6QDS7</accession>
    <name>W6QDS7_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SET domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S02g002465</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QDS7"/>
    <dbReference type="STRING" id="1365484.W6QDS7"/>
    <dbReference type="OMA" id="ISHMKDE"/>
    <dbReference type="OrthoDB" id="341421at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1410.10">
        <property type="entry name" value="set domain protein methyltransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050600">
        <property type="entry name" value="SETD3_SETD6_MTase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271:SF137">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271">
        <property type="entry name" value="UNCHARACTERIZED PUTATIVE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="1">
        <location>
            <begin position="21"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM32314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="428" mass="49043" checksum="E82A369740462C25" modified="2014-04-16" version="1">MKPEWWPGEEHEAFTEWAISNGIDINSVTPARFQGRGLGMMATRNIKKGEIVLQVPTQLMLRAEDIPSAFIDKLPEDIAVQALLAAYLTHAAPDELSKYDQWRNSWPSRKDFEDSMPILWPTVLGGPQLPNSKDDASTDSKQPSLLPPSISGLWNTLQPGPKTRKYSSDHQNILSQQAQRLRKAWTDVISVFPETNWETFSYNWLIVNTRSFYWIGEGQETPEDPNDAMGLVPFADYFNHADVARDVRFDESVYEFRATKDYEEGEEVFMNYGSHPNDTLLAEYGFFLDVNEADSIYLDDIVFRDIQTAEQQEELWLNQYHGNYQVTPHGPCYRTEVAACLSYMKEKDWRNHVLEGQSEGLDESRSEATIKRWIQTYAAEADATITALQKTMELDTTVQAHRSKAEMLLRRLKQIKELCDHAAKTVSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W6QDU7</accession>
    <name>W6QDU7_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Short-chain dehydrogenase/reductase SDR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S03g001615</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QDU7"/>
    <dbReference type="STRING" id="1365484.W6QDU7"/>
    <dbReference type="OMA" id="VHMTKAM"/>
    <dbReference type="OrthoDB" id="47007at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000620">
        <property type="entry name" value="3-oxoacyl-(Acyl carrier protein) reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005559">
        <property type="entry name" value="PRK07231.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF124">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM34888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="269" mass="29081" checksum="B5D2ECBF468875E2" modified="2014-04-16" version="1">MPQTSRLQDKVAIVTGSSSGLGRAIAIRYAQEGAKVVCADLTPTARSQEESNITTHDLIVRDGGQAKFVKTDVGDAKQMENLVQVAVKEYGRVDILVNNAGISIEARTPAVLHLTDETTWDMTMRVNTKSVFLGCKYALSQMLAQEPHSSGDRGWIINISSIMGMIGGPENPSYCASKGAVSNLTRQMALDYASDNIHINAICPGYTQTAIFKETITNLTPWEDLKRRHPLKGPGTPEDIARIAVVLASDDANWMTGVCLPVDGGYTAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W6QEA3</accession>
    <name>W6QEA3_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein phosphatase 2C homolog 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">PTC5</name>
        <name evidence="4" type="ORF">PROQFM164_S03g001795</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM35068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QEA3"/>
    <dbReference type="STRING" id="1365484.W6QEA3"/>
    <dbReference type="OMA" id="DHNAWNP"/>
    <dbReference type="OrthoDB" id="420076at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004741">
        <property type="term" value="F:[pyruvate dehydrogenase (acetyl-transferring)]-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832:SF792">
        <property type="entry name" value="GM14286P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="61"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="PPM-type phosphatase" evidence="3">
        <location>
            <begin position="197"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="335"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="344"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM35068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="598" mass="65795" checksum="DEC1CFC4EB903E12" modified="2014-04-16" version="1">MRRATVQACRTARLAPVWNIAAKRPCPLTFNHLRGIRPYTGSRRSSHTPVASQLSMHRRKLSLAVISTVVASGAWYTYQGDTVKSAATQIRDFASSALNSAYAEGPAETTRRALLVSGDQFYTTTLSKDQPLAKHTDDSDRQVLEMLTPEQATQKLRKNEESYLVNRGKGVVRYDVVQVPSNSPIEDDHAEKIVEIPASVAAVSNGEPSSDWMFWGVFDGHSGWTTSAKLRNVLISYVARELNTTYKAASADPSLLVPTSEAIDAAIKKGFVRLDNDIVHESFKEVMKSKSRRVAAELLAPALSGSCALLSFYDSQSKDLRVAVTGDSRAVLGRRGPSGKWTATALSEDQTGGTPSEIKRLREEHPGEPYVTKNGRILGQLEPSRAFGDAFYKWSRDVQDTIKAKFFGRTPHPMLKTPPYVTAEPIITTTKIDPSKGDFVVMATDGLWEMLSNEEVVGLVGQWVEQQQSAAASTGSKAWLQSWFRFDSQKTLPVEAASDASSEGQRRPIRQQQYDISGAATRFVVEDKNAATHLVRNAMGGKDKDMVCALLTLPSPYSRRYRDDVTVEVIFFGQGPDSRTVEVNQEASASEQPPKSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W6QEK6</accession>
    <name>W6QEK6_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PROQFM164_S03g001622</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QEK6"/>
    <dbReference type="STRING" id="1365484.W6QEK6"/>
    <dbReference type="OMA" id="CNKQADR"/>
    <dbReference type="OrthoDB" id="3639251at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000409">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000511">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF47">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="206"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="280"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="321"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="345"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="371"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="404"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="437"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="46"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM34895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="482" mass="53737" checksum="272287A403196DE2" modified="2014-04-16" version="1">MTPIDEKLPADHRIEDIVGKNLPSDDDDEFTPQEQKKIIRRIDLRLVTMTGLAYCISLMDRTNLSMAAVAGLKKELRLDIGERYSIVVLMFFVPYILFQPPMTVIIRKVGPTYFLGSIILCWAGIMIGMGFVQDWGALVGTRVLLGVLEAGYFPGCVYLLSCWYTRYDVQKRFSVFYLIGCVASALAGILAFGLMQLNGKQGLTGWRWIFILEGVITGCIGILCFFFLVDFPDRAHKSWNFLNERECAFIIRRINKDRNDGDMEAFSLKKFLKPAVDLKIWGFAMIFFCLTTVTYAIAYFLPIILMSGMGYGVGQAQCLVAPPYGFAGIVMYATAWVGDKYHMRAPILIFNALLAIIGLPLMGFAKSDAVRYFGVFFTVAGANANIPACMAYQANNVRGQWTRAFSSATLVGFGGLGGIVSSLVFREQDAPEYRPGMYAAIGCNILIVLLVLGLSLWFRICNKQADRGKRVIEGDAAFRYTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W6QF53</accession>
    <name>W6QF53_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alkaline-phosphatase-like, core domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S01g002033</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QF53"/>
    <dbReference type="STRING" id="1365484.W6QF53"/>
    <dbReference type="OMA" id="FMWNRIA"/>
    <dbReference type="OrthoDB" id="103349at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052701">
        <property type="entry name" value="GAG_Ulvan_Degrading_Sulfatases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43751">
        <property type="entry name" value="SULFATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43751:SF3">
        <property type="entry name" value="SULFATASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="38"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="100"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="145"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase N-terminal" evidence="3">
        <location>
            <begin position="460"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="874"/>
            <end position="897"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM28222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="897" mass="102200" checksum="3D501CF301598156" modified="2014-04-16" version="1">MTMKVVHAVHAYLSHGIRRVRLSPGETLDAVWDFARRYFFTLAVLSLFSAKLLHLYAHIYSLPLPRLFLWGLTFFFQDVMLLLLFRILAQKVAWRPGAALLAILVIPSSLIVSFMAAANTSFYVFTGAEIHWRQAKSFNGDAAAIHTLLTGLTGFLIVEAILLTISLFAAHSIHAISGGILHVWAWPVRWLFGRLRPHVEPLVQRFWPRSKSSVADLPDPRIYEQIAMDDNDDLSDNEEGDHLLNTARLPNRLPASKRVTDGVPQRALVLGLFSLFLLLRFMRPWDPVYMYMSTTLPLTTIIEGAERQSPVDTAGTPSRFEYLDRITALGPAPQWTWMSKEPLEGFEDWDQSDPLALHYDPHGDPLHISNLDKPVLQEIHNALASGDVKIKHVVFLKLESARADIFPLQKDSFMYKRIAETWKNKTIPQEVVERLANLTRTAEFLTNFPTGFEHDDTRFGRKAYGGISAKDAITSSTYTLKSLTGSFCGVTPLVADFNREFEHHIYQPCLPQVFDTLSQQPDINSETDDFTKWPWHSTFMMSVTEMYDNQFKLTPHLGFRDKQTKETIIKPDAKHFPVKSAEVNYYGYPETELREYIRDAIDDAERDHQRLFLTHLTSTTHHPWGIPNDAFEEMMGAKSGANGDMNRYLNSVGYVDDWLSELIDILEEKGVANETLFVMAGDHGLSLPNDGGITPYDNPHVGSFKVPIVIAHPLLPPVQIDTPVISTQIVPTIIDLLIESASLSQDSTRAARDIRSLYEGQSMIRPQVVKQDGREAWHFTVMNTGGSWLSVRSAARPEFRLVIPLVNDVEWRFTDVSKDPNELSPIERFSLADLASAVQDEYEDEEIMNWLYHAAYVTNWWVLENWDRWRFSPKAKDEAKEEPPKEEPKEEPKEDKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W6QFN2</accession>
    <name>W6QFN2_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BTB/POZ fold</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S02g003140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QFN2"/>
    <dbReference type="STRING" id="1365484.W6QFN2"/>
    <dbReference type="OMA" id="CEFASVQ"/>
    <dbReference type="OrthoDB" id="6359816at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843:SF5">
        <property type="entry name" value="BTB_POZ DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="27"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM32989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="257" mass="29044" checksum="7542FB2C00CEA2B6" modified="2014-04-16" version="1">MSNTSSSQPQRIINRVSERCRERGDYTDFKIMCDGVDFGVHKVILCSQSPIFRAACTGNFRATADSTYQMTDESIPVVKKMLDYLYTGDYSELIDDSPTDVSPNVPLLSISALRLHAQLFALGDKYCIPELCDAAMGKYLNRTVGHFDPFEYLDSIPDVFFSPFSNSKGLKEFAVCLSRDKLGFHLRDTSVRAKYDSIAAQVPEFVKEMLDTFFDAPLLGDCENCGLRRPMSVLQVRCRKCGRGKDMSHSRRGFKDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W6QG84</accession>
    <name>W6QG84_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Oxalate decarboxylase oxdC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">oxdC</name>
        <name evidence="7" type="ORF">PROQFM164_S02g003356</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="3">Binds 2 manganese ions per subunit.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM33204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QG84"/>
    <dbReference type="STRING" id="1365484.W6QG84"/>
    <dbReference type="OMA" id="HARTFNY"/>
    <dbReference type="OrthoDB" id="10263073at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033609">
        <property type="term" value="P:oxalate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20305">
        <property type="entry name" value="cupin_OxDC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20304">
        <property type="entry name" value="cupin_OxDC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017774">
        <property type="entry name" value="Bicupin_oxalate_deCO2ase/Oxase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006045">
        <property type="entry name" value="Cupin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051610">
        <property type="entry name" value="GPI/OXD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03404">
        <property type="entry name" value="bicupin_oxalic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35848">
        <property type="entry name" value="OXALATE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SLL1358 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
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        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
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        <location>
            <begin position="19"/>
            <end position="454"/>
        </location>
    </feature>
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        <location>
            <begin position="116"/>
            <end position="258"/>
        </location>
    </feature>
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        <location>
            <begin position="293"/>
            <end position="436"/>
        </location>
    </feature>
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        <location>
            <begin position="42"/>
            <end position="112"/>
        </location>
    </feature>
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        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
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        <location>
            <position position="399"/>
        </location>
    </feature>
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        <location>
            <position position="160"/>
        </location>
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            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
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        <location>
            <position position="162"/>
        </location>
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        </ligand>
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        <location>
            <position position="166"/>
        </location>
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            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
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        </location>
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            <label>1</label>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CDM33204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="454" mass="51387" checksum="2374BBF636A46D73" modified="2014-04-16" version="1">MQITRFLLNLAYLQAVWAIPAPDHSLQKLLQVPAGHSAALFGQQPIGKNPPFSPGHRDPYDHKVDSVGDDRHPLPFRNGDGTTVMGPRNRDRERQNPDLVRPPSTDHGNMPNMRWSFADSHIRIEEGGWTRQTTIHELPTSRELAGVNMRLDQGVIRELHWHTEAEWAYVLAGKVRVTALDLEGGTFMDDLEEGDLWYFPAGHPHSLQGLGENGTEFLLIFDDGNFSEESTFILTDWLAHTPKAVLGENFRMSPEQFDNIPKSEKYIFQGSNPGSIDEEKPRTFKKSKINFTHHMLAQEPIKTSGGRVRITDSTNFPVSKTVAAAHLEIAPGALREMHWHPNADEWTYYKKGRARVTIFAAEGNARTFNYMAGDVGIVPRNMGHFVENLSDDEPLEVLEIFRADRFQDFSLFQWLGSSPRRMIAENIFPGDAKAAEEFLKKIEDAEKDPIKDTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W6QGC2</accession>
    <name>W6QGC2_PENRF</name>
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        <submittedName>
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        </submittedName>
    </protein>
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    </gene>
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        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
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    <dbReference type="Proteomes" id="UP000030686">
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    </dbReference>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="162" mass="17971" checksum="630C35CFA4F04EDB" modified="2014-04-16" version="1">MSLPQPLPLEPDALYILLFDLGGSCLFEWRLYLASTHTTGQTFHITNETGPVNWQYKSEAVYNIASDMRVVLALQIGVVGPVLHAALGSRLALIPLTLYSARFREGLSCRVWVQEGLFALDDEGYLDLTRSVADIEQEARQLGMLNKSRGSRSVVRSRGFVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
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    <name>W6QHJ1_PENRF</name>
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        <recommendedName>
            <fullName evidence="8">Thioredoxin</fullName>
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        <lineage>
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            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM164</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
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    </dbReference>
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        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46115">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PITH"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
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        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="4">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="PITH" evidence="5">
        <location>
            <begin position="130"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="162"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="173"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDM33664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="332" mass="35685" checksum="6EAE673AB8C066EB" modified="2014-04-16" version="1">MSVIEISSKEQFSSLLTSSRLVVADFHADWCGPCKAIAPAYNALATQLSRPNHITFTKINVDHQQELAQAYGVTAMPTFIVFKNGRVNQTVKGANPAQLNQIVQKLASEASQTDDAAGAGEGSSSGELWLGSTVAKGYSDITDQVNVKGLELLNRDTDTAEPRALFNSSKPSGLAANGKGKAAGQADWTESDTDEQLMLYIPFNSILKVQSLQITSLPPADADADADETPMRPKNLHIYKNTSHVLGFDEADGIPPVQKVEIQSGDWDAKTGTATVSLRFVNFQNVTSLVLFFVDGDGDSEKLRVDRIRIIGEAGANRSMGKLEKIGDEPGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2024-10-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>W6QIB5</accession>
    <name>W6QIB5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S01g003129</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QIB5"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM29317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="56" mass="6412" checksum="323080CDD17CFA5B" modified="2014-04-16" version="1">MNQPFRIPGRYVLIGNREDFDTGMSGYSISTLGRAWKWKHGYTNRHGAIEGRQATI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W6QIE3</accession>
    <name>W6QIE3_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Complex 1 LYR protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S04g000642</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QIE3"/>
    <dbReference type="OMA" id="QWRHLFR"/>
    <dbReference type="OrthoDB" id="5521299at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd20273">
        <property type="entry name" value="Complex1_LYR_unchar"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046896">
        <property type="entry name" value="Cup1-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20263">
        <property type="entry name" value="LYRM2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LYR motif-containing protein Cup1-like N-terminal" evidence="1">
        <location>
            <begin position="22"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM35761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="327" mass="37834" checksum="81B0AC1E9CA7F76A" modified="2014-04-16" version="1">MAGPQSQHWVQNLSKPHQWRHLFRATLRECTYLPDPIARNYMKDHIISRYRAVSSRSPKAGPQAVHAARNALSVLRRANEGYARPLEKVLLLSYGRTGRRRHELLAKILTPQIPNDSMALKELISQPVDFSDGWEPPAIVKNLAISQMQNPVVTAVRIRPLIKQFQPPIPKEDSWGRELAQCRKKNIRKKWYNNTLNSLLPPLPEKDLQTLEGLISGTVPWEPVKRRNSKPQVFQTESGGELFRLLARGPEKGTTFAEYANGRPHTITIRLMRRQWRRLSALVPRQYWNPISQKWRFLWDSPKEVPRLSFDLDSSIDPEAFFKEFSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W6QIN5</accession>
    <name>W6QIN5_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Sugar phosphate phosphatase</fullName>
            <ecNumber evidence="7">3.1.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PROQFM164_S01g003269</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Metal-dependent phosphatase that shows phosphatase activity against several substrates, including fructose-1-phosphate and fructose-6-phosphate. Its preference for fructose-1-phosphate, a strong glycating agent that causes DNA damage rather than a canonical yeast metabolite, suggests a damage-control function in hexose phosphate metabolism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>beta-D-fructose 1-phosphate + H2O = D-fructose + phosphate</text>
            <dbReference type="Rhea" id="RHEA:35603"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:37721"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:138881"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>beta-D-fructose 6-phosphate = dihydroxyacetone + D-glyceraldehyde 3-phosphate</text>
            <dbReference type="Rhea" id="RHEA:28002"/>
            <dbReference type="ChEBI" id="CHEBI:16016"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="7">
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </cofactor>
    </comment>
    <comment type="domain">
        <text evidence="7">Subfamily III proteins have a conserved RTxK motif about 40-50 residues from the C-terminus; the threonine may be replaced by serine or cysteine.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the damage-control phosphatase family. Sugar phosphate phosphatase III subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.-" evidence="7"/>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QIN5"/>
    <dbReference type="STRING" id="1365484.W6QIN5"/>
    <dbReference type="OMA" id="IFARQKM"/>
    <dbReference type="OrthoDB" id="541375at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097023">
        <property type="term" value="F:fructose 6-phosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103026">
        <property type="term" value="F:fructose-1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.930.60:FF:000002">
        <property type="entry name" value="Protein-glutamate O-methyltransferase C1393.13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10880">
        <property type="entry name" value="Uncharacterised protein PF01937, DUF89, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036075">
        <property type="entry name" value="ARMT-1-like_metal-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039763">
        <property type="entry name" value="ARMT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002791">
        <property type="entry name" value="ARMT1-like_metal-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12260">
        <property type="entry name" value="DAMAGE-CONTROL PHOSPHATASE ARMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12260:SF6">
        <property type="entry name" value="DAMAGE-CONTROL PHOSPHATASE ARMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01937">
        <property type="entry name" value="ARMT1-like_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111321">
        <property type="entry name" value="AF1104-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7" id="KW-0464">Manganese</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Damage-control phosphatase ARMT1-like metal-binding" evidence="8">
        <location>
            <begin position="23"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM29457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="475" mass="53349" checksum="FA4D84285044F8BC" modified="2014-04-16" version="1">MEFDPKTPQYLTSDKSSFASVSANERWPVIITGAIDDLHRTVVAVKDGEKANEGKGIIAKLASLKYELQHDRQLTPLDDDGHPDIASYNKELEERGNPHWHDVAWLYAECYLYRRMEALFALSKHWKGYDVFARQKMDTFKSSRPAVLELAARYRELATESESGKARENKSPEEIDSAEKLLFSEMCEICLWGNATDLSLLTSLTYEDIQKLQGSEARKASEQNIIVNDLDAAFGVMQKARREKKDGDRRVDIVLDNSGFELFVDLILAGYLLSAGLATSVVLHPKRLPWFVSDVTPKDFSDLLNCMVDPQAFYTAIDGSGKTFPPLSDKEVSDVRFLFEQWSQFHQDGKLILRPHAFWTTQGGYWRMPFVAPELFEDLKESELVLFKGDLNYRKLVNDAQWDPTTPFTEAIGPLGPKSGIRVLAFRTCKADPVVGLPAGEDEKLRALPGGGGAESRKWAWGGKWAVVSLSDGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W6QIR9</accession>
    <name>W6QIR9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S04</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S04g000777</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QIR9"/>
    <dbReference type="STRING" id="1365484.W6QIR9"/>
    <dbReference type="OMA" id="ENVPIYN"/>
    <dbReference type="OrthoDB" id="5405126at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM35896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="362" mass="40781" checksum="7A2D7A6E07B20A26" modified="2014-04-16" version="1">MAQIAMSRLFRQSTTGSVRQSILRPMQARSYGSNSVIPTFTSTSSPELDEALERFRNELFIPLALPKRQRKSVFREKYAKQLENEPITVKIGETEEFTLTPKKHHDLPSKKDALEVLKLMVATKNYSNLFPYLSGLRMSNYAINSDRWEFIIRKTSAASKLSTIIECAKQSHRTGLTLSNRNIARRLFFELHKTAAKANFEGAPTVKALKLAREAASLMDADEHSVRNLEDDPKHQPFVIGTLLELSAACAKIDETQIGLVRSYSQKLDAAWSRGNFQDDASTGFENIERVEENLAVYNGMRLALELPRASHDTGNFQARCDKLKPILISQLEKVKNADVLADNVVKQLLADKPKQKIETNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>W6QIZ7</accession>
    <name>W6QIZ7_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">6-methylsalicylic acid synthase</fullName>
            <ecNumber evidence="5">2.3.1.165</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PROQFM164_S05g000213</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM164</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.3.1.165" evidence="5"/>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1365484.W6QIZ7"/>
    <dbReference type="OMA" id="SWVTHTT"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050641">
        <property type="term" value="F:6-methylsalicylic acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901336">
        <property type="term" value="P:lactone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05274">
        <property type="entry name" value="KR_FAS_SDR_x"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.250">
        <property type="entry name" value="Malonyl-CoA ACP transacylase, ACP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049552">
        <property type="entry name" value="PKS_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF22">
        <property type="entry name" value="SYNTHASE, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21089">
        <property type="entry name" value="PKS_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01294">
        <property type="entry name" value="PKS_PP_betabranch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="9">
        <location>
            <begin position="32"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="10">
        <location>
            <begin position="926"/>
            <end position="1202"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="8">
        <location>
            <begin position="1700"/>
            <end position="1774"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="6">
        <location>
            <begin position="926"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="6">
        <location>
            <begin position="1059"/>
            <end position="1202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="6">
        <location>
            <position position="958"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="6">
        <location>
            <position position="1114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDM36380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="1776" mass="190687" checksum="7650C92D96C100CB" modified="2014-04-16" version="1">MNSVSPSTYPSGKTSPAPAETPKTEYSEYEFSTDVAVVGMGCRVAGGNHSPELLWQSLLSQKSAVSEIPPMRWEPYYRRDPRNAKELKKTTSRGYFLDRLEDFDCQFFGISPKEAEQMDPQQRVSLEVASEALEDAGIPAKSLSGSDTAVFWGVNSDDYSKLVLEDLPNVEAWMGIGTAYCGVPNRISYHLNLMGPSSAVDAACASSLVAIHHGVQAIRLGESKVAIVGGVNALCGPGLTRVLDKAGAISSDGSCKSFDDDAHGYARGEGAGALVLKSLHRALLDHDNVLAVIKGSAVAQDGKTNGIMAPNAKAQQLAARTALTVAGVDPSTVRYVEAHATSTPLGDPTEISAIAGVYGTDRHADDPCYIGSVKPNIGHLEAGAGVMGFIKAILTIQKGILPPQANLTKLNSRIDWDKAGVKVVQEATPWPSSDPIRRAGVCSYGYGGTVSHAVIEEFSHVLQPDPLDDGAVTGPGLLLLSGPQEKRLALQAKTLREWMAAEGKDHNLSEVLTTLATRRDHHDYRAALVVDDHLDATQVLQALVNGVSHPFTTQSRVLGTEISKDVVWVFSGHGAQWPDMGKQLIHNPVFSAAIQPLDELIQAEIGLSPIELLRTGDFESSDRVQILTYLMQIGLSAVLQSNGITPQAVIGHSVGEIAASVVAGALSPAEGALIVTRRALLYRQVMGKGGMILVNLPSGEAEQILGSRQDLVVAIDSSPSSCVVAGDKEIVAEAVEAFKARGVKTFTVKSDIAFHSPTLNGLMDPLRDALGQTLAPTAPTIKLYSTALVDARGQDLRDVEYWTGNMVNRVRLTTAIQAAVEDGYRLFLEVSAHPVVSHSINETLMDAGMENFAVIPTLLRQKPTEKHILHSIAQLHCRGAEVNWAAQMPGRWATGLPTTTWMHKPIWRKVETAPLNTGLTHDVEKHTLLGQRIAVPGTDTFVYTTRLDNETKPFPGSHPLHGTEIVPAAGLINTFLKGTGAQVLQNVVLRVPVAINAPRSVQVVVQQDQVKVVSRLIPSEPSLLDDDASWVTHTTAYWNRKVLGPVDRIDLAAVNARLVTKLPDNFSIDYLDKVGVSAMGFPWAVTEHYRNTKEMLARVDVNPAVLGDAPLPWDSSSWAPILDAATSIGSTVFQTAALRMPAHIERVEIFTSEDPPKISWLFVKEASDAVPTSHVSVLSKTGEVLAKFTAMRFSEIEGTPGVSGSMESLVHQIAWPPATPAEEPLPIMTVIMISPDAATLAKYAATLPTQIQSFQFSGTEDFFSNALSLPLEKGTVVAYIPGEVASLAEIPAASESFTWNLLELIKFIVNGSLPIKVFTLTANVGDGQTATALAQSPLFGLARIIASEHPDLGSLIDIEEPIIPLSTMRYIHGAGIIRISDGIARTSRFRSLPRSKLRPVSDGPRLLPRAEGTYLITGGLGILGLEVADFLVEKGARRLLLISRRALPPRRSWDQVSTDLQPAIAKIRLLESRGASVHVLPLDITKSDAVEQLSTALDRLALPAVQGVVHAAGVLDNELVMQTTRDAFNRVLAPKIAGALALHEVFPPKSVDFFIMFSSCGNLVGFTGQASYGSGNAFLDTLATHRARLSDSAVSFQWTSWRGLGMGASTDFINAELESKGITDITRDEAFSAWQHLAKYDMDHGVVLRSRAFEDGEPVPVSILNDIAVRRVGALSGNTPVVAGSNGSDAIPSSGPELKTYLDEKIRGCVAKVLQMTAEDVDSKAALADLGVDSVMTVTLRRQLQQTLKVAVPPTLTWSHPTVSHLVVWFAEKIGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W6QJC7</accession>
    <name>W6QJC7_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ADP-ribosylhydrolase ARH3</fullName>
            <ecNumber evidence="2">3.2.1.143</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">ADP-ribose glycohydrolase ARH3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">ADP-ribosylhydrolase 3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">O-acetyl-ADP-ribose deacetylase ARH3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Poly(ADP-ribose) glycohydrolase ARH3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">[Protein ADP-ribosylarginine] hydrolase-like protein 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">[Protein ADP-ribosylserine] hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PROQFM164_S05g000741</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>alpha-NAD(+) + H2O = ADP-D-ribose + nicotinamide + H(+)</text>
            <dbReference type="Rhea" id="RHEA:68792"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:57967"/>
            <dbReference type="ChEBI" id="CHEBI:77017"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="12">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ADP-ribosylglycohydrolase family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.143" evidence="2"/>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QJC7"/>
    <dbReference type="STRING" id="1365484.W6QJC7"/>
    <dbReference type="OMA" id="PGTWTDD"/>
    <dbReference type="OrthoDB" id="2021138at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004649">
        <property type="term" value="F:poly(ADP-ribose) glycohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4080.10">
        <property type="entry name" value="ADP-ribosylation/Crystallin J1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050792">
        <property type="entry name" value="ADP-ribosylglycohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005502">
        <property type="entry name" value="Ribosyl_crysJ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036705">
        <property type="entry name" value="Ribosyl_crysJ1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16222">
        <property type="entry name" value="ADP-RIBOSYLGLYCOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16222:SF24">
        <property type="entry name" value="ADP-RIBOSYLHYDROLASE ARH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03747">
        <property type="entry name" value="ADP_ribosyl_GH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101478">
        <property type="entry name" value="ADP-ribosylglycohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="12">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="271"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00041057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00042398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00042471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00042722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00042850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00043187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00043193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR605502-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDM36908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="320" mass="34938" checksum="D1775483F9FB8230" modified="2014-04-16" version="1">MSLSSKSRAQGAIWGVCVADALGGPVQFKAAGTFEPITCLRSWKQPAGSYSDDGSLTLALACSFNKSQMQYNHTLAIHNFVAWLTKGQFSTINRSWDVGRSTRTSLKLWSKRGIDKGELDVAQALVNSKLDHDEFSGNGSLMRIVPIGLVYWRDSGLAREIARTHSRITHPSLACVEACEAYTELVCRVMNGQTKEQLYQAVSEFPFTHAGLKERLSPSRYGTISDWKSKEPRDMTSSGWVIDTIECALWAFFKYDTWKDGALAVVNLGGDSDTAGAVYGGLAGSFYGFDTIPSEWVDGMQKKGFIESIAGALSDGIARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W6QK00</accession>
    <name>W6QK00_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Replication factor C subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PROQFM164_S06g000109</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the activator 1 small subunits family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792020">
        <property type="protein sequence ID" value="CDM37148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QK00"/>
    <dbReference type="STRING" id="1365484.W6QK00"/>
    <dbReference type="OMA" id="LKADIMH"/>
    <dbReference type="OrthoDB" id="761538at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031390">
        <property type="term" value="C:Ctf18 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005663">
        <property type="term" value="C:DNA replication factor C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031391">
        <property type="term" value="C:Elg1 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031389">
        <property type="term" value="C:Rad17 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000030">
        <property type="entry name" value="replication factor C subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.272.10:FF:000002">
        <property type="entry name" value="Replication factor C subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000136">
        <property type="entry name" value="Replication factor C subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050238">
        <property type="entry name" value="DNA_Rep/Repair_Clamp_Loader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669">
        <property type="entry name" value="REPLICATION FACTOR C / DNA POLYMERASE III GAMMA-TAU SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669:SF1">
        <property type="entry name" value="REPLICATION FACTOR C SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13177">
        <property type="entry name" value="DNA_pol3_delta2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21960">
        <property type="entry name" value="RCF1-5-like_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22534">
        <property type="entry name" value="RFC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="6">
        <location>
            <begin position="34"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00070185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM37148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="352" mass="39831" checksum="89E163DEFFA5AA7A" modified="2014-04-16" version="1">MALLVDKLRPRTLDALTYHPELSDRLRSLAQSGDFPHLLVYGPSGAGKKTRVIATLKELYGPGVEKIKIDARVFQTTSNRKLEFNIVSSVYHLEITPADVGNYDRVVVQELLKEVAQTQQVDLGAKQRFKVVVINEADHLTRDAQAALRRTMEKYSPNLRLILLANSTSNIIAPIRSRTLLVRVAAPTEADICSALHLAGKKEGWTESQVLNKRIAKESGRNLRRALLMFESIYAQNEKVTDKTLIPPPDWEALVALTADEIMAERSPARLLQVRARLYDLLTHCIPPTTILKTLTFKLVARVDDALKPEVIKWSAFYEHRIKLGSKIIFHLEAFVAKFMRIYESYLMGMDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W6QKM3</accession>
    <name>W6QKM3_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GTP binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S06g000324</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792020">
        <property type="protein sequence ID" value="CDM37363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QKM3"/>
    <dbReference type="STRING" id="1365484.W6QKM3"/>
    <dbReference type="OMA" id="FCILDRY"/>
    <dbReference type="OrthoDB" id="59699at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00882">
        <property type="entry name" value="Ras_like_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018712">
        <property type="entry name" value="Tle1-like_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33840:SF1">
        <property type="entry name" value="TLE1 PHOSPHOLIPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09994">
        <property type="entry name" value="T6SS_Tle1-like_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T6SS Phospholipase effector Tle1-like catalytic" evidence="2">
        <location>
            <begin position="76"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="G" evidence="1">
        <location>
            <begin position="427"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM37363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="950" mass="107705" checksum="327A25A4B7A6ECE8" modified="2014-04-16" version="1">MKNIRKRHVILVDGPWYNDEGELHYGSGGKSTIWRIGSATKEGKVADDKGDVNQVIRYFKSSKKSIIDRTKELVDICKSASTEDEIWLFGFSKGALAIRAVVDLLWAAKRDEHRPVQRSFSSFFKLKKSSSSLVELEKWIRESGAKKCLPKLCFVGLFDTIHDSSVDQSLQWPASIYLYHAASMHEDDNTLKVRLLSEDASKNAYETPKYVEAWFAGSHIDIGGGANQDGLSLYPLQWMLIEAQKKGLCLNKPILPGKKEGQLVEDIVQLVFPSSGKTLDSKSSVIDPWTLRYANNLTIQLYNLRISHQHGNLQHEQDQRPKKNVLIQARKEPGNHRIPANQRHNVRLNKTRPYTQHRYGGSGSIYRAIFASEETDTPSASSNELVNELPRELSLDLQRFRETKLLKEKQFDPWVSAYNLDHLPKCRILVCGATGVGKSTLLNAVFGIELTQTSDKESVSHDINEALESDLHPGIIIHDSRGFQYGESKEVNILRDFIEQRQKSADPNERLDVIWLCIEVSSKRRLQPAHAELFHVLKEFDCHTPVIVVRTQMDKELKERQFDILGAAAEGQKQNESKEPNGLAWEVIKAQAEKEFFEAERPFEMDVKKHDPKACVVHTSKDTDSSIRKLVRTTLEEVERYSPERKTSVAAALRRDMDFKIGVAIQRTFDMINYDAHMWQRVIAAIPLTDSTTTPIMCRVLCSRILSCFGLPKIPPDAAAHVFSKVILRNLSRFMMESIGTDFWNILAGANKLLLFGIAPIPKAMWPAARMVVKCACDVIIILDGAIKQSGFMATPENLHEVQMAYALNYNPDELPGSEKMTLRQLTHKDVNREFKLSKEFNQKLEYQVARQKMMRIVMTHRLKEKAHFRASAPSFYQETENQDALDALFSGDSNTLGQEIDALAQLGADGCMSGQYDEEIADQYSEYMYSQDMDDSLCRSSVCFDDSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W6QLS6</accession>
    <name>W6QLS6_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Cholesterol oxidase</fullName>
            <ecNumber evidence="16">1.1.3.6</ecNumber>
            <ecNumber evidence="14">5.3.3.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Cholesterol isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">PROQFM164_S05g000774</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">FM164</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="15">Steroid metabolism; cholesterol degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell envelope</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.3.6" evidence="16"/>
    <dbReference type="EC" id="5.3.3.1" evidence="14"/>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QLS6"/>
    <dbReference type="STRING" id="1365484.W6QLS6"/>
    <dbReference type="OMA" id="KEFCFLG"/>
    <dbReference type="OrthoDB" id="9974421at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016995">
        <property type="term" value="F:cholesterol oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004769">
        <property type="term" value="F:steroid Delta-isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008203">
        <property type="term" value="P:cholesterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052542">
        <property type="entry name" value="Cholesterol_Oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-dep_OxRdtase_2_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47470">
        <property type="entry name" value="CHOLESTEROL OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47470:SF1">
        <property type="entry name" value="FAD-DEPENDENT OXIDOREDUCTASE 2 FAD BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0153">Cholesterol metabolism</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0274">FAD</keyword>
    <keyword evidence="7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="19" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="11" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="789"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="20">
        <location>
            <begin position="27"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00038856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00049744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00049778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="CDM36941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="1200" mass="133310" checksum="46065AAEDBE56A39" modified="2014-04-16" version="1">MSNFTDRTDKYPNLSRPFRSMRPEYDVVVIGSGYGAGVAASRMARAGKSVAVLELGWERRSGSFPQTFSQCLKNTSISGSSVKGSFISKWLSPGDPTRLFQVFLGDGQHSFAAHGLGGSSLINAGVFLKADRRTLQMSPWPSEIRDQPSALDEHYARAETMLQPSTYPDDLSPNKLKHLQEELRWLGKRNNFYRVPLTIFFHNGCNNAGVPMQANRQSGHECTGLNDGSKNSVATTYLADAWNWGAEIFCGCEVRFVENMDGGGYTIHFAWHGSGRSVFADHFKEQLFWVKAKEFCFLGAGALGTTEVLLRSKQHGLHMSPLVGRNLSGNGDFLIFGYNGYANINGIAGESSRAPPGTTVTAVIDNRVVDPLDNPLSGYVIQDGCIPAMFNPVIQIMLTLQTMKSQALCCLWNPRQEAKKTLASLKSLLFGPYAYNGALQRTSTYLVMSHDSNEITLILKDDRLYLRGPGEGRSEHFKWIKNLFNESFARTGSRMGFSYFYAKGRHQEETTVHLLGGANMSNDGTGHGGVTNHLGEVFSGSNGEVYKGLVCCDASIIPTALGVNPLGTISALSERSVSLITERSGLSIDIETENQTLNAYCKPSISCDFQDHQDSTEKTSQSIGWKFTETMHGHISMRSDNGSFALSERVGKGSSCAMRMFLTIEICRDSQYQGICTGTISCYALSRATLKIVEGTVDFFTPIEENAESSAISYHLKLLSVEGIEYRLKGHKLINTNMAFSARKTWEATTTVNVNITRLDGTTIGAGALHISLLDFQKQMRTFRTTKDFQISLILALVWFLVSFIYHISLFFVRPFVRMRFPQISTKGTDVKQPPSTSCNVTASDGVQIHLDIYDPLPAQKTDEPGPNCNLAPVLLLPGVTGIGAMHNLYSLPFLRCNMVEYLTQRGHRCYALTPRWGCDPAVAQKSTVFDCRLDVAAAIAYIRDKERQKPYVVAHCQGSVALCMGLLDGTIQSSQLLGVTANSVFMNQVFGYWNSLKGRTTLLIQFYELLAGNYFPIVSSAKSVLLQRLLDTLLRLYPVGHTRDICTSTACHRTSFAFGLLWNHENLDMSLHDNVHQFFAGTHTKLMKHVVRMGTRGICMDNDSCPLLTDENLQRLQGLPILFVSGTENQVFSPESTLKDYELLRRRFGERLYRRFLVEGYGHLDPIVGKDAAEDVYWRIFAHLRWCTKEAESTNLRAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W6QLX5</accession>
    <name>W6QLX5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DNA helicase, UvrD/REP type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PROQFM164_S06g000417</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792020">
        <property type="protein sequence ID" value="CDM37455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1365484.W6QLX5"/>
    <dbReference type="OMA" id="SFASWVM"/>
    <dbReference type="OrthoDB" id="3156807at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039904">
        <property type="entry name" value="TRANK1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21529">
        <property type="entry name" value="MAMMARY TURMOR VIRUS RECEPTOR HOMOLOG 1, 2 MTVR1, 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21529:SF4">
        <property type="entry name" value="TPR AND ANKYRIN REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00580">
        <property type="entry name" value="UvrD-helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5 7" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="6">
        <location>
            <begin position="534"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="555"/>
            <end position="562"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM37455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="2169" mass="246085" checksum="7AFF0393B75D08B9" modified="2014-04-16" version="1">MASVQTPWTSILLQEKPGLHEYNHALSNVEKYYTRLQRAMQDESIHDQLVLNPDQTHSRLLKSFEILRTKQLPGPVAEEIFKTMVLPFIHDNIFSPPQMIQLVGSALPLITKQHSQFLRDLASTLLSSQGLFDHLVANENYTVILKEWLFSKRTRLSLALSTQVGDRLVAMCNACSADHGTEATVESWGIAQELMESINALIDSSYEEELKRAKVENLPPLESMKVLSRDDKKSTLVQQGPKKELKKEFTVSDEILQQMDHFNILPPLSARGLTHAVEHLQNEIIPALMRSALESFPCRTCLDRLTTGSLTGTLANSTDLPSDRTTAPGNAQDIFGKRVGLWKVLLSDIAFKNVKKLVHGGEFGGVEQKLRDLASGEWKGKDLSHRVGSKQQKKRMQVPILEVSASATVSMLWQVDVGFYDELPWVQQQIVKVWQIVTSEEELETAIEHILLIQETYTSELVKLCLERPIQQSDGTWTPQRFGNVKETGSYRMKSVASSKASPALIEMSNKFYNLTEPFLKSIIDENDTEEFPFDLSPEELEIVKHFSTSTLILGRSGTGKTTCLLFKMLAKHKARQSASDGQQARQLLLTRSSYLASKLQTYAKSLIDAQSKAPSTEEDVDSDLRPTSFFALKNWHFPVVCTYDEFLGLLENTIRMADRKDFLRDINPNKTKGLEVQGGDKPRIIDFSIFKTEYWGSLSGLAPPSCSPELLFAEIMGVIKGSTVTAKSLKPLYRAEYVKKNAKASPAFTSEAEREKVFGAFERYEKQKKLRKEIDELDRVGTLLKSLRDNKALAEQIQRCFEEIYVDEIQDLRCLDIVLLLGCLSDARGIHLAGDTAQCISKDSVFRFPEIKALFYEHYEIIANELNQPSFAKPVQFSLAKNYRSHQGILSFASWVMQLLWHGFPETIDKLDPEIGYIGGPKPIIFAGFDSSILSAKMIGLVKLNDKVADFGAEQVILVRDDASKDKLQTQIGEIALVLTILESKGMEFDDVLVYDFFGSSGLGSSYRCLYMLVQASRAQFDSQKHAALCSELKSLYVAVTRARKQLWFMETQENSVDPIVQTLSQSNSLKLAEIVKQKDPNVAEKVMVLRAGGSVDPERWLKRAAHFLHQKSFAEALFSYKKANNSRGITHSQACLYEQEGRSHRAAGDTEEFTACYEKAIALFLEIGLITEAAMCYEGLGQFGKVAEIWKEREQYQKAASFYEKGNFFTEASECYHACGQYEAAIEVLRRGDQFDELVAYANRNREYLSEPTLVRYSRLCNILLKQGRVSASLRAITINMLGSDVSKIAFFKEFEMWNQLCTLYSSKSRWFEYYDLSVAVGDIPAAISTLLVHKLIPVVDKPVVEKLFSYSMVEVLYAHRDLIPSKPERDGLLKSAKSTYLEKLGAQWKSLLLLVDNFEDVDLPASVKTLDKGLVKDIFCLFVIAFEPSIFTKQKTEHLPMEIVIRVGKLLQDLHAQNQYSIKCLAMACGIFTNPKQESHTILLHWSPLRTYTATPLDGSSFQNLIDIAKNFIQEKFTAALAQFHENALSLTKRDFLPTCVHHLYKGFCPKFKTNECSWKHEKPTAEFAIAKLNCLLAIAEVFARLTPVYYQRVMGKAFNKPFLGRRRIWIQQIQEELVIVSSLEQSSIAITNLRFNLQSNPEFAATAYCLEDLLFYRMNTEWGSMNSLSSSLEKVQEAQILGPHPATRFQRALILNMDRIMPPRPRRSGHPLALPLTTLNAAERIRSAVGRRHGQDFHNGINTFIQCLEKTPKSSLGSLHAVLSVFEFAATYILYIANPGKGIVIPWSWALQHLSTIMQSPVKDYLFKDREIRVHITDLMHLVISFCNLMEQVENAFTSGALKFQGLGRTSLPIPIVKRRCTELLTTVNLNLNHWPKQPIGFKDMEKVVNKTLRSTLIPPGMALEFSNSDKFRQSCIREFAAYNHKDELCVIALDDRKSAPLFLRSFTQGNVKFIQLSDILKISRITENQLSMGLEEDWQVDEYTGYELDMITNLQRRWRQVMEVIENNRHRAQSREGKLIQHFHEVCTRRMSVLPAAAWSTRDKIHMRKVIFTEGIKIAMSLDGVLDSFRQLNDRWRQQFHSNLSTAKLEELSVIRGRVLPIDGQLEYIVEHWSLKGIEEGMMTVPAEDLGVSAREAQRALWVVQREIEIIKSQVEIIAKSPDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W6QLX6</accession>
    <name>W6QLX6_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">Altered inheritance of mitochondria protein 24, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">aim24</name>
        <name evidence="8" type="ORF">PROQFM164_S07g000161</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the AIM24 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792021">
        <property type="protein sequence ID" value="CDM37813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QLX6"/>
    <dbReference type="OMA" id="QTRCVQI"/>
    <dbReference type="OrthoDB" id="5295771at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007007">
        <property type="term" value="P:inner mitochondrial membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.160.10:FF:000001">
        <property type="entry name" value="Altered inheritance of mitochondria protein 24, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.160.10">
        <property type="entry name" value="Mitochondrial biogenesis AIM24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002838">
        <property type="entry name" value="AIM24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036983">
        <property type="entry name" value="AIM24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016031">
        <property type="entry name" value="Trp_RNA-bd_attenuator-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36959">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 24, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36959:SF2">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 24, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01987">
        <property type="entry name" value="AIM24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51219">
        <property type="entry name" value="TRAP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="326"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="326"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="341"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM37813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="403" mass="44268" checksum="A5AF84C2B15B3F59" modified="2014-04-16" version="1">MRPLQGVRPLSWTRVVPRVHRQTRCVQIRAAPSGVPSVSGDNLPLASTPSSVESRDARFDVVGAPYSLLSVSLSASQNLYTRRGTLVGLSGKADNVISTLSVLEPFRRAIVGVPFLYQKISSPSPVTALVSVRSPNTSFAVVNVNGSVDWMVAQRRALLAWTGRSLTIKPTINANLSLSHWGSSEVTGRGLIALVGNGQLYSVELKDGEQYIAHPSNVVAYTMASNPPRPYRFKSTTLNFQVPGLKTLPRLLQNAKFVRDVSDSKAYKIAMQWFHKLRTWSRMTIWGDRLFLQFDGPTTVLIQSRGPRLNDVLSAQEVNEIANVPSGFTLSPSTSAPRSTESGKEIEEKPVDERTEAEKAVSNVPGLTRSVQELENDIEGTRRSVAEIRKDGKVKFDEVSRTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W6QLY8</accession>
    <name>W6QLY8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S02g000727</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QLY8"/>
    <dbReference type="OMA" id="QVQQYWL"/>
    <dbReference type="OrthoDB" id="3827557at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39609">
        <property type="entry name" value="RFEG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39609:SF2">
        <property type="entry name" value="TRANSCRIPTION FACTOR RFEG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="77"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM30577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="120" mass="13322" checksum="F79463F91F9919CF" modified="2014-04-16" version="1">MSPVQQYWLPGYGLSRHIVLGHIQYFLGPTATVRPYSYQGREGYLINGVPLTREQIDDLAVMSREYEKQEATRMAHNTSGASTSSPSSDNPAAQSEPYINEIIPINQPGTRRPADSRGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W6QM79</accession>
    <name>W6QM79_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein BFR2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PROQFM164_S06g000051</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AATF family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792020">
        <property type="protein sequence ID" value="CDM37091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QM79"/>
    <dbReference type="STRING" id="1365484.W6QM79"/>
    <dbReference type="OMA" id="INFMAPN"/>
    <dbReference type="OrthoDB" id="5783963at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025160">
        <property type="entry name" value="AATF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039223">
        <property type="entry name" value="AATF/Bfr2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012617">
        <property type="entry name" value="AATF_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15565">
        <property type="entry name" value="AATF PROTEIN APOPTOSIS ANTAGONIZING TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15565:SF0">
        <property type="entry name" value="PROTEIN AATF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13339">
        <property type="entry name" value="AATF-Che1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08164">
        <property type="entry name" value="TRAUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AATF leucine zipper-containing" evidence="5">
        <location>
            <begin position="193"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="Apoptosis-antagonizing transcription factor C-terminal" evidence="4">
        <location>
            <begin position="390"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="280"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="330"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="487"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="98"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="115"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="144"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="492"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDM37091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="516" mass="56316" checksum="97C2A5CC8A6451AB" modified="2014-04-16" version="1">MGKPRAGRSLADQLADFEDPTPKDFDPEDIDNGQQSSDEEGEDKEEVTAGREHYETVGKAKLRKDDPLPLGKQYDGARVSRAALGAESDEGDENTDVSSGSEESASGDDALAQESSDEDTEGGEDDDDEESEEDDEDDEDADEVVDKHSKKTLQDVRHGDTSGPSVDRDEIRKLMATDQKTIAATISSAAKADATKGKAVKQQRTTFDALLNARMKLQSGLTSINGIAAVLGSKNEADGENEMNQEEEVVDEEAIKSAESAALALWSTLEGLRTALADATAKEGSKKRKRPSPASPTTSSTSLWERMAELESQSISHRRSILDKWSSKVRGTSASLPNARGKLLGSTSGRQQTITAVLDAQVATEIGERSSKRSRTSDQQEPLYDDGAFYQSLLRDLVEQRMSSADSMTSGFDNLHQLPSRLPIHPITGMRNDKVKRDIDTRASKGRKMKYTVHEKLQNFMAPDDRGSWSTRARDEFFASLLGKTASGLLGEGDEDISDEEDDVDREEGGLRLFRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>W6QN29</accession>
    <name>W6QN29_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">biotin synthase</fullName>
            <ecNumber evidence="3">2.8.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">BIO2</name>
        <name evidence="18" type="ORF">PROQFM164_S06g000317</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">FM164</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="15">Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="15">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; biotin biosynthesis; biotin from 7,8-diaminononanoate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the radical SAM superfamily. Biotin synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.6" evidence="3"/>
    <dbReference type="EMBL" id="HG792020">
        <property type="protein sequence ID" value="CDM37356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QN29"/>
    <dbReference type="STRING" id="1365484.W6QN29"/>
    <dbReference type="OMA" id="NICTTHT"/>
    <dbReference type="OrthoDB" id="2414104at2759"/>
    <dbReference type="UniPathway" id="UPA00078">
        <property type="reaction ID" value="UER00162"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004076">
        <property type="term" value="F:biotin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009102">
        <property type="term" value="P:biotin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000011">
        <property type="entry name" value="Biotin synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01694">
        <property type="entry name" value="BioB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010722">
        <property type="entry name" value="BATS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002684">
        <property type="entry name" value="Biotin_synth/BioAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024177">
        <property type="entry name" value="Biotin_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaA/NifB-like_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00433">
        <property type="entry name" value="bioB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22976">
        <property type="entry name" value="BIOTIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22976:SF2">
        <property type="entry name" value="BIOTIN SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06968">
        <property type="entry name" value="BATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001619">
        <property type="entry name" value="Biotin_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01060">
        <property type="entry name" value="BATS_domain_containing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00272">
        <property type="entry name" value="biotin_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01278">
        <property type="entry name" value="biotin_synthase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00876">
        <property type="entry name" value="BATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 15" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="4 15" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="9" id="KW-0093">Biotin biosynthesis</keyword>
    <keyword evidence="11 15" id="KW-0408">Iron</keyword>
    <keyword evidence="12 15" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 15" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Radical SAM core" evidence="17">
        <location>
            <begin position="79"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="362"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="303"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR001619-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CDM37356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="389" mass="42076" checksum="CB0C134B7FE49A63" modified="2014-04-16" version="1">MSLPIRSLSRALVRSYGTVQGSPSAASLTSIPLTLTDATGATGPRTNWTLDEVKQIYETPLSQLTYAAAAVHRRFHDPAAIQMCTLMNIKTGGCSEDCSYCAQSSKHNTGLKATKMSPVDDVLAKARNAKANGSTRFCMGAAWRDMRGRKTSLKNVKQMISGIREMNMEVCVTLGMIDGDQAKELKEAGLTAYNHNLDTSREFYPTIITTRSYDERLKTLSHVRDAGINVCSGGILGLGESDGDRISLLHTVSSLPAHPESFPVNALVPIPGTPLGDRKMIPFDRLLRTVATARIVMPSTIVRLAAGRIALTEEQQIACFQAGANAIFTGEKMLTTDCSGWDEDRAMFDRWGYYPMKSFEKPEPKADATAPTPLPVHSEATSAPVAASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W6QN32</accession>
    <name>W6QN32_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Phosphatidic acid phosphatase type 2/haloperoxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PROQFM164_S02g001212</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the type 2 lipid phosphate phosphatase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QN32"/>
    <dbReference type="STRING" id="1365484.W6QN32"/>
    <dbReference type="OMA" id="ADDCPCY"/>
    <dbReference type="OrthoDB" id="301434at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042392">
        <property type="term" value="F:sphingosine-1-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03388">
        <property type="entry name" value="PAP2_SPPase1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14969:SF28">
        <property type="entry name" value="DIHYDROSPHINGOSINE 1-PHOSPHATE PHOSPHATASE LCB3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14969">
        <property type="entry name" value="SPHINGOSINE-1-PHOSPHATE PHOSPHOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="193"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="293"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="493"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="10">
        <location>
            <begin position="90"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="399"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDM31062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="523" mass="58265" checksum="3993C6CECF38DED0" modified="2014-04-16" version="1">MGTSKKDQPDAGLKSLNHYSNRLPLWRYWPRQKLIPLIRYETPYLAWVQEKVRTPTLDSYFAFTANLGTHTFFMVFLPFLFWCGSPSMGRGLVHILASGVFWSGFLKDLLCLPRPLSPPLQRITMSGSAALEYGFPSTHSTNAVSVAVYALALLGSPDSTLGTQVTLLLQAVTYVYVVSIVLGRLYCGMHGMLDCVVGCAMGAAIGLIQFHYGPAFEEFILSASPKEISLLGLLIIFLVRIHPEPADDCPCFDDSVAFAGVMLGVDVSSWHFADIWVGYPSGSIPYDLATVGWIKTVIRLFMGVLCVFAWRIATKPALLRILPPIFRTLEKLGLLLPRRFFTTASKYTTVPYNLKDHDVFPNFSDIPDILTTMRHPRRRAISIGPQSEADAYETLAYREKRRRQSQSGSNHPSPVAEDQNKLNGTPVRPRKTASLDDYEDMMGRGSPMSSAANVNFDIPTTPFPSLDIQAGERDEQEVFSQIKKPRVRYDVEVVTKLVVYAGIPWVVIEVAPLLFDLIGLGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W6QN96</accession>
    <name>W6QN96_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S11g000061</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792025">
        <property type="protein sequence ID" value="CDM38358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QN96"/>
    <dbReference type="STRING" id="1365484.W6QN96"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35587:SF6">
        <property type="entry name" value="BZIP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35587">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM38358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="150" mass="17304" checksum="3FABF138F1472A6D" modified="2014-04-16" version="1">MATSEKPKEQQKKLPVQDDDADDEDYYSSDSYTNEEYEDEAPQTKNMQVLQQRRRPLQQQKDDEYMDGDENSPEEYDEYDDDYSDDDGQAMQPFTNQVSKEKPGGGMEISHEGDKSILDEKGLKLRLELDLDIEIELKASIHGDITLSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>W6QNJ6</accession>
    <name>W6QNJ6_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 12">FACT complex subunit POB3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">pob3</name>
        <name evidence="15" type="ORF">PROQFM164_S04g000570</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 12">Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Forms a stable heterodimer with SPT16. The SPT16-POB3 dimer weakly associates with multiple molecules of NHP6 to form the FACT complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 12">Belongs to the SSRP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QNJ6"/>
    <dbReference type="STRING" id="1365484.W6QNJ6"/>
    <dbReference type="OMA" id="QVVTKIF"/>
    <dbReference type="OrthoDB" id="498543at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035101">
        <property type="term" value="C:FACT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13230">
        <property type="entry name" value="PH1_SSRP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13231">
        <property type="entry name" value="PH2_SSRP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13229">
        <property type="entry name" value="PH_TFIIH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.220:FF:000003">
        <property type="entry name" value="FACT complex subunit POB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000146">
        <property type="entry name" value="FACT complex subunit POB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000310">
        <property type="entry name" value="FACT complex subunit POB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.150:FF:000001">
        <property type="entry name" value="Fact complex subunit ssrp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.220">
        <property type="entry name" value="Structure-specific recognition protein (SSRP1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013719">
        <property type="entry name" value="RTT106/SPT16-like_middle_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050454">
        <property type="entry name" value="RTT106/SSRP1_HistChap/FACT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048993">
        <property type="entry name" value="SSRP1-like_PH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000969">
        <property type="entry name" value="SSRP1/POB3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035417">
        <property type="entry name" value="SSRP1/POB3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024954">
        <property type="entry name" value="SSRP1_DD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038167">
        <property type="entry name" value="SSRP1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45849">
        <property type="entry name" value="FACT COMPLEX SUBUNIT SSRP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45849:SF1">
        <property type="entry name" value="FACT COMPLEX SUBUNIT SSRP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21103">
        <property type="entry name" value="PH1_SSRP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17292">
        <property type="entry name" value="POB3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08512">
        <property type="entry name" value="Rttp106-like_middle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03531">
        <property type="entry name" value="SSrecog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00887">
        <property type="entry name" value="SSRCOGNITION"/>
    </dbReference>
    <dbReference type="SMART" id="SM01287">
        <property type="entry name" value="Rtt106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 12" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5 12" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8 12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4 12" id="KW-0235">DNA replication</keyword>
    <keyword evidence="9 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="6 12" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone chaperone RTT106/FACT complex subunit SPT16-like middle" evidence="14">
        <location>
            <begin position="450"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="266"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="562"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="272"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="567"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="577"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="594"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="620"/>
            <end position="629"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00063925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU364013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CDM35689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="637" mass="70825" checksum="7DF8F6D50D839998" modified="2014-04-16" version="1">MSSVASGIDANLFWLKWPPYGAPQRELQKPKSQSFQPNSTSTLNYLSHLLSSHFTPLFSAFYPLNCCNFTYTSSIMESFDNIYLDLSKQPGKCKLAESGLGWRPSGGGDTFTLDSSNIGAAQWSRAAKGFELKILSRSSGVIQLDGFDQEDLERLSKAFKIWYGINVETREHALRGWNWGKAEFTKAELAFNVQNRPAFEIPYSEISNTNLAGRNEVAVEFALPTGDGNDAVTKPGSTKNRGRKAAAGPDELVEMRFYIPGTAVKNDKAEGAEGEEEDNEEEAEEQNAANLFYETLMDKAEIGDVAGDTFATFLDVLHLTPRGRFDIDMYESSFRLRGKTYDYKIQYSAIKKFFLLPKNDDTHTLIVLGLDPPLRQGQTRYPFLVMQLKLDEEISLEMNMTEDILKGQYKDRLQAHYEEPIHQVVTKVFRGLSGKKVIMPSKDFSSHHGHQGVKCSIKANEGLLYFLDKSLMFVPKPATYIQMENIAIVTMSRVGGAVSASRTFDITVSLKGGLGEHQFSNINREEQKSLEDFFKAKNIRIKNEMAEEAAGLIAAALDNDAMGSSDDEVRPDRGSADEDESSVDEDFAGSSESDVAEEFDSDHESSGDSDEEMGDASDGGDDKPEDERPKKKTKTAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W6QPT7</accession>
    <name>W6QPT7_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S12g000039</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792026">
        <property type="protein sequence ID" value="CDM38430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QPT7"/>
    <dbReference type="STRING" id="1365484.W6QPT7"/>
    <dbReference type="OrthoDB" id="4323916at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="260"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="298"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM38430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="314" mass="35527" checksum="87D65071626A3AA0" modified="2014-04-16" version="1">MDAPNNSRDQEMEGVQGPSELPILNDKNNSPETSCQVPPLFPPSQQETERRPTLATEPFQAISKVLANLERDDPKLAFLARLVGLYQRLWESCVSKHIDGEKLERDNVLLKQTGMQLRAQREGLQLRHDKQLSRLRFFEQALESSRDRLTSLIDDWNHPCTLNLPASQEDIAKLLRLQEEWETTRQCMHICSKAGTHLDENASTIDNYATGDAIQFMVSTNEKIIHGRNRGLGWRTRQVGGHLSDAPLQQLSKNMTRVNFANTDHRGSPSAGQDEGLEDKPLSEFKDRYGRGFKLTTERSAPNVSSTTPPKSEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>W6QQC9</accession>
    <name>W6QQC9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Small-subunit processome, Utp12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PROQFM164_S02g001883</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the WD repeat WDR3/UTP12 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QQC9"/>
    <dbReference type="STRING" id="1365484.W6QQC9"/>
    <dbReference type="OMA" id="MNIPLTC"/>
    <dbReference type="OrthoDB" id="407922at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034388">
        <property type="term" value="C:Pwp2p-containing subcomplex of 90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000157">
        <property type="entry name" value="WD repeat domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000178">
        <property type="entry name" value="WD repeat domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007148">
        <property type="entry name" value="SSU_processome_Utp12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051570">
        <property type="entry name" value="TBC1_cilium_biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19853">
        <property type="entry name" value="WD REPEAT CONTAINING PROTEIN 3 WDR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19853:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25173">
        <property type="entry name" value="Beta-prop_WDR3_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25172">
        <property type="entry name" value="Beta-prop_WDR3_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04003">
        <property type="entry name" value="Utp12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117289">
        <property type="entry name" value="Nucleoporin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="83"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="110"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="177"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="279"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="414"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="495"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="594"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="636"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="683"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="domain" description="Small-subunit processome Utp12" evidence="8">
        <location>
            <begin position="818"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="308"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="739"/>
            <end position="759"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM31732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="955" mass="106508" checksum="3E0E731F2B7E4DE9" modified="2014-04-16" version="1">MVKSYFKFEHSNTFGLIASASSNAVWAKDDQIGIARQTGAGRAIVGAGEEVLCWDVKKGELLGRWRDSACRAQVSVITQSMTDEDIFAVGYEDGSIRLWDSRTATVIISFNGHKSAVTKLAFDNAGVRLASGSKDTDIILWDLITETGLFRLRGHTDQITSLHFLFPSPELLTASGLNEHSGFLLTTGKDALIKVWDLASQHCIETHVAQSNGECWSLGLSPDQGGCITAGNDGELRVWSIDEAAMMEISKEKLGADGRRILTERGTFYRHGKDRTIGIRFHPRSDYVAFHGSDKSVEVWRIRSQSEVQKSMARKKKRRKEKEARTEENAPEEDNDKPEDVSAAPVSEVFVQHVIVRTGGKVRSFDWMTNKSSGLNLLAATTNNQLEAYNIVPANKKNTDSEDPDYTRSLAVDIPGHRTDIRSIALSSDDRMLASASNGTLKIWNVRTESCLRTLECGYSLCSAFLPGDKIVVVGNKNGELEVFDIASSTLLDTIKAHDGPVWSLHVHPDGKSMVSGSADKTAKFWNFQVVQEEIPGTKRTTPRLKLAHTRTLKVNDDILNIRFSPDARLLAVSLLDNTVKVFFVDSLKLFLNLYGHKLPVLSMDISHDSKLIVTCSADKTVRLWGLDFGDCHKAFLAHEDSIMAVAFVPHNKDGNGHNFFSASKDRIIKYWDGDKFEQIQRLVGHHGEIWALAMSRTGDFIVSASHDKSIRIWQQTDEPLFLEEEREKEMEEAYDSTLTASLEQEDGEDGEKAEAVDAGKQTTGTLMAGEKIMEALELGLEDLEVVRDWRKVKAANPNAAAPDRNPVYLALNNVSAEQHVLNTVQKIPAAALQDALLVLPFSKLPALFTFLNIWADREWNVPLTCRVLFFILKTHHRQIVASKMMRPMLDSIRVSLRRVLARQKDEMGFNLSALQFIGNQIREQSVTDYIDEDTWEEQQASKGTGKKRQFVSVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W6QQF8</accession>
    <name>W6QQF8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S02g001893</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QQF8"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012587806" evidence="2">
        <location>
            <begin position="16"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM31742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="68" mass="7527" checksum="B9C274B2154B8F62" modified="2014-04-16" version="1">MAILSMIIAFIPVCAIHVPAMSLRWIVSGVLFHERRTYPAGPAPTMRTSVLSELCVILRLDLKFTKSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W6QR37</accession>
    <name>W6QR37_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S05g000367</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QR37"/>
    <dbReference type="STRING" id="1365484.W6QR37"/>
    <dbReference type="OMA" id="PSCQINE"/>
    <dbReference type="OrthoDB" id="4367900at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM36534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="198" mass="22439" checksum="1266262D29BC2C0A" modified="2014-04-16" version="1">MRVCLSSKYLFSPIPVFYNLDSDELWNPNGSMDSPASPSQSGRANKRKREPPDQFFIPVDMPGRSEQVLDSLKRASRGKTSTIPAGAACSLTSNMSQILQSHPSLKSSSAVDLLDLYLCLWECYTIKSAGKIRLEEERRFLQNSNEWLVRENEKLQQCCNHQELLLWDHHQAFVSVHQGVLGTLQNSDRPSCQINELQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W6QRC0</accession>
    <name>W6QRC0_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S02g002243</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QRC0"/>
    <dbReference type="STRING" id="1365484.W6QRC0"/>
    <dbReference type="OMA" id="WPMGTVE"/>
    <dbReference type="OrthoDB" id="10261782at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038921">
        <property type="entry name" value="YOR389W-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35204:SF1">
        <property type="entry name" value="ENTEROTOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35204">
        <property type="entry name" value="YALI0A21131P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004880417" evidence="2">
        <location>
            <begin position="22"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM32092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="563" mass="61979" checksum="E6BB3A6BAE4B4D2B" modified="2014-04-16" version="1">MRPQSLLPILGVLALSNALSAAPKNVSISNENHIFNVIQDSMRQWGSSLHHNGVSFFLAAVPAGTQFYHGTSKASPVNGTEWLAFEPEHAMVFARPRRGPPPHLPPSDDDPEPEDGSHGELRKREHHGPPAGRPPKIFDENESGYLHTYAAAKDLRLLYLDGMSAAKTSKGTLDSQDTVLFNSSFEEPPRGGGQEYERARLACEMAENEWEGRIDGVLRMEAGFEIILCNFERDLTTVRITQVKEDTEEHRGLRGNREHGDRDGPRREGDDKHHDGHGGRKDDDGRRHGPGGPGGPRGPGGPGGPGGPGGPPHGGPGNGPDSSRWMRAITARYNGIGGNRVSLNFNHFVTAFSYDVELFQDNSTLPRLAYLSPEERAAIRAEVTNLVLTHRPADVSEDWQAITDMIVTRYGDELSYFASGWIHSIERLQSEIERLLSPFIDYSARDDVAEIERCATQFLPPLSLKSGSIAAHAVHGVAQRICSSLIEAGKEKELDSAVQVLRDLIGYLDWATWKECRGCAANEICVVPIWPMGTIEDYDSPKCKDASNPYDHRGESYWGGMHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W6QSS6</accession>
    <name>W6QSS6_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Meiosis specific protein SPO22</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S06g000115</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792020">
        <property type="protein sequence ID" value="CDM37154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QSS6"/>
    <dbReference type="OMA" id="QEGTKLW"/>
    <dbReference type="OrthoDB" id="65716at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090173">
        <property type="term" value="P:regulation of synaptonemal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039057">
        <property type="entry name" value="Spo22/ZIP4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013940">
        <property type="entry name" value="Spo22/ZIP4/TEX11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40375">
        <property type="entry name" value="SPORULATION-SPECIFIC PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40375:SF2">
        <property type="entry name" value="SPORULATION-SPECIFIC PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08631">
        <property type="entry name" value="SPO22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0469">Meiosis</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM37154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="350" mass="39402" checksum="12667EF055A3629F" modified="2014-04-16" version="1">MAQPSRLHPALAGHAHTLHIALSTVGTSSPLLPPNAISRLDRWLKRNPFVVMANTSSRQQLDMVGTLLWNDCTHLISLRGQNPEDMLILGKVRAFAFVVLNMAVMPDLLGDLRALDLAVKAARICIVNQQSEIAVNILSVAATRLSNIQPAHLGLDAAINRTITTQYLLLRMRLAWLHERADIAEHFYGKLPVLHRSHDEEWIFETCFIIGDSALARRLPDIAITWLQRASDHLQSLHMMIKFPYYYDWDLVIRHSLVVACSQVKIPLATAIYDFEMSYLRENYPFHPAVILFDLSMGHGNPSNDGALQALERLVDGMTLTDMNMPIIFQYARSLGHIGYLDTPIGERLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W6QT41</accession>
    <name>W6QT41_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S06g000205</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792020">
        <property type="protein sequence ID" value="CDM37244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QT41"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM37244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="56" mass="5955" checksum="3FBAA9AA301198F2" modified="2014-04-16" version="1">MTSQSKSALITAIAGEYDHPISLSSCAPPHKVKVDRHAIRGDGRLAIYACKYVGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W6QT50</accession>
    <name>W6QT50_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S06g000220</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792020">
        <property type="protein sequence ID" value="CDM37259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QT50"/>
    <dbReference type="STRING" id="1365484.W6QT50"/>
    <dbReference type="OrthoDB" id="4227485at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM37259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="130" mass="15054" checksum="D67DCA0E6E559637" modified="2014-04-16" version="1">MEASENLLGHRTNSLALHRLKYYEGCAIIKLQYLRFETDNLTGTRQIAEKNVEKLLRMFEIEGCGNLEPEHRVAATIDYVLRKAHDAVNIPVLYILVIIPIPFYTVALHEYSHPSTSIFDRPFLPPAYYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W6QV72</accession>
    <name>W6QV72_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S08g000085</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792022">
        <property type="protein sequence ID" value="CDM38034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QV72"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM38034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="34" mass="3728" checksum="7467115E5F111F2B" modified="2014-04-16" version="1">MDRYYMLHTWLVTPPSPRLTARPPSSSPGALGGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W6QW41</accession>
    <name>W6QW41_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Amidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S11g000037</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the amidase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792025">
        <property type="protein sequence ID" value="CDM38334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QW41"/>
    <dbReference type="STRING" id="1365484.W6QW41"/>
    <dbReference type="OMA" id="PGWHIDG"/>
    <dbReference type="OrthoDB" id="421993at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000120">
        <property type="entry name" value="Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895:SF67">
        <property type="entry name" value="AMIDASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895">
        <property type="entry name" value="TRANSAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="3">
        <location>
            <begin position="150"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="567"/>
            <end position="588"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM38334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="610" mass="65680" checksum="2BDB8C99E9B13E6E" modified="2014-04-16" version="1">MPVNEQSFLNYPPTLEGPNVPYKYEDQVLPVFRGVPLAIGATLIHNIGFIQSHFWRNAGFGVIREIPHLGQYAGRYDPTVIPVDNTTQAEAEAKAASAVVERRKGDHGYYTSADYRALYLSGELTPTAVVETLLPLIRRDIQPSGKHSVAFLESQVELIRAAAEESTERYKKGESLGPLDGVPVAVKDEVHLTGYKRTLGSKLDFKHGTDATSWCVKQWLDAGAIIIGKTSMHEIGLDTTNNNPNYGTPRNPHNKEYYCGGSSGGSGYAVAAGLIPIALGADGGGSIRIPSSFCGIWGLKPSHGRVSGAPSQSLAPSVGVIGPMAASIDDLALAYRIMATPAPASEDPISSQFPYPVPPDSDVKRTKTIGIVRDWIDRAEGPVRAALDRALDYYREQGYNIIDITIPYLPEGQRAHALTIMAEIASGVDASKIRQLTAPNKVLVSMGMYQVTAQDLLASQRLRNLLMTHLAHLFKTHPGLLIVSPTTPIPGWHIDGGEADLSRGLSDAGSSVRNMEYVWLANFTGCPAISCPVDYTPGGVPIGVMAMSEWGTEEELIAFARDGEPILDLPSSSSPEESEIASATKGLRTPSDDLSVWEDIIAQAKEKISN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W6QWD1</accession>
    <name>W6QWD1_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S03</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S03g000536</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QWD1"/>
    <dbReference type="STRING" id="1365484.W6QWD1"/>
    <dbReference type="OMA" id="CSMMFPK"/>
    <dbReference type="OrthoDB" id="5352472at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM33812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="340" mass="37592" checksum="D2697ACC4C6514BF" modified="2014-04-16" version="1">MQTILLPSSAAAFAPRSSPNVVLNTKVEPWLTATLKRVNRVKRPLNNVTQHTRCLTETLSSKNAIWTLCSMMFTKAPQAELEKNENQLWESLHSHQMIHMEAYVVHVDMVSRNEVVFKLTPETIESLVDFHKDVYSVDAAANTYDWPGKHGELKRLQEEFVQAANKFVYRANAQALEGLEEDGAGELLSGRSDEAKAAIGKLFIPLVAPSPPVVDVMRPIPLLPSSTGPENWWQNPVPQQAPLESWKVLLSFSDAQLASPTPSYSQPFTPSPFQTYNCLPTTCMPTTCMPTTSAAISPLPLPTMFPSIFPSMLVQPCSTAFNMGGFSWADFAPLPYGTIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W6QXL1</accession>
    <name>W6QXL1_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Genomic scaffold, ProqFM164S03</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S03g000986</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QXL1"/>
    <dbReference type="OMA" id="GWICMVT"/>
    <dbReference type="OrthoDB" id="405906at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056120">
        <property type="entry name" value="DUF7703"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37013:SF6">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37013">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_1G05950)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24802">
        <property type="entry name" value="DUF7703"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="53"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="82"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="159"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="197"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7703" evidence="3">
        <location>
            <begin position="24"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="326"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="292"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM34262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="359" mass="40308" checksum="B69A496FF05DFC91" modified="2014-04-16" version="1">MDTSMSNLPVEVSLILNTNFTIVQVIAMFSIGAWNSLEVVICIFERFKKYRGLYFWSMQVAAWGILLHAIPAQIRYTQQASAIAMSVPFMVGWICMVTGQALVLYSRLHLVVADIRHVRWVLWMIITNFFILHIPMAVLFGLNVGNIPCGPVSGIYDRLQATGFAIQDTIICAIYVREALRALKPVFESKGPQGRRIIYRILFVNLFGILLNVLILLAEYKVHYIVISFKTVAYSIKLKLEFHALTQLRELTRTYPCAFCQGANGNARRSTDINLFDMLANSLPSQDTEAQASSSAGTAGRTASPEQHSARSGIYDFHEAMRQTMSTMDIVESRANARPRLPSSDTQSSIEMALIERPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>W6R175</accession>
    <name>W6R175_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Mitochondrial carrier domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PROQFM164_S04g000463</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6R175"/>
    <dbReference type="STRING" id="1365484.W6R175"/>
    <dbReference type="OMA" id="QFMMYEL"/>
    <dbReference type="OrthoDB" id="2019556at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015217">
        <property type="term" value="F:ADP transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080122">
        <property type="term" value="F:AMP transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005347">
        <property type="term" value="F:ATP transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015228">
        <property type="term" value="F:coenzyme A transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015230">
        <property type="term" value="F:FAD transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044610">
        <property type="term" value="F:FMN transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051724">
        <property type="term" value="F:NAD transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000134">
        <property type="entry name" value="Peroxisomal membrane protein PMP47B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052217">
        <property type="entry name" value="Mito/Peroxisomal_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45939:SF5">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PMP34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45939">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PMP34-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10 12" id="KW-0472">Membrane</keyword>
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    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
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    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="22"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="226"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="19"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="119"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="224"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDM35582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="318" mass="34566" checksum="E513441C8E7D9AB2" modified="2014-04-16" version="1">MSQPGAEQSKAASAAVQQSDNIAHALAGAGGGVLSMVLTYPLITLSTRAQVESKRAHSTTLDAIRRIVQREGISGLYSGLESALFGISVTNFVYYYWYEFTRSAFEKAAIKGGRASKKLTTVESMIAGAIAGSATVLITNPIWVINTRMTARKSEAEATLPGAKKTKASTFSTLIDLLRQEGPKALFAGVLPALILVINPILQYTIFEQLKNIVERRRRMTPKDAFYLGALGKILATSLTYPYITIKSRAHVASRDGPKESLNGSLKRIIQEEGWKGLYKGIGPKVTQSAITAAFLFAFKDVLYDLMVSARRRGRIAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W6R334</accession>
    <name>W6R334_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S05g000065</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6R334"/>
    <dbReference type="OrthoDB" id="5401170at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM36232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="111" mass="12962" checksum="BA408BF4AB130919" modified="2014-04-16" version="1">MVPALLAHKEGKQGKDGVALDGYITHIVWEMVRRSHEVPPYLGRVEASWMASIAPSFAEYYIRVNRRHIAGFRDPDRFDLDEEFSDMTFVLWRSTRPPRKSGWEKDPTKWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W6R3E5</accession>
    <name>W6R3E5_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Concanavalin A-like lectin/glucanase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S05g000150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792019">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1365484.W6R3E5"/>
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    <dbReference type="OrthoDB" id="42525at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009784">
        <property type="entry name" value="DUF1349"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35332">
        <property type="entry name" value="REGULATION OF ENOLASE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35332:SF2">
        <property type="entry name" value="REGULATION OF ENOLASE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07081">
        <property type="entry name" value="DUF1349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM36317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="197" mass="21746" checksum="7B4CDD14117CA5AE" modified="2014-04-16" version="1">MSQSQFKFANSDAEVPGKGVLPAEFTIKTPASTDIWAKPPSTISFSAPILYKSVPLKSFKRIRVAVTGLWEKKYDQGGVVLVLNTAGGGQKWVKCGIELTHGKPHLSVVAKDNWADWSLLPVPSGSGSATLELVREEDNSLWIYLVEGLQKSPIREVTWIFEQENVEDFWVGIYAARPSTEGGELSVKFSHLIIDQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W6R5H6</accession>
    <name>W6R5H6_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="7">D-3-phosphoglycerate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PROQFM164_S06g000027</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792020">
        <property type="protein sequence ID" value="CDM37067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6R5H6"/>
    <dbReference type="STRING" id="1365484.W6R5H6"/>
    <dbReference type="OMA" id="KHGAWQQ"/>
    <dbReference type="OrthoDB" id="298012at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12169">
        <property type="entry name" value="PGDH_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050857">
        <property type="entry name" value="D-2-hydroxyacid_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42789">
        <property type="entry name" value="D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G10090)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42789:SF1">
        <property type="entry name" value="D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G10090)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase catalytic" evidence="5">
        <location>
            <begin position="32"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="6">
        <location>
            <begin position="121"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM37067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="343" mass="37233" checksum="1E7565512CFFAAAA" modified="2014-04-16" version="1">MAHFKFAILDDYQGIAPAYFTHLESRVDISSFPETLDPRDPAQHDALVQRLLPFDIILAMRERTPFAANTIAALPNLKLLLTTGTRNLALDLGAFTRSNVAVAGTEGRPPGVNSTVQHTWALILGLARNIARDDAAVKRGAWQGSLGINLSGKTLGLLGLGKLGSQVGKIGALAFGMKVLAWSTNLTQEKADEQAHAQGLPVGTFAVAASKEEFFAQADIVSVHSVLSDRSRGIVGATEIANMQPSAFIINTSRGPLIEEQALLEALNAGRIRGAALDVFDPEPLPLDSPWRNTPWGQDGRSEVLLSPHMGYGEEELLRGWYRETAENLERWLNGQELLRKMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W6R6A3</accession>
    <name>W6R6A3_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S06g000293</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792020">
        <property type="protein sequence ID" value="CDM37332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6R6A3"/>
    <dbReference type="STRING" id="1365484.W6R6A3"/>
    <dbReference type="OrthoDB" id="1668230at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM37332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="56" mass="6240" checksum="575F1D54A81089EC" modified="2014-04-16" version="1">MSSRFLDLSGDTILQEQVLGCGSSAVVVLRDGLAVKTPLRYIWSSDIDRYRGSDEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>W6R7V6</accession>
    <name>W6R7V6_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="20">Peptidase S8, subtilisin-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">PROQFM164_S07g000286</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S8 family. Furin subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG792021">
        <property type="protein sequence ID" value="CDM37937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6R7V6"/>
    <dbReference type="STRING" id="1365484.W6R7V6"/>
    <dbReference type="OMA" id="RCCGEIA"/>
    <dbReference type="OrthoDB" id="300641at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007323">
        <property type="term" value="P:peptide pheromone maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04059">
        <property type="entry name" value="Peptidases_S8_Protein_convertases_Kexins_Furin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000026">
        <property type="entry name" value="proprotein convertase subtilisin/kexin type 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.200:FF:000005">
        <property type="entry name" value="Proprotein convertase subtilisin/kexin type 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034182">
        <property type="entry name" value="Kexin/furin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002884">
        <property type="entry name" value="P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42884:SF14">
        <property type="entry name" value="NEUROENDOCRINE CONVERTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42884">
        <property type="entry name" value="PROPROTEIN CONVERTASE SUBTILISIN/KEXIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01483">
        <property type="entry name" value="P_proprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51829">
        <property type="entry name" value="P_HOMO_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 14 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 14 15" id="KW-0645">Protease</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 14 15" id="KW-0720">Serine protease</keyword>
    <keyword evidence="5 18" id="KW-0732">Signal</keyword>
    <keyword evidence="4 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="11" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004880426" evidence="18">
        <location>
            <begin position="20"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="724"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="domain" description="P/Homo B" evidence="19">
        <location>
            <begin position="482"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="621"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="773"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="621"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="639"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="688"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="795"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="13 14">
        <location>
            <position position="196"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="13 14">
        <location>
            <position position="234"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="13 14">
        <location>
            <position position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR615500-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CDM37937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="836" mass="91437" checksum="AD0BE7809A858BB7" modified="2014-04-16" version="1">MRIVSGITATLGLAGAVSANLHPRSQETRDFFALQLDDTTSPSHIAQILGARHEGQIGQLDGHHTFSLPREQTPQFDTLLNDLRTRRKLRRRSGAIGSSDDPLDKILWSHKIAPARQRLQKRLPPVSVPYKSLDKREDAQAVAFRKDAMSTLGITDPIFKEQWHLINTKQPGHDLNVTGLWLEGITGKGVATAVVDDGLDMDSYDLKPNYLPEGSWDFNEGLPEPRPLLLDDKHGTRCCGEIAAAKNDVCGVGVAYDSKIAGIRILSKPIDDVDEAAAINYAYQKNDIYSCSWGPIDDGATMDAPGILIKRAMVNGIQKGRGGKGSVYVFAAGNGASYGDNCNFDGYTNSIYSITVGAIDREGNHPPYSESCSAQLVVAYSSGSGAYIHTTDVGARECSAGHGGTSAAGPLAAGSVALALSARPELTWRDLQYLMVETAVPVSEDDGSWQNLPSGRKFSHDWGFGKVDTYTMVQLAKTWDLVKPQAWFNSPWLRVHQEIPQGDRGLLSHYTVTADQLKEANFAKLEHVTVTMNANHTRRGDISVELRSPAGIISYLSVAREKDVMPVGYEDWTFMSVAHWGESPIGDWSIIVKDSNVNEFTGAFIDWRLNLWGEAADGAKQELHPLPDDHDDDHPYEDAPVATTSVTAAPTKTPAPNPDDHHDRPVNAKPKPKPTTTNPTPIEDVKLPTSTTSNEAETPSASSAGSGYISSWLPTFGASKRTQIWIYASMAMIVTFFIGLGVYFQLQRVKRRRTTAHDDYEFEMIEDEDEMQPMTGASGRTQRRGGELYNAFAGESDEEMFSDDDDDQPYRDGLANIPEKDNGDGTSHGGPHLPKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W6PQ95</accession>
    <name>W6PQ95_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Extracellular membrane protein, CFEM domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PROQFM164_S01g000157</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RBT5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PQ95"/>
    <dbReference type="STRING" id="1365484.W6PQ95"/>
    <dbReference type="OMA" id="IRCINEA"/>
    <dbReference type="OrthoDB" id="4505683at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008427">
        <property type="entry name" value="Extracellular_membr_CFEM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05730">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00747">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52012">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="9" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004879159" evidence="10">
        <location>
            <begin position="19"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="CFEM" evidence="11">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="51"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDM26348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="90" mass="9454" checksum="D2A7F6337847E471" modified="2014-04-16" version="1">MKLTIFFPLAAFLSWTVADPLDDASPCLIRCLNEASAVAGCLSSIDYKCTCPSPAFKDTLGTCLKVSCTAADLTVAGELHKKRCGGSPPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W6PQM6</accession>
    <name>W6PQM6_PENRF</name>
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        <submittedName>
            <fullName evidence="3">SRP40, C-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S01g000307</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PQM6"/>
    <dbReference type="STRING" id="1365484.W6PQM6"/>
    <dbReference type="OMA" id="ENNSGME"/>
    <dbReference type="OrthoDB" id="5599646at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039191">
        <property type="entry name" value="Nopp140-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007718">
        <property type="entry name" value="Srp40_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23216">
        <property type="entry name" value="NUCLEOLAR AND COILED-BODY PHOSPHOPROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23216:SF1">
        <property type="entry name" value="NUCLEOLAR AND COILED-BODY PHOSPHOPROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05022">
        <property type="entry name" value="SRP40_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Srp40 C-terminal" evidence="2">
        <location>
            <begin position="343"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="366"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="78"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="107"/>
            <end position="123"/>
        </location>
    </feature>
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        <location>
            <begin position="124"/>
            <end position="133"/>
        </location>
    </feature>
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        <location>
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            <end position="152"/>
        </location>
    </feature>
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        <location>
            <begin position="161"/>
            <end position="175"/>
        </location>
    </feature>
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        <location>
            <begin position="188"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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            <begin position="264"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="306"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM26498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="396" mass="40568" checksum="729BF5B77CCE9F84" modified="2014-04-16" version="1">MAKASSKKTSVKKTDSSKTKSIPPQLIASVAAFLSDNFPQTSVAFTKEATKSGKQSDAKNVPSLLELFQASEQKSSVKKSASPSSSSSSSSSSDSDSDVEMGEATRSSSSSSSSSSSSSSSSDSDADDEDDDDKSPAAPTSAPSSAPAQKSAGVKRKAESSSESSSSSDSNSSSSSEDDSPKAKKAKTSPTPKEASSSSSSDSSSSDSDSSSSSSSDSSSDSSSDSSSDSSSESSSDSSSESESESESESEKESKKALKKAKKTPLPESDSSSDSESSSSGSTLAASPETETKPTKKAVETVQTTSSSASPAPGNGPAKKKHTGARPTPLALLSELPHDHPSNDYMSYAYADRAWKDLSVTRGKGFTKEKNKKKRGSYRGGPIDIAPGTTSYKFED</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W6PR23</accession>
    <name>W6PR23_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g000452</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PR23"/>
    <dbReference type="OMA" id="DGSWNQY"/>
    <dbReference type="OrthoDB" id="4148828at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="83"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM26643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="279" mass="31417" checksum="C79ED61121882142" modified="2014-04-16" version="1">MAGIVNGPLSLFRKSDSSKPLHARWGDVSISVPTDGSWNQYENPHRPVKEKSAYGPGYVPDCSPQDRNSRPVKEDDPEDDSRSVCSATSTASRRSSLSLGGLRPGRLSVRLASRPRQLRGKSQMERDAQHSEEKRNEFAYRPIQQDYNSEVVEKTTQPSNRFKYIPTNGRYIQSPGIEATRNAYSRRGSSSDLIDHRYSGRDRDQYTPAVRVSNYHEDDRRSLYPNIGDNSDSPSSQRNYGLPSRPRMSPSFAADSRRASSISKPMTLAMVPDPDNLYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W6PRP4</accession>
    <name>W6PRP4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Vps52/Sac2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PROQFM164_S01g000349</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VPS52 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PRP4"/>
    <dbReference type="STRING" id="1365484.W6PRP4"/>
    <dbReference type="OMA" id="IHVVMVE"/>
    <dbReference type="OrthoDB" id="19482at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000938">
        <property type="term" value="C:GARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007258">
        <property type="entry name" value="Vps52"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048361">
        <property type="entry name" value="Vps52_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048319">
        <property type="entry name" value="Vps52_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14190">
        <property type="entry name" value="SUPPRESSOR OF ACTIN MUTATIONS 2/VACUOLAR PROTEIN SORTING 52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14190:SF7">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 52 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20655">
        <property type="entry name" value="Vps52_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04129">
        <property type="entry name" value="Vps52_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Vps52 coiled-coil" evidence="7">
        <location>
            <begin position="163"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="Vps52 C-terminal" evidence="8">
        <location>
            <begin position="352"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="16"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="67"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM26540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="680" mass="76011" checksum="B9EAF92017100877" modified="2014-04-16" version="1">MWRDRISAQSTSSGANSRNLSPLPRRSSSQLSPSPYNSRPGVTSRSSSTSLLLTPNDSTTSLPGTARATNGSPLKQTSIQRPRPANVPDPLEVLNEIIGKEKNQTDKHVPPLSSVPERPGQLVEAIRFDGLSLEDFLKKEDPTPIKRTRESDVNAQTVQQFEQERDKFEELHTSITGCDEVSKSVELYLNDFQNELGAVSAEIETLQSRSTQLNAMLENRRNVERLLGPAVEEISISPKAVRTIVEGPIDENWVRALNEIDSRTTNIEAKAAASSNGYKAVEDVRPLLADVKTKAVQRIRDYLVSQIRAMRSPNINSQIIQQQRLVKFKDLYSYLSKVHPKLAGEISQAYINTMRWYYTSHFTRYLQALDKVKVYPPDRNEVLGGDPSTHRSGNMMPGGRAGSAVHDPFSLGRRIDVLRTGNLQALSSYLAEEDNTYHGIEVPFRNFNLALVDNVCAEYSFLTEFFSPKTFHQISRNAVEIFQPVFTLGQNQTKKLIEHTTDSLGVLMCVRLNQHSAFELQRRKVPVADSYVNGTNMQLWPRFQVIMDQHGDSLKRVGSNTSRSAVSALSIAGGDDLKQSSAPHFLTQRFGQLLHGILVLSSDAGDDEPVSNSLARLTAEFDSLLAKLSRNGTDAKRRERFLFNNYSLILTIISDTQGKLAVEQKQHLEEMLKNSTSTKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W6PSH2</accession>
    <name>W6PSH2_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Double-stranded RNA-binding-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g000599</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PSH2"/>
    <dbReference type="OMA" id="HYCATNQ"/>
    <dbReference type="OrthoDB" id="5418749at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42030">
        <property type="entry name" value="DRBM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42030:SF1">
        <property type="entry name" value="DRBM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM26790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="116" mass="12662" checksum="BB223FBD7157989C" modified="2014-04-16" version="1">MSYTTSPQGNSAGSRPSWQDQLQDHCTRTKLSPPVFNIVSDRRGGRTAWSSTVTVQGQNIAARYWYDGQFINNAKEDAAEVALKTLNQQPRAATVYQGQLFPQATSSGYGRGTGGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W6PSI5</accession>
    <name>W6PSI5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Homeodomain-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PROQFM164_S01g000614</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PSI5"/>
    <dbReference type="STRING" id="1365484.W6PSI5"/>
    <dbReference type="OMA" id="YEHHPYS"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050453">
        <property type="entry name" value="LIM_Homeobox_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24208:SF166">
        <property type="entry name" value="LIM HOMEOBOX TRANSCRIPTION FACTOR 1 ALPHA, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24208">
        <property type="entry name" value="LIM/HOMEOBOX PROTEIN LHX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 5 6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4 5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="8">
        <location>
            <begin position="190"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="192"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="30"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="139"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="158"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="177"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM26805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="534" mass="59106" checksum="59C902C13378F47D" modified="2014-04-16" version="1">MSVGGPCLWLPSLSSPVHSPLSAVSSHLSARNSERLSLGPRTISPRLSAQKKEEPAVPVPVHVPARPVEMQPTGYKAENALNNPAAQPVSMGSAPYLERDVSQDTVNHRLEAAKQDMLPRVKLEIPSLNQRGFLAVQPLVGHGGHPEEMGISSFSGSHDQRDDHDRESTISPDDDKDMMGSDDNRSPSMEKKKMKRFRLTHNQTRFLMSEFTRQAHPDAAHRERLSREIPGLTPRQVQVWFQNRRAKLKRLTTNDRERMLKSRALPDDFDTTKVLRTPFEGKQSGITPVASPQGYGVPNPDFGALRTLRTDCYARPNEDDYLVSPLSSASTAGTYMSSTGRNDSMSQSNMMFRPAASSSMSDLHRTIRNDYPVTRSSSLSDASAHPSPYAGYPMHNRFAGPQPNQPALPYMRRPIEYAMPRHPGMGPYDQHQPFEGSVSPTDTQGSHLTYDINNLGPQQQGYNLGMGSQLPPQGRPIATMQNLPVSAAQNYRPYSYDATAGPMGTPIPYTQANTSTLSLPTSEPSYNYPNYIQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W6PTU9</accession>
    <name>W6PTU9_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Biogenesis of lysosome-related organelles complex 1 subunit CNL1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">CNO-like protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PROQFM164_S01g001079</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1), a complex that is involved in endosomal cargo sorting.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the BLOC1S4 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PTU9"/>
    <dbReference type="STRING" id="1365484.W6PTU9"/>
    <dbReference type="OMA" id="RWQYLTQ"/>
    <dbReference type="OrthoDB" id="5424991at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031083">
        <property type="term" value="C:BLOC-1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034455">
        <property type="entry name" value="CNL1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39145">
        <property type="entry name" value="BIOGENESIS OF LYSOSOME-RELATED ORGANELLES COMPLEX 1 SUBUNIT CNL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39145:SF1">
        <property type="entry name" value="BIOGENESIS OF LYSOSOME-RELATED ORGANELLES COMPLEX 1 SUBUNIT CNL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="32"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="33"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="46"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM27270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="168" mass="18569" checksum="BA5386D5CD1AEE70" modified="2014-04-16" version="1">MSVSASIPDTSLGLTSSEIQILRQQQQIALQGGHAGNGVARGRGTGRTSNSSSRATSAASSQGRLLLDPMSLRALSHQLDGLQAQISHRIEYLEDQMQRSIQNTYDRAGNVIRNADAEIARTREILASIDELDNELAKIAHIRDIVKSFRGRIENLDHRIDQSSRRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W6PU95</accession>
    <name>W6PU95_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Mpv17/PMP22</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PROQFM164_S01g001135</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the peroxisomal membrane protein PXMP2/4 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PU95"/>
    <dbReference type="STRING" id="1365484.W6PU95"/>
    <dbReference type="OMA" id="ACSNMTE"/>
    <dbReference type="OrthoDB" id="10267969at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007248">
        <property type="entry name" value="Mpv17_PMP22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266:SF80">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 2, PXMP2 MPV17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04117">
        <property type="entry name" value="Mpv17_PMP22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="200"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM27326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="220" mass="24823" checksum="C270933DC5142361" modified="2014-04-16" version="1">MPSPLLVTFVQATILNAISNVLAQLIDQRNNKTPFTLNTLALLQFLAYGILIVAPNFYWQRALESRYPGFPTRAELSNAFSARSLKSLFSPRSWLSVFSRFRRDVSLPSHKDKEKHVQWVPAPTSGLHSFVMKFLFDQTAASIVNLVLFVVIINLLKGESLAKSWDLVVLDFRPLMSARLKYRPVVSVLMYTIIPVDRRVVFGSACGVIWGIYLSLYAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W6PVL4</accession>
    <name>W6PVL4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g001761</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PVL4"/>
    <dbReference type="OMA" id="FEWYPHY"/>
    <dbReference type="OrthoDB" id="5335812at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053267">
        <property type="entry name" value="Verrucosidin_biosynth-assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42087">
        <property type="entry name" value="ILP IS AN APOPTOSIS INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42087:SF1">
        <property type="entry name" value="ILP IS AN APOPTOSIS INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM27950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="218" mass="24181" checksum="34023DD6B7F4B2AC" modified="2014-04-16" version="1">MSSHPQIDPAPVIGLADASPGSDDNSDIFEWYPRYQSCQRYFLDHAQHSAPVQALSTFLNIRLPFQRQPHPIFNSTSTPSNQPSPPGTQPSGPPPISLIPYIRRLVATGMDFPGVLHGFFGDDWGSGVGPMHEQERRNYLFAAKSGGWASVKKDYDIPPLETIPFLRPLQGALDAEIEAAERSWSEWLAMEDWMVGPRAPDIMHDSSSQNSLPRSARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W6PW36</accession>
    <name>W6PW36_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Nuclear protein DGCR14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PROQFM164_S01g001936</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ESS2 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PW36"/>
    <dbReference type="STRING" id="1365484.W6PW36"/>
    <dbReference type="OMA" id="AQNDYLD"/>
    <dbReference type="OrthoDB" id="19679at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019148">
        <property type="entry name" value="Nuclear_protein_DGCR14_ESS-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12940">
        <property type="entry name" value="ES-2 PROTEIN - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12940:SF0">
        <property type="entry name" value="SPLICING FACTOR ESS-2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09751">
        <property type="entry name" value="Es2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="86"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="370"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="384"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="432"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDM28125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="491" mass="53838" checksum="8276528AD2224210" modified="2014-04-16" version="1">MASPPSQELARQSAGQLMPPPPPPKRIKRPATVLDEDVYTNTLSHIIARDFFPGLLETQIKQEYLEALESKDKAWIASSKKKLASVMRTPTPGSNARRKSDYASAPATPHHFPAGRPGDTPHGWGGDTPMSVVSTSTAATETEDRHIPDVSNMGLVAFQAKYTSEDNESFNKVLDKQNEKRREKYPWLWSGNKIPSARQIAHQQQEIKRITAQGGNPQMGLIKRDEHAQPAIKTDLDARPANPDTWKSRPDNTLMFLPNSVEDTHETLPQKAEITSRAGPKRTLYQNTRLLDPHAAAAADAANAVPPSPSLSAIQDAIAGRPRLSESEAASAFAGSETPRVNGYAFVDEDEPEPEFTYSRTDDMEADWRLLGPTSEKPNPFKLGETRKREALHHRMVDRVARNKRAEKAARVTKTPVSLTPRFGSSPRLDFGSRSTPGASSSRGSVSGGGYSQGKMLTPAAQKLLQQVGGTPRSERKSALGNVWTPTPKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W6PW38</accession>
    <name>W6PW38_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="4">pH-response regulator protein palA/RIM20</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">palA</name>
        <name evidence="4" type="ORF">PROQFM164_S01g001812</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the palA/RIM20 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PW38"/>
    <dbReference type="STRING" id="1365484.W6PW38"/>
    <dbReference type="OMA" id="VSHAEEM"/>
    <dbReference type="OrthoDB" id="64867at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09241">
        <property type="entry name" value="BRO1_ScRim20-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09236">
        <property type="entry name" value="V_AnPalA_UmRIM20_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.560">
        <property type="entry name" value="alix/aip1 in complex with the ypdl late domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.50">
        <property type="entry name" value="alix/aip1 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.280">
        <property type="entry name" value="alix/aip1 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025304">
        <property type="entry name" value="ALIX_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004328">
        <property type="entry name" value="BRO1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038499">
        <property type="entry name" value="BRO1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23030">
        <property type="entry name" value="PCD6 INTERACTING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23030:SF39">
        <property type="entry name" value="PROGRAMMED CELL DEATH 6-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13949">
        <property type="entry name" value="ALIX_LYPXL_bnd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03097">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01041">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51180">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRO1" evidence="3">
        <location>
            <begin position="4"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="740"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="742"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="805"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="830"/>
            <end position="854"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM28001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="864" mass="96328" checksum="97963D2349643713" modified="2014-04-16" version="1">MASNILQLPFRRSHPVSLSAAITQYISTKYDQRPDMFAEDLMIIDRLRTEAINVQEPHYSGISRLVTYAAQLKWLGGKFPVDVGVDFSWYPAFGFNVSRPVSQNNLRFELANIIFNLAALYSQLAYATNRTTADGLKQACNYLCSAAGVLSHLRTDIIPDLRTSPPEDMDEVTLQSLELLLLGQGQECFWQKAVKDGLKDVSIAKLAAKVSDFYGDAGDLAVKSNAISTDWIHHMTAKHHHFAAAAQFRQALDCLEKRKYGEEVARLRDCLVCVGEGLKEQRWINRTVLGDLNGLKSRVVEDLKRAEKDNDIIYINPVPPKSELKTIERASMVLAKAPSQVTDAISMLGDNGPLGQPLFSKLVPYAVHIAASIYTDRRDRLVNDTLIGELESMSDKLRDLLSSLNLPGSLQALEKPLGLPPTLVSHAEEMRQQDGLNRLHRSIDDTARVKGNDLAVYNEGVELLAAEKAEDLAARHKYGTDRWTRGTSESAAPKLYRSLTEIDGYFTSAQGSDDLVQRKLRDSRSVFLVLTGTNRDLESFVPSSRRVVIPPEVEREANRLRGCLSEVTRMENRRRRRIQALKDKGRADDIHPALLRQTARLEREFPMQPIQASQFEDLFEEHLKLYDSDREMLAQERREQDQLSDQVREANRTFTGSHKGDASTKEREAALQDLENGYLKYKEIISNLDVGRKFYNDLAKIVARFRDDAKVFVHQRRMEASQLETDISNTAAMASLHISQPHLRQQPQESPRTHHSPSAYSAAQPIHVPSQLPPPVHTVRPAETAPPLTAPQPVRAPVAPPPVSTPSMPGGMPGMWSPEMGIRFGSAANPPNATPSTGAGPAPTQPTRAPQTGTWDPSKGLRFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W6PWP9</accession>
    <name>W6PWP9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S01g002494</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PWP9"/>
    <dbReference type="OMA" id="IMAFQYD"/>
    <dbReference type="OrthoDB" id="1658288at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052374">
        <property type="entry name" value="SERAC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48182:SF3">
        <property type="entry name" value="DUF676 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48182">
        <property type="entry name" value="PROTEIN SERAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM28683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="116" mass="13477" checksum="E3150BA1B1C370A2" modified="2014-04-16" version="1">MIAPLSVVYDGVRKPEIDLVSIPGLPTIHPTYKLKDHTKWLREVLSHQVPQARIMAFQYDFAKDSMEVSWAELFRNVEYLLYSLVHRREGTEDRPVLFICYSFGAIILKKASHKLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W6PWX8</accession>
    <name>W6PWX8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acyl-CoA N-acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S01g002271</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PWX8"/>
    <dbReference type="STRING" id="1365484.W6PWX8"/>
    <dbReference type="OMA" id="AYAEDYC"/>
    <dbReference type="OrthoDB" id="5689at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050832">
        <property type="entry name" value="Bact_Acetyltransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43877:SF2">
        <property type="entry name" value="AMINOALKYLPHOSPHONATE N-ACETYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43877">
        <property type="entry name" value="AMINOALKYLPHOSPHONATE N-ACETYLTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="3">
        <location>
            <begin position="4"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM28460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="176" mass="19812" checksum="7C9DEC6445D44D84" modified="2014-04-16" version="1">MNDLNFRVATEADAPRLQQLVESAFRAEDSRKGWTDDLGLSASFRLDVQEILAMITKPDSVFLMATDDENTLVGSIGTSKRDINHAHLFMLAVDTSQQRGGVGRQVLAYAEDYSQRTWGVTTLGLNALSNRQQLISWYSRRGYKETGETSPFPREKFANLALPDDLCFVEFEKVLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W6PYA9</accession>
    <name>W6PYA9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NmrA-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g002821</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PYA9"/>
    <dbReference type="STRING" id="1365484.W6PYA9"/>
    <dbReference type="OMA" id="NGWYHEN"/>
    <dbReference type="OrthoDB" id="419598at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052718">
        <property type="entry name" value="NmrA-type_oxidoreductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47129:SF1">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47129">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="1">
        <location>
            <begin position="5"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM29010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="305" mass="34112" checksum="9863C91964D5366E" modified="2014-04-16" version="1">MTLKYLITGATGGLGAGVLSYLVANVPPSEYAAASSKEENRKQFEDRGIAFRIASYDDPQTLETAFEDVENLFFVSTNTFDIEKRRKQHQNFVEAAKKMNVWYTSLAFGGYNSDSKAAVQQGHLMTEEMMKQAGINFTSIREGLYTDAFPIFMGWYPSTSTVYLPSDGSIAFTLRSELGEANARLMIRGGHDREIVLLTAQQTITFSEIVDLINETTGRNVQIELVSPEEFVQLKTATDEGGKSEGFFQALLSWYEGISKGETGTIDPLMADVLARQPVPPLEALRAFLTENRDYEWHQNYVNRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W6PYJ0</accession>
    <name>W6PYJ0_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g003145</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PYJ0"/>
    <dbReference type="STRING" id="1365484.W6PYJ0"/>
    <dbReference type="OMA" id="LEDIWIC"/>
    <dbReference type="OrthoDB" id="4174342at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="441"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="302"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="342"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="361"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="460"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="514"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="549"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM29333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="558" mass="59931" checksum="2C584381924953E4" modified="2014-04-16" version="1">MMTATLNGVFNSSPDTPSAIYPDRLIRPLPRRTLRSRLSSDAADTLFYPPTPPASQIFYGVSADSEEAVNESKVYVQQTVDTELSPEVENHEFETPVELESGDESGPMVVRRSGVIRRSSLSPPVSGNPHSFPHDTPQTKSSTGDGYDAFENTNNKKKRKIPTPGNLGGHHSALSPEFASMGLTNSTPVRAPTPTDATGTYYGSGNPASPLGNGISGSGRGRLGRPTVRSSSRNPLSPNAQHGWLNARTPSRRDGLMPSPGPSGESSDQGIISTAIANAATLSSPPRGPGNVSLLEKEKENTTPTKTQFTFTCESDSSKGMAMQRNYSIPYRSPTSPLGPASQKQRGISTQGTQTSSMNHQAPPAQAPAQSGEPTPVGPKKKRSPSSTYALSARQRKIQQQYTNFHHPPSLEDIWICEFCEYESIFGHPPEALIRQYEMKDRKERKRLAEKKRLLEKAKMKGRKTKKATKNASKNGSQQQAYDRASADNSSGGGSGLPDDEYQGHEYDDDENLPIPPSAPASPTDLKPPLPPTGNYPKIAASVPGIKGTANSGASRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W6PZ00</accession>
    <name>W6PZ00_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Esterase, SGNH hydrolase-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S01g000993</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PZ00"/>
    <dbReference type="STRING" id="1365484.W6PZ00"/>
    <dbReference type="OMA" id="RYAMIFE"/>
    <dbReference type="OrthoDB" id="10071171at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01830">
        <property type="entry name" value="XynE_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053140">
        <property type="entry name" value="GDSL_Rv0518-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43784:SF3">
        <property type="entry name" value="GDSL FAMILY LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43784">
        <property type="entry name" value="GDSL-LIKE LIPASE/ACYLHYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G00820)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004881683" evidence="1">
        <location>
            <begin position="20"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="SGNH hydrolase-type esterase" evidence="2">
        <location>
            <begin position="222"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM27184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="430" mass="47232" checksum="A24B9BE7FD14544E" modified="2014-04-16" version="1">MFQLIYIFIISLRAHLVSSYPLLARGNHDGKNFHWVNIWTAMPQLVEPTNLPPVPFNGSTAVFNNTTIRQTLQVSLAAQEIRIRLSNVFGPNDLKISNATISLPARHQVGIRALQTDTLKTVFFDGSPDVDIPNGGLVVSDPIKFPVEAQSALMVNIYLAEGQQGFSITGHPGSRTTSYLALGDWTSAENLTDSSVQSTDHWYFISGVEACLPFESSGFVIIGDSITDGRGSTTNGNDRWPDLLLARMQKHKPTSNIAILNQAAGGNRIIQDGLGPNVISRLDRDVLAQSGVQYAMIFEGVNDIGVADSDAATQADIEKKLVAAYKQIVTRVHALGIPVFGATITPFGSSRSSEYVQLYSSAERERTRQRINKFIRESGIFYAVLDFDQVLRDPYAPSQLLEKYDSGDHLHPSVAGYQALADFFPLRVFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W6PZ29</accession>
    <name>W6PZ29_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="8">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PROQFM164_S01g001023</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PZ29"/>
    <dbReference type="OMA" id="NTHQIEN"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF2">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="18"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="214"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="244"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="280"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="311"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="1"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM27214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="386" mass="43638" checksum="33ADE5E9F05DB399" modified="2014-04-16" version="1">MCKSSEMSIHANERGPEVAINCSSLLAGIALSYWADFGFTRMSNQLSWRLPVSIQSIFALFSAAGIFFCPDSPRWYYAKGRTAEGDITLARLYNVYRVDNSAQPESASMELVRAEIMQNLQLEAEQENRLSWLSLVWDNTPLRVGRRIRISFIILSIQQMMGINIMVYYMPLIFSNVGLSSFLSSLISAVALTVQFTGSLVTIPTIERIGRRRIMLVAAAVQSCCMLVFVVLNGLPSKTEKTQWAAAAMMFPYMFMYGWGWVTCPWLYGPEIAPLKYRHIGAAVGLFGEWLFSFVTVIAGGIGLETSGWKIWIWPLIFNVLGFVFVYFMCPDPTGRTLEEIDALFDTDFRLPHTSDEKLSVHQIENTHQIENTHQIENTHQIENTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W6PZM4</accession>
    <name>W6PZM4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S01g002993</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PZM4"/>
    <dbReference type="OrthoDB" id="5404599at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM29181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="205" mass="23433" checksum="1A32E2B1E9F61299" modified="2014-04-16" version="1">MVCVVKILDDPVRDSITQVDTNTWLIGPFKLYRSKGYSDTSTWYDQEDDLSYTVTNAPIGSHWCMMLGMALPSEAAIAFVDRLVCEKKPGFEVPKLLYQTEYKDRYCLFLSRVQGRTLGDAWPSLDEKWRHHYANAVVDVCKFLASQECEEFRGVDGKNALEPFLVKSGAEEEYSPDNLRQFVYKWVWPAQNLCSTMPTSVLATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W6PZP0</accession>
    <name>W6PZP0_PENRF</name>
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        <submittedName>
            <fullName evidence="5">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PROQFM164_S01g003003</name>
    </gene>
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        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM164</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CDM29191.1"/>
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    </dbReference>
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        <property type="entry name" value="DUF7732"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42091">
        <property type="entry name" value="CONSERVED GLYCINE-RICH PROTEIN (AFU_ORTHOLOGUE AFUA_7G02440)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42091:SF1">
        <property type="entry name" value="CONSERVED GLYCINE-RICH PROTEIN (AFU_ORTHOLOGUE AFUA_7G02440)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24866">
        <property type="entry name" value="DUF7732"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004879502" evidence="3">
        <location>
            <begin position="19"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="274"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7732" evidence="4">
        <location>
            <begin position="136"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="65"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="87"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDM29191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="297" mass="29767" checksum="1B4F1B506198E702" modified="2014-04-16" version="1">MKFTWATTLLLLSTRALSLTIPQTESTDLIERDVDSLDSTQDSSDIITLEKRRGGGGGGRGGSSSGSSSGSSSGSSSGGSSGGRTGSSGSSGSSGSSGSSGSSGSSGSSRGGSTSNAGGTTSAGSGTRATYGGGNYYAGGARTPYTSGSRSAGGIAPYVLGGAALGFFPGLWLYSAYAYPYSQHYNYYNNNAHKNESLPVVCVCEQYSECGCDNNNNSTYYESLFNGTVPKNSSLVRVVDVNGTQTIYINGTLPNGTTAADGSSTSTSSASGPVAMVLHASGYWVTVAVVVAAVWGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q043</accession>
    <name>W6Q043_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PROQFM164_S02g000037</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
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            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM29888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q043"/>
    <dbReference type="STRING" id="1365484.W6Q043"/>
    <dbReference type="OMA" id="WCISNMA"/>
    <dbReference type="OrthoDB" id="2962993at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000034">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000068">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF18">
        <property type="entry name" value="NICOTINIC ACID TRANSPORTER TNA1, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G03820)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="39"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="79"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="135"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="225"/>
        </location>
    </feature>
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            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="334"/>
        </location>
    </feature>
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            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="436"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="43"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM29888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="492" mass="53593" checksum="905ED86EA1EBEDAA" modified="2014-04-16" version="1">MDSEKETLSQEIAPSPKVDAVGGANQPCPTELRRLLRKIDLRVIPILALLYFLSFLDRGNIGNAEIQGLSTDLNLVGNQYNWCLTIFFFPYSFFEPLCNLLLVRFKPSIWLPSIMVAWGVVTTLLGIVQNYSGLLAARFFLGLSEGGLFPGLAFYVSLWYPRANAQFRLALIFASASMAGAFSGLLAFAISKMDGVGGLEGWRWIFILEGLLTVVCAVLAFFVIWDEPSTATFLSDREKAIIIDLLADSRASSSEGQLEEKSAFDWKQFLAAVLDWQTWMHAISYWGAAVAVYALSLFLPTIIKGLGYSSAIAQLLTIPVYAAASIACIAVGYFSDRMGQRSLFTLVCYGAVFVGFLIAVAPSRFIPGLTYAGCFIAASGSYPAIPGLLALSSNNYAPATKRAVGMAIQIGLGSLGGAAASNFYKKTDAPRYRLGHSLVLAFVALGFLTVVLYYFLCRRINAKRDRGEATASQNPDGIFEMGDKAPTFRYNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q1W3</accession>
    <name>W6Q1W3_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S02g000687</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q1W3"/>
    <dbReference type="STRING" id="1365484.W6Q1W3"/>
    <dbReference type="OMA" id="MRLRKPH"/>
    <dbReference type="OrthoDB" id="3552571at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM30538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="92" mass="10951" checksum="D0D1CA9F8FFC6863" modified="2014-04-16" version="1">MNQTYSAGSCHVHDRMRLRKPHLKDNLPTQLCLLCNRAFCIDHEGKEDGVCEINHETYYRNHPDKQEYLFRTYGEWEKECEKMKADDMSGIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q2F9</accession>
    <name>W6Q2F9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Dbl homology (DH) domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S02g000878</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031991">
        <property type="term" value="P:regulation of actomyosin contractile ring contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:regulation of division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Bud3_C"/>
    </dbReference>
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        <property type="entry name" value="Bud3_N"/>
    </dbReference>
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        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051492">
        <property type="entry name" value="Dynamin-Rho_GEF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22834:SF21">
        <property type="entry name" value="GUANYL NUCLEOTIDE EXCHANGE FACTOR, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G11890)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22834">
        <property type="entry name" value="NUCLEAR FUSION PROTEIN FUS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12015">
        <property type="entry name" value="Bud3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25351">
        <property type="entry name" value="PH_BUD3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="3">
        <location>
            <begin position="246"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="782"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1069"/>
            <end position="1424"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1465"/>
            <end position="1573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="843"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1069"/>
            <end position="1088"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1119"/>
            <end position="1132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1153"/>
            <end position="1171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1178"/>
            <end position="1188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1252"/>
            <end position="1283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1375"/>
            <end position="1402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1403"/>
            <end position="1414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM30728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="1592" mass="175829" checksum="BC88D5A8F63D4070" modified="2014-04-16" version="1">MATIAPPSGICTLADLPLEHLSLYHVADPCLSSIFVFYGAVSTANATVSSSRIQAHIFTPAGFQSYPRITVSPAAPVYAAVNHLPREKQGDEVCRGLAVSMLRYFAELSEPVKHRLTGVARTGRPGGKVPKMFDEMHAADLANRMTKVDDSLEIIQDIRSAYQERKVPWVDIDVVLPTGTIQPFQRRESMGSDLEGGQNPQYGPYTPLIEALGDPMFLPTARLKRAPSQPTNVSKSRLFARSQKEALRLTMCELVDTEERYVAKLYSLVHEVADEFRQKAVGRGPSSNSPDEAALAALFPPCLNEILEVNLGFLDVIRHVLDETEKDAITDIGQDTELPSNRRGLPRDRSDPLGILAFAKALFEWLPQFSQPYGDYMRAHTGFTQTLNSFMKDKNSSFSKRVYETGEQRLRSLLMEPVQRLPRYSLLIDTMTSNLPLVHPAVRTLLKARDIVKDICALENNSPSSHTQSLQRLQELVNGWPAKTFPEGRLITAVDFNEITQPYRLDTQSSGRSSTGIMLLYKNCLVLLEKPAESRTTARGLLADIDNAAASTNDMSMSLPQSELQVVQVLDFHNVRCMQSTCGRILFAVPISAKSSKEETSSDLLALELAGTYEGRANRLIEEISKAKIEGRFPESEREGGKWTLRSPPTGSASNVGILACVCEDGESAALDQIQASPIRIVFDTSKATCGQMLRGSNLEVIISISPPNGDQYRLDIDSVVGSGSTDLITVDTFISTLSRRLQYLLSPLHSARNPALTNSLVHSNFEILRYIASSLITQVKSSRGFRPPSPTKLISNLLGGSRDNVPTLKGPGSATLTGEFPKMPPPRVNLSRSNTLPSAFPGKDKDKDKEKEKEKEETGNRISVVGTSASKGLDTQFGLLEQTFAAYVLSLQSRSGNILGRMLRVRDHVDRAPVNELYNILLEDPSRIQAAAEVPVDTLFVAFETFLANAWRTSMGPVLSSSSLKWIQSQFDTMIPRDFDEQFRKFVTDMSPQNRRALAAIIRLLAELLDASGNDGDRGALTMAFAEVLTEDGDPSHHVSLLDRLVEDFDNLFEEFIPGGTSVEGTLTCDQSKSHANTGSVGSNSSSFRKRFGFGMSRDTPKNEGESKVAAILRTLSKKQSPAGSELNTPKGSLMRSKSTDVDSRLGFLRPTSRDRPTSRDRPTSRDRPISRGSPASRDRPLSRDLPYRPYGFASEEQISRPGTGYDNPPSLSSFRGFSEDSVRRTRKKRRSSLSDIRPLTSSSDASSISPTQQLRPTTPSSRPQGEVVTPTNQSRPQSSYIPTPPMRGQSPMRSRPPAKSGSPTRLGSPIRRLSPPRPSTPSRKENIDPRAPQMERAFKSRGSVSESPADESRRRSQTSGIPQRIPGLRERPSSNASDTKRPQSSSGLQKPQKPRMQSPQKLRDRVQLEKRTQNSTQLGLKDELTELGNELRSLKLTPPRKPNAMNLEFDFDRTDINPHAATAASLEARMRNLEARFETVTGEYKCRTSALERDLESSLVLSEKRVKKLDELYREASAENEALYDRFNTELSKIAKDVRLGHAEDALKSQLASALDEIGRVKKENFRLKREVGGLRAQSAAAALLKASEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q2U8</accession>
    <name>W6Q2U8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S02g001038</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q2U8"/>
    <dbReference type="STRING" id="1365484.W6Q2U8"/>
    <dbReference type="OMA" id="RYADVQP"/>
    <dbReference type="OrthoDB" id="5578001at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="275"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="307"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM30888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="376" mass="41145" checksum="D2D325312748CDA4" modified="2014-04-16" version="1">MVELINPPETRELLPPLLACLPLAFVSPRAPPALLPLLSPILRQRVGVLSSLSTSSTESWLQLLCWEAGKAERLQRVIDGATFEPHPVSGEIELPDELPVTYKRIDDETLKAQVPLAEYSLTVVYLWCPTDEEGGGRGWRVAELLPREGAAEDDDKWASSIWEANVQAKDQLLTDILKAAEEEKSPENSMENDDDDDDDYWAQYDSTPGAKTPAPPAASSKPGPSHLSEQSYFSQYGDVQPAMDNHDPTEEQPEVGPSSLNGDMLANLLRRQVNGVNSDDEPRKNGYAPDHIPSDKAAQDLNHPRPASASSGSSDAIAKLEHEAESRSTCEVGVKQHIGTSIKSLFRLAKVTGMSRGEFQALVSMELELLDITDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q315</accession>
    <name>W6Q315_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized conserved protein UCP037991, UAS/UBX</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S02g001118</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q315"/>
    <dbReference type="STRING" id="1365484.W6Q315"/>
    <dbReference type="OMA" id="PAIFDCQ"/>
    <dbReference type="OrthoDB" id="270602at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02958">
        <property type="entry name" value="UAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14273">
        <property type="entry name" value="UBA_TAP-C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01767">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006577">
        <property type="entry name" value="UAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001012">
        <property type="entry name" value="UBX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050730">
        <property type="entry name" value="UBX_domain-protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23322">
        <property type="entry name" value="FAS-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23322:SF6">
        <property type="entry name" value="UBX DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13899">
        <property type="entry name" value="Thioredoxin_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14555">
        <property type="entry name" value="UBA_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00789">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00594">
        <property type="entry name" value="UAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50033">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBX" evidence="2">
        <location>
            <begin position="427"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="367"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="378"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="395"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM30968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="508" mass="56293" checksum="69680E933933C87E" modified="2014-04-16" version="1">MENDVVAQFTEITGSTPELAIQYLQITEFQIEQAMQLYFESGGAPLTGEPAQPSHRSGIPDDADVVNIDSDTDDETPQQSGLPTLDDDEAMARRLQEQMYGGPGGLDNDDEVRAPLARTTETLVGPGADYDSGEDMHANILSQLRARGRSGRAGIFNQQESSSIWTGDDESRREQLAAVTGGASEVSSKSNMLAEMYRPPFEIMSRLPWDVAREEGKDTEKWLLVNIQDASVFDCQVLNRDLWKDSGVQDTVKEHFIFLQYSKDDPRASSYLQYYFQGSDVSDNYPHIAIVDPRTGEQMKVWSGPPLVKPADFLMQLHEFLDRYSLNHNVRNPVAKRKSDKKDKSIDAMTEEEMMEMAMRNSLGGAAEAGQTLEDPDDLTRSTDTVKGKGRATSDEDVTMDEPDPAAEASPFASIPSDQPHTEPAADPATTTRIQFRHPSGRVIRRFSLSDPVQRIYEWLKADPPLADKAGVEFDLNSMGHNLIDQLTTSIADAGLKNGTVMIGYLEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q539</accession>
    <name>W6Q539_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S02g001894</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q539"/>
    <dbReference type="OMA" id="PIPCSNT"/>
    <dbReference type="OrthoDB" id="5421041at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="475"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="41"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM31743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="504" mass="56691" checksum="FB3E65B40F1FF3E2" modified="2014-04-16" version="1">MSSIDSSPLVNSGSLRGFVKYMGILASSSEAQFASAVLGEITQQRERNHFQEEELKKLRKEILEINETKRTTIADMFIANENEKAKQRDSATQIESLRATIDAKEKNIAAFSKDLGASKQKIAKLELNLSQELTKGTKSADEINVLRESLKEKDRTIDQMRTAGSKLKSMLSAEEKKTKDLEGANTSMDTELQAVKAHIQRLEEFPIQPSAILEDFVVTKFTSLWTSAKSGLFPLLEQDVPEDTLKEKSIWEKLRKADRILLPPSFPLIPSNSLAAKAVRSALILAVLFREIDRRIFKPSYFLSGRNSLHEALSHLAENNGEKEAFCRRILLSIDPHAEYVALKAEIQAVVQTMSSFVEGLFPEAQHELFRTKTKSIVQDAAEFWLPIQRSQQKFEIDFEPSDLDDNEWDRFPLAGENTKPVAQDIHGFYLLNVFPCISLVEDGDHDPLTKVIQLRDSQELYLAAQNEATQVATSAITRRPRPRRQSTAGSNRRPFLGGNSTKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q5C3</accession>
    <name>W6Q5C3_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pantothenate kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PROQFM164_S02g001994</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q5C3"/>
    <dbReference type="STRING" id="1365484.W6Q5C3"/>
    <dbReference type="OMA" id="WSKGAKQ"/>
    <dbReference type="OrthoDB" id="498611at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004594">
        <property type="term" value="F:pantothenate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd24123">
        <property type="entry name" value="ASKHA_NBD_PanK-II_Pank4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000115">
        <property type="entry name" value="Pantothenate kinase PanK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.510:FF:000005">
        <property type="entry name" value="Probable pantothenate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.510">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004567">
        <property type="entry name" value="Type_II_PanK"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00555">
        <property type="entry name" value="panK_eukar"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12280:SF20">
        <property type="entry name" value="4'-PHOSPHOPANTETHEINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12280">
        <property type="entry name" value="PANTOTHENATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03630">
        <property type="entry name" value="Fumble"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="310"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDM31843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="453" mass="50570" checksum="BC763852850EACB8" modified="2014-04-16" version="1">MASERMEVDTNARRKRPNRLEAAITNPGAVKINVTGAFIVDDEPRSKSPVEAEGVHYENKDIRLPHHTGVVSHVAVDIGGTLAKLVYFTRELETADNGGRLNFLNFETHRIDLCINFIRHLKEEHEKRNGSTREGLCVVATGGGAYKYYDRLKEELNVNILREEEMECLIIGLDFFITEIPNEVFTYSDTDAEPLQYAEARPDVYPYLLVNIGSGVSMIKVSGPRQFERVGGTHLGGGTFWGIMSLLTGSRTFDDMLAMADRGDNSAVDMLVGDIYGMDYTKIGLKSTAIASTFGKVLRLKNDAEQVAEDGEGLIRDDPSEASESNHGIKPKPEDMSRSLLYAISNNIGQIAYLQSEKHSVKHIYFGGSFIRGHRQTMNTLSYAIRFWSKGEKHAYFLRHEGYLGAVGAFIQRQPQNWGRRNSVDDVVAPQAVRNIVQNSHVLQQHGRSSSDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q5N0</accession>
    <name>W6Q5N0_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S02g001785</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q5N0"/>
    <dbReference type="STRING" id="1365484.W6Q5N0"/>
    <dbReference type="OMA" id="WIHLAPR"/>
    <dbReference type="OrthoDB" id="4453902at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM31635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="291" mass="33733" checksum="12FAF87302B42E6B" modified="2014-04-16" version="1">MDKQTQTRRCDEVKRLYKLLKSCESWFLSPGDLQGLGIYSQQVGMTGDGSVQFGPCFFRPYPEKVLQKYPLDTVSMAADHPPQTLQRLNNPRDFQTLLREVQNDPKVEHPLEFAKSRWDTLTLLYGPDAWEDHARQTRWHIQSQQMLPRRGLSRDSTLSDLRSIYERRRNYWRILSLREVFQPSFNPHAIMELLSDVPANHAENCLTLQEVSAVVTVMVARTSDRPFRDHPIHPLLVLSYTGQNHGRIIQASLHGESLLLQYSQLWSFADDETAPVELFIRYDMSQPVPIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q653</accession>
    <name>W6Q653_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PROQFM164_S02g002339</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q653"/>
    <dbReference type="STRING" id="1365484.W6Q653"/>
    <dbReference type="OMA" id="IVENDHI"/>
    <dbReference type="OrthoDB" id="2113314at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056825">
        <property type="entry name" value="Agd3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056826">
        <property type="entry name" value="Agd3_CE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056827">
        <property type="entry name" value="CBM87_Agd3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050788">
        <property type="entry name" value="Yeast_SRP1/TIP1_CWP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31002:SF34">
        <property type="entry name" value="CELL WALL PROTEIN CWP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31002">
        <property type="entry name" value="SERIPAUPERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25117">
        <property type="entry name" value="Agd3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25115">
        <property type="entry name" value="Agd3_CE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25116">
        <property type="entry name" value="CBM87_Agd3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004879384" evidence="2">
        <location>
            <begin position="29"/>
            <end position="1068"/>
        </location>
    </feature>
    <feature type="domain" description="Agd3 CBM87" evidence="4">
        <location>
            <begin position="410"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="domain" description="Agd3 deacetylase" evidence="3">
        <location>
            <begin position="634"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="domain" description="Agd3 C-terminal" evidence="5">
        <location>
            <begin position="1000"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF25117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDM32188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="1068" mass="109530" checksum="B09A22196E578161" modified="2014-04-16" version="1">MVAVPVWALKVACYYAFITCDTAPGVWPENTPTVIAYHPPVSTPSSTSSSTAEVSSTAVATSTLSFTSSASVPALSSIVTGSLPTVAPTTTAASTFVTFTTSSSIVDSASASVTVTVPSGSSSVLTQSGSSSVSSASSSSAVSSASTVVASSSASSSPVSSATSSASSSSIVSPSESSSVSSPASSTVPSSPASSSLVSSVTSSSVVSSSASSSVSSTSTAVPSSSASSSAASSAASSPAVSSPGSSSISSASTAIPSSSASSSPASSATSSSVITPSGSSSVSSVVVPSSSASSSPASSATSSSVISPSGSSSVSSIAVPSTSASSASSVASSSAVSSPGSSSISSASTAVSSSLASSSAVSSATSSSVVSSASVSTSASLTTPIMSSTLISISASATASATPLSHAAVAAEILIIARDAASAGVASSGLNGYGIPFSTLIVPSAGVELPELNGTAGGNFGGIVVASEVSYDYGTLGFQSALTTDQWNQLYAYQLEYGVRMVQYDVYPGPNYGASAIGGCCDGVEQLISLTDTSEFPTSGLKTGAGISTTGLWHYPATISNTTSTKQFAAFAPTTGFETESVAGVINDFDGRQQMAFFIGFDTTWSSTSSYLQHAWITWITRGLHAGYRRVNLNTQIDDMFLETDIYSPAGTTFRIRAEDLTNIASWIDTINAKLPAGSSYFVEVGHNGNGNIENASDTSDAGWDTCGAAIEYDSPLDTPLEWIKPLGTGTDLWPATPTAYDWEATCTVMDELLAWWTTESNLNKFGHISHTFTHEEQDNATYSDIYKEISFNQAWLKQVGIDKATKFTSNGIIPPAITGLHNGDALQAWWDNGIVNCVGDNTRSALLNQENDMWPLFTTVANNGFDGMQVNPRWASRIYYNCDTPDCTVAEWIATSAGVGGFQDLLDIEKAETMRHFFGLFHDPYMFHQANLRNADVDPITINGVAEKYSIMQAWVETQVQEFIRLAEWPVVTLTHQEMSAAFLARFNRDKCGYSLSYATSNQKITAVTVSATGNTCTDPIPVTFPVAPTSTLGFATEQLGADPLTVWVELTGSPVTFTLSTPISF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q670</accession>
    <name>W6Q670_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Calcineurin-like phosphoesterase superfamily domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S02g001656</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q670"/>
    <dbReference type="OMA" id="SRPRMHC"/>
    <dbReference type="OrthoDB" id="630188at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07379">
        <property type="entry name" value="MPP_239FB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051693">
        <property type="entry name" value="UPF0046_metallophosphoest"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12905:SF0">
        <property type="entry name" value="CALCINEURIN-LIKE PHOSPHOESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12905">
        <property type="entry name" value="METALLOPHOSPHOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="1">
        <location>
            <begin position="12"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM31506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="309" mass="34388" checksum="714852A9BBB3E1AE" modified="2014-04-16" version="1">MAETASANVKTRFLVFSDTHGLDTPPNFVSRHYADVAIHCGDLATESKIDEYKASIRFLQAVNAPLKLVIAGNHDFTLDTPMFQKKVAEAQPLDPQLVQKVYGNYEEARGLFEKETGITFLDEGIHSFRLQNGALLNVYASPYTPSLGDWGFQYHPERGHDFRIENVDVVMTHGPPKGIMDYTHSGQRAGCPHLFKAVARAQPRPLMHCFGHIHEGWGAKIVRWRQKVSLEPSHLTDIDNEKSVLVSRLSTIKGKGNPTECSTTSNCSEDHNPLQRGSETLFINAAIEGYEDPSIQPPWLVELELPAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q6T8</accession>
    <name>W6Q6T8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RNA polymerase II accessory factor, Cdc73</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PROQFM164_S02g001857</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CDC73 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q6T8"/>
    <dbReference type="STRING" id="1365484.W6Q6T8"/>
    <dbReference type="OMA" id="FRPDYWN"/>
    <dbReference type="OrthoDB" id="2186602at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016593">
        <property type="term" value="C:Cdc73/Paf1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11990:FF:000003">
        <property type="entry name" value="Pol II transcription elongation factor subunit Cdc73"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11990">
        <property type="entry name" value="RNA polymerase II accessory factor, Cdc73 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007852">
        <property type="entry name" value="Cdc73/Parafibromin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031336">
        <property type="entry name" value="CDC73_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038103">
        <property type="entry name" value="CDC73_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12466">
        <property type="entry name" value="CDC73 DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12466:SF8">
        <property type="entry name" value="PARAFIBROMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05179">
        <property type="entry name" value="CDC73_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="Cell division control protein 73 C-terminal" evidence="6">
        <location>
            <begin position="283"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="240"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="336"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="270"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="340"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM31706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="472" mass="50777" checksum="DF52BD8B63F704C0" modified="2014-04-16" version="1">MATEAALQDPLLALRRAIASGNLPTPTTSSELSDQPATDDLAKATHLYFAQPAPQTIALSTLTRFISASTKAPVDLRSILFAWQNKDVAIPEYIAKAQEFNEALKKQTPEGGKEESVQILIFLERLDLFTWLEGASDDSEHIKPLEGAAAAAEAAAAAAGVAQADNAAGIAAGAIGGITSVPSGTAGAAQAGTQPGRPQKQIDPRLQEIYNGERKTGDRNTVLRGIKPTDFSHVRKSAEVFLDRNRNRPGQPGVKPGSKGSIPAPSAGLSMPSSRKSSSSHSRPDPIILISPSASSLIRMSNVKSFLEEGIFVPPDHPTLTGTTDANLVKLERPLRLNGDASNPASASSRAGKPTRPTKFIVVDGTTNFKPEYWNRLVAVFTTGQTWQFKSYKWSSPPELFKHATGVYIGWRGEDIPSQVKGWGRGVDTFAVERWDEKNGVHGGGRWRDREVVEGIWTAIEEGMRLRGWGTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q7T3</accession>
    <name>W6Q7T3_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Cytochrome P450 monooxygenase poxM</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Oxaleimides biosynthesis cluster protein M</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PROQFM164_S02g000443</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">FM164</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 15">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q7T3"/>
    <dbReference type="STRING" id="1365484.W6Q7T3"/>
    <dbReference type="OMA" id="AMMELRM"/>
    <dbReference type="OrthoDB" id="6692864at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902181">
        <property type="term" value="P:verruculogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11061">
        <property type="entry name" value="CYP67-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000063">
        <property type="entry name" value="Cytochrome P450 monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF78">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 15" id="KW-0349">Heme</keyword>
    <keyword evidence="10 15" id="KW-0408">Iron</keyword>
    <keyword evidence="12 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="15">
        <location>
            <position position="511"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00068045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00081244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CDM30294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="569" mass="63880" checksum="A191A594E2E1CF38" modified="2014-04-16" version="1">MAVATSLAVLLSPAPLRIAPTFLVLGAAFHQFIRPYEIDNNIFSLAALYLGNILALCAAWTYAYSLSVPRAIGCTLLAACYFNVGLTVSILVYRAFFHRLRKFPGPWTAKLSRLSAVNRAIKRTQHHRDLQEMHEKYGDFVRTGPREISINRPSAVVAVNGSHSPCTKAPWYSHVSDDSSKISLNSTRDPNIHRRRRKAWDRGFSMKAISLYEPIVQNKVNVLATQIRSRLNQPLDAAQWTMFLAFDVMGLVGFSQDFHQLENGTEQPAVKELHQQLLYIGILKPAPWILTILGGIQGLVGDYGRFMTYCADRIADTKKRWNSRSDKDSEKLPKDVISWLLKAIEEKDPSAPPGDQALNEDGRLMIIAGSDTTGTTLAHALYFLAKTPTAYKKLQKELSDVFGKAAEPSQFTNSKLQNLPYLEAVINETLRLKPAVPSGQPRLTPPEGLQIDEVWIPGNTIVVLPQYVLHRDERYFPSSLEFIPERWLDEKNNLVKHEEAFFPFQLGRYGCVGKQFALMELRAVIARVAYNFDLAFAPGETGVSFDDDSKDTFTFSIGSLPLVFTERSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q8G4</accession>
    <name>W6Q8G4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S02g002826</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q8G4"/>
    <dbReference type="OrthoDB" id="10276356at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM32675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="64" mass="7464" checksum="36CE94AB5AA0625F" modified="2014-04-16" version="1">MQLATQLLQSRYEDTIAWEEIESDTASGEYFLTETARREVPKRAVADEEELYEITGTLEMNEYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q8K1</accession>
    <name>W6Q8K1_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Basic-leucine zipper domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PROQFM164_S02g000724</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q8K1"/>
    <dbReference type="STRING" id="1365484.W6Q8K1"/>
    <dbReference type="OMA" id="HGAFMSQ"/>
    <dbReference type="OrthoDB" id="295274at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14687">
        <property type="entry name" value="bZIP_ATF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000053">
        <property type="entry name" value="BZIP transcription factor AtfA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051027">
        <property type="entry name" value="bZIP_transcription_factors"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021755">
        <property type="entry name" value="TF_Aft1_HRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021756">
        <property type="entry name" value="TF_Aft1_HRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020956">
        <property type="entry name" value="TF_Aft1_OSM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19304">
        <property type="entry name" value="CYCLIC-AMP RESPONSE ELEMENT BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11786">
        <property type="entry name" value="Aft1_HRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11787">
        <property type="entry name" value="Aft1_HRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11785">
        <property type="entry name" value="Aft1_OSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="8">
        <location>
            <begin position="344"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="241"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="369"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="92"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="158"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="241"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="261"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="319"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM30574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="454" mass="48688" checksum="ED08939DBC2DC804" modified="2014-04-16" version="1">MKPPARSQNRSDSQAASKDQKSNLETQTSLAPPPRPGAPTASDTPDYFNSMHNPFSLEPNPFEQSFGGNPADTPGKSLLPSVAALTSPALPGTSSSSGYNWNNSLRAGPLSPAMLPGPTGPNDYFDSIGRGFPTPNESSLRTGLTPGGGGSMFPAPSPNSQALLQQLQNGGATPSTIDFHRTALTAKKNNSNAPTSNPNEQDQAAVNMEVKPARPADFTQHDAADAANGLFMLAKGGQANNAPMNHAQMSNDARSAAARRVSQNTNGTSVGDASDRESAKPAKGKGKKNTKGSTNNRRKAEEAPKGSNKRAKPNMDMPSDMDDEDEDDDDMKQFPMDTKKMTDEEKRRNFLERNRVAALKCRQRKKQWLANLQNKVELFTSENDALTATVTQLREEIVNLKTLLLAHKDCPVSQAQGLGPLMMNGMSAGYDHHGYNMPPNMGMQGGIPTQGMRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q8Q6</accession>
    <name>W6Q8Q6_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Btz domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PROQFM164_S02g002517</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CASC3 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1365484.W6Q8Q6"/>
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                <person name="Renault P."/>
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                <person name="Gouzy J."/>
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        </source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
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</entry>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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    </dbReference>
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        <source>
            <dbReference type="ARBA" id="ARBA00020998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM26352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="181" mass="19971" checksum="334EB745E8F697C7" modified="2014-04-16" version="1">MPPNIPRGTWSLTRSILRPLLRSQIPYTLRLASCFAGINPGTTPQQSARLLNIFKRSHRQSNIHSKHKMSTSTPDRYKLVFFVPTANVEHCKEAIFATGAGSFPGGKYTKCCFQTVGTGQFLPNEGADPAVGAVGALERCEEVKVEIMCLGRGVMLNAVDALILVHPYEEVAYEVYKMENV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q9E8</accession>
    <name>W6Q9E8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PROQFM164_S01g000201</name>
    </gene>
    <organism evidence="6 7">
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        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
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                <person name="Debuchy R."/>
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                <person name="Lacoste S."/>
                <person name="Sallet E."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792015">
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="MFS_trans_sf"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF60">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDM26392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="102" mass="11490" checksum="F65B87F66DB9DBA2" modified="2014-04-16" version="1">MAIFIAYNYGVLFFVLTSFASLWTKRYHQSVLISGVHYVAIVLGYTVGSPGGARVTDWLWKYLTHKRGQTAPEYRIPLIFPGIVFLIAGLSWYGWTAEAMAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q9J9</accession>
    <name>W6Q9J9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Frag1/DRAM/Sfk1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PROQFM164_S01g000256</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q9J9"/>
    <dbReference type="STRING" id="1365484.W6Q9J9"/>
    <dbReference type="OMA" id="TMIGEPR"/>
    <dbReference type="OrthoDB" id="10032492at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019402">
        <property type="entry name" value="CWH43_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050911">
        <property type="entry name" value="DRAM/TMEM150_Autophagy_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21324:SF2">
        <property type="entry name" value="EG:22E5.9 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21324">
        <property type="entry name" value="FASTING-INDUCIBLE INTEGRAL MEMBRANE PROTEIN TM6P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10277">
        <property type="entry name" value="Frag1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="154"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="CWH43-like N-terminal" evidence="6">
        <location>
            <begin position="5"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF10277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM26447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="235" mass="26281" checksum="D43CCE162B9DE48C" modified="2014-04-16" version="1">MFLPSWVFPAVAASTWLAMLLTMLGHWTMIGEPRYGLMKPGQNIPFISDIGAQELKPLFMIGSITTVLLLNLSFYQHVQNKSYISKACTHGSFLFTVVGSIGLIMLSVLDNIAHHFMHDVCVTIFIVGFLVSAALMCLDYIYLGIAHALRQPMLMTSFLIKSSFIVVELALIIVFRVTEHTHYNQNNMAATLEWVIAFVFTGYILSLIVDLMPSAHKNLHNPKGYQPVQMSMALP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q9V0</accession>
    <name>W6Q9V0_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Zn(2)-C6 fungal-type DNA-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PROQFM164_S01g000371</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q9V0"/>
    <dbReference type="STRING" id="1365484.W6Q9V0"/>
    <dbReference type="OMA" id="ISRIMMA"/>
    <dbReference type="OrthoDB" id="435881at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF50">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="48"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="108"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="211"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="694"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="117"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="154"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM26562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="813" mass="91158" checksum="02AAC97AC3EB750B" modified="2014-04-16" version="1">MSFPPASPEELNPFPVNYNSSNTPLPPNLAATFPRHAATEPPSSTSRSCVTCRRRKVRCNKRSPCSNCTKAGIDCTFPPPGRAPRKSKRPPDAELLSRLRRLEGVIDHLRGNGDTEGGSTSTQAPPSTTGSSTVRSEPTAPTSVSTEPQNQVDGGRHCPFEASDPKKLAPNKFENEFGRLVIDEGRSRYVSNRLWTSLGDEIEELQDILDHSSSGEDDTPSPESSQSASHDGFLFGFYSLSKSLRELHPPMPKVSLLWETYQENVAPLVTIVHRPTARDLFSQAARNPDALDKNSEALVFSMYLCSIVSMKPDDCWFQFGEDRTIAVKRYRFATEQALAKAGFLNTQSLVLLQAAVLFLVCVRREDDSKFVWSMTSIVLRLAQSLGLHRDGSNFALKPYETEMRRRLWWHISLLDVRSSEDHGTDPLIHESMYDTLLPLNLNDDDLSPDMEEPPKEREGFTDVTFCLIRCEITSALRRANYVCPGAQFRSPNSLPPIDRAGRMIQIISDRCEQRYIKHCDMNIPLQWCTATVGRLILAKLWLIVHHPMTRKERGNVSQATRESLFLTAIEVLEFGHLLETDLKTAKWGWLFRTNMQWHGIAFVLSEVCVRPICPITDRAWSAVSSIYTEWAMQATHKKGMLWRPLAALMKRAAATRSKHKEELISSFGPFPTATEPIQSINHNHTLPRIHMPIGMPNSPSIDRPGSTASDTDYDPSNGPLGALRNMFPGINILATSNDIFDAPPAQNNISAPSLPTSLPYNTTMINPFLNEAPLPDTTQLNWEEWDQVMRDFQMDVENDDSLPTNGNVAEWFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W6QA28</accession>
    <name>W6QA28_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S02g003392</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM33240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QA28"/>
    <dbReference type="STRING" id="1365484.W6QA28"/>
    <dbReference type="OrthoDB" id="1577640at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM33240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="87" mass="9725" checksum="872755B6A787278E" modified="2014-04-16" version="1">MDEQRATHVLRNSLIDKEFLYDTENSPELLEQLTCVPLASVQAASFINENSMTIASYVKLLVGQEQSAIDLLSQDFEVDAKAFETLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2024-10-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>W6QAU6</accession>
    <name>W6QAU6_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S03</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S03g000314</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QAU6"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM33590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="30" mass="3398" checksum="C281C604F49C6370" modified="2014-04-16" version="1">MSRLSGSRSGWTVMIDLSTRPLLVQHMPLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W6QB12</accession>
    <name>W6QB12_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Presequence protease, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Pitrilysin metalloproteinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">cym1</name>
        <name evidence="16" type="ORF">PROQFM164_S01g000701</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Degrades mitochondrial transit peptides after their cleavage in the intermembrane space or in the matrix, and presequence peptides; clearance of these peptides is required to keep the presequence processing machinery running. Preferentially cleaves the N-terminal side of paired basic amino acid residues. Also degrades other unstructured peptides. May function as an ATP-dependent peptidase as opposed to a metalloendopeptidase.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer and homodimer; homodimerization is induced by binding of the substrate.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion intermembrane space</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase M16 family. PreP subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QB12"/>
    <dbReference type="STRING" id="1365484.W6QB12"/>
    <dbReference type="OMA" id="NYLYYIR"/>
    <dbReference type="OrthoDB" id="10250783at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000020">
        <property type="entry name" value="Mitochondrial presequence protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000009">
        <property type="entry name" value="Presequence protease, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000011">
        <property type="entry name" value="Presequence protease, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013578">
        <property type="entry name" value="Peptidase_M16C_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055130">
        <property type="entry name" value="PreP_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43016">
        <property type="entry name" value="PRESEQUENCE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43016:SF13">
        <property type="entry name" value="PRESEQUENCE PROTEASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08367">
        <property type="entry name" value="M16C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22516">
        <property type="entry name" value="PreP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01264">
        <property type="entry name" value="M16C_associated"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 16" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M16C associated" evidence="15">
        <location>
            <begin position="519"/>
            <end position="777"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00020167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CDM26892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="1042" mass="116461" checksum="3E43A33581DFD571" modified="2014-04-16" version="1">MLRSSMRLGTARVPKSNPLISRSLKSTQTVLPRNTRRAASTVTNLDNFPKVGEKLHGFTLQEKKHVPELHLTAVWLKHDRTDADYMHVARDDKNNVFGIGFKTNPPDATGVPHILEHTTLCGSEKFPIRDPFFKMLPRSLSNFMNAFTASDHTTYPFATTNQQDFQNLLSVYLDATLHPLLKESDFRQEGWRLGPEDPRAGESIPGQAEKQLSLEDIVFKGVVYNEMKGQISDANYLYYIRFKESIFPSLNNSGGDPEYITDLTHKQLTEFSKRNYHPSNSKILTYGDMPLADHLQQIGTVLDGFQKGHADTDIKLPLDLTKGPLNVTVPGPIDTFASEDKQHKTSTSWYMGDTTDIVETFSVGIVSSLLLDGYGSPMYRALVESGLGSSFTPNTGLDPSGRIPIFSVGLNGVTEAEAPNIKNVIQNVFRESVSAGFSEEKIRGFLHQLELSLRHKTANFGIGVMEKTISSWLNGSNPMKELAWNDVIDEFKRRYAKPGYLESLVEKYLINDQCMTFTMVGTPTFNKELDEKEVVRKDKKLAQLIEEHGSVEKAVTKLGEEELELLKIQEDAHNADLSCLPSLRVKDISREKERKPVRESKVEGADVVWREAPTNGLTYFQALNDFVDLPDELRLLMPLFNDCVMRLGTANRSMEQWEDLIKLKTGGISTSSFLVSSPTHLDHFKEGLQFSGFAIDKNIPEMLEILSVLVTETDFTSPAAPAMIQELLRMTTNGALDAIAGTGHRFAVNAAAASLSRSFWIQEQQSGLEQLQATANLLRDAESSPERLQELIEKLRLIQSFAISSSNLRVRVVCEKESAGNNELILQKWISGLPRTQSPSANLTTSSFKSADKAFYEMPYKVYYSGQARQTVPFVDPSSAPLSILSQLLTHNYLHPEIREKGGAYGAGASNGPIKGIFTFMSYRDPNPLNSLKVFKNSGIFARDRAWSEREIEEAKLGIFQGLDAPMSVDDEGARYFMSGVTHEMDQRWREQVLDVTAKDVNAVAEKFLVNGSRQATCVLGEKKDWADSEWELRKLSMDAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W6QBB5</accession>
    <name>W6QBB5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Genomic scaffold, ProqFM164S03</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S03g000464</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QBB5"/>
    <dbReference type="STRING" id="1365484.W6QBB5"/>
    <dbReference type="OMA" id="IFLYTSW"/>
    <dbReference type="OrthoDB" id="3784821at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM33740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="88" mass="10364" checksum="E8DA9CB5A8ED8170" modified="2014-04-16" version="1">MSSLKDQQRYRSMDPKTRPPRPIQQPAASRLPKGVDDIRKTKEYKTAARRWTTTIVGLPIVIYTSWILYERLYLGKSPKSREDQKQKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W6QBF8</accession>
    <name>W6QBF8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alcohol dehydrogenase, iron-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S03g000080</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QBF8"/>
    <dbReference type="STRING" id="1365484.W6QBF8"/>
    <dbReference type="OMA" id="GTRIGMQ"/>
    <dbReference type="OrthoDB" id="339764at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08192">
        <property type="entry name" value="MAR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1090.10">
        <property type="entry name" value="Dehydroquinate synthase-like - alpha domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001670">
        <property type="entry name" value="ADH_Fe/GldA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056798">
        <property type="entry name" value="ADH_Fe_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039697">
        <property type="entry name" value="Alcohol_dehydrogenase_Fe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496:SF107">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G06800)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25137">
        <property type="entry name" value="ADH_Fe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00465">
        <property type="entry name" value="Fe-ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56796">
        <property type="entry name" value="Dehydroquinate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA" evidence="2">
        <location>
            <begin position="28"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="Fe-containing alcohol dehydrogenase-like C-terminal" evidence="3">
        <location>
            <begin position="204"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM33356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="408" mass="44005" checksum="63A7CEB24CF582B3" modified="2014-04-16" version="1">MPQETVRPAFEGRERPLLSYGLAFPAATARHLDDIFQASRVYVICSGSLARNTDVMNQLEAALGPDKLVGHWIGMRSHTLWSEVLQIAEEVRTVHADLLLTVGAGSLTDGAKIIALALANQVSTLEELETLAEGPKKRLGIKAPTLPIISVPTSLSAGEYSNFAGGTEDRSKRKYSFQNPIRGPELVILDPELAKTTPNSIWLSTGVRAIDHCIENLCSTSGTTPESDKLARDALGLLVPGLLRCKNDRSDREAHLQCQLGSVDAMAACTSGSIELGASHGIGHQLGPLGVGHGETSCILLPAVCKFNAKYNANREKQASVCQFLIQDPVVSEVLRARSVNVEASDLGDILDAIIRELGMPRSLSDVKVGRDQLDGLAENSLHDRWCKTNPVPLKEKSQVLEILEMVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W6QCG5</accession>
    <name>W6QCG5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cystinosin/ERS1p repeat</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PROQFM164_S03g000899</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QCG5"/>
    <dbReference type="OMA" id="YYEKKWS"/>
    <dbReference type="OrthoDB" id="407617at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051415">
        <property type="entry name" value="LAAT-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201:SF37">
        <property type="entry name" value="PQ-LOOP REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201">
        <property type="entry name" value="SEVEN TRANSMEMBRANE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00679">
        <property type="entry name" value="CTNS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="42"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="188"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="228"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="238"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM34175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="261" mass="29007" checksum="D90E649B2478B3A9" modified="2014-04-16" version="1">MDNRVAENVLGTLGAVCWSVQLIPQIVINYRRHDTEGLQGSMMLLWATAGVPLGVYNIVEEFNIALRIQPQILMTLSLITWAQCLYYGKKYRIMKCCVAVTSLLLLFGGIEAGLIFALQAAKRRGLEWPLILMAVLSACLLAAGVLRHYWDIYVHRTVRGISFIFVGIDAAGDLFSLLSVLFGSTISALGIIIYGTELTLWVGIFICGGIFNLRPWIKERSEQRNGNLQEPVSLHPMPSSTSVFRTASASQVTERRPWQSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W6QCP3</accession>
    <name>W6QCP3_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glycoside hydrolase, family 2, TIM barrel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PROQFM164_S03g001197</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QCP3"/>
    <dbReference type="STRING" id="1365484.W6QCP3"/>
    <dbReference type="OMA" id="LWAPEHP"/>
    <dbReference type="OrthoDB" id="408320at2759"/>
    <dbReference type="UniPathway" id="UPA00280"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051913">
        <property type="entry name" value="GH2_Domain-Containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006103">
        <property type="entry name" value="Glyco_hydro_2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006104">
        <property type="entry name" value="Glyco_hydro_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006102">
        <property type="entry name" value="Ig-like_GH2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42732">
        <property type="entry name" value="BETA-GALACTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42732:SF4">
        <property type="entry name" value="BETA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00703">
        <property type="entry name" value="Glyco_hydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02836">
        <property type="entry name" value="Glyco_hydro_2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02837">
        <property type="entry name" value="Glyco_hydro_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="beta-Galactosidase/glucuronidase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl hydrolases family 2 sugar binding" evidence="6">
        <location>
            <begin position="19"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 2 immunoglobulin-like beta-sandwich" evidence="4">
        <location>
            <begin position="223"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 2 catalytic" evidence="5">
        <location>
            <begin position="360"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM34473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="665" mass="74321" checksum="47E810A72AF0D0A3" modified="2014-04-16" version="1">MTASYPRPDFQRTSLNWNTLNGPWTSTFDDKDEGLISQWQKTSLEGIPSHQITVPYAFQTPASGVNLIEAHEVMWYERRIIDIRTANEKQKGNRLLLRFGAVDYECSVWVDGVLVGGHRGGHVPFDIDISDVIADGATEARLTLRARDSPYDMTQLRGKQFWGPVPESIFYTPTGGIWQSVWLESVPAMRLLCGSGGTVIRSDDIEGGKLHAKVQVAGRRVGSAAKVEVEVSLGGLGIAKVHGELPRDKTFVALDLSMTVTEAVVAQLKTKNQKLFGVDGVWSRGVALWAPEHPVLYDITLRLFDGAGGLVDEVQTTTGMRSLNWQNGDGTFQLNGKPYFQMLFLDQGYWPETGLTPPSSEALKTDIELAQKLGFNGCRKHQKVEDPRFYYWADRMGFLVWGEMANAYEFDTDYVERFTSEWIEAVKRDINHPSLITWTPLNESWGVSDLKHNVEQRNHVRALYFMTKVLDPSRPINDNCGWEHVQTDLTTFHDYGDSTDLGAACATMTAILELKGGHEVFTKPISLYAGSLIVDKGAQHTPGAPVICSEFGGVNIAPPKDSPAAGERDWGYTTATDPADFLVRFKKLVMAVVQPGHICGLVWTQLCDVEQEVNGLYTFDREEKVPAEKVKEIMDAAKDHYYRHTTSHSKGFRKLLDQTKHFVNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W6QCS6</accession>
    <name>W6QCS6_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Putative transcription factor kapC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">kapC</name>
        <name evidence="11" type="ORF">PROQFM164_S03g000979</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Putative transcription factor.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the bZIP family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="Proteomes" id="UP000030686">
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AP-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621">
        <property type="entry name" value="TRANSCRIPTION FACTOR KAPC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TRANSCRIPTION FACTOR KAPC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
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        <location>
            <begin position="103"/>
            <end position="118"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
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        </location>
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            <begin position="233"/>
            <end position="276"/>
        </location>
    </feature>
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            <begin position="1"/>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
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            <begin position="239"/>
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        </location>
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            <dbReference type="ARBA" id="ARBA00004049"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="276" mass="29904" checksum="8739763555200129" modified="2014-04-16" version="1">MQPALAPAPHPSMQTSAQDHADQVLHDQLLAAQHHLGGRPQGAPGQQQHLQPNNASPRDQPNIDPAISGAMLGAPQTPTQPQGSPPSDGGSKSYGKRELSTSKRAAQNRAAQRAFRQRKETYIRKLEEEVKNIDPLKEQVKSLVGENYQLREYIINLQSRLLEAQGEVPELPANIDLSQPRTTEMALASAGIQNSSPPGSVPTPGAQGQHSSVSDDMNSLNRIAAATLGMRKHPDDTAFLNNNSFQQNKRVRTDDSQDGNDGVNKQEIPHGLPMVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
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        <lineage>
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        </lineage>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
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                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
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                <person name="Lacoste S."/>
                <person name="Sallet E."/>
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                <person name="Brygoo Y."/>
            </authorList>
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            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
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        </source>
    </reference>
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            <end position="63"/>
        </location>
    </feature>
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            <begin position="39"/>
            <end position="61"/>
        </location>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CDM34260.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="78" mass="8715" checksum="5CEF9601F859C9AD" modified="2014-04-16" version="1">MLAAQKQAEIIHNVSGALDKYESKLSEINLKAIYRSGPTPNFHSESIAPTTTSANFSSHSGMDTRLTEKRMELKRHLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W6QCZ7</accession>
    <name>W6QCZ7_PENRF</name>
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        <submittedName>
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    </protein>
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    </gene>
    <organism evidence="3 4">
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
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    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
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                <person name="Branca A."/>
                <person name="Abraham A.L."/>
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                <person name="Lacoste S."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
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        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CD2BP2/Lin1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR035445">
        <property type="entry name" value="GYF-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13138:SF3">
        <property type="entry name" value="CD2 ANTIGEN CYTOPLASMIC TAIL-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13138">
        <property type="entry name" value="PROTEIN LIN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02213">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        </location>
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        </location>
    </feature>
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        <location>
            <begin position="304"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM27477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="443" mass="49700" checksum="0E0755F9816FFE2E" modified="2014-04-16" version="1">MSSSLPRPKRAGEDFANTHYNDDGEDSSEHKKPRFDLRNPSALAADAPEEDAVLDADEIGRRGQRIRRKAVNLEGYDSDSENEGFSARREEKPIRKQAKEDAEDDDMFAELQEDFGEEEVDGDEIINKKKSVRFLRDDEIEGQVASSKGGGALHVDLSKGAAEIDEEEDGSDSEVGEEERARIDEVVDEELGAGGKKKHAPLLDAFNMRTEQEEGRFDDQGNYVRKAVDPDAAYDSWLEGVSKKDIKKAKEAAEQRDAERKEKDRMDDSVLTADALKTIITHLERGETTLEALARLGKGLHRKPKWQNKKNKKKNAVEDVEMTDENPNELARKKAIDSITGAADILMGRGQIDIYDTEREMLTRQYRNDTGEDWIDPPAEGMTEQGPAMWEYRWSDARDGGDAHGPYDSAMMDSWKNAGYFGEGVEFRQVGDVGQWSGTVSFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W6QD43</accession>
    <name>W6QD43_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S03</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S03g001337</name>
    </gene>
    <organism evidence="2 3">
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QD43"/>
    <dbReference type="OMA" id="VAKKPMG"/>
    <dbReference type="OrthoDB" id="5331396at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37849">
        <property type="entry name" value="YALI0E11605P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37849:SF1">
        <property type="entry name" value="YALI0E11605P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM34613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="106" mass="11587" checksum="19513854DFACBBA6" modified="2014-04-16" version="1">MPIGTKIFLPLRGRVGIRSFSSSGARWESTALPASKPVGAFRGGVFGFLTGSVAAGALVYYYILTEYRLANETLSEDIAALQKATMKLQTYITELESRVDTLHKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W6QD89</accession>
    <name>W6QD89_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl transferase, family 54</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g001378</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QD89"/>
    <dbReference type="OrthoDB" id="2016523at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22189">
        <property type="entry name" value="PGAP4-like_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029675">
        <property type="entry name" value="PGAP4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31410:SF1">
        <property type="entry name" value="POST-GPI ATTACHMENT TO PROTEINS FACTOR 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31410">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="262"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="295"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM27567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="444" mass="50014" checksum="C2EDFB6CF1A0517E" modified="2014-04-16" version="1">MLVNRLVPTLGLSAISSVKGLRTFLFFLLSYALLFVVARRQSFRDPTSIFFDAMNAYDPVYSAIRLEQAASFIDAASNAAAPQITRAPRQPHFCLGIATIARKGARYFKDTVGTLLEGLSEEERADIHLILFIAHTDPSQHPAFAEPWLHKLADQVLLYNASEIDINHIRSLETNEAKIAGREKALFDYTYLLKACATVDTPYVIMLEDDLVALDGWYHRTVAALSSAEEQTRETGAANWLYLRLFYTEEFLGWNAEEWLNYLLYSILVVCFVACVLLIFRKLNPYTRSFLPNTIVVILSGVFTPLLIGLFFAAGRVTMLPPSRGVYQMPKFGCCSQAFVFPRSRIPELVELYTSKHIGYVDMLTEEYANARNEIRWAVTPSIVQHVGRKSSKGGDDDDILPPRKVKSKSQLTVAERLWNFGFEMNDAEALRAEHDAAKERAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W6QDC5</accession>
    <name>W6QDC5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S03g000790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QDC5"/>
    <dbReference type="OMA" id="QRARHFP"/>
    <dbReference type="OrthoDB" id="4506111at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="341"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="586"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="692"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="59"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="97"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="367"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="432"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="442"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="530"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="713"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="731"/>
            <end position="748"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM34066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="748" mass="82517" checksum="99DCC8A0EB5077EC" modified="2014-04-16" version="1">MVATRSTTAGTRPKAQPLLAKPSKAAKAVKTAKVAKMKAEKEAERAAAKAEKDAKKAAAKISKVAKTKNGTKGTKRTTAAKTKAIKATKTAKKAKATKSSVSAATVKASTKQYHEDEDEESEEDNYEPQAKRRKVKTLVPNVEIGRPTFKRPASKIGKWAYMEKLRVPEGVEDKYHGPLPPIYIGGAAPQPRWVIIQSENSANIKVPSKQHASKASSGRTGGARDFGELQWTFEEGDFKNWTGIEYPALYELAYLCLEYTLTHTELREQIYDSLAQGPLLKAVAIDPVLPPVPITRHFATGTSEQSSRKSSNAAFYFPNYDRPSMAVRPRDDRMARPYPHAVASNIYNRPRSEEWPTASRSASPDPESERGGKQGSEESHTAEPRKSQDPEGTYSEPAAPAPFRNDEKVSCVTISEDGSIFGDGDDVQTEPHSARDSREQSPDSLLSGSGSNSEVSASSKTSEPGKVNTADDNSDQSTNNLSPVSHDGLFSPGQIERYYRKKQKNFERLGGVGHREASKRKRRAQLSLEDAQKEARKRELEIIGAPKSSKRIRMESPSIPSPSAVRRKTAAEITVDKVMSFARAEQDKRDEMRAAAAEKISDRPPVALKKPIGNQAGATPQADAPSPEIPPNLQDRFLEQIRIYLNDPMRRARHFPDPIAVRRARVWAGEELVGHEIKPEVDATLPPWAERNRPFSQWQDPIGEIPTPAARTKLLRSKRRSKGRGKRRPRPASAAEQSVSSAQWSSFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2024-10-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W6QEG9</accession>
    <name>W6QEG9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S03</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S03g001587</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QEG9"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM34860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="87" mass="9394" checksum="A5DE420F9B1B1C48" modified="2014-04-16" version="1">MDHSTFALAIKTDSTEPRDSVGNENAPYGVLIEASPLAAKPAKNSRNAAGTYLVSRALLEKKGWNVCRNNTFIHSAFFARIATGTHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>W6QEI0</accession>
    <name>W6QEI0_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10 13">Catalase</fullName>
            <ecNumber evidence="3 10 13">1.11.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">catB</name>
        <name evidence="17" type="ORF">PROQFM164_S03g001597</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the degradation of hydrogen peroxide (H(2)O(2)) generated by peroxisomal oxidases to water and oxygen, thereby protecting cells from the toxic effects of hydrogen peroxide.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 13">
            <text>2 H2O2 = O2 + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:20309"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="EC" id="1.11.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10 12">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 10 13">Belongs to the catalase family.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.6" evidence="3 10 13"/>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QEI0"/>
    <dbReference type="STRING" id="1365484.W6QEI0"/>
    <dbReference type="OMA" id="YGDWSNI"/>
    <dbReference type="OrthoDB" id="6880011at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004096">
        <property type="term" value="F:catalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070301">
        <property type="term" value="P:cellular response to hydrogen peroxide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03132">
        <property type="entry name" value="GATase1_catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.180.10:FF:000003">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000043">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1370.20:FF:000001">
        <property type="entry name" value="Catalase HPII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1370.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.180.10">
        <property type="entry name" value="Catalase core domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018028">
        <property type="entry name" value="Catalase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024708">
        <property type="entry name" value="Catalase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024712">
        <property type="entry name" value="Catalase_clade2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043156">
        <property type="entry name" value="Catalase_clade2_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011614">
        <property type="entry name" value="Catalase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002226">
        <property type="entry name" value="Catalase_haem_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010582">
        <property type="entry name" value="Catalase_immune_responsive"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041399">
        <property type="entry name" value="Catalase_large_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020835">
        <property type="entry name" value="Catalase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42821">
        <property type="entry name" value="CATALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42821:SF3">
        <property type="entry name" value="CATALASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00199">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06628">
        <property type="entry name" value="Catalase-rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18011">
        <property type="entry name" value="Catalase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038927">
        <property type="entry name" value="Catalase_clade2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00067">
        <property type="entry name" value="CATALASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01060">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56634">
        <property type="entry name" value="Heme-dependent catalase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00437">
        <property type="entry name" value="CATALASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00438">
        <property type="entry name" value="CATALASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51402">
        <property type="entry name" value="CATALASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10 13" id="KW-0349">Heme</keyword>
    <keyword evidence="9 10 13" id="KW-0376">Hydrogen peroxide</keyword>
    <keyword evidence="8 10 12" id="KW-0408">Iron</keyword>
    <keyword evidence="6 10 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 10 13" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004879778" description="Catalase" evidence="15">
        <location>
            <begin position="17"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="domain" description="Catalase core" evidence="16">
        <location>
            <begin position="56"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="102"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="12">
        <location>
            <position position="389"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR038927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR038927-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR038927-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM01060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CDM34870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="727" mass="79362" checksum="2AE6E57C83ABF595" modified="2014-04-16" version="1">MRVLALVTGLVGIANAACPYMTGEAGPLERRGDGDASSTEEFLSQFYLKDQDVFLTSDVGGPIEDQNSLSAGERGATLLEDFIFRQKIQRFDHERVPERAVHARGAGAHGTFTSYGDWSNLTAASFLSAKGKQTPMFTRFSTVAGSRGSADTARDVHGFATRFYTDEGNFDIVGNNIPVFFIQDAILFPDLIHAVKPRGDSEIPQAATAHDSAWDFFSQQPSALHTLLWAMAGHGIPRSFRHVDGFGVHTFRLVTDDGKTKLVKFHWKGLQGKASFVWEEAQQTAGKNADFMRQDLFEAIEAGRFPEWELGVQIMEEDDQLRFGFDLLDPTKIVPEELVPVTKLGKMQLNRNPLNYFAETEQVMFQPGHIVRGVDFTEDPLLQGRIFSYLDTQLNRHGGPNFEQLPINRPRVPIHNNNRDGAGQMFIPLNPNAYSPNTENNGSPKQANQTVGNGFFTAPDRTSSGKLQRTVSSTFEDVWSQPRLFWNSLVPAEKQFIVDAIRFETSNVKSSVVRNNVIIQLNRISNDLATRVAKAIGIDAPKPDPTFYHDNTTAHIGAFGQKLAKLDGLKVGLLASVDKPASIAQGAKLQSALSAVGVDVVVVAERFADGVNQTYSASDAVQFDAVVVADGAEGLFASKSITSVPNKASGASSLYPAGRPLDILLDAFRFGKTVGALGKGSAALRSALISTDRDGVYTASNAGSAFVKDIKEGLRTFKFLDRFALDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W6QEZ9</accession>
    <name>W6QEZ9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized conserved protein UCP014753</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S03g001772</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM35045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QEZ9"/>
    <dbReference type="STRING" id="1365484.W6QEZ9"/>
    <dbReference type="OMA" id="SPYWCCK"/>
    <dbReference type="OrthoDB" id="5150166at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049237">
        <property type="entry name" value="DUF2264_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049349">
        <property type="entry name" value="DUF2264_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016624">
        <property type="entry name" value="UCP014753"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35339">
        <property type="entry name" value="LINALOOL DEHYDRATASE_ISOMERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35339:SF4">
        <property type="entry name" value="LINALOOL DEHYDRATASE_ISOMERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10022">
        <property type="entry name" value="DUF2264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20938">
        <property type="entry name" value="DUF2264_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF014753">
        <property type="entry name" value="UCP014753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2264" evidence="2">
        <location>
            <begin position="21"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2264" evidence="3">
        <location>
            <begin position="376"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM35045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="646" mass="72168" checksum="B49269FC88515855" modified="2014-04-16" version="1">MSIHANGRTPSQAFSKSPFRTRSDLQEACRAILNPLVPLFTPGGTRVKVGTSTTRFDEGGAQIEGYARPLWGLASLLGGGYEYGEAERWRQGIINGTDPEHPEFWGHIEDMDQRMVEMCPIGFALAVAPHVFWDPLTAKQRGNVGRWLASINAREMPNTNWLWFRVFANLGLRKNGAEYSSSRIEADMDHLDTFHVGGGWSNDGPKSHHQMDYYSGSFAIQFLQLLYSKLAGEFDPERAERYRQRAREYATDFVHYFDPNGSAIPFGRSMTYRFAMVGFWGALGFADVELPEPLTWGVVRGIILRHFRWWSTQDDIFHNDGTLSLGYSYANMYLTENYNSPGSPYWCCLSFTPLALPETHPFWSAQEEPYPNSSLPEVVALKYPKHIAIRRGGHSFLLSSGQACHYPLKATQAKYGKFAYSSAFGYSVPTGGYQLEQHAPDSMLALSDDGGDIWQTRRLALDARFEEPEPNGQPILVSGWKPWPDVDIETILIPPTAETENWHLRAHHVRTGRALQTSEGAFAIYGCRSDNGRTLGPMAENDSEGTIHDSRSGLVVSSAGAVGIAELHSAIGRVGRIVLADPNSNIIHGRTLLPSLAVDLAAGQDCWFVSAVYAVPDRQRDWKAAWEKKPVIPEWLRKRMESAEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W6QFL2</accession>
    <name>W6QFL2_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PROQFM164_S01g002223</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RBT5 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QFL2"/>
    <dbReference type="STRING" id="1365484.W6QFL2"/>
    <dbReference type="OMA" id="CTETHAC"/>
    <dbReference type="OrthoDB" id="5431405at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008427">
        <property type="entry name" value="Extracellular_membr_CFEM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05730">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004880174" evidence="10">
        <location>
            <begin position="21"/>
            <end position="1163"/>
        </location>
    </feature>
    <feature type="domain" description="CFEM" evidence="11">
        <location>
            <begin position="937"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="90"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="264"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="471"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="581"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="715"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="273"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="474"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="581"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="730"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="751"/>
            <end position="763"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDM28412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="1163" mass="112498" checksum="93771C2A5ED80346" modified="2014-04-16" version="1">MKVTSAIVFLSLLASGQATGASWGSEKCYSSPGRSPNKCNDSQQKGFSWTDLAPGSFSSYGGFSFSGFTCGNGFGSSLGKRGTQKCISGTVSKGSSSSSSSSSGSSGSSSHSSSGSGSSSSSSSSSSAPSFSCGSDESGFSVTNFHVATDKDTDLHIIYSMPDGSTCKNTASCNSAGTVVSNDQCGGATSVHFELPDDSEHESCGLGIYSVGFDCTPGSTTTAPVVSSTSAITRVPSEQTSVSSSIVVPSLSVPGSVPGSAVTSSTAVPSLSVPGSTPGSAVSPVTTPAVSTPVQMTTSTVFTTSLITITSCAPTVTNCPAGSTVVVTSTIALSTTVCPVTETTATATSSLSVPAVSSPSGVSPVSSSAGIPGVASGTSVPGSSILPSSAISSTAGETPDVTSATSTPVITTPVQMTTSTVYTTSLVTITSCAPTVTNCPADSTTVVTSTIPISTTVCPVTETTTGAVGSTPLSAVPSPSGVSPVSSSAGIPGVPSGTSVPTSSIPASSVSSAPGETPVGTSAASTPVITTPVQMTTSTVYTTSLVTITSCAPTVTNCPAHSTTVVTSTIPVSTTVRPVTETTTAEVGSTPLSAVPTGVSPVSSSAGSPPASGTSAGTPSAPSVTSAVSSPAGTPLAPGEATTTVVTWETVTTCPVTNTVTSGSSTFVTTSSTISTVTMTSVSTICTDCSATATSVAGQSTVAPSGTPGVSIIVVSSTGSSDTPGASSLVPSGTSEGSSPVSSSSAEASSPLPTGSDVTSLVPTGVSAETTPAIPQGSTATVVTYVTETTCPVTATVTSGSSTFVTTSSTVSTVTLTSTSNLPSSVAAGSTPAPSETGVAATTAPAVTSANSTPTIPEGATTTVVTYVTETTCPVTNTVTSGSSTFVTTSSTVSTVTLTSVATIATTATAATESQSTSVVPSGVSPVSSPAPSAPCPNTVPQCINTWLSLAPKCTSNSDASCFCPNSEFTSKVISCIQAWGASKSEIQSALSYFTGICATWVPQNPGIVTAIPSTITLIPTVAPSVPASAAGVTGATVTAPASVVIPITSAPALPVTTITYSTYTVTVPQVSFVTNTGSTAGAVPTIGLVPAAPSGTSPANTGVVPAPASATWATSSGYAYASRSASGVVSPSASPIFNAASSVSVASSLLLASLAAFFGLMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W6QFN5</accession>
    <name>W6QFN5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S03</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S03g001473</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QFN5"/>
    <dbReference type="OrthoDB" id="4364540at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM34746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="93" mass="10709" checksum="B426A772E9354925" modified="2014-04-16" version="1">MAKFKSRVSNTESCVDRAAALNFRIRQFAEPIVEMSLSFWRKWPTLYGEMVVHGPPPYKNCPPQQFLATCTAHCIFTPQMWSVGMCRRGRGPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W6QFP0</accession>
    <name>W6QFP0_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ENTH/VHS</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S03g001483</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QFP0"/>
    <dbReference type="STRING" id="1365484.W6QFP0"/>
    <dbReference type="OMA" id="KPSWQYN"/>
    <dbReference type="OrthoDB" id="5393057at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21383">
        <property type="entry name" value="GAT_GGA_Tom1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004152">
        <property type="entry name" value="GAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038425">
        <property type="entry name" value="GAT_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03127">
        <property type="entry name" value="GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89009">
        <property type="entry name" value="GAT-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50909">
        <property type="entry name" value="GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GAT" evidence="2">
        <location>
            <begin position="213"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="303"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="7"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="310"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="346"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="370"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="408"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM34756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="425" mass="47110" checksum="1AF4E7F83259CF5F" modified="2014-04-16" version="1">MKRFLGSLSRRSSSSDSVEYSEDSPEAVVLQALTAFCESNQNVNADGSSHDAQGTEFVYLPQIVETAESSPNAAKEAALRIRKYLTDPAGTPNHTQYNAIMLMRILADNPGHTFTRNFDAKFVTTVKELLRTGRDWNVQSYLRQYLDSLEQERAWDEDLKLLLQMWAKEKTKASHGLIDRFPRNSVVPPRVPPRSRPHQQPYGLSRAPTNTLPTPVELAARIEEARNSAKLLTQFVQSTPPIELEDNDLIKEFVDRCTTGSRVVQGYIHATNPAPDEDTLLTLIETNEEISVALSQQQRAMLKARKIRGSSSPSSSNLNSPSPTSQVVAPGVTNFSPPPVAPAGISTRSSESPAQLPSPTMTGGRPLASHSLNSNPVGGSTTNSRYEYKPEDFQVRNPFADDYATNESEERNRVHFDSQVQSDRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W6QG38</accession>
    <name>W6QG38_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Diphosphoinositol polyphosphate phosphohydrolase aps1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">aps1</name>
        <name evidence="6" type="ORF">PROQFM164_S04g000251</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM164</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QG38"/>
    <dbReference type="STRING" id="1365484.W6QG38"/>
    <dbReference type="OMA" id="EDQWPEM"/>
    <dbReference type="OrthoDB" id="2011998at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034431">
        <property type="term" value="F:bis(5'-adenosyl)-hexaphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034432">
        <property type="term" value="F:bis(5'-adenosyl)-pentaphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008486">
        <property type="term" value="F:diphosphoinositol-polyphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000298">
        <property type="term" value="F:endopolyphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901911">
        <property type="term" value="P:adenosine 5'-(hexahydrogen pentaphosphate) catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901909">
        <property type="term" value="P:diadenosine hexaphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901907">
        <property type="term" value="P:diadenosine pentaphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071543">
        <property type="term" value="P:diphosphoinositol polyphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04666">
        <property type="entry name" value="NUDIX_DIPP2_like_Nudt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000046">
        <property type="entry name" value="Nudix/MutT family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047198">
        <property type="entry name" value="DDP-like_NUDIX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12629">
        <property type="entry name" value="DIPHOSPHOINOSITOL POLYPHOSPHATE PHOSPHOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12629:SF0">
        <property type="entry name" value="DIPHOSPHOINOSITOL-POLYPHOSPHATE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="5">
        <location>
            <begin position="22"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDM35370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="158" mass="17657" checksum="CF32F774A8B46417" modified="2014-04-16" version="1">MAQIRSMEARVGRKNQRYGSKGERLVAGVVPISADKTKVLMIQSAGPGGWVLPKGGWELDEKTAEQAACREAWEEAGVICVVTRDLGLIPDMRPSGLLTAHAPKASYQFFEVTVQQEETEWPEMHKRKRQWVSYTQAATALANRPELLEALHRSSLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W6QGA9</accession>
    <name>W6QGA9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S02g003376</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM33224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QGA9"/>
    <dbReference type="OMA" id="EDNIPFE"/>
    <dbReference type="OrthoDB" id="2520703at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM33224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="438" mass="50920" checksum="552F5BF17F56649C" modified="2014-04-16" version="1">MDRLPNELLLAIGKHAQEDGCAQSTLHSLSLTCRRFHDLFSPLMYSYISSDNFTESFIGLIMRMWRQPELARQVHRLDLCWSQCDQHDPLEMNDEMQSFIKHALEDIFTTEEQEQKELWTEHLHGEEGICGEAWLGLFLVRLTNLRILEFQHEHSDLVSEILLKAAKRQQPFHHEPPFPHLKEVRACVAWGVSWIDSGFVEPFFYFPQVRKIYGTAIGEKKDEDMDLKSYQDVCPVQDITVEEGYWCRGMLDWLAVCTHLEHISIRVEIQADEYDLDEEKQFDASKFRLALLPFTTTLKTLRIGYGDAYKDQVVAEKDVVENPFGSFKDFNVLETLKVRHDHLMKSPDNSILNWDMKPLTEILPHCLVNLEITDIMFDYHLELSSQLLKLLRAVNFSVNLRKLKLGIFLADGEELGDVFDDLKLECQVANVCLKIEIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W6QGZ4</accession>
    <name>W6QGZ4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Genomic scaffold, ProqFM164S03</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S03g000188</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QGZ4"/>
    <dbReference type="OMA" id="SCCPFGY"/>
    <dbReference type="OrthoDB" id="5338512at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004880219" evidence="3">
        <location>
            <begin position="24"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="229"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="342"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="151"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="349"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="366"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="432"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM33464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="443" mass="47119" checksum="C4846C238D25336C" modified="2014-04-16" version="1">MTRSRPSVLLLFTLMASIQPGLAYSSFDLLSRSSDACPSSFSRCGGTKLPNDFCCPSDSTCISLDQGSSSICCPAGKDCDYISPITCDIQLQNVTIYPESVIKTTRLGDSLPKCGDACCPFGYTCQGDNTCSLNQKTSTTATEALSSSSITTTSSSVSSSSTNTDSSSTTATTSTISQATITPVPSPSSTTGTTSTIPQETITPVPSPSSEKSTNSTTCSALSTSCPSFPAGALAAGFFPGAVLGAVAALLITFCFRRARKDECEIQEGKNGPNWSQRSSSGARLCISNPIPQDDTSYRTDFLRCPPRAKRSSIGGRSTRTVIHRTGSRVRSLFSGYPRQTARLDKDVPPIPMPNPMHPAPFTPPRQRQPSTESITVYSPPESWLSQSRTLLGPSPYPGDTARPDTLFSDLMRVVGSPHDGKGKPPYPTNDNSRENPFRDPVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W6QH30</accession>
    <name>W6QH30_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">endo-1,4-beta-xylanase</fullName>
            <ecNumber evidence="4">3.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PROQFM164_S04g001019</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-xylosidic linkages in xylans.</text>
            <dbReference type="EC" id="3.2.1.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycan degradation; xylan degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 10 (cellulase F) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.8" evidence="4"/>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM36138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QH30"/>
    <dbReference type="STRING" id="1365484.W6QH30"/>
    <dbReference type="OrthoDB" id="3485856at2759"/>
    <dbReference type="UniPathway" id="UPA00114"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031176">
        <property type="term" value="F:endo-1,4-beta-xylanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001000">
        <property type="entry name" value="GH10_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00331">
        <property type="entry name" value="Glyco_hydro_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0858">Xylan degradation</keyword>
    <feature type="domain" description="GH10" evidence="9">
        <location>
            <begin position="89"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDM36138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="181" mass="20550" checksum="2EC309B629622704" modified="2014-04-16" version="1">MRMLDTDEILQCYVEDKIVTIIIQAFPVYLPECLPSPLHKNFFAELVWEISSQLRVLQRRDELAEYVEEAKVPSVSSAIGPPVYKYTNSDCDTVDNLRKRGIRINAVGLKSHFVVGQTLSLADQLATKKAYIKADLDVIITGLDIRFAEEPYYTANMQEQQAADYYLDVQRCLQAGHSCLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>W6QHE4</accession>
    <name>W6QHE4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Histone-fold</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PROQFM164_S01g002848</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QHE4"/>
    <dbReference type="STRING" id="1365484.W6QHE4"/>
    <dbReference type="OMA" id="DIVQCSG"/>
    <dbReference type="OrthoDB" id="636685at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008623">
        <property type="term" value="C:CHRAC"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23645">
        <property type="entry name" value="HFD_Dpb3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050568">
        <property type="entry name" value="Transcr_DNA_Rep_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252:SF54">
        <property type="entry name" value="CHROMATIN ACCESSIBILITY COMPLEX PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252">
        <property type="entry name" value="HISTONE-LIKE TRANSCRIPTION FACTOR CCAAT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor CBF/NF-Y/archaeal histone" evidence="4">
        <location>
            <begin position="18"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="112"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="153"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="171"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDM29037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="187" mass="20383" checksum="B8C094B4B7E173F0" modified="2014-04-16" version="1">MAPKTVGEPDEITGQSALPIARIKKIIQLDEDIVQCSNNATFVIAMATEMFIQYLAEQGHNVVKSERKPRKTVQYKDLASAVSHTDNLEFLSDVIPKTTTYKQFKEKKAKDAANQGAIEKGQRTLNGTIAPPTPANGTVMGDATPQKEDSKTSSPSVSRPMVPVSALIADRTVEPMATHDQDVEMQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W6QI05</accession>
    <name>W6QI05_PENRF</name>
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        <submittedName>
            <fullName evidence="3">EEIG1/EHBP1 N-terminal domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S03g000533</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QI05"/>
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    <dbReference type="OMA" id="WNNDAHN"/>
    <dbReference type="OrthoDB" id="3365224at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039931">
        <property type="entry name" value="EEIG1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019448">
        <property type="entry name" value="NT-C2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21456:SF1">
        <property type="entry name" value="C2 NT-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21456">
        <property type="entry name" value="FAMILY WITH SEQUENCE SIMILARITY 102"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10358">
        <property type="entry name" value="NT-C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51840">
        <property type="entry name" value="C2_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2 NT-type" evidence="2">
        <location>
            <begin position="3"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM33809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="349" mass="39332" checksum="43A95E95024509AE" modified="2014-04-16" version="1">MQAFVPKNRRPRFELILRIIDINNVPLGNSVAFVRWRLPSSSSTEHQGYTEKATLLDHRAYWGYEKCLQVRLTIDRTSILQECELNFEVIQEFTSSPMSEKSVLGKIKLNLAEYVEKTEEDEGIIRRYLMHESKVNSTVKIGIAMRQLEGDRNFTTPHLKSATVFGGIAGVVQSTDQPVNADEFGQLPSIDSKSRETADMQDMYRRTLAASWSSRAGDLPADQLVEELFAGSSCWNNDAHNSHAGISAGDRRDILLTTETAPRQSRSGKKLSPSFERRPKSSSSNRSHRSSKTPESLAALGHQKKGGSIEQQLYEGVMGRAWKVPDTNNELSEFDVREDLRSWEVVPKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W6QI39</accession>
    <name>W6QI39_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S03</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S03g000573</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QI39"/>
    <dbReference type="STRING" id="1365484.W6QI39"/>
    <dbReference type="OMA" id="VWAMVTP"/>
    <dbReference type="OrthoDB" id="1744869at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM33849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="498" mass="53949" checksum="EBC908045A5D97E5" modified="2014-04-16" version="1">MSMRFKQMRVAFTSGRWQLLGSCKAPKSLGRANRWYATQNLTPDDILSSLPSGPVSPSAAPASVPLLLVTPSFAHWLDSSSPFLSQFLGRLYGNSPGNDTLYAVTAVVDAIPNTTSESRNLSESEGLSLLIVGQSGVQAKAAPPRLIRSSASEETNLLFSFQTDVIGQTSKGPAHEIGLRLANTIFVNGRETTIFGTRWLWDKTSNRYALDNSVDFTSCMLTATSQAVDSALELPLYPVTGRRRVMTSMGNILRQLAKSMDLTSTDTIPASSELEKELPRYIAEHNIVDQRVSVWALVEKPDSEVAGSGLSTHDRLIQSLHRGGKLHRVMSGGGGWGKKQGLLSLDPEVSFSGTANRDDLVALTQVLDPDIAQLDTLPSIDKGITVDDLSLLSQVATAGDYIQFFVSVEPTGSQIKVPSNHDLQEEPISYHFGMVADSMKLETHQTDEENNGIISLPHTFGALSEKAIAYSQPIKGETRSESCTKLDIPGSRVVLETV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W6QIB1</accession>
    <name>W6QIB1_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g003124</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QIB1"/>
    <dbReference type="OMA" id="ICSHVEC"/>
    <dbReference type="OrthoDB" id="4369595at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM29312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="119" mass="12919" checksum="883111268A67CFE7" modified="2014-04-16" version="1">MSNAMSNKSSNTGTNSEGQNSTPFSHGWHFTRPNNSSYADSMSSTLTSHAHSTLAPFPDAISVLTPTPECLSTSAQRLVPEWWTCCKCQNLVNPNLAPERKCPICSHVECDFCGTEVVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W6QIE2</accession>
    <name>W6QIE2_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">aldehyde dehydrogenase (NAD(+))</fullName>
            <ecNumber evidence="5">1.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PROQFM164_S05g000028</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>an aldehyde + NAD(+) + H2O = a carboxylate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:16185"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.3" evidence="5"/>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QIE2"/>
    <dbReference type="STRING" id="1365484.W6QIE2"/>
    <dbReference type="OMA" id="CREGIRM"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07090">
        <property type="entry name" value="ALDH_F9_TMBADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000014">
        <property type="entry name" value="NAD/NADP-dependent betaine aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000007">
        <property type="entry name" value="NAD/NADP-dependent betaine aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009725">
        <property type="entry name" value="PRK13252.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="9">
        <location>
            <begin position="20"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDM36195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="498" mass="53442" checksum="47F2BE18FF509184" modified="2014-04-16" version="1">MSLSFPPRQLYYDGKVQAATSGKSFQTINPATATPLADIQIASNADVDAAINAAHRAFPSWAQTPLIGRARILQKAAALLRERNDEIARVETLDSGKAYTETSTVDVTTGADVLEYYANFIGGGGLNGETTQLREDAWVYTKKSPLGVCAGIGAWNYPIQIALWKSAACLAAGNTMIYKPSEYTPLHGQTLAEIYTEAGLPDGVFNVINGAGDVGAYLTGHPLIAKVSFTGQVATGMKVAGTASGNMKYVTMELGGKSPLIVCPDAELESAVNGAMMANFYSTGQVCTNGTRVFVPRTMKAAFEKSLLEKIQYVRAGPLFDEQTNFGPLSSKAHYDKVVAYIRHGIESDRATLLCGGVEKPSVPKDLQAGFWVQPTIFTDCTDSMTIVKEEIFGPVMSILYYDTVEEAVRRANTTELGLAAGVFTKDLNQAHRVIDQLQAGITWVNTWGESPAEMAVGGWKKSGLGVENGRRGIEAWLQNKSTLVDMSGTVVSVFAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W6QIN2</accession>
    <name>W6QIN2_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S05g000083</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QIN2"/>
    <dbReference type="OrthoDB" id="4259138at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM36250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="77" mass="9015" checksum="C9C6FD80AF3F6CB5" modified="2014-04-16" version="1">MNLVQTNLQIIKNFLDRQTTTANIPYLFCNDKWLQKLQRSNVAKDVNRNDIFKYNSTTSDHLSPVSIKNIPSYQEIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W6QJ48</accession>
    <name>W6QJ48_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S05g000268</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QJ48"/>
    <dbReference type="STRING" id="1365484.W6QJ48"/>
    <dbReference type="OrthoDB" id="1668230at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM36435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="129" mass="14660" checksum="9FCE66FE0DFD69FB" modified="2014-04-16" version="1">MAITIGIYRHQYYLHGDVAKYCQESSITSELRSKWFQQILEAVVFFIDDNSDLRLGDFNSSQCPGHISPHCLPQDYELPNTETSDIFALESTLYEQVAGKAPYSELSRPKSDDLDIIKSSNLKTTYGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W6QJI5</accession>
    <name>W6QJI5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S03</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S03g001088</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QJI5"/>
    <dbReference type="OMA" id="IMVWLEL"/>
    <dbReference type="OrthoDB" id="3205825at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35179:SF1">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35179">
        <property type="entry name" value="PROTEIN CBG02620"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM34364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="288" mass="32876" checksum="B2C9D8C3F64CDE07" modified="2014-04-16" version="1">MITLLSPHFVLPAVSEDDMVIASLAWGFTIGFGWLTTWTAVKQTLHIYKRHGRHIFHNAYVWMIWLEILVCLIFSVLCWLYLRGTIPPSFAFYFCIVTTWALQVQFLLQIIINRCAILLVDRRNANRLKVGVAILITAINISVYAIWIPARLQISETYIRVNDRWDRCEKVIYLLVDGALNFYFIRIVRSSLVSAGLGKYKTLVHFNIGIIGLSLGMDVLIISMMSLNNTFVYMQFHPLAYMVKLNIEMSMADLIGRIASDRSSVIICNDTLELAGAGDTQEVRFVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W6QJJ2</accession>
    <name>W6QJJ2_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S05g000014</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QJJ2"/>
    <dbReference type="STRING" id="1365484.W6QJJ2"/>
    <dbReference type="OMA" id="QISLHCE"/>
    <dbReference type="OrthoDB" id="5365739at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="34"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="232"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="83"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM36181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="343" mass="38181" checksum="6C3DE20A36B4DEFB" modified="2014-04-16" version="1">MFRPQLRQISLHCERTKLGLSTPARQFSCTRTVAAENRAQPSDNRKPNPRSSSATLSYRPRNPNGPPARTNQYQTRPPRVIDARSFAAARASGGEQPKIIRSPRSRDIRGGNQPQNRKPKPFAKGAKGNRNGPRRNAKTPENDDGEDGEAAAIDQILQEQIIKSRPTPIRYEPQEISYSTLKETWPSIPTDVNSRSAAVYEKLSSLGGRIANGYIPPYELGRRLWKGQSVLFNNENEKAEALEETKRLAQLRADRISQRKGDLVEPRNVEFSPIDAESTKSLMETFVQGNYPTSEVGKDGHAVLGEVLKNLRNNGTYQTTGKTSQFMAKIESLVSAGRKTKSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W6QK63</accession>
    <name>W6QK63_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S02g000116</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM29967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QK63"/>
    <dbReference type="STRING" id="1365484.W6QK63"/>
    <dbReference type="OMA" id="YRHEGER"/>
    <dbReference type="OrthoDB" id="3360421at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM29967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="146" mass="16827" checksum="93DA06D142BCCF4E" modified="2014-04-16" version="1">MPPKEKYTDPELRDEIKKEVHNSDKGGKPGQWSARKAQMMASEYKKRGGGYNTTKEEGQTESQKHLDNWTKEEWQTKEGSGTARQDDDSRKRYLPKKAWENLSEKEKDETDEKKVEESQGGKQFVSNTAKAKEARRRASSDVEDES</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>W6QKT1</accession>
    <name>W6QKT1_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tripeptidyl-peptidase II</fullName>
            <ecNumber evidence="4">3.4.14.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">sed1</name>
        <name evidence="15" type="ORF">PROQFM164_S06g000015</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Secreted tripeptidyl-peptidase which degrades proteins at acidic pHs and is involved in virulence.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal tripeptide from a polypeptide.</text>
            <dbReference type="EC" id="3.4.14.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="12">Binds 1 Ca(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
            <location evidence="3">Extracellular space</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.4.14.10" evidence="4"/>
    <dbReference type="EMBL" id="HG792020">
        <property type="protein sequence ID" value="CDM37055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QKT1"/>
    <dbReference type="STRING" id="1365484.W6QKT1"/>
    <dbReference type="OMA" id="ACREYHV"/>
    <dbReference type="OrthoDB" id="409122at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008240">
        <property type="term" value="F:tripeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04056">
        <property type="entry name" value="Peptidases_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11377">
        <property type="entry name" value="Pro-peptidase_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015366">
        <property type="entry name" value="S53_propep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030400">
        <property type="entry name" value="Sedolisin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050819">
        <property type="entry name" value="Tripeptidyl-peptidase_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14218">
        <property type="entry name" value="PROTEASE S8 TRIPEPTIDYL PEPTIDASE I CLN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14218:SF19">
        <property type="entry name" value="SERINE PROTEASE AORO, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G10250)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09286">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00944">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51695">
        <property type="entry name" value="SEDOLISIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10 12" id="KW-0106">Calcium</keyword>
    <keyword evidence="8 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 12" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 12" id="KW-0720">Serine protease</keyword>
    <keyword evidence="7 13" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004881726" description="tripeptidyl-peptidase II" evidence="13">
        <location>
            <begin position="17"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S53" evidence="14">
        <location>
            <begin position="222"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="12">
        <location>
            <position position="298"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="12">
        <location>
            <position position="302"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="12">
        <location>
            <position position="559"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="600"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="601"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="619"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="621"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CDM37055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="642" mass="70061" checksum="F84539AE87D1A0F8" modified="2014-04-16" version="1">MRSFIVLCALSASVMAVPRAHNYQLHERRDFIPKSWVEGKKLEGNVSLPVRIGLTQSNLDYGHELLMDLSNPYSSRYGQHLSIREVHDLFAPTEQSVNDVRSWLESTGIAKDRITQSANKQWIQFDADAKELENLLDTEYYIYSHAETGRSHVACREYHLPSSVREHVDYVTPGISMREVTGVRRSTEKQKRVVDGAPPIIEPILIPIEELLSEASSFCSRVVTPQCIQQMYNISEGHSATKGNELGVFEGTGDVYAQEDLDLFFSNLYSKIPHGTHPTLKSVDGGQAPTDSFNAGAESNLDFQISYPIIWPQNSVLFQSDDMHYENHYTFNGFLNTFLDAIDGSYCSTISPLDPPYPDPADGGYKGSLQCGVYDPPKVISISYGSAEADLPISYQRRQCAEFMKLGTMGVSVVVASGDSGVAGRGGDPTPSNCLGPDGRIFTPDFPASCPYLTAVGGTEIPTGSAPGDHKEQAVSRYPSGGGFSNIYKAPDYQAQAVADYFDKAKPSYPYYESVDNSSFGENNGIYNRIGRAYPDVAAIGDKVIIYYRGIAVSIGGTSASAPVFAGILTRINEERLAAGKSTVGFVNPVLYAHPEAFFDVTKGTNPGCNTEGFSATEGWDPVSGLGAPNYPELLRVFMGPE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2018-06-20" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W6QL00</accession>
    <name>IFGB_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">4-dimethylallyltryptophan N-methyltransferase ifgB</fullName>
            <ecNumber evidence="1">2.1.1.261</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Isofumigaclavine biosynthesis cluster A protein B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ifgB</name>
        <name type="ORF">PROQFM164_S05g000509</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>FM164</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2017" name="Appl. Microbiol. Biotechnol." volume="101" first="6111" last="6121">
            <title>Silencing of a second dimethylallyltryptophan synthase of Penicillium roqueforti reveals a novel clavine alkaloid gene cluster.</title>
            <authorList>
                <person name="Fernandez-Bodega A."/>
                <person name="Alvarez-Alvarez R."/>
                <person name="Liras P."/>
                <person name="Martin J.F."/>
            </authorList>
            <dbReference type="PubMed" id="28620689"/>
            <dbReference type="DOI" id="10.1007/s00253-017-8366-6"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>PATHWAY</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2017" name="Org. Biomol. Chem." volume="15" first="8059" last="8071">
            <title>A bifunctional old yellow enzyme from Penicillium roqueforti is involved in ergot alkaloid biosynthesis.</title>
            <authorList>
                <person name="Gerhards N."/>
                <person name="Li S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28902217"/>
            <dbReference type="DOI" id="10.1039/c7ob02095c"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <comment type="function">
        <text evidence="2 3">4-dimethylallyltryptophan N-methyltransferase; part of the gene cluster that mediates the biosynthesis of isofumigaclavines, fungal ergot alkaloids (PubMed:28620689). The tryptophan dimethylallyltransferase ifgA catalyzes the first step of ergot alkaloid biosynthesis by condensing dimethylallyl diphosphate (DMAP) and tryptophan to form 4-dimethylallyl-L-tryptophan (PubMed:28620689). The second step is catalyzed by the methyltransferase ifgB that methylates 4-dimethylallyl-L-tryptophan in the presence of S-adenosyl-L-methionine, resulting in the formation of N-methyl-dimethylallyl-L-tryptophan (PubMed:28620689). The catalase ifgD and the FAD-dependent oxidoreductase ifgC then transform N-methyl-dimethylallyl-L-tryptophan to chanoclavine-I which is further oxidized by ifgE in the presence of NAD(+), resulting in the formation of chanoclavine-I aldehyde (PubMed:28902217). The chanoclavine-I aldehyde reductases ifgG and/or fgaOx3 reduce chanoclavine-I aldehyde to dihydrochanoclavine-I aldehyde that spontaneously dehydrates to form 6,8-dimethyl-6,7-didehydroergoline (PubMed:28620689, PubMed:28902217). The festuclavine dehydrogenases ifgF1 and/or ifgF2 then catalyze the reduction of 6,8-dimethyl-6,7-didehydroergoline to form festuclavine (PubMed:28620689). Hydrolysis of festuclavine by a yet undetermined cytochrome P450 monooxygenase (called ifgH) then leads to the formation of isofumigaclavine B which is in turn acetylated by ifgI to isofumigaclavine A (PubMed:28620689). Penicillium roqueforti has interestingly at least two sets of genes for the consumption of chanoclavine-I aldehyde on three different loci, the OYEs ifgG/fgaOx3 and the festuclavine synthase homologs ifgF1/ifgF2 (PubMed:28620689, PubMed:28902217). The reason for the duplication of these genes is unclear, probably to ensure the conversion of chanoclavine-I aldehyde by differential gene expression under various environmental conditions (PubMed:28902217).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>4-(3-methylbut-2-enyl)-L-tryptophan + S-adenosyl-L-methionine = 4-(3-methylbut-2-enyl)-L-abrine + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:34435"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:58209"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:67248"/>
            <dbReference type="EC" id="2.1.1.261"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Alkaloid biosynthesis; ergot alkaloid biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the methyltransferase superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.261" evidence="1"/>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QL00"/>
    <dbReference type="SMR" id="W6QL00"/>
    <dbReference type="STRING" id="1365484.W6QL00"/>
    <dbReference type="OMA" id="FGCSYKY"/>
    <dbReference type="OrthoDB" id="659at2759"/>
    <dbReference type="UniPathway" id="UPA00327"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035835">
        <property type="term" value="P:indole alkaloid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051128">
        <property type="entry name" value="EgtD_Methyltrsf_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019257">
        <property type="entry name" value="MeTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017804">
        <property type="entry name" value="MeTrfase_EgtD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017805">
        <property type="entry name" value="SAM_MeTrfase_EasF-type_put"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03439">
        <property type="entry name" value="methyl_EasF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43397">
        <property type="entry name" value="ERGOTHIONEINE BIOSYNTHESIS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43397:SF1">
        <property type="entry name" value="ERGOTHIONEINE BIOSYNTHESIS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10017">
        <property type="entry name" value="Methyltransf_33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018005">
        <property type="entry name" value="UCP018005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0017">Alkaloid metabolism</keyword>
    <keyword id="KW-0489">Methyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000444537" description="4-dimethylallyltryptophan N-methyltransferase ifgB">
        <location>
            <begin position="1"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="B6D5I7"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="28620689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="28902217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="4">
        <source>
            <dbReference type="PubMed" id="28620689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <evidence type="ECO:0000305" key="6">
        <source>
            <dbReference type="PubMed" id="28620689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM36676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="340" mass="37904" checksum="6C47190C75C1D5C0" modified="2014-04-16" version="1">MTIINSRIIDIRQSTFEESIPDQVTAGLSTTPKTLPALLFYSGEGIRHWIEHSTAADFYPRHEELRILRARAAEMVDSIANNSVVVDLGSASLDKVLPLLEALEASKKNITFYALDLSFSELQSTLQSLPYEQFKFVKIGALHGTFEDGVQWLKDTPGVQDRPHCLLLFGLTVGNYSRPNAAKFLQNIASNALAASPVQSSILLSLDSCKMPTKVLRAYTAEGVVPFALASLDYGNTLFAPNKMGEKVFQPSDWYFLSEWNYMLGRHEASLITKGKEVRLGGPLNDIVIEKHEKIRFGCSYKYDTDERQVLFGSAGLTDVKEWSVEGCDVSFYQLQMCPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W6QL43</accession>
    <name>W6QL43_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Major facilitator superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S03g001636</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QL43"/>
    <dbReference type="STRING" id="1365484.W6QL43"/>
    <dbReference type="OMA" id="CRVIFFA"/>
    <dbReference type="OrthoDB" id="10027823at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23520">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G04000)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23520:SF5">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G04000)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="66"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="101"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="192"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="267"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="305"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="339"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="3">
        <location>
            <begin position="5"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM34909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="463" mass="50119" checksum="09992B75B49941A9" modified="2014-04-16" version="1">MENQSRPARYMGHVLEELGLTTMWRSSLDVKLLCAQRFVRLFAYGGSTLILASYLSAMGISDDRIGLFMTLTLIGDVVISFFLTLYADAMGRKAVLSLGSILMAGSGVIFALFGNFWVLLAAAVLGVISPSGNEIGPFRAVEESTLAHLTPHELLSDVFAWYSLIGTAGSAMGMLVCGWIINSLESIHGWEFIPACRIIFFVYAGVGVVKLIFTLGLSEKVEVQKEEPQEQISETQPLLVEAVGRDIEPATRKKWLFPSIEKDLWSLVIRLFILFGVDSFASGLASLSWMTYFFRGKFNLPEGELGTIFFTTNIISAASMLIASSLAKRIGNVKTMVFTHLPSAICLALISVPSSLPLALTFLVLRACSQNMDVAPRSAFLAAALPAKNRTAIMGAVNVVKTTAQSMGPLLTGILSRNGHFGVSFIIAGCLKVIYDLGMLFSFAGKEAASRKQAATDTDEETS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>W6QL85</accession>
    <name>W6QL85_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="10">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PROQFM164_S02g000441</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QL85"/>
    <dbReference type="OMA" id="AQSANWF"/>
    <dbReference type="OrthoDB" id="5399138at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000134">
        <property type="entry name" value="MFS sugar transporter protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF2">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="39"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="75"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="135"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="165"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="253"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="290"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="320"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="352"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="418"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="3"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDM30292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="468" mass="50254" checksum="7838A68997AD02DF" modified="2014-04-16" version="1">MLACILCSANGILFGMDTGIIGPVTDMKDFKKSFGSQNSTIHGLIVSCILIPAALSSFFAGYVADRLGRPKGICIGVFIFGVGAAIEAGAVALSMFIVGRVVEGLGEGLFLGNIVVLICEISPTSTRGALTTGPQLAITLGLVMGYFISYGTSSLHSSLAWRTPFILLAAFSMVMCGLSLLYLPESPQWLGLHGRYAMAEEAWDKLGVSRAEREKVVLQVRTQEVETEIEKPKEGTVDKLLAIFSKDVLGRTILAVFLMGMQQLSGIDGVLYYAPQLFQKAGLASSEASFLASGVSALVIFAVTIPGLIYADKWGRRSSIIYGGVVMGILMFLMGGLYAGNAVHKSTGVGRWVVIVCIYLFSALYSVTWGISVKVYSAEIQPQRTRASATTLAHSSNWVCNFLVALTTPVLLAKSSFGVYFLFGGCCVITVIVGVLFMHETKGRTFGEIDEAFKGKSRWRKNKLGRDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>W6QLV8</accession>
    <name>W6QLV8_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Lysine--tRNA ligase</fullName>
            <ecNumber evidence="3 11">6.1.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 11">Lysyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">krs1</name>
        <name evidence="14" type="ORF">PROQFM164_S04g000075</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>tRNA(Lys) + L-lysine + ATP = L-lysyl-tRNA(Lys) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:20792"/>
            <dbReference type="Rhea" id="RHEA-COMP:9696"/>
            <dbReference type="Rhea" id="RHEA-COMP:9697"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78529"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.6" evidence="3 11"/>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QLV8"/>
    <dbReference type="STRING" id="1365484.W6QLV8"/>
    <dbReference type="OMA" id="DFRNEGM"/>
    <dbReference type="OrthoDB" id="21243at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004824">
        <property type="term" value="F:lysine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006430">
        <property type="term" value="P:lysyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00775">
        <property type="entry name" value="LysRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04322">
        <property type="entry name" value="LysRS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000050">
        <property type="entry name" value="Lysine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000044">
        <property type="entry name" value="Lysine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00252">
        <property type="entry name" value="Lys_tRNA_synth_class2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002313">
        <property type="entry name" value="Lys-tRNA-ligase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034762">
        <property type="entry name" value="Lys-tRNA-ligase_II_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044136">
        <property type="entry name" value="Lys-tRNA-ligase_II_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018149">
        <property type="entry name" value="Lys-tRNA-synth_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00499">
        <property type="entry name" value="lysS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001756">
        <property type="entry name" value="PRK00484.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42918:SF9">
        <property type="entry name" value="LYSINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42918">
        <property type="entry name" value="LYSYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039101">
        <property type="entry name" value="LysRS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00982">
        <property type="entry name" value="TRNASYNTHLYS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="13">
        <location>
            <begin position="252"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="19"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="584"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="23"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDM35194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="605" mass="69369" checksum="A4A2BEE56FF01C31" modified="2014-04-16" version="1">MADSNPVQEATASIANLLLDDVTGEKVSKTELKRRQKQREKDAKKKEKEAAAPPKPKAEKKSSAEDDEANLTPNQYFEIRSKRINKLRETKQPDPYPHKFHVDTDLRKFVKDYEGLQKGEQKPDVTVRVAGRIYTKRTSGNKLNFYDIRSEGVKIQVMCQAQFSTGKPFEEQHELLRRGDIVGIVGFPGRTNPKNRDDGELSIFATEVILLAPCLHAIPSEHYGFQDKEQRFRQRYLDLIMNDRSRDILRKRSKIVSYIRQYFENLDFIEVETPMMNAIAGGATAKPFVTHHNDLDMDLFMRVAPELYLKMLVVGGLERVFELSRVFRNEGIDLTHNPEFTTCEFYQAYADVYDLMDLTEDLVSNLVKHVTGGYETVFHTQSGETYNVNWKAPWRRVEMMPALEEACGEKFPPSDQLHTQETNEFLKRVLKKMNVDCSAPQTNARMLDKLVGEFIENTCINPTFITGHPQMMSPLAKKHRQMAGLCERFEAFVCTKEIINAYTELNDPFDQRMRFEEQANQKDQGDDEAQMIDETFCQSLEYGLPPTAGWGLGIDRIVMFLTDNYSIKEVLTFPMMKDDKTAADPKTAAEVVGIEPSPEEGIPHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W6QLY1</accession>
    <name>W6QLY1_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Small subunit of serine palmitoyltransferase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PROQFM164_S06g000422</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792020">
        <property type="protein sequence ID" value="CDM37460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QLY1"/>
    <dbReference type="STRING" id="1365484.W6QLY1"/>
    <dbReference type="OMA" id="AMGTYIY"/>
    <dbReference type="OrthoDB" id="202672at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024512">
        <property type="entry name" value="Ser_palmitoyltrfase_ssu-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11779">
        <property type="entry name" value="SPT_ssu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM37460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="122" mass="13957" checksum="F29C5092B8007503" modified="2014-04-16" version="1">MVDFIIWAVASLFRWMRLKIYQYEVTFSLYMLTPIEKLIFNTLLLGLIAMIAMGTYIYLPDHLLAIYGRLYYYWAGERLFSSGRLSISSVFGENGVATQIGDLMYETAKNAAATSTERLADL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W6QM26</accession>
    <name>W6QM26_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S02g000772</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QM26"/>
    <dbReference type="OrthoDB" id="5350472at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM30622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="157" mass="17764" checksum="23CD752897F3DCCF" modified="2014-04-16" version="1">MVLPKLAIAHDSSVPTKTQKAKDRLLYTDLLQANNSRCGDGHTRKPRRVSTTRILTQKIGNCAETYPWVHFLGSWSIGNRNVHGIYLQCKDLRPAQYEDSLRGETWKRVSDPCFNCQEIISIHGGVVSNFSRYSGSAGAPPKCYALRFAMYSCLIWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W6QMP7</accession>
    <name>W6QMP7_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type DNA-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PROQFM164_S04g000325</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QMP7"/>
    <dbReference type="STRING" id="1365484.W6QMP7"/>
    <dbReference type="OMA" id="EHMLNFG"/>
    <dbReference type="OrthoDB" id="4314040at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF7">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="13"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM35444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="490" mass="55509" checksum="626A896D6F9EAECF" modified="2014-04-16" version="1">MAGSEKFSRSRTGCLPCRKKHNKCDEQQPVCAFCASRDLDCKYPLGVKWVRPKEPMPTRHKPRCKDTRRAEQNMLGRPSTLFTETCFESAEDKSAWEYYVSLVSSNVPAVDGPDNPYRQVSIPALSSPILLETIVCISTEHMLNFGLTSIDLAAKRQQRMLRTLGKNLLSIEARAACDSGTIVASNKHEREALLTAVVLQGIVVAQTADGVLEPHVKCASWLMQALGYFDEIPQNPIARMTVQRFGMVDVMLAISRQRRPYAPQRFILYQPDQSRWDTTEPSFHKMTGCPQPLMCFLVRIAHLACDVSDGLETQPDKGVLNEAFQLDTELRAWGSGYCGIPPARCERTPLDILTECFYWTAHLLLARRVFRDQTCSPRVQHLAHLCFGLMDHLSTGCGPDSSLPQPFYIAAREAVSPEDRMWVRQKHESMTAYYREQQRNSAMELIEQIWETTDRLRELGNDSGWPRGTELSIVDSYVQALDRGACFFIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W6QND5</accession>
    <name>W6QND5_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">DNA-directed RNA polymerase III subunit RPC3</fullName>
            <shortName evidence="9">RNA polymerase III subunit C3</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">rpc82</name>
        <name evidence="14" type="ORF">PROQFM164_S04g000520</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 9">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 9">Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the RNA polymerase beta chain family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QND5"/>
    <dbReference type="STRING" id="1365484.W6QND5"/>
    <dbReference type="OMA" id="KHRFVRH"/>
    <dbReference type="OrthoDB" id="272392at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055207">
        <property type="entry name" value="POLR3C_WHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013197">
        <property type="entry name" value="RNA_pol_III_RPC82-rel_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008806">
        <property type="entry name" value="RNA_pol_III_Rpc82_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039748">
        <property type="entry name" value="RPC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12949:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12949">
        <property type="entry name" value="RNA POLYMERASE III DNA DIRECTED -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08221">
        <property type="entry name" value="HTH_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05645">
        <property type="entry name" value="RNA_pol_Rpc82"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22536">
        <property type="entry name" value="WHD_POLR3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9 14" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RNA polymerase III subunit RPC82-related helix-turn-helix" evidence="12">
        <location>
            <begin position="9"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase III Rpc82 C -terminal" evidence="11">
        <location>
            <begin position="186"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed RNA polymerase III subunit RPC3 winged-helix" evidence="13">
        <location>
            <begin position="488"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="138"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="222"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="409"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="140"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="151"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="235"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="273"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="291"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF22536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDM35639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="650" mass="74138" checksum="1751E80127FB7F2E" modified="2014-04-16" version="1">MMMSQCSTELCMLLIEDNFGELFARIFTVLQRYERLTLPRLRFYARLTDRQLHHGLSAMIQHHLIYHFTSLDDGNTYYEANPQAAYSLVRSGKILQLVETRLGEYAAQVLEAIMSLGHSSIAHLETLPELQSKRQRIPNGVNQGENTVENTVEDTVDGNGEKEEDSAAPNGNHVVREKPVHLHPTLKSLASHGYIHRLREAHFQSPNDNWIDASRIIASRPDVKQMKGKQQATEIEEKAKDLVKERTEGDLSRGLIYNGLPQGAKRKRDHGNSESNKQAPNGTNGVNGDHVEDEGEEDNDWSEDEDGVDSIPMDSNLIVRVNYEKLDVALRNTRFLDLAKQDAPSASVEIYDCLLRRIEYQTARCRDSYEIPREGEEGEQYSAPIQLSSIVEDVDPNLDLTGCIGPMEPSTVLNRGGKRPLDDETNGVNGDEHEDEPSGQNRAYGIDQHLSILSQPPLNLTTKHVISGLPTWRVAFRGLARKLRHLELERMIESRYGDVALRVVRVLHAKGKLDEKRLQEISLLPFKDLRQTLASMQTGGFVDLQEVPRDAQRQPSKTIYLWYYDPDRVCSSMLEDTYKAMSRCLQRIKFERGRERDFLEKTERTDVKGHEEEFLSEAELEHLRNWKAKEALLLAEVSRLDDMVAVFRDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W6QND8</accession>
    <name>W6QND8_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Altered inheritance of mitochondria protein 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S02g001312</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AIM6 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QND8"/>
    <dbReference type="STRING" id="1365484.W6QND8"/>
    <dbReference type="OMA" id="VRYWGLP"/>
    <dbReference type="OrthoDB" id="4153866at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051236">
        <property type="entry name" value="HAT_RTT109-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31571">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31571:SF1">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="89"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM31162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="454" mass="51334" checksum="5ECED6E71FE5425D" modified="2014-04-16" version="1">MMSPFRPPQTNSVSSLHFDPYRDSLDTEYPKVNVHVDSVDSERVGYPARSWRQVWTALAWPSTSSMLSENPAKRKRSCRSRYLHGLRRAIIGIFIMLGIIQFISIACGIALSFFPDEYDRAVHNWLPSTDGTNTIDSTRWPTDISRDIVPVGCHSHNDYWRRVPLYSALQAGCIGVEADVWLFDDELYVGHTTSSLTERLTLQSMYIDPLVSILERQNPTTRFHRGGHSHTHGVFGTDPAQSLILLIDFKTAGAATWHAVMKQLAPLRDRGYLTHFNGDELIQGPITVVGTGNTPFNLVTENTTYRDIFFDAPLDKLVGTDQPDSSIPDAALFPRTDLGTDLGQGQSGMPAVITASTFNTSNSFYASVSFKKAIGYPWPFHFTQRQMDLIRSQVRIAHQHGLKVRYWALPSWPRSLRNHIWRVLAQEGVDILNVDDLVDATKGVWNTRVFDWWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W6QNJ0</accession>
    <name>W6QNJ0_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PROQFM164_S08g000006</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792022">
        <property type="protein sequence ID" value="CDM37955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QNJ0"/>
    <dbReference type="STRING" id="1365484.W6QNJ0"/>
    <dbReference type="OMA" id="WGSTIFA"/>
    <dbReference type="OrthoDB" id="9986881at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF59">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G10370)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="111"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="141"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="199"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="234"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="301"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="341"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="385"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="410"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="449"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="477"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="74"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM37955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="515" mass="56857" checksum="F464F503CB77FE5E" modified="2014-04-16" version="1">MAALKKELVTPDNWSDRDGTTRSILSKLRIRHPDHEVAHTHRLGHLKTDSEHLVQFDGSNDPYKPLNWSFTKKSVTTVLYGFITMGSAWASSAFSPAISDVDKQYRISKEVGTLGVSLFLFGVGLGPLLWAPCSEVYGRKVAVLAPYAIAVALSFATAVSKDIQSIMITRFFTGFFGSAPITNVGGVLADIWSSQSRAIAVTVYALTLVSGTVIAPIVGGAIEVTNLDWRWTEYITGIIMALSLILGAIFLDESYPPVLLVYKSRQLRLRSGNWALHAQHEEWDVTLSELSSKHLARPFQLLMTPICFAIALYASFVYGVLYLSLASFPIEFQELRGWNPLVGALPFLGLLFGFFLGAAVNITNQRFYSQRFQANNNRPVPEARLPPMMIGSVFFAAGLFILGWTSEPHIFWFGPICGAVSTGLGFFTIFQAALNYLIDTFSEYSASAVAVNTFLRSIFAGCFPIFANAMFHKLGTAWAFSLLGFVAVALIPIPFVFYIYGPQIRARDRWSKISV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W6QPI8</accession>
    <name>W6QPI8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein kinase-like domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S11g000013</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792025">
        <property type="protein sequence ID" value="CDM38310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QPI8"/>
    <dbReference type="STRING" id="1365484.W6QPI8"/>
    <dbReference type="OMA" id="GENEYRM"/>
    <dbReference type="OrthoDB" id="5979581at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM38310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="227" mass="25793" checksum="D014E1FEC444E940" modified="2014-04-16" version="1">MSLGDWGENEYRMQNEILQNVHDTSHLVMYLGTFLIPGSGHRVLVFPLMGPCIVPIEIEKMPMASRMFAARQLLEALESLHKEELCTVGSRPTILIFRSNEKFIDLNERNFKVPENLRTEEFFLGDFGLAKKLTDSVTQRGYPPSKYCSPERLHGEAPSLNSSGFVRSLGLLPEKWKGLYPGGLDYWYDQSQTPDPDLDVASRIAYFRPDADPIERNHVASIMSKVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W6QQ17</accession>
    <name>W6QQ17_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S09g000002</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792023">
        <property type="protein sequence ID" value="CDM38086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QQ17"/>
    <dbReference type="STRING" id="1365484.W6QQ17"/>
    <dbReference type="OrthoDB" id="3945418at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM38086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="124" mass="14414" checksum="78D566FB0369EAE7" modified="2014-04-16" version="1">MSATRDVFGKLWLSSKAVYNIWFHPLRNFPGPWYTKVSRIWYVLRVLQGCHKYEIKRLHDEYGLVVRIVPDELSYIDPRAWNGIYGSVVYNHGLYPMEKDGDFFATAFGDSETLVGAKSAEYKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W6QQ52</accession>
    <name>W6QQ52_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PROQFM164_S29g000002</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="HG792043">
        <property type="protein sequence ID" value="CDM38596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QQ52"/>
    <dbReference type="STRING" id="1365484.W6QQ52"/>
    <dbReference type="OMA" id="IPCSEME"/>
    <dbReference type="OrthoDB" id="5979581at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050684">
        <property type="term" value="P:regulation of mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05118">
        <property type="entry name" value="STKc_CMGC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051334">
        <property type="entry name" value="SRPK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634:SF9">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="98"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDM38596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="487" mass="54728" checksum="E399B5F9C05C95D0" modified="2014-04-16" version="1">MYPEGLAARSLRTSIQFLPKFRTSPLQFCISHETFRSATLGQRSAAMSTSSPPTPPSRALIDGELRFKTITLPCEWVEDYRPGGYHPVVLGDVFNRQYKVIRKLGEGSYSTVWLARDLDGYVALKILVSEISGSTTELRILRHIIEVAPVEGTRYITRLLGEFEHRGPNGVHKCLVFEPMGPSVNTMVEELPQFKPRRREMKIRYPLQMAKSILKQSLQALVFLHENGIAHGDFQPGNILFTLNDIDSTPEDLLRQEEDVQSRSISPPVQRLDGKQDGWAPRYLCVAQPLVPFTCYAEGFKVKLSDMGGAYFFTDPPAKPVTPLGLRAPEFILTGAVDNTVDIWSFGCLVFELITGQPLFCIPSSEMEDDDHLLSLTAQLGALPDELYKHWTTSSLYFTPERKLFNCQLGGVAPGEEPLMVEQTSMEESFDRTGLDLDEEEAHKVKALIRWILQYDPAKRPSPAKILADPWFCEIDVESDSSRASIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W6QRG5</accession>
    <name>W6QRG5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S05g000482</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QRG5"/>
    <dbReference type="OMA" id="FFMSEVC"/>
    <dbReference type="OrthoDB" id="4289218at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="266"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM36649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="309" mass="35140" checksum="532511921014F177" modified="2014-04-16" version="1">MPLQGLGLISPFLQQSSYQSKVGISNLSQMLSPTLKYGSRQALGRLLQQWIESPESDSSGGICPILPSKLKFKDLKKCKKLEIDIQMHPYLPIQIEYEFEQHGIMGPTGGAWDMVSIEEPDAPRDPEYPHVHTWKGQIAPGVLMIEEIKKIPGFFMSEVCQAIYQNYFPIDSLKYIYMIDVCNKDTRSFAINELYTEANGYTWEKDTINCIPGTPEFEALLGTKLGRTVAHLVLGAFKRGTRRISQIKVFDNFEALQLEFSIVPTDAPAQSSSTRSTRSKTRREQSIESRKRKRDSSEEPAKKRLKREK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2024-10-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>W6QRS9</accession>
    <name>W6QRS9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S02g002388</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QRS9"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM32237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="39" mass="4193" checksum="3EB9C15220C690CA" modified="2014-04-16" version="1">MPNSLGHISEPVNVGRFAVPESCLCYETVKVPFIISSGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W6QTZ2</accession>
    <name>W6QTZ2_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Amidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PROQFM164_S06g000576</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the amidase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792020">
        <property type="protein sequence ID" value="CDM37614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QTZ2"/>
    <dbReference type="STRING" id="1365484.W6QTZ2"/>
    <dbReference type="OMA" id="MDQYYTA"/>
    <dbReference type="OrthoDB" id="6428749at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072:SF2">
        <property type="entry name" value="AMIDASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072">
        <property type="entry name" value="AMIDASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001221">
        <property type="entry name" value="Amidase_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="5">
        <location>
            <begin position="76"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="3">
        <location>
            <position position="131"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="3">
        <location>
            <position position="206"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="3">
        <location>
            <position position="230"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="227"/>
            <end position="230"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDM37614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="548" mass="60805" checksum="800499839BB63F3F" modified="2014-04-16" version="1">MGSSQSWEEIVAHKRLIRDQLIAPYLVDVAQRLPQVQNPEERTRLEDPLIQKITDIDNVAALLECLGKGEFQAEQVIKAYIQRVVVAHQLTNSLTEILFEDALGQAKQLDVEFAETGKLKGPLHGIPITLKDQFNVKGVDTTLGYVGRCFAPAQEDAVLVQILKNMGAIVIAKTNLPQSIMWAETDNPLWGLTTNPRNPIFTPGGSSGGEAALLTLHGSLFGFGTDIGGSIRMPQAIVGLYGFKPSSARLPYEGVPVSTEGQEHVPSSIGPMARNLSSICYMSRLLANSQPWDLDSRCAPLPWNETAFQEPQDRPLVIGLILDDGIVKVHPPILRALQELSTVLKANGHEVVVWDTSDHAGCIEIMDLFYTVDGGEDIRQDVAVAGEPFIPHVEALVNRGKAISVYDYWQLNKRKAAVQKKYLDKWNAVRSPSGRAVDVLLSPTLSHTTVPHRKFRWVGYTKIWNLLDYPALTFPVDRVRADLDVLPSEPYVPRNSVDEWNWNLFDLKQADGYPVNLQIIGKKLQEEKVLGAATVIEKLWKSHVDKSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W6QUY6</accession>
    <name>W6QUY6_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Probable transposable element</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S03g000086</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QUY6"/>
    <dbReference type="STRING" id="1365484.W6QUY6"/>
    <dbReference type="OMA" id="KQHAGIN"/>
    <dbReference type="OrthoDB" id="10264707at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052742">
        <property type="entry name" value="Mito_N-acetyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015416">
        <property type="entry name" value="Znf_H2C2_histone_UAS-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43138">
        <property type="entry name" value="ACETYLTRANSFERASE, GNAT FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43138:SF2">
        <property type="entry name" value="PROTEIN SPT10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09337">
        <property type="entry name" value="zf-H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="65"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="339"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM33362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="518" mass="58072" checksum="0CF9F18CCC142B6C" modified="2014-04-16" version="1">MSEVHGDSELVPSGPDLDYPLALAPRQVTLRDRVTVATLIPFTSAEEVPRALMKYLSDQFNKEIEKGDTYAMTEPIPLAQFGRYWFSNFGVVMLIGDIESAEQTHAMDRAGANWTKICLGGFHIRPNYPGRSSHVCNGTFIVTDAARNKGVGRLMGESYLEWSPRLGYTYAVFNLVYESNVASCRLWDSLGFKRIGRVPGGGSIKSQPGEYVDAIIYGRGLSLDGEDSVSQDRFEKIRYYLKHGKYPRGADRAEKSRLRSAATHYKLLGGEDGEPEKLMLKDKEVVSDPQQQYDIAQEVHLKHHAGINKTTAAIAIKYHWVRIKETVNRVIRDCPQCKETLKVPPIPGTKDDDKSPSETMSGMDMDSTMEQPPKDPINVPQEMDEAPDEPPNYNPLMHQPIPAAMPDTVHSMAGFAPMPLDPQIMQLHQQLRRYQQHNSMTGQFAPNPHNLSMSSFDDAMRYHTASNAYQMMVDDGSDPFRQDVLGLVNPPSHELQHDAELLAKFEYGSPSDGNYDFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W6QVJ6</accession>
    <name>W6QVJ6_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S03</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S03g000311</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QVJ6"/>
    <dbReference type="STRING" id="1365484.W6QVJ6"/>
    <dbReference type="OMA" id="IAFRFHK"/>
    <dbReference type="OrthoDB" id="5376498at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM33587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="159" mass="17982" checksum="7D503F4E654305A7" modified="2014-04-16" version="1">MPPRQSKTDSRAVTVLFKKHKTTVLLMLQPHESLYFVKKRLLDALKSRNITNINGDIVPDSTSDVEFGEPVDRADLEKGWKRLQADVPGMDNEGAPKRNMNQNDSPTVMEADLENGYSIAFRFHKSTEDQSGGLDMDLDGEDPGWDVIMPTYEDEPEEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W6QW21</accession>
    <name>W6QW21_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S11g000007</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792025">
        <property type="protein sequence ID" value="CDM38304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QW21"/>
    <dbReference type="OMA" id="PDIMIAS"/>
    <dbReference type="OrthoDB" id="4499271at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM38304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="183" mass="21056" checksum="30F998490331D57A" modified="2014-04-16" version="1">MEFLRLWMSEAAFVIPDDLTQVAFSSLESAGFLPCNSLGCPHLDTNRVPPEFKHLHINDEVAVSLYRKSDVLWEFDLEKNPDIMIASDDRLPSASPGRGRGRFLSCPCTVKIHSAVRYCEALILLLCRDYDSSYETYWLAILSYMLEYVDGTDILDENKLQEGYRKFYHALKTRRSRDVFNTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W6QW67</accession>
    <name>W6QW67_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein family UPF0646</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S11g000087</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792025">
        <property type="protein sequence ID" value="CDM38384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QW67"/>
    <dbReference type="STRING" id="1365484.W6QW67"/>
    <dbReference type="OMA" id="RLCHNDG"/>
    <dbReference type="OrthoDB" id="5339076at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018822">
        <property type="entry name" value="UPF0646"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10336">
        <property type="entry name" value="DUF2420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="457"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="495"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="526"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="608"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="653"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="674"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="694"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="725"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="738"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="757"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="786"/>
            <end position="797"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM38384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="825" mass="90943" checksum="7057AA8317F7907A" modified="2014-04-16" version="1">MEAPATGDSMEMASPYQGPADDFDIDIDLMEDHVSNMDSDMMGAEEFTNTSQPTELNNDAIYDADMADEPSEGSMIDADNYADEDNDIDVQFEEEPYEEEMIEADQVEDVNIATPIIHLEPAGRNEDAASPIKEDITVTSVELLEAAPQELSDSAGLAPVSDKAQVSEVEGQDTQTHLSTAVDDLTEEPSGNAISTETRGHNEKAELGEEANETSKSPLTEAEVTQVPNEDPETSQIKPSAEYSHDDAAHPEAQPVSEENHQVADEEHSPQQVTYMDEPLHPVKILYQDCEIALFPPLEGDSSDTFFIEDEALAYDNVDQIFKALRQVLQKTMAGNEVLVIDIDTLGIQITEDSIHTSQVTLHQILDLYLRLCRNDGTTDPEALYLTLSTKRAFPAEIADLNDAAMEGKKLSELHSELQSWDEYDEGEPGSEGDLVAHGAEEHEDELYYTNEAQKELSTTEVQTAPAPGEDQALDGEHPQVQPEAVSGAQSEIVHAQDEDRSTSRERSAEAAREPESHPAQPENTEPDHLDVSRHLETDQDQEYDHGDGDVNEENYDSEGRQSDSTATLAALPGASEIQEHTEHAPLDVSVNAVTDENDNDHYYGENAENDDLGDDEYYEDDPVEDLEAFQNDITGSENADDAQEPADQAPVFDEEDTDELDAPPTDEVVSETTLRDESKHFSHDQPAPPLDSGLHDTSDKKEKTPEPADDLLGIAVDLMQTPPRDTENDALDHFEGIDYDEPEDELDAPVAADDGGANHEFDENHFGDYDTHFEESEAVELVGTDPSSTDAETHPNSSSKRSREDEDDWDLVESTIDTKRRRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W6QXS4</accession>
    <name>W6QXS4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PROQFM164_S03g001056</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QXS4"/>
    <dbReference type="OMA" id="HRKFYAE"/>
    <dbReference type="OrthoDB" id="194139at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06174">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507:SF31">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G14230)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507">
        <property type="entry name" value="ZGC:174356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="222"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="250"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="357"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="395"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="440"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="494"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="526"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM34332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="570" mass="63237" checksum="35410DB17D70830E" modified="2014-04-16" version="1">MASIRHESLDREDREDAPFLDSPDLSTPGSAHRHVSSKPSIGSHPFKANASASTITFRLKVTLFAMVLAVEIGFAFLEGPMVRIMESIACRQYFLGVDPTKIGADGQVPEAMCKIGEVQAELAAVKGYHMFFDGSLSALLAIPYGLLADRRGRKSTLALSLPGFGLNALFTILILWFSDIFPLRALWFTALTWLFGGGPVVSFAIIWTMMADVTNESERAELFFQFAIVSMGADFASSAVSSYLMTLNPWIPLVVGFAIVMAGMMLILALPETKHALPPRKAEPTHVEMSDLTHDTEPKNSIHIPRVPEPYRAEPDMNGDHDDEPPSWSIQSYSHRSILAKFRANYRFYLRPYRFILNRKPVLLLLTAFLVYRLSRGSSWFLTQYISTRYSWTLAQANFLVSARPTVSIPLFLFVLPFLKRRVVNPRLSSTEKDLWLARRSIFCLTVGTLGIGLSPTIATLIPSMIVQTSGSGFVFLARSIITTLVERDETARLFTAIEIIQSLGNVVASLSITTVFQIGLRLGGVWIGLAWMMTSTLFCLVGVAIWSFNLPPSPPTPDFAEDYDGDDRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W6R0K0</accession>
    <name>W6R0K0_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cofilin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Actin-depolymerizing factor 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">COF1</name>
        <name evidence="7" type="ORF">PROQFM164_S04g000228</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the actin-binding proteins ADF family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6R0K0"/>
    <dbReference type="STRING" id="1365484.W6R0K0"/>
    <dbReference type="OMA" id="YAIYDME"/>
    <dbReference type="OrthoDB" id="10249245at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016363">
        <property type="term" value="C:nuclear matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030042">
        <property type="term" value="P:actin filament depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11286">
        <property type="entry name" value="ADF_cofilin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002108">
        <property type="entry name" value="ADF-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017904">
        <property type="entry name" value="ADF/Cofilin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11913">
        <property type="entry name" value="COFILIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00241">
        <property type="entry name" value="Cofilin_ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00102">
        <property type="entry name" value="ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51263">
        <property type="entry name" value="ADF_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADF-H" evidence="6">
        <location>
            <begin position="6"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM35347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="150" mass="16779" checksum="1B44D423B0100C0C" modified="2014-04-16" version="1">MSNPSGISIADECMSAFNQLRSGPEATRPKFIIYKISDNNKSVMVEETSTVKDYEFFRRKLSAAVDKDGNPAPRYAIYDMEYDLGSEGKRTKAVFVHWGPCHASIKLSMLYASSVQQFKRAFGLNVSFFADSLEELEWAVVLKEVSGGQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W6R0L0</accession>
    <name>W6R0L0_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Phenylalanine--tRNA ligase, mitochondrial</fullName>
            <ecNumber evidence="3">6.1.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Phenylalanyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">MSF1</name>
        <name evidence="18" type="ORF">PROQFM164_S04g000243</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Is responsible for the charging of tRNA(Phe) with phenylalanine in mitochondrial translation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>tRNA(Phe) + L-phenylalanine + ATP = L-phenylalanyl-tRNA(Phe) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19413"/>
            <dbReference type="Rhea" id="RHEA-COMP:9668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78531"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.20"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="3"/>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6R0L0"/>
    <dbReference type="STRING" id="1365484.W6R0L0"/>
    <dbReference type="OMA" id="PISHYPQ"/>
    <dbReference type="OrthoDB" id="4457at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00496">
        <property type="entry name" value="PheRS_alpha_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.380:FF:000002">
        <property type="entry name" value="phenylalanine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000053">
        <property type="entry name" value="Phenylalanyl-tRNA synthetase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.380">
        <property type="entry name" value="Ferrodoxin-fold anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005121">
        <property type="entry name" value="Fdx_antiC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036690">
        <property type="entry name" value="Fdx_antiC-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004530">
        <property type="entry name" value="Phe-tRNA-synth_IIc_mito"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002319">
        <property type="entry name" value="Phenylalanyl-tRNA_Synthase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00469">
        <property type="entry name" value="pheS_mito"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538:SF41">
        <property type="entry name" value="PHENYLALANINE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538">
        <property type="entry name" value="PHENYLALANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03147">
        <property type="entry name" value="FDX-ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01409">
        <property type="entry name" value="tRNA-synt_2d"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00896">
        <property type="entry name" value="FDX-ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54991">
        <property type="entry name" value="Anticodon-binding domain of PheRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51447">
        <property type="entry name" value="FDX_ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 18" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="16">
        <location>
            <begin position="121"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="FDX-ACB" evidence="17">
        <location>
            <begin position="422"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="56"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="57"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00057761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00073229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CDM35362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="527" mass="59584" checksum="2AB45271796FE399" modified="2014-04-16" version="1">MDNLGILTTSSSTMRLFATGRALRASSGRWSIASIRPQTAIPRSLPLTPILSRNREWSSTAARRSEQKATTTSKIPQQQSSLKIEGETYPTDQWTNTPDTILSHIGRRLYLDENHPLAITRKLIESQFAAPNYGNYSEKNPVVSTRQNFDVLGFPADHPGRSRTDTYYVNDKTVLRTHTSAHQQAYFQQIARNEHTRPEEVGYTVIADVYRRDAIDRSHYPVFHQMEGAMLWKRPATNPLAASAETAARIMADVEKIPRHDVVVEDPNPTIHAQRNPLQDEHHSAEEVEAVAAHLKRSLERMVIKVFTEASKAAAASSGGAEQEPLKVRWVEAYFPFTSPSWELEVFWQGDWLEILGCGIIKQDLLINSDVPDRIGWAFGLGIERIAMLLFNIPDIRLFWSRDERFLSQFRAGHIARFEPFSKHPACYKDVAFWLPPAAVTGGNSAAGGAVPFHENDVMEIVRGIGGDLVEDVTLIDEFTHPKTSRKSMCYRINYRSLERTLTNEESNEMHLKVREKLVGELGVELR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W6R162</accession>
    <name>W6R162_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Heat shock 70 kDa protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">hsp70</name>
        <name evidence="8" type="ORF">PROQFM164_S04g000453</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6R162"/>
    <dbReference type="STRING" id="1365484.W6R162"/>
    <dbReference type="OMA" id="AYTKNQD"/>
    <dbReference type="OrthoDB" id="2401965at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10233">
        <property type="entry name" value="ASKHA_NBD_HSP70_HSPA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000172">
        <property type="entry name" value="Heat shock 70 kDa protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000058">
        <property type="entry name" value="Heat shock 70 kDa protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000001">
        <property type="entry name" value="heat shock 70 kDa protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000028">
        <property type="entry name" value="heat shock 70 kDa protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.10:FF:000016">
        <property type="entry name" value="Heat shock protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000026">
        <property type="entry name" value="Heat shock protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001413">
        <property type="entry name" value="PRK00290.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="578"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="583"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="605"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="626"/>
            <end position="635"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM35572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="635" mass="69734" checksum="C99FB93D5F945460" modified="2014-04-16" version="1">MAPAVGIDLGTTYSCVGVFRDDRIEIIANDQGNRTTPSFVGFTDTERLIGDAAKNQVAMNPHNTVFDAKRLIGRRFQDAEVQADMKHWPFKVIEKATKPVIEVEFKGEVKQFTPEEISAMILVKMRETAEAYLGGTVNNAVITVPAYFNDSQRQATKDAGLIAGLNVLRIINEPTAAAIAYGLDKKVEGERNVLIFDLGGGTFDVSLLTIEEGIFEVKATAGDTHLGGEDFDNRLVNHFVNEFKRKHKKDLTTNARALRRLRTACERAKRTLSSAAQTSIEIDSLFEGVDFYTSITRARFEELCQDLFRGTMEPVERVLRDAKIDKSSVHEIVLVGGSTRIPKIQKLVSDFFNKDANKSINPDEAVAYGAAVQAAILSGDQSSKSTNEILLLDVAPLSLGIETAGGVMTPLIKRNTTIPTKKSETFSTYSDNQPGVLIQVFEGERARTKDNNLLGKFELTGIPPAPRGVPQVEVTFDVDANGIMNVSALEKGTGKSNKITITNDKGRLSKEEIERMLSEAEKYKEEDELESARIQAKNGLESYAYSLKNTLSEGKLQINDDDKKKVEDKINEVIGWLDSNQTAEKEEYESQQKELESVANPIISAAYGGQAPPGAGAPEGARSADEVEEKPEELD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W6R5D4</accession>
    <name>W6R5D4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S05g000865</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM37032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6R5D4"/>
    <dbReference type="OMA" id="MTCHEMM"/>
    <dbReference type="OrthoDB" id="4199007at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM37032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="380" mass="42178" checksum="823F8C149B055A39" modified="2014-04-16" version="1">MDNPITEQMSNSALHRGSWESVSSAFSHLEMSFSHDSCYGSDEVSVTSNSCTPTQSGVSTATTKPTLRPFLKSILKNSTVAFDSDEESGSESGYSSDGIDSEYDALSDESDEEDDDGDSDFSVWDETNGDVPETHEDHTESFDDAFISFEENSVRFDPQVEYIDSVEVSDDEGPDHQMTCHEMMMLARDSKGTQTLLDQLDKMDIAESRKEHCHQEFGRKSTNQPEEFSRDAVDLDCSLFVAYMNGIRGIVTPKYKTYLRVQVDHIRLGKDTEFVDTEGAPSLYLDLVSNHVTGTFCNLLAEDELNELIRLRAVEQAGKQNDTSSSTLGLDHHQVLLNKIEKFLLDRLASGRVEIGPDELSFFAGGIAHELGTKTLPAQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W6R8P0</accession>
    <name>W6R8P0_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S10g000046</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
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            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792024">
        <property type="protein sequence ID" value="CDM38232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6R8P0"/>
    <dbReference type="STRING" id="1365484.W6R8P0"/>
    <dbReference type="OrthoDB" id="2014201at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM38232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="100" mass="11489" checksum="5D9F3392319D1912" modified="2014-04-16" version="1">MQAIANASSGDFDMEIVNDLYKDSAFVLPHRCYDLLTGEFRGKEHAGYLGNPLEEWDPYAILNETKFLHFSDWPVPKPWIEAPKDIIDEKQPTCDFNPLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W6R9E9</accession>
    <name>W6R9E9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S13g000010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792027">
        <property type="protein sequence ID" value="CDM38487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6R9E9"/>
    <dbReference type="OrthoDB" id="4347790at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM38487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="66" mass="7533" checksum="48AC75DDB4EB3445" modified="2014-04-16" version="1">MELGDCLFPQDLAHLESQVNHWQTERLWSFVGFGVLPGSSARHRIAGICQHIKEKGNLNAENYIRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W6PPU0</accession>
    <name>W6PPU0_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g000007</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PPU0"/>
    <dbReference type="OrthoDB" id="4273125at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM26198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="121" mass="14019" checksum="4B608565893E25F0" modified="2014-04-16" version="1">MAHVARKRTRQSAGDVSEATPLLERSARKTEGGFNQHPEGTTSTRRFRTQPSLEKKTTLRLRLRQEYFDPGSEEAWWTSLSTPNPNGEGRGHKQLEENADREQARLGWMQRLRPKPHRRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W6PPZ8</accession>
    <name>W6PPZ8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Collagen triple helix repeat</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S01g000047</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PPZ8"/>
    <dbReference type="STRING" id="1365484.W6PPZ8"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0176">Collagen</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM26238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="134" mass="14125" checksum="5C98770C36B95C62" modified="2014-04-16" version="1">MSVFRRRSLLNRTPPPLPERPDQQSHTASIGALVGVAIAVANALGWCLYCRQRLRGPRKGEGLPGSDGPRGIPGPPGPKGSPGDQEPIGSTGNIGQDGTPGLRGFPGIQGGAVCNNQWRPDLRILFLITSLPLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W6PR81</accession>
    <name>W6PR81_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Zinc finger C2H2-type/integrase DNA-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PROQFM164_S01g000184</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PR81"/>
    <dbReference type="STRING" id="1365484.W6PR81"/>
    <dbReference type="OMA" id="MLTGEGY"/>
    <dbReference type="OrthoDB" id="4748970at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000125">
        <property type="entry name" value="Putative zinc finger protein 143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051061">
        <property type="entry name" value="Zinc_finger_trans_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179:SF13">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="77"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="107"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="138"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="168"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="200"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="313"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="385"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="512"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="389"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="512"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDM26375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="549" mass="61820" checksum="979DED99CCD2B356" modified="2014-04-16" version="1">MAMKRKASSEGITTLKRHQKDNVLDNSDLIYQETHSDAEYSAPSTPSLMSEDMDESPATPFSATSSRQVYPSELKTLSCPFEGCDKAFNRPARLQEHIRSHNNERIFKCEVEDCDKTFLRPSHLQQHVKSAHTDIRDYVCDYRGCGKSFVNGSRLRRHVATHDGHNKYRCTEYPPCDETFRKHSTLQKHVMVAHLNQKPFPCDHVDPTTKEKCNMAFDKAGNLRTHQRRVHSEKRFTCAECAENMEAQSSNMADDDTKQDVSFPTYASLQNHIQIVHPPSCPECPLVCSTARGLRRHLEIAHGNVTLEERKIFHCTVPGCGRSFTKQGNLTVHIRTVHQGEKRFVCGETDLSNSNKLEGWDGVGCGKRYGNKLTLEDHIRTSHLGLPNARKRRQAKKTSKKPAQDSVSTLSALTGQGYAEETGRQIACFYPGSCPHRFHRNYDLWVHMTTKHSCTEDEVQNLFMQRALLTDETSAGVNSLGIYGLGYDQDGRSYCHQSYAAGDHSSDVAFGSQSNDSSYLPSQPGLDSDYLMADDSPARTAHSFFNTQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W6PRK5</accession>
    <name>W6PRK5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PROQFM164_S01g000627</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PRK5"/>
    <dbReference type="STRING" id="1365484.W6PRK5"/>
    <dbReference type="OrthoDB" id="2585655at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF29">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G06680)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="64"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM26818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="193" mass="20785" checksum="ACD934F80F4ECA0A" modified="2014-04-16" version="1">MALGIIQLNERHAPGTFLLFDESSTHVSSQTKFGTGKHASVVLIPQPSNSPNDPLPRWRKNLIYCVLFANSIIFSSIPPPLIAPSMVLMSHAVQRSIEDITMLTAYQLLACACYGPIGSALAHKYGKRPQFIFATIMGFIGTLVCCTTSDNYNVILAGRIIQGFSSAVFGSFTVAVMGDMCVSFTSDLSGLVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>W6PT39</accession>
    <name>W6PT39_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mitochondrial thiamine pyrophosphate carrier 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PROQFM164_S01g000715</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mitochondrial transporter that mediates uptake of thiamine pyrophosphate (ThPP) into mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PT39"/>
    <dbReference type="STRING" id="1365484.W6PT39"/>
    <dbReference type="OMA" id="YKMSVPK"/>
    <dbReference type="OrthoDB" id="270584at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24089">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 12" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="55"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="151"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="257"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDM26906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="354" mass="39124" checksum="91F996E41E38F3FB" modified="2014-04-16" version="1">MSLDRQDVQKEQLEGDPKPALQTLSKFPSSSNAAKELIKEKTPSIWVRTRKYLAEPMVAAFMAGGVAGAVSRTIVSPLERLKILLQIQSVGRTEYRLSIWKALVKMGREEGWRGFMRGNGTNCIRIIPYSAVQFGSYNFYKQFVESPDGEMTPMLRLFCGGLAGITSVTITYPLDIVRTRLSIQSASFAELGARDPSQKLPGMFTTITMIYKNEGGTKALYRGIVPTVAGVAPYVGLNFMTYESARKYLTPEGDKNPSSCRKLLAGAVSGAVAQTCTYPFDVLRRRFQINTMSGMGYQYTSIWDAVRVIVAEEGLRGLFKGIGPNLLKVAPSMASSWLSYEMTRDFFVGLNDGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W6PT69</accession>
    <name>W6PT69_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S01g000884</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PT69"/>
    <dbReference type="STRING" id="1365484.W6PT69"/>
    <dbReference type="OMA" id="QRMMHVT"/>
    <dbReference type="OrthoDB" id="5350192at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056004">
        <property type="entry name" value="DUF7582"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24483">
        <property type="entry name" value="DUF7582"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7582" evidence="2">
        <location>
            <begin position="39"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="323"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM27075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="400" mass="44092" checksum="1E4C1EAF043F40C7" modified="2014-04-16" version="1">MGAMRLPRPMGIYVPSSPRTLTGDMISPPLSPEFSFDSETVTPSLIPALEYISAKLQQRLMHVTLLIGRGKPYPTGQASDLMIIPIHSIEPQAWRVLERAIAKGSRKFSLGPSWTDALSRSQYERQANDHLVKQSILQNEVIFSQEGLTLLNMDRIYTFKRRMCILSTRPFSCNGGQSMSSCVRLLHRIVADFAGRPFSKAFFYRVYEQLDVPDEQLTAVAVAYKNVHNQDAIILPVQAKAPAPALTTASTAPSTAAALVSVPVPASVSAPVQAKVEATIPAKVTAKVQPKVQAEVQAKAQLKAAERVILKPKTDPIPIRVRAERPREVKRSPIQTVRGRRQPPSSRMRGHNKRGPKTPLSASDVTPITRNEWNILVSQDIRVQPKVTQWTPSPNVLAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W6PT73</accession>
    <name>W6PT73_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AMP-dependent synthetase/ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PROQFM164_S01g000760</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PT73"/>
    <dbReference type="STRING" id="1365484.W6PT73"/>
    <dbReference type="OMA" id="FIMGRTD"/>
    <dbReference type="OrthoDB" id="1706066at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050218">
        <property type="term" value="F:propionate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032387">
        <property type="entry name" value="ACAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43347">
        <property type="entry name" value="ACYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43347:SF3">
        <property type="entry name" value="ACYL-COA SYNTHETASE SHORT-CHAIN FAMILY MEMBER 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16177">
        <property type="entry name" value="ACAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acetyl-coenzyme A synthetase N-terminal" evidence="4">
        <location>
            <begin position="10"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="2">
        <location>
            <begin position="74"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="3">
        <location>
            <begin position="553"/>
            <end position="641"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDM26951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="700" mass="75589" checksum="D5A7CDDD256E5DDA" modified="2014-04-16" version="1">MSSHPQPTTHSHSLGDPETFWSHHAARLHWHRKPSRALTRQTKSLPSGTEHEHWSWFADGEISTTYNCVDRHVLAGHGDNVAIVWESPVTGVTEKYTYARLLDEVEVLAGVLREEGVKKGDVVIIYMPMIPAALVAALAITRLGAIHAAVFGGFAPQALAQRIEAARPKVLMTASCGIEGSKGPISYRPLVEGAVKASSFKPSRIIVWQRDQLRWDQPDKRGGQRNWQRLVKSARFRGVKAGPVPVKSTDALYIIYTSGTTGLPKGVLREAGGHAVGLELSIKSLFGIKGPGDTMFCASDIGWVVGHSYILYAPLLVGATTVLFEGKPVGTPDAGTFWRIVEKHNVNALFTAPTAMRAIRKDDPDDQLIGEVGKRGGLKSLRALFLAGERSEPGIVGSYQDLLRKYAADGALVIDNWWSSESGSPITGVALNGSAALASLASGPDHSPLTTRPGSAGFPLPGFDVRIVDDEGSEVPRGTMGNIVMAPPLAPSAFTTLFEDEERFYRGYLKRFNGRWVDTGDAGMVDEDGYVHIMSRSDDIINVAAHRFSTGSIEQAILSHPLISEASVVGIPDPLKGHLPFAFIQPKAGPITGKSNPLPATPTPQLFAEVNALVREQIGAIASLGGIIQGRGMIPKTRSGKTLRRVLRELVEYGVKGEYAAEINVPPTVEDAEVVSVARERVREYFEEKEKANGVGKAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W6PTF5</accession>
    <name>W6PTF5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Origin recognition complex, subunit 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PROQFM164_S01g001294</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ORC5 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PTF5"/>
    <dbReference type="STRING" id="1365484.W6PTF5"/>
    <dbReference type="OMA" id="QLRRWHG"/>
    <dbReference type="OrthoDB" id="365981at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005664">
        <property type="term" value="C:nuclear origin of replication recognition complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002614">
        <property type="entry name" value="Origin recognition complex subunit Orc5, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020796">
        <property type="entry name" value="ORC5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047088">
        <property type="entry name" value="ORC5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048866">
        <property type="entry name" value="ORC5_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12705">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12705:SF0">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14630">
        <property type="entry name" value="ORC5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ORC5_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orc1-like AAA ATPase" evidence="8">
        <location>
            <begin position="13"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="ORC5 lid" evidence="10">
        <location>
            <begin position="216"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="Origin recognition complex subunit 5 C-terminal" evidence="9">
        <location>
            <begin position="317"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="369"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF14630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF21639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDM27483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="529" mass="57107" checksum="2EF3B7E8004564EC" modified="2014-04-16" version="1">MLPKEVASSLSTQWPCRNVQMRQLASLLNPHVPSPPTLVVHGISATCKSTILRAVLATLEVPHAIVRSSECITGRHLLTKILWNTLEALGQKEEWETSGKGRCEHVSGLAVLLEECLAARPVQTLGKFVLVLDEIDRQREAPHTLLSALARLGDIIPSLCVVLVLSSTPRPLFLQSAAVPHVSFPPYTRKEAIHIILSSDAPVVDGLPDETSSRVYPYFVSTVYDSLVGPTAGSIPDFRSICERLWPRFVAPVVNGETPPGGNSEWDFSRLLVKNRVIFRHQGESALVHHIVPDETPAGEKRTTLAKTAMPSALPSLPYFSTLILTSAYLASHTPQRLDTIFFSKFSSSSLSARNKRAHHRRRLKVLSQAQAEERQAANDDPSTPNKKGKRTKTRITKSTLSSAFATSSATTSAVGGGAGIAGPSTILTARSFPLERLLAIYHAIDPNPPATPLRVSAVADRIYAELATLRRLRLVVPAASHNAMATSSGNTTADAGDKWCVNVSGDWVGELAKGIGVEVGEWLAGGLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2024-10-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W6PU55</accession>
    <name>W6PU55_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g001216</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PU55"/>
    <dbReference type="STRING" id="1365484.W6PU55"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004879195" evidence="1">
        <location>
            <begin position="25"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM27405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="50" mass="5381" checksum="1993BBF3FBB36BC9" modified="2014-04-16" version="1">MANPSLACMRLCLAVLRAATVACGLSIGNHTSSLACRCMPHDPCWPEDHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W6PUQ1</accession>
    <name>W6PUQ1_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Carboxylesterase, type B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S01g001307</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PUQ1"/>
    <dbReference type="STRING" id="1365484.W6PUQ1"/>
    <dbReference type="ESTHER" id="penro-w6puq1">
        <property type="family name" value="Fungal_carboxylesterase_lipase"/>
    </dbReference>
    <dbReference type="OMA" id="FRYMADW"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050654">
        <property type="entry name" value="AChE-related_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918">
        <property type="entry name" value="ACETYLCHOLINESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918:SF4">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="3">
        <location>
            <begin position="14"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="3">
        <location>
            <begin position="290"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM27496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="424" mass="46669" checksum="397158631496432A" modified="2014-04-16" version="1">MYSVSKLVDYPDKTPQFDSIFEAFAAINNNTQSEDCLTLNIWSKPDSNQLKPVYVHFYGGRWTSGTTDTPFYYGGGFAGTEDVIVVTVNYRMNIFGFPGLPGHPPNLGLLDQRLAVEWVKQNIRGFGGDPNRITISGQSCGSASVDYWAYAYQSEPLVTGLISHSGTALSFPTNNRTTAAEHWYTVSAQLGCGSSGDVLPCMRKQNASAILAAASAVKVPTTNPARKSPAFQPTVDDVTVFENYTLLSQQGKFARIPYLVGHNANEAGFYKIATYAQGSTLTDEQWDDFNMQTFFCPSNLEAAHRSRRHTPVWRFQYNADWENTRLYPTSGAYHGVEFNMIFGESAEITGIAESDAQRQLQVQMRSAWGSFIADPEHGLKALGWPSYDPDASTLVEIGLDNRPSVSFVGTENSAQRCAALLAQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W6PV93</accession>
    <name>W6PV93_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g001974</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PV93"/>
    <dbReference type="STRING" id="1365484.W6PV93"/>
    <dbReference type="OMA" id="WPENILR"/>
    <dbReference type="OrthoDB" id="2351940at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="372"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM28163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="503" mass="57104" checksum="3A1574FB15A998D5" modified="2014-04-16" version="1">MSGNYDYPRASSSSTRRSRISRHSRPDERPDILRLQHLRNLVSERTRSGSYNAYNTNFALETLNREIAAHSLDRSRDRTNLEQARADVDRQLHSETTGPAEPTRSIWLDQIRSERARTSLSPESHSLRHRLPWQTFRPPSPDGSLSRSPSFMPPSGQSGRDGQGRMKRRKLDTDDNREEFRGFNYGQYGQVLPGMLQMEIASCDGGSYDPDSGCSRPENVLDNNTSVYSTREARCNLVLCHRGEAPFCLKKIVIRAPQCGFDAPIQEGMVFVAMTSDELLARTAQYQIQYSSGRYRRRARRSGMQPSQEYLTGFRPPLQNIERTVLMSPHSAAVPHTAEDPQAQFRITTEYDNNEDSGDDEESSAFLERTQADQMEDPLSSTDESPSDEDDSSRHQSRRQVQSERLSALSRVSEQRLRHSPSLVHPHPLAEPAHPTAEVLKPHARFFIEREKSMVTIKFDPPPSGRFILIKLWSPRAHGNIDIESIIAHGYAGPRFFPSLASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W6PVE1</accession>
    <name>W6PVE1_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Rossmann-like alpha/beta/alpha sandwich fold</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PROQFM164_S01g001666</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>beta-nicotinamide D-ribonucleotide + ATP + H(+) = diphosphate + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:21360"/>
            <dbReference type="ChEBI" id="CHEBI:14649"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="EC" id="2.7.7.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; NAD(+) biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PVE1"/>
    <dbReference type="STRING" id="1365484.W6PVE1"/>
    <dbReference type="OMA" id="RLVMMEL"/>
    <dbReference type="OrthoDB" id="5591297at2759"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000309">
        <property type="term" value="F:nicotinamide-nucleotide adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd02165">
        <property type="entry name" value="NMNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005248">
        <property type="entry name" value="NadD/NMNAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31285">
        <property type="entry name" value="NICOTINAMIDE MONONUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31285:SF0">
        <property type="entry name" value="NICOTINAMIDE MONONUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="2" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cytidyltransferase-like" evidence="10">
        <location>
            <begin position="46"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="238"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="243"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDM27855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="285" mass="32245" checksum="C5C39F21F2E2F825" modified="2014-04-16" version="1">MSSFQALRTQYASRLKAFTTSTKVFEVLTTIPSGPSADPETLYVLDSSFNPPTRAHLRIVSTALLENSRPRRRLLLLLAIHNADKPSKPASFEDRLAMMELFARDLRPQLASAPAFEHAVENIPLIDIGVTKKPYFIDKAAAIEASDSYPTPMEQVHLMGYDTLIRIFDLKYYPPEHNLKSLAPLFSKHRLRVTMRPSDGWGGREEQEEFLAALARGDRDSDGARREWADRIQLVEGRRPTDQPVSSTRAREASQSAPQDLEWLVPEQVRQFLLSEHLYSGNSKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W6PVT0</accession>
    <name>W6PVT0_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Survival motor neuron</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PROQFM164_S01g001821</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SMN family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PVT0"/>
    <dbReference type="STRING" id="1365484.W6PVT0"/>
    <dbReference type="OMA" id="MMSWYFA"/>
    <dbReference type="OrthoDB" id="197400at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22852">
        <property type="entry name" value="SMN_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22851">
        <property type="entry name" value="SMN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040424">
        <property type="entry name" value="Smn1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047313">
        <property type="entry name" value="SMN_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049481">
        <property type="entry name" value="SMN_G2-BD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39267:SF1">
        <property type="entry name" value="SURVIVAL MOTOR NEURON PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39267">
        <property type="entry name" value="SURVIVAL MOTOR NEURON-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20636">
        <property type="entry name" value="SMN_G2-BD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20635">
        <property type="entry name" value="SMN_YG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Survival Motor Neuron Gemin2-binding" evidence="7">
        <location>
            <begin position="13"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="59"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="100"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM28010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="158" mass="17544" checksum="687DD376B3FB6226" modified="2014-04-16" version="1">MGKNKKKVTLTHAEVWDDSALVQSWDDAVEEYQHYWSIHAKGENVEDVLRATEDTGVVPAIHDSDIQSTKPVEDGANKTQNEDVSIVDEQISEPVPEPSQPVAAASPAVSTPAMPMPHPIMANVQDESLKHLMMSWYYAGYYTGLHEGQQQASRDQRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W6PVU9</accession>
    <name>W6PVU9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PROQFM164_S01g001841</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PVU9"/>
    <dbReference type="STRING" id="1365484.W6PVU9"/>
    <dbReference type="OMA" id="FDQFRIF"/>
    <dbReference type="OrthoDB" id="3971593at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051209">
        <property type="entry name" value="FAD-bind_Monooxygenase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877:SF10">
        <property type="entry name" value="L-ORNITHINE N(5)-OXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="573"/>
            <end position="590"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM28030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="620" mass="70463" checksum="8036A665DE67CFFD" modified="2014-04-16" version="1">MPSSITQIHKRHAYGKDAHTYYPVLIVGAGESGVAMGCRLKEVLGTDQFRIFERQSGIGGTWWINRYPGIACDVPATFYSFSFALKKDWSTLHPPGPEIAQYLADVCERYQIVDKIQLNTDVKELRWIGDDEEWEVTLSHLVPGTGDLTQHERDRIAAQDGHQKIYVNTEIVRAKVVVSGVGGLVEPNTWPKDIPGIEHFEGDIMHTARWNNQIDLKDKNVIMIGSGCSAAQVVPELAKPEANVRSITQLMRTPPWVEPDTISPEYLPVYEKWSPRLVTNLPGLALFMRCVVFLIMEKNFQDMFTDTAWSRRARPQLEKKFLDHMRQIAPEKYYEILTPNYSLGCKRRVIGGTWYRSLNAPNVELTTQPLTRVNAKSVTLGTGRHYPPHKSEDAVEVREIPADVIIMANGFETNQWLHPLKVIGREGKDLEEVWAERGGAQAYQGIAMDSFPNFFIIFGPNTATGHTSVIFATENAVNYSLNFIKPILDGQVSSYEVKEDAEREWTQQVQDALQKSVFRRGACSSWYITADGWNSTTYPFTQVHYWLRCKFPVWRHWTAKLTRKGRILRGVRMTLHGALIFGLITTIGFLRKNPQQKAQLEQSLLAGKEWLASAVSQLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W6PXK7</accession>
    <name>W6PXK7_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dimeric alpha-beta barrel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S01g002332</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PXK7"/>
    <dbReference type="STRING" id="1365484.W6PXK7"/>
    <dbReference type="OMA" id="QIATWKE"/>
    <dbReference type="OrthoDB" id="42919at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013097">
        <property type="entry name" value="Dabb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044662">
        <property type="entry name" value="HS1/DABB1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33178">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33178:SF19">
        <property type="entry name" value="STRESS-RESPONSE A_B BARREL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07876">
        <property type="entry name" value="Dabb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00886">
        <property type="entry name" value="Dabb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51502">
        <property type="entry name" value="S_R_A_B_BARREL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Stress-response A/B barrel" evidence="2">
        <location>
            <begin position="3"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM28521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="100" mass="11059" checksum="C5FAAD4CE3EE740A" modified="2014-04-16" version="1">MPVYHIVLFRLKSGVTPAQIATWKETCQGMVGKIPGLLSLQNGPPLPISIPRAHGFDMGLVAVLETPEHVATYAVHPAHLEVHKMREELCDDTLAYDLEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W6PXV8</accession>
    <name>W6PXV8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S01g002894</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PXV8"/>
    <dbReference type="OrthoDB" id="4349400at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM29083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="76" mass="8019" checksum="89C1D06ACA5B2FAA" modified="2014-04-16" version="1">MPESIFDPSPGNPLAQSAISAYTHAMQTYTLSQISSLDPSKIHEISDRVSDDISIIGVLFKGPGHPPIAAEAKEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W6PXW3</accession>
    <name>W6PXW3_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Pyridoxal phosphate homeostasis protein</fullName>
            <shortName evidence="2">PLP homeostasis protein</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PROQFM164_S01g000618</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Pyridoxal 5'-phosphate (PLP)-binding protein, which may be involved in intracellular homeostatic regulation of pyridoxal 5'-phosphate (PLP), the active form of vitamin B6.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PXW3"/>
    <dbReference type="STRING" id="1365484.W6PXW3"/>
    <dbReference type="OMA" id="PLEWHMI"/>
    <dbReference type="OrthoDB" id="10264196at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06822">
        <property type="entry name" value="PLPDE_III_YBL036c_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.10:FF:000007">
        <property type="entry name" value="Pyridoxal phosphate homeostasis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="entry name" value="Alanine racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02087">
        <property type="entry name" value="PLP_homeostasis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001608">
        <property type="entry name" value="Ala_racemase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011078">
        <property type="entry name" value="PyrdxlP_homeostasis"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00044">
        <property type="entry name" value="YggS family pyridoxal phosphate-dependent enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10146">
        <property type="entry name" value="PROLINE SYNTHETASE CO-TRANSCRIBED BACTERIAL HOMOLOG PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10146:SF14">
        <property type="entry name" value="PYRIDOXAL PHOSPHATE HOMEOSTASIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01168">
        <property type="entry name" value="Ala_racemase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004848">
        <property type="entry name" value="YBL036c_PLPDEIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="PLP-binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01211">
        <property type="entry name" value="UPF0001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alanine racemase N-terminal" evidence="5">
        <location>
            <begin position="47"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2 3">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR004848-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDM26809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="279" mass="30155" checksum="F6DE2B92BCF89F23" modified="2014-04-16" version="1">MTTNTPSQPPTMNPATPARASTLLSNLTSVRARVSTAALQSPIPSKPIRLVAVSKLKPASDALALHQAPGSQVHFGENYLQELLEKSRLLPASIKWHFIGGLQSNKCVTLARDVRGLWAVESVDSEKKAKLLDKGWGERGAEVAATNHDEDGRLRIYVQVNTSGEENKAGVEPAAAPALCRYVREQCPRLKLQGFMTIGAIARSRATTVENENEDFVCLRETRDRVVKELGLVGDEAELELSMGMSSDFEGAIALGSDQVRVGTTIFGDRPPKAEANVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2024-10-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>W6PZ63</accession>
    <name>W6PZ63_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S01g003370</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PZ63"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM29558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="96" mass="11375" checksum="58B972070129B498" modified="2014-04-16" version="1">MIIALMAQAMDLEYSDSMIEMTKNTLRSCNEIPKTFIFHGHTTLHSRGSFLWCPYNLFDRNLAVTLAWDKRHKEMFIWRIRNVEMMTEGWSKSDKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W6PZQ5</accession>
    <name>W6PZQ5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Allergen V5/Tpx-1-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S01g001250</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM29831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="1981" mass="218506" checksum="AC93C4CB7C95A800" modified="2014-04-16" version="1">MSSRFPPSSGFNPRDRSPQRFGDRRPPAGPRGPDDGPAPFGRDPPRGPRALVDSPRGGHFGGRGRGYGRGDFRDRDRDPRDRDRDRDFRDNRDGPPFRRDMDRDWVRRDRDFDPRDNRIGFGRGRSRSPTRDFRDIREPPGRDFDLVRIRRNSRDSIISASSGGPEGPPPNIGHMHRGGMRGRGRGDWEGGRGRGRPPFLDDRDLFRRRSRSREPWRGRDRMVDRDRDRDMDRDRALDRDRVMDRDRDRDLPRPRERDRELDRDLDRRDRFDRREDWDNRRPDREDRDRPVDFWKRDRPPSRADSRAASGSTTSSHAPTAPGPGPGPTLADRLPEHPQVDHSRKSSTILSTTALETTRDSEGNDPIAVRTSGTRLDAVRPEAVRPEAVRPEAVRPDVVRSDVVRPHASRLDAVRPDAVRPHPRPAAPRSDAVRSDGMKNPGPIIRNSPPPAAPQVPAFGSVTSPITNASSNKVFSDQRTAPNSTLPTERDRYEVPQRQPAQPPTGPKAERIESIQPLEPRSRPERPRETGKHQVVPPRLSKPSINFPDVSPPTAPAAMTRPDPGAGPNEGFGAGRSNSLTSSPTFSRIPPPAPRALSREPSMSPQMQSSGIPTGPRALQWKAPSPRGRKGSKQWVRPGYGRIPSISNALPKQEPVEESEGVSPANEATRPLLAPEIDDPESGEILPHEPAREPSPVSPPLNLPPRRSLSAVDIQTSDANEPSEMSGTDKPALIPDFEGSSDEEDGENIVFTQEYLDDRKRIFEKDMESLRAELPPSPLEDSAIVALLLKIQLLGMVANEKTVENPPEPLAEPPTERVLEQPVDPVPSVEDEEPVDHSTTERVVSFPSTPPEREPEPITETIIPPMVPPDEVTIESLPFLHSGPPIPISDMDVYHENITIQNRLRDTFSTELSKVQARTFRKNALLRDEYVSHYKLWRMAIWELDRMKEKKSVTPGPAFSPISTVPTTPAPMPEGREGRRYKGNSELDFLNALKASEISAQEELERRRIKMATARPDLGREAIIPNMLEPREVKARIYKDVNNNIECNMALDVFGFVPPPNDFTPEEHIIFTDAFMAHPKQWGKIAESLPGRNFQQCIVHYYLTKEEIKYKAKLSKRWNKRSKGTRKGPRPKSNALTADMGVVKPDHVGEEEPPAVTDTGRPRRAAAPTFGDSTEVESTPIGRRGQLGKDGEPVDRPSTRRGGRGGGTRGARRVKSTTQPDPKTHVVMPQGNLPPIVPPTPLHPGSEMDLASDHILEGYEAREQERSEKESIPPISRGRVGRGRAKEGVYVFESTEVEPFLGTKQLETGYGSLQPTSYWSVPEQRDFPALLGHFGRDFEGISGWMKTKTTVMVKNFYQRRLDSGQKDFELILTDAEEKKARGEATGPLPVPSVAPKRRYEATPSSIIPRPLAPHGDPMAEVDEIRFPKGKPVGLSPQPMSLHGRPLSDKDRNVGRYQPLAQASAASPVPSTATLIEESTRAIRAQGGPSHRVQGPRLGYFTEDRRDSSGLPHGASRAQELAISSRHPDSMPTDMARMEPLSTQGYIPAQQPTSHLSSTHSRHASLTQTPGSPSLQLRPELDISSVHRDPFAQRPYYSLAGQPMGLPQSPRPGLSPVKDVPRPSATPAPDATRQVPAKRSNIMSILNDEPEEPQPRKRFASEQAPSVPGATSGINPRPIYQASGPPRHEDNIMSGMSQKPSGYAQQSQYQPSSRGYSEYSGYGPPHGGSGTSNNDWMARFDPRAQQTPPQPQAPSLPPQQQQSGRQGSYSSYAANPGQSSLTNLSAPSPAPTPPPINASQRSAYPNVFSQGSSAQPPMASGSRDMASQPGSYRQGSPGPRPGMVYGSRQDPPTPAQSSASLYGMHPRQSATPNPVQPHSYQQHVQTMYGHNTPPPQSQAGRSMASLASLGRSYTPPSALHSSMSGGTMGGYAPPQSSAPGSIPPLHQRPPGSLGDPVSTQTHHRVYSHGSAQGVLPPPSQPPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q297</accession>
    <name>W6Q297_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cytoplasmic tRNA 2-thiolation protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ncs2</name>
        <name evidence="3" type="synonym">CTU2</name>
        <name evidence="3" type="synonym">NCS2</name>
        <name evidence="4" type="ORF">PROQFM164_S02g000818</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with NCS6 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CTU2/NCS2 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q297"/>
    <dbReference type="STRING" id="1365484.W6Q297"/>
    <dbReference type="OMA" id="KQRKQMM"/>
    <dbReference type="OrthoDB" id="25129at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016783">
        <property type="term" value="F:sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032447">
        <property type="term" value="P:protein urmylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002143">
        <property type="term" value="P:tRNA wobble position uridine thiolation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03054">
        <property type="entry name" value="CTU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019407">
        <property type="entry name" value="CTU2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20882">
        <property type="entry name" value="CYTOPLASMIC TRNA 2-THIOLATION PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20882:SF14">
        <property type="entry name" value="CYTOPLASMIC TRNA 2-THIOLATION PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10288">
        <property type="entry name" value="CTU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM30668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="369" mass="40684" checksum="DB9DF75D9563CEEC" modified="2014-04-16" version="1">MPAKELSKSCMECKDAEFDLIARKRQLCSSCFRRFIAHKVQSRLSVYRAFGLDGPKTQLLLPVSFGVSSSVLLHILNTDRQHRLDNGRPLGYDFKILIIEPSTVAATGVPFDKNYEALEKNFPMHTISRIPFHSIFDYVPEVEDIMQEYAGSKFTDDSTRSNEDRLAAFRASISTPTSRADVDTVLLTRLIVEFAKKSGCESVIWGDSDSRLAAKALAGVAKGRGASLTWQVSDGMSPWGVRFEYPLRDLYKAELLQYASVCAELSDIVIPDQPPSENVLTKNLSIDELMLRYVQNQGAKYPGVMANVARTANKLNPSTSDNAPTCALCASLVGNVQGNSGVTVANQAEDNHSSQFCYGCMRSRPGELC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q2F7</accession>
    <name>W6Q2F7_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small ribosomal subunit protein uS2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">rps0</name>
        <name evidence="6" type="synonym">RPS0</name>
        <name evidence="10" type="ORF">PROQFM164_S01g002195</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (25S, 5.8S and 5S). Interacts with RPS21.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6 7">Belongs to the universal ribosomal protein uS2 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q2F7"/>
    <dbReference type="STRING" id="1365484.W6Q2F7"/>
    <dbReference type="OMA" id="QCHLGAK"/>
    <dbReference type="OrthoDB" id="414863at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01425">
        <property type="entry name" value="RPS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10490:FF:000010">
        <property type="entry name" value="40S ribosomal protein S0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10490">
        <property type="entry name" value="Glucose-6-phosphate isomerase like protein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03015">
        <property type="entry name" value="Ribosomal_S2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001865">
        <property type="entry name" value="Ribosomal_uS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032281">
        <property type="entry name" value="Ribosomal_uS2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018130">
        <property type="entry name" value="Ribosomal_uS2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027498">
        <property type="entry name" value="Ribosomal_uS2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005707">
        <property type="entry name" value="Ribosomal_uS2_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023591">
        <property type="entry name" value="Ribosomal_uS2_flav_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01012">
        <property type="entry name" value="uS2_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11489">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN SA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16122">
        <property type="entry name" value="40S_SA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00318">
        <property type="entry name" value="Ribosomal_S2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00395">
        <property type="entry name" value="RIBOSOMALS2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52313">
        <property type="entry name" value="Ribosomal protein S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00963">
        <property type="entry name" value="RIBOSOMAL_S2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS2 C-terminal" evidence="9">
        <location>
            <begin position="205"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="259"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="259"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDM28384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="303" mass="32394" checksum="5EA8AA5B99747AA6" modified="2014-04-16" version="1">MAPSQLPPVFNPTAQDIEMLLAAQCHLGSKNLQVHMEPYLWKLRADGVNVLNIGKTWEKIVLAARIIAAIDNPADVCVISARPYGQRAVLKFASHTGATAIAGRFTPGNFTNYITRSFKEPRLIIVTDPRTDSQAIKEASYVNIPVIALCDTDSPTDFVDVAIPTNNKGRHAIGLVWWMLAREVLRLRGTLATRETEWDTVVDLYFYRDPEAEENKEIADEAKVPGADEIGAGAVESGFAGENWDASAPGAGNPGTAFAAASAATATAGATSWDAEGGDWAASSAPATTEWAEAQPAAGEAKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q2M6</accession>
    <name>W6Q2M6_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">hydroxyisourate hydrolase</fullName>
            <ecNumber evidence="5">3.5.2.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PROQFM164_S02g000725</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the hydrolysis of 5-hydroxyisourate (HIU) to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>5-hydroxyisourate + H2O = 5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23736"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18072"/>
            <dbReference type="ChEBI" id="CHEBI:58639"/>
            <dbReference type="EC" id="3.5.2.17"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.17" evidence="5"/>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q2M6"/>
    <dbReference type="STRING" id="1365484.W6Q2M6"/>
    <dbReference type="OMA" id="CSENQNY"/>
    <dbReference type="OrthoDB" id="10265230at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033971">
        <property type="term" value="F:hydroxyisourate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006144">
        <property type="term" value="P:purine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05822">
        <property type="entry name" value="TLP_HIUase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.180:FF:000006">
        <property type="entry name" value="Probable 5-hydroxyisourate hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.180">
        <property type="entry name" value="Transthyretin/hydroxyisourate hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014306">
        <property type="entry name" value="Hydroxyisourate_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023416">
        <property type="entry name" value="Transthyretin/HIU_hydrolase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036817">
        <property type="entry name" value="Transthyretin/HIU_hydrolase_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02962">
        <property type="entry name" value="hdxy_isourate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10395:SF7">
        <property type="entry name" value="5-HYDROXYISOURATE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10395">
        <property type="entry name" value="URICASE AND TRANSTHYRETIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00576">
        <property type="entry name" value="Transthyretin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49472">
        <property type="entry name" value="Transthyretin (synonym: prealbumin)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0659">Purine metabolism</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transthyretin/hydroxyisourate hydrolase" evidence="8">
        <location>
            <begin position="49"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM30575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="182" mass="19793" checksum="A88880A84453D0DB" modified="2014-04-16" version="1">MDSPQNNQQLGRTTNRLALYQQQISPAPHTKDANPIKQPTTTMAARDPITCHCLNTLSGTPAANLPVTLTLLSTPASTASSISFRATTNADGRVANWTPVGTASESVPAILAALPAADSKTNWSVRFDVGPWYEAQGVESFWPEVEVKFTVKGRGREGEEGWRHYHVPVLLGPWNYSTYRGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2024-10-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q2P3</accession>
    <name>W6Q2P3_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S01g002295</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q2P3"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM28484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="91" mass="9810" checksum="C7CCC9E811B7D1E9" modified="2014-04-16" version="1">MAGSGIHSMDADRGITGPCVGILQLYSDIALRTDYGIRTSAILSASSSGFPILRECHTRFHTTMQNAWGGKTKLFATGSTTKESIPYIKSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q309</accession>
    <name>W6Q309_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">LSM complex subunit LSM5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LSM5</name>
        <name evidence="13" type="ORF">PROQFM164_S02g001108</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Plays a role in U6 snRNP assembly and function. Binds to the 3' end of U6 snRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the heptameric LSM1-LSM7 complex, which consists of LSM1, LSM2, LSM3, LSM4, LSM5, LSM6 and LSM7. Component of the heptameric LSM2-LSM8 complex, which consists of LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8. The LSm subunits form a seven-membered ring structure with a doughnut shape.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">LSm subunits form a heteromer with a doughnut shape.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q309"/>
    <dbReference type="STRING" id="1365484.W6Q309"/>
    <dbReference type="OMA" id="YETTPQG"/>
    <dbReference type="OrthoDB" id="429711at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990726">
        <property type="term" value="C:Lsm1-7-Pat1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01732">
        <property type="entry name" value="LSm5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000003">
        <property type="entry name" value="U6 snRNA-associated Sm-like protein LSm5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033871">
        <property type="entry name" value="LSm5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20971">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20971:SF0">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="3 11" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7 11" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 11" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 11" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="12">
        <location>
            <begin position="6"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU365055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDM30958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="83" mass="9010" checksum="58458E097A78AD3D" modified="2014-04-16" version="1">MASQLLPLELIDKCVGSRIWVVMKGDKEFSGTLLGFDDYVNMVMEDVTEFDYTGAQIKLPKLLLNGNNICMLIPGGEGPAASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q335</accession>
    <name>W6Q335_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S02g000530</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q335"/>
    <dbReference type="STRING" id="1365484.W6Q335"/>
    <dbReference type="OMA" id="DQSARIY"/>
    <dbReference type="OrthoDB" id="8300194at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM30381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="189" mass="21574" checksum="C60000580965F3CB" modified="2014-04-16" version="1">MKVRYLSRINAQKHQEHYNSDERGLCDQSARIYPADEGGRDVFALGSIIVKSSHLHGQGAEHIEIDYSYAGTNEIQAIAIAKNVLKDIRVPDIYFTGKINGGPIIVQERLPDVSLAIAWQYLSQAQRDSFKQQAREILRQLHSVKPTDGYQIRSYVVPDPKIRQNGRIQPLECEILFRSGYKLHAQRLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q3W7</accession>
    <name>W6Q3W7_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Saccharopine dehydrogenase / Homospermidine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S02g001433</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the saccharopine dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q3W7"/>
    <dbReference type="OMA" id="GPYQLYG"/>
    <dbReference type="OrthoDB" id="10268090at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009247">
        <property type="term" value="P:glycolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051276">
        <property type="entry name" value="Saccharopine_DH-like_oxidrdct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005097">
        <property type="entry name" value="Sacchrp_dh_NADP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12286">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE-LIKE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12286:SF5">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE-LIKE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03435">
        <property type="entry name" value="Sacchrp_dh_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="281"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="353"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="Saccharopine dehydrogenase NADP binding" evidence="3">
        <location>
            <begin position="10"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM31283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="412" mass="45064" checksum="46012B9FDA48296F" modified="2014-04-16" version="1">MTSNRQYDLVLLGVTGYTGRFCAEHIVQHLPTDLKWAIAGRSAEKLESIAQELKGLNPDRVDADVLVVQLNSIELNELALKTRLVINCVGPYHLYSTPVVEACAVNGTHYVDVSGETPWIKSIIEKYHETAKANGAIMIPCNGVESAPADLLAWSLVKRVREDLASSTRQIDSTIKEMRSSGPSGGTINTILTIFEGFSMSELSKSMTPFSLAASPPPKNIPRDSILEKIFGVRSIRDLGTVTTSPSGICDITIVQRSSSLMPELYGQQFVFRQFLSVRNALVGVAIHIGFLVALSLLALSPVRWLVKKFVFAPGSGPRREDSTNDLLEYHAIATAESAPVQRVFGKITYHGAMYPFTGLLLAEAAMVILNEEEKIKKVSRGGIVTPATLGQDYVDRLERVGCIIDTKVLQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q4A1</accession>
    <name>W6Q4A1_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Amino acid/polyamine transporter I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PROQFM164_S01g002805</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q4A1"/>
    <dbReference type="STRING" id="1365484.W6Q4A1"/>
    <dbReference type="OMA" id="FLDYGMI"/>
    <dbReference type="OrthoDB" id="10062876at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF6">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="81"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="128"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="188"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="282"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="309"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="342"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="387"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="465"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="490"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="7">
        <location>
            <begin position="52"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM28994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="559" mass="61776" checksum="4858854CE2F7C37D" modified="2014-04-16" version="1">MSASKYFEKGPPSPSIATEPSSKIDDDVQPGMSANISSGSQHLHRKLRGSEVQLFAIGGAIGTSLYVQMGQALPKGGPAGLFIAFFIWGAVMWAVNECFAEMVTYLPVPSPFIRFGSEWVDGALGFAMAWNFFLNMAFLVPFEIVAMNIMITFWTDKVPVEAIIVAMIVLYAILNVATVRYFGISEFYLSIFKVILMLGLFFFTFITMLGGNPLHDRYGFRYWNHPGAFVEHIVSGGTGKFLGVLSCVYQASFSICGPEYISMVAAETENPRKILPPAYRSFVWRILLFFVGSALCMGIVIPYNDTTLMGILGGSLTGSGTGAASPYVIAMQRLKINGLPSLVNALIMTSIFSAGNGLLFSATRTLHGMSLEGHAPRFFSWCTKAGVPLWALLFSLSFCLLAFLQVSSSSANVMNYLVDLVTCCQLINYLCTAATYRHFFSSLKRQGISRDTLPYKGRFQPYTSYFAMGGTLFMLLAGGYDVFIKGGWDVMWFCLDYAMIGFFIVLFLFWKIVFRSRYVWPGTADLSLGGIKEEIDQYEAALIPREQGLVDKVVGKIFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q4S7</accession>
    <name>W6Q4S7_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="7">D-lactate dehydrogenase [cytochrome], mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">DLD1</name>
        <name evidence="7" type="ORF">PROQFM164_S01g003006</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-binding oxidoreductase/transferase type 4 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q4S7"/>
    <dbReference type="STRING" id="1365484.W6Q4S7"/>
    <dbReference type="OMA" id="GQGFEWA"/>
    <dbReference type="OrthoDB" id="7786253at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004458">
        <property type="term" value="F:D-lactate dehydrogenase (cytochrome) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008720">
        <property type="term" value="F:D-lactate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903457">
        <property type="term" value="P:lactate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.465.10:FF:000014">
        <property type="entry name" value="D-lactate dehydrogenase (Cytochrome), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2740:FF:000001">
        <property type="entry name" value="D-lactate dehydrogenase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004113">
        <property type="entry name" value="FAD-bd_oxidored_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11748">
        <property type="entry name" value="D-LACTATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11748:SF116">
        <property type="entry name" value="D-LACTATE DEHYDROGENASE (CYTOCHROME) (AFU_ORTHOLOGUE AFUA_7G02560)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02913">
        <property type="entry name" value="FAD-oxidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="FAD-linked oxidases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="6">
        <location>
            <begin position="158"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM29194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="586" mass="64063" checksum="6ADB2FF137903482" modified="2014-04-16" version="1">MVFNALALGARSLRTRPSPRLVRHFAASAKQAKENQSFKSQLYESTQQRLKRERAEQEKFAQYQTQSPAGRSAALIFALVFFSTGAYYLGSLKPAALPTTSTTPLSDIGPAKHNVSISNLQAAWADFVEILGKENVSTSVGDVEMHSGSDWSSYTPKEGEKPFLILYPSTTEEVSRIMKICHQRIIPVTPYSGGTSLEGHFASTRGGVCVDFRRMDRILALHKPDMDVVVQPAVGWEELNAEIAKDGLFFPPDPGPGAMIGGMVGTGCSGTNAYRYGTMREWVLSLTVVLADGTIIHTRQRPRKSSAGYDLTKLFIGGEGTLGLVTEATLKLTVKPQSENVAVASFGTIHRAAECVTKVVEAGIPVAGVEILDDVQMKCINASGTTSRQWKESPTLFFKFTGTPNAVKEQIGLVKKIVSTTSGNSFEFARDQDEMAELWSARKEALWSVLAMKKNPDDHVWTTDVAVPISRLPDIIEATKEDLTKHGLLAGICGHVGDGNFHSIILFSETERSIAEGVVHRMVKRAVEMEGTVTGEHGVGLVKRDYLEHEVGVTTVDTMRRVSLDIHSHSTPDSKYTFVYTHGAYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q4W5</accession>
    <name>W6Q4W5_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">EKC/KEOPS complex subunit BUD32</fullName>
            <ecNumber evidence="5">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14 15">Atypical Serine/threonine protein kinase BUD32</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">EKC/KEOPS complex subunit bud32</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">PROQFM164_S02g001161</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. BUD32 has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit KAE1. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptional coactivators.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the EKC/KEOPS complex composed of at least BUD32, CGI121, GON7, KAE1 and PCC1; the whole complex dimerizes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Host cell</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="5"/>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q4W5"/>
    <dbReference type="OMA" id="HGFAPWE"/>
    <dbReference type="OrthoDB" id="8596411at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043657">
        <property type="term" value="C:host cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051138">
        <property type="entry name" value="PIM_Ser/Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22984:SF25">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22984">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE PIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0158">Chromosome</keyword>
    <keyword evidence="11 21" id="KW-0418">Kinase</keyword>
    <keyword evidence="10 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="13" id="KW-0779">Telomere</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="20">
        <location>
            <begin position="145"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="528"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00019973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00033194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="CDM31011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="579" mass="66293" checksum="3C746A09A79477CE" modified="2014-04-16" version="1">MTEQMGVNEQDPYAFDYILGRDLGAIKGNHTLHHPSSQAREFKYQDYDDSFSYNAERLLDPSSRLSERYPQVSQVLRERLGVAFGKRNNEEFSRCNCRDDSGHRCDSEVFQKCNSTSYGDFIRLSAEGRTTAKAVCLCPHLIERVQIYGFIGAGTFGATFIAREKGAAGASLEDLQQFAIKSQIHTTQWMDTLSGVNAQMGPFYEASGEKRYMPEEALLLIYLDDSPRFPRLNSVYTHGMLTAILMTPCVDPSYEAISVIDEGHFNRIKSKGAIPPRIRKRYPPFPSFDGSYLMSAATKEPQLGEIEGCKVASQLLQAMVELADMKVCHADISVTNYLMDQNLNVQLIDLGMLYFSLEKSGFAMKIDHFIPYQEYQMMPERAIELEKYDIWRDPSHDDVSIESIYLPVDQRDICLWKYSTLVYGFLHGFWAWDEPKPVPRSLNWHARYDGSYNDLFYPVVKRRRKRMINEDVAISESLSQDCRDVLQATLARDKFDRPSLEELSSFPWFSRWSAEELESGRPSKRPFIKKFHDKTRADGRRGFPWPSISQDQGISIPILNSPRYNSSGSSSASDDCEYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q5A7</accession>
    <name>W6Q5A7_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Zinc finger, C2H2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S02g001974</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q5A7"/>
    <dbReference type="STRING" id="1365484.W6Q5A7"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="97"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM31823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="133" mass="14828" checksum="7223E369B0AC5578" modified="2014-04-16" version="1">MKYKRRGKGKPNGQQPQDTGHHCTVCKSRQFKTEQGLSDHFKCQHAIFPCSDCNEIYAAAVELAEHRYSAHNKGTFNKRYRVSPNNHLPTAKGNATSRPRAASSPAIPGFLSTTKVPVHLRLLPSRTRSASRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q5E4</accession>
    <name>W6Q5E4_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Integral membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S01g003231</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q5E4"/>
    <dbReference type="STRING" id="1365484.W6Q5E4"/>
    <dbReference type="OMA" id="HETMTHH"/>
    <dbReference type="OrthoDB" id="3365211at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021369">
        <property type="entry name" value="DUF2985"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35872">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G07110)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35872:SF2">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G07110)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11204">
        <property type="entry name" value="DUF2985"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="361"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="513"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="551"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="265"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="602"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="73"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="602"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="640"/>
            <end position="651"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM29419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="651" mass="72958" checksum="02F42EA1840AE744" modified="2014-04-16" version="1">MDPIDPVEDPRTSNGNPQEIQPTGQPTESGPVRPGLGSLRSRGDSRMRRPSIRLSRFPSLASLDNANQPASQSGSRPPSSFEPRPIPSPPPNEEDESWLANRRRSNSEPNPGQWPFPPPDGLSRVATPMRMLPLTEEASHQSPAPPSPAAILPGRARSDCDQPDLEQGEVPPAPVRPGRLRRSSQAAMNRFSRNRAATVTGTAPTLSTQQEEQRQDEYGSHVVDVLDVIDPEVSALSTLTNVQNSLFVPNLGSFVNRMPTYTITRPQYSSSDDEPGTATDDNELSDDKLKERPNLEQVHFTSMSSVLPGPKYAVLPGGQVEGWSREDYAELNDHVRHMLHSRRSKFKRAMKGFRQYIKKPLGFLVTLYATLITLFGLAWVLFLIGWINLGARQSYVVNIIDNILVALFAIMGDGLAPFRAVDTYHMSFIAHYTLKSWKLRQKRALPSLKDKNDLPSKPETDADLEFGEAVKEEEHEFSVLSAHQQLRLMHHQNKFAKSHTFYKPHETMTHHAFPLRLLIAIVVILDCHSILQMALGACTWSMEDPHRRPFALTTVILCFSITCNISGGVMIMIGDRRTRKKDVVERLFRQQLTEEAMRKMEKKRIKEERRSLQIERTSTQIERPGAQIGRSSAQIGRSSAHIDRSAPHGGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q5G6</accession>
    <name>W6Q5G6_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S02g001376</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q5G6"/>
    <dbReference type="OMA" id="QSQRFME"/>
    <dbReference type="OrthoDB" id="4509809at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM31226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="253" mass="28698" checksum="CF46FF990BB31BF1" modified="2014-04-16" version="1">MTANFKPTMNPTAEDEVVGDSHAHLKANSKIKSNANDPPVPWSEIFSRHEAFLCSHLDMLSMVKDQIAPEVNGFQTVSSMVNKTVLAMNQLKIARKHIVSKNATLPASSSSSSSNPTQSTDTEANIRKKRRRISRDNDTARPDPTEEERAPKRHRESPSQPITEQEGEFTSTWLGTEDISAEVQRRLKIKEEQRFRKENPKADKRKRDSLVSNDGESQIACKPRKKRLRLENGHKRHGDLVDDADKKKRRKSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q5W1</accession>
    <name>W6Q5W1_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S02g001516</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q5W1"/>
    <dbReference type="STRING" id="1365484.W6Q5W1"/>
    <dbReference type="OMA" id="ERMNVTP"/>
    <dbReference type="OrthoDB" id="66726at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22696">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22696:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="166"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="353"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="381"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="419"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="726"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="742"/>
            <end position="754"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM31366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="957" mass="106367" checksum="AE4DFE0D4AAE51CD" modified="2014-04-16" version="1">MSSGVEPSSIPTSSAALLQHLNTTLSPEPSPLSSLPHQLLTSPLRAFQHAETFAFRTVPRTFARITGIKALGQTIWGGAGSTSGASGTAATHAAEMAANEFADTASQESGYYIAELLGAMKKLGGFFGYLTSLWSFACLVEALILNRITIYASTRRHLRLGWERRAALRLIPILLFVSQILSLLRGIRCQTSPSFSTMRYGSPGKQLVFDYSSDGGALYSISSTLLGWESEERSCAAVRMARGTNPGVPYGSFSLLWPTFMLLCLSHFIETLSCALQGKPVMTETGMSIFEHSIAFAEAESMISKSIGLGLFGLPKQSPLSALSGGSDANSTSVFELLTRSQVLERMNVTPELLLIVLISCCNSATSHILEVFGKQSKYRLFSTAFWGACFMIAMLWGLDGGPPVSLETGVLRFPTVCIVGFIPHIFLLGGIVICLSIYTLALTITAFSLPSDDQPVSLYDRFLMAHENMQGSNQIRSIRINRHEDFYTTLLRIGYVALTAASEAVFLNEGQSVVARRMTWLEEDRLSEIEASRRKSSSYGNWQSQTRSRPIEAMGFSSFDMPEQSAWESGYNREKKIEKPKNGTRAVQSRAELGGVGAVRVSIRLWHVLSFFRAISLLMLRWVAYGLNNVLDRLGINARPMWLKRMVGHRGKKSNTDKTNPSQPLDFWILSENGELELPDDHDFDVEIEMRKRERANRPDWMGSDESRLEDRLYSWWKIGGAWGNQDQTSDYSPPSDDFDTTSVVSMSTNASDSEWEDNLSEDGRRTPTQLDPYADRASPPLQDPLIDMSTLARLLDPRDRESREEARILAAHLKTNPDNPQIMTRSRYQKQVERERSRIIFSSRLQQLNAMNSESEGRKPTPEEEAELLEKLILSRRSETSGISDSHTWESGATGLGPNGPPCVVCQTSPRAIITWPCRCLCICEDCRVSLAMNNFGSCVTCRQEVVGFMRLWVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q5Z2</accession>
    <name>W6Q5Z2_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hemopexin/matrixin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S01g003481</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q5Z2"/>
    <dbReference type="STRING" id="1365484.W6Q5Z2"/>
    <dbReference type="OrthoDB" id="10260248at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.110.10.10">
        <property type="entry name" value="Hemopexin-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052738">
        <property type="entry name" value="ABC-Tungstate_binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036375">
        <property type="entry name" value="Hemopexin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018487">
        <property type="entry name" value="Hemopexin-like_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024370">
        <property type="entry name" value="PBP_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37945">
        <property type="entry name" value="EXTRACELLULAR TUNGSTATE BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37945:SF1">
        <property type="entry name" value="EXTRACELLULAR TUNGSTATE BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12849">
        <property type="entry name" value="PBP_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00120">
        <property type="entry name" value="HX"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50923">
        <property type="entry name" value="Hemopexin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51642">
        <property type="entry name" value="HEMOPEXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PBP" evidence="2">
        <location>
            <begin position="16"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="repeat" description="Hemopexin" evidence="1">
        <location>
            <begin position="294"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM29669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="515" mass="57909" checksum="2AF54EBFD7BB43B2" modified="2014-04-16" version="1">MAERIAPSAVYSTRKEKVLLRIATGGAGQSGLLEALAISFVQYCVDNKKAEPFLIEWYKSDTTSSIENLLKETADIAITSNALDDNVIDRVVYAWRDHWMLVGPKRNPANLPEDRQTSIFSLLTKLLSRMEESKNSAKPIKFLSRYDKSAGNIIESLLWATIGQVPWANPPTSWYHMFPGFPFQAIREAAGRGEYTVIDKETWLAIEDETRKQLTIFAEGNNDENDLLLNPAHILVGKNAKNKATANDFADWIVRDDGGQQVIRSFTKSGEVLYSTIPVGVDPLDRVKGLLGFSGSTKAVFPLTWSEDEIYFWKDHQYARVNVMTDTIDPSPPRDIWSWWPGLKKFGFAPINAAFVATDNEVDTYFFCGSRCVRLNAKTGHPSGGQLTPFRFQEKWPGLKDVGFDLVDAALPFSFKGSEYQHVVCFFRKDRYALIDVNRNILLESGNIALRFNALAQANFKTIDTVVFKPRRSKLQAYFFSGKQYVLVDLAGDSIARGPLDVAAEWKSLKTAGFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q5Z7</accession>
    <name>W6Q5Z7_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type DNA-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PROQFM164_S02g002279</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q5Z7"/>
    <dbReference type="STRING" id="1365484.W6Q5Z7"/>
    <dbReference type="OMA" id="MMIAKMI"/>
    <dbReference type="OrthoDB" id="4525710at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF2">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="10"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="52"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="96"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM32128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="485" mass="54724" checksum="2FF7AA7EEF7A7FC0" modified="2014-04-16" version="1">MVSPKDQSSVCQACRIRHISCDRATPSCRRCRTAGRPCTRRFNVRFSTRRNWVPPVTPLSPPDSQSRTLPSPRLDQDARPPLEPSQQLTRSDRSETPQWSSQPQTPVESLPADNVIHQDRFHSISPGTSPQAGEQRIGNELSTSSPLLLTSEDAYLMQYFGESIGRPWFDHTDSDFTLEVLRIAPSCPVLCYSILAVSSFYHCKATGQNDGRADLFHRKAIDILLALMHDPVRLSDGAGLASVVILRLYEESKARQDGQDAESHLLAGHVFAATIASDKQQPVTKLAKSAFWVHQRQDVFHSISQQKPTRTSLDVTHLWEPGDSDDIYTWTKRSQKLAGETADFCFGNDEAQSRKQHFEDLQRMLTQWSELSWPAFQPVFFADSDLKTGRILPEIRFALNACLTGYVHFRLSQLLLAMYNPSRLTLGPQAIDHHKEMESEVQDHVRVLCGAARFNTCPIGKVIACLAITLDGFMTLRREWSCWSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q6R6</accession>
    <name>W6Q6R6_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S02g000098</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM29949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q6R6"/>
    <dbReference type="STRING" id="1365484.W6Q6R6"/>
    <dbReference type="OrthoDB" id="3525185at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM29949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="63" mass="7057" checksum="A24EB7E8D2E8F098" modified="2014-04-16" version="1">MALVTAEEAQQWATIPRASMDEALMAGSVSKALDRQYRNGFCDLVDAIFPNIYYSYSTHVELP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q6U5</accession>
    <name>W6Q6U5_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Arylsulfatase</fullName>
            <shortName evidence="5">AS</shortName>
            <ecNumber evidence="5">3.1.6.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Aryl-sulfate sulphohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PROQFM164_S02g000128</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>an aryl sulfate + H2O = a phenol + sulfate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17261"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16189"/>
            <dbReference type="ChEBI" id="CHEBI:33853"/>
            <dbReference type="ChEBI" id="CHEBI:140317"/>
            <dbReference type="EC" id="3.1.6.1"/>
        </reaction>
    </comment>
    <comment type="PTM">
        <text evidence="6">The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the sulfatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.6.1" evidence="5"/>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM29979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q6U5"/>
    <dbReference type="STRING" id="1365484.W6Q6U5"/>
    <dbReference type="OMA" id="GHNENWL"/>
    <dbReference type="OrthoDB" id="96314at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004065">
        <property type="term" value="F:arylsulfatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005539">
        <property type="term" value="F:glycosaminoglycan binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008449">
        <property type="term" value="F:N-acetylglucosamine-6-sulfatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018958">
        <property type="term" value="P:phenol-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16147">
        <property type="entry name" value="G6S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.720.10:FF:000051">
        <property type="entry name" value="Arylsulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012083">
        <property type="entry name" value="Arylsulfatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43108">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-6-SULFATASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43108:SF8">
        <property type="entry name" value="SD21168P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000972">
        <property type="entry name" value="Arylsulf_plant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00523">
        <property type="entry name" value="SULFATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004879625" description="Arylsulfatase" evidence="7">
        <location>
            <begin position="19"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase N-terminal" evidence="8">
        <location>
            <begin position="43"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="modified residue" description="3-oxoalanine (Cys)" evidence="6">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR000972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000972-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM29979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="590" mass="65895" checksum="EEAD192D80E315AF" modified="2014-04-16" version="1">MKLITAIAGLVAVEGVAALNFQSNLQSVLQSVLKPNEGQLRKPNILFVITDDQDLQLDSISYTPLISKHIRDQGTFFRNHFVTTALCCPSRVSLWTGRQAHNTNVTDVHPPYGGYPKFVERGFNDDFLPLWLQGAGYDTYYTGKMFNAHTVYNYDSPHINGFNGSDFLLDPYTYSYLNSTYQRNHEPPVSHEGEHTIDVITGKALGFLDDALAGERPFFLAVSPVAPHSNVDPGDITSGNFYMSAPVPLERHQHLFQGVTVPRTANFNPDQPSGVSWVHDLPLQNQSVVDYNDHFYRSRLRALQGVDELVDGLVTRLEQSGQLDNTYIIYTSDNGFHIGQHRLPPGKTCGFEEDIRVPLFIRGPGVAKGYVQDAVTTHVDLAPTLFHLAGIPPRDDFDGTAIPMTPEFEGERHEHVTVEYWGSAVVEGIYSGIGPGGSTLIPNNTYKSVRLHGDGYSLYYSVWCNNEHELYDMSTDPYQLNNLYPTSSQEDLNEPRILGRNLTQAINRLDALLMVLKSCQGVTCIHPWDVLQPVDPVSTLQDALNEEYDGFYSAQPHVSFDWCDAGYIVEAEGPQVPLTSRHGVSWDVWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q752</accession>
    <name>W6Q752_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Scytalone dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S02g002709</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the scytalone dehydratase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q752"/>
    <dbReference type="STRING" id="1365484.W6Q752"/>
    <dbReference type="OMA" id="WQVRARH"/>
    <dbReference type="OrthoDB" id="5281072at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049884">
        <property type="entry name" value="Scytalone_dh"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02982">
        <property type="entry name" value="Scytalone_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Scytalone dehydratase-like" evidence="3">
        <location>
            <begin position="7"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM32558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="173" mass="19783" checksum="5EF32EB293BD178D" modified="2014-04-16" version="1">MDYTIADERKFRELAYKWAMAWDKKDKDAFISIATSRIIADYTDYPAVGVVKHCPPDDFVNFAFREDRLGDPRCKLSPRGNSLFLLMYLEVQTQHFLGSVAFTRVNDTEAIGNWQVRARHVRKFPDGKTAEWDSSAYLELCYVLTGGEWKIGGLRPHTVLATTGSHQEVIGQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q7U1</accession>
    <name>W6Q7U1_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S02g002232</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q7U1"/>
    <dbReference type="OMA" id="GWILEMG"/>
    <dbReference type="OrthoDB" id="5389296at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="431"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="225"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM32081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="472" mass="51016" checksum="5F80F42E3B805F6F" modified="2014-04-16" version="1">MPFPATPSPFRLARRNPSTRRSGPQFASTPRFLLSQSVAQKEDDDLDLIDDDGPSSTRKVASNLPVTQTAPGSRQQRDVIEDSDDAAGIGDVQTGGRDADELPDDAINSTPPEEAETPGILDAEFDALFSPVRDGNKRRRVEGVAPSHRRNLTHIDPILSSPPESVDPPADPIALSDKSRQSTTAWDMGMERNPAPSACLFAQAASTPSNMKTPFRSRPRFMLSSAARPPSSQSAPRFKLDEPGISPSERRKPVFVLPRSPSPNPDAEDIPAPFSPSSRTLHRRGRNRAGVSNYIPGGMAAEARGWILEMGTKRDQLPKPPLGQASDSPEKPNAYLLTARVIHVSQSSMSGCGSLAFLQAELLTGNHIQGRNPDSVLNIMIMGTSRSKSVVRQNPSRSDAITTPQLRKGDLVGIHKGLNWSLELGNDSYERRSPGQVSGYVSERGPSDNGGSLETKEGWLIAMEWDLIGAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q855</accession>
    <name>W6Q855_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uracil-regulated protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">urg1</name>
        <name evidence="8" type="ORF">PROQFM164_S02g002322</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GTP cyclohydrolase II family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q855"/>
    <dbReference type="STRING" id="1365484.W6Q855"/>
    <dbReference type="OMA" id="FQQLMPD"/>
    <dbReference type="OrthoDB" id="57939at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003935">
        <property type="term" value="F:GTP cyclohydrolase II activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00641">
        <property type="entry name" value="GTP_cyclohydro2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10990">
        <property type="entry name" value="GTP cyclohydrolase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022163">
        <property type="entry name" value="GTP_CH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032677">
        <property type="entry name" value="GTP_cyclohydro_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000926">
        <property type="entry name" value="RibA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036144">
        <property type="entry name" value="RibA-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005536">
        <property type="entry name" value="PRK07198.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47259">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47259:SF2">
        <property type="entry name" value="URACIL-REGULATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12471">
        <property type="entry name" value="GTP_CH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00925">
        <property type="entry name" value="GTP_cyclohydro2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142695">
        <property type="entry name" value="RibA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GTP cyclohydrolase N-terminal" evidence="7">
        <location>
            <begin position="39"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="GTP cyclohydrolase II" evidence="6">
        <location>
            <begin position="272"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="17"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM32171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="456" mass="50318" checksum="518E54E1917EFC37" modified="2014-04-16" version="1">MLKTESVTNILPVQMEPSTAPAAPAASAAPADPNPRYSNHIILTTYPGQSGIEPVPLEWGAPDAKSRGPVVVSRSGNLVKRRNAIGAHGGSYSVYNALAIAAGDLDADFRPDFRNSQPTFNFPPQPAWADKKKIVSMDPYGHDIVNQFKEELEAGWDIRPTMAVTRANMKLAEIADDVKNGLLEVDGSVLVDSSGEVRVTKVAAEPVWYLPGVAERFGVDEGTLRRTLFEHTGGSYPELITRPDLKTFLPPIGGLTVYIFGPPERIADPNVKLALRVHDECNGSDVFQSDICTCRPYLAFGIREAIREAQNGGSGVVIYFRKEGRALGEVIKYLVYNARKRGGDTADKYFTRTENIAGVRDMRFQALMPDILHWLGITKIDRMLSMSNMKYDAIVNSGINIIERIPIPDEMIPSDSRVEIDAKIQSGYFTTGKQLTDEELAQVRGRGWEKWEDISH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q924</accession>
    <name>W6Q924_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RNase P subunit p30</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PROQFM164_S02g002652</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic/archaeal RNase P protein component 3 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q924"/>
    <dbReference type="STRING" id="1365484.W6Q924"/>
    <dbReference type="OMA" id="CYGPGIT"/>
    <dbReference type="OrthoDB" id="17948at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005655">
        <property type="term" value="C:nucleolar ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000053">
        <property type="entry name" value="Ribonuclease P complex subunit Pop2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002738">
        <property type="entry name" value="RNase_P_p30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13031:SF0">
        <property type="entry name" value="RIBONUCLEASE P PROTEIN SUBUNIT P30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13031">
        <property type="entry name" value="RIBONUCLEASE P SUBUNIT P30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01876">
        <property type="entry name" value="RNase_P_p30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="PHP domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="236"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="297"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDM32501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="307" mass="33556" checksum="EE9A7F37FE76F7BD" modified="2014-04-16" version="1">MFYDLNVPYSPDDPEVPHTLNFLAELGYTTVALSQTINGKLPPSLAPPPLPTNAPKSLQLLTRLNLTLADPAQNQRLNALSQAYDIVALRPTNEKSLLNACTNLECDVISVDLSVRLPYHFKFKMLSAAISRGVRIEICYGPGITGSGLDARRNLIGNATSLIRATRGRGIIVSSEARRALGLRAPWDVINLACVWGLSQERGKEAVCEESRKVTALAKLKRTSWRGIVDIVNGGEKVKPEGFTPKQKNNPKAKEPVQPENGVDNLKRKASISSEPVGEDADKPLSKREIKRRAKKAKFDAKGENAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q986</accession>
    <name>W6Q986_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Autophagy-related protein 18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">atg18</name>
        <name evidence="17" type="ORF">PROQFM164_S02g000899</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Necessary for proper vacuole morphology. Plays an important role in osmotically-induced vacuole fragmentation. Required for cytoplasm to vacuole transport (Cvt) vesicle formation, pexophagy and starvation-induced autophagy. Involved in correct ATG9 trafficking to the pre-autophagosomal structure. Might also be involved in premeiotic DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Component of the PI(3,5)P2 regulatory complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Preautophagosomal structure membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the WD repeat PROPPIN family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q986"/>
    <dbReference type="STRING" id="1365484.W6Q986"/>
    <dbReference type="OMA" id="NIAILEM"/>
    <dbReference type="OrthoDB" id="1667587at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000965">
        <property type="entry name" value="Autophagy-like protein 18 Atg18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048720">
        <property type="entry name" value="PROPPIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11227">
        <property type="entry name" value="WD-REPEAT PROTEIN INTERACTING WITH PHOSPHOINOSIDES WIPI -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21032">
        <property type="entry name" value="PROPPIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0072">Autophagy</keyword>
    <keyword evidence="8" id="KW-0967">Endosome</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="5" id="KW-0926">Vacuole</keyword>
    <keyword evidence="6" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="262"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="263"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00037510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00038649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00039247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CDM30749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="427" mass="46041" checksum="B54E710C0FE337A8" modified="2014-04-16" version="1">MAMNFVTFNQDYSYLAVATSKGFQIFTTEPFAKSYEAKEGNIAVIEMLFSTSLVALILSPRRLQIQNTKRQCTICELTFPTTVLAVKLNRKRLVIVLEDQIYLYDIQTMKLLSTIDTSPNPNAICALAPSSENCYMAYPLPQKAPAAANTPAHAPPGTTHVSPTTGDVLIFDAVKLEAINVIEAHRSPLALIALNSDGTLLATASDKGTIIRIFSVPDGHKLYQFRRGSMPSRIYSMSFNTASTLLCVSSSTDTVHIFKLAQQGPSSDGSSLHSPPGRDHGSPPNTYGYSPEEDETGGDAGSDSSSRRHNGTLMGMLRRTSQNVGGAVAARMGGYLPKGVSEMWEPARDFAWIKLPRSNPGPGGNTGPGPLRSVVAMSSNTPQVMVVTSDGNFYVFNIDLSKGGEGTLTKQYSVVDSTDRLGYTAEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q9F7</accession>
    <name>W6Q9F7_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S02g000979</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q9F7"/>
    <dbReference type="OMA" id="WCEDVEN"/>
    <dbReference type="OrthoDB" id="5421702at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="434"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM30829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="583" mass="65330" checksum="A5EEA3CC5DB83641" modified="2014-04-16" version="1">MGEFIMADPYANLLVCEPFDWWEDVENDIAMKTQAIPTTPTVPITATELVDKYSPLLTRGQFNWLEDNEDDIAMKTKALVIPTPDTENMATASIGPAIDRNDDKYAHLLEHEQFDRLEDVENYIAMGIDLATIPSSPATTSKLDDKYSKPPVHQDCLEDDENDTAMDTKYLAIDNEPPATTNGPIIAVALDDSYAHLLHRETSDSVDNAEATLAMDHQPEMAVTMSSNEIIDSPQPVELNQSLDIPNSASTTEPVQNLQLASPQPELDEFNYRAEICNEDNTIHHWNWLGWPVYTRTATPPGVSLAFMQAIPKAPRGRDKLRVNSIMKCAIEYIDPVILKVDRGDEGILQMYGSAMIEACEGLTYTHYSLHGNWMSDDFSMRRRIVPDAGESELERFAIGRFAVANGLLEGGPFISRYEWLDWRDQLVAASKEPVRSPRKRTWKPTPSKLKIESTSSKELSPPSRPLTFSSVPLEIVGNTQKARITTKTIHSSVVFPIGIMRTIMKKTWPVPTTVPNTVFSLPFGSMGIFIEKPLVTFSNIPREMFVFPLGIMWGFMKRALHLIRAAFTPRVLLPETLSSLSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W6QA62</accession>
    <name>W6QA62_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Major facilitator superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PROQFM164_S03g000282</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QA62"/>
    <dbReference type="OMA" id="TFFCGVQ"/>
    <dbReference type="OrthoDB" id="410267at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17352">
        <property type="entry name" value="MFS_MCT_SLC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF177">
        <property type="entry name" value="RIBOFLAVIN TRANSPORTER MCH5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="95"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="165"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="222"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="254"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="300"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="334"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="365"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="390"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="425"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="455"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="4">
        <location>
            <begin position="94"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDM33558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="490" mass="53200" checksum="A18CDC6F364FBBB8" modified="2014-04-16" version="1">MSTNVGSAGGKTGDHEFDILNTNQSATSFDQKTTAHMVNEKFDTEAAPEQEPSLDDVYRTASTVAPSQRSARRDPISRATTDAEGNIYPEGGLEAWLVVLGSFLGLFGSLGLVNTIATFQAYIQTHQLKEYSSGTNGWIFGMFAFLTFFCGVQVGPIFDARGPRILVFVGSVFEMAMIILLGFCTEYWHFMMVIGVLGGVGASLIFTPAVSAIGHYFYEKRGVATGVAATGGSVGGIVFPLILEALFPKIGWAWATRVVALICLVVLSIANLLIRSRLPQKPFSKENVLPDFRIFRDPRFVLTTASVFFIEWGLFVPISYISSYALDHGFSSKFSYQIIAVLNAGSFFGRWLPGFFADFLGRFNTLIATVALCVLCNACLWLPAGDSMPLLIVYAVIFGFSSGSNISLTPVCVGQLCKTEHYGRYYATAYTIVSFGTLTGIPIAGEILARCDGSYWGLITFTVCCYAAGLACCTAVKVIEVGWRHPLAIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W6QA79</accession>
    <name>W6QA79_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF6987 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PROQFM164_S02g003067</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QA79"/>
    <dbReference type="STRING" id="1365484.W6QA79"/>
    <dbReference type="OMA" id="CDAEGQF"/>
    <dbReference type="OrthoDB" id="3937590at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.20">
        <property type="entry name" value="Apolipoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022124">
        <property type="entry name" value="DUF3659"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054256">
        <property type="entry name" value="DUF6987"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39461">
        <property type="entry name" value="LEA DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_8G04920)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39461:SF1">
        <property type="entry name" value="LEA DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_8G04920)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12396">
        <property type="entry name" value="DUF3659"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22485">
        <property type="entry name" value="DUF6987"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1163"/>
            <end position="1185"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6987" evidence="4">
        <location>
            <begin position="1016"/>
            <end position="1213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="316"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="640"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="781"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1001"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="214"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="26"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="61"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="92"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="119"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="316"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="333"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="380"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="403"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="456"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="471"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="487"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="647"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="790"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1001"/>
            <end position="1016"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDM32916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="1225" mass="128171" checksum="4284D611EBF54610" modified="2014-04-16" version="1">MSSPAVNKAPPKLGSKAGTPAKARKASGSSAASKPSTVTASPKVTKKTATPRKLSQKAPEPIEDDVDEQSIPETPSPKSKRRTEQRRPVSPPDDAASQAPSASGSAAPLSRGGSSLAGKAKDVAGKTKETAEKSAESVTSGAKDATKTATDNLPVPFDLSALKGLDVAEGGNILGQDGNPIGKVVEGDPEDLVGQTVGDDGEIVDEEGDLIGRVDILHEVADKAKNAADDAQENVGEADLENVVTDIAQLEGLPVSDGGVIKNAAGQIVGRIVEGDPEDLIGYTLNDDGEIVDEDGDPIGRVDLVPVEDQKKAIEEATGDATDKVDGAKGDVEDQYEDAQDDIPADQAKSAVDGAADQVEDGVSDAEGNVDKAKSTAEDAAPDAEDATDAVDGAVDDATDTAEDGKINLEDNVDDAKDTAEDKVEGAEDTAEDAKDAAEETAEGVTDAPDDKVEGAEDAAEDAAEDATDALDDKVEGAEDAAKDAAEDAAEDAAEDAQDTAEDAAEDVEENIPGLETLEGKVCNKLGYIIDEATGKPVGQVTEGDPKKLAKLGSTLDDKGQFWDNRGNVIGQAKALPIEEHDGDEGPFSGLEGLVVGEDGFVVDENSTRVGRLIEGDAKKLSGRGVDEDGEILDRKGNVLGRAERLEPEEEPEEEEEAGPDFSAVNGLTCNKAGYVIGPDGYPIARVVEGNPKELAGKKIDEGEIYDGKKVIGRVELIPEDEIDSKPEGIFAGMDSLFVTKDGFVEDDEGSIVGKLVEGEAKKLRGRAVDEDGEITDKYGNVKGRAEPYEPPEEEPAPEEDLSILDGKVVNKSGNVVDPTTGAVVGRILEGDKRLAGCKVDGKGQIWGDNGKVVGRAGLIPGTEQDKAEGPFFGFDNAIVGKDGVVQDGDKIIGRLIEGDAKRLLGRKVDEEGDVLDKNGNSIGKAERWEPEEKKRDINPMSGRKVNKEGEVRDEDGNLIGKLTAGNLATLIGKSIDDNGYVIDNDGNKIGECTLLENIPEPEEEVEEGPTAEEQEAAAKAESDRQLAEKMISILSQTLDRVKPVCKQITEACDKADHTKKEDLDEEKLVQTVKPLLEEGGRILQECNGAIRALDPDGRIAATAKARAASRDATPEEYQLADLIKELTETVVKTIDNGKKRIADMPHAKKALNPLWGLLSEPLFQIIAAVGLLLTGVLGLVGRLLDGLGLGGLLNGLLGSLGLDKIINGLGLGGLTDALGLGGNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W6QB47</accession>
    <name>W6QB47_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S03</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S03g000632</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QB47"/>
    <dbReference type="STRING" id="1365484.W6QB47"/>
    <dbReference type="OMA" id="SNDQHRT"/>
    <dbReference type="OrthoDB" id="5359669at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="349"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="53"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM33908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="369" mass="39380" checksum="968CE421DB4B21BF" modified="2014-04-16" version="1">MSPMILNRLSDGPVTVLSPPREHAFAQFSQSSFLDSPGSFNSYPTNTSPVFTNNSSTPSVPSSFNLSSAPAVPKPSRKRSRDEATFEDAVAPSAPLAHQAVPATKVRPIYGEGMALLNPQTGLAISAESQTGTWYEQESEAQQAAAAPVPSRSNALLSDAAEVSRKSQRLDKSAPGLDDIALSSIRQRLDDPRSNDQHRTLNAGPAPPVEPLVDDATRLLGIGWQRVNTDGDMAPAVRGWTKYIDNQYSAHLHGSQMLMKSRALNAYLVAATPTSGSLPAFYLFTEDLTQGQLVASSWEGCLQNLRSSPIIFEGSTPLGATDRPRAQPVSFNSMDTGLPLLQQALSNNPQASSLDELSGGAEMGMEIDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W6QC50</accession>
    <name>W6QC50_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 3 subunit K</fullName>
            <shortName evidence="4">eIF3k</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">eIF-3 p25</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PROQFM164_S03g000759</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the eIF-3 subunit K family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QC50"/>
    <dbReference type="STRING" id="1365484.W6QC50"/>
    <dbReference type="OMA" id="GDDLCAD"/>
    <dbReference type="OrthoDB" id="337745at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006446">
        <property type="term" value="P:regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000389">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.250:FF:000003">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.250">
        <property type="entry name" value="ARM repeat, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03010">
        <property type="entry name" value="eIF3k"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033464">
        <property type="entry name" value="CSN8_PSD8_EIF3K"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009374">
        <property type="entry name" value="eIF3k"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016020">
        <property type="entry name" value="Transl_init_fac_sub12_N_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13022">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13022:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10075">
        <property type="entry name" value="CSN8_PSD8_EIF3K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4 6" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="5">
        <location>
            <begin position="45"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDM34035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="245" mass="27498" checksum="63B966193AA183AF" modified="2014-04-16" version="1">MVAFDKCETRPAHIEAILNGLDRYNPETTTVFQDYVSQQCEDRSFDCYANLALLKLFQFNPHLIQPDTVTNILVKALTVFPSPAFSLCLALLPTNTQPFPTTNEAHSASQTSDFVESVQKLTRLSSLLESAQYAQFWSTLNSDDLYADLTADVAGFEELVRIRIAVEVGNTFRSITAENLESWLDVRSRDALDKFVVDVCGWKVDGAVIRVPTNKENEARSEVKSEHVGIEQFGRVIRRGFELPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>W6QC76</accession>
    <name>W6QC76_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PROQFM164_S03g000799</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QC76"/>
    <dbReference type="STRING" id="1365484.W6QC76"/>
    <dbReference type="OMA" id="ECADQLD"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11059">
        <property type="entry name" value="CYP_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF164">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6 7" id="KW-0408">Iron</keyword>
    <keyword evidence="3 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004879523" evidence="8">
        <location>
            <begin position="24"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="451"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM34075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="514" mass="58024" checksum="3FB4DF02170F5EA6" modified="2014-04-16" version="1">MTWILIAAFIVAFLVYQLSVSTSFSPLARIPGPKTFALTKFKLAYEDYKGTRTRKINALHHQYGPVVRIGPSEVTFNSTSAVRAIYGAGSGFERTGFYHMFEVYGRKNMFSFATTKQHGERKKLFAHAYAKSAMLKGQNAQMVEQKVKLYMDLLERDGGKSEIFSTLHYFSLDTITEFLYGSFGKTACLEGQRQDCALIGDIIDIARRKLSWYAVHFPHFTEWLYSRTGVTGCIAKRFYPMQMPTTYSGIRLHALKATQKYASASASAKASTSALISRLWSHHHSQKPNGLDDLDIASECADHLLAGIDTTSDTLMFLIWALSRPENRQFQDKLIEEVCNIPEDSLDSNAIPKVENSDKLSYLDAVIKETLRLYAPLPGSEPRSLPTATIIDGYTIPPGTVVSISPYALHRNPDVFKNPMKFNPDRWLDPCANLAEMKKWFWAFSSGGRMCIGMHLAMAEMTTLVAAIYRKYRTTPMGDFDTVSPGITGRYEVFYDDTCSRMREHECQIEFTPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W6QCH0</accession>
    <name>W6QCH0_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S03</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S03g000904</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QCH0"/>
    <dbReference type="STRING" id="1365484.W6QCH0"/>
    <dbReference type="OMA" id="KCCGDAK"/>
    <dbReference type="OrthoDB" id="3520229at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM34180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="155" mass="15497" checksum="E4CF94F04CB02507" modified="2014-04-16" version="1">MSTTSSTTSSVSTTSTACGGSVWQIPTTDSACAAVISGNMTDVMDECCKDAKVSKYDNDCGIYCLAQGQNVDKLQSCLTSKSGNYHDVFCNAALNATATATATGSKSTSSGTGSSTHSSAASTSTNAAISNQPISKSGVGMIALLFGSALMAVIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W6QCL7</accession>
    <name>W6QCL7_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S01g001161</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QCL7"/>
    <dbReference type="OrthoDB" id="103819at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM27352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="57" mass="6332" checksum="BF4826E514F633C3" modified="2014-04-16" version="1">MSLSQGLSNERNAIQISLSPRLGSPLSDLVRNPFAITWADDLVFNQFGFTGDEYARD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W6QD28</accession>
    <name>W6QD28_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S03g001089</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QD28"/>
    <dbReference type="OMA" id="RWCISIP"/>
    <dbReference type="OrthoDB" id="4278107at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM34365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="143" mass="16821" checksum="5B3B72A7C011694C" modified="2014-04-16" version="1">MSYYITIHHGPGVDESPENMWVNITFTTKDHFYLRTDGALICLIIERIREMKFEFTPEPMDRQFRWCISLPVSKAHDTEDGVIADALGLAEWYRVQILNGNATINRKLLFDRKPFNEGKECCRDNVCDRILHPEWWVDTCKDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W6QDV2</accession>
    <name>W6QDV2_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Endoplasmic reticulum transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PROQFM164_S03g001405</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">May play a role in anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Endoplasmic reticulum membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the BCAP29/BCAP31 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QDV2"/>
    <dbReference type="STRING" id="1365484.W6QDV2"/>
    <dbReference type="OMA" id="FIDCINR"/>
    <dbReference type="OrthoDB" id="435607at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070973">
        <property type="term" value="P:protein localization to endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008417">
        <property type="entry name" value="BAP29/BAP31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040463">
        <property type="entry name" value="BAP29/BAP31_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041672">
        <property type="entry name" value="Bap31/Bap29_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12701">
        <property type="entry name" value="BCR-ASSOCIATED PROTEIN, BAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12701:SF20">
        <property type="entry name" value="ENDOPLASMIC RETICULUM TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05529">
        <property type="entry name" value="Bap31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18035">
        <property type="entry name" value="Bap31_Bap29_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 11" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="47"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="BAP29/BAP31 transmembrane" evidence="13">
        <location>
            <begin position="1"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="Bap31/Bap29 cytoplasmic coiled-coil" evidence="14">
        <location>
            <begin position="163"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="165"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF05529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF18035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CDM34680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="215" mass="24475" checksum="56FF18BA3F2A93A7" modified="2014-04-16" version="1">MTLYYSLVFLLLVFEMGVFLALVIPLPHVVKRKLFAFISESPIIAKLQYGLKITFIFILILFIDSVNRVYRVQQELSAFAKDGPGMGAAHLGTDRMEVQARKFYSQRNMYLCGFTLFLSLILNRTYTMILETLRLEDRVRLIEGDKKAGGKDSARIAEAGSVGEIGRLKEIIATKNRDIETLKKQCEGLTREYHSLGDQISNEKGDKNEKDKKDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W6QE14</accession>
    <name>W6QE14_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S02g002585</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QE14"/>
    <dbReference type="STRING" id="1365484.W6QE14"/>
    <dbReference type="OrthoDB" id="4358152at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM32434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="144" mass="16467" checksum="95F8860BCAA7C765" modified="2014-04-16" version="1">MGDQSVLIYWRALVFMGKLADPWIITLSVLSLVIIYPYGNLKAVNAYFFGASASAESGLNTVDVKFLETYQQIYIYLILILGNLGFINMICYIDQASFLIWQRDSFCFRLFVLVDSKGLFNSDCFRLLYIKDLALGFSSTPHLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W6QE33</accession>
    <name>W6QE33_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 16">Diacylglycerol O-acyltransferase</fullName>
            <ecNumber evidence="5 16">2.3.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">DGAT2A</name>
        <name evidence="18" type="ORF">PROQFM164_S02g002610</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 16">
            <text>an acyl-CoA + a 1,2-diacyl-sn-glycerol = a triacyl-sn-glycerol + CoA</text>
            <dbReference type="Rhea" id="RHEA:10868"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:64615"/>
            <dbReference type="EC" id="2.3.1.20"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 16">Glycerolipid metabolism; triacylglycerol biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 16">Endoplasmic reticulum membrane</location>
            <topology evidence="1 16">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 16">Belongs to the diacylglycerol acyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.20" evidence="5 16"/>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QE33"/>
    <dbReference type="STRING" id="1365484.W6QE33"/>
    <dbReference type="OMA" id="FWFTCAN"/>
    <dbReference type="OrthoDB" id="264532at2759"/>
    <dbReference type="UniPathway" id="UPA00282"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004144">
        <property type="term" value="F:diacylglycerol O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019432">
        <property type="term" value="P:triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07987">
        <property type="entry name" value="LPLAT_MGAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007130">
        <property type="entry name" value="DAGAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12317:SF0">
        <property type="entry name" value="ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12317">
        <property type="entry name" value="DIACYLGLYCEROL O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03982">
        <property type="entry name" value="DAGAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 16 18" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="10 16" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0319">Glycerol metabolism</keyword>
    <keyword evidence="6 16" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12 16" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 18" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="41"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="73"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="7"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU367023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CDM32459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="365" mass="41064" checksum="9F0FAA3952A388D3" modified="2014-04-16" version="1">MNGETLSAGQASASTSQSSRGRKHIHWAPLNIGLERRLQTFVVLCHTLTIAIFLTIFFFTCAIPLFWPLLVPYLVYISLFSTAATSGNLKGRSPFMRSLPIWKLYASYFPARLHREESLPSTKKYIFGYHPHGIISHGAFAAFGTEALGFSKLFPGITNTLLTLDANFRIPFYREYALAMGLASVSRESCENILTKGGADGEGMGRAITIVVGGARESLNAQPNSLRLVLKRRKGFVKLAIRTGADLVPVLAFGENNLYDQVDSDQHPIIHKLQMLVKQTLGFTIPLFHARGVFNYDVGLMPYRTPLNIVVGRPIPVMQQQNRDKINDLYIDELHSRYVKELERLWDQWKDVYAKDREGELEIIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>W6QEI6</accession>
    <name>W6QEI6_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Ribosome biogenesis protein BMS1/TSR1, C-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PROQFM164_S03g001165</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the TRAFAC class translation factor GTPase superfamily. Bms1-like GTPase family. BMS1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QEI6"/>
    <dbReference type="STRING" id="1365484.W6QEI6"/>
    <dbReference type="OMA" id="KLHVPMV"/>
    <dbReference type="OrthoDB" id="10260897at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
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        <property type="entry name" value="P-loop_NTPase"/>
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    </dbReference>
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        <property type="entry name" value="RIBIOP_C"/>
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    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
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            <begin position="61"/>
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        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="1185" mass="134634" checksum="0AFD8FEC25C0C481" modified="2014-04-16" version="1">MEQQANRAHRPAKEKKKFEGANPKAFVTSRPGKLNKQAARSHDVREKRLHVPLVDRMPEEAPPVVVAIVGPPGVGKTTLLKSLIRRYTKQTLSSPQGPLTVVTTKRKRLTFIECPSDSLAAAIDVSKIADIVLLMIDGNFGFEMETMEFLNALSTAGMPGNVFGILTHLDQFKKHSTLKDAKKRLKHRFWSELYAGAKLFYLSGVINGRYPDREVHNLSRFLSVMKNPRPLVWRNSHPYALADRFLDITPPTQIEENPKCDRTVALYGYLRGTNFPSHGARVHVPGVGDLTVANIEGLPDPCPTPFMNQQIAKATGKSNRRKLGEHQKLLFAPMSDVGGVLVDKDAVYIDIKTNTFDRDSDEDEEDEERRGLGEHLVVGLQGERKMLGEADQGVRLFRGGEALDKADDDETGRKDRRRARVAVPDQDDIDIPEGSDSEEEADEDMDENDVTDDEGELDMSAPADFEARFKAKQTGNAGGEEEDMAFADSDSDLGSISSVSDQEVESGDEDEDEDEDEDEDEDDEEGNVRWKENMLANAKSLHGKRPPFRVTDLSRMMYDESITPLDVVKTWRGEDSDDEEEDEEDKTADDEGETFFKKTNNEKEDQADFRAVPEYDYDELERKWRDEELLESIKLRFITGKLSGGASDDEDGDMDEDDEDEDEGDGDYEDLESGEVFNGIKEDGDEDEEEEGDEPGKAADLEAERERNAKKKEELKLRFEEEDREGFGKVQDGTHDGIDGEFGEDDWYDLQKAKLQKQADINRAEFDTLDPASRARAEGYKAGTYARIVLENVPYEFVSKFNPRFPVIVGGLSPTEDRFGYVQIRIKKHRWHKKILKSNDPLIFSLGWRRFQTMPIYSTSDSRTRNRMLKYTPEHMHCFATFYGPLVAPNTGFCCVNSFSNKNPGFRIAATGVVQSVDEHTEIVKKLKLTGHPYKIFKNTAFIKDMFTSALEIAKFEGASIKTVSGIRGQIKRALSKPDGCYRATFEDKILMSDIVFLRAWYPIKPHRYYNPVTNLLDQVDGEKGDNGWQGMRLTGEVRHSQGIPTPQIKDSAYKPIERQARHFNPLRVPRQLAAELPFKSQITKMRGHKEPTYMQKRAVVLGGEEKKARDLMQKLTTLRNEKQAKRSIKQEERRKVYRAKVADGLEKKAEREKRERNDYWRKEGKKRKNPDEDSGGRGRGKKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W6QEJ8</accession>
    <name>W6QEJ8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Protein get1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">get1</name>
        <name evidence="9" type="synonym">GET1</name>
        <name evidence="10" type="ORF">PROQFM164_S01g001823</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the WRB/GET1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="C:GET complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:protein-membrane adaptor activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071816">
        <property type="term" value="P:tail-anchored membrane protein insertion into ER membrane"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Protein GET1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Get1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Get1"/>
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        <property type="entry name" value="Get1_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029012">
        <property type="entry name" value="Helix_hairpin_bin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42650:SF1">
        <property type="entry name" value="GUIDED ENTRY OF TAIL-ANCHORED PROTEINS FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42650">
        <property type="entry name" value="TAIL-ANCHORED PROTEIN INSERTION RECEPTOR WRB"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CHD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="topological domain" description="Lumenal" evidence="9">
        <location>
            <begin position="1"/>
            <end position="4"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="9">
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            <end position="204"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDM28012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="204" mass="23159" checksum="25FD77D11691B6E7" modified="2014-04-16" version="1">MLSLVLTVFFLHVAIFLVNTVGASTVDGLLWLLYLKLPTSTSRTARKQQELKRQVLEQKHEMNSTSSQDEFAKWAKARRRHDKTMEEYEALNKTLTSKKSSFDWTVKIARWISTNGLKMFLQFWYSKTPVFPLPEAWFPYYVEWIVSFPRAPLGSVSIQVWSNVCATSIAFAAELVGALLVQVAGQKKEPKEDAPVGAEGIKAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2024-10-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>W6QFC4</accession>
    <name>W6QFC4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S04</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S04g000369</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QFC4"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM35488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="68" mass="7592" checksum="BB7E3D4D0082C8D6" modified="2014-04-16" version="1">MEKRTIGSFSTVSSGLDMTWISNGTRQAIPRTCQIRPQICVDNQQKVGSYHDIQADQGFLQPSRRPPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2024-10-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>W6QFC9</accession>
    <name>W6QFC9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S04</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S04g000091</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QFC9"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM35210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="68" mass="7803" checksum="04A2948F2D83F92C" modified="2014-04-16" version="1">MRGRIKRIAPRDLAGRSGRLWLWNGYGHFSSVKTSGLYGVKLACNIKYQHHDLSGLEDRDMTYGQIHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>W6QFG8</accession>
    <name>W6QFG8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Small GTPase superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S02g003025</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QFG8"/>
    <dbReference type="STRING" id="1365484.W6QFG8"/>
    <dbReference type="OMA" id="KELCGEY"/>
    <dbReference type="OrthoDB" id="5976022at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM32874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="164" mass="18583" checksum="C172B0EDFCA658F3" modified="2014-04-16" version="1">MSDSLALVLVGDEGVGKTALAVRFCLEQYAEGSEPTLDDSYRTRMVVDDRPCVLEIIDTAGRDEHAALREDHIRNGDAFIIAYSITSRESFSHVRAYYDNIKEVKKVLAENTVQQPPSEHPCRVPIILVGMKKDLEFQREISFEEGRKFGESLDCWFYETSCGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W6QG13</accession>
    <name>W6QG13_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S02g003286</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM33134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QG13"/>
    <dbReference type="STRING" id="1365484.W6QG13"/>
    <dbReference type="OMA" id="WGVWCRR"/>
    <dbReference type="OrthoDB" id="5395975at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="294"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM33134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="428" mass="47111" checksum="07B080A45D1AA30D" modified="2014-04-16" version="1">MIQLPDSQILVHIAAASTAQDDARYRAQVAAILEFQCATRQPLMQMSKSFSNDRDSAHPFSAGAAVHSSVPPTTQHEASPILREAFRPADTTLPSDQRLIPETDGAAPRNIISNQLSSLESLISVIPDSQPEIADELVHAEQSRAELSPQPQRAPPPKRRRIAPASPDPAQPVLISDSPATDQPAAHHRVISIQNQVPISSLGSVEGPSTPSHHMSTNTTTPNPINLSTLPLEIHPPRPPISTASFTTHITPTLSMLTERLNPARIYNPSTQTRPLDPLERGYWLVQLAIEDQTHERDRDRDPADLPLVPSPNSKHGTTNPNANAMLNSNPKENKRSWPSPLFHAFWSFLSDFVGRDGRAGWGVWCILEAATPPSTRSSNTHVSLKVYAWGEVAMHVYLLLFLASERRVRGMGVQWRDAREEVVIQMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W6QG93</accession>
    <name>W6QG93_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S04</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S04g000704</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QG93"/>
    <dbReference type="OMA" id="CASKCET"/>
    <dbReference type="OrthoDB" id="4510367at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM35823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="133" mass="14232" checksum="BAB396449ADA8EF8" modified="2014-04-16" version="1">MVEMILRTMPLPVTVNAACRDSVAQDTIAFFSSAPLTLDTNVTDSVACASKCETLNGCESWLFNTGGWYDLFRNSAVATASSPHFVFGGCAKDSPRSSVVVSSIASATPIVANLHGKRHLEAHKKHGHSFHSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W6QGP9</accession>
    <name>W6QGP9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Phox/Bem1p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PROQFM164_S03g000083</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QGP9"/>
    <dbReference type="STRING" id="1365484.W6QGP9"/>
    <dbReference type="OMA" id="RERKQFF"/>
    <dbReference type="OrthoDB" id="418595at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd17781">
        <property type="entry name" value="CBS_pair_MUG70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17782">
        <property type="entry name" value="CBS_pair_MUG70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051462">
        <property type="entry name" value="CBS_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053793">
        <property type="entry name" value="PB1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000270">
        <property type="entry name" value="PB1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48108">
        <property type="entry name" value="CBS DOMAIN-CONTAINING PROTEIN CBSX2, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48108:SF26">
        <property type="entry name" value="CBS DOMAIN-CONTAINING PROTEIN DDB_G0289609"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00564">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00666">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54277">
        <property type="entry name" value="CAD &amp; PB1 domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51745">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="649"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="5">
        <location>
            <begin position="112"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="5">
        <location>
            <begin position="179"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="5">
        <location>
            <begin position="282"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="5">
        <location>
            <begin position="348"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="PB1" evidence="6">
        <location>
            <begin position="486"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="454"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="606"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="48"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="74"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="91"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="454"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="607"/>
            <end position="621"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM33359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="674" mass="72966" checksum="2776C1E0EB271366" modified="2014-04-16" version="1">MSATGTFRGKPNQTIGRGRLPDFASDPSASHIPRPPRPDSSVISTTATSDVGTPTSTGTGTMSAASSRQRQNQSKRDEAIRRKMEADLSKKRNTPAKSRSSRKAPPGTVLALKPSQALQIKPTMSIAEAAQLMAAKREDCVLVTDDNERISGIFTAKDLAFRVVGMGLKARDVSVAEIMTKNPLCARTDTSATDALDLMVRKGFRHLPVMDENQDISGVLDITKCFYDAMEKLERAYSSSRKLYDALEGVQTELGSSQPQQVIQYVEALRSKMSGPTLETVLDGLPPVTVSVRTTVKDAAALMKENHTTALLVQDQGSITGIFTSKDIVLRVIAPGLDPSTCSVVRVMTPHPDFAPSDMSIQAALRKMHDGHYLNLPVMNEGGEIVGMVDVLKLTYATLEQINTMSTQDDEGPAWNKFWLSMDHESDSMVSGGHSQQLNTPHRSVISPDLTRSGYDNSLLPNDSASHHGDDHSAISQHYPIEPAAPTPFPFKFKAPGGRVHRVNVLTTSGITDLVLQVTAKLGKEVEDVGGEATVEEGRLSHTGYALSYMDNEGDTVSITTDQDMTDAIDLARRTHRDKVNLFVHDPAQAPNTVFEPHHVKIVTPMEEQSSAEEPTSQDSPVSKALPQPQVVPLHAPEEQYIAGVPNDLLLPGAIVTLAAVIVGVFILSRPGHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W6QH53</accession>
    <name>W6QH53_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S01g002763</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QH53"/>
    <dbReference type="STRING" id="1365484.W6QH53"/>
    <dbReference type="OMA" id="KNPHTHD"/>
    <dbReference type="OrthoDB" id="5373744at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045138">
        <property type="entry name" value="MeCP2/MBD4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15074:SF5">
        <property type="entry name" value="5-METHYLCYTOSINE G_T MISMATCH-SPECIFIC DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15074">
        <property type="entry name" value="METHYL-CPG-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="573"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="699"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="44"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="105"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="130"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="190"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="253"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="612"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="710"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="734"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="760"/>
            <end position="772"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM28952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="772" mass="84569" checksum="B2CA55CD8DE1778C" modified="2014-04-16" version="1">MPGLEKSEAASFLESRTSLPYPTFSKAHSKEGVRASIPTPDPTDLTHDEGKNGHREDHHAPPSPPLTGLDQESRKGSIGKGSIINEDEKETDKPKKRTSIKIRASEVNRSSSSLRSKPDDTTKSKSSKTSRTETPTKHRTSKDEGEALPRSSSYKSKTKVSDDRTLPKRSSRSTMSASQSNVTLRDNGGESVNGSDATSIAPNQQHSAPRKPMTPPAKPPSRTQNRSAMSRRRTASDESIDFVKPVNPNSFGAPPPPPPPPEMPATIPRVDYLLKNGGLENKVSRALLASLGQNDPFSQGQPQSQANAGKIFDPYHRLLDDYQKVMSKNGSLAVATGYRSVARRLLDRLEAVFARDISSEPCSCQICDRTEADGRPDGVSWGEVLELVSGRRELPMWPPFTMAPTTVDTGVPGDEHIPMQKLDVDVPEEYRDHFIRQSRKTKVAVDKWLYEQKDPGTSAPNEVDDETLTFAMLTHLEPRQRSLLCSLLGINSSTPVPRSDDEMPRHKPSALISSASAIQRLYRLPSLPRDPETAMYMLNNPTLHHVLATLSAISDDEWEILISGRFDGFLRSGAEDPGPTTGARWSGSRSNTPLGGSVSRGPTPNYMDGSFRPSSQVNGAPSSPASFGGPIALDEETEIAALAEVERDIFLGMEALEDAFEALHCKAEVVRRALRERGAGLSVASQSRRGSFVEARLGTPFSGVGTWESGGEDDFLDDECSLAPDDSASNISSNRRRRPKRRTERRTPAPVEEEDEEDDGLGRRDTRPSRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2024-10-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>W6QHH7</accession>
    <name>W6QHH7_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S01g002883</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QHH7"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM29072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="61" mass="6868" checksum="F9C90027E8334CE4" modified="2014-04-16" version="1">MLKSRCSLLPDCARRNAVMQQPTSTNPWVRQVSYAIHASWVEFKYLDLHSPASYTLAAISG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W6QHM7</accession>
    <name>W6QHM7_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S01g002929</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QHM7"/>
    <dbReference type="OMA" id="WIPRIID"/>
    <dbReference type="OrthoDB" id="3796275at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM29117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="251" mass="28465" checksum="7C027DA78D01E605" modified="2014-04-16" version="1">MKSPTITTQEAVESCLPDLLKATHKTLSSAIHKVKYIGPLSQWQDFEEDVKNNNPKRWTSAVIDYRISNRDLRQEEVYVADETGVQGRFQQAVGQVLGAVFRAEKKNLRFGDFKSAGITYDKTPDIAMVSPGSPVMLRAVGELKVPWVMAHNLRKRYGADQELRLALGQVLEYMIDLRLPYGFHSTYEETIFLRHVQVNGQWRVEYSPVIQSTATDVSLKKCFWHLSSLALQGNPVQNPALKDDLVTDEIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W6QHU0</accession>
    <name>W6QHU0_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">laccase</fullName>
            <ecNumber evidence="4">1.10.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PROQFM164_S05g000196</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>4 hydroquinone + O2 = 4 benzosemiquinone + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:11276"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17594"/>
            <dbReference type="ChEBI" id="CHEBI:17977"/>
            <dbReference type="EC" id="1.10.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the multicopper oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.10.3.2" evidence="4"/>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QHU0"/>
    <dbReference type="STRING" id="1365484.W6QHU0"/>
    <dbReference type="OMA" id="SFWIRAI"/>
    <dbReference type="OrthoDB" id="2121828at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052716">
        <property type="term" value="F:hydroquinone:oxygen oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046274">
        <property type="term" value="P:lignin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13854">
        <property type="entry name" value="CuRO_1_MaLCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13880">
        <property type="entry name" value="CuRO_2_MaLCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13901">
        <property type="entry name" value="CuRO_3_MaLCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000021">
        <property type="entry name" value="Extracellular dihydrogeodin oxidase/laccase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000038">
        <property type="entry name" value="Extracellular dihydrogeodin oxidase/laccase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000046">
        <property type="entry name" value="Multicopper oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF502">
        <property type="entry name" value="MULTICOPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0186">Copper</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0439">Lignin degradation</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004879834" description="laccase" evidence="13">
        <location>
            <begin position="20"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="16">
        <location>
            <begin position="92"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="14">
        <location>
            <begin position="216"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="15">
        <location>
            <begin position="429"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CDM36363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="585" mass="65032" checksum="D82793B4BF049661" modified="2014-04-16" version="1">MNLQAFLLLAFSLSASVVAIPQNAASSVNVQLQNHRPTTTTKITKPTGTPCVGNTPLTRSRWCQYDINTDYTQIVPNTGVTQEYWLDVEELVAAPDGFSRPVMAVNGTIPGPTIFADWGDEVVIHVTNSLHNAKNGTSIHWHGIRQNYTNGNDGVVSITQCPTAPGSTITYKWRATQYGSSWYHSHIGLQAWEGVFGGIVINGPATANYQVDKGSLFLTDWSHPTVDELYLEAQTIGPPTLDTGLINGTNVFGNGTNSTGTRFQMKVNQGSSYRLRIVNSAVDTHWKFMIDNHTLTVIAADFVPIKPFTTDYINIGMGQRYDVIVTANKRQISDSFWIRAIPQEACSENANPDNIRGILYYGNSPNTPTTRPYTFPDECIDEPASSLIPQVPKTVSAADWNNLTDVTLGRNTANLFRWYLNSTTMQVLWEDPTLLQLFNNENTPNFTESSGVIELPRANEWVYLMINTSFPVTHPIHMHGHDFFVLAQGSNPWDGSVATNNPPRRDTAMLNGNGYLLMAFETDNPGAWLMHCHIGWHTDEGFALQFLERESEIEPLIDRQALEDNCASWNAYDEAFDIEQDDSGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W6QI22</accession>
    <name>W6QI22_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S03g000553</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QI22"/>
    <dbReference type="STRING" id="1365484.W6QI22"/>
    <dbReference type="OMA" id="AMWDNSK"/>
    <dbReference type="OrthoDB" id="4364947at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="120"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM33829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="342" mass="38569" checksum="313FCB58E691B640" modified="2014-04-16" version="1">MVPTDFAHRPKAQLIGKLQQSTRDLISRSTAMWDNSKYRYHQSIMEIRHKPANTINNSTDRCHQSTELMLYRPVSKRNQSADQLHRVARVEDTTQQVGARDGQTQEQTPPQSRFYSRAFNSQSTNSSPNPKTTSRSTKVKSIKSASVTGPSLSLEEQIGGFYKATILVRSTVKQARQLRDDKRALLGEIELEWINSTITGAETAANDLAASVKRFKQSSPQNRCSWKRRDYEVTLEKESRVLLAHDKVKTVLSHLGSLQLTLGKDELFFSPSEVSMVASAILELPSETTVLSDFELLPVKPERPIPKIVVTQYDDDNEYSHSYQSSPPSYEASGMNAMAEFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W6QIC3</accession>
    <name>W6QIC3_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ribosome recycling factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PROQFM164_S05g000013</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Necessary for protein synthesis in mitochondria. Functions as a ribosome recycling factor in mitochondria.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RRF family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QIC3"/>
    <dbReference type="STRING" id="1365484.W6QIC3"/>
    <dbReference type="OMA" id="NVICGEE"/>
    <dbReference type="OrthoDB" id="407355at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1360.40:FF:000020">
        <property type="entry name" value="Similar to ribosome recycling factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.20">
        <property type="entry name" value="Ribosome-recycling factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002661">
        <property type="entry name" value="Ribosome_recyc_fac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023584">
        <property type="entry name" value="Ribosome_recyc_fac_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036191">
        <property type="entry name" value="RRF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20982:SF3">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOME RECYCLING FACTOR PSEUDO 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20982">
        <property type="entry name" value="RIBOSOME RECYCLING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01765">
        <property type="entry name" value="RRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55194">
        <property type="entry name" value="Ribosome recycling factor, RRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosome recycling factor" evidence="5">
        <location>
            <begin position="96"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="47"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="215"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDM36180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="268" mass="29384" checksum="7FFB6805468EAF20" modified="2014-04-16" version="1">MQRIIAQSIRSSCPRLVEHPQTTRSLCLLPRAQRAVPLNRREFANSPALYKKKDKAKKASASASASEPEESSSAPSEDPFDLSQLHNGISTAVARLKDDLSKLRAGGRFNTAVLESLRVHLSKDSKDSVKLGDLAQVVPKGGRMITLLAAEEDHLKPLTSAIVSSNLSLTPQPDPHNALQLNIPIPPPTKESRDKNVQAAKQAFEKAAGLVRDSRGAMHKRLQDMQKKKLARPDDVRKAHDQMEKITDQGQKEAKDAFEGAKKTLEQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W6QIF5</accession>
    <name>W6QIF5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Genomic scaffold, ProqFM164S04</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PROQFM164_S04g000652</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QIF5"/>
    <dbReference type="STRING" id="1365484.W6QIF5"/>
    <dbReference type="OMA" id="LNAWSCV"/>
    <dbReference type="OrthoDB" id="67317at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056552">
        <property type="entry name" value="Ribonucl_Kappa"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23489">
        <property type="entry name" value="V-ATPase_su_f"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDM35771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="88" mass="9299" checksum="9D3AD151F329F303" modified="2014-04-16" version="1">MKPVVSALNAWSCVIISAFAIIILSVLGSLYSSNNHAYTGSEGEPEDGPAVAASIYIAVMVYAGFFVFCGLQAYLHMRDSRGGAISLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W6QII0</accession>
    <name>W6QII0_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S01g003199</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QII0"/>
    <dbReference type="STRING" id="1365484.W6QII0"/>
    <dbReference type="OMA" id="RTEIMDH"/>
    <dbReference type="OrthoDB" id="10003767at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051035">
        <property type="entry name" value="Mito_inheritance_9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36091">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36091:SF2">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM29387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="107" mass="11846" checksum="B8AB8BC0542F7F0C" modified="2014-04-16" version="1">MLTRRIFSHAGEPWEGNNVPLQADIVLITKLWNEYSTGPCPISFSSAEADSIIHLQSMQEEVDLQLKLVRDFIGVGVDGWTSPDAYEAAYSCARQMKVDGLASLDTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W6QIR2</accession>
    <name>W6QIR2_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S03</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S03g000823</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QIR2"/>
    <dbReference type="STRING" id="1365484.W6QIR2"/>
    <dbReference type="OMA" id="WRARAYN"/>
    <dbReference type="OrthoDB" id="72441at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM34099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="831" mass="94614" checksum="6A1D59E587A547CA" modified="2014-04-16" version="1">MLLRGRPCLRRRLSAVLDTVATGPYEPLLFLYPRWAAPALQRRQISSLKSIDTPARIGHTSSGPIRAAVRPSPSLSRHSRQWISSVSSARSPDESNLHPSPAVVGENSNIRKGKETGSDDLNESGGGRLSAGQKQSVNSLADAEHATSREPLRGFALTRAKRIQQGRLHNKPLNAKPSSPTQRQLFLRNTSIRDRKKLRFREYMKKKYQSRSAKLFDNAWFDTKEILDQVYRDIRKIPQKSLNKKEILVPEETLALFSGVTRYTLKENIWYIPLHNGCRVHILPASQSKGLLRRVVLSATDHIMALVEGHFTRAQSLQAMGDPLVDIHKPPVPMCISRGAMQRSKLPVPLVRGNWHFGQTSDSSSNLDEILLPRPVIATVKEFNEHIEDVTSARQPTLDEKAMSLSKLPHLVRVKRHLEALFMEGTYSNYISTAALNNALEFLCRHEFLQTARSLFSCTEHVATTDTYNILLRAAARRQDVAVFRHFLRMMPRLHMRPNSETWLALLSALVDPSEKAQLIEHMVQRGHMSNLSTIHSALQETIQDSLLVHLDSGQDIGSFIGLMTNTWGANWFSPSIIGQMFSVLARLKKFDSIDRLMEICIDNKLTVDSYPLGHIVQALGANIHVALQYTLRFFEHPSFEVTSQNWEDLFLAAFRHRQYNICLVLWRYSCMKRTVTYKMKQAVLTSLCRNASFGKPTRLNKDLWSSDAGKVIIGIDQNHESYRLPDSILDDIPSEFRHNPILYLIGWKPRGEQRDLQIRLANALIKRDMILGATRYVPQHPSPIMLDAASILDQEWRGVPRPLTWKMQNAIQVPIVRKDKDREQDKNEDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W6QIW3</accession>
    <name>W6QIW3_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S03</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S03g000883</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QIW3"/>
    <dbReference type="STRING" id="1365484.W6QIW3"/>
    <dbReference type="OMA" id="AEDVTMF"/>
    <dbReference type="OrthoDB" id="5185064at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038732">
        <property type="entry name" value="HpyO/CreE_NAD-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052189">
        <property type="entry name" value="L-asp_N-monooxygenase_NS-form"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40254">
        <property type="entry name" value="BLR0577 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40254:SF1">
        <property type="entry name" value="BLR0577 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13454">
        <property type="entry name" value="NAD_binding_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-dependent urate hydroxylase HpyO/Asp monooxygenase CreE-like FAD/NAD(P)-binding" evidence="1">
        <location>
            <begin position="15"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM34159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="639" mass="70661" checksum="CC1848A3635A4CD0" modified="2014-04-16" version="1">MPSAVRPSEMHTHVAIVGAGPRGTSVLERLCASAPEYLVPGARLTVHIVDPSPPGAGHVWRTKQSDQLLMNTVSSQVTLFTDDSISCSGPIRPGPSLYTWAADKIPGLGPDDCGTRAQYGQYLEWIFQETVRQAPPQVQIEVHPAFAVRLYDTSYGQQTLKLSNGRTLSSLAAVILAQGHVPLLLDIEQLKINAYAELNGLHHITPSNPADVDLSVIAPGENVFLRGLGLNFFDYMALLTLSRGGSFSETPNGLKYHPSGNEPRMIAGSRRGIPYHSRGDNGKGAYGRHMPLVFTEEVINAFRKHSDAGKAPDFLQDIWPLVSKEVETVYYLTLLKRDKLDQTDFQKRFLETEPKSPEEAQVLRDFGISEEKWWSWERIQRPQGDQVFNTTTEWREWLIAYLREDAKEAALGNLNGPLKAALDVMRDLRNELRLIVDHNGLTGASHRENLDRWYTPLNAYVSIGPPRQRIEQMIALMDAGVLEVLGPRPQVKAQDEAWLVPGEPIRVTTLIEARLPEPKLRNTGDELLSHLFKTGQCRAHTIDGYETGGLDVTQSPYHLIDTHGRAHPKRFAVGVPTEGVHWVTAAGARPGVNSVTLCDTDAVARAALSAAAIKAKITQTKIDVKTFPCIEVSKLRVHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W6QIX8</accession>
    <name>W6QIX8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S01g003359</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QIX8"/>
    <dbReference type="OMA" id="MLKETAM"/>
    <dbReference type="OrthoDB" id="4364385at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004879639" evidence="3">
        <location>
            <begin position="20"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="142"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM29547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="169" mass="18881" checksum="54E9D37104F4B0AB" modified="2014-04-16" version="1">MARKLALLVILMHAIQILALPTPYENSIAFKSVLSGITQNNRHYFPETIPDQDELIVMLKETAMREAGFVLSSNPDPQSKEHKTETELHKSLPNPYAAIGTDATAKPQPNSYPKPRQSKSKSESRVKESFVVALGSYNYPIYWPPFGFFVIAAAVVCFCTILRGIRAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W6QJH1</accession>
    <name>W6QJH1_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Sorting nexin-41</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">snx41</name>
        <name evidence="11" type="ORF">PROQFM164_S03g001068</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sorting nexin family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QJH1"/>
    <dbReference type="STRING" id="1365484.W6QJH1"/>
    <dbReference type="OMA" id="CRRMKEV"/>
    <dbReference type="OrthoDB" id="289314at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06867">
        <property type="entry name" value="PX_SNX41_42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044106">
        <property type="entry name" value="PX_Snx41/Atg20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051079">
        <property type="entry name" value="Sorting_Nexin_Autophagy"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46979">
        <property type="entry name" value="SORTING NEXIN-41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46979:SF2">
        <property type="entry name" value="SORTING NEXIN-41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0072">Autophagy</keyword>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="7" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PX" evidence="10">
        <location>
            <begin position="94"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="216"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="446"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="257"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="448"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="481"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDM34344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="627" mass="69598" checksum="867840C8A3E882B8" modified="2014-04-16" version="1">MWNDEDNNPYGAFDQHQSGLSDSLHSAALSPPLYEHDSSPPSSRDSNGEPPDYITHTDDLSDPEDEAEYGAASEQYPRKSVYDSRIEQILYENPDMPILITDAGKNHEGGGGFIVYTIRTADLEVRRRYSEFASLRQTLVNLHPTLVVPPIPEKHSMADYAAKPTRAKDDMAIIDLRKRMLGVFLNRCRCMKEIREDGVWWRFLDPNVSWSEVLSSHPASSVPKNNLKAPPLDPANPTPAHGWLPVPSASAKLKTSGGITTASANPASPTSPNEQEQPSFPGPEMLGRFPPESRKLSEQELDPYFINFEASTRELELLLQGNIEKVNRRTLSHLSGLSADLMELGARYNGFSLSEQSPTVAAAIERIGQAADTSYIETEELSSALSASFAEPMRESAQFASVVRGVLRYRVLKRVQQEMTRDELSKKKTLLDSLERSELEAKRIEQYLNRTNPHSGTTKPRSLSTSSASEGGSGPIMSADSGLQSTHTDSISSLPGSQIGGLKRSDPSVHGHRKTSSGTFVANKIFGRISHAIHGFADVDPERTRRDQIGKTKESLIQLEQALEVSEKDVKDASAGVLNDLKRFQKDKEADLRRYMVAYARCHLDWARKNLETWTEARDEVDKIVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W6QJH6</accession>
    <name>W6QJH6_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S03</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S03g001073</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QJH6"/>
    <dbReference type="OrthoDB" id="4339989at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM34349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="106" mass="11845" checksum="F5B28406CE639FEB" modified="2014-04-16" version="1">MADSRTDMRSDRVWSYQMDDILCDRDSVNIYASLTLSEKLDLDTESISPTRSSNYSCDISSSSTIPSVTTIRRKVLLGMFVSLEATPNRIEALVRFGLVAIIFITA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W6QJI1</accession>
    <name>W6QJI1_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Chromosome transmission fidelity protein 8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PROQFM164_S05g000413</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the CTF8 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QJI1"/>
    <dbReference type="STRING" id="1365484.W6QJI1"/>
    <dbReference type="OMA" id="YLYVGKH"/>
    <dbReference type="OrthoDB" id="121932at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031390">
        <property type="term" value="C:Ctf18 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018607">
        <property type="entry name" value="Ctf8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28605:SF1">
        <property type="entry name" value="CHROMOSOME TRANSMISSION FIDELITY FACTOR 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28605">
        <property type="entry name" value="CTF8, CHROMOSOME TRANSMISSION FIDELITY FACTOR 8 HOMOLOG (S. CEREVISIAE)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09696">
        <property type="entry name" value="Ctf8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM36580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="152" mass="17032" checksum="32F3B7E4C50673A0" modified="2014-04-16" version="1">MPSIKLQPRCSGSAKRTTTASTPNNPLPALLQTPSGLALLELQGTINVPSGDEDDIDYSTSTDNPASTFETPIGKLMFPDYSVHNPDDTKWMKRAYMYVGRYQRMTGEVKKLPRPIAVLQRRQAAESEELEVVEIVRYKIFFKSRPEPVTTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>W6QK09</accession>
    <name>W6QK09_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Endoplasmic reticulum chaperone BiP</fullName>
            <ecNumber evidence="4">3.6.4.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Immunoglobulin heavy chain-binding protein homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PROQFM164_S03g001288</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER. Is required for secretory polypeptide translocation. May physically associate with SEC63 protein in the endoplasmic reticulum and this interaction may be regulated by ATP hydrolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.10" evidence="4"/>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QK09"/>
    <dbReference type="STRING" id="1365484.W6QK09"/>
    <dbReference type="OMA" id="VQRDIKH"/>
    <dbReference type="OrthoDB" id="2401965at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006986">
        <property type="term" value="P:response to unfolded protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd10241">
        <property type="entry name" value="ASKHA_NBD_HSP70_BiP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.10:FF:000009">
        <property type="entry name" value="DnaK-type molecular chaperone BiP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000153">
        <property type="entry name" value="Endoplasmic reticulum chaperone BiP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000172">
        <property type="entry name" value="Heat shock 70 kDa protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000001">
        <property type="entry name" value="heat shock 70 kDa protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000026">
        <property type="entry name" value="Heat shock protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042050">
        <property type="entry name" value="BIP_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001413">
        <property type="entry name" value="PRK00290.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0143">Chaperone</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 16" id="KW-0732">Signal</keyword>
    <keyword evidence="10 17" id="KW-0346">Stress response</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004882104" description="Endoplasmic reticulum chaperone BiP" evidence="16">
        <location>
            <begin position="40"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="651"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="661"/>
            <end position="673"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CDM34564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="673" mass="73835" checksum="4D16ECF8EDA7BD94" modified="2014-04-16" version="1">MARLSARDGASKPFAWTTIFYLLFVLVAPLAFFGNTANAQEENSPESYGSVIGIDLGTTYSCVGVMQNGKVEILVNDQGNRITPSYVAFTDEERLVGDAAKNQYAANPERTIFDIKRMIGRKFDDKDIQKDIKNYPFKVVKKDGKPQVKVDVNQVPKTFTPEEISAMILGKMKEIAESFLGKTVTHAVVTVPAYFSDAQRQATKDAGTIAGLNVLRVVNEPTAAAIAYGLDKTGDERQVIVYDLGGGTFDVSLLSIDNGVFEVLATAGDTHLGGEDFDHRVMEYFVKQYNKKNNTDVKKDLKAMGKLKREVEKAKRTLSSQMSTRIEIEAFHNGEDFSETLTRAKFEELNVDLFKKTLKPVEQVLKDAKVKKSEVDDIVLVGGSTRIPKVQALLEEFFAGKKASKGINPDEAVAFGAAVQGGILSGDDSTVDVVLMDVNPLTLGIETTGGVMTKLIPRNTVIPTRKSQIFSTAADNQPTVLIQVFEGERSMTKDNNMLGKFELTNIPPAPRGVPQIEVAFDLDANGILKVSASDKGTGKAESITITNDKGRLSQEEIDRMVQEAEQYAEEDKAIKGKIEARNSLENYAFSLKNQVNDENGLGGQIDEDDKQSILDAVKEVNDWLEDNAATATMEDFEEQKEQLSSVAYPITSKLYGSASPPDEDDEPLDHDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>W6QLN8</accession>
    <name>W6QLN8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S05g000729</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QLN8"/>
    <dbReference type="OrthoDB" id="2831558at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM36896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="139" mass="16068" checksum="50C5DD544A24B634" modified="2014-04-16" version="1">MRYRRFNLQALLNASAKPGGDAGTTLPRCWDREDLFSLRNFLIKLVARWAELKYEQESLPVDFGEEELLRHTDEMNLLEGISGIVHQLQDAGLIPLGGIVRPEYYESAMEANERFRQESIGLAENKSQRDFHAKVWPYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W6QM07</accession>
    <name>W6QM07_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S02g000747</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QM07"/>
    <dbReference type="OrthoDB" id="10497845at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM30597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="193" mass="21820" checksum="F9C00427342C56C0" modified="2014-04-16" version="1">MTAVRSESLHWKPQPDTDSSNTSTRQQLTMTKKQAIDFVNQWYEAGRPIFTKKALQDLGEQLKSRRTMGDKVTVRGLTGAVFEGTVNLGHHFFSTTFANPVEREYIYLDLAIDYNHAGRLIADIMRYPDGIDIPISELIPLRLTHEVYPFGTKEEIWSSKHAGVTFEKERRAWETKLTKSTTSSGLLAVACPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W6QMU2</accession>
    <name>W6QMU2_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S10g000027</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792024">
        <property type="protein sequence ID" value="CDM38213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QMU2"/>
    <dbReference type="OrthoDB" id="4802432at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM38213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="96" mass="11600" checksum="CB74F5F1EDD98B94" modified="2014-04-16" version="1">MECKFYWMSDDLLHRRYEHSFLELAENADTLPPIDIICELEIRTVVYRNIAPETAFRIISRLPRLRSLQAEFDDETYDILRNHLRQDFVLIIEKNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W6QMX3</accession>
    <name>W6QMX3_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S06g000252</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792020">
        <property type="protein sequence ID" value="CDM37291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QMX3"/>
    <dbReference type="OrthoDB" id="4369759at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM37291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="106" mass="11517" checksum="91EDA5F07E12BBDB" modified="2014-04-16" version="1">MIFHGDSLVVLETLFSTNRDPNTFDGYLFVDPTTGACNISSTVTPTEKWLPFAIGASTCPGRLAETRITQVMFAKILYGFDANLEGVDAQLFLHYDGTCGATVIFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W6QNE5</accession>
    <name>W6QNE5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S12g000042</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792026">
        <property type="protein sequence ID" value="CDM38433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QNE5"/>
    <dbReference type="OrthoDB" id="4323916at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM38433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="169" mass="19025" checksum="7003A41917816BCD" modified="2014-04-16" version="1">MDAPNELPGQDRADRQPSEMPIRSDEAYSGAISDSETQMQEAGPKKPLTIEYFQPILETLADLDRHDPKLAFQAARAVGLYRRVWASCEPSGHGGEKVDQKRGILGEAPIKLGNEQDGLQLRPNEQLCFLDSFERALEQTQERLVSVLKEWNQVLRSDLAVMIDTDRYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>W6QP59</accession>
    <name>W6QP59_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Succinate dehydrogenase/Fumarate reductase, transmembrane subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PROQFM164_S04g000760</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome b560 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QP59"/>
    <dbReference type="STRING" id="1365484.W6QP59"/>
    <dbReference type="OMA" id="MNGIRHL"/>
    <dbReference type="OrthoDB" id="588261at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006121">
        <property type="term" value="P:mitochondrial electron transport, succinate to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03499">
        <property type="entry name" value="SQR_TypeC_SdhC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1300.10:FF:000008">
        <property type="entry name" value="Succinate dehydrogenase cytochrome b560 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1300.10">
        <property type="entry name" value="Fumarate reductase/succinate dehydrogenase, transmembrane subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034804">
        <property type="entry name" value="SQR/QFR_C/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018495">
        <property type="entry name" value="Succ_DH_cyt_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014314">
        <property type="entry name" value="Succ_DH_cytb556"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000701">
        <property type="entry name" value="SuccDH_FuR_B_TM-su"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02970">
        <property type="entry name" value="succ_dehyd_cytB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10978">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE CYTOCHROME B560 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10978:SF5">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE CYTOCHROME B560 SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01127">
        <property type="entry name" value="Sdh_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81343">
        <property type="entry name" value="Fumarate reductase respiratory complex transmembrane subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01000">
        <property type="entry name" value="SDH_CYT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01001">
        <property type="entry name" value="SDH_CYT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="117"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="163"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDM35879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="185" mass="20026" checksum="C9DA16621D54D56E" modified="2014-04-16" version="1">MFSQKLAQQSLRRLAVQQPLAMRSSMMGASPVAVALSKNIQTRQVTSNTQDPNEILVQQRLRRPVAPHLSIYRPQIGWIGSSLHRITGVALSGTLYLWATAYLASPALGWHIESASMVAAMGALPFAAKVALKTTLALPFTYHCMNGIRHLMWDLGRGLTNPVIIKTGWTVIGLSVASAVGLALI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2024-10-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>W6QP96</accession>
    <name>W6QP96_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S04</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S04g000805</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QP96"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM35924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="81" mass="9398" checksum="B99C41F08538B471" modified="2014-04-16" version="1">MVYNIGHGQGFKGIVFYLSNQSRNAMRMSMYCTYGLWWRCRLPRTWWMAGVKVDLGDPQFWMANLLIGAGVVARCHTMIYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W6QPF8</accession>
    <name>W6QPF8_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">von Willebrand factor, type A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S10g000084</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792024">
        <property type="protein sequence ID" value="CDM38270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QPF8"/>
    <dbReference type="STRING" id="1365484.W6QPF8"/>
    <dbReference type="OMA" id="TIDIRFF"/>
    <dbReference type="OrthoDB" id="2142040at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34706">
        <property type="entry name" value="SLR1338 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34706:SF1">
        <property type="entry name" value="VWFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="18"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM38270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="362" mass="40248" checksum="668099E55729AE46" modified="2014-04-16" version="1">MGVWNPFSRYRKERKAGTTITGTTVTTPTHRPSWSRGRSPNTSNAQSSDRPPPYQEEIPTIRISAPSEPESDSQYAFLGQFHTIFLVDDSSSMRGELWNEAKEAIAAIAPICTKYDSEGIDIYFINHRPKPNPNRSNYGYGYPYNSGSGYRRSPSGHIPGANFDYNYSPGPRRPTLDASGYHNIKTAQLVSEIFASVIPSGGTGVGARLFDILDPYTKLLEAKETERQAQKHVSGVLARSIELEPVESVKPINIITITDGVFTDDAESIIIKTAQTLDGPACRAIPWQVGIQFFQIGNDEMARQYLDVLDKDLGSRCHDLHLRDIVDTVSWRNRAGERLEGYGILKAVLGAVHKKLDRDLEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W6QPL9</accession>
    <name>W6QPL9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S04</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S04g000925</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM36044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QPL9"/>
    <dbReference type="OMA" id="WYLATIF"/>
    <dbReference type="OrthoDB" id="5413827at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038883">
        <property type="entry name" value="AN11006-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085:SF2">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM36044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="266" mass="30316" checksum="B8F4DA42D6AA8C27" modified="2014-04-16" version="1">MRPTPTPTSTSPSRLLQLPAELRLKIYEYALDVPNDYLVSKPMIVLADHGNTFTARGQYRAISMSPHWVGEDGTARKLLAVNRQLHDEAEDYLYSTHTLFLRNSFNLDRLAEFLDTLSATARARIRSVGFEIFFFVHTQTGVPKRTLKQYEAAGRLLSEKLPMWNSVLLYLDPRYYYPSANVGGRDLTARGVFDLATRFGALCKDVSFYPLPTGDQHLLDEAQQFVWRSRSPMRQSDRSIKGCSAWSLDFKKQMAPSRLRPTSSVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W6QPV4</accession>
    <name>W6QPV4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Probable transposable element</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S12g000064</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792026">
        <property type="protein sequence ID" value="CDM38455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QPV4"/>
    <dbReference type="STRING" id="1365484.W6QPV4"/>
    <dbReference type="OMA" id="KCEDPRI"/>
    <dbReference type="OrthoDB" id="4207519at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00674">
        <property type="entry name" value="CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="2">
        <location>
            <begin position="60"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM38455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="158" mass="18200" checksum="681E83257914066B" modified="2014-04-16" version="1">MPPKRSQSSKDSIEKEGRILLAIQAFKNQEFSNISTTARTFNVPRSTLRDRLSGIQHRATSRANLTKLTAIEEESLRKWIISMDSRGSAPRPSMVREMADLLLKQRGTTPVISVGQNWVTHFVKRHPTLASRFSRRYNYERAKCEDPRIIGEWFDLVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W6QR82</accession>
    <name>W6QR82_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Probable transposable element</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S13g000004</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792027">
        <property type="protein sequence ID" value="CDM38481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QR82"/>
    <dbReference type="STRING" id="1365484.W6QR82"/>
    <dbReference type="OrthoDB" id="3261222at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM38481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="86" mass="9852" checksum="D04D9491C3533501" modified="2014-04-16" version="1">MTGRAAMRTPDPPDRDKREDSPPRLSRPKRTTKPPKNYAREQEIDNEQRKTRPLPKKRIEPKDQPNVATSDNSATESDDLDVSNLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W6QRM3</accession>
    <name>W6QRM3_PENRF</name>
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        <submittedName>
            <fullName evidence="8">Short-chain dehydrogenase/reductase SDR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PROQFM164_S05g000542</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the short-chain dehydrogenases/reductases (SDR) family. ERG27 subfamily.</text>
    </comment>
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        <property type="protein sequence ID" value="CDM36709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OMA" id="WTGINWP"/>
    <dbReference type="OrthoDB" id="9989144at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000253">
        <property type="term" value="F:3-beta-hydroxysteroid 3-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051593">
        <property type="entry name" value="Ergosterol_Biosynth_ERG27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43647:SF1">
        <property type="entry name" value="3-KETO-STEROID REDUCTASE ERG27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43647">
        <property type="entry name" value="DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="291"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM36709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="439" mass="48163" checksum="22F431BB68740034" modified="2014-04-16" version="1">MDQVKSAEQQNMLHILVTGANSGLGFSICCRLADEFLSSHAESESLTIIFTTRSARKAQDTIRRLEAHLQATSPSASAAARVHFVSESVDLGDLRSVRELSRKLVHTLPRLDSIVLNAGLGGWSGISWPTAIWEVCTDLLHAVTWPSYKLAPTGVLTNKQTKTEEEPALGAVFCANVFGHYMLAHNLVPLLKRAHTNGPGRVVWVSSLEATWNFFKIDDIQGLRTDAPYESSKALTDILALTSNLPSTAPWVVDSFLQSETELDTHAIHTNAPDATPRMYLSHPGICATSIIPLILPLAWAMIAAFWTARMLGSPWHPLSTYLGACAPVFLALASQADVEAAEEPYHRAGGGRAKWGSSCGRLGIESAVSTEVDGWGHGGVVGTPVVEADRLRRRKRGAEDLTKEKREEFEELGRQCWKQMEELRIQWDEILDRAEAHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W6QVF4</accession>
    <name>W6QVF4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Zinc finger, C2H2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S03g000266</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QVF4"/>
    <dbReference type="STRING" id="1365484.W6QVF4"/>
    <dbReference type="OMA" id="EHTPEWA"/>
    <dbReference type="OrthoDB" id="2152896at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="146"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="100"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="199"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="329"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="395"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="100"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="118"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="203"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="213"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="353"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="370"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="412"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM33542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="444" mass="47895" checksum="EF43B0885917E11F" modified="2014-04-16" version="1">MASFKELSMSRPLPNTSQRHHTHSISLGALNPNHRVTRRKSVTTAAANAAAVAASMEGGEATSLPMGAHRRALGGRKGLESGSIGNVSGFSSYLSRSINSSKQESSVARKSSPGSDNSDGKPDDRNRRASEGAQLKTEGKRASTAIRCDRCGKGYKHGSCLSKHMWEHDPAWSVTSKLLISKHQQVQLLEAASVLVTMNHDDPPDESAELESELSSGSPGALSEMQDGISSAETTPPPMDSEEDDDFEMSGVPAQWTKRPSISNASGFSRSYQSIPSSSYNESAPLHSPTFSHFRHSSIDTRPSTADTRLHEDDEADLAAAIGLCNFGTPRTGPLSMTRDVPPVPPLPARYLDSSSHPSNQGLYSPQLRPTEEAARRDSEANIFFSRSLNPSLSYKVSDEREVRTTGGDEDQQSRQRRNADVDFGNRSAPADDDDGGVFGHMEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W6QVP8</accession>
    <name>W6QVP8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Genomic scaffold, ProqFM164S03</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S03g000366</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QVP8"/>
    <dbReference type="STRING" id="1365484.W6QVP8"/>
    <dbReference type="OMA" id="MHEFQIP"/>
    <dbReference type="OrthoDB" id="74360at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050982">
        <property type="entry name" value="Auxin_biosynth/cation_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43539">
        <property type="entry name" value="FLAVIN-BINDING MONOOXYGENASE-LIKE PROTEIN (AFU_ORTHOLOGUE AFUA_4G09220)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43539:SF68">
        <property type="entry name" value="FLAVIN-BINDING MONOOXYGENASE-LIKE PROTEIN (AFU_ORTHOLOGUE AFUA_4G09220)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Pyr_redox_3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
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        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM33642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="623" mass="70423" checksum="474434B7C71D6EDA" modified="2014-04-16" version="1">MTKSNDLPPSRERVVPGSCNIEPGEFPETMSESESDVPLDPNTVADRIINQLNSSLSARDKAAVASLFLENCYWRDHLCYSWDFHTLEGSQAIAAFVTEAPPSKIEIDRSSDLKSPHKAPIDFFGDVFGIEFYIKVTTENGQGNGIIRLAEHEGNWYIFTVFTSLIESKGYKENKERPFGVRHGEQQGRKNWRDRRIDEINFEGKDPVVLIIGAGQGGLTAAARLKMLEIDTLVVDREERIGDNWRRRYHQLVLHDPVWYDHMPYLPFPADWPVYTPKDKLADFFETYVKFRELNVWTQTEIKSSSWDENEKRWTVVLERKTENGTETRTLHPRHVIQATGHSGKKNMPVFKGMDDFKGDRLCHSSEHPGANADSKGKKAIVIGSCNSANDIAQDFVEKGYDVTMVQRSSTCVISSESTLEIAFKGLYDASGPPTEDADLHMWSMPSRLFKAQQVKVTKLINQNDAKTIQGLEKAGFKVDSGPSDSGLLMKYFQRGGGYYIDVGGSQLIIDGKVKVKHGQEISQVLPHGLRFEDGSELEADEIVFATGYQNMRTETRVIFGDKVADRVGDIWGLDKEGEMRTIWRRSGHPGFWFMGGNLALSRYYSRLLALQIKALEEGLTTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W6QWK8</accession>
    <name>W6QWK8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S15g000008</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792029">
        <property type="protein sequence ID" value="CDM38544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QWK8"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM38544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="49" mass="5513" checksum="BF5C02B7954D6AE5" modified="2014-04-16" version="1">MFANMLFTGDLAFPNDVQIPYNKITIEAPGPIEWPGIGFDQNRNSLVIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W6QX13</accession>
    <name>W6QX13_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Integral membrane protein SYS1-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PROQFM164_S03g000796</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SYS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QX13"/>
    <dbReference type="STRING" id="1365484.W6QX13"/>
    <dbReference type="OMA" id="EYEMVGM"/>
    <dbReference type="OrthoDB" id="542931at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006895">
        <property type="term" value="P:Golgi to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034067">
        <property type="term" value="P:protein localization to Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019185">
        <property type="entry name" value="Integral_membrane_SYS1-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12952:SF0">
        <property type="entry name" value="PROTEIN SYS1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12952">
        <property type="entry name" value="SYS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09801">
        <property type="entry name" value="SYS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="99"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="156"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="158"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="183"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDM34072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="205" mass="22924" checksum="14A3FAC341A24667" modified="2014-04-16" version="1">MSARRRPPAGSRTELPPLKIVRKILLLQLAYYACATVLILFTTVVYGAPFSLDLVFGWDSLRGDTTLGWMLGLVWMLNCFISVMFLLVFVSRSKLVPDFALTIHFLHLIATTLYTHSLPSNLLWWALQFASASMMTFLGMWACQRRELEPIKFGGHNGSAQAGSSPQASAGDGQQESSFGRGRGRERSLQEYEMDDMKRTGEHAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W6QZY8</accession>
    <name>W6QZY8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S04</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S04g000013</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QZY8"/>
    <dbReference type="STRING" id="1365484.W6QZY8"/>
    <dbReference type="OMA" id="PAKMNTS"/>
    <dbReference type="OrthoDB" id="4590707at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM35132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="170" mass="18214" checksum="A8521FE38CB55E00" modified="2014-04-16" version="1">MNYIRHSFPYAAMRQHIRPSVGLRSPGPAFSRRCFASEKPSGQAKNPRWLLVSIGLGLPISIYLWQRGDTKKPSSKPHTQPRGANQEYSQESEATQVGGQNIKSGSSGGDVPRGMGAPNGPGSISAKQEGLSNADTMNPYVNEPGKSKKGEGETDSVKAKGTIRPGRPQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W6R1L8</accession>
    <name>W6R1L8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hly-III-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S04g000603</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6R1L8"/>
    <dbReference type="STRING" id="1365484.W6R1L8"/>
    <dbReference type="OrthoDB" id="529367at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM35722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="74" mass="8491" checksum="D6998AF1D0092CFD" modified="2014-04-16" version="1">MPTYSYKRSLRIWRCLHMETMNIWTHLLGSVAFIAVSFTPNHSVSILKDLNFTHGDIFAFGSFLTSATCFDSTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W6R2L2</accession>
    <name>W6R2L2_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AMP-dependent synthetase/ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S04g000958</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM36077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6R2L2"/>
    <dbReference type="STRING" id="1365484.W6R2L2"/>
    <dbReference type="OMA" id="KMLIAYG"/>
    <dbReference type="OrthoDB" id="10253115at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031956">
        <property type="term" value="F:medium-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201:SF6">
        <property type="entry name" value="ACYL COA SYNTHETASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201">
        <property type="entry name" value="ACYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="1">
        <location>
            <begin position="26"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="2">
        <location>
            <begin position="469"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM36077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="572" mass="62823" checksum="698C14745D241B8F" modified="2014-04-16" version="1">MDSNLALVYGPTEPQLCLKTMGALIEDQAAQFGDRPAVVFPWQSVRLSYRQLADRSKALAGEMLEMGLHHGDCVGILAGNCYQYVEVFLAGARIGCPVVVLNNTYTPAELENAVLRSSCKVVFHATSIGSRDLTGHIRILQGTQYPNPALPDLRRIISLGLGEFRTGAIEVQLYDTVTSNSPSVSINNATLEHAERQVTPQDVVNLQFTSGTTGSPKAAMLTHTNLINNAQFVGRAMQLTPEDVICCPPPMFHCFGLVLGFLSSFFYGSSIVFPSDYFDVAKVVDAIIDEDATVLLGVPTMYVAELEVMAKTGQRPRRLRTGLASGSAVSQNLMNQLREIMGVEKMLIAYGMTETSPVSFITSLDDSDEKGTTTVGRVIPHTAAKVIDEKGNTLARGQQGELCTSGFVLQKGYWKNEEKTKEVMRRDENGVLWMHTGDEAMIDSDGYAHITGRIKDLIIRGGENIFPREIEERLMSHASVSEASVVGIKDERYGEVVGCFLKASVQFQRPSIQELQQFVGERLGRHKAPKHVFWLGEKGVGDDFPKTGSGKHQKHMMRDIGNRLVGMFKAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W6R2Q5</accession>
    <name>W6R2Q5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Oligopeptide transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PROQFM164_S04g000993</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM36112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6R2Q5"/>
    <dbReference type="STRING" id="1365484.W6R2Q5"/>
    <dbReference type="OMA" id="LSECFCN"/>
    <dbReference type="OrthoDB" id="8904098at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071916">
        <property type="term" value="F:dipeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000085">
        <property type="entry name" value="MFS peptide transporter Ptr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000109">
        <property type="entry name" value="POT_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11654">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00854">
        <property type="entry name" value="PTR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="179"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="213"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="271"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="296"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="428"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="460"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="539"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="566"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="49"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM36112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="618" mass="67667" checksum="F876671E57900BB4" modified="2014-04-16" version="1">MVSTEQLQTWERSSSAPTAVTGSVRCETILTDTSVVAARGVSEVKSLHLDEGLGGDSQASQESQEPYDDVFTPPTDEENQTLRKVAANLPLVAFSLCLVEFAERASYYGAQTLFSNFVEFPLPEGGNAAGAPPRGTQKTAGALGWGLQASTGFVLLFKFLAYIVPIFGGYWADTYVGRYKAIIIGVFICGVAHIIQIVGAIPSVLQKGKANAAPPFVIGLLLLAIGAGIFKPNISPTVLDQHKSQTPYVKTLKSGENVIVDPETTNTRTMLLFYMFVNIGAFYMLATTYAEKYVGYWLSFLLSGIIYFFLPILLLAVYKRTKKQPPSGNKELAEAFKIGWTALVQSKFQFWRKDFWDLAKSANLRSKGIEVSWTDTSVSKVAKTIEACDIFWFFPIYNLNDGGIGSVATNQGASMITNGAPNDLLNNFNPLTIIVVIPILTFVIYPFLERRKLKPGPITRMTIGFAVATLAGIVGALVQWKVYQLSPCGTHASTCDDVADISIWWQIPNTSLSAISECFANVTAYEVAYARAPKSMKGLVIAVFLFMTALSSALGEILIPATADPWLIWIWAGPAVALAVQTVIFWFRFRHLNSENYFADNVVSDLVEEEQVSLKREA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>W6R8L7</accession>
    <name>W6R8L7_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type DNA-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PROQFM164_S10g000021</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792024">
        <property type="protein sequence ID" value="CDM38207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6R8L7"/>
    <dbReference type="STRING" id="1365484.W6R8L7"/>
    <dbReference type="OMA" id="CTKNGHQ"/>
    <dbReference type="OrthoDB" id="2354469at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47783:SF1">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47783">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="39"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="74"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="191"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="820"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="105"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="197"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="820"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="884"/>
            <end position="919"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM38207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="1018" mass="111597" checksum="0F72D8E40E618F77" modified="2014-04-16" version="1">MSLPSPKKKNGGIPSVPRQIRFVATDGQPQTKRRRVNAACLTCRRRKIRCSGEQPVCKTCSDYKHTCLGYTESTAHRRTQSDSASRAPPISAPNELSQPAARAVESSSPEPVSTTIAKPSADKPNAKPPGSKEVYSWDTSANKDLDTQAVGDSPASGRTSVSSGGRTHVPYFRYFGPTAIVPGFKQMVVQVRGSRKSNPSTSSESLSPLRSPKLSDIHTKPLATAADNRDSRDANIPFYDRDDALPVSNIVSHLCELFFAHLGCSFPFLQRERFLQDLKEKKVDTMLVDAVCSLAARFSIHPSLDPPQAPPIDRSQPPLDDKKWDRGLPFGHRAMSGLVDSLPCPTLSAVQACLLLAYEQFGSNHDSGLWMYLGISIRMAQDLGLQKLQGLKHNYGKTGVTPSEVMTGHAGKLREEQYDDLDVHLTPKTTSQTLVEERARERERVDSFWSIFFLDRVISSGTGRPVTLRDEDIELCFPLQSESQLPNGWPAPFPPLIRIIHLYGRVTDLINGIQDVNLVTPDTLKMLAGMESDLTGIYQHLSPRLHFNAANFQAYVKAKEGTNFILLHFWFHTLIVLLHQPTLLNSFGGSIQHLYPNSRELSMSSAKTIADILSFSELVDGKSFIGNPFTSQPMYIAACAFLMESAYYASSSSGAESQQPQPLLANQSSGFVMPAIESSNGTERKSMAKHILLASAAKENYQRCYKALKALNTYWEGTGYILTVLDQKAKGIVDPLLYAVEEMEITQGIAPGQPPGPGAWCAGNAPTDSVFDPERPAGVADISSDGKWSPHIDPSQAIGWALTGATNSSQPNLSLLYQMSTTEAESSPNRPTYSSQYSHSYPVLPTNAGEGPSSSYAQSIAPARTHEEMTPSLKTNAKYPNVHARTTSTDASYYMGMNSTYPESNMRTTRPVQTTQSTFPGMLPPGLPTSHMDTQPSAYNYSIPQATSDLQPGMDDANGMMIGSHEVDMNSINQQDSLPFVNGEILPWLEYLPQDVLSFFGDHQNYPLMSPDDVSRPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W6PPX9</accession>
    <name>W6PPX9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S01g000042</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PPX9"/>
    <dbReference type="STRING" id="1365484.W6PPX9"/>
    <dbReference type="OMA" id="THIRCTS"/>
    <dbReference type="OrthoDB" id="4273119at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM26233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="412" mass="46927" checksum="F46DBB7EBFBEDD3D" modified="2014-04-16" version="1">MSVNIRSERLAKYFGAVIHGKQEIQDSTHFKRFIEATLDQSDPSIVVQRIISSQSALKALQIGLRSNLTPVFINGYTAKLIQYLKNREVKLLCNGQFLEQLLLLIVEPRTLWGAFLEAFRTRKLEDHAIQALCWLMAELLSLPPSCGVDVSADAQTVLNDGSLFSSPSVDIRNSGHKIKYRLEMKTSAATYQHSEITAGGRHDNDFGDFRLTAIFPTADEMECKEKPFYRRAEDIAQMFSGQRIAGYIDNQFRLLREDMLSELRDEFQVARGTKKGRRSAFHLRNLFLTHIRCTSGTPSRLRPYTIGVTAQSGLGKLQNLSEDRRKEFLKTTPQFIKHRAFGCLVRDTEIVAFATIDRDIDELVSDPPTVMLRITGEEPLKKSLLYLKLYHDVEFLLVDTAIFAYEPILRCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>W6PR19</accession>
    <name>W6PR19_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Patatin-like phospholipase domain-containing protein</fullName>
            <ecNumber evidence="9">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PROQFM164_S01g000447</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Lipid hydrolase.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Probable lipid hydrolase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Membrane</location>
            <topology evidence="9">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the PLPL family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="9"/>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PR19"/>
    <dbReference type="STRING" id="1365484.W6PR19"/>
    <dbReference type="OMA" id="RACLMGE"/>
    <dbReference type="OrthoDB" id="10049244at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006641">
        <property type="term" value="P:triglyceride metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07230">
        <property type="entry name" value="Pat_TGL4-5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050301">
        <property type="entry name" value="NTE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021771">
        <property type="entry name" value="Triacylglycerol_lipase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226">
        <property type="entry name" value="NEUROPATHY TARGET ESTERASE/SWISS CHEESE D.MELANOGASTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226:SF10">
        <property type="entry name" value="TRIACYLGLYCEROL LIPASE 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11815">
        <property type="entry name" value="DUF3336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 8 9" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="6 8 9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="PNPLA" evidence="11">
        <location>
            <begin position="228"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="580"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="699"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="8">
        <location>
            <begin position="259"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="600"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="610"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="637"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="712"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="732"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="766"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8">
        <location>
            <position position="261"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDM26638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="789" mass="89384" checksum="2B2D387E4562968B" modified="2014-04-16" version="1">MHRPTMSVLGDPTLVQCHHGRKHSQEYSLPQPLPPRPLCKTISIPTVSSLVKDSWNWAGDTLHTYRDGLSKEQRKQRADIEDRKQVLYLKIKNAVSYEEWRSCASELDELEDNNAWKQTLECTEYDPRLVQDRLRQLEEARISCDVSRMLFLVRTALSRDLAHMSNASLYRHSHIGTKDLIDRYITTALDTIATLVDLSVHDRCDGLELKYILDQLLAARQAFGRSALLFSGGATFGMTHIGVLKALYEAKMIPRIISGASAGSIVCAVFCTRTDEELPALLDTYVHGDFDVFNEKGQEENILQKMTRFLKFGSFFDISHLAKTIRNWLGDMTFQEAYNRTRRILNICVSSAGMYELPRLLNYISAPNVLIWSAVAVSCSVPFVFRPFTLMAKDPLTGEPVPWNDLHKQYIDGSVDGDLPMTRLSEMFNVNHFIVSQVNPHVVPFLPKETGPQDATNDGPSFIPRWMNMMAHLAKDEVLHRMNVLSELGVFPTSMTKFASIVNQKYHGDINIYPELLSSNLPRLLENPTTEFMLSSCLSGERATWPRLSRIRNHCAIELALDNAIQNMRARVAFSPSQVDLRMPHRSRHSIDSADSNGRGRYRDRRRGSHSPEFEKRQSGGQELRRPDHELRKERSTVSLENPPLSQSSESIFMPTQTRTHRRTSSVFFSNGGIFDIGSSSDDELERSYMLRPKLAGHRTFSESSSFGRVAPSHGPRSPVRSRRSSLSSNPAYNFSSTARRSSPKQVYTPSARDFSVTIPPSSRHLLSMTPTPTLLPSSPEPLTRKRQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W6PRK7</accession>
    <name>W6PRK7_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Cytosine deaminase</fullName>
            <ecNumber evidence="14">3.5.4.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Cytosine aminohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">FCA1</name>
        <name evidence="18" type="ORF">PROQFM164_S01g000195</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the hydrolytic deamination of cytosine to uracil or 5-methylcytosine to thymine. Is involved in the pyrimidine salvage pathway, which allows the cell to utilize cytosine for pyrimidine nucleotide synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>cytosine + H2O + H(+) = uracil + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:20605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16040"/>
            <dbReference type="ChEBI" id="CHEBI:17568"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="13">Pyrimidine metabolism; UMP biosynthesis via salvage pathway; uracil from cytosine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cytidine and deoxycytidylate deaminase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.1" evidence="14"/>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PRK7"/>
    <dbReference type="STRING" id="1365484.W6PRK7"/>
    <dbReference type="OMA" id="MCTGACL"/>
    <dbReference type="OrthoDB" id="408702at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004131">
        <property type="term" value="F:cytosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008835">
        <property type="term" value="F:diaminohydroxyphosphoribosylaminopyrimidine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046087">
        <property type="term" value="P:cytidine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019858">
        <property type="term" value="P:cytosine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008655">
        <property type="term" value="P:pyrimidine-containing compound salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01285">
        <property type="entry name" value="nucleoside_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000016">
        <property type="entry name" value="Cytosine deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11079:SF190">
        <property type="entry name" value="CYTOSINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11079">
        <property type="entry name" value="CYTOSINE DEAMINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="17">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00050113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00056232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00060700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00066550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00074321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00084039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CDM26386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="148" mass="15896" checksum="F452A3EFBA696D5E" modified="2014-04-16" version="1">MEQDLGFIAAVEEAKQGLSEGGVPIGAALVSKDGKILGRGHNMRVQKGSAVLHAEMSALENSGRLPASAYEGATMYTTLSPCDMCTGACILYKVKRVVIGENKSFMGGEELLLNKGKEVVVLDNAECKELMTSFMKEKPELWNEDIAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W6PSJ1</accession>
    <name>W6PSJ1_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S01g000525</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PSJ1"/>
    <dbReference type="OMA" id="ADIFYWP"/>
    <dbReference type="OrthoDB" id="1894652at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39219">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39219:SF1">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21203">
        <property type="entry name" value="ECM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004881547" evidence="2">
        <location>
            <begin position="21"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM26716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="190" mass="20610" checksum="99A62CF696602133" modified="2014-04-16" version="1">MRFLSTIFSAVLLLISVANASFSTDILYWPLESPQPSVLASISYDPTSLKSDVVSYHPPKDDQRDNLVRVGLYTSTSPNKKQWVGSLVSLSSLTASEQPTFRLHLGPTNEVYTVSLSASTSAQGSTSSPQIELVSNESGTQPHLNRPVIVGPDGQNPEQPEEKSILQKYWWVIPILMFLSMSAGGGGEGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>W6PST9</accession>
    <name>W6PST9_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nonribosomal peptide synthetase sidC</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Siderophore peptide synthetase C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PROQFM164_S01g000749</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM164</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Siderophore biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the NRP synthetase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1365484.W6PST9"/>
    <dbReference type="OMA" id="CTMLPRM"/>
    <dbReference type="OrthoDB" id="416786at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043041">
        <property type="term" value="P:amino acid activation for nonribosomal peptide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010106">
        <property type="term" value="P:cellular response to iron ion starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031169">
        <property type="term" value="P:ferrichrome biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05918">
        <property type="entry name" value="A_NRPS_SidN3_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd19542">
        <property type="entry name" value="CT_NRPS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.980:FF:000001">
        <property type="entry name" value="Non-ribosomal peptide synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000033">
        <property type="entry name" value="Nonribosomal siderophore peptide synthase SidC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000024">
        <property type="entry name" value="Nonribosomal siderophore peptide synthase SidC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527:SF1">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Carrier" evidence="10">
        <location>
            <begin position="699"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="10">
        <location>
            <begin position="1757"/>
            <end position="1834"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="10">
        <location>
            <begin position="2319"/>
            <end position="2392"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="10">
        <location>
            <begin position="3374"/>
            <end position="3451"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="10">
        <location>
            <begin position="3948"/>
            <end position="4021"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="10">
        <location>
            <begin position="4500"/>
            <end position="4573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="3916"/>
            <end position="3936"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00067294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00078302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDM26940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="5075" mass="560613" checksum="6F924E7A1AD5D51C" modified="2014-04-16" version="1">[encoded data, 5075 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W6PTK0</accession>
    <name>W6PTK0_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Putative lipase ATG15</fullName>
            <ecNumber evidence="6">3.1.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">Autophagy-related protein 15</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Putative lipase atg15</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="primary">atg15</name>
        <name evidence="24" type="ORF">PROQFM164_S01g001344</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="19">Lipase which is essential for lysis of subvacuolar cytoplasm to vacuole targeted bodies and intravacuolar autophagic bodies. Involved in the lysis of intravacuolar multivesicular body (MVB) vesicles. The intravacuolar membrane disintegration by ATG15 is critical to life span extension.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12044"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17855"/>
            <dbReference type="ChEBI" id="CHEBI:18035"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="EC" id="3.1.1.3"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Binds to both phosphatidylinositol (PI) and phosphatidylinositol 3,5-bisphosphate (PIP2).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endosome</location>
            <location evidence="3">Multivesicular body membrane</location>
            <topology evidence="3">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Prevacuolar compartment membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.3" evidence="6"/>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PTK0"/>
    <dbReference type="STRING" id="1365484.W6PTK0"/>
    <dbReference type="OMA" id="TYHFGHT"/>
    <dbReference type="OrthoDB" id="58570at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032585">
        <property type="term" value="C:multivesicular body membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005775">
        <property type="term" value="C:vacuolar lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004620">
        <property type="term" value="F:phospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034496">
        <property type="term" value="P:multivesicular body membrane disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046461">
        <property type="term" value="P:neutral lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006660">
        <property type="term" value="P:phosphatidylserine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000129">
        <property type="entry name" value="Autophagy related lipase Atg15, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050805">
        <property type="entry name" value="ATG15_Lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47175">
        <property type="entry name" value="LIPASE ATG15-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47175:SF2">
        <property type="entry name" value="LIPASE ATG15-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0072">Autophagy</keyword>
    <keyword evidence="10" id="KW-0967">Endosome</keyword>
    <keyword evidence="18" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="16" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="17" id="KW-0472">Membrane</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="22" id="KW-0732">Signal</keyword>
    <keyword evidence="13" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="22">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004879184" description="Putative lipase ATG15" evidence="22">
        <location>
            <begin position="31"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="domain" description="Fungal lipase-type" evidence="23">
        <location>
            <begin position="291"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="560"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="560"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="585"/>
            <end position="598"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00018542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00019241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00024663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00029828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="CDM27533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="598" mass="64292" checksum="27E8EA0C67793321" modified="2014-04-16" version="1">MARKCSRFEISIRSLLFAAAVLSGAASASGYHLPSPQVPVIPLNGDEGTPDTHEFSLRHIFHRGTYEQPDFHARLDVKPDTRLRTISEDGHEEEYIASDSTLLASSSPLTIQRLADRRLQVIQGHLAAARSSGFATALSPLEWVMDTLPGPNITDKQTVLTFAQMTANDYIEEPGTGEWHTINGKFNYSGSFGWQTDGLRGHIYSDKTNDTVVISLKGTSPALFDGAGTTTNDKVNDNLFFSCCCGQGGSYLWRQSCDCQSATFTANLTCIVESMNDENRYYRAAIDLYSNVTEIYPDANIWMTGHSLGGAMTSLVGLTFGLPVVTFEAVPEALPAARLGLPSPPGYDPRFPQSRQFTGSYHFGHTADPIYMGTCNGINSICTWGGYAMESACHTGQMCTYDTVADKGWRVGLGTHKIENVISDVILKYDNVPSCVAEEECFDCELWKFFRSNGSDVTTTTTTTTTASPTRTSTCKTPGWWGCLDESTTATTTTTTSPTSTATTTTCKTPGWFGCKDPTTTAIPSPTVTTTLPSVTATTSCHDPGWFGCRDGTSTVATTTATSASPSSSTCDSLGNMSGCRDESTNSPAITLAPTPTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W6PTK2</accession>
    <name>W6PTK2_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g000905</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PTK2"/>
    <dbReference type="OrthoDB" id="4367615at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM27096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="259" mass="29073" checksum="7CE89B629649F25F" modified="2014-04-16" version="1">MPPKPSTRKGVKKEMPKTEPSTGTHSPKIKAEVSSPTPAFFANDGNEKSPAIPANDTTNLNTRNTKKSSPLSVKMEDIPEANPRIQRPSNPVSSTFSDNLGHLIFTRGVPDSDDDISSVPSLVENIAEQARTAKHVGFFMNTSHNKHFIPIEVPSLLGNENWEYWLAAMLLLFRQHSVWPIVTAELQPLSPSHNLYLWYQRMRDCAIELIYANVSEEVRKTPCFISTVHDDDPNVLMRHLYAHYASPDSDHSDDESELD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W6PTX6</accession>
    <name>W6PTX6_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S01g001114</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PTX6"/>
    <dbReference type="STRING" id="1365484.W6PTX6"/>
    <dbReference type="OrthoDB" id="10253390at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021829">
        <property type="entry name" value="DUF3419"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47473">
        <property type="entry name" value="BTA1P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47473:SF1">
        <property type="entry name" value="METHYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11899">
        <property type="entry name" value="DUF3419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM27305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="194" mass="22199" checksum="263CDF0F800B266B" modified="2014-04-16" version="1">MMTCPFQQWISFIFGCRAAFRDFLATKTLNEQRGIWPNRIRPALLSKLVCKLVVSQESFLWAALGVPKNQLAMIESEAVSGPNPTDRKTRSHAIWKYMVDTFDPVADQTHIGADNPSYQVCMTGAFTRRCHPDYLPRKAHAKLSSPGALDGLRIHTDDVNEVLNYITPDTDRRRCHGQHRLVRPERRSRSLSEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W6PU07</accession>
    <name>W6PU07_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 14">Inositol oxygenase</fullName>
            <ecNumber evidence="4 14">1.13.99.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 14">Myo-inositol oxygenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">MIOX1</name>
        <name evidence="15" type="ORF">PROQFM164_S01g001509</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11 14">
            <text>myo-inositol + O2 = D-glucuronate + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23696"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
            <dbReference type="ChEBI" id="CHEBI:58720"/>
            <dbReference type="EC" id="1.13.99.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13 14">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="13 14">Binds 2 iron ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Polyol metabolism; myo-inositol degradation into D-glucuronate; D-glucuronate from myo-inositol: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the myo-inositol oxygenase family.</text>
    </comment>
    <dbReference type="EC" id="1.13.99.1" evidence="4 14"/>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PU07"/>
    <dbReference type="STRING" id="1365484.W6PU07"/>
    <dbReference type="OMA" id="RYNTKYG"/>
    <dbReference type="OrthoDB" id="5151075at2759"/>
    <dbReference type="UniPathway" id="UPA00111">
        <property type="reaction ID" value="UER00527"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050113">
        <property type="term" value="F:inositol oxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019310">
        <property type="term" value="P:inositol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3210.10">
        <property type="entry name" value="Hypothetical protein af1432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007828">
        <property type="entry name" value="Inositol_oxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12588:SF0">
        <property type="entry name" value="INOSITOL OXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12588">
        <property type="entry name" value="MYOINOSITOL OXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05153">
        <property type="entry name" value="MIOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="7 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="12">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="123"/>
            <end position="125"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="179"/>
            <end position="180"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="257"/>
            <end position="258"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR607828-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR607828-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU367039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CDM27698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="323" mass="37607" checksum="E51BBBD0FE009CC2" modified="2014-04-16" version="1">MAPVAISPQASPVFKKRDGHALEELSDAIDEINVLKDMKKREAEKKVAEEKGLYDESEFDKEKDKTNFRQYEDASDRVKNFYKEQHTKQTVAYNLKARHDFHSKTRAEMTVWEAMEKLNTLIDESDPDTSLSQIDHLLQSAEAIRRDGKPRWMQLTGLIHDLGKLLFFFDAEGQWDVVGDTFPVGCGFDDKIVYGRDSFRDNEDFGHKIYDTKFGIYTPGCGLDNVMLSWGHDEYLYHLAKEQSTLPDEALAMIRYHSFYPWHSAGAYHELMNEHDRDMLRAVKAFNPYDLYSKSDGIPSVEELKPYYLELIDEYFPTKVLKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>W6PU27</accession>
    <name>W6PU27_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="23">Phospholipid-transporting ATPase</fullName>
            <ecNumber evidence="23">7.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="27" type="primary">DNF2</name>
        <name evidence="27" type="ORF">PROQFM164_S01g001055</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="27" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.</text>
            <dbReference type="EC" id="7.6.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-L-serine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38567"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:38568"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phosphocholine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38583"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:38584"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66132"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:66133"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>a beta-D-glucosyl-(1&lt;-&gt;1')-N-acylsphing-4-enine(out) + ATP + H2O = a beta-D-glucosyl-(1&lt;-&gt;1')-N-acylsphing-4-enine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66036"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:22801"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:66037"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 22">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="23">Membrane</location>
            <topology evidence="23">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 23">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.1" evidence="23"/>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1365484.W6PU27"/>
    <dbReference type="OMA" id="QALRCGR"/>
    <dbReference type="OrthoDB" id="377733at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070867">
        <property type="term" value="C:mating projection tip membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990531">
        <property type="term" value="C:phospholipid-translocating ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140351">
        <property type="term" value="F:glycosylceramide flippase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090554">
        <property type="term" value="F:phosphatidylcholine floppase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140346">
        <property type="term" value="F:phosphatidylserine flippase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090556">
        <property type="term" value="F:phosphatidylserine floppase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099040">
        <property type="term" value="P:ceramide translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007163">
        <property type="term" value="P:establishment or maintenance of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02073">
        <property type="entry name" value="P-type_ATPase_APLT_Dnf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000048">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000108">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000001">
        <property type="entry name" value="Phospholipid-transporting ATPase IC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006539">
        <property type="entry name" value="P-type_ATPase_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032631">
        <property type="entry name" value="P-type_ATPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032630">
        <property type="entry name" value="P_typ_ATPase_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01652">
        <property type="entry name" value="ATPase-Plipid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092:SF180">
        <property type="entry name" value="PHOSPHOLIPID-TRANSPORTING ATPASE DNF1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092">
        <property type="entry name" value="PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16212">
        <property type="entry name" value="PhoLip_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16209">
        <property type="entry name" value="PhoLip_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 21 23" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="10 22 23" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14 23" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 22" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 21 23" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 23" id="KW-1278">Translocase</keyword>
    <keyword evidence="6 23" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 23" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="144"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="514"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="557"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="1133"/>
            <end position="1149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="1161"/>
            <end position="1182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="1212"/>
            <end position="1233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="1253"/>
            <end position="1271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="1278"/>
            <end position="1298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="1318"/>
            <end position="1338"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase N-terminal" evidence="25">
        <location>
            <begin position="114"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase C-terminal" evidence="26">
        <location>
            <begin position="1098"/>
            <end position="1347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="248"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="274"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="1369"/>
            <end position="1513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="24">
        <location>
            <begin position="56"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="24">
        <location>
            <begin position="75"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="24">
        <location>
            <begin position="307"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="24">
        <location>
            <begin position="1420"/>
            <end position="1440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="24">
        <location>
            <begin position="1442"/>
            <end position="1470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="24">
        <location>
            <begin position="1495"/>
            <end position="1513"/>
        </location>
    </feature>
    <feature type="active site" description="4-aspartylphosphate intermediate" evidence="20">
        <location>
            <position position="628"/>
        </location>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="628"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="628"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="629"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="630"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="630"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="762"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="803"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="826"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="861"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="941"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="942"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="943"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="1046"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="1052"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="1072"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="1075"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="1076"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="1076"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00034036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00050913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00051303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00052223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="RuleBase" id="RU362033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="Pfam" id="PF16209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="Pfam" id="PF16212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="EMBL" id="CDM27246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="1513" mass="170471" checksum="2EE5E23C7FD376A4" modified="2014-04-16" version="1">MASARFPGDNGEDEGDNNEQGADIGEVNSHVSKPTKRQRWATTRAPGHGGVKKRVSIIDRFHKRSDLKDEKRKSNNTSTSGNSESQIPQEGPNRRIYFSIPIPESERDEDGHLRITYPRNKIRTAKYTPLTFVPYNIWLQFHNIANIYFLFVIILNCFPIFGANNPGLNAVPLIVIIVVTAIKDAIEDWGRTVSDNQVNNSPVYRLVEWNNVNSTEDNIDIWRRVKKACTRGSIASYKWVVSQFKKKEKEGDDDEGQRRDSFLSTADRRSSIYTQRNSLAPEDIAIPMTDVPSPQPEAREDWPIVSNPENKYLSPNSAARQSVVEPTPDKKHGTILDMSKQTPGKARFKREQWKSLQVGDFVRLYNEDPIPADVVILSTSDPDGACYVETKGLDGETNLKVRQALHCGHEVRHARDCEKAEFVIESEAPHANLYTYNGAIRWDQRDPRFPEAPRKEMVEPISINNILLRGCNLKSTEWVLGVVLFTGGESKIMLNSGATPAKRPRMAKDLNWNVIYNFFILFLMCIVAGIVNGIAWARPDKSLDYFDLESYGGTPPVTGIVTFWTALILFQNLVPISLYISLEIVRTIQALFINNDLFMYYERLGIYCVPKSWNISDDVGQVEYIFSDKTGTLTQNLMEFKKCTVNGLAYGEAYTEAQVGMRRREGADADAEAAVARQQIAADAQKMLGLLRGIHDNPYLHDDQLTFVAPNFVADLTGQSGERQKHCTEDFMLALALCHTVITEHTPGDPPQIEFKAQSPDEAALVSTARDCGFTVLGRAGDDLLLNVMGEERTYTVLNTLEFNSSRKRMSAIIRMPDGTIRLFCKGADSIIYSRLARGKQQELRRQTAEHLEEFAREGLRTLCVADRLLSEDEYYTWAKEHDIAAAAITDREEKLEMVSSQIEQELMLIGGTAIEDRLQDGVPDTIQLLADAGIKLWVLTGDKVETAINIGFSCNLLNNNMELIVLNIPETEHQQASDELDKNLQNFGLTGSDEELIAARADHTPPEATHAVVVDGETLKLMLSDDLKQKFLLLCKQCKAVLCCRVSPAQKAAVVNMVKNGLNIMALSVGDGANDVAMIQEADVGVGIAGEEGRQAVMSSDYAIGQFRYLQRLLLVHGRWSYRRLGECTANFFYKNLVWTFALFWYCIYNDFDCSYLFDYTYIILVNLAFTSLPVIFMGIFDQDVDDKVSLAVPQLYMRGIERKEWSQLKFWLYMADGMYQSIICFFMPYLLFAPANFVNETGRNINDRARIGVLVASCAVIASNIYIMMNTYRWDWFTSLINAISSILIFVWTGIYTSFTSSGQFYHSAAEVYGSLSYWVVLLMTVVVCLLPRFTYNSIQKVFFPLDVDIIREQVTMGKFKYLDAIEDPPMPPKEGGPKAVAPSDESATSSEIVKPVQPAIKQDTDEERPFYAASVAPTANTHNPRSQNSSNGTNYTASLDHDPRPQSVDYVRRSPDRTRHSFDRSRPSFEQSNDFTSAAMLSRVESSQTPHRQHEDPFRTADDPPVHNVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W6PUS9</accession>
    <name>W6PUS9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxoglutarate/iron-dependent dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g001342</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PUS9"/>
    <dbReference type="STRING" id="1365484.W6PUS9"/>
    <dbReference type="OMA" id="IAMFCAP"/>
    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM27531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="278" mass="30567" checksum="D9B47F09C1B005C8" modified="2014-04-16" version="1">MSAKLPRINLNKPVSSTLASDLKLALRRFGAFRLVVAPETRQHCPDVAREFFTQPITAKTDIKGYSPFASERVRGRAEIPKESIYFFRHGAEPNHLKGPSCNLYRSVKSLHEGWTPIRLQLLKTISQALDSDTSLTGTTLLDSATIGIHYYDSRSLPDFSAHFSPPHMDSGTLTILFRSHNENDGLEIADLETTEKQDSEGVGSEASFMHVPTFGDDAPEVVVFAGTRLQRLLGRDRVRACVHRVRGPGPEAHNNSGVQRLSIAMFCAPSGPSTSPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W6PV08</accession>
    <name>W6PV08_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g001536</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PV08"/>
    <dbReference type="STRING" id="1365484.W6PV08"/>
    <dbReference type="OMA" id="RYHPIAM"/>
    <dbReference type="OrthoDB" id="5431097at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="330"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="388"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="336"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="407"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="443"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="456"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM27725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="471" mass="52186" checksum="8A2E9FBE4F0CCDB9" modified="2014-04-16" version="1">MTTAPPVHHSGPDSGIPGHLVNHLPRYHPIAMNPNPPPHQMPPPEQMVQSHHFRHFAPPMHEHHPQGIPPIHSPASLEHIEARLRHLEHEEMVRNATRSRVLAMRKHEDEEFRSMTERAEAEEEDLRRQRKKLKRESMGLGLNAAGDSPPLRPTPPRRLSETSAATTLAFFKQQTPPEPRQEPLPSSSQAPPPSMPPPHMHAQPHHQAPPPPPPSQHQHPMLPHDSIQIHSAGSIRRKQKYTIKNVEAWGERHGRPAAHDPSGRALWKRPSDGSLVYLTCPIHGCGKSDFVTLHGFMCHLTKKHKDRTLGSQSRALEVCGVVYDPNAPLPPVMNNHRASTEGSPLGSNPLDPDGDQHYEDMDSESEGELEREGSYRVKTEVLDRFMPDAEGTPIEPAAATPPKHAANGSTKQSISSIIDRTPETESREALATLPPSESGIQGPSPTSTESSVPSKRKYEFSPPAEKENAEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W6PV28</accession>
    <name>W6PV28_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="5">A1 cistron-splicing factor, AAR2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PROQFM164_S01g001462</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAR2 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PV28"/>
    <dbReference type="STRING" id="1365484.W6PV28"/>
    <dbReference type="OMA" id="VWQSGGL"/>
    <dbReference type="OrthoDB" id="201752at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000244">
        <property type="term" value="P:spliceosomal tri-snRNP complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13778">
        <property type="entry name" value="Aar2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13777">
        <property type="entry name" value="Aar2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.550">
        <property type="entry name" value="Aar2, C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007946">
        <property type="entry name" value="AAR2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033648">
        <property type="entry name" value="AAR2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038514">
        <property type="entry name" value="AAR2_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033647">
        <property type="entry name" value="Aar2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038516">
        <property type="entry name" value="AAR2_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12689">
        <property type="entry name" value="A1 CISTRON SPLICING FACTOR AAR2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12689:SF4">
        <property type="entry name" value="PROTEIN AAR2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05282">
        <property type="entry name" value="AAR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20981">
        <property type="entry name" value="AAR2_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAR2 N-terminal" evidence="4">
        <location>
            <begin position="7"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="AAR2 C-terminal" evidence="3">
        <location>
            <begin position="258"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="153"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="233"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF20981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDM27651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="464" mass="51760" checksum="A955AC3D26E961A4" modified="2014-04-16" version="1">MSTHHPTPTILLPGLPPKTLVGIDLITFTSTPNFHGIRDLSPGWHFLYTGATETLSLRSGAWFYIGDITTAGKGSNDTALVAQGHKNQTQNASEPEIYIWKWSVNTESLVALDGESASSLQESMRYKANLGSVWQSGGLFKYRSRIAPSMLVKPVTESDTGEKNEQDQPEHQIEARIQTEDDSQTEESGRRDWSGLTDRISPSLLSRVIGKPEVDVDGHPRWALSSASTANCDADHIPGVDSPAEGSHEPEPEREFGFIPVDLKRTWREGAVGRERTEAAKDRSWALGDLIDRYAGEASGGNQLLGELQFTFLMVLTMMNYSCLQQWKRLLELILTSRGAILDREAFMSEVLRILSLQLQRCDDVDGGLFEIDGDEGGAFLRDLLMKLRQSVDDLVGDSGSEVKLELDKLEEWVRAEYNWELRRGTVVRHGMLQLEDGEQVEMDWDGNDEDDETGEYAPVIVDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W6PWP0</accession>
    <name>W6PWP0_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">precorrin-2 dehydrogenase</fullName>
            <ecNumber evidence="2">1.3.1.76</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">met8</name>
        <name evidence="9" type="ORF">PROQFM164_S01g002027</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>precorrin-2 + NAD(+) = sirohydrochlorin + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:15613"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58351"/>
            <dbReference type="ChEBI" id="CHEBI:58827"/>
            <dbReference type="EC" id="1.3.1.76"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Porphyrin-containing compound metabolism; siroheme biosynthesis; sirohydrochlorin from precorrin-2: step 1/1.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.76" evidence="2"/>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PWP0"/>
    <dbReference type="STRING" id="1365484.W6PWP0"/>
    <dbReference type="OMA" id="TQIWKLC"/>
    <dbReference type="OrthoDB" id="1721126at2759"/>
    <dbReference type="UniPathway" id="UPA00262">
        <property type="reaction ID" value="UER00222"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004325">
        <property type="term" value="F:ferrochelatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043115">
        <property type="term" value="F:precorrin-2 dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019354">
        <property type="term" value="P:siroheme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.110">
        <property type="entry name" value="Siroheme synthase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3280.10">
        <property type="entry name" value="Siroheme synthase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028161">
        <property type="entry name" value="Met8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028162">
        <property type="entry name" value="Met8_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028281">
        <property type="entry name" value="Sirohaem_synthase_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006367">
        <property type="entry name" value="Sirohaem_synthase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01470">
        <property type="entry name" value="cysG_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35330">
        <property type="entry name" value="SIROHEME BIOSYNTHESIS PROTEIN MET8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35330:SF1">
        <property type="entry name" value="SIROHEME BIOSYNTHESIS PROTEIN MET8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13241">
        <property type="entry name" value="NAD_binding_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14823">
        <property type="entry name" value="Sirohm_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14824">
        <property type="entry name" value="Sirohm_synth_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75615">
        <property type="entry name" value="Siroheme synthase middle domains-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Siroheme synthase central" evidence="8">
        <location>
            <begin position="130"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="Siroheme biosynthesis protein Met8 C-terminal" evidence="7">
        <location>
            <begin position="159"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF14824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM28216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="234" mass="25591" checksum="0EB2236AD18D2BB9" modified="2014-04-16" version="1">MSKFPEVQGGGSLILAWQIKNKHVLVVGGGEVAAGRILNVLNADARVTVVCPAAGLNEEVAFRVAEKQVTHVDRNFEPSDLDNVDMVLCAIDDPEASTQVWKLCKERRIAANIADVPPECDFYFGSIHRDGPLQIMVSTNGNGPKLASIVRKKIAETLPANTGAAIENVGKLRRKLREIAPNPDQGPKRMKWMSGVCETWSLDELVGMTEKDMDGVLSFYEPGKIPTLEEVQNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W6PXW6</accession>
    <name>W6PXW6_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial</fullName>
            <ecNumber evidence="10">6.2.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Succinyl-CoA synthetase beta chain</fullName>
            <shortName evidence="10">SCS-beta</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PROQFM164_S01g000623</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>succinate + ATP + CoA = succinyl-CoA + ADP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17661"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.2.1.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="10">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Heterodimer of an alpha and a beta subunit. The beta subunit determines specificity for GTP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10 12">Belongs to the succinate/malate CoA ligase beta subunit family.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.5" evidence="10"/>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PXW6"/>
    <dbReference type="STRING" id="1365484.W6PXW6"/>
    <dbReference type="OMA" id="ITACDEV"/>
    <dbReference type="OrthoDB" id="1552at2759"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00999"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042709">
        <property type="term" value="C:succinate-CoA ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004775">
        <property type="term" value="F:succinate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006104">
        <property type="term" value="P:succinyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000002">
        <property type="entry name" value="Succinate--CoA ligase [ADP-forming] subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.261:FF:000001">
        <property type="entry name" value="Succinate--CoA ligase [ADP-forming] subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000004">
        <property type="entry name" value="Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00558">
        <property type="entry name" value="Succ_CoA_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013650">
        <property type="entry name" value="ATP-grasp_succ-CoA_synth-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017866">
        <property type="entry name" value="Succ-CoA_synthase_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="SUCC_ACL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005809">
        <property type="entry name" value="Succ_CoA_ligase-like_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001913">
        <property type="entry name" value="PRK00696.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01016">
        <property type="entry name" value="sucCoAbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11815:SF1">
        <property type="entry name" value="SUCCINATE--COA LIGASE [ADP-FORMING] SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11815">
        <property type="entry name" value="SUCCINYL-COA SYNTHETASE BETA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08442">
        <property type="entry name" value="ATP-grasp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001554">
        <property type="entry name" value="SucCS_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01217">
        <property type="entry name" value="SUCCINYL_COA_LIG_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="2 10" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="ATP-grasp" evidence="13">
        <location>
            <begin position="41"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="85"/>
            <end position="87"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="303"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared with subunit alpha</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="360"/>
            <end position="362"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared with subunit alpha</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00063570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDM26814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="443" mass="47611" checksum="3BB709016B757110" modified="2014-04-16" version="1">MFKLARGRPVAAAFKAATQPSIQSRIALQKRNLSIHEYRSASLLKTYGVGVPRGEVANTPEEAEAIAKSIGGGDLVIKAQVLAGGRGKGQFDNGLKGGVRVIYSPTEAKMFAGQMIGHKLVTKQTGAGGRICNSVYICERKFARREFYVAVLLDRTTRGPVIVSSSQGGMDIEAVAKESPDAITSTPIDIHVGVTDEIARTIATDLGFSEQCIEDAKNTIQNLYKCFMERDVTQLEINPLSETSDHQVLAMDAKLGFDDNAEFRQKEVFSWRDVSQEDADEVKAAEHGLNFIKLDGDIGCLVNGAGLAMATMDIIKLNGGTPANFLDVGGGATPAAIKSAFELITSDPKVSAVFVNIFGGIVRCDAIAQGLINVVQEMNITTPIIARLQGTNMEKAHELINESGLKIFSIEDLQNAAEKSVQFSKVVKMAREIDVGVEFTLGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W6PYM2</accession>
    <name>W6PYM2_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 13">Cytochrome c oxidase subunit 6, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12 13">Cytochrome c oxidase polypeptide VI</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">cox-6</name>
        <name evidence="14" type="ORF">PROQFM164_S01g003180</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of a catalytic core of 3 subunits and several supernumerary subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Mitochondrion inner membrane</location>
            <topology evidence="1 13">Peripheral membrane protein</topology>
            <orientation evidence="1 13">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the cytochrome c oxidase subunit 5A family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PYM2"/>
    <dbReference type="STRING" id="1365484.W6PYM2"/>
    <dbReference type="OMA" id="MEKWPAD"/>
    <dbReference type="OrthoDB" id="5778907at2759"/>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045277">
        <property type="term" value="C:respiratory chain complex IV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00923">
        <property type="entry name" value="Cyt_c_Oxidase_Va"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.40:FF:000001">
        <property type="entry name" value="Cytochrome c oxidase subunit VI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.40">
        <property type="entry name" value="Cytochrome c oxidase, subunit Va/VI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003204">
        <property type="entry name" value="Cyt_c_oxidase_su5A/6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036545">
        <property type="entry name" value="Cyt_c_oxidase_su5A/6_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14200">
        <property type="entry name" value="CYTOCHROME C OXIDASE POLYPEPTIDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14200:SF11">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 5A, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02284">
        <property type="entry name" value="COX5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48479">
        <property type="entry name" value="Cytochrome c oxidase subunit E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 13" id="KW-0349">Heme</keyword>
    <keyword evidence="8 13" id="KW-0408">Iron</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 13" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00070174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00082700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU368103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDM29368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="158" mass="17770" checksum="EED8B6F1D07A7B53" modified="2014-04-16" version="1">MSSLSIFRVATRAARSTGSFRAPQLTRSRMQSPVTLAAARAHNFGTTSMLRSGHEDETYEEFTARFEKEFDGVQDVFELQRNLNNCFAYDLVPSVAVLTAALKAARRVNDFPTAVRVFEGVKAKVENPDQYKQYLESLEGLRVELGVALREELYPEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W6PYN8</accession>
    <name>W6PYN8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aldolase-type TIM barrel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g003195</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PYN8"/>
    <dbReference type="OMA" id="IWGGKNH"/>
    <dbReference type="OrthoDB" id="4139606at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004879263" evidence="1">
        <location>
            <begin position="20"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM29383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="272" mass="30037" checksum="3E8CFAE418EA2257" modified="2014-04-16" version="1">MKTLFQHTVGLALACSTYASSFHVFDNTAYVNTSIGYGTTNINWIPAYVCNPLTEGGVLPSADVWKDIVLEWNIYPSYPLVLDCEDLYFTDASTADLHLELMSTLQTWAADVIPSGQIIGWYGLSGNTISSLYDHYRSLIANHTSHAFFPSAYTFSDSLSTWNASLTSVLKTINAIDDSLPVWPYTWPQYHGNYSFIPSTLWEDELNALAKNSNVDGFVIWGGKNHAVCNDACQSTAGQQPWLNATRTYLNTLYGIYSGDAEVEGSQIFGGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2024-10-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>W6PYS1</accession>
    <name>W6PYS1_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S01g002982</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PYS1"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM29170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="60" mass="6920" checksum="030F6A03061BF96A" modified="2014-04-16" version="1">MTQSFQKPDHTRSCGERFTIRSSRAAQSNNLLELGVWRFVSLVDGTRHGWRSSRPDNTQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>W6PZ34</accession>
    <name>W6PZ34_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 14">DNA replication licensing factor MCM6</fullName>
            <ecNumber evidence="3 14">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">MCM6</name>
        <name evidence="17" type="ORF">PROQFM164_S01g003077</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="14">Component of the MCM2-7 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the MCM family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3 14"/>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PZ34"/>
    <dbReference type="STRING" id="1365484.W6PZ34"/>
    <dbReference type="OMA" id="RHQQTDK"/>
    <dbReference type="OrthoDB" id="1744952at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097373">
        <property type="term" value="C:MCM core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990518">
        <property type="term" value="F:single-stranded 3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902969">
        <property type="term" value="P:mitotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006279">
        <property type="term" value="P:premeiotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17757">
        <property type="entry name" value="MCM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.870:FF:000002">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.10:FF:000003">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1640.10:FF:000009">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000115">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.870">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.10">
        <property type="entry name" value="mini-chromosome maintenance (MCM) complex, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008049">
        <property type="entry name" value="MCM6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041024">
        <property type="entry name" value="Mcm6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF43">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18263">
        <property type="entry name" value="WHD_MCM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01662">
        <property type="entry name" value="MCMPROTEIN6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11 14" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4 14" id="KW-0235">DNA replication</keyword>
    <keyword evidence="9 13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 14" id="KW-0347">Helicase</keyword>
    <keyword evidence="6 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="16">
        <location>
            <begin position="477"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="797"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="25"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="811"/>
            <end position="824"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00073495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU368064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CDM29265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="953" mass="105484" checksum="3E995A71057CFDCB" modified="2014-04-16" version="1">MSSLFDAVIQSELGSAPSRDRNLRSDNLPSSRRSESNGPMSDMNAFPDDQVVGAGSSAISRMRNPYAPAAPPVVDEAAEKVQQAFEELLESYIDEPSSSAPPSSGEFLSDKYYIAQIKGMKKFELSTLYVDFTHIHNPVLADAIASQYYRFQPFLTKGLHNLIAKYEPEYFVSHRMTASASSRASTSVASAYAGVSDNPDLERQIREKTRHQQTDKMFALAFYNLPLVSRLRQLRTNQIGKLLSVSGTVTRTSEVRPELSLGTFICEGCKTVVPNVEQTFKYTEPMDCPNKTCGNRVGWRLDIGKSTFVDWQKVKLQESSHEIPTGSMPRTMDVILRGEMVDRAKAGERCVFTGTLIVVPDVSQLGLPGVRPEAVRDNNSFRGNEVGGSGVSGLKSLGVRDLTYRLAFLSCMVTPDTTTPGQKPEQQLSGQSNNILASLNQNQEDDLGDESAQEAFLHSLTSAEVQDLKGLVHSDYIYSRLVDSIAPMIWGHRQIKKGLLLQLIGGVGKSTSIESMKLRGDINICIVGDPSTSKSQFLKYVCSLHPRAVYTSGKASTAAGLTASVVKDPETGEFTIEAGALMLANGGGICAIDEFDKMDIADQVAIHEAMEQQTISIAKAGIHTTLNARASILAAANPVNGRYDPKQTLRNNLNFSAPIMSRFDVFFVIRDDPKESVDRSLANHIVNVHMYRDEAVEPELSTEQLQRYIRFARTFRPVFTEEAKTLLVEKYKELRSNDAQGGVGRSSYRITVRQLESLIRLSEAVAKANCVEEVVPKFVIEAYDLLRQSIVTVEKDDVEIEDDVPTHTNDGDEDQDMADGDNDGDSPMRDVAEPAQAAAQPERQKTKITYDKYAKILNQIVRRVHEDEVNSGEGVEQEDLVLWYLEQIEGELNTKEDYERERELAGKVLKRMVKDKLLLRISGSGLTDGTDDDAQNDGKVLFVMHPDCAFEEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W6PZT1</accession>
    <name>W6PZT1_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PROQFM164_S01g001280</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PZT1"/>
    <dbReference type="STRING" id="1365484.W6PZT1"/>
    <dbReference type="OMA" id="AGYVWIY"/>
    <dbReference type="OrthoDB" id="2585655at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000318">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF177">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="153"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="182"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="212"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="241"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="310"/>
            <end position="328"/>
        </location>
    </feature>
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        <location>
            <begin position="348"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="390"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="421"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="456"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="488"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="87"/>
            <end position="511"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CDM27469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="517" mass="57207" checksum="A23793EE40D251AC" modified="2014-04-16" version="1">MPSFELQPSSSRRDELEEVPGTKADIDLIESAGNGHAVTSVESMVARLPKAHRDYLMERHGTLELDPIPGMSPADPYNWPEWKKMTNLVLVAFHACMGTFTAAGIIPAFLDISTELGVGMQDASYLTSLQIAILGGAPLFWKPLSNRYGRRPIFLLSLICSLVCNIGCAKSTTYASLAACRALVAFFISPASAIGSAVVMETTFKKDRGRYMGVWTLLVTLGVPVGPFIFGFVTYRVGYHWIFWILAIINGCQFILYLFLGPETRYLGGGIDSKESTMKIEYMSLRRIDPTPFSWFEFIRPLTMARHPSILIPACAYAMVFLFGNILATVEIPQLLQEKFELNAEQLGMQFLGAIIGSVIGEQMGGVLSDFWMSRRSRRINRKAEPEFRLWLSYFGFALTIIGIIVFLVCTQESPSGHWNVTPIIGTAIGAVGNQLVTTVMITYAIDCFPQEAGNIGVFITFVRQIWGFLGPFWFAPMFETVGIAPSAGIGSALVVCVSVIPTIFLQWRGKGWRSEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q018</accession>
    <name>W6Q018_PENRF</name>
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        <submittedName>
            <fullName evidence="9">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
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    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
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        <lineage>
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            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
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        <property type="protein sequence ID" value="CDM29286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF64">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="19"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="75"/>
        </location>
    </feature>
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            <end position="153"/>
        </location>
    </feature>
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            <end position="197"/>
        </location>
    </feature>
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            <end position="269"/>
        </location>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CDM29286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="362" mass="39883" checksum="96B65E3C09182AF2" modified="2014-04-16" version="1">MGWVYNLHETDPNSEIPRVIGICLACSITAFLAVCLRFYVRIRISRFPWIDDYAALAGSLLTLAYAGIAVAQTRWGQGLSAAYFPKENVIPFSRIQYAGGPTYCLAVLGFKVALLASYLRIAGIIERYRKIIIATIVVCVVNQLIFAFIISISCIPVAKQWDTSLKGHCIQTIPFYFALGGTSIVLDLIIIALPLPVLWKLQLHLKQKVLLACLFALGFFVTVIQIIRILTVWDLKTYTDSKNIVIWSCVENSLGVIIACIPTYGPLFKSFASTVNSYRNRETSRTYALGSVRQDTGTGTGTGPGHGNSNFEPIYESEGQQITEIRSGAQTNDGDSEEHILSEAENLKVYVTSEFTVKSGAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q0B4</accession>
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        <submittedName>
            <fullName evidence="8">Transcription factor, fungi</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PROQFM164_S01g001465</name>
    </gene>
    <organism evidence="8 9">
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q0B4"/>
    <dbReference type="STRING" id="1365484.W6Q0B4"/>
    <dbReference type="OMA" id="FTWDHPC"/>
    <dbReference type="OrthoDB" id="2593732at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053187">
        <property type="entry name" value="Notoamide_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47256:SF10">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47256">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="7">
        <location>
            <begin position="237"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="165"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM27654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="642" mass="72846" checksum="D02474D26D51CDB6" modified="2014-04-16" version="1">MAGLLKMKMKMSHHDNKPFPALAPGPPRLFAPQTSTAVSRPKKNSTACLACKAAKRKANAPCKACRSTNTECHFDPSRDLRRKVAVKRTIQELTNHKYLLESLLSTLGSADQPQFDKVMDLIRKKASFQDIAHAVGSPVTTFGDTQDLSTASRLPILEYGGHAVETSGNAVRRPSDPGNITSSPEEPPSMKPPQWATVSPYARITLESLCDIPLFEVSAKPWTSVTDDDFLVSQLVSLYFTWDHPCSQFLDQRIFLESMKFGNRGSVFCTPLLVNSLLSIASAYSDSPDVLSTPENMFSRGQKFFQEAQRLWEVEDDDHDLPNIQALLMMCCVFKSQGRIKKSWTMLSQAAQLARDIGLFDTPTVSGNDMSSEMERIRTITAWGVFNVSLQMSIELQKIVPLAYPTCGVKLCGDEDFGWIPYPRSNKITFDKKPAHLPQVRKGLAEITMILVDIQKLISEKRRGTSFNELWINANDPFDRLTDWLRRWPSVSAIQRDPIPQVLLLRIKCLQAIIYLFEVFNDPREPQFAQQVQFYQARSAEQTAHCLRIHRQSYGLRHIPIQVVDAVQTGLRILVHQLERSDESRQAFTELCRFGMALSHRFKQTADVIHEIRRNVQHRSIRLPPDVVVLFDHPERWRSLEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q0M4</accession>
    <name>W6Q0M4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Striatin, N-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PROQFM164_S01g003638</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q0M4"/>
    <dbReference type="STRING" id="1365484.W6Q0M4"/>
    <dbReference type="OMA" id="SKCSQEV"/>
    <dbReference type="OrthoDB" id="727118at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013258">
        <property type="entry name" value="Striatin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051488">
        <property type="entry name" value="WD_repeat_striatin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15653:SF0">
        <property type="entry name" value="CONNECTOR OF KINASE TO AP-1, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15653">
        <property type="entry name" value="STRIATIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08232">
        <property type="entry name" value="Striatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Striatin N-terminal" evidence="6">
        <location>
            <begin position="31"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="736"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="94"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="346"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="570"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="94"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="144"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="353"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="581"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM29825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="815" mass="89167" checksum="BC0D3FBDF88D68CC" modified="2014-04-16" version="1">MSWQSPSAMAGIGGMPGAMDGSNGPQGTEYTLQGVMRFLQTEWHRHERDRNAWEIERAEMKSRIGRLEGDLRTSKRLHEALGKHVRMMETALKREREKVKKLSNNEKYEDAKDPKDAARESVNFLKAHRPKPSTDPNNDEERDSENQHECQIEDIDKVRGYLSKASHEIAYHVIPASHPPPDLNDSDMSGQLYGNSQLSQQNLEEAYLQQQRQKANHVMAREMALQNHQPMSNHYSDNAMARAQNQYLPRDAMDRRSMDPQQAPGTAIESRTQVYEQGIVHDRPNQAHETQGPRVIVKEDVNLENLTEERTEDVDGWNFDEPAEQELVATETVPPHRPDTDAFPNANFTYSESTKDGSFPHRTKSTESSRKSDGAIDAREAGTTFKQKQDSNFEVRFVLRGHLDVIRSVIFTGGGSSDEPEICTCSDDGTIKRWIIPGTSGGSGAGSSHSSDITSDFTHRGHEGAVTSLAACSPSQNTFNGGSVLGDGLVFSGGQDASVRLWERGRIDPKATFHEHKDAVWGLCVLPGTMGSVFGDSSSQYGGSDRILLASGAADGYVLIWAIGASPSAANRRQGRRERSNSNSMPSGSNFPTLPQPSVAAPPAFHYTIVHRITRPNSPSPTCISPLSLAGVNFVVSYSNASIIVYDTRTGEEIAGMASLETYDGTPATGVNSVVATTVGFDGTVNLDPNRAMAEEEEVVHGATGSSSVEGVIISGYEDRYIRFFDANSGQCTYTMLAHPAAIASLSLSPDGRELVSAGHDASLRFWNLEKRSCTQELTGYRLMRGEGVCSVVWSRDGRWVVGGGGDGLVKVCSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q0P2</accession>
    <name>W6Q0P2_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S02g000267</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q0P2"/>
    <dbReference type="STRING" id="1365484.W6Q0P2"/>
    <dbReference type="OMA" id="HCDGPAS"/>
    <dbReference type="OrthoDB" id="5362269at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004879828" evidence="2">
        <location>
            <begin position="18"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="60"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="99"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM30118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="173" mass="16642" checksum="FD29F7569564A50E" modified="2014-04-16" version="1">MRFSIFFIAMLTSVTSAASTQDPGPSPTASIGCEPHGDHWHCDGPASTAVSSAISSVTSTASEVEASTTSAEASPASPSPTESIGCEPHGDHWHCDGPAETSSTSASTSTGTSTSESASASDSTSDSASASASASASASASASAGNEDSGTGAIGVQISLLVGLSLVAAGLNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q0T6</accession>
    <name>W6Q0T6_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g003393</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q0T6"/>
    <dbReference type="STRING" id="1365484.W6Q0T6"/>
    <dbReference type="OMA" id="LQAPYNW"/>
    <dbReference type="OrthoDB" id="10258156at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052220">
        <property type="entry name" value="METTL25"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12496">
        <property type="entry name" value="CGI-41 METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12496:SF0">
        <property type="entry name" value="METHYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13679">
        <property type="entry name" value="Methyltransf_32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="1">
        <location>
            <begin position="147"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM29581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="650" mass="73609" checksum="867413A4EB347255" modified="2014-04-16" version="1">MTIKNPLPLSDEWKDPDEYVQALLSFATESVMFMNLCGGVHILDFLTRDPDLYTSLLPEDWRSFFEHHDIHSILQLLLREDIGPLCEPAETNASSENGRTWNGSAFPPASLLEYIRDIRRFSLRREFTTSEKSEPLPMHIAIGMNKKKKHEVEQFSRYVASLSETVNERRGEPLSHIVDFGSGQNYLGRMLASSPYHKHIIAIERKHQYISGASRMDVHARLAKEEKIKTMHNAKHNKLKRQFMQTPELAPDLATAEKPEVPDLNMGAPLELSDAVPEKPAELNEDTTSNMLADMTLEADDVLGSMYRKPHVVHVPKARPEVDTRGTVSYIEHNIQDGYLEPIIEHVVDPKTSVETRTSTEEVIVQSEKKPSDARVMVVSLHSCGNLLHHGVRSLVLNPSVVAIAMIGCCYNLLTERLGPATYKIPILRSAHPRLKKTGSSWDPHGFPMSKLYENYQAKTTTGFKLNITARSMAVQAPHNWGHADSEGFFTRHFYRALLQRVLLDHGIVPKPDVPDDLYKDHTDSPDSGGIALIVGSLRKSAFESFSAYVRAATVKLSLDPIRGELVKKRICTMSEEELQRYETEYLHTRKNLSIVWSLMAFSSQVVEAAIVVDRWQFLREHDSVKECWVETVFEYGQSPRNLAVIGIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q108</accession>
    <name>W6Q108_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Telomere end binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S01g003463</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1365484.W6Q108"/>
    <dbReference type="OMA" id="VWPYSSS"/>
    <dbReference type="OrthoDB" id="5363079at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04497">
        <property type="entry name" value="hPOT1_OB1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011564">
        <property type="entry name" value="Telomer_end-bd_POT1/Cdc13"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02765">
        <property type="entry name" value="POT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00976">
        <property type="entry name" value="Telo_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Telomeric single stranded DNA binding POT1/Cdc13" evidence="2">
        <location>
            <begin position="1147"/>
            <end position="1279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="478"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="637"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1089"/>
            <end position="1112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1295"/>
            <end position="1369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="484"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="520"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="533"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="557"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="596"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="637"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="683"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="745"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="757"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="840"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="870"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1007"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1092"/>
            <end position="1109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1295"/>
            <end position="1304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1306"/>
            <end position="1317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1322"/>
            <end position="1333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1334"/>
            <end position="1343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM29651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="1369" mass="150515" checksum="D18E8D800FD70A71" modified="2014-04-16" version="1">MNAIEQSPASNALAQLTRVPIAQLSPDLEKLAEKSFLAAVALVWPYSSSIKTVSLLLAEPDFRLRGARGQIKVTFHGRVAERVAESHVGIGDTVSLALKDIKFVSNEDAQKTPGRSVAWDAHFENGVSLEIYRSSQPPLIISVEPQVTAPHETEPASPTTPSGKSINPEFDLPSSERPWGSPMFLNSTRTPLGGTIRSAFDPFTEEDGFVPGKGRKKPRYSLHREDWRVVNEPESPREQEAPVDWEQALNQSIDQELEADSASEASMTDDVEAPTYTEDAPQEPLPVFAKPSLELTGSILERHAAESNVVSHGQVDDHETLFHLPTDTPQIRPIPSPGLPIPSPLVSNHAGSTSYFLPWTAPTQFQEIGYAQAGMDTIATPAASSIETHDTDTIDSIHADLETVDPDVESVQQEHVFDAGFIRNDSASYPGSEDLPEKQGVEIIDSIAIDGSDVVEADMAIDTTGDKAQMSNELEQYSAFDDPNLSHDHPARLSDSEDKLDDSPNTKDESPAAQADVVTENATDEAQASDETYQEHLVDSSHLWRDNSGSSSPSEEAGQDESLESSEEVDGSDIAQHDLGIETASDNLGSPQYPGESRDEKHPEPETHLVHYPQLGLTSDQDAIDALGKMIAARDEEYQKMKNTEEEKESEKDVDRPPSQGYREEKDEEVYYAESVENYDSQCESEEDEEDLYGDPSLESRLDEDDFGVVESSGEKPEQEQKLPSQAGSHEVIVLDSDSDDESASNHPVASASQSAERNDHSYCSESEHPAVPPAAAEFASGVQEYPEPWYLDGKDYHGVVEDDSDTDERQSEDSEESEDIERSEYGGESEDREAREDREDREDEEEGEDEYNQQYDRVYESDMDDDESSQDHYETDRASEVASPNLEQDEDKQIKHAELIEEADNDEYYTVANPHAQIGVPVDRDYNEGQSGNADPNLLDGPESHHQGPSLEGKNHAGQYLTGDGQFDLHIPSSARNTIADFPLKHEPTVEEPTVEGPEPLGGRVSPSTTSPLKRQPSTSDPTQKNASPLELIHDFEHQASSTIEETEAPTGLDKTLLLADSPESDQDDGIGAGLIKNTQEIHVDRHDDAVAPSESVEAAEPTATPEPGRSMDVVIESPNTLAVPIPQPSVPDRNASGLRSKLSYFAPLATLIDHYNALVDTISIVHEASPITRAKSSSKDWFVTIELTDPSMAGMTLHAQIFRRHKASMPTLVEGNAILLRDFKVQSFDHTMMLVSADTSAWAVFDGSGPEAETNGPPVEYDSQERAYASGLRRWYDEIGSARVADHMLQAAIERDREERDMTPGSQVRSESGTPDSKRGSQRKRKSTRRITIHELRDGTRYTEVGSPNSRNSSVHELRDGTLYANI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q157</accession>
    <name>W6Q157_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">RTS1</name>
        <name evidence="10" type="ORF">PROQFM164_S01g003518</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the phosphatase 2A regulatory subunit B family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q157"/>
    <dbReference type="STRING" id="1365484.W6Q157"/>
    <dbReference type="OMA" id="ECSHEYT"/>
    <dbReference type="OrthoDB" id="10264446at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051754">
        <property type="term" value="P:meiotic sister chromatid cohesion, centromeric"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901991">
        <property type="term" value="P:negative regulation of mitotic cell cycle phase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098813">
        <property type="term" value="P:nuclear chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000016">
        <property type="entry name" value="Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002554">
        <property type="entry name" value="PP2A_B56"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10257">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE 2A PP2A REGULATORY SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10257:SF3">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT GAMMA ISOFORM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01603">
        <property type="entry name" value="B56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028043">
        <property type="entry name" value="PP2A_B56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="625"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="69"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="98"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="122"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="636"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="656"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="685"/>
            <end position="703"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00064351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR028043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDM29706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="703" mass="80058" checksum="5B8446BEAD550CD8" modified="2014-04-16" version="1">MKGFRQRVHDQLSRAKDNKSSKKKDSNSTPQNQSLGISSAQQPTSPSQGTPTSSTTSLNDSRNKSPDNASPAGTPSAGAPHPGTPVQHYIPQPGTAGQPVSNGPGTPNRQGQPAAPNVIISPSPPHVPPPGAAETMPGDLAPPRKSHVFDRLQTTPKDISEGIRTPKRQHSSRFDISDQRQRELEKLPGFHEVPPNRRQDLFMQKIDQCNIIFDFNDPTADMKSKEIKRLALHELLDYVANNRSVITEPMYPRVVEMFAKNLFRPIPPPMTPQGEAFDPEEDEPVLEVAWPHIQVVYEFFLRFIESQDFNTNIAKGYIDHQFVLSLLDLFDSEDPRERDFLKTTLHRIYGKFLNLRSYIRRSINNVFFQFMYETERHNGIAELLEILGSIINGFALPLKEEHKLFLTRVLLPMHKVKSLSMYHPQLAYCIVQFLEKDSSLTEDVVLGLLRFWPKTNSTKEVMYLNEVEDIFEVMDPGEFAKVQEPLFNQLAKSVASPHFQVAERALYFWNNEYFCNLVSDNVETILPLMFAPLYENSKGHWNRTIHSMVYNAMKMFMEINPQLFDECSHDYTEHQNNADQREKIRSERWDVIEQQAKDRKNGIPPPPAPPLDVPEAIDEVEAMTHESQKRLNSLKLQDDPDISKDRPSREGTPNSTRRRGSIRSTGRRRRSGSGSEIRPRRRSVGSGTSATNVQILHRSNSTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q399</accession>
    <name>W6Q399_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="13">V-type proton ATPase subunit c</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">VMA16</name>
        <name evidence="13" type="ORF">PROQFM164_S02g001223</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="function">
        <text evidence="9">Proton-conducting pore forming subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10 11">V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d, e, f and VOA1). The decameric c-ring forms the proton-conducting pore, and is composed of eight proteolipid subunits c, one subunit c' and one subunit c''.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the V-ATPase proteolipid subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1365484.W6Q399"/>
    <dbReference type="OMA" id="TSPYMWG"/>
    <dbReference type="OrthoDB" id="10264021at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033179">
        <property type="term" value="C:proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18177">
        <property type="entry name" value="ATP-synt_Vo_c_ATP6F_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18178">
        <property type="entry name" value="ATP-synt_Vo_c_ATP6F_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.610:FF:000002">
        <property type="entry name" value="V-type proton ATPase proteolipid subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.610">
        <property type="entry name" value="lithium bound rotor ring of v- atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000245">
        <property type="entry name" value="ATPase_proteolipid_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10263">
        <property type="entry name" value="V-TYPE PROTON ATPASE PROTEOLIPID SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00122">
        <property type="entry name" value="VACATPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="F1F0 ATP synthase subunit C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="7"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="128"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="165"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="12">
        <location>
            <begin position="47"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="12">
        <location>
            <begin position="132"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00046480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDM31073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="200" mass="20648" checksum="B1CEFCCA31ABA8AF" modified="2014-04-16" version="1">MAYLYPAGVSTTALIVVGLYMLFHGDGEAFNVGRFLEEVSPYAWANIGIASCIGFSVVGAAWGIFLTGSSIVGGGVRAPRIRTKNLISIIFCEVVAIYGVIMAIVFSSKLSPVAEGGIHTSSNYYTGYAVFWGGITVGVCNLICGISVGINGSGAALADAADPSLFVKILVIEIFSSVLGLFGLIVGLLVAQKAVILEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q427</accession>
    <name>W6Q427_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S02g001250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q427"/>
    <dbReference type="STRING" id="1365484.W6Q427"/>
    <dbReference type="OrthoDB" id="4360351at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056681">
        <property type="entry name" value="DUF7779"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25000">
        <property type="entry name" value="DUF7779"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7779" evidence="1">
        <location>
            <begin position="18"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM31100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="142" mass="15584" checksum="2A706EDC63252E67" modified="2014-04-16" version="1">MSSQYEDGSTSCKASSRSLSIEGKILLNILAFFDPHAIPEWLLSNPKANITDPSLKFLSNDSRFGGALIDLTNASLIVRSPELEMITLDQITQSTVFSGLPKAELSIYLDSAIQLQKLLNLKQQKNKKQKEMTDAGIEPAIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q446</accession>
    <name>W6Q446_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S02g000881</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q446"/>
    <dbReference type="OrthoDB" id="3853793at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004879894" evidence="1">
        <location>
            <begin position="23"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM30731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="75" mass="7780" checksum="5B299B00E56258CA" modified="2014-04-16" version="1">MLSSTIITSLILGLSQLSTGIALPSTPPPTPEPGFIINHVASDYFPNSKGDLSAFDVDVHYGGDVCLSNRATGCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q465</accession>
    <name>W6Q465_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Alpha-1,2-mannosidase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PROQFM164_S01g002755</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q465"/>
    <dbReference type="STRING" id="1365484.W6Q465"/>
    <dbReference type="OMA" id="YQDPIAC"/>
    <dbReference type="OrthoDB" id="449263at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000224">
        <property type="term" value="F:peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006516">
        <property type="term" value="P:glycoprotein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.60:FF:000005">
        <property type="entry name" value="Alpha-1,2-mannosidase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1610.10:FF:000002">
        <property type="entry name" value="Alpha-1,2-mannosidase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.98.10:FF:000010">
        <property type="entry name" value="Alpha-1,2-mannosidase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2080.10:FF:000001">
        <property type="entry name" value="Alpha-1,2-mannosidase subfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.60">
        <property type="entry name" value="alpha-1,2-mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1610.10">
        <property type="entry name" value="alpha-1,2-mannosidases domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2080.10">
        <property type="entry name" value="GH92 mannosidase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005887">
        <property type="entry name" value="GH92_a_mannosidase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041371">
        <property type="entry name" value="GH92_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012939">
        <property type="entry name" value="Glyco_hydro_92"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050883">
        <property type="entry name" value="PNGase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01180">
        <property type="entry name" value="aman2_put"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12143">
        <property type="entry name" value="PEPTIDE N-GLYCANASE PNGASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12143:SF23">
        <property type="entry name" value="PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07971">
        <property type="entry name" value="Glyco_hydro_92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17678">
        <property type="entry name" value="Glyco_hydro_92N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004879896" evidence="2">
        <location>
            <begin position="24"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 92 N-terminal" evidence="4">
        <location>
            <begin position="30"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 92" evidence="3">
        <location>
            <begin position="283"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="767"/>
            <end position="792"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDM28944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="792" mass="87410" checksum="FC6046EFBF994048" modified="2014-04-16" version="1">MAILQRNKLCSLLLLQCVLGTVATQDDLHYVNPLIGSTNGGNVFAGASLPYGMAKPVADVDGQNTGGFSTDGSNVTGFSHMHDSGTGGNPSMGNFPLFPQYCKDNILDNCKFPKAARAVHYKNDSVVAQPGYFALTLENGIKAEMTAARRTALYRFTFPKGKLADGTDLNPLISVDLTDLWDSRQNASISLDADKGQIKGNGTFLPSFGAGSYKSYFCADFGDAEVDEAGIWVNDRAGSVQELFVTRGFNNFYLQAGGYMSFGRPKNGIVTVRVGISFVSSDQACKNAEAEVPEPEDAFDHLRKSAEAAWKEKLSPIKVTSGGVSKDMISSFWSGIYRTMLSPQDLTGENPLWKSDEPYFDSFYCLWDAFRAQHPFLTIIDPKSQSKMVRSLLDTFKHEGWLPDCRMSLCKGWTQGGSNADIVLADAYVKNLTGIDWELAYKAMVNDAENEPLEWSYEGRGGLQSWKHLNYIPYLDFDYIGFGTNSRSISRTLEYAYNDYGLSVVAKGLGKNDYTTYLSRSGNWQNLYKEDQKSFLGNGTDTGFTGFFQPKYINGTWGYQDPIACSALASWCSLTSNPSETFESSIWEYLFFVPHDMAKLIKIVGGPESFVSRLDYFHTSGLADMGNEPVFLTVYDYHYAGRPGLSASRAHAYIPSSFNATHSGLPGNDDSGAMGSFLAWSMMGLFPNPGQNVYLIIPPFFKAVAITHPETNQTATIRNVNFDKTYKNIYIQSAKLNGKPYTKNWIGHEFFTRGMMLELTLGNKESDWGTRKEDLPPSLSDSISVGGTHDGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q4C4</accession>
    <name>W6Q4C4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S02g001345</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q4C4"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM31195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="51" mass="6108" checksum="FFA903DD48881E7E" modified="2014-04-16" version="1">MALPPGREPRSYRRSPSKSLPILQYDTTHGVNDKKSFNNNWREQNRQFEFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q691</accession>
    <name>W6Q691_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S02g001976</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q691"/>
    <dbReference type="STRING" id="1365484.W6Q691"/>
    <dbReference type="OMA" id="WEMLSSH"/>
    <dbReference type="OrthoDB" id="5945798at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="310"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="674"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="331"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="353"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="394"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="450"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="470"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="508"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="674"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="841"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="913"/>
            <end position="933"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM31825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="933" mass="102809" checksum="6D9A13653BE9DBD0" modified="2014-04-16" version="1">MKALGIYFGRHWAGIPALGERGIPFSFLQSNIFLSLLRISVCIESGQSDLKSWRSSPRHVWCAAARAAAAPAISINQPPRPTLPRLFTFRISNCFRFSLNCFTLCIEYWSVQPSELSDATLTLSPNPQFYPPFLEVSRHTPQAPDEVHDSYDPSTFTTFARQRQPTVQRPSNSSGHQLRPSSAASQRPLRRIPRQAEVRQSPHRRAVSLRAPVPHRHQPARTTPVSVQRAAASGIADLRPALSEAETDDNGSTIDDPYQLLHTSYWPQRNTGVSSRTASAILFALEEAIRGPLQLSTDWDEVNASMSDMVGVAGPAGPVNNSRGQNGGSRVPQNPISGTSQPPSGMRTPTDIMRQRRDREARRKAESEAREREQEELERQQLEEKQAEAEAEAQKYAQAQAQQYAAGVAAENASQSRIRAPRPARGPEGQSQTVPVASGAVPGYRPAPDNTPSTRPSEYQTAPPTVGTGQANQARPPQTTAQQPQHGRSQSAAEIGGQPKPSGFSKSAQALPAGQGAPQALQQPKRVGFPHAFERWETLSSHWEGLTSYWMRKLEQNNEDLERDPISQQLARQITDLSAAGANLFHAVVELQRLRASSERKFQRWFFDTRAEQERSKEVQADLERQLKEERQGRADAFSTAQQSEKDKVKAEELLKEMRRELQISKEEARRAWEELGRREQEERDRTNSLRNGEPTLVGGVQVVPMVSGLPSRHNTTRPQTREGPYPGQTATTVGTDAYGKPAGSAGQYYEDGTPMSPVGSDPFIEPKKVDPPTSKVPYPRPLYAHDNTTVPYPATSEPDARSYVGSSEAGDEEYAPYPHDPHGDSLSYPPGPPSEESEEYEHSLLDEHYIPESAYTSAPSSVPPPAPASAADYSGAGWGPGTGWESVTPRHRHPTRLSDVLEEDEHSRTTPSRASLASRSQAGRSQASRSIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q7R8</accession>
    <name>W6Q7R8_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Kynurenine formamidase</fullName>
            <shortName evidence="3">KFA</shortName>
            <shortName evidence="3">KFase</shortName>
            <ecNumber evidence="3">3.5.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Arylformamidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">N-formylkynurenine formamidase</fullName>
            <shortName evidence="3">FKF</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PROQFM164_S02g000418</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the hydrolysis of N-formyl-L-kynurenine to L-kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>N-formyl-L-kynurenine + H2O = L-kynurenine + formate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13009"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:57959"/>
            <dbReference type="ChEBI" id="CHEBI:58629"/>
            <dbReference type="EC" id="3.5.1.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid degradation; L-tryptophan degradation via kynurenine pathway; L-kynurenine from L-tryptophan: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="domain">
        <text evidence="3">The main chain amide nitrogen atoms of the second glycine and its adjacent residue in the HGGXW motif define the oxyanion hole, and stabilize the oxyanion that forms during the nucleophilic attack by the catalytic serine during substrate cleavage.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the kynurenine formamidase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.9" evidence="3"/>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q7R8"/>
    <dbReference type="ESTHER" id="penro-w6q7r8">
        <property type="family name" value="Kynurenine-formamidase"/>
    </dbReference>
    <dbReference type="OMA" id="YWVIYIH"/>
    <dbReference type="OrthoDB" id="420264at2759"/>
    <dbReference type="UniPathway" id="UPA00333">
        <property type="reaction ID" value="UER00454"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004061">
        <property type="term" value="F:arylformamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034354">
        <property type="term" value="P:'de novo' NAD+ biosynthetic process from L-tryptophan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:L-tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03014">
        <property type="entry name" value="KFase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049492">
        <property type="entry name" value="BD-FAE-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027519">
        <property type="entry name" value="KFase_ver/fungi-typ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF33">
        <property type="entry name" value="KYNURENINE FORMAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20434">
        <property type="entry name" value="BD-FAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0823">Tryptophan catabolism</keyword>
    <feature type="domain" description="BD-FAE-like" evidence="4">
        <location>
            <begin position="34"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="HGGXW" evidence="3">
        <location>
            <begin position="39"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="240"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF20434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDM30269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="314" mass="34156" checksum="7C46402D46578DE9" modified="2014-04-16" version="1">MSDHSKTQTIVYGQDHNLQSIAVTTLAPRKDGYWVIFIHGGAWRDPAVTSTSFSAAESILRERDLPIAGFASISYRLSAHPNHPQDSNTAPKDFQNAKHPDHITDVEAALSFLQNTYGFGTRYILVGHSCGATLAFQAVMGTVSGHREQTVAIPGPSGSLPTTAPVQPTAIVSVAGIYDLRLLRDTHADISAYQEFIEGAFGADEMLWDEVSPAKVTGSRGVEGGWNSGRLVVLAYSKDDGLVDAPQIEVMEKTLRNWEKAEAQIPVQEASNCDRRVRILSITGAHDEAWENGEQLARAVTFAFEQLHEMGLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q815</accession>
    <name>W6Q815_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S02g002676</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q815"/>
    <dbReference type="OMA" id="CHSEPGC"/>
    <dbReference type="OrthoDB" id="426718at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021838">
        <property type="entry name" value="DUF3431"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37490:SF3">
        <property type="entry name" value="DUF3431 DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37490">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11913">
        <property type="entry name" value="DUF3431"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM32525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="399" mass="45640" checksum="63D07EACCE986BA6" modified="2014-04-16" version="1">MLLPRRAVFFLGVCFFLAFFLTTRSLSRPWRDVPQVIGLGDLVSSSNTTGAWNTTRGHTSKNLYAPLPDFISGIPKPSGYNYSKVMVVTRTKGEDTSWIAEELPDWDHAIYVADDPKAPLHPPKNKGHEVMIYLTYIVDHYDQLPDVAVFMHSHQFAWHNDNLFAGDAAQLLRRLNLNRVIREGYMNTRCGFGPGCPAWMHPGALEEDESKQEEIMLARAWGELFPDQEIPSVLAQPCCAQFAVSRDRIRSIPRARFVFYRDWLLSTDLSDYIAGRIWEYLWQFIFTGQPVLCVEENVCLCDGYGFCFGGNEEWNNYREAEAKRNEIQQELDNWMWLSDIGFADESDDSDGEKGNVLVSQLQEKQQEIIGLLTAAMERGQNPQYRAQEAGRPWKEGDGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q9J5</accession>
    <name>W6Q9J5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S03</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S03g000022</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q9J5"/>
    <dbReference type="STRING" id="1365484.W6Q9J5"/>
    <dbReference type="OrthoDB" id="3256520at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM33298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="70" mass="8252" checksum="B4D1DDF95B58743E" modified="2014-04-16" version="1">MTANTANTVVAFDLYGTLLSTQSIAKHLEKYYDNAKAQSISALWRRYQLEYTWRLNSMGKQHFQAWRSNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q9Q4</accession>
    <name>W6Q9Q4_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein DOM34 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">dom34</name>
        <name evidence="12" type="ORF">PROQFM164_S03g000092</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the Dom34-Hbs1 complex, a complex that recognizes stalled ribosomes and triggers the No-Go Decay (NGD) pathway (PubMed:20890290). In the Dom34-Hbs1 complex, dom34 recognizes ribosomes stalled at the 3' end of an mRNA and engages stalled ribosomes by destabilizing mRNA in the mRNA channel. Following ribosome-binding, the Dom34-Hbs1 complex promotes the disassembly of stalled ribosomes, followed by degradation of damaged mRNAs as part of the NGD pathway.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the eukaryotic release factor 1 family. Pelota subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q9Q4"/>
    <dbReference type="STRING" id="1365484.W6Q9Q4"/>
    <dbReference type="OMA" id="DDLWHLK"/>
    <dbReference type="OrthoDB" id="10249111at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990533">
        <property type="term" value="C:Dom34-Hbs1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070651">
        <property type="term" value="P:nonfunctional rRNA decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070966">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, no-go decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070481">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, non-stop decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032790">
        <property type="term" value="P:ribosome disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071025">
        <property type="term" value="P:RNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.60:FF:000004">
        <property type="entry name" value="Protein DOM34 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.870:FF:000001">
        <property type="entry name" value="Protein pelota homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000008">
        <property type="entry name" value="Protein pelota homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.60">
        <property type="entry name" value="eRF1 domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.870">
        <property type="entry name" value="Pelota, domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042226">
        <property type="entry name" value="eFR1_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005141">
        <property type="entry name" value="eRF1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005142">
        <property type="entry name" value="eRF1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005140">
        <property type="entry name" value="eRF1_Pelota-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038069">
        <property type="entry name" value="Pelota/DOM34_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058547">
        <property type="entry name" value="Pelota_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004405">
        <property type="entry name" value="TF_pelota"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00111">
        <property type="entry name" value="pelota"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10853">
        <property type="entry name" value="PELOTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10853:SF0">
        <property type="entry name" value="PROTEIN PELOTA HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03464">
        <property type="entry name" value="eRF1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03465">
        <property type="entry name" value="eRF1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26356">
        <property type="entry name" value="Pelota_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01194">
        <property type="entry name" value="eRF1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159065">
        <property type="entry name" value="Dom34/Pelota N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0469">Meiosis</keyword>
    <keyword evidence="6 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0498">Mitosis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="eRF1/Pelota-like N-terminal" evidence="11">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDM33368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="403" mass="44289" checksum="39C02445D83A7015" modified="2014-04-16" version="1">MRCIKNKIEHNGSGTVTLCPDEPEDMWHAYNLIRPGDILRASAIRRVTTVQDTGSTSSARVHLNLVIRVKNLDFDPQSSQLHVSGQIINETPHTKIGQFHTLDLELNRNFTLEKEVGADGEGVGWDSIAIESLKDAVDEGGKRRAEAVAVVMQEGLAHICFIGQFQTILKQKIEMSVPRKRQGGGDHDKGMNKFFKVTLETLLRQMEFNTSLTSGANNEAVRPVLLASPGFVAAGFQKYIQSEASTTTPGLKRLLPSLVVVHSTSGYTNSLSEVLQSPAVKSLLADTKYARETKLMDDFLEQLRKETNKATYGPREVDYAVEQGAVGRGGGVLIVSNRLFRSQDIAERKRWVALVDRVRDVEGGDVRILSSDHESGKRLEGLGGIAALLTFPVIEPDLDSDAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q9W4</accession>
    <name>W6Q9W4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Zinc finger, ZZ-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PROQFM164_S03g000172</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q9W4"/>
    <dbReference type="STRING" id="1365484.W6Q9W4"/>
    <dbReference type="OMA" id="DEWWNDP"/>
    <dbReference type="OrthoDB" id="2122982at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02340">
        <property type="entry name" value="ZZ_NBR1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028846">
        <property type="entry name" value="Recoverin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000433">
        <property type="entry name" value="Znf_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043145">
        <property type="entry name" value="Znf_ZZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055">
        <property type="entry name" value="CALCIUM BINDING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055:SF187">
        <property type="entry name" value="EF HAND DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G07310)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00569">
        <property type="entry name" value="ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00450">
        <property type="entry name" value="RECOVERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00291">
        <property type="entry name" value="ZnF_ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01357">
        <property type="entry name" value="ZF_ZZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50135">
        <property type="entry name" value="ZF_ZZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="ZZ-type" evidence="9">
        <location>
            <begin position="269"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="10">
        <location>
            <begin position="409"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="10">
        <location>
            <begin position="445"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="43"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="198"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="508"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="580"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="702"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="880"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="46"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="597"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="614"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="716"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="728"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="897"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="910"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="933"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="948"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1019"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="1038"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1052"/>
            <end position="1062"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDM33448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="1121" mass="126526" checksum="9FFC3D5FC6DBC042" modified="2014-04-16" version="1">MSDSRPGPVSLARYRPILYLFTGVAAAYAILYVHNNVISQPSSSSLRRRNAVRRTRPTEAEEPGIADTPSYRAITHLEQLEHQNGVYGTFRIETEDGRRVESGLLPSLLATRDQLMEEVGVPPAHAERMREMMEDTFLESFLALDFPSAHILPEDTAERTYLTEQLQRRGISRAGIERALVRFNGDTNYGEELRRRRQNGERVTLSTSTFPDVSAPPQNIDGGETVVDDQSVFSWRDGNNDPSNREGQNLLNLLYHIAEDQARRDGYIHRGVTCNSCGAMPIQGIRYRCANCIDYDLCETCEAMQVHIKTHLFYKVRIPAPFLGNPRQSQPVWYPGKPSMLPRSLPRPLAKRLMKDCNFENTELDALWDQFRCLANYEWANDPNKLHMAIDRKTFDRCFVPNTSIRPPPPSLIYDRMFAFYDTNGDNLIGFEEFLKGLASLNNKSNDERLRRVFRGYDIDGDGFVERKDFLRVFRAYYALSRELTRDMVAGMEDDFLEGGARDVVLGSQPISSAFPGSIPSGERSRTGEGKSMNSEGDMEIIDNEGILRQDGDDTGDRHLVVGDAAVRAQFSRMRPLFPSTLRLAPAETTPRPPDAIESDQNEDDEEEDEDGASESGSDQSSSSVASGTWPPVEHILEEDIISALGTYIPAREITDPIDRARVADAVYHRMREDDQRRVFDARQRGIDERWRRRAFYTDEEDGATIPAGYERDPAIDDFSDDEDLNESVSRPPSFRSRSSSKVRFQDDLNDDEYDIRSNPSTSSRSIPVGERWGGFEIPEVERDVGKEILYQVTQQGFNELLDILFKPKEDLMMEVYRTRADRKLWAREIELAAKEDPSKRTTTENPPVEEELEEIINSQPLDDLLQRAGYQIRSPVLVPENTGPVLAPSPGPTVSDEGDEDEYEDDDDVRPTHLADPGRDTGFGQARPFVESATTSATSSDYGDDIAASASGVGPSSPVVEEERLHCDPTLPQHRPDEPFVMTQEVIAESDSDLEESPIRNTNPDLPDRFRLQPGTISLPAPSSPRSSPEAEATAPKLPPSPMQPLPPPHRVNDLPRDTAPRRPSPRTLARWVYLDQVERENKERGHGARLNFEEFSRRMAADRGRRLAFVASWIEMASF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W6QAI3</accession>
    <name>W6QAI3_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Actin cortical patch SUR7/pH-response regulator PalI</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S03g000149</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QAI3"/>
    <dbReference type="OMA" id="MNWAFVI"/>
    <dbReference type="OrthoDB" id="4480814at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051285">
        <property type="term" value="C:cell cortex of cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009571">
        <property type="entry name" value="SUR7/Rim9-like_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052413">
        <property type="entry name" value="SUR7_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28019">
        <property type="entry name" value="CELL MEMBRANE PROTEIN YLR413W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28019:SF3">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_6G07470)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06687">
        <property type="entry name" value="SUR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="161"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="192"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="239"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="323"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM33425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="342" mass="36965" checksum="8234D8366E39A300" modified="2014-04-16" version="1">MGKAGRVACIFTPYVLTIASLICIILVGLGCTKASSSTLNNLYFIRLDLSNISEGSALTSEITDRLSAAGITDVTADEVSETIETLQADANISDFYDIGLWGYCEGNITNSTDTVSSCTDPKAEFYFNPSTILGVSETELEKEIGSDLKKTMKIYKAVSKWMFIAYLVAFIATCAQVLLGIFAIFSRWGSCVTTIVSIVSFLFTLGASLTSTIMFSIAKSSLGTVLEVYGIDVSLGKNIYAATWLAVAFSLGATFFWMLSTCCCSGRSPYGHRDRSPRGITAEKAPYTYEPIGAAHPPFGSQQPLVPQHGYSTSYPAATHNNDIPMTHNNQQSSAYEPFRHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W6QAL5</accession>
    <name>W6QAL5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Genomic scaffold, ProqFM164S03</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PROQFM164_S03g000447</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QAL5"/>
    <dbReference type="STRING" id="1365484.W6QAL5"/>
    <dbReference type="OMA" id="VVIMVTY"/>
    <dbReference type="OrthoDB" id="3903189at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF110">
        <property type="entry name" value="UBID FAMILY DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="133"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="177"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="214"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="248"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="29"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="285"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="329"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="294"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM33723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="405" mass="46255" checksum="3B168A9240CB4207" modified="2014-04-16" version="1">MGNESPTPNQLFTEAIVFWSIGLVIYVGRVVARIIANGSYKRLFVDDYVMAATFAIYTTLLVLIQISARYATNLMDPKDYDMVLADPKQVSDRIYGSKIVIGLEQCMLISTWGVKTCMLMLYWRITQNLKSNLYIKILAVYVAVGFVVIMVTYYAVYCRPFSQYWAMPVDNMQCATYQYYSITQAVFNISSDAVMFAIPIPLLIKAQLKRRRKVVLIGVMSLGLFTIIAAILNKYFNFASPLTTTYQIWYIRESSTAIYVANLMCWWPLLRKLFGVKAFQYNSNRAQKHGKPDNQNNDSSGSYSNNSHSHPSSNFSRSWKLPFHRGNKNTTPGKYSGAKGPSTEPINRSNAEFINDMHRVEAVPLENWTTKHTRTDTSITQDSRNSLEKQCDVELYQKQHARSLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2024-10-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>W6QB24</accession>
    <name>W6QB24_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S03</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S03g000389</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QB24"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM33665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="41" mass="4769" checksum="E781EC6973DF8542" modified="2014-04-16" version="1">MIDDRLQFPSTSVYVVLGESKVMHRKVVFTNSALFRPFPRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W6QBF4</accession>
    <name>W6QBF4_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">2,3-bisphosphoglycerate-independent phosphoglycerate mutase</fullName>
            <ecNumber evidence="6">5.4.2.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Cofactor-independent phosphoglycerate mutase homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">gpmI</name>
        <name evidence="18" type="ORF">PROQFM164_S03g000767</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2R)-2-phosphoglycerate = (2R)-3-phosphoglycerate</text>
            <dbReference type="Rhea" id="RHEA:15901"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
            <dbReference type="EC" id="5.4.2.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the BPG-independent phosphoglycerate mutase family.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.12" evidence="6"/>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QBF4"/>
    <dbReference type="STRING" id="1365484.W6QBF4"/>
    <dbReference type="OMA" id="FMDGRDT"/>
    <dbReference type="OrthoDB" id="1886626at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00186"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004619">
        <property type="term" value="F:phosphoglycerate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006007">
        <property type="term" value="P:glucose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16010">
        <property type="entry name" value="iPGM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1450.10:FF:000001">
        <property type="entry name" value="2,3-bisphosphoglycerate-independent phosphoglycerate mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.720.10:FF:000001">
        <property type="entry name" value="2,3-bisphosphoglycerate-independent phosphoglycerate mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1450.10">
        <property type="entry name" value="BPG-independent phosphoglycerate mutase, domain B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01038">
        <property type="entry name" value="GpmI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011258">
        <property type="entry name" value="BPG-indep_PGM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006124">
        <property type="entry name" value="Metalloenzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036646">
        <property type="entry name" value="PGAM_B_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005995">
        <property type="entry name" value="Pgm_bpd_ind"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01307">
        <property type="entry name" value="pgm_bpd_ind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31637">
        <property type="entry name" value="2,3-BISPHOSPHOGLYCERATE-INDEPENDENT PHOSPHOGLYCERATE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31637:SF0">
        <property type="entry name" value="2,3-BISPHOSPHOGLYCERATE-INDEPENDENT PHOSPHOGLYCERATE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06415">
        <property type="entry name" value="iPGM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01676">
        <property type="entry name" value="Metalloenzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001492">
        <property type="entry name" value="IPGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64158">
        <property type="entry name" value="2,3-Bisphosphoglycerate-independent phosphoglycerate mutase, substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9 15" id="KW-0464">Manganese</keyword>
    <keyword evidence="7 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metalloenzyme" evidence="16">
        <location>
            <begin position="4"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="BPG-independent PGAM N-terminal" evidence="17">
        <location>
            <begin position="90"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphoserine intermediate" evidence="13">
        <location>
            <position position="70"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="161"/>
            <end position="162"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="265"/>
            <end position="268"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="339"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="406"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="410"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="447"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="448"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="465"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00071648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00083354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001492-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001492-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR001492-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF06415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CDM34043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="517" mass="56759" checksum="0BCC7E6522A0C993" modified="2014-04-16" version="1">MADQKVALIVIDGWGIAGPDSPPQGDAIAAADTPHMSGFAEPNSKTAQGYAELEASSLAVGLPEGLMGNSEVGHLNIGAGRVVWQDSVRIDQTLKKGEMGKVPSIVKAFTRAKEGNGRLHLLGLVSDGGVHSSIAHLFALLQVAKDMQIPEVFIHFFADGRDTDPKSADKFLQQVLDKTQEIGVGVIATIVGRYYIMDRDKRWERVEIGLKGLVTGEGEDSSDPLQTIKERYEKNENDEFLKPIIVGGKERRVQDDDTLFFFNYRSDRVREITQLLGDYDRSPLPDFPYPKNISLTTMTQYKTDYNFNVAFPPQHMGNVLAEWLGKKNLQQCHIAETEKYAHVTFFFNGGIEKVFPGEVRDMIPSPRVATYDLDPKMSAAAVGDKMAERLGENKFDFVMNNFAPPDMVGHTGVYEAAIQGVAATDKAIGEIYEACKKNNYVLFITADHGNAEEMLTEKGTPKTSHTLNKVPFVMANAPESWSLKKDGVLGDVAPTVLAAMGVEQPKEMTGTSLLVKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>W6QBX8</accession>
    <name>W6QBX8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="10">SMAD/FHA domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PROQFM164_S03g000684</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QBX8"/>
    <dbReference type="STRING" id="1365484.W6QBX8"/>
    <dbReference type="OMA" id="EKYAFYR"/>
    <dbReference type="OrthoDB" id="5954824at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd20024">
        <property type="entry name" value="FH_FOXJ2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22701">
        <property type="entry name" value="FHA_FKH1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000030">
        <property type="entry name" value="Forkhead box protein K2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.20:FF:000039">
        <property type="entry name" value="Forkhead transcription factor Fkh1/2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018122">
        <property type="entry name" value="TF_fork_head_CS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030456">
        <property type="entry name" value="TF_fork_head_CS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45881">
        <property type="entry name" value="CHECKPOINT SUPPRESSOR 1-LIKE, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45881:SF1">
        <property type="entry name" value="FORK HEAD PROTEIN HOMOLOG 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00657">
        <property type="entry name" value="FORK_HEAD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00658">
        <property type="entry name" value="FORK_HEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="FHA" evidence="8">
        <location>
            <begin position="124"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="Fork-head" evidence="9">
        <location>
            <begin position="335"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="6">
        <location>
            <begin position="335"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="241"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="420"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="459"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="486"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="553"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="605"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="262"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="272"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="300"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="426"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="465"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="500"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="554"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="662"/>
            <end position="677"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDM33960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="720" mass="79240" checksum="3558D3A67A33250E" modified="2014-04-16" version="1">MPLTNRRRARRKEIQLQETSDAEAPDSSPSRPSAKKRKVDRRTSPPRNVKHESADEAEDSTGEHEPATNQDLVDLVISYLNTPREELRVSRDHSNTKTENTQRIQAYAKIAGRNWTYYVKTLHVNIGREPDREQRAVEQSSPVTIAARALPDVHVDLGPSKFVSRLHAEIFYDGEETPAWHIRVNGRNGVRLNNAIVKRGTDAILSCGDIIEVANTQMMFVTPGDEANIQPSFIERAQRIASGQEPDPASVAWDASQHAHPQHSQNSEATRPSSSGGPSLAPAPKFNKRQVTPPPRSPDTAGQRTAKQSPLYNRGMMMESTEEIDYSKDSSKDLKPPYSYATLIAQAIFSSEEEKLTLNSIYNWIMDKYAFYRHSQSGWQNSIRHNLSLNKAFQKVPRRTDEPGKGMKWQIAVEYREEYRKKQTRKGGTQSSAPSSPATKEPPSSARGTHVSKIDTSFSATARKSPPVSSPGFSSFPVAPVEAYTPERGSRLGRGLGSDHPLRHMNPRDYDEPSPLPSRSHNHHSSISTQVQNSSNNLARAYGMSDNVAGSPPVLSSSYYNEEPSSMITPAPQRQQPRLPPPSTAQIPSKFMPMSSPAQFWKFADIGSTPARPPPDMSPLKGEVEDRIIGGFPSSSPPPPNLVSPSKPGTSNGLGSGRTLPPLQSDSGDMGPNGTSHARNEEREEEDDDDNGSGFDLARGFEPIGSYHRQLGNAARAAAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W6QCS5</accession>
    <name>W6QCS5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S02g002145</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QCS5"/>
    <dbReference type="OMA" id="WHAQDID"/>
    <dbReference type="OrthoDB" id="4186058at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM31994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="221" mass="25332" checksum="290CB74F3F53DBC0" modified="2014-04-16" version="1">MEDLPMNDTSPDKFKEPIEYFADLTSDAAADHQPKEREQSMDDSGPSTPAHDMDPLEDSDKIRVIKPYDIEEPDDELETSLPRVDRLCLPDRFERWQRDLTDYLNDMGYEPDGSNSNTIISARKRGQKRKPAHNTLATQQCYPFFAQGHASAETQTEVHEHRPKRQRFSEIPKWHAQDIDSFGAFREANENESSGSETASIDLNGNDPMNNWPMADEMDID</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>W6QDF0</accession>
    <name>W6QDF0_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S03</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S03g001443</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QDF0"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM34718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="190" mass="23413" checksum="43F3604CEE4FFDA2" modified="2014-04-16" version="1">MCIVTICKKVYPRGTSFWHAHFEICDYYASNLCHILFIFEDFVRFPRRRESEPVRSRNFNFREHLTWNGGSEFIGPISSFKPSVDEVWYLLLLILLDYWFNRGERRVIQRDRVIERHLDRLGPGRMLGVIRSVAYEEDDDYYEDQEFFHEEYDEFYEGDEVFYRGDEVYYQDVEYSRQVVEYIYERVEYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W6QDM3</accession>
    <name>W6QDM3_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Short-chain dehydrogenase/reductase SDR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S03g000905</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QDM3"/>
    <dbReference type="STRING" id="1365484.W6QDM3"/>
    <dbReference type="OMA" id="LGAHYWR"/>
    <dbReference type="OrthoDB" id="542013at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF148">
        <property type="entry name" value="NAD(P)-BINDING ROSSMANN-FOLD SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM34181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="295" mass="32317" checksum="5B1AD6B44F212B59" modified="2014-04-16" version="1">MSSIAKTVIATGTSSGLGFETIKQLLQQTQPYSFILGVRDTEKTRVAYDDLKFDTSKHSVSILPLDLLNLKSVQSFAKQALSELGKRPLNYLFLIAGFLASAEGPGPHGSQWCESYVVNHLAQHYLTHEFAETLSASRSRIVIVSSGAIRNVRGGDPATLEVDLKANSGANARVVYSASKFTQLLGAHYWRRSLPNCTVVAVSPGLIPNTKLAQHSSLGLSMDMPDAKTVPEGAQNILRAVTVENLPADPEQIFLTSWGEWWPKDVYALSLDPALQDKWCLSKEDIEKSEPVFKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W6QDW4</accession>
    <name>W6QDW4_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">hsk1</name>
        <name evidence="9" type="ORF">PROQFM164_S02g002525</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QDW4"/>
    <dbReference type="STRING" id="1365484.W6QDW4"/>
    <dbReference type="OMA" id="QGFTMEK"/>
    <dbReference type="OrthoDB" id="10020333at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044773">
        <property type="term" value="P:mitotic DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14019">
        <property type="entry name" value="STKc_Cdc7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000478">
        <property type="entry name" value="Cell cycle protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167:SF23">
        <property type="entry name" value="CDC7 KINASE, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167">
        <property type="entry name" value="OVARIAN-SPECIFIC SERINE/THREONINE-PROTEIN KINASE LOK-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="74"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="101"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="285"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="442"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="44"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="54"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="103"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="455"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM32374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="474" mass="54069" checksum="9AE6EE6FD6D398B8" modified="2014-04-16" version="1">MSAIRAAPGVFELKRNKSRHEPQLQHKYSLGHDDEPVSPSDAPQESEYEEEVEESVREDMRKLEDTFPGISDRFRLVNRIGEGTFSTVYKAEDLHYDAHQNDWDVSTPTQDNYAEPPSKRRRFGREPTGRKKTKFVALKKIYVTSSPLRIQNELELLHDLRGCGSVCPLITAFRYQDQVVAVLPYFPHTDFRIQYRTFMVADMRHYLRSLLTALNSVHEHEILHRDIKPTNFLYNPDLKEGVLVDFGLAERQGSEYTNPCLCTHQSYVRRSRILSSYYSKNPPSTGFSAGYPKNDSRPSRRANRAGTRGFRAPEVLLKCTSQTTKIDMWSVGVILLTLLGRRFPFFNSADDIDAMIEMSSIFGTKRMKTAAAMHGQIFETNIPTIGEKGYSWEKLVKWSSCVEDLTESEQQATRLLSGLMELEPSKRLSAADALEHEFFTDPVHHDVPWGGNPEESAESGEEEEADDADEVAML</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W6QEG5</accession>
    <name>W6QEG5_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="24">Self-sufficient cytochrome P450 monooxygenase CYP505E4</fullName>
            <ecNumber evidence="5">1.14.14.1</ecNumber>
            <ecNumber evidence="17">1.6.2.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="25">Bifunctional cytochrome P450/NADPH--P450 reductase CYP505E4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="28" type="ORF">PROQFM164_S03g001582</name>
    </gene>
    <organism evidence="28 29">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="28" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="28">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>2 oxidized [cytochrome P450] + NADPH = 2 reduced [cytochrome P450] + NADP(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24040"/>
            <dbReference type="Rhea" id="RHEA-COMP:14627"/>
            <dbReference type="Rhea" id="RHEA-COMP:14628"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:55376"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="EC" id="1.6.2.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>an organic molecule + reduced [NADPH--hemoprotein reductase] + O2 = an alcohol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17149"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:142491"/>
            <dbReference type="EC" id="1.14.14.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>dodecan-1-ol + reduced [NADPH--hemoprotein reductase] + O2 = 1,4-dodecanediol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:76763"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:28878"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:195422"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:76764"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>dodecan-1-ol + reduced [NADPH--hemoprotein reductase] + O2 = 1,5-dodecanediol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:76759"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:28878"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:195414"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:76760"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>dodecan-1-ol + reduced [NADPH--hemoprotein reductase] + O2 = 1,6-dodecanediol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:76779"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:28878"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:195445"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:76780"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>dodecanoate + reduced [NADPH--hemoprotein reductase] + O2 = 5-hydroxydodecanoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:76723"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:18262"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:195418"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:76724"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 26">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="27">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the N-terminal section; belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.14.1" evidence="5"/>
    <dbReference type="EC" id="1.6.2.4" evidence="17"/>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QEG5"/>
    <dbReference type="STRING" id="1365484.W6QEG5"/>
    <dbReference type="OMA" id="VAPGFNI"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003958">
        <property type="term" value="F:NADPH-hemoprotein reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000040">
        <property type="entry name" value="Bifunctional cytochrome P450/NADPH--P450 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24303:SF31">
        <property type="entry name" value="CYTOCHROME P450 307A1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24303">
        <property type="entry name" value="HEME-BINDING MONOOXYGENASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0249">Electron transport</keyword>
    <keyword evidence="11" id="KW-0274">FAD</keyword>
    <keyword evidence="8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-0288">FMN</keyword>
    <keyword evidence="7 26 27" id="KW-0349">Heme</keyword>
    <keyword evidence="15 26 27" id="KW-0408">Iron</keyword>
    <keyword evidence="10 26 27" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16 27" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="12" id="KW-0521">NADP</keyword>
    <keyword evidence="14 27" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="binding site" description="axial binding residue" evidence="26">
        <location>
            <position position="403"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00047827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00049342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00050670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00050725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00051516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00052652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00069187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00081991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="EMBL" id="CDM34855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="456" mass="51148" checksum="0FF0A2D14899DDA7" modified="2014-04-16" version="1">MPTNIPGPPGVPLLGNVFDVNPNETWNSLNKLAKQFGSIFKINALGHEIVFIGSVALLEEICDQTRFRKCVTGPVVEIRYAVHDSLFTAYDYEKSWGIAHRIMMPHLTQSATDNLFGDMAEVIPDLTKKWSAGTKTRTLLTKDLDRLLLASCMQCFFNQRVHVLEGAEPPMLSAMDGATLEAMKRPTRPKLLNWLVYQRRFEKDTRTMRDFAAQVIKTRKEQPETARKDILDAMMNGADPESGEKLSESQIIDEIISIFIGAATAPNLVSYALYYLMENPSEITKAQEEIDRVVGDGNIDLEHLQSLNYVEAILRESIRLSATAPGFNIEPIPSDDKSPVLLAGGEYQIAHNQPMIAVLSQVNRDPAVFEDPEAFKPERVLGEKWDQLPAAAKKGFGNGKRECIGKLWAWRWSFFTLASILKENTFELANPKYKLESNGAFSIKPLELYGLVSPRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W6QEG7</accession>
    <name>W6QEG7_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Aldolase-type TIM barrel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S01g001793</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QEG7"/>
    <dbReference type="STRING" id="1365484.W6QEG7"/>
    <dbReference type="OMA" id="AINAHCV"/>
    <dbReference type="OrthoDB" id="197068at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003855">
        <property type="term" value="F:3-dehydroquinate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00502">
        <property type="entry name" value="DHQase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000135">
        <property type="entry name" value="Pentafunctional AROM polypeptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10860">
        <property type="entry name" value="Leucine Dehydrogenase, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001381">
        <property type="entry name" value="DHquinase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050068">
        <property type="entry name" value="MurA_subfamily"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01093">
        <property type="entry name" value="aroD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43783">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE 1-CARBOXYVINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43783:SF1">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE 1-CARBOXYVINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01487">
        <property type="entry name" value="DHquinase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM27982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="717" mass="77784" checksum="A83B07A115959BA8" modified="2014-04-16" version="1">MIPTAFPQHMATPLLDDPPISAALKAQAPPSANPNIAVPFNAATIVPPATMATEPEDQTVASIAAPAAATAVRTVVIIYGQNQEHIVQLVAEILGKPWTTDESLGMLARASNALVVGILAHDLARSLQGCERSSLVLVNTYCVEDGSAPEDALTESCDYEFLYSRSPFLRRDLARFLSLILGQTRPHDDLRTKTRTNFISTTFPDVHAALPNLDILSVGSDAVEIRVDLLVEPVPEGSTAPLVPSLKYVGQQLMLLRQHTELPIIFTVRCTRENGKFPVDDPALCYRYLRRAIQWGVEYIDVEVWLPEDIRRQLFEAKGHSMILSAFHDMSGTWKWTSEEAQRIFTESAKYADIVKMIAMVHTIEENYELEYFRSTIKSRGSGPPLSAVNMGQMGQLSRALNTVFSPITHPLLPMIAAPGQLTAAEINEALHIMGQLPKRELYAIGSFRSTPHSMFMEKCINELGLPHNFTSVDLGPKGSMESVLLQPHFGGAYVNPPVPTTTSFIPAVSDAARAIGLVDTIAMTPDETAVGTCRLIGENAAWKGIRATLTREYVPSAYSGRAAIILASSQADASAAIFALRSLAVGAIYTVGFKASGPLAAGLEPFTSIQSVKRVEQPFVIVSALPPEKSLLVQPLLRHYGVNGRSSPPSTRGKVYLDLTSGTRKGDPLAVATSAGWTAYGVEDVSAWTTVETLRLLVGQNVPFDFVRMASGRPLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>W6QEJ2</accession>
    <name>W6QEJ2_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S04</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S04g000034</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QEJ2"/>
    <dbReference type="OrthoDB" id="5424209at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM35153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="70" mass="7918" checksum="25CE97C99A2DEBB8" modified="2014-04-16" version="1">MPALEQRISPLYPEIEAIMSRHNLNVTSTFQCGKMSKPNYPGGDIPLNFFCISTETTQKRESLPKDTEKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>W6QES9</accession>
    <name>W6QES9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S04</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S04g000104</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QES9"/>
    <dbReference type="OrthoDB" id="425534at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM35223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="61" mass="6873" checksum="B3E3B42CC29BC86A" modified="2014-04-16" version="1">MYSGYWTANVVDTDKIIEEFFEICYQAGPEKCSFAAGNTVERTRDTLDKTLASLNKTITKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W6QF63</accession>
    <name>W6QF63_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF3669 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S04g000011</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QF63"/>
    <dbReference type="STRING" id="1365484.W6QF63"/>
    <dbReference type="OMA" id="NLTNIAC"/>
    <dbReference type="OrthoDB" id="2993351at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022137">
        <property type="entry name" value="Znf_prot_DUF3669"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40780">
        <property type="entry name" value="DUF3669 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40780:SF2">
        <property type="entry name" value="DUF3669 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12417">
        <property type="entry name" value="DUF3669"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3669" evidence="2">
        <location>
            <begin position="316"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM35130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="420" mass="47614" checksum="D79FB0041ACC427F" modified="2014-04-16" version="1">MSAHLREISENSVASNDTELSEDARLARATEEMLAVTDAATQDQDILRRTLSVHSVISSSLSFAERMQRAKWFQSAALVVIGRGTCGTVFEIPGTKSAYKKGSDKHSLWNDANLTNIACRAVTETKTSLQEIFPNVSIPRVPEVTGWISQNDLENWWLQNLSRFPDDTQTGYIFQVQRILPLPKPSREALIRLYFPKKLRRSAYQDPDNKACLVRPYLGQRRGEWEFSSPVLSLQNFPLYLDQIEELQLEATQFSEEMAVGLAIIHWRAFLDGMDMEFVLGSATADGELPTVVENFKTVKPFETPAGDFKRRQVHLWMLDFDKADQLNLKESWKSCCDKMVTAVTANDPYFPNPAATGTLEHKLWDTFEHAYLLAASNLLHIQRGLPKKANKYPALFLKAWEKKATELAKDTEGNFVEFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W6QFC2</accession>
    <name>W6QFC2_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S04</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S04g000364</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QFC2"/>
    <dbReference type="STRING" id="1365484.W6QFC2"/>
    <dbReference type="OMA" id="TFTHWSE"/>
    <dbReference type="OrthoDB" id="4991875at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004879789" evidence="1">
        <location>
            <begin position="18"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM35483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="200" mass="20553" checksum="E36009D77CED94CB" modified="2014-04-16" version="1">MRISLFLATALAALVTADETTRINYFGGGMEWVRQLNLHPWTSTAASVAGINAVATTYRIGCLSDAPKSDCEIATPWTMIQGPKTYSLTGVYTVSGSGSINAVTGTHNFDCTFAKVTESPSCSFSVKVTGTTAGVSYSTSTSTSIKNMPTQSYTSYGIDVTAGTALFTASQATKTPNGAAAMITAAPMGAAAVVAIAAML</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W6QFK2</accession>
    <name>W6QFK2_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Pseudouridine synthase I, TruA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PROQFM164_S01g002193</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the tRNA pseudouridine synthase TruA family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QFK2"/>
    <dbReference type="STRING" id="1365484.W6QFK2"/>
    <dbReference type="OMA" id="SCRERRY"/>
    <dbReference type="OrthoDB" id="25767at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990481">
        <property type="term" value="P:mRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.660">
        <property type="entry name" value="Pseudouridine synthase I, catalytic domain, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.580">
        <property type="entry name" value="Pseudouridine synthase I, catalytic domain, N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00171">
        <property type="entry name" value="TruA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001406">
        <property type="entry name" value="PsdUridine_synth_TruA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020097">
        <property type="entry name" value="PsdUridine_synth_TruA_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020095">
        <property type="entry name" value="PsdUridine_synth_TruA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020094">
        <property type="entry name" value="TruA/RsuA/RluB/E/F_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142:SF5">
        <property type="entry name" value="TRNA PSEUDOURIDINE(38_39) SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01416">
        <property type="entry name" value="PseudoU_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Pseudouridine synthase I TruA alpha/beta" evidence="5">
        <location>
            <begin position="364"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="103"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="106"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDM28382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="651" mass="72927" checksum="FBB159EA6ACEEB29" modified="2014-04-16" version="1">MWRVSARLFPLSCNIQHALRQARYLCQSRTLTSQTMEDTKSKGQPDYSAWSNSSLIARITELERQLSSKTTEFTAPTEESLQTPCSSSAPIATDVHEAAIPLTEPFNPSTKRPHSPQDSDSTPVLAPTRLVKAPKPPRPERSFDPSKYTTRFIALKFAYLGQAYNGLEHTNGNTTPLPTVEEIMWKALRRTKLISPGTTSDLEPTERGERVPMRPYHLYWDGCDYSKAGRTDKGVSAFGQVIGLRVRSQRPMPKTPTEGEDAMRVDSGSTEKEWDDVADEMNYINVLNRVLPEDIRVLAWCPNPPPGFDARFSCRERRYKYFFTNPAFAPTPGPLGFQNRAENGNGPRAEFREGWLDIEAMREAAKHFEGMHDFRNFCKLDTNKQIDNFERIILHSSIEAVNPKVNPVGYVGQPGFQAKEGCVPEPDLTTPNTVSQSIPQVYSFNLHGSAFLWHQVRHMVAILFLVGQGFESPSIVPELLDITKNPQKPIYAMADDAPLVLWDCIFPDLNSDSRQDSLNWVYAGDNAANCKGTAKGDSKFGLRGTVESLWAVWRKRKIDEILAGALLDLTVSQGDQNVENLDKQWQKAGYSKRGHRGAKVWCGGNDTVVGGKYIRVDQKGKMETVEVQNAKGLLTKQRRLARMEGAQAASE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>W6QFQ9</accession>
    <name>W6QFQ9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Heat shock protein 90 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">MOD-E</name>
        <name evidence="10" type="ORF">PROQFM164_S04g000539</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the heat shock protein 90 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QFQ9"/>
    <dbReference type="STRING" id="1365484.W6QFQ9"/>
    <dbReference type="OMA" id="MRRMKEM"/>
    <dbReference type="OrthoDB" id="28737at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16927">
        <property type="entry name" value="HATPase_Hsp90-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.790:FF:000001">
        <property type="entry name" value="Heat shock protein 90 alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.80:FF:000001">
        <property type="entry name" value="Heat shock protein 90 alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11260:FF:000001">
        <property type="entry name" value="Heat shock protein 90 alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000001">
        <property type="entry name" value="Heat shock protein HSP 90-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.790">
        <property type="entry name" value="Heat shock protein 90, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00505">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019805">
        <property type="entry name" value="Heat_shock_protein_90_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037196">
        <property type="entry name" value="HSP90_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001404">
        <property type="entry name" value="Hsp90_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020575">
        <property type="entry name" value="Hsp90_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003555">
        <property type="entry name" value="PRK05218.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11528">
        <property type="entry name" value="HEAT SHOCK PROTEIN 90 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13589">
        <property type="entry name" value="HATPase_c_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00183">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002583">
        <property type="entry name" value="Hsp90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00775">
        <property type="entry name" value="HEATSHOCK90"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110942">
        <property type="entry name" value="HSP90 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00298">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="Histidine kinase/HSP90-like ATPase" evidence="9">
        <location>
            <begin position="25"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="213"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="678"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="214"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="678"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="98"/>
            <end position="99"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="118"/>
            <end position="123"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="373"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR002583-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDM35658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="698" mass="79589" checksum="60C8B3CCA96F71A6" modified="2014-04-16" version="1">MSETFEFQAEISQLLSLIINTVYSNKEIFLRELISNASDALDKIRYEALSDPSKLDSNKDLRIDIIPDLVNKTLTIRDTGIGMTKADLINNLGTIARSGTKQFMEALSAGADISMIGQFGVGFYSAYLVADRVTFVSKHNDDEQYIWESAAGGTFTLKEDTEGEQLGRGSKIILHLKDEQLDYLNEARIKEVVRKHSEFISYPIYLHVLKETETEVPDEDAEETKEEDEEKKPKVEEVDDEEEKKEKKKTKTIKESKVEEEELNKTKPIWTRNPADITNEEYASFYKSLSNDWEDHLAVKHFSVEGQLEFRAILFVPKRAPFDLFETKKTKNNIKLYVRRVFITDDCTDLIPEWLSFIRGVVDSEDLPLNLSRETLQQNKIMKVIRKNIVKKTLELFVEISEDREMFDKFYAAFSKNIKLGIHEDAQNRPILAKLLRYQSTKSGDEMTSLADYITRMPEHQKNMYYITGESLKAVANSPFLDTLKQKNFEVLFLVDPIDEYAFTQLKEYDGKKLVDITKDFELEETEEEKTEREAEEKEFEGLAKALKNVLGDKVEKVVVSSKLVGSPCAIRTGQFGWSANMERIMKAQALRDTSMSSYMSSKKTFEISPKSPIIKELKKKVDADGENDRTVKSITQLLFETSLLVSGFTIEEPASFAERIHKLVSLGLNIDEDEAAPAAEVAAPAEATGESTMEEVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W6QFR2</accession>
    <name>W6QFR2_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF962 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S02g003175</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM33024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QFR2"/>
    <dbReference type="OMA" id="IQFIGHY"/>
    <dbReference type="OrthoDB" id="2124888at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046521">
        <property type="term" value="P:sphingoid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009305">
        <property type="entry name" value="Mpo1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28026:SF9">
        <property type="entry name" value="2-HYDROXY-PALMITIC ACID DIOXYGENASE MPO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28026">
        <property type="entry name" value="DUF962 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_8G05310)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06127">
        <property type="entry name" value="Mpo1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM33024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="192" mass="21270" checksum="E1585AA3E8FBBF61" modified="2014-04-16" version="1">MALNLEKQLLFYGAYHSNPVNVAIHITCVPILLFTGIVLACNCPPLFTLPDIIRIEYLPANAGTIGALIYATFYILLEPIAGGLLAPALISAAYYGNYFLGTYGSTVNYWAGGIHVVSWLAQFVGHGVFEKRAPALLDNLVQALLLAPLFVWMEVLFFFGYRPQLKERFEKGVELEILKFRKQGKGKGKAEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W6QFT1</accession>
    <name>W6QFT1_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nucleotide-binding, alpha-beta plait</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S04g000559</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QFT1"/>
    <dbReference type="STRING" id="1365484.W6QFT1"/>
    <dbReference type="OMA" id="RAKEECQ"/>
    <dbReference type="OrthoDB" id="6159137at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000343">
        <property type="entry name" value="RNA-binding domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15241:SF370">
        <property type="entry name" value="SERINE_ARGININE-RICH SPLICING FACTOR SR45A-LIKE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15241">
        <property type="entry name" value="TRANSFORMER-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="68"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="140"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="7"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="44"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="182"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="199"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="234"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="244"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="264"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="334"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM35678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="354" mass="38282" checksum="7C3C2ED4800C0797" modified="2014-04-16" version="1">MADYDNDSSRYADEPRYDRERSASPRDEPRADRDRARSRSPNGRSDDRAPLARKPVEEDDEGAINSGSNLFVTGIHPRLTESDISRLFEKYGDVDNCSIMLDPHTKESRGFGFVNMVTAEQADAAKEGLQGEVIEGRTLSIEKARRARPRTPTPGKYFGPPKRDGPGGPPGGPGGGSRGGGPRRDRYDDRRGPSGGGWRRRDDDYSRYGRYDSYNDRRDYGRDYGRDYGRRDYAGGGGGGGREYGGRRESRDDYAYRGGGDRYGGGRDDRYSRDERRGGAEESRGSGGGGAGYYDRDANPPSFDAAAPPREARDPYAGGGGRSYEGQARSSTGGAPGGGGGSGGGAGEDRYAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W6QFW5</accession>
    <name>W6QFW5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Gpi16 subunit, GPI transamidase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S04g000161</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QFW5"/>
    <dbReference type="STRING" id="1365484.W6QFW5"/>
    <dbReference type="OMA" id="NHGHYIG"/>
    <dbReference type="OrthoDB" id="331263at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042765">
        <property type="term" value="C:GPI-anchor transamidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016255">
        <property type="term" value="P:attachment of GPI anchor to protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007245">
        <property type="entry name" value="PIG-T"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12959:SF11">
        <property type="entry name" value="GPI TRANSAMIDASE COMPONENT PIG-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12959">
        <property type="entry name" value="GPI TRANSAMIDASE COMPONENT PIG-T-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04113">
        <property type="entry name" value="Gpi16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004882000" evidence="2">
        <location>
            <begin position="26"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="536"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM35280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="598" mass="66415" checksum="E4FCE870A4543CAC" modified="2014-04-16" version="1">MTVLSLFSLPFVALILSLWSSSAFASSDYHEHLLLQPLPQSSLLASFNFRSNTSQQSFDQQHFRYLPRALGQILQHAHTKELHLRFTTGRWDAESWGTRPWNGSKEGGTGVELWAWIDAPDDEEAFAKWITLTQSLSGLFCASLNFVDSTRTTRPVVSFEPAGDHSAADQLHLLHGTLPGEVVCTENLTPFLKLLPCKGKAGISSLFDGHKLFDAAWQSMSVDIQPVCSADGECVVQIEQTVDMVLDIDRSKRSRSNPIPRPVPNEQLVCDTSKPYNSDDTCYPVEKTSEKAWSLAEIFGRSLNGVCPLTDFDGSSDQSVCLRVPHERGVFISEEANEIKKDDGFTRCFKLAPSVPFDLSIPQQPANTEVPLDEPVLHAERTIVGHGQERGGMRIIFGNPSNTSAVDFIYFESLPWFLRPYIHTLHATITGHDGVLREVPASEIVKETYYRPAIDRERGTQLELALSVPAASTVTLTYDFEKAILRYTEYPPDANRGFNVAPAVIRILDTAHNVPIYIRSTSLLLQLPTPDFSMPYNVIILTSTVIALAFGTIFNILVRRVVSLDEAAALGAQTLKGRILGKLVAIRDRLRGKDTKMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W6QGJ4</accession>
    <name>W6QGJ4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Pyruvate carboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PROQFM164_S04g000829</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM164</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QGJ4"/>
    <dbReference type="STRING" id="1365484.W6QGJ4"/>
    <dbReference type="OMA" id="KGDAWSI"/>
    <dbReference type="OrthoDB" id="196847at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06850">
        <property type="entry name" value="biotinyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000003">
        <property type="entry name" value="acetyl-CoA carboxylase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CPAse_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45007">
        <property type="entry name" value="CARBOXYLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G07570)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45007:SF1">
        <property type="entry name" value="CARBOXYLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G07570)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="Rudiment single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0092">Biotin</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="9">
        <location>
            <begin position="8"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="8">
        <location>
            <begin position="127"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoyl-binding" evidence="7">
        <location>
            <begin position="574"/>
            <end position="654"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDM35948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="666" mass="73064" checksum="35C5D8EC31862789" modified="2014-04-16" version="1">MSSPHSRPIKRLLVANRGEIAVRILHAARELPSSVETFALYTSDDRPHCDLGRPQHAIEIPSASSYLDISLLVDLVQKNSIDAVHPGYGFLSESAEFAHRMWHEAGALVIGPGWENLARTGDKLQAKQLAQQCGVPVLEAMSQPTTNVDEARAFATQVGFPVMIKAVDGGGGRGIRLVREEHELDNSIQRAIGESPSRTVFVEKAAVDGFHHIEIQIIGDGTGQVRHLWERDCSAQRRFQKVVECAPALMRDRALVGRVIESALRMASEIRYQSLGTFEFLVSEQRGEFYFLEVNPRLQVEHTITESISGIDLVQTQLLLAQGYTLRDLGLGAEIDPSHLPPNAFSVQLRLCAEDPSNGFSLSIGKVTRFTVPSGNGIRVDTHVNVSGPALVVGSNFDNLLAKIIVTAPTWEASVRKAQRVLADSRVDGLKTNISLLRGIVAHSDFMAGKVDTQWLGLNIDAVLQQGEMISKTIQGLDGSAGPSQQVSQNGLPVSNLLFRKGDAWSITLEPLSKDSQSDKVSHHLRLSRVLRNEFPTALAAEIEYTTPTSEGAIPYRMQLETTTTAASALVSSSHRRGDPKNPHHIILPLSGKLIEILVSDGQDVVENQVLAFVKQMKMELEVRSPRSGRVKWVHEMEDEEEDVAEGMLLVELEPNNGKVEVRGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W6QGM3</accession>
    <name>W6QGM3_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type DNA-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PROQFM164_S03g000053</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QGM3"/>
    <dbReference type="STRING" id="1365484.W6QGM3"/>
    <dbReference type="OMA" id="CLLWWNL"/>
    <dbReference type="OrthoDB" id="39175at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF11">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="51"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="28"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="34"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM33329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="654" mass="73862" checksum="B9EC63C4792BD1EF" modified="2014-04-16" version="1">MPRYLSLMFPPLSAKNIPNNFALRRMENTEKSTPQKKRQNPNRCRPKSKGGCQRCKQRRRRCDEAKPSCQECTKRGHTCPGYQKQSLQWRYVFKGSEEPKQPAAQIESPETVATELFEVNNPTQDERDNLQNGTPSIWDTTCSNLFDQLPDFDEPTDAWSYTELRSNDTGLTNPDAELDGLSVLRQRLVNTSVPSFLIQLPVMLVQYYFHTVCNQWSSFDCPLNPFRTIVSRLWSRNAAIYFAIQSMSAASLANDFPNMRPIGIQTQQQAIACLNTSAQKSSVQAKDDEYFLALLMIGSTTGWHDASDLGLPYLRAAQDHLMRQERQCKNANSALAKQHPLFKQCLLWWNLLAAFVAEESPIVDVESSIENSDTDLSVYLVDGQILPHPWTGSFRYALSLFYRTARVIRAARTSHRRRPEALDPTLIDLSSMAEELDLRQKAEHLEDKILFTGFSFYCGPVDIGDTNTPPSHFLTLAEAYRCTALLQIYHVFPDILEDRLRSNQTTDGESPIPALFLLLFPIATEWSSCSVEDTRHTLALHIVSLLGQLPSTSGTKVLQPVVLACISSDLVFSSGSVLGATGNSITSLNTLDVEIAQARRKVKMRLSELILILPKLPMQRIVNVVHETWDRADSGVEEFWLDIMMDLNLETIMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W6QHD2</accession>
    <name>W6QHD2_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">chitinase</fullName>
            <ecNumber evidence="4">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">PROQFM164_S04g000706</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">GPI-anchored chitinase involved in the degradation of chitin, a component of the cell walls of fungi and exoskeletal elements of some animals (including worms and arthropods). Required to reshape the cell wall at the sites where cell wall remodeling and/or cell wall maturation actively take place such as sites of conidia formation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="19">Belongs to the glycosyl hydrolase 18 family. Chitinase class III subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="4"/>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QHD2"/>
    <dbReference type="STRING" id="1365484.W6QHD2"/>
    <dbReference type="OMA" id="TNYADYM"/>
    <dbReference type="OrthoDB" id="6020543at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02877">
        <property type="entry name" value="GH18_hevamine_XipI_class_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000150">
        <property type="entry name" value="Class III chitinase ChiA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045321">
        <property type="entry name" value="Cts1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050542">
        <property type="entry name" value="Glycosyl_Hydrlase18_Chitinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45708">
        <property type="entry name" value="ENDOCHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45708:SF47">
        <property type="entry name" value="ENDOCHITINASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0134">Cell wall</keyword>
    <keyword evidence="11" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="8" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="16" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="10 23" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="9 21" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="21">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004881622" description="chitinase" evidence="21">
        <location>
            <begin position="22"/>
            <end position="1192"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="22">
        <location>
            <begin position="28"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="340"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="672"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1064"/>
            <end position="1130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="349"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="672"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="20">
        <location>
            <begin position="727"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="750"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="788"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="814"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="838"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="858"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="879"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="20">
        <location>
            <begin position="1070"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="1086"/>
            <end position="1112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00024658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00025727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="CDM35825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="1192" mass="116795" checksum="86F8ECAFE1E08F91" modified="2014-04-16" version="1">MMFKSFAAVSALSLFASSAVALDASLKNNVAVYYGQGFNQPRLSHFCEQTTSDIINIGFIDQFPKFVGDFPGSNFANQCDGNFFPGTELLNGCHQIWQDIPICKAAGKTILLSIGGGTATAQSLPDEATATWFADFLWYSFGPYNPSISSLGWTEDLVGIFPRPFLTSSVDGFDFDIEYNGGVGYATLINRLRSHFETSGETYYISGAPQCPIPDPQLGDAITNSYFDFIWVQWYNTQGCSAADWVHKTGKFNFDDWVGVIEKSVNPNAKLFIGLPASEDAANAGFYLTPDEVQPLVETYMDKHPDHFGGIMLWEATAGENNLINGTTFTEHIKDILYGCAPPPPPPTSTVTPIPSSTVTPVSSSTVPPSSSATPSVTSVASSSVASSSSVVSSSSVVSSTSAASSSSVASSTSVASSSSATPSATSVASSSVASSSSVASSSSVASSSSVASSTSVVSSTSVASSSSVASSSVASSSSVASSSVASSSSVASSTSVASSSSVASSTSVVSSTSVASSSSVASSSVASSSSVASSSVASSSSVASSTSVASSSSVASSTSVVSSTSVASSSSVASSSVASSSSVASSSVASSSSVASSTSVASSSSVASSTSVVSSTSVASSSSATPSATSVASSSVASSSSVASSSSVASSTSVASSSSVASSSVASSSSVASSSSVASSSSVSSTTPATSEQSSSTSSLPSSSVTTTPASSGHPAPHSSATGKPHSSHAGHGHGHGHGHHTHTHLHPHTVPSSTPLIPGHPSSTAPISSATESSASSTSEGVIPTGVSSTSDETTGSSKPTSIETTGASKPTGDNTTGGSSSTGVETTGGSKPTGDKSTGGSKPTSVETSGDSKPTGDNTTGGSSSTSVETTGGSKPTGNNFTGGSKPTGTDSTTAPAGITATASVTASPSSLAPGTTTTIIVTSYVDICPTGFTTITTTITKTYCPGDVSATATPTGTAEITAPTSGPATSTPYIPEGWTTTVTVCTQCAATPTTVTLTKPAATTTTEVVSQPTAPSVPEEYTTTVTFCKHCGPTGSTVTITIPAPTVTATATATATATATSIVPGSGSGSSGNGEGSGSGSSSGSTGEVTVPGVAPVSPSSSSKPIPSHGAGGFHVGKPSSSIAFRPSPARTAVPAVPTVATTATNTPALPTNQEGVSPVYTGAASRSNMTGLFGGVLAIALSMFMML</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W6QHI2</accession>
    <name>W6QHI2_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S04</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S04g000771</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QHI2"/>
    <dbReference type="OMA" id="YTCGHSA"/>
    <dbReference type="OrthoDB" id="4500639at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM35890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="75" mass="8592" checksum="70F702D97FE10267" modified="2014-04-16" version="1">MSYNPPGDFIVPDINTQEVCTQLQIRYACGHSTGGEFVKCPRHVKKEDERCTSRQINHVDVKNSSHKCRLCLRSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W6QHN9</accession>
    <name>W6QHN9_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Indoleamine 2,3-dioxygenase</fullName>
            <ecNumber evidence="5">1.13.11.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PROQFM164_S01g002939</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Produces N-formyl-kynurenine through the oxidation of tryptophan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-tryptophan + O2 = N-formyl-L-kynurenine</text>
            <dbReference type="Rhea" id="RHEA:24536"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:58629"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the indoleamine 2,3-dioxygenase family.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.52" evidence="5"/>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QHN9"/>
    <dbReference type="STRING" id="1365484.W6QHN9"/>
    <dbReference type="OMA" id="TYELGPA"/>
    <dbReference type="OrthoDB" id="10262710at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033754">
        <property type="term" value="F:indoleamine 2,3-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:L-tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.480:FF:000005">
        <property type="entry name" value="Indoleamine 2,3-dioxygenase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000898">
        <property type="entry name" value="Indolamine_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037217">
        <property type="entry name" value="Trp/Indoleamine_2_3_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28657">
        <property type="entry name" value="INDOLEAMINE 2,3-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28657:SF3">
        <property type="entry name" value="INDOLEAMINE 2,3-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01231">
        <property type="entry name" value="IDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140959">
        <property type="entry name" value="Indolic compounds 2,3-dioxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="4 5" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="proximal binding residue" evidence="4">
        <location>
            <position position="400"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600898-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU369119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDM29127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="496" mass="56240" checksum="CC0C2DA113CD60C5" modified="2014-04-16" version="1">MTRTQVPYPSPTTLRRFPHIHDDPSSISHSLDPFTITTKTGFLPYETAPVELPEAFGALLSLVNRLPVVRLDGKPGLLATYELGPAVKAELTDLTDEVEKLVVADGSPDRFTIAAVFRDYTFLASSYLLEPCWEHWNKDPAGGYGLGRDVLPQSIARPMYRCAEILNLPPFMSYAASYALFNYTFADPAKGPSEYSNLRLIRSFERGLDPKSSEAGFILTHVDMVKETGPLIAGVLKIVDNLEQHGSRQDINDGFREILKSMEKIEASMEDMWGNSKPSEYLSFRVFIFGITNQSMFPNGVIYEGCEDNKPLYFRGESGANDSIIPLLDHLCEIPMPETPLTKILHEFRAYRPLPHREFLTYIREKSEEIGVQNYAIQDSETAVLFLRTLNHIRSFRWRHWLFAREYIIRRTPHPTATGGSPIVTWLPNQLSAVMELMVKISDENLAPKDGVVTLNGSEDLVASHRKQVEPMMELVRDQKEKLAKEVERWCQERGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W6QHU1</accession>
    <name>W6QHU1_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein kinase-like domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S04g000881</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM36000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QHU1"/>
    <dbReference type="STRING" id="1365484.W6QHU1"/>
    <dbReference type="OMA" id="KEKRCHY"/>
    <dbReference type="OrthoDB" id="8300194at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05120">
        <property type="entry name" value="APH_ChoK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF55">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="33"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM36000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="275" mass="31580" checksum="EDD92AF22F01E72F" modified="2014-04-16" version="1">MGEPSVEGCIACGWTSTKQKQCHYSSHLRLFYGASQRGVWTIGSDVILKDRLDEGLKAKVEVKTLNYLATHIDIPVPKVLRDWVDYDGRYFVMTERIRGQTLEEAWPSLSEPQKVAITDQVVEVRKQLRSVTSPSIECVDHSPCYPTLLFFNLEPHGPFHSDQELWDALSLDLHHLPLKVLDNLKKRRPKCEPYVLTHCDLNLGNIMIQDGKVISILDWEYAAYLPIWYEYVAASFGFTVMDVEWKKLLQERLDVHDEGHEDAKALRHFGGICVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W6QIR5</accession>
    <name>W6QIR5_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mannose-1-phosphate guanyltransferase</fullName>
            <ecNumber evidence="4">2.7.7.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">GDP-mannose pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">GTP-mannose-1-phosphate guanylyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">mpg1</name>
        <name evidence="18" type="ORF">PROQFM164_S05g000541</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Involved in cell wall synthesis where it is required for glycosylation. Involved in cell cycle progression through cell-size checkpoint.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>alpha-D-mannose 1-phosphate + GTP + H(+) = GDP-alpha-D-mannose + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15229"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
            <dbReference type="EC" id="2.7.7.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; GDP-alpha-D-mannose from alpha-D-mannose 1-phosphate (GTP route): step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.13" evidence="4"/>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QIR5"/>
    <dbReference type="STRING" id="1365484.W6QIR5"/>
    <dbReference type="OMA" id="GPNCWIC"/>
    <dbReference type="OrthoDB" id="1733332at2759"/>
    <dbReference type="UniPathway" id="UPA00126">
        <property type="reaction ID" value="UER00930"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004475">
        <property type="term" value="F:mannose-1-phosphate guanylyltransferase (GTP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071554">
        <property type="term" value="P:cell wall organization or biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009298">
        <property type="term" value="P:GDP-mannose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05824">
        <property type="entry name" value="LbH_M1P_guanylylT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06425">
        <property type="entry name" value="M1P_guanylylT_B_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.10.10:FF:000017">
        <property type="entry name" value="Mannose-1-phosphate guanyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000013">
        <property type="entry name" value="mannose-1-phosphate guanyltransferase beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056729">
        <property type="entry name" value="GMPPB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045233">
        <property type="entry name" value="GMPPB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018357">
        <property type="entry name" value="Hexapep_transf_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050486">
        <property type="entry name" value="Mannose-1P_guanyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22572">
        <property type="entry name" value="SUGAR-1-PHOSPHATE GUANYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25087">
        <property type="entry name" value="GMPPB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00101">
        <property type="entry name" value="HEXAPEP_TRANSFERASES"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 18" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nucleotidyl transferase" evidence="16">
        <location>
            <begin position="2"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="Mannose-1-phosphate guanyltransferase C-terminal" evidence="17">
        <location>
            <begin position="256"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00031190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF25087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CDM36708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="364" mass="40159" checksum="5DD14D2847E77160" modified="2014-04-16" version="1">MKALILVGGFGTRLRPLTLTLPKPLVEFGNRPMILHQVESLAAAGVTDIVLAVNYRPDVMVAALKKYEEQYGVNIEFSVESEPLGTAGPLKLAEEILGKDDSPFFVLNSDVICDYPFKELAEFHKSHGDEGTIVVTKVDEPSKYGVVVHKPNHASRIDRFVEKPVEFVGNRINAGIYILNPSVLKRIELRPTSIEQETFPAICKEGQLHSYDLEGFWMDVGQPKDFLTGTCLYLTSLAKRNPKMLAPHTEPYVYGGNVMVDPTAKIGKNCRIGPNVVIGPNVVVGDGVRLQRCVIMENCKVKDHAWIKSTIVGWNSSVGRWARLENVTVLGDDVTIADEVYVNGGSILPHKSIKQNIDVPAIIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W6QIV7</accession>
    <name>W6QIV7_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Homocysteine S-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PROQFM164_S04g000822</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QIV7"/>
    <dbReference type="STRING" id="1365484.W6QIV7"/>
    <dbReference type="OMA" id="CSQPEVI"/>
    <dbReference type="OrthoDB" id="261426at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008898">
        <property type="term" value="F:S-adenosylmethionine-homocysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033528">
        <property type="term" value="P:S-methylmethionine cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.330:FF:000007">
        <property type="entry name" value="Homocysteine S-methyltransferase (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.330">
        <property type="entry name" value="Homocysteine-binding-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003726">
        <property type="entry name" value="HCY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036589">
        <property type="entry name" value="HCY_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051486">
        <property type="entry name" value="Hcy_S-methyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46015:SF1">
        <property type="entry name" value="HOMOCYSTEINE S-METHYLTRANSFERASE-LIKE ISOFORM 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46015">
        <property type="entry name" value="ZGC:172121"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02574">
        <property type="entry name" value="S-methyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82282">
        <property type="entry name" value="Homocysteine S-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50970">
        <property type="entry name" value="HCY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 5 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Hcy-binding" evidence="6">
        <location>
            <begin position="1"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="327"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="328"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM35941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="345" mass="37388" checksum="DD21ED3857D0FC9C" modified="2014-04-16" version="1">MATIQILDGGLGTSLGDLYNIKFDSTTTPLWASHLLVSDPATLQACQRDFGVAGVDVLLTATYQVSTEGFARTKTAQFPDGIPRSAVGPFLQKAVDIAEQAKVRENASVALSLGPYGACMVPGQEYSGAYDAAHDSEESLYLWHLDRLRMFAEAEGELVSRVRYVAFETLPRLDEIRAVRRAIQDSAFDVPFWISCVFPREDDLLPDGSSVGQVVRAAIAPLEGGAVPWGIGINCTKMHKLAGLVDLFGGAVAECVADGQVSDVPSLVLYPDGTNGEVYNTTTQVWERPDGLRDSVSADRSWEVQLAQVVNEAYEKGYFNSFLVGGCCKASHHDIKKLGEQFKTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W6QIX6</accession>
    <name>W6QIX6_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S05g000188</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QIX6"/>
    <dbReference type="STRING" id="1365484.W6QIX6"/>
    <dbReference type="OrthoDB" id="4367324at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="70"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM36355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="244" mass="27543" checksum="75881BB71E62D814" modified="2014-04-16" version="1">MHEFGPLLRAIRIQRHTIRSPSPQRELTSESDLPLAFGEDLHALIRRSLRCTFEHLDNRAEQRAEPQVDPQAEPQAPSQPEDLLFNQVLDRVLDVLSDGTNILIGVGPDALMLAKFIPDLSIYEAGEASNRNVLSLNRLPGDLKPSWKWSPSMMNSSFIDPEFFKPLAQVNWYMTQHGTQFGFILTDQELVPIQRVDDDGNLKLGAPIPWTQTGTSKEPQLTVALGLWYLGMLTADDTLYRARQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W6QJ22</accession>
    <name>W6QJ22_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">asparaginase</fullName>
            <ecNumber evidence="1">3.5.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PROQFM164_S01g003399</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">In the N-terminal section; belongs to the asparaginase 1 family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.1" evidence="1"/>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QJ22"/>
    <dbReference type="STRING" id="1365484.W6QJ22"/>
    <dbReference type="OMA" id="CDVGVIP"/>
    <dbReference type="OrthoDB" id="542841at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004067">
        <property type="term" value="F:asparaginase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009066">
        <property type="term" value="P:aspartate family amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd08963">
        <property type="entry name" value="L-asparaginase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1170:FF:000003">
        <property type="entry name" value="60 kDa lysophospholipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.40:FF:000001">
        <property type="entry name" value="L-asparaginase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000284">
        <property type="entry name" value="Lysophospholipase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1170">
        <property type="entry name" value="L-asparaginase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036152">
        <property type="entry name" value="Asp/glu_Ase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006034">
        <property type="entry name" value="Asparaginase/glutaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040919">
        <property type="entry name" value="Asparaginase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027473">
        <property type="entry name" value="L-asparaginase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041725">
        <property type="entry name" value="L-asparaginase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027474">
        <property type="entry name" value="L-asparaginase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037152">
        <property type="entry name" value="L-asparaginase_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11707:SF28">
        <property type="entry name" value="60 KDA LYSOPHOSPHOLIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11707">
        <property type="entry name" value="L-ASPARAGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00710">
        <property type="entry name" value="Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17763">
        <property type="entry name" value="Asparaginase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001220">
        <property type="entry name" value="L-ASNase_gatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500176">
        <property type="entry name" value="L_ASNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00139">
        <property type="entry name" value="ASNGLNASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00057">
        <property type="entry name" value="Glutaminase/Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00870">
        <property type="entry name" value="Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53774">
        <property type="entry name" value="Glutaminase/Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51732">
        <property type="entry name" value="ASN_GLN_ASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="L-asparaginase N-terminal" evidence="7">
        <location>
            <begin position="20"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="Asparaginase/glutaminase C-terminal" evidence="8">
        <location>
            <begin position="259"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="440"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00061199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM29587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="553" mass="59904" checksum="E1E14F1E4604EFDF" modified="2014-04-16" version="1">MTLTPTLDPAKAEETSHESRVLIIMTGGTICMQPSPGGFIPARGFQEKCMARVPTFNDGSASTTMNVVANAAHELKARPSLRTPMTAYGRQVRYTVFEFEELLDSSSIDAKGWTQIAEAIERNYKLFDGFVVLHGTDSLAYTCSALSFMLQNLGKPVVLTGSQAPMLELQNDATDNLLGSLVVAGHFMIPEVCLYFNNRLFRGNRTTKVAASDFAAFDSPNCAPVAVTNSMRTNVNWDMVHRPTSLEPFSIRTNLDTTHVACLRIFPGIKPEMVDAVLKLDGLRGLILETFGAGNAPSGQDNAMINVLASAIQRGIVIVNITQCLTGSVSPVYATGMSLSRAGVVAGLDMTTEGALTKLAYLLALPESTPESVAKNMSVSIRGELTESTLPIFRHPDGELSDRIQTLTSLGYAIAQGDLEKVQAITKREHHWLLNDADYSGNTPIHLAATSPSIKILHLLLSQGGSVHLRNRAGHTPLFLAASAGLSEHTLLLRKSGAHLHSDERPAAELMARHRPFVWGMAGVGPKEISQREMEEEWEWDAGKNRMIPGSAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W6QJE6</accession>
    <name>W6QJE6_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Probable transposable element</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PROQFM164_S05g000378</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1365484.W6QJE6"/>
    <dbReference type="OMA" id="HECRETI"/>
    <dbReference type="OrthoDB" id="4159828at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481:SF1">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481">
        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14529">
        <property type="entry name" value="Exo_endo_phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="394"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase" evidence="5">
        <location>
            <begin position="932"/>
            <end position="1193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="21"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="170"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="101"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="43"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="174"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDM36545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="1513" mass="170123" checksum="9EDDF16CC30AAC5E" modified="2014-04-16" version="1">MFRLALGSYRGVQTSQFAALYDEHEKSPPRLLRPRRTTRPRNNYGQEQEIEIQQRNARSQQKKRTRGKPVAQREAVTSDDASTESDDTNAANLVKELVKLRRDIKRRDDSHREEMQKVQEELQKVKEEFSAALAEVQQELQTLAERPLPEPCARNGHDEILREVQSLREEISTPAPASSPSYADVARTPPLSHPSNIRTLSTSNTTPTTFTDTLYCTIDTSKMTESESEKASAGSIRATIETEIRKMDDHTHWRCRAVTVSPRDTNRIRIACRDEAEHQLVKKVAEAKIGAGARVLRDELYPIKVDSVKRTAVLDENHEILTGAAAAMGEENGTTVAKMTWLSNKEIAKPYGSMVVYLTKGTDARRILADGYFHVGGESGTTSVFEYRPRPVQCYNCQEVGHKAFQCKKIQKCAKCATEGHHHSRCDHTVPKTARNSTRHVMNRSLRIIQLNVRKQGAVHESLMNDEDTQNAVALAIQEPQARRIQGRLLTTPMGHHKWTKMVPSTWREGRWAIRSMLWVNRDVEAEQVRIESPDLTAAVIRLPERLVFIASVYVEGGEASALSDACDRLRKAITKVQRDTGTVVEIMITGDFNRHDQLWGGDDVSLSRQDEADPIIDLMNEFALSSLLKRGTMTWHGGGHSGDCESTIDLVLASENLTDSMTKCAILGTDHGSDHDAIETVFDAPWPVPKYQERLLLKNAPWNEINARIASTLAATPSEGTVQQKTDRLMSAVSDAVHNLTPRAKPSPHAKRWWTTDLTQLRHIYTYWRNHARSERRAGRKVPRFERMAQDAAKQYHDAIRKQKKKHWNEFLADNDNIWKAAKYLKSGEDAAFGKLPQLVRADGTTTADHMEQAEELLSKFFPPLPDNIDDEGIRPQREPVEMPAITLEEVERQLLAAKSWKAPGEDGLPAIVWKMTWPTVKYRVLELFQASLAEGSLPRQWRHAKIIPLKKPNKENYTIAKSWRPISLLATLGKILESVVAERFSHAVETHGLLPTSHFGARKQRSAEQALLLLQEQIYTAWRGRRVLSLISFDVKGAYNGVCKERLLQRMKARGIPEGLLRWVEAFCSERTANIQINGQLSEVQSLPQAGLPQGSPLSPILFLFFNADLVQRQIDSQGGAVAFVDDFTAWVTGSTAQSNREGIEAIIREALDWERRSGATFEAEKTAIIHFAPKTRKSDHDPFTIKGQTVVPQDHVKILGLLMDTRLKYKEHIARAASRGLEAAMELRRLRGLTPASARQLFTSTVAPVVDYASNVWMHACKDKAMGPINRVQRVGAQAIVGTFLTVATSVAEAEAHMATAQRRFWKRAVKMWTDIHTLPETNPLRRCTDQIRKFRRYHRSPLYHVADTLKHIDMETLETINPFTLSPWAERVQTDIDEQHESLAEAGGCMQVAVSSSARNELVGFGVAIEKRPPRNRKLKHKALSITLAVRAEQNPFSAELAAMAHVLSTATGLKDYTIALLTSNKAALNMVVGVKDYRIALLTSNKAAALTLRNPRQQSDQCPVDLNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W6QJR7</accession>
    <name>W6QJR7_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transmembrane protein 184 homolog C30D11.06c</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PROQFM164_S03g001188</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QJR7"/>
    <dbReference type="STRING" id="1365484.W6QJR7"/>
    <dbReference type="OMA" id="AFAIAHW"/>
    <dbReference type="OrthoDB" id="5348404at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005178">
        <property type="entry name" value="Ostalpha/TMEM184C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23423">
        <property type="entry name" value="ORGANIC SOLUTE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03619">
        <property type="entry name" value="Solute_trans_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01417">
        <property type="entry name" value="Solute_trans_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="16"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="218"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="361"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="438"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="378"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="448"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="500"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="541"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="567"/>
            <end position="578"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM34464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="589" mass="66243" checksum="2530A05723356C40" modified="2014-04-16" version="1">MTTAAGGGTGSSLARAIIIVTGVSALVSSLLSFVSIWFQTKNYRKPLLQRYVVRILLMVPIYAVSSWTSIISLRAAQFLDPVRDIYEAFTIYTFFQLLINFLGGERAVIIMAHGRPPISHAWPLNHFLPKIDISDPQTFLAVKRGILQYAWLKPILALGSIIMKATDTYQEGYIGLSSGYLWTGIIYNVSVTISLYSLAMFWVCLHDDLAPFRPVPKFLCVKLIIFASYWQGFFLSILQWLGALGSVAGYTPDNLAAAIQDSLICFEMPLFAMAHWYAFSWHDYADPTISAARMPVKYALRDAFGVRDLVEDTKFTIRGKNYGYRLFDSGDNIIPHEESGSRVKRVMAGMRYERGGKAKYWIPEPGEANSRTPLLGGESSQRGPGNKRASQTSRERIRSYSEIDETALDDEDERIFLNARALEYGDWNYPVITANVVPSDQRLPPSRRNQDSNRGADVKKAHRHRKSRASNGESRQSHKPKSKIAGPSSATPGPLKRNVSSTSSSGTQRSQLVDLVVENTEAEEEVRAQTQREYGSAWAEPEPRRFSRPCEDLIEEEAEANSIQPETNHDEDRPKWAYDDLEQDNVWGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W6QJU9</accession>
    <name>W6QJU9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S01g003655</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QJU9"/>
    <dbReference type="STRING" id="1365484.W6QJU9"/>
    <dbReference type="OrthoDB" id="4368961at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM29842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="112" mass="13249" checksum="DA09512BB3C63A6A" modified="2014-04-16" version="1">MTWDHKVDIWSVLACWARNPAELDDGYPLAEMQAVLGSPPLKLLGRSERSHQFWDEKDPLSDFNLEALEERLKDDAKEEFLRFLRRMLCWLPEERASAKLLFDLWLMRGLCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W6QK16</accession>
    <name>W6QK16_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA methylase, N-6 adenine-specific, conserved site</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S05g000169</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MT-A70-like family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QK16"/>
    <dbReference type="STRING" id="1365484.W6QK16"/>
    <dbReference type="OMA" id="EEWVWIK"/>
    <dbReference type="OrthoDB" id="61116at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
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        <property type="entry name" value="MT-A70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12829:SF4">
        <property type="entry name" value="N(6)-ADENINE-SPECIFIC METHYLTRANSFERASE METTL4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="N6-ADENOSINE-METHYLTRANSFERASE"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
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    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="64"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM36336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="519" mass="58346" checksum="B5234D95F76F8E15" modified="2014-04-16" version="1">MRLSSTTTRCTAIHSLFSPSPTNHGKRMTSMSNTIQEETAILFQDKNIYLIDIPHSIALAQEGRPTSQQPTSESLRTEKSTHKNILNLLSCSPIKEPFPSTEPKKPAALANLLNTIPISERRFHSELILPLVRDSLETIKAGCSHDRRWCEARAVPSESPNYDSRMPNQKRRWGNDYICLESADDGVSTQNEPPIILSTTSPNDFEALSDLAIVKNPSPEPAIIRVGSCHRDEADSPPCEYMAPPKSSFVLCTLPLFQTEIYRPSTSNNYPIPGLPHHQKFNLILMDPPWPNKSVRRSGHYQTHHYSEMDVLTKGLRDILRVHSHDPSTKQGLRQETHTEPIQSEQSIAAIWITNAEKARRAAYEALTGAGFCICEEWIWVKTTWDGQPISALDGLWRKPYEILVIGRKGDHSINVNVNANANNATSLSQMDDLTRMSATITTRRVIAAVPDLHSRKPNLKSIFENVFFTDAGRCQEYSALEVFARNLTAGWWAAGNEVLRFNARECWVELGGREYSHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W6QKX1</accession>
    <name>W6QKX1_PENRF</name>
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        <submittedName>
            <fullName evidence="3">Carbohydrate-binding domain family 9-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S06g000055</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792020">
        <property type="protein sequence ID" value="CDM37095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QKX1"/>
    <dbReference type="STRING" id="1365484.W6QKX1"/>
    <dbReference type="OMA" id="ANLFILW"/>
    <dbReference type="OrthoDB" id="19261at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09630">
        <property type="entry name" value="CDH_like_cytochrome"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cellobiose dehydrogenase, cytochrome domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cellobiose_DH-like_cyt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005018">
        <property type="entry name" value="DOMON_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47797:SF1">
        <property type="entry name" value="CYTOCHROME B561 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47797">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G05805)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
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            <end position="207"/>
        </location>
    </feature>
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        <location>
            <begin position="59"/>
            <end position="148"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
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        </source>
    </evidence>
    <sequence length="207" mass="22382" checksum="BA296941040E6305" modified="2014-04-16" version="1">MVRHIFAWLWAIPALAQVHSIHPQGHSEITYSFNVPDNTAESGSGPIYFQMNSTRQVQWFALGQGMQMAGANMFVVYTSGNKVTVSPRSGVGEIEPLYNKDAQITILNGSGVHDGVITANVRCDTCLKWNGGTENVNSPSSPWIWSVKYGEPLNSVSLSEGITQHDDYGVMNVDLKQATGGSSVNPFAQIARVPISPSEDPAFAALQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W6QL67</accession>
    <name>W6QL67_PENRF</name>
    <protein>
        <submittedName>
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        </submittedName>
    </protein>
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    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QL67"/>
    <dbReference type="STRING" id="1365484.W6QL67"/>
    <dbReference type="OMA" id="PKAKMPN"/>
    <dbReference type="OrthoDB" id="4653208at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM34939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="271" mass="29926" checksum="A45BD64E1B670471" modified="2014-04-16" version="1">MNGRHDELSVTLPAHSTWRSAIQAVVAALDDVDESFLVMPRRCGNRRAIREIALQAGTEVNFKGLPIRTNVDLGTVSPRPPRSESVRERLREIAKDAAKMEWRDPYVSLHAGLGDSCLPLIRANITLKGIDGNEQDLTCELEEVEMVFNTGAHRTIITEELLSPAFREYLRDPIHDLYRSPDGIAVQVDSSLALSNSCTSIDAVALILPKAKMPNQLVGILFGQISCIDRLSLRAIPRHVLLARGEGVSDQLWGDILVEEYANLDGELVSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2024-10-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>W6QLG2</accession>
    <name>W6QLG2_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S02g000546</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QLG2"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM30397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="33" mass="3596" checksum="DCD89E54069D04E1" modified="2014-04-16" version="1">MLPDRAVKRAEVPLGRFIVALFSGATIHVSTRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W6QMF3</accession>
    <name>W6QMF3_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PROQFM164_S08g000104</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792022">
        <property type="protein sequence ID" value="CDM38053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1365484.W6QMF3"/>
    <dbReference type="OMA" id="FMIQMKS"/>
    <dbReference type="OrthoDB" id="5408934at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056416">
        <property type="entry name" value="DH_2_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056222">
        <property type="entry name" value="PH_23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056223">
        <property type="entry name" value="PH_24"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24340">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24344">
        <property type="entry name" value="PH_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24345">
        <property type="entry name" value="PH_24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DBL homology" evidence="2">
        <location>
            <begin position="609"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="3">
        <location>
            <begin position="830"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="4">
        <location>
            <begin position="1372"/>
            <end position="1499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="505"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="734"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="981"/>
            <end position="1369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1503"/>
            <end position="1538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1573"/>
            <end position="1594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1634"/>
            <end position="1681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="339"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="390"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="433"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="505"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="741"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1026"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1072"/>
            <end position="1082"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1101"/>
            <end position="1111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1174"/>
            <end position="1183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1193"/>
            <end position="1204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1231"/>
            <end position="1240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1309"/>
            <end position="1319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1324"/>
            <end position="1338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1350"/>
            <end position="1369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1524"/>
            <end position="1538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1579"/>
            <end position="1593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1644"/>
            <end position="1680"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDM38053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="1763" mass="192850" checksum="6312116E26172DD7" modified="2014-04-16" version="1">MPSPATSQRPSNRGGTAKSAKPLDIGEPLGVHDTNTVRSRVRKWQQQGGGVVTVDDPYADDGENDAKPKPKPAKVKIEKLEKLEKLAKVEKPNKPPTTRKRSHSTPRKRVVSDEHWKRTRSRASTQSSSRNLRNLPAPKRIAEYTTNEGQLRSPRGKHDDSDDEKKGRGPSKPLIRDTKSAGARQSIDTITESDYETDHPRSVEPSELSDRFKTRSPPPEDAWAASEADFSELSRRRKRGPAKPPKGGIFAHMLDESRKMFGIPEPEPPRPTPTPTTGRGAKIEAWLSDTPDPFLDEVVSKNDMPAPLDLKSGRARRSQKLADGDSQPPGTESEPSTISERRKSTDHPKSTEYSKSFDHHKSSDRPKSSDYPKSAINKHSKGRDSFSSIDKTHKAQDRETASESKRASIDRTSKSSVKSKGDNSVEDKLYEDSATTSESDLQPFSDGGSEVSGLNAPVPLGRKKPFPVTGHHRLSTIASAETLSTTITDITEHVPKSAPIEKLEIKLEPKLEPKPEPELESKLESTPESKHESKHESKLESKLAEEAEKAEEAEKDDQFDPDSLPVVSSQLKRRLTTHNDLMSVLSVSASRSRSIRSNRSIRTNKSRLAHATVEDLLYELSGDETKYMRELKTLVGGVIPVLLTCVLSRSDSAIAAGLFRPSLDPQDDVNFSKPIVNMGVAIERLKNLHKRIPQDNADALLTWAQGAQRVYREYLKAWRLGFKDVIVNLAPREEDEATNDADTKSLDEGLERDENGDFVDSDGEKVDVAYLLKRPLVRLKYLAKSFKGINILEPSPKAEETATAYQILVDDARKRVRDERARLEDDSAACIDPTRTRDPMTLGVLRGIGIDQTRHVRARDFFNLSLYHSSGQLVDCRAELLYRDNPASKGPGGDLLICEIDHSDRWLLFPPMDLRCVSARKGDSKHEIVLMLRSAPEDATKYWQELISLRIDEEEVGSEWVSLLGSDPIPPSICRSQSFISRAKQNKARKPSAVDSPPRSNDIDIPIGEKATGKRRSWTSKDHSSEPSTISSVIDARSSLSSIVTRETDYTTGGSELSKPARPDLPLLPSTAPRSSLTSQERTLAGLKRSKAKRFSRHSDSPASDTASQHTVSEKAPEHSAPAVAAPQTPSTPTGGRFYGETEESSAIGSPREKSRSRIPQPQKTPVREPSPESPRVSSVPSVNLPLIPKIRTPSSQPHLSTPTRMDPEDEEDYPPLEFLPRQEIMETPTRTRRRKSRRRPKDDDSPPPPPPHRSPSPAHGKRATHPVLTPTSGGLKRRGSSPLKHEYEPSTASDYSETDSDASTVRHYSYSSSEYSRSNGFSDSEDDYSSVSEDEEYATPKPRAHDSITDASSLSPSNSVSQGGYRTVPLQPTKTSKAIASVFAWSDKGNWELLFPDECTIVVSPGLIEAFAVDSEPDDSSSPRPLISLELTPLVPIRRGTAIDISIRSPPTERSQVTSSNNIMFRSCNPDECDALYGLINQSRINNPTYIALQNARGPFNSHASTFEPAPKAGGGLRRKSYRASSSPRSLAEGSESSVGTMSSAFSALKRFGNGSKMFNIARSTIESRTGREGSIYSGSGDSGNDPSPNSGLGRIAAAVKGADGIGLSNAKVRLYARESASKWSDMGAARLTIMPAPPKNPSRPGSGLSGDGSSPHGDNASGVSPPASGSASPRGALSTEKRIVIRGKTHGETLLDVCLGESAFERIARTGIAVSIREEDEDASIAKQGGVATGSGKIFMIQMKSEAEAAYTFGLVGKLRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W6QMJ4</accession>
    <name>W6QMJ4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="5">37S ribosomal protein S19, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">RSM19</name>
        <name evidence="5" type="ORF">PROQFM164_S02g000937</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS19 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QMJ4"/>
    <dbReference type="STRING" id="1365484.W6QMJ4"/>
    <dbReference type="OMA" id="EYVAFEV"/>
    <dbReference type="OrthoDB" id="2043at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.860.10">
        <property type="entry name" value="30s Ribosomal Protein S19, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00531">
        <property type="entry name" value="Ribosomal_uS19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002222">
        <property type="entry name" value="Ribosomal_uS19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020934">
        <property type="entry name" value="Ribosomal_uS19_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023575">
        <property type="entry name" value="Ribosomal_uS19_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11880">
        <property type="entry name" value="RIBOSOMAL PROTEIN S19P FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11880:SF8">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US19M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00203">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002144">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00975">
        <property type="entry name" value="RIBOSOMALS19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54570">
        <property type="entry name" value="Ribosomal protein S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00323">
        <property type="entry name" value="RIBOSOMAL_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDM30787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="94" mass="10690" checksum="C80F840BF4069F79" modified="2014-04-16" version="1">MFPTRALFGRSVWKGPNIVPLPLPRTLPPPPNTPPIRTTKRAATILPNFVGLRFAVHNGKTYVEIQVTEEMVGRKLGEYVATRKRFTYKQSKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W6QMP1</accession>
    <name>W6QMP1_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Peptide transporter PTR2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">PTR2</name>
        <name evidence="9" type="ORF">PROQFM164_S09g000064</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792023">
        <property type="protein sequence ID" value="CDM38148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QMP1"/>
    <dbReference type="OMA" id="WMHGAEG"/>
    <dbReference type="OrthoDB" id="8904098at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071916">
        <property type="term" value="F:dipeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17350">
        <property type="entry name" value="MFS_PTR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000085">
        <property type="entry name" value="MFS peptide transporter Ptr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000109">
        <property type="entry name" value="POT_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11654">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00854">
        <property type="entry name" value="PTR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="145"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="174"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="230"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="257"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="338"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="385"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="414"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="470"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="503"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="530"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="564"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM38148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="584" mass="64569" checksum="01F5A8E79C60854F" modified="2014-04-16" version="1">MSSTDREMETSAAPPYDTEEVTHHVVLNEKAMDAEFDKENQTTPDGGEPTLSEKISLRHVAENLPLSAWLVAVVELCERFTYYGMSGLFQNYVQRPRDGSEGRGALGMAHQGATGLTTFFQFWCYVTPIVGAIIADQYLGKYKTIVLFCFVYMIGLLILVCTSIPTALDHGSGIGGFIVAILIIGLGTGGIKSNVAPLIADQYKRKKMAITTTKKGERVVIDPALTIQRIYMIFYGCINLGSLSLLATPYMELYIDFWPAYLLCLCMFMVGTLVIILGRKFYVVRPPQGSIITDAFRAVWMMMKNRNMDAPKPSWQTEHNGASSVHWDDHFIDELKRALVACRVFAFYPIYWVVYGQFSGNFVTQAGQMDGHGIPNDLMQNFDPISIIVFIPILETCVYPLMRRLKIPFRPITRIALGFVVASLAMMYAAIVQHLIYDAGPCYGKPLCAASEVNGEAQGNRVHIAIQTPAYVFIGLSEIFASVSGLEYAYTKAPPSMKSFVQSMYLLTNAFGSALAEALTPAAYDPAVMWMFTGLACASCICGIIFFAVFHHLNAQEDDMNALDAEEEMPEAPVEAARGQSKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W6QMV2</accession>
    <name>W6QMV2_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">polynucleotide adenylyltransferase</fullName>
            <ecNumber evidence="2">2.7.7.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PROQFM164_S02g001092</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA polymerase type-B-like family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.19" evidence="2"/>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QMV2"/>
    <dbReference type="STRING" id="1365484.W6QMV2"/>
    <dbReference type="OMA" id="IPEHHLG"/>
    <dbReference type="OrthoDB" id="273917at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031499">
        <property type="term" value="C:TRAMP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990817">
        <property type="term" value="F:poly(A) RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010605">
        <property type="term" value="P:negative regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043634">
        <property type="term" value="P:polyadenylation-dependent ncRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05402">
        <property type="entry name" value="NT_PAP_TUTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.460.10:FF:000031">
        <property type="entry name" value="Topoisomerase family protein Trf4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054708">
        <property type="entry name" value="MTPAP-like_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002058">
        <property type="entry name" value="PAP_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045862">
        <property type="entry name" value="Trf4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23092:SF15">
        <property type="entry name" value="INACTIVE NON-CANONICAL POLY(A) RNA POLYMERASE PROTEIN TRF4-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23092">
        <property type="entry name" value="POLY(A) RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22600">
        <property type="entry name" value="MTPAP-like_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03828">
        <property type="entry name" value="PAP_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Poly(A) RNA polymerase mitochondrial-like central palm" evidence="7">
        <location>
            <begin position="254"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="PAP-associated" evidence="6">
        <location>
            <begin position="450"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="170"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="574"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="72"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="578"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="602"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="614"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="649"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="700"/>
            <end position="711"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF22600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM30942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="711" mass="79344" checksum="7011FE34DB53A394" modified="2014-04-16" version="1">MPMPSVAPFQFKGNSNYRGSRPNPRHEFTFRYQKPATSDRPLLSSKRESTPERLEGETKPELKFAELSTLSDSEEAEMDMSDDDAERPRKRRALGVDGSPETAPAPAAPKWSNPDPYTVLPPPAETTNKRVDVVKLIRKARLEVVAKTDETDAVKQNSDFISLGMDFEPEVSQSNAPENAPRGPKAQEGLDPAITSRKRTRDDELKGFSRKTGKPASRFNYDGSVIDQWKPLSQETGTPWFEGTPASLHVGTQLHNEILSFYHWAKPQEFEHIVRADLVNRLETAFQQRYHNVSIRAFGSFASGLYLPTADIDLVLLSHTFLRTGVRTFGERKGQIYAFSAFLKSTNLAVPNSIECIASARVPILKYVDKLTGLRVDLSFDNDSGLIANETFQKWKTQYPMMPVLLAVIKQFLLIRGLNEVPTGGIGGFAITCLVTNILQHLPQGHMQPNLGTILLDFLNFYGKQFSYTTIAVRMDPPGYFTKQYFGHPDRLTIEDPNNRDNDISGGTKEIGLILRAFSNAHTALKNRMEYLALVQGSNKSILEPIIAANFDEYVEQRFQLRQVFMAEDRFARYRKSSPPPPPPGSPPANGASPPPPPPIDGAPSSLPAPQARKPAKRLKAKLKGTKSEPEDISSDDAPGPEAKSAKARKGETRRQLCQERAARLKRLRPDLKKLPNTLSLRQARRHAGYETDEQMNADLDSREQKLLASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W6QN02</accession>
    <name>W6QN02_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S06g000282</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792020">
        <property type="protein sequence ID" value="CDM37321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QN02"/>
    <dbReference type="OrthoDB" id="5343483at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM37321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="205" mass="23635" checksum="2A78F6CD997E9CB7" modified="2014-04-16" version="1">MFHNSQESIEDPSRSLLGYVHYTFVNGSRNRQYRPAPGGRSNEIGWRIHLKRKARTTPKEWTDDPYFVCHLLALAQLKDRNRTVNPSKPITYTSRLLATHIHEKHFIILYEAQITSEVLNALSHWRDATTPIQWPTIKRKRIPYQPYDTFASRLIAEIRESRPSDSLSNISDGVDSVDEHGGERPYEPEDSGSSKMMRTSKEAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W6QNA4</accession>
    <name>W6QNA4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="8">(R,R)-butanediol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">bdhA</name>
        <name evidence="8" type="ORF">PROQFM164_S02g001277</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QNA4"/>
    <dbReference type="STRING" id="1365484.W6QNA4"/>
    <dbReference type="OMA" id="LFCGHCA"/>
    <dbReference type="OrthoDB" id="3941538at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000721">
        <property type="term" value="F:(R,R)-butanediol dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034079">
        <property type="term" value="P:butanediol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08233">
        <property type="entry name" value="butanediol_DH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161:SF23">
        <property type="entry name" value="(R,R)-BUTANEDIOL DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="7">
        <location>
            <begin position="8"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM31127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="359" mass="37764" checksum="190518821FF412B3" modified="2014-04-16" version="1">MRAVRFHGRGDIRVDEIEEPVCGDGQVKIRPAFVGICGSDIHEYLAGPTIVPATPHPLTDQKLPTTLGHEFSGTIEEVGSGVTGLKVGDRVAVKPNLYDSTCSNCTVGRFNCCEKVGFIGFSSGLSDHAVVDSRHAILLPDSIPLDVGALTGCGGDTALVEPLAVAWHAVSRSPLQLGDTVLVVGAGPISLAIIQVLKAKGITSIIAAEVSPRRREFALALGASEVFNPIEVDVIAQVLALTDNVGAAISFECSGVQAGLNTAIAGLRARGTTIVVSLWEKKPTIDASAFVFQEKHVTGAALYDDGDFEAVIAQIASGGIQPHSMITSKIRMEDIDEKGFKALIEEKDKHVKILVDISA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W6QNN2</accession>
    <name>W6QNN2_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S04</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S04g000595</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QNN2"/>
    <dbReference type="OrthoDB" id="5425892at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="28"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM35714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="102" mass="11400" checksum="70831D62A4964559" modified="2014-04-16" version="1">MASNNHNDNHGKVPASKEQIIILPFAQSHSPSNTTGSPGPTTEELCEKCWKPALARQHSWSNEDRKHQLQKRLQGPQKGRETGFTEAHSGDQNSPKQHLVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W6QNW9</accession>
    <name>W6QNW9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S04g000655</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QNW9"/>
    <dbReference type="OMA" id="YHCSIQG"/>
    <dbReference type="OrthoDB" id="4342350at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="235"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="372"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="426"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="297"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="324"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM35774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="566" mass="63743" checksum="43A587CD59135708" modified="2014-04-16" version="1">MSNRGNKLLYWPETNNMDSSQYFISWGSRRDIPIRRFEDLQSYRRDFIRSYEEVFQTAQTFTQHFSKQPLQSYDLERSLTINMGCDPSSWNKDADSPSIGWLDIVRHGDFQKQNDGTYHCSIQGKVLKFDQQVHDRVEFCRSHALQISSPRPSSADSLMEAEITLGILNNVTAEEKDESKYRKSLKKLKQKLMIRLSELQPFGDPITTYPTPTSDQAQYLTPHEPEAAFFPERLRASSSAQSCPLNGSSGSEMASEDHGDMSFDSSSEDSSEDETGDEMSEYKVLENKGPEEENGTGDDSSSQQTKNDSNNGGKAALAGDMAVPLNSLPSRTSSSMSRTGEDEAIMSTSHVSLPEGVEKAVSVSPMHLKDLSSISGNAVPMDPRSSQKAPELDMRISHPRCPPREGCNTLFENENLRPRAYKRRQSINISEARRRPRRTDHKSDHQERSVAAAWMKAHLHENWNQSRFVREYRANFGRSRTYITLKRWMDEEEGSQAKNRIVVLKVPVACLRETLSNDNSSSPAPGLSNGKLCVPSTFQNGAPEKPKSRWDVAPIKIESGLPNLLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W6QP08</accession>
    <name>W6QP08_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transketolase, bacterial-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PROQFM164_S04g000695</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the transketolase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QP08"/>
    <dbReference type="STRING" id="1365484.W6QP08"/>
    <dbReference type="OMA" id="DMADNTC"/>
    <dbReference type="OrthoDB" id="10267175at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006091">
        <property type="term" value="P:generation of precursor metabolites and energy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051157">
        <property type="entry name" value="PDH/Transketolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005474">
        <property type="entry name" value="Transketolase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43825">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE E1 COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43825:SF1">
        <property type="entry name" value="TRANSKETOLASE-LIKE PYRIMIDINE-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00456">
        <property type="entry name" value="Transketolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="TK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transketolase-like pyrimidine-binding" evidence="6">
        <location>
            <begin position="317"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM35814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="640" mass="69193" checksum="D9BF9F2FAB003F66" modified="2014-04-16" version="1">MSGNKFPVDLKLFKQLKLDPKTAQLSAQQKSDLLHNINIFRDAIIAFTATGAARGVSGHTGGPFDTAPEVCILLAFINANPSKWVDALYDEAGHRVATQYLLAALDGKIEPDHLLEYRAAGSHLPGHPELGLTPGIKFSSGRLGHMWGMVNGIAMANQDKNVILLGSDGSQQEGNDDEAARIAVAKNLNVKLFIDNNDVTIAGHPSDYLKGFDVAGNLKGHGLKVLSAQGENIDALYGAMCEVINHDGPAAVVVNRKMAPGIEEIEGQCKAHDVIPVDIARKYLTGRGYSQEQLAFYDNIKPGSNPHTYKGSTKDKGSNRNIFGEAVNDILDKLSKEEAKRRVMVIDSDLAGSTGLKAISAKHPESFIASGVMERGNFSAAAGFGFRSNGERQGVFSTFSAFLEMCISEITMARLNDCTVLSHFSHSGVDEMADNTCHFGLNHFFADNGLMDAETTTLYFPADGEQMKAVVNEVFWNKGLRFIFSTRSKVPYILKEGTDQKLFGEGYKFVPGKEEVIRKGSAGYIVSYGDMLYRSLDAVENLRAEGLDVGLINKPTLNIVDEETIKLYGSSPFVLVVESIAQKTGLGSRLGTQLLERNLTPKFKSLGANKEGCGGLYQQVNAQGLGPEHIIAAVKQVAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W6QPA9</accession>
    <name>W6QPA9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transcription factor, MADS-box</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PROQFM164_S02g001577</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QPA9"/>
    <dbReference type="STRING" id="1365484.W6QPA9"/>
    <dbReference type="OMA" id="ICHADIF"/>
    <dbReference type="OrthoDB" id="1898716at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1810.10">
        <property type="entry name" value="Transcription factor, MADS-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002100">
        <property type="entry name" value="TF_MADSbox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036879">
        <property type="entry name" value="TF_MADSbox_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00319">
        <property type="entry name" value="SRF-TF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55455">
        <property type="entry name" value="SRF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="MADS-box" evidence="7">
        <location>
            <begin position="24"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM31427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="102" mass="11462" checksum="F21E3847635CF671" modified="2014-04-16" version="1">MAAIKATKSKDTTSKRKLMRQKQCRRKTSLMKKACEYSRMCSADVCVGIRIRETGQVHILSADTSGFWAFLSSQLSSYYPAPMLVTDQDVQQVGKDTPQQPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W6QRM1</accession>
    <name>W6QRM1_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Spherulation-specific family 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S02g002343</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QRM1"/>
    <dbReference type="STRING" id="1365484.W6QRM1"/>
    <dbReference type="OMA" id="AWAPLEN"/>
    <dbReference type="OrthoDB" id="5342184at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021986">
        <property type="entry name" value="Spherulin4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35040:SF7">
        <property type="entry name" value="FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12138">
        <property type="entry name" value="Spherulin4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM32192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="299" mass="33057" checksum="4811EA4ACB38C406" modified="2014-04-16" version="1">MSTEKHVSNRTCLKSKLSRFILAIVVLIVIIVAVVPSVVVTTLHKKNSMGPKAKVFVPLYVYPAPEAWAPLENVISAHPDVNFTVVINPGNGPGPDSLPDGNYTREIPKLTAYDNVRVLGYVYTSYGKRNASEVRKDIQTYADWPTNSSDPNLAVRGIFFDETPQQYEAQTLTYLQGLTDFVKGLKALGPDQFVVHNPGAVPDSRYLATADSTVVFEAAYSTFRERQGAKLFSSISDSNRTQLCAIVHSVPESVEGKDLRSLVKQVRKVADEIYITHLSTNYYASFGSKWTEFVDLMAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W6QRT3</accession>
    <name>W6QRT3_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S05g000597</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QRT3"/>
    <dbReference type="OrthoDB" id="10609952at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM36764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="116" mass="12607" checksum="5710BE01506409D2" modified="2014-04-16" version="1">MAPVPQSIEPFLAWAFAGFITPVEASQSAWMWRSGLGGFAGHDIDSNPGRDGRLPSISAGPLHYSRDRPGQEFPPEAQTYINEDGRRGKGKKGPRLPESPGPNDTHRPSRLLPFSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W6QSN6</accession>
    <name>W6QSN6_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Casein kinase II subunit alpha</fullName>
            <shortName evidence="10">CK II alpha</shortName>
            <ecNumber evidence="10">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">cka</name>
        <name evidence="12" type="ORF">PROQFM164_S02g002653</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">Heterotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CK2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="10"/>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QSN6"/>
    <dbReference type="STRING" id="1365484.W6QSN6"/>
    <dbReference type="OMA" id="ECHMIEW"/>
    <dbReference type="OrthoDB" id="10254671at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005956">
        <property type="term" value="C:protein kinase CK2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006356">
        <property type="term" value="P:regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006359">
        <property type="term" value="P:regulation of transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14132">
        <property type="entry name" value="STKc_CK2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000059">
        <property type="entry name" value="Casein kinase II subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000088">
        <property type="entry name" value="Casein kinase II subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045216">
        <property type="entry name" value="CK2_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24054">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24054:SF0">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 10 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 9" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="32"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU369118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDM32502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="335" mass="39262" checksum="3FDC3DDDD9271DFA" modified="2014-04-16" version="1">MARVYADVNEHMPRSYWDYDSVNISWGVLENYEIVRKIGRGKYSEVFEGINVVNYQKCVIKVLKPVKKKKIKREIKILQNLAGGPNVVALLDVVRDNQSKTPSLVFEAINNTDFRTLYPRFSDYDVRFYVFELLKALDFCHSKGIMHRDVKPHNVMIDHEKRKLRLIDWGLAEFYHKGTEYNVRVASRYFKGPELLVDFQEYDYSLDMWSLGAMFASMIFRKEPFFHGGSNTDQLVKIAKVLGTEELFEYLDKYDIELDPQYDDILSRFPRKPWHSFVNAENQRFISDEAIDFLDKLLRYDHADRLTAQEAMAHAYFDPVRADAAALSHNNVTLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W6QTB8</accession>
    <name>W6QTB8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S02g002903</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QTB8"/>
    <dbReference type="OMA" id="GCTEHSE"/>
    <dbReference type="OrthoDB" id="4288742at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004881886" evidence="2">
        <location>
            <begin position="17"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM32752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="115" mass="13039" checksum="A71C3A000D2291FD" modified="2014-04-16" version="1">MTFSIFLLLPSVYIRAAFCGIYTVIDYDRQCMIWPDSNYGCTEHSEPFALLDGDDCSDLSKVTYGIRKDHSKVDMGVFGTVCWQLVYYSRSAIIVFISIVCFRLVFVGAVSILHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>W6QUS1</accession>
    <name>W6QUS1_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial thiamine pyrophosphate carrier 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PROQFM164_S02g003419</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mitochondrial transporter that mediates uptake of thiamine pyrophosphate (ThPP) into mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM33267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QUS1"/>
    <dbReference type="STRING" id="1365484.W6QUS1"/>
    <dbReference type="OMA" id="MYVCYGA"/>
    <dbReference type="OrthoDB" id="18574at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090422">
        <property type="term" value="F:thiamine pyrophosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000011">
        <property type="entry name" value="Mitochondrial thiamine pyrophosphate carrier 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24089">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 13" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="12"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="120"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="213"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDM33267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="318" mass="34350" checksum="9A24B22BCC95806E" modified="2014-04-16" version="1">MSAGGEHLKDEGTKRQVVLAGGIAGLISRFCIAPLDVVKIRLQLQIHSLSDPASHNSVNGPVYKGTLSTMRTIMKQEGITGLWKGNIPAEMMYVCYGAMQFTAYRGTTQALAQLGSYRLPQPVESFISGAVGGGCATGMTYPLDLLRTRFAAQGPDRVYSSLRASIVEIARQEGAPGFFRGCSAAVAQIVPYMGLFFTTYEAVRPVMTWEDLPFGTGDAAAGVVASVLAKTGVFPLDLVRKRLQVQGPTRTRYVHRNIPEYNGVLRSIAMIVRTQGVRGLYRGLTVSLLKAAPASAVTMWTYEHTLKVLQELNVAADS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W6QVQ3</accession>
    <name>W6QVQ3_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S03g000371</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QVQ3"/>
    <dbReference type="STRING" id="1365484.W6QVQ3"/>
    <dbReference type="OMA" id="FPQWAGQ"/>
    <dbReference type="OrthoDB" id="444127at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050317">
        <property type="entry name" value="Plant_Fungal_Acyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31642:SF310">
        <property type="entry name" value="FATTY ALCOHOL:CAFFEOYL-COA ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31642">
        <property type="entry name" value="TRICHOTHECENE 3-O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02458">
        <property type="entry name" value="Transferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM33647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="517" mass="57015" checksum="118C9C21597FC1B4" modified="2014-04-16" version="1">MTTIESTRLRPASQLTPTSTPLSILDATVVRFAPTGAIWIFNQSADLDQKTLVDRLRTSFIETLSKFPQWAGQLQWAPVNPKGDHTERFNRPLIVYGTDTDPGVEWTVIERPFRADEIVPTAGERASSTTGSQPGVWVGDDFDERLFISSNPLALANLRDYAGLPGMQVQITLLQEGGYVIGIKMAHCLADAQTLMVFVHLWAHNSKKQFGNQPESPLMGEPVFDPTLLDNCAAGDIDSPEPDQTLVHTARKLPLHRYSWWDTSDEGYPAFLIPTTENSKPAEIDYKQVSPSEPAPWGSWDFSKEVRYTQLHFTGAELSKFQAAALDTGSRGDISRLDALLAHLWIAITRARGQANSSRPIYMDLSLGTRPRVSPALPDTFIGSPLFLTHVGGTASSICQEILGETASRIRETMKRFTADAVGAMLHDAAHEVSPQRLWQGFLGPEHTLVTSWLRLQVYEVDFVGGDKPRYVHAVMPKMDGCLQVMDSGVHDGGVDVALYLDAVATGRLLDGDCFRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W6QW53</accession>
    <name>W6QW53_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S11g000057</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792025">
        <property type="protein sequence ID" value="CDM38354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QW53"/>
    <dbReference type="OrthoDB" id="4366282at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM38354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="167" mass="18413" checksum="9C1AAF35FB708B68" modified="2014-04-16" version="1">MSDSNVCGKCGARRRGESKDFQFFVAKSVIGFITMTACFVLMRLFFLGALTQPMSNQSDISLPAMGNHSDQLSGVDFTLYAVDASMNEQDAIQSYYSAFVNETPPVRKELEINSASRLDEKPRSAYITQDSSNLCVSWATYATSKMTSAEETEISTFSTECGSKGYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>W6QWI4</accession>
    <name>W6QWI4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="10">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PROQFM164_S03g000601</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QWI4"/>
    <dbReference type="STRING" id="1365484.W6QWI4"/>
    <dbReference type="OMA" id="PYIASAC"/>
    <dbReference type="OrthoDB" id="5290825at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015798">
        <property type="term" value="P:myo-inositol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015791">
        <property type="term" value="P:polyol transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000100">
        <property type="entry name" value="MFS sugar transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050814">
        <property type="entry name" value="Myo-inositol_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020">
        <property type="entry name" value="PROTON MYO-INOSITOL COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020:SF4">
        <property type="entry name" value="SYMPORT, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G11790)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="112"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="219"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="253"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="281"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="375"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="410"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="439"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="468"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="506"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="537"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="116"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDM33877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="633" mass="70860" checksum="582171EF328B9035" modified="2014-04-16" version="1">MVQEVITQVDSGQRSSNDQNSAEKGYIEQVDLQNNVTARIKNPLADLTKTQVLRNVEEFAEEYNVTNILPELKKGALVARDPAEFETVADLTELELTALRDEVAHKWRQPRSLYFTIVLCSIGAAVQGWDQTGSNGANLSFPDAFGISEDPQKSAHANRNLWLVGIVNAAPYIASACLGCWLSDPCNRILGRRGTIFIASIFCVLTPIGSAVTQNWIQLFVVRLLLGIGMGLKASTIPIFCAENTPAVIRGGLVMSWQLWTAFGIFLGFSANLAVKDTGKISWRLQLGSAFIPAIPLLFGVYFCPESPRWYIRRGEMDKAYRSLCRLRNTPLQAARDLYYIHTQIKIEMDLIGNSNYVTRFVELFTIPRVRRATLASFVVMIAQQMCGINIVAFYSSTVFKNAGANDTQALFASWGFGLVNFVFAFPAIWTIDTYGRRTLLLFTFPQMAWTLLGAAFCFWTPEGTGHLASIAFFVFLFAAFYSPGEGPVPFTYSAEVFPLSHREVGMSWAVATCLGWAAVLSITFPKMLSAMTATGAFAFYAGLNVTAMVMIFLWVPETKQRTLEELDYIFAVPTRVHMKYQVTKALPYWFRRYIFRQNVELEPLYKFDHLASANEDVILSRRQSVFSDHGKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W6R1Y4</accession>
    <name>W6R1Y4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein mmf1, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">mmf1</name>
        <name evidence="2" type="ORF">PROQFM164_S04g000713</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RutC family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6R1Y4"/>
    <dbReference type="STRING" id="1365484.W6R1Y4"/>
    <dbReference type="OMA" id="VKLNIFM"/>
    <dbReference type="OrthoDB" id="309640at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019239">
        <property type="term" value="F:deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00448">
        <property type="entry name" value="YjgF_YER057c_UK114_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.40:FF:000001">
        <property type="entry name" value="L-PSP family endoribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="entry name" value="RutC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006056">
        <property type="entry name" value="RidA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00004">
        <property type="entry name" value="Rid family detoxifying hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
        <property type="entry name" value="2-IMINOBUTANOATE/2-IMINOPROPANOATE DEAMINASE RIDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803:SF22">
        <property type="entry name" value="ENDORIBONUCLEASE FAMILY PROTEIN BRT1, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G03780)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="YjgF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM35832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="128" mass="13843" checksum="E80DA0F0B270A5BA" modified="2014-04-16" version="1">MSSKTAVLTDKAPKPLPGIYSQAIVANGVVYCSGAVPMDAVTGKLIDGDIKAHTHQCIKNLTHILEEAGTDITKVVKVNVFLSNMDDFAEMNSVYMQYWGDVKPCRTCVAVKTLPLNTDVEIECIAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W6R211</accession>
    <name>W6R211_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transaldolase</fullName>
            <ecNumber evidence="2">2.2.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S04g000748</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the rate-limiting step of the non-oxidative phase in the pentose phosphate pathway. Catalyzes the reversible conversion of sedheptulose-7-phosphate and D-glyceraldehyde 3-phosphate into erythrose-4-phosphate and beta-D-fructose 6-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>D-sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-erythrose 4-phosphate + beta-D-fructose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:17053"/>
            <dbReference type="ChEBI" id="CHEBI:16897"/>
            <dbReference type="ChEBI" id="CHEBI:57483"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="2.2.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate degradation; pentose phosphate pathway; D-glyceraldehyde 3-phosphate and beta-D-fructose 6-phosphate from D-ribose 5-phosphate and D-xylulose 5-phosphate (non-oxidative stage): step 2/3.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.2" evidence="2"/>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6R211"/>
    <dbReference type="STRING" id="1365484.W6R211"/>
    <dbReference type="OMA" id="IFCDMQD"/>
    <dbReference type="OrthoDB" id="1711136at2759"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00414"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004801">
        <property type="term" value="F:transaldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009052">
        <property type="term" value="P:pentose-phosphate shunt, non-oxidative branch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001585">
        <property type="entry name" value="TAL/FSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018225">
        <property type="entry name" value="Transaldolase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10683">
        <property type="entry name" value="TRANSALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10683:SF34">
        <property type="entry name" value="TRANSALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00923">
        <property type="entry name" value="TAL_FSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00958">
        <property type="entry name" value="TRANSALDOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0570">Pentose shunt</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0704">Schiff base</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM35867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="324" mass="35292" checksum="92ED45177E080588" modified="2014-04-16" version="1">MAVQTGLDYMRSRTQIDCDTLDDEVAKTLGPFEDCTSNQAIALGELSKPARAEVIAAAQADAKKLHPNYSSTTVEELAVEIATVRLAVGMAKHIRGRVHVQVNPYYSYSSEKIAANAFRILQLFHYVQPGFDVSRISIKIPSTWEGMMACHTLEAAGVHTLATTLFSMAQAVLAAEVGCTYIAPYVNELRVHVQAGFVDNAKLLPLCAAIQKYYKSINSPTKVLPASLTSVEEIFCLAGVDHLTISPGLLTQLTQPYVGDVKSLLDIEPTLPIPAQEYSLISDPGNYQIRFARDLGGASQIKLTEAINIFCDAQDKLELLMKGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W6R3C0</accession>
    <name>W6R3C0_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein kinase-like domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S05g000120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6R3C0"/>
    <dbReference type="STRING" id="1365484.W6R3C0"/>
    <dbReference type="OMA" id="FFPVWWE"/>
    <dbReference type="OrthoDB" id="8300194at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05120">
        <property type="entry name" value="APH_ChoK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF48">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="53"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM36287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="293" mass="33207" checksum="BB958955878D8F70" modified="2014-04-16" version="1">MATENTCSACSWSPTRQDACRYQSHVNLFYGVSNRGVWSLGSNLILKERSSDPPNFEAPNVRFLASRTSIPIPQIVEEWQEDDGASFLLTKRIRGQTLSEIWPKMTSADKERVAKQTAEYLMQLHELRSDRLESIGGHPIYSAFLFPNGYGIGHGPFSSDDELWAEMSLALTQVPEQVRSKLRQRMPAATPYTFTHGDLTNVNIIVENGNLAGILDWESSAFFPVWWEFTCAGIGLGQDDKEWKDLLCTHLPDHTEARNFWLDFFALRNYPKLNERGLALLKECGSSLPEKET</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W6R475</accession>
    <name>W6R475_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">S-crystallin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S05g000440</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6R475"/>
    <dbReference type="STRING" id="1365484.W6R475"/>
    <dbReference type="OMA" id="LECNIAH"/>
    <dbReference type="OrthoDB" id="202840at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00299">
        <property type="entry name" value="GST_C_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00570">
        <property type="entry name" value="GST_N_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050983">
        <property type="entry name" value="GST_Omega/HSP26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43968">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43968:SF8">
        <property type="entry name" value="S-TRANSFERASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G00590)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="1">
        <location>
            <begin position="5"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="2">
        <location>
            <begin position="90"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM36607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="247" mass="27839" checksum="37809A35426E2BCF" modified="2014-04-16" version="1">MATRESIKLFTNRNCPWAHRVHIVLAELGLPFEEEIIDYSKPRQPEYLKINPRGQVPTLTYGDHIIFESAFIAQFLADSVTSTHLTPRTGEAQGALIRHRIAFFVETYFSKANIYYYRAIEAKTDEDADELGKRYVDAVVKEVEPLLQDAKPFFGGSDKLTMAEVLTASFILRISTLPHTENAPLPNTMVAGMEEKAPKFFAWAQAAMKHPSVNGIYNKDGCAAEMRDRRAKARGLNQLLILHSVPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W6R4P2</accession>
    <name>W6R4P2_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S05g000605</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6R4P2"/>
    <dbReference type="STRING" id="1365484.W6R4P2"/>
    <dbReference type="OMA" id="EHEDMWF"/>
    <dbReference type="OrthoDB" id="3029470at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM36772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="473" mass="53669" checksum="36C31FC5179A8EA7" modified="2014-04-16" version="1">MNTTPQQILNIEDALVSEANPARLNGPLDYERCARLHNYLVAYGWMARHGQETPNLDVLASQPFIFADEDTQAVRERLHPSVNSFLDSIFSPEPGFFYWINDISMQLVDNIFLGEDNDLDDLERFVIIYGTVLELGSHCVGVVYDQQLHRAAFPMTLENLDSVEPIGEHEDMWFPLETILTHWIYMLRIGKITTDSPEGEAPKELANSRSQIGLWSWLPYCPSQVDSTVAAIDRYSAAIEARMPSGSLLPVSRDAPLFTDVELDAASIPEECFIRSVLTRMRTPRFRAIAPGLEVPHDTMAFTARQRFTGVPREQEEWGNNIPPVLIFAAADSSHTVGFGEEIRWLFFAPGDEIPFDENDLIPTGLYSESVRRCQYDCEEAGFRLLLPFWDHDGARMSDGTSISPGSVTQLFQHGIFHPFGGERRAQRLERLIDRWRELVESGVWTVGRDGVEGTIDQFHIDSAKNYWIAPDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W6R5F9</accession>
    <name>W6R5F9_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S06g000012</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792020">
        <property type="protein sequence ID" value="CDM37052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6R5F9"/>
    <dbReference type="STRING" id="1365484.W6R5F9"/>
    <dbReference type="OrthoDB" id="4194035at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase" evidence="1">
        <location>
            <begin position="69"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM37052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="180" mass="20124" checksum="97C60A7767381D23" modified="2014-04-16" version="1">MTIPSLGRVASLFPHIEKDWWKKAYNEMYLYTDGDCVEVPAITEAECNDIIGISSVQQLLKTQESSIKVLDLCCGQGRHSINLAKRFPSVNFYGIDQSTYLLDLARKRAIEENVQSNVTFQKGDLRRIPASDCSFDLVILLGNSFGHCNDEGDLQSLREASRVLKPGGIFVIDHVDGAWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W6R5X2</accession>
    <name>W6R5X2_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S06g000173</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792020">
        <property type="protein sequence ID" value="CDM37212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6R5X2"/>
    <dbReference type="STRING" id="1365484.W6R5X2"/>
    <dbReference type="OMA" id="HTLYGIY"/>
    <dbReference type="OrthoDB" id="5404940at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="148"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="199"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="320"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="398"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="513"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="691"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="330"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="413"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="526"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="559"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="610"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="691"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="720"/>
            <end position="730"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM37212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="741" mass="81766" checksum="C98B16CB0FA21F36" modified="2014-04-16" version="1">MGRSSPPFLYESPSFKGPTDRGFNPRDATGTIWTRPTDKPKQKESQVNLNRHPDTWGSFNTVSSFTPMSYKTKNRVKYARGSQLALRVLSLLGALGSLFCSIVIKGAAVTVIWIIRVGPIVAILHTIYGAYHNCRSALRRPTGSQASYGLFAAIVDLGIIPFYVFTAFIAYGEWTSNAYHWGTLFNNSDLTVKLSEATFILAIANGGLHLISLAISGFLAVTFRKISRLPPDMNPLEDNLTARPRISHKEARTDEKHLSQSTMNSSFEDPLIGSPRSVPFMHTREQSFGGDYNRESMGMLDEQRQSHPSFYQHRLSHLESPTEPYMDPSSPDTLFQQPASLPYDFTSQAPAPEYRKVASHAPEIIDATAQLRHLSSRTADRSDTASPLSDNWVAYSERSLSPTGERQDESAATLRQSSSVYSRKSNKTTTSVSSGIRDWFAYGPKPEPGAASAIPEDVRGEYASLTTHEFYGLDDNRREQDVGDQRMDIFPDPEYHRDDFDDEHDEYLPFNPLMLNPPTPQPILTDRPENTDPVRRVVLGDNPNISYNAQPVSLPHESPNLSHNTQAQTEPVPRDSPKPTSPKTRFYGELDVNGNPGLASRDPSEQVVRKPTKLTKKRSSKMSAYAALKKNDNDEENGYLSTASPRAIESDRKGRVVSNTGADTARPGIAAGVGASLSTYGSYIAGLGVGRRRDVSGKVAEEGRSESLLDEPPSHEQNETHPQVPSSSANRAAGWARFAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W6PQH5</accession>
    <name>W6PQH5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NLI interacting factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S01g000247</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PQH5"/>
    <dbReference type="STRING" id="1365484.W6PQH5"/>
    <dbReference type="OMA" id="SMVLDCT"/>
    <dbReference type="OrthoDB" id="277011at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904262">
        <property type="term" value="P:negative regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009651">
        <property type="term" value="P:response to salt stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07521">
        <property type="entry name" value="HAD_FCP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000043">
        <property type="entry name" value="General stress response phosphoprotein phosphatase Psr1/2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011948">
        <property type="entry name" value="Dullard_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050365">
        <property type="entry name" value="TIM50"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02251">
        <property type="entry name" value="HIF-SF_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12210">
        <property type="entry name" value="DULLARD PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FCP1 homology" evidence="2">
        <location>
            <begin position="376"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="345"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="23"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="269"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="345"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM26438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="550" mass="59557" checksum="D5F6FF8E555024E3" modified="2014-04-16" version="1">MSGEGTARDSALESADKALMNTSGLPGSSSPEPEQGRGTDATATQDATSVAPSDPASSPSESTPTAAEGVNAPKKRHLLIPIPSRRSSRTNKQQESEKTEEAAQDEPSRRSSKVSILRSKRDHSRASSRRSRQTQNGVNAEESKEATTMPGHNPSKPQQKKSPSKFLAFLGCCSSSDVDADDTALPAKKTTMRPPASNRLPTPDKVEPPTGDSSTVESREPYLDEKANSTVSADQPGEEDRNIHPAMASVQGDGPSVDATQPEFSGQKDQTKDVTPHDQTKIVMESVPEVKADANTYNGEGQSTSTTEDLPSASTSTIPKDFGTDGQEEATSHQEMKLPVVIPPPPPPLPPAPPAPPARGNYEDEAHPLLPAPLPHLSGRKCLVLDLDETLVHSSFKVLERADFTIPVEIEGQYHNIYVIKRPGVDAFMKRVGELYEVVVFTASVSKYGDPLLDQLDIHNVVHHRLFRESCYNHQGNYVKDLSQVGRDLKDTIIIDNSPTSYIFHPEHAIPISSWFSDAHDNELLDLIPVLEDLAGPLVQDVSMVLDCTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W6PQL1</accession>
    <name>W6PQL1_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S01g000287</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PQL1"/>
    <dbReference type="OMA" id="NARDYRC"/>
    <dbReference type="OrthoDB" id="4361257at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM26478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="111" mass="12804" checksum="C4B08858F41B50EF" modified="2014-04-16" version="1">MFYQNGRLIQELEYNPRGTNWVNIFFNARDYRCDDLAIMRTVVTCIRTRVVSITGHAMHHDIPLCISIQVPGEHGDKESILATAELLAEYLRGQVARGSVNINRSLLFRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>W6PSA1</accession>
    <name>W6PSA1_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein disulfide-isomerase</fullName>
            <ecNumber evidence="3">5.3.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PROQFM164_S01g000912</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Catalyzes the rearrangement of -S-S- bonds in proteins.</text>
            <dbReference type="EC" id="5.3.4.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="5.3.4.1" evidence="3"/>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PSA1"/>
    <dbReference type="STRING" id="1365484.W6PSA1"/>
    <dbReference type="OMA" id="NHVKRAT"/>
    <dbReference type="OrthoDB" id="10264505at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003756">
        <property type="term" value="F:protein disulfide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034976">
        <property type="term" value="P:response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03002">
        <property type="entry name" value="PDI_a_MPD1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057305">
        <property type="entry name" value="Thioredox_PDIA6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45815">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE A6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45815:SF3">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE A6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24541">
        <property type="entry name" value="Thioredox_PDIA6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004879172" description="protein disulfide-isomerase" evidence="8">
        <location>
            <begin position="22"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="9">
        <location>
            <begin position="13"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="243"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="448"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="248"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="286"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="459"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="473"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDM27103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="489" mass="52246" checksum="A4B50699F37266A4" modified="2014-04-16" version="1">MLHSASLLLVTSLLAALPVNADGLYTKNSPVIQLNPKTYNSLIANSNYTSIVEFYAPWCGHCKNLKPAFEKAAKNLDGLAKVAAINCDDDENKAFCGQMGVQGFPTLKIVTPSKKPGKPRVEDYQGARSAKGIVDAVVDRIPNHVKRATDKDLDKWLGQNEDRPKAILFTEKGTTGALIRALAVDFLGAIDIAQVRNKESASVKKFGVTEFPTLVLVPSADTEHKIYTGDLKKKPITEFLSQAATPNPDASPRSASDSKPKSKPKSKPASKPTSIVDDAEDLKPTASENQDTTDPSAKPIQVPIPAPPIPTLSTPESLDSACLASKSGTCVLVILPEASEPDAALPAPATEALASLAEIGHKHAQRGTHLFPLYAVPAINTRSKTLREALALADGQTVEIIALNARRGWWRRFSGADADFGAVAIESWVDAIRLGEGAKEKLPEGIVVSDEAEVKPEAEAEVEPDAETVEADAEPKPEADEQAVEHDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W6PSX9</accession>
    <name>W6PSX9_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF3824 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S01g000789</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PSX9"/>
    <dbReference type="STRING" id="1365484.W6PSX9"/>
    <dbReference type="OMA" id="DRFDSQG"/>
    <dbReference type="OrthoDB" id="3561737at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024436">
        <property type="entry name" value="DUF3824"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35487">
        <property type="entry name" value="DUF3824 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35487:SF1">
        <property type="entry name" value="DUF3824 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12868">
        <property type="entry name" value="DUF3824"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3824" evidence="2">
        <location>
            <begin position="493"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3824" evidence="2">
        <location>
            <begin position="713"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="289"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="384"/>
            <end position="813"/>
        </location>
    </feature>
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        <location>
            <begin position="49"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="101"/>
        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="116"/>
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        </location>
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    <feature type="compositionally biased region" description="Basic residues" evidence="1">
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            <begin position="246"/>
            <end position="269"/>
        </location>
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    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="301"/>
            <end position="313"/>
        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="315"/>
            <end position="330"/>
        </location>
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        </location>
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        </location>
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        </location>
    </feature>
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            <end position="477"/>
        </location>
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        </location>
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            <begin position="775"/>
            <end position="787"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM26980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="829" mass="94117" checksum="5E904EEFA0DD7C27" modified="2014-04-16" version="1">MSYTYRERERDWDETRPVSIKRYVISPEDDRRDFMSRHDDSFGGEREVVIRRKTDREEPVTVSRYEREVEYEPPTRYERDYDSRIYTSPRESEYDVVRRSEVDEDPYYYNRHRRVREYDEARSRRELSPDDSVSQSSRRHRGDRDQDYSSDDSMVYIRKETRDYDDHPHHRRHLAEGALVGVGAAELLRNHNKKDGEVSHGASRIGRTIGAGALGAVAVSAASHARDYYRSKSRHRSHSFEDDRSSHRHSRHGRSRHSRSRSRSQSHSRAKTLLELGVGAAAVAAGVAALRSKSKADERKSRSRTRSRSRVSSRGRSEKDGEQGKRSMSERRKHMAEAGLAGAAVAGLVEKVRSQSRSRKGERSRSRLRQALPIVAAGLATAAATGLYEKQKSDKDEKEGSSRGRHRSRSHSRAPSQSYPDPTRDSAGLIEYGNDPVAGSIPSEHYYGQPDAPYYDEQEAYGPRRHPRSRSRSRSRVRYSSSSSSDGEGHRRRHRSRSRDLAGAALGATGLGYAAHKYNERRKSRERDREHSTHDDNVHRDPYEESYNPEPYPLSPQAAPSAPPMPDPHYYPSNPNPNPNPNPNYYPPPPGDSTYNLNSTPASYNPADYPPPPGAAPPQPYAYGAAPPGPGPEQYTHRPRRAEDNVRPLPIDANHAHKGLNIHPFPTSAPRSISQPPKSVAFDLTDPPHDPGYETDDSDSTVGSGSSSHRGGRDHRHDRDRDRDRDRDRDSRHHHHRRSSSVPYPPMPPPSSTASDRHNFYPDSSHHRHHPSAPKHHEERDQNKAPEADSDSTIDLPSRFDGQGRPLPERDPAVDKFEDLVNRFTKVLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W6PUA0</accession>
    <name>W6PUA0_PENRF</name>
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        <submittedName>
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        </submittedName>
    </protein>
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    </gene>
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            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
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                <person name="Giraud T."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
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    <dbReference type="Proteomes" id="UP000030686">
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    </dbReference>
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        <location>
            <begin position="54"/>
            <end position="125"/>
        </location>
    </feature>
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        <location>
            <begin position="59"/>
            <end position="68"/>
        </location>
    </feature>
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            <end position="113"/>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM27465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="145" mass="15838" checksum="F539A0B33B82ED9F" modified="2014-04-16" version="1">MKVTWNEKADAKLLAGILANNPTPIDFNALAEYMGDGVTACAIRHRVTRLRAKAAEMNDGSSTSSPASPVTRKRQRRTPKKSAKVAPAKHKDADPESGGEGPVPEDEEIDGEDTNDKKCKIKHEETEETFFLDGIVKEDEDSSDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W6PUI7</accession>
    <name>W6PUI7_PENRF</name>
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        <submittedName>
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    </gene>
    <organism evidence="8 9">
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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        </lineage>
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    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
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                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
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        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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    </comment>
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    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <begin position="129"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="209"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="32"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM27550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="228" mass="25146" checksum="063F8D606FF2AAD7" modified="2014-04-16" version="1">MAESTGTVAYCGQQLIGVSIAIAAIQIIIVGARFYTRHIQRVANGIDDYLMIPALIASLAQSALYIYLVKRGGVGYHLEYVARTPSKLVILQKGLYANQILDFPFTIAPAKVSILLFYVRLFPVRMFRIFAYIVGAIVLGHGLGVLLAAIFQCSPIAYTWDRTIAGGSCFNQEAFYRYVSLPNIMTDVLILVMPLPYVWKLHTRIGQKVALTGVFLLGSLGTSRVFFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W6PUK5</accession>
    <name>W6PUK5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S01g001381</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
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            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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            <authorList>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PUK5"/>
    <dbReference type="OrthoDB" id="10452239at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM27570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="73" mass="8771" checksum="97C9D44237FBBC7F" modified="2014-04-16" version="1">MGHRYFDLDLKYIIYRLLPAFCRPIMITTGFNYSCDRIHRLFTHNQIVAECHKYCVRAILNSRIKALPQWDLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2024-10-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>W6PVQ0</accession>
    <name>W6PVQ0_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S01g001791</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PVQ0"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <source>
            <dbReference type="EMBL" id="CDM27980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="37" mass="3955" checksum="37F919AE77732259" modified="2014-04-16" version="1">MHISTPLYKNGPGPFTALASMHKSLDTVTTCRHVQGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2024-10-02" version="15" xmlns="https://uniprot.org/uniprot">
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    <name>W6PVQ8_PENRF</name>
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        <submittedName>
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        </submittedName>
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    </gene>
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        <lineage>
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            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
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                <person name="Silar P."/>
                <person name="Lacoste S."/>
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                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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        <source>
            <dbReference type="EMBL" id="CDM27856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="48" mass="5246" checksum="3F6FEC766AF8A90E" modified="2014-04-16" version="1">MACPPSQEPGSHWTIGIDPKQPVGTWTVTFNLTGTDSSYMNVPRGRKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W6PXU5</accession>
    <name>W6PXU5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Mitochondrial outer membrane translocase complex, subunit Tom22</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PROQFM164_S01g002566</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="14">FM164</strain>
        </source>
    </reference>
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        <property type="project" value="InterPro"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12504:SF0">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM22 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04281">
        <property type="entry name" value="Tom22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="10"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="27"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009874"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDM28755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="149" mass="16507" checksum="71024262914F2054" modified="2014-04-16" version="1">MVKLTEVEDEHFTDKPTATKHDALLVSDDEDDYSDTDSEISDEEDIELEAESLYERIAALKDIVPPSARRNVSSTVSSITNLTKATFSFSGKALWIISTSAFLLGVPFALAYAEEEQYIQMEREQGMIKGANEMLIPGSEPEKTAQPTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W6PXW7</accession>
    <name>W6PXW7_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PROQFM164_S01g002904</name>
    </gene>
    <organism evidence="7 8">
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
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        </lineage>
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    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792015">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1365484.W6PXW7"/>
    <dbReference type="OMA" id="IACEPLF"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF145">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
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            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="225"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
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            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="335"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="377"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="404"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="438"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="472"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="71"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CDM29093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="514" mass="56578" checksum="9A955DD37A94C649" modified="2014-04-16" version="1">MPNLYHPETLRNDSEQTDSVDVCTETYFASHLEPAISKLASIHAPPEFEVYWDSDDPENPHMWPLWYKGLTVAAMSLGATVVSLSSTLYTSGIPGLQDDFHVSKIVALLGVTTYLLGMGIGSIIFAPLSELVGRRPIYIVSMIIFLFLLLPSALAQSIASILVSRFFGGFFGSALMSNSPASVNDIVSDKHRALAFGFWSIGPTNGPVYGPIIGGFVFQYLGWRWTNWIVLIIGGVVLVLISSVKETYAPVILKKRAAIKRKETQDPKWWTRYDDGVGFTSSLMINLKRPFVMLLTEPICIFWDGYVAIVYGILYLCFVAYPIAFQQERGWSPGIGGLSFVGIGVGVLIAIACEPLFRKVINLHRKDPETGMVQPEAMVSVVFFGATLLAIGQLWFSWTCTPNVHWIIPILAGVPFGIGNACVFIYASNYIARSYGIYAASALAGNMLTRSVMGAFLPLAGPSMYKTLGLNWASTILGIVETVCILIPVVFYFYGHRIRKASRFIKEVEKLQAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W6PY22</accession>
    <name>W6PY22_PENRF</name>
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        <recommendedName>
            <fullName evidence="2">histidine kinase</fullName>
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    </protein>
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        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1365484.W6PY22"/>
    <dbReference type="OMA" id="WGQKATF"/>
    <dbReference type="OrthoDB" id="303614at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009927">
        <property type="term" value="F:histidine phosphotransfer kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16922">
        <property type="entry name" value="HATPase_EvgS-ArcB-TorS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000010">
        <property type="entry name" value="Sensor histidine kinase RcsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.130:FF:000024">
        <property type="entry name" value="Sensor histidine kinase/response regulator"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Sensor histidine kinase/response regulator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43047:SF74">
        <property type="entry name" value="HISTIDINE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43047">
        <property type="entry name" value="TWO-COMPONENT HISTIDINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PAC" evidence="10">
        <location>
            <begin position="944"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="10">
        <location>
            <begin position="1111"/>
            <end position="1165"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="1183"/>
            <end position="1409"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="9">
        <location>
            <begin position="1707"/>
            <end position="1829"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="57"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="117"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="217"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="336"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="535"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1403"/>
            <end position="1533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="82"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="117"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="145"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
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            <begin position="157"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
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            <begin position="224"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
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            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
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            <end position="1475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1486"/>
            <end position="1508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1515"/>
            <end position="1527"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="6">
        <location>
            <position position="1759"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDM28865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="1854" mass="205954" checksum="918F74341D0A9C13" modified="2014-04-16" version="1">MEDVYSRRSSPFPSPSETHPSAVSMQPLRSPGHRPPHGHQSQKLVDELADRVDALEKSSLNPSRLSRGDSTEQVVGLTPITEDARSEVERQEDQGRSSHTLKELRKQMEDLLVYQQMQQTQPVSSQNQPASAPSNDTPRKRRLSSALSNTSTEAPFTSSHTSAGSVSSAGTIRGVQIETPSDRKPAYTPSYPFPHIQTKPSKMGIESIGRGPFRLKLPSEKSHSSTPGYQTLPSEPKASEPHPTFLPAHHSQTQEDPNFASPDLYDLTLQLNADSGLELWWTNLINILQTHYGAERVSLAVPGDVTDLENVPWGQKAIFNQNVDTSLHELQARHIEKRPSTEAPHSRKSVSQQKPETVHQARMPGPSRPSLLSRHSFAGFDKGQGHTPHATSRPQLSKINVKPEKRHVHIASQDSPSTDDWTENSEAKDESLNSLLGNMRQAVFPIPRPLEVELDPLIKRTGVVKLFGRTRPTILTREYAESAQYPQRWTESANSPNEMVQVTPDVDGPVGCGMGNVPMQQGFGAHGLKQYDEYEQVPQSPWSQSPAPSPAPRTHAEQNPFFTSHAVDEGAFSKHPPSHDYSNNLPLEAIGIDQSKTVIHIPLLHGGHSHRESSSTVRFPVAIVSMLCTIVPYPPNLRQSLSLLMPHLTNSFCLAQRYSQLEKQLSSKMETPRYGQLLGLGGTFSDASSELELVAGLSGHVSYSVGDNNNPMSASASTNSPSDRSSVKFSPTISAIGTPGFDLGNIGFGSANPSPGVASRQGGEGADSYFNVPQNKSVRDSALQSRPRLFRSKTTNIDSRTTISPEKVAWKSIPSDETNLQDQSFYVASPLQEIRPPNVLSPTQQSSRHASTNSLYAQLQRELPRPFSDTIAQLMLNSIPLHLFLAKPESGEVIWTNSKFDAYRRSQHQEQKFRDPWQNIHSSESEHVHTKWANALRTGAQFTERVRVRRFNDESAYRWFIFRANPLLSSTGEVLYWIGSFLDIHEQHIAELEATQEREKFAIDAKYRAFSNSIPQIVFEATENRGLIFVNEQWNLYTGQPLEEAHDLGFAKHVHPDDLEKCGELSLNKTSQNAERSDGGPYEFMVGTALDELVRRGIASLQQDENGRVFYSTEIRLRSRGGDFRWHLVRVVRVKTSSFGSEEASWYGTCTDINDRKNLERELNKAMQQLNHQMESKTKFFSNMSHEIRTPLNGILGTIPFILDTQLDSDQRRMLDTIQNSSTNLRELVDNILDVSRVEAGKMTMVKSWFHIRSMIEDVIDTIASRAVDKGLEINYLIGKDLPSMVIGDRFRIRQVLINLLGNAVKFTAHGEIHICCDMYRDPAANPNDTQAYMNFEVVDTGKGFSSQDAERLMQRFSQLGENGTQQHAGSGLGLFLSKQLVEMHGGKLTPSSKEGQGAKFSFNVKVDAPPPPSPSEQPKLMRQGSGASRRPAKSRTTSYPQAPPLAARNSDSSSKSSDTTLSASLSVTSSALPTPDIGPAPLSSPLEQTTDLTNLADAVSSSRTQPAVTKPDEPVSVVSPESASPDTPVGPVSAPVHGPFSIVILCPLKNSRHAIKQHIEQIVPHEIPFEVTALHDVDEWKDVMQSTSDAHPCTHLVLNLSTDDILEVIQNMSDPGLNPAPVIVIISDLYQKRQISSQVKELAASGKQVFIVPKPIKPSAFSTIFDPKSKRELSKDRNQDMAREINNNFKTVSKMVKEVLGNKGYRILLVEDDETNRDVMLKYLDKIKLMSETASNGLECTNMVLSKEPGYYSLIICDIQMPIKNGYDTCREIREWEQKNHYPQIPIMALSANAMTDQIENAARAGFNDYVTKPIKHNELGKMMMGLLEPGRPLMLLRDRLSPEQQQAIATRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W6PYA1</accession>
    <name>W6PYA1_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Class II aldolase/adducin N-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g002806</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PYA1"/>
    <dbReference type="STRING" id="1365484.W6PYA1"/>
    <dbReference type="OMA" id="LMERSCK"/>
    <dbReference type="OrthoDB" id="3238794at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.225.10:FF:000009">
        <property type="entry name" value="Class II aldolase/adducin N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="entry name" value="Class II aldolase/adducin N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051017">
        <property type="entry name" value="Aldolase-II_Adducin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004855">
        <property type="entry name" value="PRK06208.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10672">
        <property type="entry name" value="ADDUCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10672:SF25">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 14 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="AraD/HMP-PK domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Class II aldolase/adducin N-terminal" evidence="1">
        <location>
            <begin position="56"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM28995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="290" mass="31673" checksum="ADFCC686F19F4492" modified="2014-04-16" version="1">MAPSATVALVDSSSTLPTKSMDGDVDAMASMAHRGKSLPGIPKFSTHAETRQWQLEHMAAAFRVFAREGYAEGISGHISVRDPEWTDRFWINPLGVHFGLLKASDMICVDIHGEVVAGNTAGSINAAGFQIHSAVHRARPDVHAICHTHSVHGRAYSAFARPLEMINQDVCYFYNAHSVYSDYGGIANEASEGQKIAESLGETGKAAILMNHGLLTTGYTVDEAAFLFCLMERSCKVQLLADSAGHKKHIVSDDEAAYNFKMASTPDTLYVEFQPHYQYEEALSNSSFKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W6PYB4</accession>
    <name>W6PYB4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S01g002826</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PYB4"/>
    <dbReference type="OMA" id="AHPTANF"/>
    <dbReference type="OrthoDB" id="4364670at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004879484" evidence="2">
        <location>
            <begin position="18"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="139"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM29015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="190" mass="18737" checksum="A8F485602B021E68" modified="2014-04-16" version="1">MHVSYISLAFFAVGAIAAPAAPKPSNDFGDITGGFPFNPTGSSSIEDSDEGFGNSFPSALDAMHQALAEKQQSAEAAQHASTSHTAVPKSTHAVQNFPAPVVSQASSLSQATPLASQAPVISKAASTTAIPTPSHGVIPTPKGSSASPSSSATPSPSPTAPAGPLSGLVNGIPIVGGLVHGPLAGLGLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2024-10-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>W6PYI4</accession>
    <name>W6PYI4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S01g000833</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PYI4"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM27024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="78" mass="8830" checksum="2CC57699AD1AA8E0" modified="2014-04-16" version="1">MLAVLPILCPVAQTWQHLSKECDMPVIWALQTLLATPTFYEALTKLKNLQTLAMRDTLRPTNEYTPQAALLAVLTEIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>W6PYN9</accession>
    <name>W6PYN9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="11">FAD-dependent pyridine nucleotide-disulphide oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PROQFM164_S01g002952</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM164</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PYN9"/>
    <dbReference type="STRING" id="1365484.W6PYN9"/>
    <dbReference type="OMA" id="PRCTHYG"/>
    <dbReference type="OrthoDB" id="6029at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03478">
        <property type="entry name" value="Rieske_AIFL_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="entry name" value="Rieske [2Fe-2S] iron-sulphur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050446">
        <property type="entry name" value="FAD-oxidoreductase/Apoptosis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43557">
        <property type="entry name" value="APOPTOSIS-INDUCING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43557:SF2">
        <property type="entry name" value="RIESKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="FAD/NAD-linked reductases, dimerisation (C-terminal) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="ISP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="6" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="10">
        <location>
            <begin position="30"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDM29140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="551" mass="58999" checksum="A2EF23397C3CF26F" modified="2014-04-16" version="1">MPQEYKLKDISSFASLNSLDKVEVEIEGIEDGKVLLVKLNDKVYALSPRCTHYGAPLKNGVVTAEGRITCPWHGACYNVATGDVEDAPAPNALNKFEVFERAGGVYILAKEEDVKAGQRNPVVKCTVSQPKEKVVVIGGGSGTLGLIQALRELKYPGAITIISKEPDLIIDRTKLSKALITDAAKIQWRPREWYAEAAIETITDEVTAVDFEQKSISTKSGQNIPYTKLVLASGGTPRRLPLQGFKGELKNVFTLRTIQDVRSILAAAGEERRNIVVIGSSFIGMEVGNALSKSHNVTIVGMETSPMERVMGAQVGRIFQSNLEKAGIKFHLSANVSHATASSSDPHTVGTVHLKNGTSLPADLVIQGVGVRPATDFLHDNKSITLEKDGSVKTTPHFVVPGLQDSVFAVGDIATYPYHGPGADPAGSPVRIEHWDVAQNAGRAAARAIVHALCGPLSSLKHKVFIPVFWSALGAQLRYCGNPINGYDDVILQEKGEAKFVAFYTAGETVVAVATMGVDPVMVKSAELMRVGKMPSKGDIAGGTDVLSLKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W6PZ19</accession>
    <name>W6PZ19_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S01g002787</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PZ19"/>
    <dbReference type="STRING" id="1365484.W6PZ19"/>
    <dbReference type="OrthoDB" id="5979581at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM28976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="111" mass="12560" checksum="4CD61CE9C53B49CF" modified="2014-04-16" version="1">MTANSSISRELHILKFLERQCRKGLSANYIVQLLDAFIHIGPNGTHQCLVFELLGLQLLPKAIKFIHSAGICHRGNELPAQLIKAAEWTEWIDEDDEDIRLLNFGESSYQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q011</accession>
    <name>W6Q011_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Peptidase C48, SUMO/Sentrin/Ubl1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PROQFM164_S01g003437</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C48 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q011"/>
    <dbReference type="STRING" id="1365484.W6Q011"/>
    <dbReference type="OMA" id="ESAHWYV"/>
    <dbReference type="OrthoDB" id="442460at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070139">
        <property type="term" value="F:SUMO-specific endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016926">
        <property type="term" value="P:protein desumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.395.10">
        <property type="entry name" value="Adenoviral Proteinase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003653">
        <property type="entry name" value="Peptidase_C48_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051947">
        <property type="entry name" value="Sentrin-specific_protease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46896:SF3">
        <property type="entry name" value="FI06413P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46896">
        <property type="entry name" value="SENTRIN-SPECIFIC PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02902">
        <property type="entry name" value="Peptidase_C48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50600">
        <property type="entry name" value="ULP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin-like protease family profile" evidence="7">
        <location>
            <begin position="698"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="15"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="83"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="165"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="335"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="552"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="606"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="816"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1078"/>
            <end position="1184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="84"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="104"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="225"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="256"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="278"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="296"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="362"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="383"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="614"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="830"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="856"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1080"/>
            <end position="1091"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1170"/>
            <end position="1184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM29625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="1184" mass="133396" checksum="01FA0B3A13E53F98" modified="2014-04-16" version="1">MPVFKNLVELFSSLSPRRKRETEDQRSALQRAQPPLSTPPRSRPAGSGRNPFILAPDEPDLTETISPQNAAIAPLSTVVHSYVDSFSSPTGSTTAEEPLRTRFSHPSLSPITRPGDSSQMLNKDQQTDSQNRKDEARLLGGRYHDSNAVKIKLGASLNARKKIPGSTFAFSPRDKISQNQNTRSSGPVRSYGEPNQQTSRRKSPQFEDEFEESNRPTKMRRQSKTNETVDLTAPTKSARNRLEQGLYRHPNAIRRNRLEGSRDAEDSVKGAAQSSNRPRHDQLSSVDSRDEMFTETAAQQRRNQADSRLSNVNGKLNQAAEAVVIGSIEVGPKRADRNRTAVPTSIHRPVNGRESPDELQGDITTQPVPRSLSGTQLQATRPSKPEIHIETSTRKRSPSATRSPDFSPPTPVMKKAKISQKNSDKIHLVRYFRIGTFGKSCDSRQFVPIYLTKDGFELRENALGQGNTISIPFHEIRQIVVGETPSRKVRIKMLQSAVKEDDQLDVEFWTTDEKRNFLEVLKQAKQAQRPTKDMKWMDKAFLKYEKQFPRENKRPKKRLLDDLVDDPDPEHSPPPSRRPKLSKSLRDDHGEVNNVNSLEIKCAAQEKVKHGNGNVDSRTSAKEQQNSRPLDTDSGADSRSTVNPLERETRSSTRRGAKKLSNGDVISEAKSNSFPRDDSFRKNWKKPLVYPRNGKKKAEVTLVDRERLLRDDFLNDNLIALYMRFLQDHLERTNKEAAKRIYFFNTYFFATLTNTPRGDRGINYSGVEKWTRNVDLFSYDYIVVPINENAHWYVAIICNLPSLSLGSADAVESVRRPALQKESSNASESEIQEIEETPEPELRSKSELNGSSEANQPREIREGSETRGQTEGDEHAMKPEEQSASDNSLPPPNLSKFAGQKLAQDQAAASQPTTKSKKKRSGLKLDPNQTTIVTFDSLDMPRSPTIKILREYICREAESKRGVELDPNDVKGMRARDIPLQPNFWDCGLYLLAYLEKFVQSPDWFITKVLQRSMNSVDDWPPLGSGLLRYRFGKFLDDLYEEQRQAGEPIMAVRRPISFLLGPPLPCQDEIADVDVVPESQHETDSSRDIAKPVNSKTEDSSEDSTAEQMHLLPTENLPKPKDPKPKTSPSNPPADAKSQNDHVAPAKGEPIIQVPGSQEEPEVPGTPSPKKKERRKHGHSRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q030</accession>
    <name>W6Q030_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S02g000022</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM29873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q030"/>
    <dbReference type="STRING" id="1365484.W6Q030"/>
    <dbReference type="OrthoDB" id="4187177at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM29873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="282" mass="31494" checksum="301400310BAA9EFE" modified="2014-04-16" version="1">MALAQKTAKASSSPCPQGLTPPGSPTKESTMPPATLKDLMLLFGVFLESALLDLADQEPPNTPVSQDQSPPGLDIGRLKRLMVKLTHDEYASAELSLATKPARSSSASNEREGNAQAVDEIDLESPICTTPDDFKSFEKWASKSQFKTVMETWDKEACKYKIVEPTETSNDLDDYAEYAFVVRERVDRTSKEIVSFIDIKSEGLRDSLRDVLHDIKAVSLMEIKPSIEQNFLFHFLPELDRCAENMDSSSDHESAYAEHLLLLINYLKHAYASTLQRLESML</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q0P8</accession>
    <name>W6Q0P8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S02g000272</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q0P8"/>
    <dbReference type="STRING" id="1365484.W6Q0P8"/>
    <dbReference type="OMA" id="CAPDDWN"/>
    <dbReference type="OrthoDB" id="2507140at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004879521" evidence="2">
        <location>
            <begin position="21"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM30123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="187" mass="19906" checksum="6510A4255461F981" modified="2014-04-16" version="1">MHYLKPILPFILAAATFASAATTTATLADNAMNTTCVSDNILQQCVQPMQSTLANCAPDDWNCQCTSSTNILDCYDNCPNDTSRKDAESMRQQNCANAKAHVPTSISTAASAISSSRAAATRSTDIEDGTEISDSEAENEFKEHPIKQYSGLEANSIPRPEQGSASVLRMGGCLSFLGLALSIILSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q0U7</accession>
    <name>W6Q0U7_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Zn(2)-C6 fungal-type DNA-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PROQFM164_S01g003408</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q0U7"/>
    <dbReference type="STRING" id="1365484.W6Q0U7"/>
    <dbReference type="OMA" id="MLLYSMM"/>
    <dbReference type="OrthoDB" id="5426798at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF11">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="272"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="304"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="348"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="99"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="193"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="308"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="348"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="366"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="390"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM29596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="923" mass="102450" checksum="49CFD7F170D16024" modified="2014-04-16" version="1">MPTSQGSRGSGSGSAIGPRCYVGPFGRMLPIDGPSSEQQPELPANLQETGEHLYQLPPPRVPTSLQFGSDPFPRQKNSPERKDSGSESQKPEQLPSVRQILTPTPGTNSLQYSQPFASSTLNTGRRGSAYPHYHDPTFQVPSSAPDRGRAESLPQLHGLPSLSQVGLQGHRGIRSQTPTRSDPPAASFIQLPFHTSSHGQIPNGELSSPESSKRSNNQPLRPHVVDERVIDGELCFVYADGSSCPKFIDGTPVNANWGITKAGRPRKRLGLACLTCREKKIKCNPNPTAEAVCDQCRKSGRECRFESAPRGSRPPMRGPSGRPDSYAPTSHGALDVSPSLYDITRASDSATSLPGTTGHSPMPESSMKTPSSQEATYETMTEADRGLRSRSYQFPSPLSGTDETLGRPSPHAESVRSPEYSDILGKLKDSNSDDPLAASWNLDPYESDPESVAHYTECYFSHVNDGMCHMFPRGRFSSWLKTCPIKSAHDKMLLYSMMALGSVFSDRPEKMAAMTRYSRIARFAINRSQHTLSLQLAQSHIIMSLWYYATGSLVGSWDSIGAAGRAVFGLRYNVESGGVVVDHSQVCEYGLHPQALIECRRRTFWIAFVLDRFSSLYSASSTFISSDAALLRLPCREEIYETQQSWLFGGDISLHITRLPHIPLEAYNRLAEEFNTTIVQKSNQWMTRLPEYLAFSPTNLERSIHQKNADTFISTHLFYHVSLMKLYRHARYQSLQPEILSQYIHRARYHAVEILRISLTFDQCAKKLTPSRNNTETSISKLTPLNPFLGYVILSAVDVLSSAGLASQLHECIYYIRGALDAVHELGRYWDSSLQLVTVLHRRLSLMMTCLNERSVFAEKQGFALDGPPLETKVHAGALHSHPPSTTGDDLFTGSMPREMILNALRLDETLISESRITWIRDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q0W6</accession>
    <name>W6Q0W6_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Septin homolog spn4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">spn4</name>
        <name evidence="6" type="ORF">PROQFM164_S01g003423</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q0W6"/>
    <dbReference type="STRING" id="1365484.W6Q0W6"/>
    <dbReference type="OMA" id="EASHAEI"/>
    <dbReference type="OrthoDB" id="416553at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032156">
        <property type="term" value="C:septin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01850">
        <property type="entry name" value="CDC_Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000238">
        <property type="entry name" value="Cell division control 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016491">
        <property type="entry name" value="Septin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18884">
        <property type="entry name" value="SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006698">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51719">
        <property type="entry name" value="G_SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Septin-type G" evidence="5">
        <location>
            <begin position="1"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="284"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDM29611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="351" mass="40911" checksum="E7BD3EA208A02D2B" modified="2014-04-16" version="1">MVAGESGLGKTTFINTLFSTTIKNYADHKRRHQKQVDRTVEIEITKAELEEKFFKVRLTVIDTPGFGDYVNNRDSWQPIIEFLDDQHESYMLQEQQPRRTDKIDMRVHACLYFIRPTGHTLKPLDIEVMKRLSSRVNLIPVVAKADTLSHADLVRYKDRIRAVIEAQGIKIYTPPVEEDDEHAASHARSLMAAMPFAVIGSEKDVKANDGRVVKGRQYAWGVAEVENEEHCDFKKLRSILIRTHMLDLIHTTEESHYEAYRAQQMETRKFGEARPRKLDNPKFKEEEETLRKRFTEQVKVEEQRFRQWEQKLISERDRLNKDLEATHAAIKSLEQEIEGLQGSGTRSHGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q0X8</accession>
    <name>W6Q0X8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PROQFM164_S02g000114</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM29965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q0X8"/>
    <dbReference type="STRING" id="1365484.W6Q0X8"/>
    <dbReference type="OMA" id="ASWTLKC"/>
    <dbReference type="OrthoDB" id="66881at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000228">
        <property type="entry name" value="FAD-containing monooxygenase EthA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051820">
        <property type="entry name" value="FAD-binding_MO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43872">
        <property type="entry name" value="MONOOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G02570)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43872:SF1">
        <property type="entry name" value="MONOOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G02570)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM29965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="501" mass="56544" checksum="7C588C435C393236" modified="2014-04-16" version="1">MSGLDETNEARHFDVIIVGAGISGVNAAYRVQDQLPGYSYTILEARADLGGTWDLFNYPGIRSDSDLFTFGFQFNPWTLDNPIAEGSAIKQYVRDTATKFGIDKHILYNHRVSSADWSSDKNIWSLAVDHNDSEHTYTARYVIFGTGYYNYKDPLKADIPGLDAFQGQVIHPQFWPEDLQYKDKTIVIIGSGATAITLLPNLADDAARVTMLQRSPTYILSVPNRSSNRWLSYILSNALYLRLQRMISIYTTRYFFLFCQRFPNFSRWLLKLNVRKQLPSHIPYDPHFKPKYNPWDQRLCVCPDGDLFRSLRQGKADVKTDTIREVTKNGIILNSGEQLEADIIITATGLRLQIVGGAALSVDGKKIDVGGKYLWNGVMLQDMPNAAFVIGYTNASWTLGADATAHLVCRLLKELESRKLVAAVPRLKEKDAATIQDRPLLNIKATYVSLADRILPRAADRGPWRPRDNYLSDLKFAQSGDIETGMEFVQGPNLRLRPKMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q1W2</accession>
    <name>W6Q1W2_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Calcium/calmodulin-dependent/calcium-dependent protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S02g000125</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM29976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q1W2"/>
    <dbReference type="OMA" id="IEMRYMS"/>
    <dbReference type="OrthoDB" id="1668230at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF291">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM29976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="266" mass="30034" checksum="7F0167E3F899AF5E" modified="2014-04-16" version="1">MRALYHLIDDEGHYIKPHTILATGDAAVVVQREDVAIKMAVVYKNNTLEEVEQNRSKIRREQEVWRRLQPDFNTPVEGIVHCLDLPGDTIEMRYMSGGTLSKWLRHRARPSIELQKRWFRQLAIGLHNLHQSCVIHSDILSRNILLDGSLNVAICDLGASSIMPIDAVLADAVDDYNCSIWTDLCQLGIVFYEIATGRRTSVSLYHHSGSDDSVARFPSRDMLPALGKQIWARDIIETCWREGGYGAVGAVGILAKLDKMQGSRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q3G9</accession>
    <name>W6Q3G9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PROQFM164_S02g001005</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q3G9"/>
    <dbReference type="OMA" id="YINLCLG"/>
    <dbReference type="OrthoDB" id="419537at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015174">
        <property type="term" value="F:basic amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000024">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF67">
        <property type="entry name" value="MFS MULTIDRUG EFFLUX TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="104"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="142"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="197"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="233"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="264"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="305"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="331"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="374"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="409"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="439"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="465"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="504"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="571"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="107"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="76"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM30855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="603" mass="65225" checksum="BAC2A24E8851ACC9" modified="2014-04-16" version="1">MTSDNEGQSCPSEATPLLRKNSVHRKTSYHDVSYSATDVESVCSYRDTVEEEANVRCISSASSVEGLDVGPASGAGSPNQQPNISTQDGKDYASRFIDISPTRFWIIFSGIMMGYLIGFFDSTLMASSHPVITSYFEAANSASWLSTAFLLTSTAFMPLLGRISDAFGRKPVYLFSIAMFFLTTAGCGLAQSIGSFIAARALCGLGAGGIFSIGQIISSDLVRLEYRGVYQSYINLCLGIGGSLGLAFGGYLCDHIGWRGAFLIQLPFIFVYFIAAAWTVPADLGIKQTGMERMKVWQLVRSIDILGSIILIICVTLLIMGLNFGGNVYPWSHPLIIISLVSSLVLAVILVRYELHVPRPVLPIELMATDPRASIIFGNFFASMSVHTMLFNAPLYFQAVKLTSPTASGLRLVASSIAVTISSVSTGFMINWTRRLKPYVIIGVCCMVIGGCAAASMGIDTSQPLSMICISFSSLGQGFAFPSLMVSILATSEKQDQAVATTTLGLWRNLGAVMGVAVSSWIFQNSLIYQLNKNVTGFEKNHIIALVRKSVDTIAHLDPIHRREVTLSYSAALQLTFISAALWAVIVLILLGRVRLPRLGRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q437</accession>
    <name>W6Q437_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Multi antimicrobial extrusion protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PROQFM164_S02g000871</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1365484.W6Q437"/>
    <dbReference type="OMA" id="AAWFELF"/>
    <dbReference type="OrthoDB" id="2126698at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:antiporter activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990961">
        <property type="term" value="P:xenobiotic detoxification by transmembrane export across the plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13132">
        <property type="entry name" value="MATE_eukaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045069">
        <property type="entry name" value="MATE_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11206">
        <property type="entry name" value="MULTIDRUG RESISTANCE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="119"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="185"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="213"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="260"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="305"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="337"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="374"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="408"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="437"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM30721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="475" mass="51567" checksum="2C1B2E001D01C054" modified="2014-04-16" version="1">MISEDHGGIEYSPLLRNIDPEAADNSKKSGWRQELAIISRYSAPLMISLLLQHALTGSSIFMVGHLGKREIGAVSLANMTSQITGYFVFQGLSTCLDTLCPQAYGSGNLTLVGLHVQRLTLFMIVLTIPIGAVWWNADRIFLLILPSEAQETALLAGLYLKIAIAGAPGYACFESGKRFFQAQGLFSASLLVLVLCSTLNIFMGWLFVWRLQWGFVGAPIAVAVANSLLPIFLAFYAIFIKGSECWHPLSAKMWRSWGPMLKLAIPSWLMIEAEVLAWEIMTLISSHLGATELAAQAAISTLSDFAFQISFSIAVAGGTHIAYLIGAGLPQRAATSANVMVFASFGAGITNMLVILALRSVIPGLFSDIGEVWHLIFFLLPVGAVLQIPDAVATSLNSLLRAVGRPDLGSYVQLSIYYLVGLPLGIALAFGLGWSVFGLWCGIFIGQSIIVLIEGFYFWKMVDWAKASREAVERM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q488</accession>
    <name>W6Q488_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PROQFM164_S01g002785</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q488"/>
    <dbReference type="STRING" id="1365484.W6Q488"/>
    <dbReference type="OMA" id="RSIHWMA"/>
    <dbReference type="OrthoDB" id="9986881at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF138">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="153"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="187"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="217"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="247"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="279"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="353"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="392"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="430"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="457"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="490"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="526"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="122"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM28974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="576" mass="63577" checksum="9BA7A7850CDEECE1" modified="2014-04-16" version="1">MSHRSHSPHDSISSGSDDLSTIPTIDDRRLSEAGPMPSGGLTHRQSNPNEVELERINTYRLQQRSTVGSGIGITPRDQWLPLGAGKPHPPSLPDPEQYVVEFNDADDPMHPQNWSLASKIGISVTLAYTTFVSSFASAIFSSTVGHVSAHFHISTEVAVLGVTLYVLGFASGPTVWAPASELIGRRWPICVGMFGYSIFSIAAATSKDVQTLMISRFFAGFFSASPIAIVPAVYADIWNNQTRGVAIAMFAMAVFVGPFASPFTGGFITMSYLGWRWTMYISSFMGWLATGLCLLFLKETYAPAVLVEKAVILRRQTHNWGIRARQEEIELDWGDLITNNFSRPFRMLFTEPIVFLISLWMSFVYGLMYALLGAYPVVFQGIHGMNLGVGSLPFIGLIIGEFLAGAYLLYDQRAYTKKLAANNDMPIPEWRLPPAILGGICFCIGLFWYGWTGWTKSIHWMAPTASGIMTGFGIYVIFLQCFNYLIDSYLTFAASVFAANTIIRSAVGAAFPLFSKQMFINLGVQWAGTLLGCLALIMIPIPLLFIKYGPALRKRSKFAPVFERPLPSRSEKTESV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q4D3</accession>
    <name>W6Q4D3_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transcription initiation factor TFIID subunit 10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PROQFM164_S02g000936</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Functions as a component of both the DNA-binding general transcription initiation factor complex TFIID and the transcription coactivator SAGA complex. Binding of TFIID to a promoter (with or without TATA element) is the initial step in pre-initiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation by TAF1), facilitation of DNA opening and initiation of transcription. SAGA acts as a general cofactor required for essentially all RNA polymerase II transcription. At the promoters, SAGA is required for transcription pre-initiation complex (PIC) recruitment. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction (via core/TAF module) and promoter selectivity, interaction with transcription activators (via Tra1/SPT module), and chromatin modification through histone acetylation (via HAT module) and deubiquitination (via DUB module). SAGA preferentially acetylates histones H3 (to form H3K9ac, H3K14ac, H3K18ac and H3K23ac) and H2B and deubiquitinates histone H2B. SAGA interacts with DNA via upstream activating sequences (UASs).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the TAF10 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q4D3"/>
    <dbReference type="STRING" id="1365484.W6Q4D3"/>
    <dbReference type="OMA" id="QNGSQEH"/>
    <dbReference type="OrthoDB" id="154356at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990841">
        <property type="term" value="F:promoter-specific chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003923">
        <property type="entry name" value="TAF10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21242">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21242:SF0">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03540">
        <property type="entry name" value="TAF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017246">
        <property type="entry name" value="TFIID_TAF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="172"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="29"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="48"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="172"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="200"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR017246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM30786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="239" mass="24343" checksum="81553EEB180F5776" modified="2014-04-16" version="1">MADSQTSQPSQPIPQNGSQEHPPPTESEDNIKTEPDLDVSIEKDVDMNTENQTEANANTTAPGQDPMAPAPEPSKKETSLREFLGKMDDYAPIIPDAVTAHYLTLAGLPPPGTGPGQTPPHLARLLALAAQKFVSDIAADSYQFARIRASNSSSANNPIGSLAAAAGLGAPAGAGGAPAPGGDGGKGNKAGTHLGIQRPGFGGGGSGGSGQGRTVLTMEDLGMAVSEYGVSVKRGEFYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q4G4</accession>
    <name>W6Q4G4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S02g001673</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q4G4"/>
    <dbReference type="OrthoDB" id="4139357at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM31523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="85" mass="8659" checksum="ED36677627FB82F9" modified="2014-04-16" version="1">MTAGFQVIAGIGIGTIFSVPPIPMQASAAPDDQGLAMGIMVAFRLFGALIGLAVDATTFSSVFANRISGIDLPASLALLKDPVRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q4W7</accession>
    <name>W6Q4W7_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S02g001525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q4W7"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="5"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM31375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="70" mass="8309" checksum="4BDA81DDEDC559EE" modified="2014-04-16" version="1">MYKKIVGGCIRLFVVVFVIIEIENYTNLIDRYPIACKVAFFLALFGFLWLYGMYRDPESELNQDDKDPRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q5D4</accession>
    <name>W6Q5D4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S02g002014</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q5D4"/>
    <dbReference type="OMA" id="CNSADER"/>
    <dbReference type="OrthoDB" id="5239190at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM31863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="106" mass="12159" checksum="1EEDBD61DDE235C1" modified="2014-04-16" version="1">MGNDRGRNKGRGRGKKRSHIHSLKENTVATTVATKLDNKPKGKISDKHHCLSKRPEHVRTSRCLRLGHVVQCPIHSDSFPLRLSECVKCNSADRRQVQQERKDRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q5G2</accession>
    <name>W6Q5G2_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycosyltransferase, DXD sugar-binding motif</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S02g001725</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 32 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q5G2"/>
    <dbReference type="STRING" id="1365484.W6Q5G2"/>
    <dbReference type="OMA" id="KMRDWHW"/>
    <dbReference type="OrthoDB" id="409543at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000136">
        <property type="term" value="C:mannan polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000009">
        <property type="term" value="F:alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007577">
        <property type="entry name" value="GlycoTrfase_DXD_sugar-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039367">
        <property type="entry name" value="Och1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31834">
        <property type="entry name" value="INITIATION-SPECIFIC ALPHA-1,6-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31834:SF9">
        <property type="entry name" value="INITIATION-SPECIFIC ALPHA-1,6-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04488">
        <property type="entry name" value="Gly_transf_sug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM31575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="399" mass="46246" checksum="165AFDA7545420AB" modified="2014-04-16" version="1">MRNRVFLGFPNRHKYALVAAILTLFILFKSVPTSKLDPHTKKLYGEDRPRYLHQSTFRKNPDHDYELKLSNALRAMEIEREMRHDEDATHTLWQIMLPGVSQRSDDSIQFEEKNSEWKYKLIEADWADKFIFDTLESIPDIARLYKSYPHSVHRGDLLRYLILWYYGGYYADLDIYPARSIKSCPSLRDSIFKANTVNANVSLVVGIEIDEPFASPQKMRDWHWARRYGFIQYSIYAPQRFSPLLREIIVRVLSHTKQRVDEGHFWNRRYNEMDTMEITGPGVFTDAILDVLSDTLPSTHRLVQQSVDADAGFSSSASSVQRVTWAPFHGIQEPLCVESSETQPGKLMGGLCVLPVNAWGNGQRHSGSEGFSSQQACINHRFGGTWKPWKQSWRKYLFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q5H0</accession>
    <name>W6Q5H0_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">diacylglycerol cholinephosphotransferase</fullName>
            <ecNumber evidence="9">2.7.8.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PROQFM164_S02g002059</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>CDP-N,N-dimethylethanolamine + a 1,2-diacyl-sn-glycerol = a 1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33775"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:64572"/>
            <dbReference type="ChEBI" id="CHEBI:65117"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:33776"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="8">Phospholipid metabolism; phosphatidylcholine biosynthesis; phosphatidylcholine from phosphocholine: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.2" evidence="9"/>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q5H0"/>
    <dbReference type="STRING" id="1365484.W6Q5H0"/>
    <dbReference type="OMA" id="QNMGQGW"/>
    <dbReference type="OrthoDB" id="196717at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004142">
        <property type="term" value="F:diacylglycerol cholinephosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1760:FF:000012">
        <property type="entry name" value="sn-1,2-diacylglycerol cholinephosphotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048254">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014472">
        <property type="entry name" value="CHOPT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10414:SF37">
        <property type="entry name" value="BB IN A BOXCAR, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10414">
        <property type="entry name" value="ETHANOLAMINEPHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015665">
        <property type="entry name" value="CHOPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="142"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="167"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="260"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="293"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="323"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="355"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00051857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDM31908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="410" mass="45919" checksum="C4613877FF5B9746" modified="2014-04-16" version="1">MVYIRQHELANLKNYKYAGVDHSPVSRLILKPFYNKFVIRCFPMGMAPNAITLTGFMFVVINFVTVMWYNPNLDTDCPPWVYASCAIGLFLYQTFDAVDGMQARRTRQSGPLGELFDHSVDACNTGLSVLVFASAMNMGQSWMTFIALFGSTITFYVQTWDEYYTQILTLGVISGPVEGILTLCTVYLFTAYMGGGSFWHQSMLETIGVPKPSFLSSQVYNMPFTQWYLVYGSVVLCFAIGSSIMHVMKVRRERGQDPFTPLYGLLPLVAIWSPIFAYLYLQPMILENYTIPFGLFVSLVNAYSVGRIIIGHLTQTSFPYQNVLLYPLALGVLDSAGALFGLWSAPVLGYGVGQVAFVFGLLGLAVGIYGSFVFDIITTICDYVDIWCLTIKYPFVEETERKTGLSKKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q5Z3</accession>
    <name>W6Q5Z3_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Beta-ketoacyl synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PROQFM164_S02g001561</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM164</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1365484.W6Q5Z3"/>
    <dbReference type="OMA" id="KMRGGEF"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901336">
        <property type="term" value="P:lactone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05195">
        <property type="entry name" value="enoyl_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000209">
        <property type="entry name" value="Polyketide synthase Pks12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056501">
        <property type="entry name" value="NAD-bd_HRPKS_sdrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049552">
        <property type="entry name" value="PKS_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF28">
        <property type="entry name" value="SYNTHASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23114">
        <property type="entry name" value="NAD-bd_HRPKS_sdrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21089">
        <property type="entry name" value="PKS_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="11">
        <location>
            <begin position="13"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="12">
        <location>
            <begin position="899"/>
            <end position="1182"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="10">
        <location>
            <begin position="2358"/>
            <end position="2434"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="8">
        <location>
            <begin position="899"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="8">
        <location>
            <begin position="1038"/>
            <end position="1182"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="8">
        <location>
            <position position="931"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="8">
        <location>
            <position position="1098"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDM31411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="2446" mass="267732" checksum="60253EA408C52153" modified="2014-04-16" version="1">MILKVVEPKPVPPEPIAICGMSVRLPGGLHTPQQLWDFLVAKGDARGQVPKSRYNVSTYYSETQKPGSVKTEYGYFLDESIDIASVDTSFFTMGKLEVERMDPQQRQMLEVARECMEDAGETNWKGRPIGCYMGSFGEDWLEICVKETQQYGQHRVSGYGDFMLPNRVSYEMDLTGPSMVVRTGCSAGIVALHEACLAISRGDCESAIVGGANLIMAPGMTAAMSEQGVISPDGSCKSFSADANGYARGEGISAIFIKPLADALRDGNPVRAVIRSTSSNSDGRGAGIGAHVPNDVSHEAMIRRAYEVAGITDYSQTAFFECHGTGTQVGDPIETRAVGRVFGPSGGILIGSVKPNLGHAEGASGITSLIKSVLALENRTIPPNIKFKERNPNIQWDEYGLAVPTDPMPWPEARSERISVNSFGIGGTNAHVIVDSARSFGVSPVATRHTISPQLLVYSANNAESLKQMISHYTSYVQKNPARVADLAFTLANKREHLPHRAFSVQSPLGPLTTSAPSKTGETPNIVMVFTGQGAQWPQMGASMIHNDVYPAFKKSIQNLDSHLQTLTDAPDWSIEEELLKDPDTSRLSSSELSQPLCTAIQVALIDTFASVGVQPAAVVGHSSGEIAAAYAAGAITATEAITIAFYRGQVTKAQTRPGSMAAIGMGAEDIQEYLQDGVVVACENSPKSVTLAGDTHAIEKVVAIIKEAHPDVLARQLKVDKAYHSHHMAEIGDEYHALIEHEISTKAPNKLFFSSVENELLTEAQHLGPKYWQMNLQSPVLFRSAVSSIIKHQISKNMVLLEVGPHSALAGPLRQIQSHLSTSSPYISTFVRNQDSTESFLTAIGQLHVLNAVPALDKVISTGSTLPDLPRYPWDHSKKFWYESRLSKEWRHREHKYHDLLGVRVTESPDFHPLFRNLFHLDNAPWIRDHKVGDDIVFPFAGYAAMIGEAVRQVTGVREAFKLRNVIVSTALVLNEGPPVEIMTTLHRHRLTDSLDSEWWEFAITSHNGANWIKHCSGEVRSLNEYLEDVDKKAPLVRKVETRRCYHSMAMSGLNFGPSFQRLDHVRSDTVSQSATSELVAKDTDGDNYHLHPTVIDASLQLLSVAASKGYAEPITNIMVPTHIQEISIYRCYENVHVQASASYTPNGSIIGSGQCITAGGKVALRSSGIKLSVLDHQDPEKGEPPIGCAEWAPHIDFLDVNTLIKPLIDRSDYMPALTELSHLCMIYTQRVIADLDTPISHMYKYRSWIDQHLLSVDLQSLQILDNIAIKQRVKELVDQISQTNGAHLAVGIEVIFNNVQQIFTGEAEALDLLLTDDILANVYNAMDQCDISEFIRNLTHTKPNLRILEIGAGTGGSTANILKLLTPGSRTLYMNYTFTDISSGFFVAAKDRFASYPNIEYATLDISKDPSDQGFDDRKYDLILATNVIHATASLNDSLSNIHKLLSPTGWLLLHELTPISKWINYIFGTLAGWWYGEVDGRSGEPYIGIERWAKELKAAGFRTPDAAVLDSNQPHQLNAMIVARPEVDIAPKKCVTVLTLSKSMSVGPLLQALDNRGYSVHHSRFDEEPLPEGQDVIALLDEEAPFFEGMDNQRFDSFKKLAHSLDQRGVLWVTRSSQAQCRDPRFAQINGVARTIRNELRVDFATCEVDDLDVSFEKLIDVYEKFQVRQEDETLKPEFEYAIVDNTVQVGRYHPFSAQNGQEALASNSSIALRTSKPGRLASLHWAHGDIKPLEGDEVEIDTYAIGLNFKDVLCAMGIVEAKENEFGHEGAGIVRRTGPDVQSLKVGDRVMVVGSCLFGTQLVLSENLCEKIPGGLSFSDAASMPCVFSTSIYSIFDVGNLKKGQSILIHSACGGVGIATIQLAQMVGAEIYATVGNEEKVRYLMDTFGLPRNRILNSRNASFVEDIMRETNGQGVDLALNSLSGELLHATWKCIAPFGKMVEIGKRDLIGSGKLDMTPFLDNRSYCCVDLDQICSRKPILAKKLLKEIVDLLKERYISPIRPIKVFSSDGIHDAFRYMQQGTHLGKIVVSMRDTSGQVSAVQNIQPRKKPTQLNSSGAYLLVGGLGGLGRAISTWMVQRGARHLIYLSRTAGSSESHREFAQELASMDCRVDFVQGSVSNIADVTTAVTRAQGRLRGILQMSMMLRDRSFERMTLEEWNTSVDPKVKGTWNLHNASVSANAELDFFVLFSSVSGVFGLPGQINYAGANTFLDAFSQYRLGLGLPACAIDIGIVEGVGYAAEQDEILQKLKAAGGLGNTVSVSELLSAVEAAMTSISSNLRPQAGNFGVGIRPNVPLADQRNRLVWKKDIRMSVFHNTGAAGTILTSASDAGAGLEAFITQAKGDAALINQPGSAQMLAVEIGKKVFSFLLKPEEDLVTSCSLSDLGMDSLVAIEVKQWWKATFGFDISVLELMGMGSLDILGEHAAHGMLRLFHGVQDQAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q6P2</accession>
    <name>W6Q6P2_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S02g002166</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q6P2"/>
    <dbReference type="OrthoDB" id="4357639at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM32015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="95" mass="11013" checksum="B7BACB688B297F65" modified="2014-04-16" version="1">MRKNEEILEIFQEIIPAPTKAMLWYFHLTPEHIVALPKADYLLTCCLIQNGRQTSRYESLINLLKTLTINVPSLDSRCFRPQTIWLPQGTALTLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q6Q6</accession>
    <name>W6Q6Q6_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ubiquitin 3 binding protein But2, C-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S02g000088</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM29939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q6Q6"/>
    <dbReference type="STRING" id="1365484.W6Q6Q6"/>
    <dbReference type="OMA" id="RSDSCCF"/>
    <dbReference type="OrthoDB" id="4657524at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054508">
        <property type="entry name" value="PIR1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018620">
        <property type="entry name" value="Ubiquitin3-bd_protein_But2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39613">
        <property type="entry name" value="ANCHORED CELL WALL PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G08960)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39613:SF1">
        <property type="entry name" value="ANCHORED CELL WALL PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G08960)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09792">
        <property type="entry name" value="But2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22799">
        <property type="entry name" value="PIR1-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cell wall mannoprotein PIR1-like C-terminal" evidence="3">
        <location>
            <begin position="64"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin 3 binding protein But2 C-terminal" evidence="2">
        <location>
            <begin position="288"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="154"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="202"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM29939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="438" mass="42862" checksum="87644A4A4CF3949F" modified="2014-04-16" version="1">MKNFITIAAFAASTNALVSRSDSCCFHLTSSGGASGELGQLSDGQNRIGDSSLSPAQYCIDSTGAITDSNGRGCILTPPTTQFQCDEGASPTPGFSLSSQGELEYNGSKDFVACATGQNGGLNVYTAPNKSDVTGCVNVELTADSCSNSGSGSGSSSSSASAAPSSVGSSSAPSTFSSVSSSPGSGSGSGSGSGSGSGSGSGSTAPAPTATGSGSGSTAPAPTATGSGSGSTASVPTGSVPSPSSAGGGSQPSDSNSGSVPTSSASSTTATGSSSSSCPTTLTTGSYEYPHLIVPVDSSSPDTAPGTSYNGTVSSTISSAFNFDIPSSDSGKTCSLVFLFPELQDLETSSYSFSGDGKIDFAKLSSAVDESTTFNNLPSVSQDLGDITVSPGNSYVISTFACPGGQTVAFEMKNSGSTYLNFFEDYNPSPLGLYITTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q6T1</accession>
    <name>W6Q6T1_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha/beta hydrolase fold-3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S02g000113</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM29964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q6T1"/>
    <dbReference type="STRING" id="1365484.W6Q6T1"/>
    <dbReference type="OMA" id="DGALGHW"/>
    <dbReference type="OrthoDB" id="2152029at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF21">
        <property type="entry name" value="LIPASE_THIOESTERASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_8G02590)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="3">
        <location>
            <begin position="114"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM29964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="359" mass="39150" checksum="6727470B5A90DC88" modified="2014-04-16" version="1">MSVTKVTKVNLSIKEKLDFLPAVASIVVAYVYALLTGLRRTERQAKSLSLHLGYALFRKASSRLTATQMQYILPPSHKIYEQHSKETGGLPESVDLGDGALGHWMGDSNADNVVVWIHGGGFGLPANMGYFKFYAQLIHDLEALGKSVAVFSLTYTLAPIAVYPTQLRQAVNCLRYILSQPNRDPSTIFLGGDSAGGNLVGGVLSHLAHPHAEIDPLPFRGNLGGAVMIAPWTLLEKEFPEMEVYSDGDIITMAVAGPWVTAYIGAGKRDYYTDLSTAPADWFTAFPVNSVLITAGGNEIMLPLIQDFAAKFKEGFENVELFVGYRECHVAPIYHLELGDVTKTEQGKKVEAVLAELMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q739</accession>
    <name>W6Q739_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S02g002694</name>
        <name evidence="3" type="ORF">PROQFM164_S02g002914</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q739"/>
    <dbReference type="OMA" id="QRIMTKE"/>
    <dbReference type="OrthoDB" id="4373357at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM32543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM32763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="55" mass="6346" checksum="A5F6B354390CEC8F" modified="2014-04-16" version="1">MRTLKKYYQSSWKLKTDPRPVGSLSWQRGAAEPSPSNNPQVVRNGTPFHTPYEQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q8B6</accession>
    <name>W6Q8B6_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Tyrosine-protein kinase, catalytic domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PROQFM164_S02g002372</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q8B6"/>
    <dbReference type="STRING" id="1365484.W6Q8B6"/>
    <dbReference type="OMA" id="QMARCQA"/>
    <dbReference type="OrthoDB" id="20524at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004712">
        <property type="term" value="F:protein serine/threonine/tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033316">
        <property type="term" value="P:meiotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098813">
        <property type="term" value="P:nuclear chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034501">
        <property type="term" value="P:protein localization to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14131">
        <property type="entry name" value="PKc_Mps1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000377">
        <property type="entry name" value="Checkpoint protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000131">
        <property type="entry name" value="Dual specificity protein kinase TTK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027084">
        <property type="entry name" value="Mps1_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22974:SF21">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN KINASE TTK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22974">
        <property type="entry name" value="MIXED LINEAGE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="476"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="246"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="430"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="22"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="83"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="97"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="121"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="161"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="196"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="258"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="329"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="450"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="504"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM32221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="818" mass="90609" checksum="ACFB5E46253CC6B3" modified="2014-04-16" version="1">MASPNFLPAYNELYRQPPRPMSRSAVSRSGSRRVSPSTQAMSKHYSGDSSDEEVPEPKFSASVKALLHGDGLGSSPHLHKAHVHEPRIETSRHQSRSPRNSSPHDSSNGSPAPRVVRVGALSSSSRFSREGSPLSNSQSAEPEHHSRPNDFITPAPRQRSVRINVSRSNTRSPASVSPSGKRSSERSSDDYYGSAERSDSDRKSQYEDDPALRYGVSSALRGRGGEEFAPHSSLRVKRVGRLAGTFLNGPARRGVLRRQSEESNEENHQYLSADGVREDVEGEEENAEYRPRNSAKPSSPKVSWADPSPPLVRESNRREYPLRPAEVEGPFSRSSSPKSYGSKSTPASSDLSSKSSIAKEQPVFKVPSIPALPSVRDQENEPPPTFRRTKPQGLSMLDKPEKYHVVYDTEKNDIAETPATNSARKILATRSNNTPHRAAPPPPKMSVLETATSTGGASTSQSRKKKSQVSINGKHFTRLDCIGRGGSSRVYRVMAENYKIFALKRVNIEDVDPVTLSGYKGEIDLLKKLENVDRAVRLFDWELNNDKHALSLLMEIGESDLEKILTYRLNAEDAVFDINFTRFYWKEMLECVQAVHEHNIVHSDLKPANFLMVQGRLKLIDFGIANAIQDNTVNVHREQQVGTPNYMSPEALVDSNVSLGLPSSLGKVMKLGKPSDVWSLGCILYKMVYGQPPFAKIAKYYERIMAIPNPRVQIDFPAFGVGGIPVPPGLVRTLKRCLQRDQTLRPTIEEMLGPRDPFLHPDAQLEGAVPVTQDMLGRILVNVVNHCKARGVPREEELAAWPAGFFAKIKAALEEENA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q9T3</accession>
    <name>W6Q9T3_PENRF</name>
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        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S02g003327</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
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                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q9T3"/>
    <dbReference type="STRING" id="1365484.W6Q9T3"/>
    <dbReference type="OMA" id="ACENHIL"/>
    <dbReference type="OrthoDB" id="4322381at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM33175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="160" mass="17664" checksum="E859C55D67DB6C68" modified="2014-04-16" version="1">MENHPHVPEAQRRSMNQYHYQHCGNADAIILANTSFNIPLGGSILTSRPVTPSGGPSIHLAQPPVNAACENHILSACKPDDPSADQRIRENTRLLVDSGIVEKLGTNQALDASPFEVDDTSYMSQDDAETNRKRTQEAHARYWEAMGGIDRVIGKRPHKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W6QA94</accession>
    <name>W6QA94_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Genomic scaffold, ProqFM164S03</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PROQFM164_S03g000024</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792017">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1365484.W6QA94"/>
    <dbReference type="OMA" id="REFWPLF"/>
    <dbReference type="OrthoDB" id="2107885at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
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    </dbReference>
    <dbReference type="GO" id="GO:0005619">
        <property type="term" value="C:ascospore wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005628">
        <property type="term" value="C:prospore membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059112">
        <property type="entry name" value="CysZ/EI24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052786">
        <property type="entry name" value="Spore_wall_assembly"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34292">
        <property type="entry name" value="OUTER SPORE WALL PROTEIN LDS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34292:SF1">
        <property type="entry name" value="OUTER SPORE WALL PROTEIN RRT8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07264">
        <property type="entry name" value="EI24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="153"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="216"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDM33300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="267" mass="30348" checksum="317A51D3E17BC470" modified="2014-04-16" version="1">MSRLLDPSRAAWLYPLRGIYYFASNRFLWPFFKARLVPIVLLSSFIYFILFFFTYLPQVAFLAIFQGSSAWVSGAFLVLGEGAAIVAALFEAFFVDETLVDIFDAVLVNEGQEELVTTSRVIYPEPGNPAKRLGTPTTSAVYSPFSLRQIAEFIILLPLIFIPVAGTPMFLILTGYRAGPLHHWRYFHLLDMSKQQRKETISRRQLQYTTFGTMALILQLIPPFSMLFLMTTAAGSALWATDIERKRRAINQQSSRLGEQYSDDIMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W6QAA9</accession>
    <name>W6QAA9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S02g001254</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QAA9"/>
    <dbReference type="STRING" id="1365484.W6QAA9"/>
    <dbReference type="OMA" id="AMAQTFT"/>
    <dbReference type="OrthoDB" id="5374569at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="269"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM31104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="340" mass="38218" checksum="70A1F75218C18040" modified="2014-04-16" version="1">MPRTLPWLRAENTTPVKKKSTPRKRVKTELADRDLTPKNPRVSPPRRDFFRSSQSPPTSPIRRCPSEEFLIEGIEHDDGWVMVEDEFYAVAQTFTQHLHHAEYLRRRKQVKAEHAAGIREIERPTDGRTSLPNEVERKREAEALRERQKAGLAHIGDGEVEEKDEEDDDDERWAGTHLHDLMTSPRKTRSLAGAHAPKSSTRAAAGFGQAPTLATGRARVNSIGSFTAPSRVSEVISIELDEETASGSDDNDDDDLDLEPRPVLPPPKGTNSTLRKAQAHDQTTLRARQQFEIPSMSTSKPKAKPTHGRPSPANAYKSRVQSLFDDLDELPENLLQDNRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W6QAJ5</accession>
    <name>W6QAJ5_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MARVEL-like domain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S03g000427</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QAJ5"/>
    <dbReference type="STRING" id="1365484.W6QAJ5"/>
    <dbReference type="OMA" id="CFALGIM"/>
    <dbReference type="OrthoDB" id="4918558at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="135"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM33703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="206" mass="23121" checksum="6CAA0E7FFEFC8CF4" modified="2014-04-16" version="1">MIGSVFFIFNRLVEIVFLIPIIGMLAYFVNGYLKANLLTPPYILVLFIVSVIAVFWAIDTLIRFSTTKRSAIFVAFMDLLFVGAFIAAVYELRFITNANCASWHGGSVWISLGPFGSYGQSTNNPLSLDVNKTCAMLKACFALGIMETIFFFWTALLALFLYHSHRPVVKETIVRRRSHSSRRGHGSGSHSRHRSSSRSRPAPYVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W6QAN5</accession>
    <name>W6QAN5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Mss4-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PROQFM164_S02g003247</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfa family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM33096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QAN5"/>
    <dbReference type="STRING" id="1365484.W6QAN5"/>
    <dbReference type="OMA" id="MAEGRCN"/>
    <dbReference type="OrthoDB" id="9985472at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1590.10">
        <property type="entry name" value="glutathione-dependent formaldehyde- activating enzyme (gfa)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006913">
        <property type="entry name" value="CENP-V/GFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337:SF40">
        <property type="entry name" value="CENP-V_GFA DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337">
        <property type="entry name" value="GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04828">
        <property type="entry name" value="GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51891">
        <property type="entry name" value="CENP_V_GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CENP-V/GFA" evidence="5">
        <location>
            <begin position="3"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDM33096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="131" mass="14339" checksum="5E012EF3D671563B" modified="2014-04-16" version="1">MSYHGHCNCESIRVTLPEQPETSAICHCNNCKQAGGGPFSVNYIVNEDDLTVEDPNGALKIYEDKNSDSGNVVKRHFCSSCGSPVFTKTPKAPGVVFLKGPLFDIVSTPALEVFTNKQYDWVNLKQGEIEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W6QAQ6</accession>
    <name>W6QAQ6_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S03</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S03g000269</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QAQ6"/>
    <dbReference type="OrthoDB" id="10553910at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM33545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="109" mass="12271" checksum="0D1E9A644C233B18" modified="2014-04-16" version="1">MVLFESFVWPLTTYLFECFSSKKNSSTSSVKSPIEQSRTTHIKRFINMSSLQCHLDITNEPGSEDETGESVTSEGQVEQEATHLRPWNGFWPRPLTVLKPGGIIPIQGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>W6QAY8</accession>
    <name>W6QAY8_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histone deacetylase</fullName>
            <ecNumber evidence="2">3.5.1.98</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">HDAC1</name>
        <name evidence="12" type="ORF">PROQFM164_S03g000354</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the histone deacetylase family. HD Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.98" evidence="2"/>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QAY8"/>
    <dbReference type="STRING" id="1365484.W6QAY8"/>
    <dbReference type="OMA" id="EHRWDKH"/>
    <dbReference type="OrthoDB" id="1918432at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033698">
        <property type="term" value="C:Rpd3L complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070210">
        <property type="term" value="C:Rpd3L-Expanded complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032221">
        <property type="term" value="C:Rpd3S complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141221">
        <property type="term" value="F:histone deacetylase activity, hydrolytic mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031507">
        <property type="term" value="P:heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10004">
        <property type="entry name" value="RPD3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.20:FF:000001">
        <property type="entry name" value="Histone deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003084">
        <property type="entry name" value="HDAC_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625:SF10">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01271">
        <property type="entry name" value="HISDACETLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone deacetylase" evidence="11">
        <location>
            <begin position="35"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="412"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="416"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="586"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="602"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="613"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="625"/>
            <end position="641"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00061569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDM33630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="641" mass="71307" checksum="3EBA550A0ECCE3D9" modified="2014-04-16" version="1">MALEPISDRLLGSKNKKVAYFYDSDVGNYAYVSGHPMKPHRIRMTHSLVMNYGLYKKMEIYRAKPASKYEMTQFHTDEYIDFLSKVTPDNMDHFVKEQSRYNVGDDCPVFDGLFEFCGISAGGSMEGAARLNRNKCDVAVNWAGGLHHAKKSEASGFCYVNDIVLGILELLRFKQRVLYVDIDVHHGDGVEEAFYTTDRVMTCSFHKYGEYFPGTGELRDIGVGQGKNYAVNFPLRDGITDVTYKSIFEPVIKSVMEWYRPEAVVLQCGGDSLSGDRLGCFNLSMRGHANCVNFVKSFDLPTLVVGGGGYTMRNVARTWAYETGILVGQPLGSELPYNDYYEYFAPDYQLDVRPSNMDNANTREYLDKICNQVVENLKRTAFAPSVQMTDVPRNPIVGGIDDEADDVMDDLDEDENKDKRFTQRRFDQRTEKTGELSDSEDEDENAANGIRRQPGVMRRRNQVNYRNLEPDSGLDSGMATPQDGSSTVDVEMDFGLDTKMANAPRTEPEAPSAALEASHADETPMTDADNMAMESEEHEASTTSQHQSPPPHDEDTTMEDASAVPEATTSEQAPAQASVIEEKSVTEGSTASPVRAQSPTKEATDSTLERTAEASAPTADTEATATKEESLEHKTEPKKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>W6QB54</accession>
    <name>W6QB54_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S02g001519</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QB54"/>
    <dbReference type="OrthoDB" id="2103397at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM31369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="64" mass="7094" checksum="56BAFD35C162524F" modified="2014-04-16" version="1">MTKSIVSISSINSVNSLHLQYEFAIKCKWVLGEKNIIISGIVDYSLWFGQAGNLATNMAMVETK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W6QC06</accession>
    <name>W6QC06_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amine oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S03g000709</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QC06"/>
    <dbReference type="STRING" id="1365484.W6QC06"/>
    <dbReference type="OMA" id="YVTFPRA"/>
    <dbReference type="OrthoDB" id="5046242at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.660.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050281">
        <property type="entry name" value="Flavin_monoamine_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742:SF414">
        <property type="entry name" value="CONTAINING AMINE OXIDASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12150)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742">
        <property type="entry name" value="FLAVIN MONOAMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00419">
        <property type="entry name" value="ADXRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amine oxidase" evidence="1">
        <location>
            <begin position="14"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM33985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="511" mass="56056" checksum="08046C9B5CAD74A1" modified="2014-04-16" version="1">MAPSPHIGIIGAGISGLRCADILIQNGAQVTILEARDRIGGRVHQSTVGDHIVDIGPNWIHGAGENPIMTIAEETGSVMYDPEGGAHISYSRDGHPINDEVSAKVQDFVWTTIAEAFKYSNHHGESIPVEQSLFDFFCDRVQQTKFSDEEKQLCLDACRLWGAYVGDQVDRQSLKFFRLEECVDGSNFIVASTYKRILEHIAETATAKADIRLNEPVTSIKAPPHNNQSPTKHRVTVTTATGTNYNFDDVVITCPLGWLKQNTSAFTPALPPRLEQAINNISYGRLEKVYVTFPRAFWHTQNTSTSTTQTQTQNTVFAQFLEPSYYTHHPAHIEWNQECVSLASFPEPHAHPTLLFYTYGDSGAEIVNRISEQAPSSPEYRESLIDVMQPFYSRLPGYSAENPDCVPVALLATQWQKDVFAGNGSYCNFQVGVEEADVDVEVLRSGDGIGPVRGLWFAGEHTAPFVALGTTTGAFWSGERVARLVCQGLGIGEVGGMGVKDDSLPSAGDVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>W6QCC9</accession>
    <name>W6QCC9_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Coronin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PROQFM164_S03g001052</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM164</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="7">Binds to F-actin.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the WD repeat coronin family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QCC9"/>
    <dbReference type="STRING" id="1365484.W6QCC9"/>
    <dbReference type="OMA" id="NFQDDIY"/>
    <dbReference type="OrthoDB" id="1850764at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000197">
        <property type="entry name" value="Coronin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015505">
        <property type="entry name" value="Coronin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015048">
        <property type="entry name" value="DUF1899"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10856">
        <property type="entry name" value="CORONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10856:SF0">
        <property type="entry name" value="CORONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08953">
        <property type="entry name" value="DUF1899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16300">
        <property type="entry name" value="WD40_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM01166">
        <property type="entry name" value="DUF1899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01167">
        <property type="entry name" value="DUF1900"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8 9" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="DUF1899" evidence="11">
        <location>
            <begin position="4"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="77"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="135"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="184"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="411"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="430"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="486"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="502"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="528"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="547"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="561"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00062568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU280818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDM34328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="615" mass="67217" checksum="6774D0F5DB034C05" modified="2014-04-16" version="1">MSGRFVRSSKYRHVFGRSTRKDQCYDNLRVSRNAWDTNLLKVNPKHIAVNWEAGGGGAFAIIPLEERGKLPERIPLCRGHTAVVLDTDWNPFNDDLIASGSDDGKVFLWRVPENFTVRPEVEADDIQDLAPIGKLSGHPKKIGHVLFNPAAENVLATASGDYTVKIWDIEAGAAKLTLNIGDIVQSQSWSANGSLLVTTSRDKKLRIWDVRQERPAHETNGHTGAKNSRVVWLGERDRIATTGFSKMSDRQLALWDIRAIREPINGFKTLDSISGVCMPFWDDGTNMLFLAGRGDGNIRYFELENDKFEFLSEHKSADPQRGVAFMPKRGVNMHENEVARAYKTVNDQYIEPVSFIVPRRSENFQDDIYPPAAGVSPAMSSSEWLGGKEALPPKISMASLFDGEGIKEVSGVQEKPTGSLDAPAPKPAEAPKAAETPKTAEPTPKPTSSTAVPKPVSEPTPAARSAPSMKEQGASMAAMVNKFADGEEETTVSDDDNSSFEEVAKPVERPTRPAAAESASPRVSSPLRPKEVETKQVEAKQVETKQAETNSQPTLVSSIVPSPASETPSPTTSVPKNDIELIKDLIAEQTKTIASQALQMQTLTAEIEALKSKLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W6QCK6</accession>
    <name>W6QCK6_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alkyltransferase-like protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">atl1</name>
        <name evidence="3" type="ORF">PROQFM164_S03g000939</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QCK6"/>
    <dbReference type="STRING" id="1365484.W6QCK6"/>
    <dbReference type="OMA" id="DEAEWWF"/>
    <dbReference type="OrthoDB" id="2548197at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06445">
        <property type="entry name" value="ATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052520">
        <property type="entry name" value="ATL_DNA_repair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014048">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036217">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNAb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42942">
        <property type="entry name" value="6-O-METHYLGUANINE DNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42942:SF1">
        <property type="entry name" value="ALKYLTRANSFERASE-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01035">
        <property type="entry name" value="DNA_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46767">
        <property type="entry name" value="Methylated DNA-protein cysteine methyltransferase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding" evidence="2">
        <location>
            <begin position="12"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM34215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="136" mass="15160" checksum="D74E65B5D4A27902" modified="2014-04-16" version="1">MPRSEEAEWWANAVYEAIKEIPRGKVTSYGHIARLLGEPQRPRQVGVCLKVLPSPESGSYFNSNTVPWQRVINSKGMISHRGPGSAERQAEALAQEGVEVTTDSMGEMYVDFSRYGWFPSELSSEGTDEQPENNTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W6QDT0</accession>
    <name>W6QDT0_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PROQFM164_S03g001585</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QDT0"/>
    <dbReference type="STRING" id="1365484.W6QDT0"/>
    <dbReference type="OMA" id="HAFSQNA"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF96">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE STCB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDM34858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="203" mass="23136" checksum="771B7EEDACDE062B" modified="2014-04-16" version="1">MELLGILSTSFLISHWLICIIGAALLSTIYRRLTNSLSHIPGPEISKCTDANYTYNWLNGTVPMYIHQLHGKYCPTVRIIPDQIDICDTDAVKETHKTNSQFSKTTFYRKLAIGNEPTVFSTTDRHFHTHRRRLLASPISNSSLARLEPLIANRVRIAVEKITMDIIAHGVTDVFKWWLFMATDIIGELTFGDSFRMLESSHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W6QDT2</accession>
    <name>W6QDT2_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Genomic scaffold, ProqFM164S03</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S03g001375</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QDT2"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM34650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="68" mass="6947" checksum="F1505E0A722489FC" modified="2014-04-16" version="1">MASNIPNTINIVDVLPAPSLPTSTTQSTSSRSASGTSRSASQQVLTQSGFWAVWIVVVGLLGGAGFII</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W6QE55</accession>
    <name>W6QE55_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S02g002635</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QE55"/>
    <dbReference type="STRING" id="1365484.W6QE55"/>
    <dbReference type="OMA" id="SLWDEFT"/>
    <dbReference type="OrthoDB" id="448954at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843:SF2">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="515"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="313"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="335"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM32484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="564" mass="62477" checksum="4938CF0B04B11E7D" modified="2014-04-16" version="1">MESVPNFNRIIHSASFTFLVGPQHTKLTIQSGLAHHVSKPLDHLMNGPTRESKHRIAVLEEDDVETFVAFCEYAYTGNYSVPRPEVQEDHRLGVVESSTITNWRGNYRSDSMSSIVPPPAPSPPPQFRHRRQESYQQSEPSPAYVKEPVTPTFAREPEAESAPDPKTPVSIAEPELETYHEAETAPEPPAEEVPPADDEWAVPTEEPVSWESEEPKAGKKKGKKGKKGKKQAEIVEEEPPAPTEPVSLTPPSTPPPEVAAEPEAEPETEPAEEWSPVNPVPEAESEPAEYWAQPAEEPAPEPAPEPEPEPATEEPAPVEQPTPAAEGPMEDSWTQDRSPGTSVTKAQPQRPMLDMSFAQQKASSSSEPGLNLWDEFISLQYNDEPTASKPTPVESPSTELPYITFHAKLYVFATRYLIPALAQLCLRKLHHDLVLLSPTEFETPHLDDTEILDGLAATKAQMVLELVQYAYTKTARLEPISPTSATQLRENELRRLVVHYLACNVKELSRYHSAEDSVSATPNLRPVDAKTERAETSTSTSPKSLRALLDLTTELASDLVYRMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>W6QEA8</accession>
    <name>W6QEA8_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Elongation factor 1-alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">tef1</name>
        <name evidence="13" type="ORF">PROQFM164_S03g001800</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 11">This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM35073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QEA8"/>
    <dbReference type="STRING" id="1365484.W6QEA8"/>
    <dbReference type="OMA" id="AIRDMGM"/>
    <dbReference type="OrthoDB" id="342024at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01883">
        <property type="entry name" value="EF1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03693">
        <property type="entry name" value="EF1_alpha_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03705">
        <property type="entry name" value="EF1_alpha_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000003">
        <property type="entry name" value="Elongation factor 1-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000005">
        <property type="entry name" value="Elongation factor 1-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000211">
        <property type="entry name" value="Elongation factor 1-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00118_A">
        <property type="entry name" value="EF_Tu_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054696">
        <property type="entry name" value="GTP-eEF1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050100">
        <property type="entry name" value="TRAFAC_GTPase_members"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004539">
        <property type="entry name" value="Transl_elong_EF1A_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00483">
        <property type="entry name" value="EF-1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008969">
        <property type="entry name" value="PRK12317.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23115">
        <property type="entry name" value="TRANSLATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22594">
        <property type="entry name" value="GTP-eEF1A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 11 13" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="10 11" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0488">Methylation</keyword>
    <keyword evidence="7 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="12">
        <location>
            <begin position="6"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDM35073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="460" mass="49943" checksum="E82FE5DA7AEB1D00" modified="2014-04-16" version="1">MGKEERNHINIVVIGHVDSGKSTTTGHMIYKCGGIDQRTIEKFEKEAAELGKGSFKYAWVLDKLKAERERGITIDIALWKFQTAKYEVTVIDAPGHRDFIKNMITGTSQADCAILIIASGTGEFEAGISKDGQTREHALLAFTLGVKQLIVALNKMDTCKWSEERYNEIVKETSNFIKKVGYNPKSVPFVPISGFNGDNMLEPSTNCPWYKGWEKETKAGKSTGKTLIEAIDAIENPVRPSNKPLRLPLQDVYKISGIGTVPVGRVETGIITPGMIVTFAPANVTTEVKSVEMHHQQLKQGNPGDNVGFNVKNVSVKEVRRGNVASDSKNDPAAACDSFNAQVIVLNHPGQVGAGYAPVLDCHTAHIACKFAELLEKIDRRTGKATETSPKFIKSGDAAIVKMVPSKPMCVEAFTDYPPLGRFAVRDMRQTVAVGVIKSVEKNAGGAGKVTKAAAKAGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W6QEH5</accession>
    <name>W6QEH5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S03</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S03g001150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QEH5"/>
    <dbReference type="STRING" id="1365484.W6QEH5"/>
    <dbReference type="OMA" id="WSELYPM"/>
    <dbReference type="OrthoDB" id="3437405at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM34426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="712" mass="80446" checksum="2DEF508A8D697FF7" modified="2014-04-16" version="1">MATRLSRSLPQVNRRVFARLSSRTTPRVANTSARAGLVTRRNARNLAPWACRVTQANIARYSHTDSGESASPNASISNAADYRGSTITEKHWMSQDIVVVDTLIEPQAVLNFMEFITYGILPNGKKTDLALIDSDEFPLFMTPSSEWAPAPFNKAALPTVQKAMMRITGPEDLSGLCYIGQNIHFVKTRLWGGLAPVSASRWREKDLNNPDHFTIAHEYLTSVIAVFEYLNNPQIRTNMRDTFNKISGDFGEIQDALNARRKAQDGFSPELNLTALWEEYIRAQYEVMTSTAHSWVLARVAELRERTLDSLIAIPAEKTESSEMKILAQRWTDLIAVTSMADFNIWMSMDGYNGYTAPSEIIAGLHNPDLEHQDKNYGFSKLLVDRVTKCIEAQNEAAIVQGPSATQSDAARRERLSISTVLQDELREKIRGLAPSPQPPVQPWIQQLLRAQEASLSLQPWERDNYGFGLAIYRTADKFSDEQWATLQRDLEAHLSAWGDDVQGADEIKPHLKLHWFDCKELGFDTANPVTAARRHYQQIRSSEEWNNKIAPSVFLLIDFMGVNSYINDDFYASITKDKTLLKGDFQGFVLAVDPDFDKTVTNESADGTASEDPQDEGLEYPGQVRIMGNLVWSELYPMLNRQSVGLTNLWLQAREHPMKVYTGLTVPSQIQPWKELNAMKTHMMDSFVEFLKKKDPTMAGKVKELRKEGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W6QEU7</accession>
    <name>W6QEU7_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S01g001918</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QEU7"/>
    <dbReference type="STRING" id="1365484.W6QEU7"/>
    <dbReference type="OMA" id="WDIEERR"/>
    <dbReference type="OrthoDB" id="3257538at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019171">
        <property type="term" value="F:(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052741">
        <property type="entry name" value="Mitochondrial_HTD2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28152">
        <property type="entry name" value="HYDROXYACYL-THIOESTER DEHYDRATASE TYPE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28152:SF1">
        <property type="entry name" value="HYDROXYACYL-THIOESTER DEHYDRATASE TYPE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM28107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="353" mass="39680" checksum="BBA1D9433B11D58C" modified="2014-04-16" version="1">MKTNPLRPLVSFRGGRHAYRAYSSLSERLHHELTTRKLPLTYDYLHPQPSHLLNLTLRDLLPQSQGSSDYATLPSLQNPSPLPAGHHLIYFPPQVTLSQLLPDCTDTLHTPGEPFNRRLWAGGNLRFPVRSPPLDGSRAVCIESIRNVTVKGREGDEKVIVTIERRVGNVPEQETADQTWDRVWKENEDDAGESSVIENRDLIFMRLKTSAQIEADKAQFGKPVRTVKPPSDATFRHALIPTKALLFRFSALTFNAHSIHLDKGYTQNQEGYPNLLVHGPLTLTLMLSVLQQQLSRLNLCISTFEYKNIAPLFVEQELVICGKPKNDTGAWDVWIEGPDGGLAVRGTARTRSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W6QF72</accession>
    <name>W6QF72_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S03</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S03g001431</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QF72"/>
    <dbReference type="OrthoDB" id="76567at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM34706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="222" mass="25468" checksum="D586C9C5A4DBD5CE" modified="2014-04-16" version="1">MLYEDVLPSTTPTYEYKGIQDSLQILDRELEDSSNPYIVFIIDERSFLDCFENSEEGLLRTSWDTYDPSSNRLVVRMQTIIHSSASGSFASIFSSWPKDDNYRLIPMTKASVRGQSGMNKQADYSWTPIQSGRLKEFPTMVVEIAWSETRTKLVEDMNFWLSQCYGEVRTALSITVHARGKITIEKWELQGATPIPSHPENGDRTKTRTKMREDPRAPPPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W6QFF5</accession>
    <name>W6QFF5_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Serine/threonine-protein kinase SSN3</fullName>
            <ecNumber evidence="6">2.7.11.22</ecNumber>
            <ecNumber evidence="5">2.7.11.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="21">Cyclin-dependent kinase 8</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">Serine/threonine-protein kinase ssn3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="27" type="primary">ssn3</name>
        <name evidence="27" type="ORF">PROQFM164_S01g002123</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="27" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10216"/>
            <dbReference type="Rhea" id="RHEA-COMP:11321"/>
            <dbReference type="Rhea" id="RHEA-COMP:11322"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43176"/>
            <dbReference type="ChEBI" id="CHEBI:68546"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the SRB8-11 complex, a regulatory module of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="6"/>
    <dbReference type="EC" id="2.7.11.23" evidence="5"/>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QFF5"/>
    <dbReference type="STRING" id="1365484.W6QFF5"/>
    <dbReference type="OMA" id="YFKNGGP"/>
    <dbReference type="OrthoDB" id="6284126at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008353">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07842">
        <property type="entry name" value="STKc_CDK8_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000408">
        <property type="entry name" value="Serine/threonine-protein kinase SSN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000426">
        <property type="entry name" value="Serine/threonine-protein kinase ssn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF495">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0010">Activator</keyword>
    <keyword evidence="13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12 27" id="KW-0418">Kinase</keyword>
    <keyword evidence="14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-0539">Nucleus</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0678">Repressor</keyword>
    <keyword evidence="8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="17" id="KW-0804">Transcription</keyword>
    <keyword evidence="15" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="26">
        <location>
            <begin position="51"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="399"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="25">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="25">
        <location>
            <begin position="399"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00039418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00040708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00041823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00049280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="EMBL" id="CDM28312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="437" mass="49043" checksum="0C09295FB65FD66C" modified="2014-04-16" version="1">MSLTNPPSSSGSLSRTRVGNLKRSHQATVDDAIESRRPGGYTSKVRVRDRYNIVGFISSGTYGRVYKAVGKNGKKGEFAIKKFKPDKEGETIQYTGLSQSAIREMALCTELSHANVVQLEEIILEDKCIFMVFEYTEHDLLQIIHHHTQPQRHAIPATMVRSIMFQLLNGLLYLHTNWVLHRDLKPANILVTSSGAIRIGDLGLARLFYKPLNSLFSGDKVVVTIWYRAPELLMGSRHYTPAVDMWAIGCIFAELLSLRPIFKGEEAKMDSKKTVPFQRNQMMKIVEILGLPRKESWPGLASMPEYSQLQTLVLHRQPSHFHRGSNLEGWYQSCLKNGGYTSTSSAGTPGADGFDLLSRMLEYDPAKRLTAEQALEHPYFTNGGPISGNCFEGIEGKYPHRRVTQDDNDIRTGSLPGTKRSGLPDDSLMRASKRLKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W6QFI8</accession>
    <name>W6QFI8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S02g003085</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QFI8"/>
    <dbReference type="STRING" id="1365484.W6QFI8"/>
    <dbReference type="OrthoDB" id="4185642at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM32934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="62" mass="7023" checksum="83C134ACF942EE03" modified="2014-04-16" version="1">MLLVRGNLDRMVWIDFGIATTFTNFGPEQLAYCQHEIALIEGLGELLREDQAEGLPPNTKLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W6QFK9</accession>
    <name>W6QFK9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g002213</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QFK9"/>
    <dbReference type="OMA" id="IRSRDRW"/>
    <dbReference type="OrthoDB" id="4362041at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM28402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="263" mass="29664" checksum="0F75926AD8F9EC9C" modified="2014-04-16" version="1">MGGDTGTFIKARVVFTIVYRALPPLPLPWKRRTSLKGKSPELEIHIDEKNPGSSDSDISPHAEDQHNGTVFMHRDVHGPVQVAVKTHAHHNAPTPQSLSSTPDNIPGPASGPASECRVHYSSQARPTRAQLDRAVSWASIIRSRDRWTAEQERELVHAKRQLGRCQKAWSSEQEVWLTYVQALSEEKEAHNGFLSMRHRQQDDEQHQFRKAWKRRRSSSGDDEVQQSAIETANRLGRLRRLQRYSYSGQRLGATGSTVLAVEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W6QG12</accession>
    <name>W6QG12_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ribosome biogenesis protein BMS1/TSR1, C-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PROQFM164_S04g000221</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TRAFAC class translation factor GTPase superfamily. Bms1-like GTPase family. TSR1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QG12"/>
    <dbReference type="STRING" id="1365484.W6QG12"/>
    <dbReference type="OMA" id="MNLPRFK"/>
    <dbReference type="OrthoDB" id="119302at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000479">
        <property type="term" value="P:endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012948">
        <property type="entry name" value="AARP2CN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039761">
        <property type="entry name" value="Bms1/Tsr1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007034">
        <property type="entry name" value="BMS1_TSR1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030387">
        <property type="entry name" value="G_Bms1/Tsr1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12858:SF1">
        <property type="entry name" value="PRE-RRNA-PROCESSING PROTEIN TSR1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12858">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08142">
        <property type="entry name" value="AARP2CN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04950">
        <property type="entry name" value="RIBIOP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22298">
        <property type="entry name" value="Tsr1_G-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00785">
        <property type="entry name" value="AARP2CN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01362">
        <property type="entry name" value="DUF663"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51714">
        <property type="entry name" value="G_BMS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Bms1-type G" evidence="6">
        <location>
            <begin position="88"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="408"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="30"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="408"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM35340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="806" mass="90435" checksum="BD6B9BDB5DC29EDB" modified="2014-04-16" version="1">MAPAQTVHHHRSTTKVSHKPYKTKHASKSALKDQAKGKIEGDERGGRRTPHQQLKTKLDRRNTARQRQALKHQERSQATSVFAGQNGAPRHVAIVPLSADVDAAAAIASINESVDVLTDVSPDGPTRVRIDRFRQSVQYVPAKYDLMSALDVCRMADFVILVMSSEVEVDEEGEMLLRSIQGQGISNVLAVVQGLDKIEPPKKRPQVATTLKSFINHFFPSIEKVMSLDSRQESSNAIRSICTATPKGIRWRDDRSWMFVENVQWPESNQEVVDDVVITGVVRGRGLKADRIVHVPGWGDFQIDSITAAPLTTTKPKRDDAMAVDADETTQILDTPTEDQDDMATIAPEEIEMVDDDMVSMAETEKKGVLLDDYHYFSDDDSHIPPVPKKLPKGTSNYQSAWYLDDVSDSGSDMEDEDEPMEMDTAGAPEDGVFPDHQDAMTEGGGTEYPQSEMFLDPSPEDEAQELADYRASRKTEAEEDLEFPDEIELHPNALARERLARFRGLKNLKLSHWETSEDRPYEPEDWRRLLQFADVKGSKNRIIREALAGGVNPGVRVDIHLRAVPSILRNSPKPISLFSLLRHEHKQTVVNVSMTLNSSVEKPLKAKEQLVIQCGARRMVVNPIFSSADNTPNNVHKYDRYLHPGRSAIASWIGPMTWGSVPILVFKQKKSEQEDADDEMETADSKEEPIALDQLELIGTGTVVAPDQKRVVAKRAILTGHPYKIHKKVVTIRYMFFNAEDIQWFKALQLWTRRGRSGYFKESLGTHGYFKATFDAKINPQDSVGVSLYKRVFPRKSKALDAITA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W6QG21</accession>
    <name>W6QG21_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">MICOS complex subunit MIC10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PROQFM164_S01g002413</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Mitochondrion inner membrane</location>
            <topology evidence="2 9">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the MICOS complex subunit Mic10 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QG21"/>
    <dbReference type="STRING" id="1365484.W6QG21"/>
    <dbReference type="OMA" id="SNCRHDL"/>
    <dbReference type="OrthoDB" id="1916310at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061617">
        <property type="term" value="C:MICOS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007512">
        <property type="entry name" value="Mic10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21304">
        <property type="entry name" value="MICOS COMPLEX SUBUNIT MIC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21304:SF0">
        <property type="entry name" value="MICOS COMPLEX SUBUNIT MIC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04418">
        <property type="entry name" value="DUF543"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="29"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDM28602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="91" mass="9949" checksum="BFA41FC3FA78FC14" modified="2014-04-16" version="1">MAESSESGPIARATKPVSEALLNEKWDRAISSVIIKSSLGLSFGVVFSVLLFKRKAWPAWIGLGFGAGRAWEEADASFRRGDSPIRDALRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W6QGU6</accession>
    <name>W6QGU6_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S04</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S04g000541</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QGU6"/>
    <dbReference type="OMA" id="ERPIMAP"/>
    <dbReference type="OrthoDB" id="5399555at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM35660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="117" mass="13012" checksum="C4BA4A625BA88A9D" modified="2014-04-16" version="1">MARQPSLDSERPIMAQSNRNSKRFSTVSGSPSLAASDSTTLNGDPRIADIYHLHDGFGRLESKPLNKQRFVPTEEKSDNLNKLALGAKVERALGRRMTSQDAVMRKPLSEKTEVRTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W6QI40</accession>
    <name>W6QI40_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S05g000311</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QI40"/>
    <dbReference type="STRING" id="1365484.W6QI40"/>
    <dbReference type="OMA" id="NMTIIIR"/>
    <dbReference type="OrthoDB" id="4352890at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="356"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="143"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="168"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="379"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="413"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="433"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM36478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="566" mass="62547" checksum="4834183E477CE53A" modified="2014-04-16" version="1">MPPQPQPLSRWPHNFDDKYVFKRLDILYSPTDQQLLHDLAQEVYDIVALDALNNGRVLVNVFRSSASRDKMLIEWRKRLPRLPAATLAHVTDHTLLCGALYKYLNCIQDELQTEFDRRQNPLAEQTGGEKTAAQPVQRGVSKSVQHSIEVSEQQVEEQLEGELAHQLAQQSSPQPEQPPAEQQPQQPARSAQRNPDRQNKFDYGRPYIVPNGDVQIIRADHPDMPLAMRVSDFLTDKVNPQDTCPDGDWINIANIQFELFKQNLTREGYLRDRETIWLSHLSLDQIDPANVANPQIGEVRMAALNFASTIVRTIREYWPRLRNPSPDPFRGDRRSPLPRPNMTIIIRTGVIKGGALTPKQPALARPTEKMGSNAIAHNRRSEQVARYAAERHAKTKRKRAEAEAEAGAGAGAGANTEAETGAENEAATNAPVTRKRRITRTRKTAVTSATGTDSARESDDDIDSAGPEFSDTNYSPAPTRAPVPLPTLALAPAPVPAAVPVPVSAPAGEQLLGDVGDPMLGVLDTEMFNEEGLVGDSDGALQAFFEGNHWVGDPMDGVERSNEGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W6QIK4</accession>
    <name>W6QIK4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha-methylacyl-CoA racemase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">Amacr</name>
        <name evidence="2" type="ORF">PROQFM164_S04g000707</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CoA-transferase III family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QIK4"/>
    <dbReference type="STRING" id="1365484.W6QIK4"/>
    <dbReference type="OMA" id="VVIDPFR"/>
    <dbReference type="OrthoDB" id="16747at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="entry name" value="Crotonobetainyl-coa:carnitine coa-transferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.10">
        <property type="entry name" value="formyl-coa transferase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050509">
        <property type="entry name" value="CoA-transferase_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044855">
        <property type="entry name" value="CoA-Trfase_III_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48228:SF5">
        <property type="entry name" value="ALPHA-METHYLACYL-COA RACEMASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48228">
        <property type="entry name" value="SUCCINYL-COA--D-CITRAMALATE COA-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="CoA-transferase family III (CaiB/BaiF)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM35826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="382" mass="41659" checksum="5D74E5344B2CF236" modified="2014-04-16" version="1">MLPLKGIKVIELAGLAPGPFAGLLLADYGASVLRIDRPNSTSVDQLTRDQLTRNKTSITLDLRNQNSLNILLRLLPTADILIDPFRPGVLERLGLSPTEVLQKHNPRLIVARMTGFRRDGKYKDMAGHDINYIAVSGVLSTLGRAGEKPHAPGNILGDFAGGGAVCFQGILLALISRSHTGRGQVVEANMVDGSAYLATFPRLARKTPAWAQPRGENLLDGGCPYYDTYETKDAGRYFAVGALEPQFYAALVRGLGFEIGELPEREDRTQWPVLREIFTRRFKEKTRVEWEAVFDGTDACATPVLEQAELEEGGYEQRPMVHLVSTPGKPISADNGGWSGGGLLPGDGGVDTLREWAGWEQGKDFEVRKDGAFVAMDGKSKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W6QIU9</accession>
    <name>W6QIU9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S05g000158</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QIU9"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM36325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="68" mass="7748" checksum="75D5268498406504" modified="2014-04-16" version="1">MELELENGYGHRWGKDGLDSGWMWVFGATGLPTAWLVCMRPYTAWDEMDGKLEIGNWDGAVRSARSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>W6QJ89</accession>
    <name>W6QJ89_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PROQFM164_S04g000967</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM36086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QJ89"/>
    <dbReference type="STRING" id="1365484.W6QJ89"/>
    <dbReference type="OMA" id="HVQHTIY"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00302">
        <property type="entry name" value="cytochrome_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000090">
        <property type="entry name" value="Cytochrome P450 monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF218">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="492"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM36086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="556" mass="62742" checksum="1F83C930F2BF7750" modified="2014-04-16" version="1">MASRSFFLIGDDPSTAQSIEVAQELDLNGLKSVVARSFHIIQPAGVSFHVSNNPISKIGEVLDSNEPIGIRIGNHGVREPSGPKGLPLVGSFYEIFPDHLGNHFRLFRKYGGLIKTTNMGKTNYLTDDPEIAAIVLNESLHFTKRITDDHPLRGVKDNIATFVSDTETETWRLTHKYLPTSMGPKAVRHYAPLMQETVRRSFAVFDTFSENMQSWNVYQYMTKLASETVGKVILGEEFGHLAEIDAPFHPIVMSILNMFALNKKVASRGSWYRNLPFGDPRKLRESHRLCYTLVEEIVAKIEKSDGAMQKMPMANAALNASSLVEYLINATDEKGETFPRSMIVPNISMLTSAGFATTASLLSWLIFCLTTYECNQDRLLQELVDMGVTPSTDWNVDLVNKLLFLDKFVKETLRLHNPAFQPARTTKTEVILPGGYRLEPDSVVVCALYDLHSNPEHWSDPTQFQPDRWDTDKVKSRHRAAFLPFAMGGRGCIGFNFALLEAKILFSELVYRYEFALDDEDKVQYDPEFQLVRPLNLYVSVKKRTSWPEGSLNGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W6QK19</accession>
    <name>W6QK19_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S02g000071</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM29922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QK19"/>
    <dbReference type="STRING" id="1365484.W6QK19"/>
    <dbReference type="OrthoDB" id="9997739at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM29922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="234" mass="26453" checksum="B5EE3F1189579B6C" modified="2014-04-16" version="1">MIQVRPDQFISPLAYLEVGPNGKKFAAPSGIIQSLRCRYKSSPEIIYVVDDDVEDIFGHILQYLHSGDYSVLIPAADKSSHASCEDEIDIATQDLLPLKENYFASHEDIQVKTDNSISLPHCGDGNHLCKHPKTLLVHARLYDFATRHGLDQLGNVSFNKLYWTLSEYPLDSEQADAIVELLRVANGIGTIYALMIHYVSFHLKTFIRCSSFLSFLEENHHISFHLFNLLCDSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W6QK80</accession>
    <name>W6QK80_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S03</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S03g001358</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QK80"/>
    <dbReference type="OMA" id="FWMGSQD"/>
    <dbReference type="OrthoDB" id="73788at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="553"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="639"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="314"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="342"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="365"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="384"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="410"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="427"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="439"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="467"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="579"/>
            <end position="588"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM34634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="659" mass="73300" checksum="DB9D6E1586848B47" modified="2014-04-16" version="1">MKEPPPEARNLPETPRNQFRTPRSHSPQGLPTTATKTKTARNRPPQSSTSASIRKRTSLPRVQSTLTQIDFVTQSTPSNDDQLSYIDEHKRRDDTHDTTERPNVDDESDKESDYLPAPPLRSARISKFRMSEREHDSDERPQKRRSSGFASRDTHRSDGPRKSEAPRASIRPRGGRKSLEKSAGKRDKTLTQMDFVRRYITINDDDDDVNMGYIQPTPQKKGMKDEPTEHTPKLNQPQTTKRPTSTKRNRRALEEELDLSTGEPISQQNEAQQSNPGSEGEGERVSAAPVTPRKLRAREIPSSQTPESPGLAIITSSQFRSATRSPSKRNPLSPTDNSTYPVKEETTEARRVVGDSQDPGGESLPQPTTFNSPGIYNHLIHPDLTTTEEFPSSAPPTESTSQEFPTEEIGDSRNEPTKRERTVIYETDADSEYGDSEDNLNGSSVTPSSKKANRPIGPQDGVQGTEHSAELSKDDSQELPLPVVQSSPGPNDPPSEGPMSDASICYRRMHVATQFPHEPIPMLNTQKMAELFPHGDSTQYTNLEAWRPSLRKQATGPLLQTQSQEGDKESTEMVPESSPIREQERGIDSGDSSFQRPRVPGSVVQVESSQAVDRDPQWQGRVLSRSQLLTSSVMESIPLPNFWMGSQDSVGEPYSLPEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W6QKH9</accession>
    <name>W6QKH9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cobalamin (Vitamin B12) biosynthesis CobW</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PROQFM164_S06g000264</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the SIMIBI class G3E GTPase family. ZNG1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG792020">
        <property type="protein sequence ID" value="CDM37303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QKH9"/>
    <dbReference type="STRING" id="1365484.W6QKH9"/>
    <dbReference type="OMA" id="GHSHMDP"/>
    <dbReference type="OrthoDB" id="258627at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03112">
        <property type="entry name" value="CobW-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1220.10">
        <property type="entry name" value="CobW-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036627">
        <property type="entry name" value="CobW-likC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011629">
        <property type="entry name" value="CobW-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003495">
        <property type="entry name" value="CobW/HypB/UreG_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051316">
        <property type="entry name" value="Zinc-reg_GTPase_activator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13748">
        <property type="entry name" value="COBW-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13748:SF31">
        <property type="entry name" value="ZINC-REGULATED GTPASE METALLOPROTEIN ACTIVATOR 1A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02492">
        <property type="entry name" value="cobW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07683">
        <property type="entry name" value="CobW_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90002">
        <property type="entry name" value="Hypothetical protein YjiA, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CobW/HypB/UreG nucleotide-binding" evidence="9">
        <location>
            <begin position="36"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="CobW C-terminal" evidence="10">
        <location>
            <begin position="326"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDM37303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="397" mass="43439" checksum="0F2C2BEA2D328500" modified="2014-04-16" version="1">MSANFEDEDAPPELIDVSATPADQTSVDEEPTARVPITLITGYLGAGKTTLLNYILTEKHGKKIAVIMNEFGDSMDIEKPMTVNQGGQEVTEWMEVGNGCICCSVKDSGVMAIESLMERRGTFDYILLETTGLADPGNIAPIFWMDEGLGSSIYLDGIVTLVDAKNIMRLLDEPAPEEKAESHDVHHDHGSGPVLSMAHMQISHADVVILNKTDLVTDEELEAVRDRVASINSVAKIHVTDHSRTPQIEGVVLDLHAYDHLADLDFSKKGHSHMDPAISTIAIVTPPIPADKVNCVDAWLRSVLWDTTFPAPAKSVSSEPHPVDFEVHRLKGILILDNGKSRIIQAVRDVFEIRDAEPIDTEDKSKPLQCKIVLIGRGLGPSAEPWRESFESCLVAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W6QLC8</accession>
    <name>W6QLC8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S05g000609</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QLC8"/>
    <dbReference type="STRING" id="1365484.W6QLC8"/>
    <dbReference type="OrthoDB" id="4485682at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021842">
        <property type="entry name" value="DUF3435"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11917">
        <property type="entry name" value="DUF3435"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM36776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="57" mass="6374" checksum="668F920B08158FE4" modified="2014-04-16" version="1">MYVEDVAEFARVILFTIEMTFPSWYRIQLPLFCQLAASTGSRSGALQLRASAASPVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W6QLD6</accession>
    <name>W6QLD6_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S02g000516</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QLD6"/>
    <dbReference type="STRING" id="1365484.W6QLD6"/>
    <dbReference type="OrthoDB" id="4364054at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM30367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="111" mass="12100" checksum="7B86727F12666207" modified="2014-04-16" version="1">MDITWSQLGHSFHGQQELKMQATEKPTQSGIDLTLPEEKTQDAGGATRQLGTGLSTVMGFLTNFHVVDDGSGYRRRINRASIWGLSLDGHDSPFDVIVMPPGCEKVVPKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W6QLI5</accession>
    <name>W6QLI5_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type DNA-binding domain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PROQFM164_S05g000669</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QLI5"/>
    <dbReference type="STRING" id="1365484.W6QLI5"/>
    <dbReference type="OMA" id="LWHILEW"/>
    <dbReference type="OrthoDB" id="5226580at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF37">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDM36836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="627" mass="71310" checksum="9BE06CA1E96B9047" modified="2014-04-16" version="1">MESMSGHIKTCQNCARGKIRCIRTSDSSICDRQLRCRRLGKECYFRPARPRYNPAKKGTRVEALEAKVDQLLAQVVNNQHTKHQADVPLVLPDPEPHSIPDKPRDVIDRGIVRFDDAVTILESFRETLMPFFPFIYIAPEVTLAQLRAEKPLLLLAILKVSSYKNAASQQILEETFQKAVADQMIFAHNPSMDLLLGLLVALAWLQHQSQHERFCSYINLAWSIVGDLRLDRLSEIHSYYSRMAMSKVSSDENSSRHSVNERRRALIGCYMLSSCHSTMLQKDRMMTRLSYVEKHALGLLSNAEIASDRCLVQLVKLQQIFERIDDAVATTANPVREVDMHAFQIEINEYRTTLSATPSDNSLFQFQLHTLQLFLCQACLFEKHETANYSASPAPRSHADPGLPPHLKSGHQPLDLSPFQVEFLNRGMTEAKKFFDYFFTLAPKTHRLISHIQWLQSGFNLVLGCKLAIMGAKYAPRSPHVRALCSDLNMPHILRTVLQLIQWLSKDRVAVDGKQHSKYFYEAWLWHILEWFEQKYHLVPSEDTAQIPIGLSDGGFGPSTLANSAISQDVSLMGETYGATQVAQVDDTDLWPDFLWNISTDDILNGYMGLPDMLYPTLQSAYDMPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W6QM30</accession>
    <name>W6QM30_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">GTP binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S07g000242</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792021">
        <property type="protein sequence ID" value="CDM37893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QM30"/>
    <dbReference type="STRING" id="1365484.W6QM30"/>
    <dbReference type="OMA" id="GWLNNKP"/>
    <dbReference type="OrthoDB" id="1696305at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050896">
        <property type="entry name" value="Mito_lipid_metab_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46434">
        <property type="entry name" value="GENETIC INTERACTOR OF PROHIBITINS 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46434:SF1">
        <property type="entry name" value="GENETIC INTERACTOR OF PROHIBITINS 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM37893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="652" mass="73271" checksum="7BF090AFA6F09F20" modified="2014-04-16" version="1">MSLCSRGAVFRNPRFSLLCLLPKSIPRSQAQIPFSKSRAAPQSKGLADLRRQCRCFSTTRLQREQPLAEPQAGTLADSLPLCCPGCGAFSQTVEANEPGYYGTSRKQIRKLLAVRKEAIEYRNKQQNEVISTEGGSLSAQQSDAIEDAVPPKPIQGRTSRQLRKVAILLTEEKDGAFPDEAVDPENNFLGSPGRITEVCDRCHDLIHHNKAVSSPKPTILSIRNYLEESPYRHNRVYHIIDAADFPMSLVPRIHWALMLQEQRSRNRRSTNEKFERGRRLPSLSFIITRSDLLAATKEQVDSKMDYIRTELRAALGRSGKEARLGNVHMISAHRGWWTKEVKEEIREHGGGIWVVGKANVGKSSFIEACFPKDSRNVEKIEEWVQRREENEIPTFLNPDSLLPPAPREDLYPVLPVVSSLPGTTVSPIRIPFGRGKGEVIDLPGLERGLLEDFVRDEYKRDLIMTKRIKPERSTIKPGQSLLLGGGLIRITAVNPQDTVMSASFLPLESHITNTQKAIDTQAEEIPYRGTVIMKEGTGSTIASAGIFDLKWDTTTSNLPTSLAKAVKDRGIPVPSLPYRVMSADILIEGCGWIELSIQIRSKRDTEDEPSYPQVEVFTPNGKHIGCRRPIECWNFIAEKKKIDKRKQPRTRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W6QM62</accession>
    <name>W6QM62_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Amidohydrolase 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PROQFM164_S02g000812</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-dependent hydrolases superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QM62"/>
    <dbReference type="STRING" id="1365484.W6QM62"/>
    <dbReference type="OMA" id="RIESCIM"/>
    <dbReference type="OrthoDB" id="191270at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000055">
        <property type="entry name" value="Uracil-5-carboxylate decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032465">
        <property type="entry name" value="ACMSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240">
        <property type="entry name" value="2-AMINO-3-CARBOXYLMUCONATE-6-SEMIALDEHYDE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240:SF28">
        <property type="entry name" value="ISO-OROTATE DECARBOXYLASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="4">
        <location>
            <begin position="8"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU366045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDM30662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="383" mass="41928" checksum="E2E9E2C8CBD9CF10" modified="2014-04-16" version="1">MSRPLVVDVHTHVYPPSYMAMLRARKTVPYIHDPASGEPRLIILSSDDDPSIPIDERGRPVDTSYSDINVKLTFMQQHGIDCSVISLANPWLDFLDPAEAQQWAERINNDLEETCAQNNKSTDPDNTLPLQGRSTLFAFATLPLSAPSADIIVNEIKRLKTLPHIRGVIMGTSGLGNGLDDEALGPVWAALEETQFLLFLHPHYGLPDEAFGGPEVTKRYGHVLPLALGFPLETTIAVTRMLLSRVFDKFPRLQILLAHSGGTLPFLAGRIESCIMHERKFVENGGDVPGPQRSIWEVLKTNIFLDAVVYGAAGLKAAVAAGGGTDRLMFGTDHPFFPPLNEGEKEWISVTTNYKAIDATFEGEKEAVAAVLGGNAVRVLKLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W6QME9</accession>
    <name>W6QME9_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PROQFM164_S08g000099</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792022">
        <property type="protein sequence ID" value="CDM38048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QME9"/>
    <dbReference type="OMA" id="CACIPVL"/>
    <dbReference type="OrthoDB" id="4682787at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF93">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="85"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="163"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="202"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="28"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="305"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="324"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM38048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="380" mass="41834" checksum="5C4DB948FEA5AA44" modified="2014-04-16" version="1">MPALRGKGPTLVGVLWFETTLCMLVLALRVYTRTVIRRNTGWDDLLLLASWILMVAFTALCTAAAHYGMGVHSGELSVDQTTHGMLLLLAGQSIIAISMGLSKCAVAAFLMRIVVKKWHKLFLWFWIVSIMVLSIILAVTVFAQCTPVESIWDPRIPSKGCSLNLAVMATIMCAWSAVLDFVLALFPWLALWNLNMKKKEKYTICFSLSLGIFAGICGIIRTTGLNALTQSSDYLYATTDSVIWTMSELSTTILCVSIPALRPLWRSICGDISSNDASNYTDLPPYGKSSAGRSVKQPTFAMDTVTTTTVHGKDLDDESGSSGRNEEHGEDTDTRHILPHPRPHSTGIYQVNEVTISYEDRRPGDGDSIPSDPVKTRQHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>W6QMH1</accession>
    <name>W6QMH1_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">prp43</name>
        <name evidence="16" type="ORF">PROQFM164_S02g000902</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Pre-mRNA processing factor involved in disassembly of spliceosomes after the release of mature mRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DEAD box helicase family. DEAH subfamily. DDX15/PRP43 sub-subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QMH1"/>
    <dbReference type="STRING" id="1365484.W6QMH1"/>
    <dbReference type="OMA" id="MKVYPLY"/>
    <dbReference type="OrthoDB" id="10253254at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000390">
        <property type="term" value="P:spliceosomal complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17973">
        <property type="entry name" value="DEXHc_DHX15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000007">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000324">
        <property type="entry name" value="pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000003">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044756">
        <property type="entry name" value="DHX15_DEXHc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF109">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX15 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 16" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="14">
        <location>
            <begin position="98"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="15">
        <location>
            <begin position="288"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00055599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CDM30752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="756" mass="85389" checksum="833309360485375D" modified="2014-04-16" version="1">MADNRSDSEGGARAKRQKMDAGDPKNNPYLAHMYENNNGSDNTALAKFKRHQTTAAMAKKAEDGDINPFSGRPFSSKYFSILKTRRDLPVHTQRDEFLQLYQQSQILVFVGETGSGKTTQIPQFVLYDDLPQTQGKMIACTQPRRVAAMSVAQRVAAEMDVKLGEEVGYSIRFEDMTGPKTIMKYMTDGMLLREAMNDPNMSRYSTIILDEAHERTMATDILMGLLKEVVVRRPDLKIIIMSATLDAQKFQRYFMDAPLLAVPGRTHPVEIFYTPEPEQDYVEAAVRTVLQIHATEGEGDILLFLTGEEEIEDASRKIALEGDEMVREADAGPIKVYPLYGSLPPHMQQRIFDPAPPPRRPGGRPGRKVIVSTNIAETSLTIDGIVYVVDPGFSKQKIYNPRIRVESLLVSPISKASAQQRAGRAGRTRPGKCFRLYTEGAFKKELIESTYPEILRSNLSSTVLELKKLGVDDLVHFDLMDPPAPETLMRALEELNYLACLDDDGNLTQLGRLASDFPLDPALAVMLISSPEFYCSNEILSITALLSVPQVFVRPPAQRKRADEMKNLFAHPDGDHLTMLNVYHAYRSSDAQANPKQWCHDHFLSQRALQSADNVRSQLLRIMERQDLEMISTAFDDKKYYENIRRALCAGFFMQVAKKDTGGKSQYLTIKDNQNVLLHPSTVLAHEAEWVLYNEFVLTTKNYIRTVTAVKPEWLLDIAPTYYDINSFPKGDIRSALTRAADRLARKEKMRAEKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>W6QN07</accession>
    <name>W6QN07_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="10 12">Adenylosuccinate synthetase</fullName>
            <shortName evidence="10">AMPSase</shortName>
            <shortName evidence="10">AdSS</shortName>
            <ecNumber evidence="10 12">6.3.4.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">IMP--aspartate ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PROQFM164_S10g000072</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.</text>
    </comment>
    <comment type="function">
        <text evidence="12">Plays an important role in the de novo pathway of purine nucleotide biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 12">
            <text>IMP + L-aspartate + GTP = N(6)-(1,2-dicarboxyethyl)-AMP + GDP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:15753"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57567"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="6.3.4.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="10">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="10 12">Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 10">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10 12">Belongs to the adenylosuccinate synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.4" evidence="10 12"/>
    <dbReference type="EMBL" id="HG792024">
        <property type="protein sequence ID" value="CDM38258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QN07"/>
    <dbReference type="STRING" id="1365484.W6QN07"/>
    <dbReference type="OMA" id="FHHAKPI"/>
    <dbReference type="OrthoDB" id="10265645at2759"/>
    <dbReference type="UniPathway" id="UPA00075">
        <property type="reaction ID" value="UER00335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004019">
        <property type="term" value="F:adenylosuccinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044208">
        <property type="term" value="P:'de novo' AMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046040">
        <property type="term" value="P:IMP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03108">
        <property type="entry name" value="AdSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.300.10:FF:000001">
        <property type="entry name" value="Adenylosuccinate synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.170.10:FF:000001">
        <property type="entry name" value="Adenylosuccinate synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.440.10">
        <property type="entry name" value="Adenylosuccinate Synthetase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.300.10">
        <property type="entry name" value="Adenylosuccinate Synthetase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.170.10">
        <property type="entry name" value="Adenylosuccinate Synthetase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00011">
        <property type="entry name" value="Adenylosucc_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018220">
        <property type="entry name" value="Adenylosuccin_syn_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033128">
        <property type="entry name" value="Adenylosuccin_syn_Lys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042109">
        <property type="entry name" value="Adenylosuccinate_synth_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042110">
        <property type="entry name" value="Adenylosuccinate_synth_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042111">
        <property type="entry name" value="Adenylosuccinate_synth_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001114">
        <property type="entry name" value="Adenylosuccinate_synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002223">
        <property type="entry name" value="PRK01117.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00184">
        <property type="entry name" value="purA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11846">
        <property type="entry name" value="ADENYLOSUCCINATE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11846:SF0">
        <property type="entry name" value="ADENYLOSUCCINATE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00709">
        <property type="entry name" value="Adenylsucc_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00788">
        <property type="entry name" value="Adenylsucc_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01266">
        <property type="entry name" value="ADENYLOSUCCIN_SYN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00513">
        <property type="entry name" value="ADENYLOSUCCIN_SYN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 10 12" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 10 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="8 10 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 10 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 10 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 10 12" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="12"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="40"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="140"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="11"/>
            <end position="17"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="12"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="37"/>
            <end position="40"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="39"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="294"/>
            <end position="300"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="298"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="300"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="326"/>
            <end position="328"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="411"/>
            <end position="413"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDM38258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="423" mass="46395" checksum="5D2F1294CBCB505C" modified="2014-04-16" version="1">MVSIVLGSQWGDEGKGKITDMLSQTATLCCRAAGGHNAGHTIVHEDVTYDFHILPSGLVSPKCINLIGAGTVFHVPSFFKELAAIEAKGLKGAAQRIFVSDRAHVCFDLHSVVDGLEEKGLGGRKVGTTGKGIGPCYSDKAARRGVRVGEILDEATFERKLRTLDMSYRTRFGDLAYDVEEEIARFREYRTLLKPYIVDQLEFLQAHKDSTNTLVEGANALMLDLDHGTYPYVTSSSTGLGGAVQALALNPTSIKSVIGVVKAYTTRVGSGPFPSEQLNEDGDKLQKVGREFGVTTGRRRRCGWLDLVLCRYSHAINHYTALNLTKLDILDDFDEIKVGVAYILPDGKRTTGTFPADPNVVDKIQVEYVTLPGWKSNTMGVQRYEDLPPNARAYIEFIEREIGGVPVKWIGTGPARSHMITRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W6QN51</accession>
    <name>W6QN51_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Alpha/beta hydrolase fold-3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PROQFM164_S02g001227</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 'GDXG' lipolytic enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QN51"/>
    <dbReference type="STRING" id="1365484.W6QN51"/>
    <dbReference type="OMA" id="SEGCPHD"/>
    <dbReference type="OrthoDB" id="2152029at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033140">
        <property type="entry name" value="Lipase_GDXG_put_SER_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF8">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01174">
        <property type="entry name" value="LIPASE_GDXG_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="4">
        <location>
            <begin position="114"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDM31077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="377" mass="42765" checksum="26E52A9759984CDA" modified="2014-04-16" version="1">MQINMKSFLSVMFAPLLYLRPRFRQDQDWSYRQALANTFIKVFLYIFVAFRTKPPLSLKPGLDGDRFVVIEPGAPELYTTIAVDNEIQPVTVGGTWFPSLYQYNTTTTQDKYVVLQFHGGSYILGDGRTSSCQFLANRVLERTPVSHVFSLQYRLACNPNGRFPAQLQDAISAYSYLLHTLHIPASRIVLSGDSAGGHLALALLRYISHFDDEKALPPPTCTWLFSPWCDIPAARNEDLWNNLPNVQTDYIPPSFPKWGAKHFIGNLEITSEVEPYLAPLWHPFILPSPVLIVSGGREVMCQEHDRLARHLGKIQQNEGRVEYFVQDNLPHDVLMVAWILNFRKEADQCAAKAGTFLTRMQSMSEEDATHVPSVAFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W6QN62</accession>
    <name>W6QN62_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Aromatic-ring-hydroxylating dioxygenase, alpha subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PROQFM164_S06g000352</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792020">
        <property type="protein sequence ID" value="CDM37391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QN62"/>
    <dbReference type="STRING" id="1365484.W6QN62"/>
    <dbReference type="OMA" id="FNWKVGA"/>
    <dbReference type="OrthoDB" id="426882at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03469">
        <property type="entry name" value="Rieske_RO_Alpha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="entry name" value="Rieske [2Fe-2S] iron-sulphur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015881">
        <property type="entry name" value="ARHD_Rieske_2Fe_2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001663">
        <property type="entry name" value="Rng_hydr_dOase-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43756">
        <property type="entry name" value="CHOLINE MONOOXYGENASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43756:SF6">
        <property type="entry name" value="CLUSTER-BINDING PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G03920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00090">
        <property type="entry name" value="RNGDIOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="ISP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00570">
        <property type="entry name" value="RING_HYDROXYL_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="8" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="Rieske" evidence="7">
        <location>
            <begin position="88"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM37391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="429" mass="47851" checksum="121CBCA6D5001CF1" modified="2014-04-16" version="1">MDSTDTDYLTSLTSILVAVVTLIFLLHRTWPHLSQPKADKVTKSIAITPLDNSDLTVSKEPEIPEGWWSGREVFELERRALFSQTWLYIAHISQFYKPGSYQSFEIAGFPVFLIRGKDDKIRAFHNVCRHRAYTITRKETGASTVLGCRYHGWSYDTTGRLVKAPQFDDVPGFDKSQNSLFEVHTHTTDQGLIFVNLNSGEPAVFDGVASALSGLAGLRGKSTWVSGLTLSGDFNWKAGTRSRHLDTYTSELHQRMSEVSRPSPAMKLFRAMTGKSSLEKCSLFPITLIYSFQDAGLCLALSFFPASESKTNIRYDLFAHCAVNKPEIQKISEVSQSVTKNLIREIEVEYQSISTKQGSSGELNNTDTRQILCRLQEHTKLERIEGGQILPAMHKPEGSTLFQKADQLCKELDCVSGGSQSGASSALDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W6QNR0</accession>
    <name>W6QNR0_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Glycoside hydrolase, family 32</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PROQFM164_S06g000573</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the glycosyl hydrolase 32 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792020">
        <property type="protein sequence ID" value="CDM37611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QNR0"/>
    <dbReference type="STRING" id="1365484.W6QNR0"/>
    <dbReference type="OMA" id="SGIFDHG"/>
    <dbReference type="OrthoDB" id="202537at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004575">
        <property type="term" value="F:sucrose alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005987">
        <property type="term" value="P:sucrose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18621">
        <property type="entry name" value="GH32_XdINV-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.115.10.20:FF:000011">
        <property type="entry name" value="Glycosyl hydrolases family 32 superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.560">
        <property type="entry name" value="Exo-inulinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001362">
        <property type="entry name" value="Glyco_hydro_32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013189">
        <property type="entry name" value="Glyco_hydro_32_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013148">
        <property type="entry name" value="Glyco_hydro_32_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42800">
        <property type="entry name" value="EXOINULINASE INUD (AFU_ORTHOLOGUE AFUA_5G00480)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42800:SF3">
        <property type="entry name" value="GLYCOSYL HYDROLASE FAMILY 32 N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08244">
        <property type="entry name" value="Glyco_hydro_32C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00251">
        <property type="entry name" value="Glyco_hydro_32N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00640">
        <property type="entry name" value="Glyco_32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 32 N-terminal" evidence="7">
        <location>
            <begin position="29"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 32 C-terminal" evidence="8">
        <location>
            <begin position="424"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM37611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="599" mass="66253" checksum="C5C6161428704574" modified="2014-04-16" version="1">MHGLTHEVNGLSHEEKSLRNPSQWRPSFHVMAPAGWMNDPNGLGYDPKTSLYHLCFQWNPHGNDWGNISWGHAISPDLVSWAISTDPILTPATKYDRLGVFTGCLQATDAFGQPGALTAIYTSVSHLPIRYTLPYTLGSESLSLAVSQDGGKTWERQTCNPFLTGPPPHLNVTGWRDPFITTWAEGPLSKHTPSTLYGFVSGGISKKTPTVFVYTVQATDLSKWEFIGPLIDVGLNLHPSRWSGDYGLNWEVANLMTLTNDTTSRDFIIMGAEGCVPFESSNQDAAQEARRRREPRGQFWISVTSNGEKQSTSTDGALASYAFSGIFDHGCYYAANSFYDPQTSQRIVYGWITEEDLSNTLRHRQGFSGLLSLPRVVGLMTTRNVKKARISELSSITSIEAVPDAPGTGTFTIHTMKINPDSRLARLRQSARESHLADVALSTSPSQSAMLLGTSKWEIDAEFSVSRSCARVGIRILHTHDGQDCTTLSWDPRSETFEIHRPLIDDTEVNHGYETAPHTLFTCLNERGDEVEETLRVHAFFDSSVLEVFVNDRTVISTRIYHPEANCFGLLFFAESDAGVDGDQPAVLVRASIWDGLGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W6QNV6</accession>
    <name>W6QNV6_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="8">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PROQFM164_S04g000640</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QNV6"/>
    <dbReference type="STRING" id="1365484.W6QNV6"/>
    <dbReference type="OMA" id="SDITWGI"/>
    <dbReference type="OrthoDB" id="5296287at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015355">
        <property type="term" value="F:secondary active monocarboxylate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035879">
        <property type="term" value="P:plasma membrane lactate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17316">
        <property type="entry name" value="MFS_SV2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000190">
        <property type="entry name" value="Sugar transporter family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000276">
        <property type="entry name" value="Sugar transporter family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508:SF10">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="179"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="214"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="268"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="306"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="336"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="434"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="57"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="478"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="482"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM35759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="500" mass="54952" checksum="03F56BDFCB5F19D4" modified="2014-04-16" version="1">MDEGKTQYAATSSPDFEEDMSVGRYIATRISSLVPPMNPAPNPFKALTLLNRSQWLNFSVAFLGWSWDSFDFFTVSLTASALAKSFDKSVTDITWGITLVLMLRSVGAITFGIASDRWGRKWPFIVNQLLFVVLELGAGFCQTYKQFLACRALFGIAMGGLYGNAAATALEDCPPEARGIISGLLQQGYAFGYLLATAFARGLVDTTPEGWRPLFWFAAGPPVLIIIFRLFLGETETFRRRQEARQELRGGVAASFISEGKVALQRHWLILIYLVLLMSGFNFMSHGSQDLYPTMLENQFKFSKNAVTVTQVVANLGALSGGVLCGWASQIFGRRFSIIAISIIGGALLYPYTFVQNKNVIAAAYFEQFMVQGAWGVIPIHLMELSPGSIRTFAVGTAYQLGNLVSSASSTIESTIGERFPLPPTEEAAHRYEYGKVICIFMGCVFAYVILITIAGPERLGRNFDAEHDADLQEVAAHRGLNPKEDFGEDPEKATTTIVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W6QRF1</accession>
    <name>W6QRF1_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S18g000001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792032">
        <property type="protein sequence ID" value="CDM38561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QRF1"/>
    <dbReference type="STRING" id="1365484.W6QRF1"/>
    <dbReference type="OrthoDB" id="3350591at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022085">
        <property type="entry name" value="OpdG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053204">
        <property type="entry name" value="Oxopyrrolidines_Biosynth-assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38797:SF4">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38797">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP85-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12311">
        <property type="entry name" value="DUF3632"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM38561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="331" mass="39093" checksum="BE609F46EA1F98D2" modified="2014-04-16" version="1">MEEYKAEWKPFFYPDPEDGDPDPPTWDEIQILQEFVERYGTANAVPVDDAAHRFMSLRNEDDLIQERQSQAVDKGERVSWLLWDAAIEMPNYQPAILKLVEAIRALPDLDRTEEQVRTSRFQDRLEDWRNLAVFKDIWEETHDRYWEMRYGIYPFEGWYTFHSSSAFCAHYLSAYPPHGPGSRELSIALRIPVFALEQEPWKHGPVPLPPPSPSLLQRYHLVDGRVATNYILMLNTDVHAMVPFFEIAGSIIFKFVGKKDLTLAEANKKPDWNLWKGDSSFSKERWDFWKERLQWISEQNELMERTRDDAQKLVEIMHSIEQQTREKNSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W6QRY7</accession>
    <name>W6QRY7_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">GPN-loop GTPase</fullName>
            <ecNumber evidence="7">3.6.5.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">npa3</name>
        <name evidence="9" type="ORF">PROQFM164_S05g000687</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Small GTPase required for proper nuclear import of RNA polymerase II (RNAPII). May act at an RNAP assembly step prior to nuclear import.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Binds to RNA polymerase II.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.-" evidence="7"/>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QRY7"/>
    <dbReference type="STRING" id="1365484.W6QRY7"/>
    <dbReference type="OMA" id="MIIVFNK"/>
    <dbReference type="OrthoDB" id="243313at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17870">
        <property type="entry name" value="GPN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000579">
        <property type="entry name" value="GPN-loop GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030230">
        <property type="entry name" value="Gpn1/Npa3/XAB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231:SF8">
        <property type="entry name" value="GPN-LOOP GTPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231">
        <property type="entry name" value="XPA-BINDING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="277"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="277"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="327"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM36854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="401" mass="44432" checksum="B47C42F835D5E67D" modified="2014-04-16" version="1">MASPVAVVCVGMAGSGKTTFMQRINSYLHEKKTVPYVINLDPAVHSVPFESNIDIRDSINYKEVMKQYNLGPNGGILTSLNLFATKVDQIISLLEKRTAPNPENPSATPIKHILVDTPGQIEVFVWSASGSILLETMATSFPTVIAYVIDTPRASSTSTFMSNMLYACSILYKTKLPMILVFNKTDVKDAEFAKEWMTDFDAFQQALRQEEDAGAFGAEGGAGGFGSGSGYMGSLLNSMSLMLEEFYRHLSVVGVSSMTGDGVEEFFEAVETKRQEFERDYKPELERKKKEREEQSSSQRELELGKLMKDMNVSGSSRQPPRKSTEEPETVSEAEDEEDDIIKRGLADGEDSDYEDYVGPNAGNDEGLTQRYQEALAGSQSTPSEQDNSFTRYLRASNMQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W6QS23</accession>
    <name>W6QS23_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S05g000742</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QS23"/>
    <dbReference type="OMA" id="FCRYANC"/>
    <dbReference type="OrthoDB" id="4327458at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM36909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="195" mass="22189" checksum="60C02A97ACD19C7A" modified="2014-04-16" version="1">MVKYAMHTAYRWYCTLKSREGIDLPQLNDPNTQGEIDLFLGERFCRYANCPKDTPATSTNNLRKHYADKHTDMKLASSGGRPTLQDEHDAVEFYIAIRDEYDANVAAIVQVKPELPRKADGTLHLTNMRKVSKELGGQVPCEPCKDANDRQGCCREANADRCDNFELFVTSAVEEDEEQDNEEGDEMEEGEEMEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W6QSI7</accession>
    <name>W6QSI7_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S06g000034</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792020">
        <property type="protein sequence ID" value="CDM37074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QSI7"/>
    <dbReference type="STRING" id="1365484.W6QSI7"/>
    <dbReference type="OMA" id="SPGNDWM"/>
    <dbReference type="OrthoDB" id="340550at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42106:SF1">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42106">
        <property type="entry name" value="CHROMOSOME 10, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="270"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="409"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="515"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="87"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="196"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="279"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="427"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="448"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="552"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="564"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="578"/>
            <end position="587"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM37074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="630" mass="67243" checksum="39C8468352EE29A1" modified="2014-04-16" version="1">MAQVRPPAPGRSTSAHGFESKLSQQLSQPHETDLEHQLEPSRSPKSRSLSDASRPTSSTQPSTGDLSRASSKDDNAIPVLPATPRRSNASYSNLSLNLPSKPAVSSLTNCAPLSPKLDPSHIYGSPGSVLPRRSRGLDFSRACTNLHHSTLAESSPDSSPTVGGRGMAIPQRRGSLGATSGPPFSTSGPADRATISSSMSSVNMIESDTSSSEEEDESMADRDDVMINTPQATRISAPSPFASNMQSPGNDWMGGYSQAAASLMSFQRARFRKGRSRHSSSSASGNSTKPSPTPHSPPIMKSVEHSSGYFAPRQTAHSRRESLSFGTRDLRLSDMSDDSESRTTRSGSPIPTPRPEGGGPLGVIRRAVTRRGSLLPKTKTFARIRAALMEEGAPVDSDMKREAEVVRQVRDTEPEPTPALGEFPSLRPSTSLDSTATEDPAVRVGMDTGSTDTFGKQASRNSGGLEFWNSFDGRYRTPPPVRQGGPSSVADEDMFMDMTPSTTMGSVTAESFKQRSRSSTPHAPGMPSIGEICRKRRRDDDFDPNLFKRRAVSPSVSAQSSPVMTHSHNISDTGPNIWGPPPKPGLGPPFSERLSSDVGNRPIAHAGGAKRVGLQGMTEASDGFMNMSID</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W6QTY7</accession>
    <name>W6QTY7_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="21">Endoplasmic oxidoreductin-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">ero-1</name>
        <name evidence="21" type="ORF">PROQFM164_S02g003153</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">FM164</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 17">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">May function both as a monomer and a homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Lumenal side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the EROs family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM33002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QTY7"/>
    <dbReference type="STRING" id="1365484.W6QTY7"/>
    <dbReference type="OMA" id="CYKDRLH"/>
    <dbReference type="OrthoDB" id="269384at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016972">
        <property type="term" value="F:thiol oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007266">
        <property type="entry name" value="Ero1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037192">
        <property type="entry name" value="ERO1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12613:SF0">
        <property type="entry name" value="ERO1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12613">
        <property type="entry name" value="ERO1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04137">
        <property type="entry name" value="ERO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017205">
        <property type="entry name" value="ERO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110019">
        <property type="entry name" value="ERO1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 18" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 17" id="KW-0274">FAD</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 20" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="20">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004880117" evidence="20">
        <location>
            <begin position="22"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="121"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="135"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="16">
        <location>
            <position position="400"/>
        </location>
    </feature>
    <feature type="active site" evidence="16">
        <location>
            <position position="403"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="271"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="303"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="18">
        <location>
            <begin position="94"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="18">
        <location>
            <begin position="400"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR017205-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR017205-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR017205-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="CDM33002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="612" mass="69647" checksum="B87FE49E9E75871E" modified="2014-04-16" version="1">MRSAARLLYAAVFALASLSHAAVHNPALDPTKCAIEPSAMVSDACVTYGEINGMNDLIFTTLNSLTQETDFFSYYRLNLFNRQCPFWNDANSMCGNIACAVNTIDSEEDIPLTWRAEELSKLEGPKANHPPRNIQAERPKERPLQGELGEDVGESCVVEYDDECEERDYCVPEDEGSAGKGDYVSLVDNPERFTGYSGEGANQVWDAIYRENCFLKPVAEELEEQSVNVPIGGLQAASDFRDVLQKESQRVESLSLDNECLEKRVFHRLLSGMHASISTHLCWDYLNQTTGLWHPNVQCFKDRLLDHPERISNMYFNYALVSRAVAKLRKHLDGYTYCASDPVQDRETKKRVNKLTATLTELPQIFDEKIMFQDANAIGLKEDFRNRFRNVSRLMDCVGCDKCRLWGKLQVNGYGTALKVLFEYDETKNGENPPLRRTELVALINTLGRISHSIAASRSMQRALLTGTTHMFPVHGAVPSSHHANALGDNRRVFSDGNNNFYFEGEDNEDDYVYGRGAAPERYPWERKPPGPDDGWVEDFMSEWNMIWGTVGYIWQSWLDIPFTIYQIGTSEFIRLYNYWLGLPVPPRMWKLKTPQPRAHTQPAAYANRDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W6QUZ1</accession>
    <name>W6QUZ1_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S03</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S03g000091</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QUZ1"/>
    <dbReference type="STRING" id="1365484.W6QUZ1"/>
    <dbReference type="OMA" id="WRAILTI"/>
    <dbReference type="OrthoDB" id="5273928at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="348"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="348"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM33367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="391" mass="45221" checksum="216469E6B850C5D4" modified="2014-04-16" version="1">MSIILEDDHPPAVLRFGPTWYHEIPFLPYGLETTNDQGSGSLKHAAMKALLRDQSALKPELFEYVHWYLAKYLWDALKKYNKQTMHMWKIMASNYPVQFYEISPYYCLNAGCPKKPLRDYMGILNSDDLRWRAILTIATTYCTASDFTTIPNIKNLVALDIYREKYASNSPPLDPVGVSNDLQDGFVRGWIESEALQHLRILRLYHQCEITVAAVGALRELPELQLIVAYECKNITETIQKYDRPANNIIPIKGWSACRLDWYWETHGTSKTIDNNLLALFHVYQASLQTPGDEHSKRPSSLPTNLPILEFKLPTVDHSRRDKIVVRSRYNAKSIVLFTRDPVKQKFDIEKRRARDKKRTEPPEGGDRPAKRAVMKERGPMDISKTLNQFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W6QVY1</accession>
    <name>W6QVY1_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Short-chain dehydrogenase/reductase SDR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S03g000456</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QVY1"/>
    <dbReference type="STRING" id="1365484.W6QVY1"/>
    <dbReference type="OMA" id="KDANTMF"/>
    <dbReference type="OrthoDB" id="1669814at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050664">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000245">
        <property type="entry name" value="Short chain dehydrogenase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008">
        <property type="entry name" value="BENZIL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008:SF4">
        <property type="entry name" value="CHAIN DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G08710)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM33732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="286" mass="31096" checksum="F80D70751C7C53CF" modified="2014-04-16" version="1">MSVSIETTTVPTAPITAQPVLLGQKSRMPEFSLAGKVVLVSGAARGLGLTQTEALLEAGAKVYALDRLEEPAPEFEQIQQRAMELGTELHYRRIDVRDTELLNSVIETIANEEGRMDGLIAAAGIQQETPALEYSAKDSNTMFEVNVTGVFMTAQAVAKQMIRFGNGGSIAMIASMSGTIANRGLICPAYNASKAAVLQLARNLASEWGTYNIRVNTISPGYIVTAMVEKLFLEFPERRDQWPKENMLARLSRPEEYRGAAVFLISDASSFMTGSDLRMDGGHAAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W6QWR6</accession>
    <name>W6QWR6_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Probable transposable element</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S30g000001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792044">
        <property type="protein sequence ID" value="CDM38600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QWR6"/>
    <dbReference type="STRING" id="1365484.W6QWR6"/>
    <dbReference type="OMA" id="WAYCVER"/>
    <dbReference type="OrthoDB" id="4362751at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM38600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="113" mass="12630" checksum="D26112638222F381" modified="2014-04-16" version="1">MKARGIPDDLLRRSGATFKAEKTAIIYFAPKICKSDHKSFIIKEQTVVPKEHIKILGILIDTRLKYKEHIARAASKGLEAAIELRRLRGLSLATARQLFTLTVAPVIDYASNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W6QXZ4</accession>
    <name>W6QXZ4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding SAP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PROQFM164_S03g001131</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the SAP domain-containing ribonucleoprotein family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QXZ4"/>
    <dbReference type="STRING" id="1365484.W6QXZ4"/>
    <dbReference type="OMA" id="WSEKDNA"/>
    <dbReference type="OrthoDB" id="445357at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.30">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052240">
        <property type="entry name" value="SAP_domain_ribonucleoprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040746">
        <property type="entry name" value="THO1_MOS11_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46551">
        <property type="entry name" value="SAP DOMAIN-CONTAINING RIBONUCLEOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46551:SF1">
        <property type="entry name" value="SAP DOMAIN-CONTAINING RIBONUCLEOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02037">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18592">
        <property type="entry name" value="Tho1_MOS11_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00513">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68906">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAP" evidence="4">
        <location>
            <begin position="5"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="23"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="87"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="182"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="44"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="59"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="100"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="209"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="235"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="289"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00046328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDM34407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="308" mass="33107" checksum="EE92B7D4F3A48402" modified="2014-04-16" version="1">MATDYSKKTNAELVEILKTRSLPHTGKKADMVSRLQEDDESKPSDAPAAAPAAAKTDAPEDVIDWDDEPAETVIEPSTETGAAAIAAGGQGAVSNPVAVPNQQLDENPATTDDLKVETTGAVAEPATQPEAAVEQKPAVDYTRGLPQTDLEAELEKRKARAQKFGIVEDDDTALKEATKQLERAKRFGTGAEADTTPAAGLSRLDQALPDERSRKRRNENRSDNRNEQGGRGGKRRDTGRNRNRQRGDGNRNRDRGDRGDRGDRADGGNRTNAGVKKPNAGANTAQKSWSEKDNAAMEARKKRFAAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W6R170</accession>
    <name>W6R170_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Genomic scaffold, ProqFM164S04</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S04g000458</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6R170"/>
    <dbReference type="STRING" id="1365484.W6R170"/>
    <dbReference type="OMA" id="KAKCFYF"/>
    <dbReference type="OrthoDB" id="9936937at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058841">
        <property type="entry name" value="HTH_76"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040554">
        <property type="entry name" value="KPWE_PEX14_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36855">
        <property type="entry name" value="CHROMOSOME 10, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36855:SF1">
        <property type="entry name" value="PEROXISOME MEMBRANE ANCHOR PROTEIN PEX14P N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25871">
        <property type="entry name" value="HTH_76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17733">
        <property type="entry name" value="KPWE_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PEX14-like helix-turn-helix" evidence="3">
        <location>
            <begin position="8"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="Peroxisomal membrane protein PEX14-like KPWE" evidence="2">
        <location>
            <begin position="116"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM35577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="172" mass="18846" checksum="A32F31310FED9688" modified="2014-04-16" version="1">MAQASQAQIFERLHSYPFISDPEFANGLSIILGHPDTPATEVEMNRDDDLVLKAKCFFFSRKENLTPAIDFSAFKSWLASRTTEPQGLGNTDLQISKASDPSTSGAESSTRSEPAYPSSFAHIVELITTGQPIPGIQDIPDTVLSGHDISSEKPRRRKPWEKDEVDTPSAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>W6R2X9</accession>
    <name>W6R2X9_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Alanine--tRNA ligase</fullName>
            <ecNumber evidence="15">6.1.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Alanyl-tRNA synthetase</fullName>
            <shortName evidence="15">AlaRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">ala1</name>
        <name evidence="15" type="synonym">ALA1</name>
        <name evidence="17" type="ORF">PROQFM164_S05g000010</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14 15">Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 15">
            <text>tRNA(Ala) + L-alanine + ATP = L-alanyl-tRNA(Ala) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:12540"/>
            <dbReference type="Rhea" id="RHEA-COMP:9657"/>
            <dbReference type="Rhea" id="RHEA-COMP:9923"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78497"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="15">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="15">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="15">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="15">Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family. Alax-L subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.7" evidence="15"/>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6R2X9"/>
    <dbReference type="STRING" id="1365484.W6R2X9"/>
    <dbReference type="OMA" id="NKKDNFW"/>
    <dbReference type="OrthoDB" id="2423964at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004813">
        <property type="term" value="F:alanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070143">
        <property type="term" value="P:mitochondrial alanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00673">
        <property type="entry name" value="AlaRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.130:FF:000004">
        <property type="entry name" value="Alanine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.310.40:FF:000003">
        <property type="entry name" value="Alanine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000011">
        <property type="entry name" value="Alanine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.980.10:FF:000004">
        <property type="entry name" value="Alanine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.980.10">
        <property type="entry name" value="Threonyl-trna Synthetase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00036_B">
        <property type="entry name" value="Ala_tRNA_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002318">
        <property type="entry name" value="Ala-tRNA-lgiase_IIc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018162">
        <property type="entry name" value="Ala-tRNA-ligase_IIc_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018165">
        <property type="entry name" value="Ala-tRNA-synth_IIc_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018164">
        <property type="entry name" value="Ala-tRNA-synth_IIc_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050058">
        <property type="entry name" value="Ala-tRNA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059090">
        <property type="entry name" value="ALA1_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023033">
        <property type="entry name" value="Ala_tRNA_ligase_euk/bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003156">
        <property type="entry name" value="DHHA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00344">
        <property type="entry name" value="alaS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11777:SF9">
        <property type="entry name" value="ALANINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11777">
        <property type="entry name" value="ALANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26023">
        <property type="entry name" value="ALA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02272">
        <property type="entry name" value="DHHA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01411">
        <property type="entry name" value="tRNA-synt_2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00980">
        <property type="entry name" value="TRNASYNTHALA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101353">
        <property type="entry name" value="Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="ThrRS/AlaRS common domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50860">
        <property type="entry name" value="AA_TRNA_LIGASE_II_ALA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 15 17" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 15" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 15" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 15" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10 15" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 15" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 15" id="KW-0820">tRNA-binding</keyword>
    <keyword evidence="7 15" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alanyl-transfer RNA synthetases family profile" evidence="16">
        <location>
            <begin position="51"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="644"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="648"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="763"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="767"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00055137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CDM36177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="1001" mass="111601" checksum="35FF5B5D3106F713" modified="2014-04-16" version="1">MRVSGVVTNGERALTHLFRRNQPRTFFPCLVHSLSTKHPTFDRMTSLGPEWTAQRVRDTFLDYFKQNGHTFVPSSPVAPLSDPTLLFTNAGMNQFKSIFLGTVDASSDFGKMKRATNSQKCLRAGGKHNDLDDVGKDSYHHTFFEMLGNWSFGDYFKKEAITYSWTLLTEVYGLDPDRLYVTYFEGNEAGGLEPDLEAKEIWKSVGVPESHILPGDMKDNFWEMGDQGPCGPCSEVHYDRIGGRNAAHLVNEDDPNVLEIWNNVFIQYNREPDSSLRPLPNKHVDTGMGFERLVSILQDKPSNYDTDVFTPIFQAIQNATGAREYRGHFGADDADGIDTAYRVIADHVRTLMFAISDGVIPNNEGRGYVIRRVLRRGARYARKYFQVDIGNFFAKLVPTVVDQLGEMFPELKRKQQDVIEILDEEELSFAKTLDRGERQFEQYAQHAKAKGTDMLHGADVWRLYDTFGFPVDLTRIMAEERGLRIDDVEFEEARLKAKEASKGQKKAADNTVKLDVHDLGNLEKMNDVQKTDDSPKFGRGNITSHVKAIYHGKTFHNSTDDVPEGAQLGVILDRTNFYAEQGGQENDTGKIIIDGQAELEVGDVQSYAGYVLHTGFMKYGSFSVGNSVICEYDELRRWPIRNNHTGTHILNFALKEILGDGVDQKGSLVAAEKLRFDFSHKSAISDAELEKIEAKATDYIRQNCAVYSQELPLATAQQISGVRAVFGETYPDPVRVVSVGVELEEILQNVKDPRWQEVSIEFCGGTHVQKTGDIKDLIILEESGIAKGIRRIIAVTGEDAHEVQRVAEEFGQRLDRLDALPLGSEKEQEAKQVQVDLNQLAISAVRKAKFRERFAKINKQVLDDQKAQQKLESKKAVDAITSYFEAPENQDKSWLVVQLPISANAKAVSESLNHVKSKMQGKSVYLLAADSEQGRVSHGCYISQALSDQGASASDWAAVVSGAVGGKAGGKGPTSIGNGTNADKVEEAISLAADYLNKFKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W6R3R5</accession>
    <name>W6R3R5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S05g000280</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6R3R5"/>
    <dbReference type="STRING" id="1365484.W6R3R5"/>
    <dbReference type="OMA" id="EKEYSTY"/>
    <dbReference type="OrthoDB" id="4177740at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM36447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="347" mass="39897" checksum="807C4360768D2E6B" modified="2014-04-16" version="1">MSSQPVNPPMLQDHDALRKMFEEKADSILEWLESKSQVSYDYDTLREIGVLLHHMDVTYDQESLDFKLLSEKEYSTYKIDSARIPKHMRHHYDGFDKAFHLSFSYPLSDPLPGTELVYEKAFQIARYIDILQDYSKKDDPDNTSSIEKNSNWYEILAEDSFEDGPQGMLHGLHIGHSKPLDLSRWRAVSYRQWQEDPEDPDTIRPHVMLMICTGAVAKSNNLLHGEIGPIVNTIQCRLLQEEFKQTSSFPVLVISLFGPRQGRMLYARFNIDGTLIVRASDIFDFKKKNQEGFDLFMRYYNCEPEDTAVLSKTLHLPLSPSAVPRKSGIVDTPITSFSVSENVPHAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W6R4E0</accession>
    <name>W6R4E0_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S05g000515</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6R4E0"/>
    <dbReference type="OrthoDB" id="5401170at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM36682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="109" mass="12796" checksum="651893C6666A4A3D" modified="2014-04-16" version="1">MADYVPGGYINYVVWTRVAGEPINSVPYWKRDLEYREEVRSVFRATYKWLRQPTNIDNGELMLSGHISGFRDPDNLDPTPLSDVTYAILRLVRSAHRVDWMRDSSDWKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W6R786</accession>
    <name>W6R786_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S07g000055</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792021">
        <property type="protein sequence ID" value="CDM37707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6R786"/>
    <dbReference type="OrthoDB" id="10417564at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM37707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="59" mass="6808" checksum="EEB1584B40CEEA34" modified="2014-04-16" version="1">MRVPSASQIPDFWKRGKKPCLNWDAAVSDSTVKREHTKRHTRMSLQDSVLNPCLNQVKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W6R898</accession>
    <name>W6R898_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">gamma-glutamylcyclotransferase</fullName>
            <ecNumber evidence="1">4.3.2.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PROQFM164_S09g000008</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM164</strain>
        </source>
    </reference>
    <dbReference type="EC" id="4.3.2.9" evidence="1"/>
    <dbReference type="EMBL" id="HG792023">
        <property type="protein sequence ID" value="CDM38092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6R898"/>
    <dbReference type="STRING" id="1365484.W6R898"/>
    <dbReference type="OMA" id="CLLWTMW"/>
    <dbReference type="OrthoDB" id="2017317at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003839">
        <property type="term" value="F:gamma-glutamylcyclotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.10">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017939">
        <property type="entry name" value="G-Glutamylcylcotransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12935">
        <property type="entry name" value="GAMMA-GLUTAMYLCYCLOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12935:SF0">
        <property type="entry name" value="GAMMA-GLUTAMYLCYCLOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13772">
        <property type="entry name" value="AIG2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="42"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR617939-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR617939-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDM38092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="190" mass="22043" checksum="9F822E668D9C6158" modified="2014-04-16" version="1">MGVPYTDPAMGGLRPAEEQDIPVYGIAYLLSPDDMRKVIISEGGGIAYKAEVFTATLQNDASEVSVHLLVGRHSISRSYERLPSRRYMDLLIRGAREHSLPESYQKRLLSQQTFIPGQSCRFKVGKWLFDGFWQRIAYWIEKGVYKFKDGEGNVPPWFLVIFDFLLWIMWYYHDYVHSVIWGRGDGLNRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W6R8C7</accession>
    <name>W6R8C7_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S09g000038</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792023">
        <property type="protein sequence ID" value="CDM38122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6R8C7"/>
    <dbReference type="STRING" id="1365484.W6R8C7"/>
    <dbReference type="OMA" id="EYSVHVN"/>
    <dbReference type="OrthoDB" id="2555519at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38701">
        <property type="entry name" value="CHROMOSOME 8, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38701:SF1">
        <property type="entry name" value="UP-REGULATED DURING SEPTATION PROTEIN 1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="343"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="384"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="112"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="129"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="203"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="220"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM38122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="598" mass="64594" checksum="096B93E841DAA269" modified="2014-04-16" version="1">MTYDKQNNGSIAKPFTPTLSAAFHRSNRAPLTPKLASPSPGPGFPRRLAQPDHPYSKDDSPAVPTFLSANVTPRSGPRTTRRDGAIYSPTNTSPAPSPSPNPPYSQSTIGYGRRDRSPARGVKPEQSRTLRSKTLTADNQPRSRLNSFSDTTSGTPLFFHASDARSSHPSEPSDAPRPRPQGKTSPASSFIYANGDQERKSLGEQSNVTSASAKRRSGGLPRPLSASKPPPSSSRLSSPGLPDVASHPPEDIRLPYVTSIESGLGISPRLGSPSSSTIGERPRPHPIRHTKSSSVDSGRHGNYLQDSLRASPVIVSGSHFGEEPAPVMSEQIPALRPRIFSNVSTTSTDTYPPVPLSPGKSEGPSEAALNARIERKIMDLEISNSSLLAINRTLEREMRQQKAELRRFRRLSRSGRISMAPSTRSFSGAALSVTSELNEGASEISNLSQDDMSDISDEDSIVDESILSPGSLAEHNAKNRVNDEKRVMLDLARHQEVLVDSQKMNQSLKRCLGWTEELIKEGQRALEYNVHVQDVELGGRVLAPEELGEIGESGRGLLSPSVQYNASFSPMEASELSFTESLYIGTLSPTPSISDPST</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W6R985</accession>
    <name>W6R985_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S12g000026</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792026">
        <property type="protein sequence ID" value="CDM38417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6R985"/>
    <dbReference type="STRING" id="1365484.W6R985"/>
    <dbReference type="OMA" id="FCKVEET"/>
    <dbReference type="OrthoDB" id="4485682at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021842">
        <property type="entry name" value="DUF3435"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37535:SF2">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G09300)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37535">
        <property type="entry name" value="FLUG DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11917">
        <property type="entry name" value="DUF3435"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM38417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="363" mass="42165" checksum="45A7089C14E6C239" modified="2014-04-16" version="1">MSPLPPGIRKLIDKFELDDQERGKEPVYVQDLTELNETILRTQERGFNFGYERIQMCLFSMLGIFTVNRLSALLSLQLKHLQFSIQKDPQGGPPVLLAEVRSEHTKRFFGSEAMLLNPRSSKPTMNLPGIHGWLQSMFAHRMRYGGGKMLNNSDSVSEAQQNLIMKHADRTFLNHYLPRHVDTDMQNVMNGRQSNKSLMRAITRMSRWIDTRRPRHLTPEQRASIREHPEYVEAVRRLDEQAELCIYDPSEQMQLRRDRLAREKLNTFGRLERALRQKVRKEFDRKQANLDIERQLSGAAIDNEEAKNVLRTDSMLSEQIDLLEKLLTWPTSHSLEAERQRRNAAVAAISQYCHHLEGGPLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W6R9Q2</accession>
    <name>W6R9Q2_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mitochondrial chaperone BCS1-like ATPase lid domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S29g000004</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792043">
        <property type="protein sequence ID" value="CDM38598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6R9Q2"/>
    <dbReference type="STRING" id="1365484.W6R9Q2"/>
    <dbReference type="OMA" id="FHIVFKR"/>
    <dbReference type="OrthoDB" id="4355580at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057495">
        <property type="entry name" value="AAA_lid_BCS1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25426">
        <property type="entry name" value="AAA_lid_BCS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mitochondrial chaperone BCS1-like ATPase lid" evidence="3">
        <location>
            <begin position="66"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM38598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="122" mass="13983" checksum="619A1A3687F5E9EF" modified="2014-04-16" version="1">MALFTKLPPHCIVLLEDVDAADEALIRPSRTDKKVHFKLTDETTSTQLFHIVFKRTLDFKQPEERFGDEIIDRLAENFASKVPDQVFSPTKVLLFLLERKNSPIDTVNGIKDWVTRVKEAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W6PSE4</accession>
    <name>W6PSE4_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ATP synthase subunit K, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PROQFM164_S01g000569</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5">FM164</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="CDM26760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    </dbReference>
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            <begin position="12"/>
            <end position="33"/>
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    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="76" mass="7978" checksum="CB53F80A79D11629" modified="2014-04-16" version="1">MVVYYQIAGKKVGSHVLAMATLGSIFAGSWLAVSGGEKPKTAQGPPINASSKDEENFVQNFMKEIDGGEKKPAAGH</sequence>
</entry>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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                <person name="Dupont J."/>
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        </location>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="149" mass="16947" checksum="218DEA9AA23F3E1A" modified="2014-04-16" version="1">MALPKRIIKETERLMAEPVPGINAVPHDDNLRYFDVSIHGPAQSPYEGGIFRLELFLPDDYPMTPPKIRFLTKIYHPNIDRLGRICLDVLKNNWSPALQIRTILLSIQALLGAPNPDDPLANDVAQRWKDDEPAAIQTAKEWTRTHAMD</sequence>
</entry>
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    <accession>W6PU73</accession>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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                <person name="Dupont J."/>
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                <person name="Conseiller E."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1">FM164</strain>
        </source>
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    </dbReference>
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        <source>
            <dbReference type="EMBL" id="CDM27430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="115" mass="12662" checksum="08DFA2A98175AD43" modified="2014-04-16" version="1">MGPAKSIRNKFQLTSDAFPRSGKAHALEPLSHALYAWTQSRHRFAVAPWTAGFFFGNGNVVQGWLSQVISIVGQFLNGSIARSMEPFKVITAPLPRPRDASSHAIWPCRADLRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W6PUB0</accession>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
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                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
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                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="entry name" value="CENTROSOMAL PROTEIN 2"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR23159:SF31">
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="414"/>
            <end position="434"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="905"/>
            <end position="1077"/>
        </location>
    </feature>
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        <location>
            <begin position="108"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="289"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="752"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="43"/>
            <end position="55"/>
        </location>
    </feature>
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        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="955"/>
            <end position="970"/>
        </location>
    </feature>
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        <location>
            <begin position="971"/>
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        </location>
    </feature>
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        <location>
            <begin position="1025"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1066"/>
            <end position="1077"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM27475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="1077" mass="119889" checksum="973FA388117EA387" modified="2014-04-16" version="1">MASRMDVDSPNLNPRKRLSGLLLPGSSPTKAQDPRLAGAVRQSVDSQSSTAQQAHLNLPATPALIQKSPAKSLPQVSPLSIPNSAAGPTSIESPSAPIRQGALSISDLVNSLIKVNKCEEEKEKLQNEIVSITKNLQRAKQSQQFPSVIALFQQQLDAAKNELDIHVKSIMQHRLLSNQAQDNFNSTLSQYKPQSQLEKIPERVGNLESTIKEMREGLGPTSSGDNPMKGNAEFDRVQTHMRSQGQDIDELKRNLDKVQHSLENPNGLDEVMGYMNRIANSVSHQMKRNGQFTNKISELEDEVKAADKKFDDKISTVEKMVDTVEEELRNSNQKLETNISDLGGKLKTANEHAEGKLRDIESNLRSLNNKRHDLNNSASTQISQIETDLETQRQETTAQITAQEDHLASLRTQQQNIDNGGGPSSEATPTPHSGVLTRMVSLERRVQEYTTFLNKIKDLHHEVDVARLDELSALRRNQESSQKSLETKQHEILRKVQDLTANSKEMNTNQKIFAVGLHQLRTSLPESLQRLQNDLKNGLDAFETRLTPVSDLPRAVTKCESKIESLSRGIRSLETRWSNITTGDLVNSMAHAMQQMYPSVDKLSHQLTAYQTEIDGRISALQRDTETFKADTNRFKADTENAQVCAARSQAAHVSSEQLQTLTRLPTLLQEVKGLSDKIEPIEKAIKEHSDEFQRNLHQWSDLSNRISAQDDTIGGMDQTASEQSAQFDNINQSIRKIDPFIGKIDAHFSALESVQKAIAELRKAAEERDATTQNGLGNISMRLESLEGRNKTEDEVLNELRKQMKDLEARSTAEKADLGVLRTKLKELEGHNATEENDFGKLREKVKALEEREPPVSLEKFTEQGDEVKMYIKRLRKAEDTFKALAGGAKISDILDRPMEERIDGQETPQSQPNGRAFIPRLTTTPKTVPMGPALGSYQPVQVNGKGPAENCPPSGSKSNHTAMQARQRSQTPSGPSSGHPSPYSGKSAEPRQVQHLKGKRRVSSVIDSDDERNTTECSSVIDYSPAPSSSGPSYFASGSNRKDKKRAKKRAEQAEDLFYSSSRPGKKRKRNKQDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W6PV25</accession>
    <name>W6PV25_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Hydantoinase/dihydropyrimidinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PROQFM164_S01g001457</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM164</strain>
        </source>
    </reference>
    <comment type="PTM">
        <text evidence="3">Carbamylation allows a single lysine to coordinate two divalent metal cations.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PV25"/>
    <dbReference type="STRING" id="1365484.W6PV25"/>
    <dbReference type="OMA" id="SAETHHM"/>
    <dbReference type="OrthoDB" id="1924787at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01314">
        <property type="entry name" value="D-HYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000217">
        <property type="entry name" value="Dihydropyrimidinase-related protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011778">
        <property type="entry name" value="Hydantoinase/dihydroPyrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050378">
        <property type="entry name" value="Metallo-dep_Hydrolases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02033">
        <property type="entry name" value="D-hydantoinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11647:SF96">
        <property type="entry name" value="AMIDOHYDROLASE-RELATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11647">
        <property type="entry name" value="HYDRANTOINASE/DIHYDROPYRIMIDINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="4">
        <location>
            <begin position="60"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-carboxylysine" evidence="3">
        <location>
            <position position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR611778-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDM27646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="498" mass="54927" checksum="C8E4679EBC30B365" modified="2014-04-16" version="1">MSEQLNPDLDLIVLNCTLATVEDVVQCDIGVKDEKIHSIVPQGSLAGSKAKKIIDAKGALVTPGGIDAHVHLQEPPLFGLGSTADNFESGTRAAIAGGTTTIVAFAPQRKHEDSVLATLACAHERAQDQCYSDYSFHLIISNPCAKTLAEFPAFRDLGISSVKIYMTYEALRLNDEQFLDVLFQSRLHKVTTMVHAENDSVIAWMTKKLHERQLYAPKYHTASHPAVAEIEASYRAICLSEFIDTPILIVHVSNPRAVDNIRQAQAKGLPIYAETCPQYLFLSSENLDRPGLEGAKCVCSPPLRNKSDHEAIWAGLEDGTFTILSSDHSPFNFNDSTSGKGSSVTTERPDGQFHLIPNGFSGVETRMPLVLSADRLNIQKYVELTSTNPAKLYGMYPRKGALIPEVSDADFVIWYPEGSLAMTVTNDILHHNVDYTPFEGHKVKQWPRYTVLRGHIVWDREDGGVVGSRGFGQFLHRTESMMAGSRSEGSWDVETAWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W6PVD2</accession>
    <name>W6PVD2_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Purine-cytosine permease fcyB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">fcyB</name>
        <name evidence="11" type="ORF">PROQFM164_S01g001547</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PVD2"/>
    <dbReference type="STRING" id="1365484.W6PVD2"/>
    <dbReference type="OMA" id="LWLSANM"/>
    <dbReference type="OrthoDB" id="2116389at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015851">
        <property type="term" value="P:nucleobase transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11484">
        <property type="entry name" value="SLC-NCS1sbd_CobB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.4160.10:FF:000002">
        <property type="entry name" value="Purine-cytosine permease fcyB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4160.10">
        <property type="entry name" value="Hydantoin permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026030">
        <property type="entry name" value="Pur-cyt_permease_Fcy2/21/22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806">
        <property type="entry name" value="PURINE-CYTOSINE PERMEASE FCY2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806:SF1">
        <property type="entry name" value="PURINE-CYTOSINE PERMEASE FCY2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002744">
        <property type="entry name" value="Pur-cyt_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="114"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="189"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="218"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="289"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="389"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="420"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="460"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="495"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="17"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR002744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDM27736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="526" mass="57158" checksum="4B60CBE16514E09A" modified="2014-04-16" version="1">MASKMFPSHEDLEKAPQVNNASEQNSNKLFDNSSDGAVPGESFEYGNSLYAKIQRLAGKLNIEQRGVERVPEHERTDTSYLNIGSMWLAANMVVSSFAIGVLGKSAFDLGFVDAILVCLFFNLLGVMTVCYFSCFGPMFGLRQMVLSRFWFGWWPVKFIAVLNIIACVGWSAANAIVGAQLLNAVNSKVPGFAGILIITFCTLFVTFAGYKYVHMYEYWSWIPTCIVFFIVLGTFAHSGDFVNIPMGVGVSEMGACLSFGSTVYGFATGWTSYAADYTVYQPKTQSRRLVFLSAWLGLIVPLLFTQFLGIAVMSATAMGDGVHNKYAEGYAASVNGGLLAAVLEPLGGFGKFCLVVLALSIIANNCPNIYSVGLTLQVLSRATQRVPRFIWTFLASCASLAIAIPGYSHFETVLENFMALIAYWLAIYSGIVLADHFVFRRGFGGYSAEDYDDPKKLPMGIAAAIAFAFGVAGVVVGMSQTWWMGPIAAHAGDPTYGGDVGFELGFAFAAAVYCILRPIELRMIGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W6PVH5</accession>
    <name>W6PVH5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aldolase-type TIM barrel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S01g001572</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PVH5"/>
    <dbReference type="STRING" id="1365484.W6PVH5"/>
    <dbReference type="OMA" id="RAKPKAW"/>
    <dbReference type="OrthoDB" id="10265891at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018580">
        <property type="term" value="F:nitronate monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04730">
        <property type="entry name" value="NPD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004136">
        <property type="entry name" value="NMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332:SF31">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G09850)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03060">
        <property type="entry name" value="NMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51412">
        <property type="entry name" value="Inosine monophosphate dehydrogenase (IMPDH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM27761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="355" mass="37633" checksum="CE3A9532FBBB7E46" modified="2014-04-16" version="1">MASPQQIRTPITDLLKINHPILLAGMNVAAGPKLAAAVTNAGGLGVIGGVGYSPEMLREQIAELKSYLNDKNAPFGVDLLLPQVGGSARKTNYDYTKGKLGELVDIIIQEKASLFVSAVGVPPKAVVDKLHSAGILCMNMIGHPKHVQKALDVGIDIICAQGGEGGGHTGDVPTTILIPTVAKLVEGKKSPLTGQPVQVIAAGGLFNGNSVAAALMLGASAVWIGTRFILADEAGAPAAHQEAVRTSNFEDNIRTIIFTGRPLRVRKNPYIVNWEENRHDEIKELTSKGIIPVEHDMENLPDDVDDETLDNARPWLMGKVAAVVNEKKPAKAIVDELVSDAAVLLQKGNKMVAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W6PVL3</accession>
    <name>W6PVL3_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosomal protein L34</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PROQFM164_S01g001617</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL34 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PVL3"/>
    <dbReference type="STRING" id="1365484.W6PVL3"/>
    <dbReference type="OMA" id="TMNGHTR"/>
    <dbReference type="OrthoDB" id="431691at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.3980">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000271">
        <property type="entry name" value="Ribosomal_bL34"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01030">
        <property type="entry name" value="rpmH_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14503:SF4">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL34M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14503">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN 34 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00468">
        <property type="entry name" value="Ribosomal_L34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="90"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDM27806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="109" mass="12226" checksum="786269A7945BBD7C" modified="2014-04-16" version="1">MLSSRSFSSLLSTPTRFQPSRTIGGRLSSPTTTATATAFSPLSSLLSQKTPSQRRSFSASASLGVRRVTFSPSRRVQKRRHGYLARKKDRNGRKTLIRRTLKGRKELSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W6PWH6</accession>
    <name>W6PWH6_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S01g000093</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PWH6"/>
    <dbReference type="STRING" id="1365484.W6PWH6"/>
    <dbReference type="OrthoDB" id="6499973at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM26284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="85" mass="10307" checksum="D7964DB71BA7834B" modified="2014-04-16" version="1">MSLLRKPLKQYPWLPWSIRNIYDWLHYSEPTWGYTIYRTTYTPQSNAAFPRMVDLTTKYMKNGFYGEYEPSLRERSNANEFNITP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W6PWS4</accession>
    <name>W6PWS4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ribosomal protein S15</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PROQFM164_S01g002196</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS15 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PWS4"/>
    <dbReference type="STRING" id="1365484.W6PWS4"/>
    <dbReference type="OMA" id="HLQEHRN"/>
    <dbReference type="OrthoDB" id="441444at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00353">
        <property type="entry name" value="Ribosomal_S15p_S13e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.10">
        <property type="entry name" value="S15/NS1, RNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01343_B">
        <property type="entry name" value="Ribosomal_uS15_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000589">
        <property type="entry name" value="Ribosomal_uS15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005290">
        <property type="entry name" value="Ribosomal_uS15_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009068">
        <property type="entry name" value="uS15_NS1_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23321">
        <property type="entry name" value="RIBOSOMAL PROTEIN S15, BACTERIAL AND ORGANELLAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23321:SF26">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US15M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00312">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01387">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47060">
        <property type="entry name" value="S15/NS1 RNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDM28385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="300" mass="33335" checksum="5B12F131C49B79D8" modified="2014-04-16" version="1">MPPRVSVQSSLKALTGSTYGYTPLSNSINTTTRAVSSKVQIRKKHDPFLMAQARQRKAANVSRQKVLAEERNSSVGDPVKSQPTPFILEMTAIQTNSHIPSSLAGDLNYYLKSNELDAALDFSKDLTAPLKNPDRNTADPQVEKEAVNLHNQEHKNAQEAINRIVNLNNGNTKDRVRLNITKCIETFGRHYTDLNLPPKPSAVVHGSAPVHPERAPRVGPDTGSAEVQAAILTVKIMNLSRHLETANKDKHNKRNMQLLVHKRQKLLQYVRKKERGGPRWQNLMGTLGLSDAAWKGEIAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W6PX80</accession>
    <name>W6PX80_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S01g002197</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PX80"/>
    <dbReference type="OrthoDB" id="2942798at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM28386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="78" mass="9051" checksum="9CBFCC9B14115952" modified="2014-04-16" version="1">MSSSYIHDVAHHRQTLYDLAHNKIKVHEKNLETRLMEALKILYEHGAEHWDQKVDNLSFCDNASCDDGKVMVVDLEDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W6PX90</accession>
    <name>W6PX90_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">DASH complex subunit DUO1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Outer kinetochore protein DUO1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">PROQFM164_S01g002639</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DASH complex DUO1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PX90"/>
    <dbReference type="STRING" id="1365484.W6PX90"/>
    <dbReference type="OMA" id="QWQGASQ"/>
    <dbReference type="OrthoDB" id="5546837at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042729">
        <property type="term" value="C:DASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013960">
        <property type="entry name" value="DASH_Duo1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28216">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DUO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28216:SF1">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DUO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08651">
        <property type="entry name" value="DASH_Duo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="16" id="KW-0137">Centromere</keyword>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="10" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="8" id="KW-0493">Microtubule</keyword>
    <keyword evidence="9" id="KW-0498">Mitosis</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="174"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="184"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00044152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00044358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CDM28828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="243" mass="27090" checksum="33AE8EA7258191E9" modified="2014-04-16" version="1">MAFRTTAEEMERLQLSDDDTEDLWNSPSKRVTRKKINPRTSDEKPTLEPRASHDGEDPLFDHQQSRETALRTELQGVRNINEVIEGLLASLDSAKGNMETVSQTVTSASTLLNTWTRILSQTEHNQRLILNPDWQGATQDVIDIENQAIQRQQAAERREQALQQQREAAARKAEEIEKRRAQVTRGTRGTRGTTRGTFRTTGLGRTPSVSTSRTATRGSTTTTQRPASGIARGSGIARGRGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W6PXT7</accession>
    <name>W6PXT7_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cation efflux protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PROQFM164_S01g000583</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PXT7"/>
    <dbReference type="STRING" id="1365484.W6PXT7"/>
    <dbReference type="OMA" id="KWRANER"/>
    <dbReference type="OrthoDB" id="9944568at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027470">
        <property type="entry name" value="Cation_efflux_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45820:SF5">
        <property type="entry name" value="DIFFUSION FACILITATOR FAMILY METAL ION TRANSPORTER, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45820">
        <property type="entry name" value="FI23527P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16916">
        <property type="entry name" value="ZT_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="Cation efflux protein cytoplasmic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="79"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="213"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="240"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="9">
        <location>
            <begin position="13"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein cytoplasmic" evidence="10">
        <location>
            <begin position="304"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF16916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDM26774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="397" mass="43948" checksum="1BC19FBA83C4959D" modified="2014-04-16" version="1">MVLHLSRSTRLSVVIGISTCFFLAEISLGFYTHSIALIADAFHYLNDLVGFIIALVALKKSERSDSPKELTFGWQRAQLLGAFFNGVLLLGLGISIFLQSIERFIALQHIHDPKLMFIIGCIGLGLNIISVVFLHEHGHDHGHEHSHDHSLSPTIETPVLHLDEEYLDSSTKHDDHKHLHFEKHRCADSGGHSHGHGGHDHGDLGMMGVMIHVIGDAINNLGVMAAGLVIWLAAPYAGRYYADPGVSMFIAILIILSSFPMMRRAGMILLESVPTGVDMCDVKHDLEKVFPPFIFSFFIPNNRQIKGVNSIHELHIWRLNQQKTLASVHVVVSEDSVEDFMKTARVINECFHAYGIHSITLQPELSDAVDSQDGASQESSRCQVICGTLCERLTCCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W6PZ24</accession>
    <name>W6PZ24_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cytochrome c oxidase assembly protein PET191</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S01g003335</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PET191 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PZ24"/>
    <dbReference type="STRING" id="1365484.W6PZ24"/>
    <dbReference type="OMA" id="FLECKRG"/>
    <dbReference type="OrthoDB" id="282149at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018793">
        <property type="entry name" value="Cyt_c_oxidase_assmbl_Pet191"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28627">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28627:SF1">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10203">
        <property type="entry name" value="Pet191_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="67"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM29523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="117" mass="12991" checksum="F0EA740B25875D5B" modified="2014-04-16" version="1">MPSSCNDIRRALAQCLQESDCIMVQRHTPRECLSSPLAEELPVKCQQLRKGFSECKRGLIDMRKRFRGNQPISVSKEMDGGQSTSGGQLYAGAPAYQTVKELSGDEVQMDPEKTRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W6PZ77</accession>
    <name>W6PZ77_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Amino acid transporter, transmembrane</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PROQFM164_S01g003385</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PZ77"/>
    <dbReference type="STRING" id="1365484.W6PZ77"/>
    <dbReference type="OMA" id="DSIHHQR"/>
    <dbReference type="OrthoDB" id="438545at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061459">
        <property type="term" value="F:L-arginine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005313">
        <property type="term" value="F:L-glutamate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005290">
        <property type="term" value="F:L-histidine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015189">
        <property type="term" value="F:L-lysine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015194">
        <property type="term" value="F:L-serine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005302">
        <property type="term" value="F:L-tyrosine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF678">
        <property type="entry name" value="VACUOLAR AMINO ACID TRANSPORTER 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="4" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="158"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="223"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="258"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="295"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="368"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="392"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="476"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="11">
        <location>
            <begin position="33"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="341"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="423"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="430"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDM29573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="502" mass="53966" checksum="4B6F11AF9ACBB130" modified="2014-04-16" version="1">MEEAALGVGPSGGHQNMLRRRAARARPGDVVGEASWASSVINLVNTIIGAGVLAMPLAISRMGIVLGVCVILWSAVTAGFGLYLQSLCAQYLDRGSASFFALSQLTYPNAAVVFDCAIAIKCFGVGVSYLIIIGDLMPGVTQGFVGSEPGYDFLVDRHFWVTFFMLIVIPISYLRRLDSLKYTSIAALVSMAYLVVLVVYKFVQGDTMKDRGPIRVGHWEGAVPTLSSLPVIVFAFTCHQNMFSILNEIGNNSHFRTTAVVIASAGSAAATYILVAITGYLSFGNSVGGNIVGMYPPGVYATIGRAAIVMLVVFSYPLQCHPCRASVDAVLKWRPRAQVAGAESSPNRHPLLGPRGNRTPEPMSDLRFSIITTTILILSYLVAMTVSSLESVLAYVGSTGSTSISFILPGLFYYKISSPDSPTHQGLMKEDDEAEDDLSGDDDGDDGEGSLARPLTESGLLHRGTRHWRKALLRRLSLALALYGLVVMVVCLVTNTFFKISH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W6PZ80</accession>
    <name>W6PZ80_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S01g003137</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PZ80"/>
    <dbReference type="STRING" id="1365484.W6PZ80"/>
    <dbReference type="OrthoDB" id="2730545at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM29325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="90" mass="10555" checksum="056B28038AD7D37D" modified="2014-04-16" version="1">MLPIHLTCQISNLYDYVPALKERSFAERMKYQHRQFHFDGLAGMRTGTIPFRKHERVTRDALLQGQYELRECSAFHDNEDLLDTGRGISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q163</accession>
    <name>W6Q163_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="7">UDP-glucuronosyl/UDP-glucosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PROQFM164_S01g003523</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q163"/>
    <dbReference type="STRING" id="1365484.W6Q163"/>
    <dbReference type="OMA" id="CWKSCFE"/>
    <dbReference type="OrthoDB" id="5835829at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016906">
        <property type="term" value="F:sterol 3-beta-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000100">
        <property type="entry name" value="Glycosyltransferase family 1 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000009">
        <property type="entry name" value="Sterol 3-beta-glucosyltransferase UGT80A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010610">
        <property type="entry name" value="EryCIII-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050426">
        <property type="entry name" value="Glycosyltransferase_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004276">
        <property type="entry name" value="GlycoTrans_28_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48050">
        <property type="entry name" value="STEROL 3-BETA-GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48050:SF13">
        <property type="entry name" value="STEROL 3-BETA-GLUCOSYLTRANSFERASE UGT80A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06722">
        <property type="entry name" value="EryCIII-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03033">
        <property type="entry name" value="Glyco_transf_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyltransferase family 28 N-terminal" evidence="5">
        <location>
            <begin position="109"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="Erythromycin biosynthesis protein CIII-like C-terminal" evidence="6">
        <location>
            <begin position="430"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="16"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="653"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="692"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="692"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="710"/>
            <end position="729"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF06722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM29711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="940" mass="104186" checksum="D8A270AF39C328FB" modified="2014-04-16" version="1">MATVLAPNPAEISLERMDINRSGGWSSEDTKRASDDPDGVQFFEDGLNARILGDGRVDIHIDQHKAHLGGLLKHIQRADIHSERDSECAVSAERPYTNDEHFPLHLNLVIQVIGSRGDIQPFVALGRELKAHGHRVRLATHLAFRQFVLDSGLEFFNIGGDPEELMAYMVKNPGLLPGFKAIRSGDIQRRRREMKEIFNGCWKSCFEKGDGTYLHQIKEDPFSKTVDYRQRPFVADAIIANPPSLAHIHCARRLGIPLHIIFTMPWSPTQSFPHPLANVHRRNCKPTFANFVSYNIVDMMVWEGLGDILNTLRKNTLALQPLDTMTAPSILHRLHVPHTYMWSPSLLPKPPDWADNIDVCGFGFLLSETSYTPPTEIAAFLDAGPKPIYIGFGSIVVDNPTKLTKTIFEAVKNSGQRALISKGWGNLGADEVPDNILMIGNCPHDWLFRQVSCVIHHGGAGTTAAGLALGRPTIIVPFFGDQQFWGNIVARAGAGPAPIPHKNLNVQNLSNAIAKALEPSTLERAQTIALKMQEESGVRHGVNSFHRNLDPQSYRCSIVPNQPAAWHLKHTKINLSAFAATVLVRSGKISPDMLVLYRPIDAQVLFGVITSFVTGLVDAPREIVHDIVSAARSIRQPHEHFDRHAACRAVLSSPDHLSPENSDGTEETQIQNENEQLQIENEEQRDGEILEGESAQEDTTDADNETDVNSIDRIRSTERKRNIQLEKAKTMSSSMTPTNPPKFTILHEAALHGSQMSKKLLKIIIVVPTDLSLSMARGFHNAPKLYNDTTVTDIPQVVNLRSGFRAAGKEFRDGFYFGIKGLGTQPHRGLKHGGAKGLLKGIGKGIGGLFLKPTAGLWGLAGYPLSGIVREINDSLGRHQKCMIVMGRISQGLEEMRESTAQEREEVSKGWITIEHDLKKLKTHRHLHMSDSTHAVVLFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q1G0</accession>
    <name>W6Q1G0_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S02g000527</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q1G0"/>
    <dbReference type="STRING" id="1365484.W6Q1G0"/>
    <dbReference type="OMA" id="WNGATEH"/>
    <dbReference type="OrthoDB" id="5377172at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053143">
        <property type="entry name" value="Arylsulfate_ST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039535">
        <property type="entry name" value="ASST-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35340:SF6">
        <property type="entry name" value="ASST-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35340">
        <property type="entry name" value="PQQ ENZYME REPEAT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14269">
        <property type="entry name" value="Arylsulfotran_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004879318" evidence="1">
        <location>
            <begin position="21"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM30378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="505" mass="56108" checksum="0790635854603B93" modified="2014-04-16" version="1">MRLSSAFAALCGLQATLVVAENTTWPWRTFKSSPHQPPSLQISKSGPTSPGYLFFDQSWNAHQYGVFIMSDSNELVWQSPPGDLQDFRVQKLDGKPVLTYFNGLGVPEPFGWGYGIVQVLDESYRSIYNVSVTNDNYKALGSIDSSSFVSWIDIHENTMTSDGTMLVTGYNVTQADLSSVGGPKNGWIADSLFYEIDVKTNEILFRWSALDHINQIPLEHVQPFYPVRDWGHNSSSPYGYFHINSVDKFQDGTYLISSRYYCSLFKIAKDGSVDWTLQGQGGGDFELKGIKFSYQHDARIRDETENALILSIFDNSNSDVQNGTDHTEGIFMSVNLATREVSPVRTLHDQRDEIFSTSQGNTQLLPANHVVMGYGSNPKIKEYNANGSCIMTAQFGFDGVVSSYRAYRSPWVGVPATPPDVFSCIEKSSNKTNVYMSWNGATEHQQWKVFGGATRSELSPVAMARKTGFETVASIKGYLGYVRVEAHGLGIQKGVSKIVPVQSQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q1H3</accession>
    <name>W6Q1H3_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Aspartate/other aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PROQFM164_S02g000324</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q1H3"/>
    <dbReference type="STRING" id="1365484.W6Q1H3"/>
    <dbReference type="OMA" id="PTWGNYK"/>
    <dbReference type="OrthoDB" id="6752799at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004069">
        <property type="term" value="F:L-aspartate:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000796">
        <property type="entry name" value="Asp_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006719">
        <property type="entry name" value="PRK09257.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879:SF55">
        <property type="entry name" value="GLUTAMATE OXALOACETATE TRANSAMINASE 1, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00799">
        <property type="entry name" value="TRANSAMINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="7">
        <location>
            <begin position="27"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM30175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="402" mass="44637" checksum="65D5AB5090D2468E" modified="2014-04-16" version="1">MFDNIPPGPADPFFHLKKKADEDDHPDKVDIGVGIYRSEQGTYQELAVVKRAKKILEQLELGHDYGLTTGDDRFLKLAAEVMFGQENEALVSGRIASVQTLSGTGANHTAAVLIARLLDPKPAIYLGVPTWNNMKPLCEYAGLETIEYPYLDRETSELSFQPCIDAIRSAPTGSVFVLQGCCHNPTGKDITLDQWQRFGEEIKARGHLAFIDIAYQGLGDGLDEDAAGVRILSRLGIDMIVCQSFSKNFALYGERCGVLHVVTRSVEAATNTKDQLRSLIRREYSSSPAYGSRLVTIVLEDPELRQQWVDELASMRARLIQNRQRLYKELSTILQTPGDWKHIVEEKGLFSCLAITPAQCNALNDNYHVHLPVSGRINVAGLNNNNIERTARAIDAVVQGNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q243</accession>
    <name>W6Q243_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S02g000519</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">FM164</strain>
        </source>
    </reference>
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    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048315">
        <property type="term" value="P:conidium formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0075306">
        <property type="term" value="P:regulation of conidium formation"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:sexual sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Adenylate-forming_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33927:SF3">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN TMPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33927">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="231"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="272"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM30370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="510" mass="57037" checksum="A306D44F8F5F1832" modified="2014-04-16" version="1">MTDAEKNDLCMPVPPAKAIVIDHDMAITPDPEKFIGNYSSNEVPSNGPDSPNVVDLEAQPTEPRRKRFAHFRYVMFTVYRRLFTVVFCANLAVFLYVMISDRKLLALVNATAVNLVACGLARHPMMVNAIYRVVCSIPRKAPLSLRRRCAKAAHYGGVHSGCGTASLVWYIGFVAMVSQIYWTNSPISTVTDASFSAAPIAVAYVILALLVVMVVVAYPTFRRRMHDYFELTHRFTSWLILALFVALVMLFAHDVGNAEQQTLGYTLVTLPAFWLLIAAVFAVAHPWLLLRRVPVKAEPLSSHAVRLSFDFTPINFAKGVQVSKHPLRDWHSFAGFPDPIPTGEKPFVKGHRHKRSWSIVVSKAGDWTADTIREPPTHLWKRGALMRGVGYGLRVFDRIIIVTTGSGIGPCLGFLGDENRPLIKVIWQTRNPVKTYGQDVIDLVHKMGPDPIIFDTSRDGRVDMLPIVRQQVKEFKAEAVFVISNPKMTQDIVYEFESQGIPAYGPIFDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q2B8</accession>
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        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
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                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
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                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM28339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="167" mass="19261" checksum="B49A3D3E949F707C" modified="2014-04-16" version="1">MGLPPLDSDIKLLAIKRDIRHSGTSSIYEINLGSNRYAMKLFHDENGDPGFADNGRDLNRFRCEYNAYTNLLNFDVCESGLVPRCYGYIDRLDPSSFRPHLDHFLTDEMHPRAIILEYLEGAEELNCVNYSEERLQLAIQGMKEIHRALINHHDVYPKNILIVPSRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q305</accession>
    <name>W6Q305_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">PROQFM164_S02g001103</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30953.1"/>
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    </dbReference>
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    </dbReference>
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            <end position="72"/>
        </location>
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            <end position="252"/>
        </location>
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            <begin position="321"/>
            <end position="349"/>
        </location>
    </feature>
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        <location>
            <begin position="380"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="380"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM30953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="407" mass="44461" checksum="B08C16744F54B9B8" modified="2014-04-16" version="1">MLALRDQENLVNTHQTAAAAKPLNQSKPLAPKTPGKARNDENNPLAFGNRTVKGNGNRQDNGKPGNNAFMTPMVRDRAPLGMKTTNLKANNLQTPAPFGGTKQPRTNRRQSTAQKIRKAAPVTQQAQAKVHIDAAADDVPDIEYMPPKPRDLPDLPDDVTYDTTFPQFQPKNRALGLESVYGKQQVGSDGLTAKQRKFQEDSAACDRMVNDMIMKQLDDIGFESSGENESTKTLEPNAIPSKRPTTTTRHTRNVSTLRARDAVAALGGSRPTVAPRVAPIPKPRVASLASSLVMPKRHARVPSNPSSMRNTAAVVNSRTTVGYSKGRNVSSTLRDNHSQTQKPSSSQVLSPETYMQLYGPPPLDSEMWTRCNAAGCFDAPDEITQEPEEPLPTFDEDDEAQSFQLTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q355</accession>
    <name>W6Q355_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="6">AMP-dependent synthetase/ligase</fullName>
        </submittedName>
    </protein>
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        <name evidence="6" type="ORF">PROQFM164_S01g002440</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
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        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the NRP synthetase family.</text>
    </comment>
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        <property type="protein sequence ID" value="CDM28629.1"/>
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    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043041">
        <property type="term" value="P:amino acid activation for nonribosomal peptide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19537">
        <property type="entry name" value="C_NRPS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="Condensation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527:SF11">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHETASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="111"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="1064"/>
            <end position="1142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDM28629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="1610" mass="178020" checksum="4C3E6DA192DA43FB" modified="2014-04-16" version="1">MFNNGGPIRGFLVNLAQDVDAKVLQLNNRLSFSFSLLLNGHLVSIVVSGTIDTTSLLARWKMNAPVYMVPDHILVLESLPMMNGKTDFKALKAIIKESIGSTIEDPISATSTLSEAVMTALSQVADILIDQIDVNQSAISYGINSLAAIKVSSLCRQYGFTVPVRDILLEPSIQALIGRCDGQRSHVSTQETSLQCRKKSKITPLQKALLLATMDNHQMNYVQQLSHYATADIHRVKKAWEAVVSVEPMFRTSFSWSTEEPMQIVQPQASFAWEETTVKSQHDVDVAFQELISRADLGIDGFSASLIFQKVDAALEGRPFESSLPFTIAARDMEQLRRETRTEIQEHWSDREPLIPDACGDIASPNASLLSPRQPGHAQISVYESVDRAKVVEYACAVNVTPAAIFNAAWILLLTTYTNSDTIVYGSVFSGRNLPFSWADTMIGPLIQTLPVLVRVDRSSSTEKFLQQIHREIQGLASIHVSEVPSNIPAFSTTVAVQDGGLRRGTTAVKCLQDPSFQNTADIPLNLVIDPDEGIRLFYRTDMFSLTQVQDMADIYDSILHSLIRSRFSVQQCLGLKFPAHMREKILTAGNSNSTSSFTCNSGQTISSLFQYSTWHNASEISIQAGEKALTYTQLAERVDKITSVITLLVPAGAVIAVLADRSSNWIVGMLAAMQANTVYCPVDASYPEEYRAQLLERSGAQVLLLPNTSQMEKTGPNGPLTLAIDHILNKNIKPADFQPRLPQPSSTAYLCFTSGSTGQPKGVLCRHRGVVALYSSVSARPTSRPSTRIGQMLSPGFDGCIHEILSTVCSGGTLVLPRGKDDKFSHLSDVDVATLTPSLAAELDPRDYPNLKSIHFGGEPVPDALVERWASDRELYNIYGPTEVLWPILSINLNNQPMLTIGEIYIAGVQISRGYLGIEKKTTEEIVPDPFCEGFGQEMMYRSGDIGFLDEHGNLHCCGRDDRQVKLRGYRINLDDIPAVVYRTMCSVSKAVAVTENGAVVLWVEPEIDTELLRRQLAVALPPHSAPKSVYSMTKLPLTKNGKFDIKGLVSNNHVKLVPKSSQPLNSLEETLAGIWRQLLTLDSKRQISSADDFAVLGGHSLLQLALAARIKSLFNIPITVKDIISASTLRDLARLIQTQGESQVHGTPLASPEAQVQPLGLETPSSTEIEWIHCYQHSETTTSFNVPYFAELSTDVDIQKLASALQIVFNRHRILRSRFTSRGDKTLRSITGESIIVPVVRKVDVGHYINTPFNLDKESPIRAVVSQNQFVICASHVVCDLTSFNVILRETAAVYYGRKLEPVRREYFDCTVWNQPVGSDKLSFWSTYLKGLPITDGRAPDSPTEDPSCRSYHGESVFQTIPPPLYKSLLATSSLKGITLHQFGLAVVGIVLQTICGRHDVLLGSPYMNRSNTRDMEVVGLFLQPLPVRILLEKADSTTENALEEVRSSSQSALANAIPWSSLLNHLGLPFPSHQILRQRQQQPLFDCVVTFHDQRTHGNVENPFPVKGVKPVQISTEGSKFSCLFEWQADDCGLRIRYEYDTDALPTTIIDVVKSLVLRCLERMLDNKVLMRDLRSEIEDLFGAECHRQGLLRADVQRLGRAFLMGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q3D8</accession>
    <name>W6Q3D8_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RNA polymerase II holoenzyme cyclin-like subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">ssn8</name>
        <name evidence="14" type="ORF">PROQFM164_S02g001268</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. The SRB8-11 complex phosphorylates the C-terminal domain (CTD) of the largest subunit of RNA polymerase II.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the SRB8-11 complex, a regulatory module of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cyclin family. Cyclin C subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q3D8"/>
    <dbReference type="STRING" id="1365484.W6Q3D8"/>
    <dbReference type="OMA" id="CLLHPPH"/>
    <dbReference type="OrthoDB" id="10266018at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20513">
        <property type="entry name" value="CYCLIN_CCNC_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000092">
        <property type="entry name" value="RNA polymerase II holoenzyme cyclin-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043198">
        <property type="entry name" value="Cyclin/Ssn8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10026">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028758">
        <property type="entry name" value="Cyclin, C/H/G types"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="7 12" id="KW-0195">Cyclin</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0678">Repressor</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Cyclin-like" evidence="13">
        <location>
            <begin position="53"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDM31118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="304" mass="34449" checksum="81FDD8F8D4719633" modified="2014-04-16" version="1">MAANYWASSQRRHWLFSREKLADIREGLREKDKVAHSQFPLPDQRLLNIYFNQQLIKLGKRMSTRQQAIATAQVYLKRFYTKNEIRQTSPYLVLTTAFYLACKMEECPQHIRFVVGEARGLWPEFITPDVAKLGECEFALISELSSQLIVHHPYRTLSELQTELSLTSDEVALAWSVINDHYLTDLPLLHPPHVIAIMAIIVAVVFKPTHSSNYPGTGQSALAGSMRDGGGMQMLAALSDKTGSGPPPKIQKLVSWLAEGEVDIKAVIECTQELVSLYEVWEQYSEKNCKELLGRMVKSKNLDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q4T0</accession>
    <name>W6Q4T0_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">LSM complex subunit LSM3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">lsm3</name>
        <name evidence="10" type="synonym">LSM3</name>
        <name evidence="12" type="ORF">PROQFM164_S02g001126</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Binds specifically to the 3'-terminal U-tract of U6 snRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the heptameric LSM1-LSM7 complex, which consists of LSM1, LSM2, LSM3, LSM4, LSM5, LSM6 and LSM7. Component of the heptameric LSM2-LSM8 complex, which consists of LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8. The LSm subunits form a seven-membered ring structure with a doughnut shape.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">LSm subunits form a heteromer with a doughnut shape.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q4T0"/>
    <dbReference type="STRING" id="1365484.W6Q4T0"/>
    <dbReference type="OMA" id="FDSHCNI"/>
    <dbReference type="OrthoDB" id="29543at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01730">
        <property type="entry name" value="LSm3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000036">
        <property type="entry name" value="U6 snRNA-associated Sm-like protein LSm3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034105">
        <property type="entry name" value="Lsm3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040002">
        <property type="entry name" value="Sm-like_LSM3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13110">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 10" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 10" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="11">
        <location>
            <begin position="14"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDM30976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="96" mass="10833" checksum="A0E6B4A6AEF24C16" modified="2014-04-16" version="1">MADNEDTGGPSVSEPLDLVRLSLDETVFVKLRGDRELKGRLHAYDSHCNLVLGDVEETIYVVEEDENEEETLRTIKKQEEMLFVRGDSVVLISPQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q527</accession>
    <name>W6Q527_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AMP-dependent synthetase/ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PROQFM164_S01g003086</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q527"/>
    <dbReference type="STRING" id="1365484.W6Q527"/>
    <dbReference type="OMA" id="ICCRGYN"/>
    <dbReference type="OrthoDB" id="10253115at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031956">
        <property type="term" value="F:medium-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05917">
        <property type="entry name" value="FACL_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000008">
        <property type="entry name" value="2,3-dihydroxybenzoate-AMP ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201">
        <property type="entry name" value="ACYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201:SF30">
        <property type="entry name" value="AMP-DEPENDENT SYNTHETASE_LIGASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="65"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="4">
        <location>
            <begin position="518"/>
            <end position="598"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDM29274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="617" mass="66805" checksum="D3C289520B9EDBBC" modified="2014-04-16" version="1">MSYSGIITGLSRRGCTSCRKCVLGGKSVLQQASLVKRGLLTESYARGPSGPPLIESTVGDHFAKIVAECGDRTAVISRHQKDRATYASLDTRSNALARGLESLGVVKGERVGVMLGNSIEYAVATYALFKLGAVLVPLNPSFNTAQVIAALGHLGSGHLLISTESNLPRKQPRSNVPLLNDIVEDLHKSNLESALVPSLKNIIMVDNSEGRVDISSYKSLTPYASIVSQLTADGRPLPPQNLSPDETVNIQFTSGTTSMPKAACLTHRSILNNGSQIGDRMLLTPNDIVCCPPPLFHCFGGILGYMATATHGSAIVFPSESFNARAALEAVQEEKCTALHGVPTMFLEELSMIEMGEISKEGFQYLRTGIAAGSSIPSEIMKKLHKVLNLTELTICYGMTETSPVSAMTTTDDPIDKRIYSVGKLMPHVEAKIVEPMDKKEILPIETRGELAVSGYLLMKEYWDDPEKTAQVMIPDESGKLWMHTGDEASMSSDGYITITGRIKDLIIRGGENIHPLEIENCLLANDSVADVSVVGVPDARYGEAVAAFVIPRDHGLKTVTAEDIQQWVREKLSNHLIPKYVFFLGPLEPFPKTASGKIQKFKLREKAIALLTKSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q555</accession>
    <name>W6Q555_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Glutathione S-transferase omega-like 2</fullName>
            <ecNumber evidence="3">1.8.5.1</ecNumber>
            <ecNumber evidence="4">2.5.1.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Glutathione-dependent dehydroascorbate reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">ECM4</name>
        <name evidence="18" type="ORF">PROQFM164_S02g001266</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Active as '1-Cys' thiol transferase against beta-hydroxyethyl disulfide (HED), as dehydroascorbate reductase and as dimethylarsinic acid reductase, while not active against the standard GST substrate 1-chloro-2,4-dinitrobenzene (CDNB). May be involved in cell wall organization and biogenesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-dehydroascorbate + 2 glutathione = glutathione disulfide + L-ascorbate</text>
            <dbReference type="Rhea" id="RHEA:24424"/>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58297"/>
            <dbReference type="ChEBI" id="CHEBI:58539"/>
            <dbReference type="EC" id="1.8.5.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GST superfamily. Omega family.</text>
    </comment>
    <dbReference type="EC" id="1.8.5.1" evidence="3"/>
    <dbReference type="EC" id="2.5.1.18" evidence="4"/>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q555"/>
    <dbReference type="STRING" id="1365484.W6Q555"/>
    <dbReference type="OMA" id="PWANRAI"/>
    <dbReference type="OrthoDB" id="2309723at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045174">
        <property type="term" value="F:glutathione dehydrogenase (ascorbate) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03190">
        <property type="entry name" value="GST_C_Omega_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000162">
        <property type="entry name" value="Glutathione S-transferase Gst3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.10:FF:000038">
        <property type="entry name" value="Glutathione S-transferase omega-like 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047047">
        <property type="entry name" value="GST_Omega-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016639">
        <property type="entry name" value="GST_Omega/GSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32419:SF6">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE OMEGA-LIKE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32419">
        <property type="entry name" value="GLUTATHIONYL-HYDROQUINONE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13410">
        <property type="entry name" value="GST_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015753">
        <property type="entry name" value="GST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01206">
        <property type="entry name" value="Xi.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01148">
        <property type="entry name" value="Xi_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 18" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST C-terminal" evidence="17">
        <location>
            <begin position="174"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="14">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="14">
        <location>
            <position position="197"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>glutathione</name>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="129"/>
            <end position="132"/>
        </location>
        <ligand>
            <name>glutathione</name>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="147"/>
            <end position="148"/>
        </location>
        <ligand>
            <name>glutathione</name>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Cys" evidence="16">
        <location>
            <position position="260"/>
        </location>
    </feature>
    <feature type="site" description="Lowers pKa of active site Cys" evidence="16">
        <location>
            <position position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00055859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00070045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR015753-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR015753-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR015753-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CDM31116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="340" mass="39598" checksum="00BE35544BC9170A" modified="2014-04-16" version="1">MATVNSMKITDWVKPGDKSGEFKRQQSIFRNWISREAGAQFPPEKGRYHLYVSYACPWAHRTLITRKLKGLEDIISFTSVHWHLGAEGWRFATPDEKLPGENTIPDPLHPDFTHIRQVYFSNDPDYSGRFTVPVLFDKKTKLIVSNESSEIIRMLYHEFDDLLPEEYKKIDLFPKALQAEIEASNDWIYNDINNGVYKSGFATTQEAYEKAVTTLFSSLDKVEDHLAKQQAASKPYFFGDKITEADIRLYTTIVRFDPVYVQHFKCNLRDIRSGFPAIHRWVRKLYWEIPAFRDTTDFEHIKFHYTKSHKQINQFAITPLGPVPDILPQDEEVRAVQAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q579</accession>
    <name>W6Q579_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Major facilitator superfamily domain, general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S02g001655</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q579"/>
    <dbReference type="OrthoDB" id="194139at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM31505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="210" mass="22778" checksum="51BE89D2CD3CA883" modified="2014-04-16" version="1">MRIENHDRGNENAPLLESSFTPSPVQKPRLATFLLSLCIFFLSGGSAMIQVRSFYLSYSLGYQSYFQNTCGQLSILGRASACLAIFGSFLTGAPRIGLVIFGLILQTSGAGLNAICRSIAMSYMGAHDKSKMNAMIGIFETFGSMFAGSTLAWLFSQGMKLRGIWFGLPYYGLAAFSGLCLAGLFFLGPSQHQDLNDIDEPQRSTASDLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q5B6</accession>
    <name>W6Q5B6_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative voltage-gated potassium channel subunit beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PROQFM164_S01g003196</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the shaker potassium channel beta subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q5B6"/>
    <dbReference type="STRING" id="1365484.W6Q5B6"/>
    <dbReference type="OMA" id="MWAGPYG"/>
    <dbReference type="OrthoDB" id="1720422at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034220">
        <property type="term" value="P:monoatomic ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19143">
        <property type="entry name" value="AKR_AKR6C1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005399">
        <property type="entry name" value="K_chnl_volt-dep_bsu_KCNAB-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43150">
        <property type="entry name" value="HYPERKINETIC, ISOFORM M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43150:SF6">
        <property type="entry name" value="VIC POTASSIUM ION CHANNEL, BETA SUBUNIT (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01577">
        <property type="entry name" value="KCNABCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="4">
        <location>
            <begin position="23"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDM29384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="349" mass="38878" checksum="FBF0F2867A385B0D" modified="2014-04-16" version="1">MSDALPEMQYRSLGRTGLKVSVISLGSWLTYGGHVGNETALECMKVAYDAGVNFFDTAEVYSGGKSEIVLGEAIKKFGWKQNDLVISTKIYWGRANSANPDKPLNNNGLSRKHIIEGMNHSLQRLDLPYVDVVYAHRADRDTPMEEIVRGFNYLIDNGKAFYWGTSEWTASEIADAWRIADRLGLVGPVVEQPQYNLLVRERVEKEYRWLYEAHGLGLTVWSPLKGGVLTGKYNDVAAPPAGSRLAESEDKYVQGLRKTVGDDTWQRQLDQVAALKPIAEELGVTTAQLALAWVLKNPNISSMITGASRPQQVLENIRALEVVEKLTDEVIEKIEIAVGNKPAVEVRRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q5C4</accession>
    <name>W6Q5C4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PROQFM164_S01g003206</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q5C4"/>
    <dbReference type="STRING" id="1365484.W6Q5C4"/>
    <dbReference type="OrthoDB" id="424974at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF77">
        <property type="entry name" value="TRANSCRIPTION FACTOR, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12940)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDM29394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="157" mass="18013" checksum="3A44BB8EB0CD4732" modified="2014-04-16" version="1">MDVVQVELHRRLWAQICYLDFRAAEDQGFAPSIHESDFDTRRPLSLDEVDLIEGVEPSSGLSDAPKFTDMTIYLLRITTVQYYRRIIQVTHASRKKLRISSPVDAAEALVELQSLLSTAQTLASEFERNLDDLVRYCDKRVSIQSMALDLRNHLKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q5K0</accession>
    <name>W6Q5K0_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL5m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PROQFM164_S01g003306</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL5 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q5K0"/>
    <dbReference type="STRING" id="1365484.W6Q5K0"/>
    <dbReference type="OMA" id="HITIHTT"/>
    <dbReference type="OrthoDB" id="539541at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1440.10:FF:000001">
        <property type="entry name" value="50S ribosomal protein L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002132">
        <property type="entry name" value="Ribosomal_uL5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031309">
        <property type="entry name" value="Ribosomal_uL5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022803">
        <property type="entry name" value="Ribosomal_uL5_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11994">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00673">
        <property type="entry name" value="Ribosomal_L5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55282">
        <property type="entry name" value="RL5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL5 C-terminal" evidence="6">
        <location>
            <begin position="252"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="45"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="50"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM29494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="356" mass="39458" checksum="E3C606FC866DBB2A" modified="2014-04-16" version="1">MAAREPCRYLTRALPRASVPSIRPQGFFSSRNVSDEAPARRLSDHLTELETASSLSTPVPDSAAASFDPLARASARKTQLPRGRYQFRSPKYNRGPLHPHQPPPPSDPSSRLFVPGPFSAPRAEQTFDSTVSPDIMTLCYVHTPPGFKPPPKSARLREWDDSSPYHKNRVLRGPRGGDVLRLLRKPIKFNNIPEIERITIHSYVKNAAAERNSSWLHVAGIAIQAISNVRVQTFKSKSNVAPWGIAANRDSVAVKAELYGENMYHFFGKLVDVVLPRIKDWEGVKGSSGDSSGNITFGLIPENVALFPELEVNYDMYPPKMIPGCHITLHTTAKTDKDARLLLSAMGIPFYGKIVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q5M7</accession>
    <name>W6Q5M7_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S02g001416</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q5M7"/>
    <dbReference type="OMA" id="HYLAPFS"/>
    <dbReference type="OrthoDB" id="10453044at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM31266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="93" mass="10299" checksum="50E1ACD2917C04A7" modified="2014-04-16" version="1">MAFTSLGKPGEDTEAVRSTGSVQNYVFSKYDHSVRWIPEGRRGRRYPPHPHYLAPFSRWLPSDSVVGGPGIRVGPVWVTPGTNPREIVGPRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q615</accession>
    <name>W6Q615_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">alcohol dehydrogenase</fullName>
            <ecNumber evidence="3">1.1.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PROQFM164_S02g001891</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM164</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.1" evidence="3"/>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q615"/>
    <dbReference type="STRING" id="1365484.W6Q615"/>
    <dbReference type="OMA" id="QWINSIC"/>
    <dbReference type="OrthoDB" id="1879366at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08297">
        <property type="entry name" value="CAD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000039">
        <property type="entry name" value="Alcohol dehydrogenase AdhP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940:SF3">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="9">
        <location>
            <begin position="17"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDM31740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="413" mass="44709" checksum="4986BEFB7ADCD0EA" modified="2014-04-16" version="1">MTDIPKRQWAQVFETSGSALHFTQVPVPVPGATEVLVNIKYSGVCHSDLQAWKGGWPLDPKKGLIGGHEGVGIVVKTGEGVEDLAVGDHVGIQWINSICGSCVSCDSNDQRSCASAQFSGYTRDGTFQQYVVCKELCAVRIPPEAPLDKIAPILCAGVTVYRALQETGAQAGDIVAIAGAGGGLGTLACQYAKAMGFRVLAISSGAEKRTHCEKLGVDYFADYKSSKDLTRDIQRLTNGGPHAVVVVSSDDRPISQAVEYIRSRGTIVLVGLPPGAVIKADLFSVVIRMITIKGSYVGTREDTEEALEFFLRKNLAMQCQIMELEQLPQVYDMMEKASIKGRIVLRMPESAGMTELFDRPSLMPPLITPSFSPKDHNIGTLLAHRMEELGVKDFFAVPGTCAKIPFEKRHHQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q6Q9</accession>
    <name>W6Q6Q9_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Spindle pole body component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">alp4</name>
        <name evidence="9" type="ORF">PROQFM164_S02g001832</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
            <location evidence="5">Cytoskeleton</location>
            <location evidence="5">Microtubule organizing center</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the TUBGCP family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q6Q9"/>
    <dbReference type="STRING" id="1365484.W6Q6Q9"/>
    <dbReference type="OMA" id="QNMSGDP"/>
    <dbReference type="OrthoDB" id="2192946at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051011">
        <property type="term" value="F:microtubule minus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1900:FF:000011">
        <property type="entry name" value="Spindle pole body component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1900">
        <property type="entry name" value="Gamma-tubulin complex, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007259">
        <property type="entry name" value="GCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040457">
        <property type="entry name" value="GCP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042241">
        <property type="entry name" value="GCP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041470">
        <property type="entry name" value="GCP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302:SF13">
        <property type="entry name" value="GAMMA-TUBULIN COMPLEX COMPONENT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04130">
        <property type="entry name" value="GCP_C_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17681">
        <property type="entry name" value="GCP_N_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3 5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma tubulin complex component protein N-terminal" evidence="8">
        <location>
            <begin position="174"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="domain" description="Gamma tubulin complex component C-terminal" evidence="7">
        <location>
            <begin position="515"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="52"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM31681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="887" mass="100364" checksum="7FABC0B3D387D0A6" modified="2014-04-16" version="1">MSANDRAAYMNASRPRAVSNRVDSETRGASPLQIENKDPLRRSSSNQKHRASRDQKSMADKRSERMVITSRERAVRRNPVNPVKESINAASRGDWDKTRPRKPVQLDDGNSSFRTGEKDLADSPWNPQASLIPHSTAPLACRVSVPPLASTAPQALHPRPLRELSPDAQEAAILEDLLFVFMGFEGQYVHYASSYDPSIEKDRLTGPIFQIAPGLDPTLRDLIQSMLKMATHYSAMEAFVEIQSRAECGAVSHSLCASIRKLLKDYLILIAQLEGQLLNNPTFTLHLLHLYTMPTSQCLSQLYSMGQELLLKNGLLDEELEESTDDFDEDVDNILEQLKEGGDLVPGSMARKKMCKGGNILGLLTGRLASFSGDPITKTLLQTLLRDASRPYMAMLNEWLHHGGIRDPHAEFLVKEQKWIKREKLEEDYTDEYWEKRYTIRENEVPPQLKSVQDKVLLAGKYLNVVRECGGVDVSKEVKDVPKTLDDPRFLDNVNSAYTYANASLLNLLVTKNSLTTRFRSLKHYFFLDRSDFFSYFLELGASELRKPARAVNEGKLQSLLDIVLRQPGSVAALDPFKEDVKVRMNKIGLTKWLMQVVNVSGVNQEGAEAEKQQGSAVHSADEDKDILGFDALELDYSVPFPLSLVISRKTVLRYQLIFRHLLSLRHLETLLVTSWADQNKTISWRHKSSDRRLEIWKRRAWNLRAKMLVFVQQLLYFCTAEVIEPNWVGLMDRVNSVDADASEVEENYMKQVNRTVDELMQDHVDFLDTCLKECMLTQAKLLKIHSKLVTCCTMFASWTAASLSRALASADPDLAGGKVPGADARGYDPTRIGKLEDTLKRYEDHFSRHLRILMDSLNYFAATESVVLLKLAHSLTSISREESKED</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q780</accession>
    <name>W6Q780_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">E3 ubiquitin-protein ligase</fullName>
            <ecNumber evidence="9">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">hulA</name>
        <name evidence="16" type="ORF">PROQFM164_S02g000268</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 9">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RSP5/NEDD4 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="9"/>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q780"/>
    <dbReference type="STRING" id="1365484.W6Q780"/>
    <dbReference type="OMA" id="WKRPTLD"/>
    <dbReference type="OrthoDB" id="8068875at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd08382">
        <property type="entry name" value="C2_Smurf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.10:FF:000011">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.10:FF:000017">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.10:FF:000053">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000074">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1750.10:FF:000005">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2160.10:FF:000001">
        <property type="entry name" value="E3 ubiquitin-protein ligase NEDD4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2410.10:FF:000001">
        <property type="entry name" value="E3 ubiquitin-protein ligase NEDD4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024928">
        <property type="entry name" value="E3_ub_ligase_SMURF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050409">
        <property type="entry name" value="E3_ubiq-protein_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254:SF440">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE NEDD-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254">
        <property type="entry name" value="HECT DOMAIN UBIQUITIN-PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001569">
        <property type="entry name" value="E3_ub_ligase_SMURF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 9 11" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="C2" evidence="13">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="14">
        <location>
            <begin position="231"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="14">
        <location>
            <begin position="348"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="14">
        <location>
            <begin position="411"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="HECT" evidence="15">
        <location>
            <begin position="500"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="134"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="343"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="134"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="166"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="181"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="255"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="269"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="317"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="10 11">
        <location>
            <position position="801"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR001569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001569-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CDM30119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="833" mass="93512" checksum="FEB9363BDF208BA7" modified="2014-04-16" version="1">MASNLPAQPNLRVTIIAADGLYKRDVFRFPDPFAVATVGGEQTHTTSVIKKTLNPYWNEPFDLRVNEDSILAIQIFDQKKFKKKDQGFLGVINVRIGDVIDLSMGGDEMLTRDLKKSNDNLVVHGKLIINLSSNLTAPHPNQNGLQRQQAQSSTSSGLVPQVAAPTAQSQAGPNNTDTTPAAASSSSLPQRTPTTGPPAGAPPPSNGAPTNPPGPGAPSRANLSSFEDSQGRLPAGYERREDNLGRTYYVDHNTRTTTWSRPSANYNEHTQRSQREANMQLERRAHQSRMLPEDRTGANSPNLPDAQQAPTPPPGPNAGTSLATGAPAGSNAAAISMMATGATTAGTGELPPGWERRVTPEGRPYFVDHNTRTTTWVDPRRQQYIRMYGQGQTTGGANNTTIQQQPVSQLGPLPSGWEMRLTNTARVYFVDHNTKTTTWDDPRLPSSLDQGVPQYKRDFRRKLIYFRSQPALRIMSGQCHVKVRRNNIFEDSYAEIMRQSASDLKKRLMIKFDGEDGLDYGGLSREFFFLLSHEMFNPFYCLFEYSAHDNYTLQINPHSGVNPEHLNYFKFIGRVVGLAIFHRRFLDSFFIGAFYKMMLRKKVSLQDMEGVDEDLHRNLAWTLDNDIDGIVELTFSVDDEKFGERRTIDLIPGGRDIPVTNENKPQYIELVTEWKIMKRVEEQFDAFMSGFNELIPPDLVNVFDERELELLIGGIADIDVEDWKKHTDYRGYQEQDEVIQNFWKIVRTWDAEQKSRLLQFTTGTSRIPVNGFKDLQGSDGPRRFTIEKSGDPAALPKSHTCFNRLDLPPYKTHDALEHKMSIAVEETLGFGQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q813</accession>
    <name>W6Q813_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="8">CPL</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PROQFM164_S02g000533</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">RNA-binding nucleolar protein required for pre-rRNA processing. Involved in production of 18S rRNA and assembly of small ribosomal subunit.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q813"/>
    <dbReference type="STRING" id="1365484.W6Q813"/>
    <dbReference type="OMA" id="YGPEFSI"/>
    <dbReference type="OrthoDB" id="497380at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012959">
        <property type="entry name" value="CPL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033133">
        <property type="entry name" value="PUM-HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040059">
        <property type="entry name" value="PUM3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13389">
        <property type="entry name" value="PUMILIO HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13389:SF0">
        <property type="entry name" value="PUMILIO HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08144">
        <property type="entry name" value="CPL"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="PUM-HD" evidence="7">
        <location>
            <begin position="148"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="664"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="27"/>
            <end position="37"/>
        </location>
    </feature>
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        <location>
            <begin position="38"/>
            <end position="54"/>
        </location>
    </feature>
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            <begin position="62"/>
            <end position="96"/>
        </location>
    </feature>
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        <location>
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            <end position="116"/>
        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="674"/>
            <end position="687"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024893"/>
        </source>
    </evidence>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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            <dbReference type="PROSITE" id="PS50303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM30384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="687" mass="77586" checksum="063FDB98DB3B6DDE" modified="2014-04-16" version="1">MAGLKRAVDGSEERNGKRSKTKEGSASKSKSVKSSSSSKKDSKKDPKSSKSDKKPSKKVQMEESEDEDDFDIDDVSDEDIDALSDDAEMPDVSEEEEKPKSGRTLNAEERAQKEAPKNPNNSRESHLKQKALQLERKAAKPNADTVARSKKLWEQLRRKSHVPLEQRKKLVKELFEIITTRVRDFVFKHDSVRVIQTALKYGNLEQRKLIAHELKGTYKELAQSRYAKFLVGKLIVHGDDETRDLIIPEFYGHVRRLIRHPEGSWILDDIYRTVATRAQKARLLREWYGPEFVIFQDENETTSDLAKIIEAHPEKRGPIMNYLRELINQLVQKKSTGFTMLHDAMLQYFLCTKPGSNEANEFIELIKGDEEGDLIKNLAFTQSGSRLMCLMLAYSNAKDRKLLIRFFRDIVKAMAGDVYGHQVILAAYEVIDDTKLSAKSFFPELLNQNETEEARNEELCYQVNDLTARIAVLYPFAGERVKWLLPEADQTVLEEVREVRKETSKKDPAMRRQELVKAASPTLLEFIAARASTLLETTFGCQFLSEVLFEADGDKTAALAAVAEAAKSHTEARDTAHAGRLLKSLVQGGRFNPASKSIEKVEPALNFHDVLYAQIQDEILDWATGANPFVIVALAESEDFEKKSELLKTLKKNKKALEQASALVVEKDGKKKPSPSSSGAKLLLSKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q831</accession>
    <name>W6Q831_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S02g003014</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="4369355at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="18"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM32863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="166" mass="18245" checksum="91A5A613D9004802" modified="2014-04-16" version="1">MESGRPTREIIQPARPHASASASGNGQGSSSSAYHHRDCIVSRTVNLHSPYLPETPDPILGQVWIDHIDSMLGVRTERQTEEMRYCIEQTDRIVRLADNILKQQKELLACLRRMARGCDSDDSSTEISGLFEFSDSSIEQESDGDDIANGCSAVNGHMDGHGTADE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q844</accession>
    <name>W6Q844_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Succinyl-CoA synthetase, beta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PROQFM164_S02g003029</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM164</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1365484.W6Q844"/>
    <dbReference type="OMA" id="RFWFNLS"/>
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    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00999"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042709">
        <property type="term" value="C:succinate-CoA ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004775">
        <property type="term" value="F:succinate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006104">
        <property type="term" value="P:succinyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.261:FF:000001">
        <property type="entry name" value="Succinate--CoA ligase [ADP-forming] subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013650">
        <property type="entry name" value="ATP-grasp_succ-CoA_synth-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017866">
        <property type="entry name" value="Succ-CoA_synthase_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="SUCC_ACL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005809">
        <property type="entry name" value="Succ_CoA_ligase-like_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001913">
        <property type="entry name" value="PRK00696.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11815:SF1">
        <property type="entry name" value="SUCCINATE--COA LIGASE [ADP-FORMING] SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11815">
        <property type="entry name" value="SUCCINYL-COA SYNTHETASE BETA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08442">
        <property type="entry name" value="ATP-grasp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001554">
        <property type="entry name" value="SucCS_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01217">
        <property type="entry name" value="SUCCINYL_COA_LIG_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="2" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="ATP-grasp" evidence="10">
        <location>
            <begin position="33"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDM32878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="433" mass="47392" checksum="C608F95CE20913BE" modified="2014-04-16" version="1">MIAWRSIARTFQRHYAPLKAQVRQLSLLESHSHKLLQEFKLPVPPGFLVTTPEQAKHVVSVINGPSVIKAQVLAGGRGKGKFNSDGQSGVRHVESPTEAFKNAANMLGYYLTTAQTPADGLCVDKLYIVKAISIAQEFYFAMTFDRQQASPVLLISAAGGTNIESNIDKLHKLRFGLSTGITDEIDEYLQAELGFSDSEMGDIHQILVQMFKLFKEKDATLLELNPLVRTEDGEFVCLDAKFGFDNAASYRQPGLFAMEERAPEQEEEHRLAELGLNYVRLEGNIGNIVNGAGLAMATNDLISLYGGKCANFLDVGGAATKEALAKAFEVLKNDERVKGILINIYGGIVRCDMIAEAIIAAAAEMGGFKCPVVVRLQGTNSEKGLELVSNLFVVESWLIPLQVERSGLDNLIVEAEFEKAAQLIVEQTPRVES</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q8W1</accession>
    <name>W6Q8W1_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Isopenicillin N synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S02g000809</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q8W1"/>
    <dbReference type="STRING" id="1365484.W6Q8W1"/>
    <dbReference type="OMA" id="FWHVGRE"/>
    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044283">
        <property type="term" value="P:small molecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.330:FF:000030">
        <property type="entry name" value="Thymine dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00682">
        <property type="entry name" value="IPNSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="3">
        <location>
            <begin position="194"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM30659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="350" mass="38439" checksum="FDE51B4DBD505C9C" modified="2014-04-16" version="1">MTSNTPDNQASAAVDKDDLKIPLIDFGPFFTGTPSDKHAVALSITEAFKTSGFLYLKAHGIPPSVVSGVFASSARFFARPQSEKDSLGWTTPQSNRGYVAIGREKLTTVDETTGVDTLRASAPDIKETMELGREGVEGLPNRWPDHLDDEGKDFKKTMQSFFEMGKTLHKHIMQAIALGMNLPEHFFDDSVNAGDNNLRLLHYPSVSKEVFKNNPNQVRAGEHSDYGSITLLFQDRHGGLQVRSPKGTFVDATPIADAIVVNAGDLLARWSNDTIKSTRHRVIQPPVPEGSGDDASDYPARYSIAYFCQPNNDKLIEALPGTFGEEIQVAKKYSPITSGDYLVQRLTATY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q945</accession>
    <name>W6Q945_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Serine/threonine-protein kinase RAD53</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PROQFM164_S02g003345</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CHEK2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM33193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q945"/>
    <dbReference type="STRING" id="1365484.W6Q945"/>
    <dbReference type="OMA" id="DTRIPAY"/>
    <dbReference type="OrthoDB" id="504170at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05117">
        <property type="entry name" value="STKc_CAMK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000861">
        <property type="entry name" value="Serine/threonine-protein kinase RAD53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.20:FF:000065">
        <property type="entry name" value="Serine/threonine-protein kinase RAD53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000470">
        <property type="entry name" value="Serine/threonine-protein kinase RAD53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030616">
        <property type="entry name" value="Aur-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24350">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE IAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 8 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FHA" evidence="12">
        <location>
            <begin position="91"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="238"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="694"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="725"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="779"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="362"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="267"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="382"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)" evidence="9">
        <location>
            <position position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDM33193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="1033" mass="115042" checksum="1677D8ED2C0AFA59" modified="2014-04-16" version="1">MEATQESTQPCADPRRMGMNNSGIQDQDLADIICILHPNSHAAHDAVSATGGICPQHILQRDILGHDSSHTASLDLALRLSSKVHNLGLGFCFGRNRSRCDILLSVDDNAKRVSNNHFRIYLTEDGILMLQDTSTNGTIVDNCRLRKSQKDGNSRMLTNGSVIQVVTGCQNSDEVRFVVRIPLREGFAVHYHQNLFRYFERVHAHAPAHKERQGPSPSALAWSSANAYGMHWTGGAMYNVTGQIGKGAFATVYKIATKQHGAIYAAKELDKRRFMKNGILDQKVDNEMKIMRDLRHPNIVQYIDHHEHDRWIYIIMEYVPGGELSTYLHTQERIPEEMVRTIARQVLRALHYLHKRHITHRDIKPDNILIASLDPLRIKLSDFGLSKVVEQETFLKTFCGTLLYCAPEVYPDYDQYRRGELRKRRRVGDPPPRTSPYSQSVDMWSLGAVLFHILAGVPPFSGRAEDRGLQMLRTIMTSDADFDALRTAGVSEAGIDFVAQLLNRDPFSRPTEKKCFQHPWISEVPDVDEYEDDDDLLYDYQDRLSIIGEDPEDELDASQLSIADGPGYVHEADGEESSGSEAISKRPRTQYIPTDVHYPSLPNIESFQDGQAVVDNSAKRLFGEITPSALRSSHALGNIQAFNANNFHVDFLSSGESMMSDDPNESIISLPAVPFGGTAPSLMGAEKLVGQLNMNSLNPTPQLKGGPVNRSSLRQTPPGHTKGETLSSSPKKDSLPPTSSPKAESVSSPQEATPKAKFTRRIDLTLAIPDTASEASSDNSDHNSHRDTTPNYPSRPSKSEYDVEFATTLDAQTGQAILDRVCVEEADSSEPIVHRPNSPPIPSTLYDPEFAKPPKRYGKLKSLPGSIFDLTIYLEDRLTSWGRGPSATVKHADSMDTRIPAYALEVTFWTPGIEARIATGESWLDIPGVMAILSTKARLGIWVNDTLLRRGSMTEDGPEALQFGKLYTGDIITVYQNKDRTKFLKLQCEFTHGESAQPRPGPEAGFMVRQALMSKADRTTNRMPIQSQCKDRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q997</accession>
    <name>W6Q997_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATPase, F1 complex, epsilon subunit, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g000131</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ATPase epsilon family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q997"/>
    <dbReference type="STRING" id="1365484.W6Q997"/>
    <dbReference type="OMA" id="NKYTQIA"/>
    <dbReference type="OrthoDB" id="269124at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042776">
        <property type="term" value="P:proton motive force-driven mitochondrial ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12153">
        <property type="entry name" value="F1-ATPase_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1620.20:FF:000003">
        <property type="entry name" value="Mitochondrial ATP synthase epsilon chain domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1620.20">
        <property type="entry name" value="ATP synthase, F1 complex, epsilon subunit superfamily, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006721">
        <property type="entry name" value="ATP_synth_F1_esu_mt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036742">
        <property type="entry name" value="ATP_synth_F1_esu_sf_mt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12448">
        <property type="entry name" value="ATP SYNTHASE EPSILON CHAIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12448:SF0">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT EPSILON, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04627">
        <property type="entry name" value="ATP-synt_Eps"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48690">
        <property type="entry name" value="Epsilon subunit of mitochondrial F1F0-ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM26322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="73" mass="8091" checksum="86CB401971174326" modified="2014-04-16" version="1">MTAAWKAAGLTYNRYLAIAARTVRRSLKEAPRLASERRGVMDLRFAKWDNGKQGEVKSLAQANNEAIAKAAEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W6QAC3</accession>
    <name>W6QAC3_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Xanthine phosphoribosyltransferase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">XPT1</name>
        <name evidence="4" type="ORF">PROQFM164_S01g000541</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QAC3"/>
    <dbReference type="STRING" id="1365484.W6QAC3"/>
    <dbReference type="OMA" id="TYNDVHN"/>
    <dbReference type="OrthoDB" id="9973266at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004422">
        <property type="term" value="F:hypoxanthine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032263">
        <property type="term" value="P:GMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046100">
        <property type="term" value="P:hypoxanthine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032264">
        <property type="term" value="P:IMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032265">
        <property type="term" value="P:XMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000033">
        <property type="entry name" value="Xanthine phosphoribosyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43363">
        <property type="entry name" value="HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43363:SF1">
        <property type="entry name" value="HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="3">
        <location>
            <begin position="11"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM26732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="233" mass="26142" checksum="ABFDC3D8160065CF" modified="2014-04-16" version="1">MSENKQYATYNDVHNLCKNSAKEPLANWDINLIIAIGGGGYIPARILRSFLKKPGQSNIPIQAIGLSLYEKLGTDSVEEVPGTKVTRLQWLDMNSSMANLIGKNVLIVDEVDDTRTTLQYAVNELEEDVKKAQKQLPANDPRKDKETKFFVFVLHNKKKPKKGELPTDMTDNDQRYHAAVTTGDVWICYPWEAENIEEHDSQAKLSPIVNIPQKHVEEASTEAVQGEPSPQVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>W6QAH8</accession>
    <name>W6QAH8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="16">DNA repair protein (XPGC)/yeast Rad</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PROQFM164_S03g000144</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Single-stranded DNA endonuclease involved in excision repair of DNA damaged with UV light, bulky adducts, or cross-linking agents. Essential for the incision step of excision-repair.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the XPG/RAD2 endonuclease family. XPG subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QAH8"/>
    <dbReference type="STRING" id="1365484.W6QAH8"/>
    <dbReference type="OMA" id="PNSMDFS"/>
    <dbReference type="OrthoDB" id="31113at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004520">
        <property type="term" value="F:DNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09904">
        <property type="entry name" value="H3TH_XPG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09868">
        <property type="entry name" value="PIN_XPG_RAD2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000092">
        <property type="entry name" value="DNA excision repair protein Rad2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000025">
        <property type="entry name" value="DNA repair protein RAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000061">
        <property type="entry name" value="Single-stranded DNA endonuclease (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008918">
        <property type="entry name" value="HhH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006086">
        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001044">
        <property type="entry name" value="XPG/Rad2_eukaryotes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019974">
        <property type="entry name" value="XPG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006085">
        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16171">
        <property type="entry name" value="DNA REPAIR PROTEIN COMPLEMENTING XP-G CELLS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16171:SF7">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02809">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00867">
        <property type="entry name" value="XPG_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00752">
        <property type="entry name" value="XPG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00066">
        <property type="entry name" value="XRODRMPGMNTG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00279">
        <property type="entry name" value="HhH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00484">
        <property type="entry name" value="XPGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00485">
        <property type="entry name" value="XPGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00841">
        <property type="entry name" value="XPG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00842">
        <property type="entry name" value="XPG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XPG N-terminal" evidence="15">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="XPG-I" evidence="14">
        <location>
            <begin position="821"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="471"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="534"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="618"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="654"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1029"/>
            <end position="1126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1062"/>
            <end position="1072"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1079"/>
            <end position="1094"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="1114"/>
            <end position="1126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00053135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CDM33420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="1126" mass="127604" checksum="F82BA594B4BA443A" modified="2014-04-16" version="1">MGVTGLWTVVQPCARPIKLETLNKKRLAVDASIWIYQFLKAVRDKEGNALRNSHIVGFFRRICKLLYFGIRPVFVFDGGAPVMKRQTIAGRKKKREGHREDAARTAGKLLAVQMQRSAEEENARRRNKTHIQEEEEVPDAPVYAEEAFMTETEKQQNRRFKKKDAYHLPNLGVSLQDMGAPNDPRIMSQEELEEYARHFHQGQDINLYDFSKIDFDSLFFLSLPATDRYNILNAARLRSRLRMGYSKEQLDTMFPDRMAFSRFQIERVAERNDLTQRLMNINGMNGDEAFYNSGKRVAGERGREYVLVKDSEHEGGWVLGVVGNREGHEEKPIDLDRPEILSDEDEVSDEDEFEDVPIEGLNRLPKLPFLQEGVLDRSLQLQTNEVLDMRRAIQESRHAAQQQSVNDRRVQEVEDDSLFVEAEGNIAAQQQNNDTDEFFNGDGDDDDLERAIALSLQPDKVDDEDMPDMPINRPVESAPPYETVPDLDSESDDGMDFAAAIARTKVSKKASHAPTRFGGPLPFESIKLTKVTKDNDKAGEVGENAGGFLKGPTEKPKQPDPLPPWFVGERSDVGFIVDPIEDPEKDDERSAVPDHMFLSNRRSPDIIDVDEISATTEVVDLEKREEEEAEEEKENSKQIFQMEDIEKIYNELPTNLHEKPLSEPAPAQVNRNLDETALGRPETQIQDQVPAVEELSSRSEKSPSPEFEDVVPQLPTQGPEITVVSHQKAQPQPQFFEEVEDFVQDQADYSDPEDEELFKQLAAEGEEHVRFANTLNSAAPSQEAFDYEQELKQLRSQQRNERRDADEVTTIMINECQQLLTLFGLPYITAPMEAEAQCAKLVSLGLVDGIVTDDSDIFLFGGTRVYKNMFNQSKFVECYLTSDLEKEYALHRRKLISFAHLLGSDYTEGIPGIGPVTALEILTEFSSLEEFREWWTELQMGTNNAEDAHLAFRKKFRKKASKIFLPPSFPDAKVDEAYLEPAVDDDPSQFQWGVPDLNALRTFLMTTIGWSQERTDEVLVPVIRDMNRREQEGTQSNITHFMQGPQGAGAFAPRVRTGGPSRMEKAFSRLRQEAQTGETSRDGEPANKDGEKEAPISQSKGKRGGSTTKGKAGTNKKRKTRHATSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W6QBG0</accession>
    <name>W6QBG0_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Calcium/calmodulin-dependent protein kinase type I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">cmk1</name>
        <name evidence="7" type="ORF">PROQFM164_S03g000772</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QBG0"/>
    <dbReference type="STRING" id="1365484.W6QBG0"/>
    <dbReference type="OMA" id="RPKVQPC"/>
    <dbReference type="OrthoDB" id="40902at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05117">
        <property type="entry name" value="STKc_CAMK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000257">
        <property type="entry name" value="Calcium/calmodulin-dependent protein kinase type I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000153">
        <property type="entry name" value="Calcium/calmodulin-dependent protein kinase type I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 3 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="18"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="331"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="337"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM34048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="403" mass="44915" checksum="46A5AEB47A0A1F2A" modified="2014-04-16" version="1">MAAQPPSGQKPKVQPCRYKTGKTLGAGSYSVVKECVHIDTGRYYAAKVINKRLMSGREHMVRNEIAVLKKVSLGHQNILTLVDYFETMNNLYLVTDLALGGELFDRICRKGSYYESDAADLVRAVLSAVAYLHDHGIVHRDLKPENLLFRTPEDNADLLIADFGLSRIMDEEQFHVLTTTCGTPGYMAPEIFKKSGHGKPVDIWAIGVITYFLLCGYTPFDRDSNLEEMQAILAADYSFTPVEYWRGVSQEARNFINSCLTVNPQSRMTAHEALQHPWVNQASDSGKVGSGEDLLPTVKKNFNARRTLHRAIDTVRAINKLREGGGFMMDGVLSVDPKPERVNGDDITEEEHHAPPPAPANAGGAQMQIDSRGNARGQTEEQIRAQERRVKEMVAGLWSRTPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>W6QDB7</accession>
    <name>W6QDB7_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">asparagine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PROQFM164_S03g000780</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.22" evidence="2"/>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QDB7"/>
    <dbReference type="STRING" id="1365484.W6QDB7"/>
    <dbReference type="OMA" id="PEMAFYD"/>
    <dbReference type="OrthoDB" id="43906at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004816">
        <property type="term" value="F:asparagine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006421">
        <property type="term" value="P:asparaginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04318">
        <property type="entry name" value="EcAsnRS_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004522">
        <property type="entry name" value="Asn-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00457">
        <property type="entry name" value="asnS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594:SF34">
        <property type="entry name" value="ASPARAGINE--TRNA LIGASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594">
        <property type="entry name" value="ASPARTYL/LYSYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="8">
        <location>
            <begin position="172"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM34056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="535" mass="59783" checksum="D7E26932B99E5F5C" modified="2014-04-16" version="1">MQIWRRTFATSVGRLNQSSINSRPSLVRCAQILQASKNGGVCSFEDQEIKVNGFIRSVRKQKRFAFAEISDGSTVVPLQAILKPAQAADLSTGTAIEISGIWKACPPGKEQTHELQTSDVKIIGAADPETFPIQKKYHSPDFLRQIPHLRIRTPFNSLLSRFRSECIFQLGNVFHSHPDGAFTQVQPPLITSSDCEGAGETFTLAPRGAATPTTENEHFFRAPKYLTVSSQLHLEAYAAELGNVWTLTPVFRAEKSDTPRHLSEFYMLEAEVNFMSDLDSLTGLVEHLLRDLTRRLYNTHVGQEILSAKRSGEPGQETAEETTGSLRQRWTDLMDGPKWHRVTYTQAVEMLQRAVAEDGASFEHSPTWDGGLQLEHEKYIVEVLHQGRPVFVTDYPKSVKPFYMAPSQVADGSNTTGETVACFDLLLPEVSEVAGGSLREHRLPDLIQNMREHGLIKPRQIPESGDTAPDESLYPHLTPDEDLSHLQWYADLRRWGSAPHGGFGLGFDRFLGYLTGVSSVRDIVSFPRYFGRADC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W6QDZ8</accession>
    <name>W6QDZ8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Bifunctional purine biosynthesis protein ADE17</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">ADE17</name>
        <name evidence="14" type="ORF">PROQFM164_S01g001608</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Bifunctional enzyme that catalyzes the last two steps of purine biosynthesis. Acts as a transformylase that incorporates a formyl group to the AMP analog AICAR (5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide) to produce the intermediate formyl-AICAR (FAICAR). Also catalyzes the cyclization of FAICAR to IMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(6R)-10-formyltetrahydrofolate + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide + (6S)-5,6,7,8-tetrahydrofolate</text>
            <dbReference type="Rhea" id="RHEA:22192"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:58467"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="ChEBI" id="CHEBI:195366"/>
            <dbReference type="EC" id="2.1.2.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide</text>
            <dbReference type="Rhea" id="RHEA:18445"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:58467"/>
            <dbReference type="EC" id="3.5.4.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Purine metabolism; IMP biosynthesis via de novo pathway; 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route): step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; IMP biosynthesis via de novo pathway; IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PurH family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QDZ8"/>
    <dbReference type="STRING" id="1365484.W6QDZ8"/>
    <dbReference type="OMA" id="IKHNNPC"/>
    <dbReference type="OrthoDB" id="6017153at2759"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00133"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003937">
        <property type="term" value="F:IMP cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004643">
        <property type="term" value="F:phosphoribosylaminoimidazolecarboxamide formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01421">
        <property type="entry name" value="IMPCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.20:FF:000003">
        <property type="entry name" value="Bifunctional purine biosynthesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1380:FF:000003">
        <property type="entry name" value="Bifunctional purine biosynthesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.440:FF:000001">
        <property type="entry name" value="Bifunctional purine biosynthesis protein PURH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.440">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1380">
        <property type="entry name" value="Methylglyoxal synthase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00139">
        <property type="entry name" value="PurH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024051">
        <property type="entry name" value="AICAR_Tfase_dup_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024050">
        <property type="entry name" value="AICAR_Tfase_insert_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011607">
        <property type="entry name" value="MGS-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036914">
        <property type="entry name" value="MGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002695">
        <property type="entry name" value="PurH-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005492">
        <property type="entry name" value="PRK07106.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00355">
        <property type="entry name" value="purH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11692:SF0">
        <property type="entry name" value="BIFUNCTIONAL PURINE BIOSYNTHESIS PROTEIN ATIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11692">
        <property type="entry name" value="BIFUNCTIONAL PURINE BIOSYNTHESIS PROTEIN PURH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01808">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02142">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000414">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00798">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00851">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52335">
        <property type="entry name" value="Methylglyoxal synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51855">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="7" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MGS-like" evidence="13">
        <location>
            <begin position="1"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00050488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00050687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00054363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDM27797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="595" mass="65172" checksum="E54412FC5DC73D95" modified="2014-04-16" version="1">MSQQKTAIISVYDKTGLLDLAKGLVKQEVRLLASGGTAKMIREAGFPVEDVSAITKAPEMLGGRVKTLHPAVHGGILARDIESDEKDLAEQKISKVDYVVCNLYPFKETVAKVNVTIDEAVEEIDIGGVTLLRAAAKNHKRVTILSDPLDYSDFLKELEAGAITEASRKQYALKAFEQTADYDTAISGFFRKEYAGNGAQQLSLRYGINPHQKPASAYMVQGQLPFKVLNGAPGYVNLLDALNAWPLVKELKQALGFPAAASFKHVSPAGAAIGVPLNEKERKVYMVDDIQDIETSGLAQAYARARGADRMSSFGDLLALSDIVDVPTARIISREVSDGVIAPGYQPEALAILSKKKGGKYLVLQMDEDYTPAPEETRTIYGVHLTQQRNDVVISPSKTFNTIITPKTTTSLPEAALRDLTVATIALKYTQSNSVCYALNGQIIGLGAGQQSRIHCTRLAGDKADNWWMRFHERVIGIKWKQGTKRADKSNAIDLLCSGQTPRTEAETAEYERVFEEVPAPFTQEEREAWLQKLSEVAVSSDAFFPFIDNVFRAARSGVKYIAAPTGSQNDTPVFETAEKLGITFVEQGIRLFHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W6QE09</accession>
    <name>W6QE09_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Mg2+ transporter protein, CorA-like/Zinc transport protein ZntB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PROQFM164_S03g001460</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QE09"/>
    <dbReference type="STRING" id="1365484.W6QE09"/>
    <dbReference type="OMA" id="NMAWVEA"/>
    <dbReference type="OrthoDB" id="341259at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050663">
        <property type="entry name" value="Ankyrin-SOCS_Box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24193:SF121">
        <property type="entry name" value="ADA2A-CONTAINING COMPLEX COMPONENT 3, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24193">
        <property type="entry name" value="ANKYRIN REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="850"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="884"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="70"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="119"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="152"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="185"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="375"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="408"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="423"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="443"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDM34735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="1005" mass="113445" checksum="9671AF885583B4A2" modified="2014-04-16" version="1">MAAAWKNHADILHLLIMRGADVNQRDLRRRNALHNLAADRACRWGWGEEVVGLLLRTECAIDGVAGQDELGRTPLHWACATGNWRMAEMLLTRNAGEGEKEGEVRGSGLGAQIDAVELRGKTALHVATAHDRADIVQLLIAHKAAVNAASDGGWTPLHNACDKGCEAIVRILLSEGAHINAQLLNGITPLHLAAQGGHREVVQCLLEKPDLKRRVRDNFGSTPFLRAAQFKRKDIVLLLAPFNNVDSLSDGVKEACAAFDATVVDFGNFHNENRVKRMSVFNLLYGRDPENPRKQAVTTVPVDSRGTDFRWIHLPANNMAWVEALLTKSFIEEGAHDVDGFKGLEKSFNYQHRGQRTHSHFMRPLCQNTPRTMLRRHEEETPEEPASENGQVRAMDSPARKQKGTGSKPEKADSYFHDEGHGKKNKNNPKRGKSGSVPGTPKQETKGKSGQGEKQRSSLSSSTFCKDPHPLVSACNVCVFMPYLHFETTERRQQMQDAISRAETLDFIPRGIKRTRTRDEILIYAHLSSSTTSLHVRRTLDQFFYPNIDTKSRDQDQVVYRYQTKSPGMGADPKIFMVDQLWMWVLGTNLIVTAFPQRWDQPKNDPLNVLDGIIEDINSKTRDPVKSVYDLAMIITNRCSGVFDRHRLGDEEYQFLDMFESSIGIATDKETVLFNQFNHASGQASEWLKSHRKLNGSFSSPPKSYNGTDEQDQSSNYCDEDGQPLFVDRLLDIGQETNLLAETKDIRDELNMIRTVLEHQNNVLLDFQEVVCETYQGQHRSQFEVKKRFKDQQRMIDMHLKDIDRMDKQAERIYHSITDLLDLKQKHANAFEARFARDQAAGTTRQSKTIMVFTIVTIVFLPLSFIASIFTINLKEFESLNLGYVAKYTFGIGFAISIPLVWVALTVDDIGGFFRVGSRRWLSNRAKVSAKSERSEETLQALEMEKIMSLPRMRRSVDVEYGGGLLPVSTRGTGASRRPDLYGGLSNGTMRKSYDLRPSMDSRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2024-10-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>W6QEB5</accession>
    <name>W6QEB5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S03</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S03g001805</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM35078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QEB5"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM35078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="84" mass="9466" checksum="F45874FCAD9EFEE3" modified="2014-04-16" version="1">MPMNSLWICIHCSWYYEIFGVDPLVNTERCFQKGSSVAAHVTVHQDMRRGPHGYHGHVVVSMDLVVQPFLPSVLADGFERNGHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2024-10-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>W6QEC8</accession>
    <name>W6QEC8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S02g002710</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QEC8"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM32559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="93" mass="9963" checksum="6800B6905E3D6F8F" modified="2014-04-16" version="1">MTFCTSHLVKAQPRAALGAAVLRDTGTPRHGHPPGRYTGYLEEGGNWLEATDGPRQGFATGKPSILFRHRGPSLVSGEQPTYTAGWGVIEGFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W6QEG8</accession>
    <name>W6QEG8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S02g002750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QEG8"/>
    <dbReference type="OMA" id="NGFTPWR"/>
    <dbReference type="OrthoDB" id="5403091at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022085">
        <property type="entry name" value="OpdG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053204">
        <property type="entry name" value="Oxopyrrolidines_Biosynth-assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38797">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP85-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38797:SF7">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12311">
        <property type="entry name" value="DUF3632"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="346"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="359"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM32599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="381" mass="43674" checksum="214BA609D59B429F" modified="2014-04-16" version="1">MHRLRDSLLSPSPKGFPVIGEADTVSHSQQDVRQSLARGEFREVRGAAFFSRTWIVTDRYCNVKDGVDSLEGYVREIWYMYYHLSLHTSHETPEHDSLVLDILRIQGKGPLTRPVKGNYGIDIARLTEGTLWNDLPFLVTDMTDLWINNCGPMSGTQRLNFASFLAKLASTRVCKDRMCQVALVLFRCAFEERQELRTSEDQDNEDPGRSMGSLELMHLLPSVQAWFVEARYNFLQLSEVSWNDCPSTIGQGGPCFIESDFGKRCSPTGFTPWRWMYWLKRLHEIQDAAKDAGEKRLKQCAVEAISRMLMDVKERNSDILRVFKDAGDLIYEDKHLVSLKRIVEGEGPFFPENEDGEESEKTEGKEKLEESKMPEGNKKDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W6QEQ5</accession>
    <name>W6QEQ5_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">U6 snRNA-associated Sm-like protein LSm6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PROQFM164_S03g001677</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Component of LSm protein complexes, which are involved in RNA processing and may function in a chaperone-like manner, facilitating the efficient association of RNA processing factors with their substrates. Component of the cytoplasmic LSM1-LSM7 complex, which is thought to be involved in mRNA degradation by activating the decapping step in the 5'-to-3' mRNA decay pathway. Component of the nuclear LSM2-LSM8 complex, which is involved in splicing of nuclear mRNAs. LSM2-LSM8 associates with multiple snRNP complexes containing the U6 snRNA (U4/U6 di-snRNP, spliceosomal U4/U6.U5 tri-snRNP, and free U6 snRNP). It binds directly to the 3'-terminal U-tract of U6 snRNA and plays a role in the biogenesis and stability of the U6 snRNP and U4/U6 snRNP complexes. LSM2-LSM8 probably also is involved degradation of nuclear pre-mRNA by targeting them for decapping, and in processing of pre-tRNAs, pre-rRNAs and U3 snoRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Component of the heptameric LSM1-LSM7 complex, which consists of LSM1, LSM2, LSM3, LSM4, LSM5, LSM6 and LSM7. Component of the heptameric LSM2-LSM8 complex, which consists of LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8. The LSm subunits form a seven-membered ring structure with a doughnut shape.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QEQ5"/>
    <dbReference type="STRING" id="1365484.W6QEQ5"/>
    <dbReference type="OrthoDB" id="268799at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005732">
        <property type="term" value="C:sno(s)RNA-containing ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01726">
        <property type="entry name" value="LSm6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000037">
        <property type="entry name" value="U6 snRNA-associated Sm-like protein LSm6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016487">
        <property type="entry name" value="Lsm6/sSmF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11021">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN F SNRNP-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11021:SF1">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="11" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="9" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="8" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Sm" evidence="16">
        <location>
            <begin position="63"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00025365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00025892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CDM34950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="132" mass="14590" checksum="A5EEF4A29CE99D09" modified="2014-04-16" version="1">MLSHFLAYSGSRHRPAYRLIKCITHRLTGLLLSNASSLRLLQNTSQPDHSINMENAATSEGKDPSVFLSEIIGAPVIVKLNSGVVYKGELQSVDGYMNIALEKTEEYVNGKLRRNYGDAFVRGNNVLYISSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W6QER8</accession>
    <name>W6QER8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NmrA-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S03g001260</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QER8"/>
    <dbReference type="STRING" id="1365484.W6QER8"/>
    <dbReference type="OMA" id="VISCFAT"/>
    <dbReference type="OrthoDB" id="9974981at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05259">
        <property type="entry name" value="PCBER_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051609">
        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045312">
        <property type="entry name" value="PCBER-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706:SF1">
        <property type="entry name" value="CIPA-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12460)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="5"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM34536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="293" mass="31188" checksum="F70E382A6EE52510" modified="2014-04-16" version="1">MANIKVALAGASGNLGPAVLKELLAAGFDVTVLTRQGSDKTFDSRAHVAQVDYESLDSLKAALSGQEAVVSTLHVGAVPISTHLRLIDVAVAAGVKRFIPSEYGCDTTNPLTSKLPVYGDKVVIQEHLKNVAKESGLSYSFLITGLFLDWGLEKGLIVNFAGPATLYDGGDRRFSATTLAGIGKGVVGIINNLDATKNSTVYINEARVTQNELLELSGKSLETKVVQTADLEQQAFAELAKPAPNRTIFATNLILRAVFGEGYGGLFDPEKVSNELFGLKILSKEELRGLIPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W6QF07</accession>
    <name>W6QF07_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S03</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S03g001782</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM35055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QF07"/>
    <dbReference type="STRING" id="1365484.W6QF07"/>
    <dbReference type="OMA" id="NTRGHCT"/>
    <dbReference type="OrthoDB" id="4440408at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM35055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="325" mass="37270" checksum="4EA515085B9AA3B6" modified="2014-04-16" version="1">MSAKLNILQKDKATEPQAGEMQSSEELPTYQEIAKSPEKSSEKDLLYKTKNAQKPEDLLVHLLSTELNIDDKKTLIRNAPSRIYDSDHHRQNAEKVEAQLKDAGYSQLAIVLYWCFFWHGVQPRGPESWIKELIENDIERRWIAQRRARIQEKVQTLETSSDLLLSSEGEAEHASQLELYKGLLQDLNRSHWALSRKSWNKRESIKSWSFSRAYNIQRSYPDWYLSTSLSDDCAGRGGCCGRSCGCCERPRTVDGFEDHIGTRGHCTTACSCCMKAHGVEDLDDLLVEEIPDLEELCFEYKKPSCMTHQSLRLLMGYAFNLPKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W6QF74</accession>
    <name>W6QF74_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S02g002910</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QF74"/>
    <dbReference type="STRING" id="1365484.W6QF74"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM32759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="76" mass="7653" checksum="98EB26449FB98531" modified="2014-04-16" version="1">MKSNKTISISTSATSFIPMSSTTPTSTPTSETASSDTSALLTGAKVGTGIGISVAGLAVLSALAFVLFQRRLQSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W6QF86</accession>
    <name>W6QF86_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BTB/POZ fold</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S02g002925</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QF86"/>
    <dbReference type="STRING" id="1365484.W6QF86"/>
    <dbReference type="OrthoDB" id="6359816at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="21"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM32774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="101" mass="11054" checksum="006931F5B6E953B9" modified="2014-04-16" version="1">MLKMEEEISVQSQGVLRALSRCQKSGEFKDPTLVCEGERINVYKVVVCSQSGVLHVACTGNSKEASSGVYEFLDDSKIIVGKPVTGSQLFDLFVKPRVTRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W6QFP8</accession>
    <name>W6QFP8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S04</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S04g000529</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QFP8"/>
    <dbReference type="STRING" id="1365484.W6QFP8"/>
    <dbReference type="OrthoDB" id="3918601at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM35648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="99" mass="10550" checksum="4689CF0B71ED6CE1" modified="2014-04-16" version="1">MESVSPYAVSVTNRSGLIVIVETLFMTWMIIVSLVRLYMRLAVNGPVKLDDVVVFTGSIMAIAHVGSIMDAVSHGLGRPEGQSSPSNLIRAGKVALPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W6QGG3</accession>
    <name>W6QGG3_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Borealin-like, N-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PROQFM164_S02g003401</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the borealin family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM33249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QGG3"/>
    <dbReference type="OMA" id="ITMQQKQ"/>
    <dbReference type="OrthoDB" id="2392550at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032133">
        <property type="term" value="C:chromosome passenger complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051233">
        <property type="term" value="C:spindle midzone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000070">
        <property type="term" value="P:mitotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018851">
        <property type="entry name" value="Borealin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018867">
        <property type="entry name" value="Cell_div_borealin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16040">
        <property type="entry name" value="AUSTRALIN, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16040:SF7">
        <property type="entry name" value="AUSTRALIN, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10444">
        <property type="entry name" value="Nbl1_Borealin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="9" id="KW-0137">Centromere</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Borealin N-terminal" evidence="11">
        <location>
            <begin position="29"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="86"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="272"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="295"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF10444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDM33249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="349" mass="37716" checksum="779C851B20FE0239" modified="2014-04-16" version="1">MSAIKRKSDAMDVTPTGSPSKKMRLTQLQKQALMDNLQLEITERARKLRAQYALQANDLRARIERRVNRIPVSLRKANIGELLEKHNAASSKQRVASPSRKHSPMKVSRIIPSISVDQETSTTRDGRARRGSHDGHFSDKENAPAGCESELKNPKRRVKPAGPGGASRVASQELRGNENRILSPKSNNSRTYPHSPFRASPEKGQPSYLARPTSPLKPTSPLRSRGATVSAGKDQRPPSQAQKTAPRAATGPKPARSPLSRPATRQAERKNSTGSNVSSGTTVIKSTRTGTGPRKATTTSAAAAKKPTARGQAVSMAVKNPSATASMRKTTAPAVAETMPRTRALRKRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W6QGP1</accession>
    <name>W6QGP1_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein PNS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PROQFM164_S04g000486</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Probably involved in transport through the plasma membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the CTL (choline transporter-like) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QGP1"/>
    <dbReference type="STRING" id="1365484.W6QGP1"/>
    <dbReference type="OMA" id="LIVLWTW"/>
    <dbReference type="OrthoDB" id="420519at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007603">
        <property type="entry name" value="Choline_transptr-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12385">
        <property type="entry name" value="CHOLINE TRANSPORTER-LIKE (SLC FAMILY 44)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12385:SF88">
        <property type="entry name" value="CHOLINE TRANSPORTER-LIKE PROTEIN CTL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04515">
        <property type="entry name" value="Choline_transpo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="276"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="317"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="348"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="389"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="432"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="474"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="640"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="678"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="115"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="115"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU368066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM35605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="748" mass="82461" checksum="847DBA544CC67425" modified="2014-04-16" version="1">MFSEYASRFLAQSQSRVTSRPDEVQRTGRSRPGQHQGNPRHPSSRSFLRPTDPYRPGASQTAQFPFAPRSSVQQAPLFFSATDEFREEDDETEREREIADFYALQRSRRHFGDSNLKESSELEDSERSGLEESSPYNDRPGKGIKSSWRGEEGVFGARPFPIESVAEAPEHEQAPRSSPSSSKVRGHLVDIGLEDSLRADFDDDQTLSSPGAHDPPVQRFRERELLKEHSGTSQHGFTGEQAEILSQDVPRPPSSASSFPTTVSPLASENTVHDAFWGHLFLISLAGLFASAFLVYLHTSTPSGDKSRWGDTIYMTVHRSFFLLGIYTIVSVLVSLLWLALLRSYVRLLVHVILVAVPTILYSFSLYPFISSFKGPWHGTSIQDKAMRWGSAVPFLIATMWIYNVVRGRQSIGKAIGILEFACRILAANPELLALGLGALICVVSWTWIWMLMFTRVFLGGHLVSSRSFIIDVGSWWLAIYFVVVYLWSVGVIAGIQRAVTAATVSQWYFHRLATPAPTSRQIVQAAIVHAATTLFGTISLSRLLGLLVRLPLLLLPDRICSLLSLFAYSLVPTPITYLTNPLSLTYAAIHSQPLAASSRGLSQMTVLAPSAASTSLNPRSYSRSPRSSGSLLSYRLSKLILYAARFIMSLALGFGGWVTTARSLTMSASGGTIRGSLYAYVVGLIAGTIGWTTLGAMEGVIADIVDAAVICWASEVGIYGREARYCREAGWLFGDSQPHLGHEYQEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>W6QH32</accession>
    <name>W6QH32_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Probable transposable element</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PROQFM164_S03g000233</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QH32"/>
    <dbReference type="STRING" id="1365484.W6QH32"/>
    <dbReference type="OMA" id="IMITTYD"/>
    <dbReference type="OrthoDB" id="413460at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18005">
        <property type="entry name" value="DEXHc_ERCC6L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000019">
        <property type="entry name" value="DNA excision repair protein ERCC-6-like 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058052">
        <property type="entry name" value="DEXHc_ERCC6L2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029256">
        <property type="entry name" value="Heliccase-ass-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057931">
        <property type="entry name" value="RHH_ERCC6L2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050496">
        <property type="entry name" value="SNF2_RAD54_helicase_repair"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629:SF7">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629">
        <property type="entry name" value="SNF2/RAD54 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25806">
        <property type="entry name" value="RHH_ERCC6L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14773">
        <property type="entry name" value="VIGSSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="233"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="606"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="23"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="982"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="30"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="81"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="104"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="982"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1010"/>
            <end position="1022"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM33509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="1022" mass="116828" checksum="4E0447E623B24B7C" modified="2014-04-16" version="1">MANNEDTDEAIIIDSDDDDLEVTHYATPTARDRFSGLKHGADTPVKPESSRTHLSESSSAVKIQPVDSDEDNTNDGELAYKKFKERKSLKRKQDAAATRKAKAPRRDAIVGRIKQERPTPRPKRPLKQWGEASSDDDLMENTLPGYLKSRRSQFDQKLEHLKDHGLKLPPTYEDVDFSDDERLEELQERPVFPDNTRKQEYKDIQLPYSMGIIPAPIAQWLRQYQVEGVAFLHELFVYQKGGVLGDDMGLGKTIQVIAFLTAAYGKTGDERDAKRMRKIRRSDDSAWYPRTLIVCPGSLIANWKAEFACWGWWHVESYHGDNKDLALDAAKSGRVEVLITTYTTYMNNKNAVNMIEWDCVIADECHKIKERKSGTTQSMNEINALCRIGLTGTAIQNKYEELWTLLNWTNPGVLGPVSTWKAQISEPLKIGQSHDATLSELSRARRTAKKLVENLLPQFFIRRMKSLIADQLPKKVDRVVFCPLTETQAEAYENFLDSDIVDYIKTSTEPCDCRSGKKAGWCCRRFIPDRDPPTWQSYVFPAINVLQKLSNHLAILIPQGADPKEKQEKDRDYLELALPEQWEDLYRSRDSIVNYANPEFCGKWKVLRKLLKWWHSNGDKVLIFSHSVRLLKMLQMLFHHTSYNVSYLDGSMSLPDRSKAVDEFNADSRQFVFLISTKAGGVGLNITSANKVVVVDPNWNPSYDLQAQDRAYRIGQLRDVEVFRLISAGTIEEIVYARQIYKQQQANIGYNASSERRYFKGVQEKKDQKGEIFGLKNFFGYQNTNIVLRDIVNRTNVAESRAGVQVVDIDLKAEEEGHDYTDRPMKSEDEAMSQIAAMICGEDEEKDHKPPAGLPMATPHKHDPVQAILASAGVEYTHLNNEVIGSSRVEEDLSRRAELAPNDTTGDRQVFMSSQPYSQPTEQPVRFKYHPPGDVIRRQFCSMARRFGYADATEFALVVEGMTQAQRRACLDQWYRERREKLLSADQNTKEEIKDENVSKEDMDEDEWIKDDKGPKEDSPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W6QH72</accession>
    <name>W6QH72_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PROQFM164_S03g000273</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FM164</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QH72"/>
    <dbReference type="STRING" id="1365484.W6QH72"/>
    <dbReference type="OMA" id="IHDLCLH"/>
    <dbReference type="OrthoDB" id="1844152at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11041">
        <property type="entry name" value="CYP503A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206:SF5">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12 13" id="KW-0349">Heme</keyword>
    <keyword evidence="9 12 13" id="KW-0408">Iron</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 13" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="8 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="16"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="12">
        <location>
            <position position="479"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CDM33549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="535" mass="60191" checksum="2AB40577726995B6" modified="2014-04-16" version="1">MAFLYDLNWIDVEPRILTIVLCLLVSFLFFSVAAAALVFTSYLMANNQVPFSVRKDCFSILYQQYKFVVDGPSIIKKGYEQFANGLFEIPRTFRFGQVILCQPELIEELRNKRSTLVSPEPWIDQLLQVSHVMPGYFPKEMGWPKIAKITPGLIRATVYKHLHRYMPAMNQAIISQLQTLEFKDGECEIGCFDLAYSIVARSGSFAIVGSRLSQNEEYLKAVKDHILGMIVTTRVQFLVPDFLKPYIGGLIDRLATLGTSWDMHASRKIMLKHFDARAAEYHAEISGGKGPSETNLDKSNTPVEIFQWLYESSVLRERWTYAEVIGEMLLLQFAFIYTTSYGLYGALAELARRPEYIAPLREEIDMFFSAMGPTVPACDGMVLMDSFLKECQRLHPPSALSAHRVCVSDLKLSNGITLKQGSHVAVPSGIIQRSSEHYANPDAFDGFRFVKRAAAGAKDSRLVDLSPDYLVFGMGAHACPGRWMASALMKLAFAHILDQYDVLLPNSASLPLTGSLSFEEFYVPNFGVKIALRQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W6QHB8</accession>
    <name>W6QHB8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S05g000046</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QHB8"/>
    <dbReference type="STRING" id="1365484.W6QHB8"/>
    <dbReference type="OMA" id="QILNMPF"/>
    <dbReference type="OrthoDB" id="419770at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="260"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="429"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="521"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="591"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="438"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="608"/>
            <end position="617"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM36213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="655" mass="73491" checksum="924198146D2B0E56" modified="2014-04-16" version="1">MPQRQLSRTLPKNFTFSLGDEPRTPERPHTAMNVPPPPRHSISNGRLPRVRARAGTNVCARMDMDMFHFHGSDVPLPSIEVPQSTTNFEAPSFRGFAHDEGYLAPPRARMDFKTPPAQIRGTPFDSHDTGNPWPSWDHTPGPNNFKRPDSACSSVSNSSIESIETFASRPSVGSFTSVESDLFDSYFPLEMSKEPEIESPSRPQKQSAHVKASKKSWTRDMDTHLWNTYQIYLQDPTMTPFKMTPGSIPPLGVTSRVARRAKKTWGQKSSRITESVSMRSVDPDEISTPKAMDGELERAWPKSDSKTRRRLKMLCRRKFSISPHYQRIMQSRTPEPVAEMFGPAPDTRVKDFADNSAYTTRDLGVSLVTSSEPTPLSRVTQDLPSTTDWFNNPVFAHVEPPVTKTPSQHLRVESAPSIPRLGSPFVYSTWGPGGSNRQLHDPSARRETIHVPGYRARRNTYFDQSLPNPDDVFASVSRQQQNSSDRDVERRLEDYVRDNKFQDMGHGRVRVRNRGATTSAVNPRDMDQLFSPPSSLNSGPIEPEETTPVLKPPMNPLLDLGENIKRLGSPFRVEGGHKRREAPKRVIRAPALSDPFSSGGPSYVGPHDNTSPMQVSPAQVRDKAPVPLPYNASEDGLSDAERIRRQILNMPFTRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>W6QHT0</accession>
    <name>W6QHT0_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Rad21/Rec8-like protein, N-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PROQFM164_S05g000186</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the rad21 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QHT0"/>
    <dbReference type="STRING" id="1365484.W6QHT0"/>
    <dbReference type="OMA" id="HTDLYEP"/>
    <dbReference type="OrthoDB" id="10071381at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030892">
        <property type="term" value="C:mitotic cohesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990414">
        <property type="term" value="P:replication-born double-strand break repair via sister chromatid exchange"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21788">
        <property type="entry name" value="Rad21_Rec8_M_SpRad21p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.580:FF:000004">
        <property type="entry name" value="Double-strand-break repair protein rad21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.580">
        <property type="entry name" value="Structural maintenance of chromosome 1. Chain E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039781">
        <property type="entry name" value="Rad21/Rec8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006909">
        <property type="entry name" value="Rad21/Rec8_C_eu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006910">
        <property type="entry name" value="Rad21_Rec8_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023093">
        <property type="entry name" value="ScpA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12585:SF69">
        <property type="entry name" value="FI11703P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12585">
        <property type="entry name" value="SCC1 / RAD21 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04824">
        <property type="entry name" value="Rad21_Rec8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04825">
        <property type="entry name" value="Rad21_Rec8_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rad21/Rec8-like protein N-terminal" evidence="6">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="Rad21/Rec8-like protein C-terminal eukaryotic" evidence="5">
        <location>
            <begin position="511"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="242"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="267"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM36353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="586" mass="64134" checksum="3C0A6D039C3BC661" modified="2014-04-16" version="1">MFYSETLLSKTGPLARVWLSANIERKLSKSHILQSDIESSVNAIVDQGQAPMALRLSGQLLLGVVRIYSRKARYLLDDCNEALMKIKMAFRLTNNNDLTSTVVAPGGITLPDVLTESDLFTNLDTSLLFPQTLDLEPAGKRPGGMDFGSQFLPDSSFRRSVSQEPARLEDPSLVDLNFSDDEVPLGNDPTMEIGRDAPAPRPVGDDLFNDAGKFNDDDDLGLDLGDDEALDKMDLGDDVHDNLNDLLPDGPMDFNNDNDFDGGETPRAAENRFERDSESPLSDAGSDQINQLEEEINRDVSATPDAVSAHQGQRTKRQKLMGLDKQVAISSSKIKDQQNDRSSILKPASFLPRDPVLLTLMTRQQNGNFVSSVFGEDRGRGWAPELRGMLSLDSVKKAGELKRKRDSGISDMDVAAVDVPALDLGDEEAMVPIDEGIALDTTMNQRSEIEFPGDDEDVLHLNEDDDNNQPMDELDDTIAHPVDTEPVSMGTKHAVHILREKLGSPATQQEKSVLFQELLPEQRSSKADATKMFFEILVLATKDAVKVDQGAKSIGGPLKVTGKQALWGSWAEENASGAMSQLSQAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W6QID5</accession>
    <name>W6QID5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S04</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S04g000632</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QID5"/>
    <dbReference type="STRING" id="1365484.W6QID5"/>
    <dbReference type="OMA" id="AIHTDCF"/>
    <dbReference type="OrthoDB" id="2148716at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13577">
        <property type="entry name" value="SnoaL_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="13"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM35751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="160" mass="17191" checksum="7D6A2653770179B3" modified="2014-04-16" version="1">MTSFSLPAALTPTLSGRDAIADALYRCVLGLDTNDLALFDSAFTSTATFSIGDKTFSGLPAIHTDCFEVISKLDTTHFVTNIRINIADSGVKAAATASALAQHYRGGKGNEPDQPRLMSGAQYYADLVKDNESGLWKIEAFKMTLSWTEGDWGVMNSIEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W6QIJ0</accession>
    <name>W6QIJ0_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Major facilitator superfamily domain, general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PROQFM164_S05g000466</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QIJ0"/>
    <dbReference type="STRING" id="1365484.W6QIJ0"/>
    <dbReference type="OMA" id="YSFPLER"/>
    <dbReference type="OrthoDB" id="440553at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF150">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="25"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDM36633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="170" mass="18551" checksum="1E75B3176993ECEA" modified="2014-04-16" version="1">MAIGVVAFIPYGWVLQQRVHLAAPLVLQFIIGFCFVAALNCLNTLLVDLFPDKPATAASACNLVRCCLGAVGAAVISQMLSGMGWGWCFFFLGLAMTAGMGLLWVENVYGMGWREKRLLKIEQKMEKDARAAEIQIEGKADGREQKDTNVQELVAGANDANVAEEPRRTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W6QIM1</accession>
    <name>W6QIM1_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Adrenodoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PROQFM164_S04g000722</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the adrenodoxin/putidaredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QIM1"/>
    <dbReference type="STRING" id="1365484.W6QIM1"/>
    <dbReference type="OMA" id="QSPWQGY"/>
    <dbReference type="OrthoDB" id="268593at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140647">
        <property type="term" value="P:P450-containing electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001055">
        <property type="entry name" value="Adrenodoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018298">
        <property type="entry name" value="Adrenodoxin_Fe-S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23426:SF65">
        <property type="entry name" value="FERREDOXIN-2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23426">
        <property type="entry name" value="FERREDOXIN/ADRENODOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00355">
        <property type="entry name" value="ADRENODOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="2Fe-2S ferredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00814">
        <property type="entry name" value="ADX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="8">
        <location>
            <begin position="88"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM35841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="202" mass="22348" checksum="6473193E008BE3F2" modified="2014-04-16" version="1">MAFWREVGQQLRRVPKTGDICLTQSRRSLSYSRSWRNTGITTPSRSQTNAQRSLQSPWKGYNTARRAFSVTAQAAHGHITPPKPGEEINLTFIDKDGTKVDLQVAEGDNLLDIAQANDLEMEGACGGSCACSTCHVIVDDPETFDKMEEPSNDENDMLDLAFGLTETSRLGCQVIMTKDLDGMVVRLPSMTRNLQASDFESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>W6QK21</accession>
    <name>W6QK21_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">acetylornithine transaminase</fullName>
            <ecNumber evidence="5">2.6.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">arg-8</name>
        <name evidence="12" type="ORF">PROQFM164_S06g000129</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM164</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 4/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.11" evidence="5"/>
    <dbReference type="EMBL" id="HG792020">
        <property type="protein sequence ID" value="CDM37168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QK21"/>
    <dbReference type="STRING" id="1365484.W6QK21"/>
    <dbReference type="OMA" id="MVPGFKY"/>
    <dbReference type="OrthoDB" id="5419315at2759"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00109"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003992">
        <property type="term" value="F:N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000004">
        <property type="entry name" value="Acetylornithine aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01107">
        <property type="entry name" value="ArgD_aminotrans_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004636">
        <property type="entry name" value="AcOrn/SuccOrn_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050103">
        <property type="entry name" value="Class-III_PLP-dep_AT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00707">
        <property type="entry name" value="argD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002325">
        <property type="entry name" value="PRK01278.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11986:SF79">
        <property type="entry name" value="ACETYLORNITHINE AMINOTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11986">
        <property type="entry name" value="AMINOTRANSFERASE CLASS III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 12" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="9 10" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDM37168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="479" mass="51586" checksum="4A7D68969BF26D05" modified="2014-04-16" version="1">MSALRVAARRLPRASKFVPAFESPVQRRFATTATAPQNVKSQVKKESTLPNPDPSPDSVTASFINERAPFMVPTYVRPAPMMMKGQGCYLWDMENRRYLDLTAGIAVNSLGHCDPEIAKIIAEQAETLIHASNLYHNPWTGALSQLLIELTQKSGAMRDASQVFISNSGTEANEAAIKFARKTGRTLDPSGEKHEFVSFNNSFHGRTMGALSATPNPKYQTPFAPMLPGFKYGDYNQIDQLQTLITDKTCGVIVEPIQGEGGVNIATPEFLAALRKRCDETGAVLIFDEIQCGLSRTGTFWAHAHPTLAPSSGEAAHPDILTTAKALGNGIPIGATIVSGKTVGQHIKTGDHGTTFGGNPLACRVAHHIVERLADPELQKSVQAKSDLFVSGFQAIQKKFPGVISEVRGRGLILGVQLTPEYIAKAGDIINAARERGMLIITAGNGCIRFVPALTITEDQIQAGLNIFEQAVDSVVAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W6QK59</accession>
    <name>W6QK59_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S05g000603</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QK59"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM36770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="70" mass="7793" checksum="E7865BB62DE7AE53" modified="2014-04-16" version="1">MEDGKFVSCVRIPGMGVSTIAILATRTTVAIGTRVPKRKETPVKQEEDEQLVNDSNLKPANRQSRQLQRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W6QKA7</accession>
    <name>W6QKA7_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="9">C4-dicarboxylate transporter/malic acid transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PROQFM164_S03g001384</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tellurite-resistance/dicarboxylate transporter (TDT) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QKA7"/>
    <dbReference type="OrthoDB" id="1099at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000319">
        <property type="term" value="F:sulfite transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.150">
        <property type="entry name" value="Voltage-dependent anion channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004695">
        <property type="entry name" value="SLAC1/Mae1/Ssu1/TehA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051629">
        <property type="entry name" value="Sulfite_efflux_TDT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038665">
        <property type="entry name" value="Voltage-dep_anion_channel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31686">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31686:SF1">
        <property type="entry name" value="SULFITE EFFLUX PUMP SSU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03595">
        <property type="entry name" value="SLAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="52"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM34659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="116" mass="13587" checksum="D5DD4B78C8AAD987" modified="2014-04-16" version="1">MIRNGPLQSKHESGWRRVVRTFYAHQSRWFSINMGTGVVSILLNTPPYNGKWLYYLCIIVSALNVAYLVMFLAISLLRYTLYPEMARIEPRPMSVQRIWTLPWELCAIMDQSLVHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W6QKI8</accession>
    <name>W6QKI8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S05g000344</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QKI8"/>
    <dbReference type="OMA" id="EYRSIQK"/>
    <dbReference type="OrthoDB" id="4331574at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM36511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="181" mass="21364" checksum="F1AEB22B467718F7" modified="2014-04-16" version="1">MPRTRMSKTNKVAWTSWEKRNLLSWLHRHRRMSWKERSRAYLRQFGVKRTGEVLRCKQNYLLREYRSIQKSLSETTSSGAVSLRVQREEARMSCLPSLPIYAPRGSRTKTRLLIHALEQLAVSERRHLTNDSDNANERLPGYTIRPPHTLRSAPSRHISYHWKFVHRMAAAMRASRNAEIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>W6QKR3</accession>
    <name>W6QKR3_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PROQFM164_S05g000429</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the UPL family. TOM1/PTR1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="4"/>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1365484.W6QKR3"/>
    <dbReference type="OMA" id="ADEMKYG"/>
    <dbReference type="OrthoDB" id="8068875at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2410.10:FF:000004">
        <property type="entry name" value="E3 ubiquitin-protein ligase HUWE1, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2160.10:FF:000001">
        <property type="entry name" value="E3 ubiquitin-protein ligase NEDD4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1750.10:FF:000003">
        <property type="entry name" value="E3 ubiquitin-protein ligase UPL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010309">
        <property type="entry name" value="E3_Ub_ligase_DUF908"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010314">
        <property type="entry name" value="E3_Ub_ligase_DUF913"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050409">
        <property type="entry name" value="E3_ubiq-protein_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025527">
        <property type="entry name" value="HUWE1/Rev1_UBM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254:SF67">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE HUWE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254">
        <property type="entry name" value="HECT DOMAIN UBIQUITIN-PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06012">
        <property type="entry name" value="DUF908"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06025">
        <property type="entry name" value="DUF913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14377">
        <property type="entry name" value="UBM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <keyword evidence="7 11" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="13">
        <location>
            <begin position="3682"/>
            <end position="4018"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="270"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="710"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1155"/>
            <end position="1211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1530"/>
            <end position="1567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1608"/>
            <end position="1653"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1981"/>
            <end position="2033"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="2058"/>
            <end position="2108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="2347"/>
            <end position="2403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="2416"/>
            <end position="2507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="2823"/>
            <end position="2918"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="2993"/>
            <end position="3024"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="3300"/>
            <end position="3386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="300"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="716"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1187"/>
            <end position="1201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1619"/>
            <end position="1632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1635"/>
            <end position="1645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="2006"/>
            <end position="2017"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="2063"/>
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        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="2088"/>
            <end position="2100"/>
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    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="2389"/>
            <end position="2403"/>
        </location>
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    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="2416"/>
            <end position="2433"/>
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    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="2448"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="2464"/>
            <end position="2485"/>
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    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="2486"/>
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        <location>
            <begin position="2823"/>
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    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="2888"/>
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        <location>
            <begin position="2993"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="3300"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="3318"/>
            <end position="3330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="3349"/>
            <end position="3360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="3363"/>
            <end position="3377"/>
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    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="11">
        <location>
            <position position="3985"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDM36596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="4018" mass="447064" checksum="3FCA6A21DC1D3688" modified="2014-04-16" version="1">MGRIKKVASQKHEATISPFLQEFIAHATSIPVPELPSLLNTFPKLWPFPRGDLYHWINVLDRFDEILASAVDKYLLNTGPQTQLFARSVLEESYSADESKKPAEGVDAKLNALGYGPEGDRELVEAVLDFSRLLLEKCGNRSLYSSSDRLGDLLNTTSLSLLQSTLRLSLCLAQRYHSRQRGTHQQSVLQSHYALDLEKLQKIAAPFPRPAIASKTPFGTSSPVLTKGKEITAKTKVNANELVSLVRDDDGWEEWGDVRVLYYPSGSEQARTTSEFGQTEHGSHVPATPTPLRRSAHPTPHSNQASNGDESPAVIGGKAEEATRAGKVLELPYSKVSTAKVEDLLAANLPHLPLESKYELLHKLRVAKALTTSRATREQILSIKALAVTNLAHVQPESTFQAKVLQSDMEQPKRLQLTYQLAEVVHLGASGDLAVSRSVQTLAIQALDALAKHKVRAIDVCAALSVNVNHGILMFLTRKMVNELGPENNDPDDAYYDEWRDALLALLRTLPSSSTRTPETLVAAGLIPMFVDILNLRTEKSRRVYSRIMEFLDTFVHAVRDALGTLTTAKGFDAMSDLIDHETKTAFEKVNRGDGFPAKYKNPSVDYQIPYFQQQTLRWMFRFVNHIMQHNGGGFDRVLRNLIDSPQLLTSLRLVFENARVFGSHVWSNAVNILSSFIHNEPTSYAVIAEAGLSKSLLAAVMGRELHVLEKPPAVEPEDRETETDTEAEPSATQPPSAEAAIQSEGKQKDREYAIVRPQNTPLAPGIMPAADALACIPGAFGAICLNSSGLDLFQSSDALESFFEIFENPEHIKCLKDDPELVRSLGTTFDELVRHHPALKTSIMSAVLVMAARINVLGRVKAWELGMGTKMWTQDADGKTTLSGDVFSLFREIGTAVDAPIDDPASFGAPQLNSNTLPNGAKLVVGDLDHVLPSPGPNFEPRDKDDHGLSATDYLFPALRFLGAFFENQTNCTSFILAGGTEFLLDIATLQSLAFDFHSTNANQEVTVLIHMLAETKPHLVVPSLVRRAQAAVDNLSAFWTAPTGSGFFTELIKPADSKNPALEPTAAAKSGTFFVRHLNAVLLLTDVLREVFASPLYQTRPGQSTSIFGQANLADHYCSLVSSLSNLLASCVWEGILLEKNIPEKWLKATQASAEKHGSGKSKAAPVTGNLQEPSATPGAEPQREGTSASETSPAQSGQGPKEDDTEVDEQCPAFKNARTLRYLLSALPTSITGFLHNLGLGIIGKRRTDPLQKQKANAFLVSDAIAEGVLRQLQFDPANSSNSPKHRFAYLIVILSHFSHLLYEVSSDRPSPNYLTSVLVSFNKNNGLKVLKDICDVFLSDIKSLPSAESIPDQDKELADRLASGYGGIKIILGLFADLTAGKFIVDSSQTQALTSHPDRDRDRPDYFQPGQLLVDLRMEILPMARDMWNSDFATQSSSPIVRLLIDIMRFSLDGEYEAGAARKADTPPVLVEVPKKPFVVHTERATALLEKGYTDVDLNKEALYRCNNLLTAAEEYCKAQQWLRAPPRVPPSPGDIKTGLPESASGIDLLDDPGLGEVPPFNTANSLDRSGALQLILAQAQRPPFPGGDIDSDMHRNLAEALDNVLNDNDDMDSDDRGESSNQRRPESRNIGASSSESTAPPQGEPVKRRHMVTIEDLDAERQNIRSNLIDRALDILNEHHDVSFELSDLITSAIKKHNEPVNFRRDIGETLVQSLVSLQMENFQTAGKKIAAYAHILALTLQDPDMYLATLEELKDCFSTFLGFIKLPTPEKADQETFPWVGHVLLILEKLLSDDCQPPQIAWKLPSLDDPNPSGDEPARLEDPLVSLDEKTQLFEALVEILPRVGKDDTLALSMCRVLVILTRERSIAARFGEKRNLQRLFVMVKQLSSATNDKLQSAFMLILRHIVEDEATIRQIMRSEIVANFESKTTRQMDTNGYVRHMYHLVLRAPDIFVEVTNEKLRLLRYDNHQRPQVLGLKADKDRQQKRGRPSVFIEEPKPESSSAGEASAPEGTDKGKAQTKGAELKAPIVENPDGVIHYLLSELLSYKDVDDKETSLESSEQAADQSDTQTDVEMAVDEPTPSISSTAEAQTSRGSKKAEKPQFKADDHPIYIYRCLLLQCLTELLSSYNRTKVEFINFSRKADPLATTPSKPRSGVLNYLLNVLVPLGTMDHDESLVFKKRSITSTWTMQVLVALCTKTGEFGGVGKRRTDPKYEEDEPELAFVRRFVLEHALRSYKDAMASTEPLDVKYSKLMSLADLFDKMLSGYSFTNDAGFPTSTRQLAKTMFEKNFIPALTSSVADVDLNFPSSRRVIKYILRPLNKLTQTAVLLSETSDITIQGDNEDDEISSATSVSDMEDEREETPDLFRHSTLGMLEPRHDEEESSTEESEGEDDEMYDDEYDEEMDYDEDVAEDDGEVVSDEDDDGMGPIEGLSGDAVEVILDEDDDEDEDEDDEDHDHSDMHDDMYDGEIGGDRDNESLEDGAEDEWESEEMTEDEEEVEMMNQFEDEMADIRQSSRHQGEDQHLGDLFRALNGSGVDDIHGDALGGDIHEEIDDLDEDVEDEDEMDELDEDMDDFDEDQGSYEDMEEDDDLLEPWGWEGDEPPMARGHAQSRFRAAPPPAWATVTEIMPGRPSGLVPIQPYHRVHRTQIPTHGNDDGTNPLLVRTDRPDPTVPPRVAADAFADWGQSMDPAGGRVVAMDSPISFMNAIMQAIGGQAAPGFGVVTRPDGIHVHVDRRAVLPGRIQDMLGIPRGAGPPTRTRGDDPHTAVKFGLGTTRNRWQEEAHIIFNSQYIERTQRVVNSILRLLVPPAIEEEKQRQKLAEEERKRVQAERAEKDRQDRIAAEEKQRELKQKEEEENARLQAEKEQQEAERQAAGVDEPMEDVQETDTVEDAGPSNQPEAQPAEPARRVYTNIRGRQVDITGLEIDSEYLEALPEELREEVIMQQLAEHRSQAAAAGEEDTEINQEFLEALPAEIREELLQQEAADRRRRERETARRQAAAAGGAGATSSTQPAEEMDAVSFLATLDPSLRQAVLADQPEDVLATLGPDYLNEARGMGGSGRRMAQFGDMSAIDHRQPAAGQESKKEQRRQTVQMLDKAGVATLLRLMFMPLQGNARHQLNDILHNVCENRQNRSEVLSVLLSILQDGSVDSTAIERSFSHLSLRAKAPGAQKTPQSKRSLAIQTASSVSSEVTPIMVIQQCIAALSFLSQFNPHIAWFFLTEHDSASAGKLKALRKGKGKDNRANKFALNALLSLLDRKLIMESPNCMEQVSSLLSSITQPLTVLLRREKERQEEDKGKKPERPQIEASAEPAEAADSSMDTSMTDAPLPTVETSEVPSEETAEGEEATSAEAKKPEDSKEPTGDGKRKKRTIEPPVVPDHNFRLVVHILAARECNGKIFRDTLSTINNLSAIPGARDVIGNELVAQAQALSDTILGDLEDLLPHIHQAKTGTDMQGLALAKFSPASSDQAKLLRILTALDYLFDQARADKSKDIEPRSAPKEDVLKKLYESATFGPLWSKLSDCLTVIRQKENMLNVATILLPLIEALMVVCKNTTLKDQPLSRGSRELSVNSTPADAGLSMENIFFKFTEEHRKILNELVRQNPRLMSGTFSLLVKNPKVLEFDNKRNYFTRRVHSRGAEPRHPHPPLQLSVRRAEVFLDSFKSLYFKSADELKYGKLNVRFHGEEGVDAGGVTREWFQVLARGMFNPNYALFIPVAADRTTFHPNRLSGVNSEHLMFFKFIGRIIGKALYEGRVLDCHFSRAVYKNILGRSVSIKDMETLDLDYYKSLLWMLENDITDIITETFSIETDDFGEKQVIDLKPGGHDIPVTQENKEEYVQRVVEYRLVESVREQLDNFLKGFHEIIPPELISIFNEQELELLISGLPEIDVDEWKNNTEYHNYSASSSQIQWFWRAVRSFDKEERAKLLQFVTGTSKVPLNGFKELEGMNGVSKFNIHRDYGHKDRLPSSHTCFNQLDLPEYESYEDLRQRLYTAVTAGSEYFGFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W6QKS3</accession>
    <name>W6QKS3_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S05g000439</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QKS3"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM36606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="52" mass="5728" checksum="20F30ACB924C791D" modified="2014-04-16" version="1">MQIVTQGDAPWSVYYLETATLTPEVLDTQKQLCIAPPISVSPMDYAQVELTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W6QLH9</accession>
    <name>W6QLH9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Natural resistance-associated macrophage protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PROQFM164_S02g000566</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QLH9"/>
    <dbReference type="STRING" id="1365484.W6QLH9"/>
    <dbReference type="OMA" id="YEYYPRT"/>
    <dbReference type="OrthoDB" id="409173at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015086">
        <property type="term" value="F:cadmium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005384">
        <property type="term" value="F:manganese ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030026">
        <property type="term" value="P:intracellular manganese ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034755">
        <property type="term" value="P:iron ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001046">
        <property type="entry name" value="NRAMP_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01197">
        <property type="entry name" value="nramp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF037982">
        <property type="entry name" value="Nramp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11706:SF101">
        <property type="entry name" value="MANGANESE TRANSPORTER SMF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11706">
        <property type="entry name" value="SOLUTE CARRIER PROTEIN FAMILY 11 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01566">
        <property type="entry name" value="Nramp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00447">
        <property type="entry name" value="NATRESASSCMP"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="207"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="241"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="271"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="316"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="392"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="436"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="483"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="513"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="578"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="87"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="16"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="47"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="97"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM30417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="604" mass="64781" checksum="49A718B57E53E0BE" modified="2014-04-16" version="1">MNKTSHTEEPLEGDGYNQSPNPNSSDLTTNEDFNGLVNIRAVRESDTNAVSNAASNVPGQIASDAPTESDGHGKATYRLAQRSIDRGQSTEGGLQTPAAAHPSGSPPASAGGDADPGTLIQRARKMLATFGSFIGPGFMISVAYIDPGNYSTDIAAGASYRFRLLFIVLLSNLFAIFLQSLAIKLGTVSGLNLAEACRAFLPRWLNYILYAFAEAAIIATDIAEVIGFAIALNLLIPKVPLVAGCAISILDVMVTLFFYHPEGSMKGLRYFEMFIICLVLAVVVCFCIQMSMIHGATPGEVFKGYIPSKYLIESEAIYQACGILGATVMPHSLYLGSGIVQPRLREYDERSRLLPRQLASGYTVLDDGIDNGYYVPSLGAIKHSLTVSILELAISLFTFALFVNSAILIVAGAALYQNPLALEADIFGIHDLLSKSISPAAGIIFALALLLSGVSAGIVCTIAGQMVSEGALNWKMKPWLRRLITRTISITPSIVIAGAVGREGLNAALNGSQVALSIILPFVTAPLIYFTCRDKYMTAYPGKARWRMAGRDDESDADQVIGEGAELEPEGVKMTNSWYTMILAVLIWLFMSIMNVANLVFLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W6QLR4</accession>
    <name>W6QLR4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Src homology-3 domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PROQFM164_S04g000040</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SH3YL1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QLR4"/>
    <dbReference type="STRING" id="1365484.W6QLR4"/>
    <dbReference type="OMA" id="SNCKARN"/>
    <dbReference type="OrthoDB" id="443981at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051017">
        <property type="term" value="P:actin filament bundle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11842">
        <property type="entry name" value="SH3_Ysc84p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11525">
        <property type="entry name" value="SYLF_SH3YL1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000100">
        <property type="entry name" value="SH3 domain-containing YSC84-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051702">
        <property type="entry name" value="SH3_domain_YSC84-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033643">
        <property type="entry name" value="SYLF_SH3YL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007461">
        <property type="entry name" value="Ysc84_actin-binding"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15629:SF2">
        <property type="entry name" value="SH3 DOMAIN-CONTAINING YSC84-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15629">
        <property type="entry name" value="SH3YL1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04366">
        <property type="entry name" value="Ysc84"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="350"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="250"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="304"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="255"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDM35159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="408" mass="43564" checksum="92B2358F50A2C49E" modified="2014-04-16" version="1">MGFGIHNPLPASMTSECKKAAKILTSFVDPRQAFGPDKVIPPEILANAKGLAILTVLKAGFLGSGRFGSGIVVARLGDGSWSAPSAIATAGAGIGGQIGFELTDFVFILNDAAAVRTFSQVGTLTLGGNVSLAAGPIGRNAEAAGAASTKGVAAVFSYSKTKGLFAGVSLEGSMLVERKDANEKLYRSRVSASQLLTGSIRPPPAADALMRVLNSRAFQGNARAYGDSMYNDIPVYDDSHDDVVWEGRRGDAYGQGTQRGRSNTSENDYSYSDRPRRANTWADDVYDRPASGLSRSVTARAAADNSFDGYGRNRSNTAPSEEEYTYSDRRPSRPTAPKPIFQQRTGAAQLRSDQAVALFTFDADQEGDLGFKKGEIITIIKRTEKAEDWWTGRIGDRVGIFPSNYVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W6QM47</accession>
    <name>W6QM47_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycoside hydrolase, family 67, alpha glucuronidase, N-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PROQFM164_S04g000130</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QM47"/>
    <dbReference type="STRING" id="1365484.W6QM47"/>
    <dbReference type="OMA" id="KVRDWPL"/>
    <dbReference type="OrthoDB" id="9975416at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015929">
        <property type="term" value="F:hexosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901135">
        <property type="term" value="P:carbohydrate derivative metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="entry name" value="Chitobiase/beta-hexosaminidase domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.460">
        <property type="entry name" value="Hyaluronidase post-catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051822">
        <property type="entry name" value="Glycosyl_Hydrolase_84"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015882">
        <property type="entry name" value="HEX_bac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011496">
        <property type="entry name" value="O-GlcNAcase_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13170">
        <property type="entry name" value="O-GLCNACASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13170:SF16">
        <property type="entry name" value="PROTEIN O-GLCNACASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02838">
        <property type="entry name" value="Glyco_hydro_20b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07555">
        <property type="entry name" value="NAGidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55545">
        <property type="entry name" value="beta-N-acetylhexosaminidase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52009">
        <property type="entry name" value="GH84"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004881762" evidence="3">
        <location>
            <begin position="25"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="domain" description="GH84" evidence="4">
        <location>
            <begin position="184"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS52009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDM35249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="652" mass="71950" checksum="F2316870822F3E4A" modified="2014-04-16" version="1">MFSSHRITCLRAFLLAFALGPVNAASIDHSDLVIHDDGGPAVWPTPQEITFTGGKVSLTGNVTIVTDNFKDSATISTVKGVVAAAGGDAVLASKPSSKGTQIFIGTEAEAGVAVAAAKALAGNSANGLDADGYVLASGKYEQQPSIVINGVDTRGTFYAAQTLRQLLADDHIPGVKVRDWPLMSIRGSIEGFYGVPWSHEARLDQFEFHGKHKMNTYVYTPKYDPLLRAKWRTLYSGDELTQLKELVQTANINHVDFTYALSPGLDVCYSSDEDFNATVTKFNQLRDFGISSFYIPLDDIALEFHCDADKKKWPETENDEWVADAQAFYLNRVQTQYIEPNDLEDLETVPTDYAGSAPTPYKKEFGTKLNKKIRVQWTGEGIFSDNITVESIVRAHSSYVTDNLFLWDNFPVNDNNRDRLFLNPLTKRAAELYKRLVGFTSNPMNQPYASMIALANYGDYTWNAPSYNATKSMNASLWELSGSDTTVHNSLITFTDLNQNWPYQSPEVNAPKLTKDITAFWAGRRTGSSDGTEALKDRLSLIISIPDVLPKMATKAFATDVAPWTTVAKQWATACKHLIAMLEAIDDKDHCTADAEFKSAKKWVEKTKAKTVDDRNADGEDLPKSIVPTTGDGAFDKFLTDATAIYNASRCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W6QMH8</accession>
    <name>W6QMH8_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transcription factor, fungi</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PROQFM164_S06g000132</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792020">
        <property type="protein sequence ID" value="CDM37171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QMH8"/>
    <dbReference type="STRING" id="1365484.W6QMH8"/>
    <dbReference type="OMA" id="NIRWRVA"/>
    <dbReference type="OrthoDB" id="4934715at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF74">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDM37171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="468" mass="52778" checksum="9AF02A88478CC30F" modified="2014-04-16" version="1">MGNQLFLGPSFLREYEEFWTNASNVPIMWIGLPFSMIYLAYITTDTFDAEVEHLSLQIDPSRQKIVQCLVLGEYTRAGPYVLQTVINYVYVEFCLRTDVDQDTWYLLALEVNLAMRMGYHRDPSHFPVLMGDILVSNQMGMPHMISDWKCDTMEPRNLNDTDFDEQSTDLPPSRPLTKYTNSIGLIARRRILAALGIVADLTDAVKPCSYAEVMRVDGVLQDAAASIPPLLQMKSMATSVTDSLQVIISRLFLGHMIYKGQIVLHRRFLYTSPDDADYDSMSYSRKACLAASLGGQLYTMRFRVASIMNHQFLTATMVLCSILHRGKTIQREQDIRAALHLSRFIWMRKSSTSKETKKAAETVSFVLATAGDGRKPDLAFNQDISHGVQDNDQTNAFQGSCAKGTGQNSDEELLFPDNMSLFEPDHFVMTSSLGMFTSPAQQNQHFGVNSNGIESPFEEWMVMNLPQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>W6QMJ8</accession>
    <name>W6QMJ8_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Polynucleotide 5'-hydroxyl-kinase GRC3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Polynucleotide 5'-hydroxyl-kinase grc3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">clp1</name>
        <name evidence="9" type="synonym">CLP1</name>
        <name evidence="14" type="ORF">PROQFM164_S02g000942</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Polynucleotide 5'-kinase involved in rRNA processing.</text>
    </comment>
    <comment type="function">
        <text evidence="9">Required for endonucleolytic cleavage during polyadenylation-dependent pre-mRNA 3'-end formation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of a pre-mRNA cleavage factor complex. Interacts directly with PCF11.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the Clp1 family. Clp1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QMJ8"/>
    <dbReference type="STRING" id="1365484.W6QMJ8"/>
    <dbReference type="OMA" id="VQYVNCH"/>
    <dbReference type="OrthoDB" id="258143at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005849">
        <property type="term" value="C:mRNA cleavage factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051731">
        <property type="term" value="F:polynucleotide 5'-hydroxyl-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006388">
        <property type="term" value="P:tRNA splicing, via endonucleolytic cleavage and ligation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002095">
        <property type="entry name" value="mRNA cleavage and polyadenylation factor clp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.1030:FF:000001">
        <property type="entry name" value="Protein CLP1 homolog 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1030">
        <property type="entry name" value="Clp1, DNA binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.330">
        <property type="entry name" value="Pre-mRNA cleavage complex subunit Clp1, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03035">
        <property type="entry name" value="Clp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028606">
        <property type="entry name" value="Clp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045116">
        <property type="entry name" value="Clp1/Grc3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010655">
        <property type="entry name" value="Clp1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038238">
        <property type="entry name" value="Clp1_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032324">
        <property type="entry name" value="Clp1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038239">
        <property type="entry name" value="Clp1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032319">
        <property type="entry name" value="CLP1_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12755">
        <property type="entry name" value="CLEAVAGE/POLYADENYLATION FACTOR IA SUBUNIT CLP1P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12755:SF6">
        <property type="entry name" value="POLYRIBONUCLEOTIDE 5'-HYDROXYL-KINASE CLP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06807">
        <property type="entry name" value="Clp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16573">
        <property type="entry name" value="CLP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16575">
        <property type="entry name" value="CLP1_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Clp1 N-terminal" evidence="12">
        <location>
            <begin position="27"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="Clp1 P-loop" evidence="13">
        <location>
            <begin position="150"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="Clp1 C-terminal" evidence="11">
        <location>
            <begin position="378"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="401"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="153"/>
            <end position="158"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF06807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF16573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF16575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDM30792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="553" mass="58617" checksum="9A1794E7F0054FF5" modified="2014-04-16" version="1">MSLPGLELTQPSEERSQAPAPPSQINLTPGSEWRFEVAFGHIIKVKLLNGTAELFGTELAESQTYTFTGTKAAIFTWHGCALEVTAVETTSTTSDGVTPTVGHGAGGCQSEYTAEETPMVEYANVHFALETMREEAQSIGKDGPRVLLLGSENTGKTSLAKILTAYATKIGRQPLVVNLDPTEGMLGVPGTLTATAFRTILDVEDGWGSSPMSGPSPVPVKLPLVYSYPMQSPLDGEGAVYRPVVSRLALSVTGRMAEDEDARETGIIVDTPGILGTDKPGTMELINHIVTEFSITTILVLGSERLYSTVARQYDNKPTSSATAAVFDEHISVVKLSKSGGCVDRDDAFRKATRESQIRSYFFGNPIPSSSPSSAITLSPHAQQLDFASLPVYNYIVSSADDEDEDEYDPSQLGTGDSFLPGGGGMDDYASQETKQDPDRAAPLPGVVGSFSEHADNVNANANANSSSSVPLKKVLPPAPSALANTLLAITHAPTTASPAEVRDASIMGFLYVADVDVDKGKIRVLAPVGGRMPPRAIIWAKRWPGELVGLVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W6QML5</accession>
    <name>W6QML5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Alpha-hydroxy acid dehydrogenase, FMN-dependent</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PROQFM164_S07g000013</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792021">
        <property type="protein sequence ID" value="CDM37665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QML5"/>
    <dbReference type="STRING" id="1365484.W6QML5"/>
    <dbReference type="OMA" id="SLWVTVD"/>
    <dbReference type="OrthoDB" id="1925334at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012133">
        <property type="entry name" value="Alpha-hydoxy_acid_DH_FMN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037396">
        <property type="entry name" value="FMN_HAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008259">
        <property type="entry name" value="FMN_hydac_DH_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578:SF104">
        <property type="entry name" value="CYTOCHROME B2, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578">
        <property type="entry name" value="S -2-HYDROXY-ACID OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000138">
        <property type="entry name" value="Al-hdrx_acd_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00557">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51349">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0288">FMN</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN hydroxy acid dehydrogenase" evidence="6">
        <location>
            <begin position="7"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="273"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="86"/>
            <end position="88"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="271"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="276"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="307"/>
            <end position="311"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="330"/>
            <end position="331"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000138-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000138-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM37665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="395" mass="43310" checksum="695511C578E7E7CA" modified="2014-04-16" version="1">MAINKIPDSSLCVTTTDFEKVAKNVLSEKSWVYASSSANTGLSMRTNLDDWSLINFRPRILRSVDSMDTRRNILGHTSQFPFFVSAMGTLGSSHPGAEPLLVRGATRKGLHTMISTASTKPLEEIMDAHLDEQRLLGNQSPSNLSFQLYVPVDRTKAKSLIQRVKAAGYQSLWVTVDTSTLGKRTADRYLQAQENIDAGLTENARDTHGENEFAPAFGGRQVPGSVDGGLTWEDLDWISSEWGGPLVLKGVQSVEDVKLAVQYGVQGILLSNHGGRQIHSAPSSLMTLLEIRTYYPEAFDKLQVFVDGGLRDGADVLKALCLGATAVGVGRPYYYALAAYGAEGVERCTDIIAEELEITMKMLGVSSLDQLRPDMVNTSRLMNEMWRPVFGKSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W6QMU1</accession>
    <name>W6QMU1_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CoA-transferase family III</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S02g001077</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CoA-transferase III family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QMU1"/>
    <dbReference type="STRING" id="1365484.W6QMU1"/>
    <dbReference type="OMA" id="WGHIGPS"/>
    <dbReference type="OrthoDB" id="2308815at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="entry name" value="Crotonobetainyl-coa:carnitine coa-transferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052985">
        <property type="entry name" value="CoA-trans_III_biosynth/detox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48229:SF1">
        <property type="entry name" value="ALPHA METHYLACYL-COA RACEMASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48229">
        <property type="entry name" value="CAIB/BAIF FAMILY ENZYME (AFU_ORTHOLOGUE AFUA_1G05360)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="CoA-transferase family III (CaiB/BaiF)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM30927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="579" mass="63507" checksum="5DA8DD9B598DFC22" modified="2014-04-16" version="1">MPHPHKTTPSTDIYGPGSFMDTEFTPVPQDTARIFEYLAKNTPGFTQDKELWNTVKFNGSELPIIPGPIKAPLIAAALHAMCGVVAHEIVEGRDGTSARTQQVTVNTDHAAIWLGNIFAASVEGKDVPELLRSRQLSALFPQDFEHGCMSTPIKQRTTAIYKTKTPGVSYQLHGSLDPMPVLQSMGMDPNYPAKTFDEAYDYISRHVEQWTADELEMHNVKNGFCGSICFTPQGWLDTLMGKTLASHPLVGYSRQSHAIPTPPIPLPNISDDKRPLAGIKVIELVRIIAGPVIGSTLAAFGADVIRVNCSRLVDLNALQLTLNIGKRTIDIDLTKDEDKARLRELIEGADVFVQGFRPNAIARKGFGVNDLLEMAGNRGKGIVYVEENCYGSDGPYHERPGWQQIGDAASGSSYVMGRSLGHTDGLGILPPLPISDMTTGLVGAVGALMALRDRAQHGGSYRVTSSLVKADAISLEPEIGLYSPEVVERSNQLFKWDPISPAYFVAEILLIVMDGWKRVFPQYFEESGTESLMTSFQDGPFGHMTTLKPVVQLSDSSMTPRWLTPAVPYCYHPQNIEWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W6QN00</accession>
    <name>W6QN00_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF3669 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S10g000062</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792024">
        <property type="protein sequence ID" value="CDM38248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QN00"/>
    <dbReference type="OMA" id="YATLHWG"/>
    <dbReference type="OrthoDB" id="2993351at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40780">
        <property type="entry name" value="DUF3669 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40780:SF2">
        <property type="entry name" value="DUF3669 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM38248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="392" mass="44600" checksum="3081BEF36E8012B8" modified="2014-04-16" version="1">MNPRREGQSSDESATSEALSIAQNARISQQFLATNLGLLTDSAILQRTLSLNSVISTTSSFSIRFQNARSRPDLQTLNQIGAGLQGAVFEQVGKPLVLKKEFPGNEDLPSNLDHEYRIHCTVSATFEYYHSLNSEVHVPKPYNFIFKEENNAFWDEILPKIPQAYRIRGDLMMMERILPLPKVVRRALISQFYTPQYLNNTGIEAILNHPGNKHCLARVYLGKANGTIDQETPLRNFPLYLEPMEQIGIETLPLANAMGKAYATLHWAAAINGDDVEFVLGTSAIAPEGRYHEPDFQHRAVQLYLLDFGQCETVDLTQDPDIVYQAFKGAMVTGDNQRFIPHYLKSPELFAIFRKGYTEAGNRILLDKRLEDKFNMEDFMQQYEEYAEDFLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W6QN69</accession>
    <name>W6QN69_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Short-chain dehydrogenase/reductase SDR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PROQFM164_S07g000173</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792021">
        <property type="protein sequence ID" value="CDM37825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QN69"/>
    <dbReference type="STRING" id="1365484.W6QN69"/>
    <dbReference type="OMA" id="AEYMVAQ"/>
    <dbReference type="OrthoDB" id="47007at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48107">
        <property type="entry name" value="NADPH-DEPENDENT ALDEHYDE REDUCTASE-LIKE PROTEIN, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48107:SF7">
        <property type="entry name" value="RE15974P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDM37825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="245" mass="25573" checksum="1691F853C72970BA" modified="2014-04-16" version="1">MSLSGKVVLITGSSKGIGKATVLRLASEGASVIINYLSDEAAANNLVAQIGPDRALAVQADASNLSDLDRLVDSAVAKFGKIDILIPNAGILPMKDLENTTEADFDNAYNLMVKGPYFLAQKATKHMPSGGRVIFISTGITALSSVAPAYLLYASAKGAINQMARVMAKDLARKNIIVNAVAPGPTTTELFLKGKSEQVLNAVAGFSPFGRIGKPEEIANVIAFLCGEDSSWMSGQIVQVNGGMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W6QNF4</accession>
    <name>W6QNF4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid/polyamine transporter I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PROQFM164_S04g000530</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QNF4"/>
    <dbReference type="STRING" id="1365484.W6QNF4"/>
    <dbReference type="OMA" id="IAGCSYT"/>
    <dbReference type="OrthoDB" id="3257095at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF2">
        <property type="entry name" value="ACID PERMEASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="131"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="202"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="244"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="283"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="327"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="378"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="412"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="456"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="489"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM35649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="526" mass="57193" checksum="224961297259A745" modified="2014-04-16" version="1">MGRENGIMLKVQHSTPETSSLDLPSQKAGTVQDKQDMWRAGRDQELNRNFRFLSVLGFTAVLMCTWEAVLFGSSYGLTNGGKGGMIYTYLGGLAGFSFVILSMAEMASMAPLSGGQYHWVSEFAPPSSQALLSYITGWICVLGWHTGIAGCCYTVANMMVGVVAINYPDTYTYEPWHVTLLVIAVALVALMFNTFLAQKLPLIEGIILIVHCFGFFGILIPLWVLSPKVPASEVFGSIEDRGGWGNNGLSCMAGLVGPIYALIEGPDSAVHMAEEIRDASRVLPMGMVWTLILNGSTGLVMIITFAFCVGDIDAVLESETGFPFIQVFLNATGSVSAATGMTVVIMTMQFCAAISNVATTSRQIYSFARDKGLPFSNFLAQVNPTFTVPLNALCVSLVIVSLLSLINIGSSVAFNAIMSLGTAALLSSYIISITCVRLRRWRNQPLPPARWSMGKFTPICDTISIMVLLVIWIFSFFPLTKDVDPTTMNWSVAIFGGVVAASLGYYVIYARRVYKGPVIRVRMLQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W6QNM0</accession>
    <name>W6QNM0_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Mitochondrial inner membrane translocase subunit Tim17/Tim22/Tim23/peroxisomal protein PMP24</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PROQFM164_S06g000518</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Tim17/Tim22/Tim23 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792020">
        <property type="protein sequence ID" value="CDM37556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QNM0"/>
    <dbReference type="STRING" id="1365484.W6QNM0"/>
    <dbReference type="OMA" id="FDCTFQY"/>
    <dbReference type="OrthoDB" id="2261329at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10485:SF0">
        <property type="entry name" value="AT05822P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10485">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM-17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02466">
        <property type="entry name" value="Tim17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="112"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDM37556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="154" mass="16393" checksum="22E542702AD6DC09" modified="2014-04-16" version="1">MDHSRDPCPWVALSDFGGAFCMGAIGGAVWHGVKGFRNSPYGERRIGALTAIKARAPVLGGNFGCWGGLFSIYDCSIKGIRKKEDPYNAIIAGFFTGGSLAIRGGYKAARNSAIMCAVFLAVIEGVGIGFQRMMADNTKLELPPPPPSEYKAML</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W6QNV5</accession>
    <name>W6QNV5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="8">N amino acid transport system protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">mtr</name>
        <name evidence="8" type="ORF">PROQFM164_S07g000004</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792021">
        <property type="protein sequence ID" value="CDM37656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QNV5"/>
    <dbReference type="STRING" id="1365484.W6QNV5"/>
    <dbReference type="OMA" id="DAGRLMF"/>
    <dbReference type="OrthoDB" id="655540at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF8">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="141"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="203"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="244"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="283"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="324"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="368"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="397"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="430"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="7">
        <location>
            <begin position="57"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM37656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="477" mass="51340" checksum="92348FD97C82CAFC" modified="2014-04-16" version="1">MGFENISNDHDTDKVMETEGEKAAYAPPPPFEGDMVGEMSEAERNLYDHGINKFNRLGWKRLTVVLIVEAIALGSLSVPSTFATLGMVAGVICCVGIGLIAIYTSYIVGMVKLAFPEVANYADAGRLLGHRLGCGRFAYELVNAMLGLQLIFLTASHCLTGTIAFLDITKSGICSIIFAVVSAVILLLLAIPPSFTEVAILGYVDFVSIIAAIGITIIGTGVQATNSPGGLSGVAWSAWPKDNISFTEAFIAVTNIIFAYSFAMCQFSFMDEMHTPRDFIKSIWTLGITEIVIYTITGATIYAFVGQDVSSPALTSAGTTLSRIAYGIALPVIFISGSINTVVFGRVVHGRIFANSPIRFINTKMGWLTWLAVITAATVVAFIIAEVIPFFNDLLSISSALFISGFTFYFPAMMWFMLLRKGSWKEPKNLILAVINALIFLIGMVVLAGGTYSSIDDIIIKYAKGEVRGVFSCGAPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W6QP42</accession>
    <name>W6QP42_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S09g000101</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792023">
        <property type="protein sequence ID" value="CDM38185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QP42"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM38185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="181" mass="20283" checksum="2D62225CC4933522" modified="2014-04-16" version="1">MLQRYRCELCCLGGKTQAEASHKITDCPSSNAEVVNQQVLNLVNFISAKISAGQQYPYCTECLLPFSVCRDLPKELQQQGCRSEGCSIPGVVMNAMISIAEIRQDIGDKIQALFEAETSQLSNPDLFSWFLEVTKDTDRDLIPRITQLFTEFCPEVVIGSSPQRVLDIISPPRRVQRPRNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W6QP43</accession>
    <name>W6QP43_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Scramblase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S04g000740</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phospholipid scramblase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QP43"/>
    <dbReference type="STRING" id="1365484.W6QP43"/>
    <dbReference type="OMA" id="MIGFEQA"/>
    <dbReference type="OrthoDB" id="191150at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017128">
        <property type="term" value="F:phospholipid scramblase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005552">
        <property type="entry name" value="Scramblase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23248:SF9">
        <property type="entry name" value="PHOSPHOLIPID SCRAMBLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23248">
        <property type="entry name" value="PHOSPHOLIPID SCRAMBLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03803">
        <property type="entry name" value="Scramblase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="30"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="474"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="34"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="54"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="507"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM35859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="531" mass="58168" checksum="9B64B274F161272F" modified="2014-04-16" version="1">MELLLTNFHPINLLPQSLSWTPARTRAFSSFRSHGSRRGPRNSIRRPNLIQTSRKAEPSHKNEPATSESQGGTSPNYDPSQNTLLSPVYVPEDPTGVLKETHPAVSILANSGIVVQRELEMMNVLIGFEQANKYVIMDAQGNHIGYMAEQDKGLVNTLARQWFRTHRSFVTHVFDRQQNEVLRFNRPFSWINSYIHVYNPLDQTPNAYSASTSLQGTAPGALIQPGNLSSARISPLDLGQMRVIGEAQQQWAPLRRKYNLFTHQQSPNSETDMGTRNFSLSDSGLSRAQQMQLIRTPDQQQGQFNQFAYVDEPFLSWDFSLKSADDQLIGSVNRNFAGFAREIFTDTGVYAMRMDSAALGTETSHDKKTLGMTLDQRAVMLATAVSIDFDYFSRHQRGLGIFDFPPYGFNMGGQAPAEGAAAEGATAGEAGAVGGVAPGTLERARTAGDVPNGMVSGATTAGAMAGYEAMQRANTTDPNAPASEPVDPASQGFEDQPQDPWGKDSPWGEEDSWGENDFWGDDSSWGDGGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W6QPW1</accession>
    <name>W6QPW1_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA-directed RNA polymerase III subunit RPC6</fullName>
            <shortName evidence="6">RNA polymerase III subunit C6</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PROQFM164_S04g001005</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the eukaryotic RPC34/RPC39 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM36124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QPW1"/>
    <dbReference type="STRING" id="1365484.W6QPW1"/>
    <dbReference type="OMA" id="VGTTKKC"/>
    <dbReference type="OrthoDB" id="613763at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006383">
        <property type="term" value="P:transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000116">
        <property type="entry name" value="DNA-directed RNA polymerase III subunit RPC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007832">
        <property type="entry name" value="RNA_pol_Rpc34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016049">
        <property type="entry name" value="RNA_pol_Rpc34-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12780">
        <property type="entry name" value="RNA POLYMERASE III DNA DIRECTED , 39KD SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05158">
        <property type="entry name" value="RNA_pol_Rpc34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028763">
        <property type="entry name" value="RNA_pol_Rpc34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 6" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0804">Transcription</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR028763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM36124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="350" mass="39044" checksum="6DAC5C0C89DEF488" modified="2014-04-16" version="1">MASAGSQVAELASKLYDACVNEFDPDHLFYQNDFLNLKVIPKNDVALLLECTQSLVNQNLFRLLQKDGKLTWKLIDREDAEKLRNLTPDEAMVYNVIHSTERTGIWVRHIGNRTNLHKSILDRCLKSLEGKNYIKSLHNVKYPSRKMYMLAGLAPSEEVTGGAWFTDGVLDANFINSVAGYIEYTVSRKSWYEVPASDRKKRIKTASGKVDVKTDEKTYLPYPHGYAGYPTVAQIASAVNESGITPVRLGEESVVQLLEMLCYDNKLVALGNGEWYRSLKSPDAVKANQSRKPPIEGDDLSVANKHLVKNGMTEAPCGQCPVFRLCAPGGAVSPETCEYFDPWLNNGLGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W6QQ13</accession>
    <name>W6QQ13_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7703 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S15g000004</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792029">
        <property type="protein sequence ID" value="CDM38540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QQ13"/>
    <dbReference type="STRING" id="1365484.W6QQ13"/>
    <dbReference type="OMA" id="VEVIAMF"/>
    <dbReference type="OrthoDB" id="405906at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056120">
        <property type="entry name" value="DUF7703"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37013:SF3">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_1G05950)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37013">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_1G05950)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24802">
        <property type="entry name" value="DUF7703"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="156"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7703" evidence="3">
        <location>
            <begin position="34"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7703" evidence="3">
        <location>
            <begin position="119"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="328"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="332"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM38540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="365" mass="41097" checksum="F55281ABA616DF96" modified="2014-04-16" version="1">MDTVMTSLPPQVGAILMENISIGILVHTLPAMARFISQASNLPTAIPFMIGWYAMVTSQAVVLYSRLHLVISDTRKVRDARFARPAAIFDQVQSTGFYIQDFIISGIYIYKAARACSTRMIITNAYILYIPMTVLFFGLNYSDTRFAHPTAIFDRVQSTGFCIQDFIISGIYIYKAARAFKIIITLRSRDSRNAIIHLLYINILVVILNVLLLLTEYKLHYVQVSFKTVVYSIKLKLEFSVLNRLQLLVHTNPYVYQRGPEGQRRPSDRNIFGKVSSRSLAAPDVRVQPSITEEELPRHSLQPGNIHGYHKALRQISSDSIILPEDASYSGTLSEGHSSTPSSSSSETLPRLELTLSQFSPRLNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W6QQ82</accession>
    <name>W6QQ82_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 11">V-type proton ATPase subunit F</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">vma7</name>
        <name evidence="12" type="ORF">PROQFM164_S02g001843</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 11">Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d, e, f and VOA1).</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Vacuole membrane</location>
            <topology evidence="8">Peripheral membrane protein</topology>
            <orientation evidence="8">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the V-ATPase F subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QQ82"/>
    <dbReference type="STRING" id="1365484.W6QQ82"/>
    <dbReference type="OMA" id="IIICQHI"/>
    <dbReference type="OrthoDB" id="10261947at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033180">
        <property type="term" value="C:proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10580:FF:000002">
        <property type="entry name" value="V-type proton ATPase subunit F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10580">
        <property type="entry name" value="ATPase, V1 complex, subunit F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008218">
        <property type="entry name" value="ATPase_V1-cplx_f_g_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005772">
        <property type="entry name" value="ATPase_V1-cplx_fsu_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036906">
        <property type="entry name" value="ATPase_V1_fsu_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01101">
        <property type="entry name" value="V_ATP_synt_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13861:SF2">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13861">
        <property type="entry name" value="VACUOLAR ATP SYNTHASE SUBUNIT F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01990">
        <property type="entry name" value="ATP-synt_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015945">
        <property type="entry name" value="ATPase_V1_F_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159468">
        <property type="entry name" value="AtpF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="6 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <keyword evidence="4" id="KW-0926">Vacuole</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00046254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR015945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDM31692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="124" mass="13875" checksum="F497FA732181A4AB" modified="2014-04-16" version="1">MAVSAATYKERQFLAVIGDEDSVTGLLLAGIGHVTEPPGSQRNFLVVDSKTETSEIEQAFQNFTQERKDIAVLLINQHIAERIRHSVDAFADPFPAVLEIPSKDHPYDPEKDSVLKRVRRLFGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W6QQP8</accession>
    <name>W6QQP8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Probable transposable element</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S05g000237</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QQP8"/>
    <dbReference type="STRING" id="1365484.W6QQP8"/>
    <dbReference type="OMA" id="TTAKWTY"/>
    <dbReference type="OrthoDB" id="5151590at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="176"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM36404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="192" mass="21329" checksum="196CFE9B859D6314" modified="2014-04-16" version="1">MGPEGLDKPEIPDKPEKRSRRRGAELDPFLRTRLCVLRTTAKWTYKQIQNEYPHIPLSTIKSTILRESNRVNNHSQARSGRPSKLKDEDRARIREAFHANPQITYDELLVVVDYKVGKESLRRFLNDDGLRKTQTPARSSLAGKGATKKVDGAQSVQSYDTPSADWAGDLASGLVPSDSDPASATASQVVSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W6QQR5</accession>
    <name>W6QQR5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S02g002043</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QQR5"/>
    <dbReference type="STRING" id="1365484.W6QQR5"/>
    <dbReference type="OMA" id="QHIGRLM"/>
    <dbReference type="OrthoDB" id="5332870at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23159">
        <property type="entry name" value="CENTROSOMAL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23159:SF60">
        <property type="entry name" value="SPINDLE ASSEMBLY ABNORMAL PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="883"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="928"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="568"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="699"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="837"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="946"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="986"/>
            <end position="1013"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM31892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="1049" mass="117373" checksum="8DD4F33143D14C8B" modified="2014-04-16" version="1">MAEQLAQLVREVERLITTPYVPSLQDLHDLVQHTKSSTIGTWALCKRCQVGLLADVLIEALSRSRVALPLITAFASTSSSFRDALLERHPVILDAFLEKAVDTNGDEYLPACIALFSSPLPASVVPPARIAPFITKLVSLMAANLCVKTVAPLHAFISGLKGSSRILNDIPSEVMSNLQLEFTKTLRNLDDHMGNLLCLATFAQIATALDTKSQNQHGSETPWLLSIKHFFGQKRGLKTLDLVVLRVILACSSSCNLTPFEATESIRLAICIADAIEPEQKQAWMAGNNPKIAKLCEKAVRDVPYSQTQTMVIVFLHTLLPAHSLPSQLREVGIKVLLSKNSQQTMETIPHQLIPRLAKSLAESGEHATRQLLAFTFDVLRGGKCAGAEIPTLHLANLVLAGVQEVHTDIMLSNVKHSMVPMREVLRETVDYFPRQPSESQCSGRACCTSELYTRQNRLFLSLLGLYNMASAQNGSDIIMKTFIRRVEQSMPSLDCAFSTTTPKTFRGSFALRDRHELPSTQVNRNWRSGVTELFMQNAQTSHDNMMRKIEDTCFDLERRCHDVEGPLRATEEERDRYASENEQLKRQNEEFNERLKSETTEMETKLRNSHDSFVELGHENTRLEQLLQGQYSYTEELTMSLNSAREELQYQQQSSENALHIEKEKARSKELEMIATITGKDDQLEDLQQELCSLQMKNEETRQSLDQMSSEKATLSQLSSSLEQELASAREALKQARLLVDEKEDQVNRFVAQEEELRKKLGSAETTVAQQNLEVERLYSELEESDEKSRSEIEKLKHDLEAGASRATSEIAKHETENRRLHAAMQAAALDASRDVQSKDKRIQHLERKVQALRDERAAKAREFSEAQQHIGRLMGVMGFSANAPESNAPAKHQRTRSSVNATPAARIPQPISDDEDGIQLAQSFESITSSFNGPTPKRPRGNRKSTNQPYALNTTGSKAKSPPPAIAISRSVRKPLAEADRNSPTKSQPSSGSKRNQVDDSFQETQAQGNPEENRLHDLDLDMDLEFSKDFLFSSTAFTESTDRIAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W6QRJ0</accession>
    <name>W6QRJ0_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Inorganic polyphosphate/ATP-NAD kinase, predicted</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PROQFM164_S02g002313</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAD kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QRJ0"/>
    <dbReference type="STRING" id="1365484.W6QRJ0"/>
    <dbReference type="OMA" id="EHMLKYW"/>
    <dbReference type="OrthoDB" id="24581at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019674">
        <property type="term" value="P:NAD+ metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006741">
        <property type="term" value="P:NADP+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.30:FF:000005">
        <property type="entry name" value="NAD+ kinase Utr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10330:FF:000025">
        <property type="entry name" value="NAD+ kinase Utr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.30">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00361">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017437">
        <property type="entry name" value="ATP-NAD_kinase_PpnK-typ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002504">
        <property type="entry name" value="NADK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20275">
        <property type="entry name" value="NAD KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20275:SF0">
        <property type="entry name" value="NAD KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01513">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20143">
        <property type="entry name" value="NAD_kinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="119"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="587"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="12"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM32162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="619" mass="68314" checksum="0FE15B786BB71B64" modified="2014-04-16" version="1">MASSRDHLRSDTLPSLSTARTSPPSLSSPPRPALLRDALSIESLSQTKPDLPGPDNVLPIHVSESVQEAALSLPYSTLQQFRKSTSRRSKKALSTDCIPRQTILKALASRATIITNNTDMSGSVSSMLANKSAQTSPPSENRPRRGSNDSPQNISTALSNFQLSGYLDRSPAAARLILQSPCYFHQRFDDAVNIKKVLEEIADDEWLSHSRLVQTATGVREVSKQLQRRPIKRAVRNVMIVTKARDNSLVLLTREVAEWLLSTARYGSELGVNVYVDAKLRNSKRFDAPGLLQKDPMFAQMLHFWTPDLCWTSPDKFDLVLTLGGDGTVLFTSWLFQRVVPPVLCFSLGSLGFLTNFEFADYKSQLNAVMGEVGMRVNLRMRFTCTVYRKDRSKGAELGAVEEGEQFEVLNELVIDRGPSPYVSNLELYADDELLTVVQADGCIFSTPTGSTAYSLSAGGSLMHPSIPGILLTPICPHTLSFRPMVLSDSHLLRIAVPKSSRSTAYCSFDGKGRVELRQGDYVTVEASQYPFPTVVSNNNEWFISVQRALRWNTRGAVQKSWDGGEAEAEVNTDPNEDEQWDIDMDTVLAGPDSGIGPSEDGDALSPSPMRRQMSLLNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W6QRU3</accession>
    <name>W6QRU3_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type DNA-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PROQFM164_S05g000612</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QRU3"/>
    <dbReference type="STRING" id="1365484.W6QRU3"/>
    <dbReference type="OMA" id="FAQSDCH"/>
    <dbReference type="OrthoDB" id="2015447at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF7">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="64"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="67"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="126"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM36779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="664" mass="75902" checksum="3F7D6B16D8F5DDC8" modified="2014-04-16" version="1">MGPSGNRTNSLAFAKNDCHTCAALKEGCDRQRPRCGTCISNRRACGGFAMDLVWKELPVVNHGPLPRGRESGCSSKRDPQHTFKFTQGRPKRRRKPRQSNTVYQSILDLGLDDSLRHDGANFLNTTGKASLSFPSTPQPSSPEELGISKDCSSQSNEYMIYQLQNETHLSPGWEMGLGTMEYVDGNPIDASCPDTIEQAQLPTQLTLDPDQETSPGIIGNLNQAGGDLAEELFPMTNLESLSNWATEQDTDNPVLEEDMQPIYPIKYRNLAHKYEPILAIYDEKFCVMPLTRDCRINPFRAQTGSLENYDFLLHAIVALSFHHLSKMNNTDDLILEMHHHRSTALHLFSHALSQPTSLPLLDTLLILVSIEVCQSAFGAWGVHLNGAQKLITERKDMERGFCDSRMRAQLAMLIWWDTTIALMSRTEPRLPFSLLERLRGFDDSDGWSCFGLNGCPFELISIMARLAKLACIYQRTIQMEWTIFNFRPVRTIIAEVKGYVNKEKVEWDELNDLSEDFNLRRNRYYCIEAWRHAILLYIYRVFTKKPDDRELRMIDYFSRVILDCVRCMPCSDTTQKQVLLPVFLAAAEVGDENTRSMVREYCNHWRDVSRIYHFETASSLLDSIWKDWDPSTRSSYWWGLKVGPQDWMTGDVKGQSLVFELLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W6QS34</accession>
    <name>W6QS34_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Dolichyl-diphosphooligosaccharide-protein glycosyltransferase subunit OST5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PROQFM164_S05g000757</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the oligosaccharyltransferase (OST) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the OST5 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QS34"/>
    <dbReference type="STRING" id="1365484.W6QS34"/>
    <dbReference type="OMA" id="FMICAAG"/>
    <dbReference type="OrthoDB" id="5371169at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007915">
        <property type="entry name" value="TMEM258/Ost5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05251">
        <property type="entry name" value="Ost5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="51"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM36924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="77" mass="7965" checksum="8A94C978B700794A" modified="2014-04-16" version="1">MSLNEVWEAASATPFIPLIAKDSQFSVGFNLLLLALVTATLFGLNRSFLGIVSLGIPAALASGFGAVFMICAAGVYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W6QWI8</accession>
    <name>W6QWI8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PROQFM164_S03g000606</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QWI8"/>
    <dbReference type="STRING" id="1365484.W6QWI8"/>
    <dbReference type="OMA" id="GNYFMRY"/>
    <dbReference type="OrthoDB" id="3066029at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000354">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF64">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G11760)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="76"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="202"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="233"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="292"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="333"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="375"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="408"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="447"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="471"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="78"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="505"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM33882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="526" mass="58014" checksum="8922217E842DF2F6" modified="2014-04-16" version="1">MSPTTSKASSEDRRSQSWANETEIQRSQSRRSQREGAVNSLDHVQSHVSHHDMVVNDDFQEVNAEQYLRFSPARKVIIVGILSFCSFLAPISSTSILAGIPEVAKTYNTTGSVINASNALYMAFMGIAAPFWGPFSQVWGRRPVFLVSAFLFFAFSIGTALAPNLPAYYIFRVLTAFQGTSFLVVGSSALGDVYEPRARATALGWFLSGTLVGPAFGPFIGGVIVTFRSWRAIFWLQAALGGCGTLLVFFFFPETYPNLTKGDIADKTTWQKAKYLWHRISPLQVAIMLFKYPNLFCTGLAAGALVWNQYSLLTPIRYVLNPRFHLTSPIETGLFYIAPGCGYLVGTLMGGRWADHTVKKWIRKRGGVRVPEDRLKSCLIFLGVVIPGCILIYGWTVDKAVGGIPVPVLAMFFQGVAQLFCFPSLNTYSLDVMQSSGRSAEVVAGSYLSRYVFGALGSGLVLPAIESMGVGWFSTISALFLIVSGVGVWLTTVFGDQWRDKVEKRDQRKVEESTKEIQQETKKAET</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W6QWW0</accession>
    <name>W6QWW0_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SMAD/FHA domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PROQFM164_S03g000736</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QWW0"/>
    <dbReference type="STRING" id="1365484.W6QWW0"/>
    <dbReference type="OMA" id="VEHAGFM"/>
    <dbReference type="OrthoDB" id="687730at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051176">
        <property type="entry name" value="Cent_Immune-Sig_Mod"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15715">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 170 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15715:SF46">
        <property type="entry name" value="TO VACUOLE TARGETING VPS64, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G02420)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="734"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="domain" description="FHA" evidence="4">
        <location>
            <begin position="193"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="409"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="550"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="655"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="501"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="81"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="99"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="444"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="482"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="575"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="655"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="678"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="695"/>
            <end position="709"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDM34012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="762" mass="83082" checksum="B24347A0A1AFB991" modified="2014-04-16" version="1">MTAVASPPSVESGSRLGWYSSSNGGEGALSSANADDVSRMFMPRKHIQRSNSSSSLGSNSSVSSASTVTTPSQDTHAAQNSASESETWSSSKKKYSKNIWPSSKSEPVSGVTNARSQAVPAFSSGPSASSTMSAMHQPLNIVPSQQMPQSSQQNGVRAPTGPPSENLAILILLPMNGTFDRKQINVPYYPDVLRIGRQTNAKTVPTPLNGFFDSKVLSRQHAEVWADKSGKIWIRDVKSSNGTFVNGHRLSPENRESEPHELRESDTLELGIDIVSEDQSTIVHHKVSSKVEHAGTYGTTPSILDLNFGDLDPASGGGLLPSPLSQPLSHTRGRAGSNASSRIAQSVASNQLNALHQQRQMNYWNSPISIEQVVKRLTGELKSAKQQTTDLSQADEFLTTIMKPGYAEKEKLIKPSPLENSSHRQMNGRPKMPRVDSFSRFSDPPAPPPQQPLPEKPDALSRSTSEPFSPLKRSDTEKPKSGTGSPVSRDSSQILNLIEALSSAKREIETHGTRVKELENLLFQEQAARKLAEDKVNELEMRSLDVEVKVENGIVPPPENGVDRKGEQDDPEATVQVNGTHPSETPAPDNSQADAPVEDKTAELQTRLEIMMEEMAEMRKQMAFFKDRAEKAEDETTESRKSLNEMIETLRQERAEKASATALDKKTDTHDCEPSNGLAEQSLTSDDIPTDSKTKTPSMQGSDSVTSQNKDMDAATAATAFATQRHRYNYVQEASPYASMFGVVLLGVGLMAYLNSWQKIDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>W6R157</accession>
    <name>W6R157_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">glutamate synthase (NADH)</fullName>
            <ecNumber evidence="18">1.4.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">PROQFM164_S04g000448</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>2 L-glutamate + NAD(+) = L-glutamine + 2-oxoglutarate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13753"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="1.4.1.14"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="21">
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </cofactor>
        <text evidence="21">Binds 1 [3Fe-4S] cluster.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Amino-acid biosynthesis; L-glutamate biosynthesis via GLT pathway; L-glutamate from 2-oxoglutarate and L-glutamine (NAD(+) route): step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Energy metabolism; nitrogen metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Nitrogen metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the glutamate synthase family.</text>
    </comment>
    <dbReference type="EC" id="1.4.1.14" evidence="18"/>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1365484.W6R157"/>
    <dbReference type="OMA" id="WDGPAAM"/>
    <dbReference type="OrthoDB" id="4327079at2759"/>
    <dbReference type="UniPathway" id="UPA00045"/>
    <dbReference type="UniPathway" id="UPA00634">
        <property type="reaction ID" value="UER00690"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051538">
        <property type="term" value="F:3 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016040">
        <property type="term" value="F:glutamate synthase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016639">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097054">
        <property type="term" value="P:L-glutamate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00982">
        <property type="entry name" value="gltB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00713">
        <property type="entry name" value="GltS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02808">
        <property type="entry name" value="GltS_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000160">
        <property type="entry name" value="Glutamate synthase (NADPH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1060.10:FF:000006">
        <property type="entry name" value="Glutamate synthase (NADPH/NADH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000031">
        <property type="entry name" value="Glutamate synthase 1 [NADH]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000113">
        <property type="entry name" value="Glutamate synthase [NADH], amyloplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000022">
        <property type="entry name" value="Glutamate synthase [NADH], amyloplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.60:FF:000001">
        <property type="entry name" value="Glutamate synthase, large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000001">
        <property type="entry name" value="Glutamate synthase, large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000314">
        <property type="entry name" value="Uncharacterized protein, isoform E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="entry name" value="Alpha-helical ferredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.60">
        <property type="entry name" value="Glutamate synthase, alpha subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028261">
        <property type="entry name" value="DPD_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002489">
        <property type="entry name" value="Glu_synth_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036485">
        <property type="entry name" value="Glu_synth_asu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006982">
        <property type="entry name" value="Glu_synth_centr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012220">
        <property type="entry name" value="Glu_synth_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002932">
        <property type="entry name" value="Glu_synthdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006005">
        <property type="entry name" value="Glut_synth_ssu1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051394">
        <property type="entry name" value="Glutamate_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01317">
        <property type="entry name" value="GOGAT_sm_gam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008730">
        <property type="entry name" value="PRK11750.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43100">
        <property type="entry name" value="GLUTAMATE SYNTHASE [NADPH] SMALL CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43100:SF1">
        <property type="entry name" value="GLUTAMATE SYNTHASE [NADPH] SMALL CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14691">
        <property type="entry name" value="Fer4_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00310">
        <property type="entry name" value="GATase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04898">
        <property type="entry name" value="Glu_syn_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01645">
        <property type="entry name" value="Glu_synthase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01493">
        <property type="entry name" value="GXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000187">
        <property type="entry name" value="GOGAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00419">
        <property type="entry name" value="ADXRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69336">
        <property type="entry name" value="Alpha subunit of glutamate synthase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46548">
        <property type="entry name" value="alpha-helical ferredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51971">
        <property type="entry name" value="Nucleotide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="17 21" id="KW-0003">3Fe-4S</keyword>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0274">FAD</keyword>
    <keyword evidence="8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-0288">FMN</keyword>
    <keyword evidence="16" id="KW-0314">Glutamate biosynthesis</keyword>
    <keyword evidence="12" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="14" id="KW-0408">Iron</keyword>
    <keyword evidence="15 21" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="23">
        <location>
            <begin position="53"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="960"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="active site" description="For GATase activity" evidence="20">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="1210"/>
        </location>
        <ligand>
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="1216"/>
        </location>
        <ligand>
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="1221"/>
        </location>
        <ligand>
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00009716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00024383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR000187-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PIRSR" id="PIRSR000187-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="CDM35567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="2148" mass="236342" checksum="1E466E88B300E75B" modified="2014-04-16" version="1">MGLNLEELYGKDISEEQAPHEYSQYQPKKGFGWANALPERQGLYDPEYEKDACGVGFAAHIKGKASHKIVSDARNLLCNMTHRGAVGSDARDGDGAGVMTSIPHKFFIKNFAREVGVDLPPLGQYAVGNLFFKPDEEALKQSIADFEELATSLGLRVLGWREVPRDSTILGPAALSREPIIMQPFVVLKSAYGEGNKPEITDTEIFDERTFELQLFVLRKRATHVIGLGNWFYLCSLSNRNIVYKGQLSPVQVYTYYHDLVNVDYEGHFALVHSRFSTNTFPSWDRAQPLRWAAHNGEINTLRGNKNWMRAREGVLRSEVFGDELDKLYPIVEDGGSDSAAFDNVLELLMINGVLSLPEAVMIMIPEAWQDNPAMDPAKSAFYEWAACQMEPWDGPALFTFSDGRYCGANLDRNGLRPCRFYVMDDDRIVCASEVGAIEIDPERVVQKGRLQPGKMLLVDTVAGRIIDDAELKQTVARRQDFAGWLDKGLLKLPAINQVLLDSNVDLSFALDDNTIQNDPRLRAFGFSFEQVSLILGPMAADSKEALGSMGNDAPLACIAQQPRLLYEYFRQLFAQVTNPPIDPIREAVVMSLECYVGPQGNLLEMDPSQCHRLRLPSPILSIPEFNALKNVNIAHNDWTVRTIDITFEKGKGTAGYIEALDSICDSATEAIQNGDKLIILSDRATSADRVAVSALLATGLVHHHLVRNKWRSLAALAVETAEAREVHHHCVLLGYGADAINPYLALECILKMNRENLIRKDISDEKVIQNYKSSCDGGILKVMSKMGISTLQSYKGAQIFEALGIDDSVIDRCFSGTASRIRGITFDLIAQDAFAFHERGYPSHPIVEVPGLPESGEYHWRDGGEAHINDPTSIANVQDAVRTKNDKSYEAYAKSAHEQIKNCTLRGMLDFDFDQRTPIPIDQVEPWTEIVRRFVTGAMSYGSISMESHSTIAIAMNRLGGKSNTGEGGEDAERSKRMENGDTMRSAIKQIASGRFGVTSNYLADADELQIKMAQGAKPGEGGELPGHKVVGPIARTRFSTPGVGLISPPPHHDIYSIEDLKQLIYDLKCSNPRARVSVKLVSEVGVGIVASGVAKAKADHILISGHDGGTGASRWTGIKYAGLPWELGLAETHQTLVLNDLRGRVVVQTDGQIRTGQPHQTLVLNDLRGRVVVQTDGQIRTGRDLAIACLLGAEEYGFATTPLIALGCIMMRKCHLNTCPVGIATQDPELRQKFKGTPEHVINFFYYVANEMRAIMAKLGVRSVNEMVGRAELLKIRDDIRNAKQERIDLSLILTPAHSLRPGVATYNVRKQDHRLHTRLDNKLIAESELALEKGLPCRIECDIVNTDRALGATLSYQISRRYGEAGLPQDTIHANIKGSAGQSFGAFLAPGVTLELEGDANDYVGKGLSGGRLIVYPPRGAAFKAEENVIVGNTCLYGATRGTCYFRGMAAERFAVRNSGATVVVEGVGDHGCEYMTGGRVLNLGPTGRNFAAGMSGGIAYVLDKNQDFHSKVNLEMVEISSIEDPSEIAFVRGLVEDHHHYTGSELAARILLDFTRALPHFVKVLPTDYKRVMEEEAAKAEAAKKAEFTLPQLPSTPVKTEQAKADDSKKTDLLDIEDSISDSKTDKKRSALILDKTRGFMKYSRRSEKYRNATTRTRDWGEISHRLSEDELKYQSARCMDCGVPFCQSDTGCPISNIIPKWNELVFRAQWQDALNRLLMTNNFPEFTGRVCPAPCEGSCVLGINEDPVGIKSIECAIIDRGFEMGWMVPRPPKTRSGKTVAIIGSGPAGLAAADQLNRAGHSVTVYERADRMGGLLMYGIPNMKLDKKVVQRRIDLMAAEGIKFVASTAVGPDCEVSLQSLRATNDAVIVATGATVARDLKVTGRELDGVHFAMQFLHKNTKSLLDSGLSDGEYISAKDKHVVVIGGGDTGNDCIGTSVRHGAKSVTNFELLPQPPPERARDNPWPQWPRIYRVDYGHTEVKTHMGKDPREYCVMSTEFVDDGNNHVKGINTVRVEWTKSATGGWDMKTVEGSEQFFPADLVLLSMGFLGPEDRVFGDEIELDPRKNIKTPPGYYSTNLPGVYAAGDCRRGQSLIVWGINEGRQCAREVDAFLIGTSSQLPVTGGIVRRPAIDSVPQPTEVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W6R234</accession>
    <name>W6R234_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Oxoglutarate/iron-dependent dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S04g000778</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6R234"/>
    <dbReference type="STRING" id="1365484.W6R234"/>
    <dbReference type="OMA" id="GMPYKYV"/>
    <dbReference type="OrthoDB" id="2163491at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035516">
        <property type="term" value="F:broad specificity oxidative DNA demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051747">
        <property type="term" value="F:cytosine C-5 DNA demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006307">
        <property type="term" value="P:DNA alkylation repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="entry name" value="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027450">
        <property type="entry name" value="AlkB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032852">
        <property type="entry name" value="ALKBH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31573">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31573:SF4">
        <property type="entry name" value="FE2OG DIOXYGENASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13532">
        <property type="entry name" value="2OG-FeII_Oxy_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="3">
        <location>
            <begin position="503"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="521"/>
        </location>
        <ligand>
            <name>2-oxoglutarate</name>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="643"/>
        </location>
        <ligand>
            <name>2-oxoglutarate</name>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR632852-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM35897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="686" mass="77923" checksum="5BBC472967AD01DC" modified="2014-04-16" version="1">MAPRPTVNRRQAVQRPVRTGRIAKTKKEQASKVSSDQQVAVNDQALEPVYGTPPAWSEGRQQLCDAIPWFRCTQGAMYHNEGFCYGFLIDADGGTRTYIDEEIIITRIGGCCTKDSEGNLTLEKNQDSENSLVQSIIASQNSKLAVGLVIGSKNKILNRELPHRYNIMDWFRVTNVWFEKIGKKHGVKVRFEKLNLAEKSWWAAKYSLPPVPLHGRDFETKPETLKCERCSTESIRLYEDGWMCLDPSCVDFWKIENASPPAELTFNPDFLSFRSPPDPEIQPHYSLVPDLLLTLDENAADVSTARIAWKGIVCPMCFKCIRRTFWRGWKCDDDSIGEECAKSCPFQKFMNMKPVSLRVVLDHFELAPIKRAIIFDRKFNTPEIDDKTFFPYRKLTYKLDGVGSITHFVSNKAINSRANGPDDLFINLQRDDLGLKRFQLQSSLVAGTLTSHFAVNYGMPYKYVVSVDSKGFDEAPNDMLQALGRLSWATEKAVISSGDKYLPPNELLTLGYFEEMKIGFHDDGESSLGPSIATLSLGAKATMFVRMKYKYFNGSTRRAEPRQIGTLLQNDPVLKDCMFEGERRTLKEEFDAGEISQSDYDDSRRALAMGRKGREAPVTIKMELNHGDLVVMHGEDLQKYYEHSVVPENKLRFALTARYVKPDQVDAREIQKGQFSLTPDQIYDGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>W6R5A2</accession>
    <name>W6R5A2_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Probable transposable element</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PROQFM164_S05g000835</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM164</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Component of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM37002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1365484.W6R5A2"/>
    <dbReference type="OMA" id="PLQNNAR"/>
    <dbReference type="OrthoDB" id="5857104at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17919">
        <property type="entry name" value="DEXHc_Snf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15489">
        <property type="entry name" value="PHD_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056616">
        <property type="entry name" value="Chromo_MIT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055565">
        <property type="entry name" value="DUF7141"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040934">
        <property type="entry name" value="Znf-CCCH_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041684">
        <property type="entry name" value="Znf-PHD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45623:SF17">
        <property type="entry name" value="CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45623">
        <property type="entry name" value="CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 3-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23615">
        <property type="entry name" value="Chromo_MIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23614">
        <property type="entry name" value="DUF7141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18585">
        <property type="entry name" value="zf-CCCH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15446">
        <property type="entry name" value="zf-PHD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="692"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="12">
        <location>
            <begin position="998"/>
            <end position="1147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="184"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1248"/>
            <end position="1346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1472"/>
            <end position="1512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="204"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="222"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="257"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1248"/>
            <end position="1257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="1305"/>
            <end position="1321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1472"/>
            <end position="1495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDM37002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="1512" mass="171764" checksum="633FCE6E34036B6A" modified="2014-04-16" version="1">MSQSRDNSPGSDSSDDADAVAAQLLAQFQSAPSCTPPTIPPEGPENALQPVQHITRNSKESTMSFEIIVPVVNNPDDYEYLPGHFEVHRILAVDMHEPKLIVRLKSGEVQTMTTKDLKSLKNGRKALREFNRDSQSPDPLAMDHSPIPHFIYAGGDGPADYDSDMDWGIARNRQRRAPLVSYNNFFRSDDEEDEDDYQSRREEIDSEESSDEDEDEDDPPTKRRQRRPPRRGAQRGRKQRDREWSEQSSASDTGKRVSSRLRQTRRRNMKERLEDDEYSAVEPEQPKHQKFSGAREQFRELPQDNKFRLCHSQSCTQCGHGDHDREKGSLVFCQGCTVSYHQGCLGDRTSRKHLVTKVDEGDFILQCSRCLGIKHQEHDMKPHLGHCAVCRDEGPMSQPLRETLSSQTEQHLREANGGIDPITPVDMSSVNNVDNILIRCLGGSHSCKRAFHIQHLPNTAEENLTHIDPDNWQCDECSKSPPGANPIQVIVAWKPRNPEVKVVSQLVEMIPEIDKLYLVKWHKLSYFRVTWVTGDWVWARIPASQMKAFLKSERSTKPIMTVAEAVPEDNLRVDIVFDVEYHTEPKSQEDRANAKMVERAYVKYKGLSYEDSVWEIPPEQTDTARWEDFQTALIDKVRQENVHVPKPKDLQSRLRDVRREKFDQSLLLTAQPALVTGGELMDYQMEGVNWLLYMFFKQTNAILADDMGLGKTIQVITLFAALIDKLDCFPFLVVVPNATVPNWRREIKSWSPHIRVVTYYGSAFAREMARDHEMFDENGTLCCHVVIASYESMADDGAKRVLSSINWAGLVVDEGQRLKNDKTQLYERLRRMKFGFKLLLTGTPLQNNIRELFNLVQFIDPTYNAEELEAKYAGALDREAIRELHDMIRPCLLRRTKAEVLPFLPPMVQIIIPVSMSVVQKKLYKSILQKNPQLLKAICKKQVGQLKKAERHNLNNILMQLRKCLCHPFIYNRDIEEQTLDSQLSHRRLVEASGKLTLLNLMLPRLRERGHRVLIFSQFLENLDIVEDFLTGLGLQYCRLDGNLSSREKQQQIDQFNAPKSQFFAFLLSTRSGGVGINLATADTVIIMDPDFNPKQDMQALSRAHRIGQKNTVLVFHLVVRASVEEKIMQKGKTKMALDHVLIDRIEADEDKEDLESILKHGAEALFNDDDSADITYDVDSIDKLLDRSQAEQVKKIASEGSSDQNEQTQFNFARVWQKDRGSLEEVTETEDTPVDVTAWEKILQEREREAQEEANRQAEGLGRGKRKRGTPRYNNNIVIEGVDDDENLSPRKPPSKMRKRAADNDDEFQQPEDDGDETEFESDHGAEPMDLTYDGAEPMDTANDGDRTEAQMGTTNVVTPGLHVGAGQQVARAFRCVNSPPPVTYHLDIRPCVACKQRHIPGQCPLRSAGVEFCGLCGLAHWGGRRICPHLQSRVQVSRMLDTLEESPEDPALILKAKKYLRGVLKSMGQTARSKASSATQAESRIFTSPSVSGVSRAPTDLTGASTESKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W6R6E0</accession>
    <name>W6R6E0_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">aldehyde dehydrogenase (NAD(+))</fullName>
            <ecNumber evidence="3">1.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">MSC7</name>
        <name evidence="8" type="ORF">PROQFM164_S06g000338</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>an aldehyde + NAD(+) + H2O = a carboxylate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:16185"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.3" evidence="3"/>
    <dbReference type="EMBL" id="HG792020">
        <property type="protein sequence ID" value="CDM37377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6R6E0"/>
    <dbReference type="STRING" id="1365484.W6R6E0"/>
    <dbReference type="OMA" id="ILMRGTF"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07098">
        <property type="entry name" value="ALDH_F15-22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000024">
        <property type="entry name" value="Betaine aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="7">
        <location>
            <begin position="99"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00049194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM37377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="634" mass="68640" checksum="4C2A0CCDD8D8A797" modified="2014-04-16" version="1">MGCLASHIPPSLRTLLEAYAPPGSVEYAPHVGVALTSLLAVYVGYLYIQSLREAAVVFNVPIPSEIRNSRSIKTWDEVQGLQKIVLEDQAQGKWNNELIVSYCPADGRVLGNGIKPATVEDVNEVVRVAGAAQPEWAKTTFAERRKVLRTLLKYVLDHQEDLVTACCLDSGKTKVDGSFGEILVTVEKLKWTIDHGEKALLPERRPTNFLMMYKKNTVTYEPLGVVGACVSWNYPLHNFIGPIISALFTGNAVVVKPSEQTAWSAVYFLEMVRGALSSCGHSRDLVQTLVCLPNVADAFTSHPDIAHITFIGSRPVAHHVCTSAAKSLIPVCVELGGKDPAVILDDSRTLRNLPSIASILMRGVFQSSGQNCIGVERIIALPNAYDRLIEIVTPRIQNLHLGSVLLDTATPDVGAMISPVSFANLEKLINEAVQQGARLLAGGTEHKHPVHQHGHYFTPTLLVDVTRDMRIAQTELFAPVFLMMRAESVPDAIAIANSTPYALGASVFGHQQSDVQACVSRISAGMVAINDFGAFYAVQLPFGGVRGSGYGRFAGEEGLRGLCNIKAVCVDRFPTLIGTGIPPRVDYPIQNRADAADAKGGVAAWEMCKGIVEMGYELTLGGRIAGILRLLRNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W6R7X4</accession>
    <name>W6R7X4_PENRF</name>
    <protein>
        <submittedName>
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        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S08g000008</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792022">
        <property type="protein sequence ID" value="CDM37957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6R7X4"/>
    <dbReference type="OMA" id="FGGDCWP"/>
    <dbReference type="OrthoDB" id="2093528at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015168">
        <property type="entry name" value="SsuA/THI5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09084">
        <property type="entry name" value="NMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SsuA/THI5-like" evidence="2">
        <location>
            <begin position="60"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM37957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="325" mass="36620" checksum="A1D7584E35FF7778" modified="2014-04-16" version="1">MGKNIRLTFACGPYDRMDPLANKAVDPVGIDLNYITINHPREIFDRMIRGMEFDLSEMSSSEYVCRYAAGERDLVGIPVFPSRAFRHSCIAVNSDIISSPSDLNGKRIGVQVYTMTAAVWIRGVLQDAGVDLSTITWIEGDLVKPGSHGQPKTKPLLRPVSRVPNESPKSLSQLLEEGEIAATIGAHAPPCLAKASHIRHLFPNIRETEKEYYQRTGIFPIMHLVVIKRAVVEKHPFVPRSLFQVMNESKNIALRSMRLASTYRYMLPFLSSDLEEIEQLFGGDPWPYGIESNRTVLEALVNLLYDQAMISRRISLEELFPFPCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>W6PRA7</accession>
    <name>W6PRA7_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S01g000065</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PRA7"/>
    <dbReference type="OrthoDB" id="10270475at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM26256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="66" mass="7393" checksum="468F0C499DA83037" modified="2014-04-16" version="1">MNKARQQPHRPDSQVTSGGILHVREIDGGMALDGLQDMKDDRFKNIVNIVEEDPIISLRGTCTYIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W6PRC2</accession>
    <name>W6PRC2_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Oxoglutarate/iron-dependent dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S01g000085</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PRC2"/>
    <dbReference type="STRING" id="1365484.W6PRC2"/>
    <dbReference type="OMA" id="CRLLHYF"/>
    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044283">
        <property type="term" value="P:small molecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="3">
        <location>
            <begin position="177"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM26276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="338" mass="38552" checksum="58F893349F316D73" modified="2014-04-16" version="1">MGEVPGLLRDMASETRYVDRVIPRISMHDFEDRIEEITDQLIHAAENVGFFTLINHGISKEDIQSMFAISKSFFDLSDEIKATVPWNPNNVGWEKNSQIRPSTGQPDSKESYQLQFGENMNDLWLKYDDLPGFRNACLDFMNRVQQVSECLMRCFARGLGFPERFFIECHGISRPNSQTTMRLLHYFALPEVPDGKVYHRAGAHADWDFLTLLFQGDGQDGLEICPGREVVTEFGIGDEWTKVKANTGEIVCNIGDLLMSWSDDRFKSTFHRVKASCEPEDYFGDRYSIAYFNQPCKDSLIQGPSKKYPMVTGAQFTETAMKRNFAALQERLKTVAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W6PSC3</accession>
    <name>W6PSC3_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Lysosomal cystine transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PROQFM164_S01g000937</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-cystine(out) + H(+)(out) = L-cystine(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:66172"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:35491"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:66173"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Lysosome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cystinosin family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PSC3"/>
    <dbReference type="STRING" id="1365484.W6PSC3"/>
    <dbReference type="OMA" id="WIDVIYT"/>
    <dbReference type="OrthoDB" id="75720at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015184">
        <property type="term" value="F:L-cystine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.290:FF:000016">
        <property type="entry name" value="Cystinosin homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005282">
        <property type="entry name" value="LC_transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00951">
        <property type="entry name" value="2A43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13131">
        <property type="entry name" value="CYSTINOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13131:SF5">
        <property type="entry name" value="CYSTINOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00679">
        <property type="entry name" value="CTNS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0458">Lysosome</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0769">Symport</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="127"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="161"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="196"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="238"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="266"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="279"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDM27128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="288" mass="32492" checksum="66CBFF3AD532AC9D" modified="2014-04-16" version="1">MTPQLEIFIRALSRFLGWAYMLCWSGSFYPQPITNWRRKSTVGLSIDLSTINPLGFVCYAIYTSAFLYSPVIRSQYAARHPASIEPTVRFNDFAFAAHAVVMCIIMYSQFWPFIWGFHVSRFQRVSWLMAGIFWGCVLSPLVVIVAVLAQSPDGGYDPSTWAWIDVIYSFSYVKLLITIVKYMPQVALNYKRQSTVGWNIGTILLDMAGGVLSMLQLVLDSSLQSDWSGITGNPVKLLLGNVTIFFDAIFCIQHYVLYRDTPDLKRTSGPSEQSPLLDGQDDTVGDRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W6PTV8</accession>
    <name>W6PTV8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Flavin monooxygenase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PROQFM164_S01g001015</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FMO family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PTV8"/>
    <dbReference type="STRING" id="1365484.W6PTV8"/>
    <dbReference type="OMA" id="WHYDPIP"/>
    <dbReference type="OrthoDB" id="66881at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000960">
        <property type="entry name" value="Flavin_mOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000332">
        <property type="entry name" value="FMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00370">
        <property type="entry name" value="FMOXYGENASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="54"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM27206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="477" mass="53067" checksum="094A7CE4193B2169" modified="2014-04-16" version="1">MAPRYQSVAVIGAGPSGISAVKALQEENVFQTIRLFERRGHIGGIWQYDDIPDLFPSQESPSQQDHEIPGRLPLLTSPSPEDVTSRTGIYEGLDSNVGAKVMAFTHTPFPEINSASSTRHLGRSNPTRPFGVVRKYLEDLFQDYLHLASLNTTVERVEKRDQKWTLTLRQSGHGDGNTPKDYWWEEQFDAVIVASGHYSVPFVPFVPGLSAAFARHPTVFEHSKSFRKADDYVDKRVVVVGGSVSSADLVADLHAIVKGPLELSQRGKNEALQSAWDLPNVNARPTIKEIQATTKGISVVFSDNTLLEGVDKIIFATGYKLSYPFLVPNPVTPNNRAAGFYQHIFKIGDPSLALVGQVRAAISFRVYEYQAVAVARYFAGRNAASLPTPQEQDLWEVQRLQQKGHTALFHEIKPDFKDYFDFLTDLAGPPAPGTGGYTLPPWDDRWAEQGFEILQRKDKYWKSLRRAADGLGVTAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W6PU11</accession>
    <name>W6PU11_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cyclin PHO80-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g001050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PU11"/>
    <dbReference type="STRING" id="1365484.W6PU11"/>
    <dbReference type="OMA" id="PHVPKHN"/>
    <dbReference type="OrthoDB" id="286814at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20557">
        <property type="entry name" value="CYCLIN_ScPCL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615:SF36">
        <property type="entry name" value="PHO85 CYCLIN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08613">
        <property type="entry name" value="Cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="364"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="477"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="364"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="477"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM27241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="690" mass="73923" checksum="114304C438E97E10" modified="2014-04-16" version="1">MNSTVLSDMSGMDVLGLNLSNPSSQLTASHHAHPYASSISSSASSSSSSVFSLDCVSSQSSISSTSTNPVDVIWENESNSQLAGRNPNGACPRAFAKGPASKVDGVVPSELRTHPRRTNSYSSSAPSARPPPCLLRQSERKVNFVDNLVDTASQIVETIWPLSAAASRSDAATGSKGVLPLRTFIQETLRRSRTSYSTLQVALYYLIKIKPHVPTHDFTKEQPRDQSPLRAMQCGRRMFLAALILASKYLQDRNYSARAWSKISGLNTLEINQNELMFLKAVGWRLHIDEAMFQRWTDLVLKLTPGAGGPPVAKGQCWQTVLPRLTPELDYVESEPLSPVAAISGMDLGLSEYSPRSLPINESVRSLSREQTPTYARSLPRTLEPTPRMDFANLALPSIPRPMMLPTPQMTPQSQVSSTPAASVGAYNARPSICTAMSQAQNACMARSTLDQRPPLSFCPRTQSYDGYPAAARRSSLARSTSSVSSPDSMVSDVSTLSSRSSRSSSVSSNASGASGSAPPRLAVKATLRCTSNSLKESRKTLAIASPIDESCLVGVYSSPGYPSSMGSSVPDLSTFSLDSSLSEAAQSLCELSGATPERRQCRKRGRTGSDDLLLQNHVRHLINLGVSGDHCGLPDGQFPCSFMTQHGSSAVPAQIGPVSGPAGMKRACCGSEARKIALNPSLRVAEYLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W6PUA5</accession>
    <name>W6PUA5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Fumarylacetoacetase, C-terminal-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S01g001281</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAH family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PUA5"/>
    <dbReference type="STRING" id="1365484.W6PUA5"/>
    <dbReference type="OMA" id="YMHYECE"/>
    <dbReference type="OrthoDB" id="411064at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018773">
        <property type="term" value="F:acetylpyruvate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050163">
        <property type="term" value="F:oxaloacetate tautomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006107">
        <property type="term" value="P:oxaloacetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.850.10:FF:000002">
        <property type="entry name" value="2-hydroxyhepta-2,4-diene-1,7-dioate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="entry name" value="Fumarylacetoacetase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820">
        <property type="entry name" value="ACYLPYRUVASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820:SF7">
        <property type="entry name" value="ACYLPYRUVASE FAHD1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="FAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumarylacetoacetase-like C-terminal" evidence="3">
        <location>
            <begin position="82"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM27470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="294" mass="31357" checksum="0A9C1B05EE517B23" modified="2014-04-16" version="1">MSKIASTFSRLVRFVPKSNPTKVLIGEPVDPKLDVGLALYQGKEVSVRPFSGTSVLSPGQVTDATETIARILSPLAQSEVGTIRCIGLNYASHAREMGLPIPEVPTLFMKPASSLADPWPAPTVLPKITQQDNTGDYESEMVIVIGRDAKDVPKSEALDYVLGYTAANDVSSRTSQMSQSQWSFSKGFDGACPIGPVLVSAALVPDASKLQIRGLKNGNIMQNCPLTDLIFSVPQLISFLSQGTTLPAGTIILTGTPPGVGAARNPKEFFKAGDEFAVELLPHIGTLINKIEHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W6PUJ3</accession>
    <name>W6PUJ3_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PROQFM164_S01g001694</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PUJ3"/>
    <dbReference type="STRING" id="1365484.W6PUJ3"/>
    <dbReference type="OMA" id="FAWQGMQ"/>
    <dbReference type="OrthoDB" id="2017893at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008138">
        <property type="term" value="F:protein tyrosine/serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14518">
        <property type="entry name" value="DSP_fungal_YVH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000104">
        <property type="entry name" value="Dual specificity phosphatase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016278">
        <property type="entry name" value="DUSP12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45848:SF4">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45848">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE 12 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000941">
        <property type="entry name" value="DUSP12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="6">
        <location>
            <begin position="2"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="7">
        <location>
            <begin position="64"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphocysteine intermediate" evidence="5">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000941-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM27883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="351" mass="38150" checksum="85FD09897EA50E47" modified="2014-04-16" version="1">MAMNQIKGHNIYVGGILSAKNKAALARADISHVLSVLRLNPAEEMETFKSYQHLSIGLDDVDDENLLEQIPAAIKFIQSGLDGGGGVLVHCAMGKSRSAAICIAYLLHRQPAALTPQTALTLIRQSRPLCEPNDGFMEQLNLYHEMGCPDEVTDHPSYKRWLYRRDVEGSVACGRAPELKSVRFEDEQPVQSQDPTGRTVEIKCRKCRTKLATTPFIIPHEEEKKNTAKSSATADCGHVFLHPLTWMRPSLFPSEVGADAGADTTYGAHPDDAPLSGRLTCPNPVCGSNVGKFAWQGLRCSCGGWVVPAIGLTKARVDIAYQVNMARANPAIRLPPGMRALPANDSGRGNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W6PUS4</accession>
    <name>W6PUS4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S01g001451</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PUS4"/>
    <dbReference type="OrthoDB" id="4361103at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM27640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="131" mass="14554" checksum="BE750EDE4D71A085" modified="2014-04-16" version="1">MYSFSVSVSFGSSKFSFPGLSSQIPNERDQTSDSGQQKQKDETYVSQGFVIGAFLAIFFAQVGVNFLHAVRAGRRRRRFMEMQFPQPLPQRDQEQDRAFNTDPGINTNAREEGARDDAEGRPVTGNAPSVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W6PUT8</accession>
    <name>W6PUT8_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nucleotidyl transferase AbiEii/AbiGii toxin family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S01g001357</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PUT8"/>
    <dbReference type="OMA" id="FRSWSHR"/>
    <dbReference type="OrthoDB" id="5419802at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM27546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="230" mass="26326" checksum="494EF3BE3C170E29" modified="2014-04-16" version="1">MRGLLLPQLETVVSRIAQCLDLLQIDYALMGGAAVCFMAPHPSRRTEDVDLVIHVDQRYITADLLTQRLLNAFPADFGPVNQFGHVIPAFRLRSPSGTIQLIELETATRVTRTINGYPVKIFGAEWLTREKILSQYQRQGPKHLTDIEDIARLVRYCVPNRPELNFDQDAQLQLALASLLRERPRLHSSLRRSIKCNSVFGNWPSHFILIWRSWVRTIVISAYSHQQTIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>W6PV43</accession>
    <name>W6PV43_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Serine/threonine-protein kinase TOR</fullName>
            <ecNumber evidence="16">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">tor2</name>
        <name evidence="20" type="ORF">PROQFM164_S01g001477</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Associates with DNA double-strand breaks.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Vacuole membrane</location>
            <topology evidence="13">Peripheral membrane protein</topology>
            <orientation evidence="13">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the PI3/PI4-kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="16"/>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1365484.W6PV43"/>
    <dbReference type="OMA" id="MRQHSAK"/>
    <dbReference type="OrthoDB" id="381190at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031931">
        <property type="term" value="C:TORC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031932">
        <property type="term" value="C:TORC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006995">
        <property type="term" value="P:cellular response to nitrogen starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016242">
        <property type="term" value="P:negative regulation of macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905356">
        <property type="term" value="P:regulation of snRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038202">
        <property type="term" value="P:TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05169">
        <property type="entry name" value="PIKKc_TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1070.11:FF:000020">
        <property type="entry name" value="Serine/threonine-protein kinase TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.150:FF:000001">
        <property type="entry name" value="Serine/threonine-protein kinase TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000371">
        <property type="entry name" value="Serine/threonine-protein kinase TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000582">
        <property type="entry name" value="Serine/threonine-protein kinase TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1010.10:FF:000006">
        <property type="entry name" value="Serine/threonine-protein kinase TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.150">
        <property type="entry name" value="FKBP12-rapamycin binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050517">
        <property type="entry name" value="DDR_Repair_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003152">
        <property type="entry name" value="FATC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009076">
        <property type="entry name" value="FRB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036738">
        <property type="entry name" value="FRB_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057564">
        <property type="entry name" value="HEAT_ATR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058584">
        <property type="entry name" value="IMB1_TNPO1-like_TPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024585">
        <property type="entry name" value="mTOR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003151">
        <property type="entry name" value="PIK-rel_kinase_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014009">
        <property type="entry name" value="PIK_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026683">
        <property type="entry name" value="TOR_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139">
        <property type="entry name" value="ATAXIA TELANGIECTASIA MUTATED ATM -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139:SF9">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE MTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02259">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02260">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08771">
        <property type="entry name" value="FRB_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23593">
        <property type="entry name" value="HEAT_ATR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11865">
        <property type="entry name" value="mTOR_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25574">
        <property type="entry name" value="TPR_IMB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01346">
        <property type="entry name" value="DUF3385"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01343">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01345">
        <property type="entry name" value="Rapamycin_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47212">
        <property type="entry name" value="FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51189">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51190">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00915">
        <property type="entry name" value="PI3_4_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="9 16 20" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 16" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0926">Vacuole</keyword>
    <feature type="domain" description="FAT" evidence="18">
        <location>
            <begin position="1241"/>
            <end position="1812"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="17">
        <location>
            <begin position="1986"/>
            <end position="2306"/>
        </location>
    </feature>
    <feature type="domain" description="FATC" evidence="19">
        <location>
            <begin position="2349"/>
            <end position="2381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU364109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CDM27666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="2381" mass="269175" checksum="AEDB6175B06CB16D" modified="2014-04-16" version="1">MAQAGAISDVTQRLFVELKSKNEEARARAAYELYENVLSVSRDWPSEKFVEFYNAVSQRIAQLVVNGSDANERIGGLLALDRLIDFDGVDAAQKTTRFASYLRSALRSNDNAVLVYAARSLGRLAKPGGALTAELVESEIQSALEWLQSERQESRRFAAVLVIRELAKGSPTLLYGFVPQVFELVWVALRDPKVLIRETAAEAVGECFEIIVARDSQVRQSWFARIHDEALLGLKSHNVDWIHGSILIIKELILKGTMFMKEHYRDACEIILRLKDHRDPKIRTEVVLTIPILASYAPTDFTEIYLHKFMVYLQAQLKRDKERNSAFIAIGKIANAVGTAIGQYLDGIIIYIREGLAMKARNRSGVNEAPMFECISMLSLAVGQALSKYMEALLDPIFACGLSKSLTQALVDMAHYIPPIKPMIQEKLLDMLSIILCGTPFRPLGCPENRLPPMPSFAKDFAPNELHSDSDIALALHTLGSFDFSGHILNEFVRDVAINYVENDNPEIRKASALTCCQLFVHDPIINQTSGHSIQVVSEVIDKLLTVGIGDPDPEIRRTVLWSLDRKFDRHLARPENIRCLFLAVNDEVFDVKEAAICIIGRLSSVNPAYVFPPLRKLLVNLLTGLGFANTARQKEETAQLISLFVSNATKLIRSYVDPMVTALLPKTTDINPGVAATTLKAVGELANVGGHEMRQYLPQIMPIILDSLQDLSSHNKREAALRTLGQLASNSGYVIEPYMEYPHLLGVLINIIKTEQTGSLRKETIKLLGVLGALDPYKYQQISEIEPDVHHINEIQNVSDVALIMQGLTPSNEEYYPTVVIHTLMQNILRENSLAQYHSAVIDAIVTIFKTLGLKCVPFLGQIIPGFILVIRSAPASRLEPYFNQMAILVNIVRQHIRTFLPEIIEVIRDFWDASYQIQGTIISLVEAIARSLEGEFRKYLAGLIPLMLDTLDKDTSPRRQPSEKILHALLIFGTSGEEYMHLIIPSIVRLFDRPQNPQSIRKSAIDSLTKLSRQVNVSDFASLMVHSLSRVVASGDRVLRQAAMDCICALIFQLGQDFTHYIHLLNKVLKTNQIVHVNYQILVTKLQKGDPLPQDLNPEEVYTFPTDDTNFSEIGQKKIVVNQQHLKNAWDASQKSTRDDWQEWIRRFSIELLKESPSPALRACASLAGIYQPLSRDLFNAAFVSCWTELYDQYQEELVRSIEKALTSPNISPEILQILLNLAEFMEHDDKALPIDIRTLGKYAAKCHAFAKALHYKELEFEQDQNSGAVEALITINNQLQQSDAAIGILRKAQAYRDVELKETWFEKLQRWDEALAAYKRREKTDPDSFGITMGKMRCLHALGEWKVLSDLAQEKWNQASLEHRRAIAPLAAAAAWGRGQWELMDSYLGVMKEQSPDRSFFGAILAIHRNQFEEANMYIEKARNGLDTELSALLGESYNRAYNVVVRVQMLAELEEIITYKQNVGDPEKQDAMRKTWNQRLLGCQQNVEVWQRMLKVRALVTAPRENLDMSIKFANLCRKSNRMGLAERSLASLETVVSDANGTRTIAPPEVTYARLKFSWANGHQLESLEMMKEFTSGLTDDFSRYNTLMVSNAANGANGVVDQNHPDAISLNERIGDANKFRKLLSKSYLRQGEWQTTLQRGDWRPEHVREVLNAYSAATQYNRDSYKAWHSWALANFEVVTTISNQASREGMPGAVPAHIVTEHVIPAIRGFIRSIALSLTSSLQDTLRLLTLWFNHGGDHEVNTVVTEGFTAVNIDTWLAVTPQLIARINQPNIRVRGAVHRLLAEVGKAHPQALVYPLTVAMKSNVTRRSQSASNIMESMRQHSAKLVEQADLVSHELIRVAVLWHELWHEGLEEASRLYFGDNDVDGMFATLAPFHDMLDKGAETLREVSFAQAFGRDLAEAKHYCMMFRESDEIGDLNQAWDLYYTVFRKISRQLPQLSTLDLKYVSPRLKDCSDLDLAVPGTYQSGKPVIRIMSFDPILHVLQTKKRPRRMTLKGSNGSSYMYLVKGHEDIRQDERVMQLFGLCNTLLDNDSESFKRHLSVQRFPAIPLSQSSGLLGWVSNSDTFHALIKEYRESRRILLNIEHRIMLQMAPDYDSLTLMQKVEVFGYAMDNTTGKDLYRVLWLKSKSSEAWLERRTNYTRSLGVMSMVGYILGLGDRHPSNLLLDRGNGRVVHIDFGDCFEIAMHREKYPERVPFRLTRMLTFAMEVSNIEGSYRITCEAVMRVLREHKDSLMAVLEAFIHDPLINWRLGAQDSSPDRVSLTADRRQSIMDGVNFEPGAQPPGEFSRRRRPSILEGGILDAPEGVPQEAREAQNARALQVLARVKEKLTGRDFRNSEELSVSDQVDKLIAQATNVENICQHWIGWCSFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2024-10-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>W6PVD5</accession>
    <name>W6PVD5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S01g002014</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PVD5"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM28203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="60" mass="7108" checksum="6992CDE470D1F1ED" modified="2014-04-16" version="1">MLRELRDGENRVKSDEFGDRNINMKLSPYIAQDFRTHERVDPNVCQISGWCNLVNRNLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W6PVW7</accession>
    <name>W6PVW7_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Short-chain dehydrogenase/reductase SDR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S01g002174</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PVW7"/>
    <dbReference type="OMA" id="RMYTTSS"/>
    <dbReference type="OrthoDB" id="5296at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052184">
        <property type="entry name" value="SDR_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45458:SF2">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY SUPERFAMILY (AFU_ORTHOLOGUE AFUA_3G13450)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45458">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE SDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM28363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="253" mass="26801" checksum="9AFCBF0C6ADED5B0" modified="2014-04-16" version="1">MVDNILILGATRGLGASLRTLYSAKPGTHVFATSRSSNPEPSSGVTWLTGIDISQPDVGQKLVSQLPSTKLSTVIISAGYFGFETFDSPDWEKEVQMYTTSAIGPVFVVHNLVKAGLLDQGSKVILVSSESGSITLRHEKEGGGNFGHHASKAALNMVGKLLSLDLKPKGIAVGLVHPGFMRTEMTKSVGFDKYWDAGGAVTPDQAAKTLASFIEDFDLSKTGEYWAPAGPGDIGTAEVVLGKNLPTPLQLPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W6PW35</accession>
    <name>W6PW35_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Amino acid/polyamine transporter I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PROQFM164_S01g001807</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PW35"/>
    <dbReference type="STRING" id="1365484.W6PW35"/>
    <dbReference type="OMA" id="YFFDPAM"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000006">
        <property type="entry name" value="General amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF18">
        <property type="entry name" value="AMINO ACID PERMEASE_ SLC12A DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="200"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="289"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="328"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="387"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="420"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="462"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="492"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="8">
        <location>
            <begin position="58"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM27996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="555" mass="60961" checksum="CC51EFBE17B6F987" modified="2014-04-16" version="1">MSTIKTFHNDHSTDAVDEFDKDVKTMIHDPESPVQPEDEYVGDFEEISALKQGLHQRHIQMIALAGTIGTGLFLSSGRAISRSGPLGAFLGYLVMGCAAGTVTLATGEMGTLVPLNGGIVRYAEYFVDPALSFANGYNVVYSYLVSIPAEIVAAAVLVQFWSDLNSAIWISIFGVVMLCTSMAFVRVYGELEFGFSLMKILLIIGVNLMALVITCGGGPDHKTIGFEYWRHPGPFVQYLGIGGSLGRFLGVWTSMNSALYAYSGIETITVAAGETKSPRHAIPQAAKRIFFRILIFYVISIFMVGLVVPSNEPRLSSSSGTASESPFVIAATLAGIKVVPSIINAVIITSAWSSGNSNMLGGSRVLYGLAVNGKAPKFFTRLNRFSVPWVAISLYGLFMCLAYMSLSSTANTVFDWLQDLVSITTLTNWLTILVTYLRFYYGCKKQGISRKSLPWATPLQPYISWASLIMLSLLLITGGYSTFIKGQWSDEGFVSSYINIPLFFIFYFAYKLIHKTKIIPLEDIPIQPFIDIANRNPEPLPQPKKGLRKLNILWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W6PWG4</accession>
    <name>W6PWG4_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Eukaryotic translation initiation factor 6</fullName>
            <shortName evidence="5">eIF-6</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">tif6</name>
        <name evidence="5" type="synonym">TIF6</name>
        <name evidence="6" type="ORF">PROQFM164_S01g001957</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer. Associates with the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
            <location evidence="5">Nucleolus</location>
        </subcellularLocation>
        <text evidence="5">Shuttles between cytoplasm and nucleus/nucleolus.</text>
    </comment>
    <comment type="PTM">
        <text evidence="5">Phosphorylation at Ser-174 and Ser-175 promotes nuclear export.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the eIF-6 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PWG4"/>
    <dbReference type="STRING" id="1365484.W6PWG4"/>
    <dbReference type="OMA" id="WCAFCGM"/>
    <dbReference type="OrthoDB" id="4155914at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:cytosolic ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000054">
        <property type="term" value="P:ribosomal subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00527">
        <property type="entry name" value="IF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.75.10.10:FF:000001">
        <property type="entry name" value="Eukaryotic translation initiation factor 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.75.10.10">
        <property type="entry name" value="L-arginine/glycine Amidinotransferase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00032">
        <property type="entry name" value="eIF_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002769">
        <property type="entry name" value="eIF6"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00323">
        <property type="entry name" value="eIF-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10784">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01912">
        <property type="entry name" value="eIF-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006413">
        <property type="entry name" value="IF-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00654">
        <property type="entry name" value="eIF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55909">
        <property type="entry name" value="Pentein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5 6" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="3 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="modified residue" description="Phosphoserine; by CK1" evidence="5">
        <location>
            <position position="174"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphoserine; by CK1" evidence="5">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDM28146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="247" mass="26376" checksum="276948396B8AAF7B" modified="2014-04-16" version="1">MAVRAQFENSNEVGVFSCLTNAYAIVAVGASENFYSVFESELQDVIPICHATIAGTRIVGRLIVGNRKGLLVPTTTTDQELQHLRNTLPAEVKIQRIEERLSALGNVICCNDHVAIVHPDLERETEEIIADVLGVEVFRQTVADNVLTGSYMALSNQGGIVHPKTSIRDQDELSSLLQVPLVAGSVNRGSPVVGAGMVVNDWLAITGLDTTATELSVIESVFRLGEMAPGGAAGAGVNKDSIVESFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>W6PXG7</accession>
    <name>W6PXG7_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Aspartyl-tRNA synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">aspS</name>
        <name evidence="8" type="ORF">PROQFM164_S01g000463</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PXG7"/>
    <dbReference type="STRING" id="1365484.W6PXG7"/>
    <dbReference type="OMA" id="LCGWVDR"/>
    <dbReference type="OrthoDB" id="439710at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004815">
        <property type="term" value="F:aspartate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006422">
        <property type="term" value="P:aspartyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04321">
        <property type="entry name" value="ScAspRS_mt_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.30">
        <property type="entry name" value="GAD-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00044">
        <property type="entry name" value="Asp_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004524">
        <property type="entry name" value="Asp-tRNA-ligase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004115">
        <property type="entry name" value="GAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00459">
        <property type="entry name" value="aspS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001750">
        <property type="entry name" value="PRK00476.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594:SF5">
        <property type="entry name" value="ASPARTATE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594">
        <property type="entry name" value="ASPARTYL/LYSYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="7">
        <location>
            <begin position="226"/>
            <end position="664"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM26654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="681" mass="75906" checksum="254E44104A49C3DB" modified="2014-04-16" version="1">MTIAAVQLRNLRLRSSYIEISNLLRGRSAISPRQCYSPVQAPRQFHARAYLRQEEPSKRLPEFLEAYKRSVDFPPATHDFETFFAQAEPNTEVVLHGYLGNRADLSKKLSFVRLSDPTLQHSLQVVAFAKNDAFEKLKTVNVNSPVAVRGIVQKKKTKPSETENPPVQDLWELALEEIHPLNDFPKDLIMTPETVFPPEQRYLQLRSDAELREALRFRARAHNICKKELEEQCPPFVDIETPLLFKSTPEGAREFIVPTRREGLAYALPQSPQQYKQILMASGLPRYYQFARCFRDEDLRADRQPEFTQLDMEMSFATGDDVMRTVEGVIRRLWSSLMKDPAPEGPFRKVPYQKVMAKYGSDKPDTRYGMEIIRLDHVLPVDLVGKISDLANPIVEAFKVEGNDNNPAETHKFITQFLDSPAGAPFNNNPDGGPGVFVYNGKQPLCGLQPFGFEAAEQVEELLDPDHGDLIVLQARPRAPFSGGSTPIGDLRRALHAASVSVGFKPAPTGFDFLWVVDFPLFSPSSDSEPGQGGAAGFSSTHHPFTAPKTPADVDLLLTDPTQAVADHYDLVVNGVELGGGSRRIHDAAVQEFIFRDILKMPAERLTDFSHLLDALRSGCPPHAGLALGFDRLVAVMLGKESVRDVIAFPKTGKGGDDAMVGAPSPMTEEALKTYHLKLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W6PXJ9</accession>
    <name>W6PXJ9_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosomal protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PROQFM164_S01g000493</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the bacterial ribosomal protein bL36 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PXJ9"/>
    <dbReference type="STRING" id="1365484.W6PXJ9"/>
    <dbReference type="OMA" id="FSHMIRN"/>
    <dbReference type="OrthoDB" id="10265903at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00251">
        <property type="entry name" value="Ribosomal_bL36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000473">
        <property type="entry name" value="Ribosomal_bL36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035977">
        <property type="entry name" value="Ribosomal_bL36_sp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052010">
        <property type="entry name" value="Ribosomal_LSU_bL36"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01022">
        <property type="entry name" value="rpmJ_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18804">
        <property type="entry name" value="RIBOSOMAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18804:SF16">
        <property type="entry name" value="RIBOSOMAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00444">
        <property type="entry name" value="Ribosomal_L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57840">
        <property type="entry name" value="Ribosomal protein L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00828">
        <property type="entry name" value="RIBOSOMAL_L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDM26684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="107" mass="11816" checksum="ABF2FBCBD0F7EB9C" modified="2014-04-16" version="1">MFSLRAVFGASSGALRQFFPSVTTRTASLRPFSHMIRNSLTRLRGQAKSGNAVAVANGSAKQVEQVRGMKTRSSVKRLCDGCKPVHRKGRVYIICSKNPKHKQRQGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W6PYG6</accession>
    <name>W6PYG6_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Orotidine 5'-phosphate decarboxylase</fullName>
            <ecNumber evidence="3 10">4.1.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PROQFM164_S01g000818</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>orotidine 5'-phosphate + H(+) = UMP + CO2</text>
            <dbReference type="Rhea" id="RHEA:11596"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57538"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="EC" id="4.1.1.23"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the OMP decarboxylase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.23" evidence="3 10"/>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PYG6"/>
    <dbReference type="STRING" id="1365484.W6PYG6"/>
    <dbReference type="OMA" id="CLIKTHI"/>
    <dbReference type="OrthoDB" id="10263753at2759"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004590">
        <property type="term" value="F:orotidine-5'-phosphate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04725">
        <property type="entry name" value="OMP_decarboxylase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000114">
        <property type="entry name" value="Decarboxylase,orotidine phosphate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014732">
        <property type="entry name" value="OMPdecase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018089">
        <property type="entry name" value="OMPdecase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001754">
        <property type="entry name" value="OMPdeCOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01740">
        <property type="entry name" value="pyrF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32119">
        <property type="entry name" value="OROTIDINE 5'-PHOSPHATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32119:SF2">
        <property type="entry name" value="OROTIDINE 5'-PHOSPHATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00215">
        <property type="entry name" value="OMPdecase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00934">
        <property type="entry name" value="OMPdecase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00156">
        <property type="entry name" value="OMPDECASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="7 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 10" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orotidine 5'-phosphate decarboxylase" evidence="11">
        <location>
            <begin position="34"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="active site" description="For OMPdecase activity" evidence="8">
        <location>
            <position position="93"/>
        </location>
    </feature>
    <feature type="active site" description="For OMPdecase activity" evidence="8">
        <location>
            <position position="95"/>
        </location>
    </feature>
    <feature type="active site" description="For OMPdecase activity" evidence="8">
        <location>
            <position position="98"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR614732-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR614732-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDM27009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="259" mass="28218" checksum="914279488EB6318A" modified="2014-04-16" version="1">MSSKSQLTYSVRAQSHPNPLARKLFQVAEEKKSNVTVSADVTTTKELLDLADRLGPYIAVIKTHIDILSDFSQATIDGLNALAQKHNFLIFEDRKFIDIGNTVQKQYHNGTLRHSRCLAQTAQATDFPYGSERGLLILAEMTSKGSLATGAYTSASVDIARKYPSFVLGFVSTRSLGEVESTEAPAQDEDFVVFTTGVNLSSKGDKLGQQYQTPQSAIGRGADFIISGRGIYAAADPVEAVKQYQQQGWEAYLARVGAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2024-10-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>W6PYN4</accession>
    <name>W6PYN4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S01g000883</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PYN4"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM27074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="60" mass="6790" checksum="9D44A5D5DE442075" modified="2014-04-16" version="1">MLVTAKSTPESENVLCGLQTSINDDSPISYILRFVHIAMPEIQQGELSQAFFLTPFQLRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W6PYV9</accession>
    <name>W6PYV9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g000953</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PYV9"/>
    <dbReference type="STRING" id="1365484.W6PYV9"/>
    <dbReference type="OMA" id="CSGNECK"/>
    <dbReference type="OrthoDB" id="4356068at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004879265" evidence="1">
        <location>
            <begin position="19"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM27144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="55" mass="5653" checksum="C24A7CC63177A720" modified="2014-04-16" version="1">MKLFIVLFALAAYAMAEAGPNLEARAGCSQKGQYCNDGTFLCCPGQGSCSGGVCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W6PZ27</accession>
    <name>W6PZ27_PENRF</name>
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        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S01g003340</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PZ27"/>
    <dbReference type="STRING" id="1365484.W6PZ27"/>
    <dbReference type="OrthoDB" id="5598852at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM29528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="117" mass="12703" checksum="557F64C179F362EF" modified="2014-04-16" version="1">MNIHVNPSTGGIASIVDWRDATVGPFGLSFWGLETLLGTFGADGWHFHARHLELRRVLWETLYATAGIVTESQKRAVTVGRVVGIFQAYGLRKGVPVEAGDPSLSVLEEVLSVPECN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2024-10-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>W6PZB9</accession>
    <name>W6PZB9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S01g003420</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PZB9"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM29608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="72" mass="8438" checksum="71576A3F55C7F2C8" modified="2014-04-16" version="1">MLCKFYTLLELPVRAMLTLNEALSRVRVRLEYAPLAWRLETVFRFGELSTFHPPNPPRAFFNRKKMEAQGPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>W6PZM2</accession>
    <name>W6PZM2_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">mitogen-activated protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PROQFM164_S01g003307</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:17990"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:46609"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.24" evidence="2"/>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PZM2"/>
    <dbReference type="STRING" id="1365484.W6PZM2"/>
    <dbReference type="OMA" id="FIGAHPF"/>
    <dbReference type="OrthoDB" id="266718at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004707">
        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004709">
        <property type="term" value="F:MAP kinase kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd09534">
        <property type="entry name" value="SAM_Ste11_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.50:FF:000075">
        <property type="entry name" value="Serine/threonine-protein kinase STE11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000334">
        <property type="entry name" value="Serine/threonine-protein kinase STE11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000214">
        <property type="entry name" value="Serine/threonine-protein kinase STE11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000387">
        <property type="entry name" value="Serine/threonine-protein kinase STE11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050538">
        <property type="entry name" value="MAP_kinase_kinase_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029458">
        <property type="entry name" value="Ras-bd_By2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016">
        <property type="entry name" value="MAP KINASE KINASE KINASE SSK2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016:SF56">
        <property type="entry name" value="MAPKK KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14847">
        <property type="entry name" value="Ras_bdg_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00536">
        <property type="entry name" value="SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01304">
        <property type="entry name" value="Ras_bdg_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM" evidence="12">
        <location>
            <begin position="63"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="612"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="174"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="347"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="523"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="8"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="187"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="349"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="393"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="523"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="548"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="641"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDM29495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="892" mass="98608" checksum="0E742BD6E1B5CF1D" modified="2014-04-16" version="1">MLAPKQYSAPTGVSASQSSTAYHTNSSQRPATATRAQDGVGFVSPTRSELSEGLDELASVRAWDERRVVSWLHSIKCGQYESIFRANNFNGDNLLECDQKILQEMGIKKVGDRVRIFIAIKQLRNKSGATSRQKNMNTLAALEATALSNSSRYTHSRLPYRRTSQLADDAYLNSKSLSQPASPPAGDAERGTWRKDYLNHPSSGGSSSGRNPPTPNEGRPSSHPRNPSLDGLTMGPLPSNSPVIRVIHTGGQTKVLDIRNCRTPDEVILCVLKKLQLPEHQYRNYCFYVLDGLDPDLSNCRKLTESELMEICDGYNKSERGRLILRKIHAGEPDEDELRRASQLAYDESQATHQHALSNSNQRQKHKIQQLTGESWHNIKQPLSPLGPRHRPSNSSVDESQGPNSERNPVAKLRSFFGQRPPSEMIIHELQSFFPSHDRENIEKTMRRSQRLSRAASRMSVMSNYSVASSMKDAPPLPPLPHLPPIPSIADAWLHGPGVAQAVRIPRPISVSKFNLPQSSYRDSIASSSLQPLQEESPTEPNRKSYVSFESGSDDANQSRQSRQSFESLSVVATDGGSFNDRMSMIVAEDGEEEDDGLVDFLAGNNFAPKNWMKGSLIGEGSFGSVYLALHAITGELMAVKQVEIPSATKGTEFDQRKNLMVNALKHEIELLQGMSHPNIVQYLGTVADDQYLNIFLEYVPGGSIATMLKQYNTFQEPLVKNFVRQILAGLSYLHGRDIIHRDIKGANILVDNKGGVKISDFGISKRVEASHLLGARASGGAGANIHRTSLQGSVYWMAPEVVRQTAHTKKADIWSLGCLVVEMFIGAHPFPDCSQLQAIFAIGSNKARPPAPDNVSQEAVDFLDMTFHLDYEQRPTADELLRCAFLSTPIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W6PZS6</accession>
    <name>W6PZS6_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Beta-lactamase/transpeptidase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S01g003566</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PZS6"/>
    <dbReference type="STRING" id="1365484.W6PZS6"/>
    <dbReference type="OMA" id="WEIYRYV"/>
    <dbReference type="OrthoDB" id="10250282at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058664">
        <property type="entry name" value="ARB_00930-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051478">
        <property type="entry name" value="Beta-lactamase-like_AB/R"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22935:SF97">
        <property type="entry name" value="BETA-LACTAMASE-RELATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22935">
        <property type="entry name" value="PENICILLIN-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26335">
        <property type="entry name" value="ARB_00930_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004881688" evidence="1">
        <location>
            <begin position="20"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-lactamase-related" evidence="2">
        <location>
            <begin position="103"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-lactamase-like ARB-00930-like C-terminal" evidence="3">
        <location>
            <begin position="454"/>
            <end position="600"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF26335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM29753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="601" mass="64880" checksum="54B75C91EAA9A956" modified="2014-04-16" version="1">MRPNYVLTGLLCLPAAAFANLLGPSYPPPRDLSSNHSRVAASWKNLTSQLNTVLADNQANKSSGVFALKNLTFSAGLFSTLDPKAKDLQLHHTASEVANSPVGVNKVDGNSIYKVASVSKLFTVLAGLIELKPRDWDRPLTDIFPFLAERVRKQHDKFRLVYDVQWDKVTLKSLAGQMSGIPHGATEEFLQTFLLYKYLEHSHNPALTDPNFYGLPPLNGSDISLWPSCLGEQTQGCNPVSWDVAYAPRPPVYLPWTSPEYANGGYIFLGLAISNLTGKTMDEWYSESIFEPLGLKSTYSSTPGNSTRPHSVTSEALDEQFIPDGGATTPSGGLFSTINDLSKLGVALLNSTLLPSEKTREWMKPITHTSSLRYSVGSPWEIHRYVHAGSGVVTDLYTKLGDSGYYGGIVVVIPDFDAGFTLLSASTQSSRSSEALLAIDLIVDAILPALMEQAAAEAVQKFAGTYKAEDLNSSLTLAVVPPTQPAPGLNITSWISNGTDITALVSTLLGGVGSRLVPSIISEQASGEIAFRGYTATQGRNPGVGSSSSLFSSFYDLNDWTMLDQLTWGGIATSLFVFDVEQNGTVKSVTPGAYRVKMTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q072</accession>
    <name>W6Q072_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glycogen [starch] synthase</fullName>
            <ecNumber evidence="8">2.4.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PROQFM164_S01g003497</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Glycogen synthase participates in the glycogen biosynthetic process along with glycogenin and glycogen branching enzyme. Extends the primer composed of a few glucose units formed by glycogenin by adding new glucose units to it. In this context, glycogen synthase transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan.</text>
    </comment>
    <comment type="function">
        <text evidence="8">Transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>[(1-&gt;4)-alpha-D-glucosyl](n) + UDP-alpha-D-glucose = [(1-&gt;4)-alpha-D-glucosyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18549"/>
            <dbReference type="Rhea" id="RHEA-COMP:9584"/>
            <dbReference type="Rhea" id="RHEA-COMP:9587"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15444"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.4.1.11"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:18550"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Glycan biosynthesis; glycogen biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glycosyltransferase 3 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.11" evidence="8"/>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q072"/>
    <dbReference type="STRING" id="1365484.W6Q072"/>
    <dbReference type="OMA" id="RDVRNHI"/>
    <dbReference type="OrthoDB" id="6335297at2759"/>
    <dbReference type="UniPathway" id="UPA00164"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004373">
        <property type="term" value="F:alpha-1,4-glucan glucosyltransferase (UDP-glucose donor) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03793">
        <property type="entry name" value="GT3_GSY2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000014">
        <property type="entry name" value="Glycogen [starch] synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000045">
        <property type="entry name" value="Glycogen [starch] synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008631">
        <property type="entry name" value="Glycogen_synth"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10176:SF3">
        <property type="entry name" value="GLYCOGEN [STARCH] SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10176">
        <property type="entry name" value="GLYCOGEN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05693">
        <property type="entry name" value="Glycogen_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0320">Glycogen biosynthesis</keyword>
    <keyword evidence="3 8" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="672"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="693"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="707"/>
            <end position="716"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00043883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDM29685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="716" mass="81546" checksum="3E985C5C49CE083E" modified="2014-04-16" version="1">MEENGEPIKRDVRNHMLFEVATEVANRVGGIYSVLKSKAPVTTAEYGERYTMIGPLNRASAAVEVEELSPSNPAMRDTIQSMKERGIDIVYGRWLIEGAPRVLLIDTGTGYRWLDEWKGDLWNTSAIPSPAGDNETNEAIVFGYLVAWFLGEYIAHDRRRAVIAHFHEWLAGVALPLTKKRHMDLTTVFTTHATLLGRYLCAGSVDFYNNLQYFDVDAEAGKRGIYHRYCIERAATHACDVFTTVSHITAFESEHLLKRKPDGVLPNGLNVKKFSAMHEFQNLHSQAKEKINDFVRGHFYGHNDFDLDNTLYLFTAGRYEYRNKGVDMFIEGLARLNHRLKAAGSTMTVVAFIIMPAQTSSLTVEALKGQAVVKSLRDTVENIEKGIGKRMYERCLSWKEGDNMPDEKDLITSQDRVMLRRRLFGMKRTGLPPIVTHNMVNDHEDPILNQLRRVQLFNHSSDRVKVIFHPEFLNSANPVLPLDYDDFVRGTHLGVFPSYYEPWGYTPAECTVMGVPSITTNLSGFGCYMEELIENSSDYGIYIVDRRSKGVDDSVNQLTEFMFNFTEKSRRQRINQRNRTERLSDLLDWKRMGLEYVKARQLALRRAYPSSFEGQEDYFDIIGGTEQKLSRPLSVPGSPRDRSGMMTPGDFASLQEGHEGLSTEDYIAWKLPEEEEPEEHFPLTLRTRKMAERSSSPLDSISVNGREGSDAGYRTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q0H8</accession>
    <name>W6Q0H8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g003278</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q0H8"/>
    <dbReference type="STRING" id="1365484.W6Q0H8"/>
    <dbReference type="OMA" id="QVKSYCT"/>
    <dbReference type="OrthoDB" id="5530243at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005655">
        <property type="term" value="C:nucleolar ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000172">
        <property type="term" value="C:ribonuclease MRP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000171">
        <property type="term" value="F:ribonuclease MRP activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004526">
        <property type="term" value="F:ribonuclease P activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034965">
        <property type="term" value="P:intronic box C/D snoRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000294">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, RNase MRP-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020347">
        <property type="entry name" value="Pop8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049128">
        <property type="entry name" value="Pop8-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28173">
        <property type="entry name" value="RIBONUCLEASES P/MRP PROTEIN SUBUNIT POP8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28173:SF1">
        <property type="entry name" value="RIBONUCLEASES P_MRP PROTEIN SUBUNIT POP8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20976">
        <property type="entry name" value="Pop8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribonucleases P/MRP subunit Pop8-like" evidence="1">
        <location>
            <begin position="41"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM29466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="161" mass="17077" checksum="731EAE2C78A14BE8" modified="2014-04-16" version="1">MTEDTHGDMEIDTNVAVTEAAKRKAPEPKPKIIHFTSRNPPWTYLKLKLVSQPGSAPQPLDALSARTYLSSALSQFLGLTGTAIPIDILKIEDGSPSTTKYHIMWIRVPREDASAVVSAVSSWIGGGNNSASSGDVAWRVCAKGNFLGALVAGSGADLFVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q0N2</accession>
    <name>W6Q0N2_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Splicing factor PWI</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PROQFM164_S01g001560</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q0N2"/>
    <dbReference type="STRING" id="1365484.W6Q0N2"/>
    <dbReference type="OMA" id="DGCVNKK"/>
    <dbReference type="OrthoDB" id="6275295at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12446">
        <property type="entry name" value="RRM_RBM25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1390.10">
        <property type="entry name" value="PWI domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002483">
        <property type="entry name" value="PWI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036483">
        <property type="entry name" value="PWI_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052768">
        <property type="entry name" value="RBM25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034268">
        <property type="entry name" value="RBM25_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18806">
        <property type="entry name" value="RBM25 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18806:SF4">
        <property type="entry name" value="RNA-BINDING PROTEIN 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01480">
        <property type="entry name" value="PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00311">
        <property type="entry name" value="PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101233">
        <property type="entry name" value="PWI domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51025">
        <property type="entry name" value="PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="135"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="PWI" evidence="5">
        <location>
            <begin position="658"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="79"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="346"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="417"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="528"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="91"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="346"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="367"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="435"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="528"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDM27749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="751" mass="83772" checksum="57BD740E1F7B0238" modified="2014-04-16" version="1">MYNPYQAPGLYGRAPDYGAYGAPPGMAPPPGMAAPGTAAPLGMQQANIQPGRPGSFPPNFQPPMNMPNINFSAPVIRLGTSGPNKPAAQENGRERGPDAPGRRGGLGSMGMDTQRHHGRETMMQLQPPTRDEVVRTIFIGGITEGAGGDDGIERILRSTGILRRWIRATDADDKPCRFGFAEYDDPESLEIAVETLKDVEVPVKIQVPLAEGDEEQKVEKSKLLVVVDEGTLTYLEQFESSRAEQDPEERQARFTAARNNLNKVLTSLFHPTAPLTKEEISALDREGDTEMKDAEPAKDGEVVTIPITIEDELADIPPEMRANVAKEISAFRERSTRRDIERMKREEEIESMERARNSGSRINRLVSPPASAPSGPAAGINGIPLGPRDRNVMNAPSGPRAFGVQIPKDYQKGVAFVNADALNGDDNSDASDEEIERRRQDRLKAEQEKEFSDLERRWLGRERSRTAALEREKKREDEEDGKLQAAHDEMEARLNAWNDDVEDTRKAVDYYADRGTWLRTRAAFRSREAHVDDADRAAEDRERVQSAKQQEQARGMADDFLARQAKELETRPQEAPREPQRFKLSLGAAAQKAQAATSRRAVADVEGLLEDEEEPETTTRRPLIPIKFDSAAEAAGLTDEERAQAARQLAAEIPAEKEGLWNWAIKWEFVDDAIITDQLKPFVEKKIVEYLGVQEQMLVDVVEEHVRKHGSPQELVEQLAEALDEEAEVLVRKLWRMIIFCSESEKRGLSL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2018-06-20" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q0S4</accession>
    <name>IFGH_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fumigaclavine B O-acetyltransferase ifgI</fullName>
            <ecNumber evidence="1">2.3.1.205</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Isofumigaclavine biosynthesis cluster B protein I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ifgI</name>
        <name type="ORF">PROQFM164_S02g000302</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>FM164</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2017" name="Appl. Microbiol. Biotechnol." volume="101" first="6111" last="6121">
            <title>Silencing of a second dimethylallyltryptophan synthase of Penicillium roqueforti reveals a novel clavine alkaloid gene cluster.</title>
            <authorList>
                <person name="Fernandez-Bodega A."/>
                <person name="Alvarez-Alvarez R."/>
                <person name="Liras P."/>
                <person name="Martin J.F."/>
            </authorList>
            <dbReference type="PubMed" id="28620689"/>
            <dbReference type="DOI" id="10.1007/s00253-017-8366-6"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>PATHWAY</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2017" name="Org. Biomol. Chem." volume="15" first="8059" last="8071">
            <title>A bifunctional old yellow enzyme from Penicillium roqueforti is involved in ergot alkaloid biosynthesis.</title>
            <authorList>
                <person name="Gerhards N."/>
                <person name="Li S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28902217"/>
            <dbReference type="DOI" id="10.1039/c7ob02095c"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <comment type="function">
        <text evidence="2 3">Fumigaclavine B O-acetyltransferase; part of the gene cluster that mediates the biosynthesis of isofumigaclavines, fungal ergot alkaloids (PubMed:28620689). The tryptophan dimethylallyltransferase ifgA catalyzes the first step of ergot alkaloid biosynthesis by condensing dimethylallyl diphosphate (DMAP) and tryptophan to form 4-dimethylallyl-L-tryptophan (PubMed:28620689). The second step is catalyzed by the methyltransferase ifgB that methylates 4-dimethylallyl-L-tryptophan in the presence of S-adenosyl-L-methionine, resulting in the formation of N-methyl-dimethylallyl-L-tryptophan (PubMed:28620689). The catalase ifgD and the FAD-dependent oxidoreductase ifgC then transform N-methyl-dimethylallyl-L-tryptophan to chanoclavine-I which is further oxidized by ifgE in the presence of NAD(+), resulting in the formation of chanoclavine-I aldehyde (PubMed:28902217). The chanoclavine-I aldehyde reductases ifgG and/or fgaOx3 reduce chanoclavine-I aldehyde to dihydrochanoclavine-I aldehyde that spontaneously dehydrates to form 6,8-dimethyl-6,7-didehydroergoline (PubMed:28620689, PubMed:28902217). The festuclavine dehydrogenases ifgF1 and/or ifgF2 then catalyze the reduction of 6,8-dimethyl-6,7-didehydroergoline to form festuclavine (PubMed:28620689). Hydrolysis of festuclavine by a yet undetermined cytochrome P450 monooxygenase (called ifgH) then leads to the formation of isofumigaclavine B which is in turn acetylated by ifgI to isofumigaclavine A (PubMed:28620689). Penicillium roqueforti has interestingly at least two sets of genes for the consumption of chanoclavine-I aldehyde on three different loci, the OYEs ifgG/fgaOx3 and the festuclavine synthase homologs ifgF1/ifgF2 (PubMed:28620689, PubMed:28902217). The reason for the duplication of these genes is unclear, probably to ensure the conversion of chanoclavine-I aldehyde by differential gene expression under various environmental conditions (PubMed:28902217).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>fumigaclavine B + acetyl-CoA = fumigaclavine A + CoA</text>
            <dbReference type="Rhea" id="RHEA:34267"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:67145"/>
            <dbReference type="ChEBI" id="CHEBI:67146"/>
            <dbReference type="EC" id="2.3.1.205"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Alkaloid biosynthesis; ergot alkaloid biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the fumigaclavine B O-acetyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.205" evidence="1"/>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q0S4"/>
    <dbReference type="SMR" id="W6Q0S4"/>
    <dbReference type="STRING" id="1365484.W6Q0S4"/>
    <dbReference type="OMA" id="ILPRMYF"/>
    <dbReference type="OrthoDB" id="1862401at2759"/>
    <dbReference type="UniPathway" id="UPA00327"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035835">
        <property type="term" value="P:indole alkaloid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050317">
        <property type="entry name" value="Plant_Fungal_Acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054710">
        <property type="entry name" value="Tri101-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31642:SF270">
        <property type="entry name" value="O-ACYLTRANSFERASE AUSQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31642">
        <property type="entry name" value="TRICHOTHECENE 3-O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22664">
        <property type="entry name" value="TRI-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0012">Acyltransferase</keyword>
    <keyword id="KW-0017">Alkaloid metabolism</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000444547" description="Fumigaclavine B O-acetyltransferase ifgI">
        <location>
            <begin position="1"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="Q4WZ64"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="28620689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="28902217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="4">
        <source>
            <dbReference type="PubMed" id="28620689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <evidence type="ECO:0000305" key="6">
        <source>
            <dbReference type="PubMed" id="28620689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM30153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="484" mass="53739" checksum="0AFC7D093301C8B3" modified="2014-04-16" version="1">MSTSFDHSVILSPLDHIAPQAYVSYLLSFQTANSTHCLSLLEAGITRLTKVLPLLLGHIVVNPELDGKYNIQSVQIPCTKEDRTILVHKHHPFPMESALGGVQSGMSMLETSDSKQHLCPLPPLIPSTERQPVIRFQANIFTDAIVLAMTFSHIVFDGTGAAKILALLGRCCRDPSVTPLPLIIDEQDRAQSAIFAGLADTSPAQDHTAELGPAPAIHPVPLDAASLRTCRFEFNSERILQLKYQCSQVLKNACMFQPNSASIPVADLPPFLSSNDVLTSALADAIQRVKSQSKTYDCLDLCMAVNMRGRIELSAAREFLGNMACNLRLKTPGPEYTGPEQCLSCRKTHDCPIQTDQLRFLTDLACKVRNKVRNMDRKYFQSCMTYIANQKDWSQTGMIFTDLAFSSWRHLDIYGLDFGDSFGIVHNFDLSFGLIEGDVIFLPKRLTCDQKEAGWDVHITLPAKDLEALVKDDLIRWLMGRDGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2024-10-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q167</accession>
    <name>W6Q167_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S01g003528</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q167"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM29716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="56" mass="6309" checksum="30B01657BCF30907" modified="2014-04-16" version="1">MRYGSHLRLAGYVSAAGFFLTTNNTSSCHQKHIHDRNPIRVSEQISHGTWLGSRIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q1D6</accession>
    <name>W6Q1D6_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Branched-chain-amino-acid aminotransferase</fullName>
            <ecNumber evidence="11">2.6.1.42</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">BAT1</name>
        <name evidence="12" type="ORF">PROQFM164_S01g001845</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-isoleucine + 2-oxoglutarate = (S)-3-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24801"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:35146"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:18321"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:17865"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-valine + 2-oxoglutarate = 3-methyl-2-oxobutanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24813"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.42" evidence="11"/>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q1D6"/>
    <dbReference type="STRING" id="1365484.W6Q1D6"/>
    <dbReference type="OMA" id="LTEVFAC"/>
    <dbReference type="OrthoDB" id="1732691at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052656">
        <property type="term" value="F:L-isoleucine-2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052654">
        <property type="term" value="F:L-leucine-2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052655">
        <property type="term" value="F:L-valine-2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:L-leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01557">
        <property type="entry name" value="BCAT_beta_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.10.10:FF:000004">
        <property type="entry name" value="Branched-chain-amino-acid aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.10:FF:000005">
        <property type="entry name" value="Branched-chain-amino-acid aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="entry name" value="D-amino Acid Aminotransferase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018300">
        <property type="entry name" value="Aminotrans_IV_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005786">
        <property type="entry name" value="B_amino_transII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033939">
        <property type="entry name" value="BCAT_family"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01123">
        <property type="entry name" value="ilvE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009897">
        <property type="entry name" value="PRK13357.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11825:SF44">
        <property type="entry name" value="BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11825">
        <property type="entry name" value="SUBGROUP IIII AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006468">
        <property type="entry name" value="BCAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="D-aminoacid aminotransferase-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00770">
        <property type="entry name" value="AA_TRANSFER_CLASS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3 11 12" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="7 11" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="6 10" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11 12" id="KW-0808">Transferase</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="8">
        <location>
            <position position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR006468-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDM28034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="398" mass="43878" checksum="4CFD6C562E89418D" modified="2014-04-16" version="1">MPRVLSSQNITASRTWQRTFSASMAAASQLPGLDPSKLTITKTTTPKELKESKDLVFGKYFTDHMLSVEWTATDGWHAPRIIPYQNLSLDPATCVFHYAFECFEGMKAYKDSTGGIRLFRPNKNMERLNKSSARIALPTIDGDALTKIIGELVKLDSRFIPDARGYSLYLRPTMIGTQKTLGVGPPGSALLYVIASPVGPYYPTGFKAISLEATDYAVRAWPGGVGDKKLGANYAPCILPQLEAASRGFQQNLWLFGEEEYVTEVGTMNLFIALKNKETGEKELITAPLDGTILEGVTRDSVLTLARERLGPKGWKICERKIRMSEVAEAAEEGRMIEVFGSGTAAIVSPVRNISYRGKTVDCGLKADEEAGEIALQMKNWMEGIQYGDEKHEWSVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q1E8</accession>
    <name>W6Q1E8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Amino acid/polyamine transporter I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PROQFM164_S02g000512</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q1E8"/>
    <dbReference type="STRING" id="1365484.W6Q1E8"/>
    <dbReference type="OMA" id="CSAMGCL"/>
    <dbReference type="OrthoDB" id="3257095at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF25">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="40"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="76"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="121"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="192"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="274"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="327"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="377"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="407"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="461"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="496"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM30363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="530" mass="57225" checksum="4C065E0D13560509" modified="2014-04-16" version="1">MVAYELKSNTSVTSRGEGQVDRDNAHLQRMGKRPVLKRKFGILSILGFSCTILGTWEGLLGTFTGPLTNGGSGGAIYAYIFGWVGCFANFMVLSELASMAPTAGGQYHWAAMLAPGSHQKFLSFITGWFAVLGWQSAFAACAFLTGKMIQGAAILGNNLYNALPWEGTLIVWASLSLALVVNLLPGNLLPRIEVIILVVHILGFFGIIIPLIYMADHNTKEQVFLSFQNGGGFATQGLSWFVGMTSCAFAFAGGDAAVHMSEEVANASTVIPNALMISVGINGCLGFGMIIVMMFCTDSDLGGKLGSATGYNFMGIFMEATNSVPGSLAMCAIVITIYVCSLMGLLAAASRQLWSFSRDRGVPGWRWWSQVSSTKQLPIFAILLTVTVAVLLSLINIGSDTAMEDIVSMAVSGIYLSYLMVSVLLFYRRIRGDISRYNDNEDDIVNVPGAKLVWGPFHCPGIIGTLINGYAIIYISIVIFFSFWPSTMDPTVETMNWSILAIGGSVFLAIIYYVVRARHVYKGPIVEVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q244</accession>
    <name>W6Q244_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S02g000215</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q244"/>
    <dbReference type="STRING" id="1365484.W6Q244"/>
    <dbReference type="OMA" id="MRHPWGV"/>
    <dbReference type="OrthoDB" id="4363600at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM30066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="363" mass="42203" checksum="4C7ED3B2F2949766" modified="2014-04-16" version="1">MQSPQLSQLADEMTYIIPSKLMRPKSNPFTNDSQLKDISPTIFRPATPNEVCFASHLNRYMHHPWGVVDYYIYLLHIESGRNKLRRKKECYLLETTGFTQVTLHDEPVLNNLPTHTNPTVIFVSLPVPDMQNEFSNARLVLGFDLQSDRLQGYFFEPEAPIENYEDLWKVWNQGEGELVIDVPVDRFLAIVRYTMEHQIEILEIGVLHHYGLITREFQAGLDMVVTLQFLQFVDDFAELLAEEPDELRELYTPFQDELRELLATGSRDTWFAVRDGLNMEQYRQKQLKKVVASGLFHGQNMFVLRDESEGTENDEPRPVKIVPGHSHQWSRLKLRIQILVSATLIICLCSIFERDRVLCVGMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q264</accession>
    <name>W6Q264_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">PROQFM164_S01g002080</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q264"/>
    <dbReference type="STRING" id="1365484.W6Q264"/>
    <dbReference type="OrthoDB" id="4367377at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="2">
        <location>
            <begin position="99"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM28269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="143" mass="15186" checksum="BD384C69FFF85D67" modified="2014-04-16" version="1">MSPEARFAVVASTGAFDFMPAFEDAILCIVPSALFLVVSLQSLFWLARQPRKVAKSHRPIVEVAPDEKGDTLVAISGANFGWVPGKPDILNDITVGIRRFTFVVGPVGSGKSTLMRAILGEVPLQAGSIHADPGNIAFVGQEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q393</accession>
    <name>W6Q393_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">26S proteasome regulatory subunit RPN1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">rpn-1</name>
        <name evidence="9" type="ORF">PROQFM164_S02g000895</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 5">Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the proteasome subunit S2 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q393"/>
    <dbReference type="STRING" id="1365484.W6Q393"/>
    <dbReference type="OMA" id="GTCNGDI"/>
    <dbReference type="OrthoDB" id="10252509at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034515">
        <property type="term" value="C:proteasome storage granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042176">
        <property type="term" value="P:regulation of protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000026">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016643">
        <property type="entry name" value="26S_Psome_Rpn1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002015">
        <property type="entry name" value="Proteasome/cyclosome_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041433">
        <property type="entry name" value="RPN1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040892">
        <property type="entry name" value="RPN1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10943">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10943:SF1">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01851">
        <property type="entry name" value="PC_rep"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18051">
        <property type="entry name" value="RPN1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17781">
        <property type="entry name" value="RPN1_RPN2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015965">
        <property type="entry name" value="26S_Psome_Rpn1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5 9" id="KW-0647">Proteasome</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="RPN1 N-terminal" evidence="7">
        <location>
            <begin position="61"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="26S proteasome non-ATPase regulatory subunit RPN1 C-terminal" evidence="8">
        <location>
            <begin position="846"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00057191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR015965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM30745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="903" mass="100149" checksum="DABE0F111F1E0A14" modified="2014-04-16" version="1">MANEGERPTSADKGKGKVDDVRELSGKNTENGEKPADEKKKDEASKDEELSEEDQQLKSELEMLVERLKEPDTSLYGPALDAIKNFIKTSTSSMTAVPKPLKFLRPHYDDLTALYEKWAPGPVQNSLADMLSVLGMTCGDEEKLDTIKYRLLAKSEDLGSWGHEYVRHLALELGQEYQNRLNADQDTQDLVDLALSLVPYFLSHNAEADAVDLMSELEIIEDIPQFVDENTYARVCLYMVSMVNLLTYPEDQQFLRTAHGIYVRYNKLSQAIVLAIRLNDIDLIKSDIHATTDKSLKKQMAFLVARQQIWLDLPAEDEEGEALADCLNNTSIPKHFKSLAKELNILDPKMPEDIYKTHLESSRGAGLTNLDSARHNLASAFVNSFVNAGFGNDKMMLVEGDKGPWVWKTKDDGMLSTTASLGMLLHRDVEDGLDKIDKFTYAQEDQVKAGALLAIGILNSGVRLDSDPALALLSDPDNLEAKSVPMRVASIMGLGLAYAGSNKEELLEVLLPIVEDASLDMQLSAMAAVSLGLIFVGSSNHQVSEAIATTLMDEERQKQLKDKWTRFMALGLALLYFGRQEEVDVILDILKAVDHPMAKPTSVLASVCAWAGTGTVLKLQELLHICNDIIEEKEENKGDELVQSYAVLGLSLIAMGEDVGQDMILRQFGHLMHYGSSNIRRAVPLAMGLISPSNPQMKVYDTLSRYSHDNDNDVAINAIFAMGLCGAGTNNARIAQLLRQLASYYHRDQNSLFMVRIAQGLLHMGKGTMTLNPFHTDRQVLSRVSAAGLLTVLVSLIDAKQFILAEHHYLLYFLITAMFPRFLITLDEDLQPLTVNVRVGQAVDVVGQAGRPKTITGWQTQSTPVLLAHGERAELEDEQYIPLSSTLEGLVILRKNPDYENPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q3L5</accession>
    <name>W6Q3L5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S02g000705</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q3L5"/>
    <dbReference type="STRING" id="1365484.W6Q3L5"/>
    <dbReference type="OMA" id="HSRCETP"/>
    <dbReference type="OrthoDB" id="2163387at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40468:SF1">
        <property type="entry name" value="TOPOISOMERASE I DAMAGE AFFECTED PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40468">
        <property type="entry name" value="YALI0A15257P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="295"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM30556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="353" mass="38826" checksum="EC3F41D332242C34" modified="2014-04-16" version="1">MSPSQPGSAEKTIRKIDIAQVSLSLQDRLGLAKLKYQHGRLHGLNPHQHDGRPVLETDKPSDSSSEFSRSRCETPFTSPPLQASTYSKELPRSARNKHAATFNSRVMQPMLTASRKRLRSDSDSERPAKVHRVSWKSSHRLPESSPGMNRHRPSRRTQLPFMSEAIIPEVSSPVYPRPSEEIDPDLPVHSFQHISSVIGSSPPRTPPPKHMRLSRNNQPQNHEDGADLLLYLANSPTPARVARGNGNLAFPPSTPPSQHALLPGMTPTLGAGMFANISTPNQQFNFADFVNVTPSPAQPTWSSRTPGNPARTPLTSSRKRLNFDALVPPSNSSPRLRSKETGLALQLGGELHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q3Z4</accession>
    <name>W6Q3Z4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Oxoglutarate/iron-dependent dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PROQFM164_S02g000836</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q3Z4"/>
    <dbReference type="STRING" id="1365484.W6Q3Z4"/>
    <dbReference type="OMA" id="FTTRHDP"/>
    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044283">
        <property type="term" value="P:small molecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.330:FF:000051">
        <property type="entry name" value="Clavaminate synthase-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10209">
        <property type="entry name" value="OXIDOREDUCTASE, 2OG-FE II OXYGENASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10209:SF886">
        <property type="entry name" value="UPF0676 PROTEIN C1494.01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="6">
        <location>
            <begin position="179"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM30686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="360" mass="39456" checksum="7FB5976878C39D83" modified="2014-04-16" version="1">MADTTVPIELPVIDISNPHDPAVGKAMLDAATKYGFLYVNSKGTDFTVEDVDHAFGLSKKFFSSPSQEKETCKIQPNNRGWSGMHTETLDPEHQRTGDFKEAMNFGDFKDSKAQQLLPPSLEPHEAEINGFAELCNKTCTRILTLLALGLEIQEDFFTTRHDPSTGATGSILRYLYYPSIFSPTTAAYKHDKDVRAGAHSDYGSITLLFQRPGQPGLEILTPEDSWAPVPIVPGTAAEAEGYPFPPILVNIGDLLSYWTDGLLKSTVHRVVFPLAEQRSPNPQDRYTLVYFCHPVDETELVPVPSGIVAAHRERTGGVPADGRVGFGGGAGNLVPGKRPLTAHEHLMSRLEATYGFTKDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q4L1</accession>
    <name>W6Q4L1_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S02g001405</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q4L1"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM31255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="280" mass="31736" checksum="9979C81D6B3E2192" modified="2014-04-16" version="1">MPSRRSAETPQPSGFQAESQEPQVTTSFITEEPRGHSISRISLITTASDHSGMAPYPSSFQVEDPNGYSMTRMSLITTASDHSGMAPHLSGFQVEDAYEMRRMSEITTASDHSGMAPYPSGFQVEDPNGRSMARMSFITTASDHSYAAYASSDEGTPTGLVGNIRRLVGNIRRYFQSRRDNNHESSGRLGRARQHLGFAGRHTGRRFRRRLHDLREQRGERQRHERELRRLENLLANRPPRTSTVDWDFQPQTDWRILPSPWQRESDHEQGSTADPFGED</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q5D8</accession>
    <name>W6Q5D8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Carbohydrate-binding WSC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S02g002019</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q5D8"/>
    <dbReference type="STRING" id="1365484.W6Q5D8"/>
    <dbReference type="OMA" id="GNMCYCG"/>
    <dbReference type="OrthoDB" id="2019572at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051589">
        <property type="entry name" value="Sialate-O-sulfotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002889">
        <property type="entry name" value="WSC_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45964">
        <property type="entry name" value="WSCD FAMILY MEMBER CG9164"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45964:SF5">
        <property type="entry name" value="WSCD FAMILY MEMBER CG9164"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01822">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00321">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51212">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004879372" evidence="2">
        <location>
            <begin position="21"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="3">
        <location>
            <begin position="21"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM31868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="205" mass="20415" checksum="7F8563F464D16E6F" modified="2014-04-16" version="1">MHSNYILSALALALPVYSLSSTASMGCYSAIESFKNQGPYTYQSPGHCQAQCAEDNYKVAALSRGNMCYCGNEMPPDSAKIADSKCDVPCAGWPAGSCGGADTFNLIQAAENLQPSASENASTTIAPTAATAAGGIIVAASTANPPTGIVTAVSTANSKSGNVLSKSAVFASATATPTPTNNAAGTVCAGSSLLGAVFVGMGLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q5Y0</accession>
    <name>W6Q5Y0_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 11">Chitin synthase</fullName>
            <ecNumber evidence="2 11">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">chsC</name>
        <name evidence="14" type="ORF">PROQFM164_S02g002254</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Polymerizes chitin, a structural polymer of the cell wall and septum, by transferring the sugar moiety of UDP-GlcNAc to the non-reducing end of the growing chitin polymer.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-D-glucosamine = [(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16637"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9595"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="EC" id="2.4.1.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cell membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the chitin synthase family. Class I subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="2 11"/>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q5Y0"/>
    <dbReference type="STRING" id="1365484.W6Q5Y0"/>
    <dbReference type="OMA" id="AWILHYV"/>
    <dbReference type="OrthoDB" id="26569at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04190">
        <property type="entry name" value="Chitin_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013616">
        <property type="entry name" value="Chitin_synth_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF9">
        <property type="entry name" value="CHITIN SYNTHASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01644">
        <property type="entry name" value="Chitin_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08407">
        <property type="entry name" value="Chitin_synth_1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 11" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="4 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="563"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="603"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="638"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="672"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="716"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="845"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="887"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin synthase N-terminal" evidence="13">
        <location>
            <begin position="176"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00046324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU366040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDM32103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="920" mass="104365" checksum="6B5035A71C70C947" modified="2014-04-16" version="1">MAYNRVDADPFGDEHTSPILHPSHLTGYSHRPPSPGQPLEPGYQLSDNPYTYAPQSHLVMPSSDRLAEQPTYSVEHVDSSYGHHPAYDAQRPYPGHEYSLDPEAHHDAYYTQPYEPTQTPHDDYDLGQYPEGGQTPFEADQPILQTGENPFGPDPYTEFHDEPRPTPSPAPLRRWKTVKEVQLFNGNLVLDCPIAPRLLSQIPHAEAPGRDEFTHMRYSAATCDPADFFEERFTLRQKLFAKPRNTELFIAVTMYNEDDFLFARTMSGVFKNIDHMCSRTSSKTWGKDSWKKIVVCIISDGRAKINPRTRAVLAALGVYQDGIAKQQVNGKDVTAHIYEYTTQVGLEVKGTQVHLKPRSGPPVQLIFCLKEKNQKKINSHRWFFQAFGRVLDPNICVLLDAGTKPGKDSIYHLWKAFDVEPMCGGACGEIKVMLSHGKKLLNPLVAGQNFEYKLSNILDKPLESSFGFITVLPGAFSAYRFVALQNDKNGQGPLERYFLGEKMHGANAGIFTANMYLAEDRILCFEIVSKRKCRWLLQYVKSSTGETDVPDQMAEFILQRRRWLNGSFFAAVYAITHFYQIFRSDHSFIRKFMLMIEFVYQTIAMIFAWFGIGNFFLVFHILTTYLGSDDLLGTAGKVLGIIFEWLYLATLVTCFVLALGNRPGGSNKFYMTMVYFWIVIMIYLAFAAVFVTVKSIQTEVESNTFTVSQLFTNKTFFSIIVSLGSTYVMWFLASFIFLDPWHMFTSFIQYILLTPTYINVLNIYAFCNTHDITWGTKGDDKAEKLPSAHLKPGGKVDVNIPQDDGDLNDQYDAELAKFSMKPPKEITVISEEEKQADYYKGFRSAVVLAWVFCNFALGAVVLSAAGLETFDDTSTTSSDDAQTERSMIYMEVVLWSVAGLSMFKFMGAMWYLVVRMFRGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q6G5</accession>
    <name>W6Q6G5_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="10">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PROQFM164_S02g001751</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="10"/>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q6G5"/>
    <dbReference type="STRING" id="1365484.W6Q6G5"/>
    <dbReference type="OMA" id="HLEWLVI"/>
    <dbReference type="OrthoDB" id="3370at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17956">
        <property type="entry name" value="DEADc_DDX51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="14">
        <location>
            <begin position="231"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="267"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="13">
        <location>
            <begin position="635"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="571"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="9">
        <location>
            <begin position="231"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="7"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="80"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="134"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="586"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="620"/>
            <end position="639"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CDM31601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="813" mass="88207" checksum="87B0BD57205C37D4" modified="2014-04-16" version="1">MAGKNSGLESSNNFDATPQSTQSHKRKRDAHGSQPATTPTPTKKHKKREGLPIAEVTDDGSIKKRKHLKDALQGSNSPETPRKDTTLSDRTKATVGNPRNGTSETAEKSKKSKRKSSGTDDTLKDAAASVTTGNEDEEVEAPEAEQPKSKNKHSGIMSKFERTKSVSSAKAKKFEPEAVVDETPTVEAVYAQGLEQLPQPENPPEPEQIPTYSSLPAWLANPLRKSAQDTKKFSELGIKPDLLKILEQQNYKQAFAVQSTVIPLLLQGEQNHPGDLCISAATGSGKTLSYVLPLVTALSPRPASRLRGLIVVPTRELVKQARESCELCASGSRLHIGSAVGNVAIKEEQKLLMRVDQVYNPALQQQQRDGLKGNDWMNLSLEDCVSEAIDSDASLPGYIQQSEPNVDILICTPGRLVDHIRYTKGFTLKHLEWLVIDEADRLLNESFQEWVDVVMNSLNSREAPETFGPGGKLLSELGLSIDAKPPRKVILSATMTRDISKLNSLRLANPKMIIIGSENAADEHDPSAIHADSHFALPPTLSEYIVQVGDGSLKPLYLLRLLLSHIEIGGGRAPSVSDSSDSDSSSSDDDTSSDDDTSSDDDTSSDRSSDDDTSSSGSDSDSESDSSDSSDSSDSESDAMELVPSPARKTVLIFTKSSESASRLARLISLLHPALAKRVGTIIKSNKSSASRKTLTAYRQGRISVIVATDRASRGLDLESLTHVINYDIPTSITTYVHRVGRTARAGRPGSAWTLVAHREGRWFANEIAASVDGRITRTSNIDRVQIKADALDSLKPKYAKALDKLEQEVKRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q6N6</accession>
    <name>W6Q6N6_PENRF</name>
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        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S02g000063</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM29914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q6N6"/>
    <dbReference type="STRING" id="1365484.W6Q6N6"/>
    <dbReference type="OMA" id="RGCENEI"/>
    <dbReference type="OrthoDB" id="4181570at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM29914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="105" mass="11964" checksum="739EB2B73CD852BC" modified="2014-04-16" version="1">MPYKSLLENAAAVAAAKVRSQITRTSHDRYPWLFVSPRSKEDVRPVVECLLEDKAKLQSISSKTSITFPEDPWRAVVDYYPVVWTKRAGKLEPPFPGKHLVITPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q7E9</accession>
    <name>W6Q7E9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S02g002809</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OMA" id="EQAQNWT"/>
    <dbReference type="OrthoDB" id="4290694at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM32658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="348" mass="38660" checksum="542E84D8AE031011" modified="2014-04-16" version="1">MALSGLHLARNWMQAGVGVLRGIAHSMYHDGNSSSGSSTYPLVGVPIDYPYGLTPAPLMDSAPAVDQASDVCWSFEQAQNWTITRASPTVTLSPLPISRYREIRPRPLHESASTLPPVQPGKEEQHSQYRKLGRRKHSKSHRQSDQGYLKKTARSAIRTASEVTDTTKKQVRVGRMSRAKPPKAPGGDSATQGPRRRSPDCSSNHPEDSPQASVGALQRALKAQVLQSLEVLREIAKEFRAFNLGLETIDDWVAEIKEVDETLIPVPSSTAVLQVHVPFEKLSFILTKCITASGRMRDFIVRDQALELLKYIQTYAEEYHLFKNLRVHLDIDSTAAILLFQTFPPPAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q7S9</accession>
    <name>W6Q7S9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S02g002601</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q7S9"/>
    <dbReference type="OrthoDB" id="4355239at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM32450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="196" mass="22386" checksum="6662AE3C08B647A9" modified="2014-04-16" version="1">MVSIRPAPIPVQFLYGPAKVALEAMIFLRIDSPVLLKWTPSENSSQDARMLLDACKALRNSRSRETYLDENISLEEGLRAFEGNVLHSLSYSTVLMLVLMTWHFDASSSEASWGLIAFLRQPYDNEVRRILQGRYSSIMPLMTWHFDASSSEASRGLIAFLRQPHDNEVRRILQGRYSSIMRETAPSNFDFLLVLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2024-10-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q999</accession>
    <name>W6Q999_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S02g002742</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q999"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM32591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="76" mass="8662" checksum="878C1C364B74C3EF" modified="2014-04-16" version="1">MFSWSQSLENNSSPYTQFYRQSSNSSRWLITRKNASGSHELTGSQEWVLWAGPPAAPNLYSKHPTHLENDAECSIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q9M2</accession>
    <name>W6Q9M2_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S02g001039</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q9M2"/>
    <dbReference type="STRING" id="1365484.W6Q9M2"/>
    <dbReference type="OMA" id="NEPRDQE"/>
    <dbReference type="OrthoDB" id="3068835at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053221">
        <property type="entry name" value="Burnettramic_acid_biosynth"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38887">
        <property type="entry name" value="CHROMOSOME 21, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38887:SF1">
        <property type="entry name" value="RAS MODIFICATION PROTEIN ERF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM30889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="298" mass="33453" checksum="B0B7C233111A1B2D" modified="2014-04-16" version="1">MHDQKNQNPSEDRGRYHEEEAADQPPAYIAGPAIQPSRSPAQAPHQTSHKPIAIPAITSSSDSPFIRAYAPILRNHQLPKESFLSFLDQLNKDIAASPPLQVLDATGGILKSVPILFPLHWIGGVVSGLANMGSQGMSKSRTDSSIKQANRDIFRPRGLEVEIAKLDALAHVAKLPILDSQGKIDRQAPLFLQLQDGVSMANPGTDERQQQELDLQQRISTLQPWIAELEFDILPWSSKSRLTRFNASLKKYNEPEYQEKRGMGRRGDVYIQETPQEEAPFRKALWLVIREVETDERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W6QA18</accession>
    <name>W6QA18_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Indole-diterpene biosynthesis protein PaxU</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PROQFM164_S01g000441</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus outer membrane</location>
            <topology evidence="6">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TMEM53 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QA18"/>
    <dbReference type="OMA" id="DERRYWD"/>
    <dbReference type="OrthoDB" id="77878at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005640">
        <property type="term" value="C:nuclear outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008547">
        <property type="entry name" value="DUF829_TMEM53"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12265">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12265:SF30">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05705">
        <property type="entry name" value="DUF829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM26632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="286" mass="32091" checksum="857622FDF7F649A0" modified="2014-04-16" version="1">MQSVMPSTRLCANTWLSNPEKAIPGQLIIICTWLGASPKHVGKYTDLYRSIAPHARILLIESDVSILVSSYARQRRRIRPVVDIVLETLAETETSSDDNAPRILLHTFSNGGTNTATQLLIILREVASKPLPLIGLVLDSTPAKGTYWKSYNAMVFSLPPASRFVGSMVVHCLLVLLYTWIACGNENPASLMRRTLLDKDTVGPAPQRPDPEARGYIYYMYSKEDRLTDWMDVWEHAGKAREEGWKVKEVVFKGTGHCAHMPFDPMRYTECVEQAWGAISKPESKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W6QA32</accession>
    <name>W6QA32_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g000456</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QA32"/>
    <dbReference type="OMA" id="QGSWNQW"/>
    <dbReference type="OrthoDB" id="4356069at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM26647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="297" mass="33238" checksum="BCDDBA1374F7D750" modified="2014-04-16" version="1">MKDWLKAMATFMKKFKRKRRVSTELHSRWGDVSITYPTQGSWNQWDQSSGFVANAIASTNIQPEANQQYPSAGPLRQPSSSASSRRSRSTGIREHQVGDAPSFPTGYFDQNIRRRVGDRDTNTPPGPGLGLRDLRRGPNRRPSSSIDNDECTTDESCEEEEEREERDTPGPRIELSPREYGTGDVSHRTRDDPEDFDTPARSPPLSVTSRMRRCSLQSCATEPTTSVSGGNNSRRTSFTAASSISAPSMPPCTPQVAYNALKQPPFPEKRYPPRTKHREPESAPPQEMVPSYDELYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W6QA57</accession>
    <name>W6QA57_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S03</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S03g000277</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QA57"/>
    <dbReference type="STRING" id="1365484.W6QA57"/>
    <dbReference type="OMA" id="LVELTPC"/>
    <dbReference type="OrthoDB" id="4199986at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM33553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="143" mass="15694" checksum="56AFD30C9B954E44" modified="2014-04-16" version="1">MHQLHAQIRISPRYGGIGNLTRPFLVCNDTGSNVLTLFSSDLQALQFNMVLHIGAMRGVVQVTTANGPAFQHSMVIDMQILTSAFVPLTPWFEERAIVKPDSPGDVRLSGKAMRDYLFFATSPGNAHLYVAQKKAGIIRDLPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2024-10-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>W6QAD3</accession>
    <name>W6QAD3_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S03</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S03g000064</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QAD3"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM33340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="49" mass="5151" checksum="58B15FA3C58B98C6" modified="2014-04-16" version="1">MPPSETQGSNLIRLNRDLQIPLPDSHATPLGPKSVSPRLGVGSGLMVCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W6QAT2</accession>
    <name>W6QAT2_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sin3 binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S03g000497</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QAT2"/>
    <dbReference type="STRING" id="1365484.W6QAT2"/>
    <dbReference type="OMA" id="EDWATMG"/>
    <dbReference type="OrthoDB" id="5391991at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000432">
        <property type="term" value="P:positive regulation of transcription from RNA polymerase II promoter by glucose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018818">
        <property type="entry name" value="Stb3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28164">
        <property type="entry name" value="PROTEIN STB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28164:SF1">
        <property type="entry name" value="PROTEIN STB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10330">
        <property type="entry name" value="Stb3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM33773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="366" mass="39329" checksum="5B7954670168CCF9" modified="2014-04-16" version="1">MAFQTNSSIAMALAGKTASVDIPQRRSGLSGGRVPTRPGQPAMLPTPPNSISPTLPPQTFKHRATLSPGSPLATVPQLDSDIDLEDAEHDNSHHVSLPVEDLDSTGAITPVMLAKYHLPEILLHQGPLAIRHVMGHLTTSVPGFSHIPPAKARRLVVAALEGRGNGGVQGDVVFEKVGWGRWDARRRGEPAHDRDLNDPSSPPSSVAGSFQQRGLQIQGQSGRQGGNHHPYRMSFAESTAFSYTDDYGMHGDLDMLEHEADKMSLDGDDGEYCSSSEAPDEMQETEWVEGDDTDEEDWAQIGADALRARSMNNNGSFINGHVAARAKPQPSGIFPATCPSVAKLPPRTFDIQERAAVEALLCLGSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W6QBB4</accession>
    <name>W6QBB4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S03</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S03g000030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QBB4"/>
    <dbReference type="STRING" id="1365484.W6QBB4"/>
    <dbReference type="OMA" id="AFGVVNF"/>
    <dbReference type="OrthoDB" id="302966at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM33306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="422" mass="47882" checksum="57F3F9192538F597" modified="2014-04-16" version="1">MQWFKLLFSSQHTARQAIIHPRSYAYAHPISKAHTHTSRMALPISSPSPRIDRFGQAMESLYGSFSSIEDPKSWTPPPRSGGHRGRYLWTDAFGVINFLTMHSQYKRSDNDIVGDDRYLVLAGRLIETVHDILGRNRDGHSRLRGATDENPLSGGLRIGKTDAHGPDGDGQYHHYLTVWMFALNRMAKASGDLKYNRQAIELAKAIHPKFFVDRAAARPRMIWKMSMDLSEPMVKSEGNLDPIDGFVIFRLLQDTAIEAGDGAVLTEEIDDYRRTMERKGEHFVSSDPLDLGMTLWTAHWFSERESWAADLAGKCFDQIYNLFEINQYLERNIRFRLAFREFGTCIGIQCQPRVNAKKECSGDLKCYSDAIIAAWDPYMKLSITDDLTPEDLRPITRVMYAAALIPGAFRAGYLGKEPTPTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W6QBR0</accession>
    <name>W6QBR0_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S03g000614</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QBR0"/>
    <dbReference type="OMA" id="CEHGFRP"/>
    <dbReference type="OrthoDB" id="4272929at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM33890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="134" mass="15086" checksum="B7CD9CD5A557970D" modified="2014-04-16" version="1">MKLILSHHHHTSITMPSTQLTQVPQSVLDLSGDLEELVYTKAAIGIYDRTMLAIVNPTTTPMELNLHHGSWLQAKSKVASLHRSIVADFNRLPRQMKRTFVRANRLTLSEHGFRPSADNLEITRPGSRRAIALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W6QC67</accession>
    <name>W6QC67_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Aromatic-ring hydroxylase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PROQFM164_S03g000987</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QC67"/>
    <dbReference type="STRING" id="1365484.W6QC67"/>
    <dbReference type="OMA" id="QIDFREQ"/>
    <dbReference type="OrthoDB" id="655030at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051704">
        <property type="entry name" value="FAD_aromatic-hydroxylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46865:SF2">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46865">
        <property type="entry name" value="OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="4">
        <location>
            <begin position="4"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDM34263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="408" mass="45521" checksum="80AE5F8C7734B868" modified="2014-04-16" version="1">MALKVLICGGGVAGPALAFWLVRNGHQVVIVERSPVLRATGAQIDLRGQGIEAVKRMGLMDAVREKLVDEAGVSFIDAKGNVRGKVLANKSGKGAQSMTSEYEIMRGDLVRILYDATKDKVKYIFGQTVDGFAQNDQGVVATFSDGSSDTFDLLVGADGQGSQIRKHILPPDAPNEYHQLGVHMAYWFVPRIETDSNMCKSYLCPGGRMILTRSHNQAETQVYFTLRSDSEELRNIPKRSVGQQKQFWAERFRDAGWQADRFIEGMDTTENWFCQNVVQIKTDTWHSGRVVLLGDAAYCPSPLSGMGTSSGLVGAYILAGELARSEDLSQAFQNYHQKMRPFIDLVQPFNTGLLRWAIPNSQWEISLLHLILGLACFLRIPQLLSRFLSDRDGDWKLPDYPELEVDRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W6QCZ9</accession>
    <name>W6QCZ9_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rps-7</name>
        <name evidence="5" type="ORF">PROQFM164_S03g000665</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS7 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QCZ9"/>
    <dbReference type="STRING" id="1365484.W6QCZ9"/>
    <dbReference type="OMA" id="AAYHKVQ"/>
    <dbReference type="OrthoDB" id="1724687at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000554">
        <property type="entry name" value="Ribosomal_eS7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047861">
        <property type="entry name" value="Ribosomal_eS7_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11278">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11278:SF0">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN ES7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01251">
        <property type="entry name" value="Ribosomal_S7e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00948">
        <property type="entry name" value="RIBOSOMAL_S7E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDM33941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="200" mass="22609" checksum="8B75D6C459BC8D72" modified="2014-04-16" version="1">MAAINKIAPNSPSRQNPSELETAIAGALFDLESNTQDLKASLRPLQFVSAREVEVGHGKKAIIVFVPVPLLNNFHKIQQRLTRELEKKFSDRHVLFVAQRRILPRPKRSANSRTTQTQKRPRSRTLTAVHDAILTDLVYPVEIVGKRTRTKEDGSKTLKVILDEKERGGVDHRLDAYGEVYRRLTGRSVAFEFPQSGAEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W6QD25</accession>
    <name>W6QD25_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Unnamed protein product [Penicillium chrysogenum]</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S03g001322</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QD25"/>
    <dbReference type="STRING" id="1365484.W6QD25"/>
    <dbReference type="OMA" id="CPITNLI"/>
    <dbReference type="OrthoDB" id="1057137at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047574">
        <property type="entry name" value="AD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039683">
        <property type="entry name" value="Lsm12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019181">
        <property type="entry name" value="LSM12_ABD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13542">
        <property type="entry name" value="LSM12 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09793">
        <property type="entry name" value="AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00995">
        <property type="entry name" value="AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52001">
        <property type="entry name" value="AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AD" evidence="2">
        <location>
            <begin position="127"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS52001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM34598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="251" mass="26630" checksum="C87B4AF57DC2575A" modified="2014-04-16" version="1">MAENKRQVSVKASAQKQSGNAAGPGMATPIVALEAALSGAIGARVRISTSQPNQSTFEGTLFTACPITNLVAINTAPAPNPGDAKQAQNGDYHVIPISRIQHFQLLALAPPSNSSSSSFTDAQPTIQALDTRALKARESKAIGEALDREARRGKGVTTQAQDLFDAFSRTMPARWNGHSIIVADAVTIAAPYRVDDCRSIAEGDTAALNRVRKVLEMERKKIELRNASATIGSTSTFSRHPSVPNDQRKGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W6QD67</accession>
    <name>W6QD67_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tryptophan--tRNA ligase, cytoplasmic</fullName>
            <ecNumber evidence="3">6.1.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Tryptophanyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">WRS1</name>
        <name evidence="13" type="ORF">PROQFM164_S02g002285</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.2" evidence="3"/>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QD67"/>
    <dbReference type="STRING" id="1365484.W6QD67"/>
    <dbReference type="OMA" id="SIYHRFM"/>
    <dbReference type="OrthoDB" id="10261385at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004830">
        <property type="term" value="F:tryptophan-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006436">
        <property type="term" value="P:tryptophanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.240.10:FF:000003">
        <property type="entry name" value="Tryptophan--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000033">
        <property type="entry name" value="tryptophan--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.240.10">
        <property type="entry name" value="Tyrosyl-Transfer RNA Synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002306">
        <property type="entry name" value="Trp-tRNA-ligase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00233">
        <property type="entry name" value="trpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10055:SF1">
        <property type="entry name" value="TRYPTOPHAN--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10055">
        <property type="entry name" value="TRYPTOPHANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01039">
        <property type="entry name" value="TRNASYNTHTRP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12 13" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 12" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDM32134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="435" mass="49336" checksum="CC8CDA0A620129ED" modified="2014-04-16" version="1">MANEAIQPPALNSLSIDEKTPETKAVGQIVTPFDVSGGVDESGKLLPVDYEKLTREFGATPINAALLERFEKVTGHRPHRFMRRSIVFSHRDLSKILDKHEKGEPFFLYTGRGPSSDSMHVGHTVPFEFTKWLQDVFDVPLVIMMTDDEKFMHSQKIEIEDSKRYTKANAKDIIAVGFDMKKTFIFSDFEFIGGAFYENMCRMAKRITINQVKGTFGFNDSNNIGEFHFCATQSAAAFSTSFPHIFGTETKKVASIPCLIPCAIDQDPYFRQCREHAEKMKYKKPSLIHSIFLPALQGPGSKMSASVDSSAIFMSDTPNKIKNKINKHAFSGGQDTAELQRELGGNTKNDIPFQYLTFFLEDDEELERIRADYEGGKMMTGEIKQKCIAELQKYVQGFQERRAQVTDEIMAEYMRPRPLEWKGNPNPVVIEKAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>W6QDA1</accession>
    <name>W6QDA1_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">vesicle-fusing ATPase</fullName>
            <ecNumber evidence="3">3.6.4.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">VPS4</name>
        <name evidence="16" type="ORF">PROQFM164_S03g000765</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.6" evidence="3"/>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QDA1"/>
    <dbReference type="STRING" id="1365484.W6QDA1"/>
    <dbReference type="OMA" id="IEWTNEF"/>
    <dbReference type="OrthoDB" id="29072at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045324">
        <property type="term" value="P:late endosome to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007033">
        <property type="term" value="P:vacuole organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02678">
        <property type="entry name" value="MIT_VPS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19521">
        <property type="entry name" value="RecA-like_VPS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.80:FF:000004">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000043">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000015">
        <property type="entry name" value="vacuolar protein sorting-associated protein 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.80">
        <property type="entry name" value="Phosphotransferase system, lactose/cellobiose-type IIA subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007330">
        <property type="entry name" value="MIT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036181">
        <property type="entry name" value="MIT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050304">
        <property type="entry name" value="MT-severing_AAA_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015415">
        <property type="entry name" value="Spast_Vps4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045253">
        <property type="entry name" value="VPS4_MIT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074">
        <property type="entry name" value="AAA DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074:SF83">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04212">
        <property type="entry name" value="MIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09336">
        <property type="entry name" value="Vps4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00745">
        <property type="entry name" value="MIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116846">
        <property type="entry name" value="MIT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MIT" evidence="15">
        <location>
            <begin position="3"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="14">
        <location>
            <begin position="163"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="74"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CDM34041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="433" mass="47862" checksum="8D536BD9531FD4D6" modified="2014-04-16" version="1">MSNTDFLGRAIDTVKKAIENDNDGEYEKAYQMYYSALELFMLALKWEKNPKSKEMIRSKAGEYMDRAEKLKNHLAEDRKKPSAVGANGKVAQGSGKGGKEDDDNGEDADAKKLRSALQGAILSEKPNVKWEDVAGLENAKEALKEAVILPIKFPHLFTGKRQPWKGILLYGPPGTGKSYLAKAVATEANSTFFSVSSSDLVSKWMGESERLVKQLFNMARENKPAIIFIDEVDALCGPRGEGESEASRRIKTELLVQMDGVGKDSKGVLILGATNIPWQLDAAIRRRFQRRIHISLPDFNARMKMFMLAVGSTPCQMTQTDYRQLADLSEGYSGSDISICVQDALMQPIRKIQGATHYKKVLDEGVEKVTPCSPGDEGAVEMSWLDIDADKLLEPPLALKDFVKAVKNSRPTVSGEDLTRNAEWTQEFGSEGA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2023-06-28" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W6QDA7</accession>
    <name>ANUF_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Short-chain dehydrogenase anuF</fullName>
            <ecNumber evidence="4">1.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Annullatin D biosynthesis cluster protein F</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">anuF</name>
        <name type="ORF">PROQFM164_S03g001179</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>FM164</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2022" name="Org. Lett." volume="24" first="6072" last="6077">
            <title>Biosynthesis of Annullatin D in Penicillium roqueforti Implies Oxidative Lactonization between Two Hydroxyl Groups Catalyzed by a BBE-like Enzyme.</title>
            <authorList>
                <person name="Xiang P."/>
                <person name="Kemmerich B."/>
                <person name="Yang L."/>
                <person name="Li S.M."/>
            </authorList>
            <dbReference type="PubMed" id="35939524"/>
            <dbReference type="DOI" id="10.1021/acs.orglett.2c02438"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>PATHWAY</scope>
    </reference>
    <comment type="function">
        <text evidence="4 7">Cytochrome P450 monooxygenase; part of the gene cluster that mediates the biosynthesis of annullatin D, an alkylated aromatic polyketide with a fused dihydrobenzofuran lactone ring system that exhibits potent agonistic activities toward the cannabinoid receptors (PubMed:35939524). Within the pathway, anuF is involved in the formation of (2R)-annullatin F from the diastereomer of (2S,9S)-annullatin H (compound 12) (PubMed:35939524). The annullatin backbone 2-hydroxymethyl-3-pentylphenol is assembled from one acetyl-CoA starter unit and 5 malonyl-CoA elongation units by cooperation of the highly reducing polyketide synthase anuA, the short-chain dehydrogenase anuB and the oxidoreductase anuC, before being hydroxylated at the C-5 alkyl chain by the cytochrome P450 monooxygenase anuE to form (8S)-annullatin E. The prenyltransferase anuH subsequently installs one isoprenyl group at the benzene ring to form (8S)-annullatin J. Enzymatic or nonenzymatic dihydro-benzofuran ring formation between the prenyl and the phenolic hydroxyl groups in (8S)-annullatin J results in two diastereomers (2S,9S)-annullatin H and compound 12. The intermediate (2S,9S)-annullatin H is then converted to (2S,9S)-annullatin D by the FAD-linked oxidoreductase anuG-catalyzed five-member lactone ring formation. The isomer 12 acts as a substrate for the short-chain dehydrogenase anuF and is oxidized to (2R)-annullatin F, which is subsequently acetylated by an acetyltransferase leading to (2R)-annullatin G formation. The remaining enzymes identified within the cluster, anuD, anuI and anuJ, seem not to be involved in annullatin biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(2R,9S)-annullatin H + A = (2R)-annullatin F + AH2</text>
            <dbReference type="Rhea" id="RHEA:76427"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:195225"/>
            <dbReference type="ChEBI" id="CHEBI:195226"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:76428"/>
        </physiologicalReaction>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="4">Abolishes the production of (2R)-annullatin F and (2R)-annullatin G but not that of (2S,9S)-annullatin D and (2S,9S)-annullatin H.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.-" evidence="4"/>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QDA7"/>
    <dbReference type="SMR" id="W6QDA7"/>
    <dbReference type="STRING" id="1365484.W6QDA7"/>
    <dbReference type="OMA" id="SEMNAFW"/>
    <dbReference type="OrthoDB" id="5840532at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0521">NADP</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000458203" description="Short-chain dehydrogenase anuF">
        <location>
            <begin position="1"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="176"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="176"/>
        </location>
    </feature>
    <feature type="active site" description="Lowers pKa of active site Tyr" evidence="2">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="L0E2Z4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="O93868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="3">
        <source>
            <dbReference type="UniProtKB" id="Q92506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="35939524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="5">
        <source>
            <dbReference type="PubMed" id="35939524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="6"/>
    <evidence type="ECO:0000305" key="7">
        <source>
            <dbReference type="PubMed" id="35939524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM34455.1"/>
        </source>
    </evidence>
    <sequence length="276" mass="29146" checksum="BC50CA90F7CC4000" modified="2014-04-16" version="1">MALQLNGVAVVTGAGSGIGKAVALAYAAEGARGVVIADLNLEAALQTARESESIATSPTYRALPVAVDVTDEKSVDRMVTAAVQAFDRIDYSVNSAGIGVKHHKPVYKAEVSEMNAFWQVNVLGTLNCIKSVTKVMKSQSVSTLNKQGKSRQVGRGVILNVGSCNSYIATPDIVPYTTTKHAVMGLTKSAALDLAPHEIRVNAICPGWVNTPMVTAAINGNPDLPEMMRTIIPMSRIAEPEEIADVVLFMTSPRSSYVTGVGWVVDGGTTLQVQTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W6QDE2</accession>
    <name>W6QDE2_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Amino acid/polyamine transporter I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PROQFM164_S02g002355</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QDE2"/>
    <dbReference type="STRING" id="1365484.W6QDE2"/>
    <dbReference type="OMA" id="YCIGIGM"/>
    <dbReference type="OrthoDB" id="4476201at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015101">
        <property type="term" value="F:organic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000046">
        <property type="entry name" value="Amino-acid permease, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004756">
        <property type="entry name" value="AA_permease"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00907">
        <property type="entry name" value="2A0304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF14">
        <property type="entry name" value="GABA PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="61"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="107"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="182"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="225"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="261"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="310"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="367"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="390"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="424"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="460"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM32204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="517" mass="55799" checksum="C84989203F9EC455" modified="2014-04-16" version="1">MDKEEYNSDEAQLAQLGHKSELKRNYSLISMLGLAFAILNSWTALSASLSLSLPSGGSTSIVWGLITAGICNLCMATSLAEFLSAYPTAGGQYHWVAVTSWKKWMPILSWITGWINCSGWVALVATAGLLGSQLILGVISLMNPSYNPQRWHQFLIYIGYNIVAFLVNAFMNNIMPYVTKAAFIWSLSGFAIICITVLSCASPNYNSGEFVFTDFINETGWPDGIAWLLGLLQGGLGVTGFDGVAHMIEEIPNPSVEGPKIMIACVVIGTVTGAIFLIVLLFVAGDINEVIDSAATPLLAILKNATSSNAGAICLLIFPLVCALFAAIAIMTTSSRMVYAFARDGGLPASPFFSRVHPKLNVPLNSLYLNLALVVIFGCIFLGSSSAFNAIVSASVVLLGLSYGMPIAVNCCRGRKMLPERSFVLPEIVGWTINIISLAYILLTTILFLFPPELPATGSNMNYCVAAFGIVFIISFIQWMVDGRKNFVGPRLEMEVFQGEVAAQPEQPIPMVEHHKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W6QDW8</accession>
    <name>W6QDW8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Genomic scaffold, ProqFM164S03</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S03g001645</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QDW8"/>
    <dbReference type="STRING" id="1365484.W6QDW8"/>
    <dbReference type="OMA" id="ACSTQWT"/>
    <dbReference type="OrthoDB" id="3795566at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004879553" evidence="3">
        <location>
            <begin position="21"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="252"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="296"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="363"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="383"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="402"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM34918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="432" mass="47257" checksum="41C4DA41B2049486" modified="2014-04-16" version="1">MAPSHSFILFLSFVLSCVQAAPWIVTEVYEQDVTTDYYSEVVTEVHEITPTATLPAEALSTITSTDTIYDYTVVEKLYPTGYGTALGFDAGYDTVDSDGNYHSTIYQVNLTFSAPTACSTQWTITTAAAVTPPYEIAALLPRDNVITSTSVDSAQPFQTTTYIYEIVFVEPTQIPSPTLSSLSSYNAPTSRYIGSKCQYTDSSDYSGNSGYYTGLSSGPGTTGYSGGSSGYYDYDYDDYNWFTSTWGSGIGISYLAIVLICALGWIGIVFILGMIEAWVRFRRLMTGWQTRRGFPLFWSFILLPLSLFCLFCFRKGYRARSKEDAVILKKRWDAMSFWTKMRLFFAWGFRFKYPTVLGPAPATVKASKRPDESGPRLLDVTPPGTSAPSRAASTEVAPAAGPEMAQAPAQPHAAPEASGALPGHDVEAGPVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W6QE02</accession>
    <name>W6QE02_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NLPC/P60 domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PROQFM164_S03g001455</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C40 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QE02"/>
    <dbReference type="STRING" id="1365484.W6QE02"/>
    <dbReference type="OMA" id="ICPYVMR"/>
    <dbReference type="OrthoDB" id="2251794at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1720.10">
        <property type="entry name" value="endopeptidase domain like (from Nostoc punctiforme)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000064">
        <property type="entry name" value="NLP_P60_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051794">
        <property type="entry name" value="PG_Endopeptidase_C40"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47359:SF3">
        <property type="entry name" value="NLP_P60 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47359">
        <property type="entry name" value="PEPTIDOGLYCAN DL-ENDOPEPTIDASE CWLO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00877">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51935">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004879760" evidence="5">
        <location>
            <begin position="21"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="NlpC/P60" evidence="6">
        <location>
            <begin position="102"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM34730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="236" mass="24973" checksum="C5D81B0EF7E9C564" modified="2014-04-16" version="1">MHFISLIAFSLTTAITAVSAYPITGDTVNCRSGPGTSHTVVKTYKKAHDVKITCQTTGDSISGNNIWDKTSDGCYVADYYVKTGSNSYVTAKCSSSGSTSSTGTGKAIIAAAEKEKGLPYVWGGGGCKGPSGGGFDCSGLTQYAVCQALKKTIPRVAQDQYNSSLGKRYPRAQAKPGDLLFWATGGDCKNKVVHVGIFINDKTMINAAHTGTPVREQAIWTSYGGESICPYVMRFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W6QE99</accession>
    <name>W6QE99_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">Autophagy-related protein 17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">atg17</name>
        <name evidence="9" type="ORF">PROQFM164_S03g001075</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Autophagy-specific protein that functions in response to autophagy-inducing signals as a scaffold to recruit other ATG proteins to organize pre-autophagosomal structure (PAS) formation. Modulates the timing and magnitude of the autophagy response, such as the size of the sequestering vesicles. Plays particularly a role in pexophagy and nucleophagy.</text>
    </comment>
    <comment type="function">
        <text evidence="7">Autophagy-specific protein that functions in response to autophagy-inducing signals as a scaffold to recruit other ATG proteins to organize preautophagosomal structure (PAS) formation. Modulates the timing and magnitude of the autophagy response, such as the size of the sequestering vesicles. Plays particularly a role in pexophagy and nucleophagy.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Preautophagosomal structure membrane</location>
            <topology evidence="7">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the ATG17 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QE99"/>
    <dbReference type="STRING" id="1365484.W6QE99"/>
    <dbReference type="OMA" id="THVWRAN"/>
    <dbReference type="OrthoDB" id="1937984at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990316">
        <property type="term" value="C:Atg1/ULK1 kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030295">
        <property type="term" value="F:protein kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007240">
        <property type="entry name" value="Atg17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045326">
        <property type="entry name" value="ATG17-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28005">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28005:SF1">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04108">
        <property type="entry name" value="ATG17_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0072">Autophagy</keyword>
    <keyword evidence="3 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Autophagy protein ATG17-like" evidence="8">
        <location>
            <begin position="40"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU368080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM34351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="553" mass="60888" checksum="0A05B81ABEE1CE35" modified="2014-04-16" version="1">MASSQSSLSSIRPQAGLDEDQQSLPQVDTLISYLLGAKRSLSSISHVWRANEIVTASHSALEKSVVLCSRTGFLRRGLNGQLRLLYDVRTEVEQISYRGRDEFSLALKNLDAADARLRNTLDLLRGTIVHASFRPGDEKQKSLHDFVDERGVEELHASLKASIDRTNTARAELDTSNREFDDELQATRESLRHYHTATKLASSRLSITSSSSSASDSGLLTLSSMPGQIQSLEAHAQEMAILLEALVRHFDLCVTAVKHTDGGGAVARSITGDMPTGVDGSNDGMPNIGAEINANLNAPLDPMTDAEYQEMVAVLIKDAPEADDVVMEIQDRINEMESIFDQVQAQRDALLSISKATIDVHSHLSSLASSRLPRYISQAHNFTRVWLEENDRINTGLAELSDLHSLYDGFLNAYDSLMLEVARRRHVRQRVEKVLRDTRHKLDQLHDEDAAARDTFRAEHGDFLPSDIWHGVGLAPMQVQFTRLSGGHLDSGPVAQNAIDGPKADDYTRAVEAEVTDGSAGGEEIPDLPRDLVEEAYARVKARNKVASQMHTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W6QF37</accession>
    <name>W6QF37_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S03</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S03g001391</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QF37"/>
    <dbReference type="STRING" id="1365484.W6QF37"/>
    <dbReference type="OrthoDB" id="4280571at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM34666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="259" mass="28642" checksum="E7A1921F07AFEAC4" modified="2014-04-16" version="1">MEEGGLNEMEVSDAEEEAQQDITGKNPIENRPADGLSSPSLYPVAEDRTVDKYQSARTLSKLQPTVEDTPDNTEIDNSETLSVNDEDLLMDEDFRESDIKSALDDVVKFLQDTSYNSGTPSTSANTSVNTKSNPKRLTPVSISPTSNRSDQHKLINGKQQTNNIQETLEYKRRQILQQKRKLPARLEPHSTLYTRNLRPRLNRGKSGNQAPHDDKLTEDVGKNSSSEGVLAGSVAKSRADSSSITHLKTSVPSNSDKDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W6QFG9</accession>
    <name>W6QFG9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PROQFM164_S01g002148</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QFG9"/>
    <dbReference type="OMA" id="WNLQMNT"/>
    <dbReference type="OrthoDB" id="3897607at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF140">
        <property type="entry name" value="ATPASE, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="44"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="87"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="181"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="215"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="253"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="28"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="282"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="332"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="299"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="335"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="346"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM28337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="373" mass="41278" checksum="B3BEF5C0B24F383D" modified="2014-04-16" version="1">MLPLEGRSESIFIVTTVFLGISFIAVVLRCFVRIRLVKAFGWDDTFMVCAMLLNILFALCGITGALYGMGQRSDDLVKKGTMETAMFWWWLGQTSYVWTCSLAKISIAFALLRLTVSNPHKLVLWAVIAVTCTIGLVFWFMLTLQCQPVEFFWQRVRLYSNPHANVHGTCMELDHIIAMAYVYSITATICDLTLGLLPIALVWNLQMNIRTKSALAGILGMGCIASAAVIIRIPFLHDYKDVDFLYATTNISIWSNVEAGLGIAAGSLVTLRPLFRWFRDPSSAGGSKSKTKRTGGSIPLSSINGGRSTISGPQYWRPDLDRPDQHAVVTTIHTSNGSATSRSSSQEDLNPKNGTFFQGVNVQKTFYVSEDQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>W6QFP7</accession>
    <name>W6QFP7_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Signal transduction histidine kinase-related protein, C-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PROQFM164_S01g002288</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QFP7"/>
    <dbReference type="STRING" id="1365484.W6QFP7"/>
    <dbReference type="OMA" id="KRAAIWG"/>
    <dbReference type="OrthoDB" id="303614at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.130:FF:000023">
        <property type="entry name" value="Sensor histidine kinase/response regulator, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.40:FF:000083">
        <property type="entry name" value="Sensor histidine kinase/response regulator, putative (AFU_orthologue AFUA_4G00660)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050956">
        <property type="entry name" value="2C_system_His_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43719:SF72">
        <property type="entry name" value="HISTIDINE KINASE_RESPONSE REGULATOR, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G06140)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43719">
        <property type="entry name" value="TWO-COMPONENT HISTIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="4">
        <location>
            <begin position="564"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="5">
        <location>
            <begin position="1108"/>
            <end position="1231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="267"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="462"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="845"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="992"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1062"/>
            <end position="1103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="267"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="306"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="344"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="860"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="992"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1062"/>
            <end position="1092"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="1160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDM28477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="1236" mass="135847" checksum="E36157CD57DF398F" modified="2014-04-16" version="1">MFNPYSQTMDYEADRQKREVYRYFQPENPAALNASLFQFDEHLAAIGDFSRVTTPFVPDASASERSFVEGSSPSSPNTTLTSFAQLAALRLNAQRAFITVLNSDSQFILAEATRNTNLKSSRSSVGEGDRLFAGTSTLSDYWNICQETVAIDSDNKDGSYSFLIVNDLQREERFRGLPFVTQEPHSRFYAGTPLTSDSGINLGCLFVLDSEPRQGLSDIEKDTLGKVAELVMDYLLVSRQAAEGRRASRLSRGLHLFVDGNSSFASNAHMSSRSNSSAHSSSPQASPHLRTRQPISPQNDELEFCSAQSGPGNASRNGDAHPMSSDSNHNEMCAPPSPTESLHSSQQDDSSSEDSSSSNHWLFQRAANLLRQSLDLDGAGGVMFLEASDNSSEYVAAGHSDSAGSTDPAPILALSTRGDPFSYQASSTLSDPAVNLDNRFLKQLTRRYPKGKLWSFHRDGTFSTSEDQSTDDSRKQRKKTKASETSKLNEFFPAASQIMFVPLWNATDSQWFAGCFCWTPRPTRVFSPAVDLSSVFAFGSSIMTEYSRVESVIADRQKGDFISSISHELRSPLHGVLAAAEFFGSTTLDQFQETLLDTINACGRTLLDTMNQVLDFSKIMSLERHKKTFRRGKDPWKPKSSEDTVPRLDTLVLTDVALLTEDVIDSVCLGHSHIQKSAISTNRATDILSTLPSKSTSNTNKVGHISGVDVVVDIPDNDWMYKVQPGSLRRLIMNILGNALKYTEKGRISVCIEATERSKGRSRRQGLEDMVTLTVSDTGKGISKQYLQKNLFIPFSQEDPLSVGTGLGLSIVRGIVKTLNGKINIRSRQGEGTIVKVSLPLERLVGEESPQSTSERENSDQNILTASSQPRRASCNGKRAAIWGIDLSHLGENQFWASMARYITDWYGLRLVPLSTNEPIDILFADERDLSTKEIHNFPPELPSLLVFCSETSDYGESRAQWSHLAGTLAILHRPCGPRKLSRGILSCLNTNPTAPTLKPQNPRQGLVFPERPNPTGSALPIRQSNPSLPRNLRSPDAEPPIPMAASGNCIIGLTGRSAFVSTSRTDSSGRTTSGSTDSTNPGSLSTRSSSDGSDHVTPLIGSQSRPRVLVVDDNNINLHLMMTLMNKRKVMVLDKAENGRAAVDAVERMLQGYDLIFMDMSMPVMNGFEATRAIRAIEKERSDCMPATIIALTGLSSTRDEFRALDSGVDLFLVKPVSFRELSRLIDEWEAKLPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W6QGH5</accession>
    <name>W6QGH5_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pyruvate dehydrogenase E1 component subunit alpha</fullName>
            <ecNumber evidence="5">1.2.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">PDA1</name>
        <name evidence="7" type="ORF">PROQFM164_S04g000411</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[protein] + pyruvate + H(+) = N(6)-[(R)-S(8)-acetyldihydrolipoyl]-L-lysyl-[protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:19189"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10478"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83111"/>
            <dbReference type="EC" id="1.2.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="1.2.4.1" evidence="5"/>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QGH5"/>
    <dbReference type="STRING" id="1365484.W6QGH5"/>
    <dbReference type="OMA" id="LGYEMPC"/>
    <dbReference type="OrthoDB" id="10256198at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004739">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006086">
        <property type="term" value="P:pyruvate decarboxylation to acetyl-CoA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02000">
        <property type="entry name" value="TPP_E1_PDC_ADC_BCADC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000013">
        <property type="entry name" value="Pyruvate dehydrogenase E1 component subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050642">
        <property type="entry name" value="PDH_E1_Alpha_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017597">
        <property type="entry name" value="Pyrv_DH_E1_asu_subgrp-y"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03182">
        <property type="entry name" value="PDH_E1_alph_y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11516:SF60">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE E1 COMPONENT SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11516">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE E1 COMPONENT, ALPHA SUBUNIT BACTERIAL AND ORGANELLAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 5 7" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Dehydrogenase E1 component" evidence="6">
        <location>
            <begin position="80"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM35530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="405" mass="45165" checksum="1EACE465D786E157" modified="2014-04-16" version="1">MLFRAAVRQAAPLRRHAFTPLARRTVTTDAASANVESPLPDEDHKLFTVRLSDESFETYELDPPPYTLETSKKELKQMYYDMVAMRRMEMAADRLYKEKKIRGFCHLSVGQEAVAVGIEHAITRKDKIITAYRCHGFAMMRGGTVKSIIGELLGRREGIAYGKGGSMHMFAENFYGGNGIVGAQVPVGAGLAFAQQYNEEPNTSIVLYGDGASNQGQVFEAFNMAKLWNLPVLFGCENNKYGMGTSAARSSALTEYYKRGQYIPGLKVNGMDVLATKAAVQYSKNYAITGNGPLVLEYVTYRYGGHSMSDPGTTYRSREEIQRMRSTNDPIAGLKQKMLEWGVVSEEELKGLDKTARANVDAEVAEAEAMAVPDNTPRILFEDIYVRGSEPKWMRGRTVDETFYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W6QGJ8</accession>
    <name>W6QGJ8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S04</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S04g000834</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QGJ8"/>
    <dbReference type="STRING" id="1365484.W6QGJ8"/>
    <dbReference type="OMA" id="SADWQQW"/>
    <dbReference type="OrthoDB" id="9975114at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="334"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="383"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="455"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="556"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="732"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="33"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="336"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="468"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="556"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="585"/>
            <end position="615"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM35953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="873" mass="96701" checksum="BB202418A7289C8E" modified="2014-04-16" version="1">MFSSTSNTRNLRRSMSTRSIRKPRRLAPEIPDAAVQHAAAAAAASRAMRSSQGSSQDSKSSYERLGGPGNFAIPRRRHGSSLRSTDDGSSVGQGDFPKAPNPRQSKELTGVSARAHCFDDPAALPPITELDGLDGRDSSVPSSYRRLRKAKSMFSTSQRTSQTPYGVPTLPCSDPLDPERSPGFQLPRTMRRSMSFLRGSYQSNQVAPTSKGHDAAIQLARSQFAQDPDAGGVQTRRPSFLLRRKKEHRPFRKSFRATSESGVDTGRSLKSRSFSNSIKNKFKRVFGFSRLDQQPGSPNASMVTPARKSIEGFSPNKVSAIGDGTDSNYFRPMPQSPSQESLCTSKSRVTSWADSTTPNTVTTRKLGHRQSLSLIREDGLNQQIPRTPTMDDTENQSPLAARANPHRISIVDSQDLYTALMKQMGQNSLPNSNEDMVFGNVSQHRVIPERVNSVYSQHGRRSIRHVPSQESSTSPGSFATARGGDQSSPRKYPRSVRSMQVSRGMPSQMKDQHMTAVSDAKSPQSAYAFCEESDDDNGSVIVSRLRASTRDIVSPSVYSRTTSGNTPTRTDNTDIGVHDEPGTATIFTSQRTTYSSPKRTNRASSSTPNVKPSADWQQWMSSQIERIEQASPTREHVRECAQYQDDDEYFTSIARRAPVAVSAPGSATVLRVPDCQSITERKASAENRILSQSNFSRPLTQASSMRTIMPLQTTKSENMVQSYANSVSLDTAAKSGENDSPKSIPVACNQQPSPIRLRSGNMQPPESPTPKGVGAKRSLTKEQQRRYSSRRAPISQDNRINHFRSIRTQRDNRVNNENARQQDEYNDMMESYHQLQDIHSTISSKRMVDMFLDSRRRQMGEVTDNDTTTEAFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>W6QGQ5</accession>
    <name>W6QGQ5_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Adenylate kinase</fullName>
            <ecNumber evidence="6">2.7.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">ATP-AMP transphosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">ATP:AMP phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Adenylate kinase cytosolic and mitochondrial</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Adenylate monophosphate kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ADK1</name>
        <name evidence="9" type="ORF">PROQFM164_S04g000501</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>AMP + ATP = 2 ADP</text>
            <dbReference type="Rhea" id="RHEA:12973"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.3"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
            <location evidence="6">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Mitochondrion intermembrane space</location>
        </subcellularLocation>
        <text evidence="6">Predominantly mitochondrial.</text>
    </comment>
    <comment type="domain">
        <text evidence="6">Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the adenylate kinase family. AK2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.3" evidence="6"/>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QGQ5"/>
    <dbReference type="STRING" id="1365484.W6QGQ5"/>
    <dbReference type="OMA" id="VYHEQTA"/>
    <dbReference type="OrthoDB" id="439792at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:AMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006172">
        <property type="term" value="P:ADP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046033">
        <property type="term" value="P:AMP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046034">
        <property type="term" value="P:ATP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01428">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000106">
        <property type="entry name" value="Adenylate kinase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00235">
        <property type="entry name" value="Adenylate_kinase_Adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03168">
        <property type="entry name" value="Adenylate_kinase_AK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006259">
        <property type="entry name" value="Adenyl_kin_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033690">
        <property type="entry name" value="Adenylat_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007862">
        <property type="entry name" value="Adenylate_kinase_lid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028587">
        <property type="entry name" value="AK2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01351">
        <property type="entry name" value="adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001380">
        <property type="entry name" value="PRK00279.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001381">
        <property type="entry name" value="PRK00279.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF011100">
        <property type="entry name" value="PRK14527.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="NUCLEOTIDE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00406">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05191">
        <property type="entry name" value="ADK_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00094">
        <property type="entry name" value="ADENYLTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00113">
        <property type="entry name" value="ADENYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Adenylate kinase active site lid" evidence="8">
        <location>
            <begin position="170"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="NMPbind" evidence="6">
        <location>
            <begin position="72"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="LID" evidence="6">
        <location>
            <begin position="169"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="52"/>
            <end position="57"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="99"/>
            <end position="101"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="128"/>
            <end position="131"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="179"/>
            <end position="180"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM35620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="257" mass="28465" checksum="612FDCBF9AFBB26F" modified="2014-04-16" version="1">MAPITEDALSGLKNTIHQLEAKVSELENRLANGGKPKSVAEQMRIILMGPPGAGKGTQAPKLKEKFCACHLATGDMLRSQVAKKTDLGREAKKIMDQGGLVSDEIMINMIKSELDNNSECKNGFILDGFPRTVAQAERLDDMLTARDQKLQHAIELQIDDSLLVARITGRLVHPASGRSYHKIFNPPKDDMKDDISGEPLIQRSDDNAETLTKRLSTYHAQTTPVVEYYKKTGIWRGIDASQEPGQVWKSILGVFRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W6QHD0</accession>
    <name>W6QHD0_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glutamine amidotransferase type 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S05g000056</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QHD0"/>
    <dbReference type="STRING" id="1365484.W6QHD0"/>
    <dbReference type="OMA" id="LQMIHGD"/>
    <dbReference type="OrthoDB" id="1669814at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01741">
        <property type="entry name" value="GATase1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044992">
        <property type="entry name" value="ChyE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42695:SF6">
        <property type="entry name" value="GLUTAMINE AMIDOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42695">
        <property type="entry name" value="GLUTAMINE AMIDOTRANSFERASE YLR126C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM36223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="333" mass="35816" checksum="F4215E66E065A478" modified="2014-04-16" version="1">MAQRMIHVAALDADIPCLSVYKARGLYSSHFRVLLQAAAERLNKNPETLRNGPLAIHITAFDAVGGSLPPLETLRTKPQSPAELHAGPLSPIDAILITGSAASAYEDQPWIHAMQSFIRTVHTHYPNIKLFGSCFGHQIIAQALLSNIANPIHSPISTFHVEHSPAGFEMGIQPITLQPSFTAHFPPLARATAQHPFRIQLIHGDAVVPTPEAEAAADDAGVALPEPWSSIGNSAQCAIQGLYNPGRVLTYQGHFELDTFATGELAQEFGRRAGWSAAVVGGYLEQIYRSRIPGFEDDDDSKAAAEAVLLFFAGEDVDSMCGIDTGMITPPLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W6QHP6</accession>
    <name>W6QHP6_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S04</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S04g000831</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QHP6"/>
    <dbReference type="OMA" id="CADCVQL"/>
    <dbReference type="OrthoDB" id="3911301at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM35950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="64" mass="7232" checksum="0716DEA2056DA7CE" modified="2014-04-16" version="1">MYSCANYPRGCRGRVNRQGAKCSDCVSLNLRRPASPFAQPREYKRALPSELFGELSKLSEPKLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W6QI07</accession>
    <name>W6QI07_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Genomic scaffold, ProqFM164S04</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S04g000941</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM36060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QI07"/>
    <dbReference type="OMA" id="ENICLIH"/>
    <dbReference type="OrthoDB" id="5416097at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13391">
        <property type="entry name" value="HNH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HNH nuclease" evidence="2">
        <location>
            <begin position="118"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="298"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="82"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM36060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="319" mass="35707" checksum="972109391288C701" modified="2014-04-16" version="1">MKTAIKTQFLPHYIDVPGQYKYIEDDFYNTKLAIRLVIGAGRKQPKPEKPEKPAKGQKREADDVPVDESSSPGKRLKGPPASMSGEEPMGSSEQATRGVLLRGKAVRDAALTRDGNACVLTKFGIHGLHVSHILPFKLNNSSREIEWSILEGFWGVDRVMKWKAEIMTIDDNDGKVDTERVQNLITFMALVHTYWDNTLYALRPISINTKKTSMEVAFHWLPAPGKITRKASDSIETMQHPFPHDINSFTESPGENICLIHGETRTLETDDPESKPLPSMELLELQWIRHRIAAMRGAAEDDESEIDSDDDSVCVPSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W6QI10</accession>
    <name>W6QI10_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Splicing factor subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S03g000538</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the SF3B5 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QI10"/>
    <dbReference type="STRING" id="1365484.W6QI10"/>
    <dbReference type="OMA" id="YDRFNIH"/>
    <dbReference type="OrthoDB" id="274726at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009846">
        <property type="entry name" value="SF3b5/RDS3-10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017089">
        <property type="entry name" value="Splicing_factor_3B_subunit_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20978">
        <property type="entry name" value="SPLICING FACTOR 3B SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20978:SF0">
        <property type="entry name" value="SPLICING FACTOR 3B SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07189">
        <property type="entry name" value="SF3b10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037010">
        <property type="entry name" value="Splicing_factor_3B_subunit_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR037010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM33814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="84" mass="9432" checksum="786706F7373C8CC3" modified="2014-04-16" version="1">MADKLRTIQNLEALQARYIGTGHADTTKYEWTSNILRDSYSSYVGHPPLLSYMAVGMGEPKEKVRAMMLEKMVRGAGNPPETQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W6QI73</accession>
    <name>W6QI73_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="12">SUN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PROQFM164_S04g000597</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SUN family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QI73"/>
    <dbReference type="STRING" id="1365484.W6QI73"/>
    <dbReference type="OMA" id="CSYACQS"/>
    <dbReference type="OrthoDB" id="5339822at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051526">
        <property type="entry name" value="Beta-Glucosidase_SUN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005556">
        <property type="entry name" value="SUN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31316">
        <property type="entry name" value="BETA-GLUCOSIDASE-LIKE PROTEIN NCA3, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31316:SF0">
        <property type="entry name" value="SECRETED BETA-GLUCOSIDASE SIM1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03856">
        <property type="entry name" value="SUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0134">Cell wall</keyword>
    <keyword evidence="9" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004879620" evidence="11">
        <location>
            <begin position="27"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDM35716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="442" mass="45736" checksum="2D483706EE27A01F" modified="2014-04-16" version="1">MYFRTTTTMKFLNTVAALATAGLAAAHGHGHGHVHKRAAETEASAAGPVVYDFVVMDPSSSSDPQSISIEEACAGLANHEFEWLDSAVAAACPSSSSAAPTSTSASSSTSAPTTTATVAPAILQETSAVIILASSTSSAVATSSSTTAAAATSSSSSSSSSGATGLTADFPDGEIDCGDFPSDYGAIALDYLGLGGYSGIQYVTFLDEVISDIVTAVTGDECHHGAMCSYACPPGYQKSQWPSVQGSTGQSVGGLQCKSDNKLYLTNDNYKQLCIPGVGGVHVKNQMSDNVAVCRTDYPGTESETVPLSAVPGVVHDLTCPDGEDYFLWEGKVTSAQYYVNPKGVSTEKGCQWGDGTESIGNWAPINLGVGYTSSGKFLSIFPNTPTTTKALDFNVKLEGDDLSDECRYEDGKFYDSNGLISGNSGCTVGVTSGKAYYVFYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W6QIY2</accession>
    <name>W6QIY2_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MmgE/PrpD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S01g003364</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PrpD family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QIY2"/>
    <dbReference type="STRING" id="1365484.W6QIY2"/>
    <dbReference type="OrthoDB" id="10267976at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4100.10">
        <property type="entry name" value="2-methylcitrate dehydratase PrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036148">
        <property type="entry name" value="MmgE/PrpD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042183">
        <property type="entry name" value="MmgE/PrpD_sf_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005656">
        <property type="entry name" value="MmgE_PrpD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045336">
        <property type="entry name" value="MmgE_PrpD_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16943:SF8">
        <property type="entry name" value="2-METHYLCITRATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16943">
        <property type="entry name" value="2-METHYLCITRATE DEHYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03972">
        <property type="entry name" value="MmgE_PrpD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103378">
        <property type="entry name" value="2-methylcitrate dehydratase PrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MmgE/PrpD N-terminal" evidence="2">
        <location>
            <begin position="4"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM29552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="252" mass="26047" checksum="6320897560BA87CD" modified="2014-04-16" version="1">MATQNLATWTVSLSYPDLPGEVIDAAVRSFYNIAGCIVGGSQHIATSTARKALSPFAGPPTSHLPGTSTSTDAMHAALFNGIASHVHDYDDTHLDTVIHPTGPVACALLAILPTLPRPVSGPEFITALVAGIEAECKVGLAVWPAHYDVGWHITSTTGSIGAAVAVAKLLALSAEQVAHAIGLAATQVTGLREMFGSHAKSFHPGRAAQNGLLAALLAREGFTSSVQALEAKRGWANVVCAGGNRIEEEECV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W6QJ32</accession>
    <name>W6QJ32_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Carbon-nitrogen hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S04g000907</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM36026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QJ32"/>
    <dbReference type="STRING" id="1365484.W6QJ32"/>
    <dbReference type="OMA" id="VKILCWD"/>
    <dbReference type="OrthoDB" id="201515at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008418">
        <property type="term" value="F:protein-N-terminal asparagine amidohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070773">
        <property type="term" value="F:protein-N-terminal glutamine amidohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07566">
        <property type="entry name" value="ScNTA1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039703">
        <property type="entry name" value="Nta1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11750">
        <property type="entry name" value="PROTEIN N-TERMINAL AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11750:SF26">
        <property type="entry name" value="PROTEIN N-TERMINAL AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM36026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="372" mass="41309" checksum="D6B747C74057C18C" modified="2014-04-16" version="1">MRIATLQFAPKLGDLKGNIEKANALLKTGKTVALDGKELGVGVDLLKPDILVLPELAMTGYNFPSLEAIKPYLEPAGDGPSASWARETARRLRCKVCVGYAEIENDSQNSDKVTYYNSLLVVDENGEFILNYRKSFLYYTDETWAAEGQVERGFHELEFGSQGALSSLHQGEQVLSEKKRIATSFGICMDINPYKFEAPFTKWEFATRVLDSKSQLVILSMAWLTTLSREELDALKDKPEMDTFNYWLQRFWPLIQKRMEHEVDIDGGEAADSPKKIVIVFSNRSGEEPPTEDTKPPARYAGTSAIIAVTQRPTVNVDAGSGAHAPDEESETKDAGIPFDIKILCWDMLGAAEEGICFADTTADPQMVFALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W6QJP2</accession>
    <name>W6QJP2_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">3CxxC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PROQFM164_S05g000064</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QJP2"/>
    <dbReference type="STRING" id="1365484.W6QJP2"/>
    <dbReference type="OMA" id="YPELHGY"/>
    <dbReference type="OrthoDB" id="8121437at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027377">
        <property type="entry name" value="ZAR1/RTP1-5-like_Znf-3CxxC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13695">
        <property type="entry name" value="Zn_ribbon_3CxxC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01328">
        <property type="entry name" value="zf-3CxxC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="3CxxC-type" evidence="4">
        <location>
            <begin position="129"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDM36231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="249" mass="28644" checksum="825CB30B160FDCD4" modified="2014-04-16" version="1">MAEDWLIGSRKCKNHSTWYFEIGQTGVQVAAINQLSHSSNYPYQLLSDLLTLTRILHQGQKNILIVSFFQLLYMPHKMVPAKNKKPIAKWSMYPALHDEVSTLLVEENLHFKFHEDDNDARRIRDHDTNIMGRFVCHNPGCKSKGWSSKMIAVTIRLYPGQEYNARVYHQHCKTCSWVSRPVLDQSYAERIVYRIKKWNGVPVETISNSGSSRGPHNRKLCEGCKAGHCSQSRENAGVDFIAQLERLTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2024-10-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>W6QKC8</accession>
    <name>W6QKC8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S03</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S03g001404</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QKC8"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM34679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="50" mass="5451" checksum="3F9A29ABD94D84C7" modified="2014-04-16" version="1">MVLSKQLIRSNVIGKRAATDHLSEHLLILCPIFPHPLHLGAARGRGSNPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>W6QKE4</accession>
    <name>W6QKE4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cell division cycle protein 20 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">Cdc20</name>
        <name evidence="10" type="ORF">PROQFM164_S03g001414</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat CDC20/Fizzy family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QKE4"/>
    <dbReference type="STRING" id="1365484.W6QKE4"/>
    <dbReference type="OMA" id="PVKSHHG"/>
    <dbReference type="OrthoDB" id="10263272at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010997">
        <property type="term" value="F:anaphase-promoting complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990757">
        <property type="term" value="F:ubiquitin ligase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905786">
        <property type="term" value="P:positive regulation of anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000098">
        <property type="entry name" value="WD repeat-containing protein slp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033010">
        <property type="entry name" value="Cdc20/Fizzy"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056150">
        <property type="entry name" value="WD40_CDC20-Fz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918">
        <property type="entry name" value="CELL DIVISION CYCLE 20 CDC20 FIZZY -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918:SF8">
        <property type="entry name" value="FI02843P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24807">
        <property type="entry name" value="WD40_CDC20-Fz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 10" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 7" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="CDC20/Fizzy WD40" evidence="9">
        <location>
            <begin position="302"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="347"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="430"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="561"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="121"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="602"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="90"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="121"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="131"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="615"/>
            <end position="624"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF24807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDM34689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="624" mass="67248" checksum="E59ED83748F6C006" modified="2014-04-16" version="1">MASVTASTPVKSHHGLFSSKTAGGRMPLSPSPNPRVSGHSSPFTPPPRQSEAGRSQTKSVYGGNLSAHFAKSISKAAQAARTTHRESPKATKSNKSNIAITRTRKSPKHLELGVSDWTLTGTSATTANTPTKEHVRREIPTRSRTSKTTVRIPHNAGDRFIPNRTASEGLATSGAAKPEEKQRPKSGAADGSSVLASAVSAFDIGTRGSDDDLTAALESLGLDDNDPPTYTRPAPDAVAYKSSLAEACGVNMNTRILAFKPPPPESSKPIDLRAQYNRPLRPAKSTSAQFRRRVQTAPERVLDAPGLLDDYYLNLLDWSSGNQVAIGLERNVYVWSAESGSVNCLLETSPDTYVSSVKWSGDGAYVGVGLGTGEVQIWDVEEGSKLRSMYGHDSRVGVMGWNKHTLSTGARSGLVYNHDVRIAEHKIAELVSHTSEVCGLEWRSDGAQLATGGNDNLVNIWDARSLSAPKFTKTNHRAAVKALSWCPWQSNLLATGGGSYDRHIHFWNTTTGARTNSIDTGSQVTSLRWSNHYREIVSSSGFPDNSLSIWSYPTLVRNVEIPAHETRVLHSAISPDGQMLATTAADESLKFWKIFERKAGSSASSSREGGVGSKAQMTKSMTIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W6QKW6</accession>
    <name>W6QKW6_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S06g000050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792020">
        <property type="protein sequence ID" value="CDM37090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QKW6"/>
    <dbReference type="STRING" id="1365484.W6QKW6"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM37090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="160" mass="17473" checksum="CBE98DC1CF14DAAA" modified="2014-04-16" version="1">MVCGQYRVLSLGVGLNLAPYSMTQYIIHNKMPKHPDLQAVDCDGYVHAEGTIKLEQDLHVLREKPLSSDIKVAAKKKPYLKVVYDLSRRCRFVPAKMSDISSDDLPLSTASVVASSIPPAPTTSLQPGATRMMVAGEDTGEIGTQGKLTVDDNPRRNFTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W6QLC6</accession>
    <name>W6QLC6_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major facilitator superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PROQFM164_S02g000501</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QLC6"/>
    <dbReference type="STRING" id="1365484.W6QLC6"/>
    <dbReference type="OMA" id="ARVCTFA"/>
    <dbReference type="OrthoDB" id="1935484at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000247">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000106">
        <property type="entry name" value="MFS transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF104">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="207"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="240"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="355"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="383"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="412"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="479"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="78"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="22"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM30352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="534" mass="60165" checksum="7BF78914268641E7" modified="2014-04-16" version="1">MSINGIKTAHISASSSDGSDEEWQKSGRNKGEGTFESREGHHFYRPIDSYEGLHRWDPNFQWTEQEEKKIVRKIDARVCTFACVTFFALQLDRGNISQALASTLLEDLGMTSNDYNLGQTVFLICFLLAEMPSQLLSKRIGPDRWIPIQIVAWSLVAACQAFLKGRGSYLACRALLGFLEGGFIPDTILFLSFFYKSSELPKRLTCFWISYTVAGIIGSFLAFGFLHIKDANGSGAWRYLFAYEGLITGVIGIIAAFWMPASPVQTKGGLRGKDGWFTEHEEKIMVNRVIRDDPSKGSMHNRQAVTPRRFWESLKDYHVWPIYALGLIWMIPSTPSQNYLTLQLRSQGFTTFQTNLLTIPAAVIAIITMIAITWVAERTNQRLLWGAAAEVWNLVLLIALELLPQKSMPWPRWAILTLLVGGPSIHPVVVALTSRNAGSVRTRTVASALYNMSVQVSNIAGANVYQAKDAPYYKKGNKVLIALAVASGFLFIFAKFYYDWRNSQNSAKWDAMTSEQREIYLRENPVLTNKRYVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W6QLH4</accession>
    <name>W6QLH4_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxymethylenebutenolidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S07g000041</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792021">
        <property type="protein sequence ID" value="CDM37693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QLH4"/>
    <dbReference type="STRING" id="1365484.W6QLH4"/>
    <dbReference type="OMA" id="PSNQMFE"/>
    <dbReference type="OrthoDB" id="5440at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030638">
        <property type="term" value="P:polyketide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009959">
        <property type="entry name" value="Cyclase_SnoaL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38436:SF3">
        <property type="entry name" value="CARBOXYMETHYLENEBUTENOLIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38436">
        <property type="entry name" value="POLYKETIDE CYCLASE SNOAL-LIKE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM37693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="411" mass="46011" checksum="016ECDB5DBD7B1FB" modified="2014-04-16" version="1">MTESSLSSAPVDLSPYVTIHPPLSRCGHGPGLVLIRPLCYATCQQQNKTLDPEPLKKWAEESFTVAQITVDEKSAINISSLRELLQEAECGLAERPECDTKEKVGLIVYGSKKDYAPQFEESLQGALVQGTALIAAVFFDSWHIPFFQSTIFQLSGPMEVEKKEGQTIHIYSDVCSPSFMIPGHPDFNISTAGVAHTRVVGFVKKHTGGPFFDLEKIWDEHTYYEFEARSVEKTMATMVSEPYVNHVPTLTGGIGRARLSHFYLNHFIFNNPDDTALELISRTVGTDRIVDEFIFVFTHVKQMDWIIPGIPPTGKYVRVPFTSVVNIRGDRLFHEHISWDQATVLVQLGLLPEYLPFPYALPDGSVPACGKRFEYRVPAAGAESAAKLQNEHEVPSNQMFEYKVREVDDSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W6QLM8</accession>
    <name>W6QLM8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S05g000714</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QLM8"/>
    <dbReference type="OrthoDB" id="4288160at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="44"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM36881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="192" mass="20198" checksum="125C94703C67E828" modified="2014-04-16" version="1">MPNHQGSWYDLDPSEQRRFMELIDPVLLLNSANTATSTDQGTNTAPAASTVPAASTVPATGTDQATATTQGTGTTQGTSTAAAAAQAASTSPTQGSRWKARDSSHPPDAFAETAKLLCDCHGPRAQWPLNNAELIIAPCAYQCPYCAEFNKVGRPRLMASNLRRHLAQTHIRGNPDVYGTLVVAPGVKGRGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W6QLP5</accession>
    <name>W6QLP5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NGG1p interacting factor 3, NIF3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S05g000739</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GTP cyclohydrolase I type 2/NIF3 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QLP5"/>
    <dbReference type="STRING" id="1365484.W6QLP5"/>
    <dbReference type="OMA" id="GYLWSVM"/>
    <dbReference type="OrthoDB" id="3345469at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1390.30:FF:000001">
        <property type="entry name" value="GTP cyclohydrolase 1 type 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1390.30:FF:000008">
        <property type="entry name" value="NGG1 interacting factor Nif3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1390.30">
        <property type="entry name" value="NIF3 (NGG1p interacting factor 3)-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002678">
        <property type="entry name" value="DUF34/NIF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036069">
        <property type="entry name" value="DUF34/NIF3_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13799">
        <property type="entry name" value="NGG1 INTERACTING FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13799:SF13">
        <property type="entry name" value="NIF3-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01784">
        <property type="entry name" value="DUF34_NIF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102705">
        <property type="entry name" value="NIF3 (NGG1p interacting factor 3)-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="313"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="317"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR602678-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM36906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="394" mass="42512" checksum="A9FAB2F13782068F" modified="2014-04-16" version="1">MNFLRATRRYSAMSMLKYTECSPFTNVVVSAMRKLYPEALADKSFDNTGCKLLLFSNIMLLEAPFDKSRIQKNSVLLTIDLTKAVADEAIKNQNSVIVAYHPIIFRGLKSLTLADSQQRSLLHLAQHGISVYSPHTAVDTVPGGMADWLCDVVTGNFEPTATPNANIETSLSSLYTAPTYPDSPIPAVRGPSSRALPHTMTTIHPSPPATIPEGFESAGAGRLVTFAEKQPLTELIDNIARGIGLPGGIPIAIPQGQSVDAISVRTVGMCPGSGSGVLLKGGELPDLLLTGEMSHHEALAVTERGSVVISLSHTNSERGYLRSVMQPKLLVEVKKQWEDAISESIWAIQASKTLGEAPSAAAVQIREIYRREEVAVHVSDADRDPYGIMILRGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W6QM37</accession>
    <name>W6QM37_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRM61</fullName>
            <ecNumber evidence="1">2.1.1.220</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">tRNA(m1A58)-methyltransferase subunit TRM61</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PROQFM164_S07g000252</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM164</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.1.1.220" evidence="1"/>
    <dbReference type="EMBL" id="HG792021">
        <property type="protein sequence ID" value="CDM37903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QM37"/>
    <dbReference type="STRING" id="1365484.W6QM37"/>
    <dbReference type="OMA" id="FYVGHVE"/>
    <dbReference type="OrthoDB" id="5585464at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031515">
        <property type="term" value="C:tRNA (m1A) methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160107">
        <property type="term" value="F:tRNA (adenine(58)-N1)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.330.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014816">
        <property type="entry name" value="tRNA_MeTrfase_Gcd14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12133">
        <property type="entry name" value="TRNA (ADENINE(58)-N(1))-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12133:SF1">
        <property type="entry name" value="TRNA (ADENINE(58)-N(1))-METHYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51620">
        <property type="entry name" value="SAM_TRM61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="179"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="359"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="179"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="369"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="384"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00033309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDM37903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="437" mass="47879" checksum="39ACED88B416BC0B" modified="2014-04-16" version="1">MSRLRQALQRVFGVTPTPGALRSRTIDTNFSIIKEGDRVIIHGKQPSLSKALKRGEKLQTARGAVDHESIIGKRVWDTVQARKGPNIRVSLPTLEEYVALTPRLVTPIYPQDANLIASLLDIHVNTPAAGEVQPTLEILESGTGHGSLTLHLARAIHAANTTPPPRPPRSQINYLEGRVIRPSEKDTEQTKEKPAEPVADPAQEEWDAWRAQRNAVIHTVDVSPKFAALAEKNIRGFRRGIYAGNVDFYVGPVEHWIAKQKQQRKKTGLAALTGGNPVDPFLSHVILDMPSSNLRIPHVTPMLKRDGLLVVFMPSITQIGECLQLIRDQRLPLVQEKVLELGSGISGGRTWDVRFATKKSGADPSSWTAPSDAEAASPAEADEQSTTSDAASEVSTTEEPAKEGESVLVCRPKVGVRIQGGGFVAVWRRIEERYPNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W6QMM0</accession>
    <name>W6QMM0_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major intrinsic protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PROQFM164_S06g000162</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792020">
        <property type="protein sequence ID" value="CDM37201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QMM0"/>
    <dbReference type="STRING" id="1365484.W6QMM0"/>
    <dbReference type="OrthoDB" id="3222at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015254">
        <property type="term" value="F:glycerol channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015250">
        <property type="term" value="F:water channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00333">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050363">
        <property type="entry name" value="MIP/Aquaporin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43829">
        <property type="entry name" value="AQUAPORIN OR AQUAGLYCEROPORIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43829:SF24">
        <property type="entry name" value="MIP AQUAPORIN (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="Aquaporin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="363"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="408"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="454"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="490"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="540"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="156"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="206"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="29"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="58"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="176"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="215"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="251"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM37201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="600" mass="66376" checksum="19768DF91028E779" modified="2014-04-16" version="1">MSGGRPRARSDALPQSPNRNRAASDADYTSPRRTTSPRRTTSPRRTSAEDGGVPRRFNSNTSTTQSNGSALPSLIPRTTLAQRTQGKFTLAGPDGTPQLRLAQEPFVQPGYADLNPSYEQASNARPVWSLAKPLPRVVRPSMVPTKDELLQNMANAQRPTENSDRLGLDVDPNDVEQGRIDKTSDPRKMAAQVKDARLQRENTFMSKILSGDGGSSMRQTSRMSRSSSIPGRRTSTWDMPPPDQQLPTVEEGDHPAEDEHEQEERPMSADEQFQNNQDMGARLDELLSLPEMEKGNYPEDLHPLVQELVEDEVHNNHTTWSVVRTHHREALAEGLGVFVSLTMGFAIDVSVTVAGQGNPNTTAWAWGFATMIGIYISGGVSGAHLNPVVTMVLWFFRGFPARKMPEYFAAQFIAAFCAGLVAYGIYYESIQNYLLTNADTGIINSFVTNPRESWVSHTTAFFTEFVGTSFLIVTILALGDDQNAPPGAGMNSLIVGLVITSLLMCFAYQTGAAFNPSRDFGPRLALLAFGYPNSMFTDPYWFYGPWVGCVGGGFFGAFLYDFFIFTGGESPVNYPLERTQRALTKSAMRWRRRLRLKPKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W6QMU8</accession>
    <name>W6QMU8_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein HRI1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S10g000037</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792024">
        <property type="protein sequence ID" value="CDM38223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QMU8"/>
    <dbReference type="STRING" id="1365484.W6QMU8"/>
    <dbReference type="OMA" id="IGAWRIP"/>
    <dbReference type="OrthoDB" id="4045395at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031818">
        <property type="entry name" value="Hri1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16815">
        <property type="entry name" value="HRI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM38223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="207" mass="22786" checksum="F9B81878A25E56D4" modified="2014-04-16" version="1">MAGTRIEENPKEIPLKVLFTRELDSLNEIGIVDIGNFSPQADGTDLECGEMPRADLPGEPMTAFEEVWQELLFKEGPEGAKKGISWILESDDAPLAVGEQKEVTVTKVFLGRIWGTYLALQQTQTHSGQKDQAGAWSLKRSGGEVSARREEWGSGWEEKYVIGPDAGDVPSIKDGFDGEGIGAWRIPGEKVVIKGKSFIVRVFEEIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W6QNG1</accession>
    <name>W6QNG1_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S04</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S04g000535</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QNG1"/>
    <dbReference type="OrthoDB" id="4473276at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM35654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="118" mass="13420" checksum="C1E3B51DF988A9D6" modified="2014-04-16" version="1">MLVERRPDESNVVPLHMLAEYFVKAGKYKEAEEIARPVCEWMDACSHLGKTSPQAINTRGIITRALWGQGPSRRSEAEALIANIRELVDGMGESKFCIYQKEEVRLNKEMLADLKLEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>W6QP91</accession>
    <name>W6QP91_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome b5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PROQFM164_S02g001557</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM164</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QP91"/>
    <dbReference type="STRING" id="1365484.W6QP91"/>
    <dbReference type="OMA" id="EQPVMRQ"/>
    <dbReference type="OrthoDB" id="2588832at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050741">
        <property type="entry name" value="Acyl-CoA_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083:SF28">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G10880)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083">
        <property type="entry name" value="MEDIUM-CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="9">
        <location>
            <begin position="3"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDM31407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="513" mass="57161" checksum="7B10C8C3B683FD75" modified="2014-04-16" version="1">MSSETLTRAEVAKHNTEDSLWCIIDHQVYDLTDFVDAHPGGAVVLAQIAGQDATSDFYNLHRQEVLEKYRDQLCIGVIEGEKPEVIVPVPGGLSPVPYAEPLWLRPQFKSPYYKESHRRLQKAVREFTDKYVTPEAQEKERDGTYISQELINRMAETNLLAMRLGPGKHLHGRTLLGGVVDGKEFDYLHDMIVTQELVRANARGFQDGNMAGMAISLTAVQQWLHDPVLKERINGEVLSGQKKMCLAVTEAFAGSDVAGLKTTAEKTPDGKHYIVNGTKKWITNGMFADYFVTACRTEKGFSVLLIPRGEGVETKQIKTSYSTAAGTAFVQYENVKVPVQNLLGEEHKGFLVIMSNFNHERFMMVAAVVRMSMVVVEETMKWSNQRIVFGKKLIEQPVIRQKLARMISLAESNQAWLESIAYQMCNMTYAEQAKNLGGPIGLLKSHCTQAAGEIASLATNIFGGRGITQSGMGKVIEMFHRTYKFDAILGGTEEILADLGVRQAMKNFPKSML</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W6QQ24</accession>
    <name>W6QQ24_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S15g000019</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792029">
        <property type="protein sequence ID" value="CDM38555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QQ24"/>
    <dbReference type="OrthoDB" id="4265129at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM38555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="192" mass="22232" checksum="3C002B9293C34C57" modified="2014-04-16" version="1">MASRREVIWSEWEESNLIPWLDAYRALSWKARADAYYKQHGVYRSVESLRGKMYHILRKRLHAGATPHGLGIQKRPRSIRCSVGGKASPATVPSKSPTQDTIDRCYQEEIMTQPRYTDSNNLTQTEDLRPGSAMPVPTHLRCEETQSSTQIWEYVHYVNAARKLRLRLMKYSLAAREHRTEAFDTSQVVYCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W6QQC1</accession>
    <name>W6QQC1_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mannitol 2-dehydrogenase</fullName>
            <ecNumber evidence="5">1.1.1.67</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PROQFM164_S05g000077</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>D-mannitol + NAD(+) = D-fructose + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12084"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16899"/>
            <dbReference type="ChEBI" id="CHEBI:37721"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.67"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the mannitol dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.67" evidence="5"/>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QQC1"/>
    <dbReference type="STRING" id="1365484.W6QQC1"/>
    <dbReference type="OMA" id="IVASWAR"/>
    <dbReference type="OrthoDB" id="418169at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050086">
        <property type="term" value="F:mannitol 2-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046029">
        <property type="term" value="F:mannitol dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000129">
        <property type="entry name" value="D-mannonate oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000669">
        <property type="entry name" value="Mannitol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050988">
        <property type="entry name" value="Mannitol_DH/Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013118">
        <property type="entry name" value="Mannitol_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013131">
        <property type="entry name" value="Mannitol_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43362:SF1">
        <property type="entry name" value="MANNITOL DEHYDROGENASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43362">
        <property type="entry name" value="MANNITOL DEHYDROGENASE DSF1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01232">
        <property type="entry name" value="Mannitol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08125">
        <property type="entry name" value="Mannitol_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00084">
        <property type="entry name" value="MTLDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mannitol dehydrogenase N-terminal" evidence="8">
        <location>
            <begin position="37"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="Mannitol dehydrogenase C-terminal" evidence="9">
        <location>
            <begin position="300"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDM36244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="513" mass="58220" checksum="50206D3DFA5160B5" modified="2014-04-16" version="1">MAPLKLNIKHLEQIAQAGNGPIQIPKHRFRNSSVKEGIVHVGVGGFHRAHLAVYVDQLMEKHGVTDYAICGVGLQPFDATMRDVLREQDHLYTVMERSDKGSFAHVVGCINSYLFAPDDREAVIAKMAHPDTHIVSLTITESGYYYNENSHELLSNHPDIQFDIKSGNENAPRTTFGFLYAALARRYEQGLKPFTVMSCDNMQKNGSITRNMLVSFARLRNPKIAEWISEKGAFPNAMVDRITPQTSAKDKEELAEDFGIQDAWPVVTEPFMQWVIEDQFCDGRPEFEKVGVQVVKNVHDVEQFEMHKLRLLNGSHSAIGYPGQMAGFEYVHEVMKNPNMRQLVWEMMQEEVKPLLPDIPGVSIDEYCKTLMKRFSNSKIKDQLPRICLNASGKIPQFIMPSIAEAIRESDKKQIEYPFRRLCFVAASWFLYVKGVDDHGKKFEVDDPMREELQAAAEAGHGGPDQLLNIKILFGDDLRGCKRFTDEMKKAMTDIADKGVLETLKVYFPEDTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W6QQR2</accession>
    <name>W6QQR2_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain, cyclin-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S05g000252</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QQR2"/>
    <dbReference type="OMA" id="YHIAMSA"/>
    <dbReference type="OrthoDB" id="3886018at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM36419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="508" mass="57702" checksum="3A80D7DC980799EC" modified="2014-04-16" version="1">MSTIEQCPAETIDNIVSFLNLRDICNLRLTSRGLALRVFGAPSFGSHLEQRQVDVTERSLRAVAEATAKPGRLGCFISDLVLVGVVNNTKFLTQEVKYTTGDAGHRAKQQQDLEILTRRQTEYETLHASRGDILLLSQIFRNLMAHGRRRGLRSLSLTVVVYREDAQTRLLPKDGFGWTLIWQAAADTFLTALAAFAASGIAVQRLDVYNSIERCSLACNEPSAVNFEYNMLATSLASLKTLAVSFSDRVINERTEDLGLTGDPSDTWDEHLEDELREREDIENEVYQDSTFTGLPALVQRCRGLESLELHHYQLKDLILSEEDLIFSGLNRYRERFFPYIAEMIPLPPLKRVVLRGLRVRSADILAFIQRLQPTLRELSLQHVILLDGAKFETIFGYCISEEAGLERLYLDHLLEPVVMASGAYNYRRLVYFTGEPNQEPKLRRRDLPHRGSNTVDRIGAAQIRRPIPYFSVSVPMRERGNRLGAHYPHSRPYLSLCLYGQRDYGPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>W6QSC9</accession>
    <name>W6QSC9_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Phospholipase D1</fullName>
            <ecNumber evidence="3">3.1.4.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Choline phosphatase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Phosphatidylcholine-hydrolyzing phospholipase D1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PROQFM164_S02g002538</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1,2-diacyl-sn-glycero-3-phosphate + choline + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14445"/>
            <dbReference type="ChEBI" id="CHEBI:15354"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="3.1.4.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the phospholipase D family.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.4" evidence="3"/>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1365484.W6QSC9"/>
    <dbReference type="OMA" id="DSLWTKH"/>
    <dbReference type="OrthoDB" id="14911at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004630">
        <property type="term" value="F:phospholipase D activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009395">
        <property type="term" value="P:phospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01254">
        <property type="entry name" value="PH_PLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09138">
        <property type="entry name" value="PLDc_vPLD1_2_yPLD_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09141">
        <property type="entry name" value="PLDc_vPLD1_2_yPLD_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06093">
        <property type="entry name" value="PX_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.870.10:FF:000011">
        <property type="entry name" value="Phospholipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025202">
        <property type="entry name" value="PLD-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015679">
        <property type="entry name" value="PLipase_D_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18896:SF76">
        <property type="entry name" value="PHOSPHOLIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18896">
        <property type="entry name" value="PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00614">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13091">
        <property type="entry name" value="PLDc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00155">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PX" evidence="13">
        <location>
            <begin position="452"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="12">
        <location>
            <begin position="924"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="12">
        <location>
            <begin position="1230"/>
            <end position="1257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="297"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="544"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="742"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1328"/>
            <end position="1358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1382"/>
            <end position="1415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1448"/>
            <end position="1540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1601"/>
            <end position="1632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1645"/>
            <end position="1683"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1743"/>
            <end position="1766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="16"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="67"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="132"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="223"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="300"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="341"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="545"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="571"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="594"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1328"/>
            <end position="1341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1348"/>
            <end position="1358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1396"/>
            <end position="1415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1479"/>
            <end position="1499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1602"/>
            <end position="1624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1673"/>
            <end position="1683"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00042228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00074658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00079280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDM32387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="1817" mass="205967" checksum="99002BFF2A915265" modified="2014-04-16" version="1">MSTHFRQSPIMSASSVHKDVETGSLRIDTKKQEPPLASNKSKLASPLPSPTESKKPASIKQVQPTTDGHETDATIGDKENTHPSSLNQGSPRGRPSLGTQPPNQSAEDQQWRYQRQSSKPRMSPPSRPPSVHFRDTDTEAPDASHSRPPSRPVSRPASQHGDDDEQGPKGKQSLFGKLKSLANAPNLAPHSRSASGASTDFRPGPSDIATPGSERGEFRFPEALEEEGSEIDADAEESGGEQPDPREKRKLQRRRKQREEEAGPNTAPTTPKTARRPSFHFSSSFAPFENYRTNLFPRRASTTDFTPQQREGVSEDEGRQRLSRRMRSRPWANTRVGSYNDHPDTNPDEQRPSNLRRFTGLAGPSGNDESLTASWRRHRAERGTSASAQRWKQIKAGLKLIGQRRKPENTVDNKKSAELLAELASAVPAALILASAFQRDEHGSRKIPILLEQLKVRVTDSRIDSHSGDRHLVFRIEMEYGSGMTRMKWIIFRTLRDFANLHLKYKLHLGTQKYIQLRTSENSPSLPRFPRSAFPYMRGVRGLESEFEDEDEEGGYETGAEGMSGTERPPMKKKQNQQAHQRRVSGPLPRRKSSLTNQEGDTAAGPSSTNEGVSGVRKETYPEKQRKKLELYLQKMIRFLIFRADSNRLCKFLELSALGVRLAAEGSYHGKEGFLIIQSSKGLDFRKALTPALVKKRHSPKWFLVRHSYVVCVDSPEEMNIYDVFLVDAWFKVQTPKLSLRKQNPRDIAKSAKQSARHPQHHTLRLENSERKLKLLARNERQLQQFEDSIRFMSANTPWMQPNRFDSFAPVRQNCFAQWLVDARDHMWVVSRAINQAKDVIYIHDWWLSPELYMRRPAAISQKWRLDRLLQQKAREGVKVFVIMYRNINSAIPIDSEYSKFSLLDLHPNIFVQRSPNQFRQNTFFWAHHEKLCLIDHTIAFVGGIDLCFGRWDTPQHLLTDDKPTGFETTDGPKDADQCQLWPGKDYSNPRIQDFYDLDKPYEEMYDRNVVPRMPWHDISMHVVGQPARDLTRHFVQRWNYILRQRKPTRPTPFLLPPPDFNPADLEALGLDGTCEVQILRSSSMWSTGTPDVVEHSIMNAYVKLIEESEHFVYIENQFFISTCEIEGRKIENLIGDALVERIVRAAKNEEAWRAVIVIPLMPGFQNTVDSEGGTSVRLIMQCQYRSICRGETSIFGRLRALGIEPEDYIQFYSLRTWGKIGPQKALVTEQLYIHAKCMVVDDRAAIIGSANINERSMLGSRDSEVASVVRDTDMMMSSMNGKPYLVGRFPHTLRMRLMREHLGIDVDELMEHDFATEEELRKIQVAEGSEHPVDNQERRNSASSAVERQDERDMVERRHRVQDEFLSRSEEMYSFNHDVDWEQGCNPNLKSNRKLTADPRVTENPDHRKDVEGDGADHLSAAAQAGLTVGRDSEMEPNGREALLSAIAPEGKGTVERPRSSQQKPPSTPSTPKDRRPGSSSETNPIPETNATTPSQGYGLNGASSRESETSGTGSNTAKEENEHSKHHHPSVPDPKRIFIDNDCMRDPIIDGFYLDTWQAVAEKNTKIYRSVFRCMPDSEVKNWKEYKEYATYGERFAEMQSQQGNKPAQPQQPQQKQNGSSPAGPTVSSPMSIASQMSFITPKAEGSQADPKSPQTINEKVVTGNDAGRPQSEQLAKQETLSSIDEKAALKTVSDPNLLASVPNGNGTSDDNSFVVGDDIEKARTTSPHVDYSEAVNLNLNSSHSRRRRRRATTIGSKRDPHGTDEYLDKGRAEDLLNHTQGHLIMWPYDWLEKEEQGGNWLYALDQISPLEIYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W6QT80</accession>
    <name>W6QT80_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mob1/phocein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S06g000265</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792020">
        <property type="protein sequence ID" value="CDM37304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QT80"/>
    <dbReference type="STRING" id="1365484.W6QT80"/>
    <dbReference type="OMA" id="YCCAIDY"/>
    <dbReference type="OrthoDB" id="10262609at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.30">
        <property type="entry name" value="MOB kinase activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005301">
        <property type="entry name" value="MOB_kinase_act_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036703">
        <property type="entry name" value="MOB_kinase_act_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22599">
        <property type="entry name" value="MPS ONE BINDER KINASE ACTIVATOR-LIKE MOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03637">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01388">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101152">
        <property type="entry name" value="Mob1/phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="164"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="361"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="99"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="362"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="479"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="547"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="582"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="311"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="316"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR605301-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM37304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="593" mass="66553" checksum="5B7A97D3784E9565" modified="2014-04-16" version="1">MTAAGVSPSSSPRLPSPPPFTEVQFGPQSPSVGDSFAKDTDLLGVAMGQNDGSTRRIRPGTKSANMASGPPVVPLSQLDSPFQLQEHLKAQFNKLAPQYTKLKEKYDVLMEKHEVLMKEYTEQKLKASDEADPNYDVLMKEYNVLLGEYNKQNPKGFDKMDLTSEVAEEPTEPSGIEKAKEPSRPGSEVANELTKPPKGFEETVWKYELCRFFTIEANRLIEGFFSESPPCSSQTCPEMRVNDWQYICAGAGHPEAKYCCAIDYCCHTLDWAMNILTSEKIFPSRLRLSGDQNTRNRLHDIFRRLYRFFAHAWYRHPAVFSKVDNHGGLYVFFKTVCVYYNLVSDYTIPLKAGGPDEAAAAQKREAAKKRREEVEGKETKEKPANSNNRFTILRKESDNTFGTAVESQDPALLTGATTRRHKHSPSTGSRVTTIAEDAEDLEEITSSSLHEPLKQSLEPRPVSVLEIRTPGERTVADEPIVDVEESSEELVEEPQEQPPQEIHEQPSETAEEQENSEQVEQTEQTEQTEESSSEEPATNTESAINKHATEGDENTTSHEEETPAEELKEAVEAVEEPYVAPETKHEPEKEEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W6QVK6</accession>
    <name>W6QVK6_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PROQFM164_S03g000321</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the NDUFAF3 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QVK6"/>
    <dbReference type="STRING" id="1365484.W6QVK6"/>
    <dbReference type="OMA" id="IDACHHD"/>
    <dbReference type="OrthoDB" id="20681at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05125">
        <property type="entry name" value="Mth938_2P1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1230.10:FF:000005">
        <property type="entry name" value="NADH dehydrogenase [ubiquinone]alpha subcomplex assembly factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1230.10">
        <property type="entry name" value="MTH938-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036748">
        <property type="entry name" value="MTH938-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034095">
        <property type="entry name" value="NDUF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007523">
        <property type="entry name" value="NDUFAF3/AAMDC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21192:SF2">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX ASSEMBLY FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21192">
        <property type="entry name" value="NUCLEAR PROTEIN E3-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04430">
        <property type="entry name" value="DUF498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64076">
        <property type="entry name" value="MTH938-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0830">Ubiquinone</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="45"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="45"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="74"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00049984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDM33597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="248" mass="26732" checksum="60C82AB79B940750" modified="2014-04-16" version="1">MLSPSPQLLRVLRTSLANSRRTSNLTRFCQIPSATAAPCLVSNSNTGLPSGRRNYSSPIQPTRMIPRSHAHKPVSRDRGPESKEDTQTNFDALNVLGNIPAPTTAIDACLDSGFHLNNGVKLTNGDGLLLVGGEAFAWRPWKAVQGAESDSAAKDAMLNSKGQFELDESVWGLLSLVWPKPDMLILGLGGSMFPLSPETKRHINSLGIRVDVLDTRNAAAQFNLLATERGVTEIAAAMIPIGWKARPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W6QWA2</accession>
    <name>W6QWA2_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S12g000053</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792026">
        <property type="protein sequence ID" value="CDM38444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QWA2"/>
    <dbReference type="OrthoDB" id="4364441at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM38444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="50" mass="5872" checksum="D879FCB222A62E2D" modified="2014-04-16" version="1">MLEALEAGRTKFDEYYSQADDSRENIYAISTMLAPVNKFKFFLSSDWDQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>W6QXM8</accession>
    <name>W6QXM8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type DNA-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PROQFM164_S03g001006</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QXM8"/>
    <dbReference type="STRING" id="1365484.W6QXM8"/>
    <dbReference type="OMA" id="HESLLHM"/>
    <dbReference type="OrthoDB" id="2123952at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000435">
        <property type="term" value="P:positive regulation of transcription from RNA polymerase II promoter by galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF15">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="17"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="55"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="57"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="68"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM34282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="522" mass="59553" checksum="85CD6281010FBF7F" modified="2014-04-16" version="1">MSEASDKAQAGWRIPRACQECRKRKIKCNGLTPCKTCQLRNTPCIYRDYIRHRRKKHENEEATERNSPRQASPTGVPQRTASVMNDFPNSVSATHMASPSCRMQLYYGPTSHFSLMQHIYRDLVSNPASQPEPSGGVEEAGAGLDLFSFRRIFFGTPDFHENKSLGKGDLSMMFLPYDLAKLFLSRFLSSLYHLMPLRPKIYYEQCLDKLYNSSPTDHLDAFAQAILLLAMASAALGTDHFAWGDVLFERVKASLTAFDDVNEQGRPNSAFLHLGSASRKALAAGLHKDVPHDVDQTPENIEERRVTFWSLYIYETWFCFHVGRPSSISLKDVAIEYPQDPFIRLLVQLCKTITRSVTEIYGQRHESLLHMWRVARSIADDIRGHEAHLQQALGLGLDSSIQAGSLGVRQTIFITLYYHTLLLTFRPFLIFRGHWQRERNIALNQSSTHVTNYPRETPSWLNEACNHAITAAQKTLHHLCEASRVNNLVLELRYHGYFFGNSVFTLIYEFIHNPNVAPVYLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W6R415</accession>
    <name>W6R415_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein kinase-like domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S05g000375</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6R415"/>
    <dbReference type="STRING" id="1365484.W6R415"/>
    <dbReference type="OMA" id="RIRHWNE"/>
    <dbReference type="OrthoDB" id="2156052at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="432"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="741"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="472"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="497"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="507"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="753"/>
            <end position="767"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM36542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="767" mass="88458" checksum="6941572784467381" modified="2014-04-16" version="1">MEETIAELRRQVEEQQRLREAAERREEEERQAREIERQAREEAERREEEERLAREAAERRVQPNTLSRLLDRCHNFLSQAIQVEADATLTTQGDATDPVNRLYPKHIVPWLDFPQLQEQVWGKFDRTAGFTSRPLFPSDTQIDYVVTNIQNRPIYSEASLRNFERDTVDNFVEKVIKALGDDEPLRQEFRIQGRVTFYDRANPSETSLENSLEQMNLQDARTPQRPANTRHGRGRGRGGGAAERQKRDGTTRRRNRRADQFCVHLTADERQIPVYAVEFKAPHKVTVAELVVGLHQMDLASDVIDQEGDTFEFYATRLVAAVVTQIFSYMIDSGVRYGYICTGEAFVFLHIPKDDPTIVQYFLCIPNQDVQADDELRLHRTAIGQVLAFTLQALAVEPPTQEWHDAAHDKLTTWEVEYLDVLREIPETLRKDPRASNYRPSRWKRDQKIHNTRSRARARCQPGASTPKHSSTESSGSDQESHSPSAAAASRSRSSRGLGNNRQSTRGSERTRVDRDNKQTSRKDGHSTRPYCTIACIRGMVNREPLDKKCPNWKHHGGQRHSMGPQEFTRQLHRQLTRDRDLGFEQLHVCGRTGYLVKATLLSHGYTVIIKATTVEKQHRLQAEVNNYRHLRSLQGHQIPVCLGDFQPRVSYWYHGELMTQMMILSWSGTRLQHVINHENSSFFHEERDKALIVLRSHGVVHSDGEWRNMLWDDMGGRLVVIDLEDVRWLKRPRTLAPISGNTRRGHRIGTGKNRQSLLSRSTAVCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>W6R5B7</accession>
    <name>W6R5B7_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="16">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">has1</name>
        <name evidence="21" type="ORF">PROQFM164_S05g000850</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">ATP-dependent RNA helicase involved in 40S ribosomal subunit biogenesis. Required for the processing and cleavage of 35S pre-rRNA at sites A0, A1, and A2, leading to mature 18S rRNA.</text>
    </comment>
    <comment type="function">
        <text evidence="16">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="12">Associates in the nucleolus with the 60S and pre-60S ribosomal subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="16">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the DEAD box helicase family. DDX18/HAS1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="16"/>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM37017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6R5B7"/>
    <dbReference type="STRING" id="1365484.W6R5B7"/>
    <dbReference type="OMA" id="LMEFHSQ"/>
    <dbReference type="OrthoDB" id="10259640at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17942">
        <property type="entry name" value="DEADc_DDX18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000379">
        <property type="entry name" value="RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000460">
        <property type="entry name" value="RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044773">
        <property type="entry name" value="DDX18/Has1_DEADc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025313">
        <property type="entry name" value="SPB4-like_CTE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13959">
        <property type="entry name" value="CTE_SPB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01178">
        <property type="entry name" value="DUF4217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 15 21" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="8 16" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="20">
        <location>
            <begin position="122"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="18">
        <location>
            <begin position="153"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="19">
        <location>
            <begin position="343"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="570"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="14">
        <location>
            <begin position="122"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="20"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="32"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="67"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="574"/>
            <end position="583"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="CDM37017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="605" mass="67253" checksum="6261794C2D32975F" modified="2014-04-16" version="1">MPGPVDTAKSINKRKRKHGSKAESDAAKPVEAKSSPSVTPKKSVASTPKASAEKTTKKRKVSPSPSAEEESAEEESDDAEAAEDVEVDAEEESDAEDSEAANGTDLPTLEDVRLPQTEGKLQKFTELNLSEKTMQGINDMGFTTMTEIQQRTIPPLLAGRDVLGAAKTGSGKTLAFLLPAIEMLHALRFKPRNGTGVLVVSPTRELALQIFGVARELMAHHSQTYGIVIGGANRRAEAEKLMKGVNLLIATPGRLLDHLQNTQGFIFKNLKTLVIDEADRILEVGFEDEMRQVVRILPKEERQTMLFSATQTTKVEDLARISLRPGPLYINVDHSKEHSTVAGLEQGYVVCEADKRFLLLFSFLKRNLKKKIIVFFSSCNCVKYHAELLNYIDLPVLELHGKQKQQKRTNTFFEFCNAKQGTLICTDVAARGLDIPAVDWIIQFDPPDDPRDYIHRVGRTARGAEGKGRSLMFLQPSEVGFLKHLKDARVPVVEFEFPASKIVNVQSQLEKLIGQNYYLNKSAKDGYRSYLQAYASHSLRTVFDVNKLDLVKVAKGFGFNAPPRIDIQLGASLSRDKKQEQQGRRTYGSQPKHGAGLKFKRKHND</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W6R669</accession>
    <name>W6R669_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S06g000248</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792020">
        <property type="protein sequence ID" value="CDM37287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6R669"/>
    <dbReference type="OMA" id="WWFRASG"/>
    <dbReference type="OrthoDB" id="5228066at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM37287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="115" mass="12819" checksum="71FB330A7577AA92" modified="2014-04-16" version="1">MDKAAKKVRTESSSDSGILEECKKEVTCDLCDRINWTTPSKGVQTTPPPRTVAIVVDVVQNRGAIRIFQKESGEYVDGVGTEEEGFRIIIPWRDTWRFRASGVVEVGYIIAKDAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W6R6Z5</accession>
    <name>W6R6Z5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="8">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PROQFM164_S06g000574</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792020">
        <property type="protein sequence ID" value="CDM37612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6R6Z5"/>
    <dbReference type="STRING" id="1365484.W6R6Z5"/>
    <dbReference type="OMA" id="NHTMAYT"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000078">
        <property type="entry name" value="MFS maltose transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF27">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="140"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="292"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="320"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="349"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="382"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="416"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="450"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="32"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM37612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="509" mass="55600" checksum="1B35326CEA0926C6" modified="2014-04-16" version="1">MSFKCGSTETQVDYSNSGARKSHAVNVQLIFACTVFGAASFLYGFDDKIISPVAALPDFVEKFQGPNPVTGQYVLTARNQNLVFSLPLVASVIGGLLASPLNFHLGRKWPLIIAYFISIGGGLLQVFAPNLGSFVGGRSINSVALGIINATAPLYISEVVPASIRGRCVSSMNILNLTAGVVGTVVVFRTEKIEGNLSYQIPMAVQCALPVLLLFLTVPLPESPQWLVGKGNIENARRNLRKLRGSSDDEVEDELRLMMLSEENEREIHAQTKFWHIFQREHLKRTLTAGSFFSLNQISGVILSTTYTTVFLTVLGVADVFALTIISSCCTLAGTMAAPFVIDRAGRRPTAFVGMGILFVIDAVAGGLAFDNSNKKATMAIAALSFVFNFFWASSFFSLSILMPSEMATPKLRHHTMAYTIACAQTTAVITTLVVPQLTSADAANLGAKTYLVFAACMAVIIVFFYFFMPETRGRTFAEIDEMYAAKIPMWKWRSYETSLELRAREKDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W6R8D2</accession>
    <name>W6R8D2_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Beta-mannosidase B</fullName>
            <ecNumber evidence="3">3.2.1.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Mannanase B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PROQFM164_S09g000043</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-mannose residues in beta-D-mannosides.</text>
            <dbReference type="EC" id="3.2.1.25"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycan metabolism; N-glycan degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the glycosyl hydrolase 2 family. Beta-mannosidase B subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.25" evidence="3"/>
    <dbReference type="EMBL" id="HG792023">
        <property type="protein sequence ID" value="CDM38127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6R8D2"/>
    <dbReference type="STRING" id="1365484.W6R8D2"/>
    <dbReference type="OMA" id="MFANFDY"/>
    <dbReference type="OrthoDB" id="2866996at2759"/>
    <dbReference type="UniPathway" id="UPA00280"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004567">
        <property type="term" value="F:beta-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006516">
        <property type="term" value="P:glycoprotein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000118">
        <property type="entry name" value="Beta-mannosidase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000050">
        <property type="entry name" value="Beta-mannosidase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001725">
        <property type="entry name" value="Exo-beta-D-glucosaminidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054593">
        <property type="entry name" value="Beta-mannosidase-like_N2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050887">
        <property type="entry name" value="Beta-mannosidase_GH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006102">
        <property type="entry name" value="Ig-like_GH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041447">
        <property type="entry name" value="Mannosidase_ig"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43730">
        <property type="entry name" value="BETA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43730:SF1">
        <property type="entry name" value="BETA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00703">
        <property type="entry name" value="Glyco_hydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22666">
        <property type="entry name" value="Glyco_hydro_2_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17786">
        <property type="entry name" value="Mannosidase_ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="beta-Galactosidase/glucuronidase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-mannosidase-like galactose-binding" evidence="13">
        <location>
            <begin position="12"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 2 immunoglobulin-like beta-sandwich" evidence="11">
        <location>
            <begin position="192"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="Mannosidase Ig/CBM-like" evidence="12">
        <location>
            <begin position="674"/>
            <end position="762"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00041069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF17786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF22666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDM38127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="844" mass="96366" checksum="5F69D2057A81F83C" modified="2014-04-16" version="1">MAKIIHSLSSDWSFKDRDTDEWLPVASVPSVVQQDLIANNKLDDPYIGFKELNARWVNEKTWVYRKVVEKPSVPAGSAIVLVFDGLDTFAKVKMDEQVILESDNMFLGHRVDVTKALEAEDEHTLEIEFDCALVKARELRSQHTKHKWVGFNGDLSRLAVRKAQYHWGWDWGPVLMTAGIWRAVRFEVYQARVANIWPQTQLSADHQAADVTVVIDVESVGDREYTAQFSLGLKGNEIASKTIPVSERTTQVKFPVDKPALWWPHGYGEQTLYDMSVSLLRNGEQVDQTSKKFGIRAAEIVQQPDKHGKSFFVRLNGMDIFCGGSCWIPADSLLPAVSAERYRKWIELLVAGRQVMIRVWGGGIYEDDSFYEACDELGVLVWQDFMFGCGNYPTWPKMLESIRQEAIYNLERMRHHPSIVLYAGNNEDYQVAESEGLTYNYEDKDPENWLKTDFPARYIYEKLLPDLVAKYSPGTFYHPGSPWGDGKISSDSTVGDLHQWNVWHGTQEKYQIFDTLGGRFNSEFGMEAFPHISTIDYFVENPEDRFPQSQVIDFHNKADGHERRLATYLVENLRSATDLETYIYLTQVVQAETMMFGYRGWRQQWGDERHCGGALLWQLNDCWPTISWAIVDYFLRPKPAYYAVKRVLNPIAIGVRREHHDWSVSHAQPAKTSKYELWIASNQPKTVQGSIELRFLSVNTGRDLRAPIARENITIAANGTTDIINGVLDHIAEPEPHVLAARLWVDNQVVARDVDWPQPLKYLNLSERQVEVKRQTGKSGETVLVISACKPVKCLVFKEQEGVQLADNAIDIVPGDEQTVRVTGLGSEPLRYRYLGQVSCEVVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W6PRM0</accession>
    <name>W6PRM0_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RBR-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PROQFM164_S01g000642</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.31"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.3.2.31" evidence="2"/>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PRM0"/>
    <dbReference type="STRING" id="1365484.W6PRM0"/>
    <dbReference type="OMA" id="TEHCIIC"/>
    <dbReference type="OrthoDB" id="9977870at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20335">
        <property type="entry name" value="BRcat_RBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22584">
        <property type="entry name" value="Rcat_RBR_unk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031127">
        <property type="entry name" value="E3_UB_ligase_RBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11685">
        <property type="entry name" value="RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01485">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="9">
        <location>
            <begin position="48"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDM26833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="278" mass="31646" checksum="2EEB3AF94946B15A" modified="2014-04-16" version="1">MAKSRSSIRKLLDYLERVFASKKVSEEVGLSVKHKANQKRIEKQYINSLHRCTGCFQRVPTTNLFTAPCQHQYCPSCLRRMSSTALNSPGMFPAKCCFQEIPTTALEAVMSPRNIKRYTVRWEENSIPPLERLYCPRATCGRWIPPKSPGARLGYCVCPHCRAKVCYKCGNFFHLAWSCSHDSETKATLRLAKENKWQRCSNCLYFVEKVDGCNHIICRCGHQFCYLCGQRGRCACPARGGGYEDLDTDGGDIDFNTLVAAMEQAESTDEPHWWDDEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W6PSU7</accession>
    <name>W6PSU7_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Fringe-like glycosyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PROQFM164_S01g001062</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endomembrane system</location>
            <topology evidence="8">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PSU7"/>
    <dbReference type="STRING" id="1365484.W6PSU7"/>
    <dbReference type="OMA" id="RTFWVLT"/>
    <dbReference type="OrthoDB" id="414175at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003378">
        <property type="entry name" value="Fringe-like_glycosylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10811">
        <property type="entry name" value="FRINGE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02434">
        <property type="entry name" value="Fringe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="domain" description="Fringe-like glycosyltransferase" evidence="11">
        <location>
            <begin position="243"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="45"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="45"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDM27253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="530" mass="60330" checksum="2BE4288C76B3F590" modified="2014-04-16" version="1">MPLFRMKTVFPLVALVTIGIFFFCMERYDRSAFLRFKHPIDRASFSGNKQPQVQTSAQSDSQQPASNTCEADPKLAAPLPFPEWLPRKNYTRAYFRPRHVNPRTEFHTLEEIEKPVLPPMVVMERGMVVSPENKPENFVCPEIIDVDVAADDDVEETSKLLFGLATTVDRLDRLLPSLLYSYGNTKAGLIVLVPESDDDLEKQETYFRNRGLDLTLKASPLDFTARYFGMVEAFTEHIRKHRPHTAWVGFSDDDTFFLSLPTIAEELKLFDESKKHYIGSLSEASWQVDTFGHIAFGGAGVFVSKPLLDVLMKHYEECQSWGEQPGDQKLGQCIQRFGDTPLTLWPSLYQMDMADPVDGVYESGRKIESMHHWNSWYSKDVVKMTTVSAAAGRKSVLRRWVFDQEESVSATGETLRHFWVMTNGYSLVKYTYGENVADDAINFDATEKTWPEDPRGYEDRLGPLRPAEEDGVAKDRWLLRDAFVVGENVHQFYVREEDEGHSVIEIVWLGPKGGGGGGVSDHHLRGTYQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>W6PSY8</accession>
    <name>W6PSY8_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 3 subunit C</fullName>
            <shortName evidence="4">eIF3c</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Eukaryotic translation initiation factor 3 93 kDa subunit homolog</fullName>
            <shortName evidence="4">eIF3 p93</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Translation initiation factor eIF3, p93 subunit homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">nip1</name>
        <name evidence="4" type="synonym">NIP1</name>
        <name evidence="7" type="ORF">PROQFM164_S01g000660</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the eIF-3 subunit C family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PSY8"/>
    <dbReference type="STRING" id="1365484.W6PSY8"/>
    <dbReference type="OMA" id="FRCGLIK"/>
    <dbReference type="OrthoDB" id="29647at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000300">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03002">
        <property type="entry name" value="eIF3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027516">
        <property type="entry name" value="EIF3C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008905">
        <property type="entry name" value="EIF3C_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13937">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITATION FACTOR 3, SUBUNIT 8 EIF3S8 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13937:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05470">
        <property type="entry name" value="eIF-3c_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4 7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="6">
        <location>
            <begin position="600"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="811"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="66"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="818"/>
            <end position="834"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM26851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="860" mass="95650" checksum="9016F24B6F417DE0" modified="2014-04-16" version="1">MASRFFYGSGSDSDSSSDEEEEVYRSGSGSEEDSDQDDSDSGSSSDSDEEGEEGRTGASKFLHDDSESEESEEEEKVTIVKSAKDKRLEGLESTIRLIDNAEKINDWAVIATEFDNLNRQMLKVTGPTPKVYIQAVAELEDFTNETASKQKASNKKMNASNSKGFNAVKQKIKKNNKEYATLVEKYRAGKEAFMADEVEEKPAPAPAPKPTKVERIENFAAAVAAGGEDDGFATVGRGGKTLQYTPESILKHLRVIVESRGKKNTDRADQIRTMQKLLEVATTPYQRIRTYMTLISTRFDLTATSTATYMSSEQWQAANEEYSALLSVLEENRQFLVSEAADEWEDDEKQPTVAEGETFFIPGSVVSLVEHLDDSLTKGLREIDPHTSEYIERLTDEQALYSSLVRSQLYVESLKGADKNGQDSMNRLVIRRLEHIYFKPANVIAIVEQAKDKAVLTNIESAVTATYKSGDVQSLVASICNYMFEHSDGIPRARAMLCQIYFLALHDHYYKSRDLMLMSHLTENIATFDVSTQILFNRTLVQIGLCAFRAGLIYEAQNTLGEICGSGRQKELLAQGIIMQRYSTVSPEQERLERQRQLPFHMHINLELLECVYLTSSALLEVPLMAQTSSAPELRRRMISKTFRRMLDYNERQVFTGPPENTRDGVIAGAKALAAGDWKLSASTFAAIKIWDLMPQPELIKAMLSRQTQEEGLRTYLFTYAPYYDSLSISSLATMFELEPKKIISIISRMISHEELAAALDQVNDAIIFRKGVELSRLQSQIVTLADKSTNLLESNEKTLEQRTQGMANAFQREHGPGARGGRGGRGRGGGRGGARIPQGDRRPGGQQFGGGALGAAIKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W6PSZ8</accession>
    <name>W6PSZ8_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">non-reducing end alpha-L-arabinofuranosidase</fullName>
            <ecNumber evidence="4">3.2.1.55</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">abfA</name>
        <name evidence="10" type="ORF">PROQFM164_S01g000670</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing alpha-L-arabinofuranoside residues in alpha-L-arabinosides.</text>
            <dbReference type="EC" id="3.2.1.55"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycan metabolism; L-arabinan degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 51 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.55" evidence="4"/>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PSZ8"/>
    <dbReference type="STRING" id="1365484.W6PSZ8"/>
    <dbReference type="OMA" id="PGRESDW"/>
    <dbReference type="OrthoDB" id="406864at2759"/>
    <dbReference type="UniPathway" id="UPA00667"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046556">
        <property type="term" value="F:alpha-L-arabinofuranosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031222">
        <property type="term" value="P:arabinan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046373">
        <property type="term" value="P:L-arabinose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010720">
        <property type="entry name" value="Alpha-L-AF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055235">
        <property type="entry name" value="ASD1_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051563">
        <property type="entry name" value="Glycosyl_Hydrolase_51"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31776">
        <property type="entry name" value="ALPHA-L-ARABINOFURANOSIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31776:SF0">
        <property type="entry name" value="ALPHA-L-ARABINOFURANOSIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06964">
        <property type="entry name" value="Alpha-L-AF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22848">
        <property type="entry name" value="ASD1_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00813">
        <property type="entry name" value="Alpha-L-AF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004879178" description="non-reducing end alpha-L-arabinofuranosidase" evidence="8">
        <location>
            <begin position="27"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-L-arabinofuranosidase C-terminal" evidence="9">
        <location>
            <begin position="453"/>
            <end position="631"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDM26861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="638" mass="70192" checksum="09D682215F88A22B" modified="2014-04-16" version="1">MKSGSVSCAGLATFVAMATCLAGALAKGNSSTAPVKLAVARDGGNKSSPLLYGVMFEEMDHSGDGGIHGQLLQNNGFQGTSLGLTAYAPVGDVTISQDRSKPVSKAITSSLKVEVPDGVKDYVGFANSGYNGIQVTGATYNCSFWMMGKYSGTINLRLVGSHNGSVYADHNLTVKSTHSKFTEFKTRFNTTYAPEGDNEWHLTFDGSKVAGSSLNFGLIQLFPPTFKGRENGLRHNLASFLDEVNPAFLRFPGGNNLEGLEVDSRWKWNTTIGPVVDRPGRESDWFYPNTDALGLDEYLWWCEDMNMAPLLAVWSGKSYGDILSGPDLEPFVHDIMNEMEYLFGDSSTHYGKLRAQNGRKDPWKVDLIEIGNEDDLTRGCDTYPDRFNQIYKAIHDKYPHITFVASNGDYSCLPSPLPENVIIDLHLYRAPDDFVKLFDQFDNQPRNQSVMIGEFGCRNTTKETGTYWPYMQGSCSEAVYMIGIERNSDIVKMVAYAPLMQHFDFVSWSPTLYGFSSTPDSVTPSVSYFVQKMFASNKGDTILPVHSSTGFGPLYWVASKTGSQYYLKLANYGPEHQNVQVSIPGTQTGKLEMLAGPKYQGNTPFNVQIQTTTTGVFNGQGNYSISMDPWAVAILAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W6PT48</accession>
    <name>W6PT48_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g000864</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PT48"/>
    <dbReference type="OMA" id="VEYTICL"/>
    <dbReference type="OrthoDB" id="5230585at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012942">
        <property type="entry name" value="SRR1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42080">
        <property type="entry name" value="SRR1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42080:SF3">
        <property type="entry name" value="SRR1-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07985">
        <property type="entry name" value="SRR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SRR1-like" evidence="1">
        <location>
            <begin position="50"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM27055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="221" mass="25456" checksum="C8F453F8BB9543F1" modified="2014-04-16" version="1">MLTRASDTKLPISTEYIENPVPVDVTLRNILDIWKHTTEFQKLESLLKLVTPRKVTKIVGIASGSMEFGPDDEDCTYRSAMQHSMMITIKESIGKMTDKKIKCYAQDPRYTAVDTWALAEYNCEVLEDPKALLEIDDDCILFSCCPALPLKEITVDFARPAMLIWDRVVDEPNHGRHNPNSTRVQNMIRNEYVCHEFWDLREIGTAPFRSELVAYIRRQAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W6PTF8</accession>
    <name>W6PTF8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase/oxidase C-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PROQFM164_S01g000974</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PTF8"/>
    <dbReference type="STRING" id="1365484.W6PTF8"/>
    <dbReference type="OMA" id="EMEHIAF"/>
    <dbReference type="OrthoDB" id="10251155at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.600">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052904">
        <property type="entry name" value="Acyl-CoA_dehydrogenase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041504">
        <property type="entry name" value="AidB_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42707:SF2">
        <property type="entry name" value="ACD11 DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42707">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18158">
        <property type="entry name" value="AidB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0274">FAD</keyword>
    <keyword evidence="2 4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Adaptive response protein AidB N-terminal" evidence="8">
        <location>
            <begin position="22"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="7">
        <location>
            <begin position="186"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="6">
        <location>
            <begin position="313"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM27165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="636" mass="69863" checksum="7FFA3A07FFD30956" modified="2014-04-16" version="1">MSYSQPATADSGYITDPGPLENTYTSDPSLQRTLAWYLSSAVFQSVQPHLTQFGAEAISEQVREWSADAERNVPYVKSHNVWGKRYDHDRLVTTEGWKQLGKWGARNRIVSAGYDKGLGVDRRTVQYALTYLYSPSSGLYSCPISMTDGAAFILSSKIDTLPSTHPFHAAFQGLISEKDDHWTSGQWMTERAGGSDVQNTETWATYSPLATPSGSSGSDLLGDGDYLISGFKFFSSATDANLALLLAKTPSGKLSTFLAPLRRTVVDTNGVSKVVSNGVKIHRLKNKLGTKELPTAELELKDMRAHLLGELDQGIVTIAPLLNVTRLHTFVGSLAGWRRAMSITKSFAKARTTVGEPLWLIPMHLRLLADLEVKHRGAMNLAWLTVALFGIVEDQKPSSNKLAHLPQPGKEAEVVFRTLTATAKAVISKMATTGIQECQESMGGVGYMDEADEPEFNISRIMRNNAVNSIWEGTTNVLASEFVRFLIKNDNLKIFGTWLRRTLALIQSANLQNALTAAWSALRARFTAQDPASTVADGRRFMFTLAWILSGALLALDAERDNDLVTTEIARRWILSAEGGVGEQVFHDIVIVRSTASTISEGEEHLQWDCRIAWGVDLPANRASGHRSLQKASSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W6PU33</accession>
    <name>W6PU33_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FAD/NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PROQFM164_S01g001196</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PU33"/>
    <dbReference type="STRING" id="1365484.W6PU33"/>
    <dbReference type="OMA" id="HFTTGEP"/>
    <dbReference type="OrthoDB" id="4570620at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097237">
        <property type="term" value="P:cellular response to toxic substance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050097">
        <property type="entry name" value="Ferredoxin-NADP_redctase_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48105">
        <property type="entry name" value="THIOREDOXIN REDUCTASE 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00469">
        <property type="entry name" value="PNDRDTASEII"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004881063" description="FAD/NAD(P)-binding domain-containing protein" evidence="4">
        <location>
            <begin position="22"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="5">
        <location>
            <begin position="29"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDM27385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="384" mass="41824" checksum="E4ADCFF549C1EA82" modified="2014-04-16" version="1">MVLIKATFASAFVSLVACATAVEVPKTDYDVIVVGGGPAGLSALSGVSRVRRTALLIDSQEYRNAPTREMHDVIGNDGTPPATFRGLARAQIEKYPTAHFTNETVDSIVPFPQGDFSAFTVTTKDKNYTARKIVLGTGVRDVLPATPGLQAGWGHGIFWCPWCDGYEHRDQPFGMIGDITDMLGNVLETHTLYSDIIAFVNGSQTADGEARATAKVEDWKEQLAAWNTTIDNRTISSIERLQDGGDGRGEDGEQFDKFRLHFTTGEPVERNALIVNFPTVQTSALPAKMHLTLVDNKINVTSAMRTSESGVFAIGDANSDGSTNVPHAMYTGKKAAVYLHVEMSREESESKVSKRTGLSHRELEEEAINAIGNNLDAEWKRAQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W6PUH6</accession>
    <name>W6PUH6_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RAM signalling pathway, SOG2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PROQFM164_S01g001674</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PUH6"/>
    <dbReference type="STRING" id="1365484.W6PUH6"/>
    <dbReference type="OMA" id="NVHRACQ"/>
    <dbReference type="OrthoDB" id="1394818at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055414">
        <property type="entry name" value="LRR_R13L4/SHOC2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019487">
        <property type="entry name" value="RAM_signalling_pathway_SOG2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF46">
        <property type="entry name" value="LEUCINE RICH REPEAT-CONTAINING DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23598">
        <property type="entry name" value="LRR_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10428">
        <property type="entry name" value="SOG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Disease resistance R13L4/SHOC-2-like LRR" evidence="4">
        <location>
            <begin position="152"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="272"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="415"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="620"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="910"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="57"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="322"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="377"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="466"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="669"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="684"/>
            <end position="696"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDM27863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="988" mass="109455" checksum="3B8F1268E3D67FF3" modified="2014-04-16" version="1">MTPTMTRPEDAIRGQRLNRGETDEDEMENGTPESGFLASSRDDSPYPDEGTALGDASESTSKQPTGSKTLSPEETIDLARRAVESGIQDTKRSLAGSEAVTDVVKPKLTIDLGHSHIARIPEPVVDLIKDEVERLSLSNNQLFHIPYRFAECSHLRYLNIRANNFREFPKGVYKLPLLEILDLSRNKIKELPNEISKLKSLRVLSVMQNRLIDLPAGLSEMHKLQIFKCVGNPLRKPLREILEETENETTQSGMTDNEKEVAATTKLKRFLMKTRQQTSTPEPEIIPDTGDGTFEAKPAPTPIPSKRNLSGRFPVIPSTGDSSASSSRSPSISRAPPIPLKSHYRMASGQQGATYHMPGLQRPGVAPYPGNERNRSNSEGIIQGSSVARSKRMGLISRKNTDLGTLDETLPYRNSHLRGLSHGSVLRPRQPTPPIATNDNTPPSPTSPRERRRPRDGWVNRMSSLPEHKGEHGSDEPIIKSAKVILFALAQVHSHIDTLINVIKHDDTRRHSLELVFYNASSHVDHLNDALEKATDTLCNDPESMSSVTETVKRECETCIAAYIHVGTQLRNNVTKIVSNGDPCYVRSLMLTMFGSLAELRNACAILKVPLQTINRHGSATRRLVGPSNPLPSVPDRSQLSLVTPTRDPGPPTRRLRSDTTIRHPQYPMTMTSNQTSISSPGFSTSYARSRSSSRSNMINTSVPHSLAIPRSGETFPPMPASGAPRFNTLTGLDENEEERIFEKIFHQLTATYHAAYGALPLARRQFIRCLEAAQHSRDSEGIQILWNNLIRRCQFCLEVSDALGQRLSTMKIKEPGGGLRNQREFWQLCKSFMQSFVDLVNEMRELRGMQLLPAEVVILLRPVQKASREAGRLIEVSPWAYLTDPDRHPPPSALYGPLLQASHLQHHQTSVSTSALTNNPSFQLNTMSPPQSVTVPATPLSAALGPAAQATVPSTPASAYSDRFFDGDVFQRADSLLSSNQAPFFRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W6PUS2</accession>
    <name>W6PUS2_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RNA polymerase II-associated, Paf1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PROQFM164_S01g001332</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PAF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PUS2"/>
    <dbReference type="STRING" id="1365484.W6PUS2"/>
    <dbReference type="OMA" id="GAYYYPI"/>
    <dbReference type="OrthoDB" id="10260285at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016593">
        <property type="term" value="C:Cdc73/Paf1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007133">
        <property type="entry name" value="RNA_pol_II-assoc_Paf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23188">
        <property type="entry name" value="RNA POLYMERASE II-ASSOCIATED FACTOR 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23188:SF12">
        <property type="entry name" value="RNA POLYMERASE II-ASSOCIATED FACTOR 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03985">
        <property type="entry name" value="Paf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="134"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="447"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="471"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDM27521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="486" mass="54317" checksum="742C27039ECBF666" modified="2014-04-16" version="1">MSSKSKEGQSSGGFHQEYIASLRYRNDLPPPDMPPKFLDIPHEGLNRFLTPGFASNLARREEPNIEVDAEGGMPIDLVGIPGLHLGDESAIMAPENPQPMDPADLPLLMTIEQLRNPAPRNTNVSFLRRTQHIGVDRSGGDGSRPAPIKTQPRIAKKGKPPVDDPKHVKKFIQKGFDIAYPKSKHVGEDTDSHIRGLPPTKAELDAWANPVHPDNPKLKPVGFFPVMPDLEGFPDPGGYLQFKFDKAPLTAVGGKRDKRMDVGILTPVAPEQRICQEHESKLNLHLTNPVLYAHPGPVPYDYQLFLPEKPQSVKNIDASMNLSNPNRDSEDLYTNESAEGTKFHRYDRIRTYATSAQVFNTDQKDIALTLFKPKDGDTRQLAAYYYPISGKARLKPERARTIAQAGLAPTSTQQEETEERIDQMQVVMRDPNEAEIYKRALTRLRVDPKFASNMPPEPVAQEEEQSLDNGETEKPADEDTRMSDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W6PUU2</accession>
    <name>W6PUU2_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="6">O-methyltransferase, caffeic acid-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PROQFM164_S01g001362</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PUU2"/>
    <dbReference type="STRING" id="1365484.W6PUU2"/>
    <dbReference type="OMA" id="TRACFDI"/>
    <dbReference type="OrthoDB" id="1535081at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="COMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712:SF1">
        <property type="entry name" value="HYPOTHETICAL O-METHYLTRANSFERASE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005739">
        <property type="entry name" value="O-mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="O-methyltransferase C-terminal" evidence="5">
        <location>
            <begin position="234"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR005739-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDM27551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="396" mass="44070" checksum="205C53AD0FE220D9" modified="2014-04-16" version="1">MTQDMDTSLSAQIAALADSAQTRGLDEQARSEALNAARRLVAALESPVERIIQDVVMHSPALMAIRMGVQLGIFTQISQKPEGGASSPEIAENSGASLVLVDQITRLLAATGYIKQDGVQHFKPSPLTMVMADPVMEATTRACFEIGNLCTSKAPEFFRKNNNQFPSSAKDTPFQLGFNTDMNYFEWLGHNPDLAKDFQQWMTLKQKTTLNWVDWFDIQRSIIDGSSGKPEDVLLVDVGGGEGHYLRQFREKFPETPGRLILQDLPQVVSTVENLPEGIELTPHDFFTPQLVKGARAYFMHWILHDWSDEHCRSILANIVDAMEPGYSRLIIHESILPDLHCDLPSACLSVMMMVQVAAFERSEKQWRDLLASVGLTKVTFYQPPGSGEGIVEAFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>W6PVB1</accession>
    <name>W6PVB1_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Acyl-CoA desaturase</fullName>
            <ecNumber evidence="16">1.14.19.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">OLE1</name>
        <name evidence="19" type="ORF">PROQFM164_S01g001989</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Stearoyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>octadecanoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z)-octadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:19721"/>
            <dbReference type="Rhea" id="RHEA-COMP:10438"/>
            <dbReference type="Rhea" id="RHEA-COMP:10439"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57387"/>
            <dbReference type="ChEBI" id="CHEBI:57394"/>
            <dbReference type="EC" id="1.14.19.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="16">Expected to bind 2 Fe(2+) ions per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the fatty acid desaturase type 1 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.19.1" evidence="16"/>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PVB1"/>
    <dbReference type="STRING" id="1365484.W6PVB1"/>
    <dbReference type="OMA" id="WAHKSYN"/>
    <dbReference type="OrthoDB" id="10260134at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004768">
        <property type="term" value="F:stearoyl-CoA 9-desaturase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006636">
        <property type="term" value="P:unsaturated fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03505">
        <property type="entry name" value="Delta9-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000004">
        <property type="entry name" value="Acyl-CoA desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009160">
        <property type="entry name" value="Acyl-CoA_deSatase_haem/ster-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015876">
        <property type="entry name" value="Acyl-CoA_DS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001522">
        <property type="entry name" value="FADS-1_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11351">
        <property type="entry name" value="ACYL-COA DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11351:SF31">
        <property type="entry name" value="DESATURASE 1, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000345">
        <property type="entry name" value="OLE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00075">
        <property type="entry name" value="FACDDSATRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00476">
        <property type="entry name" value="FATTY_ACID_DESATUR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 16" id="KW-0249">Electron transport</keyword>
    <keyword evidence="15 16" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="8 16" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5 16" id="KW-0349">Heme</keyword>
    <keyword evidence="12 16" id="KW-0408">Iron</keyword>
    <keyword evidence="4 16" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="13 16" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 16" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="180"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="18">
        <location>
            <begin position="330"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR000345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CDM28178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="455" mass="51933" checksum="1A9D713AF08EF657" modified="2014-04-16" version="1">MSSKLDASRPRAADTKKVHIADTQMTRQNWYKHVNWLNVTFIIGVPLTGCIQAFFVPLQLKTAIWAVIYYFFTGLGITAGYHRLWAHCSYSATLPLRIWLALVGGGAVEGSIRWWARDHRAHHRYTDTDKDPYSVRKGLLYSHLGWMVMKQNPKRIGRTDITDLNEDPVVVWQHRNYIKVVLTMGLIVPMLVAGLGWGDWYGGFVYAGILRIFFVQQATFCVNSLAHWLGDQPFDDRNSPRDHIITALVTLGEGYHNFHHEFPSDYRNAIEWHQYDPTKWTIWICKQLGLAYDLKQFRSNEIEKGRVQQLQKKIDQKRAKLDWGTPLDQLPVMEWEDYVEQTKNGRGLISIAGVVHDVTDFIKDHPGGKAMIKSGLGKDATAMFNGGVYYHSNGAHNLLSTMRVGVIRGGGEVEIWKRAQKENSEYVRDETGQRIIRAGQQVTKMPEPIPTADAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W6PW17</accession>
    <name>W6PW17_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Eukaryotic peptide chain release factor subunit 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">SU2</name>
        <name evidence="7" type="ORF">PROQFM164_S01g001916</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic release factor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PW17"/>
    <dbReference type="STRING" id="1365484.W6PW17"/>
    <dbReference type="OMA" id="GPGTEKM"/>
    <dbReference type="OrthoDB" id="10254527at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018444">
        <property type="term" value="C:translation release factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003747">
        <property type="term" value="F:translation release factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.60:FF:000001">
        <property type="entry name" value="Eukaryotic peptide chain release factor subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.960.10:FF:000001">
        <property type="entry name" value="Eukaryotic peptide chain release factor subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000006">
        <property type="entry name" value="Peptide chain release factor subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.960.10">
        <property type="entry name" value="eRF1 domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.60">
        <property type="entry name" value="eRF1 domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042226">
        <property type="entry name" value="eFR1_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024049">
        <property type="entry name" value="eRF1_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005141">
        <property type="entry name" value="eRF1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005142">
        <property type="entry name" value="eRF1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005140">
        <property type="entry name" value="eRF1_Pelota-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004403">
        <property type="entry name" value="Peptide_chain-rel_eRF1/aRF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03676">
        <property type="entry name" value="aRF1_eRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10113">
        <property type="entry name" value="PEPTIDE CHAIN RELEASE FACTOR SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03463">
        <property type="entry name" value="eRF1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03464">
        <property type="entry name" value="eRF1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03465">
        <property type="entry name" value="eRF1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01194">
        <property type="entry name" value="eRF1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55481">
        <property type="entry name" value="N-terminal domain of eukaryotic peptide chain release factor subunit 1, ERF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="eRF1/Pelota-like N-terminal" evidence="6">
        <location>
            <begin position="8"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="427"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="427"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="452"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM28105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="531" mass="59060" checksum="319C6DF4169BE336" modified="2014-04-16" version="1">MSAPPPNEAEKNIEIWKVKKLIKRLEAARGNGTSMISLIIPPKDQVSRAAKMLAEEYGTASNIKSRVNRLSVLSAITSTQQRLKLYNKVPPNGLVVYCGEIITSEGKERKINIDFEPFKPINTSLYLCDNKFHTEALSELLEADQKFGFIVMDGNGTLFGTLSGNTREILQRLTVDLPKKHGRGGQSALRFSRLREEKRHNYVRKIAELAVQNYITNDKPNVAGIVLAGSADFKNDLNQSDLFDGRLQSKVIKIVDVSYGGENGFNQAIELAGETLSNVKFVQEKKLINQYFQEISQDTGKVCYGIEDTLKAMELGAAEILIVHENLEITRWVMKNSAGAQVIVHTTKAQEANKDIFQDKETGMDMEVVESGSFLEWLAEAYKDFGANLEFVSDRSGEGNQFVKGFGGIGAILRYKVNFEQLADHSDDDEFYDESEDERPEAPAASLLTARPVDHTGGSRDGTKASVKDNQKRPGPRPVKLLRVSSKLQDTHTELASVSEMKKRFKLQFERLGAVICNVWSSTAACTAYSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W6PXK5</accession>
    <name>W6PXK5_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">MICOS complex subunit MIC60</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Mitofilin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">fcj1</name>
        <name evidence="16" type="ORF">PROQFM164_S01g000498</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Plays a role in keeping cristae membranes connected to the inner boundary membrane. Also promotes protein import via the mitochondrial intermembrane space assembly (MIA) pathway.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 13">Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Mitochondrion inner membrane</location>
            <topology evidence="1 13">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the MICOS complex subunit Mic60 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PXK5"/>
    <dbReference type="STRING" id="1365484.W6PXK5"/>
    <dbReference type="OMA" id="RLDHQMQ"/>
    <dbReference type="OrthoDB" id="10261039at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061617">
        <property type="term" value="C:MICOS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042407">
        <property type="term" value="P:cristae formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019133">
        <property type="entry name" value="MIC60"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15415:SF7">
        <property type="entry name" value="MICOS COMPLEX SUBUNIT MIC60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15415">
        <property type="entry name" value="MITOFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09731">
        <property type="entry name" value="Mitofilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 13" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="40"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="190"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="295"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="44"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="190"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU363000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CDM26689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="624" mass="69451" checksum="0DAD7808E4915AAC" modified="2014-04-16" version="1">MLRSSIAPGRQLLSNPVRQRIPSQWLSRAGASNRLVGQRFFADSKPPSTGGPTPVSPSSESSIPPKTISQAAEQESKLPPSPPAAAPRKSGRFRRFLIYLILTSGFAYGGSIFLALKSDNFHDFFTEYIPYGEECVLYFEERDFYRRFPNALRHQNRLPAVPREEEKPITIPGKSGLSWKIAEEVKAEVDSKKAAETHDGQTKSTAKPEDRTAVVKKAKEDASKPSSKDTKPDSEAKNPVSLDQPRQPAVSASTIELVKLQDGDDAVVQHLVKTFNDIVTVISADENSGKYSAPVAKAKGELEKIAEKIAGIRSEARNTAQEELNKLHATFDDSARELMRQFEEVRSTDLASFREEFEAEREKLAQAYQHKVKTELRHAQELAEQRLQNELVEQAIELNRKYVHEVQSLVEREREGRLSKLTELTADINELEKLTAGWSDVIDTNLKTQQLQVALDAVRTVVERAETPRPFVRELVAVKELAAGDAVVEAAIASINPTAYQRGIPSTTQIFERFRRVASEVRKASLLPEDAGVASHAASLVLSKVMFKKDALSEGDDVESVLVRTENLLQQGDVDAAAREMNTLQGWAKILSKDWLGDVRKVLEVRQALEVIEAEARLQCLRVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W6PXL2</accession>
    <name>W6PXL2_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WLM</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S01g002337</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PXL2"/>
    <dbReference type="STRING" id="1365484.W6PXL2"/>
    <dbReference type="OMA" id="GMQKHPF"/>
    <dbReference type="OrthoDB" id="49605at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013536">
        <property type="entry name" value="WLM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47795:SF1">
        <property type="entry name" value="DNA-DEPENDENT METALLOPROTEASE WSS1 HOMOLOG 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47795">
        <property type="entry name" value="UBIQUITIN AND WLM DOMAIN-CONTAINING METALLOPROTEASE SPCC1442.07C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08325">
        <property type="entry name" value="WLM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51397">
        <property type="entry name" value="WLM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WLM" evidence="2">
        <location>
            <begin position="128"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="325"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM28526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="345" mass="38319" checksum="D24719CA67F7370F" modified="2014-04-16" version="1">MDSPKELTVHHHGTAHIIQVPASATLQDLSSEIERVLNIPVDNQKLLIAPKPGMQKAPFPPTLLDAILQPSSPKFKITLLGTPAKAIADLHEQSASEQRRQELRASALSAARRNKQTPSSRSGGIHTISSSSNNYTFHRLLPLSYLPNPDRSLDFLKRLRDDPGIRAAMTKHKFSVPLLTEMNPAEHTTSESRTLGLNRNKGEVIELRLRTDAYDGYRDYRTIRKTLCHELAHCVFGPHDRDFWDLTSQIEKEVDRADWKSGGNQLSGQEFYNPGDWDSAQDGEEFVDECGWTGGEFVLGGLQGDSTGGRNAASGGTLSRREIMARAAEERMKRESQAGKQDDAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W6PY40</accession>
    <name>W6PY40_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PROQFM164_S01g000703</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM164</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PY40"/>
    <dbReference type="STRING" id="1365484.W6PY40"/>
    <dbReference type="OMA" id="DFYDIGY"/>
    <dbReference type="OrthoDB" id="2094832at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051654">
        <property type="entry name" value="Meroterpenoid_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35897">
        <property type="entry name" value="METHYLTRANSFERASE AUSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35897:SF1">
        <property type="entry name" value="METHYLTRANSFERASE AUSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDM26894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="286" mass="32955" checksum="7275420B99A5C715" modified="2014-04-16" version="1">MAKAESDLRSILDGGFDPHKFAWYEPELIEVPEPAKSLLEKYSKIPPGHEVEHVKKVRDRAFAVFPYPCIGSFRFLDLSIPQSPLYPEILDRLKSGQKLLDVGCAVGQELRQLVFDGVASENLYASDLRQDFYDIGYELFNDRDHLKAQFIVADIFDDNSDLVKQLTHKIDIVNAASFFHLFNWDQQILVAKRLVGLLQDKPGSLLIGRQIGLVNPPPPEDKEASGEHYRHDPSTWKKFWEQVGTETGTRWEVETRMEKWAGADKMMKDYHEGMDTFKLRFSVRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W6PY65</accession>
    <name>W6PY65_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g000728</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PY65"/>
    <dbReference type="STRING" id="1365484.W6PY65"/>
    <dbReference type="OrthoDB" id="4685598at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM26919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="111" mass="12114" checksum="33A3882BBD256F29" modified="2014-04-16" version="1">MCSDLNAECVYREPGIKLDTGGKLILDHLARIETLLHSNLQNQEPHLAPSATSPATSNDTNLGSDDPSTRTSSRGLPVHRRLSAVGLSPRVRLPTLHPLHLPLIRDLVSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W6PYJ4</accession>
    <name>W6PYJ4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S01g002906</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PYJ4"/>
    <dbReference type="STRING" id="1365484.W6PYJ4"/>
    <dbReference type="OMA" id="YVRQVDI"/>
    <dbReference type="OrthoDB" id="4505556at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM29095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="326" mass="36809" checksum="CB4F8BB08CC99AF2" modified="2014-04-16" version="1">MYLPAEIIDLITFYVEIGTSQSSSKTSAPREFRIMNNYNRRNLAKLRLVNKSLCHSASARLFRHIIALAGSLYHTRHFPSLGKLVSLSNSPYAHYVRQVDIGYGSFPCSIREVTSYTEDLAGLLSLCLRQFPNLKALDFRGPSLTLLPHDKMKASIDSMLMSLCYVPLPNLTELELQLPMTNDLAPLFAENISTLRIPIEQTLSRLHHLRLQVYAQTNQQSCAAHLLSIAELSTSLTSLSLSSTNYLSIDRLKLGSTVRLQFLSLREVKISSQNLVNIIEQCSESMKYIELRHVKLETGTWREILSAMDSLPHLYDFDISVGETPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W6PYP3</accession>
    <name>W6PYP3_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF1996 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S01g003200</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PYP3"/>
    <dbReference type="STRING" id="1365484.W6PYP3"/>
    <dbReference type="OMA" id="ANCKDGI"/>
    <dbReference type="OrthoDB" id="74764at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018535">
        <property type="entry name" value="DUF1996"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662:SF7">
        <property type="entry name" value="DUF1996 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09362">
        <property type="entry name" value="DUF1996"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004881679" description="DUF1996 domain-containing protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1996" evidence="2">
        <location>
            <begin position="39"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM29388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="513" mass="55672" checksum="7C021F4F95E8330B" modified="2014-04-16" version="1">MQDIRMASIVMACFALFPSLTNAFWRLPCRGRTGLARLDPLVDPGTVSSHAHAVHGGGSFGMSSDEASLLESDCTSCAVTQDKSAYWVPALYFMHTNGSAEVVDEVGGMLAYYLLYGENVTAFPSNFRMLAGDPYQRNFTWPVPDPPKSDWSGAQASQAALRQKALGFNCLDYSATAEASLYRHFLPNKTYLDEHCTDGVRFELMFPSCWNGKDVDSTDHKSHVAYPSLVMDGTCPEGFETRLVSLFYETIWNTYAFKDVDGYFALANGDPTGYGYHGDFMQAWDDGILQQAIDTCTSESGIVTDCEIFDVQTEDEQRQCQFPVPSVIKNENCELHEDGLPGGMAIQWGPEYATMKSAATTTTSSVVSVPTISIPTSSLPTVSVGGISIDPNTLLENLHVTSAAEATTSFTSTSTPSPTPTAITSTIIDPITEEIIYLERDVYVICDGNGVVYSTSTGAVRTVSTSLTTIVETSTAVSYAKKDTVPEAVEPVQAAGHARRHLHHRHGHGHNSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W6PZ60</accession>
    <name>W6PZ60_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g003365</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PZ60"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM29553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="41" mass="4244" checksum="9501E5E9825C5A77" modified="2014-04-16" version="1">MLLDETALNRSLSATTRVSSTTSSSYCAGVAFPNNNPTAPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>W6PZD0</accession>
    <name>W6PZD0_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ferric-chelate reductase (NADPH)</fullName>
            <ecNumber evidence="3">1.16.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PROQFM164_S01g002897</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>2 a Fe(II)-siderophore + NADP(+) + H(+) = 2 a Fe(III)-siderophore + NADPH</text>
            <dbReference type="Rhea" id="RHEA:28795"/>
            <dbReference type="Rhea" id="RHEA-COMP:11342"/>
            <dbReference type="Rhea" id="RHEA-COMP:11344"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.16.1.9"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ferric reductase (FRE) family.</text>
    </comment>
    <dbReference type="EC" id="1.16.1.9" evidence="3"/>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PZD0"/>
    <dbReference type="STRING" id="1365484.W6PZD0"/>
    <dbReference type="OMA" id="KQDTMEL"/>
    <dbReference type="OrthoDB" id="4494341at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052851">
        <property type="term" value="F:ferric-chelate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000071">
        <property type="entry name" value="Cell surface metalloreductase (FreA), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051410">
        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361:SF26">
        <property type="entry name" value="FAD-BINDING 8 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="215"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="14">
        <location>
            <begin position="249"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CDM29086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="531" mass="59289" checksum="D76B84853690DD48" modified="2014-04-16" version="1">MDILTIYAIAVGGIFTSLIIIRVLNVFAPWGNAMNVFIYQHLAYPYVLRRHSRLGPWTRAGVSLHLIYLAVNLLLLFFNHISMAATGRRAGTLSLLNMIFLLASWHLSNLADIFGISLRIYRRMHRAAGWMVVALVLFHVFAMLQGKIQEDQGMNTGRLSAIIGAGSLCSLVILSLPFCRKFSYELFLRLHQALVVASVYGIWRHLPGETYSPRFYLYVALGILGCTSLSHLILLLYRNGLFSGNGCPRAIAICHTNERDAENAGQHVRTTPIRVRLILPRPVKAMAGQYINLWLPSLSLWSWAQTHPFMITSWSRADQGVLDLLVEPRGGLTKALVRQAHAAAKDNFSSLALYSGPHGISESVDKYESVLLVASGAGIAAIIPYAKKLIHGYNTCTSHVRRVHLIWQVESLDVAISMQGLLNGLLKDDVLDDGYILAISVYVGRGPLTHGKLPFGKHERAFLYQGAPDYSIIIPTEVSGEKIERLPNIRDERGQMLLIASTSGHLRDTLRHIVQGYLHQRLQMIELEYQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>W6PZQ1</accession>
    <name>W6PZQ1_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosome assembly protein 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Notchless protein homolog 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Ribosome biogenesis factor RSA4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">RSA4</name>
        <name evidence="12" type="ORF">PROQFM164_S01g001245</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the NLE1/RSA4 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PZQ1"/>
    <dbReference type="STRING" id="1365484.W6PZQ1"/>
    <dbReference type="OMA" id="AWEPYHR"/>
    <dbReference type="OrthoDB" id="10267436at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000092">
        <property type="entry name" value="notchless protein homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012972">
        <property type="entry name" value="NLE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001632">
        <property type="entry name" value="WD40_G-protein_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848:SF0">
        <property type="entry name" value="NOTCHLESS PROTEIN HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08154">
        <property type="entry name" value="NLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00319">
        <property type="entry name" value="GPROTEINB"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 9" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="NLE" evidence="11">
        <location>
            <begin position="36"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="140"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="183"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="226"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="274"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="397"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="439"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="481"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00061016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00068030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00077034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00080836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDM27434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="514" mass="56357" checksum="BF742925A8691302" modified="2014-04-16" version="1">MSTLYPPPSKRQKLVQADKAREQQEIESIPSDLGSVRVQFFDQATGQPTGPAVSVPVADANVKNLETLLNTLQGNEDDGRVPYRFAYHSEKEEQTIDILRDVYHSLLQTGIKSTEDTVSLFYTPQAVFRVKAVSRCAASIAGHGEAILATSFSPVSSSTMVSGSGDSTARVWDCDTGTPKHTLKGHTSWVLAVAYSPNGAMIATGSMDNTVRFWDAKQGTALGAGLKGHAKWITNLAWEPYHVQESGRPRLASASKDSTVRVWDVVSRVTDHVLTGHKSSVTCVRWGGTGKIYTASHDKTIKIWNPKDGTLLQTLAAHAHRVNHLALSTDFALRTAYHDHTGKVPVTEAEKVAAARKKFEEAATVNNTIVERLVSASDDFTMYLWEPSTSSKPVARMLGHQKEVNHVTFSPDMAYIASAGFDNHVKLWNGRDGKFITTFRGHVGAVYQCCFSADSRMLVSSSKDTTLKIWDLRTGKLKMDLPGHKDEVFAVDWSPDGQKIASGGKDKAIKIWRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q062</accession>
    <name>W6Q062_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S01g001415</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q062"/>
    <dbReference type="STRING" id="1365484.W6Q062"/>
    <dbReference type="OrthoDB" id="1600564at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001087">
        <property type="entry name" value="GDSL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00657">
        <property type="entry name" value="Lipase_GDSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004879506" evidence="2">
        <location>
            <begin position="19"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM27604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="212" mass="23298" checksum="420577D93B99F324" modified="2014-04-16" version="1">MIILTICVLAIAFGTIFARASPLSRPAKLNWSSTKALIAFGDSYTYVQGTIGHQNFSFIGDQFNLAYDAEALLSNKIVQNQTATAEGGPNWVEYLTNCGIHQGLTSPQDCKKQLWDFAFAGADISTEYTPPHHNFTVSLLDQINQFKQYGHPALLNSLPSFTQDKTLVAIWIGINDINDSAKNYLFMNLPPLDRTPGNQATKDPSPNSGRVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q1J0</accession>
    <name>W6Q1J0_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">uracil phosphoribosyltransferase</fullName>
            <ecNumber evidence="4">2.4.2.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PROQFM164_S01g001895</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM164</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uracil: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UPRTase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.9" evidence="4"/>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q1J0"/>
    <dbReference type="STRING" id="1365484.W6Q1J0"/>
    <dbReference type="OMA" id="KHKIGLM"/>
    <dbReference type="OrthoDB" id="106623at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004845">
        <property type="term" value="F:uracil phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008655">
        <property type="term" value="P:pyrimidine-containing compound salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000023">
        <property type="entry name" value="Probable uracil phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001097">
        <property type="entry name" value="PRK00129.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14681">
        <property type="entry name" value="UPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="11">
        <location>
            <begin position="43"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF14681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDM28084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="246" mass="27408" checksum="60EE634D78EDFE66" modified="2014-04-16" version="1">MASKPESGPSPAQGVGPLYRPDGEKPTATVSKEVSYENVHVLPQTPQLIALLTMIRDKRTCRADFIFYSNRIIRLLVEEGLNHLPVVEQSITTPVGRSYLGVKFEGKICGVSIMRAGEAMEQGLRDCCRSVRIGKILIQRDEETCMPKLFYDKLPTDIADRWVLLLDPMFATGGSATLAVETLIERGVPEHRILFLNLIASPSGVAEFAERFPKLRVVTSFIDQGLDEKKYIIPGLGDFGDRYYSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q1P5</accession>
    <name>W6Q1P5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Quinate repressor protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">qutR</name>
        <name evidence="11" type="ORF">PROQFM164_S02g000612</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the 2nd section; belongs to the type-I 3-dehydroquinase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the shikimate kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q1P5"/>
    <dbReference type="STRING" id="1365484.W6Q1P5"/>
    <dbReference type="OMA" id="AVYSMIH"/>
    <dbReference type="OrthoDB" id="4415835at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003855">
        <property type="term" value="F:3-dehydroquinate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003866">
        <property type="term" value="F:3-phosphoshikimate 1-carboxyvinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004764">
        <property type="term" value="F:shikimate 3-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00502">
        <property type="entry name" value="DHQase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01065">
        <property type="entry name" value="NAD_bind_Shikimate_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10860:FF:000019">
        <property type="entry name" value="Quinate pathway repressor protein QutR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002254">
        <property type="entry name" value="Quinate pathway repressor protein QutR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000386">
        <property type="entry name" value="Quinate repressor protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10860">
        <property type="entry name" value="Leucine Dehydrogenase, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001381">
        <property type="entry name" value="DHquinase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041121">
        <property type="entry name" value="SDH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031322">
        <property type="entry name" value="Shikimate/glucono_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013708">
        <property type="entry name" value="Shikimate_DH-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006151">
        <property type="entry name" value="Shikm_DH/Glu-tRNA_Rdtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21090">
        <property type="entry name" value="AROM/DEHYDROQUINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21090:SF27">
        <property type="entry name" value="QUINATE REPRESSOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01487">
        <property type="entry name" value="DHquinase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18317">
        <property type="entry name" value="SDH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01488">
        <property type="entry name" value="Shikimate_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08501">
        <property type="entry name" value="Shikimate_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01202">
        <property type="entry name" value="SKI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01100">
        <property type="entry name" value="SHIKIMTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0672">Quinate metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Shikimate dehydrogenase substrate binding N-terminal" evidence="9">
        <location>
            <begin position="560"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="domain" description="Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase" evidence="8">
        <location>
            <begin position="700"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="domain" description="SDH C-terminal" evidence="10">
        <location>
            <begin position="842"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF18317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDM30463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="899" mass="99453" checksum="DC9B2E61B7DE0FB4" modified="2014-04-16" version="1">MSMLVRPPKRKLHEVETLDDGPRKYSPGVVPPHTILPSSQPPSRPSSERTQASGYSHPPSLKELNSNRGSPILFEQGHLQTPRTFSPKASVVLIGIRGTGKSSLAVILAATSGRRLIDADRYFHQTVGCSRAEFKKENDGSVYRLQEARVFESMLADNQDGCVIACGAGSMERNGQRLLREYAQTHPVIHVVRDAESIQSYLKAWDTQKVRHFLELSGPIYRGCSNLEFFNLSEARSDSDVASPTYRTEPRSHTPIPFLTLKRVQRDFLRFIAFITGDIAELNSQHASFPLSLLPVESRMYTSAVSVPFSKICEKGMDIEQLEFTADAFELAVDVTDSSGQPGLSSSLADSISQAVATIRRNIIVPLIYHVESYTTPTGSLSPNQVPLRCTDETYLNLVRHGLRLSTGFLTVDLTRDDNIISQIISSSGRTRIIGHFEAFHPLPGGWDGDEYMEVYERAKSLGCDIVRLCQPAETPEDNLAVQRFRHRIQSLPVAGISLIAYNTGPLGRMSRCFNPILSPVTHPSLVTELPTHLRSYITAREVQKALYSSFALDPMQFFVFGANTTYSMSPAMHNTAFKICGLPHNYSIHQSPTLRGLNELVENQYFGGSSVSLPYKTECIPLLHSMSAHARAIGAVNTLIPIRNLDDLDDNRLQESSVFLQKSRAGPIKGLHGDNTDWIGICNCIRRGLSPANAIRSSSTGLVIGSGGMARAAIYSMIHLGVQNIFVYNRTIANAERLAHHYNRQDLHSKEASGSGRPTVRIIASLSDPWPADFKQPTIVVSGIPAHSIGGELAPNFHMPAQWLESPTGGVVVDLAYKPLNTPLMKQTRALSHRGWVALDGLDVLPEQGFAQFELFTGRRAPRRVMRSIVLQEYKDDEGNNDHEAIRDRLQQMDGQPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q2C5</accession>
    <name>W6Q2C5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pleckstrin homology-like domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S02g000843</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q2C5"/>
    <dbReference type="STRING" id="1365484.W6Q2C5"/>
    <dbReference type="OMA" id="NFKDSFM"/>
    <dbReference type="OrthoDB" id="2357150at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006913">
        <property type="term" value="P:nucleocytoplasmic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13179">
        <property type="entry name" value="RanBD_RanBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000254">
        <property type="entry name" value="Ran-specific GTPase-activating protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000156">
        <property type="entry name" value="Ran_bind_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045255">
        <property type="entry name" value="RanBP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045256">
        <property type="entry name" value="RanBP1_RanBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23138:SF87">
        <property type="entry name" value="E3 SUMO-PROTEIN LIGASE RANBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23138">
        <property type="entry name" value="RAN BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00638">
        <property type="entry name" value="Ran_BP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00160">
        <property type="entry name" value="RanBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50196">
        <property type="entry name" value="RANBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RanBD1" evidence="2">
        <location>
            <begin position="108"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="14"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="34"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM30693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="251" mass="27926" checksum="5F448682B829BC63" modified="2014-04-16" version="1">MSDITETKPDPAISASETTEQTTTATGEGEKSTTETVAETVATTAEKAADTAKDATVKTSDSMFSMFGGGPKKEKKEEAEEPTDEPSGSSKAQKANDEDEVEESVDVHFEPVIRLTEKVETKTNEELEEQTFKMRAKLFKFDRDSKEWKERGTGDVRLLKHKENQKTRLVMRRDKTLKVCANHYIVPDMKLSANVGSDRSWVWNAAADVSEGEPEAQTLAIRFANSENANAFKDAFETAQVENEKLFNAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q2I0</accession>
    <name>W6Q2I0_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycoside hydrolase, family 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S02g000674</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q2I0"/>
    <dbReference type="OMA" id="TPWNGDY"/>
    <dbReference type="OrthoDB" id="2848340at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004560">
        <property type="term" value="F:alpha-L-fucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.10:FF:000028">
        <property type="entry name" value="Alpha-L-fucosidase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049053">
        <property type="entry name" value="AFCA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016518">
        <property type="entry name" value="Alpha-L-fucosidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054363">
        <property type="entry name" value="GH95_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027414">
        <property type="entry name" value="GH95_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31084">
        <property type="entry name" value="ALPHA-L-FUCOSIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31084:SF18">
        <property type="entry name" value="GLYCOSYL HYDROLASE FAMILY 95 N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14498">
        <property type="entry name" value="Glyco_hyd_65N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21307">
        <property type="entry name" value="Glyco_hydro_95_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22124">
        <property type="entry name" value="Glyco_hydro_95_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007663">
        <property type="entry name" value="UCP007663"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 95 N-terminal" evidence="1">
        <location>
            <begin position="4"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 95 catalytic" evidence="3">
        <location>
            <begin position="263"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha fucosidase A-like C-terminal" evidence="2">
        <location>
            <begin position="665"/>
            <end position="735"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM30525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="739" mass="83032" checksum="978AF7E4CCA9B150" modified="2014-04-16" version="1">MSELWYQQPAEDWNSALPVGNGRLGAMVYGRTDTEMLQLNEDSVWYGGPQDRNPQDALKYLPRLREAIRAENHVEAEKIAKLAFFANPISQRNYEPLGNLFLDLGHDPSRVTGYRRSLDLESATAHVGYEYQGVRFKREVFASYPDDVLAIRLRSSSKAEFVVRLTRMSDLEYETNEWLDDVSASRDSITMHVTPGGRNSNRACCVVSVRCYGDESTITKIGNNLVVNSGDTLLVIAAQTTFRHKDIDQRTKQDAENALGLSLEDLRSRHVSDYQSLYDRMGLQLGPSSPEVPTDQRLKYSRDPGLIALYHNYNRYLLISCSRDVHKSLPANLQGIWNPSFHPAWGSRFTTNVNLQMNYWSANVCNLSECELPLFQLLERMVEPGKATARIMYGCRGWTAHSNTDIWADTAPVDRWMPASIWPLGGAWLCYHIWDHFQYTCDEEFLRRMFPTLRGCVEFLLDFLIQDTNGVYLVTSPSASPENSFYDSKGEKGTLCEGSTIDIQIIAAILDAFESCAKRLGLEDALLPSVQATKSRLPPMKISPAGYLQEWAADYAEVESGHRHMSHLWALYPGNAITPSRTPQLAEACGEVIRRRAEHGGGHTGWSRAWLLNLHARLLEAEECSGHLDLLLSRSTWPNLLDSHPPFQIDGNFGGGAGIIEMLVQSHEPGVIRILPACPRGWTGSIRGVRARGGFELKFNFKNGRVVGEVTIYSERGETVVVHFNELQVEITGGGEHKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q2P1</accession>
    <name>W6Q2P1_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S02g000958</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the OPI10 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q2P1"/>
    <dbReference type="STRING" id="1365484.W6Q2P1"/>
    <dbReference type="OMA" id="WWAKFER"/>
    <dbReference type="OrthoDB" id="10248398at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061608">
        <property type="term" value="F:nuclear import signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048364">
        <property type="entry name" value="Hikeshi-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008493">
        <property type="entry name" value="Hikeshi-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031318">
        <property type="entry name" value="OPI10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12925">
        <property type="entry name" value="HIKESHI FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12925:SF0">
        <property type="entry name" value="PROTEIN HIKESHI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21057">
        <property type="entry name" value="Hikeshi-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05603">
        <property type="entry name" value="Hikeshi-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hikeshi-like N-terminal" evidence="2">
        <location>
            <begin position="5"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="Hikeshi-like C-terminal" evidence="3">
        <location>
            <begin position="164"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM30808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="224" mass="24279" checksum="E9173113FB030649" modified="2014-04-16" version="1">MFSVVVPGRPCLTDIIAVDSHLNGQATKFAFTIPISASLSDIVVFMLPGATLPPNTGAAIYAQLPDPTTGEPSDFRFVGALANEKPSGIFTVRPQGRAPRRSEAEEEDDMLDEDTAVTGVMTLGISIEEAQNIAPQLASLESERPSGRTSMALVSQSPAQKQISTKLLAQRIIGNAFNFLASFAENENGQDVVPLKSFQNWWAKFERRIEADPSFLEREDPNAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q2S3</accession>
    <name>W6Q2S3_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Apc13p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PROQFM164_S02g000780</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the APC13 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q2S3"/>
    <dbReference type="OMA" id="NIHMHHP"/>
    <dbReference type="OrthoDB" id="2351920at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008401">
        <property type="entry name" value="Apc13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28526">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28526:SF1">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05839">
        <property type="entry name" value="Apc13p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="20"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="141"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="27"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="41"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="145"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM30630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="187" mass="19467" checksum="9121B41AE1064904" modified="2014-04-16" version="1">MSKDSSASYLHMHQPRLADLFEEFTRPHTSTATNSTTDPHNANSASAANREAASTNAIPYGSTSPSTIPSFLPIEDIYVAPQYQPPNPEDEDDVVPDQHAAFGITRAMERRREAVWRDLGLEALVNGEGYGPDAGPLTGAGGAGAATSGPGATLRGSGGGAAAAGAPVIRVRDSGRRMGGRRVIGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q2Y2</accession>
    <name>W6Q2Y2_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA repair protein RAD51 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">rhp51</name>
        <name evidence="11" type="ORF">PROQFM164_S02g000485</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required both for recombination and for the repair of DNA damage caused by X-rays.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the RecA family. RAD51 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q2Y2"/>
    <dbReference type="STRING" id="1365484.W6Q2Y2"/>
    <dbReference type="OMA" id="RAYNSNH"/>
    <dbReference type="OrthoDB" id="10251254at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000794">
        <property type="term" value="C:condensed nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070192">
        <property type="term" value="P:chromosome organization involved in meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000730">
        <property type="term" value="P:DNA recombinase assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042148">
        <property type="term" value="P:DNA strand invasion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006312">
        <property type="term" value="P:mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990426">
        <property type="term" value="P:mitotic recombination-dependent replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19513">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000008">
        <property type="entry name" value="DNA repair protein RAD51 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000092">
        <property type="entry name" value="DNA repair protein Rad51 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011941">
        <property type="entry name" value="DNA_recomb/repair_Rad51"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016467">
        <property type="entry name" value="DNA_recomb/repair_RecA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010995">
        <property type="entry name" value="DNA_repair_Rad51/TF_NusA_a-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013632">
        <property type="entry name" value="Rad51_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020587">
        <property type="entry name" value="RecA_monomer-monomer_interface"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003301">
        <property type="entry name" value="PRK04301.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02239">
        <property type="entry name" value="recomb_RAD51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22942:SF39">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD51 HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22942">
        <property type="entry name" value="RECA/RAD51/RADA DNA STRAND-PAIRING FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14520">
        <property type="entry name" value="HHH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08423">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005856">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47794">
        <property type="entry name" value="Rad51 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50163">
        <property type="entry name" value="RECA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecA family profile 1" evidence="9">
        <location>
            <begin position="95"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="RecA family profile 2" evidence="10">
        <location>
            <begin position="275"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDM30336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="344" mass="37210" checksum="0466573D94A0121B" modified="2014-04-16" version="1">MEGEEQLEDSGLPGPGAPTPLSALDGVSGLTARDIKLFLDAGYNTVESIAYTPKRLLEQIKGISEQKATKILVEASKLVPMGFTTATEMHARRSELISITTGSKRLDTLLGGGFETGSITEIFGEFRTGKSQICHTLAVTCQLPFDMGGGEGKCLYIDTEGTFRPVRCLAVAERYGLVGDEVLDNVAYARAYNSDHQLSLLNQASQMMCETRFSLLVVDSATSLYRTDFNGRGELASRQSHLAKFMRTLQRLADEFGIAVVITNQVVAQVDGGPSAMFNPDPKKPIGGNIIAHASTTRLSLKKGRGETRICKIYDSPCLPESDCLFAINDNGIGDPSEKDLEDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q328</accession>
    <name>W6Q328_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S02g001138</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q328"/>
    <dbReference type="STRING" id="1365484.W6Q328"/>
    <dbReference type="OMA" id="MGYDQIN"/>
    <dbReference type="OrthoDB" id="10266980at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016814">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052349">
        <property type="entry name" value="Metallo-hydrolase_Enzymes"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32027">
        <property type="entry name" value="CYTOSINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32027:SF0">
        <property type="entry name" value="CYTOSINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="1">
        <location>
            <begin position="59"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM30988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="468" mass="51942" checksum="1867A4FCE22C4764" modified="2014-04-16" version="1">MSPPRLTSQINYIRGVRLAGEPSTWDIQIGYPRDSLRGTVTSVTPHESSTKDDFESPLALPALVHPHIHLNKAFIHSAPEYAPFLPTAGTFQEALSSTTKAKQQFSHSDIIRRGEWLLAESVASGVTAMRAFVEVDHTVQLICLEAAVALKNQWKDSCDIQIVCFAQDPIFSSEYGEQNMEFLETALHKYSQIDVIGTTPYVESSPEAAKQNIEWAIDRALKLNKHVDFHLDYNLDSKKEALVWHVLQTLKQRSWTIHSTDKRVMLGHCTRLTLLTETEWVRLATEIHENELSVSFVGLPTSDMYMASPPRTSGDCKPPQDRPRGTLQVLEMIRKYDLDAVIGVNNVGNSFTPWGLPDPLSLACLGVGIYQAGSQADAELLYECVSTRARAAIGLASYSGLCVKQGCRPDLLLVHHRDDTGCGVSRPRTNVAEVVWTPPEKLNRDVVSGGRLKVSPFSVADSDALYEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q3Y9</accession>
    <name>W6Q3Y9_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA pseudouridine(55) synthase</fullName>
            <ecNumber evidence="3">5.4.99.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PROQFM164_S02g000831</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a uridine in mRNA = a pseudouridine in mRNA</text>
            <dbReference type="Rhea" id="RHEA:56644"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:14659"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the pseudouridine synthase TruB family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.25" evidence="3"/>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q3Y9"/>
    <dbReference type="STRING" id="1365484.W6Q3Y9"/>
    <dbReference type="OMA" id="FAINKPC"/>
    <dbReference type="OrthoDB" id="9995526at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160148">
        <property type="term" value="F:tRNA pseudouridine(55) synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990481">
        <property type="term" value="P:mRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2350.10:FF:000014">
        <property type="entry name" value="PUS4p Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.10">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01080">
        <property type="entry name" value="TruB_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002501">
        <property type="entry name" value="PsdUridine_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014780">
        <property type="entry name" value="tRNA_psdUridine_synth_TruB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13767:SF2">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE TRUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13767">
        <property type="entry name" value="TRNA-PSEUDOURIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01509">
        <property type="entry name" value="TruB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Pseudouridine synthase II N-terminal" evidence="7">
        <location>
            <begin position="81"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="239"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="268"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="299"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM30681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="405" mass="45195" checksum="E143B571DF249B47" modified="2014-04-16" version="1">MPFPPGFRLFRKTMSGEKILEGVFAVHKPQGVTSADVIRTLQKHFNPSKTFKPWLEEERARRDRESQFQRKRRRHQRLDVKIGHGGTLDPLATGVLITGIGKGTKSLQDFLACTKSYETIVTFGAETDTYDRLGKIVRRAPYEHITREAVEKALEQFRGEIMQKPPIFSALRVNGKKLYEYAREGKMPPIEIKHRPVEVLNMEIVEWYEPGTHEYKWPEVEMTGDEKAVAEKLLDQEASVPAPPAEGDATSQAPEASSTKRKSPPPADEVKDDGAEAAKKQKVSESEAAPIAPEPTAPEPATTEAPVVPAEEPKPQPPAVKIKMTVTSGFYVRSLAHDLGKAVGSCALMSELVRSRQGDYELSPDKVLEYKDLDAGEEVWGPKVEKFLTEWEEKRATKAKAEAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q4V5</accession>
    <name>W6Q4V5_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="6">PPIase</shortName>
            <ecNumber evidence="6">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">cyp10</name>
        <name evidence="8" type="ORF">PROQFM164_S02g001510</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 6">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the cyclophilin-type PPIase family. PPIL3 subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="6"/>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q4V5"/>
    <dbReference type="STRING" id="1365484.W6Q4V5"/>
    <dbReference type="OMA" id="FHEATPK"/>
    <dbReference type="OrthoDB" id="271386at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000041">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024936">
        <property type="entry name" value="Cyclophilin-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625:SF2">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001467">
        <property type="entry name" value="Peptidylpro_ismrse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="7">
        <location>
            <begin position="10"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM31360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="208" mass="22268" checksum="EC1F5CF5C55EB55E" modified="2014-04-16" version="1">MSVTLHTTQGDLKVELFCEAVPQTAENFLALCACGAYNNTPFHRLIPGFMVQGGDISLGPAAHQTSMKPMLEFEIPKGGTSIYHPAAMNQEIHLPSLRHNARGILSMASRPVKDRTAPGSQGATGATINGSQFFITFVPAPHLDGASTVFGKVLNLTPQDEGGDVLTNIEKANVKVDKKGKVSQPKEGDDFEAFKINNVTIHANPFAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q5I1</accession>
    <name>W6Q5I1_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S02g001745</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q5I1"/>
    <dbReference type="STRING" id="1365484.W6Q5I1"/>
    <dbReference type="OMA" id="CEQSNMI"/>
    <dbReference type="OrthoDB" id="3786931at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="417"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="417"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM31595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="460" mass="52633" checksum="7E7B747D9A2CFF27" modified="2014-04-16" version="1">MGKDGGWFENRRDTSGRHRAPFSGQRDTRFVTDLRRDEIRKLTEILHIDNTRARHTGEIVRRMIRELPKDMRRDRWSRTNKHLCDAHQGLNANLMADVFNLVQREVGHHLRKFDAYPDLLKPLDVLILQKLQAIRGMWEKPDPKNKAVSQAWHYEISCCQGCMVARIASDKHALRNLRIALLSRTQTRLNHAPRRLMKFVDTCIDLFPDDVDELYGTSSQFAFILKDTRKACSKAWAKDPAHADSRTPQRRHTDHDKIDKGDRNEKIGKDAHSHQPASEYDPRKKYPQPPPPITLSHPTERAQNISPDVGPFQMAVRSSYHTELDRRSDPNPERITRFLDFADDNYQGLGISTERQSASTFYGHPGNPPSPSTASTLLGTMEEMDKLLEMYKGMGANPYSHSTQYCSLHGGSGASSQCRSPSIYSTGSEWSDEDEDWRMPESGPAARTTWNLLCEQSNMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q5N5</accession>
    <name>W6Q5N5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Succinate/fumarate mitochondrial transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">SFC1</name>
        <name evidence="12" type="ORF">PROQFM164_S02g001426</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q5N5"/>
    <dbReference type="STRING" id="1365484.W6Q5N5"/>
    <dbReference type="OMA" id="KDWYKGG"/>
    <dbReference type="OrthoDB" id="204711at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005469">
        <property type="term" value="F:succinate:fumarate antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000021">
        <property type="entry name" value="SFC1p Mitochondrial succinate-fumarate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049563">
        <property type="entry name" value="TXTP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45788">
        <property type="entry name" value="SUCCINATE/FUMARATE MITOCHONDRIAL TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45788:SF2">
        <property type="entry name" value="SUCCINATE_FUMARATE MITOCHONDRIAL TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="12"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="114"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="218"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDM31276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="322" mass="34682" checksum="2299929523D11714" modified="2014-04-16" version="1">MSAKNVNQQKRTSPAVNLIAGGGAGMMEALVCHPLDTIKVRMQLSRRATAPGVKPRGFVATGVQIVQKETAMGLYKGLGAVLGGIIPKMAIRFTSYESYKGMLANKETGAVSSKATFLAGLAAGVTEAVAVVNPMEVIKIRLQAQHHSLADPLDAPKYRSAPHALFTVVKEEGFSVLYRGVSLTALRQGTNQAANFTAYTELKAALQRWQPAYSDSQLPAYQTTMIGLISGAVGPFSNAPIDTIKTRLQKTRAEPGQSAVSRIMVIAKDMWKTEGYRAFYKGITPRVMRVAPGQAVTFTVYEYLKGKLEGSNWSFVGGSFDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q5P2</accession>
    <name>W6Q5P2_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA primase</fullName>
            <ecNumber evidence="9">2.7.7.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">pri1</name>
        <name evidence="11" type="ORF">PROQFM164_S02g002159</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the eukaryotic-type primase small subunit family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.-" evidence="9"/>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q5P2"/>
    <dbReference type="STRING" id="1365484.W6Q5P2"/>
    <dbReference type="OMA" id="NVTRGFN"/>
    <dbReference type="OrthoDB" id="19606at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005658">
        <property type="term" value="C:alpha DNA polymerase:primase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006269">
        <property type="term" value="P:DNA replication, synthesis of primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04860">
        <property type="entry name" value="AE_Prim_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.920.10:FF:000002">
        <property type="entry name" value="DNA primase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.920.10">
        <property type="entry name" value="DNA primase, PRIM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002755">
        <property type="entry name" value="DNA_primase_S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014052">
        <property type="entry name" value="DNA_primase_ssu_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00335">
        <property type="entry name" value="primase_sml"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10536">
        <property type="entry name" value="DNA PRIMASE SMALL SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01896">
        <property type="entry name" value="DNA_primase_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56747">
        <property type="entry name" value="Prim-pol domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0235">DNA replication</keyword>
    <keyword evidence="2 9" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3 9" id="KW-0639">Primosome</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="485"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="35"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="54"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="485"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDM32008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="506" mass="57119" checksum="0C68B5B79CD99E05" modified="2014-04-16" version="1">MPHSVSSGSAQNDDEMPDAPPVETSTETRVRLEDMFDGDDDGDDDEEFPASADVKMDSPPKEEPPAPTPSGVDPDIMLAFYQRLFPFRYLFQWLNHGIVPTKDFGNREFALTLQNDAYLRYQSYPTADLFRKDILKMNPSRFEIGPVYSTNPRDRKTLRGGQMKPVSKELVFDIDLTDYDDIRTCCVKANICAKCWSFVTMSIKVIDTALREDFGFEHILWVYSGRRGAHAWVCDPRARNLTDDRRRAIAGYLEIIRGGSQSGKKVNIKRPLHPHIVRSLELLKHDFARTTLGDQDTFESAEQAERLLSLLPDKTLNDSLRRKWESSPDRASTSKWADIDSLAKTGKSSTLNPATLRDAKQDIVLEYTYPRLDAEVSKKMIHLLKSPFVIHPGTGRICVPIDPRNAENFDPLSVPTVMNLLAEIDEYDAKHSVGTAEADIPDAEGSAMNGSDIKGSRKVQDYEKTSLKPYIDFFRSFIAGLIKEERAGKRERDDSGPVVKADPMEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q647</accession>
    <name>W6Q647_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">1,3-beta-glucanosyltransferase</fullName>
            <ecNumber evidence="10">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PROQFM164_S02g001916</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Splits internally a 1,3-beta-glucan molecule and transfers the newly generated reducing end (the donor) to the non-reducing end of another 1,3-beta-glucan molecule (the acceptor) forming a 1,3-beta linkage, resulting in the elongation of 1,3-beta-glucan chains in the cell wall. Involved in cell wall morphogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Cell membrane</location>
            <topology evidence="1 10">Lipid-anchor</topology>
            <topology evidence="1 10">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the glycosyl hydrolase 72 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="10"/>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q647"/>
    <dbReference type="SMR" id="W6Q647"/>
    <dbReference type="STRING" id="1365484.W6Q647"/>
    <dbReference type="OMA" id="GVNDYSW"/>
    <dbReference type="OrthoDB" id="421038at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042124">
        <property type="term" value="F:1,3-beta-glucanosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071970">
        <property type="term" value="P:fungal-type cell wall (1-&gt;3)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000032">
        <property type="entry name" value="1,3-beta-glucanosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004886">
        <property type="entry name" value="Glucanosyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31468">
        <property type="entry name" value="1,3-BETA-GLUCANOSYLTRANSFERASE GAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31468:SF5">
        <property type="entry name" value="1,3-BETA-GLUCANOSYLTRANSFERASE GAS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03198">
        <property type="entry name" value="Glyco_hydro_72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 10" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="8 10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6 10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0732">Signal</keyword>
    <keyword evidence="4 10 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005151053" description="1,3-beta-glucanosyltransferase" evidence="10">
        <location>
            <begin position="24"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="438"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="332"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="384"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="336"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="390"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="409"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDM31765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="460" mass="49122" checksum="4C34B76F235D0EBF" modified="2014-04-16" version="1">MKSTVASMATAITLGASTVLGAATNLQARSSDITPITVKGNAFFKGSDRFYMRGVDYQPGGSSNLTDPIADADGCKRDIKYFKELGLNTIRVYSVDNSQDHDECMTALADAGIYLVLDVNTPKYSINRAEPEMSYNDVYLQYIFATIEMFAKYDNTLAFFSGNEVINDGPSSKAAPYVKAVTRDMRTYLRSRKLRSVPVGYSAADVDTNRLEMAEYMNCGTDDERSDFFAFNDYSWCDPSSFTTSGWDQKVKNFTGYGLPLFLSEYGCNINTRKFEEVKSLYSTEMTPVYSGGLVYEYTEAGNKYGLVTVSGDSVTTNSDYKALKTAFDGTKNPTGNGGYNSTGGASGCPKMQKPNWDVDTDALPAMPSPAKKYLTAGAGKGDGFAGKGSQNSGTKSTTTATQGSGDVAAATSGSTTSATSTSSTGAAPSLKPFQFSFAPATVGLVTVVSAVFGASFILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2024-10-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q663</accession>
    <name>W6Q663_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S01g003552</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q663"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM29739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="57" mass="6411" checksum="1F1F7918785174D7" modified="2014-04-16" version="1">MRSADDNLLWVLYIRGETSSIYDWSVVNILVQPTLISAVLTIFGDAKAGYPDDYKSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q675</accession>
    <name>W6Q675_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S02g001956</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q675"/>
    <dbReference type="OMA" id="ISQAYLH"/>
    <dbReference type="OrthoDB" id="4467576at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="34"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM31805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="391" mass="44381" checksum="28A0B10320145A8A" modified="2014-04-16" version="1">MTHTHFIHRVRTVLRRGKRGSMSAGSKASKASGWERLPSHIFVMILASCDLKDIGSLSLSCRALHGRVSKLEFAIAWAYIQLRKQKHPGHCIDGSLSPGDDIAFVSELFPPPPPHYSKGVAHDNASYSLGYLGDLKRCWNTCIRLSHHLADHVVAHHLETSTIAQHLWSSSQTEKEVVYSKAVASLQAKLLYPIAYAVFFLESSASSDSDSDHSGHRHKNMASSIERQQSILRNAPFDDTHIFLSTHHCMQLLFSTVQRLMGPEIPHSSAKSWFSLLLTTSTMERIVSFFVSIAKDNQRKRKGEHDSTWSHRKEFLWAMRWDLNEYNASLGDHGEQSDLEPKINHIWFQAAQNEMDRRGAIPHTVQDSELHVLHGSIVRLECEYCYDCYDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q6G4</accession>
    <name>W6Q6G4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Vacuolar ATPase assembly integral membrane protein VMA21-like domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PROQFM164_S02g002429</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for the assembly of the V0 complex of the vacuolar ATPase (V-ATPase) in the endoplasmic reticulum.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Endoplasmic reticulum membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Endoplasmic reticulum-Golgi intermediate compartment membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Cytoplasmic vesicle</location>
            <location evidence="6">COPII-coated vesicle membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the VMA21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q6G4"/>
    <dbReference type="STRING" id="1365484.W6Q6G4"/>
    <dbReference type="OMA" id="AMKEDQT"/>
    <dbReference type="OrthoDB" id="160405at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033116">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070072">
        <property type="term" value="P:vacuolar proton-transporting V-type ATPase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03058">
        <property type="entry name" value="VMA21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019013">
        <property type="entry name" value="Vma21"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31792">
        <property type="entry name" value="VACUOLAR ATPASE ASSEMBLY INTEGRAL MEMBRANE PROTEIN VMA21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31792:SF3">
        <property type="entry name" value="VACUOLAR ATPASE ASSEMBLY INTEGRAL MEMBRANE PROTEIN VMA21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09446">
        <property type="entry name" value="VMA21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="2 6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM32278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="107" mass="11335" checksum="04705BECDAE67B45" modified="2014-04-16" version="1">MSSRRPDNQSYADVAAKPEPQGTSDVAPAVPADVIYKLLGFTAAMIVGPIGMYFLTVNSIFSGSSTLAGITAAVTANAVLFTYIYVAWTEDQEDRQAASKPDSKKAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q6L1</accession>
    <name>W6Q6L1_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">dihydroxy-acid dehydratase</fullName>
            <ecNumber evidence="14">4.2.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">PROQFM164_S02g000038</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(2R)-2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H2O</text>
            <dbReference type="Rhea" id="RHEA:24809"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:49072"/>
            <dbReference type="EC" id="4.2.1.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:24810"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>(2R,3R)-2,3-dihydroxy-3-methylpentanoate = (S)-3-methyl-2-oxopentanoate + H2O</text>
            <dbReference type="Rhea" id="RHEA:27694"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:35146"/>
            <dbReference type="ChEBI" id="CHEBI:49258"/>
            <dbReference type="EC" id="4.2.1.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:27695"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="13">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 3/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="12">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 3/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IlvD/Edd family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.9" evidence="14"/>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM29889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q6L1"/>
    <dbReference type="STRING" id="1365484.W6Q6L1"/>
    <dbReference type="OrthoDB" id="3851628at2759"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00057"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00061"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004160">
        <property type="term" value="F:dihydroxy-acid dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.30.80:FF:000001">
        <property type="entry name" value="Dihydroxy-acid dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.80">
        <property type="entry name" value="IlvD/EDD C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050165">
        <property type="entry name" value="DHAD_IlvD/Edd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042096">
        <property type="entry name" value="Dihydro-acid_dehy_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004404">
        <property type="entry name" value="DihydroxyA_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020558">
        <property type="entry name" value="DiOHA_6PGluconate_deHydtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056740">
        <property type="entry name" value="ILV_EDD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000581">
        <property type="entry name" value="ILV_EDD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037237">
        <property type="entry name" value="IlvD/EDD_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00110">
        <property type="entry name" value="ilvD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002068">
        <property type="entry name" value="PRK00911.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21000:SF13">
        <property type="entry name" value="DIHYDROXY-ACID DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21000">
        <property type="entry name" value="DIHYDROXY-ACID DEHYDRATASE DAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24877">
        <property type="entry name" value="ILV_EDD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00920">
        <property type="entry name" value="ILVD_EDD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143975">
        <property type="entry name" value="IlvD/EDD N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00886">
        <property type="entry name" value="ILVD_EDD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00887">
        <property type="entry name" value="ILVD_EDD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dihydroxy-acid/6-phosphogluconate dehydratase N-terminal" evidence="18">
        <location>
            <begin position="58"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="Dihydroxy-acid/6-phosphogluconate dehydratase C-terminal" evidence="19">
        <location>
            <begin position="403"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00052865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF24877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CDM29889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="597" mass="63677" checksum="451FB356E44CED7D" modified="2014-04-16" version="1">MAEYARFPSLPDNAKHEDGTPVLNRHSTFITRGHDFPAAKAMLYGAGVPDPEAMAKSPHVGIGSVWWERNPCNMHLLDLGKTVKKAVQEQDMIAWQYNTIGVSDGITVGHEGMRFSLQSREIIADSIETVTCAQHHDACIAIPGCDKNVPGVVMGIARHNRPSVVIYGGSIQIGFSKTLRKRITLGSAFEAAGAYTYDTLQDLATEDSIKGLHTNDEIMDDIEQHTCPTAGACGGMFTANTMATAIESLGLSLPGSASTPASSPSKMRECVKAAEAIKVCLERNIKPSDILTKRSFENALVMVVALGGSTNAVLHLLAMARTADIDLTLDDIQSVSNRIPYIADLAPSGKYYMPDLYEIGGIPSVQKLLIAAGLLDGDIPTVTGKTLAENVAGFPSLPADQVIIRPLNSPIKETGHIQILRGNIAPGGSVAKITGKEGTRFVGKAMVFDKERHLNQALDKGEIPRGENIVIVVRYEGPKGGPGMPEQLKASAAIIGAKLTNIALITDGRYSGASHGFIVGHIVPEAASGGPIAVVQTGDVITIDAQKNQISMNVSDEEMKRRLHNWKPPKPAITRGTLGKYSRLVSDASHGAMTDLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q727</accession>
    <name>W6Q727_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S02g002679</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q727"/>
    <dbReference type="STRING" id="1365484.W6Q727"/>
    <dbReference type="OMA" id="TTYKITC"/>
    <dbReference type="OrthoDB" id="4991875at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40640">
        <property type="entry name" value="ANCHORED GLYCOPROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04860)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40640:SF1">
        <property type="entry name" value="ANCHORED GLYCOPROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04860)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004879626" evidence="2">
        <location>
            <begin position="18"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM32528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="251" mass="24634" checksum="BCDD68F7678B6093" modified="2014-04-16" version="1">MRFYTVALLAGATAAAAGNTATLLLPGFKGQDLEASIIESNGDATTYKITCPKTVAACGIAGEGMTAIAAPTSMQLQNIDLQGTLGTVSCNIAGTTYASCQASAGTVTPSGTLAQEDLNWMPVTISATPTPTSTSTPTHTPTSTSTSTSTPTPTSTSSEISTSTTEVSSTFTPTITSSPTLVISTTKKPSSALISSAPVASSTPLVVASTSAAASGSAPAASATAYNAAGQLVGSIWTVGGAFLALACAFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q753</accession>
    <name>W6Q753_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S02g001942</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q753"/>
    <dbReference type="STRING" id="1365484.W6Q753"/>
    <dbReference type="OMA" id="RQEEAMV"/>
    <dbReference type="OrthoDB" id="4477787at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004879627" evidence="1">
        <location>
            <begin position="22"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM31791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="198" mass="22341" checksum="E3F0446215817514" modified="2014-04-16" version="1">MRLFLDRLFLVIVLLFSPVTALGTSCFKVVSALVSRPAHLFGKFQSEICDVGCQPTVPHWDLWTRNNTFVPAVRSLMQRMNVPHKEEALLKMGDDVALKIKESCGPMLGGGVHICSDPETLAGFGNCFKRNFLKASIKHLPTLIPMASEESCKEQLRFLESDELWDTTIPQNMRDYAKVCDTLGFMTMMNYELYPDST</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q7F2</accession>
    <name>W6Q7F2_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Amine oxidase</fullName>
            <ecNumber evidence="6">1.4.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PROQFM164_S02g000338</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a secondary aliphatic amine + O2 + H2O = a primary amine + an aldehyde + H2O2</text>
            <dbReference type="Rhea" id="RHEA:26414"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:58855"/>
            <dbReference type="ChEBI" id="CHEBI:65296"/>
            <dbReference type="EC" id="1.4.3.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the flavin monoamine oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.-" evidence="6"/>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q7F2"/>
    <dbReference type="STRING" id="1365484.W6Q7F2"/>
    <dbReference type="OMA" id="PIHWAGT"/>
    <dbReference type="OrthoDB" id="5046242at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097621">
        <property type="term" value="F:monoamine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.660.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.405.10">
        <property type="entry name" value="Guanine Nucleotide Dissociation Inhibitor, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001613">
        <property type="entry name" value="Flavin_amine_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050703">
        <property type="entry name" value="Flavin_MAO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43563">
        <property type="entry name" value="AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43563:SF14">
        <property type="entry name" value="AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00757">
        <property type="entry name" value="AMINEOXDASEF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0274">FAD</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004879967" description="Amine oxidase" evidence="7">
        <location>
            <begin position="31"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="Amine oxidase" evidence="8">
        <location>
            <begin position="44"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="64"/>
            <end position="65"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="379"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="462"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR601613-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM30189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="489" mass="52997" checksum="22DFE4696EDFBE4A" modified="2014-04-16" version="1">MRIIYCRSSFSAMHLFVIAIPLCHVLVAECFIPKVDVAIIGGGLSGLSTAKDLAAANKSFVILEARDRVGGRVLNFNLTGKNIQELGGEYVGPTQNRVLALAAELGLPTYKTYTTGNSTFYRNNTVHHYQDTLGGIPPVGIGSLIELAFFMNDINTLASKVDLEAPWNTPNATALDSMTLETYVSSRLSTADSRVLLDIAIPAILSTELREPSLLYALWCIAAAGDKTGPGTINRLIGVEGGAQDSRVSGGTQLLATLLAERLGSQNIYLNTPVRKVQLKKSRYLVSSDEVNISARHVVVAMSPPLASHIIFDPLLPAGRDQLNQRMPMGALGKAIAIFPTAWWRDEGLNGEGVSDIGAIRVTYDNSPADDSFGAIMGFIEADEMRKLDTASEEEVKRQVKQSFANLFGPRVENATDILVQRWDLEEFSRGGPSAFMPPGVLTQYGSYLRTPVGRIHFAGTETSLRWIGYMDGAISSGERVAGEILKTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q7M1</accession>
    <name>W6Q7M1_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Negative regulator of mitosis</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">bimE</name>
        <name evidence="9" type="ORF">PROQFM164_S02g002506</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the APC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1365484.W6Q7M1"/>
    <dbReference type="OMA" id="YIGTMDS"/>
    <dbReference type="OrthoDB" id="26401at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007091">
        <property type="term" value="P:metaphase/anaphase transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070979">
        <property type="term" value="P:protein K11-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000217">
        <property type="entry name" value="20S cyclosome subunit (APC1/BimE)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000400">
        <property type="entry name" value="20S cyclosome subunit (APC1/BimE), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024990">
        <property type="entry name" value="Apc1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048971">
        <property type="entry name" value="Apc1_3rd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049255">
        <property type="entry name" value="Apc1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12827:SF3">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12827">
        <property type="entry name" value="MEIOTIC CHECKPOINT REGULATOR TSG24 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12859">
        <property type="entry name" value="ANAPC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21282">
        <property type="entry name" value="APC1_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0498">Mitosis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Anaphase-promoting complex subunit 1 N-terminal" evidence="7">
        <location>
            <begin position="29"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="domain" description="Anaphase-promoting complex subunit 1 beta-sandwich" evidence="8">
        <location>
            <begin position="1760"/>
            <end position="1839"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="91"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="217"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="339"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="803"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="228"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="339"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF21282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM32355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="2052" mass="226342" checksum="7D2A9E2DFFBCA564" modified="2014-04-16" version="1">MASVRSLGVHEPSAISYLVAEGILPQEPSEDHYNWTLCVDESGLTGPVDDELVWTKHCVVWSRAGMVKRVFRMDPEKEEIRHALFTRFAAEDTKRAKPTPPSRPEATTGTQKQKRTETFSTLDLHGDARVAVVAPQHSNEALSRALVVVLKSQAHIFFVAGNSHTIPLPFEVDSVFATPRGLIFQRKVQNENSSSQQPTAPPNSFVSSLFDPGASQSFSLSKNKRPSTKSSSAPGPSWVPNTASSTDLPRVFSLINPHSEMGLVVTSQTSRWLQSSITSTRKRPSGLEVLDPVDEIVYISPKDELSGINRPNSGPLILVVTINTTTGIYTVWTAHYKDDESGGSMKDKTRRETGGTRSVRRSSHFGMATGATTPAARSGAGRESFGPRTDNWPSTQLSEGRNDAEDDLASRVAQDFGDVGVPLKTSRRVSSLLARTDLATSQDRITFSDLATGSQSSNMPHGAGFRQSLGASMRGSFGFNPRGSLPPGTGSVYSTAGSFLDTPVDKLLEELNNDSLSSGFDNIALRESTSGLPEELILTKVESFSSQFSGSFQKEPASRRLKISTLASTEFGSAHKGNTTFLAVYIVDQEARKLTIVNLRADRQPAPKNRKKKSKTSLLVRAVRIQNVSNVLDACRISDGDLSRILSLSETESGQRELSLQTLWGSPVKVEVPIPLQLYEPDGISANKLESRPRESGVHRVMADPSLVFNKFDHGCSRGKVDLVDTDKKRHRLQIRMEPRNELVKKILKICMFALRESEKAGDGITVAWWEVMKWLRGKEEDNIEWTAMTVVLLSLAAPFVTPPQTQTPKRTRRKKGLLRSSSGGHLDLESWESMLDLESGSSGVVAPWMMDGSWGWIVEQDAIESLASGDAPKGVNASRSTYRQNSYLIRCIALSREFLQSPEGLRAAGRDGYLPISEAFSENTRCTALCSVLVALHLLREEQKLSTCDSEESQRPLGLLAPVIAQLGSWLGWESWTWAEDAYYGTEMASMERWQFEDNTHIAGLKVPAEPFPPPSIFEFLMGAAAHRSPTPFVSLLDIVNAAERTPRKGRMWRECFGITPRTCALNGFFTEVHSVSTPLEKIKLLQRWGFTKSVIDSFPEGVSAPLYEAVMQCQIEASTSWNATLLEMIDREDLYMSMNPAQPSSLAAPQQPNHNAVRDFHYISSSALDIDATNAFEASAEADRYSVTRLIFREDKRFVEAGKLLNQSKAPVAECIAEPGWSDSDLLEAQKEIVQLVTVRTLSTPAGRAMLTFSGRLPLLTEKLPIPSFSLQCVMKPDNVTVSADKSAFSEEKVCWAFFHNGVSTGLAISKASKGIDTSWILFNKPQDLTNRHAGFLLALGLNGHLKSLAKWVAFKYLTPKHTMTSIGLLLGLSASYLGTMDTLITRLLSVHVTRMLPFGAAELNLSPLTQTAGIMGIGLLYCGSQHRRMSEVMLSEIENSEQDEQAAATGEELRDEGYRLAAGFALGFINLGKGDDLRGMRDMHIVERLLSIAVGTKTVEIAHVLDRATAGATIALMIIFMKTNDSVLAKKIDIPDTTVRFDYVRPDIFLLRTLARHLIMWDSIKPTAEWISQSLPEVYRGRSQLSEVRRLRSEDMPFFNIIAGLCFAVGLRHAGSGQAQARDLLLFYLDQLIRISRLPVRSYDARLARNSVRNCQDLVALSAAAVMAGTGDLALFRRLRSLHGRIDADTPYGSHMAAHMAIGVLFLGGGSYTLGTSNRAVTALICAFYPIFPTTVLDNKCHLQAFRHLWVLAAEPRCLIPRDLDSRRPISIPITITSHDETTRTVSAPCLLPDLSSIARIEIRGPDHWPLVLDFSQNDALREKFLRGDPSIYLRRKATYSPSSSTSVFASTLTGLSEAQDILPATAGPLSNPAKGLPPSAWPTRMALLTGKASTLITPSQTPWDWVFHLPSLQDLDIRERSLVLPSSFPMRSVRITTDLVSVPPWLRTSAVDARLALSHTVRNIVQSARGRGADPDQIRDRIWQLRLLFDWLDRTQPGDERDHLSSRGLLSSTQGQPSGLWLRRDFVEEAKWQVWGVQVGDLEGENQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2024-10-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q8P1</accession>
    <name>W6Q8P1_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S02g002891</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q8P1"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM32740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="63" mass="7143" checksum="41428FA934436BC8" modified="2014-04-16" version="1">MAPGNRVCQNRSPARDVFSSVNNLRLNATRTTEINPCLQFFGHHRWITFEWNLVVLTGGAVQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q8X6</accession>
    <name>W6Q8X6_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S02g002981</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q8X6"/>
    <dbReference type="OrthoDB" id="4365268at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM32830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="299" mass="33948" checksum="42B795650A68AF5F" modified="2014-04-16" version="1">MNGGVYEPLAVRIPRSYPITTVQFIITGGTLMFPLLESKRASALSARAPRYRCDPTLYHPDMTIGGIDDEPMPCADASTRYIREIPMAYTTVCLSAFEHGAEKCRCLVLHNDRGFLPSPLAMLLVQIRVQGEATNREDKAVYTEAQPSQLKSQKDRPILSHLVPRVAQAFDTYERVEMNQAEIYGATSSRSQKCLLGTGAWCIWIPSTHFSIKAQQLSRKSYMLWMSLKLQVTKLAARLCLLMSFSNLSRKQLLPGASSDSVHQRRHPFSIKYIFVKLTTPWTIFDRSLFKQILYEDEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q949</accession>
    <name>W6Q949_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Probable transposable element</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g000066</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q949"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM26257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="102" mass="11690" checksum="65FD205D84D7DAAE" modified="2014-04-16" version="1">MDPTTLFRMEPPTPEQTEHQSKEGIWTRGLDQNRRGSSSIDEPMEADQDQANTRPGSGTPYSGDGLGGRPVYTRQRPTLYSKRWFTPDLKAQQVEVNQLRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q9L7</accession>
    <name>W6Q9L7_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">TATA-binding protein-associated factor mot1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Modifier of transcription 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">NCT transcriptional regulatory complex subunit mot1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">MOT1</name>
        <name evidence="20" type="ORF">PROQFM164_S03g000047</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Regulates transcription in association with TATA binding protein (TBP). Removes TBP from the TATA box via its C-terminal ATPase activity. Both transcription activation and repression require its ATPase activity. Part of the NCT transcriptional regulatory complex that acts as a key regulator of ergosterol biosynthesis and the azole exporter cdr1B. The NCT complex binds the promoters of genes linked to azole susceptibility, and especially represses the expression of cdr1B transporter.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Forms the NCT transcriptional regulatory complex with nctA and nctB.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1365484.W6Q9L7"/>
    <dbReference type="OMA" id="WYSDIAC"/>
    <dbReference type="OrthoDB" id="10252227at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17999">
        <property type="entry name" value="DEXHc_Mot1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000009">
        <property type="entry name" value="B-TFIID TATA-box-binding protein-associated factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000508">
        <property type="entry name" value="Probable helicase mot1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000445">
        <property type="entry name" value="Related to MOT1-transcriptional accessory protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000428">
        <property type="entry name" value="TATA-binding protein-associated factor 172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044972">
        <property type="entry name" value="Mot1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044078">
        <property type="entry name" value="Mot1_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022707">
        <property type="entry name" value="Mot1_central_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36498">
        <property type="entry name" value="TATA-BINDING PROTEIN-ASSOCIATED FACTOR 172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36498:SF1">
        <property type="entry name" value="TATA-BINDING PROTEIN-ASSOCIATED FACTOR 172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12054">
        <property type="entry name" value="DUF3535"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="18">
        <location>
            <begin position="1332"/>
            <end position="1505"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="19">
        <location>
            <begin position="1679"/>
            <end position="1830"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="184"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="253"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="714"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="272"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00053370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00064550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00073046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00081280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00081329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CDM33323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="1908" mass="212216" checksum="9DDE60D02C66E65D" modified="2014-04-16" version="1">MASRLDRLVTLLETGSTQLIRNTAAQQLADVQKQHPDELFNLLGRILPYLRSKSWDTRTASAKAIGLIVSNADIYDPNEDDGLQIKSAADEDDVEIKSEVKSEELVLADDFLKLDTLDIPSVLKYGKRLLGSAGKEYEYSLASMEPASRLQHQKKTLTARLGLEGEYLEEDLIEDIDLPPKVVTPALKNEPTIPSISHHNSRHEARSRMPSSPSESATKEDGGLSKRQLNQLKRKNKQNAKMGANKVRVVDLSSRRQSDIATTPMATTPHPVKAENGDNQDGDPKPDYFSFERTEEDDDSKLVSEFKGAVIPERPLIQPEIVEQGAGWPLEHMCEFLTMDIFDSNWEVRHGAAMALREVIRVQGVAAGRLDGKSRPENDALNRRWLDDLSCRLLCVLMLDRFGDYISDNVVAPIRETVGQTLGALLSHLHPNSVRAVYRCLYRIIMQTDLGLNRPVWEVCHGGMIGMRYLVAVRKDLLVKDSNMMDGVLEAVMKGLADYDDDVRAVSAATLVPIAEEFVSSRTGTLGPLMNIVWDCLSNLQDDLSASTGSVMDLLAKLCTFPQVLDAMKANAADDPEASFGKLVPRLYPFLRHTITSVRSAVLRALMTFLKLEGEGTTDWVDGKALRLIFQNLLVERNEGVLKLSGQVWSELLNVVELRGSFKSEEELSDSIQPLVTLTLGAFGVPRYPIPMNTSLFIKPSGLPFSAALPAPIPPKGSPPASIPGGAEIKVGRRRKSEKKEKEPPPPSAHNVDGHMLSGDIDLVGADTMLRSKIYAAKALGELISFWDKNELPSLWPAILDGLNVSASTTQLASAMVIEEYARQSGLESKYRSSLCDRLRPILEGERPAWYADIACYLHVARSQCHSLLNTFRDHAHVAPSRLPTLAVVVQGDPEAGPNAFSLADAEKIVGPDFDRLKKNLTPAQRITATQVLNDTRTTAQSAVEEARLMREQRDMRVLAATAGALVALRDIPKKPGHIIKGMMDSVKKEENLELQQRSATAVAGLIEHYTAATKRGPVDKIIGNLVKYCCVDTSETPEFPHNVHLEKSILSLRKEEDRRDHPDAAKFEREAREARIMRRGAKDALEQLAVKFGAELLEKVPNLAKLVERPLKDALTEDDLPENITDPENPLGQEIVDGLSTLRALLPKFDPGLHQWVIDLMPIIAKGLQCRLSVIRYAAAKCFATICSVITVKGMTMLVEKVLPIINNGLDVNHRQGAIECIYHLIHVMEDGILPYVIFLVVPVLGRMSDSDNDVRLLATTSFATLVKLVPLEAGIPDPPGFSEELLAGRDRERKFMSQMLDVRKVEPFEIPVAIKAELRPYQQDGVNWLAFLNRYNLHGILCDDMGLGKTLQTICIVASDHHMRAEEFAKSQSTDSRKLPSLIVCPPSLSGHWQQEVKQYAPFLSCIAYVGPPAERTRLQPLLATTDVIVTSYDVCRNDNDILSPMNFNYCVLDEGHLIKNPKAKITSSVKKLASNHRLILSGTPIQNNVLELWSLFDFLMPGFLGTEKVFLDRFAKPIAASRFSKSSSKEQEAGALAIEALHKQVLPFLLRRLKEEVLNDLPPKIIQNYYCDPSELQKKLFEDFSKKEQKELADKVGSADRGDKEHIFQALQYMRRLCNSPALVVKEGHKQYNEVQSFLTAKRSNIRDISHAPKLTALKDLLVDCGIGLDHTAEGELDTGASYVSPHRALVFCQMKEMLDIVQNDVLKKLLPSVQYLRLDGSVEATKRQDIVNRFNTDPSYDVLLLTTSVGGLGLNLTGADTVIFVEHDWNPQKDIQAMDRAHRIGQKKVVNVYRLITRGTLEEKILNLQRFKIDVASTVVNQQNAGLGTMDTDQLLDLFNLGETADTAEKPGDPAGNEVDMVDIDGEVKEKGKKGWLDDLGELWDDRQYQEEYNLDSFLETMKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W6QA47</accession>
    <name>W6QA47_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Hly-III-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PROQFM164_S02g003027</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ADIPOR family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QA47"/>
    <dbReference type="STRING" id="1365484.W6QA47"/>
    <dbReference type="OMA" id="EVPSWYA"/>
    <dbReference type="OrthoDB" id="529367at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004254">
        <property type="entry name" value="AdipoR/HlyIII-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855:SF52">
        <property type="entry name" value="ADIPONECTIN RECEPTOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855">
        <property type="entry name" value="ADIPOR/PROGESTIN RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03006">
        <property type="entry name" value="HlyIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="79"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="210"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="244"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="281"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="14"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="283"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR604254-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM32876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="313" mass="35245" checksum="092135B02F9550AE" modified="2014-04-16" version="1">MALLRRLSPAERASGTDRSDSPLLKEPRSPSGPRLLNRDEVPSWYGHNPYIRTSYRPVTPSTSRCLSSLLYLHNETVNVYSHLIPAIITSLGNGLLYFYFTASFPDATGVDQLVFHIYLTTSVVCFGVSSAYHTFLCHSAPFSALWGRLDYVAIVFQILGSFVSGIYIGFYCEPHLQKLYWSMIGTLGFLTGFVVVHPRLQSQKWRLLRLSTFVATGLSAFAPIIHAASIFPYDQLDQQAGLRYYYLEGLAIVIGVLFYATHFPESWKPGSFDIWGSSHQIFHIAVVIGATIHLYGILVAFQWNYENQRCHIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W6QAE2</accession>
    <name>W6QAE2_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">galacturonan 1,4-alpha-galacturonidase</fullName>
            <ecNumber evidence="13">3.2.1.67</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">rgxC</name>
        <name evidence="17" type="ORF">PROQFM164_S03g000079</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Specific in hydrolyzing the terminal glycosidic bond of polygalacturonic acid and oligogalacturonates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>[(1-&gt;4)-alpha-D-galacturonosyl](n) + H2O = alpha-D-galacturonate + [(1-&gt;4)-alpha-D-galacturonosyl](n-1)</text>
            <dbReference type="Rhea" id="RHEA:14117"/>
            <dbReference type="Rhea" id="RHEA-COMP:14570"/>
            <dbReference type="Rhea" id="RHEA-COMP:14572"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58658"/>
            <dbReference type="ChEBI" id="CHEBI:140523"/>
            <dbReference type="EC" id="3.2.1.67"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the glycosyl hydrolase 28 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.67" evidence="13"/>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QAE2"/>
    <dbReference type="STRING" id="1365484.W6QAE2"/>
    <dbReference type="OMA" id="FWNVSEV"/>
    <dbReference type="OrthoDB" id="339764at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047911">
        <property type="term" value="F:galacturan 1,4-alpha-galacturonidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000743">
        <property type="entry name" value="Glyco_hydro_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31736">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31736:SF12">
        <property type="entry name" value="EXO-POLYGALACTURONASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00295">
        <property type="entry name" value="Glyco_hydro_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="10" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 15" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 16" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004881888" description="galacturonan 1,4-alpha-galacturonidase" evidence="16">
        <location>
            <begin position="24"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU361169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CDM33355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="425" mass="46679" checksum="B5549C6A58B4F977" modified="2014-04-16" version="1">MRFFGIPSLAMPLWLTVSPFVYANEERSSNVCIVKANGHQRDDVPNILEAFQRCGNGGTIIFPEDQAYWIGTRLNPVVSNIQIEWRGKWTFSDDLDYWHNHSYPVAFQNHAAGFIITGHNITIDGYGTGGIDGNGNTWYTAEKGDTQPGRPMPFVFWNVSDVSVENFYVKDPQLWAVNIMNGTNMRFNNIYCNATAVDAPYGENWVQNTDGFDTMDVQNVQLSNFVYQGGDDCVAIKPRSYNVDIHNVTCRGGNGIAIGSLGQYQEDSSVANIRIDTVKVIRYNDDMHNSAYIKTWVGALVPQSSYENAGLPRGGGWGSIRNVLFSNFEVHGANAGPTVKQDNGNNGSYSGTSLMSISNVAFVNFTGYIESTSTNVASVSCSNVHPCYNIDFDNVILYAQENATTPGIGSCKYTLEGGVHGLDGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W6QAP3</accession>
    <name>W6QAP3_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S02g003258</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM33106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QAP3"/>
    <dbReference type="OMA" id="VYWDMDR"/>
    <dbReference type="OrthoDB" id="5401170at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM33106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="256" mass="29658" checksum="A133FA180AA204C4" modified="2014-04-16" version="1">MDDDDHVPRSWFPEGLDPGDEVTLNKPTRSEWVIDRLVNKHSYQCADRSLDSYACVLFECHNAAGGQEAFMRVYAQVPHTCYEDADRATRTREATEFTPPELKAYKFLKDKCSQNTPLLLAYKQGSQDSRSGAVPRGHLTWIVWEKVPGDRLGDFKSAFVYWDMDREERKRVREAFLRELPKAQHMGYFPEGARPRNLVWNSDTGALYFVGFRDAEGFKAKGTFGIEWLPRFDLARPPRSYLWNKSFNGDISDWKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>W6QAQ4</accession>
    <name>W6QAQ4_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein-lysine N-methyltransferase EFM4</fullName>
            <ecNumber evidence="5">2.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Elongation factor methyltransferase 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">EFM4</name>
        <name evidence="8" type="ORF">PROQFM164_S03g000264</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that mono- and dimethylates elongation factor 1-alpha at 'Lys-316'. May play a role in intracellular transport.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM4 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="5"/>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QAQ4"/>
    <dbReference type="STRING" id="1365484.W6QAQ4"/>
    <dbReference type="OMA" id="PTPSFQF"/>
    <dbReference type="OrthoDB" id="10069295at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03188">
        <property type="entry name" value="Methyltr_EFM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026635">
        <property type="entry name" value="Efm4/METTL10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12843:SF5">
        <property type="entry name" value="EEF1A LYSINE METHYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12843">
        <property type="entry name" value="PROTEIN-LYSINE N-METHYLTRANSFERASE METTL10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Methyltransferase" evidence="7">
        <location>
            <begin position="107"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="35"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="152"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="38"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="161"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM33540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="339" mass="37789" checksum="B26D9F2EBDFA9AA8" modified="2014-04-16" version="1">MAEESHPAYLSPSELGTKDYWESYYARTLAHISHEAPKNNPNANANPDQNDDDAASTTSDLNEEDDPGTSWFSEHNAPQKVLRFLTRKSFPLSPRNTAHKKGARQPSVLDLGTGNGSMLALLRKRGGYIGRLVGVDYSRQSVELARELQRVRGHSAYRSDSEDEDESESDDEEEEEAEAEAEEDTGSKDLPGQDTSIQFEEWDILGSKAVLSETGLEVSPSSSSPSEETLPWFPYDQGGFDIVLDKGTFDAVSLADDAKTTRVCERYPDIARHLVRRGGFLIVTTCNWTEEELVHWFTGERTSGDRLVVWGRVEYPRFRFGGHEGQGVCTVCFQRLGDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W6QAU7</accession>
    <name>W6QAU7_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oxoglutarate/iron-dependent dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S01g000651</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QAU7"/>
    <dbReference type="STRING" id="1365484.W6QAU7"/>
    <dbReference type="OMA" id="WCTLILT"/>
    <dbReference type="OrthoDB" id="4366673at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="2">
        <location>
            <begin position="16"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM26842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="184" mass="20068" checksum="259A15C3044445FC" modified="2014-04-16" version="1">MPFSILAGTDLSAAHTSYNMNYRLCDYNPNTAAPGSSNGCGAHTDYGTFSSIFQDGTPGLELEETPGTWVLVPGDATVVLTGWCAVILSGSRVSAAKHRVCRSPGVRRLSAVLFVAPDLDVKLKPLGDSQPIRSFSETIMRGDLDVETFKDVMGKRWRYREGNEEMDNADSLSQDNEIENMVWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W6QAX2</accession>
    <name>W6QAX2_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Inhibitor of apoptosis-promoting Bax1-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PROQFM164_S03g000339</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the BI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QAX2"/>
    <dbReference type="STRING" id="1365484.W6QAX2"/>
    <dbReference type="OMA" id="TLMWSER"/>
    <dbReference type="OrthoDB" id="1277691at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006214">
        <property type="entry name" value="Bax_inhibitor_1-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23291">
        <property type="entry name" value="BAX INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23291:SF112">
        <property type="entry name" value="GROWTH HORMONE-INDUCIBLE TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01027">
        <property type="entry name" value="Bax1-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="119"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="232"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="270"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDM33615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="336" mass="36933" checksum="8875BA556C22CCE0" modified="2014-04-16" version="1">MAFFLRRPFAVSSALRQVPKLTNTARFIHNSPIKPTQAAKPQGVSSIFAQSRQNFQNAFRRTYMQQSVNPAQDGNLTQKLVYGAAIIGGTILATNFIFNRETREDGGMPAYERSFLNETFVHTGLGIGIIGVAARALHMSGWSYRLMAMNPWLVMGVGLVGSIGSMYGTFYTSPDNYVLKYGCWTLFNVTQAALLSPLMFMNPAILARAGLYTVGMMGSIAFVGATAKQEKYLYLGGPLLAGVAIVALSGLAPMVLPATAARTLMWSERVWLYGGLAVFGGFTLYDVQKILHHARLAERGLIKRDVVNESVSLELDFINIFIRMVQILGMGNNHRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W6QAY2</accession>
    <name>W6QAY2_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S03</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S03g000349</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QAY2"/>
    <dbReference type="STRING" id="1365484.W6QAY2"/>
    <dbReference type="OMA" id="WFADSNG"/>
    <dbReference type="OrthoDB" id="76567at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM33625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="267" mass="29461" checksum="C51106CDB683F416" modified="2014-04-16" version="1">MSNSGVTAALSFPSALPDNHMVRVFTSMNRLRTAANEVFASLDNKQSTNQWLLVLGLPTTVIKRLDEDRNCLEAINYRFQWQGRSGLIKVIPTAQHEIITTRVMFSVNDALAAMGLHWSDSEWVGHTTYKPNLAKGKQPDNAFLPPSRCTIPLSSTGWPTLLRADAAKWFADSNGDVRIALVIAIKDSRVDIEKWQLAPEGASPLDLQVPDSQQPYCAQEITITPQGVTGTPLVLPFTALYDRVPGPGETDVLITTADCLKITTRMW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2024-10-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W6QB96</accession>
    <name>W6QB96_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S03</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S03g000015</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QB96"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM33291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="40" mass="4637" checksum="420B5C9CCA0719CD" modified="2014-04-16" version="1">MSMTQGSQVIRFDTAVVPEKEDLEEVASKLVRRLKDWRST</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W6QD38</accession>
    <name>W6QD38_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S03</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S03g001332</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QD38"/>
    <dbReference type="STRING" id="1365484.W6QD38"/>
    <dbReference type="OMA" id="LQGMHIL"/>
    <dbReference type="OrthoDB" id="2534759at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38702">
        <property type="entry name" value="CALPONIN-HOMOLOGY (CH) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38702:SF1">
        <property type="entry name" value="CALPONIN-HOMOLOGY (CH) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM34608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="506" mass="57029" checksum="985A38A798CEC7C2" modified="2014-04-16" version="1">MDAPRRSMDSKPAASIRDSSPSPSIPATPAISSYSSPDRTFSSESSRSTSSATSADARSSVSTSSRRHGYTRALGAKFSESARHRDSVMSLGSIAHLQYYFARTGLLDGKSGRSREWEKNKKNRNNVPRVLITPNQRHMDDDLVASPSGMADLTEGEFEFEDEDAEVMLPPTVSTYSIKTHHIPPPPGLLFLRRQLTLALDKAESNIEAIQNGMEPPPRPILRSSLSPDDVPNEDDQSGQAAPPMNKEELQGMCILDDVTNAIRAAKIYYTTHEYPERLASIKSERDIRKELLDVLEVLKRFSARHFASGLREEEREKIQGWIAAVRVMLIQEKKLEDLEAQERQNWDWAAGDWTGRERSREESFLRSLLPGGDSLPTWTPVEETPADSLPTAFLDRFRDGRALVQLHNLAIKKSKRKFGDITAYHLDIEKPYRQTENLQFWVKAAELRWELRLDVDVMGVVQNSGTTAWEQFDTALLAWCKTVREELVRDWQEANPGRPPSAGLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W6QE41</accession>
    <name>W6QE41_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pectin lyase fold/virulence factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S03g001466</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QE41"/>
    <dbReference type="STRING" id="1365484.W6QE41"/>
    <dbReference type="OMA" id="AVFMNWN"/>
    <dbReference type="OrthoDB" id="1046782at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23668">
        <property type="entry name" value="GH55_beta13glucanase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000023">
        <property type="entry name" value="Exo-beta-1,3-glucanase Exg0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000026">
        <property type="entry name" value="Exo-beta-1,3-glucanase Exg0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051801">
        <property type="entry name" value="GH28_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024535">
        <property type="entry name" value="RHGA/B-epi-like_pectate_lyase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31339">
        <property type="entry name" value="PECTIN LYASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31339:SF9">
        <property type="entry name" value="PLASMIN AND FIBRONECTIN-BINDING PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12708">
        <property type="entry name" value="Pect-lyase_RHGA_epim"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004879559" evidence="2">
        <location>
            <begin position="29"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="domain" description="Rhamnogalacturonase A/B/Epimerase-like pectate lyase" evidence="3">
        <location>
            <begin position="75"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="Rhamnogalacturonase A/B/Epimerase-like pectate lyase" evidence="3">
        <location>
            <begin position="618"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="433"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="482"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="552"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="552"/>
            <end position="563"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM34740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="985" mass="103935" checksum="18A28EC835AF3F7F" modified="2014-04-16" version="1">MAVLQTSIAIFVAHIILLLGLPASLVAAVPLSVPVSPVNNVLATTEKRSTSSYWVANVERQGVVPFATSTDYKIFRNVMDYGAKGDGSTDDTVAINKAISSGGRCGKGCDSSTTTPAIVYFPPGTYVVSKPIVQYYYTQIVGDAVELPVIKASAKFAGMAVIDADPYEDNGDNWFTNQNNFFRAIRNLVIDLTSVPEGSGAGIHWQVGQATSLQNIRFEMVKGGGDANKQQGIFMDNGSGGFMSDLTFNGGNYGMFLGNQQFTTRNLTFNGCQTAIFMNWNWAWTFKSVQINNCEVGLNMSTSPSNQTVGSVLLLDSKLTNTPTGIVTAWTQKSIPVGGGDLILDNVDFSGSKIAVAGINGNTILAGGSVVDNWVQGNTYTPSKTVTKRASESEPEVVTVIQTVTETIMACPASYGLSSTSLVSSDVPAPAKTASLESAPAPSPVPGVSTSSDSDRIAQTSSISVSNSVLSILGSSSEASEVSEPTSAAAPSSEAPATSVVSVGSSPSSVVSTKQSALPVVSTAVPVTSNVVPVTSIAASVTSTAASAKITSSSSAVSQATQSGSDSSTATCGASGAVASARTQSTLKTSSKPASLLNGGAIFERSKPLYEDVAASSFVSVKSAGAKGDGTTDDTAAIQKVFDSYKDGQVIYFDHGAYVITSTVKIPKDIKITGEIWPMLMAYGEKFADQENPVPVFQVGQKGDTGSVEMSDLIITTKGAAPGAILMEWNVAGSSQGSVGMWDVHFRIGGAAGTELQSDTCPKTPKQKTTPNKECMAAFMLLHITKTGSAYLENTWFWTADHELDLKDHNQINVYTGRGVLIESQNPVWLWGTSSEHHQLYNYQVSSAKNVFMGLIQSETPYYQSNPTALTPFTPQDSWNDPDFSNCTTNSCRKSWGLRVLGSSDVFIYGAGLYSFFENYAQSCLNSEDCQENMVEVDCSDVKLYGLSTKASVNMITSSDGKALVLEKPNKSNYCSTIALFEQSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W6QEK2</accession>
    <name>W6QEK2_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S04</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S04g000044</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QEK2"/>
    <dbReference type="STRING" id="1365484.W6QEK2"/>
    <dbReference type="OMA" id="SCPFVGQ"/>
    <dbReference type="OrthoDB" id="2316594at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="470"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM35163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="531" mass="57836" checksum="6681AB34836854C5" modified="2014-04-16" version="1">MESLQLSMNTLEIGEHMKLVKGDTGSSKTSPYENTRLDEELITAPLFSLSACQVLDTDRLYSDQALERDTFPQYGLLGLRNRSSNTPTQDDLVYANVSAPWSAFICGSQGSGKSHTLSCLLENALIASSPAGKLASPLAGLVIHYDNFTAFSSTQLCEAAYLYSSGIPVQVLVSPTNYLAMKKAYKTLAGGSKMLTVKPLYLPQKDLNIGMMKTLMGIGNKAEQPLYIEVVMKILRDMAIANQGKSGFNYSAFRNILQRETFLKGQIGPLNMRLEVLESFFEPGSVPGASPNKSKQHDVDDVWKFPPGSLTIVDLSCPFVGQEDACALFNIAVSLFLKNRRDTGRIIALDEAHKFMTSTSTEAADLTETLLSVVRQQRHLAARVLIATQEPTLSPSLLELCNVTIIHRFSSPAWFKAIKSHIAGAGIEKSDANAAASIFHKIVRLPTGEALVFCPTALLDIAKHNAKENEEASSVISSDRPVSEEGSSSADSTRAKDEPTLDRVVQLGTAYAHIRVRNRITVDGGRSVLER</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W6QFK4</accession>
    <name>W6QFK4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g002198</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QFK4"/>
    <dbReference type="STRING" id="1365484.W6QFK4"/>
    <dbReference type="OMA" id="RTIYRFP"/>
    <dbReference type="OrthoDB" id="5394108at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="365"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="82"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="213"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="271"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="289"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="396"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="411"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="429"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="463"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="482"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM28387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="627" mass="69924" checksum="FEF7BBC1C1D14234" modified="2014-04-16" version="1">MRLRSNHVLRPVSEYVPRRRRQTRSASAQAGTEAATETVPEAQSAPDLAEQYAAERPAPKRKPVKRAGRKKKAAPKGKKKAAPTAEPEAAAGTEADPQEDPVALIPSVEQPDTQPTRKRNRSSEDDLSPSKRHKLTLQTPPGFENRPRGSSRRTYADRARRREAERGGRIDRTIYRFPQLLAQQGEDARSGSLTPVASQASEETAPQGNRIVPLSSLPSALPPNQNQNQNRPNWRQWIFNSVTGIWGRGNAPQTAEVPQVVEPEHPTGNDSVATPSSAPPSSSVVASRNFESPTPSSRVTEPQTANSRLTARARAPQVGTRKKYSYDLDPQGFDPELLARMRAGMSDPADLEPVTSIEQVRALYDNESKKRKRETSPDVIPHPPGCSYGFDPDYFIYDDDDYDDDLPTGEQELQGTPTKHATVSDAPEEEHVSKRLRQDPPTRQATVSDAPEEEDVSNRVRQDTPTQQATVSNAPEEEHVSDNIQLESSNDQVTSEPIEYSAEELRKARQIAEARQTAEQYKPKTPSRLRAAHRFSSSCNSSIEVETVQRRKMRETSMATACPTGDLSQIEWPETETWIETFNWDDPNFEKYQRGSFVRTDLFPTEEAHFDACHKEFADLLAARRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>W6QFU6</accession>
    <name>W6QFU6_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial</fullName>
            <ecNumber evidence="4">2.1.1.201</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Ubiquinone biosynthesis methyltransferase COQ5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">coq5</name>
        <name evidence="4" type="synonym">COQ5</name>
        <name evidence="5" type="ORF">PROQFM164_S04g000136</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Methyltransferase required for the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 2-methoxy-6-(all-trans-polyprenyl)benzene-1,4-diol + S-adenosyl-L-methionine = a 5-methoxy-2-methyl-3-(all-trans-polyprenyl)benzene-1,4-diol + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:28286"/>
            <dbReference type="Rhea" id="RHEA-COMP:10858"/>
            <dbReference type="Rhea" id="RHEA-COMP:10859"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:84166"/>
            <dbReference type="ChEBI" id="CHEBI:84167"/>
            <dbReference type="EC" id="2.1.1.201"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Mitochondrion inner membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
            <orientation evidence="4">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.201" evidence="4"/>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QFU6"/>
    <dbReference type="STRING" id="1365484.W6QFU6"/>
    <dbReference type="OMA" id="MNDVMSM"/>
    <dbReference type="OrthoDB" id="6329284at2759"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031314">
        <property type="term" value="C:extrinsic component of mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008425">
        <property type="term" value="F:2-methoxy-6-polyprenyl-1,4-benzoquinol methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000133">
        <property type="entry name" value="2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01813">
        <property type="entry name" value="MenG_UbiE_methyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004033">
        <property type="entry name" value="UbiE/COQ5_MeTrFase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023576">
        <property type="entry name" value="UbiE/COQ5_MeTrFase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01934">
        <property type="entry name" value="MenG_MenH_UbiE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF24">
        <property type="entry name" value="2-METHOXY-6-POLYPRENYL-1,4-BENZOQUINOL METHYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01209">
        <property type="entry name" value="Ubie_methyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51608">
        <property type="entry name" value="SAM_MT_UBIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01183">
        <property type="entry name" value="UBIE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01184">
        <property type="entry name" value="UBIE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 4 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="binding site" evidence="4">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="179"/>
            <end position="180"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDM35255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="314" mass="35236" checksum="F65F33BEF5E25751" modified="2014-04-16" version="1">MSTMSTRSAWRALHYSAKRRAFQPSTPYRCFSCANRVQEQKPENDRMTHFGFTNVPEAEKEIRVGAVFSSVAASYDRMNDLMSLGIHRLWKDHFVRSLNPGSCLPALTADQRGWNILDIAGGTGDIAFRMLDHATNVNHDMETRVTISDINADMLAEGRKRSLDTPYYNTSRLDFVEANAEHMPHIPDASVDLYTVVFGIRNFTDKQAALNEAYRVLKPGGVFACMEFSKVDNPILDGIYKRWNFGAIPLIGQVVAGDRDSYQYLVESIERFPSQEEFRGMIQKAGFMIPGQGFENLTGGIAAIHKGIKPIVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W6QG62</accession>
    <name>W6QG62_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative methyltransferase BUD23</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">BUD23</name>
        <name evidence="11" type="ORF">PROQFM164_S03g001688</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class I-like SAM-binding methyltransferase superfamily. BUD23/WBSCR22 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QG62"/>
    <dbReference type="STRING" id="1365484.W6QG62"/>
    <dbReference type="OMA" id="WIQEKKE"/>
    <dbReference type="OrthoDB" id="2877at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016435">
        <property type="term" value="F:rRNA (guanine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070476">
        <property type="term" value="P:rRNA (guanine-N7)-methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000017">
        <property type="entry name" value="probable 18S rRNA (Guanine-N(7))-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039769">
        <property type="entry name" value="Bud23-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022238">
        <property type="entry name" value="Bud23_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12734:SF0">
        <property type="entry name" value="18S RRNA (GUANINE-N(7))-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12734">
        <property type="entry name" value="METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12589">
        <property type="entry name" value="WBS_methylT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 11" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="10">
        <location>
            <begin position="51"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="18S rRNA (guanine(1575)-N(7))-methyltransferase Bud23 C-terminal" evidence="9">
        <location>
            <begin position="218"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDM34961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="280" mass="30440" checksum="65360C6CA31C01BA" modified="2014-04-16" version="1">MSRPEDTLPPDLFYNDNESRKYTKSSRIRNIQASMTSRALELLDLKSPSFILDLGCGSGLSGEMLSEVEPEDGGPHTWVGMDISPSMLDVALQREVEGDLFLADIGQGVPFRPGTFDAAISISAIQWLCNAETSDVTAEGRLRRFFEGLYASLRRGGRAVCQFYPKNDVQRSMISGAAIKAGFGAGILEDDPGTKSSKLYLVLTVGGGGLPGDITGVVNGMDDVNILDARRKATEINNARGPPRKGDKAWIMNKKEQMAKKGKVVKASSKYTGRKRRIAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2024-10-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W6QGI5</accession>
    <name>W6QGI5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S02g003426</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM33274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QGI5"/>
    <dbReference type="STRING" id="1365484.W6QGI5"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004880209" evidence="1">
        <location>
            <begin position="20"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM33274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="107" mass="11439" checksum="BFFD1E2AAB56D31C" modified="2014-04-16" version="1">MTLIALTQALVLAVTLVNASPVGLKSRTDADAATAYTADKRWDADAATAYTADKRWDTDAATAYTADKKRSGADVATAYTADKRSEVAEPVYRRWDADAATAYTADK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W6QGS4</accession>
    <name>W6QGS4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type DNA-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PROQFM164_S04g000047</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QGS4"/>
    <dbReference type="STRING" id="1365484.W6QGS4"/>
    <dbReference type="OMA" id="WAVTADP"/>
    <dbReference type="OrthoDB" id="4314040at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053178">
        <property type="entry name" value="Osmoadaptation_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38111:SF11">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38111">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="9"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDM35166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="466" mass="51802" checksum="F6033A544A1C0E25" modified="2014-04-16" version="1">MPGVPTGRACDACRKQKKKCDEKQPECGRCLRLKVSCVGSGQQRFKFKEQQFSPKSNRSGQMTLTSRSKSTEKVIFSFEIPRACPGNSMMSLTNSFIGAIKRSTDLRYNLWWAFGTFLEDIPRRLGSNEALDHAVDAVTTAHAGFCTGRSVSAETLAKYSYALKTLRVYLDHPVQASASSTLCAVMILLVCQTFIGNNGQMISGHAQGAASILHARKNFGPRDDFERKLFLSLRGSVLFEGLYNDAIDLSSEEWDSLVKNDFDQDQPEGQILRCLARAPVLMRRGKQAIRDGEDLMLLTMEVRPIYEKCKLILGELQVRTVEFEKSGLTMTETFMGRILRAHYLRTHGIGLAITTFFNCILQALDPSDYTCMVESKSLVKDTLEHAQKSNVYRPVGAGYVIMCLSAAWAVTADPELRSMVEAALIDYHGDFVTRDVVNIPKELEQASENLRLGLTAQANAIFVPSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W6QHH8</accession>
    <name>W6QHH8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Extracellular membrane protein, CFEM domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PROQFM164_S04g000766</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RBT5 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QHH8"/>
    <dbReference type="STRING" id="1365484.W6QHH8"/>
    <dbReference type="OMA" id="TEYSCTA"/>
    <dbReference type="OrthoDB" id="5431405at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008427">
        <property type="entry name" value="Extracellular_membr_CFEM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05730">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012745768" evidence="10">
        <location>
            <begin position="16"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="domain" description="CFEM" evidence="11">
        <location>
            <begin position="427"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="591"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="591"/>
            <end position="603"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDM35885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="649" mass="68637" checksum="77FA02D19E4E90B5" modified="2014-04-16" version="1">MKGIALLSLFSAALAHPAGLWWGTDVCYTSPENTDNQCSDVQQKGFDLSELANGDNWSFEGFHFVGLEPKNGCHGSSYGGTCLGGKLSRDDDWTIKISAADAPFSIRNFHLSTSRNTDIFIIYEMPDGSSCHHVTSSSYKGTDVGNDQCGGAVSVEFTLPEESKFGDCDLEIHSIDFDCSTGSKPPVPVIEPPHSHSHYHSEPSPSSTVSLPPFHWTSSVPQVPTTSSSFQHWTTSTVWTTEEITITQCPPTVTNCPAHSTVLITSTYPLSTTVCPSTPVQTVPSDPPKSTTSLPPFHWTSSVPDVPTTSHSWHHMTTSTVWTTEEIIVTKWASTATECPSSSVLTTSTHPLSSTPCSSTPVQTFSSTSCASSTPVQTSTSTSCTSSTPVQTPSTSCTTSHFVHSHTTPISTPTPIAPSPPAVTAPCPNVVPKCLNTWLSIPKCDSNSDVGCFCPSTEFTDKVSGCIRAWSTSQTEEDSALAYFAGICAPFVPENPAIVDIATTCTSPLVPKTTAGPHITGNTRTFVETVATTVPQAPCTTISWASHTATVPLVEFSTVTCSSTTSVNLVVVTTTSTPSKTHHYAHASSSKMTTSCKPTSSLPPTAPGITVSKPSGSEPTETVAYGNVGSKLPLCSLWAFGISLLALFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W6QIC6</accession>
    <name>W6QIC6_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Small-subunit processome, Utp12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PROQFM164_S05g000406</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UTP5 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QIC6"/>
    <dbReference type="STRING" id="1365484.W6QIC6"/>
    <dbReference type="OMA" id="CEHAVNP"/>
    <dbReference type="OrthoDB" id="30195at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007148">
        <property type="entry name" value="SSU_processome_Utp12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052414">
        <property type="entry name" value="U3_snoRNA-assoc_WDR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44267">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44267:SF1">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04003">
        <property type="entry name" value="Utp12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Small-subunit processome Utp12" evidence="5">
        <location>
            <begin position="568"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="406"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="699"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="411"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="424"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="467"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="498"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="699"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="709"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="723"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="767"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="793"/>
            <end position="802"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDM36573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="829" mass="89001" checksum="A56C4625D6F84FA5" modified="2014-04-16" version="1">MGKKTTRPSTKVASAATSPASGMTYAGSKSSILRAAFSPSEYQLALFASVIQGLDGQHIRIHDTQTGRLQCEHALGPKETVTSLDWGYYGGSGKGRDQSKKKRKRGSDVNGAVDGLDQGDIVVAFGTNTSDIRMYSPSEDKVVGTLTGAHDKGIKDFKFTADRPAQEAWSIGGDNKLVQWDLRTGQSTQTIHLPSSSVFTALSRPVPSNPPLICASQTPYLIDTEKADEPVQFPAMRNPIHTVISSSSESAGVGAFLASDGDRFINVFDVASQKLVRNLVADQEVSSITLQTDGATTPEKQVLAAVTADGSIELFTKPFVQPQSAPSASAKASRKQMTQKANATLKITNTESSNACVPVAAISFQGPNLVVAYTEGGVIPVFERVKFLDEKTDELSFTGTKTVVKTKSGSALSSVTTNGVKSAGETRVDESRMNVEQGNLVDDDVEMEDSRQDASDSGSEEDSDDDDNKKSKASTEKKTKPTKQVAANEDVEMQNASDSEEEEEEEGAEPSFGELLRANAGQEVDVEAELDDDVLLGALVPGKPQAVVQQIPTGVSLATVLTQSLKTNDNGMLESCFHTGDTSIIRTTIQRLDSSLAATLLQKLAERLASRPGRYGHLLVWVQWTCVAHGGALAGHPDLLKRMTSLYKVMDQRSATLPSLLLLKGKLDMLDAQLGLRQSIRGGDEGMDSEDEDNVIYVEGQDDLEDSETEAKTPRKSIRDQAYDEDESMMNGVDESEDDEDDGSDDEDDDEEPILDIEAAESVGSSDAEESLEENEDEDEDEDSDGSMVDFIADTEDDESDDAAQQQPPPSKKSKSSASIGKKSKGGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W6QIY9</accession>
    <name>W6QIY9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Vacuolar protein sorting-associated protein 62</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S05g000203</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QIY9"/>
    <dbReference type="STRING" id="1365484.W6QIY9"/>
    <dbReference type="OMA" id="FWPGDIA"/>
    <dbReference type="OrthoDB" id="188042at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009291">
        <property type="entry name" value="Vps62"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48172">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48172:SF2">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING PROTEIN 62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06101">
        <property type="entry name" value="Vps62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004879641" evidence="2">
        <location>
            <begin position="24"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="276"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="285"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM36370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="588" mass="66713" checksum="8A4CC43CF197ED60" modified="2014-04-16" version="1">MGSFLRIPTALLCALLVSTFVISRPTIVPGECPPAAALSLESHCIEPLASTGIPELAVYEHTPHSSSTLTVYVDSLQQMTRKAKATIGVLSTLIAYVSINSLIHILRPGAFVWSTEDEEERSWIASSRSWFDRKSCRWLGVCGAAHIQTVHGAFGHRDPAQWVKAQDAEPEAPWRSFWLSGASDSEWDAEERARRQIPDYVFHYAPLVHLYSGEQFWPGDIAEHLYHTTPTLNYTPIQAQWDHPTLADLDELNQWGPRHVFLTSNDDAQTRPHWLEGDKNIPQADGDDKEESWADWDGRVDGDIPGDTEEDRAKWYDYYQLQQEAAESDADEHSEAQEILREEIRRRYGGEEIHQDAAGGRSDAPAILVVMDKGNGIVDAFWFYFYSFNLGNTVANVRFGNHVGDWEHCLVRFHNGNPKALFFSAHQGGEAYSYEAVEKIGQRPVIYSAEGSHAMYATAGVHDYLLPWGMLHDVTDRGPLWDPLLNSQAYTYDFDNEHLRASTFTPSAPTEWFHYRGHWGDKFYPLSDPRQYRFAGQYHFVNGPIGPKFKHLNRHKVCQGPDRSPCVVKNYVEQGKRPKRWGASRPGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2024-10-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>W6QJ68</accession>
    <name>W6QJ68_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S01g003444</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QJ68"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM29632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="92" mass="10780" checksum="0286DBD4C05D24E5" modified="2014-04-16" version="1">MNDRYDTWEPVVGSSVTEERWRRGKRRPIPSISDLLFPEICFMYETYSNVRRAFETQPMLSVTVMIGYLTFQTRPVLRKQSNPASTGLDQCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W6QJN1</accession>
    <name>W6QJN1_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SET domain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S05g000463</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QJN1"/>
    <dbReference type="STRING" id="1365484.W6QJN1"/>
    <dbReference type="OMA" id="YVFNIFY"/>
    <dbReference type="OrthoDB" id="42889at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1410.10">
        <property type="entry name" value="set domain protein methyltransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050600">
        <property type="entry name" value="SETD3_SETD6_MTase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271:SF135">
        <property type="entry name" value="SET DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_4G11040)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271">
        <property type="entry name" value="UNCHARACTERIZED PUTATIVE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM36630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="676" mass="76196" checksum="39246DA797B24516" modified="2014-04-16" version="1">MAASSEQVDPSLKAHTELVNWFIQHGGTVDKSVRIAQDASRGVHLQVRADWPEAIRKETRVINTPISVSMSWYNAIGYESPRGSFPKHGVDFPRTWIDDVGPEETFAFFLMGQYLRGPDSFWYPYLRTLPQPGQLTTPLFFGEEDVDWIQGTGIPEAAVERIKIWEQKYDSGYLQLDAIEFPDCEQYTWELYLWASTIITSRAFSSKVLSGAVEPGDLPEDGVSALLPLIDLPNHRPMAKVEWRAGDEDIGLLVLEDHSAGQEISNNYGPRNNEQLLINYGFCIAGNPTDYRIVHLGVKPDSPLGEAKARQLELFPQVAKNIEDHYYIFNTFYPLLAPETTMEHSIFSPALFNALTVMESNKRERKSLEITESCIRILPGYGNNHSIYAALAQISFELMAHAANLKASAEHLPLQPTTLNQIHSQIYRNGQITLDQAALVIATWTIARGREHKRGESWEDTKVLLHEVMARVPAGLLSDEVMSRIRVRILERPSLITKNGELFRLGELFSLLPAEMQEPAQTCFQHALGEASQAVPSISTDPQTLFATVICLLVATYNSPEARSRLSSRLNRWFTFLLEQYPLPSRSIETGVDEASETLRQFQRYTTAAQPSSWAPGDGVNWLTEDSGWLDSEWLQWSWTVAGSEMVMIPLDPFEILKMEGSLSMLKQACLYVPQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W6QK01</accession>
    <name>W6QK01_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S03</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S03g001278</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QK01"/>
    <dbReference type="STRING" id="1365484.W6QK01"/>
    <dbReference type="OrthoDB" id="5979581at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM34554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="55" mass="6575" checksum="CDE8249E33FC6383" modified="2014-04-16" version="1">MPSFEPNERDALFSISRPMLSFRPENRPSAQQVLESEWMVKWALPEYEKIRNAQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>W6QK70</accession>
    <name>W6QK70_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 15">NADPH:adrenodoxin oxidoreductase, mitochondrial</fullName>
            <ecNumber evidence="4 15">1.18.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">FDXR</name>
        <name evidence="19" type="ORF">PROQFM164_S06g000174</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14 15">
            <text>2 reduced [adrenodoxin] + NADP(+) + H(+) = 2 oxidized [adrenodoxin] + NADPH</text>
            <dbReference type="Rhea" id="RHEA:42312"/>
            <dbReference type="Rhea" id="RHEA-COMP:9998"/>
            <dbReference type="Rhea" id="RHEA-COMP:9999"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.18.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 15 16">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 15">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the ferredoxin--NADP reductase type 1 family.</text>
    </comment>
    <dbReference type="EC" id="1.18.1.6" evidence="4 15"/>
    <dbReference type="EMBL" id="HG792020">
        <property type="protein sequence ID" value="CDM37213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QK70"/>
    <dbReference type="STRING" id="1365484.W6QK70"/>
    <dbReference type="OMA" id="RFNFIGN"/>
    <dbReference type="OrthoDB" id="333024at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000036">
        <property type="entry name" value="NADPH:adrenodoxin oxidoreductase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055275">
        <property type="entry name" value="Ferredox_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021163">
        <property type="entry name" value="Ferredox_Rdtase_adrenod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48467">
        <property type="entry name" value="GLUTAMATE SYNTHASE 1 [NADH], CHLOROPLASTIC-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48467:SF1">
        <property type="entry name" value="GLUTAMATE SYNTHASE 1 [NADH], CHLOROPLASTIC-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000362">
        <property type="entry name" value="FNR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00419">
        <property type="entry name" value="ADXRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51971">
        <property type="entry name" value="Nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8 15 16" id="KW-0274">FAD</keyword>
    <keyword evidence="7 15" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="13 15" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9 15 17" id="KW-0521">NADP</keyword>
    <keyword evidence="12 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="18">
        <location>
            <begin position="48"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <begin position="194"/>
            <end position="197"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <begin position="238"/>
            <end position="239"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="433"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="440"/>
            <end position="442"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="440"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR000362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR000362-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR000362-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CDM37213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="533" mass="58598" checksum="4FF4362E5AF4492F" modified="2014-04-16" version="1">MQLKQAFVCAQCTVRLNRRPLLRCQSFVSQFISKRSNSHVAQSDRPVRVAIVGSGPAGFYAAYRLLAKQEDAIVDMYEKLPVPFGLARYGVAPDHPEVKNCEDKFTEVAESTRFNFVGNVDIGHDLPLAALKPHYDAIIFAYGATEDKELGIPGEKALHSVHSARAFVGWYNGLPEHRDLDPDLSGENAVIVGQGNVALDVARILLTDVETLQKTDIADYAVEKLATSRIKRVRVVGRRGPLQASFTIKEIREMLQLPDVSFDPIPDDIFPPEEVVSALPRAQKRLMQLLAKGSANDPLKSSKSWSLDFLLAPDSLHWSPDYPYHLSHVKFSRNELDPSDPYSPSSKVFPKHLSSGKRAQVNLPASVFFRSVGYKSLPLPGLEDLGIDFDTRRGIIPNDGFGRVTSLSNKGQPEALPAGSLVSHLPGLYCAGWVKRGPTGVIASTMTDAFTTADTVVQDLSKSAGSTSLLNAPDHGSGLGWDGVKIEAQRRGLRPTSWTDWQRIDAAERESGQRKGKPRDKLGRVEEMLKVLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W6QKA4</accession>
    <name>W6QKA4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S05g000673</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QKA4"/>
    <dbReference type="OMA" id="LASEMWD"/>
    <dbReference type="OrthoDB" id="3796275at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM36840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="244" mass="27532" checksum="8859FDD0575A5DA5" modified="2014-04-16" version="1">MITGRTLLRKPLPPLDIGPYHTTSSALHEGRFLGTLHNWPDFFQDVKQFENNQDWSPSLLGWSLQSRRVDAEFVAIGDEHGLQGRFQQSVGQVVGSVLNAQNIAVKFGDSKSANIASVYSGYTLTPDVALISTDPVDIDQIQAMWELKSPWVNEHKFKKYPTAQRKAKLFAQLIGYMLDLQLRYGFISTYDSTVFLRQVFKNGEWVVEYSPVVEASFDGSDTMGNEPPSPRQCFAYLSSLKKMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W6QKC7</accession>
    <name>W6QKC7_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S05g000713</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QKC7"/>
    <dbReference type="STRING" id="1365484.W6QKC7"/>
    <dbReference type="OMA" id="TPQDWVE"/>
    <dbReference type="OrthoDB" id="10251744at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="322"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="357"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="430"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="632"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="763"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="851"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="936"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="210"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="13"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="91"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="150"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="322"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="372"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="440"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="764"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="892"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="945"/>
            <end position="956"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM36880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="956" mass="106145" checksum="BAB1BA1EFAD67DEA" modified="2014-04-16" version="1">MPAVIMDEKTQRRSSAAGQLAPSNTRSPVYHPSTAPKRSVSSKDHSSNLSDRPQHPSLSRVKGRSNMFTPPRMSPEVSWLGDQSPVQRGARTPVRSSTSETPEPSTPTLVNPASALLQDLLKEERAHRSSRGTISEDFKENAPLTPENTRTQEEPTSEKARKANDVFSAGQRKPKEMGMREMDQYVSKMNKLNFDLKLEVFHRTQQLAMYEKKLERMAEMEEQLAHMDDLMAEVEELRTTEKENQTLRESNEQLRNDLDKRDLAVTEAVELICQLESKLDLLENGRGSRLSMSRPMTADGSEALAKAQAMIEIPERTSSKRNASVLNVAQNQSSSELRRLSKAPSFLRADNKSTATLRSLYAPEEETQSRSARTELSKSESFHTNNEMMEPESPRLSVLSECSELNAFDTPMMWQEFDQLEIPVRRPSSVAGSLDSYVTPREREESRKDKIDRWMQSREDVSETIINRRRNRVSSDATKASVASFSPDLYASKPRGRGRLDGSLFGGIHLPPTPDTMSTAYAIGANRSNGSDGSIAARKGSQTEDLFFPGRRLNRPRSAGEMACPYSYGSDIDDSMQNNCNDTPRLGVADESRTILPSFNTVSSKASALLGPGSPDNPVIETFGDLYHASANEGSTQTIKRVRSPAKAKTPEPHSDSDSSPPLTPQDWVAAAKHPRSRRPRPRDTRHEIQPTDLSPGTVISPAFEDDSSLASGSSELEITGIPTLDMSTLDILARNLEPTQPGPKVEAKHEHRRRLSFLPPFFNRSSSNARQLQGSPVLNDFEDDFDDGAPSPVIPKTRTTGGAPRRPASQIITAPTELYPSNPPIHIEEPPAAFRRGFPQSATMSTLADHGTETLARPSSSQGPEHKRRSSLGIFGWMKSKRSDSGPGTEKFTDSTSKENRASSRLAYETTHGLGIPHGNTDSMETHVRHHSEMGIQYDDYARRPRYMGRRTRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>W6QLD1</accession>
    <name>W6QLD1_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 17">Homoaconitase, mitochondrial</fullName>
            <ecNumber evidence="5 17">4.2.1.36</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16 17">Homoaconitate hydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="primary">lysA</name>
        <name evidence="21" type="ORF">PROQFM164_S02g000506</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 17">Catalyzes the reversible hydration of cis-homoaconitate to (2R,3S)-homoisocitrate, a step in the alpha-aminoadipate pathway for lysine biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 17">
            <text>(2R,3S)-homoisocitrate = cis-homoaconitate + H2O</text>
            <dbReference type="Rhea" id="RHEA:15485"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15404"/>
            <dbReference type="ChEBI" id="CHEBI:58174"/>
            <dbReference type="EC" id="4.2.1.36"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="17">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 17">Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-alpha-aminoadipate from 2-oxoglutarate: step 3/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 17">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 17">Belongs to the aconitase/IPM isomerase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.36" evidence="5 17"/>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QLD1"/>
    <dbReference type="STRING" id="1365484.W6QLD1"/>
    <dbReference type="OMA" id="LCDADNI"/>
    <dbReference type="OrthoDB" id="10262323at2759"/>
    <dbReference type="UniPathway" id="UPA00033">
        <property type="reaction ID" value="UER01027"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004409">
        <property type="term" value="F:homoaconitate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01674">
        <property type="entry name" value="Homoaconitase_Swivel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000013">
        <property type="entry name" value="Homoaconitase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1060.10">
        <property type="entry name" value="Aconitase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="entry name" value="Aconitase, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="entry name" value="Aconitase, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018136">
        <property type="entry name" value="Aconitase_4Fe-4S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015932">
        <property type="entry name" value="Aconitase_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004418">
        <property type="entry name" value="Homoaconitase_mito"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039386">
        <property type="entry name" value="Homoaconitase_swivel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050067">
        <property type="entry name" value="IPM_dehydratase_rel_enz"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00139">
        <property type="entry name" value="h_aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43822:SF2">
        <property type="entry name" value="HOMOACONITASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43822">
        <property type="entry name" value="HOMOACONITASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="Aconitase iron-sulfur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00450">
        <property type="entry name" value="ACONITASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01244">
        <property type="entry name" value="ACONITASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 17" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10 17" id="KW-0408">Iron</keyword>
    <keyword evidence="11 17" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="14 17" id="KW-0456">Lyase</keyword>
    <keyword evidence="13 17" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="8 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 17" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 17" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha" evidence="19">
        <location>
            <begin position="108"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="domain" description="Aconitase A/isopropylmalate dehydratase small subunit swivel" evidence="20">
        <location>
            <begin position="574"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="64"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00021560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00029338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00032706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU362038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="CDM30357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="786" mass="84836" checksum="F876D690C4DC5E0A" modified="2014-04-16" version="1">MSPCSMLLKRVARPPATMMCRPVRPRWTPSFGVPSRTIHHPLRSVSRSLSSRSLSTTAFTQAEGFHSQQENASVPFSETPTERRTPQTLTEKIVQRYAVGLPEGKLVRSGDYISLAPGYCMTHDNTWPVALKFMSMGATKINRPEQIVMTLDHDVQNTSAANLKKYEQIETFAGQHGIDFYPAGRGIGHQIMVEEGYAWPGSMAVASDSHSNHYGGVGCLGTAVVRTDAASIWATSRTWWQIPPVARVTFTGTLPVGVTGKDVIVALCGLFNSDVLNHAIEFTGSEETMESLLVDSRLTIANMTTEWGALTGLFPIDQTLKRWLRYKATEAAMSEDRTTRNRITHERIDELFANPLTADPDAQYAKQLYLNLSTLSPYVSGPNSVKIATPLNELVQKDIKINRAYIVSCTNSRASDLAAAAKVFKDAAKANPGTTPKIADGVKLYIAAASAPEQEAAESTGDWQALIDAGAQPLPAGCGPCIGLGTGLLEPGEVGISASNRNFKGRMGSRDALAYLASPEVVAASALNGVISGPGSYKVPENWSGVEHGFGTGSEPTTENELTNILQQMESLIDRVESAADESKPATEILPGFPERISGEILFLDADNLDTDSIYPGKLTYQDNVSKDDMAAACMQNYDPTFKGIAKPNDILVAGFNFGCGSSREQAATAILAKQIPLVVAGSFGNIFSRNSINNALMGLEVPRLVERLRASFVQPSSGDVAGRQLTRRTGWTLTWDVKRSVVEVKEGETGETWTEQVGELPANVQEIIAEGGLEAWVKGKVAESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W6QLK0</accession>
    <name>W6QLK0_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Rhodopsin, archaeal/bacterial/fungal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PROQFM164_S07g000061</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the archaeal/bacterial/fungal opsin family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792021">
        <property type="protein sequence ID" value="CDM37713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QLK0"/>
    <dbReference type="OMA" id="GHWNIDP"/>
    <dbReference type="OrthoDB" id="536545at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009881">
        <property type="term" value="F:photoreceptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007602">
        <property type="term" value="P:phototransduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15239">
        <property type="entry name" value="7tm_YRO2_fungal-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000160">
        <property type="entry name" value="Related to Opsin-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001425">
        <property type="entry name" value="Arc/bac/fun_rhodopsins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043476">
        <property type="entry name" value="Yro2-like_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28286">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28286:SF1">
        <property type="entry name" value="30 KDA HEAT SHOCK PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01036">
        <property type="entry name" value="Bac_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00251">
        <property type="entry name" value="BACTRLOPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01021">
        <property type="entry name" value="Bac_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0157">Chromophore</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0600">Photoreceptor protein</keyword>
    <keyword evidence="3" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0681">Retinal protein</keyword>
    <keyword evidence="4" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="64"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="162"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="196"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="276"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="276"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDM37713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="298" mass="34024" checksum="F60B680E4991351D" modified="2014-04-16" version="1">MESLSAFVKRNDALKINPPSAAIHITSRGSDWLWTVFAINYFSLVVFLGLLFRTPRRDRIFHYISILTVTLSGICYFTMASDIGSIAVAPEWVRSSHEVAGATRQVFWIRYLDWFTTMPLIIFNVLLTAGVYWHTILYTVMMTIIFVILFFVGAIVPDTYRWGYYTIGTVALFLALENIVWAGITHANALGGNIKKFYTFLGPYVFILWILYPICWACSEGGNVIAPDSEQIFYGILDVFSKPILCWIILFAHTRIDITQLDLRLYDRGDVERNTPRFNEKEEERGVAAANNDPAQNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W6QMB2</accession>
    <name>W6QMB2_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PROQFM164_S06g000532</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="HG792020">
        <property type="protein sequence ID" value="CDM37570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QMB2"/>
    <dbReference type="STRING" id="1365484.W6QMB2"/>
    <dbReference type="OrthoDB" id="1937899at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050684">
        <property type="term" value="P:regulation of mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051334">
        <property type="entry name" value="SRPK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634:SF9">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="198"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="198"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDM37570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="222" mass="24974" checksum="22F5C0AA0E2C0E7D" modified="2014-04-16" version="1">MANVPELRYVVVGLEQKGFGDELKRFIGLVAEHTRSELEPQKLFDVLVCLGTEIQNVKSAVPKPDGIFEYVSKSLSLHPVKQTTEEADFHSTGGFHPVSLGDTFNSGTYKVVRKLGYGQYSTVWLARESKVQSYSVFNALFQTWHITPTNILLELENPEQTIEKYLSEVPIRVNNKYSITRPLREVIRTPLISEIPSCSDNHPSDTIQSPALRAPEFTIGTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W6QMQ9</accession>
    <name>W6QMQ9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S04</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S04g000335</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QMQ9"/>
    <dbReference type="STRING" id="1365484.W6QMQ9"/>
    <dbReference type="OrthoDB" id="4362445at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM35454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="95" mass="10684" checksum="917FB71C4ABB7B01" modified="2014-04-16" version="1">MLILEGKAPKVVHEFEKVIDKMPAKFQIKITDIFESKASAGVFVRMTWEVYARLLSTVDMKPLLPVVGPSRIRAQLLLEGTYPSFGYLVSLADDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>W6QNI4</accession>
    <name>W6QNI4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Probable transposable element</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PROQFM164_S04g000560</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QNI4"/>
    <dbReference type="STRING" id="1365484.W6QNI4"/>
    <dbReference type="OMA" id="NTSKWSH"/>
    <dbReference type="OrthoDB" id="20839at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15492">
        <property type="entry name" value="PHD_BRPF_JADE_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000008">
        <property type="entry name" value="Bromodomain containing 1, isoform CRA_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000007">
        <property type="entry name" value="Bromodomain containing 1, isoform CRA_b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019542">
        <property type="entry name" value="Enhancer_polycomb-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034732">
        <property type="entry name" value="EPHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050701">
        <property type="entry name" value="Histone_Mod_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13793:SF107">
        <property type="entry name" value="BROMODOMAIN-CONTAINING PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13793">
        <property type="entry name" value="PHD FINGER PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10513">
        <property type="entry name" value="EPL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13831">
        <property type="entry name" value="PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13832">
        <property type="entry name" value="zf-HC5HC2H_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51805">
        <property type="entry name" value="EPHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="9">
        <location>
            <begin position="413"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="10">
        <location>
            <begin position="467"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="376"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="920"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1057"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="21"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="60"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="97"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1065"/>
            <end position="1078"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDM35679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="1087" mass="121463" checksum="32E88283DF53A042" modified="2014-04-16" version="1">MAPTARHSISGRSSRSKPRSSLKSSNSRSVDSPDGPPSKKRKYVPGGPGGGGRFIDFDAEAAVVAATAPETSKRTTPRRHSASARSRPPHEMEQPFLAPPPPPPIIPTTPPSMSRPRRDKNQARGRFTSSTAAALALQQGDGYKPREERGWEEFHPDLDIDGKIAVFTSEEVDAPDTSGPILSLESLAGATISDLSGSPVIISGEMASPIPIKRRPGRPPRRPEAILNALLAQQGQKIIPPPGPNPREKLTLPKPSFRLRDPFTFYEKKGVGHQNYVDRTMANVGYQESDLFLRHDRRFIRMTEGTQEDDLDVIQPAMTDGDVNTTIGRVEYDMDEQDEKWLEEYNAKRREDQLEPIKPAVFEITMTKIEREWHALEKRIPKPNPKPPQTGRLRSSSAAAVNGETAGPGEEQDSKCAICDDGDCENSNAIVFCDGCDLAVHQECYGVPFIPEGQWLCRKCQLLGRGSTNCIFCPNTEGAFKQTTSSKWAHLLCSFWIPEVSIGNPSLMEPVTDVEKVPRSRWKLNCYICKQRMGASIQCSNKNCFVAFHVSCARRAQLYLKMKIGHGLMDSHLLKAFCDKHVPSDWRLEHGTDAATADAIEYYRNTMQGRRWGDSQAAALSMGPAHPNDGAEEDRTLTPRLTLTVGGNKRKRVPRTIWKLPSGAPVIPQVVLNSVIASLGRFTVRQRKQYAEDASKYWTLKREARRGAALLKRLQLQLETFSSMEMTRRDYVAMGVPGHRRLERRIEFGERLYKDLDRLRMLCDEVKKREREKLKDAEMLRNIVDLVYFPTFPLLWPILEKAQLLDGKGVFAPGLMSIRQRLNERFYPSVAAFSSDLASLFTSEIGVEPAGDTAELQAQISGRAPELSLEQREKRKLAKRIIKVIQPSLEDAIRKESELNRKPFEKELKELDMILDHSVMSRSGDSVEPEGDTELSGHPDAMEGVEETLPTTEAPSEAQPTAGEQHPEASGAEELPPAEDPIKSVNAYYRHPTPVLTEQDQQLPLALGGIQWYMQPFDPVGTTVHEERWTGRDVMRGMSEELSELDEDELEGLKDLVDDGDLKGQTPSTPAASQQNTRRTLRLRGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2024-10-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W6QNN3</accession>
    <name>W6QNN3_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S08g000066</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792022">
        <property type="protein sequence ID" value="CDM38015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QNN3"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM38015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="94" mass="10319" checksum="62256E26E12156ED" modified="2014-04-16" version="1">MTRDIPLEPRTNSSNEAHQHLHSNKYAQQHKASTSIDTVTIEVAGCINAARPVFPLAGPAVEGFLLVEPCWVIGGRRVYYEQYAGQGSYKTCNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W6QPW4</accession>
    <name>W6QPW4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pseudouridine synthase, TruD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PROQFM164_S08g000087</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the pseudouridine synthase TruD family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792022">
        <property type="protein sequence ID" value="CDM38036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QPW4"/>
    <dbReference type="STRING" id="1365484.W6QPW4"/>
    <dbReference type="OMA" id="WINYFGH"/>
    <dbReference type="OrthoDB" id="447290at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
        <property type="term" value="P:pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02576">
        <property type="entry name" value="PseudoU_synth_ScPUS7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2350.20:FF:000009">
        <property type="entry name" value="Pseudouridine synthase TruD/Pus7, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2350.20:FF:000007">
        <property type="entry name" value="PUS7p Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.20">
        <property type="entry name" value="TruD, catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001656">
        <property type="entry name" value="PsdUridine_synth_TruD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011760">
        <property type="entry name" value="PsdUridine_synth_TruD_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042214">
        <property type="entry name" value="TruD_catalytic"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00094">
        <property type="entry name" value="tRNA_TruD_broad"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13326:SF21">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE PUS7L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13326">
        <property type="entry name" value="TRNA PSEUDOURIDINE SYNTHASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01142">
        <property type="entry name" value="TruD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037016">
        <property type="entry name" value="Pseudouridin_synth_euk_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50984">
        <property type="entry name" value="TRUD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TRUD" evidence="4">
        <location>
            <begin position="375"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDM38036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="730" mass="80812" checksum="A635CB937154903F" modified="2014-04-16" version="1">MEKPDIVESPRKRQKTEDVGSTEVAIAVNGATDTPSTAVSDAQALKEVEVGITEFVSNTEGFSGILKKRYTDFMVNEIMTTGEVVHLRSIHTITEPDNSVNTVTERTPASTVPEVQAQAAEQTPAKEAETPAQIKVSEEDHTLLEEYFGAQNAAEIIALHKFAMAKPKGRPSEFGSVTFAVSDRDLRTKIHQAIRRIFNSQLESTTDADGNMSITAANNRFQRGATAGRANARVQGQRTNWEELGGPYLHFTIYKENKDTMEVINYIARSLRMNAKALQFAGTKDRRGVTVQRACAVRVRLARLVEVNSELRNARIGDFQYRKHGLDLGDLQGNEFVITLRDVEIPGVSMSDPQAAIAKASEVVGTSLKNLYQRGYFNYYGLQRFGTFATRTDTVGVKMLQGDFKGACDAILQYAPASLQAAMEGNMSTANISNDDKDRAMAINIFQTGGSVADALLKMPRKFSAENSLIRHLGRSSKDYLGALQSIPRTLRLMYVHAYQSLVWNFAASERWRLYGDRVVEGDLVIIQEHRDKESASAVEAAETVDADGEIIVVPQGENSAVAAEDMFMRARALSAEEAASGKYTIFDLVLPQPGYDIIYPENEMKEFYRRFMESEQGGGLDPSNMRRKWKDISLSGGYRKIFSRMLGANYSFDIKLYSKDDEQFVKTDLQNLQPANENTDTAMADETAADKLAVVLKFQLGSSQYATMALRELTHGKATAHKAEFGGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W6QR64</accession>
    <name>W6QR64_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S12g000070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792026">
        <property type="protein sequence ID" value="CDM38461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QR64"/>
    <dbReference type="STRING" id="1365484.W6QR64"/>
    <dbReference type="OrthoDB" id="4525782at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM38461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="52" mass="6132" checksum="D15B39D09E94500F" modified="2014-04-16" version="1">MTSVFFNRGLEEAGLDPSRVGVDKLRCFLEEILDTHIQRELPKVRDDIRRLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W6QS48</accession>
    <name>W6QS48_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein bcn92</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">bcn92</name>
        <name evidence="3" type="ORF">PROQFM164_S02g002478</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I LYR family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QS48"/>
    <dbReference type="STRING" id="1365484.W6QS48"/>
    <dbReference type="OMA" id="YTTDKLV"/>
    <dbReference type="OrthoDB" id="275715at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990221">
        <property type="term" value="C:L-cysteine desulfurase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20264">
        <property type="entry name" value="Complex1_LYR_LYRM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008011">
        <property type="entry name" value="Complex1_LYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045297">
        <property type="entry name" value="Complex1_LYR_LYRM4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051522">
        <property type="entry name" value="ISC_assembly_LYR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13166:SF7">
        <property type="entry name" value="LYR MOTIF-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13166">
        <property type="entry name" value="PROTEIN C6ORF149"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05347">
        <property type="entry name" value="Complex1_LYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Complex 1 LYR protein" evidence="2">
        <location>
            <begin position="13"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM32327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="112" mass="13211" checksum="B98A9BBD9B8604FF" modified="2014-04-16" version="1">MSVASLHRETAFQARSLFRSLLRYSGQFSNYNFREFARRKTRDSFREHQNATEERQIQELIQEGLKSLRMLKRQTIISQFYQLDKLVVEGQKTGKETGNHGGIVRQKDTGWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W6QS96</accession>
    <name>W6QS96_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RNA polymerase II-associated protein 1, C-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PROQFM164_S02g002508</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RPAP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QS96"/>
    <dbReference type="STRING" id="1365484.W6QS96"/>
    <dbReference type="OMA" id="DQESPYY"/>
    <dbReference type="OrthoDB" id="348201at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039913">
        <property type="entry name" value="RPAP1/Rba50"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013929">
        <property type="entry name" value="RPAP1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013930">
        <property type="entry name" value="RPAP1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21483">
        <property type="entry name" value="RNA POLYMERASE II-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21483:SF18">
        <property type="entry name" value="RNA POLYMERASE II-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08620">
        <property type="entry name" value="RPAP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08621">
        <property type="entry name" value="RPAP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RPAP1 N-terminal" evidence="4">
        <location>
            <begin position="91"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="RPAP1 C-terminal" evidence="3">
        <location>
            <begin position="289"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="136"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="391"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="59"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="87"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="164"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="397"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDM32357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="454" mass="49164" checksum="400DB212D80E5946" modified="2014-04-16" version="1">MAFRGERFLLDLDGESGAPEIPSPFSLIGEIQERAPPTAIPPAPKLPTLSSSTGFPAPRPRKPSSFKQRRANQSTPPTPVPTQPTVQDDKKSIDEENRRQLAAMSDAQIQQEREELMEQMDPGLLARFLRRANIEEDEKTGFEPPAPVADEKPKPKKSVSFDTPSSAPVSAPSAQHSLPKPSPKPHPRNEDLAPPNLPQDLRPASERPSLDPATLETFHFPQPKAPMPVLDPSSPSFLTDLQSHYFPEIAQDPSTLSWMQPLSADEEDPDSTSAYHPASNAISMAPSAIRFSLRGTILAPETSLSLPTTMGLHHHGEDPHAAGYTIPELAILARSTFPAQRCIAWQVIGRILFRLGRAEFGERGGQLSDGLWFVIEKEGIVAGMLAEADGAAGQTQGRDKSKNAKDAEGSNLPLASGVGRHASAAAWAVEGIWLWQKGGGGDRGLLKENQHRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W6QSR0</accession>
    <name>W6QSR0_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Major facilitator superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S02g002678</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QSR0"/>
    <dbReference type="STRING" id="1365484.W6QSR0"/>
    <dbReference type="OMA" id="IPLFVNH"/>
    <dbReference type="OrthoDB" id="18110at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23524:SF1">
        <property type="entry name" value="MRH DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23524">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04850)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="219"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="297"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="352"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="386"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="417"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="502"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="530"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM32527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="560" mass="59678" checksum="8C51E42E79E6E0CB" modified="2014-04-16" version="1">MASSPALFTASRSQTLTYLLAVCPFSIAFLVYINSSISFVVTDLIGLQNGVGDAVGTLGFADELLALVACPLWGVLSDRIGVRHVCTAGYAIVALALVVFVQATNVYPQLLLGRLLFSIGGSAVSTMVTAVLPTVTGSAFNAQKYRASMSSELTITPERARNGHSVDVDAFRASPSARLSGFVGMCAGCGALVALVVFLPLAARFEKMGLSPSQAIQRSYYLVAAISLIICLVCFIGLRDLPGEQGKSWSALWKTSHESDDDEDDDDDIYIHRPRLSYWKQLTTALTLGFRNRSIGLGYVGGFVARASSVGISLFIPLAVNHYYRASGLCDEEREPVPGSGLGDIKKACPRAYIVASILTGVSQLVALIAAPAFGYLTDKSRRYNFPLLFAALVGIIGYIIFAMLPNPLFERPDGNPGVFVVMALLGISQIGAIVCSLAVLSNGILRVSIDNETLRKIYEERRVRGDENDTEPDEGQALLPGSANRRLEHLSHLKGSIAGVYSLYGGAGILLLTKVGGLLFDILSAGTPFYIMAGFNGVLLVIGIVCGAINHFGSWPGRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W6QTS1</accession>
    <name>W6QTS1_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GTP binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S06g000511</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792020">
        <property type="protein sequence ID" value="CDM37549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QTS1"/>
    <dbReference type="STRING" id="1365484.W6QTS1"/>
    <dbReference type="OMA" id="SNCTGHN"/>
    <dbReference type="OrthoDB" id="8954335at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00882">
        <property type="entry name" value="Ras_like_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G" evidence="2">
        <location>
            <begin position="30"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="254"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM37549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="430" mass="48068" checksum="C5D41D391AB06288" modified="2014-04-16" version="1">MDMRSVVSQTERFAAFTGVTKPSPNDRFFLVMGMTGSGKSTFIGRCTGEDVTVGHGLYSCTTSIDVFNFDCNGHKVYLIDTPGFNDTNRSDIDTLSVLATYLGASYANGVRIHGILMLHPISDNRMSGSSMRNLDMMKAMCGFASYSTLAIATTMWSEKSPLCEQREAQLLSEERFFGRFISRGATTFRHNEKGRLGSLEEITSARRIVTHLILQSEKHLPEVLELQREIIDQGKVIGETKAGIVIAGDLYKARQAHKLELKKLKQAIETEIAQKNTAHAIEMQELKVDLENQMRKAEHNKRKLEKSMRDLHKDEERAWKKKLKVLEERFFEELAAKEQELRDMEESLAEIRKDTARRAKNSRKVALELEGYEQEVDAVRGEVSEARNTYQKLSEKKGNLFNGAANGIASGLASGIISGALAGGLLCTVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W6QU16</accession>
    <name>W6QU16_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S02g003178</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM33027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QU16"/>
    <dbReference type="OMA" id="DQFADWE"/>
    <dbReference type="OrthoDB" id="4356630at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="193"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM33027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="217" mass="24425" checksum="567277BE504E707F" modified="2014-04-16" version="1">MGYIVSTLCRPRALPEFPVVIAWVSPEDIVSLVDATETLEIKGLEACSVTIEQMTNVTTTPSVDESGGKETERTAEQYSHGYFYCIQTKRLDRRVNYTCCIHLIVLAPGLQVPRRMIGIVGPSAISPYVQVILVPETPLFPAELLQKVAISDNSQLSAIESLRYILTGADEFADWESDWGDLIIWWLLLLKPYWFLIAFSLVFFPLLVLVIVLVFVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W6QU37</accession>
    <name>W6QU37_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Probable beta-glucosidase btgE</fullName>
            <ecNumber evidence="4">3.2.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Beta-D-glucoside glucohydrolase btgE</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Cellobiase btgE</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Gentiobiase btgE</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PROQFM164_S02g003198</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Beta-glucosidases are one of a number of cellulolytic enzymes involved in the degradation of cellulosic biomass. Catalyzes the last step releasing glucose from the inhibitory cellobiose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 17 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="4"/>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM33047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QU37"/>
    <dbReference type="STRING" id="1365484.W6QU37"/>
    <dbReference type="OMA" id="VVCPYAT"/>
    <dbReference type="OrthoDB" id="4082933at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042973">
        <property type="term" value="F:glucan endo-1,3-beta-D-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050732">
        <property type="entry name" value="Beta-glucan_modifiers"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631:SF24">
        <property type="entry name" value="FAMILY 17 GLUCOSIDASE SCW11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0134">Cell wall</keyword>
    <keyword evidence="9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="8 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00039284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00041495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00041516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00042762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CDM33047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="614" mass="62442" checksum="F066F3870FF41FF1" modified="2014-04-16" version="1">MKGAIFAAALVGSAMADGVHRRHDAFHQRREAAVSAWSSAPAEAEQTCGCTTKVITVYGSATLVDESVVPATSSVPAETVAIPSSSSTPIAIPETSTHTSTVQSTSTSTLTVTVSGVGAESASSSVPAVSTFATSSVASTPAVVLPTPGVSTFSTTGVYTIPATTITVWDTTTVCGATSTEVPSGTVTYGGVTTIVETATTVTCPYATVKPSGSTVTSVIETTTYICPSAGTYTIVPPTTTSVPTSTVLVYPTPQTIVPGTYTQDETTVTVTRTDYTYICPAATNTLASTTAAVVPTTAAAATTAVPVVSTSTVAPVVPVSMSTASVVSSSSSTSSSASSSSTAKATGVPTVLGEGQYGMTYSPYTAAGDCKTKAAVLSDLTTIKSKGFNLVRVYSTDCSGLEYIGEACKSLGINIIMGVYIDGSGVSAAKEQVTEIIAWAEWSMVELIVVGNEAIQSGYVDAATLASFIESSAASFKAAGYTGLVTTTEPINVWQQYGSATLCSAVDIVGANIHPFFNADVTAAQAGEFTKSEFEELEEICGGKDVINLETGWPNAGDSNGAAVPGVSEQATAIKSIAASVGSKSIFFSFSDDTWKSAGEFNVEQHWGCSSVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2024-10-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>W6QUD2</accession>
    <name>W6QUD2_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S02g003289</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM33137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QUD2"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM33137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="35" mass="3982" checksum="DB804A1E45A0F094" modified="2014-04-16" version="1">MLGVLSSNEMSWAVNNLIVIWTLSFRRGCVDFGHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W6QVY2</accession>
    <name>W6QVY2_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S10g000063</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792024">
        <property type="protein sequence ID" value="CDM38249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QVY2"/>
    <dbReference type="STRING" id="1365484.W6QVY2"/>
    <dbReference type="OMA" id="EVLTMNH"/>
    <dbReference type="OrthoDB" id="3938867at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="377"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="381"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM38249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="573" mass="65520" checksum="662BD847B0782E8D" modified="2014-04-16" version="1">MGTRGLEIVRFRGRYYIRWHRFDSYFEGLGAKIVASIPTDPEKYNRWLESMRAQYAAKESVLDRDVYEIRDGVKPDYSQFEEFESLPSDFPELNNWAEYIYIINLDHEVLTMNHTIHWKLGNVPRQDDLWLRAIVGSIYRYESTISPEICPEEHMASPALEYPEPTWDIKYDFRIVSPRTDIAEAPKAFVTQVLADTISQYETQIITFGKEWSPSSFPFRELTFALVSIASGQTKFHSFPVQECNPRTCQRWTCKSSHLHRLPGWVDEEWVGDSAPLLEFGSPAHRPGEPPGASPMETIYWVEDVLVSLALVVDGDSISKAVAWGVERGHTNFQIVILSLFEVAFAEVSFDGEAGPFAKASKAVKLSPLRVDACASTHPRQRPELKPGMEAQNRDGKRTVNSDCKGTIRRLQRHFPGLAALVNFFEVASSRRAASKLAGILPLELYDRIVDFVDYDTWKTCLQVSTGVRSCCLRKYRLDDHMRIVSGPFVRQVHHYRYTQCLMSFDFEDMKTGQILPMMHAPGSDSIRECNWVPVIGSDRKAIMLDIMIQFKPVEDVPVEDDSDDDFLHTPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W6QWE8</accession>
    <name>W6QWE8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S03</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S03g000556</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QWE8"/>
    <dbReference type="STRING" id="1365484.W6QWE8"/>
    <dbReference type="OMA" id="FELPWSY"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF31">
        <property type="entry name" value="LAEA-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G01930)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM33832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="250" mass="28842" checksum="93906AA67EFD971F" modified="2014-04-16" version="1">MLLKGELFQAPIKNPKRVLDLGTGTGLWAIEYAEQYKSRLRGDCAIQPSWVPPNCRFEIDDFEQPWSYSKPFDYIHGRELEGSIRDHDLLFKRVLSNLNPNGWFEIASFDVNTYSDDGTHLGATNLLLSIKHMHESARMFGKDMTSSPSWKTRMEKAGFVNVKEDIYKLPQSPWPKDPKLKDLGRYHQLNMLEAMPIYTYALFSRVLGWTRSEIEGLLAGIRMELRDTSHHLYTKLRVVYGQKPGEPMSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W6QWZ1</accession>
    <name>W6QWZ1_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AMMECR1 domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S03g000771</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QWZ1"/>
    <dbReference type="STRING" id="1365484.W6QWZ1"/>
    <dbReference type="OMA" id="MATVEHC"/>
    <dbReference type="OrthoDB" id="24630at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.700.20">
        <property type="entry name" value="Hypothetical protein ph0010, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023473">
        <property type="entry name" value="AMMECR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036071">
        <property type="entry name" value="AMMECR1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002733">
        <property type="entry name" value="AMMECR1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027485">
        <property type="entry name" value="AMMECR1_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00296">
        <property type="entry name" value="TIGR00296 family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13016:SF0">
        <property type="entry name" value="AMME SYNDROME CANDIDATE GENE 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13016">
        <property type="entry name" value="AMMECR1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01871">
        <property type="entry name" value="AMMECR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143447">
        <property type="entry name" value="AMMECR1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51112">
        <property type="entry name" value="AMMECR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMMECR1" evidence="2">
        <location>
            <begin position="96"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="110"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM34047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="335" mass="37115" checksum="A651D1DC63CD5BAA" modified="2014-04-16" version="1">MANTAQCYYCFESLLASFEDREPTTLAAVEALWEQHEQTKKFSSLEEQIEEEDTGRQQSVNELDEDDDSHQSSQSSSQPTKMKLRSISRLQSQFSTSSSIATSSSAASNTSSISLQSSSTNITTPSVVSETPQLRSPDQRYPLFVTWNTLSRSGHKSLRGCIGTFEAQELAAGLKSYALTSAFDDTRFEPIPKSLLPSLSCSLTLLGSFEPCTDAMDWSLGTHGLRISFIHRGRRYGATYLPDVAVEQGWTKEETVESLMRKAGWDGGSSSTARRLLRGATDGNSSATQPWDQVSDFRTVRYQGLKASASYSEWQEWREWVLALDDGEEILEGAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W6QXA6</accession>
    <name>W6QXA6_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S03</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S03g000916</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QXA6"/>
    <dbReference type="OMA" id="YSAGIHN"/>
    <dbReference type="OrthoDB" id="4774651at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="497"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="520"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="536"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM34192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="591" mass="68033" checksum="11545811BA620F4D" modified="2014-04-16" version="1">MVYGKFNHQNVVGEELPFVRCSNGSASNHTNHYFTTLYTKRNRLDIGLLISLLQKEQREVTTEVYTAIYQTSSRAQFCDVVHLGGRGAIQRQFPQCTVKFRTFVPKDIEKHPYAIFYSAGIHNHPPPPPSKPPYDLIEELWNLLSRGQTSDLTLSAFLRSDGVRDLAARYGAQTLSELYQSFANKERFSVVLTKRRAIDYPMGRHLVGVYFEMEKNPAIKLYVREIVYNEKGAFIFCALNEQLEILASLHSFEVDMSYKRVKGVFNEVIFATFVPKHGKIMTLFRVFTDQETTKAYHFIFGNVFNLVERCIGKKIKFHYLHGSGIRSIITDMCPKQMTGLGKMLQETDQKTNNRDLGWRWHTMNVLIFSHNPELKGWAEHKKIDVIAAGLCNACSPIDSMFFEEARKHTNAVEQSHYKSYHMGTQDTLLGTVTKSKILDETDVQQYHSREAFDIRHSYHTDDMQTRFSKSIQREESLRRKRYQVLDDDVAPEDKELYEFNSSGNHSIPRAGSKKAKRGRGASSSQGRSTSRAITPAVSNLRHTTSVNTGNNSQDENSIESLEDQRKKVKKLREDLKQQERQLVLRERENTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W6QY96</accession>
    <name>W6QY96_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RBR-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PROQFM164_S03g001246</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.31"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.3.2.31" evidence="2"/>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QY96"/>
    <dbReference type="STRING" id="1365484.W6QY96"/>
    <dbReference type="OMA" id="CCHKPIE"/>
    <dbReference type="OrthoDB" id="9977870at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22584">
        <property type="entry name" value="Rcat_RBR_unk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031127">
        <property type="entry name" value="E3_UB_ligase_RBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11685">
        <property type="entry name" value="RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01485">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="9">
        <location>
            <begin position="128"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDM34522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="316" mass="36749" checksum="BE3DF9BE234A34CA" modified="2014-04-16" version="1">MDQGTRKETERLILELLLEDVNSNIHRLGEQPLPKDTTHPTYRLEELEPDRRVALHIWKSEIERQRVTLRYSQMAKALSPGREVKETQFPKGTKTFSKHTSTAIQKLVRFFKNLMRSIKALIPAHFSLPQVCSSCREVHSEIFKTQCSHFYCKNCLIRMVTKSLVDESLFPLQCCHKKIEGSEMKKMIGSALAQEQRKRQTELSDPDRTYCSDCTCSRYISPANKSWPDLIFKPALTCQCGVRTCRVCKKSAHEGKCLPQLDWLMEKLMNKKSWKRCTKCSRVIELKEGCPHIICICRAQWCYHCGKKWKTCDCPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W6QZI5</accession>
    <name>W6QZI5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="6">30 kDa heat shock protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">hsp30</name>
        <name evidence="6" type="ORF">PROQFM164_S03g001699</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QZI5"/>
    <dbReference type="STRING" id="1365484.W6QZI5"/>
    <dbReference type="OMA" id="HFWAKER"/>
    <dbReference type="OrthoDB" id="1431247at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06464">
        <property type="entry name" value="ACD_sHsps-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.50">
        <property type="entry name" value="Insect antifreeze protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016133">
        <property type="entry name" value="Insect_cyst_antifreeze_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031107">
        <property type="entry name" value="Small_HSP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11527">
        <property type="entry name" value="HEAT-SHOCK PROTEIN 20 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51156">
        <property type="entry name" value="Insect cysteine-rich antifreeze protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="SHSP" evidence="5">
        <location>
            <begin position="70"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="122"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="131"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="156"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDM34972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="234" mass="25458" checksum="685CE8403070DF0F" modified="2014-04-16" version="1">MAFFTTQSGLGPLFVLNEHELANQLKSPQCCKSNQCTKSSQCTKPNQCTKSSQCTKPNQCTKIQQCTKIQTPTSFMPAFDVRELTHAYRLDGELPGVDQSNIEIEFTDPHTLVIKGHTDREYISDDTNNGSASASSSRSSSAAGWHQATVEDEDAASTASSTDTAASSNAVSHAAKDDQPHFWAKERSIGDFQRTFSFTARVDQDAVRASLKNGVLSVIVPKEAAPTPKKIRIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W6R0I1</accession>
    <name>W6R0I1_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="10">cGMP-dependent protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PROQFM164_S04g000198</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6R0I1"/>
    <dbReference type="STRING" id="1365484.W6R0I1"/>
    <dbReference type="OMA" id="CEVDWWS"/>
    <dbReference type="OrthoDB" id="354826at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004703">
        <property type="term" value="F:G protein-coupled receptor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05578">
        <property type="entry name" value="STKc_Yank1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000354">
        <property type="entry name" value="AGC/YANK protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000469">
        <property type="entry name" value="Serine/threonine-protein kinase 32B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24355">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR KINASE/RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24355:SF30">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE 32B ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="20"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="9">
        <location>
            <begin position="277"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="385"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="385"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="403"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="423"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="457"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDM35317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="564" mass="63362" checksum="EB227E4660ABC2D3" modified="2014-04-16" version="1">MGNTQGKPMSCNDAVNLNHFRLLRVVGKGAFGKVRIVERKDTGLTFALKYIRKEEVVRSESVRNIIRERRMLEHLNHPFLCNLRYSFQDMEYIYIVVDLMNGGDLRFHISRKCFTEDAVRFWMAELGCALRYIHSQGIIHRDLKPDNVLLDSDGHVHLADFNVASDYRPGKPLTSKSGTLAYLAPEVYEGTGYAFEVDWWSLGVTFYECIYNKRPFEGRSQETLSENIKKAQPKYYVTNPAVSVACLRALGSLIQKDRTQRIGAIGFETYTSHMFFAEIDFEALERKQIPPVFRPSSEKTNFDATYDLEELLLEEAPLEARARRQKPRAELREDATAKEIRDEELHRLIETMFEPFDYTLTSYQGNAAEAIAAVINPEECFPIATTTQGNTTSPANPIAHARQFSQPDPKNTSPIQADGSHYRAQQSDNMTILSETPDPNDPATGQGPPSPSSRMSPSPPPPPPFQPPPAPSFHRPLPPNNRHRGATRQMSKSGGVQMVLNEAGSWSELAHNSTPADGMDNGDDKNKQANGMLSFFSRKKGRDRSPKPTEPGVLGKEGARQIIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2024-10-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>W6R0I4</accession>
    <name>W6R0I4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S04</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S04g000203</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6R0I4"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM35322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="50" mass="5628" checksum="6230B82216B51F4D" modified="2014-04-16" version="1">MLEVWNDLDSMPMPLTLVNSQSKALPTQIHPPTSRLNSHMLNHAISLLPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W6R0X7</accession>
    <name>W6R0X7_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S04</fullName>
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    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S04g000363</name>
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    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6R0X7"/>
    <dbReference type="OMA" id="ITECETY"/>
    <dbReference type="OrthoDB" id="4325974at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM35482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="494" mass="53713" checksum="0C60956D5BDBBD27" modified="2014-04-16" version="1">MNHLCGDRDGELFARSLVAFFAHFAASSDWSFEPSLPSSSDDPLGLEFLSRHPAFPRQIATEGLIPLLDNYIDRAISVFESTSDVRLTPPQCNLPPASSIYDIPQAPVFTMSQSIEDNMQTGPPGPKDLCQIASSCMLSAFNLRNAVKGAKDNLIRTATDRPTIPKSSIVSSAEYVFATVMFGGLWYFYASHSSVKPILDTWCSWLNDRVSGARAPPITTIPWLGSTKSLFTADTETDILATLWTFVTRGAGNLQPTGYQASFSEFYSMMALRAGVSFVACDGTLVVDVAVVVQTVAQIPNLGYDGMTGDQRGAAIFLNGDMGKAWATHFLAALRWYTICSPSAMGLSAIASGLYAYTSKRHGPGYWKYVRPRLICAQGHTSGFDLPVCIPSFWYDGGLEGCRPEPLHPCSHRPRPIYISPLIDAINAVSSITECETYDQWRSQIDTSVASVDSWLRDLATHGESDVLLRATAGAAPSFINLVSSTLAAVLDYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W6R391</accession>
    <name>W6R391_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transposable element</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S05g000090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6R391"/>
    <dbReference type="STRING" id="1365484.W6R391"/>
    <dbReference type="OrthoDB" id="4357582at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004880672" description="Transposable element" evidence="1">
        <location>
            <begin position="25"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM36257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="133" mass="15360" checksum="36066E4AB58DD376" modified="2014-04-16" version="1">MPIDALLTFRSILITLGFCPFCLGDKRSADSLAAVFCPHLCYEGRKYIDNLYLQWHFFDIYSIEEPRSNCVKRKRKWQLQSEPAGTTFGNLSDETLPSLEDYFLTSTLPTSFEDSDMTSADDLFMEFVRLDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W6R5I0</accession>
    <name>W6R5I0_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Peroxin 11B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PROQFM164_S06g000032</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Peroxisome membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792020">
        <property type="protein sequence ID" value="CDM37072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6R5I0"/>
    <dbReference type="STRING" id="1365484.W6R5I0"/>
    <dbReference type="OMA" id="MFFTTFT"/>
    <dbReference type="OrthoDB" id="3636394at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008733">
        <property type="entry name" value="PEX11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12652:SF23">
        <property type="entry name" value="MICROBODY (PEROXISOME) PROLIFERATION PROTEIN PEROXIN 11B (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12652">
        <property type="entry name" value="PEROXISOMAL BIOGENESIS FACTOR 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05648">
        <property type="entry name" value="PEX11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="1" id="KW-0962">Peroxisome biogenesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00046271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM37072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="223" mass="24580" checksum="2DE60400777F09AF" modified="2014-04-16" version="1">MIQHFSRFVKSGAGLEKTLRLIQCVSQVVAALTVSNVLAVQLTTVKLQLALTRRYFRFFGFIDSFQRMLALLGKDGFGSVAGLLELAKCTCFGLYFVLEDLTTLHAMGVYAVTWNDPVMNQANTFWLYALSFSVAEAIWALLVSPAEQPSKKNGKRKNRKIASEKTPVKSTVTSARVKQIVVDGCDLLIPLELLGWMPTGDVVVGSTMVLSTLLTAQEVWARV</sequence>
</entry>
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    <accession>W6R7Z8</accession>
    <name>W6R7Z8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S08g000033</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
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            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
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            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
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            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792022">
        <property type="protein sequence ID" value="CDM37982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6R7Z8"/>
    <dbReference type="STRING" id="1365484.W6R7Z8"/>
    <dbReference type="OrthoDB" id="1930084at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM37982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="67" mass="7721" checksum="30C813CD0639E237" modified="2014-04-16" version="1">MPESKIPQPGPAKLKRNAGPDEWLEAAKDCKYLSEPHMKQLCEIVKEYMMEGKIKYPTSIDTCHSLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W6PR84</accession>
    <name>W6PR84_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Endoplasmic reticulum-Golgi intermediate compartment protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PROQFM164_S01g000189</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Plays a role in transport between endoplasmic reticulum and Golgi.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Endoplasmic reticulum membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Endoplasmic reticulum-Golgi intermediate compartment membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Golgi apparatus membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ERGIC family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PR84"/>
    <dbReference type="STRING" id="1365484.W6PR84"/>
    <dbReference type="OMA" id="QRHEGCR"/>
    <dbReference type="OrthoDB" id="270930at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033116">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045888">
        <property type="entry name" value="Erv"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012936">
        <property type="entry name" value="Erv_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039542">
        <property type="entry name" value="Erv_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10984">
        <property type="entry name" value="ENDOPLASMIC RETICULUM-GOLGI INTERMEDIATE COMPARTMENT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10984:SF25">
        <property type="entry name" value="ENDOPLASMIC RETICULUM-GOLGI INTERMEDIATE COMPARTMENT PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07970">
        <property type="entry name" value="COPIIcoated_ERV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13850">
        <property type="entry name" value="ERGIC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="25"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="403"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="Endoplasmic reticulum vesicle transporter N-terminal" evidence="8">
        <location>
            <begin position="8"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="Endoplasmic reticulum vesicle transporter C-terminal" evidence="7">
        <location>
            <begin position="143"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU369013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM26380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="438" mass="48009" checksum="9A3AFDAC11A0D00E" modified="2014-04-16" version="1">MSAKSRFTRLDAFAKTVEDARIRTNSGGVITIASLLIVMWLVWGEWADYRRVVVLPELVVDKSRGERMEIHLNMTFPRLPCELLTLDVMDVSGEQQVGVAHGVSKVRLSPRDEGGKVIDVQALDLHSPSDAAKHLAPDYCGECGGATPPPTVIKPGCCTTCEEVREAYAEKQWAFGDGSNIEQCKREGYAEKLAEQRREGCRIEGVLKVNKVVGNFHIAPGRSFTTGNMHVHDLDAYIAPNAGPADQHTMSHFVHELRFGPKLPAELAGRWGWTDHHNTNPLDDTKQETDEPAYNFMYFVKVVSTSYLPLGWDPQFSTAIHNAYDSAPLGSHGLAYGTQGSIEAHQYSVTSHKRPLSGGNDAAEGHKERVHAGGGIPGVFFNYDISPMKVVNREARPKTFTNFLTGVCAIIGGTLTVAAALDRGLYEGAMRVKKLHSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>W6PS09</accession>
    <name>W6PS09_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Heat shock protein DnaJ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PROQFM164_S01g000812</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PS09"/>
    <dbReference type="STRING" id="1365484.W6PS09"/>
    <dbReference type="OMA" id="KWHEDGD"/>
    <dbReference type="OrthoDB" id="550424at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10719">
        <property type="entry name" value="DnaJ_zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.230.10:FF:000002">
        <property type="entry name" value="Molecular chaperone DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.230.10">
        <property type="entry name" value="Heat shock protein DnaJ, cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044713">
        <property type="entry name" value="DNJA1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001305">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43888">
        <property type="entry name" value="DNAJ-LIKE-2, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00684">
        <property type="entry name" value="DnaJ_CXXCXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="DnaJ/Hsp40 cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51188">
        <property type="entry name" value="ZF_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0346">Stress response</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004881533" evidence="7">
        <location>
            <begin position="23"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="8">
        <location>
            <begin position="24"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="CR-type" evidence="9">
        <location>
            <begin position="149"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CR-type" evidence="6">
        <location>
            <begin position="149"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDM27003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="422" mass="47269" checksum="C45D14C60BAFF3C9" modified="2014-04-16" version="1">MQLLRLLVTLAVVLFSVVVIAAEDYYKVLGLAKSASERDIKRAYRTLSKKYHPDKNPGDDTAREKFVEIADAYDVLSTTTLRKVYDQYGHEGVEQHRKGGAAGGGGHDPFDLFSRFFGGGGHSGHAPGHRRGPDMEVRAALPLRDFYNGREINFLVEKQQICDSCEGTGSKDRQVVTCDRCAGRGIVIQKHMLAPGMFQQVQMQCDKCHGQGKKIKNPCPVCEGNRVVRNQVETSATIEPGMGKGTRLVFENEADESPDWIAGDLIVVLDEKEPELGESEEERTDGTFFRRKGKDLFWKESLSLREAWMGDWSRNLTHFDGHIVRLGRGRGEVVQPLAVETIAGEGMPHYSEGHLHDHHEENDEAGNLFIEYTVVLPDQMESGMEKDFHALWEKWRKKIGVDLAEDSGRPVVPPPAEDKDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W6PSH9</accession>
    <name>W6PSH9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g000987</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PSH9"/>
    <dbReference type="OrthoDB" id="10588630at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004881041" evidence="1">
        <location>
            <begin position="28"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM27178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="125" mass="14125" checksum="BB07425B6789EB67" modified="2014-04-16" version="1">MSQSNRSKSVGFYLAFLSLSLHAFTHALETTTISISPEELHDASNSPQSIQNDVDKSLFHLNWLDDYLSRSVKTAVSRKNRPSTCDRWQPGWIQPLAQYRLPVVPVGLGSRRSRSHPHIPMPSIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W6PSK9</accession>
    <name>W6PSK9_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Topoisomerase 1-associated factor 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">tof1</name>
        <name evidence="13" type="ORF">PROQFM164_S01g000644</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the timeless family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PSK9"/>
    <dbReference type="STRING" id="1365484.W6PSK9"/>
    <dbReference type="OMA" id="VNHHRHT"/>
    <dbReference type="OrthoDB" id="310853at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031298">
        <property type="term" value="C:replication fork protection complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000076">
        <property type="term" value="P:DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043111">
        <property type="term" value="P:replication fork arrest"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048511">
        <property type="term" value="P:rhythmic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044998">
        <property type="entry name" value="Timeless"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007725">
        <property type="entry name" value="TIMELESS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006906">
        <property type="entry name" value="Timeless_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22940:SF4">
        <property type="entry name" value="PROTEIN TIMELESS HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22940">
        <property type="entry name" value="TIMEOUT/TIMELESS-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04821">
        <property type="entry name" value="TIMELESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05029">
        <property type="entry name" value="TIMELESS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0236">DNA replication inhibitor</keyword>
    <keyword evidence="13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-0469">Meiosis</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Timeless N-terminal" evidence="11">
        <location>
            <begin position="40"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="Timeless C-terminal" evidence="12">
        <location>
            <begin position="932"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="318"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="569"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="795"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="886"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1024"/>
            <end position="1150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="324"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="569"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="586"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="1038"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1070"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1091"/>
            <end position="1104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="1117"/>
            <end position="1127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF05029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDM26835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="1172" mass="133567" checksum="D58B0F2040EA6C39" modified="2014-04-16" version="1">MDEEVVPLGHDVQVVDPDVRNYVYGLVTALGGFNGEDADQYVLGDDALACLRDIKRWLKLYDEKNNRMDVARCLGEANLINGDLLPILSLWWTSGQNSKHMTRIALACLELLVPLTWPVEIHSQMTVNHHRHTPYIQQTQVQYKRGILRSGGLNILRAVIRISLPSMATPRSERGTRDEGILKLMLYLLRNIAIISPNTRLAAEGDEEETSRSATINAFHEQDAFALLLTMCSNVGEDFNLQDIPLMETIFHIVKGVNVEKLFMDDEQRKAKGTDELGDLLRKELLVRREYAKNAPTRHGRFGTMIWVKRDDEKMSTVSGQSVLRDDQTTLQKMDESKKWNKPRPRRRQEDVDQNSNFNMPAHLSSEATKNLRTFVEEFLDSGFNPLFTHVRKAIEREAERVVPINHRQFFYLVGWFLEAERIRRARQLRHRTAQNGGRTKDIEPDSYGLVAGVLNQETFISLNRAMQNSLDNKEWEDINAQMRCFTQILLTVQEMAVSPLEEDQEIAENIQNRIFYEETTHDRILTIVRGYKDQGFGYLDACTELAHVFLRMLERYSKDNADMQIRSRRKAKQKQKKAAQVAEKEGEDDDEERDSEDEDMEEAAQVTKERSFDFKRFSAKFCNQNCVDTFISFTGFYRELNPEQLKRAHRYFYRIAFKQEMTVLLFRVDIIGLFYRMIKGPGPMDSNEPIFKEWEELVRQIIRRLVKKLEQRPALVTELLFSKINSTIYYLEYGHEKQTISTYKRPPPELMITSTEATTREAKLHIVVSALVLDGRADLATWIKDVLSSAASEREDWETQEEVNRAENSETTGVPNPMIPVKGKNEFVQNAMFSNAKLRLLMTVVGFERLGVEDVLGASWVVPASLKSDDLRETVSEILKALQNPFSGDVNDDPRKQIQPKHRGSGRGSTTQGTLDVNFGSESEGEDIPDGPLFPANLRSKSSALDDLKKKRKKKQKATTETEPLDEETLEARRDARLSNALSRQAKIKSDLFIHASDEESDAEADKEFFRLEEERRIQQAKEIKKALLTGPVQPPRKGRGKKSAARKRTSDTGTSAAAKSKRQRRDSGSAASEAGSDADGDILMAELDVQSSHSQQGISTSHGAGEDEDTRPTPSDDDLAFDDDFAFTRDHPSKPQATEPDSVDDDVEDEPVVLARRRMRGGFVIESDSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W6PSQ1</accession>
    <name>W6PSQ1_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g000555</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PSQ1"/>
    <dbReference type="OMA" id="RRNWFIS"/>
    <dbReference type="OrthoDB" id="275936at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038781">
        <property type="entry name" value="C365.16-ike"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37845">
        <property type="entry name" value="SEQUENCE ORPHAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37845:SF1">
        <property type="entry name" value="SEQUENCE ORPHAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM26746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="336" mass="36664" checksum="83093B1B1C77B95E" modified="2014-04-16" version="1">MSTNRDAVVQDTIFTMATVKEQGQECQGQAPSKRSTASTWNTKDLGKRIGVDVASAATAGALTCPLITIIDRAIMEKASKGFPIRQTINNGLRSMVARPCGFFFSTPFILIYTLYTSTYLTANAIDTLRSTTHHQPYNVIDTGLPKFFATTIVNMTICVYKDARFAKMFGASPPSESNVTVNTNPVAQKYSSALRAPCAPSAPIAPNLQIPKVSYALFCLRDSITIWASFNIPALIAPSVPDFLASSPTMKSSIAQFACPAAMQFASTPMHLLGLDLYNRQPAGGLHWTDRLARIRRDYVPSCFARMGKIVPAYGVGGVVNVRMRDSLMRRIERGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W6PUV4</accession>
    <name>W6PUV4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g001481</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PUV4"/>
    <dbReference type="OMA" id="RIFEHHH"/>
    <dbReference type="OrthoDB" id="4526540at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM27670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="83" mass="9908" checksum="839D681384B821A5" modified="2014-04-16" version="1">MPEDSQHPVKDKEPLIERIFEHHHHKHNQEEDAHSDKQNGPSNKKDKPKFYDDYLKKDEKALKDYYEKDKELEAEGQTYGGLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W6PV94</accession>
    <name>W6PV94_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein YOP1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S01g001601</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PV94"/>
    <dbReference type="STRING" id="1365484.W6PV94"/>
    <dbReference type="OMA" id="WMPWGWG"/>
    <dbReference type="OrthoDB" id="434647at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004345">
        <property type="entry name" value="TB2_DP1_HVA22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12300">
        <property type="entry name" value="HVA22-LIKE PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12300:SF177">
        <property type="entry name" value="PROTEIN YOP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03134">
        <property type="entry name" value="TB2_DP1_HVA22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="275"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="294"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="309"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU362006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM27790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="324" mass="36052" checksum="3BB2B9CB0B909007" modified="2014-04-16" version="1">MFGIFADLLSSVITILFPVFASYKALRSSDPSQLAPWLMYWVVLSVILLAESWTFFIIGWFPFYSWIRLGFMSYLVLPQTQGARLLYQDYVDPFLTHHERGIEEMIGRTHERAKALGLQYFYKAIDFVRQRVLGLPPQRPTPPQPGAASYAQSLLSRFNIPVAGGAGAPANTTDWYSLFSAAVGSVTTGKSREVRDEELSASGTLLQRQLQSMSGTEKAQFISSQREVLDYLRSTLTQEEQSTPRGGLEADDLAYGVPLRKNRSENSFEVVDADLGSRPEQKTSGWTSGWFGNEQDSSGSSGTDFAARAVDEIARSRTTGHDRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W6PW18</accession>
    <name>W6PW18_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g002234</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PW18"/>
    <dbReference type="STRING" id="1365484.W6PW18"/>
    <dbReference type="OMA" id="EMTNTEC"/>
    <dbReference type="OrthoDB" id="2520703at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056867">
        <property type="entry name" value="LRR_15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24969">
        <property type="entry name" value="LRR_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Leucine-rich repeat" evidence="1">
        <location>
            <begin position="171"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM28423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="439" mass="49642" checksum="46AE65D3A5C094C5" modified="2014-04-16" version="1">MVMLLDLPEEALCLIAEELPFQGDRCSLIRSCRRLYTVLLPALYSRVILGNCTHHTIGQASRLVNAIARRPQLANAVRSIRLGYWDTEDANEEVDVDYEYDRELLDGFVAGTCWSKQPHEQLRLGNTDAWLALLLPQLKGLRRISICYPDMSEYVTGMFVKAAREDTTAFSRLVEAFGEWYDTENSIHASLMDPFFKFPAMRRVGGHAIVDNAREEEETRIIPFSDVTDIDLDMTNTECGFRVWIESCKALKTFRLNIGGGMISDGPEIVSAPLQESISLHKTTLEGFWLCGESYEPPEDDEGWMGSFADFNMLKYLHISISMLAKLDEDFEPTQELMAILPPSLETLYLCHCHNELLGWAVDQIDRLIESNCLPRLTSLGLEGYGPSEVQQSSLETMRKLEELHKKCADAGVFFATSIGSHRVVPSHFVSLWPCAYDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>W6PWQ1</accession>
    <name>W6PWQ1_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">D-xylose reductase [NAD(P)H]</fullName>
            <ecNumber evidence="2">1.1.1.307</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PROQFM164_S01g002166</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the initial reaction in the xylose utilization pathway by reducing D-xylose into xylitol. Xylose is a major component of hemicelluloses such as xylan. Most fungi utilize D-xylose via three enzymatic reactions, xylose reductase (XR), xylitol dehydrogenase (XDH), and xylulokinase, to form xylulose 5-phosphate, which enters pentose phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>xylitol + NAD(+) = D-xylose + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27441"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17151"/>
            <dbReference type="ChEBI" id="CHEBI:53455"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.307"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>xylitol + NADP(+) = D-xylose + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27445"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17151"/>
            <dbReference type="ChEBI" id="CHEBI:53455"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.307"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.307" evidence="2"/>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PWQ1"/>
    <dbReference type="STRING" id="1365484.W6PWQ1"/>
    <dbReference type="OMA" id="MYRNEKP"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19071">
        <property type="entry name" value="AKR_AKR1-5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000015">
        <property type="entry name" value="Oxidoreductase, aldo/keto reductase family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="2,5-DIKETO-D-GLUCONIC ACID REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827:SF13">
        <property type="entry name" value="ALDO_KETO REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00063">
        <property type="entry name" value="ALDOKETO_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="10">
        <location>
            <begin position="29"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="9">
        <location>
            <position position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDM28355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="281" mass="31149" checksum="FAAF49B5CC0FBA2A" modified="2014-04-16" version="1">MAKLTLQSTRQLQSGHGIPVLGYGVYMIPSSETAKVTLEALKAGFRHVDSAIMYHNEGPCGKAILNSKLDRSQVFFTTKIPPQSMGYESTKRAIDSSLKEAAQDYFDLILIHAPYGGKKARLGSWDALVEAQGAGKVRSIGVSNFGIHHLDELEAHIQSSGASQIDVGQYELHPWLDHSDIVEWLKKRNIVVEAYSPLAHGSRLKEPVLLSIGKKYGKTPAQVLIRWSLQMGFVPLAKSVTPSRIRENVDVFDFELEAEDMKLLDTGEYSPTDWDPTVDKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W6PWU3</accession>
    <name>W6PWU3_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">(2E,6E)-farnesyl diphosphate synthase</fullName>
            <ecNumber evidence="6">2.5.1.1</ecNumber>
            <ecNumber evidence="5">2.5.1.10</ecNumber>
            <ecNumber evidence="4">2.5.1.29</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Dimethylallyltranstransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Farnesyl diphosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Farnesyltranstransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Geranylgeranyl diphosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Geranyltranstransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">PROQFM164_S01g002052</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>isopentenyl diphosphate + (2E)-geranyl diphosphate = (2E,6E)-farnesyl diphosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19361"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58057"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="ChEBI" id="CHEBI:175763"/>
            <dbReference type="EC" id="2.5.1.10"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>isopentenyl diphosphate + (2E,6E)-farnesyl diphosphate = (2E,6E,10E)-geranylgeranyl diphosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:17653"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58756"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="ChEBI" id="CHEBI:175763"/>
            <dbReference type="EC" id="2.5.1.29"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>isopentenyl diphosphate + dimethylallyl diphosphate = (2E)-geranyl diphosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22408"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
            <dbReference type="ChEBI" id="CHEBI:58057"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="EC" id="2.5.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 19">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.1" evidence="6"/>
    <dbReference type="EC" id="2.5.1.10" evidence="5"/>
    <dbReference type="EC" id="2.5.1.29" evidence="4"/>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PWU3"/>
    <dbReference type="STRING" id="1365484.W6PWU3"/>
    <dbReference type="OMA" id="ANFAYFW"/>
    <dbReference type="OrthoDB" id="10029326at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004337">
        <property type="term" value="F:(2E,6E)-farnesyl diphosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004161">
        <property type="term" value="F:dimethylallyltranstransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004311">
        <property type="term" value="F:geranylgeranyl diphosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046165">
        <property type="term" value="P:alcohol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001">
        <property type="entry name" value="GERANYLGERANYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001:SF70">
        <property type="entry name" value="PYROPHOSPHATE SYNTHETASE ATMG, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G02400)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00444">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 19" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00032448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00033096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00049291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00049399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CDM28241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="362" mass="41301" checksum="4619CF670C78501F" modified="2014-04-16" version="1">MLGLTTAKIFAFISYFLSPITFFTNNKAASTYHHRRPDLRSFQIRHAQTNHTQQKFQSNDESDSGAREITEPYEKIVCAPLEYLLSIPGKDIRGKLISAFNEWLHLPDDKLAIVKEVIDRLHTASLLIDDIQDASHLRRGHPVAHDVFGIAQTINAANYAYFLQQKRLSEINDPRAFPIFTQALLDLHVGQGMDLYWRDALVCPTEAEYTRMVMYKTGGLFRLAVELMQIQSTTTTDLSRLVELLGIIFQIRDDYMNLQSGIYAKKKGLMEDLTEGKFSYPVIHSIRAVPGNMQLINILKQRSEDRAVKVRAVQYMESTGSFQYCREVLGGLMEQARSHVDELEILLGPNQGIRHILDLLEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W6PX04</accession>
    <name>W6PX04_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F-box domain, cyclin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g000308</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PX04"/>
    <dbReference type="STRING" id="1365484.W6PX04"/>
    <dbReference type="OMA" id="IDSYESW"/>
    <dbReference type="OrthoDB" id="1259151at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM26499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="596" mass="66358" checksum="7F51CD0AB9BAE102" modified="2014-04-16" version="1">MLSELPSEIIYQIATHLPTANALAHLSQTCHRLHGIITAENSRIFRAFVRSRFPYIETPPFWKDAARALTSRSRALDRKAIIGRFVVPPGTATKIGSHEVTRQDNPTLGYRPSIDSYETWNGQRWADRKEVLAWGAANQLVMRIKQTGVRAQEDWLVFNDIDHVSSYDDICSLHLLSSATRYSNDTHVEHLIFGRVRGDIVHLAISPNEATFEHKQKFISFGLNLDKTDLSSGTDSTLAAHFENGSIAFYHTETDDEVIEPFTWLRLEGSSRTNYSKLLSSSLVAVGTGNVENSLSISKITPDGVSVYRTIGIGSLDADSTSLKSKANIGAIEPLNEHNLGSPGEVFLTAWDDYTVRLHDLRSPRPSEVSYRDATDLNPIYSLHAFGHDRFLAGAGGEAVVKIFDLRMCNTYSYLDAQFPDSQFNANTIPRTKAKPRPKKGFSIFLSHPPPPTFPQQTPHPVRTRQRGPYRGPIYTMSSPSPSSPTVYTGIVDGVVQLDFASTDDLTGPGKEWYEYNLDLGVNMGPGSLPRWNAEAFNLAGYERPDDEDSATTSKLRTQRAFADLKPGDAARGTHTGWDCRWETLEEPGAWRRQDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W6PX30</accession>
    <name>W6PX30_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aminotransferase class-III</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S01g002326</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PX30"/>
    <dbReference type="STRING" id="1365484.W6PX30"/>
    <dbReference type="OMA" id="WGPLIFG"/>
    <dbReference type="OrthoDB" id="425114at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43713">
        <property type="entry name" value="GLUTAMATE-1-SEMIALDEHYDE 2,1-AMINOMUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43713:SF3">
        <property type="entry name" value="GLUTAMATE-1-SEMIALDEHYDE 2,1-AMINOMUTASE 1, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM28515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="432" mass="47533" checksum="EF41043042B86611" modified="2014-04-16" version="1">MDTALNDAVARFIERHPESQRLHKLSLESLPGGNTRTVLHTAPYPVFMRKGSGSELWDEDGNKYYDFVGELSAGLYGHSHPTLQKVLTDTIQNVGLSLGATNVYEQRYASLLCERFGLERIRFTNSGTEANIHCLAAARKFTGRRKVIVFRGAYHGSVLFFGDGIPENDIDQADWVLLQYNDPEGVREAFSQNNDIAAVLLEGIQGSSGYISASDEFLRTIREESEKAGAVMILDEVMTSRLAPGGLKDVLGIKPDLITLGKYLGGGLPFGAFGGRRDIMDVYNPLTPGALMHSGTFQNNTLMLHAGYAGLSEVYTAEVVQSLNTQGDDLRERLQRVFAGSKFCVTGRGSLMCVHATNTGVRAEQITCRDDFIGVEATDLKQLFWLELVNAGFWVQNRGSITLNIAMTTTALDAFVEAVEEFCKRYKSLVMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W6PX78</accession>
    <name>W6PX78_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g000378</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PX78"/>
    <dbReference type="STRING" id="1365484.W6PX78"/>
    <dbReference type="OMA" id="CFRKQHV"/>
    <dbReference type="OrthoDB" id="5431013at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="300"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="339"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="481"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="309"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="339"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="371"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="415"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="430"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="486"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="516"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="537"/>
            <end position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM26569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="608" mass="68008" checksum="2F16078F9015F00A" modified="2014-04-16" version="1">MAPGSQASIIKVAGAGFRLSLLLNAAACQLAQSRLEIHSIAKGISLFALVLKNVGQIIEGTDTERSPEATEKAWEISGQGQMIFIEIEHMLDKLKATDRDNDLMRIPLQDRLKWCFRKQHVTYLLAQLETLKLSLIVMLQTLELGDVLKSSIDDGIATDSFTATTNDAIAQEKAESQNMIIVRYWSVKRLDRLWDLVEQETLDAAKNPTNQRISFNYSSNTTSTSKPFAAATRHSDPTRLPIIALGNSDVELSDMEISPKDMVRLSESTLNRLLLLWVPSIDPSKLHHAAKGFNTSNNRVQPRVYVSSDAEEDDTEEPDFDNHSIRGYYLEGATVDWRDPHSQEARHHAAELRRKYSSYQAQVESEPEPDEYLKRRSSPRSDSRLIDSSDEAEQRPDTLRPSHSTNPMQGRRFHSNSVSSRYPSHNNPDSRPPAYPSGSFPPPNHALPRPPPLPSHTQPGPPQQPYKYYQNQDYAAIPRSIPTNVNQSNPAISIPNSNPSPRGTSPSQVYFEAPKTRNQAYNNIPNNNKLQPRHHPSTYPLSSSSPESSFRSSPTRSDQRSPSTHPRRSPREDAKDRKKALTRNATRGLVGIGAIAGFMDALEAFSIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W6PYE0</accession>
    <name>W6PYE0_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Drug/metabolite transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S01g002856</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PYE0"/>
    <dbReference type="STRING" id="1365484.W6PYE0"/>
    <dbReference type="OMA" id="VNAQWLI"/>
    <dbReference type="OrthoDB" id="5854584at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039632">
        <property type="entry name" value="TMEM42"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31965">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31965:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM29045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="146" mass="15124" checksum="7CDBFF907AC42C1F" modified="2014-04-16" version="1">MSTSTPQSIPQSSTSPWIVLAITSGAFAALNGVFAKLTTDDHTTAFAQSLAHLFGLESSPVIEMLTRGACLGLNVLCNIIMWALFTRALTAGPSTVKVSITNTASNFLATALLGMVVFQEAVGGLWWLGAGMMGAGCILVGMREGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W6PYR6</accession>
    <name>W6PYR6_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WD repeat protein 23</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PROQFM164_S01g002977</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PYR6"/>
    <dbReference type="STRING" id="1365484.W6PYR6"/>
    <dbReference type="OMA" id="IWDIRPY"/>
    <dbReference type="OrthoDB" id="1068471at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052234">
        <property type="entry name" value="U5_snRNP_Component"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44006">
        <property type="entry name" value="U5 SMALL NUCLEAR RIBONUCLEOPROTEIN 40 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44006:SF1">
        <property type="entry name" value="U5 SMALL NUCLEAR RIBONUCLEOPROTEIN 40 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="60"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="103"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="145"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="194"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="229"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="290"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="321"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDM29165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="357" mass="38851" checksum="3CD07091FCF8047B" modified="2014-04-16" version="1">MSGEKRPAPEGFGTSHQLVVKRNKAAENAGTELVKGSSQNGALIQSVPRTSGLDAPIMELTGHSGEVFAVRFDPTAQHIASGSMDRSILLWNTYGQCENYGQLTGHRGAVLDLQWSRDSRALFSASADMTLGSWDVETGERVRRHVGHEEIINCLDISKRGQELLVSGSDDGSIGIWDPRQKDALDYLQTELPITAVALSEAGNEIYSGGIDNTIHAWDIRKKAIVYSMAGHTDTITSLQISPDSQTLLSNSHDSTVRTWDIRPFAPTNRQVKTYDGAPVGLEKNLIRASWDPKGEKIAAGSGDRSVVVWETKTGKLLYKLPGHKGTVNDVRFSPNDEPIIVSCSSDRNLMLGELGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W6PYS3</accession>
    <name>W6PYS3_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Vacuolar protein sorting-associate Vta1, N-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PROQFM164_S01g000918</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the VTA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PYS3"/>
    <dbReference type="STRING" id="1365484.W6PYS3"/>
    <dbReference type="OMA" id="AYWCEYH"/>
    <dbReference type="OrthoDB" id="391137at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005771">
        <property type="term" value="C:multivesicular body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.420">
        <property type="entry name" value="Immunoglobulin FC, subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.270">
        <property type="entry name" value="Vacuolar protein sorting-associated protein vta1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044538">
        <property type="entry name" value="Vta1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039431">
        <property type="entry name" value="Vta1/CALS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023175">
        <property type="entry name" value="Vta1/CALS_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041212">
        <property type="entry name" value="Vta1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46009">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VTA1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46009:SF1">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VTA1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04652">
        <property type="entry name" value="Vta1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18097">
        <property type="entry name" value="Vta1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Vta1/callose synthase N-terminal" evidence="10">
        <location>
            <begin position="14"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="Vta1 C-terminal" evidence="11">
        <location>
            <begin position="353"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="186"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="205"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="267"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="317"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="327"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF18097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDM27109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="390" mass="41646" checksum="2540334042E48A84" modified="2014-04-16" version="1">MTSNIPAGLRSADIGRFAIRAAQIENAKPVIAYWCNFHIVNQIIERGLHNSDDAIKLYTTSLVDKLEQFKVENPDNDTVTDTVAASAYVEQFGLEVFSRAEAAMNANKVTKQTADTFQAAATFLELCSIWGPLDPELAGRIKFAKFHAVRIVKAFKAGEDPNVTNPAPKQEEELVNDPDVEAFDESVAEQASKPGQASIEEIPDESDRLGRELARKSTLDESLHPSRTSSTPRPPPEIPSVPRNAPGYPPQPADADPNTGGLELPSTPATIGGSSSVPKLPDTPTAFQSFPPPPEDPSVSTPDPASFYNTSGASAPIQPPAAPTYVPPSAASVPVASAPYFPSQPSHGLDDSTVQLAQKHARWAVSALTFDDVDTAIKELRNSLKCLGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W6PZ69</accession>
    <name>W6PZ69_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">1,4-alpha-glucan-branching enzyme</fullName>
            <ecNumber evidence="4">2.4.1.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Glycogen-branching enzyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">gbeA</name>
        <name evidence="13" type="ORF">PROQFM164_S01g002837</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Glycogen-branching enzyme participates in the glycogen biosynthetic process along with glycogenin and glycogen synthase. Generates alpha-1,6-glucosidic branches from alpha-1,4-linked glucose chains, to increase solubility of the glycogen polymer.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Transfers a segment of a (1-&gt;4)-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain.</text>
            <dbReference type="EC" id="2.4.1.18"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycan biosynthesis; glycogen biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.18" evidence="4"/>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PZ69"/>
    <dbReference type="STRING" id="1365484.W6PZ69"/>
    <dbReference type="OMA" id="YEMHLGS"/>
    <dbReference type="OrthoDB" id="196493at2759"/>
    <dbReference type="UniPathway" id="UPA00164"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003844">
        <property type="term" value="F:1,4-alpha-glucan branching enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043169">
        <property type="term" value="F:cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd11321">
        <property type="entry name" value="AmyAc_bac_euk_BE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02854">
        <property type="entry name" value="E_set_GBE_euk_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000001">
        <property type="entry name" value="1,4-alpha-glucan branching enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000250">
        <property type="entry name" value="1,4-alpha-glucan-branching enzyme, chloroplastic/amyloplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1180:FF:000003">
        <property type="entry name" value="1,4-alpha-glucan-branching enzyme, chloroplastic/amyloplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006048">
        <property type="entry name" value="A-amylase/branching_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037439">
        <property type="entry name" value="Branching_enzy"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004193">
        <property type="entry name" value="Glyco_hydro_13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43651">
        <property type="entry name" value="1,4-ALPHA-GLUCAN-BRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43651:SF3">
        <property type="entry name" value="1,4-ALPHA-GLUCAN-BRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02806">
        <property type="entry name" value="Alpha-amylase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02922">
        <property type="entry name" value="CBM_48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000463">
        <property type="entry name" value="GlgB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0320">Glycogen biosynthesis</keyword>
    <keyword evidence="6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="12">
        <location>
            <begin position="198"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="11">
        <location>
            <position position="345"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000463-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDM29026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="689" mass="78820" checksum="6C0508BA2591B0B1" modified="2014-04-16" version="1">MSSTIDSSNIPTDGTGVIQLDPWLEPYRDVLKHRYQVVEEWTKTINETEGSLDKFSKGYETFGLHAQPNGEIKYQEWAPNAKEASLVGDFNNWDVNANPMTKNSFGIWDVTVPAKNGAPAIPHESKIKITMVLPSGERIYRIPAWIKRVVQDLSVSPAYDAVFWNPPADEVYKFQYPRPKKPEDLRIYEAHVGISSPETRVATYKEFTKNMLPRIQYLGYNAIQLMAIMEHAYYASFGYQVNNFFAASSRYGSPEDLKELVDTAHEMGLIVLLDVVHSHASKNVVDGLNEFDGTDHLYFHGGAKGRHELWDSRLFNYGSHEVLRFLLSNLRFWMEEYQFDGYRFDGVTSMLYTHHGIGTGFSGGYHEYFGPGVDEEGVTYLTLANQMLHELYPDCITVAEDVSGMPALCLPHALGGAGFDYRLAMAIPDMWIKLLKESTDDEWDMANIAFTLTNRRHGEKTIAYAESHDQALVGDKTLMMWLCDKEMYTHMSTLTEFTPVIERGMALHKMIRLVTHALGGEGYLNFEGNEFGHPEWLDFPRAGNDNSFWYARRQLNLTEDPLLRYNFLNQFDRGMQLAEKKYKWLSSPQAYISLKNESDKVLVFERAGLLWIFNFNSKKSFTDYRVGIQVPGTYRIILDTDDTAFGGLGRNVKETRFFTTDMEWNGRANFVQVYIPTRTALVLALENTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>W6PZK3</accession>
    <name>W6PZK3_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Meiotic recombination protein DMC1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">DMC1</name>
        <name evidence="12" type="ORF">PROQFM164_S01g002968</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RecA family. DMC1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PZK3"/>
    <dbReference type="STRING" id="1365484.W6PZK3"/>
    <dbReference type="OMA" id="ANPMKPV"/>
    <dbReference type="OrthoDB" id="10251254at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000794">
        <property type="term" value="C:condensed nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070192">
        <property type="term" value="P:chromosome organization involved in meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000730">
        <property type="term" value="P:DNA recombinase assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042148">
        <property type="term" value="P:DNA strand invasion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000709">
        <property type="term" value="P:meiotic joint molecule formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006312">
        <property type="term" value="P:mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000056">
        <property type="entry name" value="Meiotic recombination protein DMC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000239">
        <property type="entry name" value="Meiotic recombination protein DMC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011940">
        <property type="entry name" value="Dmc1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016467">
        <property type="entry name" value="DNA_recomb/repair_RecA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010995">
        <property type="entry name" value="DNA_repair_Rad51/TF_NusA_a-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013632">
        <property type="entry name" value="Rad51_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020587">
        <property type="entry name" value="RecA_monomer-monomer_interface"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003301">
        <property type="entry name" value="PRK04301.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02238">
        <property type="entry name" value="recomb_DMC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22942:SF30">
        <property type="entry name" value="MEIOTIC RECOMBINATION PROTEIN DMC1_LIM15 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22942">
        <property type="entry name" value="RECA/RAD51/RADA DNA STRAND-PAIRING FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14520">
        <property type="entry name" value="HHH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08423">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005856">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47794">
        <property type="entry name" value="Rad51 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50163">
        <property type="entry name" value="RECA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0469">Meiosis</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecA family profile 1" evidence="10">
        <location>
            <begin position="95"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="RecA family profile 2" evidence="11">
        <location>
            <begin position="273"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDM29156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="338" mass="36787" checksum="E3D8498283B31C75" modified="2014-04-16" version="1">MPGSVGSDEFDDDEAFILDIDGIQAHGIGAADITKLKANGFYTVASVHGATRKTLLKIKGFSEVKVEKVKEAIQKCLPTASGFITAMELHHQRKKVVRISTGSKQFDSILNGGFQSMSISEVFGEFRCGKTQLSHTMSVIAQLPKEAGGASGRVAYIDTEGTFRPERIAQIAERFGMDPDTAQENISYARALNSEHQLELLNTLSQAFAGGEYRLLVIDSIMNCFRVDYCGRGELADRQQKLNQFLMKLAHMAEEFNVCVLMTNQVQSDPGASALFAGADGRKPVGGHVLAHASTTRVLLRKGRGEERVAKIQDSPDCAEREAIYIITNGGINDPDKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q0C2</accession>
    <name>W6Q0C2_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Oligopeptide transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PROQFM164_S02g000117</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM29968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q0C2"/>
    <dbReference type="OMA" id="DSYMGNV"/>
    <dbReference type="OrthoDB" id="8904098at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071916">
        <property type="term" value="F:dipeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000085">
        <property type="entry name" value="MFS peptide transporter Ptr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000109">
        <property type="entry name" value="POT_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018456">
        <property type="entry name" value="PTR2_symporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11654">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00854">
        <property type="entry name" value="PTR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01023">
        <property type="entry name" value="PTR2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="146"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="255"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="283"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="455"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="505"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="537"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="566"/>
            <end position="585"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM29968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="616" mass="67855" checksum="8F094B645A2BC07C" modified="2014-04-16" version="1">MNASDPVDVAEVAKSKAVSHTIGINEKGPVVDELTIDSAPPLRDASIEGDYSLDKTSPTDEELATLRRVAGKLPMAAYSVAFVELCERFSYYGTTAVFVNFIQRPLPTGSTTGALVPGVSNWSNDSPGALGMGQQASTGLTLFNSFWSYVMPLFGAMVADQYWGRYRTILSAIACALLGHTILIISAIPNVIASPNGAIACFSIGLIIMGVGTGGFKSNISPLIAEQYREDKPYVTTLATGERVIVDPSATVSRIYLYFYMMINIGSFVGQVAMVYAERYVGFWLSYLLPTAMFCVCPAVLIICKKQYILTPPSGSIYPKAFKVWKLAMKGHWTLNPVRWFRSSDTDMWAAAKPSNFGANKPAWMDFDDAWVDEVRRGLLACRVFLWYPLYWLAYNQMMNNLTSQAATMKLGGVPNDIINNLNPISLIIFIPIFDQLVYPCLRKMGFNFTPLKRITAGFIVASLSMVVAAVTQYYIYKLGPCGNEANYCLEVKHEYTNISVWVQALTYIMGGISEILASVTSLEYAYTKAPKNMRSLVQAVSLLMNAFSSAIGQAFIGLAEDPLLTWNYTVVAILAFVGGIGFWATNYKLDAEEDSMNMLPDSEFTPHTVVDEERK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q0U2</accession>
    <name>W6Q0U2_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transcription factor, MADS-box</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PROQFM164_S02g000064</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM29915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q0U2"/>
    <dbReference type="STRING" id="1365484.W6Q0U2"/>
    <dbReference type="OMA" id="TPLHENK"/>
    <dbReference type="OrthoDB" id="1898716at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1810.10">
        <property type="entry name" value="Transcription factor, MADS-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002100">
        <property type="entry name" value="TF_MADSbox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036879">
        <property type="entry name" value="TF_MADSbox_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00319">
        <property type="entry name" value="SRF-TF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55455">
        <property type="entry name" value="SRF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="MADS-box" evidence="6">
        <location>
            <begin position="24"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM29915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="103" mass="11855" checksum="A671A841A1B93972" modified="2014-04-16" version="1">MAAIKATRSKHVTSKIKLIRQKQCRRKTSLMKKACEYSRMCSADVCVGIRMRETGQVHILSADASGFWAFLTSQLSSHYPTPTVMTDRDLEKTREETVFREQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q1H6</accession>
    <name>W6Q1H6_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA polymerase epsilon subunit D</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">DNA polymerase II subunit D</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PROQFM164_S02g000542</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q1H6"/>
    <dbReference type="STRING" id="1365484.W6Q1H6"/>
    <dbReference type="OMA" id="NTYRRKV"/>
    <dbReference type="OrthoDB" id="1707486at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008623">
        <property type="term" value="C:CHRAC"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008622">
        <property type="term" value="C:epsilon DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031507">
        <property type="term" value="P:heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006272">
        <property type="term" value="P:leading strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22928">
        <property type="entry name" value="HFD_POLE3_DPB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051377">
        <property type="entry name" value="DNA_Pol-Epsilon_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46172">
        <property type="entry name" value="DNA POLYMERASE EPSILON SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46172:SF1">
        <property type="entry name" value="DNA POLYMERASE EPSILON SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor CBF/NF-Y/archaeal histone" evidence="7">
        <location>
            <begin position="56"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="140"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="194"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="223"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="249"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00039775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00042096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM30393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="272" mass="29774" checksum="6ECCF4940BDF716D" modified="2014-04-16" version="1">MPPRKSTSSVTPADPDDSLLQHSSPVAHTDKPVFATEQQLKARAEAGASVEDYLLPRSLTIRLAKSVLPPNTTIQKDAVLAMQKAATVFVSYLSSHANDATLKRTIAPSDVFNALSELELDSFRGRLEQELEAYMEIKAGKRKPKKADENGSTEDALGEGATQADADVDMLDNPAKRVKRGVSVEKAVGPTAGDDGDETQEEDVEEEEEEEDETEEEEEEEDRTPREDNLEHVEDLDREPGARRGPYDPDAEETDEDEDGPGSQLRDDLGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q1L4</accession>
    <name>W6Q1L4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta hydrolase fold-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g003664</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q1L4"/>
    <dbReference type="STRING" id="1365484.W6Q1L4"/>
    <dbReference type="OMA" id="WAMDGAD"/>
    <dbReference type="OrthoDB" id="8119704at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050266">
        <property type="entry name" value="AB_hydrolase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798:SF33">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G14860)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798">
        <property type="entry name" value="MONOACYLGLYCEROL LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="73"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM29851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="313" mass="34765" checksum="0F91D48E12BBE669" modified="2014-04-16" version="1">MLSRLTGFPGCLLPTPRISGDLRDRRSCTDIRWHHQGRHTVGEKLEAPHWSSYHFAMSLELYHTAHNAGQTTVVLIHGALVSGLYWDLVIPHLTSYRLLVPDLPGHGNSASAPFSVDLAARQIAQLIRIHANGSAHIVGHSLGAQVAIRLACTEPDVVNSVFISGFRMFPQTSLTPYIPYAVWVMLRVENCLSRPLISWAMDGADIPRIDTNLGTLDLCRQIVSPEHPTQWPSPWPARTLIVAAGKGGLVPTKDSPGDAVKLMAIGRELNEETIAYTHLKMRHPWNRQDPRLFAETAAAWFEHKELPEGFVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q1U7</accession>
    <name>W6Q1U7_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">galacturonan 1,4-alpha-galacturonidase</fullName>
            <ecNumber evidence="12">3.2.1.67</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Galacturan 1,4-alpha-galacturonidase B</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Poly(1,4-alpha-D-galacturonide)galacturonohydrolase B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">pgxB</name>
        <name evidence="18" type="ORF">PROQFM164_S02g000110</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Specific in hydrolyzing the terminal glycosidic bond of polygalacturonic acid and oligogalacturonates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>[(1-&gt;4)-alpha-D-galacturonosyl](n) + H2O = alpha-D-galacturonate + [(1-&gt;4)-alpha-D-galacturonosyl](n-1)</text>
            <dbReference type="Rhea" id="RHEA:14117"/>
            <dbReference type="Rhea" id="RHEA-COMP:14570"/>
            <dbReference type="Rhea" id="RHEA-COMP:14572"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58658"/>
            <dbReference type="ChEBI" id="CHEBI:140523"/>
            <dbReference type="EC" id="3.2.1.67"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the glycosyl hydrolase 28 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.67" evidence="12"/>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM29961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q1U7"/>
    <dbReference type="STRING" id="1365484.W6Q1U7"/>
    <dbReference type="OMA" id="CRNVVNV"/>
    <dbReference type="OrthoDB" id="187139at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047911">
        <property type="term" value="F:galacturan 1,4-alpha-galacturonidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000040">
        <property type="entry name" value="Probable exopolygalacturonase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000743">
        <property type="entry name" value="Glyco_hydro_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31736">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31736:SF6">
        <property type="entry name" value="EXOPOLYGALACTURONASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00295">
        <property type="entry name" value="Glyco_hydro_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 16" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 17" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004879861" description="galacturonan 1,4-alpha-galacturonidase" evidence="17">
        <location>
            <begin position="19"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00041473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00042261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU361169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CDM29961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="437" mass="47886" checksum="9B45B0DF5DAFE791" modified="2014-04-16" version="1">MKFIAIGAVLFSAVGAFATERIIKGAQIIPANDKLGLKKIGAYGHHKHDDRRTVTIRSSKSDTDDISYDFLWGIKAANHGGRLLLQKGKTYVIGKKLDLSFLNNIEVQLEGEVKFTDDIDYWQANHFYYSFQKSITFWVWGGQDIKIFGKGILNGNGQEWYNAFSGLEVLDPDNTFYRPILFVTDNATRVSVEGITQLNSPCWTNFFVRTKDVSFDDVFINAFSTNASALPKNTDGFDSFNVDGLSVTNTRVDIGDDCFSPKPNTTNIFVQNLWCNNTHGVSMGSIGQYSGVEDIIENAWVENVTLLNGQNGVRLKAWAGPDIGFGRINNITYKDIHIENTDAPIVLDQCYFDVNATTCAEYPSSVNFTNITFENIYGTSSGKNGKVIGDLTCSPNAVCSGIHLSDIDIVSPAGGPPVVTCDGIDGDIGVECQSSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q292</accession>
    <name>W6Q292_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S02g000813</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q292"/>
    <dbReference type="STRING" id="1365484.W6Q292"/>
    <dbReference type="OMA" id="QSVPDWF"/>
    <dbReference type="OrthoDB" id="202825at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="239"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="319"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="104"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="239"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="319"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM30663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="538" mass="60272" checksum="F5AD6A0F2136BFCD" modified="2014-04-16" version="1">MPGHVCILSFYSQPVGGSSFTTSHDLFEPIDKMTTISTSKLSVTPPTQLQLALALAVVKGKPPGQSVKEYILQIRHFIKKTKDLGQIVATDKFFDSVSFWQQAYERSEAGQSKLQDQVHELNQRIEGLLVKLRVNGTANDNESLPANKRKASAVGKNTNSSNMAKKRIKLPKNMQKSIPLMDDDDSGEEDVLCLNRHLHTVQKALQRRTTSSSEANSLAVKAVILCKSAEQKLIQTIQRESSMTEQKPSQTGQANMPDTHDVMNGVTVAFHLTHKALHKIGGAKNRMQHQGQVIYYLVGLFESTMRALTLHCTSISKQKPVTKNTKSSGDPKPTTQPEEQSKRPKANSLATKNEITFRLADLLCTMALSLNLTRTEDQEVMEGFLFLVIDRMGKMLALHVFHDLRLPMGICPGMTFPDGLEAMTDECLGPNEAQLEAKYLIRLLDRMLNAESRQSPLEASAARQFVTKAKDRLQKSLLRAVFGPDDHLFREGLRRPHTPPPQVLENKQMDQREFSDWLTQELWRLVGWDVLRTVVAPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q2L5</accession>
    <name>W6Q2L5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S02g000913</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q2L5"/>
    <dbReference type="OMA" id="DGITVKW"/>
    <dbReference type="OrthoDB" id="4358391at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM30763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="141" mass="15201" checksum="671397905EF22389" modified="2014-04-16" version="1">MSLQNTIPAESYSGTLDGISFFWSPNAIFNLPGSAATYQAELNVLKSATEQVAVACARRIGKTSVRILGYDSTTVTGSGETKPDPCHCSLFLNPGGTKAHIYVTSPRRVRIENMRVLGESIIPKGSRIRDPNLSFGDLPPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q336</accession>
    <name>W6Q336_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PROQFM164_S01g002425</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM164</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q336"/>
    <dbReference type="STRING" id="1365484.W6Q336"/>
    <dbReference type="OMA" id="THAWISE"/>
    <dbReference type="OrthoDB" id="203237at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11041">
        <property type="entry name" value="CYP503A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007213">
        <property type="entry name" value="Ppm1/Ppm2/Tcmp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206:SF1">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04072">
        <property type="entry name" value="LCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0349">Heme</keyword>
    <keyword evidence="8 10" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="24"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="10">
        <location>
            <position position="502"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDM28614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="836" mass="95115" checksum="2636F326B3A05221" modified="2014-04-16" version="1">MSFHSTVLGVDVSTRHMVGAMESFVLGITTNHIIGALGIFILTLLVAKWDQGVLSDSLPQVGYGKGFLATIQNFLLAYARHKVWVEEGYEKYTKNNRPFIVPWGFGRRSAVVLPQSQIRWLLEQSDEVISADEANNDSLYARYNFLGNAHPQDPFNNRAIGRNLIRALGELTPGMQEEVQDSIDREFGLDTQKWKSLNIWDMWLGLIPQITNRMVLGKDLGRNSKLLSSMVGFTESVLRNVFLLDFLPRSLHPLLGPLLAIPNWFHHRRAIRMTLPVIQKRLMDMERKANGDPAYNSWTEPEDFITWCIRQARLEGDLTELKASKIAQRTLLVEVASIHTTAMTAQNAMIDILAAGPSVLEALREEADRVFREENYQWSKAGLAKLYRIDSAIRESQRRSNFAVTLLDHKVIAREGITHKDEGWHIPYGSTLTLNLNGIYHDPDLYENPESYDAFRYSRPIEEYAAQSDGSKDPAEGEKYRKMGMVTTSETHLIFGHGRHACPGRFFVAHELKLAIAYMVLNYDLKNIAERPAPTVMGNFILPSFRIQMQIRRRDNNVRAPSADNKKIHLTGAQETMLGTLLGRFKDAQHPQPILNDLWAGRILDQIDYDFAKLKMDRMQFSAICMRSRTFDRWTTEFIERHEDTGATVICLACGLDSRSLRLQWGPKVRWIDLDLPDVVALRRKLLPTPGGDYRLVDASVMEDAWLQDIPADRPTLILLEGLVMYLTEEEGKGLLQRLVERFPSGQLIFDAVGSIMIAVQHRSQIAKATGTSMYWGLDQPQALEALAPRLRLRDIARFGDQDGANELPLLVRCVAWALSHVPYIRDVGYVLRYEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q4X8</accession>
    <name>W6Q4X8_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ATP citrate synthase</fullName>
            <ecNumber evidence="4">2.3.3.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PROQFM164_S02g001535</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>oxaloacetate + acetyl-CoA + ADP + phosphate = citrate + ATP + CoA</text>
            <dbReference type="Rhea" id="RHEA:21160"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.3.3.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the C-terminal section; belongs to the succinate/malate CoA ligase alpha subunit family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.8" evidence="4"/>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q4X8"/>
    <dbReference type="STRING" id="1365484.W6Q4X8"/>
    <dbReference type="OMA" id="DMHVSGI"/>
    <dbReference type="OrthoDB" id="5295093at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042709">
        <property type="term" value="C:succinate-CoA ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003878">
        <property type="term" value="F:ATP citrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004775">
        <property type="term" value="F:succinate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006104">
        <property type="term" value="P:succinyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.261:FF:000004">
        <property type="entry name" value="ATP-citrate synthase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.110:FF:000003">
        <property type="entry name" value="ATP-citrate synthase subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032263">
        <property type="entry name" value="Citrate-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056749">
        <property type="entry name" value="Citrate_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11815:SF10">
        <property type="entry name" value="SUCCINATE--COA LIGASE [GDP-FORMING] SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11815">
        <property type="entry name" value="SUCCINYL-COA SYNTHETASE BETA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16114">
        <property type="entry name" value="Citrate_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24948">
        <property type="entry name" value="Citrate_synth_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ATP-citrate synthase ATP-grasp" evidence="15">
        <location>
            <begin position="2"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-citrate synthase citrate-binding" evidence="14">
        <location>
            <begin position="297"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF16114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF24948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CDM31385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="485" mass="52560" checksum="CD0D0056A679D854" modified="2014-04-16" version="1">MSAKSILEADGKAILNYHLTRAPVIKPTPLPASATHNPPARLASLHFPEDKAVKDVLDQAEVSFPWLLTPGAKFVAKPDQLIKRRGKSGLLALNKTWAEARDWIEARATKDVQVETVTGVLRQFLVEPFVPHPQETEYYININSVREGDWILFTHEGGVDVGDVDAKAEKLLIPVNLKQYPSNEEIAATLLSKVPKGVHNVLVDFISRLYAVYVDCQFTYLEINPLVVIPNADATSAEVHFLDLAAKLDQTAEFECGTKWAVARSPAALGSPVLASTSGKVSIDAGPPMEFPAPFGRELTKEEKFISDMDAKTGASLKLTVLNASGRVWTLVAGGGASVVYADAIASAGFVSELANYGEYSGAPTETQTFNYARTVLDLMLRAPAHPEGKVLFIGGGIANFTNVASTFKGVIRALREVANLLNEHKVQIWVRRAGPNYQEGLKNIKSVGIELGLDMHVYGPEMHVSGIVPLALQGKKTDIKEFGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q557</accession>
    <name>W6Q557_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S02g001914</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q557"/>
    <dbReference type="OMA" id="RTHEQFH"/>
    <dbReference type="OrthoDB" id="4932058at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004879594" evidence="1">
        <location>
            <begin position="25"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM31763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="291" mass="32129" checksum="DC7EFF5290C584F1" modified="2014-04-16" version="1">MFFQRSSLLAFISLHLGFIPRTAGQVQANCLSQQILNNDLNNCICAGGNNECQKQCPVGPVAPVMPAPNCGSHLLGHLHLDDCEHHCLTESNDFCKSCWIWNLPLCLCLQNGGCLQSSKNAPYWVKITSTLATTNLAIPDILNLQENHKLLAGYGWDFGQETASDPKTESLVINSAYSITENQIHMHVCNINTKMRDWLATLYQSSPSAYQTLVEIPPPYPAGEKMFCRASQTADQTIPGDSISDDINSVIQQQPVCKYFVGAAVIRDSKHYTWVCVTADHLSAEYGRFCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q5G4</accession>
    <name>W6Q5G4_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">COP9 signalosome complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">csnB</name>
        <name evidence="11" type="ORF">PROQFM164_S02g002054</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM164</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4">Component of the COP9 signalosome (CSN) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CSN2 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q5G4"/>
    <dbReference type="STRING" id="1365484.W6Q5G4"/>
    <dbReference type="OMA" id="SEENWKD"/>
    <dbReference type="OrthoDB" id="194139at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.570:FF:000006">
        <property type="entry name" value="COP9 signalosome complex subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050871">
        <property type="entry name" value="26S_Proteasome/COP9_Components"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10678">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 11/COP9 SIGNALOSOME COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00753">
        <property type="entry name" value="PAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0736">Signalosome</keyword>
    <feature type="domain" description="PCI" evidence="10">
        <location>
            <begin position="252"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="449"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="451"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDM31903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="488" mass="56171" checksum="FF49A4DBD6C4528C" modified="2014-04-16" version="1">MSDDDDFMQDSADEDYDFEYEDADDDDSGDIGIENKYYNAKQIKVDNPEEAVDEFLGIAPMEQDKGDWGFKGLKQAIKLEFKLGRYSDTVAHYRELLTYVKSAVTRNYSEKSINNMLDFIEKGSDNAEAYQCMEEFYSLTLESFQNTNNERLWLKTNIKLARLWLERKQYGQLAKKMRELHRACQREDGSDDTSKGTYLLELYALEIQMSSETKNNKRLKALYERALRVRSAVPHPKIMGIIRECGGKMHMSEENWKEAQSDFFESFRNYDEAGSMQRIQVLKYLVLTTMLMKSDINPFDSQETKPYKNDPRISAMTDLVDAFQRDDIHAYEDVLSKNPDVLADPFIAENIDEVSRNMRTKAVLKLIAPYTRFSLQFISKHIKVSVPEVLDILSFLILDKKLNAKIDQDNGTVVVESASDVERLRAVGEWSSALRTLWQTTLNGEGLRANEPSQGSIFQSSLGDEGMRPTAPRARKDGRGKMPTKWLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q5I9</accession>
    <name>W6Q5I9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S02g001750</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q5I9"/>
    <dbReference type="STRING" id="1365484.W6Q5I9"/>
    <dbReference type="OMA" id="DTKYRLT"/>
    <dbReference type="OrthoDB" id="4524525at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM31600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="279" mass="31984" checksum="128DFBAE0EA4A22F" modified="2014-04-16" version="1">MVPSREVEKSDFGNFPTDMVMLVSIIKESDTKYRLTGINILNHSAESPYYTPNDPEMARIGGRKGTAPDQVGNEDFTEFYGTSIGRQPSQYKGKVVGYIIHASCWVLFNQVEGLKLKEAKLAKLVQVCRKHWRKNTMWRLYDNNLRISSRSSNIPLEVAILIAEWVCPIKHTLSDIKNTGNMLLVFGWNLPDWFWQRRLDEGLFIELDKLKKEMSPVGWQLRLNLMCLVVGRTEFRSSSGLASRERVLKSILALEKPYLTLESAKEKALIEKGKKNESQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q5P7</accession>
    <name>W6Q5P7_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="17">DNA repair protein (XPGC)/yeast Rad</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PROQFM164_S02g002164</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">FM164</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the XPG/RAD2 endonuclease family. EXO1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q5P7"/>
    <dbReference type="STRING" id="1365484.W6Q5P7"/>
    <dbReference type="OMA" id="DCRSRFF"/>
    <dbReference type="OrthoDB" id="26491at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035312">
        <property type="term" value="F:5'-3' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09908">
        <property type="entry name" value="H3TH_EXO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09857">
        <property type="entry name" value="PIN_EXO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000011">
        <property type="entry name" value="exonuclease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000002">
        <property type="entry name" value="Exonuclease 1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037315">
        <property type="entry name" value="EXO1_H3TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008918">
        <property type="entry name" value="HhH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044752">
        <property type="entry name" value="PIN-like_EXO1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006086">
        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019974">
        <property type="entry name" value="XPG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006085">
        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081:SF65">
        <property type="entry name" value="DNA DAMAGE-INDUCIBLE PROTEIN DIN7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081">
        <property type="entry name" value="FLAP ENDONUCLEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00867">
        <property type="entry name" value="XPG_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00752">
        <property type="entry name" value="XPG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00279">
        <property type="entry name" value="HhH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00484">
        <property type="entry name" value="XPGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00485">
        <property type="entry name" value="XPGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00841">
        <property type="entry name" value="XPG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0267">Excision nuclease</keyword>
    <keyword evidence="8" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XPG N-terminal" evidence="16">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="XPG-I" evidence="15">
        <location>
            <begin position="138"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="366"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="477"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="513"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="602"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="696"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="384"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="528"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="559"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="602"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="620"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="705"/>
            <end position="715"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CDM32013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="733" mass="81248" checksum="91339CC654466EDE" modified="2014-04-16" version="1">MGIKGLHGLLKSIQKPCHIKNFNGQTLGVDAYGWLHRGTVACSVDLVLDNPTRKHIDFVLNRVRMLLFFGVKPYLVFDGDNLPSKAGTEQDRYRRRQESKCLGLELQRKGRMAEAYQEFQKAVDVTPYMARQLIEELKQMNVQYVVAPYEADAQLVYLEQQGDIHGIISEDSDLLVFGAKRLISKLDQHGECIEINRADFTACREVSLVGFSDPDFRNMCILSGCDYLANIPKLGLKTAYRIIRKHRSVEKALRMLQFEGNFRVPADYLANFKQAELTFLYQRVFCRKAEKLVTLTPPDKDTNLAALPYIGADMEPEIAIGVSRGDLDPTTKEPITLKPLAAGRWSLGINRRQTLGTSSELKPKKSINSFFTPKRTPLAELDPNSLTPSPSQQRLLERNASNSWQANAAPFRSNSVRSTPLRAFSDQGLSPMVRSVERSSFLAQSARSSALQCTKRQRLCSEAEGDSLPACPPARSRFFAQASPSPQDLSRSKRSRKSVIGVFSDEIAEDIMCSIPDPSTTPGPAESTTERNLEISDKPSEVDTPSKPTSDKVLVTENLDVSQNSPRDNTPNSPGFSLALDYHVDRQNSNLLSKFTFQAGQKPETTAASSTMTKIPAAQTSHRPSTPSTPRSPAAIARSNVFHRRLTPLQRMGQSALSRSHSINIPTKLRDAEAVEPRTEASSPIVHKVSSLAGIQGSEDLIVPDSEDEEDEDEPSTGYSTTLDLKRFAFAAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q5V8</accession>
    <name>W6Q5V8_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein-serine/threonine kinase</fullName>
            <ecNumber evidence="7">2.7.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PROQFM164_S01g003441</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the PDK/BCKDK protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.-" evidence="7"/>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q5V8"/>
    <dbReference type="STRING" id="1365484.W6Q5V8"/>
    <dbReference type="OMA" id="ICEAQEH"/>
    <dbReference type="OrthoDB" id="407390at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004740">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010906">
        <property type="term" value="P:regulation of glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.20">
        <property type="entry name" value="Alpha-ketoacid/pyruvate dehydrogenase kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036784">
        <property type="entry name" value="AK/P_DHK_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018955">
        <property type="entry name" value="BCDHK/PDK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039028">
        <property type="entry name" value="BCKD/PDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11947:SF25">
        <property type="entry name" value="[PYRUVATE DEHYDROGENASE (ACETYL-TRANSFERRING)] KINASE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11947">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10436">
        <property type="entry name" value="BCDHK_Adom3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69012">
        <property type="entry name" value="alpha-ketoacid dehydrogenase kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Branched-chain alpha-ketoacid dehydrogenase kinase/Pyruvate dehydrogenase kinase N-terminal" evidence="10">
        <location>
            <begin position="46"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase/HSP90-like ATPase" evidence="9">
        <location>
            <begin position="262"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="355"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="355"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF10436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDM29629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="435" mass="49621" checksum="274503657FD6F412" modified="2014-04-16" version="1">MRLSYPARRWQLLQSPLKRLYSGAHSPPPWRPVSAVDEWVERAIRPISLRQLTFFGRTLTEPRLISSANYVRTELPTRLAHRLRDIQQLPYVVVANPHLTLVYELYYKAFERARVVPEIKTLDDNDRFCDILKEMLREHLVAIPNLAIGVLECRNLAPADEMDRLMNTLLRARISRRVIAEQHLALTETFNSPWHFPDSHDRTDINAEFVGEVFLKCKAKEVIEDCGKVAQDLMKKISGSTQIPAIVVKGHADATFPYILSHLEYIIGELLRNSVQAVMERYQDSTEPPPPIEVLVCETPQHVIMRISDQGGGIPREILPYLWSFSKGPRTQTRLENLGQVPAMAATMQELQVSHDRKHTDRESYHEGSLDTLTSRPPNLRLGMGLPMSRVYAEYWAGSLELHSLEGYGVDAFLQFSKLGNKNEQVTTRAAIDAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q689</accession>
    <name>W6Q689_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">alpha-glucosidase</fullName>
            <ecNumber evidence="3">3.2.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PROQFM164_S02g001676</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing (1-&gt;4)-linked alpha-D-glucose residues with release of alpha-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.20"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.20" evidence="3"/>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q689"/>
    <dbReference type="STRING" id="1365484.W6Q689"/>
    <dbReference type="OMA" id="IDWEYTP"/>
    <dbReference type="OrthoDB" id="1334205at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004558">
        <property type="term" value="F:alpha-1,4-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14752">
        <property type="entry name" value="GH31_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1760">
        <property type="entry name" value="glycosyl hydrolase (family 31)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025887">
        <property type="entry name" value="Glyco_hydro_31_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31_TIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762">
        <property type="entry name" value="ALPHA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762:SF165">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G06560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13802">
        <property type="entry name" value="Gal_mutarotas_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 31 N-terminal" evidence="7">
        <location>
            <begin position="130"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 31 TIM barrel" evidence="6">
        <location>
            <begin position="254"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="487"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="490"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM31526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="512" mass="57083" checksum="AC624B911211AB80" modified="2014-04-16" version="1">MPQREVCPKGYSQVPQATDQEASVHLRSSTKSKSAFDFTFEAIRPNLFRATFASTEHPIPPYPSVTKPEINLQGANVFTKEGPSSKTIDVAGVTASIDWEYTPVVKLSWIGSEKPLHKDLSLRSYIVDGEGVANYSVHDRECLHVGLGEKAAPMDLTGRQFQLSATDSFGYDVYNTDPLYKHIPLLIKASAEGCVAIFSTTHSRGLWSVGAEIDGLWGHFKVYRQDHGGIEQYYIVGKTIKDVVRSYAELVGFPILVPRWAYGYISGGYKYTMLDEPQKAHLALLEFAEKLKQHGIPCSAHQMSSGYSIAETEPKVRNVFTWNRERFPDPQDWIAKMHQYGIRLLTNIKPFLLASHPDFQKLVDAGGFFKDAENQPGYMRLWSAGGATGGDGAHIDFTSAEAFKWWYDGVQSLQKVGIDGMWNDNNEYTLPDDDWTMSLNEPTVADAAAKDVKNSVGLWGRALHTELMGKSSHDALQDMEPKLRPFVLTRSATQDSQAKPPTPGDRHLRNTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q773</accession>
    <name>W6Q773_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Six-bladed beta-propeller, TolB-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S02g000258</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q773"/>
    <dbReference type="STRING" id="1365484.W6Q773"/>
    <dbReference type="OrthoDB" id="9977941at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052998">
        <property type="entry name" value="Hetero-Diels-Alderase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42060">
        <property type="entry name" value="NHL REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42060:SF3">
        <property type="entry name" value="SMP-30_GLUCONOLACTONASE_LRE-LIKE REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM30109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="147" mass="15995" checksum="F10B3D4DFD038775" modified="2014-04-16" version="1">MAANHDMGLLLEVNGLKIVNEYMYYSNSPEHIFCRVQIDTHTGRALGPYEVISHDILADDFAIGLHGVGYLAGLVDDVVIRAFPNRYHELIAGLKGSMDLMTATSAAFGRTQRYRNVLYITTGGGTKLPVDDTSTRGGKVMAVSVGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q7D3</accession>
    <name>W6Q7D3_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S02g002396</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q7D3"/>
    <dbReference type="STRING" id="1365484.W6Q7D3"/>
    <dbReference type="OMA" id="PFRWKHP"/>
    <dbReference type="OrthoDB" id="3363286at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="61"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM32245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="415" mass="45966" checksum="92F435CAEE8D2CB5" modified="2014-04-16" version="1">MECVGTRIPYAKWRLSAFRQLLATSHAQAVNRGIATSRKTNQPNETTLEKETDNSTPETAPPSQRLPQSPLLTHPRSGIEKNRKRRPTTQEEADLLKNPWALMLASPARMCSVTGARLPSALLGTWGLIRQPTSDDLYMIPVGLLQDSLQSNKTKNLSSSPEPTIPDQQETKSMAIQGQEKGPLIASPIPKSSDKRTGRQLVIRIAELLPLIRSISVPLSRKGGKRPAIMRLLPFRWKHPQGPVKANDEKRIVWSKDTPKLMLRSMRDVVVKKLSAVLEKYKRVDTSNGVWKALDLPEYSDAALKEALGSLEPFERMECGAVLLLGSQNSAAADHGSQSSSSLDSVALTQTGSKVPVFDLSVLLSESDINKLRESHGQFQHTALFFRPEEQLGIDAMISLWKIKRLLNGVDPIEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q8E7</accession>
    <name>W6Q8E7_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S02g002806</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q8E7"/>
    <dbReference type="OrthoDB" id="10293956at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM32655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="110" mass="12419" checksum="B5DD2DFEDCC032AC" modified="2014-04-16" version="1">MLYASNKGILYTTGEMVWCVLKALVRPPARSPAAPVGDCSRALLIQDKLRMSLNTLSWNLRLSNLQSRSMILARRISIPHKARSFILLLRWVVEPLRDDTTEKSKGRAKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q980</accession>
    <name>W6Q980_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S01g000106</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q980"/>
    <dbReference type="OMA" id="NAWDMES"/>
    <dbReference type="OrthoDB" id="4337159at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM26297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="166" mass="18613" checksum="B4C3BE650250A245" modified="2014-04-16" version="1">MSAAQCTRLIARNIPQVRRQRQLPNPRVTLVGSPAPSRNPTIDSEVLPYRLYELSLKKIRKEAHAAEPDLRHVIAGITMQKVVSSAVHDDLLHRVDLIENAKLPTTLPILPGADEPWEHEEVAPNQISNPNAWDMESLDQALCEMERASKKGNIAKIVCFQLISEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q9A8</accession>
    <name>W6Q9A8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S02g002752</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q9A8"/>
    <dbReference type="STRING" id="1365484.W6Q9A8"/>
    <dbReference type="OMA" id="QACEENT"/>
    <dbReference type="OrthoDB" id="4460251at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM32601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="116" mass="13291" checksum="4077C30F51DFC3D1" modified="2014-04-16" version="1">MRENSRFLAVGFVGASKVENRHFNNNPQKMENAAENLTSRALTPDLRHSVKRRVIVKRVIPTQDFPISRLQSAREVFSSQQACEENTRLKSIYETNKPALLCCDMKLYIGDHVESI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q9F2</accession>
    <name>W6Q9F2_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">3-methyl-2-oxobutanoate hydroxymethyltransferase</fullName>
            <ecNumber evidence="3 6">2.1.2.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">panB</name>
        <name evidence="7" type="ORF">PROQFM164_S01g000206</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + 3-methyl-2-oxobutanoate + H2O = 2-dehydropantoate + (6S)-5,6,7,8-tetrahydrofolate</text>
            <dbReference type="Rhea" id="RHEA:11824"/>
            <dbReference type="ChEBI" id="CHEBI:11561"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantoate from 3-methyl-2-oxobutanoate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the PanB family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.11" evidence="3 6"/>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q9F2"/>
    <dbReference type="STRING" id="1365484.W6Q9F2"/>
    <dbReference type="OMA" id="MGMEDTN"/>
    <dbReference type="OrthoDB" id="425211at2759"/>
    <dbReference type="UniPathway" id="UPA00028">
        <property type="reaction ID" value="UER00003"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003864">
        <property type="term" value="F:3-methyl-2-oxobutanoate hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06557">
        <property type="entry name" value="KPHMT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.60:FF:000003">
        <property type="entry name" value="3-methyl-2-oxobutanoate hydroxymethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00156">
        <property type="entry name" value="PanB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003700">
        <property type="entry name" value="Pantoate_hydroxy_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00222">
        <property type="entry name" value="panB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001452">
        <property type="entry name" value="PRK00311.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20881">
        <property type="entry name" value="3-METHYL-2-OXOBUTANOATE HYDROXYMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20881:SF0">
        <property type="entry name" value="3-METHYL-2-OXOBUTANOATE HYDROXYMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02548">
        <property type="entry name" value="Pantoate_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-0566">Pantothenate biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6 7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM26397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="336" mass="36220" checksum="66950E436199BAB4" modified="2014-04-16" version="1">MTLKPVNCLRRPALHCRNLAVPLRQSPIKTCAQYSSHSPIGSTTTSTRKKVTIQTIQNLYKKNEPITVLTASDFPSGHVADTAGMEIVLVGDSLAMVAMGMEDTNEVTMDEMLLHCRSVNRAVKSAFTIADLPMGSYETTPEKALTSAIRMVKEGGMKGVKLEGGAEMASTIRKISQAGIPVMAHIGLTPQRQHSLGGFRVQGKSAAGAVKLLRDALAVQKAGACVVLIEAVPPEIAGIVTRRLSVPTIGIGSGNGCSGQVLVQVDMLGNFPEGRFLPKFVKTYADVWGEARRGIEAYREEVKSRAFPSVEYTYGVSKEVLEEFEKVVDEVAENEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W6QAJ4</accession>
    <name>W6QAJ4_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">fumarate reductase (NADH)</fullName>
            <ecNumber evidence="7">1.3.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">NADH-dependent fumarate reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PROQFM164_S02g003207</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>succinate + NAD(+) = fumarate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18281"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.3.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.6" evidence="7"/>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM33056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QAJ4"/>
    <dbReference type="STRING" id="1365484.W6QAJ4"/>
    <dbReference type="OMA" id="EDLWVVV"/>
    <dbReference type="OrthoDB" id="10252157at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016156">
        <property type="term" value="F:fumarate reductase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.700.10:FF:000007">
        <property type="entry name" value="NADH-dependent fumarate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-dep_OxRdtase_2_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050315">
        <property type="entry name" value="FAD-oxidoreductase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010960">
        <property type="entry name" value="Flavocytochrome_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01813">
        <property type="entry name" value="flavo_cyto_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43400">
        <property type="entry name" value="FUMARATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43400:SF1">
        <property type="entry name" value="FUMARATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="9">
        <location>
            <begin position="538"/>
            <end position="614"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00050832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00067004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00077246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDM33056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="622" mass="66794" checksum="5A9A2334B124053D" modified="2014-04-16" version="1">MAAPQVIVVGGGLSGLSAAHTVYLNGGNVLVLDKQAFFGGNSTKATSGINGALTRTQVDLGIQDSVKQFYDDTLKSARDKARPDLIKVLTYKSAAAVEWLQDVFNLDLTLVSRLGGHTFPRTHRGHDAKFPGMAITYALMQRLEDLAEKEPSRVQIIKKADVTSVNKSGNNVTGVTYTVDGEKKVADGVVILATGGYAADFSETSLLKKYRPDTYGLSSTNGTHATGDGQKMLMAIGANGIDMDKVQVHPTGLVDPKDPGAKFKFLAAEALRGEGGLLLNCDGQRFSDELGHRDYVSGKMWEEKEKGKWPIRLVLNSKASKVLDFHTRHYTGRGLMKKMTGAELVAEIGCGEAALKKTFDEYNLIAEGKKKDPWNKRFFANMPFKLDDEFHVSVMEPVLHFTMGGIEINEHAQVLNSEEKPFEGLYACGELAGGVHGANRLGGSSLLGCVVYGRVAGDSATQHLLQKLLSNGGGAASQRLGQLSLHIDPNTPGKISVEWGSGATGGSLPALPVPAAAPAASAEAPAPKPDPATFKVPETEYSMDEVAEHNTKKDFWVVVKGVILDLTNWVDEHPGGANALYNFMGRDATEEFAMLHDDEVIPKYAAQTVIGRVKGQTPSLEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W6QBP5</accession>
    <name>W6QBP5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Oligoribonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">orn</name>
        <name evidence="6" type="ORF">PROQFM164_S03g000599</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oligoribonuclease family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QBP5"/>
    <dbReference type="STRING" id="1365484.W6QBP5"/>
    <dbReference type="OMA" id="AFFHYRN"/>
    <dbReference type="OrthoDB" id="270189at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06135">
        <property type="entry name" value="Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000003">
        <property type="entry name" value="Oligoribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022894">
        <property type="entry name" value="Oligoribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003765">
        <property type="entry name" value="PRK05359.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11046">
        <property type="entry name" value="OLIGORIBONUCLEASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11046:SF0">
        <property type="entry name" value="OLIGORIBONUCLEASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuclease" evidence="5">
        <location>
            <begin position="44"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDM33875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="222" mass="24909" checksum="C2E2C2C8CD98EF97" modified="2014-04-16" version="1">MLRSIFLRASAFRGVLVQPGFLHQPGRAPIRYKSTMPLERSTDPLVWIDCEMTGLNPETDKIIQICCFITDAQLNLLEPTGFETVIHVPDSALDAMSQWCIDTHGRTGLTAAVRASTTSPSTAADSLLAYIRQHVPVPRTALLAGNSVHADKAFLACTPYSQVLDHLHYRILDVSSLKEAARRWGSDELLEQVPPKREVHLARDDILESIEEIRFYKEKLFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W6QBU5</accession>
    <name>W6QBU5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acyl-CoA N-acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S03g000902</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QBU5"/>
    <dbReference type="OMA" id="MDQESAM"/>
    <dbReference type="OrthoDB" id="5343688at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="79"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="3">
        <location>
            <begin position="153"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM34178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="350" mass="38892" checksum="AA0CDB6B08050532" modified="2014-04-16" version="1">MARMVTTPFPGDHSTTTKPKDAVDQKRAASPSTSQDVLNPTISPGQSTDVAIEEFEITSALKLIAVSVAQQRFLAAKSLVLHPTTLTLVAASFAYSVGVIYHHPSCWPYIVVFCTTAVLATLGIVTRLLEGYNDEAEKVGTLNWLYGHDPSSDNTTQEDPAFNSDSGITFVLVYRFGRYIVGALVMSITYNGIQPHPKANAITLPIGENYDACVRAWTVQKGFRGYGIGTALLNEAIRICYKHEWKGLRFATSHANSLRVFHSLFHSDMDQASAIWSSYLRKRVEAYRQSCAVSETRVLDASLHASESQSTLSDTRMRFICTEAEKLNRMYFHVRLGQVVDAQTRWKKIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2024-10-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>W6QBY1</accession>
    <name>W6QBY1_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S02g001810</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QBY1"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM31659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="102" mass="11216" checksum="B4580075BD461736" modified="2014-04-16" version="1">MTCFVLSLSTPGAKDSLLSTDLPLSASSCAADLSRDAQQEPIERAGGIAHGFRLQAATIHLTRIFNMFWSGIKRLWLVMGAGMTERAAYYTSVELQLKEHRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>W6QC37</accession>
    <name>W6QC37_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Structural maintenance of chromosomes protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">cut14</name>
        <name evidence="14" type="ORF">PROQFM164_S02g001870</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SMC family. SMC2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QC37"/>
    <dbReference type="STRING" id="1365484.W6QC37"/>
    <dbReference type="OMA" id="THNKIAM"/>
    <dbReference type="OrthoDB" id="10255539at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000793">
        <property type="term" value="C:condensed chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031981">
        <property type="term" value="C:nuclear lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03273">
        <property type="entry name" value="ABC_SMC2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1060.20:FF:000005">
        <property type="entry name" value="Structural maintenance of chromosomes 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000278">
        <property type="entry name" value="Structural maintenance of chromosomes 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000385">
        <property type="entry name" value="Structural maintenance of chromosomes 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1620:FF:000006">
        <property type="entry name" value="Structural maintenance of chromosomes protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1060.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024704">
        <property type="entry name" value="SMC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027120">
        <property type="entry name" value="Smc2_ABC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010935">
        <property type="entry name" value="SMC_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036277">
        <property type="entry name" value="SMC_hinge_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43977">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06470">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005719">
        <property type="entry name" value="SMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00968">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75553">
        <property type="entry name" value="Smc hinge domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="7 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0226">DNA condensation</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC hinge" evidence="13">
        <location>
            <begin position="521"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="246"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="326"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="424"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="683"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="835"/>
            <end position="984"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR005719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDM31719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="1179" mass="133049" checksum="F9EA0E8FADB9D76C" modified="2014-04-16" version="1">MRITEIVIDGFKSYAVRTVISGWDEAFNSITGLNGSGKSNILDAICFVLGITNMTTVRAQNLQDLIYKRGQAGVTKASVTIVFDNRDTAKSPIGFEEYANISVTRQIVLGGTSKYLINGHRAQQQTVQNLFQSVQLNINNPNFLIMQGRITKVLNMKSVEILSMIEEAAGTRMFEDRREKANRTMGKKELKLREIEELLKEEIEPKLEKLRSEKRAFLDFQQTQNDLERLTRLVVAHDYVRGGERLRVAGQECENKLNKAQALEDNAIKLKSEIAHLEEDVKRVRTARDKELRKGGKFQGLEDEVKNYSHELVRLTTVFDLKNASMDEEKEKRQTIQNTVTDLEKVLKEKRKIYEKLQAQYDTAKAELDAQNVEVEQKEELLQTLQTGVASKEGQESGYQGQLQDARNRASNAATEQEQGKLKINHLEKRIKEEEPRAKKAKEQNLGLLRDLEGLKSQANKLESELTRLGFEPGKEEQIYQEQTELQRDIRDLRQRADGLKRQAANIDFNYADPHPNFDRSKVKGLVAQLFTLNKDQVPAATALEICAGGRLYNVVVDSAETGTQLLQKGKLRKRVTIIPLNKISAFKASAEKIGAAQDLAPGKVDLALSLVGYDEEVLAAMNYVFGNTLICQDAETAKKVTFDPSVRMKSVTLEGDVYDPSGTLSGGSSPNSSGVLVTLQKLNEITKELRSKERQLATLEDHMKREKKKLDSVRSIKQNLDLKNHEIKLTEEQINSNSSSSIIQAVEEMRANIEQLKKDIADAKSRQAVASKDIKQIEKDMSEFSNNKDSKLEELQTTLDKLKKSFIKNSGSVKELQKELQTSRLDSEQVGSDLSAAEEQLVESDNTLSAQLEEIETQKREQARLKDAHDIAQAQLDDERAKLTGFDEELRELESAMKSKSSQITEDGLEAQKLGHQLEKLQKDQHTASQAVAHMEQEHEWIADEKEHFGRANTPYDFQNQNIAECKATLRNLTERSQGMKKKINPKVMNMIDSVEKKEGALKNMMKTVIRDKRKIEETIMNLNEYKKEALYKTWVKVNGDFGQIFNELLPGSFAKLDPPEGKDITDGLEVKVSLGKVWKQSLTELSGGQRSLIALSLIMALLQFKPAPMYILDEVDAALDLSHTQNIGRLIKTRFKGSQFIVVSLKDGMFQNANRIFRTRFSEGTSIVQALTPADLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W6QD70</accession>
    <name>W6QD70_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sec1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S03g001139</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the STXBP/unc-18/SEC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QD70"/>
    <dbReference type="STRING" id="1365484.W6QD70"/>
    <dbReference type="OMA" id="EFHIFFV"/>
    <dbReference type="OrthoDB" id="10262287at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.830.10">
        <property type="entry name" value="Syntaxin Binding Protein 1, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043154">
        <property type="entry name" value="Sec-1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043127">
        <property type="entry name" value="Sec-1-like_dom3a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001619">
        <property type="entry name" value="Sec1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027482">
        <property type="entry name" value="Sec1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036045">
        <property type="entry name" value="Sec1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043155">
        <property type="entry name" value="VPS33_dom3b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11679">
        <property type="entry name" value="VESICLE PROTEIN SORTING-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00995">
        <property type="entry name" value="Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56815">
        <property type="entry name" value="Sec1/munc18-like (SM) proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="600"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="273"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="282"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM34415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="656" mass="73121" checksum="4BEC68EFADC6D5C4" modified="2014-04-16" version="1">MAPLSGSDADYFRDKARRDLLTLLEGARGKKNLVISQELAGPVGLFVKFSVLQEYGVDRVFLLENANIDSSQRNVVFLVRGEKARHVRIVAEQIKRLQNNGNVEHEFSIFFAPRRTLMSNSVLEEAGIIGDVNIAELPLYFMPLEQDILSLELDESFEDLYLHKDPGCIFHSAKALMGVQQRHGYFPRIVGKGDNARRLADLLLRMRKELDAEDSSGLTDPSARGLLPSASVENLIIIDRDVDFGTPLLTQLTYEGLIDEYVGIKNNQADVDTSIVGPAPTPQSESSKAPQQVKQGLKRKIQLDSSDQLFSQLRDANFAIVGDILNKVARRLENEYESRHTAKTTGELREFVNRLPTYQLEHQSLRTHTNLAEEIMRLTRSETFRKTLEVQQNNAAGADSTYQHETIEELIARDVPLKTVLRLLCLESCMSGGLRPRDLESFKRQVLQAYGHQHLLTFWALEKMELLQPRSSATTMLLPTSGAQAGSKTNYGYLRKNLRLVIEEVSEKDPNDISYVYSGFAPLSVRLVQCVLQKSYMVSLIKGGTPAASNTPNTTSPGWLGFEDVVKSARGATFSIVQKGDDKAVRARQTLSGNSATKTVYVFFLGGITFTEIAALRFIAAQEAPRRKIIICTTSIISGDRMMEAAIEKGSFVKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W6QD98</accession>
    <name>W6QD98_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ATPase, P-type, transmembrane domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S02g002315</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QD98"/>
    <dbReference type="OrthoDB" id="3352408at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM32164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="54" mass="5998" checksum="F47D06ADA087C7B9" modified="2014-04-16" version="1">MELVPLYQDEPIRRDSNRSCLITENGVNDLPALKRADVGIAMRKIEAAGMVLTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W6QDN7</accession>
    <name>W6QDN7_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Succinate dehydrogenase assembly factor 3</fullName>
            <shortName evidence="8">SDH assembly factor 3</shortName>
            <shortName evidence="8">SDHAF3</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">acn9</name>
        <name evidence="9" type="ORF">PROQFM164_S03g001329</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 8">Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Promotes maturation of the iron-sulfur protein subunit of the SDH catalytic dimer, protecting it from the deleterious effects of oxidants. May act together with SDHAF1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 8">Interacts with the iron-sulfur protein subunit within the SDH catalytic dimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the complex I LYR family. SDHAF3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QDN7"/>
    <dbReference type="STRING" id="1365484.W6QDN7"/>
    <dbReference type="OMA" id="WQQTNEN"/>
    <dbReference type="OrthoDB" id="278329at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034553">
        <property type="term" value="P:mitochondrial respiratory chain complex II assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006105">
        <property type="term" value="P:succinate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20270">
        <property type="entry name" value="Complex1_LYR_SDHAF3_LYRM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008381">
        <property type="entry name" value="SDHAF3/Sdh7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13137">
        <property type="entry name" value="DC11 ACN9 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13137:SF6">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE ASSEMBLY FACTOR 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13233">
        <property type="entry name" value="Complex1_LYR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6 8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU368039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM34605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="130" mass="14819" checksum="8CDC5052C3ACBBDB" modified="2014-04-16" version="1">MRIAQRLFMAMPASIGSKSSLSEALALLPPLQLYRRILRVHRKLDPEMRVLGDSYVKNEFRAHRSVENPLHIIGFLTEWQLYAQKLEGDSWAGDKLDKAKLDKMSDQQLGQLLELMQALRNEGEGEGEGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W6QE89</accession>
    <name>W6QE89_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Vacuolar amino acid transporter 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">AVT2</name>
        <name evidence="11" type="ORF">PROQFM164_S01g001713</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QE89"/>
    <dbReference type="STRING" id="1365484.W6QE89"/>
    <dbReference type="OMA" id="FLFFGSQ"/>
    <dbReference type="OrthoDB" id="28208at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF458">
        <property type="entry name" value="SODIUM-COUPLED NEUTRAL AMINO ACID TRANSPORTER 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="192"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="236"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="281"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="314"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="354"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="390"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="433"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="473"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="496"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="529"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="10">
        <location>
            <begin position="161"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="8"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="47"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDM27902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="566" mass="61768" checksum="77A688CA4A3BB657" modified="2014-04-16" version="1">MPGDELSEDHLYARNGRDEHEAQSLLSASSEEHDLALHPEPLPSPIPSHNATSSISHSAISQPATDGKRRTPRTMNRVRFDLDEEPENNRISIERTLSPDDSPDDTLWLEDEDYELGNRGPGTHHSGQSIPLLTNIEAPSVTLATSDDFFPEDHLENARPRSGMKMAFMNMANSIIGAGIIGQPYALRQAGMAMGIVLLTALTVTVDWTIRLIVVNSKLSGADSFQATMQHCFGKSGLIAISVAQWAFAFGGMVAFCIIVGDTIPHVLGALFPSLKDMAFLWLFTDRRAVIVIFVLVVSYPLSLYRDIAKLAKASALAFVSMIVIVVTVITQGFRVPPESRGEIKSHLVFNTGFFQAVGVISFAFVCHHNSLLIYGSLKKPTLDRFARVTHYSTGISLVMCLAMGIAGFLSFGSKTQGNVLNNFPSDNIVVNIARFCFGLNMLTTLPLEAFVCRSVMTTYYFPDEPHNTVRHIIFTTALVVTSMVLSLITCDLGSVFELIGATSAAALAYIFPPLCYIKLSSATRREKIPAYLCICFGVLVMGVSVVQAVIKIIRNDGEAHSCSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W6QEI7</accession>
    <name>W6QEI7_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DUF2241 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S04g000029</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QEI7"/>
    <dbReference type="STRING" id="1365484.W6QEI7"/>
    <dbReference type="OMA" id="AFYHDHI"/>
    <dbReference type="OrthoDB" id="10064407at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046394">
        <property type="term" value="P:carboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2130.10">
        <property type="entry name" value="VC0802-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027795">
        <property type="entry name" value="CASTOR_ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018717">
        <property type="entry name" value="DUF2241"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39199">
        <property type="entry name" value="BLR5128 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39199:SF1">
        <property type="entry name" value="BLR5128 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10000">
        <property type="entry name" value="ACT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13840">
        <property type="entry name" value="ACT_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2241" evidence="1">
        <location>
            <begin position="4"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="CASTOR ACT" evidence="2">
        <location>
            <begin position="78"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM35148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="140" mass="15202" checksum="36EE337894C27FB0" modified="2014-04-16" version="1">MAPPGEKNISILLATMQPSLDPAIYVFLTTKSPLHSLPLSTLQPQLIVQEEEGTTIVTTEALATSHDFNEPIFPCKKISLTIHSSLEAVGLIAAITNRLKDHGISTNVVSGYFHDHIYVPVARAEDAMRVLEEEAAEARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2024-10-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>W6QEJ9</accession>
    <name>W6QEJ9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S02g002780</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QEJ9"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM32629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="50" mass="5545" checksum="892C65F434071C6E" modified="2014-04-16" version="1">MCRAGILFGQLERPGALGPVTSMLTMAVVVWRSWPCPLKMDSSFDSLTTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W6QF10</accession>
    <name>W6QF10_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Translation initiation factor eIF2B subunit gamma</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">eIF2B GDP-GTP exchange factor subunit gamma</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PROQFM164_S04g000209</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM164</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">Component of the translation initiation factor 2B (eIF2B) complex which is a heterodecamer of two sets of five different subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta and delta comprise a regulatory subcomplex and subunits epsilon and gamma comprise a catalytic subcomplex. Within the complex, the hexameric regulatory complex resides at the center, with the two heterodimeric catalytic subcomplexes bound on opposite sides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eIF-2B gamma/epsilon subunits family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QF10"/>
    <dbReference type="STRING" id="1365484.W6QF10"/>
    <dbReference type="OMA" id="YPKCLIQ"/>
    <dbReference type="OrthoDB" id="10250549at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005851">
        <property type="term" value="C:eukaryotic translation initiation factor 2B complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002183">
        <property type="term" value="P:cytoplasmic translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051960">
        <property type="entry name" value="eIF2B_gamma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056729">
        <property type="entry name" value="GMPPB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45989">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45989:SF1">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25087">
        <property type="entry name" value="GMPPB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mannose-1-phosphate guanyltransferase C-terminal" evidence="10">
        <location>
            <begin position="441"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="153"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF25087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDM35328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="538" mass="59493" checksum="673B810209F137C3" modified="2014-04-16" version="1">MPHAGPMDFQALILCGPGGSLNTFTSRPEEYPKCLIQVANRPMLFYAIDFCRRSGVTDITLITPPLSVPPLRAALDQNPYLTSFYSPSVSLIAPKDLEMTMGTAELLRLPEVQRCITTNFLLLPCDLICEIPGESILEAWISSPYALNDGSDSRGTQHASPPTNSYFDRQREARPGGLAVYYQTDHREESIQAEGTDFIAIAPLQQNEEPVVHGPDGPLIPRFSLSKLLMSMPMDTIKEKMKEDQGLLLRHSLVQNCPRIRILTTFRDAHVYVFPYWVKDLVHHQSKLKSVREDLVGAWAKSTWQKGLGAKLGLTKNFNEDTTFTQETEFTPESSYTGAFVDKVIDIKDMSTTRTRSSCELQPEQLHQSIELPQILAYVHRGSTPFIRRVDNIGVLLSTSLFLAKLPSIEEVGRKAASPLAHAHKVAYPEGVASPSNVTKKDCLLGENVIVASGAVIKESVIGANCQIASAARIIRCVLMEGVVVEARAQLTRCVIGRRAQIGRGSVLKGCEVQDANVIPEETNARDEKFMVSENLFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W6QFA5</accession>
    <name>W6QFA5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glucose-repressible protein Grg1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S04g000344</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QFA5"/>
    <dbReference type="OMA" id="INESGHD"/>
    <dbReference type="OrthoDB" id="10039103at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020100">
        <property type="entry name" value="Glc-repressible_Grg1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38789:SF1">
        <property type="entry name" value="GLUCOSE-REPRESSIBLE GENE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38789">
        <property type="entry name" value="REPRESSIBLE PROTEIN GRG1, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G14210)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11034">
        <property type="entry name" value="Grg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM35463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="71" mass="7391" checksum="B49F2144FEADEAFC" modified="2014-04-16" version="1">METAKNAVNYVAETVQGGGAEASKETNKHVAKDSDASLGSRATAAKDAVVDKKDEASHNTKADVHKEAAKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W6QFU2</accession>
    <name>W6QFU2_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Anhydro-N-acetylmuramic acid kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S04g000131</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QFU2"/>
    <dbReference type="STRING" id="1365484.W6QFU2"/>
    <dbReference type="OMA" id="TGPGNMV"/>
    <dbReference type="OrthoDB" id="5427593at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006040">
        <property type="term" value="P:amino sugar metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009254">
        <property type="term" value="P:peptidoglycan turnover"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd24051">
        <property type="entry name" value="ASKHA_NBD_LGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005338">
        <property type="entry name" value="Anhydro_N_Ac-Mur_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30605">
        <property type="entry name" value="ANHYDRO-N-ACETYLMURAMIC ACID KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30605:SF0">
        <property type="entry name" value="ANHYDRO-N-ACETYLMURAMIC ACID KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03702">
        <property type="entry name" value="AnmK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM35250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="446" mass="48752" checksum="9D60522BF0EAA936" modified="2014-04-16" version="1">MVINSVNGTSSHSLDITVLGLNSGTSMDGIDCALCRFCQETPESPMHFELLKASTTAYYGEIPLEPVIKKRVMNMILHNKTSPSELSEVNVILGETFASAVHQFCKDYNVDIKSIDVLGSHGQTIWLLSMPEAGETRSALTMAEGTFLASRTGITSVTDFRVSDQAAGRQGAPLIAFFDALVLHHPTKLRACQNIGGIANVCFVLPDSHGGVDACYDFDTGPGNVFIDAVVRHYTNGEREYDQDGEMGARGAVDQGLVDDFLTHPYFALEPPKTTGREVFRDTLAYEFIAKAEAKGLKPDDVVATITRVTAQAIVDHYRRYAPKGLEIAEIFMCGGGAYNPNIAAFIQENYPNTRIMMLDEAGIPGGAKEAITFAWQGMEAVVGRSIPVPTRVETRQEYVLGKVSPGKNYRKVLRQGMLFGAGRDHLPPVKELINYIDGKAFDNKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W6QFX2</accession>
    <name>W6QFX2_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major facilitator superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PROQFM164_S04g000171</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QFX2"/>
    <dbReference type="OMA" id="HKLHNNL"/>
    <dbReference type="OrthoDB" id="3437016at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015174">
        <property type="term" value="F:basic amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF191">
        <property type="entry name" value="VACUOLAR BASIC AMINO ACID TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="41"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="78"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="166"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="234"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="263"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="302"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="337"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="370"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="396"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="434"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="505"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="44"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="21"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM35290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="536" mass="57412" checksum="F50343C5F7AC9ECF" modified="2014-04-16" version="1">MSAGDTAREPASEQTPLLRDSPNSDANENTPLHQEPSTKELIWILGSIWLGVFLAALDTTIVATLSAPISSSFNSFSLLSWLATSYLISNAACQPLSGRLTDIYSRRWGLVFSNVFFALGNLICGLARAQWVIIFGRVVAGVGGGGLTAISTFVTSDLVPLRKRGIWQGIGNICYGAGMGLGGVFGGWINDTLGWRWAFLLQVPFLIISCILVAVKVKIPVKESDTARIKRVDFLGAITLVLTLVTLLLGLNTGGNQVPWTHPLVLTSLVASAVFLGLFIYVEAVVASEPVIPVRLLLNRTVAAACLTNWFGTMAIFGLLFYLPVYFQVQGLSPTAAGARLIPQAVGTSIGSLGSGIIMRASGRYASLNYVAMAVQVLSAGLICTLNLHTPVGLPFLYFFLGGASYGSMLTITLVALISAVDHQHHAVVTSASYAFRSTGSTIGITVASAVFQNTLRLGLWSRLGERKDAKELIERLRDSLDEIWKLPADLTSGVLDAYMDSLRAVFVTLLGLAVLGALTSLAMREHKLHNNLARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W6QFX4</accession>
    <name>W6QFX4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="10">S1/P1 nuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PROQFM164_S04g000604</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the nuclease type I family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QFX4"/>
    <dbReference type="STRING" id="1365484.W6QFX4"/>
    <dbReference type="OMA" id="GYRLANW"/>
    <dbReference type="OrthoDB" id="441446at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006308">
        <property type="term" value="P:DNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11010">
        <property type="entry name" value="S1-P1_nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.575.10">
        <property type="entry name" value="P1 Nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008947">
        <property type="entry name" value="PLipase_C/P1_nuclease_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003154">
        <property type="entry name" value="S1/P1nuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33146">
        <property type="entry name" value="ENDONUCLEASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33146:SF26">
        <property type="entry name" value="ENDONUCLEASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02265">
        <property type="entry name" value="S1-P1_nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48537">
        <property type="entry name" value="Phospholipase C/P1 nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004881571" evidence="9">
        <location>
            <begin position="21"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="292"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="302"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDM35723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="341" mass="37185" checksum="BF87E403FE3685A4" modified="2014-04-16" version="1">MVSLFRIAFVTFGVIHGANAWGVLGHATVAYVAQHYISSEAASWAQEILNDTSSSYLANIASWADQYRLKDDGKWSAPLHYIDAMDDPPTSCNVDYERDCGAEGCSISAIANYTQRAGDSKLTTANTAEALRFLVHFLGDLTQPLHDENYEVGGNGISVTFNNYSDNLHSDWDTYMPVQLIGGSSLADAQGWADSLVDEITSGTYKKQAASWIKGDTISDTITTATRWASDANSFVCTVVMPDGAAALQTGDLYPTYYNSAIGTIELQIAKGGYRLANWLNMIYKQNVTAKNTPGKFGKGHRQPEFVREPHHEPNKMSRANLARAAMGGSCCKSEGREHSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W6QFZ6</accession>
    <name>W6QFZ6_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Cation efflux protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PROQFM164_S02g003266</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM33114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QFZ6"/>
    <dbReference type="STRING" id="1365484.W6QFZ6"/>
    <dbReference type="OMA" id="CLFHQHG"/>
    <dbReference type="OrthoDB" id="9944568at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1510.10:FF:000021">
        <property type="entry name" value="Solute carrier family 30 (Zinc transporter), member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1510.10:FF:000026">
        <property type="entry name" value="Zinc/cadmium resistance protein-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027470">
        <property type="entry name" value="Cation_efflux_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45820">
        <property type="entry name" value="FI23527P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45820:SF4">
        <property type="entry name" value="ZINC TRANSPORTER 63C, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16916">
        <property type="entry name" value="ZT_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="Cation efflux protein cytoplasmic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="9"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="327"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="362"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="10">
        <location>
            <begin position="10"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="10">
        <location>
            <begin position="314"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein cytoplasmic" evidence="11">
        <location>
            <begin position="391"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="138"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="191"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="247"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="467"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="191"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="303"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="486"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDM33114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="524" mass="57639" checksum="592C411000634D55" modified="2014-04-16" version="1">MGLSKTNRILILLVIDTAFFLLELITGYAVHSLALVADSFHMLNDVLSLCVGLWAVKVANRETSSNTYTYGWQRAETLGALVNGVFLVALCMSIFLEATQRLFEPQEVQNPRFVCIVGCFGLASNIVGLALFHDHSHGPGGHDHGNGGEHDEHDHDHDIEAGDHDHDHTPIAEHSESLAAPKVLDRAASLPQNALTQSPTDPSRKRRDLQTRGPRSYSTSTGRGFVSADDIPVLPERLRQGIIAASQYRNEQSSDSDNGNDEDEQPSERSGLLSHRDRTTNYTDEEGAPTKIHHHPDEDVHKSHNHAQPKPKGQKKGHNHDLNMRGVFLHVMGDALGNIGVIVSALIIWLTDYKWRFYADPVISLIITVIILASAIPLCKAASRILLQAVPPGMSIDHIKEDIERLPGVIGSHHLHVWQLSDTKVVASIHLQVDTEIKGEGSERYMRLARQVRRCLHAYGIHSSTIQPEFAPESDVEDNGQGSSSHTEDHIPSRAASVREGDPQACLLECDNNCAEGGQCCPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W6QG98</accession>
    <name>W6QG98_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="4">2,2-dialkylglycine decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">dgdA</name>
        <name evidence="4" type="ORF">PROQFM164_S04g000709</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QG98"/>
    <dbReference type="STRING" id="1365484.W6QG98"/>
    <dbReference type="OMA" id="GQMSCLL"/>
    <dbReference type="OrthoDB" id="10261433at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049704">
        <property type="entry name" value="Aminotrans_3_PPA_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45688">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45688:SF13">
        <property type="entry name" value="ALANINE--GLYOXYLATE AMINOTRANSFERASE 2-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM35828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="463" mass="50251" checksum="3FFECD451DF077C8" modified="2014-04-16" version="1">MAPGITTEESTVTIRPAKTDNPILYNDVNQQELQAKAAKYLLNYGTKFNKDVICGSRGLYVYTASGQKVLDFTSGQMSCLLGHGHPEIVQTITDHAASLDHLFSGMISPPVISLGERLCDLLPPGLDKAFFLSTGGESNEAAIKMAKVYTGKFEIVGLGGSWHGVTAQALGTQYHFGRRGQGPLMPGMLMLPPPNAYRSIFRNADGSYDWQAEMEYGWRMIDMQSCGSLAACIVECIQSSAGMHVLPPGYLKALKRECEKRGMLLIVDEAQTGIGRCGDLVAINHEEVVPDILTLSKTLGNGLPLSAVVTSAEIERVCVERDFCFYTTHVNDPLPTAVGDKVLEIVVRDRLVEHSRAMGKVLHERLNVLKDKYGCIGDVRGRGLMAGVEIVEDRQTKNPALALGKAIGDRAYELGLWANLSSHPSFGGAFRIAPPITITEDQLLRGLEILEEAFATTPGTMPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>W6QGJ5</accession>
    <name>W6QGJ5_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">26S proteasome regulatory subunit 6A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">RPT5</name>
        <name evidence="14" type="ORF">PROQFM164_S03g001823</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM35096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QGJ5"/>
    <dbReference type="STRING" id="1365484.W6QGJ5"/>
    <dbReference type="OMA" id="NKISHEH"/>
    <dbReference type="OrthoDB" id="9443236at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000009">
        <property type="entry name" value="26S protease regulatory subunit 6A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000076">
        <property type="entry name" value="26S protease regulatory subunit 6A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000037">
        <property type="entry name" value="26S protease regulatory subunit 6A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-0647">Proteasome</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="13">
        <location>
            <begin position="241"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00069320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDM35096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="462" mass="51554" checksum="CB6FC755EAF78FA9" modified="2014-04-16" version="1">MSTLEDLEDLEQEQREKKQDQNDGDGKKPEGDGDADMTDADKKDEEEEMLDEDILNSSTADIVTRRRMLENEMRIMKSEFQRLTHEQSTMREKVKDNQEKIENNRQLPYLVGNVVELLDLDVEAEAAEEGANIDLDATRVGKSAVIKTSTRQTIFLPLIGLVDHETLKPGDLIGVNKDSYLILDTLPAEYDNRVKAMEVDEKPTEKYTDIGGLDKQIEEIVEAIVWPMKEAERFKKIGIKAPKGALMYGPPGTGKTLLARACAAETNATFLKLAGPQLVQMFIGDGAKLVRDCFALAKEKAPSIIFIDELDAIGTKRFDSEKSGDREVQRTMLELLNQLDGFASDDRIKVLAATNRVDVLDPALLRSGRLDRKIEFPLPNEEARANILQIHSRKMSVEDSVNWAELARSTDEFGGAQLKAVCVEAGMIALRKGLSKIGHENYVDAIAEVQAKKKDTNMGIYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>W6QH47</accession>
    <name>W6QH47_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein-serine/threonine phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PROQFM164_S03g000248</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM164</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the PP2C family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="3"/>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QH47"/>
    <dbReference type="STRING" id="1365484.W6QH47"/>
    <dbReference type="OMA" id="HVMKLSM"/>
    <dbReference type="OrthoDB" id="659at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000222">
        <property type="entry name" value="PP2C_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832:SF803">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01032">
        <property type="entry name" value="PPM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="11">
        <location>
            <begin position="27"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="173"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="233"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="173"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="234"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDM33524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="327" mass="35898" checksum="E827CDAB0784909E" modified="2014-04-16" version="1">MVVAHKALRDQIFRKSISTSDTVTLLDAGAGQSQGGRKHQEDRSTVIFPNHFPSEVKDEVAFFAIYDGHGSGLVSDHVNGCLHHLIGQHPEFERGNWPAAIKAALAEEDSIMLDRFKHESAEPAISGSTVALCCINLTKGELVVSNLGDSHVILAERDRKTEHPYHIRRLTEAHKPSDPSEKTRIEKAGGQVNDRSGTERIGSLNMSRALGDLQYKNPVNNTFTDNSVLDPAASASSRTESRGNFLSNDPYISRRTLNPDRRYLLLVVSDGVTDRLDDTSLVQHVMKLSMRGKRANEIAQEIATNSANKPHSDNATCIVAMLDGRVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W6QHL2</accession>
    <name>W6QHL2_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S05g000106</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QHL2"/>
    <dbReference type="STRING" id="1365484.W6QHL2"/>
    <dbReference type="OrthoDB" id="5428321at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM36273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="103" mass="12006" checksum="96260C7ED9B5D36C" modified="2014-04-16" version="1">MNKFNFWVIKSGLFGDQLAGRDSLSIYRLDLKVDPSEVRLKTEDECLYIWQIDDLSLEPLFQKYMSKYSVGAYIQLHCEVGQTFYTVPAKREKQTDLENVACI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>W6QHU2</accession>
    <name>W6QHU2_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Armadillo-type fold</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PROQFM164_S04g000457</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">RNA-binding nucleolar protein required for pre-rRNA processing. Involved in production of 18S rRNA and assembly of small ribosomal subunit.</text>
    </comment>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QHU2"/>
    <dbReference type="STRING" id="1365484.W6QHU2"/>
    <dbReference type="OMA" id="WAVDYSM"/>
    <dbReference type="OrthoDB" id="668540at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
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    </dbReference>
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        <property type="term" value="P:post-transcriptional regulation of gene expression"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ARM-like"/>
    </dbReference>
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        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033133">
        <property type="entry name" value="PUM-HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033712">
        <property type="entry name" value="Pumilio_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537:SF48">
        <property type="entry name" value="MEIOTIC COILED-COIL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537">
        <property type="entry name" value="RNA BINDING PROTEIN PUMILIO-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00806">
        <property type="entry name" value="PUF"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50302">
        <property type="entry name" value="PUM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50303">
        <property type="entry name" value="PUM_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="PUM-HD" evidence="7">
        <location>
            <begin position="416"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="5">
        <location>
            <begin position="482"/>
            <end position="517"/>
        </location>
    </feature>
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        <location>
            <begin position="518"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="5">
        <location>
            <begin position="710"/>
            <end position="745"/>
        </location>
    </feature>
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        <location>
            <begin position="30"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="100"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="257"/>
            <end position="308"/>
        </location>
    </feature>
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        <location>
            <begin position="348"/>
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        </location>
    </feature>
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        <location>
            <begin position="797"/>
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        </location>
    </feature>
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        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
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        <location>
            <begin position="67"/>
            <end position="83"/>
        </location>
    </feature>
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        <location>
            <begin position="262"/>
            <end position="271"/>
        </location>
    </feature>
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        <location>
            <begin position="292"/>
            <end position="303"/>
        </location>
    </feature>
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        <location>
            <begin position="348"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50303"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CDM35576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="819" mass="90483" checksum="9DB2BBDDD20BC018" modified="2014-04-16" version="1">MSTLSGPSTLGRMGNGGCFTSNDTIDVRNLSFGHDSSNPQNSIAHYGSSDTAETSRHGMLQSLSGEGAEHSSSKKQKLDHIKVEPLNGQTSDLDRILAKISPKTQPLSRSETDRSSVSSQITPVTTVSTLTLKKAPNPYPQEDRTVELLRLRQELLAANSKIALQEQELAQTRVIKHTLDQALGPSSEADFGSREITEQTISHLQNAFNASSSAFSHCQDAWSAQDDSQSDVSDPLSTGAYNRSRALWAQNEAATDREYGESLSGTSSSTSQEPNRFWGVSNVYPPFPGPPSLQSQRPHSGSPASPCGFYSRPIGEQMLCPSGPITGARRSITQNSRGGSLFPIQSTPWGEFASGSSSEQTVKSPASPKRPPSAFQQIGLYSVPSYPPRPIGSPLSPTATEFTGTNTNETTWTNSTSGNSIQTYVSPLEPLNYRRLLDKNVSCDWKYIVDKIICNNDQQASIFLQQKLKVGTTEQKYDIIESIVHQAYPLMVNRFGNFLIQRCFEHGTPEQVVAIANAIRGNTLNLSMDAFGCHVVQKAFDCVSEEHKAIMVHELLRRIPETVVHRYACHVWQKLFELRWSGEPPQVMAKVNDALRGMWHEVALGETGSLVVQNIFENCVEEEKRPAIEEVLAKIDVLAHGQFGNWCIQHICEHGAPHDKSRAVEHVLRWSVDYSMDQFASKIVEKCLKIGGTEFMDHYLSRVCTGRSDRPRMPLIDIAGDQYGNYLIQWILMNAAPHQRELVASHIRKHMVSLRGSKFGSRVAMLCCNPSHATRPGPGAGMQIGRFNNFNEDKFTTTSQSGGRFGRGHQWGPHYAPLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W6QHU7</accession>
    <name>W6QHU7_PENRF</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S05g000206</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM36373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="79" mass="8434" checksum="38F21096B54F9A7B" modified="2014-04-16" version="1">MDIAGLLNNSSDSCRHPGADLLHRNGETPFHNPGNLVAGPRYLFSKGSSSPLSCRGLKASFLRATLEGVRSARIIENNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W6QJ19</accession>
    <name>W6QJ19_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pre-mRNA-splicing factor cwc26</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cwc26</name>
        <name evidence="3" type="ORF">PROQFM164_S03g000938</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CWC26 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1365484.W6QJ19"/>
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    <dbReference type="OrthoDB" id="6022at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070274">
        <property type="term" value="C:RES complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018609">
        <property type="entry name" value="Bud13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051112">
        <property type="entry name" value="CWC26_splicing_factor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31809">
        <property type="entry name" value="BUD13 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31809:SF0">
        <property type="entry name" value="BUD13 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09736">
        <property type="entry name" value="Bud13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="13"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="198"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="117"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="198"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="223"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM34214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="335" mass="37906" checksum="88754525906AF805" modified="2014-04-16" version="1">MPGSLADYLAKNYLTADPTTERPKKKRKKTKAIDTAGSGLIIADDDPPDIRSLGNTEEDDEDRPYFDTSARTTEFRRAKKSSWKTIGGPTSGQGSEQEAADAILADAAAERAAHQDPDDEDALMIENEDDGAGRMESGVRGGLQTAAQTAAMVKAQEKRRKAEEAQYRDPSAVNQKSQETIYRDASGRIINVAMKRAEARRAEEEKREKEEQAREALMGDVQRQQREERRQNLQDIKAMPLARTIEDEELNEDMRARDRWNDPAAEFLTARRDAGASVTGRPLYQGSFQPNRYGIRPGHRWDGVDRGNGFEKDWFTSRNKKSRFEALEYQWQMDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>W6QJS5</accession>
    <name>W6QJS5_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">chitin synthase</fullName>
            <ecNumber evidence="2">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PROQFM164_S03g001198</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-D-glucosamine = [(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16637"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9595"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="EC" id="2.4.1.16"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:16638"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="2"/>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1365484.W6QJS5"/>
    <dbReference type="OMA" id="RLAEWAN"/>
    <dbReference type="OrthoDB" id="370884at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003774">
        <property type="term" value="F:cytoskeletal motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.820:FF:000010">
        <property type="entry name" value="Chitin synthase 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014876">
        <property type="entry name" value="DEK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF13">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03142">
        <property type="entry name" value="Chitin_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08766">
        <property type="entry name" value="DEK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109715">
        <property type="entry name" value="DEK C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51998">
        <property type="entry name" value="DEK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="720"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="756"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1017"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1408"/>
            <end position="1431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1443"/>
            <end position="1462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1469"/>
            <end position="1492"/>
        </location>
    </feature>
    <feature type="domain" description="DEK-C" evidence="13">
        <location>
            <begin position="1704"/>
            <end position="1760"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDM34474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="1762" mass="196237" checksum="B436F5590244462E" modified="2014-04-16" version="1">MSNRYSVFSTQSTGLSVGPRPQHGAQVSTTTLLNALHSFYTAGQPYQLDSATSLVVNTWVTAATTLPDGRTGATVDRDLAIRAWEHARRRAEDGSVVLGALHQSTPSLLEPFIAAIPVETPEVALIALSAIRPFLTAVTSFNPSYSLHSALAATFNLSLQGSVVGLSFALSTSGINVRKGLLDIQPETGYRAFDAFYYLLTSTSTAAEREFLDLKDPAEYTLLNRSNTYNPPHYLPTADDAAAAEDFRASLKSIGIKGAAQRGLLSALAGLLKLGNAVGFEVDQEDLEEVCEDAGGLLGIDPEILLHKCSTDEREVLIAGLYEALVDWVISKANEAIAADIQIALENDSSNGGGAAQWSTDDTVNLTVIDIPRPALGKAIMMRGIFDDALGLNAEMKDDGIPLPPIGASIISEMNSAVAQVEPDLNIMTGLAGREREHDLDKRQGVLEKVGVELEIDAFLRRVLFPNDTEGISVGKRGRFDLANTLNSSRVWYHLSIHPTDDMPEQLVSLGPTAWSAGAVSRQLRDWRLPEWANRRLKQLDFTADFDVEEFVSRYARLGCTEGQDGVENWIIERGWSNGDAVVGEQRVWMREGAWWEAESMLDLKPEETQVNPFMYGPALYETAFTPDGTPIHENSNLLSMPPSGAIAPSVIDGAKSIAPSAPFANAVNTGDYGLGRKGDDKKGDIAYYDEYGRYVGEFDPEFGDPKHIEKKTITLGRRLWTGFVWALTFWIPSFVLRYIGRMKRPDVRLAWREKLVLVFLILLFNAIVCFYIIAFGDLLCPNKDKVWNKKEVSWHTTDNNFYVGIHGRVYDISKFWRTQHSDITGETTSSTNMEQFGGEILDAYFPPPLNRYCSSFVTSDTLALQHNDTSAIALSTAEHKSGAQATSTTSALHKSTWYEKKFLPKIGTYYKGDLVWTRDTIKKQADADSRYWVIKDQKVYDLTDYFYTLSTMNNLDTYDWLPSTLTALFKDNMGEDVTDKWEDTTDFKNAQTCLDFVFYVGKVDFRESARCTVNNWILLTFTILICAVILVKFLAALQLGSKRRPTPQDKFVICMVPAYTEGENDLRKGLDSLTALQYDNKRKLIFVICDGMIVGGGNDRPTPKIVLDILGVDPKMDPPALPCKSLGQGSEQLNYGKVYSGLYEYEGNVVPYIVVVKVGKESEQRKSKPGNRGKRDTQVLLMQFLNRVHHRSPMSPLELEMFHQINNVIGVDPELYEYCLMVDADTTVKEDSLNRLVAACAADAKIAGICGETSLQNEERSWWTMIQVYEYYISHHLAKAFESLFGSVTCLPGCFTMYRLRTADKGRPLIISDKVIHDYADNDVDTLHKKNLLSLGEDRYLTTIMTKHFPAMSYKFIPDAYASTAAPDTWSVLMSQRRRWINSTIHNLVELAALEDLCGFCCFSMRFVVLVDLVGTLILPATCVYLTYLIYRVASNTGPFPMISIIMLAGVYGLQAIIFIVKRQWQHIGWMIIYLLAYPIYNFVLPLYAFWKQDDFTWGTTRIVIGEKGDKRVIAVEDEPFDPRSIPLQRWDDYAMANNLPGRRGEVSASQEKVYATGRYDEMAMEMDDMHSQYSSVKPASTILTGFPGQGRNHPYMPPQSPAPFVGGNVPGNRNSHMSNFSRYTDLPQMSPRMGGHSAQASRHMSMGGLSAYQDNPMASSRHSVGMMQSSENLLGNAGSRSPLPQYPSRPASTAFDFRSASGPDEGAITEAIRGCLAEVDLDTVTKKQVRVLVEHRLQTSLTGDKRAFLDRQIDQELANM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W6QJV2</accession>
    <name>W6QJV2_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">GPI mannosyltransferase 2</fullName>
            <ecNumber evidence="12">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">gpi18</name>
        <name evidence="13" type="ORF">PROQFM164_S05g000533</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Endoplasmic reticulum membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the PIGV family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="12"/>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QJV2"/>
    <dbReference type="STRING" id="1365484.W6QJV2"/>
    <dbReference type="OMA" id="CEWTLPS"/>
    <dbReference type="OrthoDB" id="10252502at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031501">
        <property type="term" value="C:mannosyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000009">
        <property type="term" value="F:alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004376">
        <property type="term" value="F:GPI mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007315">
        <property type="entry name" value="PIG-V/Gpi18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12468">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12468:SF2">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04188">
        <property type="entry name" value="Mannosyl_trans2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 12 13" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5 12" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="128"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="220"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="266"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="335"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="367"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="423"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDM36700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="448" mass="48734" checksum="DB0BCCB316541B43" modified="2014-04-16" version="1">MAPVQPTARPPPLFATLLRLDNPIRSLTLAFWAWKVLLYIVVVACPGSGYDTSTSLISYAANPTAQSESLSGPLKFARWDSIYFLDIAEKGYLYEQEWAFGWGYTKLLSIFVAGIRLSGGDAGPASTAMVGVVLSHVAHYLSVLALYRLSANIFGHATATQHLICFLSAALHIISPAGAFLSAPYGESIVSFLNITGFYLYSSSLIAERNGATRLRDIRVLTSAVLFAVGTMVRSNGVLSGFLFAYDAAVLGWKILTKGPTLHTTVRLAVVIVGGCIVGSGIVIPQILAYRMYCMSEGDLRPWCEWTLPSIYGWVQNHYWNVGFLRYWTVSNIPLFLLAAPMLAILCRSTLWALQSPSSSSTSPGSMLARLAVPQGLLAVMAFTSYHVQIINRISSGYPLWYWYLVTSAVDLSSSTPKQSRTLVAAVYSMVAYALIQGVLFGSFLPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W6QK77</accession>
    <name>W6QK77_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Rab-GTPase-TBC domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S05g000234</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QK77"/>
    <dbReference type="STRING" id="1365484.W6QK77"/>
    <dbReference type="OMA" id="MYPTARK"/>
    <dbReference type="OrthoDB" id="26371at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.750:FF:000007">
        <property type="entry name" value="TBC1 domain family member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000037">
        <property type="entry name" value="TBC1 domain family member 22A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000001">
        <property type="entry name" value="TBC1 domain family member 22B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.750">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957:SF26">
        <property type="entry name" value="LD44506P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="2">
        <location>
            <begin position="266"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="70"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM36401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="588" mass="66212" checksum="E20DD5DBB44D8E26" modified="2014-04-16" version="1">MASKKGQQEMVQVDNSERAASPFWAGRSTPLNQGSSKLYGSNTVVGASYSHANIVQPTSSHSAPRTPPKTSATNAASNSARKSGNMVTSPPRQLYPGIMADGVDEWSRDPTEEDEEEDEEDEIVYDDDEDEFGLPSLASMRRKRSAPLKAQNIDFSGGNPSTLGYGLAAANRHRADSSDIAEERGAPMYPTARKGEGKILRPQYKDILHDPANALNLINHSPPPIDASPKERDIHSSRITRINKFKRILQASTVSPTELRDLAWSGVPEEVRPMTWQLLLGYLPTNSERRISTLERKRKEYLDGIRQAFDRGSGASSANPSSSKGRGRGLDEAVWHQISIDVPRTSPHIPLYGYEATQRSLERILYLWAIRHPASGYVQGINDLVTPFWQVFLGVYITDLNVEEGMDPGQLPRSVLDAVEADTFWCLTKLLDGIQDNYIYAQPGIHRQVRALRDLTVRIDAALAKHLEQEGVEFMQFSFRWMNCLLMREMSIKNTIRMWDTYMAEEQGFSRFHLYVCAAFLVKWTDQLVKMDFQEVMMFLQALPTKGWTEKDIELLLSEAFIWQSLFQDSRAHLRPAGDEPPDNGISY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W6QKB7</accession>
    <name>W6QKB7_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Rhodanese-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S05g000274</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QKB7"/>
    <dbReference type="STRING" id="1365484.W6QKB7"/>
    <dbReference type="OMA" id="YKRPYEG"/>
    <dbReference type="OrthoDB" id="566238at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004792">
        <property type="term" value="F:thiosulfate-cyanide sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44086">
        <property type="entry name" value="THIOSULFATE SULFURTRANSFERASE RDL2, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44086:SF10">
        <property type="entry name" value="THIOSULFATE SULFURTRANSFERASE_RHODANESE-LIKE DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="16"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="138"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="275"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM36441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="528" mass="57950" checksum="4D7FFC10F3AC223C" modified="2014-04-16" version="1">MAKSITARELRQHWVNHHEVALLDVREEGPYSESHPLFALSVPVSEIEKKLPPLVPRLSAPIVVYDDGEGYAARATVRILALGYRDVAILQGGLSGYALVGEVYRDVNVPSKAFGELVESINHTPSLSARDIKDVLESETDVVVLDARRFEEYKTMSIPRGRSCPGGELLYRFFEAVPSPETTVVVNCAGRTRSIVGTQSLVNSGIPNKVVALRNGTIGWTLEGLELETKQTERVPGPSVEALQKAREYAESWANHVGVSIINGDQLTRFSTESENRSLYLLDVRDPEEYALGHPTGFSNAPGGQLVQATDEWVGVRGARIVLYDTDGVRGRMTASWLLQLGWEVYVFEERLAVPDRLVLPEVSSWNPPKDGAITVNDLQNLEGATVVDLARSPSYRKGHIPGAWFASGPELARDLRAIDGDGPIVLTSPDGDVAATNVDDARNSVSRQVLYLTGGTTAWVAAGHPLETELRCLSQPIDVYKRPYEGTSNARKDMQGYLDWEYGLVAQLANDGVACFHVVRDSREKLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W6QKN7</accession>
    <name>W6QKN7_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ribosomal protein L14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PROQFM164_S06g000344</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the eukaryotic ribosomal protein eL14 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792020">
        <property type="protein sequence ID" value="CDM37383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QKN7"/>
    <dbReference type="STRING" id="1365484.W6QKN7"/>
    <dbReference type="OMA" id="KLCFVVD"/>
    <dbReference type="OrthoDB" id="1875589at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23702">
        <property type="entry name" value="eL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000030">
        <property type="entry name" value="60S ribosomal protein L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039660">
        <property type="entry name" value="Ribosomal_eL14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002784">
        <property type="entry name" value="Ribosomal_eL14_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11127">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11127:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00467">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01929">
        <property type="entry name" value="Ribosomal_L14e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 8" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="KOW" evidence="7">
        <location>
            <begin position="13"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM37383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="148" mass="16781" checksum="FC8512D932D2A44C" modified="2014-04-16" version="1">MADIDVKVASWKLVEVGRLVLIRSGPFEGKLAAIVEIVDHRRVLVDGPSTEEQKIVPRHVLPLAHATLTHFTIPKLPRAAGTGPVKKLWAKNEIDGKWAKSTFAQRTDRSERRKNLSDFERFKVLRLRKQARYEVQKSHAKARAANKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>W6QL30</accession>
    <name>W6QL30_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glycine cleavage system P protein</fullName>
            <ecNumber evidence="7">1.4.4.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">GDCSP</name>
        <name evidence="11" type="ORF">PROQFM164_S03g001621</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">The glycine cleavage system catalyzes the degradation of glycine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 7">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[glycine-cleavage complex H protein] + glycine + H(+) = N(6)-[(R)-S(8)-aminomethyldihydrolipoyl]-L-lysyl-[glycine-cleavage complex H protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:24304"/>
            <dbReference type="Rhea" id="RHEA-COMP:10494"/>
            <dbReference type="Rhea" id="RHEA-COMP:10495"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83143"/>
            <dbReference type="EC" id="1.4.4.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6 7">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="7">The glycine cleavage system is composed of four proteins: P, T, L and H.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the GcvP family.</text>
    </comment>
    <dbReference type="EC" id="1.4.4.2" evidence="7"/>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QL30"/>
    <dbReference type="STRING" id="1365484.W6QL30"/>
    <dbReference type="OMA" id="RNLICTC"/>
    <dbReference type="OrthoDB" id="6537869at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005960">
        <property type="term" value="C:glycine cleavage complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016594">
        <property type="term" value="F:glycine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004375">
        <property type="term" value="F:glycine dehydrogenase (decarboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019464">
        <property type="term" value="P:glycine decarboxylation via glycine cleavage system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00613">
        <property type="entry name" value="GDC-P"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000005">
        <property type="entry name" value="Glycine dehydrogenase (decarboxylating), mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000007">
        <property type="entry name" value="glycine dehydrogenase (Decarboxylating), mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000007">
        <property type="entry name" value="Glycine dehydrogenase (decarboxylating), mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003437">
        <property type="entry name" value="GcvP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049316">
        <property type="entry name" value="GDC-P_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049315">
        <property type="entry name" value="GDC-P_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020581">
        <property type="entry name" value="GDC_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00461">
        <property type="entry name" value="gcvP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003346">
        <property type="entry name" value="PRK04366.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11773:SF1">
        <property type="entry name" value="GLYCINE DEHYDROGENASE (DECARBOXYLATING), MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11773">
        <property type="entry name" value="GLYCINE DEHYDROGENASE, DECARBOXYLATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21478">
        <property type="entry name" value="GcvP2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02347">
        <property type="entry name" value="GDC-P"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 6 7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Glycine cleavage system P-protein N-terminal" evidence="9">
        <location>
            <begin position="75"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="domain" description="Glycine cleavage system P-protein N-terminal" evidence="9">
        <location>
            <begin position="555"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="domain" description="Glycine dehydrogenase C-terminal" evidence="10">
        <location>
            <begin position="878"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="31"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="31"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="6">
        <location>
            <position position="802"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR603437-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF21478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDM34894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="1057" mass="115192" checksum="019E11AA66171F02" modified="2014-04-16" version="1">MAASLFALRGGRQLALRSRVRVPSIARSSLSPLNTRRPLTTSQPVPRRAVHTSSVSDNGEIHPKDIFQPLDTFPRRHIGPSPDAAAEMLAVLDPPVGSLDEFVKQVLPADILSTKDLKVSEPHADISLYRSSELGGLGETDMLKLLDTYRKQIDISGKTYIGTGYYPTIVPPVIQRNVLENPAWYTSYTPYQPEISQGRLESLLNFQTLTADLTGMAFANASVLDEATAAAEAMTMSYATMPTSKQKKAEKSFVVSHLCHPQTIAVMKSRADGFGINLVIGDILADDFKIVKDQKDHLIGVLAQYPDTEGGIYDFQALGDSIHGQGGTFCVATDLLALTVLKAPGEFGADIAFGSAQRLGVPMGFGGPHASFFACADKYKRKVPGRVVGVSKDRLGNRALRLALQTREQHIRREKATSNICTAQALLANMTAMYAIYHGPAGLKAIAQRIMSMTSLLREKLVSLGYDVPVRSNSADGGVVFDTLTIELPSAAEADAIMAEARAASVYLRRLGGNKVGLSLDETVGRDEVKGILNVFAAHKSASPVEVDGTLGLATIPASLERTSSYLTHPVFNTYHSETEMLRYIHHLESKDLSLAHSMIPLGSCTMKLNATTEMIPISWPEFSQIHPFMPAEQAKGYTKMIDDLERQLADITGMAEVTVQPNSGAQGEFAGLRVVKKYFEAKGDAKRNVCLIPVSAHGTNPASAAMAGMRVVSIKCDTKTGNLDLEDLKAKCEKHKDELAAFMITYPSTFGVFEPGAKEACRLVHEHGGQVYMDGANMNAQIGLCSPGEIGADVCHLNLHKTFCIPHGGGGPGVGPIGVGEHLRPFLPSHPISEYLQSKRGDTFSPPISAAPWGSASILPITFNYINMMGDRGLTHATKITLLNANYILSRLKPYYSILYTNEHGRCAHEFILDVRPFKETSGVEAIDIAKRLQDYGFHAPTMSWPVSNTLMIEPTESESKAELDRFCDALISIRQEISEVESGAQPREGNVLKMSPHTQRDLLITEWDRPYTREKAAYPLPLLLEKKFWPTVTRVDDAFGDQNLFCTCGPVEDTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W6QLG6</accession>
    <name>W6QLG6_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S03</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S03g001786</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM35059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QLG6"/>
    <dbReference type="STRING" id="1365484.W6QLG6"/>
    <dbReference type="OMA" id="PNEYRIR"/>
    <dbReference type="OrthoDB" id="2624308at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM35059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="415" mass="47607" checksum="2D1C53B993E01D53" modified="2014-04-16" version="1">MFWALGPRSKKKNVTSSTPLHGGATSSTSLIRKNHSRAQVEIRFKYPVGAVIILVLPRYNGQYEPFRYHYWGYTPISSNPYECPTLPENPDPAHEQRNPTSERLERPQFLCFLRETYSSNTLKVSNWEKKHRDTKTLQYIFIAYTTIQFSHDQKRDDMEVLHSIAEKAARRAGVQVYWLACSCMPEDKYLADDVYRISDVVRGAHSLVNAVGPPGQGHESRVYTTRELLKEWGRRMWAFPEVLLSPNTHPILIYTHGTSEGEPWQKPKSKFPSEAWVDASNSRQLVGHYEGSIMLSPLELVTIAFQCLSTRPLKEESEADIAYVFMGLLRRRPRVNLSDSAFQSFSRLSISNDSDKLLERLICLLPKSTKRKWYVIDDIWDRNLWDVDPFCPVVGVCLGDSVVLSGAFGASIRWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W6QLH5</accession>
    <name>W6QLH5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DNA-directed RNA polymerases I, II, and III subunit RPABC4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">RPC10</name>
        <name evidence="6" type="ORF">PROQFM164_S05g000659</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the archaeal Rpo12/eukaryotic RPC10 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QLH5"/>
    <dbReference type="STRING" id="1365484.W6QLH5"/>
    <dbReference type="OMA" id="MTYICGD"/>
    <dbReference type="OrthoDB" id="5585087at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.30:FF:000003">
        <property type="entry name" value="DNA-directed RNA polymerases I, II, and III subunit RPABC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.30">
        <property type="entry name" value="RNA polymerase ii, chain L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006591">
        <property type="entry name" value="RNAP_P/RPABC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039747">
        <property type="entry name" value="RPABC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029040">
        <property type="entry name" value="RPABC4/Spt4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12056">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12056:SF2">
        <property type="entry name" value="GEO11084P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03604">
        <property type="entry name" value="Zn_ribbon_RPAB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00659">
        <property type="entry name" value="RPOLCX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63393">
        <property type="entry name" value="RNA polymerase subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDM36826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="78" mass="8750" checksum="3B8EA1A7BEFDF04A" modified="2014-04-16" version="1">MSRETYQVPAMGTQNNFDTQAGGFGSAMAIDSPSVTYLCGECSARVPLKRGDQIRCKDCGHRVLYKERTKRMVQFQAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W6QM05</accession>
    <name>W6QM05_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S06g000442</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792020">
        <property type="protein sequence ID" value="CDM37480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QM05"/>
    <dbReference type="OrthoDB" id="10478051at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM37480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="63" mass="7096" checksum="F3AAB376DB1E5F5F" modified="2014-04-16" version="1">MDIMHIYGASPLSQPSWNVFPSSSQDKTQHSRRQILTSSADPPCAFFTCTFPAQLPSRPRRLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W6QM11</accession>
    <name>W6QM11_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S02g000752</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QM11"/>
    <dbReference type="OMA" id="ADQLYLH"/>
    <dbReference type="OrthoDB" id="5537330at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="entry name" value="AhpD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052999">
        <property type="entry name" value="PTS1_Protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28180">
        <property type="entry name" value="CONSERVED MITOCHONDRIAL PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28180:SF5">
        <property type="entry name" value="DNA POLYMERASE ALPHA SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="AhpD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM30602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="275" mass="31481" checksum="D619BDBA33A3531C" modified="2014-04-16" version="1">MFSRLPIRAGNFLQLKPKIVSILLPYQPRTTMSFSTATTAEVQPGYRQLFTELENRFKTTSLGSDKWYILAITTLAAGPDPERADQLYLHLTQQAEYATSAARQALIRRLREALVKAVPIIGVCKPIESILAITEVERDEDKDFTFTREGWQCDEANHERGTGWLQKLYARNTTGTLDLFSAHKDFSWLSKEITYGLFLSDRQILDDVDTELVVLPGIMIQNLPKETHWHIRGTRRLGVPKEEVQVIWDCVQLVAQFFDIKLHKVPTVEAVEYDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W6QMB9</accession>
    <name>W6QMB9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Probable transposable element</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S02g000867</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QMB9"/>
    <dbReference type="STRING" id="1365484.W6QMB9"/>
    <dbReference type="OMA" id="WITTIEC"/>
    <dbReference type="OrthoDB" id="4324149at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM30717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="296" mass="33808" checksum="D71615691E8D74ED" modified="2014-04-16" version="1">MGPLITISANQILNGDGNDTTVSKAWVDRFIKRLPDDLKPPKARSVKKKRLDASDQETLEHWYGRLKAVIAGVSPENIYNFDDTIFQIGEGVKPQMVVTSMGLGFASHQTRTYCEWITTIECIAADGWAADPFILIQGDHYYDEWLEYGGAPDEAVFMVNPSGRVKEQVACEWIECFHRQTKDRTADGQSRLLLFRGQPQYLSYKFLPFCEQHKIIPFSFPPNIGHLIQPFDSKPFKNYKQYWRSQGLIAYMIDDPDDEKTAFINGLPKIREESFKPQVITDAFADRGIVPFDPSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W6QMJ1</accession>
    <name>W6QMJ1_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">nrc-2</name>
        <name evidence="12" type="ORF">PROQFM164_S02g000932</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QMJ1"/>
    <dbReference type="STRING" id="1365484.W6QMJ1"/>
    <dbReference type="OMA" id="HTGAPQI"/>
    <dbReference type="OrthoDB" id="432483at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05574">
        <property type="entry name" value="STKc_phototropin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000121">
        <property type="entry name" value="Serine/threonine-protein kinase nrc-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000078">
        <property type="entry name" value="Serine/threonine-protein kinase nrc-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45637">
        <property type="entry name" value="FLIPPASE KINASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="258"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="203"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="49"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="65"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDM30782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="631" mass="69048" checksum="160B67751CDD47CF" modified="2014-04-16" version="1">MTQLFASSPPAVTNNEKRGNFPALSIPTRKHSNESSHLPTRIKNFFRINSSSSHSSPHPNPSGSSERERERDNHGAAKNEKSAFRQSRFLPGIGRNRSTTVASEGNPLDDAMSPTASANPYFAHQGQPALRHRNDGSVPSSPPDTPELQVTGVSAVEQATTANKEELARKLRRVASAPNAQGLFTSGQGGRPQTAQLGKEPLVEKSGGSMGFADPGSDHSNLAIPSVSSDYNSNAAFRRTYSSNSIKVRNVEVGPASFDKIKLIGKGDVGKVYLVREKKSGRLYAMKVLSKKEMIKRNKIKRALAEQEILATSNHPFIVTLYHSFQSEDYLYLCMEYCSGGEFFRTLQTRPGKSISEDAARFYAAEVIAALEYLHLMGFIYRDLKPENILLHQSGHIMLSDFDLSKQSGPGGAPTMIPARSGGNSNTGLPTIDTKSCIADFRTNSFVGTEEYIAPEVIKGCGHTSAVDWWTLGILIYEMLYGTTPFKGKNRNATFASILRDEVNFPEHSGAQPTSTMCKSLIRKLLIKDETKRLGARAGASDVKAHPFFRQTQWALIRHMKPPMIPHQGRAGTDTVNFRNVKESASVDIGGTDSTRMKGVPMDSGLATPNGELNDPFEEFNSVTLHHEGDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W6QML2</accession>
    <name>W6QML2_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase G1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S09g000034</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792023">
        <property type="protein sequence ID" value="CDM38118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QML2"/>
    <dbReference type="STRING" id="1365484.W6QML2"/>
    <dbReference type="OMA" id="WIVEDFN"/>
    <dbReference type="OrthoDB" id="2862635at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070007">
        <property type="term" value="F:glutamic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13426">
        <property type="entry name" value="Peptidase_G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.700">
        <property type="entry name" value="Peptidase G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000250">
        <property type="entry name" value="Peptidase_G1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038656">
        <property type="entry name" value="Peptidase_G1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37536:SF1">
        <property type="entry name" value="ASPERGILLOPEPSIN, PUTAITVE (AFU_ORTHOLOGUE AFUA_7G01200)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37536">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_3G02970)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01828">
        <property type="entry name" value="Peptidase_A4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00977">
        <property type="entry name" value="SCYTLDPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004879951" evidence="2">
        <location>
            <begin position="21"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR600250-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM38118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="270" mass="28601" checksum="9B1968F4559A3E46" modified="2014-04-16" version="1">MKFTTTTILTTAILAGSSLAAPRSGLVDRLQTRGALSRQSLPAEKKGVLLREGTEGVNVQYSKNWAGVVREKPPASATYTAVSATFTVPEPTATDGSGDMQAVSAWVGIDGDTYTKAILQTGIDAYIQNGKKTFDAWYEWYPLSAENFDLALSAGDVIVAKVETDSPSKGVAIIENKSSGQSVTKTLSAPSTSATLAGQNAEWIVEDFNTGSSMVPLVNFGRIDFTGAQAEAGGTKYGVKNTAVLDIQQNGNVKAHVEVRSDTEFSVTYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W6QNL8</accession>
    <name>W6QNL8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NAD(P)-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S06g000513</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792020">
        <property type="protein sequence ID" value="CDM37551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QNL8"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM37551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="51" mass="5235" checksum="9FFACC253E5E88F4" modified="2014-04-16" version="1">MSKILTVVGATGAQGGSVVTSALKSGVALIRVSSEKVIARKKSEYSNCHKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W6QNY1</accession>
    <name>W6QNY1_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF7728 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PROQFM164_S07g000039</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792021">
        <property type="protein sequence ID" value="CDM37691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QNY1"/>
    <dbReference type="STRING" id="1365484.W6QNY1"/>
    <dbReference type="OMA" id="LRITMIT"/>
    <dbReference type="OrthoDB" id="4367799at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056145">
        <property type="entry name" value="DUF7728"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40622">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40622:SF1">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24854">
        <property type="entry name" value="DUF7728"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004879975" description="DUF7728 domain-containing protein" evidence="3">
        <location>
            <begin position="18"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="256"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7728" evidence="4">
        <location>
            <begin position="38"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDM37691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="332" mass="37016" checksum="75A8E860A4806EC9" modified="2014-04-16" version="1">MQLLWVMLSLGSALASAVPSSHQLRLPFAPSTDDLENCVRSRLSINLSIQNGSLYANDHQLYPPSVIMQLNAPLYGSADQIDPSDNTVELSYTLDVEPLQNNDMASIADMIRVRVEWFDLQNNLVSPDAVAVDLLAYQSDKYEMTRIRVEPARGSDQDGHLYEKSQPWVINYWRTQFGSVFDKPKTAETTAAPPMESPAQPDAIQVSSNENETRSAPETHFFSFWATPANLHRHAEHRHPHYRHHKNSFMRIIRPIVVPALLGVVAGLVACLVGFFIGQLLASLGVCLGWQRVLGYRSRIVSEEEGTVSEKASMLLHVYVADTAESESNDSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W6QPZ7</accession>
    <name>W6QPZ7_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Bubble protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S04g001035</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM36154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QPZ7"/>
    <dbReference type="STRING" id="1365484.W6QPZ7"/>
    <dbReference type="OMA" id="WTEIQDC"/>
    <dbReference type="OrthoDB" id="4233737at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22742">
        <property type="entry name" value="BUBL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015308">
        <property type="entry name" value="Bubble"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036334">
        <property type="entry name" value="Bubble_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09227">
        <property type="entry name" value="Bubble"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103565">
        <property type="entry name" value="Bubble protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004880004" evidence="1">
        <location>
            <begin position="19"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM36154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="88" mass="9298" checksum="CFD2D5739EA7AEAA" modified="2014-04-16" version="1">MKVTAILFTLMAATAVNASVLDKRDTCGSGYDPAQRRTNSPCQASNGDRHFCGCDRTGIVECKGGKWTEVQDCHTNSCHGGTEGGAKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W6QQ31</accession>
    <name>W6QQ31_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Homeodomain-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S19g000001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792033">
        <property type="protein sequence ID" value="CDM38565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QQ31"/>
    <dbReference type="OrthoDB" id="5398572at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0371">Homeobox</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="471"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="142"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="362"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM38565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="649" mass="73050" checksum="C618CCD360EA97F3" modified="2014-04-16" version="1">MTASVPEQPRSRGIQWPSINDYTRTINVPNLPQRQSVQPLDISSTAGEPERPQSRGIKWPSVNKIPRTIDMQKRPRRHSVRQPSSGDLPITDEEPEQHQGRRLPWEPIYDTSRKTKTPSERSTTREQSSTTQVPDETTSRQIPRTSISGGSSPTTTVLDQPRSRSLPWKSSGSTSKKRKAPSEMSTTREQSSATQVLDETPTVLDQPRPRSLPWKSKGSTLPPERRSLLSESSSSISRKTKTLSERSTAREQSSATQVPDETPSRQIPRTSMSGGGSPTTTVLDQPRSQSLPWKSSGSTSKKRKAPSEMSAIRDNSQTTQVLDQTQSTSSSLRWTSAEGTSRESMGPPARLHTQSRRDLRASATTGSRPNQQTRQVDRGHGQGADTIWNIEYTSDLDFSSRHTPQRARTSRDFSYIQRQQPSNKGDDESIWGMSSAIPSSPPPTRGNSQYRQQSLPDSEILGEEEVFHSIEEHPLRGRYSGPRDTQQGTGRDTSRSESCDPSHFAGTVIREVAYGSRHGPSFAEEREVYEEKRIQELLELGREQQHGPSRMQSHGPSRMKVRWEEAETARLIRLWMKFPMRWAYIKQLDDESEDPQLEMRTPVDCKDRMRNIKKWALKNRKTLPPEFALITLGEKDLVGIAKALAKVTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W6QQN8</accession>
    <name>W6QQN8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pentatricopeptide repeat</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S05g000227</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PPR family. P subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QQN8"/>
    <dbReference type="STRING" id="1365484.W6QQN8"/>
    <dbReference type="OMA" id="CLVFGHM"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050872">
        <property type="entry name" value="PPR_P_subfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46128">
        <property type="entry name" value="MITOCHONDRIAL GROUP I INTRON SPLICING FACTOR CCM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46128:SF329">
        <property type="entry name" value="MITOCHONDRIAL GROUP I INTRON SPLICING FACTOR DMR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM36394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="791" mass="89913" checksum="84F2A9B0A982AC1C" modified="2014-04-16" version="1">MQSHLTRRVFRAIINNEPLRFSQCHRNRLLHTITPARVRPAMSSLPYTSRRNIFVFSSDPERSQSILPSEKGLKPMADLMRALKDRSRTPPSDILAKAFQTFFTMRLETPMLISHFQARALIVTFKHLRALQGEMEEEDWQNVFSIENLEKLLDVLSESECVPQARDVVMNLARYAYQELNLDHGFGPGKISRPALGLYINILAMNGNPEDARHTLLKFWGQMSKAVPSPWLTIMKGFAMKDDLRQVRKIVDEWGNHGNKFDQASHGELVTFLVDHGQWKAAQTVYDSPIADGSEPSMAAREALIKYYLLNSRADSAEEIFKSLPNEPSEDTVGIILLWEAAKGNNASALAQRVHSWTTKNPQLEGSINIHIVNNLIQYANATQNPQLASDFMGLAGQWGLVPDSQTHILELESCIQAGDVDETLKILEEKVDTTSLTSHNLPIANKLIAMLCRSEEKDALFDQISSLLDPLFQENVRLESATIAALTHMLLYRHDLDAVSELLRPRLGSYSDEQKMPVRDALTEYITDKSQSDTDVWNAYELLKIAFPETWVSARTKIMTSFFNRKRSDLAVLVFGHMRQADEPGRRPRPDTYARCFQGLARTADATNLKLVHNMLKLDLEVDLNTRILNGLMMAYAACEMPEKSMEIFRQILQSEEGPCHKTITIFFKVCENHHNGTQEAIKMMSKVKKLEITANRPLYSAYMEALAAQCEFDLAVEAIDNMEAEIGIPPTSNTIGLFYNAIPYQYWKDEVEKWASQKYPEHWEHLMTIERTDQEDGLEFDGISNEVSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W6QQR3</accession>
    <name>W6QQR3_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S11g000004</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792025">
        <property type="protein sequence ID" value="CDM38301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QQR3"/>
    <dbReference type="STRING" id="1365484.W6QQR3"/>
    <dbReference type="OrthoDB" id="5422579at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM38301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="112" mass="12795" checksum="561A0C6C95CE9827" modified="2014-04-16" version="1">MSLAKELTYIHLSTTFNDRSHSLISEVLPIKEWPNLSHLALSRFSVNTSELIDILKLAPSSLQSLDLEFIEFPFDELCLTGLLERMREGLDWTERDQPSKPTVAIAMKGHRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W6QRT5</accession>
    <name>W6QRT5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S05g000602</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QRT5"/>
    <dbReference type="OrthoDB" id="4337824at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM36769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="69" mass="7848" checksum="52B538447478ADCE" modified="2014-04-16" version="1">MTHSIPWEVQVRSAIAPEECLRYRQTAYVRSSMDGETPRIANIGQIENVLRTIHDLAPCRLMSSILPKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W6QT18</accession>
    <name>W6QT18_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S02g002813</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QT18"/>
    <dbReference type="OrthoDB" id="10268445at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM32662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="78" mass="8865" checksum="6B1638A5E9912E06" modified="2014-04-16" version="1">MYECGPELAVRLPGEWPSIHERQGLKVQRWILDHKRHRVAVIVRMRNDSSNSCGHDIVCMNDITRIAPEAQGSPTTNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>W6QT74</accession>
    <name>W6QT74_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S02g002878</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QT74"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM32727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="178" mass="20083" checksum="B74C093CEAE20DB6" modified="2014-04-16" version="1">MGKTLAHWSNGETPASLTHYSYYLFSFLNLKLAVVYPNLTQSQIAIAQLPETLLTHSYQLCHYFPGRQSRILPKKQRRTSAKVPGRSGKQKRLGDIQRSLVNIGSQLTLPDNTSTQRNINKWFQTILAANPCQSGDSDKPAQTAHSKICEQNVYTSSILSTERYIAISKEQWLTISIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W6QTC4</accession>
    <name>W6QTC4_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA (cytosine-5-)-methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PROQFM164_S06g000335</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.37" evidence="1"/>
    <dbReference type="EMBL" id="HG792020">
        <property type="protein sequence ID" value="CDM37374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QTC4"/>
    <dbReference type="STRING" id="1365484.W6QTC4"/>
    <dbReference type="OMA" id="KPRVHTM"/>
    <dbReference type="OrthoDB" id="414133at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003886">
        <property type="term" value="F:DNA (cytosine-5-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044027">
        <property type="term" value="P:negative regulation of gene expression via chromosomal CpG island methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.120.10">
        <property type="entry name" value="DNA Methylase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050390">
        <property type="entry name" value="C5-Methyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001525">
        <property type="entry name" value="C5_MeTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10629">
        <property type="entry name" value="CYTOSINE-SPECIFIC METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10629:SF52">
        <property type="entry name" value="DNA (CYTOSINE-5)-METHYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00145">
        <property type="entry name" value="DNA_methylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00105">
        <property type="entry name" value="C5METTRFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51679">
        <property type="entry name" value="SAM_MT_C5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 5 7" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="57"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM37374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="573" mass="63684" checksum="D810F7A923875D40" modified="2014-04-16" version="1">MQEASHTFQPTEKLQIVIDLTCDDETNQAIEELTSEMTHVGAASVIVAGDDLASDRSSSGNSSLISNQSASCSPTPETMQQEIDIGGVVFKPGISLELEDGSFLRVKDMIPQPHDLLFFGRHLYRTTHPEAKTYLPKLNNELVWLTQKTDLISIKKVRRVVSIRFTNYRTDFNNLTPGDELTCRLKLTIRQNGVVIIPGNAPLSAEQCAIEWLTFAESDPGLGKRANQLRAEWRGHTVPFGEARVSSMARDLERQGVIDLTVPDRAYTFGDAYCGAGGVSCGAKQAGVKLQWAVDIDKHALETYQLNFDDVEVEHSDFFSFLTNDPKFLRVDIAHCSPPCQTWSPAHTVPCPRDDANSACVFSAGSLIRESRPRVLTMEETMGLPQRFPVIFNRVVLDMVEFGYSVRWSVLGCDEYGVPQERKRLLLIAAGPGEALPHYAQPTHGMPGHGLRPRETISSTIDNIPPDAEDHNVEAALARWALSHRPSFDRHSLARTITCGGGEYNYHPSGTRPYTSREMALLQTFPLDFQFAGRFMRKQIGNAVPPLFAKAIYGEIVKSLYKTDTEEAMGIFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W6QTH6</accession>
    <name>W6QTH6_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Protein kinase-like domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S02g002988</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QTH6"/>
    <dbReference type="STRING" id="1365484.W6QTH6"/>
    <dbReference type="OMA" id="WSHRSCE"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM32837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="429" mass="47921" checksum="DF2820682F75E6D7" modified="2014-04-16" version="1">MVVAALTRCWSHRSCEWSLHGHGNKILKKLSFEQCGHLSIRIEFLISSRLRFIMADSLFSYVLNPREHRPVIMSSNLPKDNMICDLGTIKAQYQLPISMSAPTTRESYTAATTNLTGPHRRGRLKVVTGPPKSLCLPHLCGLENIASVLIVRQESPWDTYRKVITYENAGKVTIATRRTRPSRMVAIRTYGKDNARRLIYRFGRLEHRNVLSLHECYMHEDLASFLVDDLPLTLAHVVAFPSLHECYMHEDLAFFLVDDLPLTLAHVAAFPSVYPSETELGSIICQILDGACYLSSFGLAHQSLACGDVLFGIDGIIKIASLDLYIDCTPKQSEIAYIAALPSIMMRLMQKNGKDQGLVGVNDLERWPIDSAAVEILSATETAESIRSLRNQPLLAEKHRPNDDLVVLARAALLSTSLNCIYDPGSKKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W6QTK1</accession>
    <name>W6QTK1_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Gluconate transport inducer 1/Pac2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S06g000441</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MIT1/WOR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792020">
        <property type="protein sequence ID" value="CDM37479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QTK1"/>
    <dbReference type="OMA" id="RESNPIH"/>
    <dbReference type="OrthoDB" id="5319641at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018608">
        <property type="entry name" value="Gti1/Pac2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28027">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR MIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28027:SF2">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR MIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09729">
        <property type="entry name" value="Gti1_Pac2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="96"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="281"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="126"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="327"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="362"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="376"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="409"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM37479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="471" mass="51649" checksum="BEB4D7C4B9EC5A0E" modified="2014-04-16" version="1">MVNGTAAVLEPTFTGYVATTQDALILFEACLTGVLHHVPRRPHDRERSHLVRSGSVFIYEENASGIKRWTDGVTWSPSRILGNFLVYRELDKPFPPGEKKRAMKKATRRPVPAGRPGEPYPRHDSSQGYSPTSPNSAPFSDRSSHQSELERALVGSLVDSYGFKDSGLVKKTMSVTVSGVTHHLVSYYSVEDVMRGILNPPSMVDSLRFIRPRTELTQKQSFRSPIDELEANAVESQEPSHAALYGYRPQMMAPPAYAMPTPSNDFYMHPSPYAATHPPQQGPIQGYSMGAPMASPSAPNPYLPNPGQTAIPPKQEDYHSFRPYGGSMDSMSAHSMASIPGGINAGLPSSINERNRSASEHSPSAYRNSSISSRSQATDATSPMDPSTPATYSRSSFSISGQLENPHPALDRHMPGLDPNVPRRESNPIHPSYYNTDRSQYYVPGPYAATQPMSTWTTTAATQPQMAQPQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W6QUB1</accession>
    <name>W6QUB1_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Beta-xylanase</fullName>
            <ecNumber evidence="11">3.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">xlnA</name>
        <name evidence="15" type="ORF">PROQFM164_S07g000067</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-xylosidic linkages in xylans.</text>
            <dbReference type="EC" id="3.2.1.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Glycan degradation; xylan degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the glycosyl hydrolase 10 (cellulase F) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.8" evidence="11"/>
    <dbReference type="EMBL" id="HG792021">
        <property type="protein sequence ID" value="CDM37719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QUB1"/>
    <dbReference type="SMR" id="W6QUB1"/>
    <dbReference type="STRING" id="1365484.W6QUB1"/>
    <dbReference type="OMA" id="CVGFTIW"/>
    <dbReference type="OrthoDB" id="3055998at2759"/>
    <dbReference type="UniPathway" id="UPA00114"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031176">
        <property type="term" value="F:endo-1,4-beta-xylanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044846">
        <property type="entry name" value="GH10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001000">
        <property type="entry name" value="GH10_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31490:SF35">
        <property type="entry name" value="ENDO-1,4-BETA-XYLANASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31490">
        <property type="entry name" value="GLYCOSYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00331">
        <property type="entry name" value="Glyco_hydro_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00134">
        <property type="entry name" value="GLHYDRLASE10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00633">
        <property type="entry name" value="Glyco_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00562">
        <property type="entry name" value="CBM1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51760">
        <property type="entry name" value="GH10_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="11 15" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="8 11 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 12" id="KW-0732">Signal</keyword>
    <keyword evidence="6 15" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004880488" description="Beta-xylanase" evidence="12">
        <location>
            <begin position="22"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="GH10" evidence="14">
        <location>
            <begin position="20"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="13">
        <location>
            <begin position="385"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CDM37719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="420" mass="44165" checksum="DC085B8047D60964" modified="2014-04-16" version="1">MVHFSTIALALASVLPQLTNASGLNTAAVAKGKLYFGSATDNSELTDTAYLAQLSNTDDFGQITPGNAQKWDATEPSQNTFSYTKGDVIANLAATNGQKLRCHTLVWYSQLPSWVSSGSWTNATLLAAMKNHITNVVTHYKGKCYAWDVANEALNEDGTYRDNVFYQYIGEAYLPIAFATAAAADPDAKLYYNDYNIESAGSKATGAQRIVKLVQQYGAKIDGVGLQAHFIVGSTPSQSAQTTNLAAFTALGVEVAYTELDIRMTLPSTSALLAQQSTDYQNTVAACVANAKCVGVTIWDYTDKYSWVPSTFSGQGAACPWDANLVKKPAYDGILAALGGTASGTSTSSTATVTSTTTSATTTTTSATTTTTSATTTTTSSGSTTGVPLYGQCGGLGWTGSTTCTSGTCKYSNDWYSQCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W6QUR3</accession>
    <name>W6QUR3_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Trimeric LpxA-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PROQFM164_S02g003409</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM33257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QUR3"/>
    <dbReference type="STRING" id="1365484.W6QUR3"/>
    <dbReference type="OMA" id="GSPCRVK"/>
    <dbReference type="OrthoDB" id="25818at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016407">
        <property type="term" value="F:acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03357">
        <property type="entry name" value="LbH_MAT_GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018357">
        <property type="entry name" value="Hexapep_transf_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051159">
        <property type="entry name" value="Hexapeptide_acetyltransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024688">
        <property type="entry name" value="Mac_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23416:SF23">
        <property type="entry name" value="ACETYLTRANSFERASE C18B11.09C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23416">
        <property type="entry name" value="SIALIC ACID SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12464">
        <property type="entry name" value="Mac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01266">
        <property type="entry name" value="Mac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00101">
        <property type="entry name" value="HEXAPEP_TRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Maltose/galactoside acetyltransferase" evidence="4">
        <location>
            <begin position="26"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="211"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDM33257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="233" mass="25671" checksum="88D3E16B9FCB22FA" modified="2014-04-16" version="1">MAASEKRPEIIELARGLARVPLCEDYECMISGMMYNPNIPKLLEARHLCRGLAADFNNLDTKTVTYDKIGDKRLELLRKLVGKIGDGTFIEPPFLPDYGCNTSIGKDCFFNWNLTILDTSLVVIGDRVQIGTGVSLITAGHDTSVLSRRKFVEFGHPIFIEDDCWIGSNVIVLPGVRIGQGSTIGAGSVVTKDIPPFSVAVGTPCRVKKTIQSAEEEEQDPNNPYRSLVREDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W6QVC2</accession>
    <name>W6QVC2_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S08g000130</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792022">
        <property type="protein sequence ID" value="CDM38079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QVC2"/>
    <dbReference type="OrthoDB" id="10391530at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM38079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="61" mass="6918" checksum="B0BD0E8BD15A4BF2" modified="2014-04-16" version="1">MHRKGRPQGRVVVTFAGKLQPLVMKLVWSRVLDAVAWISGAGRDLLRCGESRFRLTGDRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W6QWC2</accession>
    <name>W6QWC2_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Probable mannosyltransferase KTR5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">KTR5</name>
        <name evidence="6" type="ORF">PROQFM164_S12g000068</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 15 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792026">
        <property type="protein sequence ID" value="CDM38459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QWC2"/>
    <dbReference type="STRING" id="1365484.W6QWC2"/>
    <dbReference type="OMA" id="YQHSTIQ"/>
    <dbReference type="OrthoDB" id="439943at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000032">
        <property type="term" value="P:cell wall mannoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002685">
        <property type="entry name" value="Glyco_trans_15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121">
        <property type="entry name" value="ALPHA-1,2 MANNOSYLTRANSFERASE KTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121:SF2">
        <property type="entry name" value="MANNOSYLTRANSFERASE KTR5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01793">
        <property type="entry name" value="Glyco_transf_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018153">
        <property type="entry name" value="Glyco_trans_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="39"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR018153-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDM38459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="495" mass="57631" checksum="37B8233B35E40282" modified="2014-04-16" version="1">MEHRFTATGSSHWSSVGNTDRIIPHSSFRRPGNRVQHRSCPLIIALILTLIATAFFLPRLFWNGLPSNLFLPADTPPTIKIISDKHDKVFATGCLSVTYEIQRSARMNAAFVVLVRNQELDGILQSIRSIERHFNQWFHYPYVFLNDADFDEEFKAKIKRHVSAPVEFGKVESTLWDFPDWVDPEIAREGIQKQGDADIMYGGMESYHHMCRFYSGQFYKHPLLLKYEWYWRLEPEIKYFCDITYDPFVKMAEANKTYGFTIAIKELQETVPNLFRYASAYKRTKGIKSKGLWEMFLNRPSGVKLPSSEDEKWNNLPEDITMLDSDHVHSDEICPDAMEGESYNLCHFWSNFEIARLDWYQSKEYQEFFEMMERSGGFWMERWGDAPIHSLAAGILLSPDDVHYFRDIGYRHTTIQHCPANAPARQLPRAPFLDQTIEDEKERLEEDEYWANFDSVRENGVGCRCRCDTDVVDAEDKEGSCFAEWVDVAGGWTSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>W6QXN2</accession>
    <name>W6QXN2_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">ATP-dependent 6-phosphofructokinase</fullName>
            <shortName evidence="14">ATP-PFK</shortName>
            <shortName evidence="14">Phosphofructokinase</shortName>
            <ecNumber evidence="14">2.7.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Phosphohexokinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">pfkA</name>
        <name evidence="17" type="ORF">PROQFM164_S03g001011</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14 15">
            <text>beta-D-fructose 6-phosphate + ATP = beta-D-fructose 1,6-bisphosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16109"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="14">Allosterically activated by ADP, AMP, or fructose 2,6-bisphosphate, and allosterically inhibited by ATP or citrate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 14 15">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 14">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade "E" sub-subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.11" evidence="14"/>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QXN2"/>
    <dbReference type="STRING" id="1365484.W6QXN2"/>
    <dbReference type="OMA" id="EWQDQMC"/>
    <dbReference type="OrthoDB" id="537915at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00182"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005945">
        <property type="term" value="C:6-phosphofructokinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003872">
        <property type="term" value="F:6-phosphofructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070095">
        <property type="term" value="F:fructose-6-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048029">
        <property type="term" value="F:monosaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061621">
        <property type="term" value="P:canonical glycolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030388">
        <property type="term" value="P:fructose 1,6-bisphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006002">
        <property type="term" value="P:fructose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.460:FF:000007">
        <property type="entry name" value="ATP-dependent 6-phosphofructokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.460:FF:000008">
        <property type="entry name" value="ATP-dependent 6-phosphofructokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.450">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.460">
        <property type="entry name" value="Phosphofructokinase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03184">
        <property type="entry name" value="Phosphofructokinase_I_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009161">
        <property type="entry name" value="6-Pfructokinase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022953">
        <property type="entry name" value="ATP_PFK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015912">
        <property type="entry name" value="Phosphofructokinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000023">
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <source>
            <dbReference type="EMBL" id="CDM35067.1"/>
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        <source>
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    </evidence>
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</entry>
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    <accession>W6R1F6</accession>
    <name>W6R1F6_PENRF</name>
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        <submittedName>
            <fullName evidence="3">Genomic scaffold, ProqFM164S04</fullName>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
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                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">FM164</strain>
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</entry>
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    </gene>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
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    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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        <location>
            <begin position="22"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="CDM35682.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="125" mass="13898" checksum="2D0F8E542C7FD5D9" modified="2014-04-16" version="1">MYTARVVKPKLSLSISAAQNVPRPSLSLKSPSALPRTPVSPISAASPTSKRFSSLQVPNYAYTNSCSSKSILKKQSSSRAGTVDKRIQFKGTPTVHCVTPIENPDEYYGKHMKMSREERRWTVRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W6R2K6</accession>
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        </submittedName>
    </protein>
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        </lineage>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
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                <person name="Silar P."/>
                <person name="Lacoste S."/>
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                <person name="Bensimon A."/>
                <person name="Giraud T."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7">FM164</strain>
        </source>
    </reference>
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        <text evidence="3">Belongs to the SSK1 family.</text>
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        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="1 4" id="KW-0597">Phosphoprotein</keyword>
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        <location>
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            <end position="658"/>
        </location>
    </feature>
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        </location>
    </feature>
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        </location>
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        </location>
    </feature>
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        </location>
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        <location>
            <begin position="409"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
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            <begin position="432"/>
            <end position="454"/>
        </location>
    </feature>
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        <location>
            <begin position="740"/>
            <end position="752"/>
        </location>
    </feature>
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        <location>
            <position position="546"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00093463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM36072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="768" mass="83256" checksum="BEB0751BFD919116" modified="2014-04-16" version="1">MTERISRLKAKLLGRLSPKADADPSAHFNRKPPSSPLDSNKSPAYSIASSKHLDEITPSRILQVQEPLSPGTNPELGSSVSAPSEQPHTGTRNCTPLTEPYNSTLPTPISGDLPSPLETPPLSTPQHSDTTSFQSTHLKAQTPILPETPLTPTLHTVAEWPTNDRPPTSYFPPSSKRPSLAIRRQSLLPDTHHHLISGLLDASVFSSGDQPSGFTPVVPCEMVTRRVWVKRPGGSATLVPCREDAVVDELRDHVIMKYGNSLGRSFDSPDIAIRILPREGSNRPGLTERLLSPEEILISILDAYYPGGQNIEEALVIDAPSRRTPKPSPRHSMYQYHQSEPGEHGDYFPLMPPVKVNAGTPSAHSGAPSVAANAPSISILNTGVAPLLPSPGSRRARHQRPPLTRHRTNSPTILHNQNTQTPGITETGPTPHSQPLPAPPPSMPTPPAAPPPVESPQVKSHTPPATASPRVMRKTKAATSPGAMFGGLIDGTVPPINVLIVEDNIINQKLLEAFMKRLKVRWKCAMNGEEAVRKWRQGGFHLVLMDIQLPVMNGLEATKEIRRLERLNGIGVFPKTASGRFSASSTPATERRPGLHRTVSEEDTLSDLSLFRSPVIIVALTASSLQSDRHEALAAGCNDFLTKPVGFPWLEQKVTEWGCMQALIDFEGWRKWRGFMDSPRAASPTVDTSSSPMQGGYRKEPPRVDPPSPSIPRPANKSNHFETKPTLPEAAQIMREDSWGSGSLDSIDSTSGDGAPGSDATIVPLDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W6R6W2</accession>
    <name>W6R6W2_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S06g000539</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792020">
        <property type="protein sequence ID" value="CDM37577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6R6W2"/>
    <dbReference type="STRING" id="1365484.W6R6W2"/>
    <dbReference type="OMA" id="YAICTAN"/>
    <dbReference type="OrthoDB" id="5428890at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="414"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM37577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="447" mass="50806" checksum="4F0B07B241220264" modified="2014-04-16" version="1">MKPKPATTTEDMSLDIHLEAIELLFGLGISHAKQWPGIHILCNHLERKFESLLCEEFEIIWKILKREKPSNAVHGWHWFLAVLRGIQSLQADETVSMEKIYHHLIKGNSAGFSPLEKDHTLLAIFAVLCWASMTIDPDLELGQANEASGNDRTLFLRAKYGSRPGESGEIPLGQSARRPIKKLFRAIKGTLEDTRHDGATATDILYESSVNCYSLYTIGRVRVKWVENLASHLAFDRQSRTLSVFCLPTFCASSILQTQQLNVLYQVSSELLPSNFYTDSLANDASSLHREVLLSYRLLFGQSSHSRQIALELLEQTKKLSGEIDPFLLAICSASVTQSRFLRRFTKSRIPVELFPTSNIDLYNSLIESDTYSARDDFPHFGPRLLAVQLYNLKQQPSRIRDLWRDRRNPLQWYTFWAVLWVGGISILLSVFQLAAAIVQTYYSAPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W6PQM8</accession>
    <name>W6PQM8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Zinc finger, RING/FYVE/PHD-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PROQFM164_S01g000009</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PQM8"/>
    <dbReference type="OrthoDB" id="4340602at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12906">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="168"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="234"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="278"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM26200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="318" mass="36121" checksum="6ABF5C8E1338A094" modified="2014-04-16" version="1">MPSSQERWDPLVICEMGLRRHQQTCCGLTKNGTYCKLYPTVNDVDEGRNKLKSLARRQFDLSDLPILRDIASHFLCRRWHRTRQADQLGQQWYDAAVRNIPYIPVAAPVRPETTRITRRHVTRDMLRENNVPWRISSTRPATYSIERGSHSLRLKSLNDLPVSEHMNCLICLQEAQADPVVLKCGRCVFFVHLSCMETWLGFSPPENNPPCPICKHNGAFDAFICSLRTDGPSGETRIDESVSSEQQIHRSTRSVDRSVDRSSPGRSATDGLAVKSQPIVSTQRRSARLAQQTDPSGSSDLSELRRSARRGQPPERFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W6PRE6</accession>
    <name>W6PRE6_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein CSN12 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">csn12</name>
        <name evidence="4" type="ORF">PROQFM164_S01g000259</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CSN12 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PRE6"/>
    <dbReference type="STRING" id="1365484.W6PRE6"/>
    <dbReference type="OMA" id="INRMFTL"/>
    <dbReference type="OrthoDB" id="10252687at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000366">
        <property type="entry name" value="COP9 signalosome complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045114">
        <property type="entry name" value="Csn12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12732:SF0">
        <property type="entry name" value="PCI DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12732">
        <property type="entry name" value="UNCHARACTERIZED PROTEASOME COMPONENT REGION PCI-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00753">
        <property type="entry name" value="PAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="3">
        <location>
            <begin position="247"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00025771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00073854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM26450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="453" mass="50762" checksum="2B7B88B81CA134F9" modified="2014-04-16" version="1">MTSLPTAFKNAYLNGSGPELAAVLTPIAPSEDRDRLRSFYQFSNAEYISKDLSYALFHGKSLKLPKAEQNAWVDIFAVYWEAIGEILRCEDHLPGASVVTVFNAWKKVANALIRGYSGSAGIPAWTLPCLYTVGKYLRTFAINADLEAASQGSTGFGFQDDIAADVEKNANLEEAARVINRMFTLCLSDRAPPEESRKWGIYNMTNLLFKTYFKINSVGLTKNLLRAIKASSADLPPPEAFPKAHIVTFEYYVGVIHFLDENYPEAEEHLTWAWKMCHRDATKNRELILTYLIPCHLVTTHTLPTKELLAPFPRLEKLFRSLSNCIRKGDLVGFDQAMSDGEEEFVKRRIYLPLERGRDIALRNLFRKVFLAGGFDEPKESQSPVRRTRVHVNEFAAALRVGTSTSGRSRIDIDEVECLLSNLIYKGLMKGYIARDRGIIVLSKGGAFPGTGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W6PS75</accession>
    <name>W6PS75_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PROQFM164_S01g000415</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PS75"/>
    <dbReference type="STRING" id="1365484.W6PS75"/>
    <dbReference type="OMA" id="LFFVHHR"/>
    <dbReference type="OrthoDB" id="5215911at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
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        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="102"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <begin position="204"/>
            <end position="221"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="6">
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    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="362"/>
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    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="508"/>
        </location>
    </feature>
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        <location>
            <begin position="520"/>
            <end position="542"/>
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    </feature>
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        <location>
            <begin position="60"/>
            <end position="545"/>
        </location>
    </feature>
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        <location>
            <begin position="280"/>
            <end position="300"/>
        </location>
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    </evidence>
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            <dbReference type="PROSITE" id="PS50850"/>
        </source>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="563" mass="62064" checksum="B9C363E935DF8124" modified="2014-04-16" version="1">MDRFHAVSSFEDEIDQPPGTFKLIGDDAGDEDGQCMVLLYPIPSSDPNVPLNWSTMRKSVNFTIVLAMTIVIFTALSIQAIFWQQMTVDLEVTYTELNKAMSVNFVGLTTGCIFFIPLAKKYGRRPVYIVSTALMLTTSFWTSKMNSLTELYLTNLLQGLAGATNESIAEITVSYVFGPIVRCPVNVVQIADLFFVHDRGSMNGLYLTCVMIGSFLTPMAAGAQATQYGWRSSYQTMGIFNGVLFVLFLFIYEETKFVSVFIGQARATVEEADQLVSIREDGSDNFDSGSSAKGPSVTEHTRSHHVLDLTIPRNSWRKRLALVTPTPEPIWPHFYRPFCVLIFPAVAFAAFQYAAGIAWLTVTSSVLSLTFPEPPYLFSPAQIGYTSAGPLVGNIIGAVYGGFLGDRSILYYAKRNRGYYEPEMRLYILHLPAIFMTGGLIMFGATISRGMHWIWPNIAGAFFGFGLGSISDAALVLVMDSYREITGDAFTAVTFMRNAVGIAIPFAISPWIQRNGIQNMFIACGMLSLAITGTIIPMVLWGKSGRRALAGRYRDIVKNGHAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W6PSQ9</accession>
    <name>W6PSQ9_PENRF</name>
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        <submittedName>
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        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rpl18a</name>
        <name evidence="6" type="ORF">PROQFM164_S01g000714</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL18 family.</text>
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        <property type="protein sequence ID" value="CDM26905.1"/>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.100.10.10:FF:000001">
        <property type="entry name" value="60S ribosomal protein L18"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal_eL18"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal_uL15/eL18"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal_uL15/eL18_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10934">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10934:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17135">
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    </dbReference>
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        <property type="entry name" value="Ribosomal proteins L15p and L18e"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
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    <feature type="domain" description="Large ribosomal subunit protein uL15/eL18" evidence="5">
        <location>
            <begin position="2"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="162"/>
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        </location>
    </feature>
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        <location>
            <begin position="174"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006815"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF17135"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CDM26905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="184" mass="20595" checksum="9574BCD1670DA3F8" modified="2014-04-16" version="1">MGIDLDRHHVRSSHRKAPKSDNVYLKVLVKLYRFLARRTESNFNKAVLRRLFMSRINRPPVSLSRAVANISEAQKGKTVVVVGTVTDDNRLLTVPKLSIAALRFTATARARIEKAGGETLTLDQLALRAPTGANTLLLRGPKNAREAVKHFGFGPHTDKKPYVASKGRKFERARGRRRSKGFKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W6PTK3</accession>
    <name>W6PTK3_PENRF</name>
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        <submittedName>
            <fullName evidence="7">Zinc finger, RING-CH-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PROQFM164_S01g001349</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PTK3"/>
    <dbReference type="STRING" id="1365484.W6PTK3"/>
    <dbReference type="OMA" id="PANYDSQ"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16461">
        <property type="entry name" value="RING-H2_EL5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45969:SF69">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12190)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45969">
        <property type="entry name" value="RING ZINC FINGER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00744">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="753"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="273"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="377"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="468"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="801"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="30"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="56"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="273"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="416"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="479"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="562"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="581"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="801"/>
            <end position="814"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM27538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="830" mass="89063" checksum="6E09147C41115E7B" modified="2014-04-16" version="1">MGQSSSTQRDPSNNGYRVHFAPFSIQRGPNTRDENMNHRQAAEHNGEGGLPPRPDMNIHNRSDQDMASDRPGRTSAGGSQPMRSIEEEGGPEYELPPREYRTAAFARMAARRQSTMSRLGSRLLPNSVIRGLLNSQEETPAEGHAHRHGLVSPRAETAQTSGRFSAFDSFGSRGITRRRSARAPYFIPPRPESAGIPDAPATPTYIDSPSQIPDPTRASWRRSVRLQRMRHSISSPISHMFGQPHSDLRPHESPEYPMSDPLFDDRAMDTRLDFGEPPHELESLEPSIQAERPVTDSSSAQPSPALMRRLPGIIRARSSRVLRREEQTPLSRVLQLAASAIAAQLSGTAGPALPNIQALGNDGLDGSLENFIQSLQHATSAQAQPPAADGSSSTANEGPSHPVNFLRVFRFANSEPSTSGAARQSASGVGDHGTQTDGMDIDEPAEGAGRTVTLVVVGVRSVLAGNAGHTEQQQPVSPGPGLDALLGLPFLPHNTTIPRPQDATGEPTQRSDGRSRLTLPRNPTGATELPRPSVPNHFRRMSDTGPRAGFPSYHPSGFSESPPGPHPPPSTPAEQGISALSSGTSTPSRRPSSASAIAPDILPHLHEGQAMRPTAETLDEPVTFNTARQRRRSDSEYARHRALGSGAVRRNGMVEPDQPPPSGGRSWLIYVVGTNLSENHPALTTPSLFTDNPTYEDMILLSSLLGPAKPPVASQTDINSAGGIFRLVEYAGSLVAEAVEGAASIQIQDGERCLICLSDYEVAEEVRELNKCKHVFHKDCIDQWLTTGRNSCPLCRGQGVNETPSNDSNTDNSVPSPAPAPAPAPDGTAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W6PUW9</accession>
    <name>W6PUW9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g001839</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PUW9"/>
    <dbReference type="STRING" id="1365484.W6PUW9"/>
    <dbReference type="OMA" id="IGNWQQM"/>
    <dbReference type="OrthoDB" id="4590138at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39474:SF1">
        <property type="entry name" value="FUNGAL SPECIFIC TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39474">
        <property type="entry name" value="UNNAMED PRODUCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="74"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM28028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="211" mass="22873" checksum="A0FEDF1D1839613E" modified="2014-04-16" version="1">MQVSRTVYRAALLHLSVNPFVRATISAGSTTWTSLNAPTTQSPNTRLYSILFPQCTTSFKASDCTHQTRTMCDSTSNPNSNSAAAASSNPATQNQQTQNQQTQNQEIQEQEQESQPEKHLYLPASDPLNPIANQQGDGSIKLDMSGGGTAVKLDHLGPMVVNVDGTLSQIGNWQQMTEIEKSNTLRVLGKRNQKRLEALRAKEAEGGSGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W6PUY4</accession>
    <name>W6PUY4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g001511</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PUY4"/>
    <dbReference type="OMA" id="ERPWWFG"/>
    <dbReference type="OrthoDB" id="291792at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026749">
        <property type="entry name" value="Tmem135"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12459:SF19">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 135 N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12459">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 135-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="387"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="422"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM27700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="535" mass="59329" checksum="ACF9A33DC5C4289A" modified="2014-04-16" version="1">MSADNPPVPGDALDLPPRALRDVLRVCLSAKEYRFLHESVVRRAPTIQNKLPSPSRYDVIARPKNRHSEAAIRSSLRVFVGSGIALKLADLLITRFQGASQKKTRTPLFRSPKFRLSISLSLLLLIHRLLYRFLVRLRANLRTDDAKPFRERNPYVSQALTSRFAPAIGASLAGFALGICPQDQLRLTAAIYTGTRSLEFLFNVLDSKGWLDRRPWWFGSWLLMPISFAQLFHAFVFDRETTPNWFGKVIFRLSPSYIQGRPESLPVNIAWPEKEEIVNSLASIADLRWPAFVSPILHPGDLNTLPSSVASISPITGPAHPAITSLSCALLHPKLPNCSTAFLHHILLSVPPLARFLTTITLALSIPKFKSILLQPISSVNTISKRIITMTAVISAAIGSAWGSVCLLNHNLPRTTLPTKRFFLSGALGGLPFLFLGNSRSTFLWFFRVAVDSAYKTGVKRGLWKGRKGGELLLFVLSWALMGSILEGNPEAVQGGGLRKALTWLRGDGFADPVDIAKRRLRRESKKADGSEFTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W6PV16</accession>
    <name>W6PV16_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA repair protein rad9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PROQFM164_S01g001447</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Acts in DNA repair and mutagenesis. Involved in promoting resistance to ionizing radiation and UV light, as well as regulating cell cycle progression after irradiation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the rad9 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PV16"/>
    <dbReference type="STRING" id="1365484.W6PV16"/>
    <dbReference type="OMA" id="NETQCRF"/>
    <dbReference type="OrthoDB" id="60092at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030896">
        <property type="term" value="C:checkpoint clamp complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071479">
        <property type="term" value="P:cellular response to ionizing radiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000076">
        <property type="term" value="P:DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031573">
        <property type="term" value="P:mitotic intra-S DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.70.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046938">
        <property type="entry name" value="DNA_clamp_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026584">
        <property type="entry name" value="Rad9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007268">
        <property type="entry name" value="Rad9/Ddc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15237:SF0">
        <property type="entry name" value="CELL CYCLE CHECKPOINT CONTROL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15237">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04139">
        <property type="entry name" value="Rad9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009303">
        <property type="entry name" value="Cell_cycle_RAD9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55979">
        <property type="entry name" value="DNA clamp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004881604" description="DNA repair protein rad9" evidence="4">
        <location>
            <begin position="20"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="287"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="416"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="293"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="343"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR009303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDM27636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="445" mass="49529" checksum="C129C2B5983E754A" modified="2014-04-16" version="1">MTSLSLSLGPLALVRLHDALICLSKFSETVAIEAEPDILRLSALNSTKTGFASFAFEKGVFFEAYSFNSSSNGRSGSVSLDRFFCQIYNKALLSIFRGKTDRNKDTAVERCDMELHEDLQQAECRLTVKMICGLGVIKSYKLTYEPAAIQHAIFDKSRVTSMWTADPRFLKQLIEHFSLSAEQLDMYSDSGRAVFTSFTTKITEGKEVLKHPVHTSVAADTRDFQEYLVEENMHVAINLKDFKAVVAHAETANASVTARYTRPCKPLQLEYGFEGINAEFTVMTRGQADSEDAPTSTRASIPRQTPVPIPISASRSRDTRPSVTTNTQMPPPPPRTRSIRPLNGSSTQENLSQRASADRPAASGLSMEFDSLFVPADDDRQWDEMKDEEEPQDILGWDASGTQDAFGATIRDAEPALLREDEPNDETGLPPTQRFSQVRQYGFFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W6PVF1</accession>
    <name>W6PVF1_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S01g001552</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PVF1"/>
    <dbReference type="STRING" id="1365484.W6PVF1"/>
    <dbReference type="OrthoDB" id="4326688at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM27741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="236" mass="26639" checksum="63663CA60CD258A4" modified="2014-04-16" version="1">MAAYRSGHLVWDKEKVTYWAHGKMVGGPKKMEMEEFYALSRQLGPAGIWVEGMDDYKPEPMYLFFYMPPLQRGYAMHEFIVSIRNPNTWQKNTWQHTVHLNVIEDTGAIAMKIHQSDRLYIERLSGAGLPVTGTTRMGTAAGEVPVDNVVLQVNIFHNDQPLLPRWTDIRACISRGPRNASTGLRLSGLWLHHMLYCLSVPNNSEAMYVGTDLPEILANVPLCNPAYAIPPCTDPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W6PVQ9</accession>
    <name>W6PVQ9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S01g002114</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PVQ9"/>
    <dbReference type="OMA" id="DHYYLAD"/>
    <dbReference type="OrthoDB" id="10364656at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM28303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="130" mass="14809" checksum="99F03CE7690A57DC" modified="2014-04-16" version="1">MGQSSSRYLNVYIVYTLCTPSGHPTRSALFVSEEGSSTGDHYYLADDAVWGYCYNRERVTYSTQHPKFKGTELVFTGTTRLRRYPKSWDSLLCNLPAERLSGKQMVAMSREKAEDLLCHEALTLLRINIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W6PVU1</accession>
    <name>W6PVU1_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g001707</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PVU1"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="25"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM27896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="72" mass="8342" checksum="30186129F5B3797E" modified="2014-04-16" version="1">MNATRATPNITVEKQSSTSAGHAWQNQQRQTWQQGHYQNQYQAKQQQQQLAPAQQNPQPRTSQNQLRISDRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>W6PWE6</accession>
    <name>W6PWE6_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Multifunctional tryptophan biosynthesis protein</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="16">Anthranilate synthase component 2</fullName>
                <shortName evidence="16">AS</shortName>
                <ecNumber evidence="16">4.1.3.27</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="16">Anthranilate synthase, glutamine amidotransferase component</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="16">Indole-3-glycerol phosphate synthase</fullName>
                <shortName evidence="16">IGPS</shortName>
                <ecNumber evidence="16">4.1.1.48</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="16">N-(5'-phosphoribosyl)anthranilate isomerase</fullName>
                <shortName evidence="16">PRAI</shortName>
                <ecNumber evidence="16">5.3.1.24</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="20" type="primary">trpC</name>
        <name evidence="20" type="ORF">PROQFM164_S01g002394</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 16">Trifunctional enzyme bearing the Gln amidotransferase (GATase) domain of anthranilate synthase, indole-glycerolphosphate synthase, and phosphoribosylanthranilate isomerase activities.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 16">
            <text>1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate + H(+) = (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:23476"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58613"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="EC" id="4.1.1.48"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 16">
            <text>N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:21540"/>
            <dbReference type="ChEBI" id="CHEBI:18277"/>
            <dbReference type="ChEBI" id="CHEBI:58613"/>
            <dbReference type="EC" id="5.3.1.24"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 16">
            <text>chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21732"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="4.1.3.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6 16">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 1/5.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 16">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 3/5.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5 16">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 4/5.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.27" evidence="16"/>
    <dbReference type="EC" id="4.1.1.48" evidence="16"/>
    <dbReference type="EC" id="5.3.1.24" evidence="16"/>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PWE6"/>
    <dbReference type="STRING" id="1365484.W6PWE6"/>
    <dbReference type="OMA" id="EPIEWAN"/>
    <dbReference type="OrthoDB" id="524799at2759"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004049">
        <property type="term" value="F:anthranilate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004425">
        <property type="term" value="F:indole-3-glycerol-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004640">
        <property type="term" value="F:phosphoribosylanthranilate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:L-tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01743">
        <property type="entry name" value="GATase1_Anthranilate_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00331">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00405">
        <property type="entry name" value="PRAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000136">
        <property type="entry name" value="Multifunctional tryptophan biosynthesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000031">
        <property type="entry name" value="Multifunctional tryptophan biosynthesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00135">
        <property type="entry name" value="PRAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050472">
        <property type="entry name" value="Anth_synth/Amidotransfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016302">
        <property type="entry name" value="Anthranilate_synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013798">
        <property type="entry name" value="Indole-3-glycerol_P_synth_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001468">
        <property type="entry name" value="Indole-3-GlycerolPSynthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001240">
        <property type="entry name" value="PRAI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006221">
        <property type="entry name" value="TrpG/PapA_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001377">
        <property type="entry name" value="PRK00278.2-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00566">
        <property type="entry name" value="trpG_papA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43418:SF4">
        <property type="entry name" value="MULTIFUNCTIONAL TRYPTOPHAN BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43418">
        <property type="entry name" value="MULTIFUNCTIONAL TRYPTOPHAN BIOSYNTHESIS PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00218">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00697">
        <property type="entry name" value="PRAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001382">
        <property type="entry name" value="TrpG-trpC-trpF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00097">
        <property type="entry name" value="ANTSNTHASEII"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00099">
        <property type="entry name" value="CPSGATASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00096">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00614">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 16" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="11 16" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="8 16" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="10" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="12 16" id="KW-0413">Isomerase</keyword>
    <keyword evidence="13 16" id="KW-0456">Lyase</keyword>
    <keyword evidence="14" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 16" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="Glutamine amidotransferase" evidence="17">
        <location>
            <begin position="26"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="Indole-3-glycerol phosphate synthase" evidence="18">
        <location>
            <begin position="240"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="domain" description="N-(5'phosphoribosyl) anthranilate isomerase (PRAI)" evidence="19">
        <location>
            <begin position="557"/>
            <end position="745"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR001382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CDM28583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="752" mass="81169" checksum="C080BF49C4148F68" modified="2014-04-16" version="1">MADLVDHSPHHATKAAKLASASNVILIDNYDSFTWNVYQYLVLEGATVTVYRNDEVTVEDLAAKKPTQLVISPGPGHPETDAGISNAAIQYFSGKIPIFGVCMGQQCMITSFGGKVDVTGEILHGKTSELKHDSKGVYQGLPTSLQVTRYHSLAGTQSTIPDCLEVTSRVELGDGSGKNIIMGIRHKEFAVEGVQFHPESILTEYGRKMFRNFLELTTGTWDNKQGAAAAAPVDKKLSILDKIYAHRKIAVDEQKKIPALRPEALQAAYDLNIAPPQLSFPERLRQSDYPLSLMAEIKRASPSKGIISADVCAPAQAREYAKAGASVISVLTEPEWFKGTIDDLRAVRQSLEGLTNRPAVLRKEFVFDEYQILEARLAGADTVLLIVKMLDIELLTRLYHYSRSLGMEPLVEVNTPEEMKIAVDLGSEVIGVNNRDLTSFEVDLGTTSRLMDQVPESTIVCALSGISGPQDVEAYKKEGVKAILVGEALMRAPDTSAFVAQLLGGSNRKSAGATPSSPLVKICGTRTEEGALAAIQAGADLIGIIMVQGRSRLVSDDVALGISRVVKSTPRSANTLQQSSNATPLEWFDHSTNILRHPSRALLVGVFMNQPLSYVISQQQKLDLDVVQLHGSEPLEWSSLIPVPVIRKFAPGDIGIARRAYHTLPLLDSGAGGSGELLEEGGVKKVLDSDDGLRVILAGGLNPDNVVDTVKKLGQSGHKVVGLDVSSGVETNGAQDLEKIRAFVKSAKSIRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W6PWZ7</accession>
    <name>W6PWZ7_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NmrA-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S01g002102</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PWZ7"/>
    <dbReference type="STRING" id="1365484.W6PWZ7"/>
    <dbReference type="OMA" id="YYMSNFT"/>
    <dbReference type="OrthoDB" id="3358371at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05251">
        <property type="entry name" value="NmrA_like_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051164">
        <property type="entry name" value="NmrA-like_oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748">
        <property type="entry name" value="NITROGEN METABOLITE REPRESSION PROTEIN NMRA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748:SF31">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="1"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM28291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="307" mass="33728" checksum="C2EE33DD19D0BA7E" modified="2014-04-16" version="1">MSKLITIFGATGNQGGSVIDAILADTQLSKEFKIRGITRDTTKKSAQDLAKRGVDVVSADLGSVDTLTAALKGSHTVFLVTNYWETMNPDIEFSQGKNVTDVSKAIGVSHLIFSSLHHVTEETKGRLSHVPHFDSKASIEKYIRASGVGCSFVLPGYYMSNFTQMLSRAEDGSYQLFYPVGKQAQFPLFDAAQDTGLFVRAAIKHAGQLKDKQILAAAKYYTPEEIVDTFSKVTGKKAVFVQVSSDQYKASLPAAIADEYLENQLFVEEPGYYLGEPLEPSLSLLDSKPTTWEEFVKKNVSAWKQVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W6PXB5</accession>
    <name>W6PXB5_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PROQFM164_S01g000413</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PXB5"/>
    <dbReference type="STRING" id="1365484.W6PXB5"/>
    <dbReference type="ESTHER" id="penro-w6pxb5">
        <property type="family name" value="Fungal_carboxylesterase_lipase"/>
    </dbReference>
    <dbReference type="OMA" id="YSTWKWF"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005151034" description="Carboxylic ester hydrolase" evidence="3">
        <location>
            <begin position="21"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="23"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDM26604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="549" mass="59771" checksum="FD51AFB6E44FA96A" modified="2014-04-16" version="1">MKLLSTLATVAACGSSIASALSPPVIDTHYGTIHGGLSPFRGGDKAFVYKGIPYAQPPTGANRWTKVAGPSKWGTLNATEFGPQCAQTISDAGIFSSGKTTTSEDCLYLNVWTPAYKNQTNMSAKKLPVLFWIYGGRFTGGSGDVKTYDGTGLAQKDIIVVTLNYRLGPFGYLAHPELTAESGHNSSGNYGILDQQAALHWVNENIQLFGGDPNQITVGGQSAGSASALDAMWSPLAEGLAEGIISESGARGTHDPMTGTVATSYRTKKAAEEQGVAFLKQMNVTSIAQLRNVSMEALLEYDSLSDTIWEGTPFANLSATFMEPPMWRPNIDGYVFTDNYSGALRNNSHADIPILTGSNKDESGASPDLSYTSSDYHDLYSNLFGDLSDDFFALYPGENSSQASQSAKEFYRDLSRVGTWRWAADWAAGGAKSNVYTYYFTHAPAENHDEGAYHGSELWYTFNNIPYASYSNVTWNSEDYAVENKMANYWANFIRTGNPNGNGLPQFKPSTKTSAKTMWLGDSWGMGPLTMNSKRIQFLQKWTSRLPAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W6PXV4</accession>
    <name>W6PXV4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S01g002576</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CRP1/MDG1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PXV4"/>
    <dbReference type="STRING" id="1365484.W6PXV4"/>
    <dbReference type="OMA" id="DQQRFSG"/>
    <dbReference type="OrthoDB" id="5873279at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031588">
        <property type="term" value="C:nucleotide-activated protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02859">
        <property type="entry name" value="E_set_AMPKbeta_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032640">
        <property type="entry name" value="AMPK1_CBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050827">
        <property type="entry name" value="CRP1_MDG1_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10343">
        <property type="entry name" value="5'-AMP-ACTIVATED PROTEIN KINASE , BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10343:SF81">
        <property type="entry name" value="CRUCIFORM DNA-RECOGNIZING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16561">
        <property type="entry name" value="AMPK1_CBM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-activated protein kinase glycogen-binding" evidence="3">
        <location>
            <begin position="5"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="110"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="367"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="462"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="506"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="583"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="610"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="367"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="396"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="463"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="518"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="555"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="592"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="614"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="646"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="684"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="709"/>
            <end position="722"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM28765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="758" mass="80666" checksum="EB349CA7D288CCD8" modified="2014-04-16" version="1">MGTFTFHWPYNASEVFVTGTFDDWGKTVKLDRVGDSFVKEVTTLPVQKVQYKFVVDGIWTTDPKAREEQDGHNNVNNVLLPEEIKASDSAPTMSGVTPYSTTAALAANVPKEPNGDLPGSFPETPGQESEQTFSVDPIPASGGYGNPVTLKPGEEVPRQSTFNNNTVGSTVTLDKESYDKGQTLPVDGYQANNTSPETFAFAPFTLPPITNNMIPESSLPIGGPSQSYTGGPAQQAALADPEYFIQSSGPTSTTAELAAGVPLESKGKANANKPVDEVPRVVKDSIAEAHKDPEATAYQEAVDEKYATENELHKKYPVENSAGRFVQPVDEVPRVVKDSMAEGYKDPEAAANLKAVDEKYATEKELQEKFPVEDSAGRQTNGHYPIPRAVKDSISEAHTNPEATTNQEALADKYATEKELQQKFPIEESAGRFVQPVEEVPQVVKDSMAEGYKDPEAAANLKAVDEKSATEKELQEKFPVEDSAGRQIDGHYPVPRAVKDSIAEAHKDPEATTNQEALGEKYATEKELQQKYPVEESAGRYNKPVDEVPQVVKDSMAEAFRDPEAAANQEAVDEKYATEKELHKKIRVEESAGAPAPTVTAATQAIAPHVTASGVDSSDVSPLSTPTANRSFTAATPSSALKTTESSGPTVTTGPETTSTAETSTAGTTAAATADPAGPTVTTGVASAQAPTSSTAEPADPAATTGAGSTQSPATSSKPASPSRRKSHSTEGAASTIGDKKKKHRLSGFFDKIKEKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W6PZ41</accession>
    <name>W6PZ41_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PROQFM164_S01g001033</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PZ41"/>
    <dbReference type="STRING" id="1365484.W6PZ41"/>
    <dbReference type="OMA" id="ILFQFPV"/>
    <dbReference type="OrthoDB" id="1932925at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000425">
        <property type="entry name" value="MFS transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000540">
        <property type="entry name" value="MFS transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF55">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G01820)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="128"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="221"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="289"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="325"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="354"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="384"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="416"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="448"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM27224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="507" mass="56135" checksum="8065863C308AB448" modified="2014-04-16" version="1">MIQVHGITSAGESPHVSSEKDAALAVVSEFAQEIDPVVEKRVLRKIDLYLMPAMLIGYGMVYYDKAILGSATLFGMTTDLGLLVKDYSTSPPSADTSRLSWATSIFYFGMLAGLYPMTFILQRFNTRIVLGPVVLTWAIVCAATAGVTTWQGLFVQRFFLGFIESVIPTGFMTIVSGWYTQEEQALRQAWWFSGTGWFTIIGGAMNYGFGQITAGSLKRWQYIYILAGALTFLFGLWCCTMPNSPVSAWFLTLEERRVAVERLRKGQTGVRCQKIKFDQIKESMMDIKIYLVAIMMAAAYTINGAISGFGPLIVSTFGYDTLHSILFQFPVGGICVIFIPLCGYIPTVVPNTRIPLLIVCCLPVIAGCVMIWKSQWGYHPVTPVVGYALTGFFGPVVSLVITIGASNVAGATKKTVMAATVFVAYTVGNIIGPQLVKSKTKSQHYPELWTGMIICYCITIAAAVVLYFVLRRENQIRESLELDEVQRDKIAFDDLTDKQNPFFRYAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>W6PZH2</accession>
    <name>W6PZH2_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="6">PPIase</shortName>
            <ecNumber evidence="6">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">cyp1</name>
        <name evidence="8" type="ORF">PROQFM164_S01g001143</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 6">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the cyclophilin-type PPIase family. PPIL1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="6"/>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PZH2"/>
    <dbReference type="STRING" id="1365484.W6PZH2"/>
    <dbReference type="OMA" id="ELYNDHA"/>
    <dbReference type="OrthoDB" id="271386at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000008">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024936">
        <property type="entry name" value="Cyclophilin-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625:SF4">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE DOMAIN AND WD REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001467">
        <property type="entry name" value="Peptidylpro_ismrse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="7">
        <location>
            <begin position="1"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM27334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="162" mass="17747" checksum="00026975B5C75522" modified="2014-04-16" version="1">MTTEVAFDTSMGSFSVELYNTHAPKTCKNFATLAERGYYNNVIFHRIIPDFMVQTGDPTGTGRGGSSIYGEKFEDEIRGELKHTGAGILSMANSGPNTNGSQFFITLAPTPWLDGNHTIFGRVKNGMRVIQRMGLVKTGAEDKPVDELKIIRARVVEAGTQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W6PZH4</accession>
    <name>W6PZH4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="4">F-box domain, cyclin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S01g002938</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PZH4"/>
    <dbReference type="STRING" id="1365484.W6PZH4"/>
    <dbReference type="OMA" id="MRDLWMR"/>
    <dbReference type="OrthoDB" id="629492at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22904:SF523">
        <property type="entry name" value="STRESS-INDUCED-PHOSPHOPROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22904">
        <property type="entry name" value="TPR REPEAT CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="F-box" evidence="3">
        <location>
            <begin position="149"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM29126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="582" mass="65265" checksum="3D3D5EFD5506BBF7" modified="2014-04-16" version="1">MASRSGTRMVRGVISKKKPDIEQAAALQRAGQNAYKVGDLQGAIESFTQAWVANNEDTSILDNRAATYCKLKQYSQARADARAMVKLAPNDDRGYLRLAKILCLDGNFDKARDIYEYALQKLPTDHPGRKAIEQLLRRLQDKLAGGNRRDPFMVLPLEIAELTLQRLPFKQIVAMLRVCKGWNRFLSGLASLWMHLDLTGARLRVPWTSVRNYIHRSRAQLTNATITNIPPSTMTKVLDMLSRCPQLEHLEVAVPHDQPKQFYSKIQDFRHLKSIVCGADIRLSHASVGGILSTLSKLERAAFLHVWDHSNRGPQTWPQHLPNMKSLTIASSQENNQFLSFRDVLPGLGLSVYPNLEELRLVWDPARSQSYRFDPVKEEEQLPPLRILDLRGAAVQHNFYSILPTSLETLRLFSGSIEASHLGGNLLTPGENELPNLKTLVFNDTPWVNRSTLSLFLLHSKAPLRTLHVNLCHNIKSEELLNVLNDSNGANPELKELTDVGVACMAGMDDTSVKSLWVTLPNLKILDLSQTRITGCTIRMFADTWTEGPATAKLEGLIIKGCDDVSRDAIDYGRQMGLKIVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W6PZV4</accession>
    <name>W6PZV4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein kinase-like domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g003601</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PZV4"/>
    <dbReference type="STRING" id="1365484.W6PZV4"/>
    <dbReference type="OMA" id="LQEARIC"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="59"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM29788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="249" mass="28327" checksum="834BC003C57B0138" modified="2014-04-16" version="1">MHYRDMAEIWELGGSPKLRYTNVIFQDGDKYFAAQLPGKFAHPDEILPEAESCLKEIPAEHIWPLLEDGLSICHDADNPDVYIKQPQLLDYDGSEFLSVLLLQEARICQVLMQNEHRNIARYLGCVVKGGRITGLCFQRYVETLAGCLEAGRSVDNKSCLQQIKAGLDHLHALNLIHNDIHMRNIMIASQEAVIIDFDSCIIKGHQLPAKHKRGRIPEDVWTAGFENDHLGFKIFQDKLLSGDIYYLRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q0F7</accession>
    <name>W6Q0F7_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 17">Delta-aminolevulinic acid dehydratase</fullName>
            <ecNumber evidence="5 17">4.2.1.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">PROQFM164_S02g000167</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 17">
            <text>2 5-aminolevulinate = porphobilinogen + 2 H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24064"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58126"/>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <dbReference type="EC" id="4.2.1.24"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 17">Homooctamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 18">Belongs to the ALAD family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.24" evidence="5 17"/>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q0F7"/>
    <dbReference type="STRING" id="1365484.W6Q0F7"/>
    <dbReference type="OMA" id="YQMDYAN"/>
    <dbReference type="OrthoDB" id="1530at2759"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00318"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004655">
        <property type="term" value="F:porphobilinogen synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04824">
        <property type="entry name" value="eu_ALAD_PBGS_cysteine_rich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000048">
        <property type="entry name" value="Delta-aminolevulinic acid dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001731">
        <property type="entry name" value="ALAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030656">
        <property type="entry name" value="ALAD_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006762">
        <property type="entry name" value="PRK09283.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11458">
        <property type="entry name" value="DELTA-AMINOLEVULINIC ACID DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11458:SF0">
        <property type="entry name" value="DELTA-AMINOLEVULINIC ACID DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00490">
        <property type="entry name" value="ALAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001415">
        <property type="entry name" value="Porphbilin_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00144">
        <property type="entry name" value="DALDHYDRTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01004">
        <property type="entry name" value="ALAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00169">
        <property type="entry name" value="D_ALA_DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="10 17" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 17" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 16" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="14">
        <location>
            <position position="249"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="14">
        <location>
            <position position="302"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>5-aminolevulinate</name>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="271"/>
        </location>
        <ligand>
            <name>5-aminolevulinate</name>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="329"/>
        </location>
        <ligand>
            <name>5-aminolevulinate</name>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="368"/>
        </location>
        <ligand>
            <name>5-aminolevulinate</name>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00020771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001415-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR001415-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR001415-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU004161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CDM30018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="377" mass="40856" checksum="2A19CB01AD8009AF" modified="2014-04-16" version="1">MSFSNLVSDIAFRDARVDDGSSQISHARSQMSRATARSYASTAATSISISGEVSSQLHAGYSHPLTRAWQADRQLTKDMLIYPLFVTDNPDEETSIPSLPNQHRRGINRLVPFLAPLVRKGLRSIMLFGVPLHPSAKDALGTAADDPDGPVIKAIRLLRSRFPQLYITADVCLCEYTSHGHCGILREDGTLDNGQSVDRISDVAVAYAAAGAHCVAPSDMNDGRIRAIKLKLIEAGLAHRVLLMSYSAKFSGCLYGPFRDAAGSCPSFGDRRCYQLPPGGRGLARRAIQRDMAEGADIIMVKPASSYLDIIRDAKDLAHDLPVAAYQVSGEFAMIHAAAKAGVFNLKDMAFESTEGILRAGAGIVITYFVPEFLDWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q0J1</accession>
    <name>W6Q0J1_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Foie gras liver health family 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S02g000207</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q0J1"/>
    <dbReference type="STRING" id="1365484.W6Q0J1"/>
    <dbReference type="OMA" id="CVEYYRD"/>
    <dbReference type="OrthoDB" id="6278596at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012880">
        <property type="entry name" value="Gryzun"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021773">
        <property type="entry name" value="TPC11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14374">
        <property type="entry name" value="FOIE GRAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14374:SF0">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11817">
        <property type="entry name" value="Foie-gras_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07919">
        <property type="entry name" value="Gryzun"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Trafficking protein particle complex subunit 11" evidence="3">
        <location>
            <begin position="360"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="domain" description="Gryzun putative trafficking through Golgi" evidence="2">
        <location>
            <begin position="665"/>
            <end position="1258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="907"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="300"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM30058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="1261" mass="140890" checksum="533891FDEDF67EE0" modified="2014-04-16" version="1">MDAYPEDYVNHNLPLVLLSGLEAGPENDTKTSLSYPLLSEKGTHIFSDFPHLSGAVAEELRSLLLLEDSSQMPWKSRVTVSGNTTTANIGYRIKSSGRSCRLPPRKADPPVPSPPTTPSDDQDNEHPEPSSHYVLHSPISPLSPGSPTFPDGLLTPLWVTKHQELVPAAVINFFPFSLDPNMNSLRDNQLKIEINSLKKEWQSSGYKTRFVVVLISEDGEEGGYEGEIDDRIAGIRRSTNLEPRSIFVIPPDASSSELQDFVKSLFSLLQPSVVEYYRDLSKHARRKRNRGSIPPPTAPPTTGTSQTLSSQGWNVRYEFKLGIFAEFRQEMDAACRNYESAYDTLFGHEVFENIAGWNPRFNDARLLADALAIRIIRCLLWTGQTTAAARLWVDHRIRVKDIVNRRGKGSKNYGWEAWEARWSMVMAQLIRRAEIPSISSEISSEQPGDIYTLPEKSIPTGERVRPWENLHHEGYWLHRSAKHTMIRRALARKIPLEDRKPPGQSPGSQLANKSYLYDTYLVPGPYAEAPQEGRTGFDHSGLILNTLKAAIEEFAKRHQTRKVESLSLEAAEEYMRIGSWSEAHGLLRPLWSTLSWRRSGWWHLMVNFGWALRESALRVQDSETVLRVDWELLNKTFKPRPAWHYDIHRSLEGLPLEKPKPSLILRAEDVITSLTASLVFEKSNGNVGEPLQAQLAITSCAHKSSAPIRLSEVKLVFEGCLRPVKVQSDQDQHADTTTPCCIATLPLREPSNPDTAIQSPAGGLTALVGIADLTLGPSQTKVFNLTCIPREAGEAKVASITMLIEEEQFDLGYAITEPGQRESSWWQQTQKGVTRRRVGKDRDTGRCKVMPKPPKIRLTTPNLKATYYTNERVMLQIGIHNEEDEAADVSAEIRLFGTESTAEIQWLDDDSSSEPPDSGASTPTEGPSHYLKRAVGVLERSSNKTLTIVLADTQEATDFTLEVSAVYHLVSDIQTPIMKNITVALSFIRPFEANYEFLPAIHPQPWPNFFAVSDNLLEDGSAPSPGGLFQKWCLNSKVVSFALEPLVIDKMSLRLLEANGGAICEVHSEELVTPETSHIAPEELRESNFCLDIQKLLLGDRRPTALTCALEVNWRRRSSESASSDDAENSVTTTVLDIPRFVVPMGEPRVLASATPSSNMAGLIHLNYVLENPSTHFLTFNLVMEASEQFAFSGPKSTVVQLVPLSRHTVVFNLFAAKRGLWIRPQLVVIDTYFNKTLRVLPTGDMRSDKKGVLVWADADD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q0M1</accession>
    <name>W6Q0M1_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Azaphilone pigments biosynthesis cluster protein L N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g003323</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q0M1"/>
    <dbReference type="OMA" id="ILCKDAC"/>
    <dbReference type="OrthoDB" id="432483at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031348">
        <property type="entry name" value="PigL_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17111">
        <property type="entry name" value="PigL_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Azaphilone pigments biosynthesis cluster protein L N-terminal" evidence="1">
        <location>
            <begin position="3"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM29511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="291" mass="32155" checksum="03A141B22EB5AC14" modified="2014-04-16" version="1">MATLGIVTGGIGIASATTHSIHKLIQTIDAIKSAPTEITNLKNELLATEQVLSGLEDANQSSQLELLPFNSRQTLQRTNILCKDACDKFKDKLESWTKRSDDGVSMRDRFGFGILRQKSVKSLCEKLERCKSNVNMAVGFATITTLALRSTTNAMQNDFQARENEISQQIVEIEQQNAVVQMDLDDSTEVSLPNDQEHTLLVDQLNYQRATLEASQEFMKDLLTQASQVRRGQRITDVEMSGKGKALVGRVGFENDEGDLYQEIHNVKATTGGKGIVGVVKGLDINAFFKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q0M3</accession>
    <name>W6Q0M3_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Pentatricopeptide repeat</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PROQFM164_S02g000247</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Regulates mitochondrial small subunit maturation by controlling 15S rRNA 5'-end processing. Localizes to the 5' precursor of the 15S rRNA in a position that is subsequently occupied by mS47 in the mature yeast mtSSU. Uses structure and sequence-specific RNA recognition, binding to a single-stranded region of the precursor and specifically recognizing bases -6 to -1. The exchange of Ccm1 for mS47 is coupled to the irreversible removal of precursor rRNA that is accompanied by conformational changes of the mitoribosomal proteins uS5m and mS26. These conformational changes signal completion of 5'-end rRNA processing through protection of the mature 5'-end of the 15S rRNA and stabilization of mS47. The removal of the 5' precursor together with the dissociation of Ccm1 may be catalyzed by the 5'-3' exoribonuclease Pet127. Involved in the specific removal of group I introns in mitochondrial encoded transcripts.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Binds to mitochondrial small subunit 15S rRNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCM1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q0M3"/>
    <dbReference type="STRING" id="1365484.W6Q0M3"/>
    <dbReference type="OMA" id="TDHVYNE"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47447">
        <property type="entry name" value="OS03G0856100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47447:SF17">
        <property type="entry name" value="OS12G0638900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="5">
        <location>
            <begin position="694"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="50"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="64"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="96"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00044493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM30098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="799" mass="91661" checksum="6B2145D6AD227EC2" modified="2014-04-16" version="1">MSSCPHQLVRSRLNGLLSPQCRTLGRWYRESGTNVGHRVRLSTYNAPAIFEPGVTHDAPDPISYQHNRGSTDSSHSPTSEQSDQVATNQYGIGHGQSKPSTQPRSSSQTPIITNDKMKKVAYVRKADPKLVAMAAERVNREILNKGRHLTDRGLYLALSMRMNSLYMRELGLRQWKEAYGAIHKAKTHGREVLHNSALPKLREDGEQLLALLLEDCQGKFREAWLAMTRPNRAWAWQRLAIWLLQNNPAMALEFLLVTTEPRDKPDLTMVVDCLTYLERFHYEELRDWTKGAHTFESVVATSLDPKDWPIISPPQRGIRFYIRRAGFLGGYESFRLMNERGITMEAQTALCYMYRFTQLNDVEYALRALEFIPKINDPEFSMDSEGVLRHCCKLLTLDTVEDNASGRNFRILPRLLKMGVQPDRDMMNLVLANAYKTGDPQLGSDMLQFMKNHHHEFDSYTYLTLLTDAVSRGDRGRVDELVREVEMQEELRNNPYIFSKIFHAHFTFTAKHIDPESDPSGVFYSMLDMYNKIHDITPLKELLLLPPSYSPPPSQGLELKTPPSPVSLFLMIATFFRCRNRISQVHHMYDRFRELVQQGHPSIAPLVETDHVYNEFLIAFRKSSRGLRSSIRLVEDMLDTSAIPKETITGKPLKHIAPTHRTWTILLSAFNYSRQPDAAEKVKEMMAKHNVEYNQVTWNTIINGFANAQAIPETASAITKMEREGFAIDHYTMKSLRYLRDPERLWVAIEEMDEGLNSDGTNKLLTLEPASNVHSDQKVHDELIDNGLEKLESKLKPKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q1B1</accession>
    <name>W6Q1B1_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Translation initiation factor RLI1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">ATP-binding cassette sub-family E member RLI1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">RLI1</name>
        <name evidence="10" type="ORF">PROQFM164_S02g000472</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the multifactor complex (MFC) involved in translation initiation. Required for the binding of MFC to the 40S ribosome. Required for the processing and nuclear export of the 60S and 40S ribosomal subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q1B1"/>
    <dbReference type="STRING" id="1365484.W6Q1B1"/>
    <dbReference type="OMA" id="MVCIQNG"/>
    <dbReference type="OrthoDB" id="6593433at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060255">
        <property type="term" value="P:regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03236">
        <property type="entry name" value="ABC_RNaseL_inhibitor_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000144">
        <property type="entry name" value="ATP-binding cassette sub-family E member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000152">
        <property type="entry name" value="ATP-binding cassette, sub-family E, member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013283">
        <property type="entry name" value="RLI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034348">
        <property type="entry name" value="RLI_dom_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007209">
        <property type="entry name" value="RNaseL-inhib-like_metal-bd_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009945">
        <property type="entry name" value="PRK13409.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19248">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00037">
        <property type="entry name" value="Fer4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04068">
        <property type="entry name" value="Fer4_RLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01868">
        <property type="entry name" value="ABCEFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54862">
        <property type="entry name" value="4Fe-4S ferredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="9">
        <location>
            <begin position="46"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="70"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="344"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="600"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="649"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="666"/>
            <end position="684"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00056499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00067238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00082546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDM30323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="684" mass="77109" checksum="36110BC0132BF795" modified="2014-04-16" version="1">MSDKLTRIAIINSDKCKPKKCRQECKKACPVVRTGKLCIEVDPTSKIAFISERLCIGCGICPKKCPFGAIHIINLPTNLETQVTHRYSANSFKLHRLPMPRPGQVLGLVGTNGIGKSTALKILSGKLKPNLGRYDNPPDWEEILKYFRGSDLQNYFTKILEDNLKAVVKPQYVDQIPRAVKGPIQQVQQLISGRAALGNEEEIMDVLELRQVAHRDIGHLSGGELQRFAIGLVCVQKADVYMFDEPSSYLDVKQRLAAARTIRSLLRPDDYVIVVEHDLSVLDYLSDFICVLYGRPAVYGVVTLPSSVREGINIFLDGHIPTENLRFREESLTFRLTEAGEEFIADKDRAFSYPSMEKTLGDFHLKIDAGKFTDSEIVVMMGENGTGKTTFCKMLAGALKPDGAITIPKMNISMKPQKITPKFTGTVRQLFFKRIKTAFLSPQFQTDVYKPLKMDDFIDQEVQNLSGGELQRVAIVLALGMPADIYLIDEPSAYLDSEQRIVAARVIKRFIMHTKKTAFIVEHDFIMATYLADRVIVFDGQPSVDARAQTPESLVGGCNRFLKSLDVTFRRDPISYRPRINKYNSQMDQEQKLAGNYKRIEKGVHNEHRRRRHKHDGRDYEQRRNRRRGDWKIMWLMGIPGVCRASAVQGKGYRRRAGPSSGADDGLSDDDGDDDDLNGNSDPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q1Q0</accession>
    <name>W6Q1Q0_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S02g000040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM29891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q1Q0"/>
    <dbReference type="OrthoDB" id="10269240at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM29891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="95" mass="10879" checksum="BA575D0C0FF59B0E" modified="2014-04-16" version="1">MTIPVPSPLRQFVAAPHWPSPTTVAVCTPIGTYRRQYMTGAMTARTETTRDPVARAQSVPPCWDEVIIQEIYEEWGVPDPQRLRGLFKSRRIRQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q273</accession>
    <name>W6Q273_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CsbD-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g002090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q273"/>
    <dbReference type="STRING" id="1365484.W6Q273"/>
    <dbReference type="OrthoDB" id="5309565at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036629">
        <property type="entry name" value="YjbJ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40460">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40460:SF1">
        <property type="entry name" value="CSBD-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69047">
        <property type="entry name" value="Hypothetical protein YjbJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM28279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="148" mass="15773" checksum="58412B3447354AB6" modified="2014-04-16" version="1">MTNNTGNASTNESYLEQASDLASRAIGTVTGTNTSTQTDEHKHEAKRDDGSWDQTIGSAKESVGNLIGNQTLRRTGAEQNAAGKEQEAKSQLQNWGEGIENRAQGAIGSIGAAVTGNRSEEDKYRDLHDEGKAHQLSAEADMIKKNAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q2J1</accession>
    <name>W6Q2J1_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="7">GPR1/FUN34/yaaH</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PROQFM164_S02g000355</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q2J1"/>
    <dbReference type="STRING" id="1365484.W6Q2J1"/>
    <dbReference type="OMA" id="IPIWHIF"/>
    <dbReference type="OrthoDB" id="3648309at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015123">
        <property type="term" value="F:acetate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051633">
        <property type="entry name" value="AceTr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000791">
        <property type="entry name" value="Gpr1/Fun34/SatP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31123">
        <property type="entry name" value="ACCUMULATION OF DYADS PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31123:SF6">
        <property type="entry name" value="MEMBRANE AMMONIUM TRANSPORTER (ATO3), PUTATIVE (AFU_ORTHOLOGUE AFUA_5G01140)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01184">
        <property type="entry name" value="Gpr1_Fun34_YaaH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="89"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="119"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="165"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="190"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="224"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM30206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="277" mass="30113" checksum="9C3DFD07F1B4E987" modified="2014-04-16" version="1">MSDDTIGDKPETSTAEMLRRYQTTDSVMLPIPRDVFEKLYLSPKTPNAGKLRSTFGNPTPISLMGFLLSATPTAMLTMGWRGAGGNGGAILPVYIFFGAMVQIFGAIGEWILGNTFSCALFFTYGTFWLVQGTSLMPFFAVGTMYSSDGNTLKGMETAEYSATVGFYYVTLALITFVYTICALRTNVCLFLALFLLVITFGLFSGIYFQMALGNLVLAAKLQKAAGAFTFALCLPIWHIFIAQILEAVDFPIALPVGDLSTVILGRSQKARKCEVEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q2Q0</accession>
    <name>W6Q2Q0_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type DNA-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PROQFM164_S02g000755</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q2Q0"/>
    <dbReference type="STRING" id="1365484.W6Q2Q0"/>
    <dbReference type="OMA" id="CITERAY"/>
    <dbReference type="OrthoDB" id="4132249at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050797">
        <property type="entry name" value="Carb_Metab_Trans_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668:SF19">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="14"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="48"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="56"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM30605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="562" mass="62036" checksum="B043A408D7FD684A" modified="2014-04-16" version="1">MSASIRPTQQRTPACDNCRRRKVRCNREQPCGKCQEVFLNCQYTSVPRRKGPKGPTAPVLSSLSSSSNHSSPHTSSVSFAASDAGHADAVGPPSESNLEDQWTFLPTTECPDTRFVGLLKSPTFPTAACQRISPVLLQAHVDIFLKHLYPIMPVFDADTVTVECMSPEALSPRRYAFIVALCAATHLQLKLDISEGGTIEELSLSGQSLIEQAIQALQEFDPLDEPHTDTLLAFFFLFSAYGNLDKHNHAWHYLSQSISFAHLLNLHQEPSYLAQDPETAELRRRIYWLLFITERAYALQRNMPITLRGRIQKPTVFTSNSPALAYGFVNLISVFEKIPSSFYDWNASAAGSLGDSAMINPIYQSVALSTPLLAEYNETQKVDLIVTRQWLQTRLWKVVSDQVDSTCHQGAVVPLDLPITAGKSVMALMSTVAQKSADAHGIGIEQKLYDIGETVSLLAHVLLPRKNDGVGELFAHAQTVLCGIIDLLSNIRGGQSYLFSSLLQQSHAILGLEALPPHLAFPSYWNPTLADNDGSLPGPDDCMSLQRYKTFKDNCFDPKLST</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q2Z6</accession>
    <name>W6Q2Z6_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4396 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S01g002390</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q2Z6"/>
    <dbReference type="STRING" id="1365484.W6Q2Z6"/>
    <dbReference type="OMA" id="MWFLQAY"/>
    <dbReference type="OrthoDB" id="2128064at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025509">
        <property type="entry name" value="DUF4396"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14342">
        <property type="entry name" value="DUF4396"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4396" evidence="2">
        <location>
            <begin position="75"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM28579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="214" mass="23626" checksum="107707F581A3BE26" modified="2014-04-16" version="1">MRHSFLLHRGRGLCWASRRAFSGATHAQACHTEKKQCSKSIEREQKLSQAPKCAKTPPLQPLPTLSLPFWTCRSTWKRAGINTLRCLVGCTTGDFSSLWILQTYYPEMGMSSAMALSMACGITTSVILETILLRRGADQLSWPMAARTAMGMSMVSMLAMELAENAVDYHLTGGVVALGDPNFWLAAMLSIGAGYLAPLPYNYLRLRKYGKSCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2024-10-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q313</accession>
    <name>W6Q313_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S01g002405</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q313"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM28594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="69" mass="7458" checksum="C8CA2C430D6CCCDF" modified="2014-04-16" version="1">MIYAICNIGSRTAGNLFLCEVVSSLSSQSLCIHLSIWTSLPICLAETGHVPCFYVSIIQLADQTALLVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q3B9</accession>
    <name>W6Q3B9_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ethanolamine kinase</fullName>
            <ecNumber evidence="3">2.7.1.82</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S02g000615</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from ethanolamine: step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the choline/ethanolamine kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.82" evidence="3"/>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q3B9"/>
    <dbReference type="STRING" id="1365484.W6Q3B9"/>
    <dbReference type="OMA" id="FALIPKY"/>
    <dbReference type="OrthoDB" id="10267235at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004305">
        <property type="term" value="F:ethanolamine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05157">
        <property type="entry name" value="ETNK_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22603">
        <property type="entry name" value="CHOLINE/ETHANOALAMINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22603:SF66">
        <property type="entry name" value="ETHANOLAMINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01633">
        <property type="entry name" value="Choline_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00037883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM30466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="412" mass="46448" checksum="2DAE5E3493E6F24F" modified="2014-04-16" version="1">MGSTYTQAPTPEFRYIPLSYSHEDSQASALRLILTLNPDWEGPDNNIEFVRFTDGITNTLLKIINLKPGLTEEQIDNEAVLMRAYGNGTEILIDRERETKSHALLANRGLAPPLLARFKNGLLYRFIRGRPCNHQDLVSPPIWRGVARRLAQWHAVLPSSAAVPDKDAPVAEIANSQDDEITVIKPRRAGPSMWAVLQKWVLALPVTTPEQRARRLSLQAELQWVLDMLDDGKGIGEDGLVFSHCDLLCANVIVLPSENGVPTPEDGVAPVNFIDYEYAVPAPAAFDISNHLAEWGGYDCDYNMMPTKSVRRQFLTEYTQSYCEQRGLDASSQAEIVDRLYEDVDRFRGIPGLYWGVWALIQAQISQIDFDYASYAETRLGEYYAWKREVDGSRKQAGEEMPLRESRWASEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q3F8</accession>
    <name>W6Q3F8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type DNA-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PROQFM164_S02g001288</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q3F8"/>
    <dbReference type="STRING" id="1365484.W6Q3F8"/>
    <dbReference type="OMA" id="CHACIIR"/>
    <dbReference type="OrthoDB" id="4159781at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="13"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="74"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="358"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="74"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="134"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="161"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="379"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM31138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="451" mass="48479" checksum="066A796514AF818D" modified="2014-04-16" version="1">MPDSKTKIRPQQSCLRCRERKVKCDRSVPCHACIIRGLEAECTYLTTAEDRAHISQSEIINQLRREVSQLRERLNRGSREPGDTQSQHERPGQGAGPHAPAHNYDNHGHGHGHGNGAGSASAGGTPDTGEGSWRGSSPASSIITNSMTVTSPDSTGSENGTRSTSASSRSTSTSAYPIATGYPPQIAELDGPTVQPLACRNTVEDTTMFDCYTGGVTYPPGAMTGTVSVPMQGLPVHALHAQDAMLGMHYPSIYGVNSDNYMLDGEALPYLQHTGYPAPILTSTVPHYGEEYSIRNEYDRPHAFHHWGQDAYGNPNPSPNQFPQTHIYQTPSHYSTIPFTNITANTNINTYAAAPFSPPAPTHLADDTLSHAGPDSQDRPSPTTIMNSMPSSWKGEGKQELLEILLETIGSCDEQRLPQVIQVLRTSPSPEEAVSGVCQVLGIGTGRLAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q3N0</accession>
    <name>W6Q3N0_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Rhomboid-type serine protease</fullName>
            <ecNumber evidence="10">3.4.21.105</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PROQFM164_S02g001363</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Serine protease involved in intramembrane proteolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Cleaves type-1 transmembrane domains using a catalytic dyad composed of serine and histidine that are contributed by different transmembrane domains.</text>
            <dbReference type="EC" id="3.4.21.105"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Membrane</location>
            <topology evidence="2 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the peptidase S54 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.105" evidence="10"/>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q3N0"/>
    <dbReference type="STRING" id="1365484.W6Q3N0"/>
    <dbReference type="OMA" id="PIMIKPQ"/>
    <dbReference type="OrthoDB" id="2146116at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002610">
        <property type="entry name" value="Peptidase_S54_rhomboid-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22936:SF69">
        <property type="entry name" value="RHOMBOID-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22936">
        <property type="entry name" value="RHOMBOID-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 10" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0720">Serine protease</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="247"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="288"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="317"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="340"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="365"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="454"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S54 rhomboid" evidence="12">
        <location>
            <begin position="245"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="43"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="56"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDM31213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="514" mass="56531" checksum="915680419CF36497" modified="2014-04-16" version="1">MASNEYYHANIPQPPSYDQAVPGKTDNAPHTAPGLGYATPVYNHDDPSAPYHNRESQQSFASDNGHYQTAGRATEGDNYAENIPLKTNAQYGNNPDWMRQQTQYPPSPGGLEDSRQRDGRKKKGFFSKKIAWVTYILTLAQIIVFIIELVKNAQLTGSVIETKPTFNPMIGPSPYVQIYMGARYNPCMKNVEGIQDANYTLSWLCPNATSTTVTGTGCTLSEVCGFSGVPNPSIGGSTDDRPAPNQWYRFIIPIFMHGGFIHIGFNLLVQMTMGADMERMVGMWRYTLTYFASGIFGFVLGGNYAAQLDPSDGCSGALFGILALYLLDLLYDWPQRESPWVELIIMLLGVGVSFVLGLLPGLDNFSHIGGFIMGLAIGLTIMRSPNALRERIGLARQPYVAMSGGAGQAGPEQKTIPFMEFFKSKRGLTSHSSENPGPTGGPLGFFKGRKALWWLWWLVRAGALVAVLIGFIMLLIDFYKYPSSNCSWCYRLSCLPVNGWCTQNNLPTSNATSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q452</accession>
    <name>W6Q452_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein uL11m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">MRPL19</name>
        <name evidence="11" type="ORF">PROQFM164_S02g000886</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the universal ribosomal protein uL11 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q452"/>
    <dbReference type="STRING" id="1365484.W6Q452"/>
    <dbReference type="OMA" id="CKQFNAK"/>
    <dbReference type="OrthoDB" id="1091498at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00349">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.250:FF:000005">
        <property type="entry name" value="Mitochondrial 54S ribosomal protein YmL19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1550.10:FF:000004">
        <property type="entry name" value="Mitochondrial 54S ribosomal protein YmL19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.250">
        <property type="entry name" value="Ribosomal protein L11, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1550.10">
        <property type="entry name" value="Ribosomal protein L11/L12, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00736">
        <property type="entry name" value="Ribosomal_uL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000911">
        <property type="entry name" value="Ribosomal_uL11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006519">
        <property type="entry name" value="Ribosomal_uL11_bac-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020783">
        <property type="entry name" value="Ribosomal_uL11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036769">
        <property type="entry name" value="Ribosomal_uL11_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020784">
        <property type="entry name" value="Ribosomal_uL11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036796">
        <property type="entry name" value="Ribosomal_uL11_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01632">
        <property type="entry name" value="L11_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11661">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11661:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL11M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00298">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03946">
        <property type="entry name" value="Ribosomal_L11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00649">
        <property type="entry name" value="RL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54747">
        <property type="entry name" value="Ribosomal L11/L12e N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46906">
        <property type="entry name" value="Ribosomal protein L11, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 8 11" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL11 N-terminal" evidence="10">
        <location>
            <begin position="12"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL11 C-terminal" evidence="9">
        <location>
            <begin position="75"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDM30736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="153" mass="16512" checksum="18CE814208534B46" modified="2014-04-16" version="1">MARNVLSKDQFVKLIVGAGQASPSPPVGPALGSKGVKSMDFCKEFNARTAHINTGVPIPARVTVRPDRSFSFELRTPTTTYLLLNAANVEPRKNRLRGAMNPGHDVCGKISLKHVYEIAKLKQTETRLSGLSLEGLCKSVMSQAKSIGIQVVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q461</accession>
    <name>W6Q461_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Elongated TPR repeat-containing domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S02g001548</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q461"/>
    <dbReference type="STRING" id="1365484.W6Q461"/>
    <dbReference type="OMA" id="KSAIDDC"/>
    <dbReference type="OrthoDB" id="1872379at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052769">
        <property type="entry name" value="TPR_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46014">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46014:SF1">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM31398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="282" mass="31258" checksum="B080F30EAC09C040" modified="2014-04-16" version="1">MSSSSNAPERDGKGAPDDADDSGDEDVFHDAHFPAEEEAQLLKEAHEIKSEANQLFIATSYDQAISCYDRALASCPNYLDYDVAIIHSNIAACHLKLEDWKAAVDSATISIERLSKIIPPTPPDEGNESKGKQIPESEKKHTDAVVELSGDDEEAELKELQRLQEQDEQRGKVMRLRAKVLMRRAKAKTQIGGWGSLQGAAEDYQAVSAIENLSADDKRFVQRALRELPERINQAREKEMGDMMGKLKDLGNGILSPFGLSTDNFKFVQDPKTGGYNMNFQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q4H5</accession>
    <name>W6Q4H5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PROQFM164_S02g000996</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q4H5"/>
    <dbReference type="OMA" id="FFGAWQF"/>
    <dbReference type="OrthoDB" id="2130629at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718:SF41">
        <property type="entry name" value="MFS TRANSPORTER OF UNKOWN SPECIFICITY (AFU_ORTHOLOGUE AFUA_5G09940)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="131"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="173"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="228"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="265"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="293"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="333"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="363"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="402"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="435"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="466"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="491"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="571"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="137"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="92"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="13"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM30846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="602" mass="64373" checksum="8B9C59414E5DBDB3" modified="2014-04-16" version="1">MSNEPHAGADPQASGSQDLNITPPQGQDGGDSAPASSRSSMSYTRTYSTPATGAQTPDPLMGHKIVDKIALQDLSINDLNREIESYALDTTGNMKNRKLPDSVSRPHPGTDEESGSPIRSKQGIPPELSSFTAELVLIFVCSVGLMLFSFLLGDVLAPQEQIKAALGITNAELPWVIGAFNTANGLSVIISGSLTDLLPPKLLMVGAFAWLAIWNLIGAFSLQPSRCVLFFIVRAMQGLSIGVLVSGSMSILGRVYTPGIRKNRVFSAMAATAPLGFSLGAIQGGALSRHLPWIFGSNAILSVILCVAAWLAIPPLRPMADASGKEAPSIKQFDYIGGFCAAGGCVCLLFGLTQGPVASWSPYTYVLIIVSFGLFIGLFFAERNAVRPLIPNRLWRTPGFTPLMIAYFLGFGSFFGCWQFYAIQFWLRIQHASPIITALYNIPNALVGVLATLIVARTLHLVPGHYIYAVSMLAFTLGPAFFLPQTANTSYWALSFPGLILVTFGPDLAFAAASIFITSNVERSYQGSAGALLVTNQNLSSAILTSVADAIGTRVDKGPSGEIGLDGLRAIWWFGLAAQLLAALITIVWVRIPKEEEKEHVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q4K0</accession>
    <name>W6Q4K0_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AMP-dependent synthetase/ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S02g001718</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1365484.W6Q4K0"/>
    <dbReference type="OMA" id="LVWTYWT"/>
    <dbReference type="OrthoDB" id="69964at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010506">
        <property type="entry name" value="DMAP1-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056881">
        <property type="entry name" value="Mug62_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22754:SF32">
        <property type="entry name" value="DISCO-INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22754">
        <property type="entry name" value="DISCO-INTERACTING PROTEIN 2 DIP2 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23024">
        <property type="entry name" value="AMP-dom_DIP2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06464">
        <property type="entry name" value="DMAP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24919">
        <property type="entry name" value="Mug62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01137">
        <property type="entry name" value="DMAP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51912">
        <property type="entry name" value="DMAP1_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DMAP1-binding" evidence="2">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="273"/>
        </location>
    </feature>
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        <location>
            <begin position="693"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1691"/>
            <end position="1715"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1808"/>
            <end position="1908"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="693"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1695"/>
            <end position="1709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1835"/>
            <end position="1849"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1882"/>
            <end position="1892"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM31568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="1908" mass="211071" checksum="5FA5465D98F6B050" modified="2014-04-16" version="1">MAEESPEIQAALRDLDRELEEGDITQKGYQKRRTILLSQYFGPNKPLDINSQAGLGYDASPTSPGRVPPAILSVRPPTADSSLPHVTSPIYAGSHGSQGSGAVGYDQGAGINTQDQSHASLGSHRRESMLQAHDRAPSGSSYDSLFLPKPPAPGLQGQDGSRTATLMSQNYAFNPNSQPEYMSQPEYAQEYPQEYPQEYAQEYPQEYTPAEPEYADEGMAYYDPASGAPTRQSTMLDSQQGYFSDFAGQQHDDYRDSYGGGFHRYSQSGEAFSPTANMAPPLMPAGAELQHGPAIEHLLPLEPREIPFSLNDPHDKNVPMSNFDNLPAVLRHRARAHPKQAAYWVLDAKGKEVASITWEKLSSRAEKVAQVIRDKSNLYRGDRVALIYREAEIIEFAVALLGCFIAGVVAVPINSLDDYTSLNIVLTSTQAHLALTTENNLKNFQRDITAQKLSWPRGVEWWKTNEFGSFHPKKKDDTPALQVPDLAYIEFARAPTGDMRGVVMSHRTIMHQMACLSAIISTVPVESSARQYSTKGETIISYLDPRQGIGMIMAILFTVYGGHTTVWHEDRAVETPGLYAHLITKYKASVMATDYSGLKIATYNYQQDPMATRHFKKNSEPNFSSVKLCLIDTLTLDPEFHEILADRWLRPMRNPRAREIVAPMLCLPEHGGMVISMRDWLGGEERMGCSLTHEMDPAGRDDYKKEDESLTKSETKTGFGSSLLGGGSRVSTIKQSPKNELSEVLLDKEALKSNEVVVLAMGEDARKYASSMPHAVRVGAFGYPIPDATLAVVDPETNLLCTPNVIGEIWVDSPSLSGGFWALPKHTEAIFHARPYKFEEPNPTPILVEPEFLRTGLLGCVIEGRLFVLGLYEDRLRQKVEWVEHGQEIVEHRYFFVQHLTVSILKKVPKIHDCTAFDVFVNEEHLPVIILESYSASTAPTTSGGPPRQLDSVLLDSLADRCMEVLYQEHHLRVYCVLLTAPNSLPRVTKNGRQEIGNMLCRKDFECGMLQAVHVKFGVERSVMNLPVGVDPEGGIWSPTALASRQDLLAYQEKQYSGVDYRDVVMDDRTSTPLNNFNTIVDLLQWRVARQAEELAYCSIDSRGKEGKGVTWKKFDLKVSAVATYLKNKVKVRPGDHLVLMYTHSEEYVYAVHACLCLGAVVIPMAPIDQNRLSEDAPAFLHVIGDFNIKAIIVNNDVDHVMRQKLVSQHIKQSAQVLRIGVPAIYNTTKPSKQSHGCRELGYTVKDTWLQGNQPAMVWTYWTPDQRRISVQISHETIMGMCKVQKETCQMTSSRPVLGSVRSTLGLGFLHTCLMGIYVGAPTYLVSPVDFAQNPLTLFVTLARYKIKDTYATSQMLDYAMSAMAGKGFQLQELKNLMISAEGRPRTDLYGKVRLHFANASLDRTSINVIYSHVLNPMVTTRSYMCIEPIELWLDLRSLRQGLIYPVDPDADPTALLLQDSGMVPVNTQIAIMNPETCTLSHVGEYGEIWVQSDACAEGFYKSKQEFDSERLNGRVADGDPSVPYVRTGDLGFLHTVTRPIGPGGQPVDMQVLFLLGSIGETFEVNGLNHFPMDIENSVESCHRNIVNGGCAIFQAGGLVVVVVEVTRKAYLAALVPVIVDVILMEHQVVADIVAFVSHGDFPRSRLGEKQRGKVLASWVTRKLRTIAQFSIRDLEGDSPFADIPQHRMSRVSKAGSTMGTSIRQSTMNPDIDANVPRSLRGVTLEETSHPAATYQTGQAGSVPYELGSVTDNSPLATPIPGPSSAVPHIKEPQSATVVAEFDDQHYNTLDPTAGTSAVDRDFRFSFDMADNPDQSQSYGHPGDERPSTGREPLPSQQGWNPNSPQAASTPPAETARPSTQDSGVNDWPQEALMYQSALGAEDGHDVGRTDSDNSAPPNRQLRGLNLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q5J7</accession>
    <name>W6Q5J7_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S01g003301</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q5J7"/>
    <dbReference type="OMA" id="VNSGRIM"/>
    <dbReference type="OrthoDB" id="10404473at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM29489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="123" mass="13591" checksum="34EA35CF342B597B" modified="2014-04-16" version="1">MSTCGRVPSYLPIGTGLGRELAVGIRGGPIRGDHAIPLYRVMQLVNSGRIMYSDWLICQELAAQLYALGVARHLDPPSADETPRAPRQRAAPADVARHCDWLVADPESREFRIESLKARELEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q5Y4</accession>
    <name>W6Q5Y4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Pyridoxal phosphate-dependent enzyme, beta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PROQFM164_S01g003471</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ACC deaminase/D-cysteine desulfhydrase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q5Y4"/>
    <dbReference type="OMA" id="YVFVACG"/>
    <dbReference type="OrthoDB" id="10266364at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019148">
        <property type="term" value="F:D-cysteine desulfhydrase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027278">
        <property type="entry name" value="ACCD_DCysDesulf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43780">
        <property type="entry name" value="1-AMINOCYCLOPROPANE-1-CARBOXYLATE DEAMINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43780:SF2">
        <property type="entry name" value="1-AMINOCYCLOPROPANE-1-CARBOXYLATE DEAMINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006278">
        <property type="entry name" value="ACCD_DCysDesulf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="7">
        <location>
            <begin position="35"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="111"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="5">
        <location>
            <position position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR006278-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR006278-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM29659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="392" mass="42104" checksum="D89EA245E0AE287C" modified="2014-04-16" version="1">MSLPIQLPEAFAKIPRYNILYPTPSPIHPLSSIAPPRLSPHHPLITIHAKREDHSSPLACAGNKYRKLEYIVPDILSQTPLHHSHENNPTPPGPQQGGAATTLVTEGAIQSNHTVQVVALARKLGLKVVILLHRGTGGGLAAASDKEAFQHSGNVQINHLLGADVRVCEEGDPLAHDATPLLDELRASGQNPYWIPGGASLHPLGGLGYARAAFEIAAQEEEMGLGGSGRFDYIFVACGSGSTVGGLVAGFKLLDKIRGLDVSRKVVGILNSPTKPRAYHEKRVLNFARRAGELIGLDGERDIGIEDVRLDDRFVGTAYGVLDDKSKETLENMARMEGMVLDPVYTAKVARGMMHWVDEGEVVDSAKPLEQVNILFIHTGGQAALGAYVDVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q7Z8</accession>
    <name>W6Q7Z8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Beta-ketoacyl synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PROQFM164_S02g000518</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1365484.W6Q7Z8"/>
    <dbReference type="OMA" id="IMMDTAC"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901336">
        <property type="term" value="P:lactone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000019">
        <property type="entry name" value="Polyketide synthase type I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049552">
        <property type="entry name" value="PKS_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF29">
        <property type="entry name" value="ASPERFURANONE POLYKETIDE SYNTHASE AFOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21089">
        <property type="entry name" value="PKS_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="8">
        <location>
            <begin position="14"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="9">
        <location>
            <begin position="933"/>
            <end position="1241"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="7">
        <location>
            <begin position="2271"/>
            <end position="2349"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="6">
        <location>
            <begin position="933"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="6">
        <location>
            <begin position="1084"/>
            <end position="1241"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="6">
        <location>
            <position position="965"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="6">
        <location>
            <position position="1154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDM30369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="2356" mass="257209" checksum="E7018998D4186766" modified="2014-04-16" version="1">MPSLPATTSVPTDMEGIAVIGMGCRFSGGATSVENFWQMLCDGRTGHGTVPTSRYQASAWHHPSHERKGAINHDSGFFLQEDPSRFDAPFFSITAKEAAGMDPAQRLLLEVAYETFENSGIPIDTLPGSNTAVYSGSMTNDYELLSTRDIYDMPHNSATGNGRTMLANRLSWFFDLQGPSIMMDTACSSSLTAIHLAAQSLRSGECGMALVTGASLILHPNFTQRLSYMHMMSADGISHSFDESANGYGRGEGIGAVLLKPLSAALADGDNIRAVIRGTGINQDGRTPGITLPSPTSQANLIRSVYERHGISMRDTSYFEAHGTGTPVGDPIELSAVGMTLGQARTPTDEPIYVGSVKTNFGHTEGAAGVASLIKVVLCLEKGTLVPNAGFQNINPKIRLDDWRLRLSDKTMPWPDHLPQRASINSFGFGGSNAHLILESAKEALGNAKDQEPAPHVVVFSTFDQAGIERTGQNWSTFLQRQQKAEREASLKDLAHTMLTRRSQLGFRSFAVANSQDQLQSILDKGLPKFPRASRKAQTRLAFVFTGQGGQWAGMGRELLRIPTFRESIARSQEILSSLGCPFDMVEEIKAEAKDSQINRPDRSQPITCALQIALVDLLASWSVFPNAVVGHSSGEIAAGYAAGYLSREDAMRVAWFRGFFSQQIAQSDRRGGMLATGISAADAKKYLEELPARSVVVACVNSPASTTLSGDVEFIDQLEARLQQDGHFARKLRIDTAYHSPHMEDLVKVVGSAIDCIKPEDRYNGSIPMLSSVTKERVYPAELGGSYWVRNMVSSVEFTAAVSQLANLSESIKSRRRPVPIKWTALIEIGPHAVLKGPVTQILQSVNANMASLPYYSLVSRNQHALRTALEVAGSLWSTGHTIDLAAVNSSVDNTSPKMIPDLPSYPWNHQTSFWHEPLETAQLRQRQHPRHDILGAAVDFQNALEPRWRNFLRLSENPWMADHVVAGSIVFPAAGMLVMATEAARQLADSPANIKGIEFQDLHFMRGVVIPDEERGLETLLQVSPHPGMPGWYQFGIFSLPSGGAWIQHAKGAFIARFENRTDDEHNSNWQAALERIKNTQTVAKMADVGQAREWLSNTGGLTVGPAFQTVTGVSFCDSESRLWLSGVVTDTKQSMPFEKESSSFIHPTTLDCLFQSALLSCSDALSSNKANIPIGVDNIYISNTFQPQPGEQFVVHTETKWRDGKSQSHCIASDPTWSQPWITFEGVHLGRLPFNSNSLKQEEASSESRYSSIVWDEHLESPLVTSQINDGNKKKAVQASSLQLTDWIKRLCYTNGDARALITTSDTSSWIASLQELIPSAGKRPCLGRMTVASCGHENQVEGVTPTENSLPGTHLASLTTLSELPSSSLAQDKYDLVVIDEPKWDDKIIQVILSCLPTILEHGGLAAIRVSGTNRDSAAEKLQRLEGLEIHSTTKDREFIIARRTPVSWTTDSEIYILSPADKSNTLAVFEHLGNIFATHNVRLVPVELEQVGTLAGKTVISLLDLASPWISGWTENDLERLQELIRVKYVLWVSPSWSQGAVENIGSGATGGLLRTLRNEQWNTTIPHLLVDVEDLEDKFGLACGILQVMQLTTQESSRRPDLEYRLANGRLLVPRVIETPTVDEAMHTLMNGPRPVMSDLTLDPRRLELKFQDADNARWEEQQPFEEGLRTDHIEIMVEMATIFDLHGDQGKTPETALPMFEIVGKVTLIGSGVHDLAVGDKVLTLTSASSGLMTAMRVLESDTIRIPANMDPKNAISTPLAYINAYQILTQVGRLSSSSSVLLVGSISQTLQAMIDYALAMNMQVIVATDSADTTENLRSRYPVLADRILGVHGSLETSVSRLTNGCGVDASICFLGGYAGRNAARCLVPGGQYINLSSEMKMSALPESFIDSGCTFSSPRLQKIFSEKPGNLHASVRHVVDFMKQHRMLDRVESYSMFPVSDLQGALKHCKVANTRAIVDLRAPGRVPIVLPLPNLTGLPAEGTYILAGGLGNLGLALADTLVQSGARHLVFLGRSGGAQPGQQLALDLLRSHGCRIDVLRCDIAQQADIDHLSYKIRSKNWTVAGVIQCTTVLKDAMFENMTFDDWTQSTQSKIRGTLNLHHLFSEFEGLGFFIALSSVASVIGNMGQANYSAGNGFIDALMEWRRSHGLPGHSINIGLVPDASGLSDIAEDQEQRRRRYKHLEGTEIMTHELQTLLRVIINSKLSLPSQIIAGMTDHLSRSNGSIAWVLDRKFDHRLCLAADDTEDSIQTSALLKGCDSLDNATEVVLNALSEYLADAMATTADAIDSDLPLSALGVDSLKATAVQNWVSRELGSELSSFEFLGSQPTKALARKIASTSSFVSVPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q8T3</accession>
    <name>W6Q8T3_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S02g002926</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q8T3"/>
    <dbReference type="OMA" id="NSHRENV"/>
    <dbReference type="OrthoDB" id="2590867at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39606:SF1">
        <property type="entry name" value="CELL SURFACE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39606">
        <property type="entry name" value="SURFACE PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM32775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="130" mass="13912" checksum="690E7208498929DC" modified="2014-04-16" version="1">MSDQSSNGGPYRSKLANKLDPRVNSGSQNVPDAHLGYAHNYGKGGLHNNGIANMLDPRVSSDQDNSHRENVAASTPFMPQAGKPTGIRNRAADKPDQRVESDPDNHRRENVAGSSHFIPQAGKPTGNSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2024-10-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q911</accession>
    <name>W6Q911_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S02g002637</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q911"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004879651" evidence="1">
        <location>
            <begin position="28"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM32486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="76" mass="8452" checksum="FD2F2533CAF37B99" modified="2014-04-16" version="1">MFAFPCPLPFILPCILPFILPFTPATARTSTWCWGPVTLRGEAKTSLFNVLFPDCALRFVFSALQCCVCFAMKASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q9U6</accession>
    <name>W6Q9U6_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acetamidase regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">amdR</name>
        <name evidence="9" type="ORF">PROQFM164_S01g000366</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q9U6"/>
    <dbReference type="STRING" id="1365484.W6Q9U6"/>
    <dbReference type="OMA" id="WRRLWYI"/>
    <dbReference type="OrthoDB" id="4236860at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Amide_Lactam_Regulators"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
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        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47171:SF4">
        <property type="entry name" value="ACETAMIDASE REGULATORY PROTEIN"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
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    </dbReference>
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        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
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    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="26"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="76"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM26557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="753" mass="85247" checksum="B34EC90C8ABA8362" modified="2014-04-16" version="1">MSSVNDNAPSPLPVDGVSKRKQGSAACVHCHRRKVRCDARTVGTPCTNCRASGKADCRIHEKKKRLAVRSILDPVPIRSRPLPTSDPTSNPTLAAGTPLPPSFPTAFQSGHATPISGGLPQHGFQQGTGSEAFGRPDMAHAREAHTEMEQHLVKLIDEEESGRREIQRGVRAFYVGHEHSNMSFLFRQQREQDDDVYHFASNEIPRRQMKTGHDQLLMDALTLPEPALADELVQAYFTYVNPGYPIIDEDLFMTQYRNRDPADPPPVLLLQAILLVGAHVSRAKVERDALKEIFFRRTKYLFDNRIERNRDILVQAALLLTWHSDSADDDVAADAHFWVGAAARIATGLGMHRNPVSSRFVTRDRRMWRRVWFILVQFDVLISLSYGRPQAINLDDSDVSPLTLADFENCGPLVQADYVIHFTELCTMISYLIRDRFGLRAKRRKAVLQEADGSLATWSLKLPDNLRLRASDMDPWSAMLHLTYNNFLILLHRPHPRASAYSDDYGPHDAEICSAAAGVIASIFEELRMHERLKFLWYTGVHTLFTAMIQVRVELRFSNPVLAINALRRFDSASYSLRELAQYWVHAGTILRLFEDSKRLQEDLRMATTERPKPFNDTHHAHKMPITSPVPSITMQTPGPLSFGVPTPESTPLQQTTLSPQPNPQFNNWIAPLRLNVGPLERNDPFSASMQVDSIEPARDYPDWRQLFAFGDVDLPPPVGVEGLPELEDEWRQIYWQDAPMADLIHDGGWLHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W6QA05</accession>
    <name>W6QA05_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S02g002972</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QA05"/>
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    <dbReference type="Proteomes" id="UP000030686">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="271"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="322"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="405"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM32821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="439" mass="49230" checksum="229F33DFFF6C1BDE" modified="2014-04-16" version="1">MPLGSLARWQSALFCLVRFSNADFQTEMPTIVVATSLFSLLFLFMFEYTDGSVIAALAILETPTSIEDENPQETGLFVVGKIEDPPTGRSGRTTRDESENAREFLWSLRHNSIRELFPTLCGGFLGLAGLFVLSLAGVIDSDPNNIVTGFLICGSIMIMGNIFTISTTSNAVTNQRSLARRHLHNERGFWFIFTGLEEFMIYMLLTVVIMALSKPISAEDGATFPVLGLSRLLLGLSLTNLHAAWVHTVVSKPRKQTIWQRIPGWREWLEILPVAFLDIVLPNCVHYLATTLLAFFRGVVFAALSNQAYERIPYPLTTCANIVFHAIPIVSEYSASILTGAMYVRVAASMLPENEQTVVPFDRSFGGRAKNGTRCLSILDAFRTMKVQNWYRYLKNGWEVLIREYVWVCFSIIVIAMELYLWAPCTAVDLLACLRQHIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W6QA98</accession>
    <name>W6QA98_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S03</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S03g000317</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QA98"/>
    <dbReference type="STRING" id="1365484.W6QA98"/>
    <dbReference type="OMA" id="ECSIMER"/>
    <dbReference type="OrthoDB" id="529367at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM33593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="191" mass="22228" checksum="86852C440327A6A2" modified="2014-04-16" version="1">MRLMYGAFPPDGWQKLYKQAYDALEPGGWIEQIELDVRVYSDDGTLTKEHQLYGWGDIFIGCSERAGRSLRTHETMRSAIEEAGFVDVHEEKYKIPLGCWARDNILKEAGHLQHSHWNAALEGWAMWLLTHFGEPEPWSKEEVQVFLVKVRKELNNPRIHAYEPANRVWARKPLKEELKVEEVKIKAEKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W6QAD8</accession>
    <name>W6QAD8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S02g003137</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QAD8"/>
    <dbReference type="OrthoDB" id="4240420at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM32986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="67" mass="8046" checksum="B2B94E5804F39857" modified="2014-04-16" version="1">MKIKFTGNEPGSYFVCVWSYLLPAKRRININTLCTNCLEETNLLSSKDQREFIYKKKDHFIFKRRVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W6QAU9</accession>
    <name>W6QAU9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S02g003318</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM33166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QAU9"/>
    <dbReference type="STRING" id="1365484.W6QAU9"/>
    <dbReference type="OMA" id="GYEIHSH"/>
    <dbReference type="OrthoDB" id="4368597at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004879687" evidence="2">
        <location>
            <begin position="20"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="356"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="372"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM33166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="407" mass="34274" checksum="BCB7E938C2E9D1B9" modified="2014-04-16" version="1">MHFTAPSVALLALAAGVQAGSKQLQGPPVHVKGIIGKQRVEPGTDVAPTGAQTGTHPIGTGIVGTGTSTGSHPIVTGTPGGPGGGVGNNSTIIVTGTSPCYTCHGSATIPVYVPTRTQGTSPSGGAGSGTGSGSGTGSGSGTGSGSGSGSGSSSGPGSGSGSGSGSGSGSGSGSSSGPGSGSGSGSGSGSGSGPGSGSGSGSGSGSGSGSGSSSGPGSGSGSGSGSGSGSGSGSSSGPGSGSGSGSGSGSGSGSGSSSGPGSGSGSGSGSGSGSGSGSSSGPGSGSGSGSGSGSGSGSGSGSGSGSGIEGSGSGSGSGSGSDSGSGIEGSGSGSGSGSVGSGGVNGSGSTSGAGKGASPSSPVSTSGSDSTNDYSLSSPGSKVTAPQIGVVSAVIGSMVYGTIMLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W6QAW9</accession>
    <name>W6QAW9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Mannose-6-phosphate receptor binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PROQFM164_S03g000542</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QAW9"/>
    <dbReference type="STRING" id="1365484.W6QAW9"/>
    <dbReference type="OMA" id="RTKSTIM"/>
    <dbReference type="OrthoDB" id="4504960at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.130.10:FF:000024">
        <property type="entry name" value="Putative vacuolar sorting receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.130.10">
        <property type="entry name" value="Mannose-6-phosphate receptor binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028927">
        <property type="entry name" value="Man-6-P_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009011">
        <property type="entry name" value="Man6P_isomerase_rcpt-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044865">
        <property type="entry name" value="MRH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15071:SF0">
        <property type="entry name" value="MANNOSE 6-PHOSPHATE RECEPTOR-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15071">
        <property type="entry name" value="MANNOSE-6-PHOSPHATE RECEPTOR FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02157">
        <property type="entry name" value="Man-6-P_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50911">
        <property type="entry name" value="Mannose 6-phosphate receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51914">
        <property type="entry name" value="MRH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004881412" evidence="10">
        <location>
            <begin position="24"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="MRH" evidence="11">
        <location>
            <begin position="33"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDM33818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="337" mass="36537" checksum="091224E9056A6915" modified="2014-04-16" version="1">MRLTSSAHYSIFLLSSILGLSSASYSSHFEDDAPCVARSPTTGLYFDLNAISLSPPKMKDGNKLSKDARTESWYARGHDYPANFTINICAPVIENVTDVVGIESSRWKNVSAYYERDDKRYSIGQQASEPFFRGRKLVLNYTNGSPCPDNYNTGSSNASTRNKSTIMSFLCDRDAAPNVATASFVGSMDECSYFFEVRSSAACGGIAVDPNAGGLGPGGVFGVIMVIAIAVYLIGGCAYQRTVMHQRGWRQCPNFSLWAGVFDFVKDMFVILFSSLGNLFRCRGSAAGNGYTRADSDGRGGFIGAIGGRGGRGGRGQGRDVDAENRLIDQLDEEWDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W6QB81</accession>
    <name>W6QB81_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S02g001549</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QB81"/>
    <dbReference type="OMA" id="REECCLA"/>
    <dbReference type="OrthoDB" id="4135672at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046670">
        <property type="entry name" value="DUF6540"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20174">
        <property type="entry name" value="DUF6540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM31399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="148" mass="17032" checksum="3BDE85F166EB12A2" modified="2014-04-16" version="1">MALKVFTTESIGAQRNHIAIYIETDPSEDRGWLHHVTGTILNGMDYTPRPTPNPEVLPEHVPDSKKEIGTIEEADLERFREECCLAVPPPRAQVTLKGTRLYPDTPLYRCGDWLKDVEEMAFRKGILKSLLRFHTRHIRVRTPMLVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>W6QBI8</accession>
    <name>W6QBI8_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="7">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PROQFM164_S03g000115</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12 13 7">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the PPP phosphatase family. PP-Z subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="7"/>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QBI8"/>
    <dbReference type="STRING" id="1365484.W6QBI8"/>
    <dbReference type="OMA" id="AEIMAIC"/>
    <dbReference type="OrthoDB" id="1930084at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07414">
        <property type="entry name" value="MPP_PP1_PPKL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000006">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050341">
        <property type="entry name" value="PP1_catalytic_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031675">
        <property type="entry name" value="STPPase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668:SF484">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE PP-Z1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16891">
        <property type="entry name" value="STPPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="9">
        <location>
            <begin position="302"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="493"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="46"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDM33391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="512" mass="55800" checksum="E08BCE508474DAD9" modified="2014-04-16" version="1">MGQSHSKGNASGDTLQSYPSFSKSDTKESLRSFRGSIRSKIPGARSSDSPRGSTTALSRTESQTDKSDAGSLKSVGSRPGSNAGLPSPGSEDASRPGTPQPPPSPSLSTSLQRGHKDVNVMKQSGEVDLVSDNPPTGGPPTGASAVAGESILMKRENQLNPILDFILNAPLETSGSPGMGMGALKSIDLDDMISRLLDAGYSSKVTKTVCLKNAEITAICTAARELFLSQPALLELSAPVKIVGDVHGQYTDLIRLFEMCGFPPAANYLFLGDYVDRGKQSLETILLLMCYKLKYPENFFLLRGNHECANVTRVYGFYDECKRRCNIKVWKTFIDTFNCLPIAAIVAGKIFCVHGGLSPSLSHMDDIRGIARPTDVPDYGLLNDLVWSDPADMEEDWEPNERGVSYCFGKKVIMDFLQRHDFDLVCRAHMVVEDGYEFYQDRILVTVFSAPNYCGEFDNWGAIMSVSGELLCSFELLKPLDSTALKNHIKKGRNKRNSMLNSPPAAVSAQSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W6QBR2</accession>
    <name>W6QBR2_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S02g001744</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QBR2"/>
    <dbReference type="STRING" id="1365484.W6QBR2"/>
    <dbReference type="OMA" id="HKYNDEE"/>
    <dbReference type="OrthoDB" id="4317845at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM31594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="148" mass="17465" checksum="6018DA0CD81E6AB0" modified="2014-04-16" version="1">METPISSVDSSPVTKEAKKRTKLQGMFNYPDGRNIREKHYPAGRNQWVTVFFNWADHQLDDEDLMDLVVARIVARDGIISSEPVHHDVKWCLSLRVPGYWNLSDIEIASTAKDIAKWYRSEIRHAGMQINRRYLFRRNNRRKMRHGVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W6QBT2</accession>
    <name>W6QBT2_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Probable endonuclease LCL3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Probable endonuclease lcl3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">lcl3</name>
        <name evidence="17" type="ORF">PROQFM164_S01g000921</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the LCL3 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QBT2"/>
    <dbReference type="STRING" id="1365484.W6QBT2"/>
    <dbReference type="OMA" id="IYHTPGG"/>
    <dbReference type="OrthoDB" id="430293at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.90:FF:000029">
        <property type="entry name" value="Probable endonuclease lcl3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035437">
        <property type="entry name" value="SNase_OB-fold_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016071">
        <property type="entry name" value="Staphylococal_nuclease_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12302">
        <property type="entry name" value="EBNA2 BINDING PROTEIN P100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12302:SF3">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00565">
        <property type="entry name" value="SNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00318">
        <property type="entry name" value="SNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50199">
        <property type="entry name" value="Staphylococcal nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50830">
        <property type="entry name" value="TNASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0106">Calcium</keyword>
    <keyword evidence="9 17" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="TNase-like" evidence="16">
        <location>
            <begin position="83"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="257"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="260"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="15">
        <location>
            <begin position="281"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CDM27112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="300" mass="34132" checksum="3BFB1C4BA2F7D8C7" modified="2014-04-16" version="1">MRWPPWSSESTNDDQKQTPGSWLSSAANNPSSIFDWTAFTEVRTIVPTLVLTSGILIAVRFHRRYLRRIPDAPSISSSYLRRRSIFGQVTSVGDGDNFRIFHTPGGRMAGWGWLPWKKVPTVKKDLKDKTIHIRLAGVDAPELGHFGHPEQPFARDAHAWLTSYLSGRRVRALVYRQDQYSRVVASVFVRRAFDFPPFRRRDVSYEMLKRGLATVYEAKVGSEFGGEKMEKKYRKAEWQAKKRARGLWKDYGRVGSAWESPREYKKRIGMEDPPPMEKGNGKGNGKGNGKGNGKGKTGQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2024-10-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>W6QBY0</accession>
    <name>W6QBY0_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S03</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S03g000932</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QBY0"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM34208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="64" mass="7387" checksum="62772ADBC02BAD1C" modified="2014-04-16" version="1">MLAAPIPYLPNVYQFRSVSYFSYHYWVLNPDDDKFPHSRKCAGVDRCLPLDTQSNGDLYGMLTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>W6QCD0</accession>
    <name>W6QCD0_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">ATP-dependent RNA helicase SUB2</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">ATP-dependent RNA helicase sub2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">PROQFM164_S01g001081</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">ATP-binding RNA helicase involved in transcription elongation and required for the export of mRNA out of the nucleus. SUB2 also plays a role in pre-mRNA splicing and spliceosome assembly. May be involved in rDNA and telomeric silencing, and maintenance of genome integrity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the DEAD box helicase family. DECD subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QCD0"/>
    <dbReference type="STRING" id="1365484.W6QCD0"/>
    <dbReference type="OMA" id="YAHVEPK"/>
    <dbReference type="OrthoDB" id="10265785at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17950">
        <property type="entry name" value="DEADc_DDX39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000111">
        <property type="entry name" value="DEAD-box ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000168">
        <property type="entry name" value="DEAD-box ATP-dependent RNA helicase 56-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 23" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="11" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="22">
        <location>
            <begin position="59"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="20">
        <location>
            <begin position="90"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="21">
        <location>
            <begin position="293"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="15"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="18">
        <location>
            <begin position="59"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="17"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00037698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00038213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00040177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00040402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="CDM27272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="442" mass="49940" checksum="DF9BBCADB5D3C63C" modified="2014-04-16" version="1">MSHEEDLIDYSDEELQTTTAPATTAAPAATNGDADKQGDLTVTGGRPDKKGSYVGIHSTGFRDFLLKGELLRAITDCGFEHPSEVQQVCIPTSILNVDVLCQAKSGLGKTAVFVLTTLHQLEPVPGECQILVMCHTRELAYQIKNEYARFSKYLPDVKTAVFYGGTPIQKDVEILSNKETYPNIVVATPGRLNALVRDKKLSLRNVKAFVLDECDKMLDQIDMRRDVQEIFRATPADKQVMMFSATLSQEIRPICKKFMRNPLEVYVDDDTKLTLHGLQQYYIKLDEKEKNRKLNELLDNLEFNQVIIFVKSTQRANELDKLLRECNFPSIAVHSGVSQEERIKRYKEFKEFNKRICVATDVFGRGIDIERINLAINYDLPADADSYLHRVGRAGRFGTKGLSISFVSSEEDEKVLKEIEKRFEVALPEYPEAGVDSTTYMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W6QCF9</accession>
    <name>W6QCF9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Serine hydrolase FSH</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S02g002015</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QCF9"/>
    <dbReference type="STRING" id="1365484.W6QCF9"/>
    <dbReference type="OMA" id="LHGHGTS"/>
    <dbReference type="OrthoDB" id="2094269at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005645">
        <property type="entry name" value="FSH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050593">
        <property type="entry name" value="LovG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070">
        <property type="entry name" value="ESTERASE OVCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070:SF7">
        <property type="entry name" value="SERINE HYDROLASE FSH DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03959">
        <property type="entry name" value="FSH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine hydrolase" evidence="2">
        <location>
            <begin position="2"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM31864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="280" mass="31181" checksum="6A86736CF6DEBEB4" modified="2014-04-16" version="1">MKWLCIHGTGSSATIFQDQLAAVTAHLPPSKHAFHFIDGPFTSKPAAGLDLRYPDGPYYTWWLKATVSDIRAACQDFHKYLTQHNNVPYDGMVCFSRGCLLIASYIWFHQIEKPTEPLPFKAVVFICGGPVLSVLETLGMTISDEAREWDKRTKLALRERASKEAILKWGRDRWTTPGGNGDTDLHLNPAAPVDPSDIFGLDTVQMPEQLRIKIPTLHVYGRVDPRLPASLQLAYLSESTKRLTYQHEGGHNIPRSAAATEGIARLIDECAQMVAGLDVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W6QCH8</accession>
    <name>W6QCH8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Annexin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PROQFM164_S03g001127</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the annexin family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34403.1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
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    <dbReference type="GO" id="GO:0012506">
        <property type="term" value="C:vesicle membrane"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="F:phosphatidylserine binding"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Annexin"/>
        <property type="match status" value="4"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR018502">
        <property type="entry name" value="Annexin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037104">
        <property type="entry name" value="Annexin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009117">
        <property type="entry name" value="ANX14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10502">
        <property type="entry name" value="ANNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10502:SF102">
        <property type="entry name" value="ANNEXIN B11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00191">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00196">
        <property type="entry name" value="ANNEXIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01813">
        <property type="entry name" value="ANNEXINFUNGI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00335">
        <property type="entry name" value="ANX"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47874">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51897">
        <property type="entry name" value="ANNEXIN_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0041">Annexin</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="7"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="32"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="74"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDM34403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="430" mass="47000" checksum="702CF74ADDA5DCCF" modified="2014-04-16" version="1">MSYQPNQAPYGGYAPQYGQQGPPQGGYQQPYGAPPPQGHYPPPQQGHYPPPQQGHYGAPPPQGAPYGAPPPQPHGYHAPPAQPPYGQQPHGYAPPGQPPVGYGAPPSGGGFPPQGIPSQPSPGYIPGQLAPGEFRPQADALRKAMKGFGTDEKALIAVLAPLDPLQMAAVRDTYSKHLGRDLFKDVKSETSGYFGDGLLAVLDGPLMNDVDNLHSAIDGAGTKEWLLNEILLGRSNADMNAIRTAYEMRHRRSLSKDVEGDLSFKTSTLFAIVLRAARHEESTPINPQTIETDVRSVQGKNVTEVCAIFAQASNAELRAISQTFESRYHISLEKHIEKAFSGHMEDALLLMLRTATDPAMRDAILLEQSMSGMGTKDERLIIRVVRVHWNRNHKEMVKRAYQHKFGKSLIDRVRGETSGDYQRLMVALLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W6QCP5</accession>
    <name>W6QCP5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PROQFM164_S02g002115</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="4368459at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052374">
        <property type="entry name" value="SERAC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48182">
        <property type="entry name" value="PROTEIN SERAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48182:SF2">
        <property type="entry name" value="PROTEIN SERAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="427"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="546"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="666"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="690"/>
            <end position="1154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1177"/>
            <end position="1501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="730"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="751"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="821"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="850"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="883"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="973"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="1001"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1015"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1062"/>
            <end position="1072"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="1073"/>
            <end position="1090"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1124"/>
            <end position="1139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1141"/>
            <end position="1154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1197"/>
            <end position="1228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1237"/>
            <end position="1501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM31964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="1501" mass="157628" checksum="862EC16DF2AEEE86" modified="2014-04-16" version="1">MATYMAPIPPSGQGLTARLVRQTKIPKPDKHDESKAIDIVAVHGLAPWESYPDTSFWLRDFIAKDIRGARVFTFDYDAKAVWLCELPLKNIQDVSRALLGQIAAIREDVPETRPLALICHGFGGFIVESCLNDAFSQFPNTIDCTRGIIFLSTPQRASPGITWATLLLRCARDSIRTPPGLTQAELAYSQDLVWAKRSGVVLCDISEGFKAKVTKRMKLFFCYEDVPTWPQQECSLNEYCAALGRRGEKVELMAGCSHLSMANFQSREDENYKTIISAIKKIRKLALKDTAPTSSGLHETAQEIQNLQVIQSSQATSIHTVQNTSVLNQQNFSLQNAVTATHNTFGARELSHGSSQGTMIALKKSGPAYGNMQDASRIYSATPQSSQFDANMMKIRRRPPNIPSQNLQFTSGQLGQQTQHYANIAPITALEPKSSTKSGKKPKMPQEAGPPRPAKLPLNPGDAAPRPAVVRQLIGNEGMLSTSSNIHRTDQQMHYTTINSMAMSSSQHISPQPSSGTYNYPPVPHPFPTNHPMTLTAGAMPVQLTSPQKVTKPPKASSGEQRPEPAKLPGTNPMPHQMRPNKVDSGVRGPPIPTTTAGTIPKVAPMQAPPTVQQGLRELQLQPSYTRLAILHPPRSPGFLKGFFRLARNRHLSLPQEVLECAREYKSVHTSRPGRPAGEALGYTRGLNLGGPGVYSGPQVGSHQPLKPSKPSSKSPPGPTSLGDPGVHSGPQVGLQQPLKPLKPLKPSKPAKPSSKSPSGTTSSSGPGVHSGSLGGPHQPLKPLKPSKPSKPSKPSKPSSKPPSGPPKLVGPGVYSVSQGGLHQPLKPLKQLKPLKPSKPSSKPPSGPTSLGGPGVYSGSQGGPHQPFKPSKPSKPSILGGSEVNSGSRGLSQQPYKPYKPSMPTSLRGPGVHSGSRDGPYQPYNPLSHTHLSPYGPPRPGQGPLIHGHNNNDHFGPGQHQTWGHGDGFNFAPGQTSSHITSNIPVEPPAKPTGSVEPTGPIKPPGPVEPPVEPTGPVEPTGPVEPTGPVEPTGPVEPTGPVEPTSPVEPTDPIKPPGPVEHPVEHPVEHPIEPPVKPTGPIKPPGPVEPPVEHTGPVEPISPIKPIGPVQHTGPAEPIGRGFTPDESHGQAWKPDHSRNQAHQSQSLNQSSRSGNIAAGLAGLAIGAGGAAFMVASMGQGKENDESNVNDDNNHEGDDDSDSQGEGGGDSDSDSDSDGDSDEDDSDGQEAVGGYGDSEEEGSDGQEEEGGGDSDEEDSEEGGGDSDEEDNGGGDSDEEDSDGQEEEGGGDSDEDGGGDSDEEDSDGQEEEGGGDSDEDGGGDSDEEDSDGQEEEGGGDSDEDGGGDSDEEDSDGQEEEGGGDSDEDGGGDSDEEDSDGQEEEGGGDSDEDGGGDSDEEDSDGQEEEGGGDSDEDGGGDSDEEDSDGQEEEGGGDSDEDGGGDSDEDGDGDSEEEGSDGQEEEGGGDSDEEDSEEGGGDSDGEDSEEGGDYSDEEADGGWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W6QCU6</accession>
    <name>W6QCU6_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S03g000610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QCU6"/>
    <dbReference type="STRING" id="1365484.W6QCU6"/>
    <dbReference type="OMA" id="HSHAFQN"/>
    <dbReference type="OrthoDB" id="4498621at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM33886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="189" mass="19835" checksum="4BC6EC06D5919495" modified="2014-04-16" version="1">MAEGARNADSDRDTAQLVKEHSGAFQNRVNTTQTDSPPIPETAKPDIDTDQLKADAGLETPEPAPETEPSVTEPAGSALGNIPIAHESQVPVGPTNETVPGEKRGIDSALAEDEQRKPEPSDGPDTKKLKTDEDHVTGSNGTAAAASNPDNKEQKKAGRSKKEKIKDAVNKIVPGDGVGSRTRSRTKGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W6QDW6</accession>
    <name>W6QDW6_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S03g001420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QDW6"/>
    <dbReference type="STRING" id="1365484.W6QDW6"/>
    <dbReference type="OMA" id="WMDGLKL"/>
    <dbReference type="OrthoDB" id="566138at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005127">
        <property type="entry name" value="PRK06565.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42678">
        <property type="entry name" value="AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42678:SF11">
        <property type="entry name" value="AMIDASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="1">
        <location>
            <begin position="32"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM34695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="678" mass="72713" checksum="21D447A52CE802EE" modified="2014-04-16" version="1">MSHQSQDLSLLDASISELQSALSSGLLSSVGLVSRYLQRISVYDASNLKLTAIPLLNPAALDEAAASDAWRAAGLPPRPLEGIPFLAKDSIKVKGMTVASGSPAFETLVANEDAACIQLLREAGAVLLGRTNMPAMAYGGMQRGCYGRAESPYNTAYLAAAYASGSSNGSAVATTANFCAFSLGSETVSSGRSPASNNAVVAYTPSKGLLPLRGVWPLYLTCDVLVPHTRTMADMFHVLDVLAVSDKAPTGDFYQEQKLISLPSIDTLRPQSFSELQDGTSLRGKRIGVPSMYIGGDNCSLSPASRVNTRPSIIKLWKNARKALESCGAEVIETDFPIVTTYESNADKGQLVTVAGLPEGWSALERSELVAHIWDDFLINNGQKGLDSLSKVDPTTIFPLAPGSLKGAPDAANALRWDEMVQYPHRRPASVFDIPGIQQGIQALENARKETFEDWMDGLGLDAVVFPANGDIGAADADCDEAASLFAWSNGVKYSNGNRPIRHLGVPTISVPMGLMEDTGMPVNLTFAGKAYDDNSLLKYGFSFEMAMKGRVKPPLVPALDSDLIKGGQDPRPWASRSTVELVVETQVKKIQDSTVVVQIQGSVVPKDSQLETMECHINGQVFKPAIEGDRWFIIASYPASERDQPWKRWSSPALTQTIIVITAHTKDGSTTGKLILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W6QE82</accession>
    <name>W6QE82_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Hydroxyquinol 1,2-dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">chqB</name>
        <name evidence="9" type="ORF">PROQFM164_S03g001497</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the intradiol ring-cleavage dioxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QE82"/>
    <dbReference type="STRING" id="1365484.W6QE82"/>
    <dbReference type="OMA" id="RCVMRSD"/>
    <dbReference type="OrthoDB" id="5238185at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018576">
        <property type="term" value="F:catechol 1,2-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009712">
        <property type="term" value="P:catechol-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03461">
        <property type="entry name" value="1_2-HQD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.130.10">
        <property type="entry name" value="Aromatic compound dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039390">
        <property type="entry name" value="1_2-HQD/HQD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007535">
        <property type="entry name" value="Catechol_dOase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000627">
        <property type="entry name" value="Intradiol_dOase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015889">
        <property type="entry name" value="Intradiol_dOase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050770">
        <property type="entry name" value="Intradiol_RC_Dioxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33711">
        <property type="entry name" value="DIOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G02910)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33711:SF7">
        <property type="entry name" value="INTRADIOL RING-CLEAVAGE DIOXYGENASES DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00775">
        <property type="entry name" value="Dioxygenase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04444">
        <property type="entry name" value="Dioxygenase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49482">
        <property type="entry name" value="Aromatic compound dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Catechol dioxygenase N-terminal" evidence="8">
        <location>
            <begin position="32"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="Intradiol ring-cleavage dioxygenases" evidence="7">
        <location>
            <begin position="117"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM34770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="329" mass="36781" checksum="8FF98FD706F81E13" modified="2014-04-16" version="1">MDPSKIKIPPMKDQTVDNITANVITINSLCPDPRLKYILERLVTHLHDFARETRLSSAEWMTGLNFLTEVGQACTDVRQEYILLSDVLGLSILVDSIDHPKPKGSTEGTVLGPFHTHDAEEMPAGASMSHDPHGEPLLVVCSLRDLQGAPVHDVKVDIWETDSTGHYDVQYAGRVGPDGRCVMRSDQDGVFWFMAITPVPYPIPHDGPVGRLLEMLRRHPYRPSHMHFMFEKEGFDHLVTALYLRNDPYETSDAVFGVKDSLTVEIGKADAEIARKYNVPEGHALLTYDFVLVSDEETKELRAHNSKVALDKLGRKVKIVNGLPVPDLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W6QEQ9</accession>
    <name>W6QEQ9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S02g002840</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QEQ9"/>
    <dbReference type="STRING" id="1365484.W6QEQ9"/>
    <dbReference type="OrthoDB" id="4337659at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM32689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="154" mass="17625" checksum="A132781075A699D8" modified="2014-04-16" version="1">MLDVVSKQAYRQGRSPKTRFSWELAGFASAYETVPHVQNQFNRAIPGSPKCFLELMEQVIYPSFLKLLECYYYDVSYTLIWELTEVSVSHILASSYSITTDELVGIVKPSSDIKIMGVENSCEIKESEMNPAMMKLYALADVITKLMLKNRIYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>W6QEU5</accession>
    <name>W6QEU5_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Class E vacuolar protein-sorting machinery protein HSE1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Class E vacuolar protein-sorting machinery protein hse1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">hse1</name>
        <name evidence="16" type="ORF">PROQFM164_S03g001295</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the ESCRT-0 complex which is the sorting receptor for ubiquitinated cargo proteins at the multivesicular body (MVB).</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the ESCRT-0 complex composed of HSE1 and VPS27.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the STAM family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QEU5"/>
    <dbReference type="STRING" id="1365484.W6QEU5"/>
    <dbReference type="OMA" id="QVYRDWW"/>
    <dbReference type="OrthoDB" id="10255964at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033565">
        <property type="term" value="C:ESCRT-0 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21386">
        <property type="entry name" value="GAT_Hse1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11805">
        <property type="entry name" value="SH3_GRB2_like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16978">
        <property type="entry name" value="VHS_HSE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000072">
        <property type="entry name" value="Unconventional Myosin IB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004152">
        <property type="entry name" value="GAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050670">
        <property type="entry name" value="STAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002014">
        <property type="entry name" value="VHS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45929">
        <property type="entry name" value="JAK PATHWAY SIGNAL TRANSDUCTION ADAPTOR MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45929:SF3">
        <property type="entry name" value="JAK PATHWAY SIGNAL TRANSDUCTION ADAPTOR MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03127">
        <property type="entry name" value="GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00790">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00499">
        <property type="entry name" value="P67PHOX"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00288">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50179">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0967">Endosome</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="domain" description="VHS" evidence="15">
        <location>
            <begin position="16"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="14">
        <location>
            <begin position="223"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="198"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="381"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="420"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="448"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="472"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="498"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="546"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="563"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="576"/>
            <end position="585"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CDM34571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="615" mass="67811" checksum="8682E657204FE48C" modified="2014-04-16" version="1">MFRAQQNHFDEAVAKATDENLTSENWEYILDVCDKVGAEESGAKEAVAAMIKRLAHRNANVQLYTLELANALSQNCGLKIHRELASRSFTDALLRLANDRNTHQQVKSKILERMEEWTEMFSSNPDFGIMEQAYMKLKTTNPNLQPPSKPGKREITDVDRQMEEEELQMALALSIKDKATPAAASAAAPRAEAPSAAVASASAATTQGEPAETQPALSGTSVATVSRVRALFDFQPSEPGELQFRKGDTIAVLESVYKDWWKGSLRGQTGIFPLNYVEKLPDPTVDELQREAQMEADVFGQIKSVEKLLTLLSTRNTDLNVQENEEITTLYQATLAIRPKLIELIGKYSQKKDEFTQLNEKFIKARRDYESLLEASLAHPAQPQYGRPAQPQYGYPSAAPAGYPTPQADPRYFTPRPQDTTPAPANAYAPYPTSEQMPYRPASHSPDPRNQSQAGASQQPPHGDPYQPVSHRPQSTYDHPQELGTSVYDSPVERISYPQAGQAPPAGHQQFQHQQHQQQDYSPSAYSTDEAPQGPPAASMPQIAHQFQQQQQQAPYPSSPGAHQPPPSHQPPPVPGASQPQYTSYSPPPPAASTGEYQAYQPQGGPGSNPASFYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2024-10-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>W6QFF0</accession>
    <name>W6QFF0_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S04</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S04g000409</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QFF0"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM35528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="49" mass="5526" checksum="2E8B83FD4076785B" modified="2014-04-16" version="1">MTISLAPTTTGSTKKPLAQLVWLIFAFTPELPRHVCIGLRRVYPVRHAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W6QFS5</accession>
    <name>W6QFS5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Protein spt3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">spt3</name>
        <name evidence="8" type="ORF">PROQFM164_S03g001533</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the SPT3 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QFS5"/>
    <dbReference type="STRING" id="1365484.W6QFS5"/>
    <dbReference type="OMA" id="QFMFNEQ"/>
    <dbReference type="OrthoDB" id="66982at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22926">
        <property type="entry name" value="HFD_SPT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000023">
        <property type="entry name" value="transcription initiation protein SPT3 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003195">
        <property type="entry name" value="TFIID_TAF13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11380">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID/SUPT3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11380:SF16">
        <property type="entry name" value="TRANSCRIPTION INITIATION PROTEIN SPT3 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02269">
        <property type="entry name" value="TFIID-18kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0010">Activator</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="245"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00061274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM34806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="322" mass="36854" checksum="60683C8EF461472D" modified="2014-04-16" version="1">MSSDRNPKYRQEIQQMMFVSGETAEPAQETTTLIEEITRQQVIEILTRSTALATRRGVRSISTDDLIFLIRHDRAKVSRLRTFLSWKDVRKNVKDSDDKGGGDAADFAAADDAAGVVAGPQDVAPKPKNKRAKVGLAWDVNSFYSVQVPEREDEEDEEEEEQNYATLQRLAAADERTRHMTREEYVFWSECRQASFTYRKSKRFREWAGFGIVTESKPNDDIVDILGFLTFEIVQTLTEEALKVKEREDNEKHRRGGAEAGENLKKRKRETGLFDPPEEGRTPIEPRHVREAYRKLQATPQKAVAMLLHNGRVPHRIPLALI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W6QG49</accession>
    <name>W6QG49_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type DNA-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PROQFM164_S01g002438</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QG49"/>
    <dbReference type="OrthoDB" id="4222821at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="18"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDM28627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="55" mass="6262" checksum="B3B297E6947B03DE" modified="2014-04-16" version="1">MDSTRHESPQVEQPRRSACDRCRGQKLRCERLSPNSSIEDSCRRCLKVGARCPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W6QGL2</accession>
    <name>W6QGL2_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mediator of RNA polymerase II transcription subunit 10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Mediator complex subunit 10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">nut2</name>
        <name evidence="6" type="synonym">MED10</name>
        <name evidence="8" type="ORF">PROQFM164_S03g000038</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the Mediator complex subunit 10 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QGL2"/>
    <dbReference type="STRING" id="1365484.W6QGL2"/>
    <dbReference type="OMA" id="QYQRAKM"/>
    <dbReference type="OrthoDB" id="337270at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019145">
        <property type="entry name" value="Mediator_Med10"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09748">
        <property type="entry name" value="Med10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0010">Activator</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="55"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="63"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM33314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="172" mass="18697" checksum="6D02CC13AEE2A2BC" modified="2014-04-16" version="1">MAPVTLKTVDDDLKDVIQHLFEIQSAVHGYLGPETQQELVRKIKNLTLALSTLSTHTQLSPTQETQPDTNTDPSNPSLASIQLPPEIIDYVDSARNPDIYTREFVELVQRGNQDLRGKREAFASFRDVLAREMRSAMPECRSEVDRVVAATGGAVDGSGGVAEDAAMSGSGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W6QGM2</accession>
    <name>W6QGM2_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosomal protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpl-10a</name>
        <name evidence="5" type="ORF">PROQFM164_S01g002553</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QGM2"/>
    <dbReference type="STRING" id="1365484.W6QGM2"/>
    <dbReference type="OMA" id="GPRNKMP"/>
    <dbReference type="OrthoDB" id="2449818at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00403">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.790:FF:000002">
        <property type="entry name" value="Ribosomal protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.190.20:FF:000009">
        <property type="entry name" value="Ribosomal protein L10a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050257">
        <property type="entry name" value="eL8/uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002143">
        <property type="entry name" value="Ribosomal_uL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023674">
        <property type="entry name" value="Ribosomal_uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028364">
        <property type="entry name" value="Ribosomal_uL1/biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016095">
        <property type="entry name" value="Ribosomal_uL1_3-a/b-sand"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023673">
        <property type="entry name" value="Ribosomal_uL1_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23105">
        <property type="entry name" value="RIBOSOMAL PROTEIN L7AE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00687">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002155">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56808">
        <property type="entry name" value="Ribosomal protein L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01199">
        <property type="entry name" value="RIBOSOMAL_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDM28742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="217" mass="24131" checksum="CE524033D1F2ED0F" modified="2014-04-16" version="1">MSKITVAGVRQNVENLLNYSLNEKKRNFNETVELQIGLKNYDPQRDKRFSGTIKLPSVPRPNMAICVLGDQHDLDRAKHHGIDAMSVDDLKKLNKNKKLIKKLARKYDAFLASEGLIKQIPRLLGPGLSKAGKFPTPVSAAEDMAVKVTDVRSTIKFQLKKVLCLGVAIGNVEMEKEALVANLMLAINYLVSLLKKGWQNVGSLVIKASMSPPHRVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W6QGY5</accession>
    <name>W6QGY5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Permease, cytosine/purines, uracil, thiamine, allantoin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PROQFM164_S01g002683</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QGY5"/>
    <dbReference type="OMA" id="YAICPWY"/>
    <dbReference type="OrthoDB" id="2018619at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015205">
        <property type="term" value="F:nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11482">
        <property type="entry name" value="SLC-NCS1sbd_NRT1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.4160.10:FF:000001">
        <property type="entry name" value="Uracil permease, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4160.10">
        <property type="entry name" value="Hydantoin permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045225">
        <property type="entry name" value="Uracil/uridine/allantoin_perm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618">
        <property type="entry name" value="NCS1 FAMILY PURINE/PYRIMIDINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618:SF1">
        <property type="entry name" value="URIDINE PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="46"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="199"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="243"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="275"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="373"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="403"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="450"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="482"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM28872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="558" mass="61634" checksum="7B628227384C630D" modified="2014-04-16" version="1">MSKLSRLHELLLVKRTQRDGIERPVDMLDNDSIRPTSVKDRTWSQLTYIMFWFSATANVSNLYTASTGMAMGLTMWEAIGCSFGGQILAGALMAVNGRAGAMYRIPFPVLCRSSFGHWGALWPTFNRAVMSIVWNGVNTVQGGQCLYVFLHAIFPSIENIPDKMGSKSALTSAQMMCFFIYWLVNCAFLVVPVPRMKSLVYIKVVVYFGAAFAMLGWTVSLAGGSLKTINAPSEIKGTEKSYLIFKFLFLGLASCGTFISNASDLQRYATKPNDVLIGQIISFPLSNFLVAILGNLIASASKAIFGKLIWNPLQFLDKLMEGERYTSGNRTACAFISLAFVYSTVFSAIFENSIPAGNDIAALLPKYISIKRGFFICAVLSYAICPWYLLASASIFITFLSSYQIFLSAITGILICDYYLIRRGLLNIPALYISSPSPYRYFHGFNPRAFLTYVIAIAPNFYGFLFQMGVKAPLGIKRFYYIAYPTGLIIAFVVYYLSCLAFPPPDMKQASGWMEPKDFVEDHDASGSDESTIDAVDPDFAEKGAVAVARPAGEKGSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W6QH14</accession>
    <name>W6QH14_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 13">Small nuclear ribonucleoprotein Sm D2</fullName>
            <shortName evidence="13">Sm-D2</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 13">snRNP core protein D2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PROQFM164_S01g002713</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the heptameric LSM1-LSM7 complex, which consists of LSM1, LSM2, LSM3, LSM4, LSM5, LSM6 and LSM7. Component of the heptameric LSM2-LSM8 complex, which consists of LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8. The LSm subunits form a seven-membered ring structure with a doughnut shape.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the snRNP core protein family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QH14"/>
    <dbReference type="STRING" id="1365484.W6QH14"/>
    <dbReference type="OrthoDB" id="437526at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01720">
        <property type="entry name" value="Sm_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000018">
        <property type="entry name" value="Small nuclear ribonucleoprotein Sm D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027248">
        <property type="entry name" value="Sm_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12777">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN SM D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 13" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 13" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 13" id="KW-0687">Ribonucleoprotein</keyword>
    <feature type="domain" description="Sm" evidence="15">
        <location>
            <begin position="79"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="36"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00058057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00070085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU365051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CDM28902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="158" mass="17226" checksum="3A8DDBB6A68F1612" modified="2014-04-16" version="1">MSEPTASSESTASSASPASPASTAPSDSTASLDTSNLSEPTMSTAPEVQIQDLLNKPRSELTEYEVSLVESHELSAGPLSLLLTATRTHTQVLISCRNNRKLLARVKAFDRHFNMVLENVKEMWTEYPKGVKGKGVNKDRFISKMFLRGDSVILVLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2024-10-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>W6QH45</accession>
    <name>W6QH45_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S01g002753</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QH45"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM28942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="69" mass="7587" checksum="FCBE1DE51A3709C4" modified="2014-04-16" version="1">MFQGNWKGADPMRTWMAGLSGDPMLSFASSQDTRSQTGRLATLETSHLDGCMLFLAPTQTLLPDYTDIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W6QHG3</accession>
    <name>W6QHG3_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S04</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S04g000746</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QHG3"/>
    <dbReference type="OMA" id="PMATMRR"/>
    <dbReference type="OrthoDB" id="4256107at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM35865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="150" mass="16248" checksum="F815E137A7250C59" modified="2014-04-16" version="1">MGRWADFDAVEADKLGTCSVTAIVNEEGFLLSNTSSDGAREIPAAEALCALYNANKSLFGNKPVNVWTVYEQENADKGQCISPIMQRIKPARIFEQVYDGESFMNWPSEEGAKFSLKVVGGTVMATMRRQDGAGSAIPLYGDGTTVVSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W6QI83</accession>
    <name>W6QI83_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Spermidine/spermine synthases family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PROQFM164_S01g003089</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QI83"/>
    <dbReference type="STRING" id="1365484.W6QI83"/>
    <dbReference type="OMA" id="CFIGWAG"/>
    <dbReference type="OrthoDB" id="2016285at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000288">
        <property type="entry name" value="Spermine/spermidine synthase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051419">
        <property type="entry name" value="Lys/N-term_MeTrsfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF037959">
        <property type="entry name" value="MFS_SpdSyn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12176:SF59">
        <property type="entry name" value="METHYLTRANSFERASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12176">
        <property type="entry name" value="SAM-DEPENDENT METHYLTRANSFERASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01564">
        <property type="entry name" value="Spermine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="75"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDM29277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="548" mass="60717" checksum="9FB4B312D8EF694D" modified="2014-04-16" version="1">MSPQDMLRHIDARRFTTGVVLLILLAFYSPLSKLVLSPTYGSFPAHIFHNFGVAISGGIGWLLKDKILKRMGRLGGFMLPVLAFWVPTLQYFIKQQSSKIGNPTGPVVTELCGYYPLVLLTVAYAGKQIQTALRLEAQGDVIVEHVPLIGTYIFYSAGDHIAQYVLSWIVGTSVIFTRVGMQMLLAACYSVLIPSKWLVLAIPSIIFSVTSNVHFAGISGVNSAIEHEGYSLLARQEAYTGYISVLENHNEGFRVMRCDHSLLGGQWTKLAPGYRPEVDDPIYAVFAMLEAVRLVEPDNGVSRVDADSKALVIGLGVGTTPSALIKHGIETTIVEIDPVVHKFATQYFNLPPNHISVIEDAVKFVKKAQSSPNTPQYDYIVHDVFTGGAEPADLFTYEFLSGLHSLLKEDGAIAINYAGDVALYPTGLVVRTINAVFPSCRIFREEPTGDDEDTDFTNLVLFCKKSSNTPIQFRDPVPADFLRSKSRESYLVPKHELDPAIFASWPKGGRPILIAKQAGRLHKYQDRSAIKHWSIMRKVMPDAVWENW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2024-10-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W6QII2</accession>
    <name>W6QII2_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S03</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S03g000733</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QII2"/>
    <dbReference type="OMA" id="DGMVAKM"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004879853" evidence="1">
        <location>
            <begin position="21"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM34009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="136" mass="13350" checksum="8DFFA23BC6986E8D" modified="2014-04-16" version="1">MKFTTIVASLCLVAAPFVAAEETITSTATTTVTKTLVRVNSVTPTPTPITTSITTSVAGTMASTIANPSPSPSPSSSARYLSTMSVSTSTPLSRVASTTSAVPAATSIGAAANIGAGMPAALAVAGYIVVMVGQAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2024-10-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>W6QK85</accession>
    <name>W6QK85_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S03</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S03g001363</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QK85"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM34639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="53" mass="6075" checksum="34C2388D3F342A66" modified="2014-04-16" version="1">MRFGEIWSESLYIQDLLPSIQQSQWQATMQPRASTPYVVLLAGGRPRCFGTKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W6QKD7</accession>
    <name>W6QKD7_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">mRNA stability protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S02g000196</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Plays an essential role in initiation of the G0 program by preventing the degradation of specific nutrient-regulated mRNAs via the 5'-3' mRNA decay pathway.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the endosulfine family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QKD7"/>
    <dbReference type="STRING" id="1365484.W6QKD7"/>
    <dbReference type="OMA" id="RMYGKMP"/>
    <dbReference type="OrthoDB" id="5949865at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004864">
        <property type="term" value="F:protein phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006760">
        <property type="entry name" value="Endosulphine"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10358">
        <property type="entry name" value="ENDOSULFINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10358:SF6">
        <property type="entry name" value="ENDOSULFINE, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04667">
        <property type="entry name" value="Endosulfine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="52"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="80"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU363120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM30047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="162" mass="17150" checksum="C070114DA3A403A0" modified="2014-04-16" version="1">MNPHQQNKVDINSLSPEEQRLLRLYGKMPTKKDERKYFDSGDYALSKAGKASDLGVTNIGSRHPVPENIPHLISTSPGHNNSVSNGSVSSQGGQIPGSISGHPGSVGFQSRSPIKEGGSYLHRGTSISEGEAGSGLASEPVQSEQELSVSPPPAREGVPIRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>W6QLF7</accession>
    <name>W6QLF7_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Ubiquitin-conjugating enzyme E2 2</fullName>
            <ecNumber evidence="3">2.3.2.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">E2 ubiquitin-conjugating enzyme 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">Ubiquitin carrier protein UBC2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Ubiquitin-protein ligase UBC2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="primary">ubc2</name>
        <name evidence="24" type="ORF">PROQFM164_S07g000026</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="21">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="3"/>
    <dbReference type="EMBL" id="HG792021">
        <property type="protein sequence ID" value="CDM37678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QLF7"/>
    <dbReference type="STRING" id="1365484.W6QLF7"/>
    <dbReference type="OMA" id="DHKSQYI"/>
    <dbReference type="OrthoDB" id="9984419at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23790">
        <property type="entry name" value="UBCc_UBE2A_2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000007">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 21" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 21" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0749">Sporulation</keyword>
    <keyword evidence="13" id="KW-0804">Transcription</keyword>
    <keyword evidence="12" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 21" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="23">
        <location>
            <begin position="4"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="20">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00039884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00041569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00042179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00042190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="CDM37678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="152" mass="17248" checksum="13F36BFE94024DEA" modified="2014-04-16" version="1">MSTSARRRLMRDFKRMQTDPPAGVSASPVADNVMTWNAVIIGPADTPFEDGTFRLVMNFEEQYPNKPPGVKFISQMFHPNVYGTGELCLDILQNRWSPTYDVAAILTSIQSLLNDPNTSSPANVEASNLYKDNRKEYTKRVRETVEKSWEDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2024-10-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>W6QML3</accession>
    <name>W6QML3_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S02g000967</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QML3"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM30817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="59" mass="6600" checksum="CA4BD3B9F073FA72" modified="2014-04-16" version="1">MGPPVSWHAIGSSAFPSWTGLSSHWLTFMFRQAPYKSTYSVQSTLLSPSTAVNRWRGIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W6QN40</accession>
    <name>W6QN40_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Dethiobiotin synthase BioD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PROQFM164_S06g000327</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792020">
        <property type="protein sequence ID" value="CDM37366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QN40"/>
    <dbReference type="STRING" id="1365484.W6QN40"/>
    <dbReference type="OMA" id="KGWASRA"/>
    <dbReference type="OrthoDB" id="425114at2759"/>
    <dbReference type="UniPathway" id="UPA00078"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004015">
        <property type="term" value="F:adenosylmethionine-8-amino-7-oxononanoate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004141">
        <property type="term" value="F:dethiobiotin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009102">
        <property type="term" value="P:biotin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03109">
        <property type="entry name" value="DTBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001677">
        <property type="entry name" value="Bifunctional dethiobiotin synthetase/adenosylmethionine-8-amino-7-oxononanoate aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000122">
        <property type="entry name" value="Bifunctional dethiobiotin synthetase/adenosylmethionine-8-amino-7-oxononanoate aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000080">
        <property type="entry name" value="Bifunctional dethiobiotin synthetase/adenosylmethionine-8-amino-7-oxononanoate aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00336">
        <property type="entry name" value="BioD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049704">
        <property type="entry name" value="Aminotrans_3_PPA_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004472">
        <property type="entry name" value="DTB_synth_BioD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42684">
        <property type="entry name" value="ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42684:SF3">
        <property type="entry name" value="ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13500">
        <property type="entry name" value="AAA_26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDM37366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="786" mass="86293" checksum="80869FF0D4E9337B" modified="2014-04-16" version="1">MPPVGAALWRSLRAHQVYGANTDVGKTIISTVLCNAVQHQKQRAAFLKPVSTGALDDADDRHLRRYGAGTLTKCLYQFDDPVSPHLAAKDKFVPRDDDLLASIHNTLSGWARSDIDFALVETAGGVHSPGPNGNSQADLYRPLRMPIVLVADSRLGGISSSISAYESLLLRGYDISSVLVFRDEYYQNHEYLREYFQKKSIPLVSLPAPPARPSRLDADSQIRDEEAMFSYYQNSAKESEVLRLLEEMSVNNTERVQRLEEMADRAQELIWYPFTQHQGMKAKDITVIDSAHDDYFQTFGSNTSKDAEGELRPTFDGSASWWTQGLGHGNPELALSAAYAAGRYGHVMFAGAVHEPALTLADNLLKTIENPRFTKVFYTDNGSTGMEVAVKMGLRASCDRYGWDASQEQVGILGLKGSYHGDTIGVMDCSEPSTFNKKVEWYRGRGHWFDFPLVKMVGGSWKVEIPGELQGELGEDVDFASLGSVFDLSQRLESATAQRYKDYIRRTIEDLVQRQGVKFGALILEPVILGAGGMLFCDPLFQRCLTDVVRDHPELFSPNATAPKQSPSWSGLPVIFDEVFTGLYRLGRRTSASFLGVHPDVAVNAKLLTGGLVPLCTTVASEEIFNAFSSPEKSDALLHGHSYTAHAVGCTVAVDSLKTMAKLDTDGSWDAYRADWRSSSPATVESSAPEVWSVWSHGLLEDLSSTKSVESVFAIGTVLSISLRDAAGGGYNSNAAKGLQQKLAVGGDQFNVHSRVLGNVLYLMSSVTSKPESLRELERLLRSALV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W6QNM9</accession>
    <name>W6QNM9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Centromere protein Mis12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PROQFM164_S08g000061</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
            <location evidence="1">Centromere</location>
            <location evidence="1">Kinetochore</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mis12 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792022">
        <property type="protein sequence ID" value="CDM38010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QNM9"/>
    <dbReference type="OMA" id="EHFSYPP"/>
    <dbReference type="OrthoDB" id="1884855at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000444">
        <property type="term" value="C:MIS12/MIND type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051382">
        <property type="term" value="P:kinetochore assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000070">
        <property type="term" value="P:mitotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008685">
        <property type="entry name" value="Centromere_Mis12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14527">
        <property type="entry name" value="PROTEIN MIS12 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14527:SF2">
        <property type="entry name" value="PROTEIN MIS12 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05859">
        <property type="entry name" value="Mis12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="9" id="KW-0137">Centromere</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDM38010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="325" mass="35862" checksum="7E61229B6959AB66" modified="2014-04-16" version="1">MDDATTSLLTEHFSYTPLSLIDDIINSINNLIYQAISSLESGLLNTPPERLGFSHDSSGPSIAETDEDGNVVYPEAKLEIENGLHQLETLLETNVDKAFDKFEIYVLRNILTVPGDLLSWVRLKHYEGLSFVSSPDTPTPETIHAQRKKLFETKKLNRSLKEERARNDAVISQLQSILSTVETAKVDGVSKTAEDIPVDLSFLTSSPAARQLRVGVDAGSNAKPTPLTTNTTFILSQLPALQTTLEQLRPKLAALPNATVQIEAKSKRDERKEYIESRIRLHLERAGQLAVGDDGNPVVAGRRIDIREAHALESVANMLTQDKSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W6QP72</accession>
    <name>W6QP72_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AMP-dependent synthetase/ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S04g000775</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QP72"/>
    <dbReference type="STRING" id="1365484.W6QP72"/>
    <dbReference type="OMA" id="ADWNIYT"/>
    <dbReference type="OrthoDB" id="4138492at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272:SF11">
        <property type="entry name" value="AMP-DEPENDENT SYNTHETASE_LIGASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM35894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="565" mass="60854" checksum="8B0D6CB8E27BB41F" modified="2014-04-16" version="1">MADTSLVEKLDTLVADVLADWNIYTTIVAGIVLAFAVYSVVSSRDPDVHPFLLARQSTAAPIRKQGESATYRCLETPYGLPLRFGLNVKDPGAPKWTGGRRGDLRDIWKTAVRGAMNEDGTLSGNQGKIYTVLGRKAVEHSLDEVTQEINVIGHHLQTSGAKTVAVCLTDSIELLATIFGGAFYGYETVIVPHNLPAETLSAHLQQVKADVLIAEAGSLDLSLVAKGNNQLTLVLWVAKYGNQHMDWNALPENVEDTLKVAVWHELVEEFKEIASYDVPQYDPKTATPAVHTVWPSSSQSGQFIDFQPENLVSAIGALTSALPRTQRFNPTDIVLPIDSLSRTYPLCMTMAALFANSSIALNSVAGEDVDFALATAGVSPTVIIASSQTMAEYHDNIMRPHTGIISSLGRWLQARTLDAGNMPTRNVFSQLARVSPTSELSLDELRLLCISHRIDGDPAVHLTSEQLTDLRIFTGARLVYALTGPGVAGAIAQTNAFDYRCLPGPSHFGAPLSSTEITLTNIPEDSPYGTEEGQITVSGPAVVGGTVTLPERGHISKDNTLELSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W6QR00</accession>
    <name>W6QR00_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S05g000332</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QR00"/>
    <dbReference type="OMA" id="FFANFDE"/>
    <dbReference type="OrthoDB" id="4354024at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM36499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="226" mass="26114" checksum="89B4B5ABD31B583A" modified="2014-04-16" version="1">MSHPGNNLFLFVRNLDQGTREHLGHNTNTGPAHLTPEPCSSIPTESQAPAIMSLVEDFYFPFPRTSFRAAETTLIVQQVWFLGSKYLKRAIKRQHKLNDRTTFLISSCQALRKYRYLPWGKRRALAKNRRLRNYAHRMAGELADCDLAMLSLLAWHFSSKMVPLPQGLLQFFANFDEQFDTVCRSIHLSYTKMCEPDTLANFKERLRGLLRLLERHVIIGDGVLYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W6QR68</accession>
    <name>W6QR68_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Zinc finger, C2H2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PROQFM164_S02g002193</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QR68"/>
    <dbReference type="STRING" id="1365484.W6QR68"/>
    <dbReference type="OMA" id="DCEPCNR"/>
    <dbReference type="OrthoDB" id="6105938at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022755">
        <property type="entry name" value="Znf_C2H2_jaz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38846">
        <property type="entry name" value="C3H1-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38846:SF1">
        <property type="entry name" value="C3H1-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13894">
        <property type="entry name" value="zf-C2H2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12171">
        <property type="entry name" value="zf-C2H2_jaz"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="31"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="60"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="89"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDM32042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="284" mass="33086" checksum="54A90E2DD06DD6B3" modified="2014-04-16" version="1">MECCKLCDRSFSDRQAFQQHMRDAPVHTLTFRCDPCNRTFVSQSALDQHLRDSPVHIITYDCEPCSRSFVSQSALDQHVQNSPAHAVSFNCELCNRSFGSQDALDQHIQYSKAHIAPTSTPLDKFFRSFPRFRYNPKLPPSESYAQLREFCGWEKENPDGEKAWKKYQSALEAEVKMWFGAEDDLDAWHSLCRAIGIEPLPETCKQAVRVIRGVFVNIIDLIDWARSGSTTNRVQRFSSLEQLRKYTKQTGKVFHNRLDEDDDGNVVLRHLLRFLFNTNRRYYY</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2018-06-20" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W6QRI9</accession>
    <name>IFGF1_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Festuclavine synthase I</fullName>
            <ecNumber evidence="1">1.5.1.44</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Festuclavine dehydrogenase ifgF1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Isofumigaclavine biosynthesis cluster A protein F1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ifgF1</name>
        <name type="ORF">PROQFM164_S05g000507</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>FM164</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2017" name="Appl. Microbiol. Biotechnol." volume="101" first="6111" last="6121">
            <title>Silencing of a second dimethylallyltryptophan synthase of Penicillium roqueforti reveals a novel clavine alkaloid gene cluster.</title>
            <authorList>
                <person name="Fernandez-Bodega A."/>
                <person name="Alvarez-Alvarez R."/>
                <person name="Liras P."/>
                <person name="Martin J.F."/>
            </authorList>
            <dbReference type="PubMed" id="28620689"/>
            <dbReference type="DOI" id="10.1007/s00253-017-8366-6"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>PATHWAY</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2017" name="Org. Biomol. Chem." volume="15" first="8059" last="8071">
            <title>A bifunctional old yellow enzyme from Penicillium roqueforti is involved in ergot alkaloid biosynthesis.</title>
            <authorList>
                <person name="Gerhards N."/>
                <person name="Li S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28902217"/>
            <dbReference type="DOI" id="10.1039/c7ob02095c"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <comment type="function">
        <text evidence="2 3">Festuclavine synthase; part of the gene cluster that mediates the biosynthesis of isofumigaclavines, fungal ergot alkaloids (PubMed:28620689). The tryptophan dimethylallyltransferase ifgA catalyzes the first step of ergot alkaloid biosynthesis by condensing dimethylallyl diphosphate (DMAP) and tryptophan to form 4-dimethylallyl-L-tryptophan (PubMed:28620689). The second step is catalyzed by the methyltransferase ifgB that methylates 4-dimethylallyl-L-tryptophan in the presence of S-adenosyl-L-methionine, resulting in the formation of N-methyl-dimethylallyl-L-tryptophan (PubMed:28620689). The catalase ifgD and the FAD-dependent oxidoreductase ifgC then transform N-methyl-dimethylallyl-L-tryptophan to chanoclavine-I which is further oxidized by ifgE in the presence of NAD(+), resulting in the formation of chanoclavine-I aldehyde (PubMed:28902217). The chanoclavine-I aldehyde reductases ifgG and/or fgaOx3 reduce chanoclavine-I aldehyde to dihydrochanoclavine-I aldehyde that spontaneously dehydrates to form 6,8-dimethyl-6,7-didehydroergoline (PubMed:28620689, PubMed:28902217). The festuclavine dehydrogenases ifgF1 and/or ifgF2 then catalyze the reduction of 6,8-dimethyl-6,7-didehydroergoline to form festuclavine (PubMed:28620689). Hydrolysis of festuclavine by a yet undetermined cytochrome P450 monooxygenase (called ifgH) then leads to the formation of isofumigaclavine B which is in turn acetylated by ifgI to isofumigaclavine A (PubMed:28620689). Penicillium roqueforti has interestingly at least two sets of genes for the consumption of chanoclavine-I aldehyde on three different loci, the OYEs ifgG/fgaOx3 and the festuclavine synthase homologs ifgF1/ifgF2 (PubMed:28620689, PubMed:28902217). The reason for the duplication of these genes is unclear, probably to ensure the conversion of chanoclavine-I aldehyde by differential gene expression under various environmental conditions (PubMed:28902217).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>festuclavine + NAD(+) = 6,8-dimethyl-6,7-didehydroergoline + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:34055"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65034"/>
            <dbReference type="ChEBI" id="CHEBI:65045"/>
            <dbReference type="EC" id="1.5.1.44"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Alkaloid biosynthesis; ergot alkaloid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the fgaFS/easG family.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.44" evidence="1"/>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QRI9"/>
    <dbReference type="SMR" id="W6QRI9"/>
    <dbReference type="STRING" id="1365484.W6QRI9"/>
    <dbReference type="OMA" id="REDAPNT"/>
    <dbReference type="OrthoDB" id="9997102at2759"/>
    <dbReference type="UniPathway" id="UPA00327"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035835">
        <property type="term" value="P:indole alkaloid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051604">
        <property type="entry name" value="Ergot_Alk_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019901">
        <property type="entry name" value="Ergot_alkaloid_biosynthesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03649">
        <property type="entry name" value="ergot_EASG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43162">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43162:SF1">
        <property type="entry name" value="PRESTALK A DIFFERENTIATION PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0017">Alkaloid metabolism</keyword>
    <keyword id="KW-0520">NAD</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000444543" description="Festuclavine synthase I">
        <location>
            <begin position="1"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="Q4WZ69"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="28620689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="28902217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="4">
        <source>
            <dbReference type="PubMed" id="28620689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <evidence type="ECO:0000305" key="6">
        <source>
            <dbReference type="PubMed" id="28620689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM36674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="287" mass="31612" checksum="10C7A2D5C8DEDA65" modified="2014-04-16" version="1">MTILVLGGRGKTASRLAALLDAAKTPFLVGSSSTSQESPYNSSHFNWYEKTTWDNPFAEIGKHGLQPISAVYLVGPPTMDMVPPMIQFVDLACSKGVQRFVLVSASNIEKGDHSMGQVHAYLDSLPGVEYVALRPTWFMENLLEDPQRTWIKNESQVVSATGEGKIPFISADDIASVAFHCLTEWGSHKTEYIIQGPELLSYGQVAEILTSILGKKITHRSLSEAEYTNILVDEIGMPADFAAMSAAMEVDVKNSPQETLNGSVEEVTGNPPRFFRTFAEHEKQKWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W6QSF1</accession>
    <name>W6QSF1_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PROQFM164_S05g000872</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SOS response-associated peptidase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM37039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QSF1"/>
    <dbReference type="STRING" id="1365484.W6QSF1"/>
    <dbReference type="OMA" id="TPDCETH"/>
    <dbReference type="OrthoDB" id="2111841at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106300">
        <property type="term" value="P:protein-DNA covalent cross-linking repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1680.10">
        <property type="entry name" value="SOS response associated peptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003738">
        <property type="entry name" value="SRAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036590">
        <property type="entry name" value="SRAP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13604:SF0">
        <property type="entry name" value="ABASIC SITE PROCESSING PROTEIN HMCES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13604">
        <property type="entry name" value="DC12-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02586">
        <property type="entry name" value="SRAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143081">
        <property type="entry name" value="BB1717-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0190">Covalent protein-DNA linkage</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="56"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM37039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="192" mass="22040" checksum="524A328FE97E6D1F" modified="2014-04-16" version="1">MCGRYALGVRLAYIQQQLQEHGMQVDEAPDDDSVRETYNFAPGNFGAVYRAEITDKKSQQDVDSAHQNHDLEKGKDDASSDAKSVDNTIIKHKLQSMKWGLIPFWTKRQPDYGSMMRTINCRDDSLIDDSGIWTTMKRRKRCIVVCQGFYEWLKKGPGGKEKVPHFIRRKDGELMCFAGLWDCVSYEGMPSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W6QSV7</accession>
    <name>W6QSV7_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S02g002733</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QSV7"/>
    <dbReference type="STRING" id="1365484.W6QSV7"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM32582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="422" mass="48366" checksum="D88BE87A21DB459F" modified="2014-04-16" version="1">MLTPTRLQQEVKRPRRQLTISNKVIPAPLQVVIVLTNSQHIIEAFAQEYTQLQKLNTRTVTILDLHPRHGLSDSVVFQPLYLKEDFDNLIASAFLIDAYPPQMLRSTTTYLVCLSRPLEHILPYKHAIYDTYIVIFGKPSCLREYHFEVTQCPICEERSDITFTLAFNLTTDSFYNSEGLSKILKAAVNLSCCIFDIATANPTGCRIAIIVSCISNSKAYILANYRGISPRSTNTAYEFLTLYNNRQDPSLLNAVYTNTLLGITLRESSIIWPMAKRHDLLLSIGTGFSISPPSRPTDRKQGFLEALNYLPYLLTPNIFRLDQVIDRTLPRLDNIYSLEAMLDIDFTVPAELIRTILALVIFFFKLDKTPIQGSIDLVDIYRFYRYFRKRINFWVTSLNEMVTIEIANNTFRERISGFPKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W6QVL0</accession>
    <name>W6QVL0_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S09g000075</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792023">
        <property type="protein sequence ID" value="CDM38159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QVL0"/>
    <dbReference type="OMA" id="KISYTHW"/>
    <dbReference type="OrthoDB" id="5366688at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="17"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM38159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="191" mass="20545" checksum="EAC618D37710A403" modified="2014-04-16" version="1">MSPRYGALGATFQLSRLFQVCSLIAIIGMTAKFISVIVNNNATPPNILIGTISVTCIAAIYCIITAILYTDDILPFLACAVLDTLLLIALIVVTVIVGKPLSYLKCTTLAELGDKDATLYAFASRLSSYIASVSGKIDYVSWIGASKAICIETKAIWGLSIGLCILFFFSVICNVCLWLQKKKALAVKSME</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W6QW90</accession>
    <name>W6QW90_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cell wall beta-glucan synthesis</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S03g000476</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QW90"/>
    <dbReference type="OMA" id="ITWQAKP"/>
    <dbReference type="OrthoDB" id="4094614at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018466">
        <property type="entry name" value="Kre9/Knh1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052982">
        <property type="entry name" value="SRP1/TIP1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40633:SF1">
        <property type="entry name" value="GPI ANCHORED SERINE-THREONINE RICH PROTEIN (AFU_ORTHOLOGUE AFUA_1G03630)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40633">
        <property type="entry name" value="MATRIX PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G05410)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10342">
        <property type="entry name" value="Kre9_KNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004879913" evidence="2">
        <location>
            <begin position="19"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal" evidence="3">
        <location>
            <begin position="36"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM33752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="253" mass="25690" checksum="71EA34F846F6D214" modified="2014-04-16" version="1">MRFTIATAFSAFVALAAAYTAPDYNQQPSGNAITYPGLNEIVPEGKAYTIKWTPTTVGPISLILLRGPSTNVLPLETLAESIPNSGEFSWTPSADLEADVTHYGLLLVVEGTGQYQYSTQFGISAAVVSSSSAVASSTTETTASASTPVAASTVIESTEITTTICPETETTAAATTAATTVATTFATTPAPKVTPTGVSPVKPPTSTPLTSIRLTTSAVPTASPSATPVFNSAGRNAISFGAVMAGVIAAFAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W6QWL2</accession>
    <name>W6QWL2_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S15g000013</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792029">
        <property type="protein sequence ID" value="CDM38549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QWL2"/>
    <dbReference type="OMA" id="KGDWAGH"/>
    <dbReference type="OrthoDB" id="2588098at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM38549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="162" mass="18403" checksum="7B8BE6F1BD072710" modified="2014-04-16" version="1">MPPGARERLGPRYGLYLISAESEVTPKPLRYDVAEENFEFWSYTEEGATFPAMEESVDPKDRILRNLTTNQYVLEARLPCGITAGHIALMRICWLSDSLTSITGGGYLAKGDWAGHKFDIIDADILENVNGEWEDVTEDICDEIQVLWSSNFGHNWETKWRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>W6QXA2</accession>
    <name>W6QXA2_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tripeptidyl-peptidase II</fullName>
            <ecNumber evidence="4">3.4.14.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">sed2</name>
        <name evidence="18" type="ORF">PROQFM164_S03g000906</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Secreted tripeptidyl-peptidase which degrades proteins at acidic pHs and is involved in virulence.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal tripeptide from a polypeptide.</text>
            <dbReference type="EC" id="3.4.14.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="15">Binds 1 Ca(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
            <location evidence="3">Extracellular space</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.4.14.10" evidence="4"/>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QXA2"/>
    <dbReference type="STRING" id="1365484.W6QXA2"/>
    <dbReference type="OMA" id="YARSVCN"/>
    <dbReference type="OrthoDB" id="409122at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008240">
        <property type="term" value="F:tripeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04056">
        <property type="entry name" value="Peptidases_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11377">
        <property type="entry name" value="Pro-peptidase_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.200:FF:000015">
        <property type="entry name" value="Tripeptidyl peptidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015366">
        <property type="entry name" value="S53_propep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030400">
        <property type="entry name" value="Sedolisin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050819">
        <property type="entry name" value="Tripeptidyl-peptidase_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14218">
        <property type="entry name" value="PROTEASE S8 TRIPEPTIDYL PEPTIDASE I CLN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14218:SF15">
        <property type="entry name" value="TRIPEPTIDYL-PEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09286">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00944">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51695">
        <property type="entry name" value="SEDOLISIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11 15" id="KW-0106">Calcium</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 15" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="10 15" id="KW-0720">Serine protease</keyword>
    <keyword evidence="8 16" id="KW-0732">Signal</keyword>
    <keyword evidence="12" id="KW-0843">Virulence</keyword>
    <keyword evidence="13" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004880551" description="tripeptidyl-peptidase II" evidence="16">
        <location>
            <begin position="26"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S53" evidence="17">
        <location>
            <begin position="211"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="15">
        <location>
            <position position="287"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="15">
        <location>
            <position position="291"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="15">
        <location>
            <position position="502"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="544"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="545"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="579"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="581"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CDM34182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="601" mass="65191" checksum="EEFAF31BBED62C44" modified="2014-04-16" version="1">MIASLFSRGALSLAVLSLLASSAAADVFESLSAVPQGWRYSRRPRADQPLKLQIALTQGDTAGFEEAVMEMSTPDHPSYGHHFTTHEEMKRMLQPSAESAESIRDWLEGAGITRIEQDADWMTFYTTVETANELLAANFQFYVSNVRHIERLRTLKYSVPKALVPHINMIQPTTRFGQLRAHRGILHGQVKESDEAFRSNAVSAQPDCNSIITPQCLKDIYNIGDYQANDTNGNKVGFASYLEEYARYSDLALFEKNIAPSAKGQNFSVTRYNGGLNDQSSSGSSSEANLDLQYIVGVSSPVPVTEFSVGGRGELVPDLDQPDPNDNNNEPYLEFLQNVLKLDKKDLPQVISTSYGEDEQSIPEKYARSVCNLYSQLGSRGVSVIFSSGDSGVGSACLTNDGRNATRFPPQFPAACPWVTSVGATTHTAPEQAVYFSSGGFSDLWARPKWQEEAVSEYLEILGNRWSGLFNPKGRAFPDVTAQGRNYAIYDKGSLTSVDGTSCSAPAFAGVVALLNDARLKVNKPPMGFLNPWLYSTGRAGLKDIVDGGSTGCDGKSRFGGANNGGPSIPGASWNATKGWDPVSGLGSPNFATMRKLANAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W6QY16</accession>
    <name>W6QY16_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Transcription factor, fungi</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PROQFM164_S03g001161</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QY16"/>
    <dbReference type="STRING" id="1365484.W6QY16"/>
    <dbReference type="OMA" id="RYCREPD"/>
    <dbReference type="OrthoDB" id="654211at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002123">
        <property type="entry name" value="C2H2 transcription factor, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002991">
        <property type="entry name" value="C2H2 transcription factor, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF25">
        <property type="entry name" value="TRANSCRIPTION FACTOR, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G02070)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="7"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="35"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="57"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="191"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="64"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDM34437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="759" mass="84821" checksum="C34CB1D1DDB268E4" modified="2014-04-16" version="1">MLNSKPYQCQRCPRAFARLEHLQRHDRSHTKEKPFVCVQCPKAFTRKDLLARHERLSHNPDASPASNNTHTPSPANPSPLDGLNSLASVVNHAQSNPSALQGPVDHFTSLSPAVHRPVLGTQLASIDTPSERPTTPSPGPDFGYALSGFGPASYQAHDFTSFLDSVPLPNHPFSPAYQPLPLFPPLHFSPVPEYDQSSDRGALTENTPSTPSSSVLPRNDTQLPSLQPEGYHHISPAARQPTGFVPVTAECREKFMNMLADYANVVPDPSMPSRHALSRCLTGYVTGFHEHYPIVHIPTFDVDSMTLPYFLAMAALGARYCREPDTAFRLYQIAKPVTMEHVRRVFQSGKLPPPGLNAADDIGTLQTVQALLYMTSVSLWFINNPPYHEALSLRSLMEIVVRQGGLNRLPEQDGTWSSWIRRECVKRTKLIVFCFFNIHTIVFDVPPMILTEDFTLELPSTEKEWQAPRSDLWQIERMKSPGEPKFQDALSALFKPTSNVERFSSLGGYVLIHAILQDIWLMTKAGRLPVSRRNRFTPSSMAPTPELVHVEQALERWCQCWERNQESSVDPLSPNGPLSFTSAALLRLAYIRLNADCGSARQLQTWDPVQIATSLHDNLAVRRGDRLTRAALHCAHALSTPVKLGIGFVAHSQVALWSNQHALCSLECAVLLAKWLEAITVPDPDPGLTEQETRLRDFVLEMVMEVEHGVSREWLLATNTRLSAAVTRLWARLFTADYIWEMVSLIGKSLNSYADLLEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W6QZ39</accession>
    <name>W6QZ39_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S03</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S03g001519</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QZ39"/>
    <dbReference type="STRING" id="1365484.W6QZ39"/>
    <dbReference type="OrthoDB" id="4368902at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM34792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="237" mass="27384" checksum="BD64AD258166505E" modified="2014-04-16" version="1">MIRQGARNMFEETRLVPDAHYAKAPAHGKEQLRILHYGTRSFNIAVFVDIIIAEYRLREIVQQEKSLKRKVRVIEKIAADKYGDKAAQYYNQELTILLRQYSEAEYKLYLAEIMLPIGPSNGLENCMKRGGCCSRDCGCCHDRHERTERNKGIGHCTPTCDCCSRERGFNYTARERQGFVEDFKKKQYDNNPACVIQMVEAFFLLPVVGKPQVKTQGQPQPGQGGNKRLWKRIFRKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W6QZV2</accession>
    <name>W6QZV2_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glutamine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">GLN4</name>
        <name evidence="14" type="ORF">PROQFM164_S03g001824</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>tRNA(Gln) + L-glutamine + ATP = L-glutaminyl-tRNA(Gln) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:20121"/>
            <dbReference type="Rhea" id="RHEA-COMP:9662"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.18"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.18" evidence="2"/>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM35097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QZV2"/>
    <dbReference type="STRING" id="1365484.W6QZV2"/>
    <dbReference type="OMA" id="FAWRIMG"/>
    <dbReference type="OrthoDB" id="10250478at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004819">
        <property type="term" value="F:glutamine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006425">
        <property type="term" value="P:glutaminyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1160.10:FF:000001">
        <property type="entry name" value="Glutamine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.240.10:FF:000007">
        <property type="entry name" value="Glutamine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.240.10:FF:000015">
        <property type="entry name" value="Glutaminyl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000183">
        <property type="entry name" value="Glutaminyl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.240.10">
        <property type="entry name" value="Ribosomal Protein L25, Chain P"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004514">
        <property type="entry name" value="Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050132">
        <property type="entry name" value="Gln/Glu-tRNA_Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000924">
        <property type="entry name" value="Glu/Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020058">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020059">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_codon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020056">
        <property type="entry name" value="Rbsml_bL25/Gln-tRNA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011035">
        <property type="entry name" value="Ribosomal_bL25/Gln-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049437">
        <property type="entry name" value="tRNA-synt_1c_C2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00440">
        <property type="entry name" value="glnS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43097:SF4">
        <property type="entry name" value="GLUTAMINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43097">
        <property type="entry name" value="GLUTAMINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00749">
        <property type="entry name" value="tRNA-synt_1c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03950">
        <property type="entry name" value="tRNA-synt_1c_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20974">
        <property type="entry name" value="tRNA-synt_1c_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00987">
        <property type="entry name" value="TRNASYNTHGLU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50715">
        <property type="entry name" value="Ribosomal protein L25-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9 14" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic" evidence="11">
        <location>
            <begin position="94"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamyl/glutaminyl-tRNA synthetase class Ib anti-codon binding" evidence="12">
        <location>
            <begin position="414"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA synthetases class I (E and Q) anti-codon binding" evidence="13">
        <location>
            <begin position="528"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="8"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="45"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF03950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF20974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDM35097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="647" mass="73253" checksum="D7FCE6EACFD685D9" modified="2014-04-16" version="1">MDPAKPVDLPERPKEATEPTDPPKKSKSQEKKEAAAAKKAAAKLARQDQPKSKGEPKAPKAKDAPAPRDPEAMFKVGFLHDVYQEKPLSETVPKIRTRFPPEPNGYLHIGHSKAIAINFGFAKYHGGECILRFDDTNPEGEEERYYNAIREIVTWLGFTPVRETNASDNFDRLYELAEDLIKRDGAYVCHCNKSEIKAQRGEIEGGQRGGERFSCSHRTRPIEESLSEFRAMRDGKYKAGEAALRMKQDITDPNPQMWDLFAWRIMGSEDKQHHLTGGKWKIYPTYDFAHCLCDSIEEISHSLCTTEFELSRVSYEWLCDKLEVYRPNQREYGRLNITGTVLSKRKIIQLVKEGHVRDWDDPRLYTLIALRRRGVPPGAILSFVNDLGVTKNTTNVQVTKFEQIVRQYLETTVPRLMVVLEPLKVIIDDLPEDHLELIDCPFSKDPAFGTHNIPFTKTVYIERSDFRAVDSPDYFRLAPGKTVGLLKVPYPITATSFETDPATGEVTCVHAKYEKPAEGEAPTKPKSFIHWIGESAAHNSPVRAEVRAFNSLFKSEDPSAHPAGFLADINPDSEEIFKDAMVETGIRDISRSAPWPKEEGAAEPGEHKHSIRFQGMRVAYFAVDRESTDEKLVLNRIVTLKDTQGKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W6R0Y6</accession>
    <name>W6R0Y6_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ENTH/VHS</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S04g000373</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6R0Y6"/>
    <dbReference type="STRING" id="1365484.W6R0Y6"/>
    <dbReference type="OMA" id="LWMQRLK"/>
    <dbReference type="OrthoDB" id="10069473at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099122">
        <property type="term" value="F:RNA polymerase II C-terminal domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17003">
        <property type="entry name" value="CID_Rtt103"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000030">
        <property type="entry name" value="DUF618 domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006569">
        <property type="entry name" value="CID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047883">
        <property type="entry name" value="Rtt103-like_CID"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12460:SF0">
        <property type="entry name" value="CID DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12460">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE INHIBITOR-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04818">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00582">
        <property type="entry name" value="RPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51391">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CID" evidence="2">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="277"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="344"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM35492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="418" mass="45666" checksum="340BCCBB6F4354A5" modified="2014-04-16" version="1">MAFTDDAVKAKLSALNDTQESIVTVAQWVMFHRRHAERTGQIWLQKIRDSPPPKRLNLIYLANEVAQQSKVRGKNDFLIALSPIIVDATSAAYKGSSNEYQQRIRRVVEVWRQRNVFDGVILDAVEARIDELDKARPTNKKQTLGGSFFKDTSSGSSPSELQPLNPLQVALNKAVINSHNSATTATSEFDKLHDPKTPKATLPVHAARLSSLLKTLANAENSLSEVIKSRRALIDGLEKILQTNRAELSKEEAISAELSQKKASADTKKREVEDAIMRGLPSEESSTNPGEYNGHDDAPARPTVEALTPPPVEAITPVGSPQPGKQQLRRGPFTEEADDDVSEWNPTNTANMQQSGNGTAVSDQPTTISPNHGNDFDVAADVHAKRRKISHGEEDYAAFAAGDLDSDVADLLATQGNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W6R2N7</accession>
    <name>W6R2N7_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Dynamin, GTPase domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S04g000978</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM36097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6R2N7"/>
    <dbReference type="STRING" id="1365484.W6R2N7"/>
    <dbReference type="OMA" id="YSAFCRN"/>
    <dbReference type="OrthoDB" id="3598281at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00882">
        <property type="entry name" value="Ras_like_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056024">
        <property type="entry name" value="DUF7605"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36681">
        <property type="entry name" value="NUCLEAR GTPASE, GERMINAL CENTER-ASSOCIATED, TANDEM DUPLICATE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36681:SF3">
        <property type="entry name" value="NUCLEAR GTPASE, GERMINAL CENTER-ASSOCIATED, TANDEM DUPLICATE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24564">
        <property type="entry name" value="DUF7605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin N-terminal" evidence="2">
        <location>
            <begin position="237"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7605" evidence="3">
        <location>
            <begin position="727"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM36097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="993" mass="111237" checksum="BE729B70E962560C" modified="2014-04-16" version="1">MTEVPSSEFTFSVHSQSEVAFTPSSSRDTNRSGGPALTPQTPRLVPIFGNLGLNDSLAPMHSPPTWSSNAWLRPGSSHSNYAQQHNASPSPSPRPELVRTINGSQQHEKTSSISSSSTRATPRIPGAFPTSSTGQAAPPTESDRVQDDEESDSDHCSDVEEMTEAKSAGVREEPLPTAPIYSRRVQDGLKEVKCELAALADIMGLSELNQDHSSDLHVLYKRTKKMSMFEYPETRTVGFIGDSGVGKSSLINSLLDQESLSRSSREGTACTCVVTEFRHVDENHTGPFTIEADFMTSEEMKGLLGELLTIFRQFHVTRFFQELKSQEEQQKCRDQAGRAWGTFQSLFNKQPGLTMEHLSQDFEDAYLVLLSQLERWASASLALRPGGLDALEYSVVAGDIEECRDILDMLTASNAGNGNPAIWPFIKLIRVYLKSPILRNGLVLADLPGFSDLNFARVRATERYLSHSCDEVFVVMDISRACTNASVQDIMRRCRDDQPRRIICTKSEDISPEESSRGDTPYAHRVKEMNKEMQVLRKKLESTESKARKASPARRSELAVKAMELRGQEKVLKFNMSQFLINRRNSLISHELIQRHQDVEVFCVSNILYSEYRFSGKSDEEAYVDLAGIRELRRYCQLVPAAALMRSTSAFLNHEVPALLSSLRQWALSGVDPVTGGNAALLRRVLENAQNSFHRELISDQGLAQITRRSLIGLYDECITNIIRQYQSRWTAESIQISLEWAGWSHSTYSAFCSHYGDHTTGAVPNGRCWNDDLLQPSREQLTLKWENIQTSLHLQEGSLARYTDTIFDKWCLQFGAHIQLAPCALANLQQSMKFRQQCIGHHISNTLLKVIQCAENIKRDTIYGHASSYISGLMQPAYARINQEGGTGSEKRRKKIMNDHLTHSMLFANISRLAGREYIGALDACFDDLQTKVTEEVESMARDFNAVIADEGQLSEAEKAPAVANALESRFERTKDILERAQIIVRELNPDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W6R510</accession>
    <name>W6R510_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S05g000745</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6R510"/>
    <dbReference type="STRING" id="1365484.W6R510"/>
    <dbReference type="OrthoDB" id="4369470at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM36912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="188" mass="20667" checksum="5D49C17A90DA40B8" modified="2014-04-16" version="1">MAEAPLCIQNEIDKNGEWVPPPRGVKLSDEGVYLAVKNMSAVERGERFPVDFDKNGHVRATCIPEDPAPLGWAHDLPMIMVAQGIIPLVGQLHARKLGNLTLKTDANIKNSPAFTVGPVVASKSVVEMSRSIQRQYVTHKPDRGYKMEYNLDTAVDVVSNDHQDMAILLGDCHTGAQSRLPSSRPFKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W6R5Z6</accession>
    <name>W6R5Z6_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S06g000193</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792020">
        <property type="protein sequence ID" value="CDM37232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6R5Z6"/>
    <dbReference type="STRING" id="1365484.W6R5Z6"/>
    <dbReference type="OMA" id="GVQMSVH"/>
    <dbReference type="OrthoDB" id="429143at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847:SF279">
        <property type="entry name" value="FAD DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847">
        <property type="entry name" value="SARCOSINE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="1">
        <location>
            <begin position="43"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM37232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="454" mass="49848" checksum="53D2C33F8F2C48EF" modified="2014-04-16" version="1">MSSNSNEKCFPRPAAGYTQSFWRTQPDPLDNHQTTTELPKEADILIIGGGYVGASAAYRLLAENPQNPAPRVVLVEARELCSGATGRNGGHLRPDIYSATALFTERYGIEAAAEIVRFEISHLKIMEELVRKENIDCELTFTRSYDMYLDEDQLKKAKAFYDFLVDQGLDFMNDVKYLSQAETQDIAHVRDAKGGFSFPTGHLWPYKLVSHLIRIAVSHGLNLQTNTPVSEIGETPNADGSWPVTTSRGVINARKIILATNAFTSALAPEYSKAIIPCKGICSQIAAAPGAPHQELPGTYCIRIGPEGYIYQISRNDGSLIVGGASHLFKDDREEWYNNPDDGKLIKVAADYFDGYMQRTFLGWEDSRAEIKHIWAGVMGYSADSLPHVGSIPGKPGQFIAAGFNGHGMPVAFLSGRAVADMAQSSVTFEDTGLPRLYKTSLARLEPVFDDILG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W6R6S8</accession>
    <name>W6R6S8_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Mediator of RNA polymerase II transcription subunit 6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">Mediator complex subunit 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">med6</name>
        <name evidence="11" type="synonym">MED6</name>
        <name evidence="13" type="ORF">PROQFM164_S06g000504</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 11">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 11">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the Mediator complex subunit 6 family.</text>
    </comment>
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    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="GO" id="GO:0006357">
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    </dbReference>
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        <property type="entry name" value="Mediator complex, subunit Med6"/>
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    </dbReference>
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        <property type="entry name" value="Mediator_Med6"/>
    </dbReference>
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        <property type="entry name" value="Mediator_Med6_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13104">
        <property type="entry name" value="MED-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04934">
        <property type="entry name" value="Med6"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="8 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 11" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="177"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="275"/>
            <end position="339"/>
        </location>
    </feature>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="318"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="330"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00025687"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00031259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU364143"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CDM37542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="339" mass="36477" checksum="3411A17912002852" modified="2014-04-16" version="1">MANQDASMEEILWRSPPHVQMMGGFLHSNNILFYFAESPFFDATSNNASLAIQANYNDAFRHFVETREAFEARLKTMQGLEFIVSYDPLQAAAQTDTRFAHEPSNIWVIRKQNRRKRSGMDDEVTVIATYFIVGDCIYMAPSVASVVGNRILSAVTSLTQLMKSAATLPTFTASHGHTYLPPGVRSKEPAGTSQAPQSKEATPMPDVSFPATESSQSTSKSGLGGSSTGSKYQDTRSLAESFSLLTRYGDEFMDESPLVGEPGSFILSRTGGEATASAVKGAPKTAANLAPTSTPSTLPVRASTPQVRVETPGKASDKSNSPPSSTSDKGKRKKARIVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2024-10-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W6R8J4</accession>
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        <submittedName>
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        </submittedName>
    </protein>
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    </gene>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
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                <person name="Sallet E."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792023">
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        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002909">
        <property type="entry name" value="IPT_dom"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IPT/TIG" evidence="1">
        <location>
            <begin position="3"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM38182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="105" mass="10523" checksum="9C8AD69BE64569EE" modified="2014-04-16" version="1">MSLPTISRINPTSGPTTGGITAIISGTNLAGATTVTFGTVTAVPTSSTATTVSVVVPANTAGTVRVSVTTPNGTSTSIVNFTYAPIRTGFSLAYGDFLFDLPPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W6R9A7</accession>
    <name>W6R9A7_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S12g000051</name>
    </gene>
    <organism evidence="2 3">
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">FM164</strain>
        </source>
    </reference>
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    </dbReference>
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        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="32"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM38442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="49" mass="5598" checksum="552AD00B79A28718" modified="2014-04-16" version="1">MWLMHFPKLRGNYPWLINKVFLVKEKREEPFSGVSSGSSPGSSSGPLYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W6R9N5</accession>
    <name>W6R9N5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidoglycan-binding lysin domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S20g000009</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792034">
        <property type="protein sequence ID" value="CDM38582.1"/>
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    <dbReference type="STRING" id="1365484.W6R9N5"/>
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    <dbReference type="OrthoDB" id="5985073at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="LysM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052210">
        <property type="entry name" value="LysM1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34997">
        <property type="entry name" value="AM15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34997:SF1">
        <property type="entry name" value="PEPTIDOGLYCAN-BINDING LYSIN DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="LysM"/>
        <property type="match status" value="5"/>
    </dbReference>
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        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="LYSM"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0843">Virulence</keyword>
    <feature type="domain" description="LysM" evidence="3">
        <location>
            <begin position="275"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="3">
        <location>
            <begin position="361"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="3">
        <location>
            <begin position="554"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="3">
        <location>
            <begin position="642"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="3">
        <location>
            <begin position="726"/>
            <end position="772"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM38582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="776" mass="82821" checksum="AE26655A1F66B6A3" modified="2014-04-16" version="1">MLLADTATMSVPTGFFNISDLTMFSSDCAAALASTVDCSDIIRDSDFQSGLSAENITALCTIACFDSITSFRSKVLTSCANDVYTDEPVNGTSYVYGTGVKDDIYNIEGISIKPIGLVDPFFVNYNVTCMQDDANPPAFCYLSPVNGTTGEPESDPCGNCGLGIMRAQLDNAVGWIDRLASQYLSSASSCGVTVPPLAEPTPVFLSNSKTMVSNTSTTLTCTGSYVPVPTGSTCDEFAEANSVATDQLLMVNGLLGGCTNWPGNLTSLCVQATCQPYLVRRNDTCISVSRAHKITLTQLLSWNPTIDPVCANWPTKIDHVICVGNNVGYVKPSTSFEASTTATAVSIPTNAVDGSNAKCAKWYSVGNNDNCASITVQNGISLDDFEFLNPELNANCTNLFLDYSYCVQAVGDIATYSGYATTTTKYASLTADPAITWANLPTATRPVYNLTTTTSSYPLASGSLDGCFATFNNNMGALGCWEAASIFGVSVTNFLLWNPSILNGQNYTIYNCKLTNETRYCGSFYNQTLASTSTMVWASVPTDAPANSTTECLDWYETVDGDDCDSICRSYDIPFTSLYEWNPSVGSDCTNLWMNTPYCVMGHGWSTVSYNMSTTSSSTSATSSTGAPPAPTQSGIVAHCLEWYVAQTNDSCTAIASAYSITLAQFNAWNPAVGENCAGLWVDEAYCVKAPTTAITTHSTAVTTSTRATMTPPAPTQAGIPSECNAYDVAQHGDGCEVFASRNNITVDQLYTWNPALNNVCENFWLNEAYCIGVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W6PQU6</accession>
    <name>W6PQU6_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein family UPF0136, Transmembrane</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PROQFM164_S01g000382</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM14 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PQU6"/>
    <dbReference type="OMA" id="YGLFTFG"/>
    <dbReference type="OrthoDB" id="5620at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1740">
        <property type="entry name" value="Transmembrane protein 14-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005349">
        <property type="entry name" value="TMEM14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044890">
        <property type="entry name" value="TMEM14_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03647">
        <property type="entry name" value="Tmemb_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="59"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM26573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="107" mass="10932" checksum="73B509338460D79E" modified="2014-04-16" version="1">MASPTSSALALSLLTSVGGIIGYTRTGSIPSIAAGVSVGLVYLFAFLRLRASQTYGEELGLLASAVLGGSSIPRVIKTGGKPVPLVLSVLATYGLFVFGVAFREKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W6PR00</accession>
    <name>W6PR00_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Probable transposable element</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S01g000432</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PR00"/>
    <dbReference type="STRING" id="1365484.W6PR00"/>
    <dbReference type="OMA" id="CSINHIT"/>
    <dbReference type="OrthoDB" id="4354814at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE-1" evidence="2">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM26623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="116" mass="13140" checksum="80BE745EC7C1877D" modified="2014-04-16" version="1">MPLHLSYLLQPLDIGCFAVVKRSYGRLVEIKMRTGINHIDKLEFLEAYPSVRIEALKLETIKNSFLAAGLIPFSPNRVLSKLNIHLRIPTPPPSRGSDSSRNFTPKTPFNGKDLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W6PRP0</accession>
    <name>W6PRP0_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PROQFM164_S01g000667</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PRP0"/>
    <dbReference type="STRING" id="1365484.W6PRP0"/>
    <dbReference type="OrthoDB" id="3945418at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF157">
        <property type="entry name" value="N-ACETYLTRYPTOPHAN 6-HYDROXYLASE IVOC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM26858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="178" mass="20963" checksum="0F6CAD28813961E8" modified="2014-04-16" version="1">MKKRAVLFICLCANLSHLLAFRTTAFIAYWISVYIYRVTLHPLAKFPGPKLTGATFWYKFYYNLFPHKLRFLWKIEDLYNQYGPIVRINPLHIHIRDPEYLDDIYTSGRRKRNRNDKRSIQALEDRVVDKIDILVDRIAEARQTGETVNLLFAAGTLTIYIISAYTFGKDWNKLGEPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W6PRT5</accession>
    <name>W6PRT5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type DNA-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PROQFM164_S01g000389</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PRT5"/>
    <dbReference type="STRING" id="1365484.W6PRT5"/>
    <dbReference type="OMA" id="ARACFAN"/>
    <dbReference type="OrthoDB" id="5425448at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052973">
        <property type="entry name" value="Fungal_sec-metab_reg_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35392:SF4">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35392">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="442"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="79"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="309"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="341"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="97"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="312"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="345"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDM26580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="795" mass="88644" checksum="AD30ECF1862B9CE4" modified="2014-04-16" version="1">MDCRSTGTAAGIDPKILDNWQTEGTFSVASWEHLGYDQSPEWDTSQDSSQCDADIADLGTFHGPLAGEFRRLENRKHDVSPENLNYPDGLVEGTGSGTLSPKTIPSSTDENYHSDEAWPQFQLYNPVAMPMDAPLLYPYAKGPDHSNGAVIVDDVEEMPHSGYSDVPAEGIMSFQQIPQSFPMIPEEWSVIPHDIPVENMPLPQEPMLLSVDTQGNPKDHSLRGYQTSVRSLESRWLNSLASQVPAQQITSVSPTAGPRNAQMGQEFQFKSENSSVSGDMSAIYECSYSATSDDADAPAFAERQMEDDDFQWKTSSHESTSPEGSQPAFKPTAFVVSEAPAESLVSTVPSRPRTSSTAGQRANRPAPLAMQSSATVKKRKTKNPASMDHGITRPLQIVQEDGQGGSIASADFVSPPRGARRKGPLSMVGRANAGLRRKNKDTCVQCRLNKRKCDGSAPCDACRPTLHEQPCARACFSSIVEFGTCNYISQRAVNHPTVDGSNRVRMEIPSEFDLSQLVSLLAERQGRFNIRASQAWGSLYVLDLGETYKFLKTLSEYNGNSKSTFLEFIDRRIVDSKDKSKNWLSCVADCDPMNQAYTLLSQWNNMPSRAKYSFVSLDPTAEERTMDINNPEDQREILLAAQLSRIFCRMLEVEGFRKLERDFYNIKWKQISHETHVRFLGELGHILLTLRWRVSWWKRLGDGGHNPDPTSQHYIDRVELLCRILYVYYTCVLAKLPSWSAADVPKGIWSTYADSENAIWDDFPSDSSDGGFNGWMERGQELIEQAGVPSRISKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W6PSK5</accession>
    <name>W6PSK5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PROQFM164_S01g000639</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PSK5"/>
    <dbReference type="STRING" id="1365484.W6PSK5"/>
    <dbReference type="OMA" id="ILYAWNL"/>
    <dbReference type="OrthoDB" id="10017208at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF151">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="123"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="197"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="29"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="287"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="287"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="310"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="371"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM26830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="382" mass="43268" checksum="B2F832B325ABA9E9" modified="2014-04-16" version="1">MESNQDSLQPWSVATTASVTVLAFVTVCLRLLARYERMQKLWWDDYMVIFSMLWNFIVVGFIYAMIHKGMGLHADTIPVENVIMIAKFLVVAEVLYVYNLVWTKLSILLMYYRIFRFPYFKTWAYVIGLFIILWVICITFLFIFICVPVQKLWYPQLPGRCIDQVATWVANAVSTIATDVAILFLPIPQVWKLQLRLSEKVAVLVAFSLGFFVVFASAYRFSVLFSYSSADSSYTLARTVGWTAIEMSAGIVSANLPTIRPALRFIARMLGISGTMMAIFRSTNRTNAKTTDAATQPSGTAESTSTIMQHNKHPKRHSFYHLPDDPNSPGEQPGMDTSFRPDYDQGKTYTNVLGPSAGDHSDGDEIPLTEIRVDKEFTQRVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>W6PT11</accession>
    <name>W6PT11_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="6">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PROQFM164_S01g001127</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12 6">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="6"/>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PT11"/>
    <dbReference type="STRING" id="1365484.W6PT11"/>
    <dbReference type="OMA" id="FKSDAEY"/>
    <dbReference type="OrthoDB" id="333239at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061136">
        <property type="term" value="P:regulation of proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02657">
        <property type="entry name" value="Peptidase_C19A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16104">
        <property type="entry name" value="Ubl_USP14_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044635">
        <property type="entry name" value="UBP14-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43982">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43982:SF1">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="3 6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="8">
        <location>
            <begin position="4"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="9">
        <location>
            <begin position="111"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="396"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="396"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="425"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDM27318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="575" mass="64286" checksum="50BFFE518020A8EA" modified="2014-04-16" version="1">MAAIPIIVKHAGKRHEVELDPTTNGETLKYQLFSLTGVEPDRQKVLVKGGQLKDDTPLSSLNAKPGQVFMMMGTPSGGQGSADLGRPKETVKFLEDMTEAEVARQKGARPAGLQNLGNTCYLNSSLQTLRSVPELQDELLRYRPSGGSGQSTLSDLSSFGIGGLGGSRDLAASLRDLFKQMSETQEGIPPLMFLNALRAVFPQFAQRDRNGQGYSQQDAEEAFSQILNQLRTKLTITEGEGESATTTSFVDKYLAGQFESITECEDPAAKELGEQPSQSSEVFYKLDCHIGKETNHLQDGILAGLEEEIEKNSPLLERNSMYKKRSRIARLPKYLTVHFVRFYWKRETKKKAKIMRKVTFPAELDVVEFCTEGLRKQLIPIRDKVREIRKEELEVERSQKRQRVAEERAERQAKETNLGENVEPMQKKAEETKAKANDKDGDSQMEETFKTDAEYEAEKAEAILAAKKELQELIKQQGAGDSGTNQSGLYELRAVITHQGASADSGHYTAYVKKQEQDDPQTGSKRREADDKWWWFNDDTVTEVDAQKIETLSGGGESHSALICLYRAIELPKCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>W6PT54</accession>
    <name>W6PT54_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 15">Aurora kinase</fullName>
            <ecNumber evidence="1 15">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">ark1</name>
        <name evidence="18" type="ORF">PROQFM164_S01g000735</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1 15"/>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PT54"/>
    <dbReference type="STRING" id="1365484.W6PT54"/>
    <dbReference type="OMA" id="ESRFPEW"/>
    <dbReference type="OrthoDB" id="377346at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032133">
        <property type="term" value="C:chromosome passenger complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051233">
        <property type="term" value="C:spindle midzone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008608">
        <property type="term" value="P:attachment of spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045143">
        <property type="term" value="P:homologous chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044779">
        <property type="term" value="P:meiotic spindle checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032465">
        <property type="term" value="P:regulation of cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090266">
        <property type="term" value="P:regulation of mitotic cell cycle spindle assembly checkpoint"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902115">
        <property type="term" value="P:regulation of organelle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072479">
        <property type="term" value="P:response to mitotic cell cycle spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000819">
        <property type="term" value="P:sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14007">
        <property type="entry name" value="STKc_Aurora"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000042">
        <property type="entry name" value="Aurora kinase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000235">
        <property type="entry name" value="Serine/threonine-protein kinase ark1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030616">
        <property type="entry name" value="Aur-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24350">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE IAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 15 18" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 11 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 14" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="112"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="70"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="84"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="235"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11 13">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="190"/>
            <end position="192"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="239"/>
            <end position="240"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="253"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)" evidence="12">
        <location>
            <position position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU367134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CDM26926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="388" mass="43904" checksum="A799856C7BA8E18F" modified="2014-04-16" version="1">MATTKTLEARFEHLSMKDEKENGNSDRSYGKQKVPVSSAQSNSNSNRAQLLKLALQNNNENKANAMNVAASPGKGSHGALVTRSTDENGDQRRSSSLCEQPTVAKELHLGMFEIGKPLGKGKFGRVYLAKERSSGFVCALKVLHKSELQQGGVQKQVRREIEIQSNLRHPNVLRLYGHFHDSKRIFLILEFAGRGELYKHLRKEHRFPEWKAAQYIAQMAAALKYLHKKHIMHRDIKPENILVGIHGEIKISDFGWSVHAPNNRRQTMCGTLDYLPPEMVNPGSKDNYYSEKVDLWSLGVLTYEFLVGEAPFEDTPIMTHRRIGRADMSVPSFVSPEAKDLIKRLLVLDPAKRIPLEEIQRHPWILKHCVKDDRAVKRSSASSKEGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W6PT81</accession>
    <name>W6PT81_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BRCT domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S01g000770</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PT81"/>
    <dbReference type="STRING" id="1365484.W6PT81"/>
    <dbReference type="OMA" id="VSDHRLK"/>
    <dbReference type="OrthoDB" id="427711at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="197"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM26961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="331" mass="35311" checksum="8761491BEB8514FC" modified="2014-04-16" version="1">MTSDRSERAAKPQPPGPQNHLYFDSWQSASTGHQHAADGGGFLGSTSWRDARSAKLTRQYNSGDCLPGRGRGSGSGLRNTETRESTLVPGVFDGQCAPHSPPKVPASGEWAMVAGDVAKRNELGVRDIRSFMGVSKRKVVDEPEQHTDVETKRLRTVGGNRGLTPARDAREMKKRESQIDGNPQPESHSSASLDLKSTSRIFAGVTVFINGSTLPRISEYKLKHLLASNGAKTSIYMARKTVTHVLVGQPNTGAGSGMDVSGAGGGLAAGKLQQEIARGGWKGVKVVSVDWALESIKAGRRLAESRFPSMHVAAKGQRSVAGMFGAQEPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W6PTN0</accession>
    <name>W6PTN0_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S01g001379</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PTN0"/>
    <dbReference type="OrthoDB" id="10277483at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM27568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="90" mass="9812" checksum="C4E34F77BFF848B3" modified="2014-04-16" version="1">MFIACFSARFLRFLDRSRASGDVRCRTLYSLKRRNGVKDKPQISRQASSLSLVPTRARVSLVSGQLRATARPQFAAGLAVGGGPSIRKCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W6PU72</accession>
    <name>W6PU72_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S01g001110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PU72"/>
    <dbReference type="STRING" id="1365484.W6PU72"/>
    <dbReference type="OMA" id="FWWIGWV"/>
    <dbReference type="OrthoDB" id="428260at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM27301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="71" mass="7896" checksum="2B70E5254253EE1D" modified="2014-04-16" version="1">MDAGRIEIADAIPGKRSAGTLQWAGRPNLFWWIGWVKGIAAATFTQVISQADARFEELTSEFEMAVYAEFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W6PUL1</accession>
    <name>W6PUL1_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g001714</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PUL1"/>
    <dbReference type="STRING" id="1365484.W6PUL1"/>
    <dbReference type="OMA" id="QPRTYAN"/>
    <dbReference type="OrthoDB" id="5372553at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="255"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="432"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="705"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="925"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="294"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="316"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="384"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="445"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="473"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="740"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="925"/>
            <end position="934"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM27903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="965" mass="104155" checksum="5DA5F3316BC573E4" modified="2014-04-16" version="1">MSESAEQLRQMQLLQMADLGTARREMISTDEIRKQARVHIADIESKRRLDQRDEAQLSKWANLHAEIGDTSGMEELDDIECGQSHRANLHAMLHPSGGQPQTYANHLYPTPSAGRGGGVMGKRGRGGFAPLPRGPTNLPPIPPRPSFHGNVTLPGLPGPRGRSATMSASIHLDPALNCNNDDSDARDRGRGRGRGRGRGRGNAQEQVHMPPSAIRPHRASPAVNFATKISEPGDFMSLFQSRRATETYKKPTDTIVSAPIPKTTSSQESIPPNVPRVKMPPSDTPKKKKASILPVAKPASSPVATSTTPSRVVPIETTTSFQPSTAQATTGTKKSQPHIGPYEVETPSRSARVVPLERTASFKTRKAQPDTPKSSQPRNKLPPVEEPTPPPPHSVSVSVKQGGKPKKAKHMVTDSQPLPAMVATATDKIQWKVLPGEEPRKKSTAPPSKTAVSLENSMPLAEAKKTPVTKVTQLKDSKQNVQMEETKHKPQSHDLLSDDTPVMTTPRHFNTVAIKPPVVKVTRLKDSKQNVQMEETKHKPQYHDLLSDDDAPVNSTMITPHHMNTMAVHSPGAAELAGLKFAEKVGESVPSKSIDGVIAPKTTINDSSRELDGFGLYGPKIIEELRDIRKHIRSPQELATAHDIERILESKLLQLIPEAPPPPTAPASSDIEGRLGNLLALVEYLSASQQGTNAVEISSTARRDITPFEGHRSPPPPSSSSNSPPSADKRARKVHVPGLSPTNSESSDVISQFETLQVSDKLAAPLQPQRVVPVPALRPLRIPKKATTSDMSVQATPALGSRAKESTKKPQTLNDSIFAGSVPLVTPNANVIEPNAVRSQTTGRVLSANHPNIPKHQDFQATGARTIGPAPYKPRVIGPAPSAYEPTTLRDVPTAHIRTVSVQHANTENRPSLDVANRASTSMGYFNGPASQQAPGELFSMPDPATILQPKAKAAGFFTSNQSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W6PUT4</accession>
    <name>W6PUT4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="6">40S ribosomal protein S14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rps-14</name>
        <name evidence="6" type="ORF">PROQFM164_S01g001461</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS11 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PUT4"/>
    <dbReference type="STRING" id="1365484.W6PUT4"/>
    <dbReference type="OMA" id="KWGVAHI"/>
    <dbReference type="OrthoDB" id="1677536at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.80:FF:000002">
        <property type="entry name" value="40S ribosomal protein S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.80">
        <property type="entry name" value="Ribosomal protein S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01310">
        <property type="entry name" value="Ribosomal_uS11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001971">
        <property type="entry name" value="Ribosomal_uS11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018102">
        <property type="entry name" value="Ribosomal_uS11_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036967">
        <property type="entry name" value="Ribosomal_uS11_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007176">
        <property type="entry name" value="PRK09607.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11759">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S14/30S RIBOSOMAL PROTEIN S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00411">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002131">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00054">
        <property type="entry name" value="RIBOSOMAL_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="127"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="142"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDM27650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="151" mass="15901" checksum="236B020C5A3CA430" modified="2014-04-16" version="1">MAPKTKTPAAAKENVSLGPLAGDGKLVFGVARIFASFNDTFVHVTDLSGRETICRVTGGMKVKADRDESSPYAAMLAAQDVAVRCKELGINALHIKIRATGGNGTKTPGPGAQSALRALARSGMRIGRIEDVTPTPSDSTRRKGGRRGRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W6PUX8</accession>
    <name>W6PUX8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Siderophore iron transporter mirB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">mirB</name>
        <name evidence="13" type="ORF">PROQFM164_S01g001506</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PUX8"/>
    <dbReference type="OMA" id="DISWRWG"/>
    <dbReference type="OrthoDB" id="4078873at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010106">
        <property type="term" value="P:cellular response to iron ion starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000302">
        <property type="entry name" value="MFS siderochrome iron transporter MirB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000284">
        <property type="entry name" value="Siderophore iron transporter mirB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF50">
        <property type="entry name" value="MFS SIDEROCHROME IRON TRANSPORTER MIRB (AFU_ORTHOLOGUE AFUA_3G03640)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0410">Iron transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="72"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="141"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="169"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="198"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="227"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="284"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="312"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="353"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="390"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="419"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="444"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="482"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="559"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="12">
        <location>
            <begin position="76"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDM27695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="593" mass="65663" checksum="E0F1695CEC5BA8CB" modified="2014-04-16" version="1">MGVSRFRSAFRRSSTQDSVTQIPVTTDGDEKSKIPTDPVAVPNSADPEVPTQDAQQGVRDVEAVTLSWTRTMLIAVFANIWFLYFVNAMQSSINYSLLSYVTSDFESHSLLNVIYIVADAMTASVYIPTAKIMDVWGRAEGFLVMTVFATLGLILMAVCHNLPTFCAAYVFYSIGFGGMTYCVDVITADISKLKNRGLAYAFTSSPYIITAFAGPKAAEGFYEDISWRWAFGAFSIIFPIVASPLYFILKSNLKKAQKNGLLVPEPSGRNWWQSIWHYTKEFDLLGVLVFSTGLTIFLLPFSIATYAPKGWASGYIIAMIVIGFVMLGLFLVWEFRFAPTPMFNFRLLTDRTIIGACLLDATYQLSYYCWNNYYTSFLQVVNDLTISEAGYVSNTFDVVSGFLLLGVGFIIRKTGRFKWTLYIGVPLYIFAQGLMIYFRQPDQSVGYLVMCQIFISIGGSVFIIVEQLAILAAADHQHVATVLALLNVVGTVGDAAGSTICAAIWTNTFYKALEARLPASAIGDIDLIYEDITQQLSYPVGTPARRAIQSAYAYSQTRMLAVGTGLMGLCIIWAIMIRDIDLKKVAQVKGVVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W6PVB7</accession>
    <name>W6PVB7_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Probable importin c550.11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PROQFM164_S01g001532</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PVB7"/>
    <dbReference type="STRING" id="1365484.W6PVB7"/>
    <dbReference type="OMA" id="WVAKTSW"/>
    <dbReference type="OrthoDB" id="760868at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000244">
        <property type="entry name" value="Nonsense-mediated mRNA decay protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013713">
        <property type="entry name" value="XPO2_central"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997:SF18">
        <property type="entry name" value="D-IMPORTIN 7_RANBP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997">
        <property type="entry name" value="IMPORTIN-7, 8, 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08506">
        <property type="entry name" value="Cse1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="8">
        <location>
            <begin position="24"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="898"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="906"/>
            <end position="924"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM27721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="1050" mass="118985" checksum="77CB335814BE450B" modified="2014-04-16" version="1">MDVTALRDRVQSTLDANADIRRQAELDLKYAETQPGFINGLLDILQGEQNNAVQLSAGVYLKNRITRGWAPVEDSPQRTPIPEIEKPSFRERLIPALASTPPNVRNQLVPLLQKILQNDFPEQWPGFLDLTLQLLSTNDASTVYAGLQCLLAVCRVYRFKAGEKREEFDKIVELSFPQLLSIGSKLVDEESLEAAEMLRIVVKAFKHAIYFELSPCLQTHQATVDWCTLFLRIVSKTPPASSMADSKEEREMNHWWKCKKWSYANLNRLFIRYGNPTTITKSSTPDYTPYAKTFISTFAPEILKGYLTEIDKWVSKTQWLSNSALSYTLVFMEECVKPKAMWDHLKPHMDNLIAHFVFPILCQSDEDIELFEDDPSEYLHRKLNFYEEVSAPDVAATNFLVSLTKNRKKQTFSILTFVNSVVSKYESAPDDQKQPREKEGALRMIGSLASVILGKKSPIADQVEYFFVRHVFPEFRSPHGFLRARACDTLEKFEQLDFKDPNNLMVIYRNILESMTDSELPVRVEAALALQPLIRHDVIRTSMQQNIPQIMQQLLKLANEVDVDALANVMEDFVEVFSAELTPFAVALSEQLRDTYMRIVGELLERNASKGGDEDGYGDFLDDKSITALGVLQTIGTLILTLESTPDVLLHLETILMPVISITLENKLYDLYNEIFEIIDSCTFASKTISPSMWQAFELIHKTFKAGAELYLEDMLPALDNYVAYGSDMLVQNPAYLDAMVGMVQDIFSDEQVGGVDRICGCKLAETLMLNLRGHIDQYIPMFIEMAMRVIDAGEASTKSYRIHLMEMVINAIYYNPALSLQVMEAKGWTNKFFSTWFANIDNFRRVHDKKLSIAAISSLLTLKAADVPVSVQQGWPRLLQGVTRLFQTLPAALKQREDATKESDFTLDDEDDEDDEDNDWDGDVEWDENEVEAALEEGDVHDESAAYLDFLNQEAQKFGSYTDDDDDDMDEESLLETPLDKLEPYGMFKHVLLSLQQEQPQLYESLTKVLGHEEQQVIQGVFHEADAKAMVAAANAEAAAAAGMQANGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W6PVU2</accession>
    <name>W6PVU2_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Probable transposable element</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S01g002149</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PVU2"/>
    <dbReference type="STRING" id="1365484.W6PVU2"/>
    <dbReference type="OMA" id="WHINICL"/>
    <dbReference type="OrthoDB" id="4359445at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018289">
        <property type="entry name" value="MULE_transposase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47718">
        <property type="entry name" value="OS01G0519700 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47718:SF3">
        <property type="entry name" value="PROTEIN FAR1-RELATED SEQUENCE 5-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10551">
        <property type="entry name" value="MULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="47"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="MULE transposase" evidence="3">
        <location>
            <begin position="35"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM28338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="177" mass="20081" checksum="C5655F77A7C3B91C" modified="2014-04-16" version="1">MNTKPTYNFTLATQVRIPGLCNIVYIAMLKSDLWVISMDYTYNTNGYGLPLLAIVGFAATGSTFHIGFAFMKNEKQDTYELILDRLAEAYESLGLKYPPTILTNKEEALMKAIEAIFPDTKNMICIWHINICLLSYLYHQGKRPRCPSHFTGSLSQPQARTTTEHSFKVSRAKIQNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W6PWC3</accession>
    <name>W6PWC3_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g002359</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PWC3"/>
    <dbReference type="STRING" id="1365484.W6PWC3"/>
    <dbReference type="OMA" id="GHSIFRY"/>
    <dbReference type="OrthoDB" id="4362946at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="215"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM28548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="530" mass="59073" checksum="87819A6A26BA9945" modified="2014-04-16" version="1">MKRFCHSLKCWGCRCDCSDDSDSDGQTLPLPKTAPRGGHNAPSTMTYPKNVTAKAPKPGKDPKPAEPKNKAKPQEAATDNDGNSRTEITPDMSDIDMNDASDGRISDNPSPPRSDSDIDMPDADPGELLTYPLARMSQNRRTLSNAGESESSSDDDDALYFGSPRPRAPISLRAAHQSGRIERWSLRSSNDSMQSYSGRKRGHVEEVEDVNQEWSPAPSSHGSPPSKRQRTSGESSTEGRFWGPELLFPEPPTSPNIAASSDSEDFNTDDEMYEKPSTTTINRYREKGAQLQAWLEDPNEPDCNIAPATATLDDLMNAPPPDVFELGESYHRDLGDLMDGGEPESTGLPTEGNRYRHTAFFNNVLNPETLARFNFPSLSNSYTHLVGPGLLVADSIFRYDNIQWNEFAKAVYEYDHPMSTLRYIMFTHVVNDETGPYIRRILYPRLGRDFEAAMHESCMKVERGTAEYEELLGTKLGKAAAILLISSLPRGTRRIARVVIWNWVYRVQIRFEIEPIIANSDDQPETAGDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>W6PWK1</accession>
    <name>W6PWK1_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="10">High-affinity glucose transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">HGT1</name>
        <name evidence="10" type="ORF">PROQFM164_S01g002449</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PWK1"/>
    <dbReference type="STRING" id="1365484.W6PWK1"/>
    <dbReference type="OMA" id="VFFMYPE"/>
    <dbReference type="OrthoDB" id="4142200at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17356">
        <property type="entry name" value="MFS_HXT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000026">
        <property type="entry name" value="MFS quinate transporter QutD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF7">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="273"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="309"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="336"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="381"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="421"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="452"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="9"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDM28638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="528" mass="58227" checksum="F204DE63C5528BD6" modified="2014-04-16" version="1">MMITNIYVITVIAVIGGSLFGFDLSSMSAILSTKQYRCYFNEGPNGPPFNDESHCSGPGSNLQGGITASMSGGSFIGALISGFVTDIFGRKSAIQLGAIVWIIGSTLCCAAQNIPMLIVGRFVNGLCVGICSAQVPVYVGELAPPHLRGLVMGAQQWAITWGVLIMFYISYGSSFLTGPLAFRLPWGLQMIPAIFLFIGLLFTPESPRWLAKKDRWEECCHIISSIHANNNLDENFIQMEIQQLKDACELERDRTDNSYIDLFRPHMLWRTHIVVFVQIWCQLTGINAILYYITYIFGMTGLSGSSNLVASSISSVINVIMTIPALLFMDRVGRRPLLIGGSISLFIWWTLCAGLMGGYGVAAPPGGLDNIPEESWLITGAPAKVVIACSYLIVASFAPTWGPIEWVYPSELFPLRLRGKAAALSTASNWAFNFALSYFIPPAFVNITWKTYIIFAVFAFAMTLHVFFVFPETSGRTLEEVEDAFKGVTLAWNMGAEKFKDEEITLEYEPKQDESEKAVHVEDTIRST</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W6PWU8</accession>
    <name>W6PWU8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidoglycan-binding lysin domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S01g000243</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PWU8"/>
    <dbReference type="STRING" id="1365484.W6PWU8"/>
    <dbReference type="OMA" id="DCTNLWK"/>
    <dbReference type="OrthoDB" id="5985073at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052210">
        <property type="entry name" value="LysM1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34997">
        <property type="entry name" value="AM15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34997:SF18">
        <property type="entry name" value="LYSM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0843">Virulence</keyword>
    <feature type="domain" description="LysM" evidence="3">
        <location>
            <begin position="16"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="3">
        <location>
            <begin position="102"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM26434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="190" mass="20046" checksum="ACDC9E6412E90B22" modified="2014-04-16" version="1">MGYKAAMISATVVCNFSSVPNKGDTCSSFASSWGQTLANFQALNIGISCSTLTAGQSCCIVGTVKDEPATTTSTITTTALTTTTSTSQYDPTQSGIPPSCDGFHLIASGDQCDTIEAKYGITEAQFKAWNPSIDSSCSNLWLDYYVCVQIPGATTTTSTPQTTSTGPWPQMPGVASNCKPFYKIKSDDNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W6PX75</accession>
    <name>W6PX75_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GPI-GlcNAc transferase complex, PIG-H component, conserved domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PROQFM164_S01g002192</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM164</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PIGH family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PX75"/>
    <dbReference type="STRING" id="1365484.W6PX75"/>
    <dbReference type="OMA" id="WRGSRHC"/>
    <dbReference type="OrthoDB" id="6256716at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000506">
        <property type="term" value="C:glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044215">
        <property type="entry name" value="PIG-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019328">
        <property type="entry name" value="PIGH-H_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15231">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15231:SF1">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10181">
        <property type="entry name" value="PIG-H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidylinositol N-acetylglucosaminyltransferase subunit H conserved" evidence="4">
        <location>
            <begin position="114"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDM28381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="204" mass="22778" checksum="A89DE99C6F7031A7" modified="2014-04-16" version="1">MRGRLEVQRPSPTTVSFTVSNAPQQSSSPAKIIFGLQVLLRTVLFFCVIGVGIARVRNLFFQEDGRVISWPALWSSPLGSKLCRLVDSYNPLGIAVAGALVIYGVFRRGHIEESLLVIRGFGIQTSTSSSTYLSTASTRFIPTTQIQDIVIHEAFKGFEVRFYLAVIVEGELDALVVFPHMLPRREILEQVWRGSRRCLYDAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>W6PXA5</accession>
    <name>W6PXA5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type DNA-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PROQFM164_S01g000403</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PXA5"/>
    <dbReference type="STRING" id="1365484.W6PXA5"/>
    <dbReference type="OMA" id="HIQADDW"/>
    <dbReference type="OrthoDB" id="3034343at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001080">
        <property type="term" value="P:nitrogen catabolite activation of transcription from RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050797">
        <property type="entry name" value="Carb_Metab_Trans_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668:SF4">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN DAL81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="75"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="138"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="142"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="160"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="183"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM26594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="741" mass="83729" checksum="6EA36EE37E6D99B9" modified="2014-04-16" version="1">MEIKVAQVVCRAVWKPSPLDHDKHASVLKIRLRFSQRSGGSSSSLIFSKIAFIMEYSVSAPVLNGRLYKSRKCRPCDACRKRKVACDMPHGPPCHRCTNRDQECTFEEGPGPRKRARLYEQLETFETCEQPDGWLHLLTETRPNDGKDVEGFTPEETRQAESISPQRSDSPVSRYGTAGVGSRGSISSSPEMSPPSRERPAFRDSPSQVDSLEFIPGAFSFYIGPTGVSDIHILSHQAYDGQNVSLPKVNGLKYRIMDNAHQKEGKPFELSHPTVFGITDHSLLEKAEPKLDPQLTDNAWPRLWAMMDPTAAWHLIKLYSRYVDPYFPILSSHQIPSSPGELVRMPLALLTAICATALPFVMYDDSLYTLLLNPPSSEQLYRLCWLCLSQELHAPSLATLQACLLLQQRLPTNMYLSDTAFTWTLSSTSLAVAQTIGLHRDPESWMSIPPWEKRLRRRLWWGLYIMEKWVALARGMPSHLGDDDYDVSLLQQEDIQDTLSDSPDTKSHMYHLSTLTTILWDIQRSFYSVKAIGKTSNDLQYSLDLARPMRVKLKDWRENLPSNLKSTSNAANSGGDLDGNGSLYLSYIVTHVALLRALLRPLDRWPTIIQRNKEEPDATYEGAKAVVKGALLCVKEFVEFVEKLTGAQWNSFWHSWSRPNFAIAGSFMVHLLQIVTPSNRAEIPATFELAKYSFEKEYAELQSWIRRWRWATRISANGAAGVKGLTNLGFIKVETLMGNVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W6PXK9</accession>
    <name>W6PXK9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Restriction of telomere capping protein 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rtc5</name>
        <name evidence="3" type="ORF">PROQFM164_S01g000503</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PXK9"/>
    <dbReference type="STRING" id="1365484.W6PXK9"/>
    <dbReference type="OMA" id="KWEFEAR"/>
    <dbReference type="OrthoDB" id="289228at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00584">
        <property type="entry name" value="TLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TLDc" evidence="2">
        <location>
            <begin position="353"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="319"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="326"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM26694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="637" mass="69315" checksum="7F3A8B845F631C9F" modified="2014-04-16" version="1">MGAAQSNEHGASSPEELSYMLAERFATKCFTPLELTHFKDNFFSRALEQGGLRHWNEKVLSDFLGIPDGIFTSSQEQPLDAGPVIFRMVSYLGAFPFQNTLAPSVLTFEAMVKVVVLLTDRYGKALKRGHKDRIKLLFGSLADVGRKTPAEANGECTTEDSEASAGNSHALGFSIDKPANDDYDEDEDDDLALAALDSLDAIEVFKHDHRVDKTVYETRISIDTFRRLVMLLLVIAPLKPLDSLKIYTSGLDVRRMESVKNEADSIIAAFSPEESDGGISYKSFARTISLSLPYLFDPLTALFEHLLFSKNLNLSQRRHKGLATETEPEESEENEEPPLQPAALTLPGSFESAILNPTVNSHLSFFLPSISPDINILRGGVKLHPVFSTNAHGSSLTYFSHHVLTWQSATLLILQGALVDSSSEELITLGAYIPQTWKTASSTSGSSSKTSDILPCLFQLSPKHLLLPGNPSPSAKKPNTPIAYFSPNTGIAIGCQIPAPSRTHQTYPTPHGAGSLIIDANIETAEFHAAPIGHDGAFLPASNTSPEDPPTKIKLDLYTLEIWGIVPDPEASSSAETNLGPVEIQRAKWEFEAREAERRRNINIKAGAGDSAAESARWLLEAAGIIGDESRYSGGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>W6PY66</accession>
    <name>W6PY66_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Nitrite reductase [NAD(P)H]</fullName>
            <ecNumber evidence="19">1.7.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="primary">niiA</name>
        <name evidence="23" type="ORF">PROQFM164_S01g002507</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>NH4(+) + 3 NAD(+) + 2 H2O = nitrite + 3 NADH + 5 H(+)</text>
            <dbReference type="Rhea" id="RHEA:24628"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16301"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.7.1.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>NH4(+) + 3 NADP(+) + 2 H2O = nitrite + 3 NADPH + 5 H(+)</text>
            <dbReference type="Rhea" id="RHEA:24632"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16301"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.7.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>siroheme</name>
            <dbReference type="ChEBI" id="CHEBI:60052"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Nitrogen metabolism; nitrate reduction (assimilation).</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the nitrite and sulfite reductase 4Fe-4S domain family.</text>
    </comment>
    <dbReference type="EC" id="1.7.1.4" evidence="19"/>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PY66"/>
    <dbReference type="STRING" id="1365484.W6PY66"/>
    <dbReference type="OMA" id="MWGGVTN"/>
    <dbReference type="OrthoDB" id="432169at2759"/>
    <dbReference type="UniPathway" id="UPA00653"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008942">
        <property type="term" value="F:nitrite reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015980">
        <property type="term" value="P:energy derivation by oxidation of organic compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042128">
        <property type="term" value="P:nitrate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd19944">
        <property type="entry name" value="NirB_Fer2_BFD-like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03529">
        <property type="entry name" value="Rieske_NirD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.413.10:FF:000007">
        <property type="entry name" value="Nitrite reductase [NAD(P)H] large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1100:FF:000002">
        <property type="entry name" value="Nitrite reductase large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1100">
        <property type="entry name" value="BFD-like [2Fe-2S]-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="entry name" value="Rieske [2Fe-2S] iron-sulphur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.413.10">
        <property type="entry name" value="Sulfite Reductase Hemoprotein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007419">
        <property type="entry name" value="BFD-like_2Fe2S-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041854">
        <property type="entry name" value="BFD-like_2Fe2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052034">
        <property type="entry name" value="NasD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005117">
        <property type="entry name" value="NiRdtase/SiRdtase_haem-b_fer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036136">
        <property type="entry name" value="Nit/Sulf_reduc_fer-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006067">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045854">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006066">
        <property type="entry name" value="NO2/SO3_Rdtase_FeS/sirohaem_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012748">
        <property type="entry name" value="Rieske-like_NirD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02378">
        <property type="entry name" value="nirD_assim_sml"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43809">
        <property type="entry name" value="NITRITE REDUCTASE (NADH) LARGE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43809:SF1">
        <property type="entry name" value="NITRITE REDUCTASE (NADH) LARGE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04324">
        <property type="entry name" value="Fer2_BFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01077">
        <property type="entry name" value="NIR_SIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03460">
        <property type="entry name" value="NIR_SIR_ferr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13806">
        <property type="entry name" value="Rieske_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00469">
        <property type="entry name" value="PNDRDTASEII"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00397">
        <property type="entry name" value="SIROHAEM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="ISP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56014">
        <property type="entry name" value="Nitrite and sulphite reductase 4Fe-4S domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55124">
        <property type="entry name" value="Nitrite/Sulfite reductase N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00365">
        <property type="entry name" value="NIR_SIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="11" id="KW-0274">FAD</keyword>
    <keyword evidence="8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0349">Heme</keyword>
    <keyword evidence="13" id="KW-0408">Iron</keyword>
    <keyword evidence="14" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0534">Nitrate assimilation</keyword>
    <keyword evidence="12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="22">
        <location>
            <begin position="917"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="377"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00050114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00051413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00066907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00070300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="CDM28696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="1084" mass="120058" checksum="B6EEDAFEFCC0A67B" modified="2014-04-16" version="1">MPVLDGLRYGEPVDGSPSPATHVQRQKIVVVGLGMVAISLIEKIIKQDTERKYDIVVIGEESHVAYNRVGLSSFFEHRKIEDLYLNPTEWYDSFKERSFDHHINTRVTAINPKEKTVQTSTGDTIAYDILVLATGSDATLPTHTPGYDAKGVFVYRTISDLERLIDFAAQHKGQTAVTVGGGLLGLEAAKAMTDLEDFGNVKLIDRNKWVLARQLDGDAGSLVTRKIQELGLDVLHQKRVKIVHTDEGNNVTGITFEDGESIDCCCICFAIGVQPRDELGRNIGIQCGERGGFVIDECLQTSIPDIYAVGECASWENQTFGIIAPGIEMADVLAFNLTNPDKQPRGFTRPDLSTKLKLLGVDVASFGDFFADRDGPKFLPGRRPSTGPGLGGDTSLEEPPVKALTYKDPFSGVYKKYLFTMDGKFLLGGMMIGDTKDYLKLNQMVKLQKELEVPPSQFILGAQNGGEENADDLDDSTQICSCHNVTKGDVADNVKNGTCTTIAQVKSCTKAGTGCGGCMPLVQSIFNKTMLEMGQEVSNHLCSHIPYSRADLYNIVAIKQLKTFVDIMKAVGKNPESLGCELCKPAIGSILSSLFNPHVMDKGINDLQDTNDKFLANIQRNGTFSVVPRIPGGEITADKLISIGSVAKKYGLYCKITGAQRIDMFGAKKQDLLNIWTELVDAGMESGHAYAKALRAIKSCVGTTWCRFGVGDSVGMAIRLEERYKSIRAPHKFKGAVSGCVRECAEAQNKDFGLIATENGFNIFVGGNGGAKPRHAELLVTDVPAEMVMPIIDRYLIFYIRTADKLQRTARWIENLPGGIHYLKEVIVDDKLGICADMEKQMRELVDTYFCEWTETVKDPKRRKVFQQFANTDETVETVEVIQERSQQRPTYWPKDSAEREDFKGHKWSSVSWQPVVRADHFSDEPPQVSSANVKRGDTQLAIFKIKGKFYATQQMCPHKRAFVLSDGLVGDDDAGKYWVSCPYHKRNFELNGEQAGRCSNDESMNIATFPVEERDDGWVYVKLPPIEELDSILGTEKWKVRKSETEDPFHKVDKKFKGMKGKKVTDGFLTGVSAVQPAKSIDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W6PYH9</accession>
    <name>W6PYH9_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PROQFM164_S01g002592</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PYH9"/>
    <dbReference type="STRING" id="1365484.W6PYH9"/>
    <dbReference type="OMA" id="NTFFWGA"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000064">
        <property type="entry name" value="MFS allantoate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF10">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="315"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="346"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="378"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="410"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="24"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM28781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="496" mass="54826" checksum="87AE2DF698421C38" modified="2014-04-16" version="1">MAMETITPDHAMAKRVLRKIDRRLVPLLFTTYMFNFMDKTILSSASVFGMRDDTGLVGQQYSWVSSIFYFGYLGWVYPTTLLITRLPAAKYLTANTLFWGAVVALTAACTNFGGLITVRFLLGVAEATITPAFMFITSTWYTRDEIPTRTGLWFAGNSVGGIISSLLAYGLGHVKDNVGPWRWMFIVLGCATFLWGFAVWALLPDSISKAKFLSEEERQFASNRVVIAGTGATEKTAWRWDQVVECLMDPKTWLIFGLELCTQIPNGGTQNFANLVIVSFGFTNLQSTLLTIPYSLITVATITGTGWLAGRFRQLNCLLIVAVVIPCVVGSAIIYSRAHIVLGVQFFGYFLLSTGPAAMPLAMSLVQANYRGVTKKMTVTAMLFLAYCAGNISGPQFFLSEEAPTYNTAFRTIMICYALAVVLALVLRFYLQWSNARRVRLEGFEGSAGNSGAVGGKGLDADDSNNVADMVNRVQLVSNDYEDVTDWKTPGFRYRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W6PYI5</accession>
    <name>W6PYI5_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Peptide hydrolase</fullName>
            <ecNumber evidence="14">3.4.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">lap2</name>
        <name evidence="17" type="ORF">PROQFM164_S01g003140</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">FM164</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M28 family. M28A subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="14"/>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PYI5"/>
    <dbReference type="STRING" id="1365484.W6PYI5"/>
    <dbReference type="OMA" id="VRFCFWT"/>
    <dbReference type="OrthoDB" id="10013407at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03876">
        <property type="entry name" value="M28_SGAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02130">
        <property type="entry name" value="PA_ScAPY_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000054">
        <property type="entry name" value="Peptide hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.30.30:FF:000030">
        <property type="entry name" value="Peptide hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045175">
        <property type="entry name" value="M28_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041756">
        <property type="entry name" value="M28_SGAP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046450">
        <property type="entry name" value="PA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147">
        <property type="entry name" value="METALLOPEPTIDASE M28 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147:SF57">
        <property type="entry name" value="PEPTIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52025">
        <property type="entry name" value="PA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 17" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="7 14" id="KW-0645">Protease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="9 14" id="KW-0732">Signal</keyword>
    <keyword evidence="11 14" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005151050" description="Peptide hydrolase" evidence="14">
        <location>
            <begin position="17"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="PA" evidence="15">
        <location>
            <begin position="118"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M28" evidence="16">
        <location>
            <begin position="229"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU361240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CDM29328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="488" mass="52490" checksum="BB86E82055959640" modified="2014-04-16" version="1">MKWLFLITLSVGLAEAGRRKPLVSPNDFPSTIRLKDLLKGTQQLEDFAYAYPERNRVFGSAAHNDTVDFIYRELKKTGYYNVWKQPQVHTWTTANTSLTLEGESIKASAMTYSPSVEVTAELAVVSNLGCSASDYPSDVAGAIALVQRGECTFAEKSLLAAAANAAAVIVYNNVAGSLSGTLGGVSSDYSAIAGVSDVDGKVLLSAAEKGAVTVSLLLDSRVENRTTFNVIAETKGGDHNNVVSLGGHTDSVDAGPGINDDGSGIISNLVVAKALTRFSVKNAVRFLFWTAEEFGLLGSEYYTSHLDADELAKIRLYLNFDMIASPNYALMIYDGDGDAFNQTGPAGSAQIEALFEKYFRSKKLPYVPTEFNGRSDYEGFISRGIPAGGLFTGAEGLKTEAEAKLFGGQANVSYDVNYHAVGDNFKNLNHEAFLINSKATAFAVAKYANSLASIPRRSATDKREVKKREPRAHAHTAETGCFHSLVEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W6PYQ8</accession>
    <name>W6PYQ8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PROQFM164_S01g003215</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PYQ8"/>
    <dbReference type="STRING" id="1365484.W6PYQ8"/>
    <dbReference type="OMA" id="NMHEYFD"/>
    <dbReference type="OrthoDB" id="19714at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034715">
        <property type="term" value="C:pICln-Sm protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039924">
        <property type="entry name" value="ICln/Lot5/Saf5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21399">
        <property type="entry name" value="CHLORIDE CONDUCTANCE REGULATORY PROTEIN ICLN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21399:SF0">
        <property type="entry name" value="METHYLOSOME SUBUNIT PICLN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03517">
        <property type="entry name" value="Voldacs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="253"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDM29403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="295" mass="31564" checksum="7A9A6F9DF5FEFAF8" modified="2014-04-16" version="1">MEVIRSSPEASSFVPLAEHQSRTPSSFYSGPPVLYYHSQRCKIVILERELLAAPALNALRGQEATNNAALSHDQQDGDEKEIAISGVDTWVTSDKFLLFSPAASTGVSIPYPSISLHALQRLRVPDSDAEVQGLYMQVATPDAGAPSADDEEECLTMTVVLPADAALAEPVERETDTPTQQLYDAVSACSNLHPDPLDQGDEDDGDGPRFVSAEEHDGVFQLGNGGLPPPVDGSSGWITADNMDQFFDADGNWIAAGEPPSFPLGPGAGTVRAREGENGVEENGVEDETKWRKTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W6PZ40</accession>
    <name>W6PZ40_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PROQFM164_S01g002807</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PZ40"/>
    <dbReference type="STRING" id="1365484.W6PZ40"/>
    <dbReference type="OMA" id="MPEIPGA"/>
    <dbReference type="OrthoDB" id="1055148at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF9">
        <property type="entry name" value="P450, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="471"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM28996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="552" mass="62075" checksum="2ECDD1EDE8190FC4" modified="2014-04-16" version="1">MDTKVQEVLSPLSYRLIQLVGHHNTLPVLVALGVVLVSYVIYNVAFATDIPYIKGLPEIPGAVPVFGHLLKLGEDHATVCEKWWRQYNQPVFQIKLGNTRAVVVNSFDDCKKMLLGNQNAVIDRPKLYTFHGVISSTQGFTIGSSPWDESCKKKRKAAGTALGRPALRNYFPMFDLESFCIVRDMKGDSRNGELEVDVRPYIQRYALNTTLTLCYGIRMDEVYDELLREILHVGSAISLLRSASENLQDYVPFLRYLPNNEKNARSQELRDRRDAYLNLLLDKVRDMIKRGVDKPCISAAILKDMESKLTGVEVSSICLSLVSGGFETIPGTLTSCIGSLCTAEGQIWQDRAYEDIKRHFPDMRDAWTASFVEEKIPYINAIVKEAGRYYTVSSMSLPRKTVTEVNWNGAIIPPKTMILINAQAGNHDVDHYGPDAGRFDPERWLKSIDPPAEAEVNGLGHLSFGTGSRACSGQYIASRLVYTALVRILSSYKIVASETHPPNTDYVDYNQFKTALVAIPREFKVRLIPRDSNMTSECLDAAEQRTKEHYKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q236</accession>
    <name>W6Q236_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Phosphatidyl-N-methylethanolamine N-methyltransferase</fullName>
            <ecNumber evidence="18">2.1.1.71</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Phospholipid methyltransferase</fullName>
            <shortName evidence="18">PLMT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">OPI3</name>
        <name evidence="20" type="ORF">PROQFM164_S02g000205</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17 18">Catalyzes the second two steps of the methylation pathway of phosphatidylcholine biosynthesis, the SAM-dependent methylation of phosphatidylmonomethylethanolamine (PMME) to phosphatidyldimethylethanolamine (PDME) and of PDME to phosphatidylcholine (PC).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine + S-adenosyl-L-methionine = a 1,2-diacyl-sn-glycero-3-phosphocholine + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32739"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64572"/>
            <dbReference type="EC" id="2.1.1.71"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16 18">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine + S-adenosyl-L-methionine = a 1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32735"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64572"/>
            <dbReference type="ChEBI" id="CHEBI:64573"/>
            <dbReference type="EC" id="2.1.1.71"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 18">Phospholipid metabolism; phosphatidylcholine biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="18">Endoplasmic reticulum membrane</location>
            <topology evidence="18">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="18">Mitochondrion membrane</location>
            <topology evidence="18">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="18">Belongs to the class VI-like SAM-binding methyltransferase superfamily. PEMT/PEM2 methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.71" evidence="18"/>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q236"/>
    <dbReference type="STRING" id="1365484.W6Q236"/>
    <dbReference type="OMA" id="PTFWNIA"/>
    <dbReference type="OrthoDB" id="8300106at2759"/>
    <dbReference type="UniPathway" id="UPA00753"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000773">
        <property type="term" value="F:phosphatidyl-N-methylethanolamine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006656">
        <property type="term" value="P:phosphatidylcholine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1630:FF:000005">
        <property type="entry name" value="Phosphatidylethanolamine N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03216">
        <property type="entry name" value="PLMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024960">
        <property type="entry name" value="PEMT/MFAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007318">
        <property type="entry name" value="Phopholipid_MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15458">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15458:SF5">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04191">
        <property type="entry name" value="PEMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005444">
        <property type="entry name" value="PEMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51599">
        <property type="entry name" value="SAM_PEMT_PEM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 18" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3 18" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="10 18" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 18 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 18" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11 18" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13 18" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="14 18" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 18" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 18" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 18 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 18 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="topological domain" description="Lumenal" evidence="18">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="intramembrane region" description="Helical" evidence="18">
        <location>
            <begin position="13"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="18">
        <location>
            <begin position="34"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="18">
        <location>
            <begin position="112"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="18">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <begin position="95"/>
            <end position="97"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <begin position="177"/>
            <end position="178"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00051252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00052459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00056845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CDM30056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="196" mass="21753" checksum="33D5F0E05AD1CC39" modified="2014-04-16" version="1">MASLTDFVDFSSKPLLWSAATIAFNPIFWNIVARAEYRNHFLTRLFGGAKNGCYFLAVTIFSLGILRDHVYQLALADQPFYAPVHQPIVGGVLFTIGSVLVLSSMWALGVTGTYLGDYFGILMDAPVTGFPFNVTGSPMYWGSTLNFLGVALYHGKVAGILLTAQVFVLYWFALGWEDPFTAEIYAKRERARAKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q261</accession>
    <name>W6Q261_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Cytochrome c oxidase subunit 9, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11 12">Cytochrome c oxidase polypeptide VIIA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">cox9</name>
        <name evidence="14" type="ORF">PROQFM164_S01g002075</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the fungal cytochrome c oxidase subunit 7a family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q261"/>
    <dbReference type="STRING" id="1365484.W6Q261"/>
    <dbReference type="OMA" id="ASYWWWG"/>
    <dbReference type="OrthoDB" id="2317211at2759"/>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22888">
        <property type="entry name" value="CcO_VIIa_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014368">
        <property type="entry name" value="Cyt_c_oxidase_su7a_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28264:SF1">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 6C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28264">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 7A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000283">
        <property type="entry name" value="COX9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR000283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDM28264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="62" mass="7165" checksum="6F2895A7A33438ED" modified="2014-04-16" version="1">MPAAIPPITGMLRRGLVLDLSTAFGFGTTFGYLWWYGYHLPRVRERDTYYARLEVERAAQRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2024-10-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q2A4</accession>
    <name>W6Q2A4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S02g000270</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q2A4"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM30121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="22" mass="2488" checksum="1620B765E50D1457" modified="2014-04-16" version="1">MTARLVLVIGDLFIPDRAPSRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q2E5</accession>
    <name>W6Q2E5_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="6">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PROQFM164_S02g000863</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4 6">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the PPP phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="6"/>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q2E5"/>
    <dbReference type="STRING" id="1365484.W6Q2E5"/>
    <dbReference type="OMA" id="QSTMPID"/>
    <dbReference type="OrthoDB" id="1930084at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07415">
        <property type="entry name" value="MPP_PP2A_PP4_PP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047129">
        <property type="entry name" value="PPA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45619">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF033096">
        <property type="entry name" value="PPPtase_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="8">
        <location>
            <begin position="108"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="187"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="187"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="227"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="5">
        <location>
            <position position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR033096-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM30713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="422" mass="45974" checksum="4DBF61E3D924E805" modified="2014-04-16" version="1">MSNLDRAIEQLRACRLIPESQVRELCYKARELLIEEGNVVSVDAPVTICGDIHGQFHDLMELFRVGGDVPDTNYLFMGDFVDRGFYSLESFLLLLCLKVRYPDRITLIRGNHESRQITTVYGFYDECIRKYGSANVWRYCCEVFDYLALGAIVLGASSELVPTSASSNEDELEIEVLDSKGVVTMNTYRPRQRSSSEASTDSRNISPPRDISAAPGQAAAPSRSGAPGTGASGDGNGSAVTSRTGAVLCVHGGLSPLIDSVDKIRLIDRKQEVPHEGAMCDLLWSDPDEIEGWGLSPRGAGFLFGGDIVKQFNHLNGLSLVARAHQLVMEGYKEMFDGGIVTVWSAPNYCYRCGNVAAILELGEDTSGGGTVARSNGEYGRSNGIVADNRVVSPGRRYRVFEAAAQDTRGMPAKKPVADYFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q2I2</accession>
    <name>W6Q2I2_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PLC-like phosphodiesterase, TIM beta/alpha-barrel domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S02g000345</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q2I2"/>
    <dbReference type="STRING" id="1365484.W6Q2I2"/>
    <dbReference type="OMA" id="CNNYVEF"/>
    <dbReference type="OrthoDB" id="7984201at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051057">
        <property type="entry name" value="PI-PLC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593:SF140">
        <property type="entry name" value="PLC-LIKE PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26146">
        <property type="entry name" value="PI-PLC_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004879872" evidence="2">
        <location>
            <begin position="19"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="19"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM30196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="467" mass="50609" checksum="64E4B0F71D73F642" modified="2014-04-16" version="1">MRWPTIVLGFLAVAAAQAESTESTESTESTKSTKSSTESGKTTTDEPTIVSVTTPIAIPSGTYQDLTTTITLGDGDKSVIASTTQHNGTMTASNQTQAVTMTSDSLTLLVGGGGGGTTVIGNNSMNATATRTSTSTQAPVVNTRPCNDYPEFCARKYSNITMVAAHNSPFVRKNSVAANQVLDVTTQLNDGIRLLQFQTHYENGTMYLCHTTCQLLNVGTLEAYLVEVNTWMRKNPYDVVTFIIGNYDYVSPANFTTPIYNSGLKDLIYTPTKVPMGLDDWPTLSEMILRQKRAVFFMDYQANQTAYPWLMDEFSQVWETPFSPTDPTFPCTQQRPPGLSVTAAKNRMYMANHNLNLQLNLGSLSLLIPNTASIDETNAVNGSGSLGAMARECNSTWGSPPNFLLVDYYNYGNFNGSVFEVAAQMNNVTYNRKCCGKTSGALREVSIAGISTVLLVAVGVQVVMSAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q2R5</accession>
    <name>W6Q2R5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S02g000993</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q2R5"/>
    <dbReference type="STRING" id="1365484.W6Q2R5"/>
    <dbReference type="OMA" id="HCECDCR"/>
    <dbReference type="OrthoDB" id="10017208at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004881247" evidence="2">
        <location>
            <begin position="22"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM30843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="286" mass="29708" checksum="ECAA5B19D843E6E1" modified="2014-04-16" version="1">MLFRYLLALAIQLCWVALGLANQDATITIPWITDAPDYFQGYGGKAIGAKDGTTTYGINCLSDQTACHRFTPDLTVIYGPSTYDMIANGYRFDFTSGCTLMGSPTPTSASCTETKSLHEASSITSATVVVPATGDDSTLGIFPATLIVTDTGDFPVPFTATETKPSANSHVSTSDASLTAPSTATATATTDPLSLASVGFLNSTAMTTGAPTYFGNGTSPADRNGTTVTVTVLASSIPCHCECDCRGIQTTKATITVPIAMKNHGVKTATPVGLMCGMVVGVMFWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q2Y1</accession>
    <name>W6Q2Y1_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">NADH-cytochrome b5 reductase</fullName>
            <ecNumber evidence="16">1.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PROQFM164_S02g001073</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">May mediate the reduction of outer membrane cytochrome b5.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 16">
            <text>2 Fe(III)-[cytochrome b5] + NADH = 2 Fe(II)-[cytochrome b5] + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46680"/>
            <dbReference type="Rhea" id="RHEA-COMP:10438"/>
            <dbReference type="Rhea" id="RHEA-COMP:10439"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 15 16">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion outer membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.6.2.2" evidence="16"/>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q2Y1"/>
    <dbReference type="STRING" id="1365484.W6Q2Y1"/>
    <dbReference type="OMA" id="WLPVIRP"/>
    <dbReference type="OrthoDB" id="432685at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090524">
        <property type="term" value="F:cytochrome-b5 reductase activity, acting on NADH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06183">
        <property type="entry name" value="cyt_b5_reduct_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000032">
        <property type="entry name" value="NADH-cytochrome b5 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000009">
        <property type="entry name" value="NADH-cytochrome b5 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001834">
        <property type="entry name" value="CBR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370:SF101">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00406">
        <property type="entry name" value="CYTB5RDTASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 15 16" id="KW-0274">FAD</keyword>
    <keyword evidence="4 15 16" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="10 16" id="KW-0520">NAD</keyword>
    <keyword evidence="9 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="17">
        <location>
            <begin position="50"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00037464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR601834-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU361226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CDM30923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="293" mass="32004" checksum="8DBA6A9C6DCD1CEC" modified="2014-04-16" version="1">MFKTRFPQSITAKSASAATLLGIGAYCVQSRLISTANAESNEPPKVFSGFGFTTLRLQSTKDVNHNTKRLVFEFPDQKATSGLALTSALLTISRPEGRWFPVLRPYTPISDLNQEGQIELMVKKYPNGKASSHIHSLSPGDTLTFATALKGHAWTPNQSPQVYLIAGGAGITPIYQLAQGILNNPADKTKINLVFGVNTEQDLLLREELESFKTRFPGRFDYVYAVSHPEGRSDGFRTGYITEGLLREVVKADGDAKVFVCGPPAMEDSLVGSRCQMGILARLGFAKGQIVRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q389</accession>
    <name>W6Q389_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DUF866 domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S02g001218</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0587 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q389"/>
    <dbReference type="STRING" id="1365484.W6Q389"/>
    <dbReference type="OMA" id="TAHFVWR"/>
    <dbReference type="OrthoDB" id="10248838at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008584">
        <property type="entry name" value="CXXC_Zn-binding_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12857">
        <property type="entry name" value="CXXC MOTIF CONTAINING ZINC BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12857:SF0">
        <property type="entry name" value="CXXC MOTIF CONTAINING ZINC BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05907">
        <property type="entry name" value="CXXC_Zn-b_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141678">
        <property type="entry name" value="MAL13P1.257-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM31068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="159" mass="18381" checksum="D074046FEA4724EC" modified="2014-04-16" version="1">MLTLSVEAQMEGVTALQPTDTEENPYFYTFRVQCTSCHETHPNWVSFNRFEVHEIPGSRGEANFVWKCRLCTKTHTASVINGPKPYEVQEKQKAQKILEIDCRGLEFIEFKPDGEWEAKAIESTTTFSGIDLMEGEWYDYDEKKGEEVSIKEITWTVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q3N4</accession>
    <name>W6Q3N4_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">26S proteasome regulatory subunit 6B homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">tbpA</name>
        <name evidence="14" type="ORF">PROQFM164_S02g000731</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q3N4"/>
    <dbReference type="STRING" id="1365484.W6Q3N4"/>
    <dbReference type="OMA" id="QDIGGMD"/>
    <dbReference type="OrthoDB" id="10255768at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19502">
        <property type="entry name" value="RecA-like_PAN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000020">
        <property type="entry name" value="26S protease regulatory subunit 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000049">
        <property type="entry name" value="26S protease regulatory subunit 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="26S protease regulatory subunit 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-0647">Proteasome</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="13">
        <location>
            <begin position="196"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="56"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00068703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDM30581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="419" mass="46922" checksum="CB9D6CA6B8E00152" modified="2014-04-16" version="1">MGDVAVEYPANNVTPLTKLDALANLDSLDGTGADGNDEYATLKRLQRHLEYIQLQEEYIKDEQRSLKRELVRAQEEIKRIQSVPLVIGQFMEAIDQNTGIVQSSTGSNYVVRILSTLDREKLKPSSSVALHRHSNALVDILPPEADSSIAMLGENEKPDVTYADVGGLDMQKQEIREAVELPLTHFELYKQIGIDPPRGVLLYGPPGTGKTMLVKAVANSTTASFIRVNGSEFVQKYLGEGPRMVRDVFRMARENSPAIIFIDEIDAIATKRFDAQTGADREVQRILLELLNQMDGFEQTSNVKVIMATNRADTLDPALLRPGRLDRKIEFPNLRDRRERRLIFTTIAARMSLSPEVDLDALIVRNDPLSGAVIAAIMQEAGLRAVRKNRYNIIQSDLEDAYAVQVKTGQDDDRPDFYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q3U3</accession>
    <name>W6Q3U3_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cell division control protein 48</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">cdc48</name>
        <name evidence="8" type="ORF">PROQFM164_S02g001403</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q3U3"/>
    <dbReference type="STRING" id="1365484.W6Q3U3"/>
    <dbReference type="OMA" id="VWPAYPE"/>
    <dbReference type="OrthoDB" id="27435at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034098">
        <property type="term" value="C:VCP-NPL4-UFD1 AAA ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097352">
        <property type="term" value="P:autophagosome maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051228">
        <property type="term" value="P:mitotic spindle disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071630">
        <property type="term" value="P:nuclear protein quality control by the ubiquitin-proteasome system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030970">
        <property type="term" value="P:retrograde protein transport, ER to cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19519">
        <property type="entry name" value="RecA-like_CDC48_r1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19528">
        <property type="entry name" value="RecA-like_CDC48_r2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000004">
        <property type="entry name" value="Cell division control 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.330.10:FF:000001">
        <property type="entry name" value="Cell division control 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.40.20:FF:000003">
        <property type="entry name" value="Transitional endoplasmic reticulum ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000012">
        <property type="entry name" value="Transitional endoplasmic reticulum ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000048">
        <property type="entry name" value="Transitional endoplasmic reticulum ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.20.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005938">
        <property type="entry name" value="AAA_ATPase_CDC48"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004201">
        <property type="entry name" value="Cdc48_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029067">
        <property type="entry name" value="CDC48_domain_2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003338">
        <property type="entry name" value="CDC4_N-term_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015415">
        <property type="entry name" value="Spast_Vps4_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01243">
        <property type="entry name" value="CDC48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF171">
        <property type="entry name" value="NUCLEAR VALOSIN-CONTAINING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02933">
        <property type="entry name" value="CDC48_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02359">
        <property type="entry name" value="CDC48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09336">
        <property type="entry name" value="Vps4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01072">
        <property type="entry name" value="CDC48_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01073">
        <property type="entry name" value="CDC48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="ADC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54585">
        <property type="entry name" value="Cdc48 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8" id="KW-0132">Cell division</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CDC48 N-terminal subdomain" evidence="7">
        <location>
            <begin position="43"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="CDC48" evidence="6">
        <location>
            <begin position="143"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="5">
        <location>
            <begin position="255"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="5">
        <location>
            <begin position="529"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="729"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="787"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="739"/>
            <end position="750"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM31253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="818" mass="90067" checksum="8B8CED12E2A0FEDB" modified="2014-04-16" version="1">MSSEPDHTHDKKRVHLQDASGAEKKEELDTSTAILKKKKKPNSLIVTDAVNDDNSVIALSNNTMETLQLFRGDTVLVKGKKRKDTVLIVLADDDLDDGSARINRVVRHNLRVKHGDMITVHPCPDIKYAKRIAVLPIADTIEGLTGSLFDVYLAPYFREAYRPVRQGDLFTVRGGMRQIEFKVVEVDPPEYGIVAQDTIIHCEGEPIQREDEEGNLNEVGYDDIGGCRKQMAQIRELVELPLRHPQLFKSIGIKPPRGILMYGPPGTGKTLMARAVANETGAFFFLINGPEIMSKMAGESESNLRKAFEEAEKNSPAIIFIDEIDSIAPKRDKTNGEVERRVVSQLLTLMDGMKARSNVVVMAATNRPNSIDPALRRFGRFDREVDIGIPDPTGRLEIMQIHTKNMKLGDDVDLETIAAETHGYVGSDLASLCSEAAMQQIREKMDLIDLDEDTIDAEVLEALGVTMENFRFALGVSNPSALREVAVVEVPNVRWDDIGGLEEVKRELVESVQYPVDHPEMFQKFGLSPSRGVLFYGPPGTGKTMLAKAVANECAANFISVKGPELLSMWFGESESNIRDIFDKARAAAPCVVFLDELDSIAKSRGGSVGDAGGASDRVVNQLLTEMDGMTSKKNVFVIGATNRPEQLDAALVRPGRLDTLVYVPLPDQDSREGILKAQLRKTPVAGDVDIAYIASKTHGFSGADLGFVTQRAVKLAIKQAISADIDRQKEREAAGEDITMEDEEAEDPVPELTRAHFEEAMKSARRSVSDVEIRRYEAFAQSLKNTGGGSFFRFPSAGEVQENDTFGEAGNDDSLYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q4L4</accession>
    <name>W6Q4L4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S02g001410</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q4L4"/>
    <dbReference type="STRING" id="1365484.W6Q4L4"/>
    <dbReference type="OMA" id="AKVDMCL"/>
    <dbReference type="OrthoDB" id="4363450at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="21"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="404"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="252"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="416"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="434"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM31260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="468" mass="50937" checksum="D85E6822C103D15A" modified="2014-04-16" version="1">MCNPLASPRSDVTVTAVPVSAPVKSTNPKVGLPSGSVAGSSSQSLELPEPSLNKRNAFAQQQGKFPSHLSSHPSRSSLRATTLRSSSIPPVPPLPISILKNRPGNLTLTEFKPRSCSAPPSPPKMAGNSDFPDGNNKPLPVSPRYDLHTPSPRAPIFRRDDMHRPSLSSMERTSGVSLTTVPRSNLTLKDLPEAVRSLQYRYETDIQRLSKKIDNINKLEQKVDDFVTVTRDYIKDQMDAQLERQSDMSFEVTKAKLDVDDVKEQVHDLKEQVAEIKEVVHDMRSDINELTSSFGNLSAKVDMCLGGTDNPDEQFLAYQRRKNKEIDEDIEEIGSQTEDHGKQLLYLRQMLIRSNTALRVLQDEHGLKMSDDVERILPPNPLPARDTVAPTGTLRTRVSSGVGAISPATAAPPVPVAASATMTSPGSSSAKSSIPRRSKKRGSKKSASSSSAKETTEGEAAPSVPTIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q510</accession>
    <name>W6Q510_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S02g001580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q510"/>
    <dbReference type="STRING" id="1365484.W6Q510"/>
    <dbReference type="OMA" id="HHISPAH"/>
    <dbReference type="OrthoDB" id="5426109at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="421"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="425"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="452"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM31430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="554" mass="63627" checksum="BA7CA73C7EE35CF3" modified="2014-04-16" version="1">MPSKQSSRTRFARNISFVKHLLLAPETPALDEAANPTRLASFEKPRMLRHRQSTELLLRPQGRGFQSLIIPYEIIDQDWSSISDVLLSPTVEYLAIDNIYCKNLMAHSNALLDNKFANVMALTIYKSDFDQTVNELCVLLKHCNLHFFQFEEPRGLNNPVQSSLGEVLPYLQYQKSLETLALRTTFCDPSQASISLAQNPWPDLKVLHLRRGHENWLEYLPRFEKLQIICLHHISPAHNGQAIRMISKCRHLQIVDVTFEALADAEALLKIARGCPLLRKFEVYDKSARMGDQNLSQPQFLGLLRALPNVELLTLGLRYRMNGAMLPDLAHYCPRLVSLNLPEARLFLSLLLMHQARPLSNLKIMCLRSVWFDQPRVLMQSDQMQDFVTEWRRVFPKLQTLPCTADIYCMGLYTGDENMYGSLPEDNDVHDESDELPDELDDMTDESHDMTDESNDMTDESNDISSPDFVAEDPQTNTSTADSADDRWYDLDEFGTDCFIFRIKLWRALGFGESNLNHEGFGHMWQTDVEIEVVGWPVMPLEAFSYPEPYSTRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q5T2</accession>
    <name>W6Q5T2_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S02g001831</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q5T2"/>
    <dbReference type="OrthoDB" id="10290180at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM31680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="33" mass="3673" checksum="80464C19E050C451" modified="2014-04-16" version="1">MFIARSEYGKLHQAPSPPKVVCSRSNTLLKLSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q6A2</accession>
    <name>W6Q6A2_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Lipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LIP</name>
        <name evidence="6" type="ORF">PROQFM164_S01g003607</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q6A2"/>
    <dbReference type="SMR" id="W6Q6A2"/>
    <dbReference type="STRING" id="1365484.W6Q6A2"/>
    <dbReference type="OMA" id="GCEVHDG"/>
    <dbReference type="OrthoDB" id="426718at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051299">
        <property type="entry name" value="AB_hydrolase_lip/est"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005592">
        <property type="entry name" value="Mono/diacylglycerol_lipase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46640:SF1">
        <property type="entry name" value="FUNGAL LIPASE-LIKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46640">
        <property type="entry name" value="TRIACYLGLYCEROL LIPASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G06510)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03893">
        <property type="entry name" value="Lipase3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004879944" evidence="3">
        <location>
            <begin position="20"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="Mono-/di-acylglycerol lipase N-terminal" evidence="5">
        <location>
            <begin position="9"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="Fungal lipase-type" evidence="4">
        <location>
            <begin position="104"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDM29794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="294" mass="30888" checksum="600DC573C56AFF1C" modified="2014-04-16" version="1">MLLFGRLWSIAALAALTVAAPSRSVPRDVSADVLGQLTLFSQWAAASYCTNNSNSTGDGVSCEQGNCPLVESADTTTLYEFDETSSYGDVAGFLAVDKTNKLLVVSFRGSRTLSNWIANINFGFTDASSICSGCEAHGGFLEAWEAVAADLTSKIKAAKATYSGYTLVVTGHSYGGALATLGGIVLRNGGYEPSVYTYGQPRVGNKALAQYITDQGSLWRVTHTDDLVPKVPPATVGFSHASPEYWITSGDNTTVTSSDIDVIVGVGSKSGNAGTLNPDTAAHNWYLGHIDACK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q6E0</accession>
    <name>W6Q6E0_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Short-chain dehydrogenase/reductase SDR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S02g002394</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q6E0"/>
    <dbReference type="STRING" id="1365484.W6Q6E0"/>
    <dbReference type="OMA" id="GKRLWEW"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF282">
        <property type="entry name" value="WW DOMAIN-CONTAINING OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM32243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="321" mass="34694" checksum="D708006C0BEF7014" modified="2014-04-16" version="1">MSGWVIAAMDALNYVGAVSFTPESDIPDLTGKVILVTGGNAGLGKETVLQLAKHNPKKIFLGARSKVKAEEAIKSVKSSVPNDVEISWIPLDLMSSKSIKNAAEQVNAQSTRLDVLILNAGVMALPPGETEMGHEIQLGTNHTGHFYLTNLLLPTLLKTAEEPGSDVRVVSLTSVGHNFAPAFEKILDQEKLKKVNTSSRYGASKAANILFAAELSRRYPSITSVSVHPGIIITNLYDALNSSSIFAALGTKFLRLFGSTVQQGACNSLWAAVGAKKEELTNGGYYVPVGILKRRNIWACNEDMGKRLWDWTELELTKANL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q6L2</accession>
    <name>W6Q6L2_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">DASH complex subunit SPC34</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Outer kinetochore protein SPC34</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">PROQFM164_S02g002489</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DASH complex SPC34 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q6L2"/>
    <dbReference type="STRING" id="1365484.W6Q6L2"/>
    <dbReference type="OMA" id="TRRGTMF"/>
    <dbReference type="OrthoDB" id="10016597at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042729">
        <property type="term" value="C:DASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005876">
        <property type="term" value="C:spindle microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008608">
        <property type="term" value="P:attachment of spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013966">
        <property type="entry name" value="Spc34"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08657">
        <property type="entry name" value="DASH_Spc34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="16" id="KW-0137">Centromere</keyword>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="10" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="12 19" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="8" id="KW-0493">Microtubule</keyword>
    <keyword evidence="9" id="KW-0498">Mitosis</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="19">
        <location>
            <begin position="213"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00044112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00044346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CDM32338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="246" mass="27574" checksum="BBD37CE3B4BEFA8C" modified="2014-04-16" version="1">MSLLNSHLEQIRLSSNAIADLPFPPPRIFTTALLGSHDITALIRDTEAHERALFQVDPSTKAHGPQRRATRRGTMFPAETERESMASRIYSARDKRNQSAVARVLGHDMMEEIKRSAGTSTRGPRGEVNIEVLLRGAEILCNVYPVAGAQEKIANLRYRREMISESIAQLEGRVATNTAELDHMRHSYGDDEDDFPPAPVAQPEIPEVTDEDIERELAEIRGLEQRKRRLEERVTGMDRDLGGLIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q6S1</accession>
    <name>W6Q6S1_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Major facilitator superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PROQFM164_S02g002554</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q6S1"/>
    <dbReference type="OMA" id="EWAAFTE"/>
    <dbReference type="OrthoDB" id="6499973at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF130">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="129"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="180"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="216"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="247"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="288"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="331"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="355"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="381"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="413"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="447"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="25"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDM32403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="479" mass="51740" checksum="3C93736E9E348DD5" modified="2014-04-16" version="1">MYKAHQGTMSTSNMANISKKPSSMTEEHTENEKDIDHTRHSSDEESTIRHELNISHIPTNTSALSRTLSAVRTRESGKDLGPPPDGGFQAWSQVALAHFVIFNTWGYINSFGVFQTYYSQTLGHPPSDISWVGSIQIFLLFFIGTFSGRATDAGYFTFTLACGAILECFSIFMTSLCTKYWQLFLAQGVGQGIGCGLMFCPTLALVSTYFAKNRGIAIGLVASGSATGGLVFPAVVMKMLPHVGYGWTIRTLGFISVATLTPCVLFLKQRLPPRKTGPIVEWAAFTELPYLLFAIGMFMNFWGLYVGFFYIGSFSRNIIGVSSDRSIDLLLVMNGVGLVGRLVPNLLADQLTGPLNLLIPFSFATALVGYCWAAVHGLSGLWTFAVFYGLFAAGIQSLFPATLSTLTTDMKKIGVRMGMVLSVVAVAALIGSPIAGELVVRDNGNYLYAQMFMGSAVLLGGLTLIGARVTKVGTGIARV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q7H6</accession>
    <name>W6Q7H6_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S02g002834</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q7H6"/>
    <dbReference type="OMA" id="IGDYSVX"/>
    <dbReference type="OrthoDB" id="4360605at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM32683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="147" mass="16357" checksum="D1812862D81F3EFA" modified="2014-04-16" version="1">MAKDQKPSRGDADRGTATTKPGTGRAYAPSPYSARSTASRSKAERNPLKAVGNHKGLGHSTAKSTRKKDHEATHRKCLDMMDQIQKEVQLALKEIDEERAHDSQSIQRLHTEKAQDTSKLQEAITARDKALGENQRLKRELCQLQQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q7N2</accession>
    <name>W6Q7N2_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Choline dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PROQFM164_S02g002162</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q7N2"/>
    <dbReference type="STRING" id="1365484.W6Q7N2"/>
    <dbReference type="OMA" id="PDNVGTN"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF119">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE OXIDOREDUCTASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00623">
        <property type="entry name" value="GMC_OXRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0134">Cell wall</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0274">FAD</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="7">
        <location>
            <begin position="87"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="8">
        <location>
            <begin position="268"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM32011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="746" mass="82907" checksum="FE18ECEF3131A342" modified="2014-04-16" version="1">MTIPDEVDIIVVGGGSAGCVSAGRLANLDHNLQVLLIEAGEDNLNNPQVFRPGIYPQNIKLDSKTATFYHSQPSKAIDGRRAIVPAARVLGGGSSINFMVYTRASASDYDDFEAKGWTTKELLPLMKKPETYQRHSTKRDVHGFDGPIKASFGNYTYPIMQEFLRAAESQDIPVTDDLQDLQAGHGAEQWTKWINRDTGRRSDAAHAYVHSTREDYENLYLKCNTKVVRVIIENGTAVGIVTVPEKPLKDEKIQKIYRARKQILICGGTLSSPLILQRSGIGDPKKLRQAGIEPIVDLPGVGCKFQDHHLLFSAYRARPDTETFDEFVRGNTDVQNAAINEWISKGTGPLSTNGIEAGVKIRPTEQELEEMKNWPTSDFLSGWESYFKNKPDKPVMHYSVIAGWFGDHLLMPPGKFFTMFHFLEYPFSRGWIHVKSPDPYEAPDFDAGFLNDDRDIAPLVWGYIKSRETARRMDAYAGEVTWMHPSFASDSPARAHDLDLATTKEYGGPAHITAGIQHGSWTIPVDPGMQLPESVISSSRQAIREPIKYSREDIECIELWARRHVETTWHSLGTCSMAPKEGNFKVKHGGVVDERLNVHGVKNLKICDLSICPDNVGTNPYSVALLIGEKCSVLTAEDLGYSGSDLEMKVPTYNAPVWESVELLVCHILVSRYTITKGKVAATIRPVLEGIQYLRGRGRALAALSTNTILLTESGGVRIAEIDALTLKLFALAKVIKRLIIKNPPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q7P7</accession>
    <name>W6Q7P7_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S02g002556</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q7P7"/>
    <dbReference type="STRING" id="1365484.W6Q7P7"/>
    <dbReference type="OMA" id="LCIQDPT"/>
    <dbReference type="OrthoDB" id="273917at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031499">
        <property type="term" value="C:TRAMP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990817">
        <property type="term" value="F:poly(A) RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010605">
        <property type="term" value="P:negative regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043634">
        <property type="term" value="P:polyadenylation-dependent ncRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054708">
        <property type="entry name" value="MTPAP-like_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045862">
        <property type="entry name" value="Trf4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23092:SF50">
        <property type="entry name" value="MTF2-LIKE C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23092">
        <property type="entry name" value="POLY(A) RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22600">
        <property type="entry name" value="MTPAP-like_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Poly(A) RNA polymerase mitochondrial-like central palm" evidence="2">
        <location>
            <begin position="173"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM32405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="449" mass="50103" checksum="53F504D0B55E12A5" modified="2014-04-16" version="1">MVTSTPVSFALFKCPKTVMQLPSLPLRIRPSHLFRPFHSSVAVAKTPDVFANSLRKTLEAHRSTNRSRLIRKIYPVEDPAGLWRPEIPSKSRADYQPTVEPALPDSEYSPDTPDPGSKRRQKKRASLVDIPSHQSLISQRGEDAIQPAGTGRPAQSPWLTNLELSRANAEITLDAEIRALHQYLSLRARERDRVEKLRTEVASLLKTVVPHAPRVIGSHCTGLVLAHSDLDFILPYEDPSRSLERDRRPSPTRPQIQDAHIRLLRQVQRALQHTDIFDNVKISDKRNPSLSARHRPTGLLLQFYCGEDIPAITEYLQDYQAEYPALRPLYAVTRTLLEARGLFGSSQASVGPDALAMLVVAFLKMNHGRFPGPNSLGDQFLALLQFYGTQVDLKSVGVAVDPPGLFSTDMLPVARGADETAHQRGQRSLINVKRTAAGKLNMPLFIFVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q8F4</accession>
    <name>W6Q8F4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S02g003134</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q8F4"/>
    <dbReference type="OrthoDB" id="4494341at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM32983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="72" mass="8170" checksum="532B602912C4AD40" modified="2014-04-16" version="1">MIATGIGIAAQLLYIKELLDGHEKAQMLYVSIYDLLRAYLEDEIQYIGENGLIDVRSGRVSWEKQLDIEIGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q8V4</accession>
    <name>W6Q8V4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transcription factor, fungi</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PROQFM164_S02g002951</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q8V4"/>
    <dbReference type="STRING" id="1365484.W6Q8V4"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF82">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="5">
        <location>
            <begin position="155"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDM32800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="435" mass="49900" checksum="1E2A5B04386C2E1B" modified="2014-04-16" version="1">MQNHERSFTYAGRIGDIIQRWDRTEQCNEWQAPTAVTSPIANLPIHLDYILCEKTQYYRFIARKARTIRKHWRDRHCWVAPVNRSGRRTPHGPSATEQQIQQFTRVVQCQRAFSNAPVSLTSGNANMLWVKLGPIFGFRSKAVTTDGELILGSITWQRLGEFATNIFELGVHRDTTSSTALPLFILESRRRLFAAAYQFDKGIATFLGRPPQISWRHSDCCLPLDIGDHVLTGDPEILDAAQTSLDPQGWNMGKAYQRATWIRFPERTDLLIATILSTVLILGRQWEQSVAIQRDLTWILLLYGIPGASVLIRALQKQAQTGRPMLYSGSQASLIRNLSVFISHLELTARPEQESSTYFNRTAAVFTRILDEILEPRLKIPAPYRDSERNFDVDFDRLFFLGYGWDSTAPEYRFWGIFWSNAVLKETKMTSLKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q9S5</accession>
    <name>W6Q9S5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein kinase-like domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S02g003317</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM33165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q9S5"/>
    <dbReference type="STRING" id="1365484.W6Q9S5"/>
    <dbReference type="OMA" id="ISIKCAQ"/>
    <dbReference type="OrthoDB" id="10003767at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF37">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="66"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM33165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="385" mass="43488" checksum="CE574A99C4F1E75C" modified="2014-04-16" version="1">MESMNWQTDIKHGDSLPPINWTALFDYALKLRGNQRMEVLSTRSCHIPPSYHMGGVHLVRVLEFEDGMKWVARIPLGQCTSDTKKRLLHEVHILSLLRERTEIPVPKVFGYETNGNIIGRAFMIMELIPGSTAMDAFGGWEVRNGEIPARFKSAFCRSIAEIQIAMSEIRFPKIGMIMRHAGGSYDVDSIPGIGGPFETAAEYFAAWSNTVKFPMRDINIRSRLPSHWHDEVPASIGGFPDKIKEALHILSVKNEGPFPLFHPDFRHSNVIIDGDYNILSVIDWEHAGTVPWGVVDFPLFLGVVPSPMDLPTNYDAEGNPVGEETRKIRRERNDYVQSVRDFEERGSDNSLSTILASPYIQNIATALRLYENGKLGLYCKLFDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>W6QAA2</accession>
    <name>W6QAA2_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Heavy metal tolerance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">hmt1</name>
        <name evidence="13" type="ORF">PROQFM164_S03g000322</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the ABC transporter superfamily. ABCB family. Heavy Metal importer (TC 3.A.1.210) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QAA2"/>
    <dbReference type="OMA" id="YYGAEHY"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000041">
        <property type="term" value="P:transition metal ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18583">
        <property type="entry name" value="ABC_6TM_HMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03253">
        <property type="entry name" value="ABCC_ATM1_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000186">
        <property type="entry name" value="ATP-binding cassette sub-family B member 7, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000050">
        <property type="entry name" value="Vacuolar ABC heavy metal transporter (Hmt1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
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        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
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        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221:SF651">
        <property type="entry name" value="HEAVY METAL TOLERANCE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="17"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="77"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="437"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="462"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="553"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="318"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="640"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="235"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="893"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="243"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="916"/>
            <end position="926"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDM33598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="926" mass="103053" checksum="D5272605B9C46748" modified="2014-04-16" version="1">MDPHAALELLEYLRTSYPIFLLILFVVAFVASTTIAAKKASKHESQYFGPGGRPLPQRTRSVPAYKSQEFSRNVKRVFNLLSAAILLTFLADATIYIVHVMTARSENWWRGQPFVIYVVGSFFVYAVLLMAMLDTSPSPTIAQFVCWSVAIPIELVIVSTSLSIYTSVHHEPIVGDPEGGRIRRSITLWESLEVGSNSVRILILFALVLLYACQSFSMKSHGKASQGANGVTEATGLLDSGGAENGNGNGHGNGTANGHSYGSTNGAPRPENSKPTDPWVRPTTVPSTSWWEYLSGYSLFFPYLWPSKSRRLQLIVTFCFGLLICQRVVNVLVPYQIGLITGSLTKSEGEGGDFHVPWLQICLYVLYRWLQGGQGLLSSLRSSLWIPVSQYSYMELSTAAFEHVHSLSLDFHLGKKTGEVLSALSKGSSINTFLEQVTFQVVPMLVDLVIAIVYFMVAFDVYYALAVGISTFGYLYVTIRMAQWRAEIRRQMVNASRQEDAVKNDSMVSYETVKYFNAEQYEFNRYRGAVRDFQKAEYHVLFSLTLLNTCQNTVFMMGLLIMCFICAYQVASGQRPVGKFVSLLAYMVQLQGPLNFFGTFYRSIQSALINAERLLELFREQPTVVDSPSATPLAVCNGDIKFENVEFAYDARKPALNGLTFHCQPGTTTALVGESGGGKSTVFRLLFRFYNSDNGRICIDGHDVQDVTIDSLRQNIGVVPQDTVLFNETLMYNLKYANQDATDEDVFEACRAASIHDKILAFPDGYNTKVGERGLRLSGGEKQRVAIARTIIKNPRIILLDEATAALDTDTEEHIQRALATLSRGRTMLVIAHRLSTITTADRILVLSEGQVAESGTHEELLAMKGRYASMWRKQIRAQKAMAEAQVLAERIRTATTSDDSSSSQSDEDRKVVRSLKQQNQQGPNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W6QAN0</accession>
    <name>W6QAN0_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S03</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S03g000224</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QAN0"/>
    <dbReference type="STRING" id="1365484.W6QAN0"/>
    <dbReference type="OrthoDB" id="5361958at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM33500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="107" mass="11484" checksum="B4D251EF87C28933" modified="2014-04-16" version="1">MSQISQGSWSEVDGMSSGLFSMMNIGTQTMQPKRPAGHRGIKFEEWDTRSVDFFFGNVNRAISDGVCGAPIVDVESGGVSGFFHLSDGVFAYSAVLDDLVAEGWGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W6QAW1</accession>
    <name>W6QAW1_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Homeodomain-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S03g000329</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QAW1"/>
    <dbReference type="STRING" id="1365484.W6QAW1"/>
    <dbReference type="OMA" id="IQDYEND"/>
    <dbReference type="OrthoDB" id="10249250at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13921">
        <property type="entry name" value="Myb_DNA-bind_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb-like" evidence="2">
        <location>
            <begin position="259"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM33605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="304" mass="34229" checksum="720AD50419610A1D" modified="2014-04-16" version="1">MSTAPADPYRGFMVNYTPHDSGKDANGEDIVSYGAAQLLQDRPDGIRYHSDTTQTPFGSPSTFITNHSPARQPVSHYNTHGYRLSPIQGSRKRQRTDNEPEAREDSDQNYGYRPVLQNLPMGDPSAPAGESADLTYAGHAVPSSSRQTSNQDYLQSSFPQQHHHHRLPPQASVATASAGQGSEQPPLDRSFMNLPGLPAPYPEPKAPKTRFGHREDEMLIALKEHWKFSWRQIECFFPGRKQQTLQVRYCTKLKERAVVWDDALDRKLKKALEDYEDNKWAHISRKLGPGIPPAACKLRAEELE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W6QB85</accession>
    <name>W6QB85_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S02g003428</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ustYa family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM33276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QB85"/>
    <dbReference type="OMA" id="HWNDATR"/>
    <dbReference type="OrthoDB" id="3687641at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021765">
        <property type="entry name" value="UstYa-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11807">
        <property type="entry name" value="UstYa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00035112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM33276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="81" mass="9451" checksum="560C78F89484AF99" modified="2014-04-16" version="1">MCRADTAIFPYHWNDATRLPNPTWVQKHECVNWASLEEWLESRRIDIFAPNMRVHPKYGPAYPGGKRISEPVGPKVYPLDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W6QBT6</accession>
    <name>W6QBT6_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sin3 associated polypeptide p18</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S02g001764</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SAP18 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QBT6"/>
    <dbReference type="STRING" id="1365484.W6QBT6"/>
    <dbReference type="OMA" id="EQQIFTW"/>
    <dbReference type="OrthoDB" id="440566at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.550">
        <property type="entry name" value="ASAP complex, SAP18 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010516">
        <property type="entry name" value="SAP18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042534">
        <property type="entry name" value="SAP18_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13082:SF0">
        <property type="entry name" value="HISTONE DEACETYLASE COMPLEX SUBUNIT SAP18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13082">
        <property type="entry name" value="SAP18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06487">
        <property type="entry name" value="SAP18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="136"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="210"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="52"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="231"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="255"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM31614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="277" mass="29242" checksum="88CD2E560FEF5AC3" modified="2014-04-16" version="1">MAAPSREGSKPSINRQTTAPFHLKLFYRVNNYNPLSDYSIPAPSRRGGPVSGPNSIRPTSPVASPAPLPPHLEIYTWQSCTLRELSQLLTSALPSLLPDPPVGTRLCFRLIYPDARGAAMGGPDARGRYLSRDLGSAIVGPRDSPLRADDDEDKQDARPRPGPLRFQGSEADRPLQEARFIVGDYIECAILAPLEDGSVAPALNGASGPIMGPRGGGGGGMRAFRDNGFTRGPGRGGPRGGGGGGGGGPPNLPRGDWHRGERLPEGGRGGRRGWAPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>W6QCE6</accession>
    <name>W6QCE6_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Elongation factor Tu</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">TUF1</name>
        <name evidence="11" type="ORF">PROQFM164_S03g000874</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QCE6"/>
    <dbReference type="STRING" id="1365484.W6QCE6"/>
    <dbReference type="OMA" id="EGDKEWG"/>
    <dbReference type="OrthoDB" id="2067at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070125">
        <property type="term" value="P:mitochondrial translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01884">
        <property type="entry name" value="EF_Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03697">
        <property type="entry name" value="EFTU_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000001">
        <property type="entry name" value="Elongation factor Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000003">
        <property type="entry name" value="Elongation factor Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041709">
        <property type="entry name" value="EF-Tu_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050055">
        <property type="entry name" value="EF-Tu_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033720">
        <property type="entry name" value="EFTU_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004541">
        <property type="entry name" value="Transl_elong_EFTu/EF1A_bac/org"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004160">
        <property type="entry name" value="Transl_elong_EFTu/EF1A_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00485">
        <property type="entry name" value="EF-Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000766">
        <property type="entry name" value="PRK00049.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009372">
        <property type="entry name" value="PRK12735.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009373">
        <property type="entry name" value="PRK12736.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721:SF36">
        <property type="entry name" value="ELONGATION FACTOR TU, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721">
        <property type="entry name" value="ELONGATION FACTOR TU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03143">
        <property type="entry name" value="GTP_EFTU_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9 11" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="8 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Tr-type G" evidence="10">
        <location>
            <begin position="49"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDM34150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="440" mass="48260" checksum="58674FC5A7ED2F22" modified="2014-04-16" version="1">MSSISRSLNLLARTSRSSLLRPTTVNPVHHVFSNKVTGRGLATAFERNKPHVNIGTIGHVDHGKTTLTAAITKHQASKGLANFLDYASIDKAPEERKRGITISTAHIEFATEDRHYAHVDCPGHADYIKNMITGAANMDGAIVVVAASDGQMPQTREHLLLARQVGVQKIVVFVNKVDAVEDPEMLELVELEMRELLSSYGFEGEETPIVFGSALCALENRRPEIGTEQIEKLMHAVDTWIPTPERDMDKPFLMSVEEVFSIPGRGTVVSGRVERGLLKKDTEVEIVGATDSGNPIKTKVTDIETFKKSCDESRAGDNSGLLLRGVRREDIRRGMVVAAPNSTKANNKFLVSMYVLTEAEGGRRTGFGANYRPQVYIRTADEAGDLSFPDGDMARRVQPGDNVEMILKTHHPVAAEPGQRFNIREGGRTVATGLITRVVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W6QCL6</accession>
    <name>W6QCL6_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Probable transposable element</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S03g000520</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QCL6"/>
    <dbReference type="STRING" id="1365484.W6QCL6"/>
    <dbReference type="OMA" id="QWPSMLT"/>
    <dbReference type="OrthoDB" id="9909311at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF70">
        <property type="entry name" value="HTH CENPB-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00674">
        <property type="entry name" value="CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="3">
        <location>
            <begin position="177"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="98"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="272"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="427"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="98"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="281"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="321"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="379"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="437"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM33796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="527" mass="58014" checksum="2156050A9F8995D1" modified="2014-04-16" version="1">MEEPAMETETHHEPESEFPHSPWVEIGSFASPQHSPPMHEYSGFDYGSSQLMAVDSYGMSVPPPYASMPLPMPSHSWPSMLTTHSPFVASGLPASTTPTSVSPSATMCPVRKTSTGGTTPRRTLTDDDRRQMCIYHEENKTAKQTDIGALFGVERSTVSKVLRQKEKYLNPEDGSRSPIKRAKGRVPDIERALSNWAKNLHSQGHPLSDEMIKEKALFFASICGCPEGKEKVSTAAWLEKFKQKNNLLGAKMRRGSTGIRSCSNSPIQLNTEFGSALRSPGSHSPTSSIDSFGSPLSPTSQERNKHDMAELPDLTGGYQHGYSNSTTSLDTSSAGMVSPTTPTSQSRLPFTNSDTNRLHSQTSPPVPIDPTLLSADDTTDPHRQKRELQQSLTVSTLQSPLEMDDSKPAMFPVRQTNVIKRNRSNPEITTKYMPPRSKSTTISPVSSPGSPTQDEARRALELVINYFDHQPAGLAAQEYMTIVKLMERLELARSQAGFLLSGLPRIDEHEDIHIPHVTKKRSIHNLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W6QCR9</accession>
    <name>W6QCR9_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PROQFM164_S03g001227</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QCR9"/>
    <dbReference type="STRING" id="1365484.W6QCR9"/>
    <dbReference type="OMA" id="LRWIHRD"/>
    <dbReference type="OrthoDB" id="3638488at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21742">
        <property type="entry name" value="MobB_NDR_LATS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059233">
        <property type="entry name" value="MobB_NdrA/B/Cbk1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050236">
        <property type="entry name" value="Ser_Thr_kinase_AGC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356:SF400">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE CBK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="402"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="11">
        <location>
            <begin position="817"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="22"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="133"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="221"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="855"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="29"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="134"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="169"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="235"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="263"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDM34503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="971" mass="108882" checksum="9C0B3BD377AED267" modified="2014-04-16" version="1">MTASSEKDPARRSLFNLLIPTKVVVSGKPDTSPTDSAATESPASEPIIPRGGKDRLRARLTRSGSKILLLLGLRGSSQSNKGSSVDTDCCDSVQADESTGLSNPSSPCGNGDNRPAYLTAAESVQSELLPATLLRSTPTQGVETLSKPLPDLRPPESQGESAVVDDVQQHNSSGEPLSTSVTEQPSPTNSKFVDRFSHKISLAFGQPTVIRRVHLRSRPSVLPANSPVLDGLCKQSDGANDSSSPSTSPSSGGSPAGGQSTSLTPLTSVGPSPSSDKGKLPDGHETAVIHWPSLIEINEAANASDTNVITISPSIKTVEATSVAKVYLELYFNSIFQNKDPRQQRQLELEQHIYAFELTPEERLMTRHNWVLRENDYLRQCRVLKSNRYCTQTEDAISIAGYKAIKVLGKGSFGVVRLVRRNSCDSRSSQEDDPLTLKDNNVHARSNPFGALMSAMEGARQTRRRYMTGEKKEVYAMKVIKKAEMIRNSQEGHIRAERDFLVASENSRWVVTLIASFQDANNLYLVMDYMVGGDFLGLLIRKDTLREDWTRFYIAEMILCIEEAHRLCWIHRDVKPDNFLISASGHLKISDFGLAFNGHWSHDQAYYNSHRYSLLEKLGIDVKGDSEDQEASAEAKELAPDIKLHIVDDHALHQPSSASLLDWRNNKGRRRFARSVVGTSQYMAPELIRGEMYDGRCDWWSLGIILYECLYGFTPFACENRHDTKIKILQHSRTLRFPREKFTDKLVSQDAMDLIIRILQEREYRLCSPKYQANDILNGRPVSTQLLYSMDARYRNIASYYVYPNDAADIKIHPFFRGIRWQDLHMCQPPMIPRVRNWEDTRYFDDWKLASNGVEEAVNSDSEDPDQEPHAITPENQEIRPAEDAIEPPAAKTTPGVAKEAKDTEKKKEKKRPRDKILRDKQISKTVLDIRKKGAFLGYTYRRPNDVALAFSTERGRQPYARGQLADLYAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W6QCS2</accession>
    <name>W6QCS2_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MARVEL-like domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PROQFM164_S03g000974</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QCS2"/>
    <dbReference type="STRING" id="1365484.W6QCS2"/>
    <dbReference type="OMA" id="QFACAGI"/>
    <dbReference type="OrthoDB" id="20872at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008253">
        <property type="entry name" value="Marvel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39608">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G08640)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39608:SF2">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01284">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="17"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="118"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="MARVEL" evidence="6">
        <location>
            <begin position="12"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM34250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="176" mass="19823" checksum="F2856BE461B19494" modified="2014-04-16" version="1">MVFSTNIARPLQLATRAMQWSSAVIVMGLTSFFINRGPHGQHTIYQEVIAVLSVVFFLLAFISPFLPSLSRFVLAIDVVFSYLWLTAFIFSAQDYSTRRCYFAIPAGLSCNSKRANEAFIFLAFIFTFFGIFLETAALWAYRKENTTERSYEDKVHIETRPPLDAPTVPAVPAGTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>W6QD57</accession>
    <name>W6QD57_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type DNA-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PROQFM164_S02g002275</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QD57"/>
    <dbReference type="STRING" id="1365484.W6QD57"/>
    <dbReference type="OMA" id="YNVKMLL"/>
    <dbReference type="OrthoDB" id="2571985at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000435">
        <property type="term" value="P:positive regulation of transcription from RNA polymerase II promoter by galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF15">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="30"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="91"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM32124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="665" mass="76538" checksum="6825C1A1D0BF8A7F" modified="2014-04-16" version="1">MMQNPRSPIQQPEVEQPAAKRIKRPRATQACDRCRLKKYKCNERYPCLHCKKSGWDCVYQGTYRERESSRSANYVAELEKKLEELTSKLRDTEAKASSKGPIPPAAETLCSMRNSSTPRDVPAISEAREGPREISDKQTQEFNHINTIECHSSTSPAAVIGHLKKELEPKYQEEHFSHAADYSIISTLRNPNLSPLYATGPGQMLSIEQSNYYFDQAHIFMNGYFESIHFIHPFVDKEDFFARANDLWFNRSRKPEPSFVALYLSVLSLGALVRVWDEGTLAGLGRFEWSRKLFGEAQGYLNNLRFSNDLETAQCLYMMAKVCQNELNPNLAYMYLGLAVRTCLSAGFNREIPCLGDTTERSGWISKTWWGLFSLEIEMSFSVGRPDTLGMDEYHNRSIPPRDDSEFAIIPWMIDFAQIIRQVSVQIYHSRISLQDKLQLALQIEMEMDRWLARLPEMIKPDIGGYRPSRSALRDPKWARRQRLVLGIRYYNVKMLLFRPFLSHFPRKLRHSPSELDQTFDKCLDAAMKTLQVLHDLYRVHTFFRCWWYNTTYIMLATSTLLLPMSRLGMCAETIPLLQSVEMGVEILEAMDECATSQKSVEIIRQYLRDFRASGASQPPGDDEAQSEAGQVFDVPEWAYGFGLPDYSFEGIAQLFDDMGDIPLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2024-10-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>W6QDC4</accession>
    <name>W6QDC4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S01g001413</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QDC4"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM27602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="49" mass="4838" checksum="765A98C3C82FEA46" modified="2014-04-16" version="1">MFPPACARAHAGISGCKATSADQAAKLTSSVSFRVAAHGAPGSYLQGCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W6QDF1</accession>
    <name>W6QDF1_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Crotonase, core</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PROQFM164_S01g001438</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Siderophore biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QDF1"/>
    <dbReference type="STRING" id="1365484.W6QDF1"/>
    <dbReference type="OMA" id="DPDLHWK"/>
    <dbReference type="OrthoDB" id="2139957at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000074">
        <property type="entry name" value="Enoyl-CoA hydratase (AFU_orthologue AFUA_2G10650)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="entry name" value="Lyase 2-enoyl-coa Hydratase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941:SF158">
        <property type="entry name" value="ENOYL-COA HYDRATASE (AFU_ORTHOLOGUE AFUA_2G10650)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941">
        <property type="entry name" value="ENOYL-COA HYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM27627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="287" mass="30470" checksum="92D566C55B686C0B" modified="2014-04-16" version="1">MPSFTIQPPTPAHATLTYPAPHILLVTLNRPRDLNCINAQGHADLHAVWEWLDEEPSMRVGILTGKGRAFCAGADLKEWNNRTSSAATTSSSTTPMPNSGFGGLARRKGKKPVICAVNGLCLGGGTEMIINSDIVVASSRAVFALPEVKRGVVALAGALPRLVRTVGKQRAMEMVLTGRTVGAVEAERWGLVNSVIGIGEGDGDEEIGRAVLGKALGVAGQIAGNSPDSVLVSREGVKLGWEGIGADEATAMLNDTWVKRLYEGENIKEGLRAFVEKRKPVWVDSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W6QDF3</accession>
    <name>W6QDF3_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Trimethylguanosine synthase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Cap-specific guanine-N(2) methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PROQFM164_S03g001229</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78479"/>
            <dbReference type="Rhea" id="RHEA-COMP:19087"/>
            <dbReference type="Rhea" id="RHEA-COMP:19089"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:167623"/>
            <dbReference type="ChEBI" id="CHEBI:172880"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:78480"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78507"/>
            <dbReference type="Rhea" id="RHEA-COMP:19088"/>
            <dbReference type="Rhea" id="RHEA-COMP:19090"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:167623"/>
            <dbReference type="ChEBI" id="CHEBI:172880"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="3">
            <dbReference type="Rhea" id="RHEA:78508"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78471"/>
            <dbReference type="Rhea" id="RHEA-COMP:19085"/>
            <dbReference type="Rhea" id="RHEA-COMP:19087"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:156461"/>
            <dbReference type="ChEBI" id="CHEBI:172880"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:78472"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78475"/>
            <dbReference type="Rhea" id="RHEA-COMP:19086"/>
            <dbReference type="Rhea" id="RHEA-COMP:19088"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:156461"/>
            <dbReference type="ChEBI" id="CHEBI:172880"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:78476"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the methyltransferase superfamily. Trimethylguanosine synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QDF3"/>
    <dbReference type="STRING" id="1365484.W6QDF3"/>
    <dbReference type="OMA" id="KALCIYY"/>
    <dbReference type="OrthoDB" id="194443at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071164">
        <property type="term" value="F:RNA cap trimethylguanosine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000270">
        <property type="entry name" value="RNA methylase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019012">
        <property type="entry name" value="RNA_cap_Gua-N2-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14741">
        <property type="entry name" value="S-ADENOSYLMETHIONINE-DEPENDENT METHYLTRANSFERASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14741:SF32">
        <property type="entry name" value="TRIMETHYLGUANOSINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09445">
        <property type="entry name" value="Methyltransf_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00025783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00047418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM34505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="236" mass="26537" checksum="34A9A0732AA080EB" modified="2014-04-16" version="1">MADEDAPPEVHHYSSLHEVPWDIQNYWAQRYRIFSKYDDGVWLTDDAWFGVTPEPVANTIASQIAESAPAGRSILVDAFAGAGGNTIAFALTGKWKRIYAIEKNPAVLKCAKHNAKIYGVEDKITWFEGDCFEILKNQLKELAPYSLVFASPPWGGPGYRSDQVFNLKTMEPYSLQRLYDEYSAFSKHMVLYIPRTSDLAQIAKLVPDGNKATVMHYCMEGASKALCIFYGDFNVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W6QDL6</accession>
    <name>W6QDL6_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dynamin central domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S03g001309</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QDL6"/>
    <dbReference type="STRING" id="1365484.W6QDL6"/>
    <dbReference type="OrthoDB" id="415706at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048312">
        <property type="term" value="P:intracellular distribution of mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000375">
        <property type="entry name" value="Dynamin_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566:SF215">
        <property type="entry name" value="DYNAMIN GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01031">
        <property type="entry name" value="Dynamin_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin stalk" evidence="2">
        <location>
            <begin position="29"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM34585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="135" mass="15450" checksum="AD64D8E51FC041F9" modified="2014-04-16" version="1">MAQECDPEEIRTLGVLTKPDLVDKGAENKVIDLVEGKSHSLPLGWIVVRNAAQQQLLDQSSDRDLVEARFFRENHPWSNLPKDKVGIHALKIRLQEVQTTQIRREFPKMRTDVGRKPKAMRHDLSAFGNERSTPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W6QDR8</accession>
    <name>W6QDR8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nitrilotriacetate monooxygenase component A/pristinamycin IIA synthase subunit A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S03g000950</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NtaA/SnaA/DszA monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QDR8"/>
    <dbReference type="STRING" id="1365484.W6QDR8"/>
    <dbReference type="OMA" id="HGLKEQI"/>
    <dbReference type="OrthoDB" id="5561043at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="entry name" value="Luciferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051260">
        <property type="entry name" value="Diverse_substr_monoxygenases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016215">
        <property type="entry name" value="NTA_MOA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03860">
        <property type="entry name" value="FMN_nitrolo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30011">
        <property type="entry name" value="ALKANESULFONATE MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30011:SF41">
        <property type="entry name" value="XENOBIOTIC COMPOUND MONOOXYGENASE, DSZA FAMILY (AFU_ORTHOLOGUE AFUA_3G15040)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000337">
        <property type="entry name" value="NTA_MOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="Bacterial luciferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Luciferase-like" evidence="2">
        <location>
            <begin position="38"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00033748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM34226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="481" mass="53490" checksum="566CB71529F0CAC4" modified="2014-04-16" version="1">MGEVTPTSGKKQIILNAFVMNTPGHLAPGLWKHPRNKTDQYKTLSFWTDLAQLLDKAGFHAMFIADTLGAYDVYKGPRNVVPALASGAQFPVNDPLYLVPAMSAVTKNLIFGVTASVTYEKPYALARRLSTVDHLSQGRLAWNIVTSYLDSAARNHGLNEQIPHDERYAIADEYLEVLYKLWEGSFRDDAVLADRQLGVYIASDGVREINHKGKYFDVPGPHFCEPSPQRTPFLFQAGVSEAGNQFGGKHGEAIFIGGQTPEVARLTVDNIRNIAKQQGRDPKHIKVIVGINVIVAATDEEAQAKREDYLQYADDEGALALFGGWTGIDLSSHSDDEDFLFSDSPRVQSIVRRFSGTVPGTDSLPWTKRRIVEYISVGGLQAKVVGSPTTVADELERWVEISDVDGFNLAHIVNPGTFEDIIEFLLPELRRRGLFREEIEKEGATAREVFIGSQRLPEDHTGSKYKWRAGETIPQYQTKEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W6QE29</accession>
    <name>W6QE29_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ER membrane protein complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S02g002605</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the ER membrane protein complex (EMC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the EMC2 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QE29"/>
    <dbReference type="STRING" id="1365484.W6QE29"/>
    <dbReference type="OMA" id="LMEMLFY"/>
    <dbReference type="OrthoDB" id="124397at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039856">
        <property type="entry name" value="EMC2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12760">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="157"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU367091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM32454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="332" mass="36803" checksum="39F1B3D569D13A30" modified="2014-04-16" version="1">MAGPVADIREMNGSDLISALHLAQQAPAILGQVSGSGVTSSKSSETADYYARLEQLLLACLRTGDDQSAHTCLNRLSLRFGPSNERIMGLRGLYEEATAKDQSALEKCLQEYDNTLSQSPVNVPILKRRVALLRSLNRPSDAISGLIQLLDAIPTDAEAWCELADLYQSQGLASQAIFSLEEALLIAPNSWNVCMQAPFFLFLFFSFLFQIKWSLTLKCKIHSRLGELLYICASDGDASRLLGRSVQHFSRSIELCDDYLRGFYGLTLASTRMLDNDYAGVSGQFPKKTLERLKAFALLKLGEIVESRSIDDQYWASSRSELIAAKELLNRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>W6QF50</accession>
    <name>W6QF50_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mitochondrial distribution and morphology protein 12</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Mitochondrial inheritance component MDM12</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">mdm12</name>
        <name evidence="9" type="synonym">MDM12</name>
        <name evidence="12" type="ORF">PROQFM164_S03g001406</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. MDM12 is required for the interaction of the ER-resident membrane protein MMM1 and the outer mitochondrial membrane-resident beta-barrel protein MDM10. The MDM12-MMM1 subcomplex functions in the major beta-barrel assembly pathway that is responsible for biogenesis of all mitochondrial outer membrane beta-barrel proteins, and acts in a late step after the SAM complex. The MDM10-MDM12-MMM1 subcomplex further acts in the TOM40-specific pathway after the action of the MDM12-MMM1 complex. Essential for establishing and maintaining the structure of mitochondria and maintenance of mtDNA nucleoids.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the ER-mitochondria encounter structure (ERMES) or MDM complex, composed of MMM1, MDM10, MDM12 and MDM34. A MMM1 homodimer associates with one molecule of MDM12 on each side in a pairwise head-to-tail manner, and the SMP-LTD domains of MMM1 and MDM12 generate a continuous hydrophobic tunnel for phospholipid trafficking.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Mitochondrion outer membrane</location>
            <topology evidence="9">Peripheral membrane protein</topology>
            <orientation evidence="9">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Endoplasmic reticulum membrane</location>
            <topology evidence="9">Peripheral membrane protein</topology>
            <orientation evidence="9">Cytoplasmic side</orientation>
        </subcellularLocation>
        <text evidence="9">The ERMES/MDM complex localizes to a few discrete foci (around 10 per single cell), that represent mitochondria-endoplasmic reticulum junctions. These foci are often found next to mtDNA nucleoids.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the MDM12 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QF50"/>
    <dbReference type="STRING" id="1365484.W6QF50"/>
    <dbReference type="OMA" id="KRAHFCF"/>
    <dbReference type="OrthoDB" id="3356905at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032865">
        <property type="term" value="C:ERMES complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990456">
        <property type="term" value="P:mitochondrion-endoplasmic reticulum membrane tethering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015914">
        <property type="term" value="P:phospholipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045040">
        <property type="term" value="P:protein insertion into mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd21672">
        <property type="entry name" value="SMP_Mdm12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03104">
        <property type="entry name" value="Mdm12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027532">
        <property type="entry name" value="Mdm12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031468">
        <property type="entry name" value="SMP_LBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28204">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28204:SF1">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26544">
        <property type="entry name" value="Mdm12"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51847">
        <property type="entry name" value="SMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="6" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 9" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SMP-LTD" evidence="11">
        <location>
            <begin position="1"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="183"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="351"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="211"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="353"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="364"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDM34681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="437" mass="47669" checksum="89268F08176D331A" modified="2014-04-16" version="1">MSIEVDWAAATSGPDGEALAERIRSFVHEKFQEITLPRFIRSVQVHSFDFGTIAPDLEIKDFCEPFADFYEEDDDDADTSTSDELMSELQESPYEDDMTFNPTAHSLHNFSHHPYPGEGFQPSALRSPLGDHLNPHFMPRASTPGIPGGTSTLGYHMRSLGGLSGNQTPLAAVAGGTPFASGWSDSGMGAGPRSQAARPAGTHHLAEPDLGTTNSGSRPLTANTLSSHPSLGHTGSSGSNPHTSDPTDAPQPSIEISDDPAAEHQSFPIPPRMRERRPEDFQVLCHAKYAGDVRMSLTAEILLDYPMPSFVGLPLKLNVTGITFDGVAVVAYIRKRVHFCFLSPEDADALLGSEQSQSSQNPSDDGRPRSGGDQKEKDLKRQGGLLQEIRVDSEIGRKEDGKQVLKNVGKVERFVLAQVRRIFEEELVYPSFWTFLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W6QFS3</accession>
    <name>W6QFS3_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="9">TRAPP II complex, TRAPPC10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PROQFM164_S01g002323</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1365484.W6QFS3"/>
    <dbReference type="OMA" id="YEIHANP"/>
    <dbReference type="OrthoDB" id="10256906at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990071">
        <property type="term" value="C:TRAPPII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034498">
        <property type="term" value="P:early endosome to Golgi transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055505">
        <property type="entry name" value="DUF7077"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056916">
        <property type="entry name" value="NTS_TR130"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045126">
        <property type="entry name" value="TRAPPC10/Trs130"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022233">
        <property type="entry name" value="TRAPPC10/Trs130_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056913">
        <property type="entry name" value="TRAPPC10/Trs130_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13251">
        <property type="entry name" value="EPILEPSY HOLOPROSENCEPHALY CANDIDATE 1/TMEM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13251:SF3">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23274">
        <property type="entry name" value="DUF7077"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24967">
        <property type="entry name" value="NTS_TR130"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12584">
        <property type="entry name" value="TRAPPC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23036">
        <property type="entry name" value="TRAPPC10_1st"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24965">
        <property type="entry name" value="TRS130_4HB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="TRAPPC10/Trs130 N-terminal" evidence="6">
        <location>
            <begin position="7"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="TRAPPC10/Trs130 N-terminal" evidence="6">
        <location>
            <begin position="345"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="Trs130 NTS" evidence="8">
        <location>
            <begin position="627"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7077" evidence="7">
        <location>
            <begin position="919"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="domain" description="TRAPPC10/Trs130 C-terminal" evidence="5">
        <location>
            <begin position="1242"/>
            <end position="1398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="499"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1414"/>
            <end position="1434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1425"/>
            <end position="1434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF23036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF23274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF24967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM28512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="1434" mass="158838" checksum="43B43CC3001AD7F6" modified="2014-04-16" version="1">MDPSQASSNVTVEYTDPSGLFPLIQPVIEAKLPLKNLHWKSPTRPVRSIESLRIGFVPAQESNERESSSDTVHGTVAHRRHQIPGLRQTPYLKVYLLRCDDNETYKATARRNLREWIKANASSQSSQPATTSQEKHDAFEWLILHVEPDGDAADRAATTSKWGRGSTTVLEKAKADFNGSSKSAVDRVAQLRLPKPGTKSPELAEQLEDLIDKMKNGILASFDLRVAQYEEDIKEKDSQRSLPGWNFCTFFILKEGLARGFENVGLFEDALAGYDELAVGLDAAIRDQLDGSNDQHSGALSVTSKSWSERAKKALETEVSDDSDGVEDEAALFSELQPGDFPFNANKMSYREMILASDISIFDFRTYIFSRQLTLLLRAARAPSLAGSEPAAGGNAAKSGKKPENLILLAEICARATELISLAARTLRYDLECGLAEVVHDDKADIINNLVSTWAFSAAFQILSQTSTPTLMLPESSLHAVTQSTEAAAATVADSRTNVPRRSSSLIGSPGAQPGRPVTQDISDSVGLLQRRSTMEHPKTAPILTLKTGSEQLSSGRAELLLLARRSLEEIARRRGWSENWNNLGLLFDDRYRSGASELAEISLDGDDTEESQTPKKKESSLAGIHLSGLKAALKSQDAFLFLYEELTDRLIRHHMAANRVNSVEQALAEIAIIRYRRKDYESAASYFHRMAPFYGSKYWIILEGSMLELHARCLKELKRNEDYVRMMIRLLSKFATYAQAQLSVRQKSVAGTIPSTEQEMLEGHVHDLFEASGALQKDIPASLTDFFGELRVDPAIRLYDDKDGFQIQLSLRFLLGQQIEIDNLKVRLVSANSSQNSEHWIESSAKFVVKSSTTQLLIDCSTTLQGKYFIDRLEMRAGNLVFNFNGGQDSTLPVGFRETEDSEETDNQPYIYCYPPAEALRAKIVSPHIINLQAMRTLELELHSGRNDIKSGTIRVRPGTAGLRLRLAETEVVEGTLEVDANHESGIIEFAEFPAQSFVRLRIPYTVEEAFSTLSARAEIGYETEQGRFASSASFNVVSTLPISVNVQDIFKDEILFSRFTISPAMLIPLRIMNCSLPSSDIYDVESSITGPVALDVFPKQPASLLYKIRHNEGNTIASTPRSLQLSVDFTCIDDECLDAVEKQFSASINSSPFCQYASLLTSHIVSSFRAQLSTNDMEAIGLIREVNMLPYQTVRWDDLLGALKSPGEDVRQWLKEWHKNNSTIQLPAQPTIPTRRIIIPVDVPEIPVVHTADLQLQPKATTDPGPSAHAAVGQMITAELCLRHTRRWCSPATRGNADQPLECSYEVHGNPDLWQIGGRRRGNFLARDGETKRFTVLLLPQKPGHILLPAIEIRTFLPSAPQLPTAADPAGSMAPARRSIPCEIDYRNHSETVLVLPDLKKTTVSLSAAGGNHAAGGGSWLVDSERRTEEVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W6QG78</accession>
    <name>W6QG78_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S04</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S04g000296</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QG78"/>
    <dbReference type="STRING" id="1365484.W6QG78"/>
    <dbReference type="OrthoDB" id="429143at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM35415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="71" mass="7522" checksum="364A62E029E6A603" modified="2014-04-16" version="1">MIASLPTPPAIATGSYRIAAVIGADDNALTKPQYLTAIAAIAVRAMNPTKPLTVDGKMDTMSPSWQIPLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2024-10-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>W6QGV8</accession>
    <name>W6QGV8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S04</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S04g000944</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM36063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QGV8"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM36063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="74" mass="8385" checksum="4CCE12E7EFA99165" modified="2014-04-16" version="1">MANPTEPNEPKYDTVTIFDEFNDPERRSMVELMIRRSPSLHQICWCSGASTTIDGVIRVTVDSTSHCRDARSRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W6QH94</accession>
    <name>W6QH94_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S04</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S04g000661</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QH94"/>
    <dbReference type="STRING" id="1365484.W6QH94"/>
    <dbReference type="OMA" id="MYDRYFF"/>
    <dbReference type="OrthoDB" id="2440450at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="10"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM35780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="401" mass="44480" checksum="5B68C0FB2BAC786A" modified="2014-04-16" version="1">MDPRESFPFPAAASSPATSISPTDSIPSISSIPSLTYSTSSSASIVPGTPPFTTPIIQENMASDNRNKLARTMGQLAEAGFRPVWSREHGYPGTIPEDIGEYIDSNSYRFDELIGPLSSIFWLAGLDELVDAINDPAIALEDEVRLIPTNVGVRWILEHLFEEDKLPASMYDRYFFGYNQPPVVVMPVRPDPIPLQVGYQYACHRLEELFPANRPQRLPQEISAIRVKGDNNKDRLATKIRKDYLSKLGGGSFLYRVSTRAALAAMMAFFTPVIHNSSLDNELGPGIYTSDCLEWVLKFASVNNALLVFRDPDFRNLDIWRPPMPEWQHIIATWTRKSLSNAPNSIPQEWKTADIIQAPISQPASSKNCLPEPGEVSQTVAVSYAGCGALSASLAMIIWFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W6QHQ7</accession>
    <name>W6QHQ7_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S05g000156</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QHQ7"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM36323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="58" mass="6427" checksum="AFBC472B723436E9" modified="2014-04-16" version="1">MAYVAATDFASTNRRRAFVKGKRHGVSGSPLPTHMSKLQRGQSRVGQNETLTLKQKLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>W6QHW2</accession>
    <name>W6QHW2_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">chitinase</fullName>
            <ecNumber evidence="3">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PROQFM164_S04g000901</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 18 family. Chitinase class V subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="3"/>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM36020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QHW2"/>
    <dbReference type="STRING" id="1365484.W6QHW2"/>
    <dbReference type="OMA" id="GWDEICD"/>
    <dbReference type="OrthoDB" id="73875at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00035">
        <property type="entry name" value="ChtBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06922">
        <property type="entry name" value="ChtBD1_GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.10">
        <property type="entry name" value="Endochitinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001002">
        <property type="entry name" value="Chitin-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018371">
        <property type="entry name" value="Chitin-binding_1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036861">
        <property type="entry name" value="Endochitinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053214">
        <property type="entry name" value="LysM12-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47700:SF2">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47700">
        <property type="entry name" value="V CHITINASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G13720)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00187">
        <property type="entry name" value="Chitin_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00270">
        <property type="entry name" value="ChtBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="Chitinase insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57016">
        <property type="entry name" value="Plant lectins/antimicrobial peptides"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00026">
        <property type="entry name" value="CHIT_BIND_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50941">
        <property type="entry name" value="CHIT_BIND_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="4 11" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9 12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0732">Signal</keyword>
    <keyword evidence="14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004880235" description="chitinase" evidence="15">
        <location>
            <begin position="20"/>
            <end position="1232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="740"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="774"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-1" evidence="16">
        <location>
            <begin position="138"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="17">
        <location>
            <begin position="199"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="18"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1197"/>
            <end position="1216"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="152"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="157"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CDM36020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="1232" mass="131743" checksum="28684E6039652EC7" modified="2014-04-16" version="1">MRILLPALLALASCGISQGRQQPHGKRNHAKPLPEFTPVPQLPKNSSSALPPLYQPYSKNKPKFENEALIRQLSQHPGLRLDHLDSGPGSMRKRDLPVGTCAPGVPCTNGACCSNTGVCSYAPSSCGADVCISNCDAKAPCGEYANPDNATCPLNVCCSQYGFCGSTDDFCGTGCQEGFGGCGAAPTPSCSSGSNSAAARRIGYYESWATERPCDVFTAEDLELTGLTHINFAFSYFDPSTFQISPMDGNAATLYSRFTALKAKQPGLQTWLSVGGWSFNDATNTPDTQNAFSNMISSSANRQAFITSLRNFMQTYGFDGVDIDWEYPAADDRGGVPADFSNFPTFLAELRASFGSGLGISTTLPSSYWYLQHFDVLDMEPSVDWFNFMSYDIHGVWDSSNKFTGPYLRPHTNLTEINDGLSLLWRAGVNPSKVVLGLGWYGRSFTLADPSCTTPNGVCQFTTGGTAGECTRSSGTLSNAEIKRLLAAGTGTESYDATAGVRWLTFDTNQWVSFDDGATMQQKLAFANSLCLGGIMIWSIDQDNTAGDSMNDLMGIGTANGVSEAAAASFKEQMANATLQNAVVSSCYWSLCGGACTTGYFDVTDARGQIAGFQQNSVCPPGEAQTLCCAPGTSMGTCQWEGFRGVGMPCSPACSDPKATIVARNTNSYEMNDGGQLEDLTCTGGFQAYCCTEFVPSSITNSGNLLLYGQTPVLSKRDGSNHGLSLYVGDHAVEKRSLPLLVSGLGALCLADLLPSILSAPLTFGLSLAAEGAICAATAAAVVATAAIIGFSILYNLVGWIFGGSPSKPNVGVPTTVAGRSSYGQWPILDFSGGTTTSTCDCVVTYTCRYGMGWDEICDNQRWGIDKLLNGKTVYQPLPTSRAAGANQGLWKGQRIEAYRTAAQLKLPGKTWRCQVDEFPMGNLAESGNNAPQACRLVNGPANAKQGNDYKMWKSAQWKPCSTYRSAVCNSRDSGPPATWAFGVLPAGRGSGSGKHFIDAYGFDEQTAGSLCWATYTYTEQPGTISTSTPVDHGFRVLDDDPMYGNAYGWPRQSWRIDPAPLANMADRPYDSQPTIFQRGLLANDTWPEEHSDPAGVCHADLRSLGDDKQDAYLDLDYDNLLFVDLDGKPVDGRTCNIIYEDDDPHSEVRIVLDENGKVVEIYMGDPDAGLWTREALKSSNSDKVTVDPTTVTVMTGVPAGSESRPTFPASTTGLQTRSGTVVTPAPYVYGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2024-10-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>W6QI18</accession>
    <name>W6QI18_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S03</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S03g000548</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QI18"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM33824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="88" mass="10169" checksum="1D3F88D50191FEAC" modified="2014-04-16" version="1">MEYVLRSTNCGWSRQGETQAIFSRPTDHRSSCRMGKPFLLRYFERVWGSTPELNSQFSMLTMLTILLQKCSVHFCSASRQHAVCFALT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>W6QI65</accession>
    <name>W6QI65_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Heat shock protein sti1 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">sti1</name>
        <name evidence="9" type="ORF">PROQFM164_S04g001006</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="5">Part of a larger complex that includes HSP70, HSP90, and immunophilins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM36125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QI65"/>
    <dbReference type="STRING" id="1365484.W6QI65"/>
    <dbReference type="OMA" id="MYSAREN"/>
    <dbReference type="OrthoDB" id="2423701at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042030">
        <property type="term" value="F:ATPase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.260.100:FF:000004">
        <property type="entry name" value="Putative stress-induced-phosphoprotein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000010">
        <property type="entry name" value="Stress-induced phosphoprotein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000020">
        <property type="entry name" value="Stress-induced phosphoprotein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.260.100:FF:000002">
        <property type="entry name" value="Stress-induced-phosphoprotein 1 (Hsp70/Hsp90-organizing)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000027">
        <property type="entry name" value="stress-induced-phosphoprotein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041243">
        <property type="entry name" value="STI1/HOP_DP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006636">
        <property type="entry name" value="STI1_HS-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22904:SF523">
        <property type="entry name" value="STRESS-INDUCED-PHOSPHOPROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22904">
        <property type="entry name" value="TPR REPEAT CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17830">
        <property type="entry name" value="STI1-HOP_DP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00727">
        <property type="entry name" value="STI1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0346">Stress response</keyword>
    <keyword evidence="4 6" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="6">
        <location>
            <begin position="2"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="6">
        <location>
            <begin position="36"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="6">
        <location>
            <begin position="70"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="STI1" evidence="8">
        <location>
            <begin position="140"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="6">
        <location>
            <begin position="243"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="6">
        <location>
            <begin position="317"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="6">
        <location>
            <begin position="377"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="6">
        <location>
            <begin position="445"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="STI1" evidence="8">
        <location>
            <begin position="513"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="202"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00064323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM36125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="565" mass="62426" checksum="E58D6F41B2581650" modified="2014-04-16" version="1">MADALKAEGNKAFSAKDYPTAIEKFSEALAIEPENHILYSNRSAVYSAQHEYQKALEDAEKAIEIKPDWSKGHARKGAAYRGLGDLLAAHDAYDEALKIEPGNAQAKSGMEATQRAINAEATADGVSGDPTGGLGGMFNDPALFQKLANNPKTAALLGDAEFMAKLQKIQQNPNSVGEEIRDPRFLQVMSVLLGIDMNFGGEGAEPPIPSAKPSTSQSKKEPTPEPEPVDEEAIAKKQAKEAADAEKKIGNDFYKKKQFDEAIEHYTKAWDLFKDITYLNNIGAAKFEKADYQGAIEICQKATEEGRDLRADFTLMAKAYTRIGSAHEKLGDLAQAIEFYNKSLMEHRTPDTLTKLRNAEKTKITTERNAYIDPAEAEKARELGQQKFQEGDWPGAVDAFTEMTKRAPNDPRGYSNRAAALIKLMAFPGAVQDCDEAIKRDAKFIRAYMRKGAALIAMKEYNRALDTFTEAADHDDGKHVREIEQQQQKCLDAQFSARAGETEEQTMARIQNDPDIMAVLQDPVMQSILQQAKSDPAALQEHMKNSQVRMKIQKLMAAGVIRMGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W6QID7</accession>
    <name>W6QID7_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Probable lysosomal cobalamin transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PROQFM164_S05g000023</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Probable lysosomal cobalamin transporter. Required to export cobalamin from lysosomes allowing its conversion to cofactors.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Lysosome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LIMR family. LMBRD1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QID7"/>
    <dbReference type="STRING" id="1365484.W6QID7"/>
    <dbReference type="OMA" id="FWAQFVF"/>
    <dbReference type="OrthoDB" id="73273at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072665">
        <property type="term" value="P:protein localization to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050854">
        <property type="entry name" value="LMBD1_LysCbl_Transport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006876">
        <property type="entry name" value="LMBR1-like_membr_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16130:SF2">
        <property type="entry name" value="LYSOSOMAL COBALAMIN TRANSPORT ESCORT PROTEIN LMBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16130">
        <property type="entry name" value="LYSOSOMAL COBALAMIN TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04791">
        <property type="entry name" value="LMBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0846">Cobalamin</keyword>
    <keyword evidence="10" id="KW-0170">Cobalt</keyword>
    <keyword evidence="9" id="KW-0458">Lysosome</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="144"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="312"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="346"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="376"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="416"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="506"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDM36190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="580" mass="65078" checksum="3708611C936AD0E4" modified="2014-04-16" version="1">MALLQTSLIWAVYGVVVAILLAVASVFIYVYQTPRDRSPSVTLACIISITSLLATVLLLPVDVALVSSTTSSELGQRKDWATQDVVDRITYSLTIIYYLLYSLDALLCLLVIPFTYFWYEEYDEVATEEGDQTLGQRIWGALKYTLSFFAVVVILFLVGFFVPVSRGKNDMDLDYFRRLLTENHGERALTFALGLLMTIGLCLYVLYTSVGLALLPISLIKTAPSISSATLRASTTQQLDVNQERQRQLEGRCAGDPDLLSSKDRRELDTLVREERTLIRRQRLAEESQGGGRSWLIRAWYKLGAVFRPFKLLGGVLLLFIAFLTWVSMLLTAIDKAKNSICKHRCGYILAHVNIFNPVNWALVKSARFFPIDYAIFTALVLLFFCSSVVGIAVVGIRFLWVRIFQIRNGHTSPQALLLATAMLMLIILALNYSISMIVAPQYATFGPQTFCDRAPGAFIGMPDCSNTKELIKPCSELAKNPAAQQVCTPSVVSTFLNRVTLNYPFFGVVFFWAQFFFLGLYLIVFVTSLLRSPRLDEAQLDDDAEEAEEEGLLANTGRRFNASWQDITGRATRSDRPRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W6QJE7</accession>
    <name>W6QJE7_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Major facilitator superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PROQFM164_S03g001038</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QJE7"/>
    <dbReference type="OMA" id="FCYWLMG"/>
    <dbReference type="OrthoDB" id="196103at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051617">
        <property type="entry name" value="UNC-93-like_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294">
        <property type="entry name" value="ET TRANSLATION PRODUCT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294:SF55">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17480)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="158"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="192"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="236"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="282"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="311"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="349"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="422"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDM34314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="472" mass="51299" checksum="F232CEDB5212B466" modified="2014-04-16" version="1">MSNQSVEEGRVAGTHNENRSTLFKIWTDSWFQISLISFICFCCPGMYNALSGLGGSGQVNQTVAANATVALLACTAGTALFVVGPIFDRVGPRVCLLLGGWTYALYSGSLLCFNSTNNGAFVIASGALLGVGASFLWVAQGAIMTTYVPESHKGRAIAVFWIIFNLGGGVGSLASFGINFKSTSGTVSDSTYIALLTIMAFGWALGVFICPPSYVKGAQLQITPESEKNFRHILRHAILTICNWRVLCILPLFFSVNVFYSYQQNAVNGMNFNIRTRSLNGALYWIAQMLGGLVMGLILDFPGLNRPMRARIAWVFLFVTGMGIWGGGYKFQLWSTARLDKGLKQDIDYTQGSISVGPMFLYIFYGAYDALWQSFCYWIVGAQSNSPATSAVLVGAYKTFQSVGGAMAWRINAMKKPAMTQFAMDWGLCMGSLVIAIPTVLAITLTSDVETIAVEEKDFPEMKEPEAEVVKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W6QJR5</accession>
    <name>W6QJR5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S05g000498</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QJR5"/>
    <dbReference type="STRING" id="1365484.W6QJR5"/>
    <dbReference type="OrthoDB" id="10522021at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM36665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="195" mass="22319" checksum="7573077A75B93EF4" modified="2014-04-16" version="1">MPISQSEPMSENWMDRQAGITLGNGQLRLKIHNWRTPTPTFAIENNPNGNLKCDLEAGIENSEIIRVDFRIPINYPDGMMGIMGSIEALFECPKRIAMSNIETGPAPALRESKNMERHSYHIKWTTPRETSSCQVSWMKAKEKLPTMKFKFVSGRIRRPVEQMIVTVDGRDKFYQKISKKDPVSIKPSPIFFGFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>W6QKA3</accession>
    <name>W6QKA3_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="10">UAA transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PROQFM164_S02g000161</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QKA3"/>
    <dbReference type="STRING" id="1365484.W6QKA3"/>
    <dbReference type="OMA" id="NPFTGWH"/>
    <dbReference type="OrthoDB" id="999962at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005462">
        <property type="term" value="F:UDP-N-acetylglucosamine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005464">
        <property type="term" value="F:UDP-xylose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013657">
        <property type="entry name" value="SCL35B1-4/HUT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10778:SF4">
        <property type="entry name" value="NUCLEOTIDE SUGAR TRANSPORTER SLC35B4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10778">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08449">
        <property type="entry name" value="UAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="146"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="170"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="199"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="236"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="274"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="345"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="401"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="20"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDM30012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="434" mass="46475" checksum="2A084037D670F84F" modified="2014-04-16" version="1">MLNDHEPSKGHDDSYLINRTRVSTVNQSNRNANVASPPKSRSQKSEDKLDYAQLKKDAPGLVAAAAHAAVPSWTSMVLMVSLIFGGCCANVFALEAIIKEQPTAGPLITFAQFAICAIFTIPTFLSPSAGPRALFLRPRAIPLRSWAVYTAYFMSVNLLNNWAFAYKISVPLHIILRSAGPVASMVIGYLYNGKRYSRGQIASVAMLTVGVAAAAMADAQSKGVSIHVESDAADTITTVTGFTILALAMVLSAFQGIYADRLYATYGRDYWKEALFYSHALSLPLFLTSCPQLLGQWRVVASSPSLLSHLDSGLWGSSGTVGSTAFSVLGRICHIEAVKAFLAHLPVQVAYLAMNALTQYLCIRGVHLLSAKSSSLTVTIFLNVRKLVSLLLSIYLFGNNLAGGVLVGAALVFVGGGLYGFEGARLRSVAKKAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W6QKI7</accession>
    <name>W6QKI7_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">HAUS augmin-like complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PROQFM164_S05g000768</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Spindle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HAUS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QKI7"/>
    <dbReference type="STRING" id="1365484.W6QKI7"/>
    <dbReference type="OMA" id="QAKDWAY"/>
    <dbReference type="OrthoDB" id="5372507at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070652">
        <property type="term" value="C:HAUS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026243">
        <property type="entry name" value="HAUS1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31570">
        <property type="entry name" value="HAUS AUGMIN-LIKE COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31570:SF1">
        <property type="entry name" value="HAUS AUGMIN-LIKE COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25762">
        <property type="entry name" value="HAUS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDM36935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="286" mass="32608" checksum="D0BF3A9E8D4B6169" modified="2014-04-16" version="1">MDSPLVSPAKARQAAIQAKDWAYVNSWLNRQYAPNPVPKFERNEDTLRVLLTLAAANDAADEEASLQHCAREEAVEAYKLREEFERKDPHEQVKNQLLDEVESCLDDKGRCDLEDLADSAVALGNTLNPTPGDLGQSIVELTVEEFEAQEQIAKVDTLHRYLQRELVRLQTELEELKTDVAYETPSDTQSLTSEWIRGTKTLAIKVGEYQDRIASLEKVQPRGPTIEELLAEEENVIRMRETVKALQGRVRAFHDLPKDTPGARAKYKELERELKQLRRQRDSMVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W6QKM5</accession>
    <name>W6QKM5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S05g000818</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QKM5"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM36985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="94" mass="10811" checksum="AA06B6F6AEF5AC91" modified="2014-04-16" version="1">MQLNIVDCINKSLKWKREKWRNTSFSGSGDIAHWTWTSDSMSLLYFHSTYDYRVQSKSTEYADAVQPIITILASIPATPEPTRPPIPSKVFNFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W6QKN9</accession>
    <name>W6QKN9_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PROQFM164_S02g000296</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QKN9"/>
    <dbReference type="STRING" id="1365484.W6QKN9"/>
    <dbReference type="OMA" id="SGMEYWT"/>
    <dbReference type="OrthoDB" id="444631at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF146">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="182"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="216"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="250"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="32"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM30147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="376" mass="41603" checksum="E478B11FCBFFD6A2" modified="2014-04-16" version="1">MGEAITGTFGPETIKGAGIALIVLTSLVVGTRFAGAIRSYKDLKGEDYLLIIAYIFFLELSILYIYISPVIFRLAAVGAGTIPPYATISEDGLRLQTVFFVTTSSLWLCLWMIKFSLLAMYKRLLVGKKYIIAWWVIMGFCVLFIIGCILSSWFSCSSFHAWFTAGQCNTPRDHRAAVISLYYAYGVDIATDLAIMILPIRLIWNLQMKSRQKLSIGGLFCFGWVCIIISTIRVVQLGDTENGVPAPSWLALWGTIEASIAVMIGCCPGLYRVLKAAISPSKTSYPYDSYNLRGRRGTGIPSHHSGTFRGTDIPLNSFRGKEESYQSASAYRSTSPSSSQEKLAYPSDERNIMVNYGVAVTVEDRPSDYGQTARFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>W6QL37</accession>
    <name>W6QL37_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phox/Bem1p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S05g000549</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QL37"/>
    <dbReference type="STRING" id="1365484.W6QL37"/>
    <dbReference type="OMA" id="QPIYPRQ"/>
    <dbReference type="OrthoDB" id="1594986at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000935">
        <property type="term" value="C:division septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030010">
        <property type="term" value="P:establishment of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031106">
        <property type="term" value="P:septin ring organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05992">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13246">
        <property type="entry name" value="PH_Scd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.900.10:FF:000041">
        <property type="entry name" value="Rho guanyl nucleotide exchange factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000364">
        <property type="entry name" value="Rho guanyl nucleotide exchange factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000176">
        <property type="entry name" value="Rho guanyl nucleotide exchange factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010481">
        <property type="entry name" value="Cdc24/Scd1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033511">
        <property type="entry name" value="Cdc24/Scd1_PH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053026">
        <property type="entry name" value="CDC42_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053793">
        <property type="entry name" value="PB1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000270">
        <property type="entry name" value="PB1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47339">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47339:SF1">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06395">
        <property type="entry name" value="CDC24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00564">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15411">
        <property type="entry name" value="PH_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54277">
        <property type="entry name" value="CAD &amp; PB1 domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51745">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="2">
        <location>
            <begin position="177"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="PB1" evidence="3">
        <location>
            <begin position="824"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="521"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="763"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="788"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="564"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="606"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="624"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="797"/>
            <end position="812"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM36716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="921" mass="104767" checksum="7CDD5F28AF61CCB8" modified="2014-04-16" version="1">MIDSSAMSGAPVAEDNIINRRGGESIYQSCVNLRRRLSEVPNFESYLQEMDDDDRIRGNTDPVASLWNCLRNGYPLLSIYNASGPDEPLEIDTGKVTEAKRPKAATFKFLQACLQELAFPQQDCFLITDLYGESTTGFIKVIKMVNRVVDILEMQGQLKQSEVLEAPSAKTNVKLTKREHILKELLETERDYVHHLQNLQALKKELEETGALTGDASHQIFLNLNNLLDFAQRFLIRMEQHYALPEEMQNWGHLFFLHEDAFRQYEPFIANQMRCDEACMKDWDKIQSAPRHIDLQQMVAQPKTLNGFFVKPFQRLTRYPLMLLELRKQLEDEQLQADITRAVNCIQTVLDFANEAIHKEHLTAAVLDLSERVDDWKALKMESFGDLLRFGTFQVVKGDSGKDSEREYHIYLFERILLCCKDINPNKQKSKLMMQKDKPSLNAKGKARLQLKGRIYMANVTDIVCLQKPGLYRIQIFWKGDPGVVDNFIIRYINENTMRTWYKDIDTQRVIQAERRTMRNTGTSDSEFTYMEGMPHIPNPYQQEYDTDDASNKDPYQSEFPMSRNPSSTSLRNRSATNGSSISAAHPNTRPRYAGTDPTIALHTQFPGSGSMSPGDRNVSSYFSPTTETPSTRSSSQSAGFSFSRQNTNSTTQSSVWNEDTLRYTAPALSRVTSRDGTTSGGYFPPQPIPRGAQRPSLPPLSASQSHANGMAQRMRSASSPDIHHHSNNPESRRYMGVHTMQTVDNVPVPPIPAHMANMITPVNRSQNGSPTNTQLPIRTQPQLHTTHFNEPEYNDTRNSGQISDPATSPLTQEPEEGDYMPTQLKAKVNFEDNYVTLVIATNIMFRSLTDRVDAKLARFTDRSIGSKSVRLRYRDEDGDFVTIDSDEAVQLAFLEWREQHRDMLAKGLVGEIQLYCQVVD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2016-04-13" modified="2025-04-09" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W6QM20</accession>
    <name>WETA_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Developmental regulatory protein wetA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">wetA</name>
        <name type="ORF">PROQFM164_S05g000864</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>FM164</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2015" name="PLoS ONE" volume="10" first="E0120740" last="E0120740">
            <title>The pcz1 gene, which encodes a Zn(II)2Cys6 protein, is involved in the control of growth, conidiation, and conidial germination in the filamentous fungus Penicillium roqueforti.</title>
            <authorList>
                <person name="Gil-Duran C."/>
                <person name="Rojas-Aedo J.F."/>
                <person name="Medina E."/>
                <person name="Vaca I."/>
                <person name="Garcia-Rico R.O."/>
                <person name="Villagran S."/>
                <person name="Levican G."/>
                <person name="Chavez R."/>
            </authorList>
            <dbReference type="PubMed" id="25811807"/>
            <dbReference type="DOI" id="10.1371/journal.pone.0120740"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">BrlA, abaA and wetA are pivotal regulators of conidiophore development and conidium maturation (By similarity). They act individually and together to regulate their own expression and that of numerous other sporulation-specific genes.</text>
    </comment>
    <comment type="induction">
        <text evidence="3">Expression is positively regulated by pcz1 (PubMed:25811807).</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the wetA family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM37031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QM20"/>
    <dbReference type="STRING" id="1365484.W6QM20"/>
    <dbReference type="OMA" id="MFAQPFD"/>
    <dbReference type="OrthoDB" id="2575228at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048315">
        <property type="term" value="P:conidium formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040112">
        <property type="entry name" value="WetA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22934:SF25">
        <property type="entry name" value="DEVELOPMENTAL REGULATORY PROTEIN WETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22934">
        <property type="entry name" value="PROTEIN ESC1/WETA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword id="KW-0010">Activator</keyword>
    <keyword id="KW-0183">Conidiation</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0749">Sporulation</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <feature type="chain" id="PRO_0000435930" description="Developmental regulatory protein wetA">
        <location>
            <begin position="1"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="109"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="378"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="468"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="109"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="155"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="378"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="420"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="445"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P22022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="25811807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="4">
        <source>
            <dbReference type="PubMed" id="25811807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDM37031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="520" mass="57306" checksum="CD00C5ADC2C19649" modified="2014-04-16" version="1">MFAQQYDHSFNDLFNQYVNMETSAADGKDSALSEFDQLFPLDSLSNDCGDLAPTVSTPKCHQSPQPWSNEWSLQYDGPAADHFAFHDTVHPSAISDVNLNHFEVPSRPTATHALSISPSTPPATPRRKPTQSALITPKTIRHRSPNERRSHLRKQSFSPSLMRSSNLSKSRMAYPEAWAQRLQNFSLHNSEDRLPLSPPPSDALIQHENMPTEQIMNQSRDSAEMPPQYDARLYHQSPSVPMQSPSIAMSARQQQHYIAHPSSSALTNSSPSSADDIFSLSHSSDLHSLSSWQSDSLHASSLPFTPDLQGQESQWWSPMPSRVAQQQAAYLASPTPVRHMQNVGSQNDIMQGGLMIQFNPSYDMSADHSFSSNMLPTSSQKFDTSYTSSQVHDISRSSSSLSPKTGTSPRDTHHGSISKPTHRRTHSRKLSSQSMNTPKPAKAPSSSSRGSNKSVSVSFVNFTADDSKKILTGVAPSGSSKTKARREQEARDRRRKLSEAALRAVRSAGGDVEALEAVLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W6QM44</accession>
    <name>W6QM44_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S07g000262</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792021">
        <property type="protein sequence ID" value="CDM37913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QM44"/>
    <dbReference type="STRING" id="1365484.W6QM44"/>
    <dbReference type="OMA" id="KWEMVQR"/>
    <dbReference type="OrthoDB" id="10249920at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047631">
        <property type="term" value="F:ADP-ribose diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006753">
        <property type="term" value="P:nucleoside phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019693">
        <property type="term" value="P:ribose phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18888">
        <property type="entry name" value="NUDIX_ADPRase_Nudt5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000016">
        <property type="entry name" value="ADP-sugar pyrophosphatase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11839:SF1">
        <property type="entry name" value="ADP-SUGAR PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11839">
        <property type="entry name" value="UDP/ADP-SUGAR PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="3">
        <location>
            <begin position="51"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM37913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="204" mass="22815" checksum="67C2A3AFE2B46F74" modified="2014-04-16" version="1">MTQLKSTFLSREALTSQEAKWKRLVKTNYIDPNGVKRDWESAERQTRPTDSPVDGVNIVAFLNNMNGAEILLEKQYRPPIDQVVIELPAGLIDAGETIEQAAVRELKEETGYIGVSDKTTGIMYNDPGFCNANFNMVYVQVDMSLPENQNPKPDLEDNEFIECFTLPVSELSAELQKLESEGYAIDARVGSIAEGIEIAKRLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W6QMD1</accession>
    <name>W6QMD1_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Coatomer beta' subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PROQFM164_S02g000882</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat WDR48 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QMD1"/>
    <dbReference type="STRING" id="1365484.W6QMD1"/>
    <dbReference type="OMA" id="PMWLGDV"/>
    <dbReference type="OrthoDB" id="2421129at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17041">
        <property type="entry name" value="Ubl_WDR48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001614">
        <property type="entry name" value="WD repeat protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051246">
        <property type="entry name" value="WDR48"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021772">
        <property type="entry name" value="WDR48/Bun107"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19862">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19862:SF14">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11816">
        <property type="entry name" value="DUF3337"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="20"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="79"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="123"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="186"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="212"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="345"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="579"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="858"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="985"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="605"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="634"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="660"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="858"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="869"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="996"/>
            <end position="1010"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDM30732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="1010" mass="110217" checksum="56E5059C098B7828" modified="2014-04-16" version="1">MARKLSHQRVTYVLPLPDAPGGHRLGVNGLTVDRQNSILYSAGRDGVICSWDLDFPLSSASALSSPGQKPRPTVFKTQVQAHSHWINDIVLAQDNSALVSASSDTTVRLWRPHSESTEVPERIGKHTDYVKALASPGSQATWVASGGLDQKVYLWDLNGGGEILNINAGGEDSSGKGSVYALGAVSSVLASGGPENVVRVWDPRSGKLVTKFVGHTDNIRAIMINQSGDTIMTGSSDQTIKIWSLTAGRCMNTLTMHNDSVWSLYSDHPDLSVFYSSDRSGLVAKTDMRGSADPDQGLCVAALQEHEGVVKVVAAGDYIWTATPKSSINRWRDVDITVGIEPAPDPARTIDSAAKPATPEKGPKKVPYNALLQLSATSILGGAAPKLNSSEPNLATIDLTIPVHSQPEETIEGQHGLIKCLMLNDRRRTLTQDSAGEVVLWDLLKCIPVQTFGKRHMDDVESEVNTVDSIGHWCAINVRTGRLSVILEPNRCFDAEVYADEIDLPLSELYQFRDDQRINLGKWILRWLFALVVDEEVRRDNDYRQTAIARAEENARLNPLTTSISGDDVPRSIGIPISNPHHMSTLRPSSDFPGSPNIGFGINVGTPSSNYMSTSMQSNSPFPAFEPDTPDASGLTNSHVDGGASSFSPSDYFSKRPLAAQQTDTGKSLLSPSDATPGVPQSPAEPDKEERKKSLFGKKFQMNFPKKLGRNSTETKPQILEEKVEESEISSIKEEKVYEPNLCGVVDRIRDDYEEFLATNTDRELETALSPSSEEETPRLDIPARTAVFIQEETGDTAVASDLYRGTVGRVGEDLESLKKSIPHWLGELLLKNQIPFKEQVKIAFVLKPFDDTLPPVVKPDPPAPNGAPPGNMNTNNNGSRLNANRMLRAKKVLAYVAERIDPANPDEPESVMPPEEYLELYCQKTLCPPNMTLATIRTHLWRTSGDMVLYYKTNGKKEIHPPRSLLGIDENHVLVEETHIPNGDSHAHAPPGSIHSVTNSASVAGSAIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W6QN67</accession>
    <name>W6QN67_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PROQFM164_S02g001242</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QN67"/>
    <dbReference type="OMA" id="MTIICDS"/>
    <dbReference type="OrthoDB" id="5283415at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF129">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="52"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="97"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="132"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="174"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="209"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="242"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="36"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="316"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="335"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM31092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="344" mass="37855" checksum="30831A7E1C8BAEE4" modified="2014-04-16" version="1">MSSSKYPSSFLAENRRQPAIIGMVVVTTLSLLVVLIRLYARGHLIHELGWDDLTIAVAQLVSWIVLGLSLMVIHYGSGQHLAALMNDPEALVHMYKWLVGAQLVYMFNMWLCRISGIAFYARLNQMPRFTLYLRISFAFVTAVYVAQTLIITLQCVPLAVLWGGAEGECMGSEIVFISTSVLTIVCDSLVLLLPMNIVFSLKAKLARKLVLALVLCVGVFAVVTSILRMVSMIVALQHPDDATWYFSVVMVWSATEISAAIIALSLPALRAFFGVLSRNRSTMHHSDSDNIGTIGLESIPLSAREPVSDGHDVHETTIDVDWGTSPSQETLWGVKDGEYGSHGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W6QPB1</accession>
    <name>W6QPB1_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein kinase-like domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S07g000174</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792021">
        <property type="protein sequence ID" value="CDM37826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QPB1"/>
    <dbReference type="STRING" id="1365484.W6QPB1"/>
    <dbReference type="OMA" id="ELRCMDL"/>
    <dbReference type="OrthoDB" id="3250044at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF39">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="44"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM37826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="274" mass="31005" checksum="776DFABC16C30698" modified="2014-04-16" version="1">MSDAAMTVQLDNNQSIIDYCRSCPEDQLTGGLRSGNQVVKLPDCDLVVKFGPFVSSHEAKNQQKAYSIINLDIIIVPSVHNFFMDDEGWGYIISDFIQGKIIDNLSDSHIQRLAYILEYFHSITADRAGSLCGGPSIGLLWPDTNNLTISNVQQVEEWFNSRLFPGDGKVHFDPTPLVLCQLDIAPRNIIWLDDGRVCLLDWASAGFYPRLLEFASLFCQEYCFSEMLLKAVGFDYGRDKEQQQRIYKALYNNERYSFWLHLSSSITSGTAKTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W6QPK2</accession>
    <name>W6QPK2_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Major pollen allergen Lol pI</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PROQFM164_S04g000910</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM36029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QPK2"/>
    <dbReference type="STRING" id="1365484.W6QPK2"/>
    <dbReference type="OMA" id="IIQTTWS"/>
    <dbReference type="OrthoDB" id="406505at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22271">
        <property type="entry name" value="DPBB_EXP_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.760">
        <property type="entry name" value="Expansin, cellulose-binding-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007112">
        <property type="entry name" value="Expansin/allergen_DPBB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036749">
        <property type="entry name" value="Expansin_CBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051477">
        <property type="entry name" value="Expansin_CellWall"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049818">
        <property type="entry name" value="Expansin_EXLX1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009009">
        <property type="entry name" value="RlpA-like_DPBB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041144">
        <property type="entry name" value="expansin_EXLX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836:SF21">
        <property type="entry name" value="EXPANSIN-LIKE PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03330">
        <property type="entry name" value="DPBB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49590">
        <property type="entry name" value="PHL pollen allergen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50842">
        <property type="entry name" value="EXPANSIN_EG45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004879751" evidence="3">
        <location>
            <begin position="21"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="domain" description="Expansin-like EG45" evidence="4">
        <location>
            <begin position="313"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="253"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDM36029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="501" mass="50286" checksum="494288A7A9AF2314" modified="2014-04-16" version="1">MKYLQLASVAALLSAATVSAGPLRAREDDGFCPKGYTMSVYYKTITVDTYSSATSVETAVTPTATPVSIESQPSAEPTVASSSTAVAVVSSTPVAVVPVETTSSAPAAESAVVETLTSLVSPTPVAPVETTSSSVSTVESTVVPAETTTSSASATPVVPVDTTSSSAVESAVVETLTSSVSSAPVAETSIVPVETTSSSTSAAETAFIQKAASKTDSVVVTASTETAAVVQTIAAPVVKSAAAQTSTTQAAVEATSTSTTSIVSSSTTTSSVTSSSTTSSSTSSSAAASSTTSSSTVSVSLGASIAGEATFYGGNVGGGTCSFSGYTLPSNLFGTALSLQRWDDAANCGTCVSVTGPSGNSITAMIVDQCPECESDHLDLFHEAFAELADTSLGVIETTWSYVSCDLDGPLQLKNKDGTGPYWFSMQVVNANEAVTALDVSTDGGSTWQGTTRTYYNFFEYDAGFRTSTVDVRVTGASGNTVIVQDVAVVSGTSVTAASNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W6QPZ1</accession>
    <name>W6QPZ1_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S14g000009</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792028">
        <property type="protein sequence ID" value="CDM38510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QPZ1"/>
    <dbReference type="STRING" id="1365484.W6QPZ1"/>
    <dbReference type="OMA" id="RDHACAS"/>
    <dbReference type="OrthoDB" id="6417021at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM38510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="81" mass="8600" checksum="3068DCE80DC0AF25" modified="2014-04-16" version="1">MAAMIMRVFTAFGPPKVEKKNDAIRFGILGAAQIAPLALITPALSHSEVIVQAIAARDHACASAFSKSRTSPAFAHPTRVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W6QR31</accession>
    <name>W6QR31_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S05g000362</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QR31"/>
    <dbReference type="OMA" id="FGIEWNI"/>
    <dbReference type="OrthoDB" id="4362322at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM36529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="292" mass="32777" checksum="AC129967A02EFF43" modified="2014-04-16" version="1">MSQCQKGISLLFRHEGYYEIACSIMEQLTASDVGALLASLRITPAQHTVETFLQPLRDFDPTMRQFESWFQDKCQILIIGPDTIRLSDRIFNADEYYKGKRPSQTQLEVWIFAIPANFEKSAKEVQCLRHCSHASSLFSMQERAEALIAGQELLENNLIRQISYTDAEPSKVPGEYLDVKIFDLFSTTTHRRERPSASSKTPKPGILPRVPGLGSTVNGFYPYQLVLNSCVLSQQRKYLGLDDTDPIAVDTEPETSRFQGRGLKALQAIRLPAGVPYNSTARLATGLRATDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W6QRA8</accession>
    <name>W6QRA8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Probable transposable element</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S14g000010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792028">
        <property type="protein sequence ID" value="CDM38511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QRA8"/>
    <dbReference type="STRING" id="1365484.W6QRA8"/>
    <dbReference type="OMA" id="WICTHDA"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47662">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47662:SF1">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
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        <location>
            <begin position="21"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM38511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="108" mass="12672" checksum="54677E21F121DCC7" modified="2014-04-16" version="1">MRPKPVISRANTRQAVTIQICTICLGDMSSRSIFRQLPCQHLFHKPCIDKWICTHDASCPLCRMTFYHLRRPFLVSESVAMSLGCEQDELQRGRDIFILWWRKLFCLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W6QTU2</accession>
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        </submittedName>
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    <gene>
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    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QTU2"/>
    <dbReference type="OrthoDB" id="4246676at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM32957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="87" mass="9666" checksum="E001A482648CE834" modified="2014-04-16" version="1">MTTAQNRSPRYNKLSGMEITGFMVFSASSNGADINSEVKRSLHLWPKIEKAPLVYGRGDTDTYTRFLQRGTEESDVVGLPKSILNQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W6QWE1</accession>
    <name>W6QWE1_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S12g000083</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792026">
        <property type="protein sequence ID" value="CDM38474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QWE1"/>
    <dbReference type="OrthoDB" id="4360605at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM38474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="66" mass="6882" checksum="6181039941DF574B" modified="2014-04-16" version="1">MAHNSKSSGNSAGRGAAKVKPRAGRLCTDSPYSDRSTVPTSKVDCDPLKPVAKLYKGLGYSVIKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W6R0F4</accession>
    <name>W6R0F4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S04</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
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            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
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                <person name="Renault P."/>
                <person name="Dupont J."/>
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                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6R0F4"/>
    <dbReference type="STRING" id="1365484.W6R0F4"/>
    <dbReference type="OMA" id="QATRATW"/>
    <dbReference type="OrthoDB" id="4220319at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42090">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR42090:SF1">
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="54"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="71"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM35272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="203" mass="22558" checksum="167C7233A7D28890" modified="2014-04-16" version="1">MILGSRELGTQRRVTDYFSFPLIHFTTTYILQFRYPSSTTTRYLMWKTIISAGQQATRSQVPKPTIQSLATPTATRTPFSTTPISQIEKGQGPLDRETLNPERSETAKSGTDGEVAKHPSSFDPTNTAPESELAANEKESRQEGKKSPLDMSPANRDASAWRTKEEDGPVRNQDRGVSSSRGTPNKARSIHVKEDGTHVSYRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W6R1S6</accession>
    <name>W6R1S6_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S04</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S04g000638</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
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            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6R1S6"/>
    <dbReference type="STRING" id="1365484.W6R1S6"/>
    <dbReference type="OrthoDB" id="4492013at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM35757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="102" mass="11158" checksum="A7F9DA1175E19ABE" modified="2014-04-16" version="1">MAAACGRMRSRCEDGVLPFLAIMIAAMGEGEAPVLHAEAEAFATQRDYRFVKFSPATGRGICNTVSSLVELVHGARDKYSIDQEGYTQRYKRAEALQTLSPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W6R3A5</accession>
    <name>W6R3A5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F-box domain, cyclin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S05g000105</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6R3A5"/>
    <dbReference type="OrthoDB" id="4510091at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM36272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="67" mass="7819" checksum="07269717666AE828" modified="2014-04-16" version="1">MTIFADLPFELLRLIVVDLDYYSLRSFSLVNRRCRSVSTLDIFYIFKVEFTEKGIKKLKGLAISLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>W6R5V0</accession>
    <name>W6R5V0_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Tyrosine--tRNA ligase</fullName>
            <ecNumber evidence="3 12">6.1.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 12">Tyrosyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PROQFM164_S06g000148</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>tRNA(Tyr) + L-tyrosine + ATP = L-tyrosyl-tRNA(Tyr) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10220"/>
            <dbReference type="Rhea" id="RHEA-COMP:9706"/>
            <dbReference type="Rhea" id="RHEA-COMP:9707"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78536"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.1" evidence="3 12"/>
    <dbReference type="EMBL" id="HG792020">
        <property type="protein sequence ID" value="CDM37187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6R5V0"/>
    <dbReference type="STRING" id="1365484.W6R5V0"/>
    <dbReference type="OMA" id="RKIHMLA"/>
    <dbReference type="OrthoDB" id="197206at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004831">
        <property type="term" value="F:tyrosine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006437">
        <property type="term" value="P:tyrosyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000040">
        <property type="entry name" value="Tyrosine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.240.10">
        <property type="entry name" value="Tyrosyl-Transfer RNA Synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002307">
        <property type="entry name" value="Tyr-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023617">
        <property type="entry name" value="Tyr-tRNA-ligase_arc/euk-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050489">
        <property type="entry name" value="Tyr-tRNA_synthase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006330">
        <property type="entry name" value="PRK08560.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00234">
        <property type="entry name" value="tyrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46264:SF4">
        <property type="entry name" value="TYROSINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46264">
        <property type="entry name" value="TYROSINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006588">
        <property type="entry name" value="TyrRS_arch_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01040">
        <property type="entry name" value="TRNASYNTHTYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12 14" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 12" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="350"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="355"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDM37187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="378" mass="41974" checksum="2B62D162F1BA37A7" modified="2014-04-16" version="1">MALSAEERFDLIRDNLGEILNPELIESILAEGRNPRVYWGTATTGRPHSGYFVAAIKIAQLLASGCEVVILLADVHAFLDSMKAPLELVENRVKYYEKIITAVLEAVGVSTEKLEFVLGSSYQRSSDYVMDVYRLAAMTSEHDCRKAGAEIVKQSTNAPMSGLLYPILQVLDEEYLKVDAELGGLDQRKLFTAATEWLPKLGYRKRAHLITPMVAGLSGGKMSSSIEDSKIDLLDPPEIVAKKIRKSEAVPRVVENNGIIAMVEFVLLPAAALAGKKEFRVARRDNEPLIYTNIQQLKDDYTNDVLTPQDLKPAAAEALTRLMAPIHKAYADSPEWQEITLKAYPPPVVQKKEKKVKDRGSRFPGANKEKDIPERPKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W6R6U4</accession>
    <name>W6R6U4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Major facilitator superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PROQFM164_S06g000519</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792020">
        <property type="protein sequence ID" value="CDM37557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6R6U4"/>
    <dbReference type="OMA" id="ITFCWIR"/>
    <dbReference type="OrthoDB" id="6499973at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17352">
        <property type="entry name" value="MFS_MCT_SLC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF281">
        <property type="entry name" value="ASPYRIDONES EFFLUX PROTEIN APDF-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="129"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="196"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="239"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="274"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="304"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="329"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="364"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="393"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="5">
        <location>
            <begin position="37"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDM37557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="426" mass="45817" checksum="BCF349F495D7FA26" modified="2014-04-16" version="1">MSTSQLSNDRATPSSSEAPDRVELEKPTPKFPEGGLRAWMVVLGAFCVSFSTFGYMNAFGVYQDYYTEHFLSNETSSTISWIGSVQVCFLFAGSLIGGPLFDRYGAVVIHIPAVAIVFSVMMTSLCKKYYQFMLAQGVLGGIASGMLFAPVMTCVSHYFHTRRAAALGVTVSGSSIGGVIFPIALSKMLRNESLGFGWSVRIVGFIILFMVLIAMITVRERLPPRSGKVLLPRAFARAPYTLVTLGIFFMMWGLFTPFFYLPQYAQSYGMESQLASYLLSILNAASVFGRILPGMVADKIGRYNILIITGVCSGILLLCWIATTSNASIIVFAGLYGFFSGGIVSLMSPCIAQVTPSPDQIGTHLGMSMAIIALAGLTGTPICGALLERYGGYTQAAVFSGVVMFFGSVLVAAARFCLQAKPLAIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W6R8Z0</accession>
    <name>W6R8Z0_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein kinase-like domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S10g000106</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the choline/ethanolamine kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792024">
        <property type="protein sequence ID" value="CDM38292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6R8Z0"/>
    <dbReference type="STRING" id="1365484.W6R8Z0"/>
    <dbReference type="OMA" id="CEQVINW"/>
    <dbReference type="OrthoDB" id="10267235at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004103">
        <property type="term" value="F:choline kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004305">
        <property type="term" value="F:ethanolamine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05157">
        <property type="entry name" value="ETNK_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007521">
        <property type="entry name" value="Choline_kin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22603">
        <property type="entry name" value="CHOLINE/ETHANOALAMINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22603:SF93">
        <property type="entry name" value="RE24176P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04428">
        <property type="entry name" value="Choline_kin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01633">
        <property type="entry name" value="Choline_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Choline kinase N-terminal" evidence="3">
        <location>
            <begin position="135"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="104"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="538"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="12"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="39"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="74"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="114"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM38292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="679" mass="77261" checksum="AC9D7D13F3E65EC0" modified="2014-04-16" version="1">MPSLDDLSTLILREDQEHPRSEEDSQGLFQQVHEWLHHEKARRQNRKARKAEATSHATNENESTEENAVLERPSSNTSNTSNTSENTFSLDKLERILLQYATARPRSALGSHRQPVKRQSRHRLRGLRRGSASESELTDADGAPPSVEASLDNTKTLAYTGGTAVEENTDSSACVKQGKDAEAWVVFKSEIVRLVHTLQLKGWRRVPADLASEIEVVRLSGALTNAVYVVAPPKNLPPSKTDSNSLVSRKRPPKLLLRIYGPQVDHLIDRENELQILRRLGKKNIGPRILGTFTNGRFEEYFEARPLTPKELRMPETARQVAKRMRELHDGVELLEEEREGGPMIFKNWDKWVDRCEQVMNWLDKEIESPQNEAKAASEPWRRRGYVCGVTWDVFRRAVDNYRLWLVNSSGGMAEIKRQLVFAHNDTQYGNLLRMEPATESPLLLPANEHKQLIVIDFEYSSANTPGLEFANHFTEWCYNYHDEERSWACNNRNYPTSEEQYHFVSTYLTHRPSSSGALISPLSSPTIRARPPVALAPLDLDEGSDRPSSRLSQNEQSKEAELDAEVRFLMKQTRMWRAMNSAQWVAWGIVQAKVPGMEEGIAEMLAARNGPSDGNDDDTKTPPAVDIEEEDDGDFDYLAYAQDRVMFFWGDLLSLNLIKPEELPAPLLEHIKSRLVTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W6R990</accession>
    <name>W6R990_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Probable transposable element</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PROQFM164_S12g000031</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792026">
        <property type="protein sequence ID" value="CDM38422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6R990"/>
    <dbReference type="OMA" id="HASRECC"/>
    <dbReference type="OrthoDB" id="4362013at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="346"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="78"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDM38422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="411" mass="45683" checksum="391270CE3281683D" modified="2014-04-16" version="1">MSDPPTGGPEPFPTNTQETITSIPGEELQATAAADSPGLLSESRKRTRSGDVFAPADPAARITTKEVWKLIGTLKDIIRRQTAAIVATQDELQEIKHNQNVLQEQNEKLHEEVKALRAQVENTPPATATRTWATVAASGGNDTSPLNHPKPEKEQNCIRISTQRTFVDPRDSNDNDGNAFGRYLPIDAANNHIRTALQSEAATQDVQVAGVGTTKTGYIIRFKNTESTEAARSNTEWLHQLGNNTKLVKPRFGVVVHRTPTEEFDLETGATQAVEKIIEDNDLAEHGFRIEELAWMKAKDKTLGKFASLGIWFDSAEGADHMLREGFLVSGNFIHQVERREIKRKRCFRCQRFGHLAWTCKEMPRCGHCAGQHERERCPPGVRARCLDCSGEHPTGYRQCPAPATFNPTRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W6PR48</accession>
    <name>W6PR48_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Probable transposable element</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S01g000030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PR48"/>
    <dbReference type="STRING" id="1365484.W6PR48"/>
    <dbReference type="OrthoDB" id="4737581at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM26221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="155" mass="17715" checksum="A471DAEC737D1806" modified="2014-04-16" version="1">MVPSRGKQVKRMFWAAFCGQPRRSGLIPLDGDPEAPRCGVSSRTIDELYRRVLPTLVHNVHYAIFQHDNAPVHTAYLVWDTLNELGFEALLKAELLKRHPELKYLSNHEATLDLLLDAAQEVWEGLDIDIFAHLSETMPHRVADVIKYGGWHTSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W6PRJ5</accession>
    <name>W6PRJ5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g000299</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PRJ5"/>
    <dbReference type="STRING" id="1365484.W6PRJ5"/>
    <dbReference type="OMA" id="PRNNMDN"/>
    <dbReference type="OrthoDB" id="2873061at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35587:SF4">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35587">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="137"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM26490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="232" mass="25646" checksum="7EE06B4569C475AF" modified="2014-04-16" version="1">MSDQEQPPTPNPDSTNTTPNKPKRAPPKLGKKSPAKQEQTPPSSEQDQDQDQDQDKQPKEDEPKPEEPAKQQDPESEPEPEPEQEDQPEPEPEPQPKPERRRRRPRPRPQESDTESIARSEMEPEPRPQRRVRRQRQPQQQQQNDSPLGGLPGVGGVDQAGQLVQNTAGNALNGVTGSAGKAVGGVLGGGEEKKDDDGGRDEQLRLRLDLNLDIEVQLKAKIHGDLTIGLLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W6PRM3</accession>
    <name>W6PRM3_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PROQFM164_S01g000329</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PRM3"/>
    <dbReference type="STRING" id="1365484.W6PRM3"/>
    <dbReference type="OMA" id="VWTCIEA"/>
    <dbReference type="OrthoDB" id="5378633at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="60"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="139"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="182"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="256"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="44"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM26520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="348" mass="38984" checksum="E78A805ED996F40A" modified="2014-04-16" version="1">MSSPDSSSPTWTPGDFEHPNQELRRSMIIALVFAYTLSTLSVALRILARKVTGSRLFMDDYLIMVALFFKYACSSGVVVLLFNGMGSHITMIPAKNLVVYFQLGFANAFIYTGCIAFIKYSILALYRRLFAVRHMTIAVNIMFGFVTLWVVGVYVAGALLCIPVKRFWDQSVEGACLDPAKFYYGIQIPNILSDIILLIMPMRVVWTLPISNGQKALLSGVFLVGGLTLIFDIFRLNAMIRLVELGPDITYNQVPVIVWTCIEAAVGITAACLPNLRPLFKLSHRNFWSQIRASNNVSELSDRTLVVSSNPGGTITSNHKQSVSYAVRQTFEMPRYEDYKDEKPRESV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W6PRY0</accession>
    <name>W6PRY0_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S01g000777</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PRY0"/>
    <dbReference type="STRING" id="1365484.W6PRY0"/>
    <dbReference type="OMA" id="ACALYMR"/>
    <dbReference type="OrthoDB" id="4369808at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="224"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM26968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="421" mass="44689" checksum="E87ABC2FA687C385" modified="2014-04-16" version="1">MSSASSAIDTPSVPLNNFTQTLSPRLSSGPLNLVTVTSIETQTVHPTWVYTISESGTDSSTAASVLDFLSLTLDLTPVTVTLATTTQWTIKQDTTITAPDISEPPISTLIPTTSVLPSQMGVSATSESSDHHSWHSDAPGSVWIPPVPLTSPSISLSSSLPILPETATSSVSSTSSISTLASLSTAPSNSHSIPPSIGTATVADSSETSQADNLSSASSKIGTIVGSIIGGSAIMIFALLACALYMRHRRRRITTERLGLRQKLIRGDSTSSSISHHFHRYHSYPSIPGNIGPRSPILPVIPLQQQPSNPDLSLDSMYLRGETAQEAFTNPPSAIIEISAPSRSVSLYSTSSRDAGLREQGHWDCERAGTDSLAVPHGYLDASMMRDSMRSDPFDLDLEPPPNAHHRSSVPSIPTMWAVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W6PS48</accession>
    <name>W6PS48_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g000385</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PS48"/>
    <dbReference type="STRING" id="1365484.W6PS48"/>
    <dbReference type="OMA" id="DAWEYTW"/>
    <dbReference type="OrthoDB" id="4802432at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004881535" evidence="1">
        <location>
            <begin position="22"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM26576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="497" mass="57767" checksum="12390EE77B922CF4" modified="2014-04-16" version="1">MATSLPLELLFEIATLLRIDGASLIPCAYVCRYWQAALEPLIYANLAVYSDSYHKEEGQRGISLTHFQKLTSGSRSIRRNWIRKLEYDIIIPCKIFDWTTSENSKYSADNQLRQANDFAFQTAMFDLFQTLHSWSQHCRLTLHLGLRGSQHIRWPRMEPDTLPCPTASAALSFDYRGRRHIPIPPYRARFINNLSELYLAHVQCIDKLSFLNQNFDRNRHHQIWTGTVQTIIQHCPTITELELDLNEWVRPDYLQYIQRRRASLASLLGVIPDSLRVLHYNGSEDGPWKHSLPGLNVIPSGIDSLAINLRNLSVHLRELKLARTTLPFDFLCPLDGKGQPIIGSLHWPYLKTLEIQDVPPWLPCGQWTSNHTVEYRAKIENDNWNDRIHDAERRWNGTSVMNDEQFHRLLISLGYATQRMPCLKRMTFRMECYCRFSLHLHNHSNASTLEWQSRAGYQPDSRVAKAWKFDLDDLRIDSSPLGICSVILPRWPPDEPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W6PSE9</accession>
    <name>W6PSE9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pyoverdine biosynthesis</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g000574</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PSE9"/>
    <dbReference type="STRING" id="1365484.W6PSE9"/>
    <dbReference type="OMA" id="SMTPWHC"/>
    <dbReference type="OrthoDB" id="429813at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007817">
        <property type="entry name" value="Isocyanide_synthase_DIT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37285">
        <property type="entry name" value="SPORE WALL MATURATION PROTEIN DIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37285:SF5">
        <property type="entry name" value="SPORE WALL MATURATION PROTEIN DIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05141">
        <property type="entry name" value="DIT1_PvcA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM26765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="440" mass="49838" checksum="3DF6B6035C6AE77A" modified="2014-04-16" version="1">MSYIKMLATTVVKVSPHLDIIPFDCITPVPKKRASFLPKPQPVASKPETTTDTHLDPPAVCSTLARLKAEEIMNIVERYGSHERTTTAGEWLGRSSFTPRVQTHVAANRAIPMVLPAFPMKSNNRMDKVLGSLPDLGDELGLARLVNLCRDIKAVYPPGAVVVMVTDGICYNDLTGISDEEVWEYGNRLRKIAVEKGYACIQFHRIMNMLGLYTSAHISKSDYVKLCGLSRAELHRRCGRPGFDVDKFLKNDEDYLRTYNGYDKFMKVDLKFSPVTKDCAGPKQYKRRIKIIAKAMIVRGVEYAELVRQVYPDSLRLSIHPSSGQTKLSCPLIPQKNSFSMSPWHCSVAVTTTGEFITAHQSVHRQKFDLIRKDGQPYFFRESSLLFNWDARVDFEHHYGQKLVVKAQKQIDQELSDSDLDKLALLAIQQRSVSFVFVYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2024-10-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>W6PSG0</accession>
    <name>W6PSG0_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S01g000584</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PSG0"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM26775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="34" mass="3923" checksum="79DCF17C1B027F91" modified="2014-04-16" version="1">MQLLLVNGSYWLLLNVDKEDNSGTIERVLSLFLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W6PU03</accession>
    <name>W6PU03_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FAD dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PROQFM164_S01g001149</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MSOX/MTOX family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PU03"/>
    <dbReference type="STRING" id="1365484.W6PU03"/>
    <dbReference type="OMA" id="VWNPTAG"/>
    <dbReference type="OrthoDB" id="2219495at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051698">
        <property type="term" value="F:saccharopine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008115">
        <property type="term" value="F:sarcosine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045170">
        <property type="entry name" value="MTOX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961:SF37">
        <property type="entry name" value="FAD DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961">
        <property type="entry name" value="PEROXISOMAL SARCOSINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="6">
        <location>
            <begin position="7"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM27340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="432" mass="47814" checksum="CDCE0407333163B0" modified="2014-04-16" version="1">MMEKDTRILIVGAGCFGISTAYHLSQRGYTSIRVLDPYAPPSCEAASTDISKIIRSDYNEPLYARLGIESIEAWRSWPLFRGLYHVPGWILSAANLSRPFVEGSIETCKKLGVQGLEKLTPDQIRARWSVVTGKLDGWNINVWNPTAGWAASGTAIERMAGAAQEKGVEYISGDTKGRVQELILDDITGECKGVVTADGTRHEADVVILAAGAWTPSLLDVKDQLTAKGHSVAHIQLTPSETKHYASMPIMDNLELGYFFPPLEDGIFKMAHSQFITNVQTTKSGITTSVPHTFVQAPTDGLPLEIEAQMRRNLRRVFPELADRPFCYTRLCWDADTADRHFLVTPHPTHQSLFLATGGSAHGFKFLPVVGKYVADLLEGTLDPDIVRQWKWRAGQKSTAKNLAHLDPEMELSDLTGWKGRHAHERSHASKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W6PU25</accession>
    <name>W6PU25_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g001529</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PU25"/>
    <dbReference type="OMA" id="RYEETAY"/>
    <dbReference type="OrthoDB" id="5401654at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39610:SF1">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39610">
        <property type="entry name" value="BZIP DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="263"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="107"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="126"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="146"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM27718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="286" mass="30887" checksum="77CAC9FD976A8EBC" modified="2014-04-16" version="1">MAPDLSAASDSTMAQPPAATTAPAMASQAPTSRQPVHSSHTSVTLPPPGSPPLGTGDYGITRTAQEQGPLRHPQPLTPSDLHLVLEKEQEAIVNRLTRELSILRQQTASVASTTSSTSTFNEADGARASPALSSSTPSHSARRNRSNSSLSSHTSASQGQQSASVTGIAPSRDIQYRPDHSRTVRSREPSLTSRRPSMGSLSSFPHNSNIYPQRSSVSQTQQGHSPGNSLSRFEEAAHHKLEVEYMKRENEQLRRRVRDLEQTLKRQKEDSASEASATPSERIIEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W6PW16</accession>
    <name>W6PW16_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Stigma-specific protein Stig1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S01g001787</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the STIG1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PW16"/>
    <dbReference type="STRING" id="1365484.W6PW16"/>
    <dbReference type="OMA" id="CKDACKC"/>
    <dbReference type="OrthoDB" id="4506138at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006969">
        <property type="entry name" value="Stig-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33227">
        <property type="entry name" value="STIGMA-SPECIFIC STIG1-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33227:SF48">
        <property type="entry name" value="STIGMA-SPECIFIC STIG1-LIKE PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04885">
        <property type="entry name" value="Stig1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004879225" evidence="3">
        <location>
            <begin position="20"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM27976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="276" mass="27338" checksum="1F8B9205DAB2B774" modified="2014-04-16" version="1">MLAFLLLGVLGSFYDHVKAGTQPACCSGVCTDLDNDVASCHACNITCTSEAPTCCSATCTNTAIDPDTCGLCGSKCTGTNPACCNGICTDLSTDPAHCGPCLASSCTGVNPACCSGTCVDLNSDTNHCSSCSALPCGGAQPGCCFGQCTDLFTSLQHCGSCTAAPCPGLLPACCDGACTDLTTDAKHCGSCSTACNLGPGGGGCVGGNCISCPTNQPFCQSSNTCCPGGFTCINNGPLPGCCGPLNVCPPLSNYLGDSICVSDALDSTDRLSDQGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W6PWG8</accession>
    <name>W6PWG8_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Choline monooxygenase, chloroplastic</fullName>
            <ecNumber evidence="5">1.14.15.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PROQFM164_S01g000083</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the first step of the osmoprotectant glycine betaine synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>choline + 2 reduced [2Fe-2S]-[ferredoxin] + O2 + 2 H(+) = betaine aldehyde hydrate + 2 oxidized [2Fe-2S]-[ferredoxin] + H2O</text>
            <dbReference type="Rhea" id="RHEA:17769"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15354"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15870"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="EC" id="1.14.15.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine aldehyde from choline (monooxygenase route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the choline monooxygenase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.15.7" evidence="5"/>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PWG8"/>
    <dbReference type="STRING" id="1365484.W6PWG8"/>
    <dbReference type="OMA" id="YAFILVK"/>
    <dbReference type="OrthoDB" id="426882at2759"/>
    <dbReference type="UniPathway" id="UPA00529">
        <property type="reaction ID" value="UER00430"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019133">
        <property type="term" value="F:choline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019285">
        <property type="term" value="P:glycine betaine biosynthetic process from choline"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00680">
        <property type="entry name" value="RHO_alpha_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03469">
        <property type="entry name" value="Rieske_RO_Alpha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.380.10">
        <property type="entry name" value="Naphthalene 1,2-dioxygenase Alpha Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="entry name" value="Rieske [2Fe-2S] iron-sulphur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015879">
        <property type="entry name" value="Ring_hydroxy_dOase_asu_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001663">
        <property type="entry name" value="Rng_hydr_dOase-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43756">
        <property type="entry name" value="CHOLINE MONOOXYGENASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43756:SF5">
        <property type="entry name" value="CHOLINE MONOOXYGENASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00848">
        <property type="entry name" value="Ring_hydroxyl_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00090">
        <property type="entry name" value="RNGDIOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="ISP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="14" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="13">
        <location>
            <begin position="52"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00014931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDM26274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="421" mass="47470" checksum="1B5767F1B6AFD221" modified="2014-04-16" version="1">MSTLKNYFGLGGTDAHSTPTDNNSPAHPLPSSWYSSQDIHELERRAIFCRKWLLITHKLRFPKTGDWLRYDIAGYAFILVKDREGNVNAFHNVCRHRAFPVVTEEGGTSPIFSCQYHGWSYGLNGKLAKAPGYQEVEGFDKSKNGLLPIHVHIDVNGFIWVNLDASEKPEISWEDDFKGVDLQPRFTGFNFEDYDFDNTGEMSGEYNWKIMAEHYNECYRFSTTQSDTSVSNLDSYAVDAKSTPEEIANGLKIASTYYFPNATMTVSPHFFFMQRLVPTGPTTCSVRYDVYRNKKFSAEEFEIISQVYKRIMSENQDRCVETQKNINMGKIQPAEEGPVNFQTVVRDLITQHHKREEDAGEQFWPARQRLPKGEAVSKEDIDFCSKLSKDGSPLTSGGCCGGGCGAGPPSRAATAPETMVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W6PXG5</accession>
    <name>W6PXG5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S01g002287</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PXG5"/>
    <dbReference type="OMA" id="GCMGRYL"/>
    <dbReference type="OrthoDB" id="1640476at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.225.20">
        <property type="entry name" value="Ub domain-containing protein, DC-UbP/UBTD2, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032752">
        <property type="entry name" value="DC-UbP/UBTD2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038169">
        <property type="entry name" value="DC-UbP/UBTD2_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039869">
        <property type="entry name" value="UBTD1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13609">
        <property type="entry name" value="UBIQUITIN DOMAIN CONTAINING 1 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16455">
        <property type="entry name" value="UBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DC-UbP/UBTD2 N-terminal" evidence="2">
        <location>
            <begin position="39"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM28476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="287" mass="32183" checksum="CEDA60D2D50EB3B2" modified="2014-04-16" version="1">MELLEYEAAAPTRDTSDRTTQPRQRTRHTASLPLNEHYNEPVRNHVWYSKRRTWTRAQLDRERTEFFETRVTGRPEIWAAVSTVISLIRNGDLATAQGILDAAGITVPTGDLCEGCYDEQGVLYRVPQCVVSDPENIVPSSSRTASEDGGPARYEEEQDVGMLSDSKLADDDDADASGDELISQDVERRREEKGKTSERDLIRVLARLSDRGGPDILLSIGKGQTVGFLARRVHQEAKLEDDRRVRIAYLGHLLNEREPLVDQGWKTGHVVNALISPVNDLNLGHRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W6PXN0</accession>
    <name>W6PXN0_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Adenylyl cyclase-associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PROQFM164_S01g002516</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">The N-terminal domain binds to adenylyl cyclase, thereby enabling adenylyl cyclase to be activated by upstream regulatory signals, such as Ras. The C-terminal domain is required for normal cellular morphology and growth control.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the CAP family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PXN0"/>
    <dbReference type="STRING" id="1365484.W6PXN0"/>
    <dbReference type="OMA" id="KSQQTHK"/>
    <dbReference type="OrthoDB" id="77251at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008179">
        <property type="term" value="F:adenylate cyclase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019933">
        <property type="term" value="P:cAMP-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.330:FF:000001">
        <property type="entry name" value="Adenylyl cyclase-associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.70:FF:000008">
        <property type="entry name" value="Adenylyl cyclase-associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.330">
        <property type="entry name" value="Adenylate cyclase-associated CAP, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001837">
        <property type="entry name" value="Adenylate_cyclase-assoc_CAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013912">
        <property type="entry name" value="Adenylate_cyclase-assoc_CAP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013992">
        <property type="entry name" value="Adenylate_cyclase-assoc_CAP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017901">
        <property type="entry name" value="C-CAP_CF_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016098">
        <property type="entry name" value="CAP/MinC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036223">
        <property type="entry name" value="CAP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018106">
        <property type="entry name" value="CAP_CS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053950">
        <property type="entry name" value="CAP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036222">
        <property type="entry name" value="CAP_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006599">
        <property type="entry name" value="CARP_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10652">
        <property type="entry name" value="ADENYLYL CYCLASE-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10652:SF0">
        <property type="entry name" value="ADENYLYL CYCLASE-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08603">
        <property type="entry name" value="CAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21938">
        <property type="entry name" value="CAP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01213">
        <property type="entry name" value="CAP_N-CM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00673">
        <property type="entry name" value="CARP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69340">
        <property type="entry name" value="C-terminal domain of adenylylcyclase associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101278">
        <property type="entry name" value="N-terminal domain of adenylylcyclase associated protein, CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51329">
        <property type="entry name" value="C_CAP_COFACTOR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01088">
        <property type="entry name" value="CAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C-CAP/cofactor C-like" evidence="6">
        <location>
            <begin position="367"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="28"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="254"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="320"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="32"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="261"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="279"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="320"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="357"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00054756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00072052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM28705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="526" mass="56496" checksum="C5ED83C05A016FD5" modified="2014-04-16" version="1">MASGGHMHNFTTLIKRLEAATSRLEDMAMSYDDSSAPKSLTGSPSSTPAIPQPPKPSPPPPAAPVAAPVPPQIEDFDALIKGDVQKFVNLGEKIGGLVAEQSKAVLRAFQAERTYLYVVTKAKKPDTQPPELMTDLHKASDSINNIRESNRASPLFNHLSAVAEGIVALAWFFESKPAEFVTDMIGGIEYYGNKVLKEYKDKDQVHVEYIKAYYQNFKALAEYLKKHYPKGLTWNNETGIDAMEALRQVKAGPAAVSGGALPPPPPPPPVPSLNFPGGGAPPPPPPPGIPPAPAPAAPAADMGAVFDQLNQGEGITSSLRKVDKSEMTHKNPNLRAGSIVPEGSSVRGKSPAPSKKPKPENMRARKPPRRELEGSKWLIENFDAPGEIIEVSAQQNQSILISRCNKTIIKVSNKANAIAIDNCVGLSLIVDSLVSSLDIIKCPKFAVQIDGTVPTLLMDQVDGATVYLSQESLNTEIFTSKCSAINITLPPPEGTDEDTKECPLPEQFKSYLKDGVLVSEIVEHAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W6PXN3</accession>
    <name>W6PXN3_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Oligopeptide transporter OPT superfamily</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PROQFM164_S01g002357</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PXN3"/>
    <dbReference type="STRING" id="1365484.W6PXN3"/>
    <dbReference type="OMA" id="TPTAYVW"/>
    <dbReference type="OrthoDB" id="627262at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045035">
        <property type="entry name" value="YSL-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31645">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER YGL114W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31645:SF0">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER YGL114W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="45"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="100"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="156"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="257"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="315"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="352"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="453"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="478"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="571"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="626"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="669"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="748"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="222"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="234"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM28546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="777" mass="83050" checksum="96B763CBB8AAE6F6" modified="2014-04-16" version="1">MDGNVPEQRQRTVGGPSLDQPPTDPIADPAQARATSPQSFTPRSLLVGLIIGALITFSNTYFGLQTGWISTMAMPSALIGFSVFKVLSKHLSFPFTPVENVLIQTVAGAVGTMPLGCGFVGVIPALEFLLKPGEDGPEGDGGEGEGGPLKLGFWKLVIWSLGVCLFGVVFAVPLRKAVIVREKLRFPSGTASALMLKVLHSSGSEEKVIAPESSRAGIFNTEAETAGPSQEDTGLLKDGDAEDQASKEQNWRSKMRILLGSFTVSGAYTLFSYFVPLVRAIPLFGVGMADNWLWTLNPSPAYIGQGIIMGPSTCMHMLFGAVLGWGVLSPLAKSRGWAPGPVNNWEDGSKAWIVWISLAIMLADSLVSLGWLVLRPILKYSPRWIAYFRSTRAGQWIALRLHSSQHSYINYSALEPEPHLLAHEDVAQHTLVTANEEDKDDAPPSELISTRTVVILLPLTLLLNVACMHFVFGDIISPFLSTLATLLAVLLSIMGVRALGETDLNPVSGISKLTQLLFSLATPASHFSRRTALVTNLLAGAVSESGALQAGDMMQDLKTGHLLGASPKAQFYGQIIGSLVGAVLSTAVYKLYVNVYEIPGEMFQTPTAYVWIFTARLVTGQGLPKMAGQVSVIAGIVWAFLTALRIVAASPAFARNGKPPPWRSWIPGGIAVAVGIFNEPSFTLARAIGGIIAWWWSRRHSESLNQQVDSGNATTMGSSLETELQDAQRSSISAEQASEKADAASSTVVVLASGLILGEGIMSIVNLLLASGRVPHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W6PY30</accession>
    <name>W6PY30_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cullin-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PROQFM164_S01g002477</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FM164</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11 12">Belongs to the cullin family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PY30"/>
    <dbReference type="STRING" id="1365484.W6PY30"/>
    <dbReference type="OMA" id="IREWDRY"/>
    <dbReference type="OrthoDB" id="27073at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902531">
        <property type="term" value="P:regulation of intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000014">
        <property type="entry name" value="Cullin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000007">
        <property type="entry name" value="Cullin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000011">
        <property type="entry name" value="Cullin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000026">
        <property type="entry name" value="Cullin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.130:FF:000003">
        <property type="entry name" value="Cullin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000029">
        <property type="entry name" value="Cullin homolog 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1310.10">
        <property type="entry name" value="Cullin Repeats"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.130">
        <property type="entry name" value="Cullin, Chain C, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045093">
        <property type="entry name" value="Cullin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059120">
        <property type="entry name" value="Cullin-like_AB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016158">
        <property type="entry name" value="Cullin_homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036317">
        <property type="entry name" value="Cullin_homology_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001373">
        <property type="entry name" value="Cullin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019559">
        <property type="entry name" value="Cullin_neddylation_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11932">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00888">
        <property type="entry name" value="Cullin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26557">
        <property type="entry name" value="Cullin_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10557">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00182">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00884">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75632">
        <property type="entry name" value="Cullin homology domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50069">
        <property type="entry name" value="CULLIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Cullin family profile" evidence="13">
        <location>
            <begin position="403"/>
            <end position="639"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00069612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDM28666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="764" mass="88247" checksum="460057697652F904" modified="2014-04-16" version="1">MSPAMPPVPHKDDLDSTWTFLEAGIESVMLNLDAGIDMKTYMALYTAVHNFCTSQKAVASGQGLQGSRGAHLLGEELYKLLGEYLSSHLNKVYKQSQSHTEEGLLGFYIREWYRYTTAAKYVNHIFRYLNRHWVKREIDEGKKNVYDVYTLHLVKWKTEFFEKVHEKVMDAVLNLIEKQRNGETIEQSQIKAIVDSFVSLGLDENDSSKSTLDVYRQYFQQPFIRATRSYYENESRQFVAENSVVEYMKKAEARLEEEKLRVGLYLHPDVTKSLTDTCLSVLVTAHSTLLRDEFQVLLDNERQDDLARMYRLLSRIKEGLDPLRATFENHVRRAGLAAVEKVASEGETLEPKLYVDALLQVHTRYQNLVDEAFNGEAEFVRSLDNACREFVNRNRVCKTSSSKSPELLAKYTDSLLKKGSKSAEESELEEMLVQIMTVFKYIEDKDVFQKFYSKNLAKRLVHVSSVSDDAETSMISKLKEACGFEYTNKLQRMFQDMQISKDLNNNYKVWQDKVLEDEDRKKMCDAHFQILGTGFWPLNAPTTPFLAPPEIVKTAERFQTFYFDKHNGRKLTWLWQLCKGEIKANYIKNAKVPYTFQVSTYQMGILLLFNETDTLSYGEIEKATTLATEILDPNLSILLKAKVLIASPEGAKPEPSTSFTLNYNFKSKKVKVNLNIQIKSEAKVEADDTHKTIEEDRKLLLQSAIVRIMKSRKKMKHVQLVQEVIQQVKSRFPPKIPDIKKNIEALMEKDYIERMDGDEISYIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W6PYY0</accession>
    <name>W6PYY0_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PROQFM164_S01g003037</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PYY0"/>
    <dbReference type="OMA" id="HPVAYFM"/>
    <dbReference type="OrthoDB" id="10262656at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17330">
        <property type="entry name" value="MFS_SLC46_TetA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001958">
        <property type="entry name" value="Tet-R_TetA/multi-R_MdtG-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504:SF2">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04150)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01035">
        <property type="entry name" value="TCRTETA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="91"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="191"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="292"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="350"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="379"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="406"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="442"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="480"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="20"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM29225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="542" mass="58428" checksum="BBF7BC8DA0FA4F34" modified="2014-04-16" version="1">MALTPQSRLHPSPDSFPTAQLFLLAICRVAEPIALTSIFPYSWVMVKDFHMANGNNASFYAGILISAFSLAEALTGMLWGALSDRVGRKPIIISGSFGTMASLLLVGMAPNFWIALAGRALGGALNGNIGVIQTMVSELVKRPEHEPRAYAIMPFVWSIGTIIGPAIGGLLAKPTEGFPSLFPADGLFGKFPYLLPNLVCCVLLLLSIIGSWLFLQETHPDMQPGKANRHLDQAAEQPLLVTSGATANAGVDLRAESYGTFNQVHLHNDESWNVQADGSSPATKKLPKPKACTWRVIMLVVALAIFTYHSMTYDHLLPIFLQDKDPRGPSPSHHSPFDIPGGVGLSTRTVGVIMSTDGIIALVIQSIIFPLLAHYLGIWRLFVIVTVLHPIAYFMVPFLVFLPRQLIYVGIYACLIVRNILSIIDYPLLLILIKQASPSDSVMGKINGLAASAGAASRTFAPPISGLLYSAGAEIGCTALAWWGSSLVALFGALQLWFIQRDKRSSATVEPAAVCHYVALPEQPHDDIVHIIVNEGGAHTEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W6PZ08</accession>
    <name>W6PZ08_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S01g003052</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PZ08"/>
    <dbReference type="OMA" id="YTSTERV"/>
    <dbReference type="OrthoDB" id="5424209at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM29240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="141" mass="15564" checksum="E913CE355CCF81F5" modified="2014-04-16" version="1">MSSPEVGFRYSNNNSSDMIDRPYHSGLILDTHDGLGLSKSGRSTGLTSSVLYSLESVELDRLKSKQGHGYHFVINWLGMSRVRNPQHFAEAGDYGAWIARVDGMVFGMLTGGNQRQGTTYFCQMTAPLSSFESFRRGLMGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W6PZ30</accession>
    <name>W6PZ30_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Terpenoid synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S01g003072</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PZ30"/>
    <dbReference type="STRING" id="1365484.W6PZ30"/>
    <dbReference type="OMA" id="IYCPRYH"/>
    <dbReference type="OrthoDB" id="3004402at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19086">
        <property type="entry name" value="Terpene_syn_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM29260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="387" mass="44540" checksum="BD59059D185FBDF3" modified="2014-04-16" version="1">MCAASVVEIDNCQPKSPASRMQLIEVAMHRIQRICIWKKLTNERRRKVALAVNRPILSSYLYSTNNSNSARQYSTAQNAPCAIPASQLESKTHPLGWELIQAQVEPYFGDNWNFPSEKEKKGFLGLGLSRAFSHFFPLTLYDRIDVTCKMLYLSLLIDDQLEKMSFTQMLSYRDRLMKVALGAASPDRCICLEWMLHDTVMAMRSMDEVLANDVAQGFCQLLQAQTSQERTTANTLGSYLKFRETDVGKTLYTALIRFGAKLDLTPTALENTAALESTAFRHVSVMNDIYSWEREWKVYQENPTDGAQPFSAIYILANETGLPYTACRRLMYSYCRELELVFKQSSVEIRHNTMEGLTHELEMYIKGLEYFMCGIELWSQWTPRYRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W6PZ68</accession>
    <name>W6PZ68_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MARVEL-like domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PROQFM164_S01g003117</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PZ68"/>
    <dbReference type="OMA" id="NCGSIWH"/>
    <dbReference type="OrthoDB" id="4074965at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008253">
        <property type="entry name" value="Marvel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39608">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G08640)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39608:SF1">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G08640)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01284">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="MARVEL" evidence="6">
        <location>
            <begin position="8"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM29305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="166" mass="18686" checksum="81978750BC87D6CE" modified="2014-04-16" version="1">MPVISRLASIILRVAEIAFAAVVAGVIGHYLAQVNHSGTDIDWWPQSRWIYTEVIAGLSILLGLIWLIPFASGFFSWPLDILISFAWFAAFGVLVDTIRRLPCGSIWSWHFRGDQTCGRWKAAEAFSFLSAIVWLASGIVGIWFTFRVRQSTSDGVRRRRWGRSAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W6PZT4</accession>
    <name>W6PZT4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Origin recognition complex, subunit 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PROQFM164_S01g003048</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ORC3 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PZT4"/>
    <dbReference type="STRING" id="1365484.W6PZT4"/>
    <dbReference type="OMA" id="YCLMEHY"/>
    <dbReference type="OrthoDB" id="10265211at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005664">
        <property type="term" value="C:nuclear origin of replication recognition complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20704">
        <property type="entry name" value="Orc3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020795">
        <property type="entry name" value="ORC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045667">
        <property type="entry name" value="ORC3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040855">
        <property type="entry name" value="ORC_WH_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12748">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12748:SF0">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07034">
        <property type="entry name" value="ORC3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18137">
        <property type="entry name" value="WHD_ORC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Origin recognition complex subunit 3 N-terminal" evidence="7">
        <location>
            <begin position="46"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="Origin recognition complex subunit 3 winged helix C-terminal" evidence="8">
        <location>
            <begin position="590"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM29236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="697" mass="77847" checksum="39748DEEF5736183" modified="2014-04-16" version="1">MDADGLNDALGLSNDKPQNLGSYIYQPPKHGKSAGERPSKRRKVSSTTGRDDQADQQRFVPLLNGDENAESVQLRYDTYQELWSKQENKIQNILEDVDSAVLADVLSFVRNTSPQTCDGCIPTALVTVGSNVSSLSRLLSRLNGQLISTEEGSVVVLESGDAPNLKTTLKNIIRAAVTNTDGNDGYQKFLTDRAGPRLLGYDLDLLHDYVQRKGTKKLVLALRDSEAFDPGLLTDLLSLFKSWLDRIPFTVLLGISTSVELFEGRLPRSCVALLQGKHFEVQEAGNCVDRIYETLQTDSGTNLWLGRNVTNTLFENTSDYFQSPEAFSRMVKYAYMSHFFANPLSVLLANPDSTVLAQNKLCEAVRNLPSFRMFCEDLVEEGSIKQIRDLLEDDEYLIQETPKYLDANQQRMRGMFQAVRVIYVCLEHTQSAKKTTVPDLSVRALSGELSESTIVEEMVAAAKTLDSDKLDELLVRLRGILISREADAIQEDLKTLLETCPESGPLRSGYNINSTVTRTTVVQQRIRLSKGQADLSEQAVEYTNIVDRLVALLQVYLTETLINPQDLFLHEAFLFDLRNPLKETFAPRPRFAIERALATPFDYLLSSSDATMTKVSAKQPATAILYQLYLDSGALVNVHDLWQAFYGVFETEEADGCDDRVVMSLFYGALSELKAFGVIKNSRKKTDHLAKSAWMGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q087</accession>
    <name>W6Q087_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mitochondrial import protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S01g003173</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q087"/>
    <dbReference type="STRING" id="1365484.W6Q087"/>
    <dbReference type="OMA" id="KPPTFWG"/>
    <dbReference type="OrthoDB" id="5529571at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070096">
        <property type="term" value="P:mitochondrial outer membrane translocase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045040">
        <property type="term" value="P:protein insertion into mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013262">
        <property type="entry name" value="OMP_MIM1/TOM13_mt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28241">
        <property type="entry name" value="MITOCHONDRIAL IMPORT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28241:SF1">
        <property type="entry name" value="MITOCHONDRIAL IMPORT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08219">
        <property type="entry name" value="TOM13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="53"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM29361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="130" mass="14205" checksum="71CC21E0A79AB30F" modified="2014-04-16" version="1">MASDPTSASPAELYDSAITVPSDSENYSANHELSSSVPSTTSSLMMLYKPPSVWGLLRGAVINLFLPFVNGLMLGFGELFAHEAAFRLGWSNTKIFPNHRRSHAVGPGVEMRELPSERRRPGLRDTASLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q0M2</accession>
    <name>W6Q0M2_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Glycoside hydrolase, catalytic domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PROQFM164_S01g003633</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q0M2"/>
    <dbReference type="STRING" id="1365484.W6Q0M2"/>
    <dbReference type="OMA" id="GMCPMLW"/>
    <dbReference type="OrthoDB" id="412536at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050386">
        <property type="entry name" value="Glycosyl_hydrolase_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297:SF41">
        <property type="entry name" value="ENDOGLUCANASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G01830)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297">
        <property type="entry name" value="GLUCAN ENDO-1,6-BETA-GLUCOSIDASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="4 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 7 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004879514" evidence="8">
        <location>
            <begin position="18"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="9">
        <location>
            <begin position="55"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDM29820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="228" mass="24820" checksum="D8633D0C2511725C" modified="2014-04-16" version="1">MQILLSSALALVGMAQATTVCSGTFSTISAAEFVSNLHPGWNLGNNLDAVPDEGSWNNMPVVASTVDTIKDAGFRSVRLPVTWAYHFTGGSPNWTVDPAWLQRVSDVVDMIVARGIYAIVDVHHDSWVWADATQSGTNLTMIEEKFYIAFEPINEPPCNTAVDVTESNKLNNIFLQAINDAGGFNSQRIVNLVGGGEDSVKTADWFVAPSGFWNPYAIQFHYYSPCGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q0U4</accession>
    <name>W6Q0U4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Zn(2)-C6 fungal-type DNA-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PROQFM164_S02g000322</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q0U4"/>
    <dbReference type="STRING" id="1365484.W6Q0U4"/>
    <dbReference type="OMA" id="EWHDELR"/>
    <dbReference type="OrthoDB" id="2962993at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051711">
        <property type="entry name" value="Stress_Response_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47540">
        <property type="entry name" value="THIAMINE REPRESSIBLE GENES REGULATORY PROTEIN THI5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47540:SF6">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="23"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="589"/>
            <end position="610"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM30173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="692" mass="76653" checksum="50E6B81C68CD1D05" modified="2014-04-16" version="1">MDRAESSGESQRRAKRTKRSSVACRRCHAQKVKCSGGTPCSACLTAGQASACNYPFRERKVTISESYLKQLEAASNVLRHQNESARSQPRSPIDVDQLLDSTITSAVSDLGVVNPLFDARREKPPTQIVTEPSFVGEAACDAFIERLLQSLSQREANSLPPPHKYMIDLPGARMPAINYTLPDRVHAKLLIQVAARFIGNGQHLYLNSYMEEVDSVYKKDAEPSSIWLCKLLALVALGELYSNRRRSNGDNRAPGEEYFVSALSMLHDQYEDTTTLHVEVYLLLACYSNALGRVRSAYTYSGIGMRIALSLGMHRSSSSLHTSAVERESRRRIWWSLYLFDRLTCSKLGQPTAVNDDDIDVELPTMDGLTPEEKEEFPDPRHLFASVGLAKIAGDILSDIYCMPGRKKIHFVKRVHGILSNLRDWDDTLPQHLAFRWDDSNRHVASLHLCYNQCIIHTTRPILLHLFRVQFCLDGSRTADQPSQSFSPTTTALADSCVNAARTSNRILSKLFVDGTLATLGYWDAHYLFSSTLILLMSAVMSPSQAVSDAVDTALSVLCSMRDDGNVPANDYYERLLLVQKSIAELRDGVRKGRDGGPPTAAQSPQIAGTGHERAQLDEVGWAAQNNDVGGVGIENFRLEDNLDALANPYIDGFLAEKSFTWPSNAFPDGTTLQQFANELGVSFGLLDPHCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q0X7</accession>
    <name>W6Q0X7_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g001665</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q0X7"/>
    <dbReference type="STRING" id="1365484.W6Q0X7"/>
    <dbReference type="OMA" id="MMFPPVL"/>
    <dbReference type="OrthoDB" id="4868994at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM27854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="132" mass="14476" checksum="B338A630FE990EDA" modified="2014-04-16" version="1">MADDSTVEETKETLIQRFRAWGENSFPPTLLASMIAAQHMRPFQFFPMLFPPVLIFSSYANLQGFKTDTAGISGAVSGLYLLLAARRRQPFMKKLGVRGVVRGATMGLALVNMIGGGLAYTLGRKEEEEDAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q258</accession>
    <name>W6Q258_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="4">60S ribosomal protein L35</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">RPL35</name>
        <name evidence="4" type="ORF">PROQFM164_S02g000539</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL29 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q258"/>
    <dbReference type="STRING" id="1365484.W6Q258"/>
    <dbReference type="OMA" id="VMNQKAR"/>
    <dbReference type="OrthoDB" id="528635at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030684">
        <property type="term" value="C:preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00427">
        <property type="entry name" value="Ribosomal_L29_HIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.310:FF:000002">
        <property type="entry name" value="60S ribosomal protein L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.250.3450:FF:000001">
        <property type="entry name" value="60S ribosomal protein L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00374">
        <property type="entry name" value="Ribosomal_uL29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001854">
        <property type="entry name" value="Ribosomal_uL29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018254">
        <property type="entry name" value="Ribosomal_uL29_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045059">
        <property type="entry name" value="Ribosomal_uL29_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036049">
        <property type="entry name" value="Ribosomal_uL29_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00012">
        <property type="entry name" value="L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45722">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45722:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL29-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00831">
        <property type="entry name" value="Ribosomal_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46561">
        <property type="entry name" value="Ribosomal protein L29 (L29p)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00579">
        <property type="entry name" value="RIBOSOMAL_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM30390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="124" mass="14550" checksum="451576F03C685371" modified="2014-04-16" version="1">MSSKVKAGQLWGKNKDELATQLEELKLELNQLRVQKISSGASSKTQRIGEVRKSIARVLTVINANQRAQLRLFYKNKKYLPLDLRPKLTREIRRRLTKHERTQTTDKLRKRAIHFPQRKYAVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q2N1</accession>
    <name>W6Q2N1_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ARID/BRIGHT DNA-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PROQFM164_S02g000730</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q2N1"/>
    <dbReference type="STRING" id="1365484.W6Q2N1"/>
    <dbReference type="OMA" id="NPIVCGR"/>
    <dbReference type="OrthoDB" id="1938591at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016514">
        <property type="term" value="C:SWI/SNF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16871">
        <property type="entry name" value="ARID_Swi1p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.60">
        <property type="entry name" value="ARID DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051232">
        <property type="entry name" value="ARID/SWI1_ChromRemod"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001606">
        <property type="entry name" value="ARID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036431">
        <property type="entry name" value="ARID_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13964:SF27">
        <property type="entry name" value="HAT-TRICK, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13964">
        <property type="entry name" value="RBP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01388">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01014">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00501">
        <property type="entry name" value="BRIGHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46774">
        <property type="entry name" value="ARID-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51011">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="ARID" evidence="5">
        <location>
            <begin position="277"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="50"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="419"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="103"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="119"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="152"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="165"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="429"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="449"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="474"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="515"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDM30580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="1000" mass="109761" checksum="FA11AD4573768825" modified="2014-04-16" version="1">MNAWLDASNIPGQDNGAFHPSTIDPSTAFLHGSPTPQDPSQFRMFNNGVPRNASPGFHNPNQVIPSKRARPEDGMPMSPRPVPGGLTGSRSQTPHQPFPGYQGPTNGNPQFPQHPTPYQHLQQGASPNVTHSPIMQDFDQQSARLGTASPSPFSPAGPHPGPHMSPSQSDHGSRVNTPQNANFMQAQQFGMTSGPPQPSMLAPQFNGMQQVPQGYHQALANQQQRLHAMQQQSRMNPNATMAGRQVQGGMNPMGNPQQSMGGMRQMPPNMQSNVPKPSNPEGFLRSLQKFMMSQNLSVDTNPIVSGRPINLVQLYATVMKMGGSKKVTATNMWPAVAHQLQFPQMQFPMAAQEIQAHHSRNLAPYEQAFISSQQKQMADHMQQQQQQMQQQQLQQQQQLQQQQQQQQQQQQQQQQQQQQLQHQGGIQRPPSQFQSPSVKPNPGFEQAQAIAQSPQNHTPIHNNAPVNGFATPTHARSQSRPAQAGHRSSISRASQPAVPLTEATGQFAAPSPQSVKGVTPVPGQQQPGQQEQKSEQLVKRPIEETFKPMVLKGNRFHGPIAVDEMYQIGEDISRLKPDVPGFAELGIVDIHALTMALKSGIYAEIRVALDTLTTLSGEPSVQISLENCDDLVESLIDCAEDQADLLAEHTLEESDTMTLRSYDQVTRDCQSENTSLLDVPEFGSIEYELDRAVDRLICITTILRNFSFSETNFLSLGIPPVAQLFSSVFRYMGTRKMFLRTSHNTLDFMKDAVILLSNLAHVVQIPGKDEALNLLIFLLAFSPEPEPISPAGKVMFTAFNSSVDRYTPAAVDGLAKMLARDDPNRTFFKAIFSGDGSAPPQPELLTRAFGLAISCVPDKKPMAVVDARKVFLMQGLLSADVLTTFADGSLAKAWLESVDGFAVHLLRLSCALCTERIPQINMRQRSQAEADAYAFSSIVNRGLGILRRLAEKSKQVDNTSPLNIPSGILPRKESLLGALLLPNIDGGVVRQLLTYARLAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q2Q6</accession>
    <name>W6Q2Q6_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phox homologous domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S02g000400</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0507 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1365484.W6Q2Q6"/>
    <dbReference type="OMA" id="HFPMIAR"/>
    <dbReference type="OrthoDB" id="7464126at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030133">
        <property type="term" value="C:transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097422">
        <property type="term" value="C:tubular endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045022">
        <property type="term" value="P:early endosome to late endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06093">
        <property type="entry name" value="PX_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000443">
        <property type="entry name" value="Putative vps9 domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.80:FF:000009">
        <property type="entry name" value="VPS9 domain protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1520.10:FF:000058">
        <property type="entry name" value="VPS9 domain protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.80">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051248">
        <property type="entry name" value="UPF0507/Ank_repeat_27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003123">
        <property type="entry name" value="VPS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037191">
        <property type="entry name" value="VPS9_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24170">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24170:SF1">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G09870)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13857">
        <property type="entry name" value="Ank_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02204">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109993">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51205">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VPS9" evidence="3">
        <location>
            <begin position="346"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="162"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="221"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="523"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM30251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="1307" mass="146332" checksum="E3F33C1D80E17D61" modified="2014-04-16" version="1">MHPLNPFLRAFFRSTVPGQCVPVENHVLLVPTTESLIGSRDRESNLLYSDLCASEEFLGSHVLRIPIHTVSANSKEESNMRENRGKAKQVTTFNGRTVIIKDNSVYSNKGFKSLTQAQLLSDVLYYNPSNESRPWLIYYISRPLIGTYDPAKIIPAVVPGSGASVVGQTTPDRRYGNGDSIGTPPKQEIKSFGELLANYPMIARQMHPGLERLFKEFGKELGKPLPPPPSRSPSASGSERVHKLSRVESFTDESSSIRSWSSRSRGRLPFNSEEYFEDDEDLMRRSLETAVTAAIDLFRLVDKQQLSLLGATTDLTGPLVERLIERYVAEQVHEPLLFPRLCSFRQPEDTELDSRIRQMESIDVSQVGISVEGGREGKRELIRRLGRAVEEFRKINDARCPHDMLNTLLGTVKVISFPGSYDQLDGSPSEKGTSSVTINADVLVSLLLIVVIRSQTRHLQARLLYMQHFIYIDDVDNGEMGYALSTFEAVLMYLVTDSAGLRRASARNRRLWQATKAGRISDMKSILEPNEDHGAIDDTSPPEPGRKSVLFQTDEADEPDDLPLDHSYTSHTNGDSYLDEAVVEAPPLSHVFPFQTWDDLSIIQESHPHRPVKKVSMDVRSLSESSAVSFISRTATLGSMASGIEGDNSIETLTKTQDPAGHSIPMMAVEARQTEALKYLLTLEEYYPLEEIIQDTNTDGTTLLNAAVQLAHTEIVKILLDFLFAKTDISVVASYLTKSDVHGRTVAHYLFSTPSLLERLGSIIPWRQRDKHGQTPLFALCRSYDHPEYKSMVQAALTAAQWAQGDNKPLQLDDHVDMKGNTLLHIVGDPDITRRILQDSDCDPNATNDKRFTPLMMASKYGRVDQVRILFLDPRVDVHIKEARGLTAVELAKDDEVRNRIDDLILLSHPPSACGDPSGRVTTVVRSYFVEDATVRFILKSGAPFPPTESVASSRPGSTTYTVTTCRRNFSDFENLAKWLAVEHPASYMPSLSDFRNPFQIHSKPSRSVLHDLQERLDRFLKTLLAHPTFSTHEMLWEFFLVPELQPEMVADRSYRKAAVLTETIADEYAPVSLEGMRDTEQFITHAQDIVRGVHVNTRSLIRRGHALHNATSDLADAVMICSSVLSTLRAPTNALPISHIEAFARYATYLSTSRSDSSPLLQYLAALSSVDNTTAAILISLSRPLALMSSLSSTNRHTSRSRSSLLSSSLPRKFNINLPGFEESRQKSVRDLEQKVREGESESTRLAKEISWNKDVVVGELAGWTSWRERVGRDAIRSFVKDTLVREKERGKRLERCLRSVRDTNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q2S2</accession>
    <name>W6Q2S2_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S02g000420</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q2S2"/>
    <dbReference type="OMA" id="RICCALQ"/>
    <dbReference type="OrthoDB" id="4279496at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM30271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="116" mass="13015" checksum="2FE4217C18EEC3CB" modified="2014-04-16" version="1">MDIPAPDSIYCKDRSYFLDLLHAQIMQLRSKPGLRFQVAEKLRELSLMTPGCIEASDIVGDTLFHRTCCALQPIFYTAIATLLGNISPVCVLRVADELEAAVPLEIQNPWSHPDTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q3Q4</accession>
    <name>W6Q3Q4_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S02g000756</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q3Q4"/>
    <dbReference type="STRING" id="1365484.W6Q3Q4"/>
    <dbReference type="OMA" id="FYLPRHW"/>
    <dbReference type="OrthoDB" id="1668230at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF260">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="75"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM30606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="323" mass="35791" checksum="AF56CC60E6502257" modified="2014-04-16" version="1">MLMITWCDWFHCKGAPCYPCSPTKNVRLEMSSLPRPISWPPVGDVRTEDNQPNPLSSVDGYSDNIAPNVGYSSVRDVQGQLISGGITGIVELLDDGTALKAPYPGSEIENNIIDIAKEASIYRRIGPHKRLVRMLGHSREGLVLEYMKNGDLKTYGSRLEAVDLLHRNGTIDCNIKPRNLLLDTAFDIKIIDFSGSSLDGSKPASGEGTRFFLPRHWREQPTVATDLFALGSTLYEITQGTSPYEELPSNEVERFFTQKEFPDISGIVCGQIIKQCWLSQIDSAADVKTAVWDIISRTSKVDCIPHLDGLDTAQDMLIGLVYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2024-10-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q3V0</accession>
    <name>W6Q3V0_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S02g000801</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q3V0"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM30651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="57" mass="5917" checksum="6589454D168AFAE7" modified="2014-04-16" version="1">MDAQDLQLIFSGDRYVLHPCIAASTSALGKDQHTTPPCESDNGGVVMAPSRTPSAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q3Z8</accession>
    <name>W6Q3Z8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S02g001220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q3Z8"/>
    <dbReference type="OMA" id="FLMKEYY"/>
    <dbReference type="OrthoDB" id="5229017at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="508"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="513"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM31070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="762" mass="84810" checksum="D73FDE1759C5DB7F" modified="2014-04-16" version="1">MSQYPPTRPWAALSAIDRDHESGLFYEDDVPHTAKMTVNMSQPDFEDRGPSMAENLRVIAERSAARRNGTAMNKNDMFSKPLPPIPQQEAPQSAATVGQEGVVQGSGDNIDKMSIHYVLDRSNMHGRHDQSSFAQREASQIATQVGQKAVANGCVHSSEKIKLNLLLDGCKLEGYDDETPSIQPSGSEPTLPPLSYHSYNTQATYANSSSAYGCLAREYDALYDAPASETPGSQVNPSPYRNGDSPTSWYESSPTCYEFSPGPQIALVPNTTPVHEIKEENQFADLGATIDELLALINPEKEYSRLANDNHSPESSSSAYHFTTPSSVSTDIYHADQYSSLAYQAPDFVIRDAESPASPDTIRGVTPASPAWSPPSPCPKGCCYWSSDDEATASPEPQFDREWSASDVSLQESPMLPSLPHVASYPSSERRASYLKWREERAHMISAEEALVPRQLNVMKKATFTMDVPIHNVSQHQAAVHTSDSTDEGPSRAASFVSNYSDVSNTISSATLSPVPRSPDVSSSEGSVDSRGIKRKRFTKTLFGKKGYLDDYEGRRDTRFRFFKEAIERGHSTFGNIKGMFWDENRGLISPSTKPSIVTENTAPITLNTEVQSILYAEIEGMITHAANEFLMKEYYDGHLSTSSLQKVKRRWEKKHMPGVPEFRFDQGTQYRIISANREHLNFGRPSNGLGRNTVLGNWKRIWKNMSIRTFVSPDSVIKKNIHDIMDLLELLNAREGHLELLMALDAHVRGQLQKHEMLLYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q451</accession>
    <name>W6Q451_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S02g001533</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q451"/>
    <dbReference type="STRING" id="1365484.W6Q451"/>
    <dbReference type="OMA" id="GCMPVMF"/>
    <dbReference type="OrthoDB" id="5361958at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM31383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="475" mass="52764" checksum="F219E2620485216F" modified="2014-04-16" version="1">MAVYTRSSPLVQQIQQSSPWVDIYTDSATSPLRVRSVTHNISSVSHAHPEPRRWQNPGGWGPRHMNDTAPFTLWDDTGRKYRLPTKEEFQWISKKFGDGKISLSGWFICIATDNPPKPVPLTLGCMPVMFVGVNQSFLEPLPKAPYPNPRLPDPCPDLRWPAMEFPTDADNITFLEALEPLAHVRAVMYLPSWIIIELEYGDSRVYELKSLPGIVAGRTALYHHAVAPFHKKMKNLTRGQQLDPAESQTSLRPLPQDTHNYLQYSFLSPGHRIESGYSLSDSGYESTTRASSAGVKLRNSRGEEALSIAYHGFPISSEVYHLDTHQEIIGDVINIRPELDVALVKPTSTASTKFKNTCYFQAQPPKTLLEGKDIRAGSWAEVDGMSSGLLNLLSYGMMKEKPVSGSPKIPFAQWRSFNLQTSWGVVNEVIAKGICGAPIVSCDTSGVTGFFHLFDGMNCLSATLDDLVAEGWQIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q4D8</accession>
    <name>W6Q4D8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Probable transposable element</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S01g002845</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q4D8"/>
    <dbReference type="STRING" id="1365484.W6Q4D8"/>
    <dbReference type="OrthoDB" id="4367135at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM29034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="147" mass="16943" checksum="B43FA1AC25F5DED0" modified="2014-04-16" version="1">MRIASAGLAHTGASQRRSADVFDAVSSIINATRSPQFTASLASQRNTKSQKAKELREKVDSFTERWTAFQDRYADPIFQSILGYIQYEWLYECPEKFLHIHTSQYLHLNKIATSRNESTHWLLKQDLIVSTNDLPMRGRSSNQEDLY</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2020-10-07" modified="2025-06-18" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q4Q9</accession>
    <name>PRX2_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Aristolochene synthase</fullName>
            <shortName evidence="9">AS</shortName>
            <ecNumber evidence="3 8">4.2.3.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">PR-toxin biosynthesis cluster protein 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Sesquiterpene cyclase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">prx2</name>
        <name evidence="9" type="synonym">ari1</name>
        <name evidence="11" type="synonym">ORF2</name>
        <name type="ORF">PROQFM164_S02g001465</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>FM164</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1993" name="J. Biol. Chem." volume="268" first="4543" last="4548">
            <title>Aristolochene synthase. Isolation, characterization, and bacterial expression of a sesquiterpenoid biosynthetic gene (Ari1) from Penicillium roqueforti.</title>
            <authorList>
                <person name="Proctor R.H."/>
                <person name="Hohn T.M."/>
            </authorList>
            <dbReference type="PubMed" id="8440737"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="1980" name="Appl. Environ. Microbiol." volume="39" first="770" last="776">
            <title>Production of eremofortins A, B, and C relative to formation of PR toxin by Penicillium roqueforti.</title>
            <authorList>
                <person name="Moreau S."/>
                <person name="Lablache-Combier A."/>
                <person name="Biguet J."/>
            </authorList>
            <dbReference type="PubMed" id="16345540"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2004" name="J. Am. Chem. Soc." volume="126" first="7212" last="7221">
            <title>Aristolochene synthase: mechanistic analysis of active site residues by site-directed mutagenesis.</title>
            <authorList>
                <person name="Felicetti B."/>
                <person name="Cane D.E."/>
            </authorList>
            <dbReference type="PubMed" id="15186158"/>
            <dbReference type="DOI" id="10.1021/ja0499593"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>BIOPHYSICOCHEMICAL PROPERTIES</scope>
        <scope>MUTAGENESIS OF TYR-92; ASP-115; ASN-244; SER-248 AND GLU-252</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2014" name="Fungal Genet. Biol." volume="62" first="11" last="24">
            <title>Molecular characterization of the PR-toxin gene cluster in Penicillium roqueforti and Penicillium chrysogenum: cross talk of secondary metabolite pathways.</title>
            <authorList>
                <person name="Hidalgo P.I."/>
                <person name="Ullan R.V."/>
                <person name="Albillos S.M."/>
                <person name="Montero O."/>
                <person name="Fernandez-Bodega M.A."/>
                <person name="Garcia-Estrada C."/>
                <person name="Fernandez-Aguado M."/>
                <person name="Martin J.F."/>
            </authorList>
            <dbReference type="PubMed" id="24239699"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2013.10.009"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>PATHWAY</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2015" name="Angew. Chem. Int. Ed." volume="54" first="12167" last="12170">
            <title>Identification of intermediates in the biosynthesis of PR toxin by Penicillium roqueforti.</title>
            <authorList>
                <person name="Riclea R."/>
                <person name="Dickschat J.S."/>
            </authorList>
            <dbReference type="PubMed" id="26274339"/>
            <dbReference type="DOI" id="10.1002/anie.201506128"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="7">
        <citation type="journal article" date="2017" name="Appl. Microbiol. Biotechnol." volume="101" first="2043" last="2056">
            <title>Penicillium roqueforti PR toxin gene cluster characterization.</title>
            <authorList>
                <person name="Hidalgo P.I."/>
                <person name="Poirier E."/>
                <person name="Ullan R.V."/>
                <person name="Piqueras J."/>
                <person name="Meslet-Cladiere L."/>
                <person name="Coton E."/>
                <person name="Coton M."/>
            </authorList>
            <dbReference type="PubMed" id="27921136"/>
            <dbReference type="DOI" id="10.1007/s00253-016-7995-5"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>PATHWAY</scope>
    </reference>
    <comment type="function">
        <text evidence="3 4 5 6 7 8">Aristolochene synthase; part of the gene cluster that mediates the biosynthesis of PR-toxin, a bicyclic sesquiterpene belonging to the eremophilane class and acting as a mycotoxin (PubMed:24239699, PubMed:27921136). The first step of the pathway is catalyzed by the aristolochene synthase which performs the cyclization of trans,trans-farnesyl diphosphate (FPP) to the bicyclic sesquiterpene aristolochene (PubMed:15186158, PubMed:24239699, PubMed:8440737). Following the formation of aristolochene, the non-oxygenated aristolochene is converted to the trioxygenated intermediate eremofortin B, via 7-epi-neopetasone (PubMed:24239699, PubMed:26274339). This conversion appears to involve three enzymes, a hydroxysterol oxidase-like enzyme, the quinone-oxidase prx3 that forms the quinone-type-structure in the bicyclic nucleus of aristolochene with the C8-oxo group and the C-3 hydroxyl group, and the P450 monooxygenase ORF6 that introduces the epoxide at the double bond between carbons 1 and 2 (PubMed:24239699, PubMed:27921136). No monoxy or dioxy-intermediates have been reported to be released to the broth, so these three early oxidative reactions may be coupled together (PubMed:24239699). Eremofortin B is further oxidized by another P450 monooxygenase, that introduces a second epoxide between carbons 7 and 11 prior to acetylation to eremofortin A by the acetyltransferase ORF8 (PubMed:16345540, PubMed:24239699, PubMed:27921136). The second epoxidation may be performed by a second P450 monooxygenase (PubMed:24239699). After the acetylation step, eremofortin A is converted to eremofortin C and then to PR-toxin (PubMed:24239699). First the conversion of eremofortin A to eremofortin C proceeds by oxidation of the side chain of the molecule at C-12 and is catalyzed by the short-chain oxidoreductase prx1 (PubMed:16345540, PubMed:24239699). The cytochrome P450 monooxygenase ORF5 also plays a role in this step (PubMed:27921136). The primary alcohol formed at C-12 is finally oxidized by the short-chain alcohol dehydrogenase prx4 that forms PR-toxin (PubMed:16345540, PubMed:24239699).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 8">
            <text>(2E,6E)-farnesyl diphosphate = (+)-aristolochene + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19825"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43445"/>
            <dbReference type="ChEBI" id="CHEBI:175763"/>
            <dbReference type="EC" id="4.2.3.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="2">Binds 3 Mg(2+) ions per subunit.</text>
    </comment>
    <comment type="biophysicochemical properties">
        <kinetics>
            <KM evidence="3">0.6 uM for (2E,6E)-farnesyl diphosphate</KM>
        </kinetics>
    </comment>
    <comment type="pathway">
        <text evidence="3 8">Sesquiterpene biosynthesis; aristolochene biosynthesis; aristolochene from farnesyl diphosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="5">Reduces the production of PR-toxin and leads to a large increase in mycophenolic acid production.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the terpene synthase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.9" evidence="3 8"/>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q4Q9"/>
    <dbReference type="SMR" id="W6Q4Q9"/>
    <dbReference type="STRING" id="1365484.W6Q4Q9"/>
    <dbReference type="OMA" id="FQMSGNE"/>
    <dbReference type="OrthoDB" id="3004402at2759"/>
    <dbReference type="UniPathway" id="UPA00177">
        <property type="reaction ID" value="UER00582"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045483">
        <property type="term" value="F:aristolochene synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00687">
        <property type="entry name" value="Terpene_cyclase_nonplant_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034686">
        <property type="entry name" value="Terpene_cyclase-like_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35201:SF4">
        <property type="entry name" value="BETA-PINACENE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35201">
        <property type="entry name" value="TERPENE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19086">
        <property type="entry name" value="Terpene_syn_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000451228" description="Aristolochene synthase">
        <location>
            <begin position="1"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="340"/>
        </location>
        <ligand>
            <name>(2E,6E)-farnesyl diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:175763"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="341"/>
        </location>
        <ligand>
            <name>(2E,6E)-farnesyl diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:175763"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="1">
        <location>
            <position position="92"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="1">
        <location>
            <position position="112"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="1">
        <location>
            <position position="178"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="1">
        <location>
            <position position="334"/>
        </location>
    </feature>
    <feature type="mutagenesis site" description="Causes 100-fold reduction in kcat but a 50-fold decrease in KM, resulting in a 2-fold decrease in catalytic efficiency." evidence="3">
        <original>Y</original>
        <variation>F</variation>
        <location>
            <position position="92"/>
        </location>
    </feature>
    <feature type="mutagenesis site" description="Abolishes catalytic activity." evidence="3">
        <original>D</original>
        <variation>N</variation>
        <location>
            <position position="115"/>
        </location>
    </feature>
    <feature type="mutagenesis site" description="Abolishes catalytic activity." evidence="3">
        <original>N</original>
        <variation>L</variation>
        <location>
            <position position="244"/>
        </location>
    </feature>
    <feature type="mutagenesis site" description="Abolishes catalytic activity; when associated with D-252." evidence="3">
        <original>S</original>
        <variation>A</variation>
        <location>
            <position position="248"/>
        </location>
    </feature>
    <feature type="mutagenesis site" description="Abolishes catalytic activity; when associated with A-248." evidence="3">
        <original>E</original>
        <variation>D</variation>
        <location>
            <position position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="Q03471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="Q9UR08"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="15186158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="16345540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="24239699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="6">
        <source>
            <dbReference type="PubMed" id="26274339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="7">
        <source>
            <dbReference type="PubMed" id="27921136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="8">
        <source>
            <dbReference type="PubMed" id="8440737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="9">
        <source>
            <dbReference type="PubMed" id="15186158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="10">
        <source>
            <dbReference type="PubMed" id="24239699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="11">
        <source>
            <dbReference type="PubMed" id="27921136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="12"/>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDM31315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="342" mass="39192" checksum="ACFBD63F4FF9BB03" modified="2014-04-16" version="1">MATSTETISSLAQPFVHLENPINSPLVKETIRPRNDTTITPPPTQWSYLCHPRVKEVQDEVDGYFLENWKFPSFKAVRTFLDAKFSEVTCLYFPLALDDRIHFACRLLTVLFLIDDVLEHMSFADGEAYNNRLIPISRGDVLPDRTKPEEFILYDLWESMRAHDAELANEVLEPTFVFMRAQTDRARLSIHELGHYLEYREKDVGKALLSALMRFSMGLRLSADELQDMKALEANCAKQLSVVNDIYSYDKEEEASRTGHKEGAFLCSAVKVLAEESKLGIPATKRVLWSMTREWETVHDEIVAEKIASPDGCSEAAKAYMKGLEYQMSGNEQWSKTTRRYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q583</accession>
    <name>W6Q583_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WD40/YVTN repeat-like-containing domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S02g001660</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q583"/>
    <dbReference type="STRING" id="1365484.W6Q583"/>
    <dbReference type="OMA" id="CWHLNGD"/>
    <dbReference type="OrthoDB" id="308690at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990811">
        <property type="term" value="C:MWP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990810">
        <property type="term" value="P:microtubule anchoring at mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052778">
        <property type="entry name" value="Centrosome-WD_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16220">
        <property type="entry name" value="WD REPEAT PROTEIN 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16220:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN WRAP73"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM31510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="473" mass="51833" checksum="CA4A4F1A8E3F9BE8" modified="2014-04-16" version="1">MDASTGSGGPLNLCLSEDGLYAAHVSGKGLIVHSDVASENKEVQIARIKEIPLKSLKYFNVESSRTSDDEVVSRRLLSANDNRISVWQFTPLEILAEIENIEPGSLAVDFGADENEVLVFHAWNTKLSVHSLETGRSSVIKTPKFAHHLGFGYRPRTRHLAILLKPETSDLLTVHEPRSYELVNRTVLSTIDAQGLKWSPDGKWIAIWDIASAGTKVLVFTADGQLFRTYSGPSGVDDSFDLGVKQIEWSPAPNKGVSGILAVGKVNGNIDLLRTRTFSSATTLSHVFQTDQQCLNIWRERYTSAAGDAEYAEASCSSALSMSPESAGPPRGVLTMTFSPDGHLLATVDTARQNVVWIWSLEGTPTLVSALVHEQPVRQIVWHPSTPQLLINTITNTLPAIRWWSPSGHPLIARVPIQRNESGKYDVRWVAGTNPNSPFWFSSPEQHVIGYLSTLDGAVEFEVLNSVSSKSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q6I6</accession>
    <name>W6Q6I6_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Histone-fold</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PROQFM164_S02g002459</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CENP-T/CNN1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q6I6"/>
    <dbReference type="STRING" id="1365484.W6Q6I6"/>
    <dbReference type="OMA" id="GRMQRET"/>
    <dbReference type="OrthoDB" id="10071681at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051382">
        <property type="term" value="P:kinetochore assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22920">
        <property type="entry name" value="HFD_CENP-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000105">
        <property type="entry name" value="Inner kinetochore subunit cnp20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028255">
        <property type="entry name" value="CENP-T"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035425">
        <property type="entry name" value="CENP-T/H4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46904">
        <property type="entry name" value="CENTROMERE PROTEIN T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46904:SF1">
        <property type="entry name" value="CENTROMERE PROTEIN T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15511">
        <property type="entry name" value="CENP-T_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CENP-T/Histone H4 histone fold" evidence="7">
        <location>
            <begin position="354"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="115"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="211"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="16"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="44"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="131"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="158"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="227"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="250"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="280"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="321"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF15511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM32308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="462" mass="50912" checksum="880BED3929A46481" modified="2014-04-16" version="1">MSTSTPNARGRRSPFGTATPSGETTLTGLQRLPIHTRYPLTPSRLVTATTPGTQRSASRYTPRPRGVGAPATPHVIRARQQRAANTPGRDRRRSGRVQRETTFDILRNLGKALAPVSQPIRSSPQEKPEPIEEPIDEFEQLDNEPEIERPRLSLPIQESEEEGDEVSPEMNPPRMSLAFAEEDMDMTYRSVEYPRDASVRDRDRLSMMSRATGRISGDFDETRLESDDADETGIVGEDDEAEDTMMSGGDFDRGGETEDLGRFHFDLNFPSPAAAPLEYPADEDMNDMEGFELSTAEQPQAPSDDDDDDVGGDFGFGLEFPPAASPSESPGIVGGGLRDEAIPAQRKQKKISRHGIPVPNLPAGVVKKLATRFARSGAGSRAKINKATLAAIEQASSWYFEQASQDLAAYSKHAGRKTIDESDVTTLLRRQRHINKTTTVFSLAQKHLPKELQQDMRLSMPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q6I7</accession>
    <name>W6Q6I7_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S02g002111</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q6I7"/>
    <dbReference type="STRING" id="1365484.W6Q6I7"/>
    <dbReference type="OMA" id="YMGMYPA"/>
    <dbReference type="OrthoDB" id="4185910at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="347"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="363"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM31960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="396" mass="44513" checksum="49B6CCCC3F292E9C" modified="2014-04-16" version="1">MQYTTPRPDFVQSQQHPPSFLLRPRPRFCILRPGGFWTPLIALDELPSWLEVCNWAPDMYMGMYPASMTFIPREGEYDVVCHHCSYGVDSLHQSVSRNDSPVAANKPCPTKDCQEQPASPSTQHTEAVSLPTVLHHAPPSHFLEQPPFSAILQAPFVGMCVLDMNSHYPDIASGPAGMQRRMSIENSLPPHIFGTVGVGSPPLSTTNSVNTRRPESPYPHAHDGPFAKPQRVASLQNESVASMQSGSVASTRSLTVAAIEQMKRMRRRKLSRGSSLYASISVAEAKSLSQVSDSKVSKVSKANSKVSKISSIRVISRHHRKVILRRRRAEERKFQESPLSISMEALNLKPEQPNSATKRRDRRERMMQRRKQSDRGKQPYRNMMRIPNWSPGMCKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q6K0</accession>
    <name>W6Q6K0_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S02g000028</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM29879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q6K0"/>
    <dbReference type="STRING" id="1365484.W6Q6K0"/>
    <dbReference type="OrthoDB" id="4507626at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM29879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="297" mass="32908" checksum="FF59DFDAC00DF3D4" modified="2014-04-16" version="1">MARNLYKFVADIDDNLVAPENFYKGLYNLYNRLLETSGIPPQNQLPSYLGNGQEALGPHPQLLAAHCIRGICGLGSDQFRETAFDYEASTSARKETESNASYSLLVAALRGLAFVTDSEACDSEMGSSPLVAQKMAQDMLIGAFFSTRGLKDLTLGGLSSPQSVLNQQELEEEEEDRVDISKFSIGAMVEWSFGTGRRTAEEADSYRGWKRALENWLLLLDNDNFEKLLPRLSEEQSYSARILMEWWNGVIDFEPATQESRDIVYRSAASGAAPRDSGAVTQQSISRIQAHIKASIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q6X6</accession>
    <name>W6Q6X6_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tetratricopeptide-like helical</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S02g001887</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q6X6"/>
    <dbReference type="STRING" id="1365484.W6Q6X6"/>
    <dbReference type="OMA" id="LNGWGIE"/>
    <dbReference type="OrthoDB" id="2384430at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010972">
        <property type="term" value="P:negative regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052945">
        <property type="entry name" value="Mitotic_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43628">
        <property type="entry name" value="ACTIVATOR OF C KINASE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43628:SF11">
        <property type="entry name" value="PROTEIN DSF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="389"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="695"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="174"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="293"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="389"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="418"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="437"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="491"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="721"/>
            <end position="740"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM31736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="740" mass="81086" checksum="2FA8D41210EA8D32" modified="2014-04-16" version="1">MDMRGKLGEYRSNSHDNTLRSGSPRVAHFDGEVPPALSPLDAFAAQSRFLARQLDESRRGDRRMSRLPPASVARSLSQGRPGFYRSKSSVDPRTRTELTRKPTQKGLPEYEEPKHRPISEHPRFSSISNATTEASFYEDNDNVTPRTATPNISGEAHEIPRTESPEDFTSRPSGAEGAPVVVAVADPQGSSIDSSTSRLHIPRTLAPPVSPRTRPSSSAKVTHHESSDDEYSSSNGGSTFSKPRKLSDGSAVSLPYSPMSTFPARPHPRSPSLSSETSGTGTNHLPRPSFNFSRPLSRSSTTLSAPGSSTPTEPILASESNHMTRRGKPTPLLLQLSTEDAAAVEAMDGEPSSAMSSYMYTKYALPRGRFLSRDSVVFAGLQTPHFEWEEPIFEKTPPRHSEEPIRLARTPSPTPPRQLEHSPKPHSMHEVPASKPQSPPQSPPHPQRQPQPQLQPQTLKSRPVPDSPVEPVLRPSAESTRPTNNDRDETVSSADSASTVRPQAPTAQVSASGLTADEHVAKGIECHERGSLSESTYHLRIAAKQDHPTGMLLYALACRHGWGMRSNEKEGVRWLRKAVDSVGLDMLADPDAPGASKAKELQKANRVQFALSIYELGVSYLNGWGIKQDKAYALRCFEIAGQWGDVDAMAEAGFCYAEGVGCKKDMKKAARFYRQAESKGMSMVGNSWIYKDKYNEESNGRAPSGRSRGRNASGEKDNKPRSKSRTRSIFQRKKSNISEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q7X3</accession>
    <name>W6Q7X3_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Mitochondrial carrier protein RIM2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">RIM2</name>
        <name evidence="12" type="ORF">PROQFM164_S02g000493</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q7X3"/>
    <dbReference type="STRING" id="1365484.W6Q7X3"/>
    <dbReference type="OMA" id="IACLIAY"/>
    <dbReference type="OrthoDB" id="269120at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015218">
        <property type="term" value="F:pyrimidine nucleotide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990519">
        <property type="term" value="P:pyrimidine nucleotide import into mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049562">
        <property type="entry name" value="SLC25A33/36-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45829">
        <property type="entry name" value="MITOCHONDRIAL CARRIER PROTEIN RIM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45829:SF4">
        <property type="entry name" value="MITOCHONDRIAL CARRIER PROTEIN RIM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 10" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="29"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="139"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="252"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDM30344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="344" mass="37213" checksum="C871AD33B9129CE3" modified="2014-04-16" version="1">MGGNAQTQYAPSDGGEEGIPVEMPTKKAVSSWVHLLAGASGGMATAIVTSPLDVLRTRLQSDFYQPQKGSDASLPQTSQRSSHKTLRIINSIYRAEGWRAFFRGLGPSMAGVVPATAIKFYVYGNCKRVGAQLMGHTEDSAIVHAQAAICAGLATSTATNPIWLVKTRLQLDKTQTHTGGPSTRRYRNSVDCIRQVMRNEGLGGFYRGLSASYLGSIETALHLVLYEQLKTRLNRSLEATEGPRTPFWNEVFHWVSTSGAASSAKLVAGLITYPHEVIRTRLRQAPVEHGQAKYTGLVQCFSTIAKEEGMAGLYGGLAPHMLRSLPSAIITLGVYEFVLRVTGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q8V8</accession>
    <name>W6Q8V8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Beta-ketoacyl synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PROQFM164_S01g000001</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="8">In the C-terminal section; belongs to the NRP synthetase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1365484.W6Q8V8"/>
    <dbReference type="OMA" id="VAQFGSH"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901336">
        <property type="term" value="P:lactone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009403">
        <property type="term" value="P:toxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05930">
        <property type="entry name" value="A_NRPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19532">
        <property type="entry name" value="C_PKS-NRPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000019">
        <property type="entry name" value="Polyketide synthase type I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049552">
        <property type="entry name" value="PKS_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF20">
        <property type="entry name" value="HYBRID PKS-NRPS SYNTHETASE APDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22621">
        <property type="entry name" value="CurL-like_PKS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21089">
        <property type="entry name" value="PKS_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="12">
        <location>
            <begin position="9"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="13">
        <location>
            <begin position="951"/>
            <end position="1251"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="11">
        <location>
            <begin position="2394"/>
            <end position="2471"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="11">
        <location>
            <begin position="3545"/>
            <end position="3625"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="9">
        <location>
            <begin position="951"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="9">
        <location>
            <begin position="1098"/>
            <end position="1251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="2485"/>
            <end position="2505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="2519"/>
            <end position="2567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="2526"/>
            <end position="2539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="2549"/>
            <end position="2558"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="9">
        <location>
            <position position="983"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="9">
        <location>
            <position position="1158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDM26192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="3980" mass="438079" checksum="4C26969ACBA692A7" modified="2014-04-16" version="1">MTGGLQHTGEPIAIVGSACRFPGDATTPSKLWDLLRSPRDVLSEIPESRFSTKAFYHPDGLHHGTTNVRHSYLLSDDHRLFDAQFFGTKPVEANSIDPQQRLLLETVYEGLETSGIPMEKLQGSNTGVYVGLMTNDYADMLGRDVQNFPTYFASGTARSILSNRVSYFFDWRGPSMTIDTACSSSLIALHQAVQSLRSGETDVAVAAGTNLLLGPEQYIAESKLKMLSPTGRSRMWDKDADGYARGDGIAAIILKPLSAALANGDHIECIVRETGANQDGRTKGITMPNPMAQADLIRTTYARAGLDLSNPTDRPQYFEAHGTGTPAGDPVEAEAISTAFFGQAAKYQRDSNREHPLYVGSIKTVIGHTEGTAGLAAVLKASLALQHAVIPPNLLLNELSSTVLPFYNDLEILQVAKEWPQLSENTPRRASVNSFGFGGANAHAILEEFDTRLLACGQNAAHDSSGAVLPFNFSASSEKSLLTNIAAYSAYLRNNSDVNIRDLSWTLNCRRSTLPVRLSVSASSLGELAAGLDEAVLSLAITPSTQTGSILEPKLLWVFTGQGAQWARMGAELLESSPMVSDCIARLDRSLRDLPTEHRPVWSLRGELVKDKFSSRIGEAAFSQPLCTAIQIALVQLLRAANVKPTAVVGHSSGEIAAAYAAGYLNEEDAIRIAYYRGWSLQYTTSQGGQIGAMMAAGTSFEDAKELCEMPSLENRICVAASNSSASVTLSGDADAIDEAREILEDEKKFARLLKVDKAYHSHHMLSCAAPYIAAIRTCGITVQRPPSGSATWISSVYGENIDSVDENLADTYWSNNMVKPVLFSQAVTYAVGAAGPFDMALEIGPHPALKGPSMQTIQEVSGQTLPYTGTLNRGKKDSEAFSSALGALWIALGEGVVDFAGFEMKAMQNQNTRSPELIKGLPSYSWDHDRVYWHESRSSTAIRTEKEPFHPLLGVKCPDGTDNELRWRNYLHPREVPWLAHHQVQGQMVFPAAGYISAAVECIIQKYGLGSVQLIDFHDVVIGQALVLEENGGVETIFRLSIDQVQADCVSASFACHSDANKGSSNMSLHASAAIQIILGDPRHDILPPHAHPQGSFLDLEADRFYNSVSELGFGYTGPFQALFNLRRKMDEASGLIAVPVDSKTERPLIIHPASLDGAIQSIMLAYSFPGDGRLRTLYLPTRIDRLRLNPTACVALGACGTDLPFYSAVTDARFAELSGDVDIFSADGRHTLVQLEGLHTTPLSPLTSSNDVPFFTEVVWDVDRPTLRQLKKAEGMLPQEGSLGVDLERVAHFYLKNLENSLQDFDHANATWDHTRFLSYVEHCTTSVANGKHKFAKAEWANDTMDDVAPILNRHSDCIDIKALCSVGENLPAVIRGDQNLLEILMRDNMLAEFYAKTLGIDAYLETIAQTARQIGHRYPHVNVLEIGAGAGATSERVLRAMGSSFTSYTYTDILDSQFDNARERFSDYQSRMAFKLLDIEKDIGEQDYEEGCFDLVIAPLALYATRNLEATLTNVRRLLKPGGYLVMLELTDSDVMRFGLIFGGLPGWWLGYKEGRTLSPCISEEKWEGLMQKTGFSGFEALLSSSRTSPLPFSVMITQAVDHRVNFLRDPLAANHTPLGVNSLTIIGGKTSLTTDIVADMKTAVRPHYSNIYTAGSLDDLVSANLPVMGSVISLIELDGPVLRHMSPNNLRSFQELFKQSKNVLWVGHGAQGENPYGNMFTGVQRTLAMEMTHLHIHFLKLRSLYDADSNIIATKLLHLEAAEIWDQSGQLDGMLWSNERELLLENGNFKVPRFRLNSGRNDRYNSSRRLIIKEVERKKSVVTIRPTEIGYQIEEKDLQDSPSFPDDVHIDVAHSFLRAVRITPTDNYFLLVGKNKWNGERVVALSHTLDSQVRVPHGLTVRCGDSEELGIRSILTLYSHFLALSMLQQLQPGTILAVLDPGFSLAPVLTKYAAEKGVQLVLLTTKDGHCSWPWIRIHPNSTRREVLSKLHGNISRLVNMSGSSNVTTLLRTCLRTDCHFESESTLTANISQSQYTSDTGQLAMQLQNTWARAQYDLMPVNMHKFVPLGLEDLIRAQSPLAGQSLIAWGQSQLAVQVRPATKAVKFSKDKTYWLVGLTGGLGLSLCQWMIGQGARYIALSSRNPNIDDQWLQRMAANGCTVRVFSNDITNRESVQATHRNISETMPPIAGVAQGAMVLQDTMFIDLDLPRLEKVLRPKVEGSILLDELFPEDTLEFMVFFSSMAAMTGNPGQVAYNAANMFMASLAAQRRNRGLTAHAINIGAIVGNGYVTRELNMGQQSYLYRVGHSWMSEQDFHEVFAEGVLSCRERVGSAELCCGLRIDDDESKSWVSNPIFQHLVYKSSKLVVTDKKGKSGVLIKTRLFEATSNQEVIEILQDSFVLKLQSALQADPNKPMLDMSPDELGVDSLVAVDLRSWFLKELGVDMPVLKIFNAASIRELLATAAEVLPESLIPNVMAEQAVKSQAHQPNPSTPSPTLPVDKIVPDTRARSMESNFALPDATNAYSGSSATSLVTGDSNSEDNDDTSSSVFTDSSKVGPPKREIQRTLPMSYGQSRFWFLEHLVEDKTAFNITPTFELSGRLRIQEFANAVKATGQHHEALRTFFFTDNERNHIQGVWTKSSLQLEHVAISDKAEVEEAEKQMKAHVFNLSDGEVMRVQLLSLDLEKHWIIFGFHHINMDGISFEVFWSDVEKAYQGQPLSEDGLQYPDFTMRQLREYEEGTWAGDIAYWRAQYTEIPPTIPLLPFALQPMRPKVAQFRSHTAHIRLDVSLSDSIDRCCRMFKSTPFHFHLAVWKTLLLRFFDVKEVCIGLGDGNRTDADILRSVGLFLNLLPVRFSQQPGQSFGESLKEVRNITQGAFSHSRVPFDVILTELNVPRSASHNPLCQTLFNYRPKVEQSRSFCGCVADGALLGGGETSFDLGLDVGNVGAGETLIHLSAQTSLYGMEHAEILVSSYVNILRSFLQNPATRVTWPKLHSKDDIQEALRDEWPVTIVHRLDEVASRYPDRVALRNHDGNSLTYSEVQRRIDVIANELLRNEVGSGTRVGILQSPSADWICSLMAILRVGGVYIPLDTKVGMNRLAMIMKETQAPMVLVDTKSMPDYTLLHTTAKPIDVCSLNASTARPIRNMAVPSQTAVIMYTSGSTGVPKGIMIAHSAYVHHVQSSSVVWELKQGNETILHQSSYAWDASLWQIMVSLCSAATLVITSDLTRGDPIALTRLIASENVTCTLATPTEYLAWLRYGRSHLSNSRLSTAVCGGEFMPSGLIKEIKNLHRPDLKLINAYGPAEISVACSASEVPYDLLGSTSTSPAQALYTLPNYSVYIVDQTLNPVPIGIPGEVVVGGAGVAQGYLDGTKTAERFSSDRYASKFFQEKDWTTIHRTGDRGKLNRDGGLILLGRMDGDNQIKLRGIRINIEEIETAIVSSSAGAITQAVVSVRLDANQSEGDQFLVAFVIMAATHESENILQFLARLSQELPLPPHMKPAAIIPVESIPQNTSGKTDRVAVSALSIPFISSQPPDNSTLTAFEQSLRQLWRQALPRELSSFHSIDSESDFFHVGGSSLALVNLQVLIQEKFGTSMALYQLFEASSLRGMAARIQDISRPALEPDVNWDAEIEVATDLTPPLNYESTHIIASGVKTVVLTGATGFLGKEILRGLIHDENVLSVHCLAVRKRSSGLSELFSHPKVHLHYGDLGAPQLGLSESEIKSIFSCADIVIHNGADVSFMKTYQTLKLINVASTKEIVKLALPRRIPLHFVSSAGVARLTGQESFGEMSVSSYPPPSRPTDGYIAAKWVSEIYLEHVNRRFGLPVWIHRPSSITGTDAPELDLMGNVMRFTKETQKVPDSSSWSGVFDLVSVQSAARQLLEAVYQSGIATTEAVTYLYESGETKIGRDEIMPLMESSSGQQFQVVSLDEWVSAAEQAGMSVLLGEYLRRASDGQVLLPRLIKNSRFSEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q8Z1</accession>
    <name>W6Q8Z1_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S02g003285</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM33133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q8Z1"/>
    <dbReference type="OMA" id="TKVRCYG"/>
    <dbReference type="OrthoDB" id="2590011at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050936">
        <property type="entry name" value="AP-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621:SF6">
        <property type="entry name" value="AP-1-LIKE TRANSCRIPTION FACTOR YAP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621">
        <property type="entry name" value="TRANSCRIPTION FACTOR KAPC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="53"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM33133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="425" mass="46616" checksum="E2D710A116036E15" modified="2014-04-16" version="1">MAVSGGVYPMDHAMGYPEEPQTPSNKGFGAEIFKIFGGGGSGSATSGTGPKKTTRDGQQPKRRGPKPDSKPALTRRQELNRQAQRTHRERKEQYIRALETEVSRLREAYTTEIAEANASIQQHKEMMHSIREENEILKEILAASGIQYEADLERRRAERPPMMSFQSPVTVAGSSNASQIAPLANSTSNPNTTPATTISSDLSPRANGMDHSSISPPIGYAPQQQVYHTSVGGHSMSMDHSSCAPVDTMQPMPVTRGGVFETDPQLQVDFILTLEGPCREHTDYLCRRSVTEADDEDMPFSGHALMATCPPPSYIAKTTPEQPYPHKAPDLPHANLSTLLNLSRQLVTEGQITPIMALQCLKNHDLYPTLRRDDIKIIIDTLNTKVRCYGFGAVVEDFELIDCLSSVLGTKVDLSMSAPDDSMYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q9A6</accession>
    <name>W6Q9A6_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WD repeat protein 23</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PROQFM164_S02g003141</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q9A6"/>
    <dbReference type="STRING" id="1365484.W6Q9A6"/>
    <dbReference type="OMA" id="RIWINEQ"/>
    <dbReference type="OrthoDB" id="1577640at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050349">
        <property type="entry name" value="WD_LIS1/nudF_dynein_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44129">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN POP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="340"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="382"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="424"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="466"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="508"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="563"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="598"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="640"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="682"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="724"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="766"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="808"/>
            <end position="849"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDM32990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="949" mass="105752" checksum="1365C061812C69D9" modified="2014-04-16" version="1">MCRDWPGDDIIQQLVKMSVPLFICAATVCRYIENLKWEPASRLTELLKDQAKYAAKMDKTYLPILTQLIDDQDNNESEQQQLLQEFQEIVGVIILLAVPLSINALSLFLGLEPDLISNRLDLFQSVLSVPKKRDLPVRILHLSFRNFLVRSQSRFLVDEPKKHMDIAMRCLITMRGRLKKNICNLKGYGIQRTEIDAMSIHQHLPPELQYSCRYWVHHLAQSKNFAAAIEEIFLFLREHFIHWMEAMSILGVVSEVLEIIDQLQLVISDYKITNLLHDGRRFVLKNRHIADEAPLQLYHSGLLFAPRLAIVRREFEEELPSWICRFPKVEEIWSSEMQTLEGHSECVQSVAFSPDGRILASGSSDKTVRLWDTATGVLEQTLDGHSKSVQSVAFSPDGRLLASGSSDKTVRLWNIATGELQQTFDLYSESVQSVAFSPDGRHLASGSNDGTVRLWDTTLGTLQQTLYGHTDNVRSVTFSSNGQHLASGSNDRTIKLWDTATGALQQTLRGHLDSVHSIAFSPDCLLLASGSRDETLKLWDTDTGALRRSLDGHSDSIWYPDWVASVTFSPDGRLLASGSNDRLVRLWDTATGVLQQALEGHSHCVQSVAFSPDGRILVSGSKDKTVRLWDTTTDTGQQTHDGHSDWVWSIVFSPDGQLLASGSSDKTVRLWDTATGALLQTLKGHSRCVQSVAFSPDGRILASSSNDETVRLWDTATGARQQILKGHLGIVWSVVFSPDGRLLASSSSDKTVRLWNVAIGAWQQILDGHSDEVRCVTFSLDGRYLASGSKDRTVRLWDTATGALQQVLSGHSDNVRSVAFSSNGRLLASSSDDKTVRLWDTATGALRQSLGAHGLVTNLEFVRDDSHLSTNLGYLKTQSGCDNHTSNLSQGEAGIFILNRQWITLHRRKVLWLPPEYRPWCSAINGTTLALGHESGRVSFIGFCDSGRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q9D6</accession>
    <name>W6Q9D6_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S02g000954</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q9D6"/>
    <dbReference type="OrthoDB" id="10601106at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM30804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="51" mass="5808" checksum="735D36197C001001" modified="2014-04-16" version="1">MVKIKHGATRGINKSNENDELARAINGYKAMGISESYRWPEDESKAHGWIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W6QAB5</accession>
    <name>W6QAB5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S02g001259</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QAB5"/>
    <dbReference type="STRING" id="1365484.W6QAB5"/>
    <dbReference type="OMA" id="QSYDDGQ"/>
    <dbReference type="OrthoDB" id="5296805at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM31109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="316" mass="36290" checksum="34D345034293BFFD" modified="2014-04-16" version="1">MSPVSHPKQREAKSVMSRGVCDKEETLYLKWSLVLSPSELLKELVGDSEHARALFHGMRRQVRSIRRRSQSYDDGQVTIYDRVLLRLYDEGHTMKHYGLLGFYLTEHLGTKNCKSEEEKNTLVAAHLAAQRILDNGPISEIPVIAADNVEGITKDARTSKSPQSSGTSNSHHIDKLIQVYQKAKADYYILEVTESHRERTNSVRFLRDTAENLLRYLKSVNQGHDLIPEIEGIIRVSQAHANELAGGRKRKFEHVDNDSRGSPSLSPYRPYGFHRDQRRGHKRRDRYVPDSVTWEYSHVDRRAGRDSRALDSYRPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W6QAH6</accession>
    <name>W6QAH6_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fatty oxidation complex, alpha subunit FadB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S03g000139</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QAH6"/>
    <dbReference type="STRING" id="1365484.W6QAH6"/>
    <dbReference type="OMA" id="YAGINKG"/>
    <dbReference type="OrthoDB" id="9988102at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015814">
        <property type="entry name" value="Pgluconate_DH_NAD-bd_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09130">
        <property type="entry name" value="DUF1932"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphogluconate dehydrogenase NADP-binding" evidence="1">
        <location>
            <begin position="6"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphogluconate dehydrogenase NAD-binding putative C-terminal" evidence="2">
        <location>
            <begin position="223"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM33415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="329" mass="34843" checksum="23093FE6FA05B413" modified="2014-04-16" version="1">MRPVTVGIVSIGDMGLGMARLLKAHDYRVVTVAEGRSEHTLARIHSAGIEILPSDQALVIQADYVLSIVPPRNAVATAGRIAAACALPSTGSLREAVEDVENPPKRSKLYYLELNAVPARLASEMAAQFDEPTTTDGGRGCHFLDGGIIGAPPSQSTQDGSWKKPSVVLSGLVDLAPGFATLAGVLNIRLVSSRIGAASTLKLSFAALTKGLTALSILSFSTAQRESMLPELLALLEEYSPRTAALATNGVIGMSPKAYRWEDEMRGIGEMFDAEGGWNGVGADVYGGFAEIYRTIAEDTVLGEERVEHRVRGITIEDAAQIIAQRKGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>W6QBZ3</accession>
    <name>W6QBZ3_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Quinate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PROQFM164_S03g000305</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Integral membrane transporter that imports quinic acid to be catabolized as a carbon source.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Interacts with creB.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QBZ3"/>
    <dbReference type="STRING" id="1365484.W6QBZ3"/>
    <dbReference type="OMA" id="CWIRQLE"/>
    <dbReference type="OrthoDB" id="508119at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000026">
        <property type="entry name" value="MFS quinate transporter QutD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF34">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0672">Quinate metabolism</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <keyword evidence="5" id="KW-0832">Ubl conjugation</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="21"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="123"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="193"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="282"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="324"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="352"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="384"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="455"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="14">
        <location>
            <begin position="24"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00043213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CDM33581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="535" mass="59657" checksum="97DE6DCE4688A007" modified="2014-04-16" version="1">MGILTLAEDRPTPKSVYNWRVYALAVIASCGSNMIGYTSAFIGTTITLSSFMKEFGLDEMSSTQRSLISENIVSLFIAGAFFGALGTYALGHFIGRKWSLAVAATVFFLGAGLQLGANSARGLGILYAGRVLSGLGTGVASNIIPIYLSELAPPAIRGRLVGLYELGWQIGGMLGFWINYGVEQHMPEVHEQWIIPFAIQLVPSGLLFIGALWIKESPRWLFLKDRRREAMKNLCWIRQLEADDMYITEEVAAIDQALEHQKTSIGIGFWKPFQALATNKSVMYRLMLGCMLFFWQNGSGINAINYYSPTIFKSIGVDPNTVNLMTGIFGVIKAVMTFVWLLFLVDQFGRRNLLLVGAVTGSICMWVIGAYICVVKPEDNVATSLNGGGIAAIFFFYLWTAVYTPTWNGTPWVINSEFFDPNFRSLAQAATTASNWLFNFLVSRFTEQMFATMHYGVYFFFASLSFLAFFFAFFLIPETSGVPLEKVDRLFDCKPVWRANKILKAALAEEEEQFRYEVKEASYHEENTGSIAPTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W6QCF0</accession>
    <name>W6QCF0_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S03g000879</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Cyclase 1 superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QCF0"/>
    <dbReference type="STRING" id="1365484.W6QCF0"/>
    <dbReference type="OMA" id="PDKRRFW"/>
    <dbReference type="OrthoDB" id="5396at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004061">
        <property type="term" value="F:arylformamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:L-tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.50">
        <property type="entry name" value="Putative cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007325">
        <property type="entry name" value="KFase/CYL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037175">
        <property type="entry name" value="KFase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34861">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34861:SF9">
        <property type="entry name" value="CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04199">
        <property type="entry name" value="Cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102198">
        <property type="entry name" value="Putative cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM34155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="326" mass="36763" checksum="2A0F52CF48A615B6" modified="2014-04-16" version="1">MSGIPNLPETFDDLPDKRRFWPGTAGSEEEGLGMLRLLTPELVARAAQTQIQTGERVCLNWNMENLNPPGFGRKPFEHRVKWVAEGVAFDDEYHFNPQQSSQWDGLRHHNAPAPTPEDEDRRLFYGGTTAEEILNENSSRIGIGFWAKKGIAGRGVLIDYVSYAERNGLSVNALSRQVISLDEVQKIARECNIIFQKGDIFFLRVGLPGTWERMSAEERVTYSQQGMPQHAGIEQSERVLRFIWDNHFAAVASDAVSFEVFPPLNPEFDLHHHLLAGWGVPIGEMFDLDELAATCKRLKRWSFFISSSPLNCSRGVSSPPNCMAIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W6QCI3</accession>
    <name>W6QCI3_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">40S ribosomal protein S4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">rps4a</name>
        <name evidence="9" type="ORF">PROQFM164_S02g002040</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the eukaryotic ribosomal protein eS4 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QCI3"/>
    <dbReference type="STRING" id="1365484.W6QCI3"/>
    <dbReference type="OMA" id="GHIQLNL"/>
    <dbReference type="OrthoDB" id="1109245at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06087">
        <property type="entry name" value="KOW_RPS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000005">
        <property type="entry name" value="40S ribosomal protein S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.740:FF:000001">
        <property type="entry name" value="40S ribosomal protein S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.290.10:FF:000002">
        <property type="entry name" value="40S ribosomal protein S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="entry name" value="RNA-binding S4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00485">
        <property type="entry name" value="Ribosomal_eS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000876">
        <property type="entry name" value="Ribosomal_eS4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032277">
        <property type="entry name" value="Ribosomal_eS4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013845">
        <property type="entry name" value="Ribosomal_eS4_central_region"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038237">
        <property type="entry name" value="Ribosomal_eS4_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041982">
        <property type="entry name" value="Ribosomal_eS4_KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013843">
        <property type="entry name" value="Ribosomal_eS4_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018199">
        <property type="entry name" value="Ribosomal_eS4_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11581">
        <property type="entry name" value="30S/40S RIBOSOMAL PROTEIN S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11581:SF0">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN ES4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16121">
        <property type="entry name" value="40S_S4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00900">
        <property type="entry name" value="Ribosomal_S4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08071">
        <property type="entry name" value="RS4NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002116">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00528">
        <property type="entry name" value="RIBOSOMAL_S4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6 7" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="RNA-binding S4" evidence="8">
        <location>
            <begin position="41"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR002116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM31889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="265" mass="29966" checksum="B08AD1968F5AC5AD" modified="2014-04-16" version="1">MRGPGKHQKRLSAPSHWLLDKMSGTYAPKASPGPHKLRDCLPLIVFIRNRLKYALNGREVKAIMMQRLVKVDGKVRTDTTYPAGFMDVISLEKTGEHFRLIYDTKGRFTVHRIQAEEAEFKLCKVKRVQLGKGGIPFLVTHDARTGQWKHIRYPDPAIKVNDTVKVDIATGKILDFVKFDTGVVIMATGGRNMGRVGVITHRERHDGGFNIVHVRDALDNQFATRESNVFVIGQEKPWVSLPKGKGVKLSIAEERDRRRAHELAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W6QCJ6</accession>
    <name>W6QCJ6_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="4">KRR1 interacting protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S03g000500</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the KRI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QCJ6"/>
    <dbReference type="STRING" id="1365484.W6QCJ6"/>
    <dbReference type="OMA" id="WDNYDPR"/>
    <dbReference type="OrthoDB" id="10252032at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018034">
        <property type="entry name" value="Kri1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024626">
        <property type="entry name" value="Kri1-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14490:SF5">
        <property type="entry name" value="PROTEIN KRI1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14490">
        <property type="entry name" value="ZINC FINGER, ZZ TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05178">
        <property type="entry name" value="Kri1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12936">
        <property type="entry name" value="Kri1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kri1-like C-terminal" evidence="3">
        <location>
            <begin position="471"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="50"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="285"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="384"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="536"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="50"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="76"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="286"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="386"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="411"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="435"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="453"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="542"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="598"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM33776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="607" mass="69746" checksum="9EB91009195FE8FB" modified="2014-04-16" version="1">MEPPSKKMRKLLDQDSDSDSGDDAGGVLLGKQSSDTGFTINEDYARRFEHNKKREEVARLEAKYGKSSSLGNRPDEDSEDSDSEEEDDNAELATVALDAEISATLNAIRSKDPRVYDKDASFYSKYDPEEAAAGKGPKEKSMTLRQYHTENLLSGVNPAEEESTPRTYAQEQADLKNAIVKEMHGAADKSDEEMEDADEFMVRKPGQDISLPKSEIKLDIENADKDPETFLSNFLSARAWIPTDRPELHPFDSDEDDDVDRAEAIEEAYNFRFEDPNKMNEVIVTHSRDLTNKQSVRREEKSSRKKIRDAERALKDEEKKQRETEKNRLRKLKTEELQKKVEQIKEVAGLRASEFTDDDWSRFLDASWDDSNWEAEMQKRFGEEYYAGEEGEDSENEGGKKKKHPKKPTWDDDIDIKDLVPDYEDEEAKPTVELSEAEDEDDDEASGSKKKSKAEEKRIQKREARKDRLRIDDAVERNLDLDITLLPGATKKNATKFRYRETSPQSFGLTARDILMADDIQLNKFAGLKKLATFREEEQKRRDQKRLGKKARLREWRKDTFGDENGPVFKFGGDVQPSQPKDAVDEDKVDIREGDGTRKKRKRSKKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W6QCV3</accession>
    <name>W6QCV3_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Short-chain dehydrogenase/reductase SDR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S02g002175</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QCV3"/>
    <dbReference type="STRING" id="1365484.W6QCV3"/>
    <dbReference type="OMA" id="AEWDMLM"/>
    <dbReference type="OrthoDB" id="1669814at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24321">
        <property type="entry name" value="DEHYDROGENASES, SHORT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24321:SF8">
        <property type="entry name" value="ESTRADIOL 17-BETA-DEHYDROGENASE 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM32024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="256" mass="26434" checksum="014E216D78C5E746" modified="2014-04-16" version="1">MDSVKGKVYAITGLSGIGLAVARQLHKQGALLSLADLSSQILSAARQIIETDSSSSTASTITTTELDISNASAVQDWIASTVSHFGRLDGAANMAGTIGKNHGTSKFVDQDDAEWDMLMRVNVTGLMYCLRAQLRAITATAPGGKGSIVNASSIQGIKGFALHAAYSTTKHAVSGLTKSVSKEVGPGIRVNAVAPGSIQTPLLDMAKEIQGGISMPPASIPRIGTGEEVAQTVVFLLSDASSYTTGQIVSVDGGWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W6QD90</accession>
    <name>W6QD90_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein kinase-like domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S03g001383</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QD90"/>
    <dbReference type="STRING" id="1365484.W6QD90"/>
    <dbReference type="OMA" id="HENTTRL"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM34658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="326" mass="36010" checksum="882249A68992A2E3" modified="2014-04-16" version="1">MERDQDKRSTRFDMLQAQAHFSSSVTAAETQPHNPTNQPGHAQSPIKYQKSPAAQKDRSRKTLEGPPKTLELPTNVSTGGLAKTLLIRTCSPWETYKPIFTCDLAGIVSISEHRHRGSKVVAIRSSSRMDREDLLHKYTRFDHINIISASECFKDNGVNHYIVDDLPITLEHLVASDAYPSEVQLASILKQVIDGLSYLIECGYEHSSLKCSTTLMSLDGVVKIASLEQTVPYTSERSQSLSLKSLGSLTMELMQKYVKENVGIDDPARWPVDSNAVDFLSSTTSARSVKELTKHPLIAASCSTGSLVGLARLAIVSACTFYSYRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W6QDH0</accession>
    <name>W6QDH0_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Zn(2)-C6 fungal-type DNA-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PROQFM164_S01g001458</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QDH0"/>
    <dbReference type="STRING" id="1365484.W6QDH0"/>
    <dbReference type="OMA" id="VVPQICR"/>
    <dbReference type="OrthoDB" id="3145928at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052360">
        <property type="entry name" value="Transcr_Regulatory_Proteins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206:SF14">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="13"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="52"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM27647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="547" mass="60919" checksum="A36713DDEA4DEF65" modified="2014-04-16" version="1">MSHRIGAVKSRSGCKTCKIRRVKCGEEKPNCLRCSSTGRKCEYESRGVSPWAPSTPSLELSSPNPGRRERRAFEYYFQHVSQHLAGGMNIDFWTGVVPQICRSEPAVWDAMIAISALYENPKQCMDFHFLRDRRNKAHLLDHAQQEALTWYTRSISGVSSQIQRGSADPYIAVISCALFICVETIQGHMEQALELYRQGIILILDLRAQIGHGGISTSKAVLLERSIAPLFLRLGTSSLTISGTQFPTELLAFVETDLSAGFASADSARTIISAIAAEVALFEREAKLHLRAVGADSAVSPEMVAKKEALRARLDQWHRAYTNTCERKNSVSNVSIYPEPILLTHHAATLICVTGCLRQQETVFDIHFKDFVTIVEQSRLILDTSVGPNGAQPPFTFELSVGVPLAMTVLRCRDPSLRRRALDLLRQAPPIQGFFKCAPVAVLSETLMKLEEGYSPALRQVNTVALPHKVEATRSQAALIPEEARIHDYGIFRQNECQPPWITEEDLAPFPHGSNQLYLGFSSNQYDNESSTWRPTFQCVPLVASFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W6QDU6</accession>
    <name>W6QDU6_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S03</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S03g001395</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QDU6"/>
    <dbReference type="OMA" id="WFREDIY"/>
    <dbReference type="OrthoDB" id="5389540at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM34670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="93" mass="11089" checksum="48D4CB39980D93D7" modified="2014-04-16" version="1">MFRTPILGYPLRAIRWFREDIYKNSPEKRSEAETAIKKFYDANKDSMEKRGVSEAVVKGAKYNDPRNLDPKGEYWTVEMIKEDGEFVIKRYIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W6QDY7</accession>
    <name>W6QDY7_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF676 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PROQFM164_S03g001670</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the putative lipase ROG1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QDY7"/>
    <dbReference type="STRING" id="1365484.W6QDY7"/>
    <dbReference type="OMA" id="WSYIRPT"/>
    <dbReference type="OrthoDB" id="5368485at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007751">
        <property type="entry name" value="DUF676_lipase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044294">
        <property type="entry name" value="Lipase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016445">
        <property type="entry name" value="Rog1_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12482:SF62">
        <property type="entry name" value="LIPASE ROG1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12482">
        <property type="entry name" value="LIPASE ROG1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05057">
        <property type="entry name" value="DUF676"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005412">
        <property type="entry name" value="UCP005412_abhydr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF676" evidence="4">
        <location>
            <begin position="302"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="DUF676" evidence="4">
        <location>
            <begin position="467"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="205"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="258"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="334"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="438"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="678"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="943"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="205"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="342"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="965"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="996"/>
            <end position="1010"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDM34943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="1045" mass="115238" checksum="A9EFF410AC051328" modified="2014-04-16" version="1">MLITARTYSASQTPDQGAAQPSNQRSRFHTFSGWETIPVDTKEPTDMLLIHQVGSVRVGEVVRYTVTYTPAADPILPIPSNLYVRVKNTSAIPLRAAYLHGPYTLYAACYPTKFDPNTKYERQDLEGTPQFEPYLKAGGGWDAVIKVPANLQEAHDFGSPGQGGPASGHSVSWIVEIQSQVIFSSSAAVHFELLVGRDEKSLAYSSGGTWSSGNSSPGPPAKLQDHWLPGTRGSQVLASKGVYSKSIALQVDDTTSLWSSPPFPSAKPASKSVERKSHDSQPVCDNPVPEESTEAPMKSAKKKKVHLVLLTHGLHSNLGADMLYLKESIDTGMRNSKKNKRQARDPHASPVVDRENPTSSKSSHTEEQNSQSGDNSDDDDEEQVIVRGFSGNAVRTERGIQYLGKRLAKYVLLLTYPDQPYFPLRGSKPSPFARPFSARKERAEPFSHSAESTPQENAHEFQDEDHAYQITSISFIAHSLGGLIQTYAIAYIQKHSPQFFEQIRPVNFIALATPFLGLSNENPMYVRFALDLGLVGRTGQDLGLSWTAPKVRSGWGAIIAGRGESAKDPGHSDPGSKPLLRILPCGPAYEVLKKFQHRTVYSNVVNDGIVPLRTSSLLFLDWKGLDRVEKARRDNGLVGTMAEWGWAELTGANSKSPRLARHDGELPLNLPMEAGHHHAYSATKVPPRPKDDVSDEDTISPRPAQFLAPSSHVSSNKVSEEGVLKENIPGNTSHSPMDSFFSLFRPTQNKNPPNSKNARIYKRSQTLSTFETGDSDSTMPINHDHDHEGMHTPPKTTFFECAGDLLMPPLPPAEFISDPASRPRTIFHDRIYHPEDIPPPLPVKRRILAFGSPQGKQSNSQNPPADKESGLKVEEKIARAYHRDLTWRKVLVRLEPDAHNNIIVRRMFTNAYGWPVVKHLVDTHFSHTLTAETDDSLKQNMEMAKSPNVGPTSSGDEVEGQSDPVDPKSIRDTDNLPNVSDLHISKDGSSGPSDISRAEDESHIGTRDRNLVSSQDSARWTDREVVEDDSESGFEVKTNAGFRHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W6QE23</accession>
    <name>W6QE23_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S03g001710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QE23"/>
    <dbReference type="STRING" id="1365484.W6QE23"/>
    <dbReference type="OrthoDB" id="566138at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42678">
        <property type="entry name" value="AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42678:SF34">
        <property type="entry name" value="OS04G0183300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="1">
        <location>
            <begin position="60"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM34983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="198" mass="20548" checksum="DDC3A90092832CBB" modified="2014-04-16" version="1">MTINVLTTNAVDLQRLLDENKTTSAQDVEEYLAQIDRYEPALNALISPAPRDKVLATAKALLKDCFVTASELGMSTTAGSYAFVGAKASKNGAITQRLIDAGLIILGKANMTEFAGMKMTMMMPGWSAHGGQTLSPYTPGASSTGSAVAVAAGFSPLAMATETIGSIVTPSTRAGLYSLKPTTGVQDTTGLYTDATTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W6QE40</accession>
    <name>W6QE40_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Mediator of RNA polymerase II transcription subunit 17</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 8">Mediator complex subunit 17</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">srb4</name>
        <name evidence="8" type="synonym">MED17</name>
        <name evidence="10" type="ORF">PROQFM164_S03g001015</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the Mediator complex subunit 17 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QE40"/>
    <dbReference type="STRING" id="1365484.W6QE40"/>
    <dbReference type="OMA" id="AAETKYW"/>
    <dbReference type="OrthoDB" id="5319830at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070847">
        <property type="term" value="C:core mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019313">
        <property type="entry name" value="Mediator_Med17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13114">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13114:SF7">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10156">
        <property type="entry name" value="Med17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 8" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDM34291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="643" mass="72008" checksum="6198BA0D022E7C31" modified="2014-04-16" version="1">MADSFTLPLRPIPEKRERPDTLPVEIAQINNQWGSFREVNEDVLRNKIAEEEEKDGLDEVDESDQDATDLDSTERLEQLYKRRAEITQFAMQAHMETMFALDFVSLLLSKQAPRQAETSMSAFLKQVAPLGSLNAEVVNPPPKPESTIKDISAVSRGWRIQNFNAAANKLLQAASRLETEVASETRYWNEVLAVKDKGWKISRLPRERQSLGVQYGFLEATPVFRNRGLASLRRAEDGALLLDEGLIPSKARFVRVRVIQDGKLSGRSRPTRSTFNGNATIEDRILQARDTVYEEELFHELVREARAIASFGVTTRQNLIQIPASDNLEILLDLVDTDEDTSQPEHDISQQGTSLADGLAHTIRILLAYAHRQNLRRRTMLPLPLTPKTRPVPEHQLIRPALAYIKHMSDVRWLQSLLKDLFGVLQSAGLKPPAYTARVFSTKRQKQTSSAPVVETLIGQFLTPLLSTFHGKLLTPRGSFSIAIHTNLSSTPFGTTFDVSFNMPKYPDLESPGKLSQREEVEAAINHLLLLDVVFTISSNSGSLKSESDKDQAKGSWEAIYPQHGELLIPSSKSESRKKMKIALSRHELSVEIYSVRCIDGTGRGNWEKPSSHSMPHIWKPSPIAGSPNQPSLMDFVSAAVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>W6QED0</accession>
    <name>W6QED0_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Probable protein arginine N-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PROQFM164_S03g001820</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM35093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QED0"/>
    <dbReference type="STRING" id="1365484.W6QED0"/>
    <dbReference type="OMA" id="CTHTKVK"/>
    <dbReference type="OrthoDB" id="7848332at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042054">
        <property type="term" value="F:histone methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016274">
        <property type="term" value="F:protein-arginine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.160.11:FF:000001">
        <property type="entry name" value="Blast:Protein arginine N-methyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000050">
        <property type="entry name" value="Hnrnp arginine n-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.160.11">
        <property type="entry name" value="Hnrnp arginine n-methyltransferase1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025799">
        <property type="entry name" value="Arg_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055135">
        <property type="entry name" value="PRMT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006:SF53">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22528">
        <property type="entry name" value="PRMT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51678">
        <property type="entry name" value="SAM_MT_PRMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="5">
        <location>
            <begin position="67"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="Protein arginine N-methyltransferase" evidence="6">
        <location>
            <begin position="169"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF22528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM35093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="348" mass="39602" checksum="8C8E301F08A53F31" modified="2014-04-16" version="1">MDTGSDSPQGITSSADRMVGMEHSEVRYFTSYDHHGIHEEMLKDDVRTRSYRDSIYQNRHIFKDKIVLDVGCGTGILSMFAARAGAKHVIGVDMSSIIEKARQIVDVNGLSDKITLLQGKMEEVNLPFPKVDIIISEWMGYFLLYESMLDTVLYARDTYLNPGGLIFPDKATMYVAGIEDGDYKDDKIGFWDNVYGFDYSPMKEIALNEPLVDTVEMKALVTDPCPIITFDLNTVTTADLAFKVPYALTAKRPDFIHALIAWFDIEFSACHKPIHFSTGPHAKYTHWKQTVFYLRDVLTVEEDERVTGWVENRPNDKNKRDLDISISYKFETPDATRAAEGGCFYRMC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W6QF55</accession>
    <name>W6QF55_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major facilitator superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PROQFM164_S01g002038</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. TCR/Tet family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QF55"/>
    <dbReference type="STRING" id="1365484.W6QF55"/>
    <dbReference type="OMA" id="MFVGSAF"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000196">
        <property type="entry name" value="MFS toxin efflux pump (AflT)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF199">
        <property type="entry name" value="MFS EFFLUX TRANSPORTER INPD-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01036">
        <property type="entry name" value="TCRTETB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="243"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="270"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="311"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="352"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="378"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="405"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="436"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="505"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="49"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="9"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM28227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="546" mass="59002" checksum="3337B559A78A4DB5" modified="2014-04-16" version="1">MAHSSGMKDFGDEVYTNRDDIPLKEARTGDSDDEEEKQVYPSSSKLAPILIGLCFQSFCIALDNTILSTAVPKITEQFNSLGDLSWYASAYLLTTCAVTLPFGKVYTYYSTKWTYMIALGLFELGSLICAVTPTSKGLILGRAIAGIGSGGLSPGALLVLANSVPLHRRALYFGIIGSTSGIATITGPLLGGLLTDHVSWRWCFWINIPFGVLTGLVILFFFKDSTSPKPKISRLGQLQRMDPLGILAFIPAVVSLLLCLQWGGTKYSWNNARIIALFVLFGVFGFAWCAIQVWKQDDATVPPRLLKNRNVLGAVIHATFLGGSFFVFGYYLPIWFQAVKEDSASQSGINNLPMVVAMIVFSALAGLLVNIVGYYTPLMFVGSAFLTVGSGLCTTFRVNSGYPEWIGYQVILGIGAGIGFQQCINALQTVLPLQDIPIGIAIITFAQSLSGAMFISIAQTVFENRLVASITAYAPNINSDALIKAGAANLSQRVPKNMLPSVLHAYNIAVIQTFYVSVAAALLSFIGAGLVQWKSMKRRQKYDGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W6QFH5</accession>
    <name>W6QFH5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Probable 4-hydroxy-2-oxoglutarate aldolase, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S02g003050</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DapA family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QFH5"/>
    <dbReference type="STRING" id="1365484.W6QFH5"/>
    <dbReference type="OMA" id="GMDACVP"/>
    <dbReference type="OrthoDB" id="191315at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008840">
        <property type="term" value="F:4-hydroxy-tetrahydrodipicolinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00408">
        <property type="entry name" value="DHDPS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128:SF52">
        <property type="entry name" value="4-HYDROXY-2-OXOGLUTARATE ALDOLASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128">
        <property type="entry name" value="DIHYDRODIPICOLINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001365">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00146">
        <property type="entry name" value="DHPICSNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="2">
        <location>
            <position position="147"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="2">
        <location>
            <position position="176"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR001365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR001365-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001365-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM32899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="311" mass="32622" checksum="28EFD0A5C6482D17" modified="2014-04-16" version="1">MTATKLNALPHGVYVPTVAFFKPDEEVDLATVEKHAVYLARSGVTGLVTQGSNGEAIHLDREERKAITAATRGALNAAGYSSMPVIAGAGAASTRETIRLCQDSGAAGADAVLVLPPSYYKTLVSTESMHAHFRAVADASPVPVLIYNFPAVQSGLDLSSDDILTLAEHPNIIGCKFTCGNTGKLARVAAAKPDFLTFGGSADFTLQTLIAGGAGIIGGIANLIPRSCVRVMELYCAGKVQEAQKVQAVVARADWTAIQGGFIAVKTGLQCYRGYGGLPRRPCVVPDAKAVAAIQEEFREAMELEKSLETV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W6QG63</accession>
    <name>W6QG63_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S04</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S04g000664</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QG63"/>
    <dbReference type="OMA" id="EKGFIFM"/>
    <dbReference type="OrthoDB" id="10631516at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM35783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="308" mass="33557" checksum="E6D4E267FD2477DF" modified="2014-04-16" version="1">MADLDPNFIARFMIAWRQVNSATPPSSAPPSGVPPSGASPSSVPPSNVPPSSAPPAYAPPAYTPPAYTQLFTSGQLTNTPFSALHNTVSSTRLGYNRRQHQQGVIGQQVAERDIPIAVNFYLQQSPGETVPIPNASMLITLPPTQRIGFIDLWVRNTLFSALPGIICFRPRLEDKFYLAEAMIKGAGKKLVPRWISGVDAEFEGTVKEFLTKVPAPKLHVVVARYEGAIDNWPDSNIVVRSAGEAEEVSQTPLPSSPSHIWIPPRSFGSPPPVAVIESPTRPRARGRKRARPQAEGPSPRRSQRIRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W6QGH6</accession>
    <name>W6QGH6_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="8">TRAM/LAG1/CLN8 homology domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PROQFM164_S03g001808</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM35081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QGH6"/>
    <dbReference type="STRING" id="1365484.W6QGH6"/>
    <dbReference type="OMA" id="AQWYNGM"/>
    <dbReference type="OrthoDB" id="10266980at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006634">
        <property type="entry name" value="TLC-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050846">
        <property type="entry name" value="TLCD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13439">
        <property type="entry name" value="CT120 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13439:SF0">
        <property type="entry name" value="TOPOISOMERASE I DAMAGE AFFECTED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03798">
        <property type="entry name" value="TRAM_LAG1_CLN8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00724">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50922">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="166"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="289"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="TLC" evidence="7">
        <location>
            <begin position="68"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM35081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="408" mass="46095" checksum="4F7DD5E01E211209" modified="2014-04-16" version="1">MLDPFPPPPEWLRSFVEPYTLRLNCPTLADHIHEVIAAFAFYLFIHTVLSPRLSPILFPQSYNKLTPRTKLNWDIHAVSFVQSIVINVAALWVMFFDKERSSMTSGERVFAYTGACGLIQALAVGYFVYDLIVSIVHVRMFGLGMLFHAVSALWVFSLGFRPFLNYFAPTFILYELSSPFLNIHWFLDKVNMTGSRAQWYNGMALLFSFFACRLVWGSWQTVIVYMDMWNALQQTWSAAAAPLSEPVSINAHVFYPARDGRLCVNEACARANAEITKFKEHTAGGVPTWLVVTYVGSNLILNFLNFYWFSKMVETVLKRFRTPADAAGMKKGTKEPVSAEKDAQLKEDIVHDVVLEAASKLEQQETAILQDELSSLHEKISSSVDSGLGEELRKRRAELVAKLPLPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W6QH83</accession>
    <name>W6QH83_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Genomic scaffold, ProqFM164S03</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S03g000283</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QH83"/>
    <dbReference type="STRING" id="1365484.W6QH83"/>
    <dbReference type="OMA" id="FHRGRNR"/>
    <dbReference type="OrthoDB" id="4369951at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004879610" evidence="2">
        <location>
            <begin position="23"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="275"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="179"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="275"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="293"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="318"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM33559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="462" mass="43471" checksum="4BF93F5DCBF913EE" modified="2014-04-16" version="1">MFSTRCLVLLACSLTLLRGVVAVPADVALEQPGLEDRRREERDFGLQERHGHPELESSLLSILTEKLATKTAPGGGGGGGATTVPGEGGATTVPGGGGGTTVPGEGGGTTVPGGGTVPGGGGATTAPGGGTVPGGGGPTTAPGGGTVPGGGGATTVPGGGGGTTVPGGGGGTSPGGGTTATPTGGTETSPTGGATTTTGPAPGGNTSPTTSEQPSTTSPTGGGGVSPSPSPSVTTGGGVPPVCPTPSTSRETTVVPVTVTCPAVVVSTATTTVTVTSGPALSGPTGCPCPTEGPGGGPGPGPGTGTTGGPGAGTSEVSPSGTATASTTTTSEVSPTHSVTAPTTTSSEVSSSHSVTVSPTRTGTLTRTLTQTRTSTPLVPTTRSRTTVTTTTPGTLVTLPTTSHVAPGTPGANATATPLFTNTSTPSNATTSAVNITRIATETATEPAPAFLPRFYRGRIRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W6QHL5</accession>
    <name>W6QHL5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S01g002918</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QHL5"/>
    <dbReference type="STRING" id="1365484.W6QHL5"/>
    <dbReference type="OMA" id="RSANYTD"/>
    <dbReference type="OrthoDB" id="3437411at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM29107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="562" mass="64092" checksum="04439C0F459B37F9" modified="2014-04-16" version="1">MPLQNLPPEVLVKIINSLPTMGDVVALSHQNRGLHSISDVSNRQKYHEFQLGREGQESFTVQLQAGQNMLLEILANPSLGGYLRRLVLYGSETGSGFPPYESEPVPQRSFSPEDIHRLKQALKKAGVEKVQDRESILSILWQDPLYFRSPSYPKAIEFRDALIMMLAANAPNLESLSMYPIEFPQNMLKSLLQRASKAAPGSVPYCQNLKEINFHPDDARNQGTTYVEDPYYDRLNVVRKLPAIESVTFKLASWDNNAGLPLPPHCANYSKISFTHSLMQEYDLCRIIESSKTLKSFTFTVDGRKDPEGGITILSVVPLLQSLWFHRHTLEVLDLDMESCTNWQEFYDTNYQLDENEGLDEDEQKFYEEQYADELRDLATHKLEVPPSCISLKDFPKLKSLSLGVHTLCYLARGVGSSRDRFPDGRIRPQSFNLIDHLPPNLESLCVYGRGEGPHGFKSSVLESDLDVDAQLERLSRERDSKSLKILEGIATPIPNGKVVDDWADNNDRTLYWKDPDDNRFDDEERIMLEAEEKYKKIFACMKDSDPYKPMLARYLATLSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W6QI27</accession>
    <name>W6QI27_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Probable transposable element</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S05g000296</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QI27"/>
    <dbReference type="STRING" id="1365484.W6QI27"/>
    <dbReference type="OMA" id="EEMAIFV"/>
    <dbReference type="OrthoDB" id="4368392at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM36463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="51" mass="5785" checksum="7747941B4BF8FAF2" modified="2014-04-16" version="1">MVDALVDHLAEKPGLYVEEMAIFVFDEFNVIPSISSIKRALYRAGWSKKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W6QIC8</accession>
    <name>W6QIC8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Probable transposable element</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PROQFM164_S01g003144</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM164</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:negative regulation of rDNA heterochromatin formation"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:negative regulation of silent mating-type cassette heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053051">
        <property type="entry name" value="HDAC_complex_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47793">
        <property type="entry name" value="HISTONE DEACETYLASE COMPLEX SUBUNIT CTI6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47793:SF1">
        <property type="entry name" value="HISTONE DEACETYLASE COMPLEX SUBUNIT CTI6"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Zinc finger PHD-type" evidence="5">
        <location>
            <begin position="102"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
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            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="604"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="18"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="43"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="204"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="245"/>
            <end position="255"/>
        </location>
    </feature>
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        <location>
            <begin position="269"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="310"/>
            <end position="346"/>
        </location>
    </feature>
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        <location>
            <begin position="353"/>
            <end position="368"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="426"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="455"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="467"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="539"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDM29332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="663" mass="72358" checksum="70736B59A487AE0C" modified="2014-04-16" version="1">MSPRRSSRARTSQPSPALLQQTNSSSSSSNSLTRERSTRSNHKNPSPHESTSHRSQSIDDAEGGSKDPPHTRQRQRAHDDDDDPPREEDEDDLDDDEEEVTRCLCGQQEYPGLPSSRREALGRGTIKLESGQVPTDLSDPLSDDIGSMFIQCDLCKVWQHGGCVGIMDEATSPDEYFCEECRKDLHKIKDEPHGQRSSTYLPVAPEPVPPPPPPPPPPPAPSQTPTPASAPAPTPTPTPTPAVPEVPDVPVAPVVPAVPPSPGPSSRASSRDISRRSRDPKSRTSESAAAHAKRRSTMNSRDAAYDEEELIRRAIEESKAETKSNADETDTHLGKRSRSDSVTNRERAKRPRTTSPSPSAVSRHSNIASHPPSGDEAKPKPAVNGSRRQRATSRGQVEKEPKNDPDEGETEAPEAAKRRKERSNRRKGDESEHETGSPTKTAPPEPEPSQASPNTPTPQEPAPVRPSTRKSGRPPARRGRVGRNQYTKDRDTNGNGDVGYMANSPRRGQSHEVGGDSPRLGYSGVNGAHVNGGESGRPSRPRHMHPHRTTMNEMKRRVAAILEFISRMQVEMAVSSENSSTPTGNGDRAQGLLLKSMVNQIENDMPSARSDGGESGPATTDGGYGESTNHERDFKELSSVEMMDVLTRHLLKWQQEFGKFGER</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W6QIG4</accession>
    <name>W6QIG4_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Apurinic-apyrimidinic endonuclease 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PROQFM164_S05g000048</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM164</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AP endonuclease 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QIG4"/>
    <dbReference type="STRING" id="1365484.W6QIG4"/>
    <dbReference type="OMA" id="DEGCQSH"/>
    <dbReference type="OrthoDB" id="7663182at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003906">
        <property type="term" value="F:DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00019">
        <property type="entry name" value="AP2Ec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.150:FF:000001">
        <property type="entry name" value="Probable endonuclease 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.150">
        <property type="entry name" value="Divalent-metal-dependent TIM barrel enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00152">
        <property type="entry name" value="Nfo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001719">
        <property type="entry name" value="AP_endonuc_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018246">
        <property type="entry name" value="AP_endonuc_F2_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00587">
        <property type="entry name" value="nfo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21445:SF0">
        <property type="entry name" value="APURINIC-APYRIMIDINIC ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21445">
        <property type="entry name" value="ENDONUCLEASE IV ENDODEOXYRIBONUCLEASE IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00518">
        <property type="entry name" value="AP2Ec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="Xylose isomerase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00730">
        <property type="entry name" value="AP_NUCLEASE_F2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00731">
        <property type="entry name" value="AP_NUCLEASE_F2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51432">
        <property type="entry name" value="AP_NUCLEASE_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Xylose isomerase-like TIM barrel" evidence="10">
        <location>
            <begin position="143"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="390"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="458"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="68"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="458"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="489"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDM36215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="513" mass="56246" checksum="43880EFADABF3CC3" modified="2014-04-16" version="1">MCCQESGSPRCEDSESKVSHKRNLSHGTSELSPPRRSKRQKSTTNLKELSSPEASESEAEEFTPTVKNEVDNKPLVDTAKEKKKKAPVKKSNEDAKPKKARKSKKDQELENMPLAPRTKGLRMFVGAHVSAAKGVFNSIYNTENIGGNAFALFLKSQRKWDNPALPDDQRDQFRKLCAEKGYDATKHVLPHGSYLVNLAQSDKVKSKQAYTSFLDDLRRCEALGITLYNFHPGSTNQTPLPEALSRLAEMLVQTITETTTVVPVLETMCGHGNTIGGALSEFRDLLALIPKEHHSRIGICVDTCHSFAAGYDLTSPAGFKSFLAEFDELIGIKFLRALHLNDSKAPRGSKRDLHANIGTGFLGLRAFHNVMNEPRFEGLPMVLETPIDRVPGQNVATGDDAADGSESESGKKKLPKKGPRGPAGAGGAAVPDQGVWAGEIKLLESLIGMDPEGEEFRALEARLSEEGRAEREKHQEQYERKLEADEKKKAKGPGKAKGQKSLMDMMKSGAAKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W6QJ87</accession>
    <name>W6QJ87_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Bromodomain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PROQFM164_S05g000318</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QJ87"/>
    <dbReference type="STRING" id="1365484.W6QJ87"/>
    <dbReference type="OMA" id="KMNIPHY"/>
    <dbReference type="OrthoDB" id="784962at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05500">
        <property type="entry name" value="Bromo_BDF1_2_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05499">
        <property type="entry name" value="Bromo_BDF1_2_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050935">
        <property type="entry name" value="Bromo_chromatin_reader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027353">
        <property type="entry name" value="NET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038336">
        <property type="entry name" value="NET_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22880:SF225">
        <property type="entry name" value="BROMODOMAIN-CONTAINING PROTEIN BET-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22880">
        <property type="entry name" value="FALZ-RELATED BROMODOMAIN-CONTAINING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17035">
        <property type="entry name" value="BET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51525">
        <property type="entry name" value="NET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bromo" evidence="4">
        <location>
            <begin position="287"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="4">
        <location>
            <begin position="480"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="domain" description="NET" evidence="5">
        <location>
            <begin position="658"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="374"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="577"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="621"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="737"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="18"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="34"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="65"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="84"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="96"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="122"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="221"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="249"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="378"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="404"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="429"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="586"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="624"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="648"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="768"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="799"/>
            <end position="813"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDM36485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="813" mass="89254" checksum="570598E3C26E54C1" modified="2014-04-16" version="1">MATPPPEAPPVTKEDKPQLPPSPTGPSAPDYPPTSAQNATVNLKSDGPTDTEVKSPALNGHTPVEPSNTNGTIVATSPPKSPEHQTSPGVDQNKTPSAAGSAPPAEAQPTEDKNVLPQGQVSTTPAPASTAAESAAVSAPQPAAHVSTFPASTDGPSDTPEPMVIDTPQDVSTAVKTDLPHHPTTAPAPPALPPVLTAPQHVDQEMKDGSEAPPSPSKVSRQRDADLSEEPAPKRTKVEGDESVINFQTPGYSSPAAATPGPTRTGGGPGLTKMQHKFILKSLTSLKRMHDARFYKEPVDAIKLNIPQYHTIITQPMDLGTMERKLKNNQYSSPQAVADDFALMVNNTTVFNGADHLVTQEGIKLKATFEKQMTNLPKPEEVEERKPKKHTEKTSAARREPRTSLPSQPKASSPQSQTFALGPEGLPVIRRDSSNPDGRPKRSIHPPKRDLPYSTKPKKKKFQWELRFCQEVLDELHKQKHYSWVMPFYYPVDPVALNIPTYHSVIKKPMDLSTAQSKLKTGQYENAREFENDVRLIFKNCYRFNIPGDPTFVCGQRAEEIFNAKWAQKSDYLEAHEPHPEQNTDSSDEDSDEDAEESEEDDEKLTLLQKQIAEMSRQVEAITNKKKKTPPSSKKVGKKLAKKDSKKISSGKRDKKSKISQPGKTRAITYNEKQIISNGISSLPDKRMQQALQIIQNNVPQLKGTDEAEIELDIDELPNDVLLKLLNFVKKHVPNLMDDEDEDDLPASSVAPPKPKKNKPMSKFEQEAQINMLQSNLSRFQGGAHSPDPVASVERNESSDDESDSSEEESEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>W6QJD8</accession>
    <name>W6QJD8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S01g003509</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QJD8"/>
    <dbReference type="OrthoDB" id="5401170at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM29697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="73" mass="8172" checksum="5DFD14FD01AF94ED" modified="2014-04-16" version="1">MRIYLQVPNLKTDFRTPHRRAEQAIASPTHLEIESLKKLQLMGSTVAPKLLAVHQDKQSDTGSVPGGYINYLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>W6QJE4</accession>
    <name>W6QJE4_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">P-type Cu(+) transporter</fullName>
            <ecNumber evidence="3">7.2.2.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Cu(2+)-ATPase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">PROQFM164_S05g000761</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="18">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 18">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.8" evidence="3"/>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QJE4"/>
    <dbReference type="STRING" id="1365484.W6QJE4"/>
    <dbReference type="OMA" id="HWMLPAW"/>
    <dbReference type="OrthoDB" id="432719at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043682">
        <property type="term" value="F:P-type divalent copper transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140581">
        <property type="term" value="F:P-type monovalent copper transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055070">
        <property type="term" value="P:copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030003">
        <property type="term" value="P:intracellular monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="CDD" id="cd02094">
        <property type="entry name" value="P-type_ATPase_Cu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.100:FF:000001">
        <property type="entry name" value="ATPase copper transporting beta"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000002">
        <property type="entry name" value="Copper-transporting ATPase 1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017969">
        <property type="entry name" value="Heavy-metal-associated_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006122">
        <property type="entry name" value="HMA_Cu_ion-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027256">
        <property type="entry name" value="P-typ_ATPase_IB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01525">
        <property type="entry name" value="ATPase-IB_hvy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00003">
        <property type="entry name" value="copper ion binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43520">
        <property type="entry name" value="ATP7, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43520:SF8">
        <property type="entry name" value="P-TYPE CU(+) TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00942">
        <property type="entry name" value="CUATPASEI"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="HMA, heavy metal-associated domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01229">
        <property type="entry name" value="COF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01047">
        <property type="entry name" value="HMA_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0186">Copper</keyword>
    <keyword evidence="9" id="KW-0187">Copper transport</keyword>
    <keyword evidence="15" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="16 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="12" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="369"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="403"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="444"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="475"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="657"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="698"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1051"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1080"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="20">
        <location>
            <begin position="17"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="20">
        <location>
            <begin position="105"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="20">
        <location>
            <begin position="196"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="20">
        <location>
            <begin position="277"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="869"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="875"/>
            <end position="888"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00080126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU362081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="CDM36928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="1189" mass="125226" checksum="A28C7906F62CD431" modified="2014-04-16" version="1">MLSTNPHAGGAGRPALATTTLKIDGMTCGACTSAVEGAFQGVDGAHDVSVSLIMGRATVQHDPSVLPPAKVAEMIEDRGFDATVLSTEEQRNPDSTSSSPAMRLSVTTLAIEGMTCGACTSAVESGLNDVSGVNSVDVSLLSERAVVEHDAGIITPEQIAELIEDRGFGARVLDTALVGSKEPPAPAGSEEKSGLLVTTIAIGGMTCGACTSSVQGALGSVDGVIQFNISLLAERAVVVHDPTILPASKIPELVEDAGFDASIVSSEAQASISKKTQQINLSLHGLRDGVSATALEDNILQHSGVHSASIKMATSRMAISFDPSTIGIRSIVEIIEAAGYNALIVDSDDTNAQLQSLSKTKEIQEWRRSFIIAASFAVPVFLISMILPMYLPGIDFGRFALVPGLYLGDVVCLALTIPVQFGIGRRFYVTSFKSLKHRSPTMDVLVMLGTSAAFFYSCFTMIMSLCSADHGRPSTVFDTSTMLITFITLGRWLENRAKGQTSAALSRLMCLTPSMTTIYEDPIAAEKLAERWTSKPVHGAPEQPTLGDDMTVNQKCIPTELIQVGDIVILHPGDKVSADGVIIRGESYVDESMISGEALPIHKKKGSQVIAGTVNGTNSIDFKVIRAGKDTQLSQIVKLVQDAQTSRAPIQRMADIVAGYFVPTIIGLGLITFFGWMFLSHVLAHPPTIFEMAGSGGRVMVCLKLCISVIVFACPCALGLSTPTAVMVGTGVGAEHGILVKGGAVLEAATKVTHVVFDKTGTLTTGRMSVAHTRIEPQWAMNDWRRQLWWLVVGLAETGSEHPIGRAIVSAAITESGHAGEDGLPGSTGDVDNYVGKGVSAVVEPTSSGQRIRHHVLLGNARFLRSQDVPVPADADPDSAEPVEDPEADIPKPGVTGAGTTRIHVAIDNRYAGTISLRDTVKETAVAAVAALHRMGITTSMVTGDTLSTAISIATAVGIPTATIHASVSPSEKRSIVSALQEKGERVAMVGDGINDSPALATASVGIALASGTDVAVEAADIVLMRPDDLLSVPASLSLSRSVFRRIKLNLIWACMYNVIGLPFAMGLFLPFTGFMLPPMAAGGAMALSSVSVVVSSLLLKFWTRPSWMEVERLEKEVQSGAISAAGVAPRKGSWWPSTTIFSNSPRSLRRRVGNVFSSLWSLVTGKGPMPADRGDDGYVPLQTVESPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W6QJX8</accession>
    <name>W6QJX8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S05g000124</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QJX8"/>
    <dbReference type="OMA" id="YFYKGMV"/>
    <dbReference type="OrthoDB" id="4955540at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM36291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="144" mass="15982" checksum="E887B63E3312FBA2" modified="2014-04-16" version="1">MSTINMVKYYFYRGMLPENQQRLRDLIALAYQTARDRKLYPKAILIRSNEHSSTSQGGIHKPDPLGWHVTLCFKDDVQLASNTHVASHGYVKGKGDLTFLQATHSGVKPDSHLKSSGKPVWPSEMELDVAPEIGYGHFPSAGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W6QK41</accession>
    <name>W6QK41_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Major facilitator superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PROQFM164_S06g000149</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792020">
        <property type="protein sequence ID" value="CDM37188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QK41"/>
    <dbReference type="OMA" id="WVLASHQ"/>
    <dbReference type="OrthoDB" id="6499973at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF284">
        <property type="entry name" value="EG:103B4.3 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="25"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="100"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="130"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="248"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="311"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="342"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="382"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="414"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="4">
        <location>
            <begin position="26"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDM37188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="456" mass="49071" checksum="0B932717CC156154" modified="2014-04-16" version="1">MERSLTPMLVDGENPANSPTRLHSIIIIIASTTLVFTGCGINFAFGVFQELYDSMSKEPNTPFTGATPAQIDLIGTLSIALMTIGAPFATAWTKQYPPRYVIWASGIIHSSALLFASFSQHLWQFILTQGILLGMATCLTYMPSVTVAPTWFTLHRGLAMGIILAGTGIGGVAWPLAFRYLIESLGFRNTLRVTAGISFALICGSGTFIRWPASQITRIQAENAASSRSSTFFRLPLVDWRVVQSRKFVAHALGAALQSAAYYTPVFFFASFARTLGYSQATSANFIAISNAANALGKIVIGHAANRMGRLNTLVLTTLISAVSVLALWLPSCLSATQSTGSTLFIAFTIFYGVFASAYVALFPTSLVELFGVQNFVSVNGLLYMVRGLATLVGTPVAGALIRGNHEKSVGPRSYENTSIMVGVLLVVATLAVVWARLEATLTLDSTVGRRMKWLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W6QKD1</accession>
    <name>W6QKD1_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Protein CCC1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">CCC1</name>
        <name evidence="7" type="ORF">PROQFM164_S05g000718</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CCC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QKD1"/>
    <dbReference type="STRING" id="1365484.W6QKD1"/>
    <dbReference type="OMA" id="QMCCVGG"/>
    <dbReference type="OrthoDB" id="73465at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005384">
        <property type="term" value="F:manganese ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030026">
        <property type="term" value="P:intracellular manganese ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02435">
        <property type="entry name" value="CCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008217">
        <property type="entry name" value="Ccc1_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31851">
        <property type="entry name" value="FE(2+)/MN(2+) TRANSPORTER PCL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01988">
        <property type="entry name" value="VIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="211"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="241"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="272"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM36885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="307" mass="33053" checksum="1A9BEF55A7692D5C" modified="2014-04-16" version="1">MALLFIKRKLFPTKDADRIQSGKRLLARIESDDTIRADSEQDLESQNGRSYDTFGRCNSPDESAITTNSNCSTRERINPRIISDAILGLSDGLTVPFALSAGLSALGNTKVVVLGGLAELAAGAISMGLGGYVGAKSEAESYQTIVRETQELIQTDSEETRAMVRETFSPYGLSDSAVADITRDLHASQDRLLEFLLAFHHREIAPDCNQAWTSAITLALGYFIGGFIPLIPYFIVSQITIALYWSIGVMAITLLVFGYVKTCVVRGWSGRANVWAAIWGGMQMCCVGGVAAGAAIGLVHLIDMGST</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W6QM18</accession>
    <name>W6QM18_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Alpha-mannosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PROQFM164_S02g000762</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM164</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MNN1/MNT family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QM18"/>
    <dbReference type="STRING" id="1365484.W6QM18"/>
    <dbReference type="OMA" id="YMKDATE"/>
    <dbReference type="OrthoDB" id="4484309at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046354">
        <property type="term" value="P:mannan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022751">
        <property type="entry name" value="Alpha_mannosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31646">
        <property type="entry name" value="ALPHA-1,2-MANNOSYLTRANSFERASE MNN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31646:SF1">
        <property type="entry name" value="ALPHA-1,2-MANNOSYLTRANSFERASE MNN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11051">
        <property type="entry name" value="Mannosyl_trans3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="69"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="69"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDM30612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="496" mass="55712" checksum="87F1C804271DE4CC" modified="2014-04-16" version="1">MGALRPGRAKALVLAMLALILVCTVYFYRSPITASSNVPLVPNTAFEVPLTERQKDFWKVLRPIIERHKPSCPSPEKRGDVEAQHFDPTKDVPRPDLTGLSDEDVRKMEEAHAAFIEDIKQSDKELKPIHTPGKRGLVSTAGSTYLPVFVSSLRMLRRAGSTLPVELYMKDATEHEKEICNEVLPKLDARCLVLADVVGKNIIEHYQLKIFAVLFSSFEEIVWMDADCFPLGKPEDLLDSEPFKTNGLVTWPDFWASSASPLYYKISRQQAPSMAARQSSETGVFLVSKKTHSLALLLAAYYNFYGPSHYFRLLSQGAPGEGDKETFIQAASAVGAPFYTVSERVQAVGHANADGLSGSAMAQSDPREDFALIQQDKWRVKDESVAPAPHVFFIHANYPKFNPGDRIFGMGWETTPTLKKDGSDGRAWLAPPETIKRFGYDVEKAYWEEIKWVSCNLETAFKTWENKVDLCKRVEEYWGHVFAEPHDDDPKFTLDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W6QME4</accession>
    <name>W6QME4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Endonuclease/exonuclease/phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PROQFM164_S06g000562</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM164</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
            <location evidence="3">PML body</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792020">
        <property type="protein sequence ID" value="CDM37600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QME4"/>
    <dbReference type="OMA" id="PWIRENW"/>
    <dbReference type="OrthoDB" id="9975959at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070260">
        <property type="term" value="F:5'-tyrosyl-DNA phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051547">
        <property type="entry name" value="TDP2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15822">
        <property type="entry name" value="TRAF AND TNF RECEPTOR-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15822:SF4">
        <property type="entry name" value="TYROSYL-DNA PHOSPHODIESTERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="12" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="12" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="11">
        <location>
            <begin position="48"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDM37600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="312" mass="34996" checksum="918568AACE52706D" modified="2014-04-16" version="1">MPVRIPQYFSCFSPAARRWVPVASRPIQSPGVQSSAQGNTPRSHFNIVSWNIDYSSSYPTRRCLDLINHVFKYGVPDILCLQEVRSEVRASLLGNREIRQAFLTTDAATDLEYKRFITMTLLSKERFAYSLDSKEMGGSNDEGKFIVGPVFREHLPSAAGRDGLCVDLIPPCAPDTFLRIINAHLESCDGFSYRAAQLKQLSSVLHEPGCSGGLIVGDFNSVTDDDRLLIEENKLKDAWLTLHGDTKPDAPTWSVGRRRDPRYEPSRLDKVAMVGLEAEMMELMHPLCINATKPSDQIEWSDHSGLRCKFCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W6QMV9</accession>
    <name>W6QMV9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tropomyosin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cdc8</name>
        <name evidence="3" type="ORF">PROQFM164_S02g001102</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QMV9"/>
    <dbReference type="STRING" id="1365484.W6QMV9"/>
    <dbReference type="OMA" id="EQWETKY"/>
    <dbReference type="OrthoDB" id="128924at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.340:FF:000001">
        <property type="entry name" value="Tropomyosin alpha-1 chain isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000533">
        <property type="entry name" value="Tropomyosin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19269">
        <property type="entry name" value="TROPOMYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00261">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="1"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM30952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="161" mass="18699" checksum="F9A8A959CBB09887" modified="2014-04-16" version="1">MDKIKERMVALRAEADEAHELVDELKAKVKTLEQENLSKEQEITSLNHRNQLLEEEVEKTEAALKEAKDAASQSLQHDTQNEALQRRVQLLEEEAEENDKTLRETNEKLRQTDIKAGHYERKVQALEDQHAKLEQRYEDAIKEHSTVKKELDDLASQMADI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>W6QMY1</accession>
    <name>W6QMY1_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Mitochondrial carrier domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PROQFM164_S02g001142</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QMY1"/>
    <dbReference type="STRING" id="1365484.W6QMY1"/>
    <dbReference type="OMA" id="TYNSGMI"/>
    <dbReference type="OrthoDB" id="427452at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990547">
        <property type="term" value="P:mitochondrial phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000024">
        <property type="entry name" value="MIR1p Mitochondrial phosphate carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044677">
        <property type="entry name" value="SLC25A3/Pic2/Mir1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45671:SF12">
        <property type="entry name" value="MITOCHONDRIAL PHOSPHATE CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45671">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25 (MITOCHONDRIAL CARRIER PHOSPHATE CARRIER), MEMBER 3, LIKE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="20"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="118"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="216"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDM30992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="306" mass="32164" checksum="767AE78D618DBD56" modified="2014-04-16" version="1">MAATPVSTPQLTNSKPEGINLYARFALAGALGCSVTHGAFTPVDVVKTRIQLDPLTYNRGMIGSFRQVIRNEGISVLATGFGPTFAGYFMQGAFKFGGYEFFQQKSIDVLGAEKAKQNNTAVYVVSAGCAEFFASVALCPLEATRIRLVSTPGFANGLIDGFGKIVKNEGVGALYSGFGPILFKQVPYTITKFVAFEKISEAILSQFDKSQMSAGASTAVNLGSGLLSGFAAAIVSQPADTMLSKINKTKGLPGESTVSRLIKIAGELGLRGSFAGLPTRLFMVGGLTAGQFAIYGDIKKFLGATK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>W6QMZ2</accession>
    <name>W6QMZ2_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dbl homology (DH) domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S07g000108</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792021">
        <property type="protein sequence ID" value="CDM37760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QMZ2"/>
    <dbReference type="STRING" id="1365484.W6QMZ2"/>
    <dbReference type="OMA" id="WTHIQDD"/>
    <dbReference type="OrthoDB" id="8059989at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051092">
        <property type="entry name" value="FYVE_RhoGEF_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001331">
        <property type="entry name" value="GDS_CDC24_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12673">
        <property type="entry name" value="FACIOGENITAL DYSPLASIA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12673:SF159">
        <property type="entry name" value="LD03170P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00741">
        <property type="entry name" value="DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="2">
        <location>
            <begin position="145"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="595"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="680"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="66"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="596"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="691"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="718"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="747"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="767"/>
            <end position="787"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM37760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="806" mass="90311" checksum="C1114F3E7248A0F5" modified="2014-04-16" version="1">MADQDEMNIEKQALLNDESEEKFESGGGVTLADKSTSRPFKKWIDSFRGRKHESPTCQRRYVEGWSDSSSHGSQGHQSSASDSSHLGTVKTTTASIGSQSLIRSRTTIQSATNQSTLSGVRHSGDSSRPSLSQNTDEAAETRATRRRHILQELVETESDYVLGLKALIGILTIFDTRREIYDNIQEILGIHERFLNQLQRASPMSAPQAQQAGASELTSRGITKRIGSLDLGSLKGLQQRSLRTRSLKASVNQRLMALTAEPTEGLEVARELEKLALSFPAYDQFCSNYELLTQDVALLRRSIANWTIYDQGIEALSKSVASTERRRQEDHKSMTLNDLLIKPIQRLCKYPLVLQDLLRSTPVSDCPSSHDGIQQVLDSIRLLVTRVNLSAGNPINKDRIDKTIVLQDKVDISESHALQSIYKDLGPLVMCGVLHVTYQTMDTTNGEFMVCVLFQRYLLFAKGIDDLRRLEAVACVYLDSLKIDTLQNGRGLCSYGCIFSWKLLFENKDENYEFVLSASSAVEEKQWNTEILKMSAALVEVAQPRTWEPRKHSFLTLQLLPLDHVQYTVSSMARRSSMDSMAISRKFRVQHVVIKKTNDPRHTEETASQAEGELERPKTSTDRSALTLTARRIDRIRLERLISDIYTGDLLPLPGMVLGRGDLFRRGSIMRRLSLRPGFTRRSSSVGAFHSRAESTDMHSDEENERMDKEAAGSSEIGEDKEVECEVPRTPTTPRPSKTFLFKGSPKNPTASVSSPRSDKRRSQDGSSESSPSSKKWSSPQKWSSPKNLFSALAPKKLKKTRSDAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W6QNY3</accession>
    <name>W6QNY3_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S09g000041</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792023">
        <property type="protein sequence ID" value="CDM38125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QNY3"/>
    <dbReference type="STRING" id="1365484.W6QNY3"/>
    <dbReference type="OMA" id="TSWETFV"/>
    <dbReference type="OrthoDB" id="10039566at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022185">
        <property type="entry name" value="DUF3712"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046368">
        <property type="entry name" value="Tag1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35895:SF2">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35895">
        <property type="entry name" value="CHROMOSOME 16, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12505">
        <property type="entry name" value="DUF3712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM38125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="426" mass="46367" checksum="12D89C2044B1B420" modified="2014-04-16" version="1">MVLGMGKYINRGLLNPKSDESAKVQNARSPVSSTSKKIKFRRHCRRFWCFYLIANVIVLAIFLPVFFLVAIPAVAQLVVNKSDLRLVNAEVMHPTADTVRMTLEAKVNLKLALGVRLDPVVFYAFVRSAGHENAYAGIEIPGQTIKGNYSLKVTDQLTPILNMTSWETFVSQAVSQKETALSLHGVTVGYLGVLKNHIILDKDVVMPTLNKFEGFSIANSTFLLPAEDDGTNLVANITLPNPSVLSFEVGTITLDLKSGNTDLVIGNATVKDVTLRPGNNTFPLRGVIDIGAMIGNLSEVLSSQGPAIRTGALSLTAVTRSIVSNGTLIPYYTKVLGSLPLVANVSIGDVLRNSLTHLGSSETLSDFDDKRRRGPVQLGGPVGYGVAYNQVASLKHNRHVQKMFEDEDPERRDAIIESLARYYASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>W6QPV6</accession>
    <name>W6QPV6_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">DNA-directed RNA polymerase subunit beta</fullName>
            <ecNumber evidence="14">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="primary">RPB2</name>
        <name evidence="23" type="ORF">PROQFM164_S04g001000</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25 26">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the RNA polymerase beta chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="14"/>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM36119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QPV6"/>
    <dbReference type="STRING" id="1365484.W6QPV6"/>
    <dbReference type="OMA" id="CYDRNDS"/>
    <dbReference type="OrthoDB" id="10248617at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032549">
        <property type="term" value="F:ribonucleoside binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00653">
        <property type="entry name" value="RNA_pol_B_RPB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.270.10:FF:000006">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.150:FF:000002">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1100.10:FF:000005">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1100.10:FF:000022">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1110.10:FF:000003">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1800.10:FF:000002">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1100.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.270.10">
        <property type="entry name" value="DNA-directed RNA polymerase, subunit 2, domain 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1800.10">
        <property type="entry name" value="RNA polymerase alpha subunit dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1110.10">
        <property type="entry name" value="RNA polymerase Rpb2, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015712">
        <property type="entry name" value="DNA-dir_RNA_pol_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007120">
        <property type="entry name" value="DNA-dir_RNAP_su2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037033">
        <property type="entry name" value="DNA-dir_RNAP_su2_hyb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007121">
        <property type="entry name" value="RNA_pol_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007644">
        <property type="entry name" value="RNA_pol_bsu_protrusion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007642">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037034">
        <property type="entry name" value="RNA_pol_Rpb2_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007645">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007646">
        <property type="entry name" value="RNA_pol_Rpb2_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007647">
        <property type="entry name" value="RNA_pol_Rpb2_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007641">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014724">
        <property type="entry name" value="RNA_pol_RPB2_OB-fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007175">
        <property type="entry name" value="PRK09606.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20856">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04563">
        <property type="entry name" value="RNA_pol_Rpb2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04561">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04565">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04566">
        <property type="entry name" value="RNA_pol_Rpb2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04567">
        <property type="entry name" value="RNA_pol_Rpb2_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00562">
        <property type="entry name" value="RNA_pol_Rpb2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04560">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01166">
        <property type="entry name" value="RNA_POL_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 14 23" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 14" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 14" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RNA polymerase beta subunit protrusion" evidence="19">
        <location>
            <begin position="37"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="18">
        <location>
            <begin position="285"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="20">
        <location>
            <begin position="500"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="21">
        <location>
            <begin position="599"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="22">
        <location>
            <begin position="703"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed RNA polymerase subunit 2 hybrid-binding" evidence="16">
        <location>
            <begin position="781"/>
            <end position="1153"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="17">
        <location>
            <begin position="1155"/>
            <end position="1247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="138"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU363031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF04560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF04561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF04563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF04565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF04566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF04567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="CDM36119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="1255" mass="141597" checksum="7EF614DB1A72A489" modified="2014-04-16" version="1">MVEYEETYEEDFYDEADEGITSEDCWTVISSFFDSKGLVSQQLDSFDEFISSTMQELVEEQGQVVLDQTLPPSEDEVEPIVVRRYELKFGTVMLSRPSVTEGDGATTIMLPQEARLRNLTYASPLYLGVTKKIMEGREKMGKPNDDDDNEGESDPKTQGTYLDWETKQLPQEQMKEETVFIGKMPIMLKSKYCILKDLNEASLYAWNECPYDSGGYFVINGSEKVLIAQERSAGNIVQVFKKAPPSPTPYIAEIRSAVEKGSRMLSSLTLKLFAKGDSAKGGFGPTIRSTLPYVKADIPIVVVFRALGVVSDEDILNHICYDRNDTPMLEMLKPCIEEGFVIQDREVALDFIAKRGSSQTNLNHDRRVRYARDIMQKELLPHISQSEGSETRKAFFLGYMVHRLLQCALGRRDVDDRDHFGKKRLDLAGPLLASLFRTLFTRVTKDLQRYVQRCVETNREIYLNIGIKASTLTGGLKYALATGNWGEQKKAASAKAGVSQVLSRYTFSSSLSHLRRTNTPIGRDGKIAKPRQLHNTHWGLVCPAETPEGQACGLVKNLALMCYITVGTPAEPIVDFMIQRNMEVLEEFEPQVTPNATKVFVNGVWVGIHRDPSHLVTTMQNLRRRNMISHEVSLIRDIREREFKIFTDTGRVCRPLFVIDNDPKSENSGGLVLNKEHIRKLEADKDLPPDLGPEERREQYFGWDGLVRSGAVEYVDAEEEETIMIVMTPEDLEISRQLQAGYALPEDETSDPNKRVRSILSQRAHTWTHCEIHPSMILGVCASIIPFPDHNQSPRNTYQSAMGKQAMGVFLTNFSQRMETMANILYYPQKPLATTRSMEFLRFRELPAGQNAIVAIATYSGYNQEDSVIMNQSSIDRGLFRSLFYRTYADTEKMVGLQVVERFEKPMRIDTLGMRKGTYDKLDEDGIVAPGVRVSGEDIIIGKTAPLAADAEELGQRTKAHTKIDVSTPLRSTENGIVDQVLISTGNDDLKFVKVRMRTTKIPQIGDKFASRHGQKGTIGITYRQEDMPFTREGVVPDLIINPHAIPSRMTIAHLIECQLSKVSALRGFEGDATPFTDVTVDSVSRLLREHGYQSRGFEVMFNGHTGRKMVAQVFLGPTYYQRLRHMVDDKIHARARGPTQILTRQPVEGRARDGGLRFGEMERDCMIAHGASAFLKERLFDVSDPFRVHICDDCGLMTPVAKLKKGLFECRLCNNKHRISQVHIPYAAKLLFQELASMNIAARMFTDRSGVSVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W6QPW8</accession>
    <name>W6QPW8_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">chitin deacetylase</fullName>
            <ecNumber evidence="4">3.5.1.41</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PROQFM164_S02g001762</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + n H2O = chitosan + n acetate</text>
            <dbReference type="Rhea" id="RHEA:10464"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9597"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:57704"/>
            <dbReference type="EC" id="3.5.1.41"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:10465"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="3.5.1.41" evidence="4"/>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QPW8"/>
    <dbReference type="STRING" id="1365484.W6QPW8"/>
    <dbReference type="OMA" id="PNNYFRP"/>
    <dbReference type="OrthoDB" id="407355at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004099">
        <property type="term" value="F:chitin deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd10958">
        <property type="entry name" value="CE4_NodB_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050248">
        <property type="entry name" value="Polysacc_deacetylase_ArnD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10587:SF137">
        <property type="entry name" value="4-DEOXY-4-FORMAMIDO-L-ARABINOSE-PHOSPHOUNDECAPRENOL DEFORMYLASE ARND-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10587">
        <property type="entry name" value="GLYCOSYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="3" id="KW-0170">Cobalt</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="9"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="domain" description="NodB homology" evidence="7">
        <location>
            <begin position="53"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM31612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="247" mass="27890" checksum="6F26C6CF5CBF93D5" modified="2014-04-16" version="1">MNPPQKPNMLRAILATLFLLVPFYYIYKPPSLLIRYCQRRWPDVLFRVDTDKKVVALTIDDAPSIHTPAILRLLESYNAAATFFVIGSQIPGHESVLADLVRAGNELANHAMYDEPSRALSDDVLADQMRTVHAGIQEAYVAAGKTEPENWLFRPGSGVFSSRMRTLVKELGYRLVLGDVYPHDPQVPFWKLNASHILSMVKPGSIIVCHDRREWTVPMLQKVLPELDRRGYRVVTVSGLLKEIGVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W6QPY7</accession>
    <name>W6QPY7_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Oligopeptide transporter OPT superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PROQFM164_S02g001777</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QPY7"/>
    <dbReference type="OMA" id="THFNTSM"/>
    <dbReference type="OrthoDB" id="9986677at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004648">
        <property type="entry name" value="Oligpept_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00727">
        <property type="entry name" value="ISP4_OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22601">
        <property type="entry name" value="ISP4 LIKE PROTEIN"/>
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        <property type="entry name" value="OPT"/>
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    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
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        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="162"/>
            <end position="187"/>
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    <feature type="transmembrane region" description="Helical" evidence="9">
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            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
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            <begin position="225"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
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            <end position="324"/>
        </location>
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            <end position="400"/>
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            <end position="461"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="467"/>
            <end position="489"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022856"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CDM31627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="556" mass="63218" checksum="9AF9C00D7639EE7A" modified="2014-04-16" version="1">MEANKDTDINLLERNIREKEEVQDENNTDSDSQTEILRAAGIGIAKDDPTEPVLTLRMWVIGIAFCVIVSGLNTLYTLRAPSLTISGSVVLLLAYPLGKLWEKIVPNWTVPLGRLAFELNPGPFNTKEHVLIFIMSNLSIYVRLGADVLTEQQMFYGYKAGWGFQILITFSTFLIGFCLAGLFRAIVVVPQELIWPGVLGVTALTTTLHHVNQQKVQVTYNTWKMSRYAFFGMAFSISFCWYWFPDFIFPALSYFSFPCWIKPESKVVNQIFGMNSGMGLLPLTFDWSQISYVGSPLLIPSWAVFNVFVSLVFWIWIVAVALYYSNVWNTGYLPFQSSQVFDNTGNIYKVKKIVNAASGYKLDVKKYLAYSPVYMPVTYALNMFGLSFATLSALLVWVVLEKRHVMADAAKRVPRLVLESFPGRSREYSEDERGDPDVPLWWYLVACVLALFMSMFAVEWWNVELRWYGVLLACTVALIFYPALALVYATSNLKINIDIFCRIVAGFVFEGKVLANIWFFDIGYITTIKGLYFAQDMKLAYYCHASPFLPTIVESC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W6QQ49</accession>
    <name>W6QQ49_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S28g000001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792042">
        <property type="protein sequence ID" value="CDM38591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QQ49"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM38591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="46" mass="5332" checksum="284359FC43DB631E" modified="2014-04-16" version="1">MDLESLAASVQPPSPMPKERIAQLNHRRRALESNSWSQQMIQTLWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W6QQG3</accession>
    <name>W6QQG3_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DNA-directed RNA polymerase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">rpa12</name>
        <name evidence="13" type="ORF">PROQFM164_S05g000137</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QQG3"/>
    <dbReference type="STRING" id="1365484.W6QQG3"/>
    <dbReference type="OMA" id="EMQYHTL"/>
    <dbReference type="OrthoDB" id="10056816at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006363">
        <property type="term" value="P:termination of RNA polymerase I transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10507">
        <property type="entry name" value="Zn-ribbon_RPA12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.10:FF:000024">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019761">
        <property type="entry name" value="DNA-dir_RNA_pol-M_15_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012164">
        <property type="entry name" value="Rpa12/Rpb9/Rpc10/TFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034004">
        <property type="entry name" value="Zn_ribbon_RPA12_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001222">
        <property type="entry name" value="Znf_TFIIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239:SF14">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01096">
        <property type="entry name" value="Zn_ribbon_TFIIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005586">
        <property type="entry name" value="RNApol_RpoM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00440">
        <property type="entry name" value="ZnF_C2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01030">
        <property type="entry name" value="RNA_POL_M_15KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51133">
        <property type="entry name" value="ZF_TFIIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8 13" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 9" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIS-type" evidence="12">
        <location>
            <begin position="79"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="10">
        <location>
            <begin position="10"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR005586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR005586-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR005586-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDM36304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="121" mass="13181" checksum="DB051386E5D8310B" modified="2014-04-16" version="1">MSAIGSLIFCTDCGNLLRESTGNADAILHCDVCGTRNKDTIPQTTVSQSKPSAFPSALRAKLSAVQVLSAEDRKTEAIIDRTCNECGRKQMFYTTVQLRSADEGSTVFYRCVCGFKETTNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W6QRB4</accession>
    <name>W6QRB4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PROQFM164_S14g000015</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792028">
        <property type="protein sequence ID" value="CDM38516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QRB4"/>
    <dbReference type="STRING" id="1365484.W6QRB4"/>
    <dbReference type="OMA" id="RICVHEM"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF12">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="446"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM38516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="531" mass="59710" checksum="F224EE1A9A7529A8" modified="2014-04-16" version="1">MMIASPLNVILSVGIGAMVLYAMVLLARRRVHGPLPPGPPGKPILGNIYDLPPPGAQDWMHWLKFKDRYGQISSISVMGQTIVILNHHQIAMELLGKRSAIYSSRPNLVFASQMVGWEHILAMQTYSDRLRAYRKAMQPYLGSETAVSQYNELQEVESHRFLLRVLKDPKNLIQHISTEAGAVILKIAYGYTIEPDKMDPLVHIAKMALEQFSVAGTPGAWLVDVFPALRYIPSWFPGAGFKRTAQVWKQNLQHVADKPYAFVRQRMESGNYDPSYLSNLFEAGGYPPNGTEEEMIAKWTAASLYTGGADTTVSSVQTFFLAMTLYPEVQRKAQEEIDRILGGARLPTVVDRASLPYVDAVVKETLRWHPVAPMGIPHMSVKDDMYEGHLIPEGSLVLANIWAFAHDTEVYHEPMKFKPERFLNVDGREPELDPRTFVFGFGRRICPGRILADYALYLIISRSLAVFDVRKEVRNGHEVHVEPEFRPGVISHPLSWEFNIKPRSASCEALIRSVEETNPWRGSDAAALDTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W6QRD7</accession>
    <name>W6QRD7_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Natural resistance-associated macrophage protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PROQFM164_S05g000457</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QRD7"/>
    <dbReference type="STRING" id="1365484.W6QRD7"/>
    <dbReference type="OMA" id="STYLVWT"/>
    <dbReference type="OrthoDB" id="409173at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015086">
        <property type="term" value="F:cadmium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005384">
        <property type="term" value="F:manganese ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030026">
        <property type="term" value="P:intracellular manganese ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034755">
        <property type="term" value="P:iron ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00221">
        <property type="entry name" value="NRAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001046">
        <property type="entry name" value="NRAMP_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01197">
        <property type="entry name" value="nramp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF037982">
        <property type="entry name" value="Nramp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11706:SF101">
        <property type="entry name" value="MANGANESE TRANSPORTER SMF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11706">
        <property type="entry name" value="SOLUTE CARRIER PROTEIN FAMILY 11 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01566">
        <property type="entry name" value="Nramp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00447">
        <property type="entry name" value="NATRESASSCMP"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="194"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="260"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="306"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="376"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="420"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="467"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="497"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="550"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="85"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM36624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="576" mass="61486" checksum="268AD5C3C4B9860D" modified="2014-04-16" version="1">MNCPSRTDDTLENPSWNQSPPPFSPDTTTRNDFNGLANSRVHRRHASSANAAGDDPLCIDDRPISQQDQDPGKEKVPSGEVTAADSGGDSPPGSSGSPRHSFYTSLKSSPLHCAQTLVKFGRFIGPGFLIAVAYIDPGNYATDVAAGADFKYALLFIVLLSNLFAILLQSLCIKLGSVTGLNLAENCREHLPKWLVIFLYILAEAAIIATDIAEVVGSAIALNLLLKIPLVAGCAITLVDVLFILIFYRPNGKMVGLRLFEFFVMALVLGVVVCFCIQLSLVKNQSVGEVFRGYVPSSAIVQSEGLYQSCGILGATVMPHSLFLGSGVVQSRLKEFDVNSGYVETSMPLGSADGEVKYRPSIHAIRGCMKYSIIELALSLFTFALFVNSAILIVAGAALYDLPGGGSADLFGIHDLLSKSIAPAAGLVFALALLLSGISAGIVCTIAGQMVSEGMLNWTIRPWLRRLITRSVSIIPSIIIAGAVGKEGLDRTLTASQVALSVILPFVSAPLIWFTCLNRYMTVRTEEASERDGEVDVVTVPMRNNLFTSVVAVLVWIVIVVMNVALLVLVGLGKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W6QRF5</accession>
    <name>W6QRF5_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">NADPH--hemoprotein reductase</fullName>
            <ecNumber evidence="8">1.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PROQFM164_S02g002278</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>2 oxidized [cytochrome P450] + NADPH = 2 reduced [cytochrome P450] + NADP(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24040"/>
            <dbReference type="Rhea" id="RHEA-COMP:14627"/>
            <dbReference type="Rhea" id="RHEA-COMP:14628"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:55376"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="EC" id="1.6.2.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="1.6.2.4" evidence="8"/>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QRF5"/>
    <dbReference type="STRING" id="1365484.W6QRF5"/>
    <dbReference type="OMA" id="PLQGNME"/>
    <dbReference type="OrthoDB" id="1856718at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003958">
        <property type="term" value="F:NADPH-hemoprotein reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.990.10">
        <property type="entry name" value="NADPH-cytochrome p450 Reductase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003097">
        <property type="entry name" value="CysJ-like_FAD-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001094">
        <property type="entry name" value="Flavdoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023173">
        <property type="entry name" value="NADPH_Cyt_P450_Rdtase_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384:SF17">
        <property type="entry name" value="NADPH--CYTOCHROME P450 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00667">
        <property type="entry name" value="FAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00369">
        <property type="entry name" value="FLAVODOXIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0288">FMN</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="10">
        <location>
            <begin position="8"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="11">
        <location>
            <begin position="210"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDM32127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="658" mass="72983" checksum="5C0D4761B4AF7435" modified="2014-04-16" version="1">MSPANVRAVVFWASQSGTAEALASRYASELSTAFPLGAMTANLADYDHKHMPDVPSQALLVFILSTFGDGDPPDNGTALLESLHQLRKQSANLNNVRYLIFGLGNSNYTHFNKYALDIDGMLKGMGATRLGRVGLGNDREGATEEDFVAWKNESIQQVARTLHLRPVEREYSPRIQIRPWRGGNCDTRHGVSPTVYYGEPQYAPPTADRSTTVVLPVIQAKQLMLSKEAIGESESSRECVHLEFSLEDHPSITYETGDYLCIWPVNPEQEVSALLKVLGVWNTRKNVIDIVPADDTSSSNIRIPTPTTMESLFRYFLDICGPVSRELVRGIAELTSDGDFKRRLEALTRDRDAFYEEVTLKKLTLAAVLQAATTVRDENGSAINVAVSYVLENLKKLQPRSYSISSSAAVDPRIAAITALAVSGPPRPPRETSSCPSHRFRGLASNYLLQLQKEYNRSYSRSQQPTNYYYSTAGPRGLLEGGKVFAYIRRSNFKLPPDPSTPIIMIGSGTGVSPFRAFVQERMKLKNQGCEVGKTVLLVGHRAPDQDYYYQDLWQEASKALGKRFEVYTAFSRVDTQPRQYVQDLLATKSDLVLDILAANQPKGGVMYICGSSLMANGVKKSLVEICSQGHLQSVAETAEKWVGELSRLRRLQEDSWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>W6QRX3</accession>
    <name>W6QRX3_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PROQFM164_S02g002428</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3"/>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QRX3"/>
    <dbReference type="STRING" id="1365484.W6QRX3"/>
    <dbReference type="OMA" id="IQDKWAA"/>
    <dbReference type="OrthoDB" id="5857104at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000014">
        <property type="entry name" value="SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10799">
        <property type="entry name" value="SNF2/RAD54 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="586"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="13">
        <location>
            <begin position="940"/>
            <end position="1090"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="85"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="171"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="310"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="525"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="32"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="139"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="316"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="357"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDM32277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="1124" mass="124719" checksum="B1E5DCE8D70E4FEB" modified="2014-04-16" version="1">MEEAINSTPPRDIKTIPSTPPGEDYETIATLPATTPSQRLTQPTQLLEHPYSRHNNTVIQVAASSPLGPAFSPPRRVQGGLLSSLIAPSGTQFRPPASGPTKRTPRFDLDDGPTYRGGSSDEECHLQSPDIKPSMFAKPPRDSEKEKIMESPVRPDAGSMDRFREITASAMYDPKNAGTATKRTADQMSPPAPKGVATKKARQDAPSRAPPSGVPDIPLHEINDFRLRVKVERILKVMPHMTVLACMDAMLKAKGNYDGALQILAKMDSENGPVVIASSDDELSASPATGPVPMAKQNIKARGTIQDKWAAMKQPKGQESDDEGKPRRRLVRGPKSDGSRAISPSRAITIKDDSPPKKKLGRLQKGRKAPSPDRSESPEAMMSDSDDSNVQVQESTAGGLDSKVLKFFNTCRVQDLADIASIPEATAEIIISNRPYETLDEVRVVSAPVAQAVKPKGKRGGKAPKPIGDKIVDKCIDMWTGYLAIDALVGEVEELGKPVAEEMKKWGVDTFGKKGDLEITNLAPAKSEHDSGIATPTTERQSSESDEESGKLVVSKRKSRFISQPSIMADDLVMKDYQVVGVNWLALLFEKNLSCILADDMGLGKTCQVIGFLAHLYEKGIKGPHLIVVPSSTIENWLREFQKFCPVLNVMPYYAGLNERALIREEIEERRDEINVVITTYTIAKAKLDAKFLRDMDFTVCVYDEGHMLKNHQSQLYEKLIRIRARFRLLLTGTPLQNNLQELASLLGFILPSVFREHKDDLHAVFSNKAKTTDESHATLLSQQRIERAKSMMKPFILRRKKHQVIDLPAKHSHVGWCQMKPSQVKIYDHEKAEVRQLVADRLAGKKTGSKSANILMKLRQAAIHPLLARRHYTNEILQKMAKACLKEDKWSLSDPNIIYEELMPYNDFECHHMCVENPNSLGKFKLKNDEWMDSGKVEHLKELLTRFIANGDRTLIFSQFTMVMDILEHVLETLKIEFVRLDGRTNVEDRQSILDAFHERTEIPVFLLSTKAGGAGINLACANRVVIFDSSFNPQEDVQAENRAHRVGQTREVEIYRLVTKSTIEEQIHALGQTKLALDQAVAGDDEAGAKKSEEVGMKAVEEMMIAELEAEAAAEAAAAAEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W6QS28</accession>
    <name>W6QS28_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GDPGTP exchange factor Sec2p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PROQFM164_S02g002468</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QS28"/>
    <dbReference type="STRING" id="1365484.W6QS28"/>
    <dbReference type="OMA" id="CCEFTGY"/>
    <dbReference type="OrthoDB" id="1748564at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070319">
        <property type="term" value="C:Golgi to plasma membrane transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21044">
        <property type="entry name" value="Rab11BD_RAB3IP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040351">
        <property type="entry name" value="RAB3IL/RAB3IP/Sec2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009449">
        <property type="entry name" value="Sec2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14430">
        <property type="entry name" value="RABIN3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14430:SF0">
        <property type="entry name" value="SEC2P DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25555">
        <property type="entry name" value="RAB3A-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06428">
        <property type="entry name" value="Sec2p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144284">
        <property type="entry name" value="Sec2 N-terminal region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GDP/GTP exchange factor Sec2 N-terminal" evidence="4">
        <location>
            <begin position="115"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="18"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="258"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="357"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="540"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="579"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="639"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="122"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="186"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="39"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="266"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="647"/>
            <end position="664"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDM32317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="691" mass="76293" checksum="0874DE42BDA4DE09" modified="2014-04-16" version="1">MADLIAFQTSHHSFFSPSKMISRNSHKRSLSSEHRSLSPDRTVTKAKSTTNLSEIAAANAAQNSGYYESSFSTLQDPRLLIGSEVSHSTSSSHHPDLSNEVAALSVKLIQAINNQTNLDDNLVATRQELELAQGKIQALEYQNEKYRRDIDNQIYIKKVDSDREISQLRDALAEETTLRLAAEKGRKNIEQEVETLTAALFEEANKMVASAKIDREAVEKKNEQLRSQVKDTELLLASHQDQLAELKSVMQTMNLHKDDMEGRPANSPSSPDESQAQGSNQDTEFEPVPILIGNPEEFTPGPSSSFPHLLRMVCRADLQAYEDFRDLLVLSRSSKPPSRAASGSYGGLNVMGLASFASGGSPSSTSSPTKGFSYSPNGSISSTTGSGFSLKETRFYKRVLMEDIEPTLRLDLAPGISWLTRRTVLSGICEGSLVVEPMPTSAQKFEFPCSVCGERRPGTSNARTHRFRTSDSETAQRYSLCILCLERVRSCCEFTGYLRLILDGHLRAGDTEEEKEIWDETIRLRERMFWSRVGGGIIPLGNRPSEPEVPASTEPNTGVQDDADQYLYPVDVTYLEPRTEKVPVADPIAPETPVRASTTDHITPPDLSRPQSPMYDRDDAASLDDLQRKRLSIDSAASVYEEASTDVDANTTAPAPNEPSIIQSRETDTDIAKPNGLSDSLPRLITSDQHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W6QSG4</accession>
    <name>W6QSG4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S06g000014</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792020">
        <property type="protein sequence ID" value="CDM37054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QSG4"/>
    <dbReference type="STRING" id="1365484.W6QSG4"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM37054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="69" mass="7431" checksum="BD0E3D1DC89C0232" modified="2014-04-16" version="1">MSLGKKVTLNTGHQIPQLGFGTWQSAPGLVGEAVYEALKAGYRHLVCTSTRTSVRSPRASSVLIKMFPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W6QT59</accession>
    <name>W6QT59_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Zinc finger C2H2-type/integrase DNA-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PROQFM164_S02g002863</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QT59"/>
    <dbReference type="STRING" id="1365484.W6QT59"/>
    <dbReference type="OrthoDB" id="3437960at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003:SF22">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G11480)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR PROTEIN YY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="96"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM32712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="189" mass="21268" checksum="11C0328A07410134" modified="2014-04-16" version="1">MPAIPLLFTLIDGRHIRFQKKDYGVSVNDSSYGSCQQAQIQVFLGSLRQGAISRAILEYTLTNAPIIVPKKNCNKKFIQRSALTVHIRTHTGEKPHVCGYTGCQKAFADSSSRARHRRIHTSDRSFICEEPMCEISTNEARIPRSLSSNPPRTSTIRALLWPDLFSYQKLECTICASTVAKFRVSDPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W6QTD6</accession>
    <name>W6QTD6_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S02g002923</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QTD6"/>
    <dbReference type="OMA" id="ATSSDMC"/>
    <dbReference type="OrthoDB" id="4490227at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055560">
        <property type="entry name" value="DUF7136"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23584">
        <property type="entry name" value="DUF7136"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004879832" evidence="2">
        <location>
            <begin position="25"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7136" evidence="3">
        <location>
            <begin position="28"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM32772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="281" mass="29900" checksum="9F6D34F82F40EA64" modified="2014-04-16" version="1">MYTFNNRLYLGSLLALQACTKVIGASATSGVLEVDLVFPRNETYAPSAQMPVVFAIQNPHLVAPLNMKVSYIITPPRNYSNISEPALFNMNSTSLFSSDPYFLYNNTDFVNLEGTWELTWFVEYGRCTGSSGDIMFYPSNSTIDSIIFTTKSGAAKPDLIAAGKKDTCATGIAAWNVTGAMDVEGADWGGYDTCAVVSKRSPWATVDPCAAKFDSAIASNISAALNATAGDKVSADEKNSKDENDSKEKDPAADNAGAVHLPGGGVTLLTAIFAGLTYIFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W6QVE2</accession>
    <name>W6QVE2_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="7">1-aminocyclopropane-1-carboxylate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PROQFM164_S09g000015</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792023">
        <property type="protein sequence ID" value="CDM38099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QVE2"/>
    <dbReference type="STRING" id="1365484.W6QVE2"/>
    <dbReference type="OMA" id="YPAFYRD"/>
    <dbReference type="OrthoDB" id="1077582at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050478">
        <property type="entry name" value="Ethylene_sulfur-biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43795:SF32">
        <property type="entry name" value="AMINOTRANSFERASE GLII-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43795">
        <property type="entry name" value="BIFUNCTIONAL ASPARTATE AMINOTRANSFERASE AND GLUTAMATE/ASPARTATE-PREPHENATE AMINOTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00753">
        <property type="entry name" value="ACCSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="6">
        <location>
            <begin position="63"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM38099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="418" mass="45536" checksum="092C0F24A8CFBF4E" modified="2014-04-16" version="1">MASRISDRCKKRNATIIPSLIGQHDAVLSGDTTTIDLSTAENWATKTKLLQGLEGVFSGLSENDLAYSSGIGGCPTTRQLIADLINDRFQPSIPVENSHVVLAAGGSFALTALIEQICDPGDGILIATPYWAGLDISISVHAHATVVPVHIPLIDFFSTNSISHYESALEISSSPIKAVLVCNPHNPLGQCYPLETLDALLEFCKRHELHYISDEVYALSAHQPFPGGFHPFVSALQRGDRETRAQVHVIYSLSKDFGCNGIRIGALITQFNDAVRLSSALSVHSQVSSLSTVLASKTILQPTNIDTAISYGAQSLMGSYKVIQSFLENAGMEYIPVAFGMFVFSRLGRVSNFDAERKLLRCLKSRGVSVSSGSSYHFQEPGWFRICYAVPSDQLEEGLRRIGLGIQDFHQTFNVDEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W6QW68</accession>
    <name>W6QW68_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type DNA-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PROQFM164_S11g000092</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792025">
        <property type="protein sequence ID" value="CDM38389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QW68"/>
    <dbReference type="STRING" id="1365484.W6QW68"/>
    <dbReference type="OMA" id="CPLVGSM"/>
    <dbReference type="OrthoDB" id="1924260at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052400">
        <property type="entry name" value="Zn2-C6_fungal_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47657">
        <property type="entry name" value="STEROL REGULATORY ELEMENT-BINDING PROTEIN ECM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47657:SF12">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="19"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDM38389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="590" mass="65111" checksum="90C18EF828681372" modified="2014-04-16" version="1">MVGPGGGPPRKSHTKSRNGCKTCKRRHIRCDETFPQCRNCTKHNCRCDYQDTVASQAGSPPAPRQGPDLLMSPEIETQIDNWHRTGVPPYPELLQCPRAGWSGLSRTDLRLIHYIIGASIDLHRRGLSGCTVWAQKMPNFLAIALGSEFVMSSILSFSAFNLAFLTRDPETKQLAFSRRLTALQGLQTALGSFSKENCDAILAASVLLSWQATDHQNWASLQHGISSVLESMHPYWKQESDIAQSIETQRRMSTDLSMPGVYKAPDEDMIHLDQTIQALRMTQKRVSHNPEHFERLGDLIKFTQKFRNDFPNQTTAQVFESVQPIRRWFFWLPASMLGRGESDISALPILAQFFAVGISLDGCFPEMGGAYLGALLVGPIEEIYRIIATHHAADPFNPDLRLPLELMDLPRGIVARHRSRCNLPWSPRSSVDPYSPGPPSPFHHNLHEYSLVASSSSPASASTSYAAYTPPLHSPPAVTIANSTFPVQDGYASATPIPHSLYPPSPHSLYPPSPQLIDSQDPNLGLSDMGHSNAHHPSIPHPAAYTPPYGDGLCASLPRTDGTLGLNMEVYPQPHPFEMPGLAAPTSLWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2024-10-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>W6QWZ9</accession>
    <name>W6QWZ9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S03</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S03g000781</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QWZ9"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM34057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="86" mass="9834" checksum="7BCB0F85FD4DBC20" modified="2014-04-16" version="1">MHLRCQSSATYVLPQLVPRPIVFTFGLWGASFPDYSAWLCLGSGPPVHKIRDKICRTWPPYTSMEYYAPYGNMPRSTEYCAELLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W6QZK9</accession>
    <name>W6QZK9_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">thioredoxin-dependent peroxiredoxin</fullName>
            <ecNumber evidence="1">1.11.1.24</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Thioredoxin peroxidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PROQFM164_S03g001729</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a hydroperoxide + [thioredoxin]-dithiol = an alcohol + [thioredoxin]-disulfide + H2O</text>
            <dbReference type="Rhea" id="RHEA:62620"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:35924"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.11.1.24"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the peroxiredoxin family. BCP/PrxQ subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.24" evidence="1"/>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM35002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QZK9"/>
    <dbReference type="STRING" id="1365484.W6QZK9"/>
    <dbReference type="OMA" id="TWYRGGW"/>
    <dbReference type="OrthoDB" id="338622at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008379">
        <property type="term" value="F:thioredoxin peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02970">
        <property type="entry name" value="PRX_like2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050924">
        <property type="entry name" value="Peroxiredoxin_BCP/PrxQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42801:SF7">
        <property type="entry name" value="SLL1159 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42801">
        <property type="entry name" value="THIOREDOXIN-DEPENDENT PEROXIDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="6" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="10">
        <location>
            <begin position="43"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDM35002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="214" mass="24291" checksum="FC009510FBD251B8" modified="2014-04-16" version="1">MALNKELSSTYNQFLETAPKEVSSIITDAVRDFKNSYDPARAIQPGDAFPQFHLSDATGNEVSLNDLLVEGPILISFYRGEWCPFCNLELRALQSHMDEFHQKGVTLVAVSPELPDHSLTTSEKLLLKFPVLSDVGNQLAKKLGLLFPQPESMRTVFDKFGVDWNQRYGNDNLELPVPATFLVDKKGIVRNSFVNPQYRHRLEPEIAIEWIDRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2024-10-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>W6R0V7</accession>
    <name>W6R0V7_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S04</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S04g000348</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6R0V7"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM35467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="65" mass="7199" checksum="331A3C01538C4150" modified="2014-04-16" version="1">MISLETASPAVIAAVMAWEPRGLFFDQAKDNAVNETETQGVGFGARVWLYNMVIAHSTNSFYFLN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2021-02-10" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W6R1D9</accession>
    <name>AC891_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Acyl-CoA ligase 891, peroxisomal</fullName>
            <shortName evidence="1">ACL891</shortName>
            <ecNumber evidence="1">6.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="ORF">PROQFM164_S04g000523</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Acyl-CoA ligase involved in the biosynthesis of mycophenolic acid (MPA), the first isolated antibiotic natural product in the world obtained from a culture of Penicillium brevicompactum in 1893 (By similarity). The peroxisomal acyl-CoA ligase 891 converts the intermediate MFDHMP-3C into MFDHMP-3C-CoA which impairs its diffusion from the peroxisome (By similarity). The first step of the pathway is the synthesis of 5-methylorsellinic acid (5MOA) by the cytosolic polyketide synthase mpaC. 5MOA is then converted to the phthalide compound 5,7-dihydroxy-4,6-dimethylphthalide (DHMP) by the endoplasmic reticulum-bound cytochrome P450 monooxygenase mpaDE. MpaDE first catalyzes hydroxylation of 5-MOA to 4,6-dihydroxy-2-(hydroxymethyl)-3-methylbenzoic acid (DHMB). MpaDE then acts as a lactone synthase that catalyzes the ring closure to convert DHMB into DHMP. The next step is the prenylation of DHMP by the Golgi apparatus-associated prenyltransferase mpaA to yield farnesyl-DHMP (FDHMP). The ER-bound oxygenase mpaB then mediates the oxidative cleavage the C19-C20 double bond in FDHMP to yield FDHMP-3C via a mycophenolic aldehyde intermediate. The O-methyltransferase mpaG catalyzes the methylation of FDHMP-3C to yield MFDHMP-3C. After the cytosolic methylation of FDHMP-3C, MFDHMP-3C enters into peroxisomes probably via free diffusion due to its low molecular weight. Upon a peroxisomal CoA ligation reaction, catalyzed by a beta-oxidation component enzyme acyl-CoA ligase ACL891, MFDHMP-3C-CoA would then be restricted to peroxisomes for the following beta-oxidation pathway steps. The peroxisomal beta-oxidation machinery than converts MFDHMP-3C-CoA into MPA_CoA, via a beta-oxidation chain-shortening process. Finally mpaH acts as a peroxisomal acyl-CoA hydrolase with high substrate specificity toward MPA-CoA to release the final product MPA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4,8-dimethyldeca-4,8-dienoate + ATP + CoA = (4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4,8-dimethyldeca-4,8-dienoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:66700"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:167390"/>
            <dbReference type="ChEBI" id="CHEBI:167446"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:66701"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Secondary metabolite biosynthesis; terpenoid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.-" evidence="1"/>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6R1D9"/>
    <dbReference type="SMR" id="W6R1D9"/>
    <dbReference type="STRING" id="1365484.W6R1D9"/>
    <dbReference type="OMA" id="KCPIVEH"/>
    <dbReference type="OrthoDB" id="1700726at2759"/>
    <dbReference type="UniPathway" id="UPA00213"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140722">
        <property type="term" value="P:mycophenolic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272:SF33">
        <property type="entry name" value="AMP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0576">Peroxisome</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000451897" description="Acyl-CoA ligase 891, peroxisomal">
        <location>
            <begin position="1"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="region of interest" description="Fatty acid-binding" evidence="2">
        <location>
            <begin position="525"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Peroxisome targeting signal" evidence="1">
        <location>
            <begin position="705"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="259"/>
            <end position="270"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P9WEY3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000305" key="3"/>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM35642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="707" mass="77898" checksum="D07B7E46DE4083DA" modified="2014-04-16" version="1">MFFSQPTHLAKAEELKQAPPKGVAYSVALPGTEQPGRSPVYRAWNAQKELLTTLDPEVTTAHDIFESTAIRHPKNDCLGWRPYNSTTKSFDPYQWLTYETVQKRRAAFGAGIVELHHKHDCHRPGQYGVGLWSQNRPEWQITDLACVSQSLYSVSIYDVLSEDATEYIINHSELSCVVTSLPHIASLIKLKPSLPTLKIIISLDPLDGGEQAGHSKRAIFESMAAGLGLAIYTIDQVEELGLASKRGYNPPSASDIVTINYTSGTTGPPKGVVLTHGNAVAATSCGLITISQARGDTSASYLPLAHIYARLAEHTAFWGAARIGYFHGNIAELVDDLKLLKPTGFMSVPRLYSRFGSAIRAATVEQPGFKGALSRHIIAAKTANMKNPDPSKATVRHALYDRIWAKKVTAALGLERARYMVSGSAPLDPTLHNFLRVATGTDVLQGYGLTESYASATAQPVYDLTAGNCGSLAPCVEACLVSLPDMEYSVDDKPFPRGELLLRGNNMFREYYKNEEETRSAITEDGWFRTGDVCTIDEKGRFIIIDRRKNVLKLAQGEYISPERLEGVVLSELGYIAQAYVHGDSLQTFLVGIFGVAPDLFAPYASKVLGRTIAPTDLEAVKESLNDDKVRRAVLRDLERVAKKHKFAGYERIRNVSLKVEPFTVENNLLTPTLKLKRPPTVKVYRSLLDQLYEQAVEEQSAPKAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>W6R4H0</accession>
    <name>W6R4H0_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Probable E3 ubiquitin ligase complex SCF subunit sconB</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Sulfur controller B</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Sulfur metabolite repression control protein B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PROQFM164_S05g000550</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the SCF(sconB) E3 ubiquitin ligase complex involved in the regulation of sulfur metabolite repression, probably by mediating the inactivation or degradation of the metR transcription factor.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the SCF(sconB) E3 ubiquitin ligase complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat MET30/SCONB/SCON-2 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6R4H0"/>
    <dbReference type="STRING" id="1365484.W6R4H0"/>
    <dbReference type="OMA" id="HSKGIAC"/>
    <dbReference type="OrthoDB" id="19711at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050995">
        <property type="entry name" value="WD-F-box_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14604:SF4">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14604">
        <property type="entry name" value="WD40 REPEAT PF20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 9" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="F-box" evidence="11">
        <location>
            <begin position="107"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="317"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="358"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="403"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="491"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="531"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="173"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="187"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDM36717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="821" mass="91350" checksum="538CEE60B924E5EA" modified="2014-04-16" version="1">MEGEPLPDAPDAADARISPTLQLQTTTVSEFPALSLSPSFKLDEGYSDDTRSQADKDLGSDNVMALPSWLLAQSETGRAELAYSLLRSLPTSSIAAVVDRLNPIFHIDPCVRLPPEVTWQVFTYLDARTLLNASLASRSWRERILDSGLWKFKYIHEGWGMDTGAIRAFEQEHSEAMSPQTRKSRLRHSEPDLGEPKHKKRVPSTWLNSRSDENQKPTVFGPALPVADSEGDHHMTDDDDQTTPSFADDPELIMPTSTSQSFSPLYPPLRSHLLIRDTDGSAKVNYFHIYKQRRRLEANWHQGRYTNFQLPDPSHPEEAHRECVYAIQFEGRWLVSGSRDKTLRVWNLDTKRLWHPPLVGHIKSVLCLQFDPRPEEDIIISGSSDKSVIIWKFSTGEKIHQIEDAHLDSVLNLKFDHRYLVTCSKDRTVKVWNRRALLPNSKDYPHICHGSGATYPTWIIDLNTIPPSVLEAGIAHDQYKVLEPYTLLMTVEGHGAAVNAMQIHGDDIVTASGDRVIKVWNIRTGACSKSLLGHEKGIACVEFDSRRIISGSNDNSVRIYDHATGAEVACLRAHSNLVRTLQAGFGDAPGADETLREEAIACETAFFAAQEAGLDVDMGHREQRRNGYQPNTAGSRDPRDIPALGAKIPPGGGGSSWARIVSGSYDESILIWHKDRNNKWTTDHQLRHSDAIANSARANLSQVARNTVAAQAQAQQLQAAQALATLGQNPNINPHAGRANPQFLPPLVINALPLAPLPAHHHHHHGHQRRPQGSSTAARVFKLQFDARKLICASVDPRIVGWDFACDDQDIIEASPFFKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>W6R7T8</accession>
    <name>W6R7T8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Sorting nexin, Snx5/Snx6 types</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PROQFM164_S07g000266</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Golgi apparatus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the sorting nexin family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792021">
        <property type="protein sequence ID" value="CDM37917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6R7T8"/>
    <dbReference type="STRING" id="1365484.W6R7T8"/>
    <dbReference type="OMA" id="LWETFLM"/>
    <dbReference type="OrthoDB" id="271164at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030904">
        <property type="term" value="C:retromer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045053">
        <property type="term" value="P:protein retention in Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07627">
        <property type="entry name" value="BAR_Vps5p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06861">
        <property type="entry name" value="PX_Vps5p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1520.10:FF:000013">
        <property type="entry name" value="Putative Sorting nexin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000022">
        <property type="entry name" value="Sorting nexin 3 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035803">
        <property type="entry name" value="BAR_Vps5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037868">
        <property type="entry name" value="PX_Vps5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015404">
        <property type="entry name" value="Vps5_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10555:SF170">
        <property type="entry name" value="FI18122P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10555">
        <property type="entry name" value="SORTING NEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09325">
        <property type="entry name" value="Vps5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PX" evidence="13">
        <location>
            <begin position="164"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="541"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="452"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="23"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="79"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDM37917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="568" mass="62614" checksum="98AAD1C5D74D16BE" modified="2014-04-16" version="1">MDLDSGDSPWGDEPSRFKHSDGPKPGAEEGAAATPASDSSPAVQTPGRRGPRGTRKINAQATKLESIDDSVDPLGPLGEAPVEDTPTPTDEAPAPPQKEPFAGRGARPLSSPSQASGVEAADSANLEEESAVFRGPPPVQPPVQADGPKRQTQPSMSVEQAAKPTFHIYVGDPHKVGDLTSSHIVYQVSTKTTSKAYRQPEFTVSRRYRDFLWLYNSLHSNNPGVVVAPPPEKQAVGRFDTNFVESRRAALERMLNKIAGHPILQHDGDLKIFLESEAFTVDVKNKENREPDIGPSKGMLSSFGISVGGGTKFVEHDDWFHDRKVYLDALENQLKALLKSMDTVVIQRKGLSEAASDFSSSLHALSAVELSPALSYPLEGLSELQLRIRELYDRQAQQDVLTLGITIDEYIRLIGSVKLAFTQRQKAFHTWHAAESDLQKRKNNQDKLLRQGKTQQDRLNQVNADVADAERKVHQTRLLFEDMGRLMRNELQRFEKEKVEDFKSGVETFLESAVEAQKELIELWETFLLRLDAGEEGLPYYVPPEVSDAPAPAEPTDESGLLAAEDDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W6PQS9</accession>
    <name>W6PQS9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sporulation/nuclear morphology, Spo7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S01g000362</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PQS9"/>
    <dbReference type="STRING" id="1365484.W6PQS9"/>
    <dbReference type="OMA" id="ENWDEYR"/>
    <dbReference type="OrthoDB" id="5599171at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071595">
        <property type="term" value="C:Nem1-Spo7 phosphatase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006998">
        <property type="term" value="P:nuclear envelope organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005605">
        <property type="entry name" value="Spo7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28249">
        <property type="entry name" value="SPORULATION-SPECIFIC PROTEIN SPO7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28249:SF1">
        <property type="entry name" value="SPORULATION-SPECIFIC PROTEIN SPO7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03907">
        <property type="entry name" value="Spo7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="128"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="326"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="363"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="394"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM26553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="461" mass="52007" checksum="44F14B4DFDE675E7" modified="2014-04-16" version="1">MASPLDQVVKGAPTPGASAPSTPEPLNSSRSSQAHRSDSSPPRPSTPDPLAHLPSSPPQIYLNLLILETSLRAQYLALRERRRQNTFFLLLLAAWLAHFAYALFLRPREDGRGVGGSVYWVVEMGEKVALLGGVVTALLIWGTGQWERGIRWPRRWLAVSNRGLRVMNTKIIIIRGPFWQELLSYISFLFPFSAPFLPSPNGNYHFVEQSPSDKRAGGGRQHYQQYYNGTDSESGMVEEDLSPGGDYIRLLLLPKSFSPEFRENWDDYRTDFWEKENERRAQLRLKLRERERHLAQTEGGWLGRLGLGWRASQRRRLVAGTLHRSLEQESKHRPGHGHHPITKLGQEQRGPSRRNTRSESHSRTSSRSTTPVDTSFEDRPPSRSSPSSRPRRGSTASGQDASPQQQKRKGSTLRRGLSPLTQAQIREGIRTPSFSSDDSVLPMGMLEKDKEEAIPNSVPEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W6PRB5</accession>
    <name>W6PRB5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PROQFM164_S01g000075</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FM164</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PRB5"/>
    <dbReference type="STRING" id="1365484.W6PRB5"/>
    <dbReference type="OMA" id="YHAFNAY"/>
    <dbReference type="OrthoDB" id="3945418at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11062">
        <property type="entry name" value="CYP58-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000069">
        <property type="entry name" value="Cytochrome P450, putative (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF157">
        <property type="entry name" value="N-ACETYLTRYPTOPHAN 6-HYDROXYLASE IVOC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12 13" id="KW-0349">Heme</keyword>
    <keyword evidence="9 12 13" id="KW-0408">Iron</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 13" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="8 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="12">
        <location>
            <position position="452"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CDM26266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="521" mass="60037" checksum="BD43FB0461B832DB" modified="2014-04-16" version="1">MDWWNAIVAQPILALGVLAMTYGVWLATYRLWFSPLAHFPGPKLAALTMWYEFYYDSFLGGQYTFRIAEMHRKYGPIVRISPFELHIDDPEYYEILYSRDKPRNKSLHLTGMFGAPASAFGSVDHRHHRIRRQPMNPFFSQQRIRQLEPMLRKMIDKLRKGMRNWKERQTPLHVYHAFNAYTTDVVVEYSMGESFHYLDDPDFTPQWSKTIEAIVEVGVQFKQFRWVFGLFELFPRWLVVSINPHIGPVIDQKLESLRLAESIIASQTAGANLTDDKVSVPKGTLFHALLDSKLPPEEKAPGRLSQEVFTVISAGGETTAKNLTTLTFHLLNNPDKLQRLRDELNRLDPNGTATLVEYEAMPYLTSVMLEGLRITNAVATRLQRSSPNQVMTYKDWIIPPGTPVGMTSIFMHHNEDIFPNSQSFIPERWMDPEQRKSLEKYLVAFSKGSRQCIGIPLARAEILLAIATIFREFEMELYETTVDDVRIVRDMFNGHPRKGSRGVRVVIKEWNGHTGQKANSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W6PSA7</accession>
    <name>W6PSA7_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Myb-like DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S01g000450</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PSA7"/>
    <dbReference type="OMA" id="CRMRFIR"/>
    <dbReference type="OrthoDB" id="4365092at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054505">
        <property type="entry name" value="Myb_DNA-bind_8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22980">
        <property type="entry name" value="Myb_DNA-bind_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb-like DNA-binding" evidence="2">
        <location>
            <begin position="44"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM26641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="117" mass="12628" checksum="60B8D5C255C3A0CB" modified="2014-04-16" version="1">MAPVTDTTSKANGPALPKAKLRIKLNVKPPAKAETEVEALKASDEEFLLTLLDTVKVDHQAAANTLGINKAACRMRFIRLQQKYGFKKKGPKGTPRRKKGAAMVTPANEADVAEGED</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>W6PTB2</accession>
    <name>W6PTB2_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Homeodomain-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PROQFM164_S01g000929</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PTB2"/>
    <dbReference type="STRING" id="1365484.W6PTB2"/>
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    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050891">
        <property type="term" value="P:multicellular organismal-level water homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901002">
        <property type="term" value="P:positive regulation of response to salt stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902584">
        <property type="term" value="P:positive regulation of response to water deprivation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902806">
        <property type="term" value="P:regulation of cell cycle G1/S phase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032875">
        <property type="term" value="P:regulation of DNA endoreduplication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000037">
        <property type="term" value="P:regulation of stomatal complex patterning"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033993">
        <property type="term" value="P:response to lipid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Transcription factor MYB124"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050560">
        <property type="entry name" value="MYB_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45614:SF25">
        <property type="entry name" value="MYB PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45614">
        <property type="entry name" value="MYB PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="HTH myb-type" evidence="6">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="5">
        <location>
            <begin position="2"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="5">
        <location>
            <begin position="54"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="6">
        <location>
            <begin position="58"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM27120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="315" mass="35912" checksum="594A9CEC4836B472" modified="2014-04-16" version="1">MPASHRRGPWVPEEDQLLTQLVCEQGPNNWVRISQHMHYRSPKQCRERFHQNLKPSLNRDPISPDEGLMIERMVNEMGKRWAEIARRLGNRSDNAVKNWWNGSMNRKKRGLSTPTTSRTYSGRIEAPYTRASAMSPSRSRFSSSSRPSWTESIESAISEQYSHSRRESMASSTRHLSPIYTLPSINRPIETPLTSPAFSEASHSTSCEPPSMVSDHNSVCSSSPRTFPSPQLLPLPVDLRSQYEMRRPSVHVVEDSPSYPARSLESLSEIASTQRWIGHQPTLASWHQPIDLPKSWISRSEPTRDTRMGLDNLLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W6PTD7</accession>
    <name>W6PTD7_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WD40/YVTN repeat-like-containing domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g000954</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PTD7"/>
    <dbReference type="OrthoDB" id="4336147at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="43"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM27145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="107" mass="11813" checksum="519E970A3B95FBD4" modified="2014-04-16" version="1">MSDVAPQTSFDTISCVKVEKNTIIAGTQDWYHLCAVLCLKLHGNYLVSGGHDGVARVWKIETGQCKDVLRSHERMRMQLSLLAHIGPTAQNQRSGGGCETLKNLQVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2024-10-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>W6PU06</accession>
    <name>W6PU06_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g001154</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PU06"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004881583" evidence="1">
        <location>
            <begin position="23"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM27345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="66" mass="7642" checksum="381398591F07D990" modified="2014-04-16" version="1">MFSWIPGLHLAWMILYVPYVFEQGLIVWDEHVARVTCEVDSSVWVWQEVFRGGLAERPLAGHLSRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W6PUE8</accession>
    <name>W6PUE8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Bifunctional polymyxin resistance protein, ArnA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S01g001192</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PUE8"/>
    <dbReference type="SMR" id="W6PUE8"/>
    <dbReference type="STRING" id="1365484.W6PUE8"/>
    <dbReference type="OMA" id="DECIRIK"/>
    <dbReference type="OrthoDB" id="2735536at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF562">
        <property type="entry name" value="ALDEHYDE REDUCTASE II (AFU_ORTHOLOGUE AFUA_1G11360)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="3">
        <location>
            <begin position="15"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM27381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="336" mass="36698" checksum="2EC57CBDAA60369A" modified="2014-04-16" version="1">MTQAQNYVIPPGSKVLVTGANGYIASHIVKALLDLGYLVRGTVRTPMPWLAEYFERQCGLGRFELIVVSDFQQPDAFDESVKGVSGVIHVAQGLPSSTAAETVKSATAYTVNGVINLFKAASTQRTIQRVVLTSSIVAAGYPTGKGFKLDADSWDESLEQASKDGTTVPIYRACKIEGERQAWKWVEKNQPHFELNSVLPWLTLGKILHPNIGGSTMGYVSGLLRGDTTPFKFLPLPWFVDVEDTARLHAIALLNPSVRSERLFATAAPFTWGDVIEILKRIQPNNARIPAAPIQEEPTLGDVVPAARAEKLLRETFGQLGWTPLEVSLESGIARE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W6PUH5</accession>
    <name>W6PUH5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S01g001222</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PUH5"/>
    <dbReference type="OMA" id="SIYVWET"/>
    <dbReference type="OrthoDB" id="405906at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056120">
        <property type="entry name" value="DUF7703"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37013:SF7">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37013">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_1G05950)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24802">
        <property type="entry name" value="DUF7703"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="27"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="84"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="121"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="165"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="204"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7703" evidence="3">
        <location>
            <begin position="25"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="260"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="310"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM27411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="323" mass="36227" checksum="267F6BE41568A098" modified="2014-04-16" version="1">MATNDARSVEDYLIPGNGPSDLARTGVFAAFAALAWYNSIELVILCFFSFRRWKGIYFWSLLISSGCIIPYTLGYVLLFFRTGVTPWLCVTLVQLGWYGMITGQSVVLWSRLHLVLQNRRLLRGVLWMICIDAVIFHIPTTVLLYGTVAQPASHWARAYNIMERVQLVGFCVQELIISSIYVWETIKLLHLRPEGRPHGILNQLLVINILILLLDISVVVIEYVGYYAIQVMFKPVAYSIKLKLEYAILGKLIAVARGGGSDSQEMHSSTREITESSSFPSNGDRPANRETPMRVRREYSPSWFGGGSSGHSTSSLSGVLQNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W6PUP1</accession>
    <name>W6PUP1_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S01g001749</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PUP1"/>
    <dbReference type="STRING" id="1365484.W6PUP1"/>
    <dbReference type="OrthoDB" id="4424523at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM27938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="107" mass="12247" checksum="88C8303E290D60B6" modified="2014-04-16" version="1">MDELRDNLGTYPDWGFVIYRTTYSADSDTLFPDAIRFIEACFKQEFFQETKEYPPNEPNEIWAKQRSTILQNPAQFNGASLEAIRAYLRPGWTLKACVTVGPNGECA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>W6PVM3</accession>
    <name>W6PVM3_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Probable mRNA-splicing protein ubp10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">ubp10</name>
        <name evidence="14" type="ORF">PROQFM164_S01g001627</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PVM3"/>
    <dbReference type="STRING" id="1365484.W6PVM3"/>
    <dbReference type="OMA" id="QLRRFKC"/>
    <dbReference type="OrthoDB" id="10263353at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02669">
        <property type="entry name" value="Peptidase_C19M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000068">
        <property type="entry name" value="U4/U6.U5 tri-snRNP-associated protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050185">
        <property type="entry name" value="Ub_carboxyl-term_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033809">
        <property type="entry name" value="USP39"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001607">
        <property type="entry name" value="Znf_UBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646:SF16">
        <property type="entry name" value="U4_U6.U5 TRI-SNRNP-ASSOCIATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02148">
        <property type="entry name" value="zf-UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00290">
        <property type="entry name" value="ZnF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50271">
        <property type="entry name" value="ZF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBP-type" evidence="13">
        <location>
            <begin position="101"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="12">
        <location>
            <begin position="223"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="23"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="60"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDM27816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="608" mass="67475" checksum="7C1457422DBFBC7E" modified="2014-04-16" version="1">MSKRHAELPLEQDSSGSPVLKRARVEEGNDPDSRNGAVPAYRTSGEELTQDDLNGVDIEGAAEIEREELEEGENPLGLSDIDEDAPALSAPKRQSAPMEGYGDLYLDTINREILDFDFEKLCSVTLSNINVYACLVCGKYFQGRGPKSHAYFHALEVGHHVFINIGTKKVYVLPEGYEVNNKSLDDIKYVVDPHYTKNQVVKLDKEVHDAWDLSGSKYRPGFVGMNNIKANDYVNVVAQLLAHVLPIRNFFLLHEFPTPGTPEIILRFSTLVRKLWNPKAFRSHVSPHELLQEIAVRSSKRFTLTNQADPVDFLSWFLNCLHLALGGSKKPSPTPTSVVHAAFQGRVRIESQAITAHSDTQNARLVFTESGIINSQVTPFLILTLDLPPTPLFQSANRESIIPQVPLTTLLNKYNGYTASEKLAHRVRHRLLHPLPPYLFFHIKRFSKNRFVSERNPTIVTFPSPHSLDMSPYVEPNPNVCSPSDPILYDLVANIILDPAIAAPGAMDDAVEKGVNSASGAGGSSSGAGGGSEKVSWLVQLHDKAMEAENTRAKNGGSTEKQQQGPEWLEIQDLFVKRAESETLFAREGYLMVWERRKVPGNKGKGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>W6PW02</accession>
    <name>W6PW02_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="14">ABC transporter sequence aa5 from patent WO200132904-A2-Penicillium chrysogenum</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PROQFM164_S01g001767</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1365484.W6PW02"/>
    <dbReference type="OMA" id="QILWGEK"/>
    <dbReference type="OrthoDB" id="245989at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03233">
        <property type="entry name" value="ABCG_PDR_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03232">
        <property type="entry name" value="ABCG_PDR_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001465">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000054">
        <property type="entry name" value="ABC multidrug transporter atrF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034001">
        <property type="entry name" value="ABCG_PDR_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034003">
        <property type="entry name" value="ABCG_PDR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010929">
        <property type="entry name" value="PDR_CDR_ABC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19241">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06422">
        <property type="entry name" value="PDR_CDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="484"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="510"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="551"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="591"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="624"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="736"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1181"/>
            <end position="1200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1221"/>
            <end position="1247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1267"/>
            <end position="1286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1293"/>
            <end position="1315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1419"/>
            <end position="1437"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="123"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="816"/>
            <end position="1059"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="786"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="786"/>
            <end position="798"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDM27956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="1448" mass="161797" checksum="CB2222B282856171" modified="2014-04-16" version="1">MEQHPDDASLHSGYHNDEDEKNHTPVHKLNTHDFTSVETLHGPQPNLHESKSTETLNVDNEDDSPPPKKKAADWHMTSHVIRNAERDEAAGFKKRELGVTWQNLTVDVLAAEAAVNENMISQFNVPQLIKDWRRKPPLKSIVSESHGCVKPGEMLLVLGRPGSGCTTLLKLLTNQREGFHSITGDVRFGSMTPKEASAYHGQIIMNSEEELFYPRLTVGQTMDFAARLKVPFHLPEGVSVDEYTAETKAFLLESMGISHTAGTKVGNEFVRGVSGGERKRVSIIECLATRGSIYSWDNSTRGLDASTALEWAKALRAMTDVLGLTTIVTLYQAGNGIYDLFDKVLVLDEGLQIYYGPATEARPFMEKLGFIHTEGANVGDFLTGLTVPTERRVRPECERTFPRTADAIMAEYKKSSIYTREIATYDYPDSEICRERTEAFKESVAWERSNHLPKGSSLTISFWAQLIACTKRQYQILWGDMSTFIIKQVCSCIMALIAGSCFYDSPDNSLGLFTKGGAVFFSLLYNCIVAMSEVTESFKGRPVLLKHKAFAMYHPAAFSLAQIMADFPVLLFQCTIFSVVIYWMSGLKHTAAAFFTFWIILFSTTLCITAVFRFIGSAFSTFEAASKISGTAVKGIVMYAGYMIPKPKMKNWFLEVYYTNPFAYAFQAGLTNEFHDRTFPCVGRNLIPSGPGYEDVGADNQACAGVGGALPGANFVTGDQYLGYLHYKHSQLWRNFGVVWAWWGFFAVLTVIFTSYWKAAGNGGASLLIPREKLKAHNAAICDEEAQRNEKARNHETPDAPAEVDEGNLTRNTSIFTWRNLTYTVSTPTGDRVLLDNINGWVKPGMLGALMGSSGAGKTTLLDVLARRKTDGTINGSIMVDGRELPVSFQRMAGYCEQLDVHEPFATVREALEFSALLRQSRDTPREEKIKYVNTIIDLLELHDLADTLIGTTGNGLSVEQRKRVTIGVELVSKPSILIFLDEPTSGLDGQSAYNTVRFLRKLADVGQAVLVTIHQPSAQLFAQFDTLLLLARGGKTVYFGDIGENASSIKKYFGQYGAVCPTESNPAEFMIDVVTGGIEAVKDKDWHQIWLDSPEQSQMITELDRMIEDAASKPPGTVDDGYDFSMPLWDQIKIVTQRMNVALFRNTDYINNKFELHIISAALNGFSFWRPGPSIIALNLKMFSIWNFVFVAPGVINQLQPLFIQRRDIYDTREKKSKMYSWIAFVTGLIVSEFPYLCICAVLYFACWYYPVWRLPHDSNRSGATFFMMLVYELIYTGIGQFIAAYSPNATFAALVNPLIISTLVIFCGVLVPYDELNVFWRFWMYYLNPFNYVVNGMLTFGIWGAKVVCNEDEYAFFDPPNGTCADYLSDYMAGTGKGINLLNPDATSACKVCQYKSGSEFLNTLHIKNYTTGWRNIGIAWIFAFSGYALVFGLMKLRTKASKKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W6PW82</accession>
    <name>W6PW82_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g001991</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PW82"/>
    <dbReference type="OMA" id="FTENFLC"/>
    <dbReference type="OrthoDB" id="3016366at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054208">
        <property type="entry name" value="DUF6914"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21858">
        <property type="entry name" value="DUF6914"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM28180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="183" mass="20265" checksum="E7377CBD9A27EE93" modified="2014-04-16" version="1">MPDQTHPETKQTPTETKKKQAESLAGLPPNTLHIILYIRSDPPLPNDFHWAFYLHKGTATTPGGTKYHARGIGAGWIPGHEATASIFAENFLCVVIQIARIPPETHARVDEIMRSYDGCLNAIPGITCRVWILTVLRVLVDEGFVRCDIGELERECFGFGNENSLTASANLQPRPVFKSRVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W6PWC5</accession>
    <name>W6PWC5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Fps/Fes/Fer/CIP4 homology</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PROQFM164_S01g002364</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PWC5"/>
    <dbReference type="STRING" id="1365484.W6PWC5"/>
    <dbReference type="OMA" id="FQTHEVD"/>
    <dbReference type="OrthoDB" id="331602at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030139">
        <property type="term" value="C:endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032185">
        <property type="term" value="P:septin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09264">
        <property type="entry name" value="AP_Syp1_MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07650">
        <property type="entry name" value="F-BAR_Syp1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000102">
        <property type="entry name" value="WGS project CABT00000000 data, contig 2.23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001060">
        <property type="entry name" value="FCH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028565">
        <property type="entry name" value="MHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018808">
        <property type="entry name" value="Muniscin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049609">
        <property type="entry name" value="Syp1-like_MHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23065">
        <property type="entry name" value="PROLINE-SERINE-THREONINE PHOSPHATASE INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23065:SF54">
        <property type="entry name" value="SUPPRESSOR OF YEAST PROFILIN DELETION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00611">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10291">
        <property type="entry name" value="muHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00055">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51072">
        <property type="entry name" value="MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MHD" evidence="4">
        <location>
            <begin position="579"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="240"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="516"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="820"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="127"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="347"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="386"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="421"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="821"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="832"/>
            <end position="848"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDM28553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="873" mass="95835" checksum="490378D2130E75B5" modified="2014-04-16" version="1">MDLSRQEYPTLLASLHPSQATTVLSDRIRLINKVNTDIADYLQERRRVEEAYAQGLRKLAHRPQLDNGAALGIFQIPWQRIISATETLAVSHETLANKIEEDVERPLREFSTKNQEMKSLPGIQSSLAGLAKNVETAQKKVDKARARGARGADKLSSEIANAEEVHQQWDSRAPFVYEQLQAADETRLNHLRDVLTQLETHEVDQVERGRQAAESCLNILLNVETADEIKTFAARMAGPRVPTQAIPRRQTEPAETTFPIEPVSERTQTAPIDREFSTPTTEAPLPSLPRTHDDAESQLSEASERTTVAPTPPVPEAQQRHTPLGGLRRLGTVMNRRKSVVLPSTGSHDRKADKKRSPFAAFMRADSSRDMQIPESPPATGDRPGTSFTDQSSLRNPSMSQDRAGLDAGATMSEHPETRNGETNNHVNQPQVDAEGFTQRPATIDEITRAQNEAAGIDESGLNLTIRDQPIFEDENQAKRAMDDMANTLRMRAPQTGARRNAGTIRGRRDVRNTMFIASPSNEPPPSSAGSESQPPTSPIRHITSPSIAPSTDDHAMSDTTSVRSGHGPGASIHPDLYESGLNASIIETINAWFSEGNVTKSFVVGELALANNSPPGTVVDNARIRLDNFQVLEKVAANPHFVQEAKDTGDDSRGEYDIQLGNISRPMPTVAFKYQLHIDPSNPSAYCPVIFNPVWNLEEKQASAIIYYTLNPSFISHTTESITLKNLVLTINLDTATEDKTTKQPRESVAHAISAAMYPNTGATFRRKTSTVTWRIPELEVKAPTTPGADSKFLVRFMTSTPGPRKGTVEARFELRGAESASQLGISRSASETEQKEADPFADDGRDSPLSATSWLSVPTSRKLIGGKYVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W6PWH2</accession>
    <name>W6PWH2_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Arabinan endo-1,5-alpha-L-arabinosidase</fullName>
            <ecNumber evidence="4 8">3.2.1.99</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PROQFM164_S01g002056</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>Endohydrolysis of (1-&gt;5)-alpha-arabinofuranosidic linkages in (1-&gt;5)-arabinans.</text>
            <dbReference type="EC" id="3.2.1.99"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Glycan metabolism; L-arabinan degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.99" evidence="4 8"/>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PWH2"/>
    <dbReference type="STRING" id="1365484.W6PWH2"/>
    <dbReference type="OMA" id="GHLWAPD"/>
    <dbReference type="OrthoDB" id="195678at2759"/>
    <dbReference type="UniPathway" id="UPA00667"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046558">
        <property type="term" value="F:arabinan endo-1,5-alpha-L-arabinosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031222">
        <property type="term" value="P:arabinan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd18831">
        <property type="entry name" value="GH43_AnAbnA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.115.10.20:FF:000005">
        <property type="entry name" value="Arabinan endo-1,5-alpha-L-arabinosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050727">
        <property type="entry name" value="GH43_arabinanases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016840">
        <property type="entry name" value="Glyco_hydro_43_endo_a_Ara-ase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43301">
        <property type="entry name" value="ARABINAN ENDO-1,5-ALPHA-L-ARABINOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43301:SF3">
        <property type="entry name" value="ARABINAN ENDO-1,5-ALPHA-L-ARABINOSIDASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF026534">
        <property type="entry name" value="Endo_alpha-L-arabinosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004879456" description="Arabinan endo-1,5-alpha-L-arabinosidase" evidence="11">
        <location>
            <begin position="19"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="33"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="9">
        <location>
            <position position="199"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate" evidence="10">
        <location>
            <position position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR026534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDM28245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="320" mass="33909" checksum="21307B35AC48D1A1" modified="2014-04-16" version="1">MHFGNIIKPVLFAALVHGYANPGSCSGACNVHDPSLIQRSSDSRYFRFSTGNKISYASASSINGPWTTIGSILPSGSSIDLAGNDDLWAPDAQLVNGLYYVYYSVSTFGSQNSALGLATSATMDLGSWTDHGATGIASSSAKAYNAIDGNLFNAGGTYYMNFGSFWHDIYQAPMNSDATKVASSSYNLAYDSSGTHAVEGSYMYKYGNYYYLFYSAGICCGYDTSRPASGAEYKIKVCRSTSPTSGFVDASGTACTSGGGTVVLESHGTVYGPGGQGVFTDPSLGPVLYYHYVDTTVGYADSQKLFGWNQIDFSSGWPVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W6PWL2</accession>
    <name>W6PWL2_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Serine/threonine-protein phosphatase 2A activator</fullName>
            <ecNumber evidence="8">5.2.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Phosphotyrosyl phosphatase activator</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">rrd2</name>
        <name evidence="10" type="ORF">PROQFM164_S01g002459</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Acts as a regulatory subunit for PP2A-like phosphatases modulating their activity or substrate specificity, probably by inducing a conformational change in the catalytic subunit, a direct target of the PPIase. Can reactivate inactive phosphatase PP2A-phosphatase methylesterase complexes (PP2Ai) in presence of ATP and Mg(2+) by dissociating the inactive form from the complex.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the PTPA-type PPIase family.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="8"/>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PWL2"/>
    <dbReference type="STRING" id="1365484.W6PWL2"/>
    <dbReference type="OMA" id="SWIKINA"/>
    <dbReference type="OrthoDB" id="16120at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008160">
        <property type="term" value="F:protein tyrosine phosphatase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04087">
        <property type="entry name" value="PTPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1150:FF:000002">
        <property type="entry name" value="Serine/threonine-protein phosphatase 2A activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004327">
        <property type="entry name" value="Phstyr_phstse_ac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043170">
        <property type="entry name" value="PTPA_C_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037218">
        <property type="entry name" value="PTPA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10012">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 2A REGULATORY SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10012:SF5">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 2A ACTIVATOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03095">
        <property type="entry name" value="PTPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016325">
        <property type="entry name" value="Phstyr_phstse_ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140984">
        <property type="entry name" value="PTPA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0697">Rotamase</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="357"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="28"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="360"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDM28648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="417" mass="46148" checksum="E80F5DFBC65AF653" modified="2014-04-16" version="1">MASQAPLPSPTGKVDLSKKLSELRSNSRRGNPSSRDLTPATPPLPSPPDLSGHQYQQPIRRILSPKDHELFLASPTYKLVLAFIFGLTDSVRGHSIPDLQKKPQSESISKVLSVITQIRALLAKNPPIDQGGSRFGNPAFRALCDDVSAQSASWHTNILGLKDSGAIEEASTYLIHCLGSRERIDYGSGHELNFMMWLLCLYQLGLLPASDFPAVVIKVYVEYMHLMREIQSAYYLEPAGSHGVWGLDDYHFLPFLFGASQLVGHPYITPLGIHNTATLDEEGDNYLYLDQVRWVESVKLVKGLRWHSPMLDDISGSKNWAKVESGMKKMFVKEVLGKLPIMQHFLFGSLIPAAEGMTDSSERDAEHEHAHGHDHPHESSDWFGDCCGIKVPSTVAAGAEMRKRMGGGSDLRPIPFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>W6PWV6</accession>
    <name>W6PWV6_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Mitochondrial import inner membrane translocase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">tim10</name>
        <name evidence="17" type="ORF">PROQFM164_S01g000253</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="function">
        <text evidence="15">Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Heterohexamer; composed of 3 copies of TIM9 and 3 copies of TIM10, named soluble 70 kDa complex. Associates directly with the TIM22 complex, whose core is composed of TIM22 and TIM54. Interacts with the transmembrane regions of multi-pass transmembrane proteins in transit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Mitochondrion inner membrane</location>
            <topology evidence="1 15">Peripheral membrane protein</topology>
            <orientation evidence="1 15">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="15">The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the small Tim family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PWV6"/>
    <dbReference type="STRING" id="1365484.W6PWV6"/>
    <dbReference type="OMA" id="VGENMQK"/>
    <dbReference type="OrthoDB" id="274922at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045039">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.810:FF:000002">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit tim10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.810">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit tim13 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004217">
        <property type="entry name" value="Tim10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035427">
        <property type="entry name" value="Tim10-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11038">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11038:SF16">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02953">
        <property type="entry name" value="zf-Tim10_DDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144122">
        <property type="entry name" value="Tim10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 15" id="KW-0143">Chaperone</keyword>
    <keyword evidence="11 15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 15" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 15" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7 15" id="KW-0653">Protein transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 15" id="KW-0811">Translocation</keyword>
    <keyword evidence="3 15" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Tim10-like" evidence="16">
        <location>
            <begin position="17"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00055537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00065568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU367043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CDM26444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="92" mass="10056" checksum="02F836E8F2FEF70E" modified="2014-04-16" version="1">MSFLFGGAPKMSSAEKIAAAETEVEMISDMFNRLTESCTKKCVPADYREGDLNKGESVCLDRCVSKFFDVNIKVSEKMQGEANANKQGGGFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W6PXK0</accession>
    <name>W6PXK0_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g002486</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PXK0"/>
    <dbReference type="STRING" id="1365484.W6PXK0"/>
    <dbReference type="OMA" id="CSEMIRT"/>
    <dbReference type="OrthoDB" id="21214at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39472">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39472:SF1">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM28675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="434" mass="48059" checksum="65C9EE148D26533C" modified="2014-04-16" version="1">MSALEKMRELVGMGPSRELPQSRVDPSLAPPASVSSQHNTLVNCLLETCESDQSSVDEIAIDSDSSDSDDTVPGLSAPATIEGDTSPSPSKAFTRGHRRRSTHVTRRDLEKFQSEVLGVENHASWFDEDNGTSTPKSFTPDDPQLEELNRAFADADVSMNTNTSSMATNGNGNGNFSGYVENSSSAMSISNMPPRQTPSPSPSHTSVSGQINGGGMGAMGAAIPMNAGHQMDLHHLYEMVVELSDVLKNNRDVTKNIVANAEEIVKNGIVDSSGPNGQQGDNLTARIAELERALAKEKLVSADHKYHREENMKMVREFEHAVGIMLEQIRNYCQNNNMHYLAQKKHYNNLLQAERDAHLESRLDRDYWHAQTMKCAEMIRTAYRLKCEEDDVPTRVISGLQNEVRAYRFALGMEAEKPDEEYGWEYLKNIPGLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W6PYW8</accession>
    <name>W6PYW8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WD40/YVTN repeat-like-containing domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g000963</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PYW8"/>
    <dbReference type="STRING" id="1365484.W6PYW8"/>
    <dbReference type="OMA" id="SYEDSGR"/>
    <dbReference type="OrthoDB" id="3938623at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042594">
        <property type="term" value="P:response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045142">
        <property type="entry name" value="BCAS3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13268:SF0">
        <property type="entry name" value="BCAS3 MICROTUBULE ASSOCIATED CELL MIGRATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13268">
        <property type="entry name" value="BREAST CARCINOMA AMPLIFIED SEQUENCE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="326"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="452"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="574"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="754"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="578"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM27154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="1100" mass="118895" checksum="EDC673A36E3BB1FB" modified="2014-04-16" version="1">MLPAAPDDIIRQHSRLPEDDSPFAPDQHRTISEHEPSAKGKKKKGKKNKVARAATETPPDDIIQPYDPLPEEPLSCPDPEPFIERHVNPSITSPVLDVLGSLDEPAGDDLTSRTDTWAQSVPYGKSPPTDLMDGDIPSASLPSTSPLNFPTIQERSGFSHPSSASPQTRTLPSSYGNAYRSGLHSRQQSIDRRKSHSYGSPMSNHAPPPHLPQAHFFGAPDIEIIPTQNRSPAEGNYSFCGFDTLPSLSSKGSRTGMNVLLVGIDGAVEILAIEDRQTRLVGQITGLNGRVIEAKLLPGYPSSDPFASSRPHVAVIVHGPLPPHDEEGRVSSATSDANEIPPSTIRGHSYDKCARDDIQFYQTRVEIYSFRTSEHVCTLFASKPVPCLENLPGLPSFAPSPVGKLKIFTTGAYIILASGVSGEVYVYRHILSPETTAYQCLGKTWTGVQSKETRRYSTSSSSTTDPEGTRTDSPHGFSTLERPILAVQGRWLAFAPPSSAYRGSIQGTVPSSLIIGKVPGIETRSPPAVPSVSCATDVGEGESFFDKMARGVAQELVRGARWMGDQGMQAWNNYWNTQQPSGSSPRRPPQGLDLQTQGYGLFPPTHAQDTQTSATEPDTVSIIDLRRFEDGTDIRNAFIHPVSTFQVPNGCSFLSLSPNGLMLFTASKKGDVQYVWDLMQLKHCRSMAFMADDQTGQNPNVRQIARYARLTTSSIVDVIWTAPVGDRLAVITRKGTVHVFDLPRSAFQWPPFRRAKSTANKPPATDPMADEMTSQASGSNPLSAAMKLVGGKTQPFFSAVRGRVPSTGAAFPNMSGFALPSAASVKSGKVVAAGLSKSMGAATGTVNTLRHAGENRLHLPGLARDPAPSRVTWICNKGLIFLGVLDAGYFKMYRLKRATVPGHKSRQPHSIVGGKESQVKLPDNLQGPCGPAPLSTFDPEVVVHASIVLPSVSYQPSSAARSFCQPLSQAEIETNTPYQPFHTDQRVSLSVFSSGSDASEPSGQWVFGNDIPLIKVHLRSFNSSSDDHGDDEDENAVIHGHSLGAGGDIENLITLGNSTGNVEEVVITTRRKKRHSAPLKADDGFFEDDCEVLDFARDRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W6PYX0</accession>
    <name>W6PYX0_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Tetratricopeptide-like helical</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PROQFM164_S01g003027</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PYX0"/>
    <dbReference type="STRING" id="1365484.W6PYX0"/>
    <dbReference type="OMA" id="IAECHYK"/>
    <dbReference type="OrthoDB" id="5587616at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034080">
        <property type="term" value="P:CENP-A containing chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006335">
        <property type="term" value="P:DNA replication-dependent chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051730">
        <property type="entry name" value="NASP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019544">
        <property type="entry name" value="Tetratricopeptide_SHNi-TPR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15081:SF1">
        <property type="entry name" value="NUCLEAR AUTOANTIGENIC SPERM PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15081">
        <property type="entry name" value="NUCLEAR AUTOANTIGENIC SPERM PROTEIN NASP -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10516">
        <property type="entry name" value="SHNi-TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="Tetratricopeptide SHNi-TPR" evidence="5">
        <location>
            <begin position="224"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="86"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="198"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="390"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="336"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="91"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="154"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="426"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDM29215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="449" mass="49224" checksum="A7A7ABC2F8D8F225" modified="2014-04-16" version="1">MTDPQDGQSTVSEQEKRTQLDDLIAQAAAKDATKDYDSASELYSQATELQAELNGELSPENADLLYAYGKSLYNVAVSKSDVLGSKVAGEQQPQSGKASSTNISSAGSKSTSDSLVQDAITNSMAEKSSSTKRAGREPEPTSSKPFFQFTGDENFVDSEDEDEEPADQAEDDEEDDDFANAFEVLDLARVLYLKKLSAAEENDEGKGKSTTMSTDTKHIKERIADTHDLQAEISLEAERFREAVSDLRTVLELRNSLYPLEDPSVAECHYKLSLALEFASAQQGGEEDNNDKPKVDEEMRKEAATQMEYAITSCKVRMAQEEKKLEAEKDGDEDKATATKRKIANVKEIVTEMEQRLVDLRRTPVSIEQNDQANEAMLKGVLGQIMGQSATDQKAQLDAASKGATDLSAFVKRKPAKQPTQQPETASKRPAEEPAENDSKRSRVDDASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W6PZ74</accession>
    <name>W6PZ74_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">S-crystallin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S01g002842</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">FM164</strain>
        </source>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="4"/>
            <end position="83"/>
        </location>
    </feature>
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        <location>
            <begin position="92"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM29031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="236" mass="26060" checksum="7C5DA0D92EC42D5C" modified="2014-04-16" version="1">MSAPKIILYTNRVCPWAHRAHIALKELGLDYEEVTIDLNTPREPWYLKINPRGLVPTISYNGTIIAESGIVAQFLADAHQSHLLPPSSPTENAIYRARLSFFVDAFFSKVLPSFFASIRSADETERDAAAEQLVAAVVKEVEPLLADTEGKGPFFGGSEKLTLAEVQAGSFLLRILSFAKPEHGLVSAKLPALLEQAPRFKRWAEATVAHDSVNFIYDEKLVADKMRAKFAPAPKV</sequence>
</entry>
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    <accession>W6PZC8</accession>
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        <submittedName>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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            <authorList>
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                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
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                <person name="Goarin A."/>
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                <person name="Lacoste S."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
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    </dbReference>
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        <source>
            <dbReference type="EMBL" id="CDM29618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="39" mass="4531" checksum="0F81C2FBE6EF1E27" modified="2014-04-16" version="1">MITEIALLPDTLALQRNQDLMREFEKALEINLATHNHKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W6PZX7</accession>
    <name>W6PZX7_PENRF</name>
    <protein>
        <submittedName>
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    </protein>
    <gene>
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    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
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            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
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                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">FM164</strain>
        </source>
    </reference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <source>
            <dbReference type="ARBA" id="ARBA00008754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="159" mass="16948" checksum="9413AB3B0566CBF3" modified="2014-04-16" version="1">MSTPFRIVMACDEAGVPYKDAIKATLEKNPLVAEIIDVGVNSSSDKTAYPHPAVEGAKLIMDGKADRGLFICGTGLGVAIAANKVPGIRAVTAHDPFSVERSILSNDAQVLCMGQRVIGVELAKKLATDWLNYRFDPKSASAAKVQAITDYEIQFHTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q046</accession>
    <name>W6Q046_PENRF</name>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
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                <person name="Debuchy R."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
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        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM27584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="123" mass="13989" checksum="BC0A1E1D4DDA36B8" modified="2014-04-16" version="1">MHCLSSGSLRPLLPNWILSLWRSEREQSGERLDQTVPNSSSPYTGTEPAVYELQNTKFSYNATMPLPVCISNQTERTAWTRTPLSNRPRAISMKPNDKTDCETIELPDVVFVEGKVYLRERGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q174</accession>
    <name>W6Q174_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S02g000219</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
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        <lineage>
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                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q174"/>
    <dbReference type="OMA" id="FKDPHNS"/>
    <dbReference type="OrthoDB" id="4289430at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM30070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="162" mass="18611" checksum="CE219A1A62DED311" modified="2014-04-16" version="1">MPFLQASVFQSSQLEHGHQFHFKDPHNSQPGWLWGTVTLPDTMGLGTSDKEIIVHICETIAAGLVTWSDSAMHGLGKYCISFPIKLETPKQDLKRLMIQVEYAALWWVSFIRAETVSIDKHMLFRARQPPPDREDQLLDVPFHWDKPDYTALNPWSVVTVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q1M2</accession>
    <name>W6Q1M2_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glucan synthesis regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">gs-1</name>
        <name evidence="4" type="ORF">PROQFM164_S01g001925</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the KNR4/SMI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q1M2"/>
    <dbReference type="STRING" id="1365484.W6Q1M2"/>
    <dbReference type="OMA" id="ESLMVHD"/>
    <dbReference type="OrthoDB" id="2305498at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070880">
        <property type="term" value="P:fungal-type cell wall beta-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1580.10">
        <property type="entry name" value="SMI1/KNR4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009203">
        <property type="entry name" value="Knr4/Smi1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018958">
        <property type="entry name" value="Knr4/Smi1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037883">
        <property type="entry name" value="Knr4/Smi1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051873">
        <property type="entry name" value="KNR4/SMI1_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47432">
        <property type="entry name" value="CELL WALL ASSEMBLY REGULATOR SMI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47432:SF1">
        <property type="entry name" value="CELL WALL ASSEMBLY REGULATOR SMI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09346">
        <property type="entry name" value="SMI1_KNR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017023">
        <property type="entry name" value="KNR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00860">
        <property type="entry name" value="SMI1_KNR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160631">
        <property type="entry name" value="SMI1/KNR4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Knr4/Smi1-like" evidence="3">
        <location>
            <begin position="156"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="21"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="229"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="372"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="233"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="390"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="458"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="482"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="502"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM28114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="521" mass="57560" checksum="9F75879510B16064" modified="2014-04-16" version="1">MANMLNSTWRSFWHTMTSYDRHASHDSPYRTGGHVPLSQSRHEPLTSVATSAIESRPDLSNPYDDEPTKGSARAQASEWNGSDDLGSPTHPYSPGMRSVASQKRRSNDQGEGAPEIQMQSFHDGAPPPPPVAHSWRKIERWLEHNYEELLDQLGEGCTQNDINELEHELDCSLPLEVRESLMVHDGQERGGLPTGVIFSAMLLDCEEIVQEWRNWRKVNDEYLSNATIPPAPSSAASSSAAGPSQQPSSTMWQSELLDRQDSQPPGAVQKAYSHPAWIPLARDWGGNNLAIDLAPGPAGKWGQVIIFGRDYDCKYVVARSWSSFLATLADDLCSGDVIVDEETNELKLKQFKTQNVEPPYLDILRWRTDQKYGRRVPRRKGPVPNGLGVSASGNRSSSRESPYGSPTRAEERGRSPHRFSKGGNSQSPKTPFGVSSPLARVTEETTSPVVTAGPTISEDTKENKEPQTEDLMEIVTPQISNKENEGFSKPKELKESEKTDSAESSTAIESEILGEMKNVAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q1V1</accession>
    <name>W6Q1V1_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ribonuclease H</fullName>
            <ecNumber evidence="3">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PROQFM164_S02g000399</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11 12">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RNase H family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="3"/>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q1V1"/>
    <dbReference type="STRING" id="1365484.W6Q1V1"/>
    <dbReference type="OMA" id="CMDNGRP"/>
    <dbReference type="OrthoDB" id="407198at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043137">
        <property type="term" value="P:DNA replication, removal of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13934">
        <property type="entry name" value="RNase_H_Dikarya_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050092">
        <property type="entry name" value="RNase_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10642">
        <property type="entry name" value="RIBONUCLEASE H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10642:SF26">
        <property type="entry name" value="RIBONUCLEASE H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="8">
        <location>
            <begin position="86"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM30250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="261" mass="30048" checksum="81B8DADEE5C34891" modified="2014-04-16" version="1">MLNLEAMAYQTTMSFHQVNPAQYFAPHMLPRLYTELRVGSGRVIPTEFAPPHPNDTPQSLFPHCPKVTATDRVHRFIRLNHDNRSVEDEFLILTDGTCMDNGRPNARAGCSFVYNESASGYARFPLEYKGPTGQQHTLTNDRAQIRAVIAALRYRDWAMDGFSRLIIATDSEYVVDGITREVYDWIQYSWVTRAGEPIRNRDLWECLLGEVEMWEERGMSVQFWRVPRTSEMKADRHAKTAAFLDRHREFTDVAGISNVSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q2B4</accession>
    <name>W6Q2B4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Heat shock factor binding 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S02g000833</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HSBP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q2B4"/>
    <dbReference type="STRING" id="1365484.W6Q2B4"/>
    <dbReference type="OMA" id="MTAEDDN"/>
    <dbReference type="OrthoDB" id="4159489at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070370">
        <property type="term" value="P:cellular heat acclimation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009643">
        <property type="entry name" value="HS1-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19424">
        <property type="entry name" value="HEAT SHOCK FACTOR BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19424:SF0">
        <property type="entry name" value="HEAT SHOCK FACTOR BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06825">
        <property type="entry name" value="HSBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="23"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM30683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="89" mass="9342" checksum="9B23D3E4F00A8DEB" modified="2014-04-16" version="1">MADESKSPSPDKLESSLPEGKSLLSQPNSDAQGQLTAAVDDLLNELQSKFDNVSTEMFGKLDDMTKRLDELEASLAAASSGTGAPSPTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q2Z3</accession>
    <name>W6Q2Z3_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S02g001088</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q2Z3"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="43"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM30938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="60" mass="6362" checksum="9C944A7685F6C02A" modified="2014-04-16" version="1">MSPCTCNCCSGECTSCSCSSCKGKRYTNYPPSTKPTHRPSSPPSSSHTTHTRPGLPLLSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2024-10-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q3B7</accession>
    <name>W6Q3B7_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S02g001243</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q3B7"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM31093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="56" mass="6781" checksum="204511684A7180EE" modified="2014-04-16" version="1">MPFATLPHREEHSHVFRKHSQVTHTKLLGLNRRSGQTQQHQIIKEWAETMPRHRFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q4U1</accession>
    <name>W6Q4U1_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8">Ubiquitin-like modifier-activating enzyme ATG7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Autophagy-related protein 7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">atg7</name>
        <name evidence="12" type="ORF">PROQFM164_S01g003021</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 and ATG8 for its conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Autophagy is essential for maintenance of amino acid levels and protein synthesis under nitrogen starvation. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Plays a role in the regulation of filamentous growth and chronological longevity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Preautophagosomal structure</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the ATG7 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q4U1"/>
    <dbReference type="STRING" id="1365484.W6Q4U1"/>
    <dbReference type="OMA" id="RQIWDAI"/>
    <dbReference type="OrthoDB" id="338614at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019778">
        <property type="term" value="F:Atg12 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019779">
        <property type="term" value="F:Atg8 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006995">
        <property type="term" value="P:cellular response to nitrogen starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032446">
        <property type="term" value="P:protein modification by small protein conjugation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01486">
        <property type="entry name" value="Apg7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.70:FF:000001">
        <property type="entry name" value="Ubiquitin-like modifier-activating enzyme atg7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000243">
        <property type="entry name" value="Ubiquitin-like modifier-activating enzyme ATG7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.100">
        <property type="entry name" value="Ubiquitin-like modifier-activating enzyme ATG7 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.70">
        <property type="entry name" value="Ubiquitin-like modifier-activating enzyme ATG7 N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006285">
        <property type="entry name" value="Atg7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032197">
        <property type="entry name" value="Atg7_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042522">
        <property type="entry name" value="Atg7_N_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042523">
        <property type="entry name" value="Atg7_N_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01381">
        <property type="entry name" value="E1_like_apg7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF3">
        <property type="entry name" value="UBIQUITIN-LIKE MODIFIER-ACTIVATING ENZYME ATG7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16420">
        <property type="entry name" value="ATG7_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0072">Autophagy</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin-like modifier-activating enzyme Atg7 N-terminal" evidence="11">
        <location>
            <begin position="1"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="10">
        <location>
            <begin position="376"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="307"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="7">
        <location>
            <position position="575"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR606285-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDM29209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="711" mass="79599" checksum="D9E5DA66A1AFC030" modified="2014-04-16" version="1">MQYAPFASDIELPFYTSLASHKINHDKLDDSARPVLGLYEIRPSDPEAASCRIQIHGNALTSSEVPAGYYRAEGMIKNVNTVEEYRNMDRSKLLYQAGQMIWDAIHDGTILSCPSLLCSFVIVSFADLKKYKFHYWFAFPAIHSDPQWVPVQPTDQVSQPHQDNSLDNLKGIHLSPHESTALVEAVETWSYMVDPRQRGFFLARKVRENSDNASSGDSETKNAQQGDTSNINWQIASLSEYENGFFKNVATEDRYFCFADPSNYEQAPGWMLRNLLVLIKQRWGIERVQLIRYRDVHARRDQGRSTVIQLESSSKQETETPRSLQSQGSLPLPKVTGWERNSTGKLAGRIVNLTEYMDPKRLADQSVDLNLKLIKWRISPTLDLEKIKNTKCLLLGAGTLGSYVSRNLLGWGVKKITFVDNGTVSFSNPVRQPLFNFEDCLNGGVQKALRASEALTQIYPGVDTKGYVFSVPMAGHPIVDEAATRADFDRLKTLIDEHDAIFLLMDTRESRWLPTVMGKAAGKIVMNAALGFDSFVVMRHGIMEDENPAELGCYFCNDVVVPANSIKDQTLDQQCTVTRPGVAPIASALLVELFVSILQHPRGAAAPAPIARNTERDDHPLGSVPHQIRGFLSNFENLSVTGKSYSSCSACSDKIVSAYREHGWDFVRKALNEHGYVEELSGLREVHEKAEAALADIDWDEASDNEEIEIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q5T5</accession>
    <name>W6Q5T5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AAA+ ATPase domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S02g001486</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
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            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
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</entry>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
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                <person name="Abraham A.L."/>
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        <source>
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        </source>
    </evidence>
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</entry>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
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                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </reference>
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        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23519">
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        <property type="match status" value="1"/>
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        <property type="entry name" value="MFS general substrate transporter"/>
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    <proteinExistence type="inferred from homology"/>
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            <end position="111"/>
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            <end position="141"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="9">
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            <end position="175"/>
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            <end position="235"/>
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            <end position="270"/>
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    <feature type="transmembrane region" description="Helical" evidence="9">
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            <begin position="405"/>
            <end position="425"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="9">
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            <begin position="437"/>
            <end position="462"/>
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    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="474"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00006978"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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        <source>
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    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363073"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CDM31686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="527" mass="59172" checksum="67A48C4725C35147" modified="2014-04-16" version="1">MDQQKDNIHSTVEVDGLPQNKIDDPIAPDVFDERYRTTRTEIWAYYAYYIGNNGLSLFNFAPTAFQNLLSQAVPADGLLDFLGRPRNVNSIVLLSNGISFAIQVVVFLIIGSFADFGYWRPNILIALSIIAWGIGFGWLGVHTPDKWRIGVGLYMVGLIAYQTTLTFWTAAFPGLARNSIELKEEADKYVAGSITREEYDYADTMMRSKLANVAFYVQSVGEIFILAIIVGIMFGLKVNDSETNNNWGVSVLIAFVSGVWLLVSIPWFILEKRRPGQDPGKRSIFVAGMWQLWHAMKQIWHLKQSLCYLVGYFLLGDSLNTTVTVIGTLQNSIVSYNTLELTYLLIVGIAAQGAGIYAFWTIQQRFRLGTKTMFNAVAVGIILLDGWGMIGIWTQRFGFHHAWEVWVYQAFYGLFICPWYSYSQIMISEVTPRGHEFLFFSLFSIIGKTSSFIGPIVSSAIIDASPSGNVSLPFYFLFGLSVASFLILFWGVDLKKSQEEQQRFLSDKLRRLNASASSSDDETSAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q6X7</accession>
    <name>W6Q6X7_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="5">YTH domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PROQFM164_S02g002619</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q6X7"/>
    <dbReference type="STRING" id="1365484.W6Q6X7"/>
    <dbReference type="OMA" id="FWEVESS"/>
    <dbReference type="OrthoDB" id="306690at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990247">
        <property type="term" value="F:N6-methyladenosine-containing RNA reader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000381">
        <property type="term" value="P:regulation of alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21134">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.590.10">
        <property type="entry name" value="ph1033 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057720">
        <property type="entry name" value="RRM_YTH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007275">
        <property type="entry name" value="YTH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045168">
        <property type="entry name" value="YTH_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12357:SF3">
        <property type="entry name" value="YTH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12357">
        <property type="entry name" value="YTH YT521-B HOMOLOGY DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25701">
        <property type="entry name" value="RRM_YTH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04146">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50882">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="251"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="YTH" evidence="4">
        <location>
            <begin position="396"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="164"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="326"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="514"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="19"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="172"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="185"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="214"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="228"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="348"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDM32468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="595" mass="64641" checksum="407F8D4FB1019B99" modified="2014-04-16" version="1">MGNVPSDKTADETAPISEQGASPTSAPRPNVTHHSSFAEARYGTAPSPLNMVMGYNFPGHHPQGYNPQSMHQYTAHGQGMMYPMPMTPYGHNSGGMPYGMSYPAYPPYAIPQHPGPQPQHHYPPHGTQMQNMPNLNPGQVSPYSSGYYPHSSYGPYGHGVPAGQMPQAISPVRTNTSSPSKPVTLRKEADKRMTDLEYDVSKTIVDGSNPKKIAQSQPQPPFSNNTPPSQPLPTAPSTPRGPPRKPKQSGHALWVGNLPPGASVIDLKDHFSQDAKNDIESVFLISKSNCAFVNYKSAAACVAALARFHDSRFQGVRVVCRLRKGLTAPGSGSAAPNNALRPRPEDNATATTTITTATTTATTTATDPGEDHSITPEPGSAAPATGNHPPPARLVDRYFIVKSLTVEDLELSKQSGIWATQSHNEAAMNQAFENTDYVYLIFSANKSGEYFGYARMMSPISDDEELALEMPSRPDPPPGGPDELDVTLTAATSTAPQGRIIDDSVRGTIFWEVESSEDENDNASEKSVEPEDPEEGQTFGKPFRIQWISTERVPFQRTRGLRNPWNANREIKIARDGTEIEPTIGRKLIQLFHLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q7J6</accession>
    <name>W6Q7J6_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S02g002122</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q7J6"/>
    <dbReference type="OrthoDB" id="4526503at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM31971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="173" mass="19822" checksum="EC795B7B7852211D" modified="2014-04-16" version="1">METGSYDLDHFFNLDTDQGRPKLDTGQGRPALAGNEIWVILRALRPVPSDPKSLPSDPVSSSRYRDRRRFTLVYSWHSRVLAGYFDGQVHVQFTRILDFKEYAVIPPEDTPYIDTIDKGKLYDMLNMLAKWSWPIPVATTKEYTGVILDLPTHDHPDTELADDDWLLVQGVTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q7Q6</accession>
    <name>W6Q7Q6_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="7">N-terminal acetyltransferase A, auxiliary subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PROQFM164_S02g000403</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SGT family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q7Q6"/>
    <dbReference type="STRING" id="1365484.W6Q7Q6"/>
    <dbReference type="OMA" id="DMARNMM"/>
    <dbReference type="OrthoDB" id="2335338at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072380">
        <property type="term" value="C:TRC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006620">
        <property type="term" value="P:post-translational protein targeting to endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.420:FF:000005">
        <property type="entry name" value="Hsc70 cochaperone (SGT), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000207">
        <property type="entry name" value="Small glutamine-rich tetratricopeptide repeat-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.260.100:FF:000011">
        <property type="entry name" value="TPR Domain containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.420">
        <property type="entry name" value="Immunoglobulin FC, subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047150">
        <property type="entry name" value="SGT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032374">
        <property type="entry name" value="SGTA_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45831">
        <property type="entry name" value="LD24721P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45831:SF2">
        <property type="entry name" value="LD24721P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16546">
        <property type="entry name" value="SGTA_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13414">
        <property type="entry name" value="TPR_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 4" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SGTA homodimerisation" evidence="6">
        <location>
            <begin position="6"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="104"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="172"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="79"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="199"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="79"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="209"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM30254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="357" mass="36657" checksum="B35640AD8B39CEF9" modified="2014-04-16" version="1">MAPTESNKRLALAIIDFLGSSLKDGTLTADDAESIEIAQSCIADTFKVDPTDEAAVKDAVGGQSLAGIYNVYEKLRNKSTPQSTAGAQNSQEEKPKAGVPTPESDKLKSEGNALMAKKDYAGAIEQYTKALEIAPANPIYLSNRAAAFSASGQHEKAASDAEVAAAADPKYSKAWSRLGLARFDMGDYHAAKEAYEKGIEAEGNGGSEAMKRGLETSTRKLEETTRTTEPPSEELDTAPGASRGGPGGMPDLSSLASMLGGGGAGGAGGMPDLGSLMSNPMFSTMAQNLMSNPDMLGNLMSNPRLRQMAESFGQGGGMPDMSSLMSDPNLANMARNMMGGGGAGAGAGAGTGSEGPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q7Z3</accession>
    <name>W6Q7Z3_PENRF</name>
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        <submittedName>
            <fullName evidence="3">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
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        <name evidence="3" type="ORF">PROQFM164_S02g000513</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
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            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q7Z3"/>
    <dbReference type="OMA" id="TACWAQL"/>
    <dbReference type="OrthoDB" id="3918601at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38794">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38794:SF1">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="2">
        <location>
            <begin position="31"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM30364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="344" mass="38316" checksum="28C2572E407D2C61" modified="2014-04-16" version="1">MGTRFKGDTKDPAVNVTTWVLLVIIIFSVSARLGTKVRLFKRLSTDDLLIIASLIVGIGQNIAVSLAVGSGYGKHSKDVSSANMQQVMKDLFAVSLLYLLSLMFSKLSLVVFIRSLTPSAKDKWLARGVEAIVYVWAVVAIFGTAFQCSLPRAWDFQNGQCINLLTWRYFVAISNIVTDLLIVAQAMILISSVQTTLLRRLAFAGIFLPRLLVTIATVGELAFIKKGTESNDPTFQMCEITIFEVAIQCLSIVTACWGQLSPFLSWMRSNGLKLNGVEDPTSWSYKIRSQSQGRSKSRDRKIRSESHELPPLLIRRDQILVTQDWELDSQSSQAHIVTEFDTQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q894</accession>
    <name>W6Q894_PENRF</name>
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        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q894"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM32928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="82" mass="8929" checksum="22D9BB9650EF9A3B" modified="2014-04-16" version="1">MKRARSCSPVPLPPNHRKIVRTVASLTSDALQEHDDSIQPLSPLALFDMFPQQIASLSDVPIIPPPSTRSSTIAIEQSVPTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q8B0</accession>
    <name>W6Q8B0_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S02g003089</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q8B0"/>
    <dbReference type="STRING" id="1365484.W6Q8B0"/>
    <dbReference type="OMA" id="PFEHLLW"/>
    <dbReference type="OrthoDB" id="5295335at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="221"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="311"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="340"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="247"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM32938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="418" mass="45968" checksum="03085DF9E8021C42" modified="2014-04-16" version="1">MSDQGGVLGAFGAVLGYIGAEAATEIWFSSLLWPQRSFSHITLRSIPTLALLMPMGGPLHKAALSTFDIANARGLLKGAHEGHMLGTSFFEQTDWTYTICGTATSEPRAARNCMWARALHYMPIPAEKPGSLAGLSPPATDAAIEKGILPPTDNGRIPLRAKVAVYHLIFTPATAEDKASQMAFVRENCGRPGWHVYLSILIAELSGIILFAVVYAIGRSLWCLIWLAPLLLRLLSAFFALDHEPLTPVSSSTSSPSTTPTTEAEPPRDFVLQSPQSQGGDLMLFTGLPALVQQFFRHYGHPVRNRPREILQLSIIALFAALFPLGLLASTLWMPPLVQYAWTCYQIYIVLTMHIVRYTSFGRNTNTESKVADYLADRPAILFGEKRHGAETVKVSLIATYHARHQEGRDCLERLVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q8J2</accession>
    <name>W6Q8J2_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S02g002422</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q8J2"/>
    <dbReference type="OMA" id="ITPACYL"/>
    <dbReference type="OrthoDB" id="4361168at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM32271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="129" mass="14406" checksum="382D0D7832082A4E" modified="2014-04-16" version="1">MKEFAVLLHNTRELVVTPIVLVELPKELVMTIDNSITETYNNSINTKANTSISMSQSSIAITPACYLCHDPRHLQRRCPLFALWKSAVETLCRDHTIDPMNLLEQIDIGILVTALASALPDRDGDISMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q8M9</accession>
    <name>W6Q8M9_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial</fullName>
            <shortName evidence="7">Glu-AdT subunit B</shortName>
            <ecNumber evidence="7">6.3.5.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PROQFM164_S02g000739</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>L-glutamyl-tRNA(Gln) + L-glutamine + ATP + H2O = L-glutaminyl-tRNA(Gln) + L-glutamate + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17521"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="Rhea" id="RHEA-COMP:9684"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Subunit of the heterotrimeric GatCAB amidotransferase (AdT) complex, composed of A, B and C subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the GatB/GatE family. GatB subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.-" evidence="7"/>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q8M9"/>
    <dbReference type="STRING" id="1365484.W6Q8M9"/>
    <dbReference type="OMA" id="ARKWWMG"/>
    <dbReference type="OrthoDB" id="1722066at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030956">
        <property type="term" value="C:glutamyl-tRNA(Gln) amidotransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050567">
        <property type="term" value="F:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070681">
        <property type="term" value="P:glutaminyl-tRNAGln biosynthesis via transamidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00121">
        <property type="entry name" value="GatB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017959">
        <property type="entry name" value="Asn/Gln-tRNA_amidoTrfase_suB/E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006075">
        <property type="entry name" value="Asn/Gln-tRNA_Trfase_suB/E_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018027">
        <property type="entry name" value="Asn/Gln_amidotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003789">
        <property type="entry name" value="Asn/Gln_tRNA_amidoTrase-B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004413">
        <property type="entry name" value="GatB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023168">
        <property type="entry name" value="GatB_Yqey_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017958">
        <property type="entry name" value="Gln-tRNA_amidoTrfase_suB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00133">
        <property type="entry name" value="gatB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004012">
        <property type="entry name" value="PRK05477.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11659">
        <property type="entry name" value="GLUTAMYL-TRNA GLN AMIDOTRANSFERASE SUBUNIT B MITOCHONDRIAL AND PROKARYOTIC PET112-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11659:SF0">
        <property type="entry name" value="GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE SUBUNIT B, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02934">
        <property type="entry name" value="GatB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02637">
        <property type="entry name" value="GatB_Yqey"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00845">
        <property type="entry name" value="GatB_Yqey"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89095">
        <property type="entry name" value="GatB/YqeY motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="Glutamine synthetase/guanido kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01234">
        <property type="entry name" value="GATB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Asn/Gln amidotransferase" evidence="8">
        <location>
            <begin position="422"/>
            <end position="586"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM30589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="588" mass="65700" checksum="1A948CB0E47CD89F" modified="2014-04-16" version="1">MLRSCIGGGTLRSLCVRRLTRSALSSTKAQFSSAPTRYLQPPASADRVPLRKQLKEEAKALRSHKRQRKETEEASREEWELTVGVEIHAQLDTETKLFSRAATSISDIPNSNVALFDLAFPGSQPAFQIATLLPALRAAIALNCEIQRVSRFDRKHYFYQDQPAGYQITQYYEPFARNGYVDLFDYDGIAPEDGERIRIDIKQLQLEQDTAKSQEYRGSRQLLDFNRVSHPLVEIITMPQIHTPATAAACVRKLQAILLSCGAVTTGMEMGGLRADVNVSVRRRGEAPGQYQYDGISGLGQRTEIKNLSSFKAVEDAIIAEKNRQIEVLESGGVVEGETRGWTIGSTETRRLRGKEGSVDYRYMPDPDIPPLVIGEDLLSSLRASIPTAPDTVLTLLVGSEFNLPIEDAKPLIELDNGARLEYYHDVVDILRTLQVDQDDKTRAGLTRVASNWVLHELGALLAKADQAWDAETVPARSLAHLIDHLQRKLITGPTAKLVLTTIFDGDQRPVPQLLEEENLLLRPLSREEYLALAESVIALNPQMVEQIRSKKQLGKLGWFVGQMMRNGEKGRVEALKAEEVLRELILR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q958</accession>
    <name>W6Q958_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Lysine-specific permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LYP1</name>
        <name evidence="10" type="ORF">PROQFM164_S01g000076</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q958"/>
    <dbReference type="STRING" id="1365484.W6Q958"/>
    <dbReference type="OMA" id="MFAYLAV"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000006">
        <property type="entry name" value="General amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004762">
        <property type="entry name" value="Amino_acid_permease_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00913">
        <property type="entry name" value="2A0310"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF4">
        <property type="entry name" value="ARGININE PERMEASE CAN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="87"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="166"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="195"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="291"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="330"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="388"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="418"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="465"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="495"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="9">
        <location>
            <begin position="59"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="30"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDM26267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="554" mass="60623" checksum="C491D1C2C5019412" modified="2014-04-16" version="1">MSDMVSHDASAAHDTKTSANVISVESDNVFRDTKESDAEQNHADTSNSGELKRRLKSRHLQMIAIGGTIGTGLFISSGTAIAESGPAGALIAYIFVGSIVYSVMSSLGEVATYIPMPGAFTSYAARLIDPSLGFSMGWIYWFNWASTFAVELTATGTIIQYWDPSLNIAIFIGVFWVFITAMNFLPVNFYGEVEFWFSTIKVATVVGFIIFAICIDVGVGEQGYLGFRYWSTPGAFATYSPHLPVSVGKFVGFWAVLIQAGFSYQGTELVGVAAGETENPQKTVPSAIRKTFVRILLFFVLTIFFIGLVVPYDNGRLTTATTNASSSPMVIAADLAGVKVLPSLINAVLLSVVLSAANSNVYSGSRVLTGLAHEGFAPACFGWVTKHGVPYISVTFTALFGLLGFMNVSNDAGQVFTWLVNLSSVAGFVTWASINACHISFMRVLATRGISRDTLPYKAFLQPYLAWYGLFFNVLIALTQGFTSFIPHFRVTDFFVAYICPIVFVVLYIGHKVIFRPSFVRAADADIDTGRLHYQKQIDPPMPWYWRAWGWFTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q9K9</accession>
    <name>W6Q9K9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S02g003251</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM33100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q9K9"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM33100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="56" mass="5997" checksum="D598145FE4AD9BF4" modified="2014-04-16" version="1">MILKAAFFTGYGKMVSEPENGVRLGDIPGPREKPRDSWPSGSSPHSLPADGVKSQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q9R1</accession>
    <name>W6Q9R1_PENRF</name>
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        <submittedName>
            <fullName evidence="3">F-box domain, cyclin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S03g000102</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q9R1"/>
    <dbReference type="STRING" id="1365484.W6Q9R1"/>
    <dbReference type="OMA" id="SRLDRKW"/>
    <dbReference type="OrthoDB" id="550575at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:001369">
        <property type="entry name" value="F-box domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057207">
        <property type="entry name" value="FBXL15_LRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318:SF190">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25372">
        <property type="entry name" value="DUF7885"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="179"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="607"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="700"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="50"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="607"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="711"/>
            <end position="721"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM33378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="736" mass="81403" checksum="CA78C92BDFDDCE0F" modified="2014-04-16" version="1">MASQVSDGALPSPGSISPNIPTNSTGQIPLEQPPKLKGRRKLLQSLQRMSSSPTLTRRGRSSSTTGYHRDNKASLSCVSLSSTSYSPCLGNGSSSQLYGGLNPRSATPGCSGSPGESQGANARIRLMETDGPGFPVPRTVPMPSDMRPASRGSPRSATPVDVKVETEVILPESQPARSFDFWGDMPQELKVKIFQYLTPQEIVCCAPVSKAWNEMCYNGQLWSKVDTTEYYSKIPGDVLLKLITCGGPFVRDLNLRGCVQMREKWSSDGDRISDLCRNVVNLSLEGCRIEKESIYTFLLRNPRLEYINLSGLSNVTNSAMKLIARSCPQLATLNVSWCRNIDTSGLIRIVQSCWRLRDLRASEIRGFKDEKFTLALFERNTLDRLIMSRTDLTDQSLKMLIHGENPEMDILTDRPIVPPRKLRHLDLHNCPEVTDDGFKSLAHNVPDLEGLQVSQCSELTDESVIDVIRTTPKLSHLELSDLENLTNATLVQLAESPCAQELEHLNISYCESLSDTGMLRVMKNCPRLRSVEMDNTRVSDLTLMEASFRVRRRGYSDDLPQIGMRLMIFDCANVTWAGVREVLSSNAYIPRASRKAVATVVTVTQTSDASSPSTSTFVTPASSPSPSPAPTYPNEIIQLKCFYGWQMTVDEHTKRVLRGDLTAASRLDRKWAEYMVATEEAGATGAGARRRRRRAREAERLYNEDEDENDASGVGSVSAPGGRRRRAQSGGSCIVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q9T1</accession>
    <name>W6Q9T1_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Genomic scaffold, ProqFM164S03</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S03g000132</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q9T1"/>
    <dbReference type="OMA" id="HRDTEFN"/>
    <dbReference type="OrthoDB" id="5397734at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056009">
        <property type="entry name" value="DUF7587"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24494">
        <property type="entry name" value="DUF7587"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7587" evidence="2">
        <location>
            <begin position="135"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="366"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="476"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="97"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="418"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="443"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM33408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="543" mass="61982" checksum="4318B3A0917AF6A8" modified="2014-04-16" version="1">MPFSLSQRIADEITMMSLSRSRKRTDQLENNESVVTSHGKICLWCNRELIIDGTDGRDDQSQPTRPNQAIISNQNQQFQHRHQEHQDQDQQDHQECQEPQYQHQDQQGCGQQHHGRQGHHIDHELAMQGVPADKMPPLLFRWSNRDSQGINSKTMFVAGLFCNGDWFDSEDCSGDRFEGFFRSHVSKQKVRTPFISTFRSPLAPLHRAIAGQNGAIVTVIDTSKLETKVFYAHPLAIRTGTLVYNGWQGYGEYLIWGRVPAEAIAFSVDIVSLEGITQSHRDLNRLVQIPLIRSSLRCSDTLRDMLALRRKSPFQSGRTLGKFLTLLQVPRIHWANLASEFARAWGWRNARETKIFYSGVKSAPPYLPEELTDSESEAPWPTPRKTPWQTPQKMHFSPDCVPDLDYEPPETDERSEGTSESEGVSSSQTMSMCDKTETADDGNFSTHETLSSGIFPENNGSEDFLAHIHSQEAIDLTSDNEDTSSQRALQRDWPSDDDTYMYPDTPTKIRGKISLHSDNKATYRPVLNGQMDMDFFEKFRLWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W6QA02</accession>
    <name>W6QA02_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pyridoxal phosphate-dependent enzyme, beta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PROQFM164_S02g002967</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM164</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QA02"/>
    <dbReference type="STRING" id="1365484.W6QA02"/>
    <dbReference type="OMA" id="YVIAGHG"/>
    <dbReference type="OrthoDB" id="4418812at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003941">
        <property type="term" value="F:L-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004794">
        <property type="term" value="F:threonine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006565">
        <property type="term" value="P:L-serine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006567">
        <property type="term" value="P:L-threonine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050147">
        <property type="entry name" value="Ser/Thr_Dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48078:SF11">
        <property type="entry name" value="THREONINE DEHYDRATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48078">
        <property type="entry name" value="THREONINE DEHYDRATASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="4">
        <location>
            <begin position="60"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDM32816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="379" mass="41365" checksum="C2E71C703DD5073E" modified="2014-04-16" version="1">MSQVFTCYVSSKFNGSTPDCAVNIELVRGALGSTKSQVHNACCSNPDYAQLIVMSRVHDMIRSTDLSPAHNLSRHVDFQLYLKREDQQLSFSPHVRGLYNSMSHITPENRWRGVVIPSKGQYARAIAYSARLLNIPAVILVGPEMCPNEVHELQQMGSVVEHLSDEPSGPLSAAFNVQALYIDPLNDPYTLAGLGTVALEILRQVKDDQQLEGIFCSARAGGALEAIGLSVKQFAPHVKVIGVDVLPSVELSKLYGFPIDLPNAECNTHIPNALKTGQDNLPVISHDHLDRTLTTEISRVNPHVVDHVIMVKACEIQSAIRDTFQETRGIVDLNGALAVAGMMRFASTTGSLDVKERAKSLVAVISSADVVFDNIKEFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W6QAZ5</accession>
    <name>W6QAZ5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD(P)-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S02g003368</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM33216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QAZ5"/>
    <dbReference type="STRING" id="1365484.W6QAZ5"/>
    <dbReference type="OMA" id="EWGYEMA"/>
    <dbReference type="OrthoDB" id="2130169at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051783">
        <property type="entry name" value="NAD(P)-dependent_oxidoreduct"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079:SF6">
        <property type="entry name" value="NAD(P)-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079">
        <property type="entry name" value="PROTEIN YEEZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="1">
        <location>
            <begin position="11"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM33216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="341" mass="37292" checksum="181903E7AC19691F" modified="2014-04-16" version="1">MPASVFLLGPGFVGGEIIDFLLISNYNVTTLVRHESAVADYANLGVKTVVGNLDDTSVIKDQVAVNDIVFYIATADHLSSVQAIIDGIRQRAAQGLQTIYIHNSGATLLSDNAQGEYRSDIVFDDEQPDEIHALPDSAPHRLINLVIVGAAQELASYAKIAIMIPPLIYGMTSREHRLSIQLPTLIRYSIKHGYAGQIGKGLAVWSQIHVRDLARGYMILLHWIESAPIAEIALNPYFFCENGQELSWGECAAAIGHTLRKTGCITKSTPKPIPKENWDDLFGEYSGMVLGSNARIRANRLRKLGWTPLETDTFASLAEDEIPIIAKETGEFTGYASVVVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W6QBB9</accession>
    <name>W6QBB9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Dihydroxy-acid/6-phosphogluconate dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PROQFM164_S03g000035</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IlvD/Edd family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QBB9"/>
    <dbReference type="STRING" id="1365484.W6QBB9"/>
    <dbReference type="OMA" id="FDFAIMK"/>
    <dbReference type="OrthoDB" id="3851628at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016836">
        <property type="term" value="F:hydro-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.80">
        <property type="entry name" value="IlvD/EDD C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042096">
        <property type="entry name" value="Dihydro-acid_dehy_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020558">
        <property type="entry name" value="DiOHA_6PGluconate_deHydtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056740">
        <property type="entry name" value="ILV_EDD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000581">
        <property type="entry name" value="ILV_EDD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037237">
        <property type="entry name" value="IlvD/EDD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052352">
        <property type="entry name" value="Sugar_Degrad_Dehydratases"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004784">
        <property type="entry name" value="PRK06131.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009560">
        <property type="entry name" value="PRK13017.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43183:SF1">
        <property type="entry name" value="HYPOTHETICAL DIHYDROXY-ACID DEHYDRATASE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43183">
        <property type="entry name" value="HYPOTHETICAL DIHYDROXYACID DEHYDRATASE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24877">
        <property type="entry name" value="ILV_EDD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00920">
        <property type="entry name" value="ILVD_EDD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143975">
        <property type="entry name" value="IlvD/EDD N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00886">
        <property type="entry name" value="ILVD_EDD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dihydroxy-acid/6-phosphogluconate dehydratase N-terminal" evidence="7">
        <location>
            <begin position="102"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="Dihydroxy-acid/6-phosphogluconate dehydratase C-terminal" evidence="8">
        <location>
            <begin position="426"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="25"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF24877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM33311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="653" mass="71455" checksum="36A8071F10E4F74D" modified="2014-04-16" version="1">MACSDKKSCEGCSCSNDAQPQAINIEDCLSELQALRRRNQELEMRMGVKSQADNAQVPVKQPGRTLRSSAWFDCRTNPGMTAVYMERYFNYGITKEELMSGKPMIGIAQTGSDIAPCNRHHIELSKRVREGIRTAGGIPFEFPTHPIQETSRRPTATLDRNLAYLGLVEILTGYFLDGVVLLTGCDKTTPACLMAAATMNIPAICMNVGPMLNGYSKEALTGAGTVLWHGRELYATGDIDENEFMDYIARGTPSVGHCNTMGTASTMNALAESLGMALPGSAAIPAAYRHRAQCAYETGKRIVEMVEADRKPCDIMTREAFENAIVANAAIGGSTNAPIHINAIAQHTGVEVSMDDWDTIGSTIPLLLNMQPSGEYLGEEYYRAGGLPAIMAELLDQGKLNGDVLTCNGKTIAENVRGKHTWDRRVIKPYDDPLMKDAGFAHLKGNLFDSAIMKTCVISPAFRKRYLSNPDDLEAFEGSVVVFDGPEDYEHRLENTPYIDEKTILVMRGVGPIGYPGAAEVVNMHPPARLLKEGIDGLFCIGDGRQSGTSGSPSILNASPEAAAGGNLAILKDGDRLRIDLRKRRVDMLITDDEIEQRRKALGTKGYPIVPSGTPWQEIFRQETDQLSHGMVLRKAVKYQRLAQEGQPLRHNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W6QBH6</accession>
    <name>W6QBH6_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">PUA-like domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S01g000841</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QBH6"/>
    <dbReference type="OMA" id="RKKNHEY"/>
    <dbReference type="OrthoDB" id="2149705at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM27032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="160" mass="18193" checksum="75A1533E97E5128D" modified="2014-04-16" version="1">MAKSSSDIFMSIKPEHMGNIASGAKNHEYRGYLLPQKVHRIWFYTTLPVKQIAYVARISPGKIPGEVPEDGGIGNTEFNAGTKKSKYGYEIIKLWMLKHPISLEKAILEGFLKGAPQKYCWVPVSLLRRYPLDKHVQLISNTPELSAEEKKKDHENKLEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W6QBV8</accession>
    <name>W6QBV8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nicotinamide N-methyltransferase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S03g000265</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OMA" id="RARWCIV"/>
    <dbReference type="OrthoDB" id="2106152at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF104">
        <property type="entry name" value="N-METHYLTRANSFERASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17750)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM33541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="339" mass="37652" checksum="8A6E2539B90FDD2C" modified="2014-04-16" version="1">MLHSRLRPLPRHHHPSTPTTSAPAPEFQNEDADCEFDESPEDLFGTFLPHLFPDDAPSFHGDPGQHLLYSSPRYGDLNIMVPSYPSSSQQRPEADSSVNQVDEGRRLFAHFLWSAAMVVAGAVEEADTPTAPGETETEAQRENRELWRIKGESVLELGAGAALPSVVCALANASRVVATDHPSSPALSGAIAFNVEYNLARRSPTVVKAVSVYPHQWGLLDDSFSTANKGAFTRIVAADCYWMRAQHENLVRTMQWFLSPGGKVWVVSGFHTGRAIVAGFFETALENGFVIERIYERDLIARSEDDGEIRREWAPIREGEGTENQRRWCVIAVLKRRGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W6QCP1</accession>
    <name>W6QCP1_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S03</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S03g000550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QCP1"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM33826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="61" mass="6709" checksum="B7B481DBE3DD586B" modified="2014-04-16" version="1">MQSIRVHAAPPSATTYSQPNPTASNQLLIHIKSTTIICSMLTWPDEYTEFTPSQSTTSQAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W6QCY2</accession>
    <name>W6QCY2_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g001273</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QCY2"/>
    <dbReference type="STRING" id="1365484.W6QCY2"/>
    <dbReference type="OMA" id="HNRHLNM"/>
    <dbReference type="OrthoDB" id="5395390at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="577"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="660"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="603"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="664"/>
            <end position="681"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM27462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="681" mass="77427" checksum="8B9258F46D520058" modified="2014-04-16" version="1">MAPPSSSRSRSTRPTRSSRTKVQTYHEESSSDDESEGLRSSRRASLSLRSRMPKSYREDSTDDSFDFDGAVEDQESEASVSAPIDTPNPNTESVPTRPSKPKRPQRAATTSKPKQTKRSKPTSQVGRALHKRVKADEDDPIFLGSGVIPPWQTLPYQILLDIFLRASYPLLDESRSARNDSVKWLVNVALLCRSFHEPALAALYHCPPLLPAYKSHVLLSLLARPQESLSMNYSSKIKQLHVEVEPVLLYKSGPYGYLDLAQLIEKTPRLHTVRLYHRDDYTVGIPPWHIAQSKWTYPDAIFSAIETRGITLRNWDWNSRFLETDELVRLMVRMHSLRAFQGLRQLKLLHFDNSNEETSAAKEAALLEALDMLPELQRLDFIESSLVSGEILANLPNTLRSLTLNNCDRLWSSDLTAYLSLHGTNLRELSLSHNRHLNMSFIQTLAQCCESLEVFKMDLSMHDASSYHDVEPHFEDLLVETEVPTWPVKLQEIELTQLRKWDDATAEVFFTSLVNAAPQLRDLRRLVISAILKIGWRDRATFRERWIGMLEKVFLRHSMPPDPNLRSLQKRSLKPTTFITANDPDELGVGVDDPRPSTADGGPSSSSKRQSTRLAHQKFNIIDDAASSSSLVQPETRKIQGMCDIVNIRIDNQRPTELQFNENDFLDDELSGDEDWAGDDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W6QDE5</accession>
    <name>W6QDE5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Thioredoxin-like fold</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PROQFM164_S01g001433</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QDE5"/>
    <dbReference type="STRING" id="1365484.W6QDE5"/>
    <dbReference type="OMA" id="IFVYFYD"/>
    <dbReference type="OrthoDB" id="72053at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd02961">
        <property type="entry name" value="PDI_a_family"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052250">
        <property type="entry name" value="PDI_TMX3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46426">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE TMX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46426:SF1">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE TMX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004881488" evidence="6">
        <location>
            <begin position="21"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="660"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="7">
        <location>
            <begin position="49"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="7">
        <location>
            <begin position="232"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM27622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="720" mass="80646" checksum="F4FD389F4C4CD1AA" modified="2014-04-16" version="1">MKPSWLGWSLLSLLVAPALGTPSDASDQQSGNTLVKRASRGVDTDKPTIFNGIEVPPLTELTPENFEEVTKDGYWMIKHYSPSCPHCRIAAPLYQTLYEYYYTSNPLFLSGLKPDELASLDSFTGYYNLHFGSINCQAFGDFCKKLNVEFYPAWAFYDMGVQNEPPARAKTMSDIAAMIEAKLETIKPGTRPSQGIQIPKAGAESMEMTAKPAVVKPGAKTAVEKQSIETAELEGVSAESVKAKLQGRPANPQGVSIPLTAESFQSLVTTTHDPWIIKFYVPWCHHCQALAPNWNSMAKEMKDTLNVGEVNCDLEKRLCEDARVNAYPTIYFFRGGERVEYTGLRGLGDLIAYTNKAVGVGSSIQDVDSTTFKKLEETEEVLFLYLYDHATTSEDFEAMNRLTLSLVGHARIVKSDSAPLSERFKISTWPRLLVVRDGRPNYYNALAPKDMRDFRQILSWMQTVWLPIVPELTASNAQEIMDGKFVVLGLLSRRRSDDFKQSKRELKEAALEWMDKQVQLFRLERAELRDSKQLRIEEADDRNDQRALRAAKNMRITIREDDKKQVAFAWVDGDFWERWLRTTYGIDVETSDRVIINDQDNRRYWDTASSGAPIMASRTSILETIPLVIASPSKLSPKSTIGTFESIFFFARSLLGSHPILFFIILGAVVAVATIFGRGRLRRSAARGGIIGNTATNNGGFFHLDGKEGFLNGGSTDKVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2024-10-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>W6QDF2</accession>
    <name>W6QDF2_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S02g002365</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QDF2"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM32214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="41" mass="4813" checksum="A938EBA0489B6F94" modified="2014-04-16" version="1">MWREAKTILYRSGTPRSQDPVPRHMLNATVANGRARTWQKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W6QDP1</accession>
    <name>W6QDP1_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PROQFM164_S03g001535</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QDP1"/>
    <dbReference type="OMA" id="LPMSFNV"/>
    <dbReference type="OrthoDB" id="10262656at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504:SF16">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G13970)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="129"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="172"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="201"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="227"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="260"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="313"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="422"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="479"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="513"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="545"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="619"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="374"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="388"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM34808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="655" mass="71589" checksum="2AE6F17B9C13DFE2" modified="2014-04-16" version="1">MTRTGNHKTNNARHARTTSWSSGFHFTQGTGEPENTTGRRRRESNTSLASVEEYSSHDSLDSPVFDDNMLRNTSMDLNGDRKAQHVRGRSISHGLPQVLTVQENELPTVSAPARPALVTWMSLPRKGQLALLGLCRVFDFLQIASLQAYMFYQLKSFDPNLSDSDVATQAGILQGAFTAAQFATAIPWGRVADAEWGGRKFVLLVGLIGTAMSCLGVAYSTSFAQAVFWRSFGGGINGTVGIIRTMIAENVKEKKYHSRAFLILPIGFNIASLFGPVMGGMLADPVKSYPRLFGPNSSFGGANGVQWLETYPYALPMFANFCFLSSTAALVAYGLEETLASCKGKPGLGAFAKKMFARGVRRVVPSSSSLYTRLPHGDYEEDGPLLDRPTDRSESYELEEKAHKPARLQRALPFRRIWTKNVLCTLGAQAFFDFQMGAFNNLWLLFLSTPRYDSNDPASPARSLPFAFTGGLGMLPQSVGFATAILGVIGMVLQFTIYPTINGRLGAAKSYQYFLALFPIAYFIAPYISLAPSTTPPPGQANGPWVWFWIIIVLFFQVTARTFTLPTSIILLNNCSPHPSVLGTIHGIGQSVSSAFRTIGPIFSGAWYGYGLDIGMIGFAWWMIALVSVFGCLAAIFVYEGSGHEILLPGEEEDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>W6QDV3</accession>
    <name>W6QDV3_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Tyrosine-protein kinase, catalytic domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PROQFM164_S02g002510</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QDV3"/>
    <dbReference type="STRING" id="1365484.W6QDV3"/>
    <dbReference type="OMA" id="MIAKCLM"/>
    <dbReference type="OrthoDB" id="10252354at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004712">
        <property type="term" value="F:protein serine/threonine/tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000165">
        <property type="term" value="P:MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06620">
        <property type="entry name" value="PKc_Byr1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000253">
        <property type="entry name" value="MAP kinase kinase Ste7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000261">
        <property type="entry name" value="MAP kinase kinase Ste7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049613">
        <property type="entry name" value="Byr1-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050915">
        <property type="entry name" value="MAP_kinase_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47448">
        <property type="entry name" value="DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE DSOR1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47448:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE STE7 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="62"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="16"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="355"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="33"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="370"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="393"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="422"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="493"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="520"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="534"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDM32359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="544" mass="59421" checksum="69A9B307701E8C44" modified="2014-04-16" version="1">MTDQFKARTLKRKNVKGLALNAAPKPADGDGQTGSAGNSELSNTDTLEIGLEFRLDLRSEDLVTLKELGAGNGGTVSKVMHASTKVVMARKIIRVEAKENVRKQILRELRVGHDCNCPNIVTFYGAFQNEARDIVLCMEYMDLGSLDRVSKDFGPVRVDVLGKITESVLAGLVYLYETHRIMHRDIKPSNILLNSRGNIKLCDFGVATETVNSIADTFVGTSTYMAPERIQGGAYTVRSDVWSVGLTVMELAVGKFPFDHSDSGAGNRASTGPMGILDLLQQIVHETAPKLPKSDAFPPILHDFVGKCLLKKSEERPTPRELYDKDAFLQAAKRTPVNLEGWAMSMMDQEKRKSYLGPPISTQLSREASKPTPKSSPAAAPISGTIGKPPLVNKQTRTPQQSPFPSNPASGEIPLKIANEFPSSYRHYPQSQPQPQYYSSSSSRTTRSPPPPSLEHLSLEANDEDSRYGRRAMRQQLNEPVSAIDAPSRPFMSPRSASSNNSNPRTNLHSTAMPIRTAPPNGPPPPLPVPSGGNWRTQPGSTAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W6QE93</accession>
    <name>W6QE93_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Mg2+ transporter protein, CorA-like/Zinc transport protein ZntB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PROQFM164_S03g001785</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM35058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QE93"/>
    <dbReference type="STRING" id="1365484.W6QE93"/>
    <dbReference type="OMA" id="QECNENE"/>
    <dbReference type="OrthoDB" id="5207033at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="394"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="435"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="22"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM35058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="513" mass="58660" checksum="557A3E395244E47F" modified="2014-04-16" version="1">MSVNHSTNISYWRWIEPLGSETTASPPQPSLPGDESLPKPQELSRTELLQKDFLRKPGIHVIFMPKVEEGILKMAGSADLCRQLTEKFFLPNFFFERLGWNANGLFGSTVNFLQNDSETSYGTFSRFLSKRVKGKGAERTLNPGNSSNTNPLSTPAPDFEYAWHYMAFCTLWRSSLINPTGDSGQVRTDGSTDETNVLLCFDLDDDITLRLRRLLHKTDFRNWNNEPFLMLKYALNIVIEQCEDDLWSFQKPVRDIEKGRGQDLFMKTGSFDNDETFEFLVKRYSRLHELSRHVIHISESMDATSNNLGAIVRDHGVWIQSTFPSSAATTQLSKALLLYQNMITNLNFRAKAFVGRMDNEIKCASNFVTVANSNISKGILKQTRNEGKVLSDTVSALTLLFLPGTFISGFFGMNFFTLDENEKTQTLQWKTHPKIWIFFVCTIPITILGFFVFMLEFNLHAWIWRMQALIGGIFCRSRTSENIDSDNLGSLERSIGLPWKFWLSRRTTLRSTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W6QFE7</accession>
    <name>W6QFE7_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="8">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PROQFM164_S01g002103</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QFE7"/>
    <dbReference type="OrthoDB" id="6339427at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF26">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="85"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM28292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="120" mass="12832" checksum="505EBCAC16B3B0AC" modified="2014-04-16" version="1">MTTVAQKKKPYFGLTGGWLTFWITVACATDMTLFGYDQGVFIHDLVGPTKTTMLSTVTAIYDIGCFFGALVAFTIGEHLGRKKAILLGTTIMAVGGILQASSFSLAQMFVGRIVLGLGNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W6QG76</accession>
    <name>W6QG76_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Succinate dehydrogenase assembly factor 1 homolog A, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">sdhaf1A</name>
        <name evidence="6" type="ORF">PROQFM164_S03g001698</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the complex I LYR family. SDHAF1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QG76"/>
    <dbReference type="STRING" id="1365484.W6QG76"/>
    <dbReference type="OMA" id="VEMYSSP"/>
    <dbReference type="OrthoDB" id="273010at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034553">
        <property type="term" value="P:mitochondrial respiratory chain complex II assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20268">
        <property type="entry name" value="Complex1_LYR_SDHAF1_LYRM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008011">
        <property type="entry name" value="Complex1_LYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045295">
        <property type="entry name" value="Complex1_LYR_SDHAF1_LYRM8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13675">
        <property type="entry name" value="LYR MOTIF-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13675:SF1">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE ASSEMBLY FACTOR 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05347">
        <property type="entry name" value="Complex1_LYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Complex 1 LYR protein" evidence="5">
        <location>
            <begin position="9"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDM34971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="78" mass="9450" checksum="41DF016F2D3F5F4B" modified="2014-04-16" version="1">MARFSGLQRDVLSLYRKCLREIRNKPEDSRINFRNYARAEFQKYIAVNKKDFNTVEYLLRKGHRQLELYATPGIRNIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W6QG81</accession>
    <name>W6QG81_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Probable transposable element</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S01g002463</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QG81"/>
    <dbReference type="STRING" id="1365484.W6QG81"/>
    <dbReference type="OMA" id="NKCRHAK"/>
    <dbReference type="OrthoDB" id="4354814at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="199"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="179"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="206"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM28652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="216" mass="24096" checksum="5605D6A5A1F0A197" modified="2014-04-16" version="1">MKMRTGINYINKLEFLEAYPSARIEAFKSETIKNSFSVAGLIPFSPNRVLSKLNIYLRTPTPPLSRGSDLSRNFTPKTPFNSKDLRRQALSIKALLRTQSRSLISPSKRALNQLIKGCELAMHSAILLAKENKDLRDENENKKQKRARSRRQIPAEEGLSVQEASEIIARLVEALEIPLHPPGGSTQSGLEPRPRAAPRCSGCGKTGHKINRCPDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W6QGN0</accession>
    <name>W6QGN0_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PROQFM164_S04g000869</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QGN0"/>
    <dbReference type="STRING" id="1365484.W6QGN0"/>
    <dbReference type="OMA" id="ALMTHNN"/>
    <dbReference type="OrthoDB" id="27483at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030289">
        <property type="term" value="C:protein phosphatase 4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072542">
        <property type="term" value="F:protein phosphatase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055236">
        <property type="entry name" value="EVH1_PP4R3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006887">
        <property type="entry name" value="P4R3-like_central_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051137">
        <property type="entry name" value="PP4R3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23318">
        <property type="entry name" value="ATP SYNTHASE GAMMA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23318:SF0">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 4 REGULATORY SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22972">
        <property type="entry name" value="EVH1_PP4R3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04802">
        <property type="entry name" value="PP4R3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PP4R3 EVH1-like" evidence="5">
        <location>
            <begin position="11"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="Serine/threonine-protein phosphatase 4 regulatory subunit 3-like central" evidence="4">
        <location>
            <begin position="140"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="654"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="721"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="808"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="859"/>
            <end position="868"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF22972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDM35988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="874" mass="99060" checksum="AD239808B239F9D6" modified="2014-04-16" version="1">MALELQPPDGRRRVKVYELRDNDWFDRGTGFCTGQILGEEPRIFVESEDVPNRVLLETRITKNEGYQKQQETLIVWTEQNGTDMALSFQEAEGCAVIWDFVNAVQQHLLTLTSADDALSDDLDNYQSIVLPTPELGNLPEIEQIVRAASMTQGGRDALSKYIIRDEYIAKLVPLVTMAEDLESLIDLHRLCNIMKSLILLNDNTIIETVVADHVILGVVGALEYDPEFPTHKANHRQYLADKSRYKEVVPIKDPIIRRKIRSTWRLQYLKDVVLARILDDPTFSVLNSLIFFNQMEIVNHIQGNGPFLRDLFQVFDPRNPDQRRKDDAVQFLHQCASIAKNLQAPSRAQLFANFINHGLFAVIAFAIKHLNPAMRTTGIDILVILLEHDPVMMRGYMLKAVNEKKTPLTDTLIDLLHVEADLGVKNQLADAIKVLLDPQIPMQDPLGRAGPDYFKLRTNSLLSDAFVQQHFDESSKRLFQPLKQLANRTALNDLTFQEVTLYSHLVEILTFFVRQHLFRTRNSIQSESLAPRVAQLLRAPQKHLKLVALKFFRTLISLQDTFYQALMTHNNTFELILDIVYETMPRDNLLNSACLELFEFIRRENIKPFILHVVEKYREKLENIIYVDTFQSLILRYDQMQGYGAEADATLFSQDESNAPRRIPLNGQRWQGAREMDPAEEDYFNTSDDEDEMKWAQNRVATADEPPSGSASAVVKPLVDYPDDDEEDIMDTKPEGAGQQPVVGPTETSTEVPASPPTQNPPERLAEKRRREEEDDDELSKLTAGPKRRSSTSSNSGAFNMNRKKSLSAGSLTDKNASPGVLNNVTSAAPKRIAINIGSTAKPPISETDTTRTEVTSEIYEKENRDDSQGNEGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2024-10-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>W6QH17</accession>
    <name>W6QH17_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S04</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S04g000611</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QH17"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM35730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="31" mass="3770" checksum="EE33811D58A5C336" modified="2014-04-16" version="1">MKRVNERKPNCKCSVVSRYSSRESLCEAWWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W6QH98</accession>
    <name>W6QH98_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S04</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S04g000666</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QH98"/>
    <dbReference type="STRING" id="1365484.W6QH98"/>
    <dbReference type="OrthoDB" id="5427350at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053143">
        <property type="entry name" value="Arylsulfate_ST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039535">
        <property type="entry name" value="ASST-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011048">
        <property type="entry name" value="Haem_d1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35340:SF5">
        <property type="entry name" value="ASST-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35340">
        <property type="entry name" value="PQQ ENZYME REPEAT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14269">
        <property type="entry name" value="Arylsulfotran_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51004">
        <property type="entry name" value="C-terminal (heme d1) domain of cytochrome cd1-nitrite reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004881619" evidence="1">
        <location>
            <begin position="18"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM35785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="504" mass="55790" checksum="64CAAF6A1673D461" modified="2014-04-16" version="1">MFLKPVALLLVICESLADIPPLYRSRPYDLGAFDRWPHQLYHSSNAIGPILNIHDKSALCYNESTYTVVPYWGKQVNIPGVMLLDTKGYLVWHTTGYVTADIQSFQGEDYVVSLSEDSTYYALINSRYEEAYQIRSGNGWQLDAHELTLTPSGTALLVINGVFPVNQTAFEAPPEVEFIFDAGFQEIEVQTGEVLFEWRASDHYRFEEYYHFQPGDGKTEKTAPDLFHVNSIEKDDLGNYLISCRMMSSVVYVDGQTGAVIWKLGGKANMFKDLSGGAATDFNGQHHARFHENGRIVSIFDNGNCPGRPVTGPTRGLTVVLDTEKMTVQLQHEYISPNSVLTENSGSMQILDSGNVILGFGPNANWAEYASNGSLLCNVHIGPETFFNSGEIRTYRISKSPWIGHPQTVPEIAVDDGRVYVSWNGATEVATWSLDGTDIEGGGGASTFLGKFPKDGFETEISVPTNQTGRYFFVSALNRAGQVLGSTSTVHWPRPRQGIVYQGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W6QHR3</accession>
    <name>W6QHR3_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">S-crystallin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S04g000417</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QHR3"/>
    <dbReference type="STRING" id="1365484.W6QHR3"/>
    <dbReference type="OMA" id="PDADIHP"/>
    <dbReference type="OrthoDB" id="4951845at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00570">
        <property type="entry name" value="GST_N_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050983">
        <property type="entry name" value="GST_Omega/HSP26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43968">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43968:SF13">
        <property type="entry name" value="GLUTATHIONE TRANSFERASE OMEGA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13410">
        <property type="entry name" value="GST_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="1">
        <location>
            <begin position="28"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="2">
        <location>
            <begin position="117"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM35536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="282" mass="32127" checksum="8108B663721A3D35" modified="2014-04-16" version="1">MSAHPDSNLYPEASGPAKALVDKHRAEQPLKLYAGWFCPFVQRVWLALEEKKIPYEYIEVNPYNKPDSLLTLNPRGLVPTLSTPADPHPRPLYESTVILEYLEEAYPDHQPRFLPDDAYERARARIWIDYVTSRIIPSFHRFLQYQPADGTGQNADVGLDQARQEFLNHLKAWTKEMHSEGPFFLGEDISLPDLVLAPWAVRLWVLDEFKSGGLGIPREGEGGADEGVWSRWRTWLAAVESRRSIKETTSDLAHYLPIYKRYADNTAQSELAKATRAGRGVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W6QIS0</accession>
    <name>W6QIS0_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S05g000546</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QIS0"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM36713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="47" mass="5267" checksum="CB8222C45A11FB93" modified="2014-04-16" version="1">MPFPVLIIVRSLDLHSPGGCSTELQVIAWRLGKLGPIAGRERHFVIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2024-10-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>W6QJ17</accession>
    <name>W6QJ17_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S04</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S04g000892</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM36011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QJ17"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM36011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="49" mass="5906" checksum="7AE6B3C993B4BBFE" modified="2014-04-16" version="1">MSRQIWPGEGKMEYLRRPITPWFVTFRKETSNFQVPAIICVKLEPLVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W6QJG1</accession>
    <name>W6QJG1_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S05g000393</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QJG1"/>
    <dbReference type="OrthoDB" id="10428079at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM36560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="56" mass="6024" checksum="F0FF3A1334B17C1F" modified="2014-04-16" version="1">MLETELCAGSGNEATVDNGEKSTGLRKEVIRLSSMPQIGQQSGGRSSKSWLSKNIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>W6QJK3</accession>
    <name>W6QJK3_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">Isocitrate lyase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">icl1</name>
        <name evidence="14" type="ORF">PROQFM164_S05g000826</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = pyruvate + succinate</text>
            <dbReference type="Rhea" id="RHEA:16809"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57429"/>
            <dbReference type="EC" id="4.1.3.30"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>D-threo-isocitrate = glyoxylate + succinate</text>
            <dbReference type="Rhea" id="RHEA:13245"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
            <dbReference type="EC" id="4.1.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="13">Can also use Mn(2+) ion.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; glyoxylate cycle; (S)-malate from isocitrate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QJK3"/>
    <dbReference type="STRING" id="1365484.W6QJK3"/>
    <dbReference type="OMA" id="YVSGWQV"/>
    <dbReference type="OrthoDB" id="4078635at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004451">
        <property type="term" value="F:isocitrate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046421">
        <property type="term" value="F:methylisocitrate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006097">
        <property type="term" value="P:glyoxylate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.850:FF:000001">
        <property type="entry name" value="Isocitrate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006254">
        <property type="entry name" value="Isocitrate_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018523">
        <property type="entry name" value="Isocitrate_lyase_ph_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01346">
        <property type="entry name" value="isocit_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21631:SF3">
        <property type="entry name" value="BIFUNCTIONAL GLYOXYLATE CYCLE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21631">
        <property type="entry name" value="ISOCITRATE LYASE/MALATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00463">
        <property type="entry name" value="ICL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001362">
        <property type="entry name" value="Isocit_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00161">
        <property type="entry name" value="ISOCITRATE_LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0329">Glyoxylate bypass</keyword>
    <keyword evidence="8 10 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="206"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="97"/>
            <end position="99"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="207"/>
            <end position="208"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="423"/>
            <end position="427"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="457"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR001362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001362-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001362-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001362-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDM36993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="538" mass="60085" checksum="D1CBCAF177042CA0" modified="2014-04-16" version="1">MGLYEDEDRQFAAEVQAVQNWWKDSRWRYTKRPFTAEQIVAKRGNLKIEYPSNVQAKKLWRIVESNFEKKQASYTYGCLEPTMITQMCKFLDTIYVSGWQSSSTASSTDEPSPDLADYPMDTVPRKVNQLFLAQLFHDRKQREERVTTPAAQRGTVANVDYLRPIIADADTGHGGLTAIMKLTKLFIERGAAGIHIEDQAPGTKKCGHMAGKVLVPISEHINRLVAIRAQADIMGSDLLAIARTDSEAATLLTSTIDYRDHAFIVGSTNPTIKDLNDLMVAAEQAGKNGAQLQAIEDEWTAQAGLKLFNEAVIDTINAGSHANKKSLIDQYLAASKGKSNNESRAIAKNLTGVDIFWNWDSPRTREGFYRYKGGTQCAVNRAIAYAPFADLIWMESKLPDYKQAKEFADGVHAVWPEQKLAYNLSPSFNWKKAMPRDEQETYIKRLGELGYAWQFITLAGLHTTALISHQFSKAFSQHGMRAYGELVQEPEMEEGVDVVTHQKWSGANYVDNLLKMVSGGVSSTAAMGKGVTEDQFKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W6QJT9</accession>
    <name>W6QJT9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S05g000523</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QJT9"/>
    <dbReference type="OMA" id="RRNTAFW"/>
    <dbReference type="OrthoDB" id="4280783at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM36690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="141" mass="16204" checksum="9845D86845A36AE5" modified="2014-04-16" version="1">MAPISSSWQDKLLHECRIFIANLDAQAHILRCDPDSRGKERIGDVSQAVVDLSIRTDRIIDIAFGMIARAPDSEIIRRNTAFWCREDDGNYKFENVFLTMEHDLVHMTLALNRDPCQCKCNDIARRLEGIARKVSFNLNVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>W6QKC4</accession>
    <name>W6QKC4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Zn(2)-C6 fungal-type DNA-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PROQFM164_S05g000708</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QKC4"/>
    <dbReference type="OMA" id="RTMLACI"/>
    <dbReference type="OrthoDB" id="189997at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14723">
        <property type="entry name" value="ZIP_Ppr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052202">
        <property type="entry name" value="Yeast_MetPath_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782:SF12">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="576"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="10">
        <location>
            <begin position="17"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="100"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="189"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="100"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="201"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDM36875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="705" mass="79356" checksum="63B1771FC02FD584" modified="2014-04-16" version="1">MRHAPKRPRVGKRTILACIECKRKKLKCNGQTPKCNHCLKNQHECLVEDPATGLRRPRDYMQSLESRVVYLEALLRESRPDIPLNGDNQHELRDIESNTPFVPTTSAQAPEAPTSSQLQDSPGAYTSPSYMQEASSSSSIPKEHAGQVDHLSSEVALLCLNAAGGEPHYFGPSSAVLFSRIISATMGLKSEKSSSSPRTFEGSERSHPNARPDRVPGLPSPSVAANLSRAYFDNIHPQYPFLHRPTFCKWELDVCKSSQSVHNPAAGEVPLFFVLMVYATGSLVLNQSQHGAAAMYYSMALDYLPSVLALNNLESIQSILCCAVYSIRSPTGASLWKISGMAIRHCIELGYHRSAERYRKHVDPLTKEMSRRCFWVAYDIDRVAAFTLGRPMGIPDELIDAELPMDIEDENITPSGLLANPRATGNQVPTIMTGTLHVIKLRKLWAKFHATLYSPQLQYASTGSQFATVDTLRQELEEWHASAPTHLDYSSSHPLSVFASNEWFQIAYNHSILILYRSHITRILGERQGSGPNESNSTDFIEEEEDLQRAFENCSRCAREICVLYRRLYQKSSVQFTWGSLHILFLGGLTYLYCLWRSWRIRQQTKQSEILKTCMACTTVLVIIAERWNLATSYRDIFETLSEKTINMICGNDKLAGPAPPQSQWTAPYDNLLSPRDWSLGFDDLSMPQGSDWFIQEFLQQFPES</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W6QKD3</accession>
    <name>W6QKD3_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Rubredoxin-type fold</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PROQFM164_S02g000191</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QKD3"/>
    <dbReference type="STRING" id="1365484.W6QKD3"/>
    <dbReference type="OMA" id="STKCDCP"/>
    <dbReference type="OrthoDB" id="411372at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16464">
        <property type="entry name" value="RING-H2_Pirh2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039512">
        <property type="entry name" value="RCHY1_zinc-ribbon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008913">
        <property type="entry name" value="Znf_CHY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037274">
        <property type="entry name" value="Znf_CHY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017921">
        <property type="entry name" value="Znf_CTCHY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037275">
        <property type="entry name" value="Znf_CTCHY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21319:SF0">
        <property type="entry name" value="AND RING FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G08900)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21319">
        <property type="entry name" value="RING FINGER AND CHY ZINC FINGER DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05495">
        <property type="entry name" value="zf-CHY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14599">
        <property type="entry name" value="zinc_ribbon_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161219">
        <property type="entry name" value="CHY zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161245">
        <property type="entry name" value="Zinc hairpin stack"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51266">
        <property type="entry name" value="ZF_CHY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51270">
        <property type="entry name" value="ZF_CTCHY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CHY-type" evidence="7">
        <location>
            <begin position="309"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="CTCHY-type" evidence="8">
        <location>
            <begin position="378"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="445"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="15"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="126"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="234"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="289"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="639"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="684"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="128"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="254"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="293"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="692"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="716"/>
            <end position="728"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM30042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="737" mass="81236" checksum="D640CB5B872AE8F8" modified="2014-04-16" version="1">MSGFISSLLIQAGILSPLPPQPNSQPNDDEAKFHLNKPTYPSCDSEGHKLSPLLDQDHGQNSNCGDAGAGSLHSPPFFTTLPKEMDGRNSQSEGTRSVTHNTPGSIQNIDATAGASIDHTHEIDVTVQPDSSGNSLVSHPSEALSSSNEPQHASTISTSEPRQSLDNAFDPEGLAQSSLPADDGMGVLRSKIIAIRELELTNVEKARMVHGLMTEGYHSSRELRSAPGLGVFSTPSSPASLGLPTSPRTPRASEINTSRSGSPYSESDSLYETTFNLTAEDLQPTFVPKVETESPELETGDEEGDTEEQEETSLGCVHYHRNVKLECHTCKKWYTCRFCHDEVEDHSLVRRDTENMLCILCGYAQPAAQNCRRCGEQTAQYYCEICKLWDNDSKKSIYHCSDCGICRIGQGLGKDFFHCQTCSVCLPICIENTHRCIERSTQCDCPICGDYMFTSPETVVVMRCGHSIHHKCLSEYSKSSFRCPLCSKTITNMESTFRNLDRTIDSQPMPDEFKDTKGLIYCNDCGSKSVVKYHWLGLRCDLCESYNTAQIRILHGDMSTQAEEDFGQDLLPRPRSSSYTENDDPISSSLAALNVNNTSVPRSRLSAPMSTEPVRRFSSYNITRGRAVSPVVSNYFGLPTERESEKPSSIPFFGGPSRGENEDYGALNFLSKKLTYRYGLFGGETKSTESVLETENEEDDAESSDSAESDGSPGIGDDDEEEEEDQDEDHIQIFGHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W6QKK7</accession>
    <name>W6QKK7_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S05g000364</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QKK7"/>
    <dbReference type="OMA" id="LQRENCS"/>
    <dbReference type="OrthoDB" id="4321771at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="132"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM36531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="197" mass="22858" checksum="EB6B5414EF653E04" modified="2014-04-16" version="1">MIDSRFKTYDQEAKERALEASVAIPGASALTFKLNRCHGRKDSQAHHSITGSYTTSSPSEKIKCLHREGQWRCRGPSHYRTFTEVSRWGGSTITVLTNIGLDRQHPTQRVEGIITSIYAEMSRMQHEQILMVQFRDNMLRAYRNENASLEEQNRSLLEHVKSLQRENCSLELKHNKLMSEWAKERLQYPEQPDGKRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W6QL09</accession>
    <name>W6QL09_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Arylsulfotransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S05g000519</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QL09"/>
    <dbReference type="STRING" id="1365484.W6QL09"/>
    <dbReference type="OMA" id="FDIHEFN"/>
    <dbReference type="OrthoDB" id="5427350at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053143">
        <property type="entry name" value="Arylsulfate_ST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039535">
        <property type="entry name" value="ASST-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35340:SF8">
        <property type="entry name" value="ASST-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35340">
        <property type="entry name" value="PQQ ENZYME REPEAT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14269">
        <property type="entry name" value="Arylsulfotran_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004882142" description="Arylsulfotransferase" evidence="2">
        <location>
            <begin position="22"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="577"/>
            <end position="600"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM36686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="630" mass="71549" checksum="4CA96958B9A40F60" modified="2014-04-16" version="1">MLFLCLSWLSWLSWLCQTALAQYSSDDLMSFVTLPDIRAVKFNVQYQNRERVSPGYWFVAPYLHIGPDPPSTLYEQYQIGPHIYDGEGRLIWTGSQQFENRNVFDFKVVNSLGPDPHLSMVLQNSWDPAIDTGYGVILTNDYQVQRKLPLRKDLGSFDIHEFNILDDGKTALVTVYLSHEVTLEDFGRPTETTWLETGGYAEIDLNTAEVIQSWDSYKRIPLPETVHYNQFSPVEGHPGWDYVHINSVDKNEIGDYLISSRFANTIYLISCMDGNIMWRLGGKYSDFEQDFTFSKQHDAKFIESNGTHHIISFLNNASDEEFNEENISSSLFVELDTGARPMTARAIRRYNRPDGQLSRLRGNTQLLPNDNVFTCWSKEGYISEYAADGELLMTANFTSSRYSSYRGYKFEFTGRPTAPPDMVASVYGTDATNMVTTFWVSWNGATDVAWWRFYAQASEFHDPVLIGNTSRSDFETMYIARGYLDWVSVEAVDVNGTVLGRSEMHRSKSPDWKSVGYKGKSSPPIPADPSIVYQASDSAAEDKAVGDSGQMSSDAIETQTEKTTQVLNHTYNAIRSIGGVFSFVLLLCLFFAVMASYLVIRGWRLRVYQRVRTEDGGSEERAHLAPLHQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W6QL23</accession>
    <name>W6QL23_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Major facilitator superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PROQFM164_S03g001611</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QL23"/>
    <dbReference type="OMA" id="GKFNCCI"/>
    <dbReference type="OrthoDB" id="6499973at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17352">
        <property type="entry name" value="MFS_MCT_SLC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF250">
        <property type="entry name" value="MFS-TYPE TRANSPORTER AFUA_1G00970"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="174"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="276"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="306"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="331"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="360"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="391"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="5">
        <location>
            <begin position="14"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="206"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="207"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDM34884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="426" mass="45616" checksum="AECD0677BAA5892B" modified="2014-04-16" version="1">MSPKDSPPTEYTPRAWLVILGAFTCTFCTVGFMNSFGIFQEYYTKNQLSSTSTSTIAWIGAVSIFFLFAISVVAGAMLDIFGPTFMVYVGSFGCVFAIMMTSLCQEFYQFLLAQGILLGVSMAMVTWPMLALVGQYIKVKRAAAMGIVLAGSSLGGVIWPVAIDRLINKPKIGFPWTMRIVGFIMIPCFIFSCAVAKSPNTPAINLESRDSNQKSDEDTAEQKDKPQSHKAEAMALFRKPSLQLLCLAMFITYFGMFSPFFYTTSYAVEKGFSTSLAFYTVSIVNGASFFGRVLPGIVADKYGKFNCCIIATISAGVVALCWTKVTSVAGLVIWSAAYGFASGGILSLQQACAAQVATSTTLGLAIGTVSGATALSAMANVPISGALLEKYGYLSLSIFSGVSLLLGGLLLIAARLVQNRELRAIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W6QL40</accession>
    <name>W6QL40_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PROQFM164_S06g000525</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM164</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ustYa family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792020">
        <property type="protein sequence ID" value="CDM37563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QL40"/>
    <dbReference type="STRING" id="1365484.W6QL40"/>
    <dbReference type="OMA" id="HQSYYGA"/>
    <dbReference type="OrthoDB" id="3687641at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021765">
        <property type="entry name" value="UstYa-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365:SF11">
        <property type="entry name" value="TAT PATHWAY SIGNAL SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365">
        <property type="entry name" value="YALI0B05434P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11807">
        <property type="entry name" value="UstYa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="39"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00035112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDM37563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="254" mass="28335" checksum="C1713ED013188658" modified="2014-04-16" version="1">MLTAKAQEYKPLSNAKEDLDGEEEPQPHLRKPLNRQLTVAHIIFFVFSFITAFITGVLFTIYISNATTTHSYESGTPENISIAPHLPLRQIAGEFTYQSPFSKEPPLEGNVSEPTWDTLIPNGLGYFIPSTADTSRSKSSSVVIPSAFHQLHCLYLLRRAYYTTTPELQRFDFGRNRSVHVAHCFDYLAQAITCSADSTLEPAVDKEHGFLGGGFARRCWDFEYLKSVVESRRAFNASGFLAWGAGTEGKVELG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W6QL44</accession>
    <name>W6QL44_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">alpha-1,3-glucan synthase</fullName>
            <ecNumber evidence="2">2.4.1.183</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">ags1</name>
        <name evidence="11" type="ORF">PROQFM164_S02g000391</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>[(1-&gt;3)-alpha-D-glucosyl](n) + UDP-alpha-D-glucose = [(1-&gt;3)-alpha-D-glucosyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19749"/>
            <dbReference type="Rhea" id="RHEA-COMP:11150"/>
            <dbReference type="Rhea" id="RHEA-COMP:11151"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28100"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.4.1.183"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase group 1 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.183" evidence="2"/>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1365484.W6QL44"/>
    <dbReference type="OMA" id="AWRDHGC"/>
    <dbReference type="OrthoDB" id="512920at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047657">
        <property type="term" value="F:alpha-1,3-glucan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070600">
        <property type="term" value="P:fungal-type cell wall (1-&gt;3)-alpha-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11323">
        <property type="entry name" value="AmyAc_AGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03791">
        <property type="entry name" value="GT5_Glycogen_synthase_DULL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000058">
        <property type="entry name" value="Alpha-1,3-glucan synthase Ags1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000073">
        <property type="entry name" value="Alpha-1,3-glucan synthase Ags2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000052">
        <property type="entry name" value="Alpha-1,3-glucan synthase Ags2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058659">
        <property type="entry name" value="Mok11-13/Ags1-like_CBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058656">
        <property type="entry name" value="Mok11-13/Ags1-like_GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058657">
        <property type="entry name" value="Mok11-13/Ags1-like_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058658">
        <property type="entry name" value="Mok11-13/Ags1-like_Ig_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058655">
        <property type="entry name" value="Mok11-14/Ags1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058654">
        <property type="entry name" value="Mok11-14/Ags1-like_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013534">
        <property type="entry name" value="Starch_synth_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47182:SF7">
        <property type="entry name" value="ALPHA-1,3-GLUCAN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47182">
        <property type="entry name" value="CELL WALL ALPHA-1,3-GLUCAN SYNTHASE AGS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26127">
        <property type="entry name" value="12TM_Mok13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26122">
        <property type="entry name" value="CBM_Mok13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26108">
        <property type="entry name" value="GH_Mok13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13692">
        <property type="entry name" value="Glyco_trans_1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08323">
        <property type="entry name" value="Glyco_transf_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26114">
        <property type="entry name" value="Ig_2_Mok13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26111">
        <property type="entry name" value="Ig_Mok13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004881737" description="alpha-1,3-glucan synthase" evidence="9">
        <location>
            <begin position="20"/>
            <end position="2425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1076"/>
            <end position="1098"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2000"/>
            <end position="2022"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2034"/>
            <end position="2051"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2058"/>
            <end position="2076"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2096"/>
            <end position="2113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2125"/>
            <end position="2145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2175"/>
            <end position="2196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2216"/>
            <end position="2235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2247"/>
            <end position="2271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2280"/>
            <end position="2304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2324"/>
            <end position="2344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2351"/>
            <end position="2373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2397"/>
            <end position="2417"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="10">
        <location>
            <begin position="67"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1645"/>
            <end position="1701"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1719"/>
            <end position="1841"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1654"/>
            <end position="1678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1685"/>
            <end position="1701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1758"/>
            <end position="1775"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1792"/>
            <end position="1803"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDM30242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="2425" mass="271845" checksum="8FECB9214324B73D" modified="2014-04-16" version="1">MKWLLTSGLVSLLAKTVTAWPYDEAYLDYNLNENKTATNPADYWGTWPGHEGKYHPSPTNWRFPFYSLFLDRFVNGDPTNDNANGTTFEHDIEQRIRHGGDVAGLVETLDYLQGMGIKGLYIAGTSLLNQPWTSDGYGVLDTTILDAHYGTIQTWRDAITEIHKRGMYVLFDNTIATMGDLIGFEGHLNTSTPFSEKEYRTQWKTERQYRDFTIGAGDYNQTCDYPRFWFEDGYPVNESETSGLVGCYNSDFDQYGDIEAFGVWPDWKRQLAKFASVQDRLREWNPTVRERLIRHSCMIIQSLDIDGFRYDKGTQATVDALGDMSAAYRECARAVGKENFFITGEITGGNDFGAIYLGRGRQRNQWPESSAETIKLTNESSAQWFLREAGHEAIDSAAFHYTTYRALTRFLGMDGQLSAGYDAPDDWVLGWDWMVQSNDLVNANTGKFDPRHMFGVTNQDVFRWPSIANGTHRQLLGSFVTTLMLPGIPLLLWGEEQNFYILDATAENYIYGRQAMSPATAWRTHGCFNLQSSQYYKWPVLAAKKGCEDVTVAYDHRDPSHPLRNIMKQMYHLREQYPILNDGFYIGNLSKKTDYVYYPGSNGTATETGMWSIYRDINTNAQKYESKYQPVWLVYQNLNDTRTYTFDCNSDNVTKTLTAPFDSGTTVKNLFYPYDEIKLVDGVRKLGLNGSTELNGCAESLKMKAYEFRAYVPIAKHQYPRPMITKFTPGHDFPLRSTVAPNLPENVTVELYFSEEMNCTSVTGAITIDSSTETGKVPTLDSDTVKCTTISPLLQTNWTAEIPSVWKWTANLTGVYNGIHKLTVTNVTNKDTSSYTYAVDHFLFRVGQFDNPMVFTSANYSSSLLHKKDNGDLFIQHHAAGADKYRYSTNWASSFSNWKEYKGGNDTIERLPWSGTKKQEWDGEHVRVEYWSRLTGSSDYVQQGDADWDHPVTRRFPHAFFNGPYNQYGFDGGLDNRITLDTKTGVWSYHFTSEWPAVGQLNIWGINPDGKPDQTWVLGDIDNDTVLDRSPPSALSATLINITAAPAKGYLSHKIYFDDGTLHFWLDPVGPQSTQIAMFVLFWIIPFLTAVGCVYIFMKSFYKVKFNQVGVSEKQNIPLAIWNKIKTSSGHRDQSSNPLMRLANKSGFMQSTTALGGALASGKRRMVLIATMEYDIEDWAIKIKIGGLGVMAQLMGKTLGHQDLIWVVPCVGGVDYPVDQEAEPMEVTILGSPYQVQVQYHVLNNITYVLLDAPVFRQQSKSEPYPARMDDLDSAVYYSAWNQCIAEAIKRFPIDTYHINDYHGSLAPLYLLPRTIPVCLSLHNAEFQGLWPMRTLKEREEVCSVFNLNEEVARRYVQFGEVFNLLHAGASYLRVHQSGFGAVGVSKKYGKRSYARYPIFWGLHKIGNLPNPDPSDVGEWTKEPTKEQDITVDATYEAGRGELKRQAQEWAGLDQNPDADLLVFVGRWSMQKGVDLIADAMPAVIEARPNVQLICIGPVIDLYGKFAALKLDHMMKVYPGRVFSKPEFTALPPFIFSGAEFALIPSRDEPFGLVAVEFGRKGALGIGARVGGLGQMPGWWYNVESISTSHLLMQFKLAIEAALNSKTSVRAMMRARSAKQRFPVAQWVEDLEILQSTAIAVHNKVAKGNNNNNRPGTSSGVSTFSGALSPSPSMTQLGSPLASPGLNSPYTHSRDSSYSFNQMNNLAPQKKVSYSADTNLDDMEKPKSGLSRSLSLGVHSGPGHAGRRRAAKEAGISESDENGATDAEGEDSSDEDTARTVFGDDEYTLTPAQVEAGRRAQAAQRDRPQNLPSPSQESLHPRFMLPLESPGSPGTPPSADSLLLPPQPFGQSNRFSSASVLSLDSVVGNKTDFKLQKVDPFFTDSTGEYYRTFDKKLDALNGSNSESQLCIEEFLVKSEQQWFDRFRNARLGRTKSPTPSIRHSSRNTDTPDNMFYSDDLVSNINSNEENHLQDDEFLLGKDYVPPSGLKKWMQIKIGDWPVYSIFLALGQIIAANSYQITLLTGEVGQTADKLYGIATTYAIASMCWWLVYRYFKSVVCLSTPWFLYAFAFLLIGSAHWQDDSFSRGWIQNVGTGFYAAASASGSIFFASNFGDEGGAPVETWIFRACVIQGIQQAYVIALWYWGSTMTKASSEGLLSAESGIANSWKMSAICYPITVFLCFVGILLALGLPNYYRQKPGKVPSFYKSLFRRKIVAWNFVAVILQNFFLSAPYGRNWSFLWGSSHAHAWQIVILCIVFFGVIWCIFLFVVSKFSKRHSWFLPVFACGLGAPRFIQIWWAISGIGYYLPWAGSYTSGALVSRSLWLWLGVLDSIQGLGFGIILLQTLTRVHMCFALIASQVLGSIATICARAFGPNSVGPGPISPDMTKGAHSLANGWFWVALFCQLLICAGFLLFFRKEQLAKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W6QLI0</accession>
    <name>W6QLI0_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type DNA-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PROQFM164_S07g000046</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792021">
        <property type="protein sequence ID" value="CDM37698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QLI0"/>
    <dbReference type="STRING" id="1365484.W6QLI0"/>
    <dbReference type="OMA" id="ECPGYVQ"/>
    <dbReference type="OrthoDB" id="5418899at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF18">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="9"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="60"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM37698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="704" mass="78666" checksum="0B24C3A3CBB940E9" modified="2014-04-16" version="1">MPGVPSNKACERCKKRHLKCDETRPHCQRCTTAGVECPGYVQTRKFIDQGATVRRRYAPYQEPHSRPNSAFNSNKPKSSQVGPNEQTLQWNQPQEQDNPALHFQMDSRDDSMIVEMPGPSNRPEVAMGSIQQTTMHAPESPAISIHNSISGIEEGSESSRNTIYKSISPTAAAGGFPTFDNTYTPIPHKGPDYQRVISESSSHRSEKDEFQDIFSELMTGTEHEIAFLTRHYSEVIGPWLDLSDSQKFFTVHVPIRAISNLSVKYAIAALAAKHLARLKGVKASTGGMFTSPATTETYPNATQVDWFLKAANYYYLGASDLNNLTSDGYTTVSSSAILESPFEIVGRWISSRQTQATMKPASEDPNDMAIIRKTEELLASATLLTMYRLLDMPGDEWHMQLARIGPLFESLLSLHSASSALFSHGIRAAFWNFARQDYLGSYFTRSPTHFDPENLPLWRAAGISINDQKSFHIIRNGSTLSQEDQAANGLIWLVTKVINFLARSKQLQLAQWTGSPPAASPEGTTTNATQLPYPDTDTWLKISFEFQTWFENVPETFRSSVRIERPKDLSKTAEGSYLSFPEIFHGLTTCAVAMQHYHFGRIALLLNRPADVISAPSTAFDRLQGYREVTKEVEFRAREVSGIALGRPQGGVRIFMVPLLVAVGQCLENPEEHQIIVDLLRGVEADLGWTTEYAIRKLQDSWNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>W6QLJ0</accession>
    <name>W6QLJ0_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Protein SOF1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">SOF1</name>
        <name evidence="10" type="ORF">PROQFM164_S03g001811</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat DCAF13/WDSOF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM35084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QLJ0"/>
    <dbReference type="STRING" id="1365484.W6QLJ0"/>
    <dbReference type="OMA" id="EDHNAYI"/>
    <dbReference type="OrthoDB" id="10249065at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000657">
        <property type="entry name" value="U3 small nucleolar RNA associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000743">
        <property type="entry name" value="U3 small nucleolar RNA associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007287">
        <property type="entry name" value="Sof1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051733">
        <property type="entry name" value="WD_repeat_DCAF13/WDSOF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22851:SF0">
        <property type="entry name" value="DDB1- AND CUL4-ASSOCIATED FACTOR 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22851">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA U3 SNORNA ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04158">
        <property type="entry name" value="Sof1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 7" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="62"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="105"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="279"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="322"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="Sof1-like protein" evidence="9">
        <location>
            <begin position="355"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="421"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDM35084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="447" mass="50601" checksum="AA0B01DD801E764D" modified="2014-04-16" version="1">MKIKALSRSTASQQAPGSAVVRQSRNLDPTQHPFERAREYTRALNAIKMERMFAAPFLAQMGNGHVDGVYSMAKDPGSLERFASGSGDGVVKVWDLTTQGEVWNTQGHENMVKGLCWTPERKLLSCASDKTIKLWDPYNSSSEAPPMATYLGNSAFTSVTHHRSLPSFAAASGVISIYDLSRPSSTPSQTMHWPTNVDTITSVAFNQTETSILASTAMDRSVIMYDLRTSQPVHKTTLRLASNAISWNPMEAFNFAVANEDHNAYIFDMRKMDRALNVLKDHVAAVMDVDFSPTGEELVTASYDRTIRLWNRSTGHSRDIYHTKRMQRVFSATFTPDNRYVLTGSDDGNVRLWRAKASDRSGVKTARQRSKLEYDQALIQRYSHMPQIRRIKRQRHVPKPIKKAGEIKREELNAIKRREENVRKHTKKTNLAPRTHEREKMILASEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W6QLQ2</accession>
    <name>W6QLQ2_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S07g000086</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792021">
        <property type="protein sequence ID" value="CDM37738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QLQ2"/>
    <dbReference type="STRING" id="1365484.W6QLQ2"/>
    <dbReference type="OMA" id="GPMNVLV"/>
    <dbReference type="OrthoDB" id="4155914at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="265"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="564"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="589"/>
            <end position="599"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM37738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="680" mass="75964" checksum="7565CAA12FE2DCE7" modified="2014-04-16" version="1">MRNLFKSKSPSNRTSHHSMRSAEQLAHPAFTPPDPNAPNTESDRRLSQFEYSGSVQNQPQGLNRSQSQRQKPLRDRPTVNVTVPDDSRKKGRVERSVSVKGKPISQPTSPGTLHPETLDESDEFPPHLRHSYTENPSPVAPQSLAYQPKYQGQRAPRPSHPAHVQDNPEWSQKPVQPVQPLYTKLQRSNTDSTLDQYSRPSPTDIPESPRYTEHLHRGQAFSAQDPVLNTRPPSQQTHEPLSPLQSRYPDAMQSSAQASNQGFYPLDRQKSAGSPQQNRSRQGSVSNNMPDPGRSTPTKTHRREESGEVDVRALIQKHDELQAKYSKVKRYYFEKDAQVQHLQNTVAHQRMAVSRTVLDDNEYTSRFQRLDGAIKDLAFSVRKDWRSIPAWLNGMVTDDALSVGTKEMTPVGRAVISRWLVEEVFQRYFHPCLDPTFSVQLKSIEMNLRRQRPTSEEDRENASARLSYWRRTTFDGLGDSLVGPEAQERRVELVEHLIVELAAFIGSQLHEIALPGLEASVRMIIENSVNIIEKIPLEARDVCVDYFPPGISLAEQYMKVEGQLPALSHPPPPPSDPEQLEEPVAAEGDTSSGSTGAVESTSSAQKKSTKKSIFGALISRKHGGENSRSTPPPGPAEDKSEPAEVAPSAPRIRFAAFLAVEVRGKGPATVLIKSPVWLVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W6QLU3</accession>
    <name>W6QLU3_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S07g000121</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Cyclase 1 superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG792021">
        <property type="protein sequence ID" value="CDM37773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QLU3"/>
    <dbReference type="STRING" id="1365484.W6QLU3"/>
    <dbReference type="OMA" id="KLSEHCK"/>
    <dbReference type="OrthoDB" id="5396at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004061">
        <property type="term" value="F:arylformamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:L-tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.50">
        <property type="entry name" value="Putative cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007325">
        <property type="entry name" value="KFase/CYL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037175">
        <property type="entry name" value="KFase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34861">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34861:SF11">
        <property type="entry name" value="CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04199">
        <property type="entry name" value="Cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102198">
        <property type="entry name" value="Putative cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM37773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="325" mass="36179" checksum="D88FE8FC37477A4D" modified="2014-04-16" version="1">MTKATEDAMISFDSLPLDPTGPRGNAWGRFGQDDQLGTLNLLTPERVVEAAKEIKTGVRISLDWPLSMPSYPSFNRNPFKHELILRSPNCIHDDTLAFNSQGSTQWDGFRHYANQKSRQFYNGHTTEEIESSDIIGIHSICEHGGITGRGVLLDYAEWATTNSIPTSALKSETITVENLKRVVKDHNLNFQKGDILFIRSGFTAAYNKLDDQQRKDLALRSSPDFSGVEATECMVRWLWAHQFSAVAGDAPSFERAPIRGAHADPNFNLHEWVLAGWGTPIGEMFDLEKLSEHCKASGRYSFFLSSMPLKVIGGVASPPNAFAIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W6QME3</accession>
    <name>W6QME3_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S04</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S04g000235</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QME3"/>
    <dbReference type="STRING" id="1365484.W6QME3"/>
    <dbReference type="OrthoDB" id="5979581at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM35354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="95" mass="10930" checksum="ADCA31F8D40CEDA0" modified="2014-04-16" version="1">MTSRLTSRLNAFISASRIAYRSFQPTSRRSFVSLPVETLIDEETLPHYDPRQFYPVSIGEVFDDRYRVTGKLGYGAHSTSWLCHDIHSEAKAMPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W6QMQ1</accession>
    <name>W6QMQ1_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FAD-binding, type 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PROQFM164_S09g000074</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792023">
        <property type="protein sequence ID" value="CDM38158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QMQ1"/>
    <dbReference type="STRING" id="1365484.W6QMQ1"/>
    <dbReference type="OMA" id="THPQDHK"/>
    <dbReference type="OrthoDB" id="2151789at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF13">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004879955" evidence="5">
        <location>
            <begin position="23"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="6">
        <location>
            <begin position="56"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM38158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="497" mass="54418" checksum="FA83981A88E61029" modified="2014-04-16" version="1">MLSSNRWHVVALFLALVPRTMADICATLKAGGIDIEDRISLAYNTDLTEYWSAACGDLKPTCIAAPSSAAEMAQVIKNLNDVDTLFAIKSGGHNPNNGFSSIQDGLLVSTKNLDQVDYNPTDQTVVIGPGLSWEEAQKGLAGTGRAIVGGRMGGVGVGGYMLGGGMSFLSTQYGWAANNVKDFEVVLANGTIVHATETENADLFKSLKGGGNNFGVVTAYTVQTHPQDHKVWGGNYVYTSDKAADILTVVRNFTDEYPDDKAAIILTFERGLVVDLCILFLFYDGPEPPSGVFDGFTAIEHTSTAKTWDTYYDLLKNNDFFILKGQRYNIATETTPLPNKTVGAAPLQEYYEHFRDVTGSVLGVTGIIGTVSFQPMPKTFSQKAKDRGGDLLDIPSDQPYIILELDFSYGLSTDDSKVDAATVELYQGMDNLAQKNIDNGLLPDVYRPLFMNDAYYRQDYWGRISPESKALALETRKAYDPQEFFQKRTSGGWRLKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W6QMR2</accession>
    <name>W6QMR2_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="7">COP9 signalosome complex subunit 8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">csnH</name>
        <name evidence="7" type="ORF">PROQFM164_S02g001032</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QMR2"/>
    <dbReference type="STRING" id="1365484.W6QMR2"/>
    <dbReference type="OMA" id="LRAVWQT"/>
    <dbReference type="OrthoDB" id="5351233at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010387">
        <property type="term" value="P:COP9 signalosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000338">
        <property type="term" value="P:protein deneddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033205">
        <property type="entry name" value="COP9_CSN8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033464">
        <property type="entry name" value="CSN8_PSD8_EIF3K"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13339">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13339:SF0">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10075">
        <property type="entry name" value="CSN8_PSD8_EIF3K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0736">Signalosome</keyword>
    <feature type="domain" description="CSN8/PSMD8/EIF3K" evidence="6">
        <location>
            <begin position="56"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF10075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM30882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="221" mass="24613" checksum="3BF667A743262E24" modified="2014-04-16" version="1">MELPLLTTEHLSKLVASNAPPSQLFEALSRYELQACLISTRGDSANTGGSDSTLLSLFYSSFFLIHLLTDQVSEARALTKQIPEALLQQDPSLQNCLTLLRAVWQTQHGQVYQVLRGLPWPDVLQPLVRRYESFFQDKTLIAVSRSYEAIRLATAATHLGLDQNLAKEEDPNIISNFTKYGWTWDPESKLLYPKPIVVSLAEPQSSNGIHKAMAMLGTRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W6QMX7</accession>
    <name>W6QMX7_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Alpha N-terminal protein methyltransferase 1</fullName>
            <ecNumber evidence="5">2.1.1.244</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Translation associated element 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">X-Pro-Lys N-terminal protein methyltransferase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">TAE1</name>
        <name evidence="13" type="ORF">PROQFM164_S02g001137</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N-terminal L-alanyl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-methionine = N-terminal N,N,N-trimethyl-L-alanyl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:54712"/>
            <dbReference type="Rhea" id="RHEA-COMP:13785"/>
            <dbReference type="Rhea" id="RHEA-COMP:13971"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:138057"/>
            <dbReference type="ChEBI" id="CHEBI:138315"/>
            <dbReference type="EC" id="2.1.1.244"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N-terminal L-prolyl-L-prolyl-L-lysyl-[protein] + 2 S-adenosyl-L-methionine = N-terminal N,N-dimethyl-L-prolyl-L-prolyl-L-lysyl-[protein] + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:54736"/>
            <dbReference type="Rhea" id="RHEA-COMP:13787"/>
            <dbReference type="Rhea" id="RHEA-COMP:13974"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:138059"/>
            <dbReference type="ChEBI" id="CHEBI:138318"/>
            <dbReference type="EC" id="2.1.1.244"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>N-terminal L-seryl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-methionine = N-terminal N,N,N-trimethyl-L-seryl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:54724"/>
            <dbReference type="Rhea" id="RHEA-COMP:13789"/>
            <dbReference type="Rhea" id="RHEA-COMP:13973"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:138061"/>
            <dbReference type="ChEBI" id="CHEBI:138317"/>
            <dbReference type="EC" id="2.1.1.244"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. NTM1 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.244" evidence="5"/>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QMX7"/>
    <dbReference type="STRING" id="1365484.W6QMX7"/>
    <dbReference type="OMA" id="ETYYCFN"/>
    <dbReference type="OrthoDB" id="1298661at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071885">
        <property type="term" value="F:N-terminal protein N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000025">
        <property type="entry name" value="N-terminal Xaa-Pro-Lys N-methyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008576">
        <property type="entry name" value="MeTrfase_NTM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12753">
        <property type="entry name" value="AD-003 - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12753:SF0">
        <property type="entry name" value="ALPHA N-TERMINAL PROTEIN METHYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05891">
        <property type="entry name" value="Methyltransf_PK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016958">
        <property type="entry name" value="DUF858_MeTrfase_lik"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="12">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="123"/>
            <end position="124"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00043129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00082558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR016958-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDM30987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="236" mass="26335" checksum="59C2998334EA2528" modified="2014-04-16" version="1">MPESNVAADSKIDHAASLKYWNSVPATTASMLGEFPSVSRIDLQGSKTFLAKVRRLLPKVQSEGKLHRGVDCGAGVGRVTEGFLSHVCEVVDAVEPVAKFTQVMKDSQLKRDGVIGNIYTRGLQDWIPEKKYDLIWVQWCAGHLTDSQLIDSTVRCRKALTENGLMVFKENLSTHFSKEDMYDSEDSSVTRTDAKFRQVFEAAGMEVVKSELQKGFPPSFNLLPVQFYALRPKTTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W6QN23</accession>
    <name>W6QN23_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Peptidase M12B, ADAM/reprolysin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PROQFM164_S06g000312</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="HG792020">
        <property type="protein sequence ID" value="CDM37351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QN23"/>
    <dbReference type="STRING" id="1365484.W6QN23"/>
    <dbReference type="OMA" id="SHESAHT"/>
    <dbReference type="OrthoDB" id="5951731at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.70.10">
        <property type="entry name" value="Disintegrin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001762">
        <property type="entry name" value="Disintegrin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036436">
        <property type="entry name" value="Disintegrin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001590">
        <property type="entry name" value="Peptidase_M12B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11905">
        <property type="entry name" value="ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11905:SF222">
        <property type="entry name" value="ADAM FAMILY OF METALLOPROTEASE ADM-A (AFU_ORTHOLOGUE AFUA_6G14420)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13688">
        <property type="entry name" value="Reprolysin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50215">
        <property type="entry name" value="ADAM_MEPRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50214">
        <property type="entry name" value="DISINTEGRIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004879721" evidence="4">
        <location>
            <begin position="23"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="522"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12B" evidence="6">
        <location>
            <begin position="207"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="Disintegrin" evidence="5">
        <location>
            <begin position="438"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="483"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="354"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="353"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="357"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="363"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM37351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="570" mass="60723" checksum="65D022CC9520F0AC" modified="2014-04-16" version="1">MKKPTLSFTFLALHAWFVSILAVGCDPVSVHFIDPVLSPLNATKKFSITAGIETCNQTINFILENNDDLLSQDVQIRYPGLHGQANETGALSGAHVRFTKGTVWMQDPYSRSQDNVGWARLTVIQEGDSLLFDGAFTMMGSQYAIEFEMLDDGSTAIVAHEQESTLSPICSTSPETHLCKRQSWDPWSNEDLTSTIGSTYGCPNTRKIANVGIMTDCTYTAGFNSSDSAYRYILNMVNTASVVFENSFNISLAIQNLTISDSECPDNTSGTTAWNVPCSRGDLNTRLQDFSTWRSSVDDENAYWTLLTGCSGSAGEVGVSWVAALCNTGSGSGDSGATNVVARTQNEWQVFAHESAHTFGAVHDCDSSTCGSDSTQCCPLSSNTCDADGQYLMSPVSESGITRFSPCTIGNVCSRLGSGQVDGRCLVDSYTGNTTGTNEQCGNGIVETGETCDCGNGACSEQESRCCDSVTCQLRSGDGCDQTNNGGSGNTANTDNNGNTGGRISGNGQPSNDVSSWVQNHLPLVIGLSAGIGGALLLLILGCLIFSCRRSRRRPVVNNKPVAMPPPQYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>W6QPC8</accession>
    <name>W6QPC8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Zn(2)-C6 fungal-type DNA-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PROQFM164_S04g000845</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QPC8"/>
    <dbReference type="STRING" id="1365484.W6QPC8"/>
    <dbReference type="OMA" id="IHTLVIC"/>
    <dbReference type="OrthoDB" id="5121955at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052073">
        <property type="entry name" value="Amide_Lactam_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47171">
        <property type="entry name" value="FARA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47171:SF1">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="19"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="59"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="59"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="108"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM35964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="575" mass="65200" checksum="D15B78D5ACDD451F" modified="2014-04-16" version="1">MDIANREAEGPKQRRTRVACRRCNSKKIKCNSQEEVPCKGCVSTNTDCVPIESQRGRYIRKGPRARNAGKSHVPQNDKEIPPIARSSNFPTSGVDHLAESEIPLPPEDQTSSSFQRTLDASDQDSDCRFYLHIADQGVSSTPQPISSQKGTLFLGESFSLTYVVHDVLAPLLSTECAPNYRRRLHFPVDEGFDPSMRGQQNMVEAQTKLLHSRDLWFHPDQRALEQLLAIYFKWFHPAFPILEKSSFLQKYSENQLSLLLLNGVLMIAVTVCDEADLALLGLQDRYKARELFYKQARALYETDSDPDKINNVVASFLISFWWGGPNDQKDSWHWLGIAISSAQNLGMHRSTAKSHMSSHRVRIWRRIWWCLRIRDVLVSSSIGRPQHFSVYDCDVEMLSSHDLEGEFQNETEIHYVCQMARLSTIFGDIISSRYAAVKPDHPSQMKIQLEKELDDFRSQMPTILRYTGIDAEGKICLWSAMLLMAYNFGVILLCRPPHSNGLDMSQSWGNPFKASSAANEVTRVIEDILSLSMGRVCQIHTIPALFNSLAIHVFTICTSRAIGRELAENRARTCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W6QPG2</accession>
    <name>W6QPG2_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Major facilitator superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PROQFM164_S07g000229</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG792021">
        <property type="protein sequence ID" value="CDM37881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QPG2"/>
    <dbReference type="OMA" id="KALTWYL"/>
    <dbReference type="OrthoDB" id="4078873at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010106">
        <property type="term" value="P:cellular response to iron ion starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000302">
        <property type="entry name" value="MFS siderochrome iron transporter MirB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000284">
        <property type="entry name" value="Siderophore iron transporter mirB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF50">
        <property type="entry name" value="MFS SIDEROCHROME IRON TRANSPORTER MIRB (AFU_ORTHOLOGUE AFUA_3G03640)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0410">Iron transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="156"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="211"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="243"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="290"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="330"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="360"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="401"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="434"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="460"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="500"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="572"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="12">
        <location>
            <begin position="86"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="25"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CDM37881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="606" mass="67327" checksum="5D006D90872CFAD9" modified="2014-04-16" version="1">MTLRPLIQRARAVFRRMKVDSDDAASSSSVEVDRNTVEAEKSEGSISHPEDTLPNNGAELPGVPYEELQHGIQEVEAVAQTWSKVSLIFVFINMWFLYFTYAWISSIDGSLSTYVASSFQQHSLSGLPTAIADAFSAAVFLPVAKMMDTWGRAEGFLVMSICATVGLVLMASCNSFAVYCAANVFYYIGFGGMQFAVDVITADLSQLKNRALAYAFTSSPYIITAFAGPKVADLFYAHTGWRWAYGTFAIIFPVVAAPLFFVLKFNLTKAKKGNAVVIRENSGRSFLQSIWFWTLEFDLIGVFIFTAGLVLFELPFDIASEAPKGWGTNYIIAMIVVGFSMLFFFAFYERYIAPTPLLPYSFLTNRTVVGACLLDATYQLSNYCWNNYFSNFLQVVNDLTIAEAGYITNTFDVVSGILLFFVGWAIRKTGRFKWLLYISVPLYIFAQGLMIYFRRPGQSVGYQVMCQIFISIGGSIFIIVEQLSILAAVDHQHVATALALLNVVGTIGDSAGLTISMAIWNNTYKKALTWYLPDLKDLDMIYEDLETQLSYAPGTPMRTAIQKAYGYTQVRMLSAGVGVMALAFAWTIMIKNINLNKVAQVKGVVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W6QPP4</accession>
    <name>W6QPP4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S08g000017</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792022">
        <property type="protein sequence ID" value="CDM37966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QPP4"/>
    <dbReference type="STRING" id="1365484.W6QPP4"/>
    <dbReference type="OMA" id="WEITEIK"/>
    <dbReference type="OrthoDB" id="5402816at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM37966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="70" mass="7991" checksum="EAFBCFDC384957B3" modified="2014-04-16" version="1">MAAIHPSPARGIEVRDELVRRNWASREPGPILVFCIVFVVGVGILALIIQKVVKDRREERAKWEITEIKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W6QQ18</accession>
    <name>W6QQ18_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S15g000009</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792029">
        <property type="protein sequence ID" value="CDM38545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QQ18"/>
    <dbReference type="OrthoDB" id="4349275at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM38545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="77" mass="8620" checksum="2FD376CCD3AA3349" modified="2014-04-16" version="1">MFFLPRVKTLIGNLRRVRGHILDITSQAAVRAMTSYFRLSLIPRSEALPYSSHSTLSPLAILPPMLSLDPSFSVHNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W6QQP3</accession>
    <name>W6QQP3_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WD repeat protein 23</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S02g002018</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QQP3"/>
    <dbReference type="STRING" id="1365484.W6QQP3"/>
    <dbReference type="OMA" id="PANGHCQ"/>
    <dbReference type="OrthoDB" id="190105at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847:SF741">
        <property type="entry name" value="E3 UBIQUITIN LIGASE COMPLEX SCF SUBUNIT SCONB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="53"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="167"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="207"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="249"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="289"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM31867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="396" mass="43868" checksum="03D5CFE708C44B0E" modified="2014-04-16" version="1">MWKNTKPTHIAFQAHNRHVLTCLQFDADKIIVGSDNAKISVYDTKTGALRATLEGHEGGIWGLEYHGNTLVSVSTDRSVRVWDIAKAKCTHVFKGHTSTVRTVQLLLPVQIGQHPDGTPVMMPEQPLIISGSRDSTMRVWKLPQPGDEEYFPPAQSDEECPYLIHVLAGHQHSVRATAAHGDTLVSGSYDSTVRVWKVSTGESLHRLEGHRYKVYNVSLDHERNRCISGSMDNMVKIWSLDTGALLHNLEGHSSLVGLLDLKDDLLVSAAADSMLKVWNPANGHCQHTLSGHTSAVTSFQHDGQKVISGSDGEVKLWDIQTGVFERDLLTNLSGVWQVQFDAQRCVAAVQRGNLSYIEILDFGASPDSIPTGRLGERILVDELGHEIESRKRQRQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W6QRA5</accession>
    <name>W6QRA5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S14g000005</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792028">
        <property type="protein sequence ID" value="CDM38506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QRA5"/>
    <dbReference type="STRING" id="1365484.W6QRA5"/>
    <dbReference type="OMA" id="RDCVKSD"/>
    <dbReference type="OrthoDB" id="3556886at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM38506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="95" mass="10393" checksum="12ECD425454AA3D5" modified="2014-04-16" version="1">MSPRTAAAMIRMRLVIISLTITWLALASLSSAIVHFAVVLRDCVKSDLVTPTDSILDITFQNLMDNVVDGMVIAALVSALFSIFGLILVIYPKWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>W6QSF8</accession>
    <name>W6QSF8_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 13">Histone H2B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">htb1</name>
        <name evidence="16" type="ORF">PROQFM164_S02g002568</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the histone H2B family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QSF8"/>
    <dbReference type="STRING" id="1365484.W6QSF8"/>
    <dbReference type="OMA" id="FCPFAIR"/>
    <dbReference type="OrthoDB" id="10254238at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22910">
        <property type="entry name" value="HFD_H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000014">
        <property type="entry name" value="Histone H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000558">
        <property type="entry name" value="Histone_H2B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055333">
        <property type="entry name" value="HISTONE_H2B_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23428">
        <property type="entry name" value="HISTONE H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00621">
        <property type="entry name" value="HISTONEH2B"/>
    </dbReference>
    <dbReference type="SMART" id="SM00427">
        <property type="entry name" value="H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00357">
        <property type="entry name" value="HISTONE_H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="6 13" id="KW-0158">Chromosome</keyword>
    <keyword evidence="10 13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="12 13" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="11 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="15">
        <location>
            <begin position="36"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CDM32417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="141" mass="15114" checksum="21F0278AED2B8616" modified="2014-04-16" version="1">MPPKAAEKKPSTGGKAPVGGKAPAEKKEAGKKTATTATGEKKKRGKTRKETYSSYIYKVLKQVHPDTGISTRAMSILNSFVNDIFERVATEASKLAAYNKKSTISSREIQTSVRLILPGELAKHAVSEGTKAVTKYSSSAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W6QWD4</accession>
    <name>W6QWD4_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Delta(14)-sterol reductase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">C-14 sterol reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Sterol C14-reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">erg-3</name>
        <name evidence="16" type="ORF">PROQFM164_S03g000541</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">FM164</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="14">Steroid metabolism; ergosterol biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the ERG4/ERG24 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QWD4"/>
    <dbReference type="STRING" id="1365484.W6QWD4"/>
    <dbReference type="OMA" id="EWCELRP"/>
    <dbReference type="OrthoDB" id="10262235at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050613">
        <property type="term" value="F:Delta14-sterol reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1630:FF:000008">
        <property type="entry name" value="C-14 sterol reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001171">
        <property type="entry name" value="ERG24_DHCR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018083">
        <property type="entry name" value="Sterol_reductase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21257">
        <property type="entry name" value="DELTA(14)-STEROL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21257:SF52">
        <property type="entry name" value="DELTA(14)-STEROL REDUCTASE TM7SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01222">
        <property type="entry name" value="ERG4_ERG24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01017">
        <property type="entry name" value="STEROL_REDUCT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01018">
        <property type="entry name" value="STEROL_REDUCT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 15" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="10 15" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="8 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 15" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="13 15" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="9 15" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="12 15" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="4 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="265"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="334"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="442"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU369120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CDM33817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="496" mass="55856" checksum="73F59C47348EA5AC" modified="2014-04-16" version="1">MPTKKDSKKTPVQPVPEKRGYEFGGPLGAFGIIFGLPILIYLFTFVCNDVSGCPAPSLLNPSTLSLEQLKREVGWPEEGITALYDTNVTLWTLSYYVFSLFLQVFLPGQEADGVVLACRGQLKYKFNAFSSAIIILSGLTGGTYLYGADFVVWTFLWDNYVQVITANLLISSFAALFVYVRSFTVPAPGQANPNLRELAPGGHTGNMLYDFFIGRELNPRVRLPIPFVSEASRTVDIKVFMEMRPGLLGWTILNLSNVAHQYRTYGYITDSIVLVTLFQGFYILDALYMEPAIMTTMDVIMDGFGFMLSFGDVVWVPHLYSIQSRYLSVFPYELGLTGMTVVLGVTAVGYSIFRGANNQKNRFRTNPNDPRVKNIKYIETAAGSKLMISGWWGLARHINYLGDWTMSWAYCLPTGVAGYVLIESINPASGAAQKQAMQTPEIRGWGMIFTYFYMLYFGILLIHREMRDEEKCEKKYGADWKRYTSIVRSRIIPGIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>W6QWJ4</accession>
    <name>W6QWJ4_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 15">Signal peptidase complex catalytic subunit SEC11</fullName>
            <ecNumber evidence="4 15">3.4.21.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">sec11</name>
        <name evidence="16" type="ORF">PROQFM164_S03g000616</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalytic component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Specifically cleaves N-terminal signal peptides that contain a hydrophobic alpha-helix (h-region) shorter than 18-20 amino acids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins.</text>
            <dbReference type="EC" id="3.4.21.89"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="14">Component of the signal peptidase complex (SPC) composed of a catalytic subunit SEC11 and three accessory subunits SPC1, SPC2 and SPC3. The complex induces a local thinning of the ER membrane which is used to measure the length of the signal peptide (SP) h-region of protein substrates. This ensures the selectivity of the complex towards h-regions shorter than 18-20 amino acids. SPC associates with the translocon complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the peptidase S26B family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.89" evidence="4 15"/>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QWJ4"/>
    <dbReference type="STRING" id="1365484.W6QWJ4"/>
    <dbReference type="MEROPS" id="S26.010"/>
    <dbReference type="OMA" id="ILMNEYP"/>
    <dbReference type="OrthoDB" id="10257561at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005787">
        <property type="term" value="C:signal peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009003">
        <property type="term" value="F:signal peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019756">
        <property type="entry name" value="Pept_S26A_signal_pept_1_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001733">
        <property type="entry name" value="Peptidase_S26B"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02228">
        <property type="entry name" value="sigpep_I_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10806">
        <property type="entry name" value="SIGNAL PEPTIDASE COMPLEX CATALYTIC SUBUNIT SEC11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10806:SF6">
        <property type="entry name" value="SIGNAL PEPTIDASE COMPLEX CATALYTIC SUBUNIT SEC11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00728">
        <property type="entry name" value="SIGNALPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="LexA/Signal peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00501">
        <property type="entry name" value="SPASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 15" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 15" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU362047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CDM33892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="193" mass="21355" checksum="E760C85E9C35CFE5" modified="2014-04-16" version="1">MLSSLSSSITNARQSIAQVLNFALVLSTAFMLWKGLSVVSASSSPIVVVLSGSMEPAFQRGDLLFLWNRNTRAEIGEVLVYNVRGKSIPIVHRVVRTFPEVEGRASAKKVKEITVDTKPNSHMLLTKGDNNLADDTELYADGQDYLHRTDDIVGSVRGYVPMVGYVTIMLSEHPWLKTVMLGLMGLMVMIQRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W6QWU3</accession>
    <name>W6QWU3_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD-superfamily hydrolase, subfamily IIA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S03g000721</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QWU3"/>
    <dbReference type="STRING" id="1365484.W6QWU3"/>
    <dbReference type="OMA" id="HDKRMLV"/>
    <dbReference type="OrthoDB" id="10251048at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046474">
        <property type="term" value="P:glycerophospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000069">
        <property type="entry name" value="HAD-superfamily subfamily IIA hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050324">
        <property type="entry name" value="CDP-alcohol_PTase-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006357">
        <property type="entry name" value="HAD-SF_hydro_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006353">
        <property type="entry name" value="HAD-SF_hydro_IIA_CECR5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01456">
        <property type="entry name" value="CECR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01460">
        <property type="entry name" value="HAD-SF-IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269:SF57">
        <property type="entry name" value="SUPERFAMILY HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G02580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13344">
        <property type="entry name" value="Hydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13242">
        <property type="entry name" value="Hydrolase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM33997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="404" mass="44564" checksum="B2E0FD8198509B7C" modified="2014-04-16" version="1">MRSQTLWRSFGLLQRQSLSTHKTVTRRAIQTASSRPIPNFAFAFDIDGVLLRASKPLPGAADSLALLKKQGIPFLLLTNGGGKHETERVAEISEKLGIPLDATDIVQSHSPFAELVKGPDESSALEHKCVLVAGGDGDNCRRVAERYGFKNVVTPADILMANPAVCPFSMNFSEYYKTFARPLPHPVDFNDASKTLKIDAVFVFNDPRDWALDTQVIMDLLLSSQGRLGTLSEKNGRIDLPNHGYQQDGQPHLYFSNPDLWWAAAYPLPRLGQGGFREALEGVWAAATGGPSKGIELKKTVIGKPYQPTYQFAERQLLRNRLRTFGSSAESTPLERVYMVGDNPESDIRGANSYRSEIGSSWHSILVRTGVYRGGEPAWIPETIADNVQKGVQWALKNSNWPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W6QZT2</accession>
    <name>W6QZT2_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S03</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S03g001804</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM35077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QZT2"/>
    <dbReference type="OrthoDB" id="4329373at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="87"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM35077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="116" mass="13211" checksum="09BD8CE3C85BAAE0" modified="2014-04-16" version="1">MIDTSFWHLWKLILQQDSLAVGPFEVVLKAPLHTPAGEDSVHPWNMSLSNDHPGVVSRDDVSYLRWNRARNDPAPLDCRCLSKAQRDSIPSPSRSRSRSTSASKDLPQRMRDDQFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W6QZW6</accession>
    <name>W6QZW6_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Probable transposable element</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S03g001839</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM35112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QZW6"/>
    <dbReference type="STRING" id="1365484.W6QZW6"/>
    <dbReference type="OMA" id="QKQVPRM"/>
    <dbReference type="OrthoDB" id="4159828at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM35112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="271" mass="30460" checksum="0D2F310655B1D4E5" modified="2014-04-16" version="1">MQYYICTTLSQKQNPFSAELAAVAHTLKTLVGLKDFRITLITSNKAAALTLKNPRQQSGQEFVCQSYKLMSRLQRHGNQISVRWVPTSEDNKLLGMAKEHARAATQENAISQVQVPKMKSTTLKIARAQAIPSRKLPEDIGRHSSRVDTALPGKHTRQLYDRLSWKEASVLAQLRTGMARLNGYLFRINAAETDQCACGQARETVDHFLFRCRKWTAHRTEMLQCTHTRRSNMSFFLGGKSPSDGQKWTPNLEAVRASIRFAIATGRLGAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2024-10-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>W6R1T4</accession>
    <name>W6R1T4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S04</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S04g000648</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6R1T4"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM35767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="57" mass="6210" checksum="0AA6EA43C083D02D" modified="2014-04-16" version="1">MPNAKTLVSRQEWSPIIYSVLRNSFAAADADSRVPDMDSVIASFSSLRVIVVLNASI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W6R4A9</accession>
    <name>W6R4A9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Amino acid transporter, transmembrane</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PROQFM164_S05g000480</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6R4A9"/>
    <dbReference type="STRING" id="1365484.W6R4A9"/>
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    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF668">
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    </dbReference>
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        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="127"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="184"/>
            <end position="208"/>
        </location>
    </feature>
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        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
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        <location>
            <begin position="260"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="302"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="344"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="377"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="410"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="7">
        <location>
            <begin position="53"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM36647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="454" mass="49432" checksum="304ACB75D3E53AB2" modified="2014-04-16" version="1">MSVPEAPHPIQDYEVYNDSTDMEKKAYPVDPPDDPFGNEESGEVKYRIMPWCVHVVMVAENISLGILSLPSAVATLGIIPAFVIIMFLSAISWYTGYTMGQFKQRYPQVHSMGDAGELLLGPIGREIFFVGQLLFIIFLMASHILTFSVLFNTITNHGTCTIVFGVVGLVVSCVAALPRTAEKVFWMSIISAISILVATIVTMISIGVQAPSDVQNDIVATPTFQEGFLAVTNIVFAFIAHVSFFGIMSEMQDPRDFPKALAMLQVIDTTMYVVTAMVIYCYAGPTVESPALSSAGPIMKKVAYGLAIPTVIVAGVVFGHVACKYIYVRIFRGDRSHHMHQKTFLATGTWVAIGLTTWTVAWVIAESIPVFNELLSLISALFGSWFSYGLPAIFWFMMNKGKLFSSTRKIALTIINLAILGIACTICGLGLYVSGVAINESSSNASWTCANNAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W6R6X4</accession>
    <name>W6R6X4_PENRF</name>
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        <recommendedName>
            <fullName evidence="5">Serine-rich protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S06g000554</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792020">
        <property type="protein sequence ID" value="CDM37592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6R6X4"/>
    <dbReference type="STRING" id="1365484.W6R6X4"/>
    <dbReference type="OMA" id="HSWSPHL"/>
    <dbReference type="OrthoDB" id="4153178at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="636"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="699"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="382"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="495"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="75"/>
        </location>
    </feature>
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        <location>
            <begin position="83"/>
            <end position="97"/>
        </location>
    </feature>
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        <location>
            <begin position="110"/>
            <end position="122"/>
        </location>
    </feature>
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        <location>
            <begin position="131"/>
            <end position="141"/>
        </location>
    </feature>
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        <location>
            <begin position="150"/>
            <end position="159"/>
        </location>
    </feature>
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        </location>
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        </location>
    </feature>
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            <end position="269"/>
        </location>
    </feature>
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            <end position="282"/>
        </location>
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            <begin position="284"/>
            <end position="314"/>
        </location>
    </feature>
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        <location>
            <begin position="444"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="505"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="560"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM37592.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="726" mass="79030" checksum="B90999A9DE979E9F" modified="2014-04-16" version="1">MSFPARSTSPRARRPLHERTPSHSNERSPTRSLRIVPDEELDMYTATPFPTKPEQILLPLPGKGQQQYISDTGFSYSDHHLGSSTSTYSSPAFSHPAPHSPRDHSIGSWDVSSTVDTGNSPPQLWDDDPSSSKSSLPGSGKAPDYGSESSEADFSDDDMGLPTTTPTIKAVRSESTMSPKSSAESVTGYSSPIVEQIGAPSSPNFVMLDNSSMNFHSESDPRTNSLSSYNSGGTVVRHVGSAPWFQNAFQPASSEQSSYGSPSFHSSPPAQSIASFHSSPIAQSIASFRSSSRAPSGSRSQSATSSSRSLRSASDLQAAIDNGVPIQYPRIRAPSSSSRTGASSERDFTPGPPSGRCNPHLASGRWNPHLSTVSSIWSADESTKLAGEADTDSDRDMAAPTPPPPAALATETTRSSVWLVDPSNDSEDERLDSLTKLPNRPVFSQSQSLSSGSKRSDSTRSLQRPGTGSSTILNILPTWAKVYYLREPMGLNSTLSMMDASRPPSIRPPSTRPPSTRPPSSRPGTSNSSIFNLVPGPLNVPRPRSPDRPLPDAPRSQEITQRRVDSDPRDPRAHWVPSPQPEDGEFTSSHLYRLRHSWSPHLVPDRRVVQHSTSRWRPPSLDSRYEPVLGRRNIQVYSFCLGFIFPPAWCVAAFLPLPPKPKAAQMVEFHSPDVGMALEAQNVNLQQRRRDNARWWRNLNRWMISLGVAILVIIIVLAVIGTTTGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W6PQB5</accession>
    <name>W6PQB5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Selenoprotein, Rdx type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S01g000177</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PQB5"/>
    <dbReference type="OMA" id="EYCTQCR"/>
    <dbReference type="OrthoDB" id="60822at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011893">
        <property type="entry name" value="Selenoprotein_Rdx-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02174">
        <property type="entry name" value="CXXU_selWTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36417">
        <property type="entry name" value="SELENOPROTEIN DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G05220)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36417:SF2">
        <property type="entry name" value="SELENOPROTEIN DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G05220)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10262">
        <property type="entry name" value="Rdx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="122"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM26368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="154" mass="17134" checksum="B0D3B6B6F90FA5C4" modified="2014-04-16" version="1">MAESALTPLDSTPNKSDTIAPANVHLPRISIQFCTQCRWMLRAAYFAQELLSTFSTDLGEVALVPKTGGVFTVTIWHGTMNDGEITTQESILWDRKRDGGFPEVKALKSLVRNVIAPDRDLGHTDRALKKQQGEQKEVKEEEKSKGKADCEDCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W6PQY0</accession>
    <name>W6PQY0_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type DNA-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PROQFM164_S01g000074</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PQY0"/>
    <dbReference type="STRING" id="1365484.W6PQY0"/>
    <dbReference type="OMA" id="CSLVRIY"/>
    <dbReference type="OrthoDB" id="4222821at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="14"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="83"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM26265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="538" mass="60851" checksum="9BD5267702EB168C" modified="2014-04-16" version="1">MHSIHNYRHSRRSACDRCRGQKLRCERDHMNGMSCERCLKAQEICITSMNQPAPVILPSNYGHNIVAREDRESQRFNQRHQSMSVLHKSSGPRVKKLLHSPSPIPGRYNTKEHQNWGGVASMPGFPGGSFHSPSVEVGFNMPLDFGNIMAPVEHWGDPHSNSSTDGYNLSSDWIPSDEMYAYEGNSWLPSVFTSDAPLGARQATEMAIYEPFQTKRLNHGENESPFAMKEFPDPAWVNHQTIRKPPANTTSQGALLSIQDIRKSLLRLKVELLEDLEIFETGSMLLESSSLFYENSNLPIETLDLPIYRLLDHSSWLLAIVRSSCGMTEETLDVAFATQRFETESSGYEDSLFIFSENGGNGLDEDVTTVSPHDSGYHTTTTSPDQATTRAIPKFDIALWLGILEAHCSLVHIYRAVFMRLYQLFLIIPPTDATTILLLPKVHFGQFHLDGNLIAQVQVLVEFSSTMLGKLDRALKFRSGPSQSQEDREFDRSETIRQKDWSNSIRDIVIAQEQDPCEMSLMEIMECLRQLVKEPVII</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W6PRI3</accession>
    <name>W6PRI3_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g000597</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PRI3"/>
    <dbReference type="STRING" id="1365484.W6PRI3"/>
    <dbReference type="OMA" id="EPLAHIC"/>
    <dbReference type="OrthoDB" id="5317787at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM26788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="444" mass="50092" checksum="D400F557DD0F7271" modified="2014-04-16" version="1">MGSYKSSQPGSYSSTDSTSSKSTTATIHSDRLTPKPHKTDEATNPAPPKHTYKYETKGEVVYECREPHPRASTSTYASTTYSTAELDLEPQPAESASPHEGRYCVNERLEFYPLEAIPSTPSSFAPLFPSSRRLLIRHDDATVDGNMNLRVGTPVHLRDGSQRDVILFHLRMYDLLARKFSFRRYCRDSGREVCNSARREVVPAHGRRPALRTSWSSVFAGLRPGSAGGHCPTDELKRQHSRLGGGYGHGHPAGDEVDKGMTEENEWEKEGKSALPILGETILIEFSNYAHVELRRKGPGSTKKYEFEYWSTKYQWRREVRKEGDLHEVSYFLVDTRNSKTIAHLVPDTLAPLEVVEEESKGGWVPPSSLWISDPEVYKTMPDVADVIVATGIVALVDDCIRRRWHHERRPSWILPAQHSLVKSLERMGPRRLIGQVLQRRGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W6PRU3</accession>
    <name>W6PRU3_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Amino acid transporter, transmembrane</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PROQFM164_S01g000399</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PRU3"/>
    <dbReference type="STRING" id="1365484.W6PRU3"/>
    <dbReference type="OMA" id="FWIPPIM"/>
    <dbReference type="OrthoDB" id="655540at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF8">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="91"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="135"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="196"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="247"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="280"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="322"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="364"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="395"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="428"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="8">
        <location>
            <begin position="59"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM26590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="473" mass="50699" checksum="0F9D357F2CF72C5A" modified="2014-04-16" version="1">MADERGYGSFHPGDNGPSPVMGCASPQPQADENTKLLSNDGDAGFEDQRVIEGHANFHRLGWKRLTVVSIVEAIALGALSLPQAFAVLGMIPGIVICVGMGIVAIYTSYIIGAVKIKFPSVAHYGDIGQLMMGSFGYWLFSVIFVFQLTLSVGSHCLTGMIAFANITESTICALVFGGISAVILLLLAIPPTFADVAILGYVDFVSIILAIGVTMVGTGIQQAQMPGGLASSDWSYWPAEDVTFPKAAVAISNIVFAYAFAGALPSFMNEMHTPKDYVKSITALGVIEISIYVLTGSIIYAFVGQDVQSPALLSAGPVMSKIAFGIALPVIFISGSINTTVVCRFIHTRIYRDSVVQYVNTVKGWVTWLALVVAVTLIAWIVAESIPFFSELMAISAALLVSGMSFYFPPVMWLLLLKDGNWHDRKNVWHAVCNLVCFLIGIAVLGGGVYASIFELIRKFQDGNMGKPFSCSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W6PRV9</accession>
    <name>W6PRV9_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S01g000419</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PRV9"/>
    <dbReference type="STRING" id="1365484.W6PRV9"/>
    <dbReference type="OMA" id="FVTHIAD"/>
    <dbReference type="OrthoDB" id="4540793at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM26610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="418" mass="48709" checksum="94D2FAA75415E58F" modified="2014-04-16" version="1">MHGSFEFALRFAQDNQDVSSDEDDRKEPIIDDRFARLVSHGRSFIEESAAFQKLRVELKNFLMPTFKPIFLDFRFDSDEWMIRCFWCMEKLLSSIGPLEESDSSHLFSTRPSVLTPSREIVLFSEPIALDTNVHSTELPTPWSSIQVIGNLGLSFKLNRLQWARSTRFTWEYVGVESNVDMKDFKGTISWDPAKLLRKLYLREKKVPKYHKRFRWKNRHGKRLYDDYIEHEHGALQALHNYLDATTVPNKGMTPSESVQSSSYAARLYTPNAPSTQTTYPLTTIDIADQPATNPYNFETSNVFHDVEQPTKSTRSLLLLTCIKRHGRPVKLHQEFVTHIADDRQLFHALRKIYFNHRQKFEFFWSLRTLHSIHFMRFIYAGNSYIDVRCHAEICTPSNPCACVPPPGLVPPQVTYNYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W6PS55</accession>
    <name>W6PS55_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Methylsterol monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ERG25</name>
        <name evidence="6" type="ORF">PROQFM164_S01g000509</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PS55"/>
    <dbReference type="STRING" id="1365484.W6PS55"/>
    <dbReference type="OMA" id="IVHEFIY"/>
    <dbReference type="OrthoDB" id="1658724at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050307">
        <property type="entry name" value="Sterol_Desaturase_Related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11863">
        <property type="entry name" value="STEROL DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Fatty acid hydroxylase" evidence="5">
        <location>
            <begin position="100"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDM26700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="257" mass="30195" checksum="57D11569C90EAD87" modified="2014-04-16" version="1">MQNDVLATGIMSFVMHELVYFGRSLPWIFIDTFAMFNRYKIQGNKIPSLREQWDCAKFVLLSHFTVELPQIWLFHPLAQFCGLSTSIPFPTLWTMAYQIAIFFVMEDTWHYFSHRALHWGPLYKAIHKIHHQYSAPFGLAAEYASPIEVMILGFGTIGCPIVWCAMTGELHILTMYIWIVLRLFQAIDAHSGYEFPWSLHHFLPFWAGADHHDLHHEKFIGNYSSSFRWWDYVLDTEYTPDALKRRRENKAKASKAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W6PUM8</accession>
    <name>W6PUM8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S01g001282</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PUM8"/>
    <dbReference type="OMA" id="QIHQIAR"/>
    <dbReference type="OrthoDB" id="2772415at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM27471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="118" mass="13199" checksum="65EE3AB61CE374F0" modified="2014-04-16" version="1">MSAPKGPFHLVSVNTAPERARRLIGRVAEALSDRYTIIHVDNCERIDEVEAKVKQHNPEVLFSASMWTAEEAAQIHQIARSVRPDIKLHAIPEGLQVERGPDAIVEYLLEKVPVLLDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W6PWA1</accession>
    <name>W6PWA1_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g001877</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PWA1"/>
    <dbReference type="OMA" id="GRIYWFK"/>
    <dbReference type="OrthoDB" id="14339at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37332:SF1">
        <property type="entry name" value="ELMO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37332">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM28066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="318" mass="34376" checksum="74C9BA146A2110D1" modified="2014-04-16" version="1">MIPSTFAPSITRRDTTKSGVGLETAYGIPPPVMSGGGSLGPQSAGAIYQHIHEMASKRIATLDYLRKAHEGRVYWFNTVHFSRADIARLPYFEARKLSRRAINYLLLGLSLPTILDVNTTPFEYVRALNALLLEFEAFQQVHPPEGSSSSSLARARIPQMFKRAAHGGTKTRRASSANEIGLPMQSSDPSDLKNTAGNLGSAASASVTSFPLTESSDLHPGEEYTYLLTPSLPFEPDFFETFATLCDVLIDTYSRLCALVASPSVCTVALGEIFSKADARLRKIMVAGAVREFEDASRNSVKSEIAGVSRVVLGGLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W6PWR2</accession>
    <name>W6PWR2_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g002181</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PWR2"/>
    <dbReference type="STRING" id="1365484.W6PWR2"/>
    <dbReference type="OMA" id="FGEAMHW"/>
    <dbReference type="OrthoDB" id="5413829at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2790">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="296"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="300"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM28370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="344" mass="37699" checksum="B1590FBE96432230" modified="2014-04-16" version="1">MASQTYSSSVRAGLKPSNPAPPNFADPNFDPAEFLNDSLSPLTVASAQPSASRSPGSVPLTELSTQVQSLLSQISAQNIRLSSTLSQLTDEILRSGGRLAYEVEVLRGETIGLSETLTEVLRDDITKFVPGPSPEDGRKAEQEEDAPTNEDESAETEDKNKPAAPTDPEYITNLRTLNQVRSRLEDVVQTFGDAMSWPLPPSEISFSSSFISVSGPDLGPEGQDREEKGQEMMKKLRAEVTELLDSEGGGYAGLDAANRRVEALRTLAIVWNASAEEKARNRFVDSLANIVEDRRRTLDQQQADQNQRGQSKSRFEARRDSDSGAPAGGLFRNLQRLREEIYLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2024-10-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>W6PWT0</accession>
    <name>W6PWT0_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S01g000223</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PWT0"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM26414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="73" mass="8178" checksum="A149E6A5B9D4FCF1" modified="2014-04-16" version="1">MIDTPLTGHAGYPGTWLRLLSPASLSGVSGFLQAGRYSLERRHRPSDLRSFFRGYCPLRHSSRYEGIGVKIDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W6PX59</accession>
    <name>W6PX59_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">General negative regulator of transcription subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PROQFM164_S01g002609</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Acts as a component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover. The NOT protein subcomplex negatively regulates the basal and activated transcription of many genes. Preferentially affects TC-type TATA element-dependent transcription. Could directly or indirectly inhibit component(s) of the general transcription machinery.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1365484.W6PX59"/>
    <dbReference type="OMA" id="IDEYHCY"/>
    <dbReference type="OrthoDB" id="1933107at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030015">
        <property type="term" value="C:CCR4-NOT core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd20710">
        <property type="entry name" value="NOT1_connector"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000012">
        <property type="entry name" value="Ccr4-Not transcription complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.840:FF:000002">
        <property type="entry name" value="Ccr4-Not transcription complex subunit (NOT1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.790:FF:000003">
        <property type="entry name" value="CCR4-NOT transcription complex subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.800:FF:000003">
        <property type="entry name" value="CCR4-NOT transcription complex subunit 1,putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.840">
        <property type="entry name" value="CCR4-NOT transcription complex subunit 1 TTP binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007196">
        <property type="entry name" value="CCR4-Not_Not1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055454">
        <property type="entry name" value="CNOT1-like_NOT1_connector"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032191">
        <property type="entry name" value="CNOT1_CAF1_bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024557">
        <property type="entry name" value="CNOT1_dom_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032194">
        <property type="entry name" value="CNOT1_HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032193">
        <property type="entry name" value="CNOT1_TTP_bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038535">
        <property type="entry name" value="CNOT1_TTP_bind_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040398">
        <property type="entry name" value="Not1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13162">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13162:SF8">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25097">
        <property type="entry name" value="ARM_Cnot1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16415">
        <property type="entry name" value="CNOT1_CAF1_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16418">
        <property type="entry name" value="CNOT1_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16417">
        <property type="entry name" value="CNOT1_TTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12842">
        <property type="entry name" value="DUF3819"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04054">
        <property type="entry name" value="Not1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="CCR4-NOT transcription complex subunit 1 HEAT repeat" evidence="13">
        <location>
            <begin position="640"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="domain" description="CCR4-NOT transcription complex subunit 1 TTP binding" evidence="12">
        <location>
            <begin position="819"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="domain" description="CCR4-NOT transcription complex subunit 1 CAF1-binding" evidence="11">
        <location>
            <begin position="1034"/>
            <end position="1255"/>
        </location>
    </feature>
    <feature type="domain" description="CCR4-NOT transcription complex subunit 1" evidence="10">
        <location>
            <begin position="1318"/>
            <end position="1456"/>
        </location>
    </feature>
    <feature type="domain" description="CCR4-NOT transcription complex subunit 1-like NOT1 connector" evidence="14">
        <location>
            <begin position="1640"/>
            <end position="1748"/>
        </location>
    </feature>
    <feature type="domain" description="CCR4-Not complex component Not1 C-terminal" evidence="9">
        <location>
            <begin position="1925"/>
            <end position="2293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="80"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1533"/>
            <end position="1554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="9"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="134"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="156"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1545"/>
            <end position="1554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00059181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00074459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF16417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF16418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF25097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CDM28798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="2306" mass="257313" checksum="3EF16067F2E614C7" modified="2014-04-16" version="1">MTFPPPHPSAQSSIASGTDKSSSTRTDIGAWGRSVSQSGARRGLTPLATNISSAAPPTASRGLDAGLGVSTPSSFSAVLSSARGLSGGSPKHTSSPFTSLQSGSQQHATTLSSPKFRAHTPSIGSHLASATGSAPGGGGTGGGGGGPGSSRGVFSPLSSGTTVNSPTGFASDKPGSTNAHSSQSSLTKISIAQVFLLLDSITEKEGKEKWETKAAQIHKLVTSNGMEVFSKYFRRLLTGNAPQIFPGVNKSVENAGNYPLLVQEMQKVSSDMEQSQKIAETVDTSEGDIFRDFDLSTFLDHFRLDPVVKVSLALAFKLTSKSDLRAKADAILSNSIAPFLQSLASPTEVTKDYSNSFLGMTIERFILYPPRNFTDDVKAKLVYAANLRFQKLGLDMPFEVSSALQMFNFVNPQYVLVRQLHAKGARATAHTETISELLNSDQRNWSEEHLASALLFMILSQYWEQFSLETFLSAYNDKPINWPLVFRHFDREGLRVDPKQFTKLYNVLSAMSVDDSSLDVQKLWGGDWEHRDTQMSFLTAFVASRIDPSHIPNLRATFPTDFFEDAPEIVKLQGERAAKSPLRSMDAMKAIFDLALFSQASWAATESQLLIKAVVQFDLPVFLVSALAIPQPWTSVQQSFVLRTFIVFISKQEDGYQLALQGAWRQERQWVSEQLFTTFTQDPTSTAVIYEHAAAYGWLDYLLGFTNGLALDLACYSHRKSPFDLEQWVRNAAQKGAIDMGGLLSKFLRIKAEDELHVQRKEQSAHQMVSLAVKTVYTLLSVLEEYVGDRENLTPVQRICIQTYPRLINYGEGFDDIIDANGENGNTLPESIDKQMQELFGKMYHEELSLREMLELMRKYKSSRDPTEQDLFACMVHGLVDEYHCYHEYPLEALTKTAVMFGGIINFRLVDGITLKVGLGMILEAVREHEPHDPMYKFGVEAIEQLINRLPEWAGFCHLLFQIPSLQGTPIYQKAEEVLREQGNQIGEAEAGPFDGLASVPLTNGNSVDSPIADGSVRKFRAVQLDPPLRSELYEEPDEDIQDKILFVLNNVSEQNIDEKLEDLREVLRDQHHQWFAAYLVEERAKLQPNFQQLYLDLLGRIGDKILWAEVLRETYVSVAKLINSEGTLTSSTDRGHLKNLGAWLGSLTIAKDKPIKHKNIYFKGLLLEGYDTQRLMVTIPFTCKVLVQATKSTVFKPPNPWLMDILGLLLELYHFAELKLNLKFEIEVLCKDLDLDHKTIEPAIVIRDRAAHAEEQLSTVNAPEGLEPFEDLSLSAINPAIRNERLSPAAIMSTLPSLDKILVLPSSASSMVDPTILKQIVHTAVERAIAEIITPVVERSVTIASISTVQLVSKDFAMEPDEERVRHAAGIMVRQLAGSLALVTCKEPLKVSMTNYIRMIQQEYSEQPMPEGLILMCVNDNLDAACGIVEKAAEEKSLPEIEKVIEPQLEARRRHLASRSNDPFIDPSMNRWGLFIPEPYRQTPGGLNKEQLAIYEEFARQSRGPAPSTDASAGRQLPDVLGESYPAIPNLSTPAEQPAIPHRTPQTQPAVSQMPPVQTNGFLDAQSPRERVESLVSDLQQSARSAPEEHVKDLGRDSAVLQEYNQALRSILASTNGEELARLTSLKVCTLLYSQPHGSLEIEVLVHLLAKLCDMSSLIARYTWALLSEVDDEHMFNVPVTVALIDAGLLDIRRVDTNLTRLILSRNVPALELLGNLMDRVLFNEEPSALRSDFSGSLDAMSQWLAEDGSVAPGLEIVRKLRESGIPEVINSLLTDQARSKRDQMEYIFSEWIGIYKAPGATDRTFHSFLQDLHNRQVMNSQEDSALFFRLSIDISVAMFEHESQNPNGGSLDEAFLYIDALAKLVILLVRFQGETAGAVKASKATYFNSILSLLVLVLNHHQVMRGEAFNQRVFFRLFSSILCEYSMNGLQHTEQHQGMIFALANKFLSFQPRYVPGFVYGWLCLVSHRVFMSDMLNMPDRAGWAPYCEIIQALLSYMGEQLKAANITYVAKDLYKGVLRILLILHHDFPEFVAENHFQFCNVIPAHCAQLRNLVLSAYPSSFQKLPDPFREGLKVERIEEMREIPKIAGDIVAPLQLANIKDVVDDVLQNDNISDSAVQQLCDAILNPEFKETGLLFVPVDVDVVLVNALVLYIGQQAAVEHASKGNTRSAFENSTHAALLEKIAQVLRPESRYYLLSAMANQLRYPNSHTYFFSFTILRLFGVDYSEQDDSDIRQQIIRVLLERLIVHRPHPWGLIITLQELLQNRSYSFFRLPFIQAAPEIGRLFDALLQHIQQQSPRPIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W6PX73</accession>
    <name>W6PX73_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g002366</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PX73"/>
    <dbReference type="OMA" id="YFYRCFS"/>
    <dbReference type="OrthoDB" id="3783227at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056009">
        <property type="entry name" value="DUF7587"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24494">
        <property type="entry name" value="DUF7587"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7587" evidence="1">
        <location>
            <begin position="5"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM28555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="249" mass="28968" checksum="B63CCB84183D4D0C" modified="2014-04-16" version="1">MKYQYFYRCFSLTSAGGPRSGAYDNYFDRPKLSEHALLSEFDSHRNRWNGHPTALVSVTDRPLEALNRALGKYNSRNEDKIWIICIKVPKADVENGPHHAQRLAEELGLDSNVFRHEYLFEWEIPEDYILRIVSLRAILAWRIEDMRPLEHGVEEVSFSTLRDAFRREILTPDPYATGRWLYRLTKAFRTCGPRIAFQIYLDSLGGGFFDSNNQTVRYDGFGCIEFSDISYIEQQIGNGIDDEFENDCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W6PY73</accession>
    <name>W6PY73_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ornithine decarboxylase antizyme</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PROQFM164_S01g003025</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis in response to increased intracellular polyamine levels. Binds to ODC monomers, inhibiting the assembly of the functional ODC homodimer, and targets the monomers for ubiquitin-independent proteolytic destruction by the 26S proteasome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Interacts with ODC and thereby sterically blocks ODC homodimerization.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ODC antizyme family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PY73"/>
    <dbReference type="STRING" id="1365484.W6PY73"/>
    <dbReference type="OMA" id="RLFCETM"/>
    <dbReference type="OrthoDB" id="6407410at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008073">
        <property type="term" value="F:ornithine decarboxylase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045732">
        <property type="term" value="P:positive regulation of protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0075523">
        <property type="term" value="P:viral translational frameshifting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002993">
        <property type="entry name" value="ODC_AZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038581">
        <property type="entry name" value="ODC_AZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10279">
        <property type="entry name" value="ORNITHINE DECARBOXYLASE ANTIZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10279:SF10">
        <property type="entry name" value="ORNITHINE DECARBOXYLASE ANTIZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02100">
        <property type="entry name" value="ODC_AZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0688">Ribosomal frameshifting</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDM29213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="248" mass="28039" checksum="DFFE60637853CB7B" modified="2014-04-16" version="1">MAKYMNNHSSNCNQMQRFLDQDSQSTVLATCYSVEPSTSKVHGFHYCTTLGAGKSPPHDILDSRADRTWPGNSWPEYKGEATHNIPEECERLFCDRLSATFLGERKIVGQESLGMDAFRNVQSNQIGLQHARIQQWIEVWDYTSDAIYRGFVAEHNKERTLFVFFEDRALEHGLKSGLIALFELADIATFGCSQIVACVSRSQRTDEMELVRSLGWCGFSLTTLAPWVSHSDQGPCLSNKWLFLAAEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2024-10-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>W6PY94</accession>
    <name>W6PY94_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S01g002791</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PY94"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM28980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="42" mass="4675" checksum="53CCE1F9C60302D9" modified="2014-04-16" version="1">MEREGCGLGVMDYFGWCHSVGDSATVHTSLYQNYINGMTKES</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W6PYU8</accession>
    <name>W6PYU8_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">pyridoxal kinase</fullName>
            <ecNumber evidence="2">2.7.1.35</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PROQFM164_S01g000943</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the pyridoxine kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.35" evidence="2"/>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PYU8"/>
    <dbReference type="STRING" id="1365484.W6PYU8"/>
    <dbReference type="OMA" id="WEGLKQS"/>
    <dbReference type="OrthoDB" id="2104723at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008478">
        <property type="term" value="F:pyridoxal kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009443">
        <property type="term" value="P:pyridoxal 5'-phosphate salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01173">
        <property type="entry name" value="pyridoxal_pyridoxamine_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1190.20:FF:000070">
        <property type="entry name" value="Putative pyridoxal kinase C6F6.11c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013749">
        <property type="entry name" value="PM/HMP-P_kinase-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004625">
        <property type="entry name" value="PyrdxlKinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00687">
        <property type="entry name" value="pyridox_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10534">
        <property type="entry name" value="PYRIDOXAL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10534:SF2">
        <property type="entry name" value="PYRIDOXAL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08543">
        <property type="entry name" value="Phos_pyr_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyridoxamine kinase/Phosphomethylpyrimidine kinase" evidence="7">
        <location>
            <begin position="114"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM27134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="368" mass="40034" checksum="A1CD5CF25D1EE778" modified="2014-04-16" version="1">MDSLVPETRVLAVASHVVYGHVGNTMATFVMQSLGCEVAAINTVHFSNHTGYRQFKGTRATAQEISDLYQGLCQSNLTDFDVMLSGYAPSAAAVETVGAIGIDLQKKAEKKPGSFFWVLDPVMGDQGRLYVNDDVVPAYKKIIPFADLILPNQFEAETLSGIKITSLATLASAVTAIHRIYSVPHVIVTSVQLFKLSQSGSTPSPPENFLTVIGSTTRSDGSPRLFRVDIPALNCFFSGTGDMFAALTVARLSEAVSAVDGLRTTKSWVSPDDVVATDLPLASATVKVLSSMHSVLERTLESRDAELAVPAPALEGEVSAEELEKRDYLRKTKAAEVRLVRNTRFLRDPKIIFKVQDWKKADLPEELR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W6PYW7</accession>
    <name>W6PYW7_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Deoxycytidylate deaminase</fullName>
            <ecNumber evidence="7">3.5.4.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">dCMP deaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PROQFM164_S01g003022</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM164</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytidine and deoxycytidylate deaminase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.12" evidence="7"/>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PYW7"/>
    <dbReference type="STRING" id="1365484.W6PYW7"/>
    <dbReference type="OMA" id="YFMRLAD"/>
    <dbReference type="OrthoDB" id="6710946at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004132">
        <property type="term" value="F:dCMP deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009165">
        <property type="term" value="P:nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01286">
        <property type="entry name" value="deoxycytidylate_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000035">
        <property type="entry name" value="dCMP deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002333">
        <property type="entry name" value="Deoxycytidylate deaminase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016192">
        <property type="entry name" value="APOBEC/CMP_deaminase_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015517">
        <property type="entry name" value="dCMP_deaminase-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035105">
        <property type="entry name" value="Deoxycytidylate_deaminase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11086:SF18">
        <property type="entry name" value="DEOXYCYTIDYLATE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11086">
        <property type="entry name" value="DEOXYCYTIDYLATE DEAMINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00903">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="10">
        <location>
            <begin position="189"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00071582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDM29210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="352" mass="39861" checksum="718C0B148F96951D" modified="2014-04-16" version="1">MLIGLCGGICAGKHAIADYLIQQGFQLLELADTPQYHTTDLEDDLRLQASEIRKKDPKSPKLIFQDADSLLDFATKRWQERWVTTDIADPTTLDRFLLRPFFLLVSVDAPIGLRWKRFADRCWRRQLDPPELEKFIMWNDHNLYDQDTGRVYLTDKAQLRLFNSSTGLKELHSALQTLDLENEQRLRPNWDQYFMQLASLAARRSNCMKRRVGCVLVRESRVISTGYNGTPRHLQNCNQGGCPRCNRGDGGGVGLSTCLCLHAEENALLEAGRERIREGTILYCDTCPCLTCTVKIAQVGISEVVYSQGYNMDSDSAAILQEAGVRLRQFHPPTNGLIVLQAPKIPVTTETQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>W6PZ79</accession>
    <name>W6PZ79_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="20 21">Cytochrome b-c1 complex subunit Rieske, mitochondrial</fullName>
            <ecNumber evidence="3 21">7.1.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">PROQFM164_S01g002847</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>a quinol + 2 Fe(III)-[cytochrome c](out) = a quinone + 2 Fe(II)-[cytochrome c](out) + 2 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:11484"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="7.1.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="21">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
        <text evidence="21">Binds 1 [2Fe-2S] cluster per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="21">The Rieske protein is a high potential 2Fe-2S protein.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Rieske iron-sulfur protein family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.8" evidence="3 21"/>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6PZ79"/>
    <dbReference type="STRING" id="1365484.W6PZ79"/>
    <dbReference type="OMA" id="KRTWLIA"/>
    <dbReference type="OrthoDB" id="1637982at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008121">
        <property type="term" value="F:quinol-cytochrome-c reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd03470">
        <property type="entry name" value="Rieske_cytochrome_bc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.270:FF:000002">
        <property type="entry name" value="Cytochrome b-c1 complex subunit Rieske, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.102.10.10:FF:000001">
        <property type="entry name" value="Cytochrome b-c1 complex subunit Rieske, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="entry name" value="Rieske [2Fe-2S] iron-sulphur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.270">
        <property type="entry name" value="Ubiquinol cytochrome reductase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037008">
        <property type="entry name" value="bc1_Rieske_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014349">
        <property type="entry name" value="Rieske_Fe-S_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005805">
        <property type="entry name" value="Rieske_Fe-S_prot_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004192">
        <property type="entry name" value="Rieske_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006317">
        <property type="entry name" value="Ubiquinol_cyt_c_Rdtase_Fe-S-su"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01416">
        <property type="entry name" value="Rieske_proteo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10134">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT RIESKE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02921">
        <property type="entry name" value="UCR_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00162">
        <property type="entry name" value="RIESKE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="ISP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81502">
        <property type="entry name" value="ISP transmembrane anchor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="18" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12 21" id="KW-0249">Electron transport</keyword>
    <keyword evidence="14" id="KW-0408">Iron</keyword>
    <keyword evidence="15" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="17" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16 22" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 22" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="11" id="KW-1278">Translocase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 21" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Rieske" evidence="23">
        <location>
            <begin position="167"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00029351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00072517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="RuleBase" id="RU004494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="RuleBase" id="RU004495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="CDM29036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="237" mass="25842" checksum="57B67C423CB54301" modified="2014-04-16" version="1">MSLSSASSTLLRTVARQQLPISRAAVTSCQQRRGVADSKSSFESPFASANEPGSTLKIPNFSKYKSNNSPRTNQVFSYFMAGTLGLATAVGAKATVQDFLVNMSASADVLAQAKVEISLGAIPEGKNVIIKWRGKPVFIRHRTQAEIDEARSTNWETLRDPQPDEDRVQRPEWLVMLGVCTHLGCVPIGEAGDYGGWFCPCHGSHYDISGRIRRGPAPLNLEVPTYSFPEDETLIIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q010</accession>
    <name>W6Q010_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S02g000002</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM29853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q010"/>
    <dbReference type="OrthoDB" id="10268292at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM29853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="68" mass="7657" checksum="5A22C528C2A7EFE9" modified="2014-04-16" version="1">MHEAMAYRNEYIQIILALSAPHCCQASTSLVGGVHWLNRVVSYFVRLDDTCLHTYQPAASNCDGTYLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q017</accession>
    <name>W6Q017_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="4">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">ubp21</name>
        <name evidence="12" type="ORF">PROQFM164_S01g003442</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="4"/>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q017"/>
    <dbReference type="STRING" id="1365484.W6Q017"/>
    <dbReference type="OMA" id="HTAHHRF"/>
    <dbReference type="OrthoDB" id="289038at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004175">
        <property type="term" value="F:endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140492">
        <property type="term" value="F:metal-dependent deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031647">
        <property type="term" value="P:regulation of protein stability"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02659">
        <property type="entry name" value="peptidase_C19C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000231">
        <property type="entry name" value="Ubiquitin C-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.210.10:FF:000011">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000005">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000215">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase 7, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002083">
        <property type="entry name" value="MATH/TRAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024729">
        <property type="entry name" value="USP7_ICP0-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029346">
        <property type="entry name" value="USP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF644">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22486">
        <property type="entry name" value="MATH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14533">
        <property type="entry name" value="USP7_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12436">
        <property type="entry name" value="USP7_ICP0_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00061">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50144">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="MATH" evidence="10">
        <location>
            <begin position="63"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="11">
        <location>
            <begin position="218"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDM29630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="1110" mass="127503" checksum="8577E37A23315F28" modified="2014-04-16" version="1">MENLAENDMLVDEYDQYPAEKTDVVVVSRSGSDEPESAPTADDHAAMMAKVLPHNTDLETLDEVYNTWRLSDWRKMERKSHGPVFRCGGSPWRILFFPYGNQTEFASFYLEHAWENGPPENWYACVQFALVLSNVNDPSIYTHHIATHRFTAEEGDWGFTRFSDLKGLFSHPWEGKSVPLVQDDEAIVTAYVRVVKDPTGVLWHSFQNYDSKKETGMVGLRNQGATCYLNSLLQSLYFTNAFRKAVYQIPTDQEASRENSAWALQRLFYNLQTNDVAVSTTELTASFGWQSSQIFEQQDVQELSRKLMERLEHKMKGTIAEKVLPDLFVGKTKTYISCINVDYESSRVEDFWDIQLNVRGNKTLDDSFRDYIQVETLEGENKYEAGQPYGLQDAKKGVIFESFPPVLHLHLKRFEYDLNLDMMAKVNDYHTFPMEFDAAPYLSESADKSESWVYQLHGVLVHSGNLDAGHYYAFLKPTKDGHWYRFDDDRVNRATDKEVLDENYGDSQQRTNGATGGRSAIRTNNAYMLVYIRKTRQDQVLLPVTKDDVPSHIEKRMSEDRAEMLRRKKEREEAHLYMNVGVLDGDSFRNHHGFDLTSNDLPAEDPALPTQYKILRTKKVSEFAQEIAEERKLKPEAIRFWVMVNRQNKTTRPDQVIRDQEMTVEEAYNKFGTKGQIFRLWMEVAPIGADGQPTPWPDNDSILIFLKNFDITTQTLTGVCSVYVHKSQKVSELAPTILSKMDWPAGTEFMLFEEIKHTMIDLMKPKQTFQQSEIQDGDIITFQRSIKESNLPPSVLYTDARQFYDYLLNRMEVQFAPVKTNEGETFYLTLSRKMTYDQFAKKVGEHLKVDETHLRFAPVMASTGKAKPFLKRNVNQNLSQILNGQYGAYGYTMHRADALYYEILDMSLTDYESKKCFKVTWLPDGVTKEEIVEILVSRSGTVADLLAALQQKLELGDEPIRIAETHSGKVYKELRSDQSVAAINEYATLYAEKIPSEELNMNADERVISVFSFDREPSRTHGIPFKFVLKPGELFAETKKRLSARTQIKGKNFEKIKFAVVPRASFSNAKYLEDGDILSDIAASADDFLGLDHPNKSRSFWGKSDGFSIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q0P0</accession>
    <name>W6Q0P0_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S01g001570</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q0P0"/>
    <dbReference type="OrthoDB" id="4340109at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM27759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="62" mass="7024" checksum="340D31E644A8FDAC" modified="2014-04-16" version="1">MTTPVALTQPIPGDRDDYIYVYFGCNIILRDATRYFDRIAYIGPGRWVGCQYAVDGGFLINT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q180</accession>
    <name>W6Q180_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Probable transposable element</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g001785</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM27974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q180"/>
    <dbReference type="STRING" id="1365484.W6Q180"/>
    <dbReference type="OMA" id="KWTPNME"/>
    <dbReference type="OrthoDB" id="3261222at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM27974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="57" mass="6326" checksum="266CFDD776566E79" modified="2014-04-16" version="1">MLQCTHTHRSNTSFFLGGKPPSDDQKWKPNLEAVRASIRFAIATADLRPLNLANECG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2024-10-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q198</accession>
    <name>W6Q198_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S02g000457</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q198"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM30308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="50" mass="5595" checksum="4C488BF959859090" modified="2014-04-16" version="1">MLSKIRGWRTRTVLRLSQPRGCRASWPAYYDETSLAWTSSIAGAIITVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q2E8</accession>
    <name>W6Q2E8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Endosomal protein P24B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">EMP24</name>
        <name evidence="11" type="ORF">PROQFM164_S02g000634</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endomembrane system</location>
            <topology evidence="7">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the EMP24/GP25L family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q2E8"/>
    <dbReference type="STRING" id="1365484.W6Q2E8"/>
    <dbReference type="OMA" id="MQVRDRN"/>
    <dbReference type="OrthoDB" id="62956at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015720">
        <property type="entry name" value="Emp24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036598">
        <property type="entry name" value="GOLD_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22811">
        <property type="entry name" value="TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01190">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101576">
        <property type="entry name" value="Supernatant protein factor (SPF), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004881238" evidence="9">
        <location>
            <begin position="22"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="10">
        <location>
            <begin position="31"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDM30485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="203" mass="23670" checksum="B47E0924FE65A7BA" modified="2014-04-16" version="1">MRFSTSAILVTALGWITAATAHTIQLKSHSRECFHESLHRDDVMTVTFQVGDREFGGSNNIEVDFWVEDPLRNRQYFKQAVASDDYSFTAQLDGKYNYCFSNEGWTSNSKEVSFNVHGIVYVPEHEMTQDPLEVEVRKLSEALTQVKDEQSYIVVRERVHRNTAESTNGRVKWWSMFQLMVVIGEGVFQVWWLKRFFEVKRVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q2S1</accession>
    <name>W6Q2S1_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S01g002325</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q2S1"/>
    <dbReference type="OrthoDB" id="5404599at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM28514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="151" mass="17314" checksum="1AA08A3F74E6D4EE" modified="2014-04-16" version="1">MADPVRESIKQVDENTWLTGDLILHSSSGPSDVSSWRNVRGYYVSFCPWSEAYFKIPRVIHETKDNTRSYLFMTRVPGRTLAVAWPTLDDAWKHHYVEEVVNICETLVGWESPMFGGVDGKNLTDHHLIDRDMCCNILCRCDLYISGVESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q344</accession>
    <name>W6Q344_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Beta-ketoacyl synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PROQFM164_S01g002430</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="8">In the C-terminal section; belongs to the NRP synthetase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1365484.W6Q344"/>
    <dbReference type="OMA" id="KQLWFAS"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901336">
        <property type="term" value="P:lactone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009403">
        <property type="term" value="P:toxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05930">
        <property type="entry name" value="A_NRPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19532">
        <property type="entry name" value="C_PKS-NRPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000019">
        <property type="entry name" value="Polyketide synthase type I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049552">
        <property type="entry name" value="PKS_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF20">
        <property type="entry name" value="HYBRID PKS-NRPS SYNTHETASE APDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21089">
        <property type="entry name" value="PKS_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="12">
        <location>
            <begin position="8"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="13">
        <location>
            <begin position="940"/>
            <end position="1242"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="11">
        <location>
            <begin position="2391"/>
            <end position="2470"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="11">
        <location>
            <begin position="3600"/>
            <end position="3680"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="9">
        <location>
            <begin position="940"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="9">
        <location>
            <begin position="1089"/>
            <end position="1242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="2491"/>
            <end position="2595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="2532"/>
            <end position="2551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="2561"/>
            <end position="2574"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="9">
        <location>
            <position position="972"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="9">
        <location>
            <position position="1148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDM28619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="4068" mass="448752" checksum="12358D0304DB5042" modified="2014-04-16" version="1">MPPLCSLPEPIAIVGSGCRFPGQSNSPSKLWELLREPKDLQTEIPPNRFNPDGFYHPDNLHHGTSNVRHSYLLEEDYRVFDAQFFGIKPAEANCIDPQHRLLLETVYESVDSAGLRLEDLRGSETAVYVGLMWGDYADMIGRDPESFPMYTSTGTARSIISNRISYFFDWHGPSMTIDTACSSSLVAVHEAVQTLRAGRSRVAVAAGSNLCLVPEPYIAESKLQMLSPTGRSRMWDAKADGYARGEGVAVVVLKTLSAALEDGDHIECLIKETGVNQDGRTNGITMPSSTAQTALIRATYANVGLDPQKKEDRCQFFEAHGTGTPTGDPLEAAAISNAFFPARGEENDRLYVGSIKTVVGHTEGTAGLAGVLKASLALQNRTIPPNLLFNQLNPKIEPFYTNLEITTTAKPWPVLPSGVPRRASVNSFGFGGTNAHAILEAYERPVVPRDRDQVNFTPFILSATSEASLTRNLTSFAEYLQENPAVNIRDVSWTLYSRRSRLAFSTIVAGATTERLRANIQARLEETDAKAPLAVRHHQSQTENPRVLGVFTGQGAQWATMGRELLKSAKVREIVQGLDLALQRLPSNDRPRWTLLKEFMTDALASRIKEAEISQPMCTAVQIILVQLLRGAGVTLDSVVGHSSGEIAAAYAAGFFSADDAICIAYYRGLCSRSARGPDGQKGAMMAVGTSLEDALELCKEPEFHGRISVAAVNSSASVTLSGDAEAIEQAKAVFDEEKKFVRILAVDKAYHSHHMRACSDQYISSLKNLNIKIGHPPPSAPVWYSSVREGNITVAGALDLADTYWSDNMVHPVLFAQAVESATAGHGPFTLAIEVGPHPALRGPTLQIIQDLLDASLDYTGTLQRGSHDLEAMSGCLGYLWQTLPPSSVDLCRYDALLSDGSQPQIVKDMPSYAWDHDRIFWYESRLWKATRSRSTPVHPLLGSRCPDGVEQEFRWRNFLSPREVPWLSGHQIQGQMVFPGAGYVSSAVEAAKNMAPNETIRLVELEDLVIRQAMIFDNESSSVETLVSITNIIHKQKDTVLANFAFYSAVGQESTAMTMNASGRLIITYGTPTPDALPVRRPSLVDMIDVPSERFYNSLDPIGYSYTGPFRALTDMKRKLGIATGFVNREPTPDSASLTLHPAMLDASIQAVLLAKSFPGDGQLWCLQVPKVIRRVAVNPSLCVSYDPMVQTAFQLDAVLTQMEASDTLGDVDIYSPDGQHTLARMEGIHAVPLEAASAASDRPFFSSMVWSPSSPDTESVTFAGKATNEDYELAYVLERVSIFYLRQLHLKFPATHQARHEGPYLGLLRFASHVSGLVENDRHRYAQRSWIHDTHAVIMRESQRFPDNVDLAVMQIIGEHMAKVIEGQSTILEYLTKDNLLSRYYEEAMGIGYFSDYLAGVVAQIVHRYPHMRILEIGAGTGSATKKVISTVGRSFSSYTFTDISNGFFENARELFSSHSGQMLFKVLDAEKDITSQGFHEESYDVIVASFVLHATSRLEHTLNNIRRLLKPGGYLVMLEVTNLEQSRLGYIFGSFPGWWLGADDGRVLSPCVTTDEWDRLLRKTGFSGIDSITPDADALPFPASAIVSQAIDPTVQFLRDPLESSGEFLDSKTDILVVGGASDAVHNVRKEILYHLKSRFDHVSVIDCLQDLSKAPTSSGYFTLNLSDLDEPVFKNMTAEALAGLKLIYERSAYLLWVTEDSRAGNIHQNQSLGFGRSMTVEMPHVQSQFLDLDSVSSSGAALIIARAILRFIGVNISDNPERANRLLWSTEQELAVIRDKEFIPRILLNNAQNLRYNASRRAIAEEVDLRSKIVTVKGNAGAYVVEHGSEYDSPATPPGSKRISVEASSLKAVRLLSGNDLYLVAGTVVATGEKVFGFAARNSSVVDIPSSWTIPSDDSPTKLLPFAAAHAVARSIVSSAHSHTALIVIEPEKVVSSALAFHASQRGLRIIFLTSDGNHMQPSWIVVHPHTHVRSLQQLLPNEPVMVLDMRPGAEGSSLTLKLRSALHSSSAFERLANFCSDTVRSSEEHIPTETIQMIATERHHDAATMRQAEQVFIPLQDISSLSLNQSAFSFIDWTSTSTVSSLIRRVDHYPFLRNDRTYWLVGLTGSLGLSLCQWLIWQGAMNVVLTSRNPNIDPTILQELRTSGARVEVYAGDVTDRESLRSVYDRICRNLPPIAGVAQGAMVLQDTMVKDMDIEAMQKVLKPKVTGSIHLDELFSHIHPLDFMIFFSSATCVTGNIGQSNYAAANMFMTALAANRKQRGLAGSVINIGAIMGVGYVTRETSEALQRNLLKSGHVWMSEGDFHTIFAEAILAGSPSSNATVELTCGLRIIRDVDEQRPLWSYSPKFQHLVVLDELSTETDGDSKRQMPLRLQLLEARTADEISKIVQESFFAKLQIMLGLHDVASSSILDKAADELGIDSLNTVEIRSWFLKELKVDIPVLRILGGATIDDILHFALDRLPTEMTPNIGAAPVPRVGEAVVRQQSEIQSRTSERKLGSIPKLASSADPVARPRPGGPGRTVSSKSLSNGQSSSTRASTTSSLVDISRGEDTSSGSFSIIETPSFSEDEHNLPLPDNPSQANLLKQPGDSVHSVLRKEPLSFAQSRFWFLRLYLEDQTTFNITCSLRIQGAFSVDALERAVQGVGQRHEALRTCFSAEDGESPTQIILPHSTLSLERKTYHTMSEVEATMREVKNHIYDLEHGQLMRVLLLCPAVLATPLVHFLIIGYHHINMDGVSLEVILSELQNTYEGRSLSTRVLQYPDYAAKQRQQRNNGSWNEDLAFWRERFPEPPADFPLLPFACVSDRQALLRYGHHRVQQRLNPSLGRQIRQFCQSVKCTPSHFYLAAFQALLCRLAETQDICIGMADANRIQVEAADSVGPYLNLLALPLHYDANTPFVELTRSARKKVYSSLAHSQVPFDILLSELKVPRSPSHNPLFQVFMDYRQDVREKRQFGECLFEGLDYEMGRTSYDVALDIVDKVEGEPLVILGLQQSLYSTEAAETLLNAFLNMVAVFANDPSTPVGQASIFAVKDVQRSLALSQGPTVPSRWPATLPHRIDTMVQRFPKKLALKDGLNNRFTFEEMSQRIDSIAFALLGANVSRGQRVGVFQHPTADWICSMLAILRVGATYVPLDLRLEIPRLKSICDDCKPMVLLVDNETKDQVDELGCSNALSMNIYDLPMSFPIPVVNRAVLEDPAVIFYTSGSTGAPKGIALTHENLRVNVEGNQEEFRLWPHDHLLQQIAFSFDFSVWQVFMALANAASLFIAPLSKRGDPVALVESILTEGITVAGATPSEYHSWFMHGDLSGLKKSKWRTAVSAGEPMTSSMIHDFQELNKRDLRLFNGYGPTEASMSSNKLQVPYLRSKTQSPQEWMHRGSVVAGYTAPNYSIYIVDEALNPVPVGIPGQILIGGPGIAHGYLNNEDLSRSRFMEDRFATAEQKAQGWRRVHLTGDRGRIRPDGQLQIEGRINGDTQVKLRGYRVDLRDIETVILQSSQGMLKEAVVTLYTGSNTNTELLVAYVIFLAGYPVEQRKQSLRELSKSLPLPRYMWPSMVLPVDDMPVTAHGKLDRKALSTRSLPQTEAESVGLTSQLTGTEARLVELWRSVISKDVIAIHGLEPESDFFAVGGNSMLLVELQRQIKVEFRTEIPLVQLFGATTVQKMALLLDPSTDAAKIAAGPVATTAAAPIIWEQEIQLPDQLQLSTPTAPTTRLENLRGLCIVLTGATGFIGRALLQRLVEDPAVATVHCIAVRVTSTRRPPLVTAGKIIVHYGDLTLPRLGLVEAQATAIFNDADAVIHNGADVSFLKNYPALRRANVDSTIELLQLAWPRQVPVHYVSTSGVANFTQSSTFAEVSAASVLPPTDGSQGYLSSKWASERVLEEANRKADFPVWIHRPSSVTGEGSSPLDLMDNLLEFSRKLRAVPLPAKSSWQGYLDFVPVEQVARDIVREILAPRDPSPLNQVRYLHHLGEQIPLHGIQRYLEKGTGASYRALPMGEWLKEAQQAGLSALLVEYLGQMDRPDVKVVFPRLVARPRLTSGGLTRQGSWVSKGVAMLLTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q3C5</accession>
    <name>W6Q3C5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Bile acid:sodium symporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PROQFM164_S02g000620</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cell membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the arsenical resistance-3 (ACR3) (TC 2.A.59) family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q3C5"/>
    <dbReference type="STRING" id="1365484.W6Q3C5"/>
    <dbReference type="OMA" id="GGNKEYG"/>
    <dbReference type="OrthoDB" id="187348at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015104">
        <property type="term" value="F:antimonite transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015105">
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:response to arsenic-containing substance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Arsenite transporter, ACR3 family"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004706">
        <property type="entry name" value="Arsenical-R_Acr3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002657">
        <property type="entry name" value="BilAc:Na_symport/Acr3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00832">
        <property type="entry name" value="acr3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43057:SF1">
        <property type="entry name" value="ARSENICAL-RESISTANCE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43057">
        <property type="entry name" value="ARSENITE EFFLUX TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01758">
        <property type="entry name" value="SBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005508">
        <property type="entry name" value="Acr3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0059">Arsenical resistance</keyword>
    <keyword evidence="4 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="47"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="122"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="174"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="210"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="244"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="285"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="341"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="19"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR005508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDM30471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="372" mass="40931" checksum="AA2E7AE08A7E2CD0" modified="2014-04-16" version="1">MTSIRPQTCTSSPPNDQIKTCDIEKQRETSSPDEPQKKESMFSSLGILDRFLAIWIFLAMAIGIILGNFVPSTGPALQRGKFVGVSVPIAVGLLVMMYPILCKIRFESLHHVLRAKDIWIQIAFSIFLNWIIAPFLMLALAWAFLPDEPELRQGLIIVLVWTGLAGGDSEYCAILVALNSVLQMVLFAPMGVFFISVISGDPVTFEYSTAAKSVAVFLGIPLGAAIVTRFVLRRISAKWYDETFLKWISPWSLIGLLFTILVLFASQGRHVVHQIVSVVRVAAPLIVYFLIIFFVTLLVAYKLGFGYRLATVQSFTAASNNFELAIAVAVAMFGADSNQALAATVGPLIEVPVLLGLVYAVKLIARRVSWND</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q3D2</accession>
    <name>W6Q3D2_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Leucine-rich repeat, ribonuclease inhibitor subtype</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PROQFM164_S01g002485</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q3D2"/>
    <dbReference type="STRING" id="1365484.W6Q3D2"/>
    <dbReference type="OMA" id="ECPSLCH"/>
    <dbReference type="OrthoDB" id="8436363at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006913">
        <property type="term" value="P:nucleocytoplasmic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027038">
        <property type="entry name" value="RanGap"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113">
        <property type="entry name" value="RAN GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113:SF12">
        <property type="entry name" value="RAN GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="247"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="292"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="925"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1067"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1182"/>
            <end position="1208"/>
        </location>
    </feature>
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        <location>
            <begin position="114"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="160"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="172"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="256"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="299"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="318"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="340"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="925"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="939"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1070"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1188"/>
            <end position="1208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDM28674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="1208" mass="132986" checksum="A2DDB42576D04A07" modified="2014-04-16" version="1">MEGVQTVDVSWLHHSQKDHLSRTKSVSASDKPGTQAEPTTPQPKSHRRSRSNSNPPPRPTPAPSTAEPKPAPQNNVAPVQAKPQPVEKSEEQKPSTPSPAPRKTDPKPIGRRNSWISSLSSKFSSGTTPPSQPSLKAPPASPKTTPTIDTHNPFGAAYSLRDREEERKEESFTSTSPKSPSFIHNALRKFSSNSGGLPKLNPNVVVSQRRVMNVDKNRQRCKIADLNQAKLNRVAFCVDVEIAGVSHRDDDEGAPPTNQLRQPQPLTEATNHKSKKADLKLKDQDEAGALKHPQATLADKNSASSTPAPATGDAKAQSSSTPTNTTSSKPSNDPAPNGEVIDHTRKQERKKRSEAERKERKERKRRQAVANGIIPLQLDAENDDDEEYSQGPAPGVTRPKTQSHPTTDPVRIYRRCCQLRETPVLKRVVDEISKPSSTLAESPGTVAALDLSNFPMTSQDLTTFSDWLAVVPVRELILENCALTDTSVRAILSALLATKTVEQMRYRRRRLRRPESSDSTEQERYGVVEKLSLKDNPKIGREGWRHMSLFVHLSKSLKSIDLSGIPFPRGQVAVDVRGPTSQSQPTADVRMVFANALAERFAGDHLEELLLSECYPSVDAVKQICQATTKMGLRRLGFANNGLTREGLEHVIEYLKAGQCEGLDLGGNAIKDDLDLLTAAIEPETPLYALSLADCSLNPSVISPLLQSLAQIHNLRFIDFSHNRELFSSQPSALGAFRRFLPKMPSLKRFHLADVNLSPDHVIGLAEVLPECPSLCHLNILENQQIVELASTTDPVAQEEACAVYASMMTAVRVSRTIIAVDIDVPSAENNEVVKALGSQIVAYSLRNLEGGAIAVELPGSTSSLEDIPYPDILQHIVGHSVISEEPYDDDDDAAPDEDYVIGGTGVVKALGVCLGNLDQQGLDLLGEQSLPPSGTTTPRRRRSRAVPTKRPRDMSKNLLESARNIRVRIQSALIREDRAGNDANYGRLQFLDVTLHKMIQRFEDEYPETRIVPQLPPTVTVPDTISQHSGDDDGSSSFFASGNLNSSQLEENCFDEEDTDQYAVRHSRTSSVTSLHSRAMTSQEGHIHRIGQNLRRDFLNPSLVPGEDDEPFEYEDDSSHIAALRQKLDILHDEQSLSEFDDFDADVAFNHLGTTVDELYAAQQQDTEAFERFKQAQIAAQINSGIRPRDQVEPRTGRNEPESKSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q3U8</accession>
    <name>W6Q3U8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S02g001175</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q3U8"/>
    <dbReference type="STRING" id="1365484.W6Q3U8"/>
    <dbReference type="OMA" id="HIMKADR"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090374">
        <property type="term" value="P:oligopeptide export from mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF1">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B MEMBER 10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM31025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="79" mass="8910" checksum="64FAB86C9712832E" modified="2014-04-16" version="1">MNEPTGGLDEHTERLATELLRERLIGRTIISIAHQINTVMDSDLVMVIDQGTVSEMGEPQELLSRKGMFWQLFRGIKGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q4B1</accession>
    <name>W6Q4B1_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Autophagy-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S02g001613</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Vacuolar effluxer which mediate the efflux of amino acids resulting from autophagic degradation. The release of autophagic amino acids allows the maintenance of protein synthesis and viability during nitrogen starvation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATG22 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q4B1"/>
    <dbReference type="STRING" id="1365484.W6Q4B1"/>
    <dbReference type="OrthoDB" id="4956953at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024671">
        <property type="entry name" value="Atg22-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11700">
        <property type="entry name" value="ATG22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="1" id="KW-0072">Autophagy</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <keyword evidence="1" id="KW-0926">Vacuole</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM31463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="117" mass="12551" checksum="72C77495C396F632" modified="2014-04-16" version="1">MADVRDSVEGNVSGDEEDVDKQGLRATEHDLEQANSKAVFNSKKALWGFLVLCYSTGPTSSMVSNYVTAAILSAANLLGHQAGSNKPCSRRGTNISCLVEFGGGEIDYNSYTCVSWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q4G2</accession>
    <name>W6Q4G2_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S02g000976</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q4G2"/>
    <dbReference type="STRING" id="1365484.W6Q4G2"/>
    <dbReference type="OMA" id="MDISYSY"/>
    <dbReference type="OrthoDB" id="4991875at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40640">
        <property type="entry name" value="ANCHORED GLYCOPROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04860)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40640:SF1">
        <property type="entry name" value="ANCHORED GLYCOPROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04860)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004881272" evidence="2">
        <location>
            <begin position="18"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="161"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM30826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="225" mass="22018" checksum="AA7CF773CCDEF273" modified="2014-04-16" version="1">MRLQSLALLAGATTALAVQTTSLFLPGFDEQRIDGKVIGTSGSMTKYYLKCAPNVDADECGLPFDGMTVAQGPSTVSLAYSTEDVTISESCKFDSISATCGATVVTDGSTSSWHSAIAISEIPGGVYMPVTITATGTDGSSATTGAAVSASTAASTSAATMTTSASTSDSTAAGTSTGTSTGTSTDSSAAATSQTETGNAAMPMITGNARWAAGGVAAALALAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q4K2</accession>
    <name>W6Q4K2_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PROQFM164_S01g002920</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM164</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q4K2"/>
    <dbReference type="STRING" id="1365484.W6Q4K2"/>
    <dbReference type="OMA" id="HYWVSTI"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11058">
        <property type="entry name" value="CYP60B-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF230">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="438"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDM29109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="502" mass="57579" checksum="E934EB43982177BC" modified="2014-04-16" version="1">MLTTIFLLAILFFCIFLLNIIRALYFHPLSNLPGPKIWVAFPITRFIALSQGRLETKMRDFHKRYGEVVRFGPNEVSFITAQAWKDIYGHGHRQLPKVLHSTSNPSDIISANDADHSRLRMSLAHAFSAKGLQSQEPIITKYVDLLIEKLRIIAASPIPEADMVKWYNLTTFDILGDLAFGEPFGGLESSKYHYWVSTIFQAIRGMSLVSFKDAYPFLFRILSLFVDSKSLMSARKRQIEFSRATIQKRLQFQGDRECTDFIDSMLRQRGDSNNEITEEELEANSNVLVIGGSETTATLLSGITYWLLRTPHAMEKLTREIRSAMKTEKHITISSTANLPYMLACLKEALRIYPPAPSGQQRITLGPGPTNISGYVVPRNTKVSVHQYAAYQSPMNFYAPDKFMPERWLEDARDDLSSPFYNDNRDILQPFSVGPRNCIGRELAYSESRVILARVLWSFDLKFHEKSGEWDKQRSYLLWEKPPLICKLKLSDKDIWRTAHET</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q4T1</accession>
    <name>W6Q4T1_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed RNA polymerases I, II, and III subunit RPABC5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">RPB10</name>
        <name evidence="8" type="ORF">PROQFM164_S01g003011</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the archaeal Rpo10/eukaryotic RPB10 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q4T1"/>
    <dbReference type="STRING" id="1365484.W6Q4T1"/>
    <dbReference type="OMA" id="YCCRRMF"/>
    <dbReference type="OrthoDB" id="10258858at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:RNA polymerase II, core complex"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006360">
        <property type="term" value="P:transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000024">
        <property type="entry name" value="DNA-directed RNA polymerases I, II, and III subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00250">
        <property type="entry name" value="RNApol_arch_Rpo10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023580">
        <property type="entry name" value="RNA_pol_su_RPB10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020789">
        <property type="entry name" value="RNA_pol_suN_Zn-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000268">
        <property type="entry name" value="RPABC5/Rpb10"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003089">
        <property type="entry name" value="PRK04016.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23431:SF3">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23431">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC5 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01194">
        <property type="entry name" value="RNA_pol_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005653">
        <property type="entry name" value="RNA_pol_N/8_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46924">
        <property type="entry name" value="RNA polymerase subunit RPB10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01112">
        <property type="entry name" value="RNA_POL_N_8KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM29199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="74" mass="8581" checksum="90FB1290EB3BCE98" modified="2014-04-16" version="1">MIIPVRCFSCGKVVGDLWERYLQLLDDGVPDGDAMDQLGCRRYCCRRMVMTHVDLIEKLLRYNSAEKDRSKAQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q531</accession>
    <name>W6Q531_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Nucleotide-binding, alpha-beta plait</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PROQFM164_S01g003091</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q531"/>
    <dbReference type="STRING" id="1365484.W6Q531"/>
    <dbReference type="OMA" id="GSWHVDY"/>
    <dbReference type="OrthoDB" id="2573941at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12411">
        <property type="entry name" value="RRM_ist3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051847">
        <property type="entry name" value="RNA_proc/Spliceosome_comp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045844">
        <property type="entry name" value="RRM_Ist3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45880">
        <property type="entry name" value="RNA-BINDING MOTIF PROTEIN, X-LINKED 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45880:SF1">
        <property type="entry name" value="RNA-BINDING MOTIF PROTEIN, X-LINKED 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="33"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="112"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="190"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="210"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="227"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="260"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDM29279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="278" mass="33183" checksum="8912CBA7D2035A78" modified="2014-04-16" version="1">MNSIRQVQALNKRELEHAIPPEASWHADYRDTAYIYIGGLPFDLSEGDIIAIFSQYGEPVHVNLVRDKETGKSKGFAFLKYEDQRSTDLAVDNLGGATVMGRLLRVDHARYKRKDDEEEQDNVAKLMGDPGVSENKSKEDDRRRGTAIEERRPMLKEERELEELIRNHDEEDPMKEFLIEEKKEEIATAIQLWNSTKKSSRRRDDSRERSSRHHRRHRSRSPRERRHRDDRSMDRERRSRRRSSERGEKSKRDRSPRKSRSPEPRRHRSDRDRHDRRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q554</accession>
    <name>W6Q554_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S01g003121</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q554"/>
    <dbReference type="STRING" id="1365484.W6Q554"/>
    <dbReference type="OMA" id="DFRRQFI"/>
    <dbReference type="OrthoDB" id="1922977at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM29309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="59" mass="6871" checksum="4FA3DD384FA33305" modified="2014-04-16" version="1">MGSVREGQTEEEKEKYLAGLKEIINDLRRDKVKDFNTVASEIAAYRRRFLQDPSRVLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q5Q0</accession>
    <name>W6Q5Q0_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Probable endonuclease LCL3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Probable endonuclease lcl3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PROQFM164_S01g003376</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q5Q0"/>
    <dbReference type="STRING" id="1365484.W6Q5Q0"/>
    <dbReference type="OMA" id="ARCADHH"/>
    <dbReference type="OrthoDB" id="10023235at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031332">
        <property type="term" value="C:RNAi effector complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031047">
        <property type="term" value="P:regulatory ncRNA-mediated gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00175">
        <property type="entry name" value="SNc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.90:FF:000010">
        <property type="entry name" value="Ribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.140:FF:000018">
        <property type="entry name" value="Serine/threonine-protein kinase 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.90:FF:000001">
        <property type="entry name" value="Staphylococcal nuclease domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.90:FF:000019">
        <property type="entry name" value="Transcription factor (Snd1/p100), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.90:FF:000030">
        <property type="entry name" value="Transcription factor (Snd1/p100), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.90">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016685">
        <property type="entry name" value="Silence_cplx_Nase-comp_TudorSN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035437">
        <property type="entry name" value="SNase_OB-fold_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016071">
        <property type="entry name" value="Staphylococal_nuclease_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002999">
        <property type="entry name" value="Tudor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12302">
        <property type="entry name" value="EBNA2 BINDING PROTEIN P100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12302:SF2">
        <property type="entry name" value="STAPHYLOCOCCAL NUCLEASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00565">
        <property type="entry name" value="SNase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00567">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017179">
        <property type="entry name" value="RISC-Tudor-SN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00318">
        <property type="entry name" value="SNc"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00333">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50199">
        <property type="entry name" value="Staphylococcal nuclease"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50830">
        <property type="entry name" value="TNASE_3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50304">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="TNase-like" evidence="10">
        <location>
            <begin position="1"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="TNase-like" evidence="10">
        <location>
            <begin position="168"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="TNase-like" evidence="10">
        <location>
            <begin position="319"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="TNase-like" evidence="10">
        <location>
            <begin position="485"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="domain" description="Tudor" evidence="9">
        <location>
            <begin position="704"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="625"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="633"/>
            <end position="642"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR017179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDM29564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="887" mass="97579" checksum="460522E9F3CD5531" modified="2014-04-16" version="1">MPFEARVKSVLSGDTVVLSHITNPSQERVLSLAYVSAPRLRREGDEPYAFQSREFLRELLVGKVIQFHVVYTIPSGAKRDYGTIKLPGFDASLPDISVQEGWTRVREEAGKRGDESEETIGLLDRLRALQSLAQEEGKGTWAGGDDGHIDTSYELIGARDLVKRNLGHQLEGIIEKVLNGDRVVLRLLLKPQEHIQTVIAVAGIRAPSAKRTTADGKETAAEPFGDEALQFVEERLLQRKVKVSLLGVTPQGQIVATLLHPNGNISRFLLEAGLARCQDHHSTLLGSDMALLRQAELTAKADRKGLWVSHTGPTTAGAAAVDYVVTRVLNADTLFIRNKAGQEKKISLASIRQPKPSDPKQSPFAAEAKEFLRKRVIAKHVLVTVNGKKPANEGYEEREVATVVHGNTNVGLALVEAGYASVIRHRMDDADRSPDYDALLAAEADAQKEGRGMWTSKPPKAKQVVDYSESVQKAKLELGILQRQKRVPAVVDFVKSGSRFTVLVPRDNAKLTLVLSGIRAPRSSRGPSDAGEPFGQEAHDLANRRCMQRDVEIDVETIDKVGGFIGSLYINKENFTTVLLEEGFATVHAYSAEQSGHAAEYFAAEQRAKDARKGLWHDWDPAKEAAEAEEAEAANGAGTGAESDAAPAQRRKDYRDVMVTYIDPTSAKLKLQQIGTGTNALTELMSAFRKFHINKANDTPLPGPPKAGDWVAAQFTEDGAWYRAKVRRNDREKEQAEVVYIDFGNSEILPWASLRPLTQPQFSSQTLRPQAIDAVLSLLQFPTSEDYLEDAVGFVGDQTFDRQLVANVDHVDQDGTLHVTLLDPSASKNLDNSINADIIQEGLAMVPRKLKAWERASVDTLSNLRALEDEAKAERRGIWEYGDLTED</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q5X2</accession>
    <name>W6Q5X2_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HypA-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S01g003456</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q5X2"/>
    <dbReference type="STRING" id="1365484.W6Q5X2"/>
    <dbReference type="OMA" id="KFDFFYI"/>
    <dbReference type="OrthoDB" id="10004862at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025337">
        <property type="entry name" value="Questin_oxidase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35870">
        <property type="entry name" value="PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G03330)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35870:SF1">
        <property type="entry name" value="PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G03330)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14027">
        <property type="entry name" value="Questin_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM29644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="447" mass="51001" checksum="2A537710049A0217" modified="2014-04-16" version="1">MATATKIHLSPATDSGIYSFNVREDTARTVSELLQEDLEIHHVFFNNERFHNHIPHELLTIYALGASPEEVKTCYDRNKRYQRPALPANQDIVQSMHDVAKFKECSGKEENYPHYLAFFQQEIDAKGVPDVLNEYLFAEDERAESMMCRVFAGLIHPFIQLGFGIEFNQPAIVAQGLAQIAVHDDWLGRAYFLPAEKMAGGIGKPGQKSLFQLINEIRADKTLVESVQWSDSNKIKDGVLHRAPEQMLKYASQFTVSKDQVHGRLADMTNTVEAIAEFISSVYYTSAAQRPTKEMWLDFFLIHCVNSSIFFSKIIELPFMTQRSKLRMLEWKGRIELLMYTSRGTPDLLLDEVANYSPKDNWSQLFARSIAHPDDDGHLAKLVRALAHGQKVCQVYERTHPEMRIKGNMWLSVGNIAVDSTVEEGGRPMWVRSTGFDEAWESQRAHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q669</accession>
    <name>W6Q669_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">ATP-dependent RNA helicase FAL1</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">ATP-dependent RNA helicase fal1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="primary">fal1</name>
        <name evidence="21" type="ORF">PROQFM164_S01g003562</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">ATP-dependent RNA helicase involved in 40S ribosomal subunit biogenesis. Required for the processing and cleavage of 35S pre-rRNA at sites A0, A1, and A2, leading to mature 18S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the DEAD box helicase family. DDX48/FAL1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q669"/>
    <dbReference type="STRING" id="1365484.W6Q669"/>
    <dbReference type="OMA" id="TRFHDFK"/>
    <dbReference type="OrthoDB" id="10265785at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18045">
        <property type="entry name" value="DEADc_EIF4AIII_DDX48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000031">
        <property type="entry name" value="Eukaryotic initiation factor 4A-III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000498">
        <property type="entry name" value="Eukaryotic initiation factor 4A-III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 17 21" id="KW-0347">Helicase</keyword>
    <keyword evidence="6 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="20">
        <location>
            <begin position="25"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="18">
        <location>
            <begin position="56"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="19">
        <location>
            <begin position="237"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="16">
        <location>
            <begin position="25"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00040655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00040908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="CDM29749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="399" mass="45478" checksum="732C3B31AEB8B51C" modified="2014-04-16" version="1">MADGIDRRAEERMEFNTSKEVTVAPTFEDMHLKESLLRGVYAYGYESPSAVQSRAIVQICKGRDTIAQAQSGTGKTATFAISTLQIIDTVVRETQALVLSPTRELATQIQSVIMALGDYMNVQCHACIGGTNVGEDIRKLEYGQHVVSGTPGRVADMIRRRNLRTRHIKMLVLDEADELLNRGFREQIYDVYRYLPPATQVVVVSATLPYDVLDMTTKFMTDPVRVLVKRDELTLEGIKQYFIAVEKEEWKFDTLCDLYDTLTITQAVIFCNTRRKVDWLADKMREANFTVSSMHGEMPQKERDSIMQDFRQGNSRVLISTDVWARGIDVQQVSLVINYDLPTNRENYIHRIGRSGRFGRKGVAINFVTTDDVRILRDIELYYSTQIDEMPMNVADLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q6B5</accession>
    <name>W6Q6B5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein family UPF0016</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PROQFM164_S02g002011</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GDT1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q6B5"/>
    <dbReference type="STRING" id="1365484.W6Q6B5"/>
    <dbReference type="OMA" id="YWWVTIG"/>
    <dbReference type="OrthoDB" id="442680at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015085">
        <property type="term" value="F:calcium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005384">
        <property type="term" value="F:manganese ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032468">
        <property type="term" value="P:Golgi calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032472">
        <property type="term" value="P:Golgi calcium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001727">
        <property type="entry name" value="GDT1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049555">
        <property type="entry name" value="GDT1-like_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12608:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 165"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12608">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN HTP-1 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01169">
        <property type="entry name" value="GDT1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01214">
        <property type="entry name" value="UPF0016"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004881815" evidence="8">
        <location>
            <begin position="22"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="278"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="308"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="340"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="450"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="491"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="524"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="55"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="362"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="126"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="203"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="223"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="238"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="256"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="371"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="425"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM31860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="546" mass="57668" checksum="4D579FE26C44AD27" modified="2014-04-16" version="1">MKINQSPFLLFLLPAISAVLADTYNDNIDSKVSRETVGNNARLVDSDIVASNVAKGAPDVPVDGKDGRPHAGPWVETNADRDRTGLQGGDDVDPVSVKYDTNIPSSEHLSTEEGKMIPHSNGGVMDDPHRAGPKEGTRGTEGGVSEKGKESQLASEKVPGGPKEAPPLPHSETKKLGPDSDDTTTGGGSRSAEGPGSLGMLGKPDDLPEKPHDIPHPKSPGTAKEDPIGLGHDKVTPGSSSSSSSSSSSSSLGHGHGHDHDHDHDSGIHDAGSSLHSLVFSFTMILVSEIGDKTFLVAALMAMRHPRLVVFSAAFSALVMMTVLSAVLGHAVPTLIPKTFTKFLAAILFLIFGAKMLKEGREMSPDEGVGEEMREVEAELEEKEHEQLRMNRRRSSVTPHNLEAGRAGGRPKTRGSGNRLPSPPESLSSSSSRGSSPQPRQRLNNVVSGLSNLFSLLLSPAWVQTFVMTFLGEWGDRSQIATITMAAGQDYWWVTIGASAGHGICTAAAVLGGRAIAGRVSMRVVTLGGAVAFLLFGVIYFIEAIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q6C2</accession>
    <name>W6Q6C2_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MINDY deubiquitinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S01g003632</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM29819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q6C2"/>
    <dbReference type="STRING" id="1365484.W6Q6C2"/>
    <dbReference type="OMA" id="KDRNKDC"/>
    <dbReference type="OrthoDB" id="10261212at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016807">
        <property type="term" value="F:cysteine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990380">
        <property type="term" value="F:K48-linked deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071108">
        <property type="term" value="P:protein K48-linked deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007518">
        <property type="entry name" value="MINDY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033979">
        <property type="entry name" value="MINDY_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18063">
        <property type="entry name" value="NF-E2 INDUCIBLE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18063:SF6">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04424">
        <property type="entry name" value="MINDY_DUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MINDY deubiquitinase" evidence="2">
        <location>
            <begin position="393"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="281"/>
            <end position="313"/>
        </location>
    </feature>
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        <location>
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            <end position="714"/>
        </location>
    </feature>
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        <location>
            <begin position="730"/>
            <end position="880"/>
        </location>
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        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
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        <location>
            <begin position="288"/>
            <end position="313"/>
        </location>
    </feature>
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        <location>
            <begin position="676"/>
            <end position="689"/>
        </location>
    </feature>
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            <begin position="731"/>
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        <location>
            <begin position="749"/>
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            <begin position="796"/>
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        <location>
            <begin position="864"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04424"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CDM29819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="880" mass="96496" checksum="B43408D8E33BE079" modified="2014-04-16" version="1">MGLRKQPPPRLENISKSNVRSDARSSKSPNSASFHRPIRLNRFPSGDPIYSPDLNTSPAFDLMPLEEAQRSPVGSPTSQPPSSWPDNNRRPEDGRSGQYNQYEGAYNEPANTNGHWVPPTLTAGQQLGAAENVWRSTTDSGRASTGELSVQLQSNNPFLKPRPAEHTQDLLDRNEWGRDSHATSNSDALSQSEGYIPMTARLSLLDEPEQESPWTEAPRPQSNSQQRPVLGGHHLDDNSPWDSQQSAKVPVPQGVYLQGEQSNPYAPAVAVQPSGLSDWETYAGQQYKPPSNSGRLGSDAGINTPSVALSNRTSATSHELIDFGELSATGNSVGETRFPAASTAYSEPAANGARSLSEKQDLAAPVIQQLQQPQASPILSPAEAARQKEQRSETYTIRHIRWTDQSGQLLESPILVQNQNGPCPLLALINALVLRANPNAHPPIVRALSTREQISLGLLIEAMFEELTTCLGPDEEFPDIEALTQFLTMLHTGMNVNPRLTMNSTEGFGTFLETSDLGLYSTFGIPLIHGWLASWSSPTHAAMSRTAQYYEDIQMLPFRRHEFEERVARGEALEPAEENIMADIQTIQRFVEIENATQLSPFGLTQLSTKLTPGSVSILFRNDHFSTLYKHPQSHQLYTLVTDAGYAGHAEVVWESLVDVTGFNTEYYSGDFRPVGAGPSAPSGPDPAVLQASNEPATHSPEANEGSKSPELTQEQSDADYAYALSLQFQEEERRENARNEQARDRRTSAPSNYSNRPLPSPRLSNVPNRPLPSPRLSNVPNRSSSIANTIGSRPSPQPQHGPDPEDPNAPPPPYEQAAASGPRCSPPDIRPYGRAAGNQYPGNRNPRNRTSQSSHRPRPPVRAGDHNIETERNKECIVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q706</accession>
    <name>W6Q706_PENRF</name>
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        <recommendedName>
            <fullName evidence="1">Repressor of RNA polymerase III transcription MAF1</fullName>
        </recommendedName>
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        <name evidence="3" type="ORF">PROQFM164_S02g002296</name>
    </gene>
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        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
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        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mediator of diverse signals that repress RNA polymerase III transcription. Inhibits the de novo assembly of TFIIIB onto DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MAF1 family.</text>
    </comment>
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        <property type="protein sequence ID" value="CDM32145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OMA" id="GCDLWTV"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000994">
        <property type="term" value="F:RNA polymerase III core binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016480">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1000.50:FF:000004">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Repressor of RNA polymerase III transcription Maf1"/>
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    </dbReference>
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        <property type="entry name" value="Maf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038564">
        <property type="entry name" value="Maf1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22504">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR22504:SF0">
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
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        <location>
            <begin position="278"/>
            <end position="297"/>
        </location>
    </feature>
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        <location>
            <begin position="304"/>
            <end position="330"/>
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    </feature>
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        <location>
            <begin position="286"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR037240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM32145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="330" mass="37372" checksum="DE6F0F6918536BA1" modified="2014-04-16" version="1">MKFLPLPDFEDVTSSLNFDTTDCHIVGGCDIYTTKAARSDRKLYNHIEQSLEAQYESVLRFSASLSPPNAHDAAEALNLSRSSPFGPLSDHSSRRTFAYLIATLNASHPDYDFSHVLRPTDFRRERNLKRVMNTVDSTLLNLRPRENINLSPASPATLSGSYTAGSSSAWGPRVWKTIDEHMSLKECSIYSYSPEEDPSDADDGAIWSLHFFFFNPIRKRVCYIFLRAIPILSHTPDEMATTPTGKRTYDDGYLTPDLSSSKRAKFWFGERARSNLISSDSDDEMDRPPKTIRTTDDYDTYVISDDEENMPTNRRGVRAMSEEIADSMEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q7H7</accession>
    <name>W6Q7H7_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nucleotide-binding, alpha-beta plait</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S02g002446</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
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        </lineage>
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        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
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            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q7H7"/>
    <dbReference type="STRING" id="1365484.W6Q7H7"/>
    <dbReference type="OMA" id="AFQHRKP"/>
    <dbReference type="OrthoDB" id="410044at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="117"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="23"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="269"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="558"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="862"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="34"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="73"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
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            <begin position="269"/>
            <end position="281"/>
        </location>
    </feature>
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        <location>
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            <end position="309"/>
        </location>
    </feature>
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        <location>
            <begin position="320"/>
            <end position="332"/>
        </location>
    </feature>
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        <location>
            <begin position="348"/>
            <end position="398"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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            <begin position="565"/>
            <end position="578"/>
        </location>
    </feature>
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        <location>
            <begin position="688"/>
            <end position="701"/>
        </location>
    </feature>
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        <location>
            <begin position="711"/>
            <end position="720"/>
        </location>
    </feature>
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        <location>
            <begin position="724"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="759"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="873"/>
            <end position="885"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM32295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="885" mass="97144" checksum="03135CFC82585DC8" modified="2014-04-16" version="1">MAMHYVEQNISAPVSWYSAPEPTIIWQDPHDTGSESSAFESGSSKPSTPEQPDARSVEPFRPVETVQPVELVTPKETKPGDKKKPGEGNNPVYMPREDRLNQTPTKGNAQGLFLPACCVFVGNLSIKVSPEKLEEDLTEMISTFGRCHVKIKLSQGVKKLPVGFVQFEDTKAANAALKQNGNLMLHNRVLRLESSKARRTANFGRLSDAPVEKADVVAALRGRGSLESIAIEHFVNQDGEDSTFGVVTFAYPDDYADALQHFQNNPDYYMTRSTMDPNDQLPQDYPAGHRSSNQPPANRGNQQRYNNTGRRPFHRPWYSGGNNNNNRGGFRNAPGPAPRQQNTSFANHGHSQSFNGQGHSSHGSFSQNYSGNGFPQNNFNQGYPSPNPNYNQNFPGNNFHPNYQGNFPNYPNQNFVAAGPFPNAPVLFNQMQMPEGPPPPYHAEYTAMQNPGFPVFLGNQSYQPPNTLAPMMTPVQAVAGPVPGAVPGAVPGAVPRRRRLPPRPDCPLIVSSQPQFDTEQHLQLYYEPYPGNEPVVNMQPGWTGHTCFVQPDYNQPCPPDAYPHSRQSSMESQHNTCSPPRVNESESILTQTKFHIPEVERGRPLVRPRHPNTDGGFDTAPVSAPAKAQRDSSSVKPLDGSSGRASKSTDAQVEPALPMRKPIKSENKATEPETELNPPQPESTCGPSHDEKKKELMDEIKPPLSIDTNEESAGSSSEAGPKTPDTEQSRESAKLQTPAKAGLVKSAGSKTPDSAETLKPADKGTSDKGKSPEVATSTPTKSGSKRLEPAVPDSKHLLARHAFQHRKPLKKKYQPKTDTGKTVEQYTREINAQRASVDPDSRVPEHILQEVIQELENERRENIRKSLGLGPSAKSSMDSGTSKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2024-10-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q7Q7</accession>
    <name>W6Q7Q7_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S02g002197</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q7Q7"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM32046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="52" mass="6036" checksum="5974228902C609AC" modified="2014-04-16" version="1">MDAAIRARSPSEIQRQLLNLASSFAPSFQQDAAYIWLTYHMSCKSPYWDGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2024-10-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q953</accession>
    <name>W6Q953_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">PROQFM164_S02g003081</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q953"/>
    <dbReference type="Proteomes" id="UP000030686">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM32930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="108" mass="12364" checksum="420D20E988F7DE5D" modified="2014-04-16" version="1">MKKKSGDEISFPRTFSGKWKTGKCREFQESKTRYSPSDLPMLTHTSRCKYHIPLKLHRNYAGYAMENHHTPECTLQTIQGKPSCDHNTWGLCGSGVTKGMRSRKSGRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q988</accession>
    <name>W6Q988_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S01g000116</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM26307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1365484.W6Q988"/>
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    <dbReference type="OrthoDB" id="118256at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Allergen_Asp_f_4"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004879660" evidence="2">
        <location>
            <begin position="20"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM26307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="486" mass="52370" checksum="95D6C458F3B6C468" modified="2014-04-16" version="1">MGRVSIHVLLAGFVGYVFAGIHHPAHGHRHHPRRLMPPVEDLEPRNMAWENVNTSLDDFVVESITITTTTTVFGNCAPTNTIHSTLTLVRNRPEAASYMTDHPVHGLARPEAYEEHWHQGEPKPEPVLPAPTNTRSAQLQFTQPNTPAPRPTEPEETTTIFKTHTITKTATNTVKVTVYPGASPSPLRDTLPDNPSKAEKATLLAETLPKGSLEEEKAVPAKRPSPPSHKNNGPINAVLDLPSEILPGVPVVNQILPGPKPDNPTAVNWTATPPNGQFSTNGFGGRTLPKGEGTEILYQGNVGNPWGSNIINISPTEAHAYKYVAQFTGPNDEPWTVVVWNKVGPDGKLTGWYGHSALTFTIAPGETRYVAFDEDSEGAWGAAPGDHLPTDQWGGYSCTWGEFGFGDGENNGWSGWDVSAIQAQISNQPVHGMSICQANGKGCSIITPDAKKVVDAYVQSKKHLDGIGGAASPGPVRLKVLLDYRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q9D3</accession>
    <name>W6Q9D3_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S02g000949</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM30799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6Q9D3"/>
    <dbReference type="OMA" id="DTHLIVC"/>
    <dbReference type="OrthoDB" id="5391496at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM30799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="219" mass="23995" checksum="845DEAE7ECE65CD0" modified="2014-04-16" version="1">MGPTCTVAHCELVSDLLQQLLEGNSDTYLIVCATKAEFLVQLTAAIRSQCADPDMAASHGLLTKTIGLLARSSKIRLLFCPSLESLRAYLAIFDTAVGVATEDRSLAHDRQLIAVLDMIALHVTTSEFSAQGLSRTLASLVEASSRAGMDLQVYECVNALDPSSAVRGKMLWDVSVPLLNGSVRMRSDQSIWSGRGVTVKRVAERWFEFDQNWERMENA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W6Q9G3</accession>
    <name>W6Q9G3_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PROQFM164_S02g003410</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM33258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1365484.W6Q9G3"/>
    <dbReference type="OMA" id="LPHNARG"/>
    <dbReference type="OrthoDB" id="2250022at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000983">
        <property type="entry name" value="MFS transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF6">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G16690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="71"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="105"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="241"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="268"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="300"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="332"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="1"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM33258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="396" mass="43540" checksum="BF146F99135E091F" modified="2014-04-16" version="1">MFINRISRPSLYISVAMILWGVISTLSGSTKTFGDMVAVRFLLGFVEAAFLPGALLILSKWYTRRELTTRNAILFCGNLISNAFSALVGAGVLSNMQGVMGHAAWRWLFWIEGSVTMFLAILAAFILPDLPHNARGFTEEERQVAQLRMLEDVGEADTDGEELGALGGLKMALVDPKIYVMMFTFVAYVVGLSFNAFFPTLTGTLGFGYVPTLLMSAPPWVFSCIFSVINAWHADKTQEKVWHIIGPIGMGAVGFIICMATSNTAARYVALFLQAGSYAGFIVFYSWISSSFPRPPAKRAVAIAMINAFSQLGNVAGSYVWDLEDNGYRSSYGIVLAMFGVTVGGCWYFRSMLVSLNHQLEEGELADGARGDSTENDIIDHPDESLRMRKGFRYLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W6QA00</accession>
    <name>W6QA00_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S02g001154</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QA00"/>
    <dbReference type="STRING" id="1365484.W6QA00"/>
    <dbReference type="OMA" id="PPEWRRV"/>
    <dbReference type="OrthoDB" id="5412996at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM31004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="87" mass="10364" checksum="2D7BA2ABB90946F7" modified="2014-04-16" version="1">MFPEEKVRNEVAIMRYILDQTSIPVPFVLHWGTRKDGPLDPELGPFIIMEYMDHHTNMYDVLNTPGRSRAYRRILDPDFDEDELERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>W6QB37</accession>
    <name>W6QB37_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Zn(2)-C6 fungal-type DNA-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PROQFM164_S03g000404</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QB37"/>
    <dbReference type="STRING" id="1365484.W6QB37"/>
    <dbReference type="OMA" id="QKGVGFH"/>
    <dbReference type="OrthoDB" id="4060227at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF17">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="510"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="32"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDM33680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="640" mass="71659" checksum="B9493250806BFA95" modified="2014-04-16" version="1">MDIELPSPPPVSALRESFGDRKPPDITRKITACVACRKQKVKCHMGEGQMPCSRCKKRGLPCSVNRSLQTLLEDDVTWKGAVVQKMRRLEEAVAKIAAKVDMPEFQALQTVQAAPEIQDNSLSPPVETINEKVIAGEISTSSQPSQPNEHHEPPQTWEVIMDPRGGPASIPASCVSESGKAGLPNNPSTSRRPDLISTGLILLRDAVSLFETYHLRLDHFLYRILGDHISLDSVRIASPLLTAAVCTVAALHSHSLGHLFETCYGEYKNVVAAQTFSRHMNEDDIRGLCVGAFWLHELSWALIGNAVRIASDINLHSGIYKALKGDRDGYLQARLYYLVYVCDHHFSIAYGRPPMSREGFIIESASRILETEHATEDDARLISQVKEWSILGRVFDTFGVDVDTPIAPQTLPQLRRCSISLDTWFADWSESFKANQNVGNYPQKGVGFHYHFAKLYLCSHAFRGVPISESSPQYMSPELEEIANSGVLSAMSILRMIVSDAEFRSFMNGLPLYFDTMLAFAVVFLLKVATKYAFMVRIDTTKILSLVTDTVAALRDITQSMHKHHLLVVISEGLERLSSRCQMSAHTAHETMYRTSPAQEQPPVFDAIWMENMASFDFQTIFPDIDDWWLHYNTSMEPPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W6QBA6</accession>
    <name>W6QBA6_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S02g001579</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QBA6"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM31429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="59" mass="6796" checksum="A777BA53A69C65D9" modified="2014-04-16" version="1">MENTTDIHPACDCVAHRKDYQHWPKENAEIRIASCMRVCPFCAKKHSNASRLRKHLCSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W6QBQ0</accession>
    <name>W6QBQ0_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Acyl-CoA N-acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PROQFM164_S03g000604</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QBQ0"/>
    <dbReference type="STRING" id="1365484.W6QBQ0"/>
    <dbReference type="OMA" id="MICHTFD"/>
    <dbReference type="OrthoDB" id="47059at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009254">
        <property type="term" value="P:peptidoglycan turnover"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050226">
        <property type="entry name" value="NagZ_Beta-hexosaminidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30480">
        <property type="entry name" value="BETA-HEXOSAMINIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30480:SF16">
        <property type="entry name" value="GLYCOSIDE HYDROLASE FAMILY 3 DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="6">
        <location>
            <begin position="538"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="6">
        <location>
            <begin position="708"/>
            <end position="852"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM33880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="852" mass="93714" checksum="3F0FDC33F16466DB" modified="2014-04-16" version="1">MVSSDLKKQVGQLFAVGFYGCTPSPEIKILIHDYHVGGIVLFSRNFENSEQLQALTLALQNEARLAGHERPLLIGIDQENGLVTRISPPIAAQVPGAMALGATHDPECAYSAGKATGETLSFFGINMNYAPVCDINSEPLNPVVGVRSFGDDPEFVGRFASAAARGLREQNIVPSVKHFPGHGDTAVDSHYGLPVIPKTRDQLERCELIPFRRAVAEGIETVMTAHISLPCIDLTRPATLSPDVMGILRKDMAYDGMIITDCLEMDGIRSTYGTEEGSVLALRAGSDSIMICHTFDVQVASIKAVCEAIKSGRIEQSRLADACRHVATVKDKYLNWDVALQKSNLADLNSLNNRIAETTMDIYSRSTTLVRDKNGILPLSKTSIIIFLFPGDNIPVGGAVDGEGTGRPGLYQSNRYLDVLRQHNNSIAELRYGATGLTSEQWRTLEVADVVIFTSFNARESPYQESLGLELAERVHALVHIAVCNPYDFLDAPSVKTYITTYEPTIEAFSVAADIMFGALVPTGALPLGINASTKTSAVVMPFDAQRDLDEVVEVWAAALPTYLIPAESLRSLIVRPHGHHFIARFGSQLVGFCLAYTNAHSAPNTVYIAVLAVSPKYQHQGIGIALLDETRAYFRATFGFNNVKLGSSFPRFWPGIPQDLPETVQHFFTHRGFRLSPPSARSVDLYQDIRNFQSPEKYITRARERGFRFAPLKPEDYEACLVGQRKNFSKDSSWVEAYVALHPDKYPDSVMIAFDSHGQQVGWTLMLGPSYALNKSWAFPQICGPNTGLIGAVGIDESHRKHGIGLALICHAIENMKQRGIEGVFVDWVALDGWYEQVGFKTWRSYRPGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2024-10-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>W6QBS3</accession>
    <name>W6QBS3_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S03</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S03g000882</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QBS3"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM34158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="39" mass="4159" checksum="B7323EF36C3BFB9F" modified="2014-04-16" version="1">MPRSLLPINFGISAIWNAVTAVLIQSEGPAMKLASSMRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W6QC58</accession>
    <name>W6QC58_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Cytochrome c oxidase assembly protein COX20, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PROQFM164_S03g000774</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in the assembly of the cytochrome c oxidase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the COX20 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QC58"/>
    <dbReference type="STRING" id="1365484.W6QC58"/>
    <dbReference type="OMA" id="NWAVGMF"/>
    <dbReference type="OrthoDB" id="14603at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022533">
        <property type="entry name" value="Cox20"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31586:SF1">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX20, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31586">
        <property type="entry name" value="CYTOCHROME C OXIDASE PROTEIN 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12597">
        <property type="entry name" value="Cox20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007871">
        <property type="entry name" value="Cox20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="8"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR007871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CDM34050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="204" mass="22691" checksum="D61931AA24771D02" modified="2014-04-16" version="1">MAEDSRDSSTLSKAGSNTQIPNDLADSQKPKYNPSQSQTGKLWDAFGNPEEPANALARATYKPRGKDPKDVPYSEIIGSFPVSEMTTLHKRPCARESLLTGIGVGFGVGGLRGVLKGRYYLWSAGNWAVGMFAISSLASYEYCRWRRNNELSGMAEALDLMNQLKAKKQREKDTAVEEAALRARLAEEEKKSKSWTNPSNYKFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W6QDA3</accession>
    <name>W6QDA3_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Helix-loop-helix DNA-binding</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S02g002320</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QDA3"/>
    <dbReference type="STRING" id="1365484.W6QDA3"/>
    <dbReference type="OMA" id="RVKTWDI"/>
    <dbReference type="OrthoDB" id="2133190at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032933">
        <property type="term" value="P:SREBP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11399">
        <property type="entry name" value="bHLHzip_scHMS1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052099">
        <property type="entry name" value="Regulatory_TF_Diverse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019006">
        <property type="entry name" value="Sre1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47336">
        <property type="entry name" value="TRANSCRIPTION FACTOR HMS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47336:SF2">
        <property type="entry name" value="TRANSCRIPTION FACTOR HMS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09427">
        <property type="entry name" value="DUF2014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="427"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="BHLH" evidence="3">
        <location>
            <begin position="164"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="339"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="875"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="962"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="264"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="966"/>
            <end position="975"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM32169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="1035" mass="113842" checksum="C5763AB2BC44B586" modified="2014-04-16" version="1">MSGPNMENDFQLFSSRNPGGDETRGNGHLFTHPVGENVNQDWTQWMRWDEPMFSEGDQKPMASSIDLPSISPQTDMSSPSHLNYGDFSPNLPLGLMEIPSEPNAGNNVGYTHRLPGPNRTSQQQPYGLVSPISSVGTSRKRKTGSDDDATTVTGPVQPGKKMPAKKRAHNVIEKRYRANLNDKIAELRDSVPSLRSPKNPNGGSADDDDEAEGANAANKLNKASILSKATEYIKHLEIRNQRLEDENTDLKNRLRQADKVADQAATSSGSVSSPSNYASTDSNSGTSPSVFSQAEDVSSESSPTSPNPPEGLLPVPDAWKRMRAETAKQGVFAESYIKYPSSSSSSHQPQYAREDTSTRRSRMPNKYMLGALAGLMVLEGMGSDDSESESKGLFSLPISLLGRFQTPTLAHCEFYLKQFWYSWQARAFSHFLILATLVVGSAFIVFVYLFNAQPITRRGPSKLATEGPAAPLTSSDFRRQAWLTSMQRVGVPRHRFFREWYVVTSRCFEYVLRCFMGWKVYSWATGITEEDEKGRVKTWDIAIDAQLTGGDAEISKSRLVLTIFAAGTLPCTPARMIIKALHVRILLWNVGEAGSWSFHVSNDIARALARFQWGVAREINSALPEGHPDQLPPHLAALIKLDCEDVMIDNIIQRAVNLTWNRPTQEGTGDDEVLLDVVDEDPAIQCSQDALAAWWSSHLLQTALLNYFEASGKGPVSKASRDAFKEKIRMSLDVAPVLSAAHTRALVMKAVFFEHNRIENVGAVLAALPKEKRKGSHSHSSNFLDSSLPVSVRDEISIAVRCAMIATIVTERSTGGVSSLPDSFTMEKAVSWFNQLPIDPVELSLIGFSSVYHLLHLLASDVDYIASSDSSPSAPASEAAISSADDEAEEKPRPNQKLSLCPRDIPNLGRVSAELIYWARNAYTPAFYGFSSTLVEVIVNSCTAICQNAGINVEDFVHTAPDRAMSKKRRTRRRKGESQSSESDADQDLIDYPVERPPLRRARSASNDTGYGSLSVEEDGRPIPHAPSNVQEVPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W6QDC8</accession>
    <name>W6QDC8_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA mismatch repair protein PMS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PROQFM164_S03g001204</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutL/HexB family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QDC8"/>
    <dbReference type="STRING" id="1365484.W6QDC8"/>
    <dbReference type="OMA" id="MRPRRMP"/>
    <dbReference type="OrthoDB" id="10263226at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032389">
        <property type="term" value="C:MutLalpha complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000710">
        <property type="term" value="P:meiotic mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd16926">
        <property type="entry name" value="HATPase_MutL-MLH-PMS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03484">
        <property type="entry name" value="MutL_Trans_hPMS_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000074">
        <property type="entry name" value="DNA mismatch repair protein (Pms1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.100:FF:000001">
        <property type="entry name" value="Mismatch repair endonuclease pms1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000014">
        <property type="entry name" value="Mismatch repair endonuclease pms1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.20">
        <property type="entry name" value="MutL, C-terminal domain, dimerisation subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.100">
        <property type="entry name" value="MutL, C-terminal domain, regulatory subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013507">
        <property type="entry name" value="DNA_mismatch_S5_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002099">
        <property type="entry name" value="MutL/Mlh/PMS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038973">
        <property type="entry name" value="MutL/Mlh/Pms-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014790">
        <property type="entry name" value="MutL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042120">
        <property type="entry name" value="MutL_C_dimsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042121">
        <property type="entry name" value="MutL_C_regsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037198">
        <property type="entry name" value="MutL_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00585">
        <property type="entry name" value="mutl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073:SF52">
        <property type="entry name" value="MISMATCH REPAIR ENDONUCLEASE PMS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01119">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13589">
        <property type="entry name" value="HATPase_c_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08676">
        <property type="entry name" value="MutL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01340">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00853">
        <property type="entry name" value="MutL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118116">
        <property type="entry name" value="DNA mismatch repair protein MutL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair protein S5" evidence="6">
        <location>
            <begin position="219"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="MutL C-terminal dimerisation" evidence="5">
        <location>
            <begin position="783"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="364"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="388"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="364"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="397"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="407"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="469"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="522"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="537"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="597"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="648"/>
            <end position="657"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00070941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM34480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="1007" mass="111266" checksum="556AAA29E53CD98C" modified="2014-04-16" version="1">MNMATIQAIEARSVHQIQSGQVIVDLCSVAKELVENSLDAGATTIEVRFKNNGLDLIEVQDNGSGISPENYENVALKHYTSKLSSYDDLSSLHTFGFRGEAISSLCALAEFHIVTAQEKQVPRANRLDFEQSGKLRKTQIVAGQKGTTASVEGIFKRLPVRRRELEKNIKREYGKVLNLLHAYACISTGVRFSVRNTVGKTRNVVVFSTNGNKTTKENIANVYGAKTLSALISLDLELEFEPSTATKRIGDDQLSKIQVRGHISRPVFGEGRQTPDRQMFFVNSRPCGLPQIQKAFNEVYKSFNVSQSAFIFADFQMDTNAYDVNVSPDKRQILLHDAGAMIESLKVSLTQLFGDAEQTVPQSSVKSKPLSKQQPLASLPGFVTARELSENGGIRSPSRDRTKESSVETSGASQQSAIQRFSSSEAGTGRTQVTPSPARSMRTPRAATDRSSMSTPAPSELETPAAAISDDELFVPEAAQEEPEPALISDEPSSQPSAPDETPSRARGDPEEIPSIVQNAFDRMRPRREPAELATITIGNRTVTSMVGSGLPRKRVAEDPPLIRAQPRRKRLIHTPSRPNIFSDHMKSFAAPGSQPVDEEDEEASASEDDQIEEDGSNPSSEIEDTQGAEEESEEEGSPPPENADYIPNQSAAQSEPENTEAKDKETAVDDNIGEAQKKAQEEATVQRLIHEAEETAVLPEENSANRAKKMSKGAAHRDATIQLIGTVDGSIARLQSQLITLQKTMRDGTKKPREEVTDLGEKTAEDKLSLIVSKNDFAQMRIIGQFNLGFIIAVRPGEDQDELFIIDQHASDEKINFERLQAETVVQNQRLVRPQRLDLTAVEEEVVLENRAALEKNGFLVTVDESGDEPIGRRCQLVSLPLSKEVVFGVRDLEELIVLLSESISTPNGSSVPRPSKVRKMFAMRACRSSIMIGKTLTSRQMERVVRNMGTIDKPWNCPHGRPTMRHLMSLGQWDEWNEYQDTEGLDPWKQYLEGEAEEDEEEDGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>W6QDS4</accession>
    <name>W6QDS4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type DNA-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PROQFM164_S03g000955</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QDS4"/>
    <dbReference type="OMA" id="HLSACKH"/>
    <dbReference type="OrthoDB" id="2399539at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47431:SF4">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47431">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="20"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CDM34231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="574" mass="64043" checksum="914A5BA73B0EFA54" modified="2014-04-16" version="1">MSDTPERNKPSKRGTRNSLSCAQCRYKHLRCDGRKPVCSRCATNTVQCVYPLSRRRGNPKSAKPRSPVRDVYDNTVETSLQTSTVCSSSSTAINGEIESTSNSAASFLSLYYEFFHAAHPCALPFQVLKTRLNEANIQPLLRVMSYIGSIFDISCPSQLLESCAQRAQDSVVEIRSSIRPLTPFDVQALLLYSIAVYWCNETESGVELLDEAIRMAVALGMNKSEFARNHAEADSVLEESWRRTWWVIYITDAHIAGSTHTYPFRTSGIEITTDLPCEEEQYEIGVIPTPRSLDDYENREFLDEEKSDFSSYAELIGLTRGIDRALSPGNSAYDQIYTTMAASCDTSVRAWCSLLSPEKRELIHPDGSFDEVMFKAFFIMHTYTVEIHRPLSALTHSAIESVSRCAPLAPSAHLKCSNAKERDLHTVKCTQAINSIDELLTLPTNMTTHSPFIICMIANVTIAHLSACRFIFSGDRRAKSREKIRLTMGTLKRLSEHWTLGKRTYREIGIIARELLSLTTDPSIGLDAVDLSLPGPTSPAFPPLDTLPDANFDICAFFDTDALGLTETSSFILQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W6QEL4</accession>
    <name>W6QEL4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S02g002795</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QEL4"/>
    <dbReference type="STRING" id="1365484.W6QEL4"/>
    <dbReference type="OrthoDB" id="10417244at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM32644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="229" mass="25935" checksum="600BFE7714912D64" modified="2014-04-16" version="1">MQRSPAENLLTQRSPAGLTCHHSVPLRSSLGNAAPPCEDCCSRRPILRSTFLHSRGSWQRGSASLTSLGLWQRQPWSRRLSSPQAREGYYDIPECEDRSPEFFWAGNRAPFIFFGYVSTKEPVAQLVVRVTVSLISVEVISTTLKGCLETLWPIDSSLDLAYFLLKLCVEYGEPLSSTVEKKATPQTYGSYISSNLQLNRLTRLHSTCPHFNHGYHFLMRVEVLRQMPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W6QFA6</accession>
    <name>W6QFA6_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S02g002955</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QFA6"/>
    <dbReference type="OrthoDB" id="6359816at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM32804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="65" mass="7473" checksum="5B960C42C1496D00" modified="2014-04-16" version="1">MFQPFKVYNFIDTYLVTELKDLAFKKFTAVVINLGKPKNLDKQLAVIDCLSLAFPKSSLHDKLPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W6QG61</accession>
    <name>W6QG61_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha/beta hydrolase fold-3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S01g002448</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QG61"/>
    <dbReference type="STRING" id="1365484.W6QG61"/>
    <dbReference type="OMA" id="SPWCSLT"/>
    <dbReference type="OrthoDB" id="2152029at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF31">
        <property type="entry name" value="STERYL ACETYL HYDROLASE MUG81-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="3">
        <location>
            <begin position="115"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM28637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="356" mass="40132" checksum="590FE02D642B4DE0" modified="2014-04-16" version="1">MSSNEDGPGPQLGFWEKADIPFMYLSLCGSLVYAAIAGVFRGKASPRRYDHYVVSAVVRKLLTRRSDRQMQYLSPSTSAAYEGVMKKHGLKPETVVLPHNTEGHWIGNKDAKNVIIYYHGGGFAVPAMAAYFEFWLDMLKDLDKTGDNLAVFFPRYSLTPESTYPTQMRQAVEALRYIINETGRSPSNVIIGGDSAGGNLAAATLLHLSHPHAEIKPLELSVPLAGVFAFSPWIHFSTDWPSIEENKWKDILPREALERWTISYRAGLPEDNWNQPFDAPPGWWESAKTERILILVGEDELLLSPIREFAKKVKAEFKDITFVIGQDESHDAPFFTMMKEETPTHSALREWLASRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W6QGM4</accession>
    <name>W6QGM4_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S04</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S04g000007</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QGM4"/>
    <dbReference type="STRING" id="1365484.W6QGM4"/>
    <dbReference type="OrthoDB" id="4365473at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM35126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="240" mass="26966" checksum="75925E398C5CCFEF" modified="2014-04-16" version="1">MDTKDSQEFLLWAAGFLKPWFASDLAWSNDLIGKLGSNALPLALAHVGATVRNGFSTPEDYLALLEEQQTRETQADPSQDLQRLAFEVAIAQIRKQKDQPSKDAHKLLNAFVFFPNRHMSLETATKAIITSRTIGGEQRRRYHKRYPTSKLIRRNGKAYNTSQSTSRRQSSDSVALSRVHWAIMELLDISAVIYHPSSGTYSMEAVLKSWIADSLGQSEREVWKNLAGMIAPQKASKESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W6QH75</accession>
    <name>W6QH75_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Genomic scaffold, ProqFM164S01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S01g002788</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792015">
        <property type="protein sequence ID" value="CDM28977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QH75"/>
    <dbReference type="STRING" id="1365484.W6QH75"/>
    <dbReference type="OMA" id="NGDDCSW"/>
    <dbReference type="OrthoDB" id="3692311at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="158"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="565"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM28977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="665" mass="72576" checksum="FE93FA14D78E2572" modified="2014-04-16" version="1">MRQSKSAPYGALPGEENYSRTSEFQSYTAIELPEIDDQKYRPQPQPLKVSQLDRISRLLWDLTLAIVALLFTVFGIWVSCIDGKPAGPDSMGSKLFEVSQYAPTVFPVLFAAIAGSSIKSIASWRIQTTGGATIGLVEQCLGSQNITGAILTQIRLRAVNFVAVFTILLWCLSPLGSQASLRVISIVPSYPGNPVELTTLSTFTPYQYGYHQMATEAITSVANPMTASLAAGRILATRNQDLWGNIRPPVIENLETNSTGWMNAPQNDNLTYASLVGMPVIGLPGSGNTSFTLSGSYLSVSCPVFDTIHTLNFTNFTGSSAPSPGNGDDCSWTSAWGGYQFMIAISEPCSYSLNASMTRTRNARKLVWESWDRGYAGAIDDRSPITRAICDITTTYVDSNVTCESSGGIQSTNTCNLSSVRRSVDESHFHKNWTVFDLNLPGDPELPKSYNYGLLDILTTLYPYVEQNGGLQPLIGYFIDPYNPVVDFFGENLMSPKTTTPKVFGTRLSQIFNSMLYLGVSPSAFTGSVNMTKITQKGSQIKNTPVKFMAKNTHLQNIVKCDRPWLAVLIVSSVVIFCFALVGAYLHLITIAPDLLGSISVVLLQNKIEGIVGSSTWSSDEWSKNTRDTKLWLGDVQPETDVGCLALTTVAQDVPAGSVKQRLYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W6QHA2</accession>
    <name>W6QHA2_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sterile alpha motif, type 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S03g000303</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QHA2"/>
    <dbReference type="OMA" id="PPDMNYR"/>
    <dbReference type="OrthoDB" id="422827at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09535">
        <property type="entry name" value="SAM_BOI-like_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07647">
        <property type="entry name" value="SAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAM" evidence="3">
        <location>
            <begin position="263"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="735"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="333"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="337"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="368"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM33579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="893" mass="100653" checksum="09CD5D7A4100AD50" modified="2014-04-16" version="1">MNMNSSLAARRRVVPAEVDTTNHEWFYPKKTVEKQRPNSGATFFDDTDSESGDWRQSHRQSMQSYSNGSNTTLSSPELPTPDLLPRNLPTFRSSKELIAGPSGPDLFRGSRGSTVDVEFYLEPSPSLDFKSLTQPEFVNPHQAEFVNQYQAEFVKYQDERPNQYQPERSNQYQPEFVNQYQDERPNQYQPERPNQYQPERSNQYQPEFVNQYQDERPNQYQPERSNKYQAGRSNPYLLSPKTPKAFPRNPDVSHLSKKEIRNWDPSQVAHWLFIGGYPDDIRDTFLKNDITGDILMTLTKDELEYQLRIQSMGRRVQLIQSIDYLLENMQTRPIPETPSQFPSEAASSNGRRSPESFAPQELAPKRTPTGQSYTMSISPDGKILSSHAFGQSGDQSTADAESVSIVGIEEFHPKPHRCSKGEKCSKFKKLKEKRLKKLTTEYPGADFQGGAIFVGSPGNPETARNLLRPTSEAELSAMASSNIFGPRSGPRLSEAALSEVQRLDPQETIRNFLRHQHIDDFPKPGPLGLDTYNLPPADDFEDISPLNAQSNSMAANLRSLPRLTIPTSPLTEDMTTAVTTNRYFTPTHQNGSPTAVQQFGPFSQVHQAQATETYRQGTPFSEVDVPITAIPSDPISRDVSQSVPPSMQYGTLFPPYRDANHLSRSNSTRPSDDLPLRDANYFARSTSTRPRDAFPLRQVNEGKPLTPIDVPADLIRSPRVNQYGNSSSLALADPEVTHAGYMKKRKTTRLLRHEWSDAHFTLRGTNLAMHKDERDAHRISRALENIEVDEYAVACSSLATSSKLTAAFKRSILRNGNSTTDIRDGTAFAFSLIPATKESEKKALFGNSAVKTHHFAVKSREERIDWMRELMLARALKKGRDGEDGTSMDGNMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W6QI51</accession>
    <name>W6QI51_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATPase, F0 complex, subunit H</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S03g000588</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QI51"/>
    <dbReference type="STRING" id="1365484.W6QI51"/>
    <dbReference type="OMA" id="GHVQKFT"/>
    <dbReference type="OrthoDB" id="274752at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019711">
        <property type="entry name" value="ATP_synth_F0_suH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28207">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT H, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28207:SF1">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT H, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10775">
        <property type="entry name" value="ATP_sub_h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="96"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM33864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="122" mass="13333" checksum="086DEF24F736A094" modified="2014-04-16" version="1">MMSQSLRASRTLFSRASRAQVSVARRTFLTSAVRQADPVQDLYLRELKAYKPTPIKAGDADEHVQKFSAPAPPKSPEEANLASELSAYESQEVEVEGQAAAGEAAPVEESWFEEEEEAPAAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2024-10-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>W6QIM2</accession>
    <name>W6QIM2_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S03</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S03g000783</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QIM2"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM34059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="49" mass="5645" checksum="D67C68CD1EE7A603" modified="2014-04-16" version="1">MFHKLSVSLSFVTPATKWMLPDFERSVEYGRDGGLWHGQHSERTCSDCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W6QJ97</accession>
    <name>W6QJ97_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S05g000328</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
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            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
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        </source>
    </reference>
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    </dbReference>
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        <source>
            <dbReference type="EMBL" id="CDM36495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="152" mass="17481" checksum="A47CAE8118E189B2" modified="2014-04-16" version="1">MANLSDIRKEILEIDIAKRIVIKVKTESLDPQDYRASANTVVSEVFPDWESDPRILLLAIDVWSERTFIVIDINHHDYDFGTAHKAKTILPVFVLRQHGKRPDWVLIRWPQGDEPLAAQLADLHNVNGFDATPFLENHNSRIVHANPREFPV</sequence>
</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR28271">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28271:SF1">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09784">
        <property type="entry name" value="L31"/>
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    </dbReference>
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    </dbReference>
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        <source>
            <dbReference type="PIRNR" id="PIRNR002216"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CDM34379.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="107" mass="12652" checksum="0D984882CF2BA229" modified="2014-04-16" version="1">MFKSTQALFGGLLWKTPWRLSSPQKARQRKRLRSVDRVVDTVSAALERNGQTSKAVTRWFAEMPREEEMLPKDKYTLFDKKEKSYRKSIHKLPKWTRVSQRVNPPGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
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        <lineage>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
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                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
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                <person name="Abraham A.L."/>
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            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
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        </source>
    </reference>
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            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004879655" evidence="1">
        <location>
            <begin position="22"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM34429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="94" mass="10389" checksum="50E89AC0A66D8CB6" modified="2014-04-16" version="1">MLSFLFFLAFHVILLTAWVSGYLDPYQKQLQELLLDYMGESKVSYGLKRSLTGKKLTEDQNLSKIQDQLGNQLGDMFGKGGLGEGLGSVLSKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W6QJP9</accession>
    <name>W6QJP9_PENRF</name>
    <protein>
        <submittedName>
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        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="2 3">
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
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                <person name="Abraham A.L."/>
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                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
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                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
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            <end position="129"/>
        </location>
    </feature>
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        <location>
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            <end position="240"/>
        </location>
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            <end position="407"/>
        </location>
    </feature>
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            <begin position="435"/>
            <end position="536"/>
        </location>
    </feature>
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            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
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            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <begin position="96"/>
            <end position="129"/>
        </location>
    </feature>
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        </location>
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        </location>
    </feature>
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        </location>
    </feature>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="480"/>
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        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CDM34439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="536" mass="57392" checksum="A72EB8F9D351095F" modified="2014-04-16" version="1">MNDGRNAVSNRGVLHAEASANTYSVNNATPPVPHKPTTPAKTRTTQSPKPKPLSLQIDGLNVVIPAPGEGNSNPAYIESSERGSDTSGDGRRLDLSASTVTDSLSSFPSSANGNSQSTEFGNSHTLNGHTSIPWVDPELLESQLAPHIQPVNGGASVDRWQPSLSPIKAGNVSISPPPSPKHSRTRSNFDARLAPGQKRTAAGDFKSTLDPPTAHSADANGAARQRSKSTGSSAHGSRIAQLSVHIRTRLSYAAAKVEQARQSREATPQTALRTRNMPLSPSDKASLPAGNSTHFLQDSQTSSNGNSRYFPSHNRSRSACSSNQFLPIPKLAPPVDIIASNGHNQRRRPNPNAISNPSNRSPISHHRRHHSHQENGLTPPLNGQAVLGPGTPSLSSSHTHAPPTPNAFYRLRTQSQNTLMEQDAIETLMFMSSPENSGYRFSPRPLQPTSTQSSQNESVHASSNGAHPDGSQGSQSSESHNGRGLERKPGLEAHAGDDIDRLLDQMDSDSDDEDRYASYRSGINGAHPFRGHQRPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W6QKS5</accession>
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        </submittedName>
    </protein>
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    <organism evidence="3 4">
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
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                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QKS5"/>
    <dbReference type="STRING" id="1365484.W6QKS5"/>
    <dbReference type="OMA" id="SFKRHTL"/>
    <dbReference type="OrthoDB" id="4309132at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="721"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="147"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM36611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="830" mass="91777" checksum="064C9A0B580F45D0" modified="2014-04-16" version="1">MEPTMDVTMNPNDSPLSNLDVWCDWSGIPEEPVSITISMELQTCGRPNLNLPILNVQSPNTTKSPSWVIELKPEAQSHYETDTPPEKEAWRFGQEYADETERYPTDNISASDFGSVVVHDGSRDDDSRRISRRTDNISGMHTRVDSSDSSTLSDLSKSQVNSLGSPSSAIPRKRSAKAASLPDSIPPDDEYQGTRRKLMMNNIDLPSTIENTANSTRTHRRSATPDESSVVLENMPLPQDSGPSHGPGSPNVASEHLSRNGNAAAVGNVPEPDENSPWCNAETPLSTTDLSGTEPLTEENLLQRNYDTLSTCVCHGSISDTEESDKEIETLFFPLESIGSASFFSCHGLPLPQTAAEIAEKHKPKIVLDNDILYLQTPPNIYPATYQIAISLTVRLQKGKPWDWWELVVSGLPRLAQSESGYLYFRTPPGQGMEFMTSSFKRHTLVESCLMAQFYGGRNLVIPFRKCDAECFGQLKDHKVNTLIRAEVAEAGDPSSYLIKYNAACSIDLINHNFWAEQCKFCIFVHGGPDGEFDAVFTSKKPLINSIQLPAADGTGISRINIVSIPQALDMFTVSWEIKLPRGKAVTWLPWIKTTLSCSDAETVLQEDYAIYAPGYELTKQEAVPSKYQNADTRCEVSCGQLGDICVPGLNHSKLDVEITPPYLQDGSIPKFGLTEPLFGKIPASRSTSTQTVAETPAPVSTVFETLVAERTKSRRVRGLWTLWTLINFFFQLLVFLASVHIISSSYFLLSHVSREAHVYGPVNYAGNLTTNADVVQETETVLAESNLQLEPIQPEVQQHVNTTPAEVTPISLRDRIDYILGWRGPIARE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W6QKX8</accession>
    <name>W6QKX8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S05g000489</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QKX8"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM36656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="51" mass="5912" checksum="85FA6732643695E4" modified="2014-04-16" version="1">MPGRSHRRHWVELMLPCPQQQDRTSQSGAVGSISHQSYLEYLFDACSQRHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W6QLC5</accession>
    <name>W6QLC5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PROQFM164_S06g000610</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0357 family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792020">
        <property type="protein sequence ID" value="CDM37648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QLC5"/>
    <dbReference type="OMA" id="NIRDGDS"/>
    <dbReference type="OrthoDB" id="447314at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018559">
        <property type="entry name" value="DUF2015"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28023">
        <property type="entry name" value="UPF0357 PROTEIN YCL012C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28023:SF1">
        <property type="entry name" value="UPF0357 PROTEIN YCL012C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09435">
        <property type="entry name" value="DUF2015"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CDM37648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="124" mass="14236" checksum="D6D4ADA1950AC12B" modified="2014-04-16" version="1">MTYILFYFLLFSVIISGTALYLTRSRWMPLIQVPDYLYHRLPSSFTADLEAGLSSSQFDITANLADGDSRAGLDQRAKKEVIKIMKSQKVDFDEARRIYTEQRFAKNNIGPDGRPRDPKFVSFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2024-10-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>W6QLP0</accession>
    <name>W6QLP0_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S06g000311</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792020">
        <property type="protein sequence ID" value="CDM37350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QLP0"/>
    <dbReference type="STRING" id="1365484.W6QLP0"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM37350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="184" mass="20687" checksum="BFA0D6948CF9F978" modified="2014-04-16" version="1">MDMNQFPDVAPDQRDLIQYFTCQASVMISCHPQMQHEACNVLMPLSSASNALLYSLLAFAAGHQASRTTDEVEKRHFRRQMIQLETKSVRDLQGEISLQLRSGLPLMASSLILCLCSLCHEGDDYISWRAHLRGVKAAFSIISATEFAGKESQIEYLTKRYQLLEAIAMLTAKGFEALEPKDDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W6QN04</accession>
    <name>W6QN04_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S10g000067</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792024">
        <property type="protein sequence ID" value="CDM38253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QN04"/>
    <dbReference type="OrthoDB" id="4324196at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM38253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="53" mass="5900" checksum="BDF64B206B679F35" modified="2014-04-16" version="1">MQRRRVKYVTPAQINTRKLSQQSQVGEPKAQHSSPDGINKDIDASDYVLVSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W6QNG0</accession>
    <name>W6QNG0_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">methylmalonate-semialdehyde dehydrogenase (CoA acylating)</fullName>
            <ecNumber evidence="2">1.2.1.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">Aldh6a1</name>
        <name evidence="6" type="ORF">PROQFM164_S07g000269</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.27" evidence="2"/>
    <dbReference type="EMBL" id="HG792021">
        <property type="protein sequence ID" value="CDM37920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QNG0"/>
    <dbReference type="STRING" id="1365484.W6QNG0"/>
    <dbReference type="OMA" id="GGAKNHI"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004491">
        <property type="term" value="F:methylmalonate-semialdehyde dehydrogenase (acylating, NAD) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006574">
        <property type="term" value="P:L-valine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006210">
        <property type="term" value="P:thymine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07085">
        <property type="entry name" value="ALDH_F6_MMSDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000002">
        <property type="entry name" value="Methylmalonate-semialdehyde dehydrogenase (Acylating)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000003">
        <property type="entry name" value="Methylmalonate-semialdehyde dehydrogenase [acylating]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010061">
        <property type="entry name" value="MeMal-semiAld_DH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01722">
        <property type="entry name" value="MMSDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43866">
        <property type="entry name" value="MALONATE-SEMIALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43866:SF3">
        <property type="entry name" value="METHYLMALONATE-SEMIALDEHYDE DEHYDROGENASE [ACYLATING], MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="5">
        <location>
            <begin position="101"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDM37920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="588" mass="62617" checksum="0A1469305526107E" modified="2014-04-16" version="1">MAACRSIARSIPTVRAVPRTVSVTARAASSRSLTTSSLASLVSRRVAVPSSSLSATRRLHATAQRLVQATTSAVSTATEYPTSHEKIANPIDTANFIDNEFVSSKASKWIDLHDPATNNLVTRVPQSTDAELKAAVESAEKAFPAWRATSIMARQQIIFKFTNLIRTHWDRLAASITLEQGKTFADARGDVLRGLQVAETACGITTQMTGEVLEVAKDMETRSYREPLGVVAAICPFNFPAMIPLWCIPVATVTGNCLVMKPSERDPGAAMILAELAKEAGFPPGVINIIHGAAPTVDFILDEPAIKAISFVGSNRAGEYIYARGSANGKRVQANLGAKNHAAVLPDANKNQALNAIVGAAFGAAGQRCMALSTCVMVAETKEWLPEIAERAKALIVDGGFEEGADLGPVISPESKKRIEDLIASAEEEGATILLDGRGFKPKNYPNGNFVGPTIITNVTPDMKCYKEEIFGPVLVCLNAETLDDAIDVINANEYGNGAAIFTRSGSTASKFQKECEAGQLGINVPIPVPLPMFSFTGNKKSIAGGGANTFYGKPGLQFYTQQKTVTSLWKSEDAISTKANVVMPTHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W6QNS7</accession>
    <name>W6QNS7_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BTB/POZ fold</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S21g000006</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792035">
        <property type="protein sequence ID" value="CDM38588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QNS7"/>
    <dbReference type="STRING" id="1365484.W6QNS7"/>
    <dbReference type="OMA" id="DMENLSA"/>
    <dbReference type="OrthoDB" id="6359816at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843:SF5">
        <property type="entry name" value="BTB_POZ DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="24"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM38588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="324" mass="36611" checksum="45148CE3F9F72C25" modified="2014-04-16" version="1">MQQRQYQDVVLGIIASLHLNPDYSDLKIFCQGRVFPAHKLVLCPRSKYFQSACCGSFEESRGSVTLDTRSPTLVEKMLEFLYTGDYTVQDNMTEVQILPSDSDKIPESDTWHSEEALRLSQKDQDDMENLSAGEGAVGETAMSLSNQPTASLMNQCSVNKKTSVAGEGPLTGSSEQMDAIDESLTDCHPCYFHLRMYGEADYFMIEDLKIKAEENFRDSFENCSEKQILAQAIKELYSTNADYRDIRKLANKLIVKNLRELQGGLTPGIDYDLLKAYPAFAAELCIATMEKYLSVSSSLRQALPLSTVEYKPFEFKKFEYQWGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>W6QPV0</accession>
    <name>W6QPV0_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Nicotinate phosphoribosyltransferase</fullName>
            <ecNumber evidence="3 9">6.3.4.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">NPT1</name>
        <name evidence="12" type="ORF">PROQFM164_S04g000995</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>5-phospho-alpha-D-ribose 1-diphosphate + nicotinate + ATP + H2O = nicotinate beta-D-ribonucleotide + ADP + phosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:36163"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32544"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from nicotinate: step 1/1.</text>
    </comment>
    <comment type="PTM">
        <text evidence="9">Transiently phosphorylated on a His residue during the reaction cycle. Phosphorylation strongly increases the affinity for substrates and increases the rate of nicotinate D-ribonucleotide production. Dephosphorylation regenerates the low-affinity form of the enzyme, leading to product release.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the NAPRTase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.21" evidence="3 9"/>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM36114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QPV0"/>
    <dbReference type="STRING" id="1365484.W6QPV0"/>
    <dbReference type="OMA" id="IEHCLEY"/>
    <dbReference type="OrthoDB" id="193380at2759"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00457"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004516">
        <property type="term" value="F:nicotinate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034355">
        <property type="term" value="P:NAD+ biosynthetic process via the salvage pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01401">
        <property type="entry name" value="PncB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.140.10:FF:000009">
        <property type="entry name" value="Nicotinate phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.140.10">
        <property type="entry name" value="nicotinate phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041525">
        <property type="entry name" value="N/Namide_PRibTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040727">
        <property type="entry name" value="NAPRTase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006406">
        <property type="entry name" value="Nic_PRibTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007229">
        <property type="entry name" value="Nic_PRibTrfase-Fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036068">
        <property type="entry name" value="Nicotinate_pribotase-like_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01514">
        <property type="entry name" value="NAPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11098">
        <property type="entry name" value="NICOTINATE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11098:SF1">
        <property type="entry name" value="NICOTINATE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04095">
        <property type="entry name" value="NAPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17767">
        <property type="entry name" value="NAPRTase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000484">
        <property type="entry name" value="NAPRT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51690">
        <property type="entry name" value="Nicotinate/Quinolinate PRTase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54675">
        <property type="entry name" value="Nicotinate/Quinolinate PRTase N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6 9" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nicotinate phosphoribosyltransferase N-terminal" evidence="11">
        <location>
            <begin position="15"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="Nicotinate/nicotinamide phosphoribosyltransferase" evidence="10">
        <location>
            <begin position="180"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CDM36114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="452" mass="51218" checksum="AAE6403641553DA1" modified="2014-04-16" version="1">MGQDMSPPQGVTSLLDTDLYKLTMQCAVLKYFPDVYVAYGYTNRTPQMKLHRGAYKWLLEQMDKLAVIRVTAEEREWLRQKCPYLNDEYLAFLETFHLRPSEHIKIKFIPEEDTGSDDDAGDVEYMVEGLWLDTILYEIPLLALTSQAYFMFTDKDWDYENQEDKAYRKGCTLLRNGCVFSEFGSRRRRDYHTQDLVMKGLCRAAEEGKKQGWPGVLAGTSNVHFAMKYNTSAVGTVAHEWYMTIAAITDDYQNANELALSYWLGCFGEGVLGIALTDTFGTPAFLRAFSKPISVPNQKGGTNPSTTTYAQSYTGVRQDSGDPAFFIKMVRDFYDSQGITETKTVVFSDSLDIEHCLEYKTIAEEAGFKPTFGVGTFFTNDFINRSTGLKSKPLNIVIKIASANGSPAVKLSDNLGKNMGDSEKVQEVKKKLGYIEHEWEEGDESRRWTKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W6QQ04</accession>
    <name>W6QQ04_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Hly-III-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PROQFM164_S14g000024</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ADIPOR family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792028">
        <property type="protein sequence ID" value="CDM38525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QQ04"/>
    <dbReference type="STRING" id="1365484.W6QQ04"/>
    <dbReference type="OMA" id="LWRCLHM"/>
    <dbReference type="OrthoDB" id="529367at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004254">
        <property type="entry name" value="AdipoR/HlyIII-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855:SF52">
        <property type="entry name" value="ADIPONECTIN RECEPTOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855">
        <property type="entry name" value="ADIPOR/PROGESTIN RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03006">
        <property type="entry name" value="HlyIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="74"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="109"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR604254-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM38525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="210" mass="23654" checksum="44BD1D179ABE0706" modified="2014-04-16" version="1">MPTYSYKRLLRLWRCLHIETMNIWTHLLGSMAFIAVGFELNHTVPRSQDLNFDRGDLGAGFHTLRSHSYNIHHLWGRLDILGICFLALEAGTSMTYYAFYCRPFIQREYWGLNLFSAIGAAFALFDTGGGGNKMRTLRGGVFSQLAISAMLPILQSVIDLGWTRASNEIGAGWYLAEALSLLTGVSVFVCRFPERLSPGTFDIWGHSHQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W6QQ34</accession>
    <name>W6QQ34_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-chaperonin molecular chaperone ATPase</fullName>
            <ecNumber evidence="2">3.6.4.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">SSB1</name>
        <name evidence="10" type="ORF">PROQFM164_S05g000012</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.10" evidence="2"/>
    <dbReference type="EMBL" id="HG792019">
        <property type="protein sequence ID" value="CDM36179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QQ34"/>
    <dbReference type="STRING" id="1365484.W6QQ34"/>
    <dbReference type="OMA" id="NIPPMQA"/>
    <dbReference type="OrthoDB" id="2401965at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000172">
        <property type="entry name" value="Heat shock 70 kDa protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.10:FF:000014">
        <property type="entry name" value="Heat shock protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000026">
        <property type="entry name" value="Heat shock protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000004">
        <property type="entry name" value="Heat shock protein SSB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000005">
        <property type="entry name" value="Heat shock protein ssb1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001413">
        <property type="entry name" value="PRK00290.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0346">Stress response</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CDM36179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="615" mass="66865" checksum="06407B09C7324DA1" modified="2014-04-16" version="1">MADSEVYDGAVGIDLGTTYSCVANYEGTNVEIIANDQGSYTTPSFVSFTDKERLIGDAAKNQAAMNPANTVFDIKRLIGRRFDDPIVKKDVESWPFKVIDQGGNPVVQVEYLNETKTFSPQEISSMVLMKMKEVAEIKLGKKVEKAVITVPAYFNDNQRQATKDAGAIAGLNVLRIINEPTAAAIAYGLGAGKSEKERNVLIYDLGGGTFDVSLLNIQGGVFTVKATAGDTHLGGQDFDTNLLDHFKKEFQRKTGKDLSGDARALRRLRTACERAKRTLSNATQTTVEIDSLFDGEDLNSSITRARFEDLNAKAFSGTLEPVQQVLKDSGMPKNKVDEIVLVGGSTRIPRIQKLLSDFFDGKKLEKSINPDEAVAYGAAVQAGILSGKATSAETADLLLLDVVPLSLGVAMEGNIFAPVVNRGQTVPTIKKRTFTTVVDNQSTVQFPVYQGERTNCADNTSLGEFTLAPLPPMRAGEAALECVFEVDVNGILKVTATEKTSGRTANITISNAVGKLSSSEIDQMVDDAAKFKTSDEAFTKRFESRQQLESYISRVEEIVSDPGMSMKLKRGNKERIESALSDAMAQLEVEDSTPEDLKKKELALKRLITKAMATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W6QQB7</accession>
    <name>W6QQB7_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase</fullName>
            <ecNumber evidence="4">2.4.1.256</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Asparagine-linked glycosylation protein 10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">alg10</name>
        <name evidence="17" type="ORF">PROQFM164_S02g001873</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. In the lumen of the endoplasmic reticulum, adds the third and last glucose residue from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide intermediate Glc(2)Man(9)GlcNAc(2)-PP-Dol to produce Glc(3)Man(9)GlcNAc(2)-PP-Dol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>an alpha-D-Glc-(1-&gt;3)-alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl beta-D-glucosyl phosphate = a alpha-D-Glc-(1-&gt;2)-alpha-D-Glc-(1-&gt;3)-alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29543"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19502"/>
            <dbReference type="Rhea" id="RHEA-COMP:19512"/>
            <dbReference type="Rhea" id="RHEA-COMP:19522"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57525"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:132522"/>
            <dbReference type="ChEBI" id="CHEBI:132523"/>
            <dbReference type="EC" id="2.4.1.256"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:29544"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ALG10 glucosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.256" evidence="4"/>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM31722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QQB7"/>
    <dbReference type="STRING" id="1365484.W6QQB7"/>
    <dbReference type="OMA" id="VWDSKIT"/>
    <dbReference type="OrthoDB" id="4769at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106073">
        <property type="term" value="F:dolichyl pyrophosphate Glc2Man9GlcNAc2 alpha-1,2-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016900">
        <property type="entry name" value="Alg10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12989">
        <property type="entry name" value="ALPHA-1,2-GLUCOSYLTRANSFERASE ALG10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12989:SF10">
        <property type="entry name" value="DOL-P-GLC:GLC(2)MAN(9)GLCNAC(2)-PP-DOL ALPHA-1,2-GLUCOSYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04922">
        <property type="entry name" value="DIE2_ALG10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="45"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="100"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="168"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="232"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="316"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="362"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="405"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="449"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="589"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="660"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="484"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="15">
        <location>
            <begin position="489"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="529"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="542"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CDM31722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="693" mass="78769" checksum="2FCE522B40F570E5" modified="2014-04-16" version="1">MSSTSSDWDPVAEELQIVWQLYLLAASDYLHSMANPLESDLSRSARWFVPFGLVLILLWVILVNKTVPEAYLDEVFHVPQAQAYWSHKWMQWDPKLTTPPGLYLFSYALFAIVLLLRGEPTELTPQVLRSTNVGATTVIFPWRLQKLLDTLQRTTNTRPLGANVSHTVLNICLFPPLFFFSGLYYTDVLALVVVVEAYNWDLKRDFERNQESESGNDATKATRSGIQETLGFLAFALAALVFRQTNIFWVSVFLGGLQVVRKIRKSTTPCMSSDVSTIVKQGLQNEVYDPLVSEASFEDYLKTAVSLATVSLKQPFSLLVSVIPHIIVLAAFGAFVVWNNGVVLGHKEFHAAGIHLAQMLYIWPYFIFFSWPLFVIPLINILALKPLPKYLNLGLPPKQRKYPKLKAALIVIPFMLAVVHFNTIVHPFTLADNRHYVFYVFRILMLHPAIKYAAVPVYFLCGWVVISAFGFTTIQRPPKTLRVHKAAPDAPPAPTPAPDPAPAPVAQEPKSTQSSARKPLLAHQQPPKGTKKPNRSNYKKIKKDDPETKKTDLTELPAEITDPNDPAVLARVQQHIFTRQRELLEAPRVSFVLVWLAATSLSLITAPLVEPRYLIIPWVMWRVHLPPTPCLFRDRDIRPRTEEAKRRSDLIVNGPKFVETVWFLIINLITGYLFLYKGFEWPQEPGKIQRFMW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>W6QQT0</accession>
    <name>W6QQT0_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type DNA-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PROQFM164_S11g000014</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792025">
        <property type="protein sequence ID" value="CDM38311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QQT0"/>
    <dbReference type="STRING" id="1365484.W6QQT0"/>
    <dbReference type="OMA" id="WYLFIND"/>
    <dbReference type="OrthoDB" id="39175at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052073">
        <property type="entry name" value="Amide_Lactam_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47171">
        <property type="entry name" value="FARA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47171:SF5">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="42"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CDM38311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="594" mass="66905" checksum="9082D7104B34401A" modified="2014-04-16" version="1">MTSYSAVGGDCRVLGKHPTMQIHPFADALSKSLNMQPRANAVCTRCHSSKIRCDLEGRRSGKCSRCERIGYTCQPHIGKRRRALHASLYSSHTSIPSPSRAVPVTQESTAQEAPSPFRHLGRRDITCVGPGDVNGSQQPNSIDGSQLILDISQACRLPSPIIAQALTDFYFRELFYFVPVLDRGQSEIETSTLLQQCLCFAGSTMRQTAGPAEWTTFAIYGRIRTLLFLNHDPAPLNMLSALCILSTWFPYSPDAIVLDNPWQWAGMAIRLAIQLHLHENETYSRLEDPGRARRMWWYLFINDTLQTACCGRPGMFPLETSVPLPFPSDFKHVDLGSRVFCQLTVLCTKLRKVVDLARVDKASSEQVYLNLDGLRVWREQLPLESQLFDVETRQPYNRAVAELHIFYLVTVILTCFLGRRDNPSLFKYASMAASSCISRLYEEILYHEDVQYLLAMHTWANLVAGIPRAFGDSDVLNPDRDEELRISKQVLEIMREKHTSATFVLNKINGLNNMRADSVPAQADNTCGALPVSGQIQLAQLFPFPSRFCPMLRILRTAEASENQPPDALLTLPEDSNDWPMDWSSFLFDGPMSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W6QQT8</accession>
    <name>W6QQT8_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oxoglutarate/iron-dependent dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S11g000024</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="HG792025">
        <property type="protein sequence ID" value="CDM38321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QQT8"/>
    <dbReference type="STRING" id="1365484.W6QQT8"/>
    <dbReference type="OMA" id="TFEYYEI"/>
    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isopenicillin N synthase-like Fe(2+) 2OG dioxygenase" evidence="2">
        <location>
            <begin position="180"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM38321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="281" mass="31632" checksum="803D4F0C8785A32B" modified="2014-04-16" version="1">MTTIHQVPNEAGANLNMAHLVTVDLARIVTGDSQERQKLYDAATRPGAFFLDFKQSSEAILDASQQLYALSDRYFQRPLTEKLKDFREDQPASSDRGYKSSDCDETFEFADDELFRGDLRLPSILQDESDRVRQFNKLCHAAAMSILSSLSDSLGLEGDGRFEAYHQTTDSSDTGLKLIYEPSIDKATDVVENKHTDSGSLTLLFYEQLGLHVYLPEQDRWDFAAVPKPGCALVTVADSLRRLSDLKFHSPLHRVTQPRDGAVKRYFLSYFLRPSHTAKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W6QR01</accession>
    <name>W6QR01_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PROQFM164_S11g000094</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792025">
        <property type="protein sequence ID" value="CDM38391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QR01"/>
    <dbReference type="STRING" id="1365484.W6QR01"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CDM38391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="69" mass="7385" checksum="8C69C950547B6C98" modified="2014-04-16" version="1">MSDQGADLSAGSSSPVTPSLQLKEPEKEILQRQIHTPKCHMSRLGLLYTCATTYELLVLAISSIAAIIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W6QR69</accession>
    <name>W6QR69_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PROQFM164_S12g000075</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792026">
        <property type="protein sequence ID" value="CDM38466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QR69"/>
    <dbReference type="OrthoDB" id="4361003at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CDM38466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="250" mass="28572" checksum="F47A8F92B523BE7C" modified="2014-04-16" version="1">MLSCPPFSPTNNLPVQHYHYQSQPIIDHKRSQVSARSGSPDTEDHNRRTQQASNKSDTGFYQVFSQFIDENRGHTSQVLQPCINQSTRSVATEVATSVTSPRDYILPRSATKAEIHKLPPLNTKKRAAAASSLPQKRHRHSHSPPQIPDSSRLVYRKRLPSLTKVSRQMVNDTIQYLQTLSDHILISDTILPREWATIHLATQLLQSRYQEIIAKEEIETDTVSDFDFPPTQPEEKCRKCTATEEERLYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W6QT55</accession>
    <name>W6QT55_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S02g002858</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QT55"/>
    <dbReference type="OMA" id="AIEFFIC"/>
    <dbReference type="OrthoDB" id="5324651at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM32707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="118" mass="13530" checksum="B538C303C449C47A" modified="2014-04-16" version="1">MQTIMFSKPAALENWVWLFIDAPNSRHGLSPQGLAGSLDDAALAAKPLIPYKNWQRLVSGIRHAAVHRLSQDHESLLRMNRVAIEFFICIGGLSRVDKLRRLLEFLENRLPKSERRRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W6QTL5</accession>
    <name>W6QTL5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Nucleotide-binding, alpha-beta plait</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PROQFM164_S02g003033</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792016">
        <property type="protein sequence ID" value="CDM32882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QTL5"/>
    <dbReference type="STRING" id="1365484.W6QTL5"/>
    <dbReference type="OMA" id="LPWNTTA"/>
    <dbReference type="OrthoDB" id="439808at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd21608">
        <property type="entry name" value="RRM2_NsCP33_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000634">
        <property type="entry name" value="Related to glycine-rich RNA-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048289">
        <property type="entry name" value="RRM2_NsCP33-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052462">
        <property type="entry name" value="SLIRP/GR-RBP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48027">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN 87F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="2"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CDM32882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="102" mass="10569" checksum="8F96C53357E9BBE4" modified="2014-04-16" version="1">MSKIYVGNLSWHTSDESLRAAFGEYGNIVDSIVMVDRETGRSRGFGFVTFSSAEEAEAAINALNEQDLDGRRIRVNLANARPSGGGGFGGGGGAGGAGGGRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W6QUX1</accession>
    <name>W6QUX1_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">O-acyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PROQFM164_S03g000066</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Sterol O-acyltransferase that catalyzes the formation of stery esters.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Endoplasmic reticulum membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QUX1"/>
    <dbReference type="STRING" id="1365484.W6QUX1"/>
    <dbReference type="OMA" id="FICQMLQ"/>
    <dbReference type="OrthoDB" id="10039049at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034737">
        <property type="term" value="F:ergosterol O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008204">
        <property type="term" value="P:ergosterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004299">
        <property type="entry name" value="MBOAT_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014371">
        <property type="entry name" value="Oat_ACAT_DAG_ARE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10408">
        <property type="entry name" value="STEROL O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10408:SF9">
        <property type="entry name" value="STEROL O-ACYLTRANSFERASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03062">
        <property type="entry name" value="MBOAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000439">
        <property type="entry name" value="Oat_ACAT_DAG_ARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10 14" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="97"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="175"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="199"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="329"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="382"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="481"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="510"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR000439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000439-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDM33342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="533" mass="61308" checksum="A2FC2A6C84A4C349" modified="2014-04-16" version="1">MSSAVSQDESAALRPRAVPIQPNGKSDVAHPLPVDKLIQDISGHSTPISEDAPPSAHSISSARKQVRARNRLFYTIDYVPRVSHFDPDSDYHNFRGFFTLFWIGLAIMVGTSILRNIKDTGFPLQVRVWSLLTANVWGMGLSDAAMVISSGLVLPMHQLWRSGPQWLRWSRGGMLLQSLCEALWLVLWINWPFMMKWTWTAQVFFTLHTLTILMKLHSYAFYNGHLSETERRLASLDKPGLKSPEPPAAIHYPEVHRRRPSMKKPNEDQSAEPLERLREDLATELTSPLGNISYPQNLHVGNYVDFLFCPTLCYELEYPRRKERRWSEIGWKAAAVFGCIFLLTLTSEEFIVPVLSVASAQLRAVSSVTDKALILAETISMLLFPFMIIFLLVFLVIFEYVLGAFAELTRFADRHFYADWWNSCDWMEFSREWNVPVHHFLFRHVYWPARSNFSQPVAMFITFLVSSVFHELVMSCITKKLRGYGFLAMMLQLPIVAIQKSRFFRGRTILNNAVFWFSMILGLSMMCAFYVLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W6QVF5</accession>
    <name>W6QVF5_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Amino acid/polyamine transporter I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PROQFM164_S09g000025</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792023">
        <property type="protein sequence ID" value="CDM38109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QVF5"/>
    <dbReference type="STRING" id="1365484.W6QVF5"/>
    <dbReference type="OMA" id="FISWTCC"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000006">
        <property type="entry name" value="General amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF38">
        <property type="entry name" value="PROLINE TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="74"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="124"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="153"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="183"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="236"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="278"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="331"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="376"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="401"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="448"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="476"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="8">
        <location>
            <begin position="43"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM38109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="538" mass="59386" checksum="BEC7B67DE6C2D5D3" modified="2014-04-16" version="1">MATIEGDQHPISEKGKSLRTLVEADLLDDRYVTTTKRGLKNRHVQLMALGGTIGTGLFVGSGQALAIGGPASLLLGYLFISAMVYGLVTAIAEVGAYLPVHGGTMSYHGFRYVSRSMGFAMGYLYWYSLGILVPYEITAAGLVIGYWDQNGSINIAVWITVMMVVIVALNFMPVRVYGESEFWFAGVKIITLIGLLMVSFILFWGGGPSRQRLGFHYWNNPRPFNAYLATGDSGRFVALLKCTVSSAIAFIFAPELIVISGGEMESPRRNIPRAARRYIYRLIFFYIFGVLAIGVICPSDASRLTKSDGTVSSSPFVIGIQNAGIPVLDHIVNAAVLTSAWSAGNSFLYMSSRSLYSLAMSGNAPHVFKTCNRWGVPYWAVSVSACFSALAYLAVGNSSSIVFNWFVNFTNTSGFISWICCSVVFLRFRKAVKAQGIEQPYKSKMQPYGVYFGLAGATLMALINGFTVFFPSEWSVSNFFTAYIGIPAFLILYFGHRALYWSDPWAWHPEEVDMHTGLDEIIAAEQPPKPRGPWWKFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W6QWC3</accession>
    <name>W6QWC3_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Flavoprotein transmembrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PROQFM164_S03g000526</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM33802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QWC3"/>
    <dbReference type="STRING" id="1365484.W6QWC3"/>
    <dbReference type="OMA" id="WPYHFIS"/>
    <dbReference type="OrthoDB" id="10006946at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000293">
        <property type="term" value="F:ferric-chelate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051410">
        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361:SF9">
        <property type="entry name" value="FERRIC REDUCTASE TRANSMEMBRANE COMPONENT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="26"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="Ferric oxidoreductase" evidence="8">
        <location>
            <begin position="93"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CDM33802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="264" mass="29822" checksum="DDEFF82AD77B48F8" modified="2014-04-16" version="1">MSWPYHFISLSENDKLHRRELLDLRGYYAQWSIIVVIVAVRIFRFATRSTAKWDGPVSGKTRQYLVCGLWLLWLLGLSIWNSGDDYLHLTKALGRVGLSQLPLQVLMSPAYISRPAASSVLSLLTGIPQPTLTPYHRLFGRAVVSLLLAHAALYTLFFVQSSHPDFGILLLKRIQDLDVQCGLAAIFSAVLLILFVRPASQKGLQSWLVQGSFQERRKMFYFGHVSLVVLLCVAAYIHVKQAQKYILQTLAASMLNWVCSWALC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W6QWW3</accession>
    <name>W6QWW3_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Genomic scaffold, ProqFM164S03</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PROQFM164_S03g000741</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">FM164</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QWW3"/>
    <dbReference type="STRING" id="1365484.W6QWW3"/>
    <dbReference type="OMA" id="SYMAFPN"/>
    <dbReference type="OrthoDB" id="340500at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071034">
        <property type="term" value="P:CUT catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Putative exosome complex exonuclease Rrp40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026699">
        <property type="entry name" value="Exosome_RNA_bind1/RRP40/RRP4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041054">
        <property type="entry name" value="Rrp40_N_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21321:SF1">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21321">
        <property type="entry name" value="PNAS-3 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15985">
        <property type="entry name" value="KH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18311">
        <property type="entry name" value="Rrp40_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21262">
        <property type="entry name" value="RRP40_S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0271">Exosome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Exosome complex exonuclease Rrp40 N-terminal" evidence="5">
        <location>
            <begin position="25"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="165"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF15985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF18311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CDM34017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="271" mass="28799" checksum="B7D3D12DBADDCB55" modified="2014-04-16" version="1">MTALVLLPSDEVPQDHLPTNNSNPLRLGPGLRILSQPSSNGSNHVLTATQAGLLTTDAKRNTVSLLSFPNRRYIPTVNDFVIAQIHHSSVDFFHCMVTPHTAHALLGQLSFEGASKKTRPMLKQGELVYARVQSVGLGAGAEVELTCVNPATGKADGGLGPLTGGMVFDVSTGMAARLIRASSTSAENTDAIEGLAVLSELGKKLESLGGFEIAVGRNGKVWVDCSIAAESAVKVTVAIGRCLQETDQQNLHTHDQKKLVMKILRDMKLVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W6QXV8</accession>
    <name>W6QXV8_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">arginine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Arginyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PROQFM164_S03g001091</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>tRNA(Arg) + L-arginine + ATP = L-arginyl-tRNA(Arg) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:20301"/>
            <dbReference type="Rhea" id="RHEA-COMP:9658"/>
            <dbReference type="Rhea" id="RHEA-COMP:9673"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78513"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.19"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.19" evidence="2"/>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QXV8"/>
    <dbReference type="STRING" id="1365484.W6QXV8"/>
    <dbReference type="OMA" id="YEFKWER"/>
    <dbReference type="OrthoDB" id="68056at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004814">
        <property type="term" value="F:arginine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006420">
        <property type="term" value="P:arginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07956">
        <property type="entry name" value="Anticodon_Ia_Arg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00671">
        <property type="entry name" value="ArgRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.730.10:FF:000006">
        <property type="entry name" value="Arginyl-tRNA synthetase 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.70">
        <property type="entry name" value="Arginyl tRNA synthetase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001278">
        <property type="entry name" value="Arg-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005148">
        <property type="entry name" value="Arg-tRNA-synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036695">
        <property type="entry name" value="Arg-tRNA-synth_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035684">
        <property type="entry name" value="ArgRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008909">
        <property type="entry name" value="DALR_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00456">
        <property type="entry name" value="argS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11956:SF11">
        <property type="entry name" value="ARGININE--TRNA LIGASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11956">
        <property type="entry name" value="ARGINYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03485">
        <property type="entry name" value="Arg_tRNA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05746">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00750">
        <property type="entry name" value="tRNA-synt_1d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01038">
        <property type="entry name" value="TRNASYNTHARG"/>
    </dbReference>
    <dbReference type="SMART" id="SM01016">
        <property type="entry name" value="Arg_tRNA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00836">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55190">
        <property type="entry name" value="Arginyl-tRNA synthetase (ArgRS), N-terminal 'additional' domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 14" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arginyl tRNA synthetase N-terminal" evidence="13">
        <location>
            <begin position="35"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="DALR anticodon binding" evidence="12">
        <location>
            <begin position="528"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="249"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CDM34367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="645" mass="72296" checksum="F418B711A99CD966" modified="2014-04-16" version="1">MSAASLPASVEALSLQSTAQKSQFAGCFPTLNPMDIYRQHIAEELGKAAGIDSQKIYPRIAWTSTLDKGDLSLPVASLQIKQNPVELARDLVAKFPASDLIHPPTQLGPHIQFFCKRQPLTNNVLGRILKEKAAYGTNGNQGLKDPSDPSKGQKKIIIEFSSPNIAKPFHAGHLRSTIIGGFLANIYTVMGWNVIKMNYLGDWGKQYGLLANGFKQFGDEEALIKDPINHLFDVYVKINRQVSDQEGPIKELKEQIKAKKEKSEDVAELEAQLAKLVDVSEDEKARRYFKSMEDGDPEALALWRKFRDLSIEKYKQTYARLNIDFDVYSGESQIKSESMTDAYKVMEEAGVSEKSEGAVIVDFTKHGAKKLGKAIIVRKDGTPLYLTRDIGAITERDNEYHFDKMIYVVAAQQDLHLAQLFKVTELMGHKDLASRCQHINFGMVRGMSTRKGTVKFLDDILRDVGDKMHEVMKKNEVKYAQVEDPVKTADILGITSVMVQDMTGKRVNGYEFNLDAMTSFEGDTGPYLQYAHARLCSMTRKSELDVNELVNANFDLLTEQHAVDLIRLLAQWPDVLLQTAKTLEPITVLSYLFKMTHMLSSSYDVLKVIGSEPDVKQARMALYASARQVLNNGMRVLGLSPVQRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>W6QYT9</accession>
    <name>W6QYT9_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Histidine biosynthesis trifunctional protein</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="19">Phosphoribosyl-AMP cyclohydrolase</fullName>
                <ecNumber evidence="19">3.5.4.19</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="19">Phosphoribosyl-ATP pyrophosphohydrolase</fullName>
                <ecNumber evidence="19">3.6.1.31</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="19">Histidinol dehydrogenase</fullName>
                <shortName evidence="19">HDH</shortName>
                <ecNumber evidence="19">1.1.1.23</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="22" type="primary">his-3</name>
        <name evidence="22" type="ORF">PROQFM164_S03g001437</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">FM164</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 19">
            <text>1-(5-phospho-beta-D-ribosyl)-5'-AMP + H2O = 1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide</text>
            <dbReference type="Rhea" id="RHEA:20049"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58435"/>
            <dbReference type="ChEBI" id="CHEBI:59457"/>
            <dbReference type="EC" id="3.5.4.19"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 19">
            <text>1-(5-phospho-beta-D-ribosyl)-ATP + H2O = 1-(5-phospho-beta-D-ribosyl)-5'-AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22828"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:59457"/>
            <dbReference type="ChEBI" id="CHEBI:73183"/>
            <dbReference type="EC" id="3.6.1.31"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18 19">
            <text>L-histidinol + 2 NAD(+) + H2O = L-histidine + 2 NADH + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:20641"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
            <dbReference type="ChEBI" id="CHEBI:57699"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="6">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/9.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 3/9.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 9/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7 19">In the C-terminal section; belongs to the histidinol dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.19" evidence="19"/>
    <dbReference type="EC" id="3.6.1.31" evidence="19"/>
    <dbReference type="EC" id="1.1.1.23" evidence="19"/>
    <dbReference type="EMBL" id="HG792017">
        <property type="protein sequence ID" value="CDM34712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6QYT9"/>
    <dbReference type="STRING" id="1365484.W6QYT9"/>
    <dbReference type="OMA" id="SVFIGAW"/>
    <dbReference type="OrthoDB" id="1703565at2759"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00007"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004399">
        <property type="term" value="F:histidinol dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004635">
        <property type="term" value="F:phosphoribosyl-AMP cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004636">
        <property type="term" value="F:phosphoribosyl-ATP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:L-histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06572">
        <property type="entry name" value="Histidinol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11546">
        <property type="entry name" value="NTP-PPase_His4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.1080:FF:000002">
        <property type="entry name" value="Histidine biosynthesis bifunctional protein HisIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.1300:FF:000001">
        <property type="entry name" value="Histidine biosynthesis trifunctional protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.810:FF:000002">
        <property type="entry name" value="Histidine biosynthesis trifunctional protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1980:FF:000050">
        <property type="entry name" value="Histidine biosynthesis trifunctional protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1980:FF:000001">
        <property type="entry name" value="Histidinol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1080">
        <property type="entry name" value="MazG-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1980">
        <property type="entry name" value="Nitrogenase molybdenum iron protein domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.810">
        <property type="entry name" value="Phosphoribosyl-AMP cyclohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01024">
        <property type="entry name" value="HisD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008179">
        <property type="entry name" value="HisE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016298">
        <property type="entry name" value="Histidine_synth_trifunct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001692">
        <property type="entry name" value="Histidinol_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012131">
        <property type="entry name" value="Hstdl_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021130">
        <property type="entry name" value="PRib-ATP_PPHydrolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002496">
        <property type="entry name" value="PRib_AMP_CycHydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038019">
        <property type="entry name" value="PRib_AMP_CycHydrolase_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00069">
        <property type="entry name" value="hisD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03188">
        <property type="entry name" value="histidine_hisI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21256:SF2">
        <property type="entry name" value="HISTIDINE BIOSYNTHESIS TRIFUNCTIONAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21256">
        <property type="entry name" value="HISTIDINOL DEHYDROGENASE HDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00815">
        <property type="entry name" value="Histidinol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01502">
        <property type="entry name" value="PRA-CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01503">
        <property type="entry name" value="PRA-PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001257">
        <property type="entry name" value="His_trifunctional"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00083">
        <property type="entry name" value="HOLDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101386">
        <property type="entry name" value="all-alpha NTP pyrophosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141734">
        <property type="entry name" value="HisI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00611">
        <property type="entry name" value="HISOL_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 19" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="13 19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="16 19" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="11 19" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="15 19" id="KW-0520">NAD</keyword>
    <keyword evidence="10 19" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14 19" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Phosphoribosyl-AMP cyclohydrolase" evidence="21">
        <location>
            <begin position="225"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="393"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="20">
        <location>
            <begin position="410"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00005204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00008260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00049489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRNR" id="PIRNR001257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF01502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="CDM34712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="871" mass="92526" checksum="3DBF7F5E09A12210" modified="2014-04-16" version="1">MATPFLISHDPSSPTSGSGLSLKQIAYFGRVLIKVATLAEAEQFLRQNFRALDIFVDATEISSTGDLVDILNAGAAKILINLDQLTTLSEEQSVPSSRLLVNALSDSQLDTFQQSIAVNAERSEASVCTTPSTVLAAAEKLKISSDSPRLFTIFGSQTVSEDAITNVTKQGAIAIVPSQALTVERDVAGQVSAAKLIASAAVTDQANGLYATSVTDERGACLGFVWSSDESIVEALRTGTGVYQSRKRGLWYKGQSSGDVQELIRIGFDCDADCLVFVVKQIGRGFCHLGTETCFGASSGLSRLQKTLDARKADAPAGSYTARLFNEPKLIDAKIMEEADELCRAETKDEIAFEAADLFYFALTKCTAAGVSLEDIERNLDLKSLKVKRRKGDAKGPWAEKAGLAKPESAPAPAPAPAPAPVEDRTTRIEMKRVITASTTPQVVTDYLKRPSQKSNEAIVNLVKPIIHDVRDGGDAAVLKYTHKFEHATSLTSPVIHAPFPAELMKLSPDVQEAIDISIGNIERFHSAQMGSNETLQMETMPGVVCSRFSRPIERVGLYIPGGTAVLPSTAMMLGVPAQVAGCSKIVLASPPRSDGSISPEIVYVAHKVGAESIVLAGGAQAVAAMAYGTESITKVDKILGPGNQFVTAAKMFVSNDTSAGVSIDMPAGPSEVLVIADKTAVPAFVASDLLSQAEHGIDSQVILIAAGLNEAELRAIEDEVDAQAKALPRMDIVRGSLAHSVTFVVRDIEEAMTLSNDYAPEHLILQVENAESIVKDVQNAGSVFIGHWTPESVGDYSAGVNHSLPTYGYAKQYSGVNLGSFLKHITSSNLTADGLLGLAKTVETLAAVEGLEAHKRAVSIRVAHMKKNQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W6R054</accession>
    <name>W6R054_PENRF</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Genomic scaffold, ProqFM164S04</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PROQFM164_S04g000078</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">FM164</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6R054"/>
    <dbReference type="STRING" id="1365484.W6R054"/>
    <dbReference type="OMA" id="MDYIGNS"/>
    <dbReference type="OrthoDB" id="3645574at2759"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF37">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CDM35197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030686"/>
        </source>
    </evidence>
    <sequence length="303" mass="35282" checksum="03B8A5BDFEE5A282" modified="2014-04-16" version="1">MDYIGNSEVQMLSETWDEDCHEQVKRTNIFRGPSRMMLSLIQIPLPRIENGGIPTNISRSLTYSAADVYYLDILSCYDNRIRYQLNSISNADDGRAQIVRLTIMKALLPHFSNKALREGPFLYRLTDLHPSNIFIDSDWNVKFVIDLEWACSLPAETLRPPYWLTGCSVDELTGGHLETFSEAYEEFVGIFEEEEQQFSPINNDHSYRTNLMRNGWQVGNFWYFHALDSPKGLFNLFSQHIYPLFAPSSQSKDHFARVVSDFWAPDVEKVLAAKLRDKEEYEKTLRQRFEDAVINEKDRDSEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>W6R1T9</accession>
    <name>W6R1T9_PENRF</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 17">Elongator complex protein 3</fullName>
            <ecNumber evidence="17">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">ELP3</name>
        <name evidence="22" type="ORF">PROQFM164_S04g000653</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Penicillium roqueforti (strain FM164)</name>
        <dbReference type="NCBI Taxonomy" id="1365484"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2014" name="Nat. Commun." volume="5" first="2876" last="2876">
            <title>Multiple recent horizontal transfers of a large genomic region in cheese making fungi.</title>
            <authorList>
                <person name="Cheeseman K."/>
                <person name="Ropars J."/>
                <person name="Renault P."/>
                <person name="Dupont J."/>
                <person name="Gouzy J."/>
                <person name="Branca A."/>
                <person name="Abraham A.L."/>
                <person name="Ceppi M."/>
                <person name="Conseiller E."/>
                <person name="Debuchy R."/>
                <person name="Malagnac F."/>
                <person name="Goarin A."/>
                <person name="Silar P."/>
                <person name="Lacoste S."/>
                <person name="Sallet E."/>
                <person name="Bensimon A."/>
                <person name="Giraud T."/>
                <person name="Brygoo Y."/>
            </authorList>
            <dbReference type="PubMed" id="24407037"/>
            <dbReference type="DOI" id="10.1038/ncomms3876"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">FM164</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Catalytic tRNA acetyltransferase subunit of the elongator complex, which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). In the elongator complex, acts as a tRNA uridine(34) acetyltransferase by mediating formation of carboxymethyluridine in the wobble base at position 34 in tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>uridine(34) in tRNA + acetyl-CoA + S-adenosyl-L-methionine + H2O = 5-(carboxymethyl)uridine(34) in tRNA + 5'-deoxyadenosine + L-methionine + CoA + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:61020"/>
            <dbReference type="Rhea" id="RHEA-COMP:10407"/>
            <dbReference type="Rhea" id="RHEA-COMP:11727"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74882"/>
            <dbReference type="EC" id="2.3.1.311"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:61021"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17 18">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="17 18">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 17">Belongs to the ELP3 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="17"/>
    <dbReference type="EMBL" id="HG792018">
        <property type="protein sequence ID" value="CDM35772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W6R1T9"/>
    <dbReference type="STRING" id="1365484.W6R1T9"/>
    <dbReference type="OMA" id="TFETRPD"/>
    <dbReference type="OrthoDB" id="10265243at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000030686">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106261">
        <property type="term" value="F:tRNA uridine(34) acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002926">
        <property type="term" value="P:tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry
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